Protein

## Lalb_10596

Length
439 amino acids

### Protein family membership

- Tubulin (IPR000217)
  - Alpha tubulin (IPR002452)

### Homologous superfamilies

1. Homologous superfamily
   4 - 269
   - Tubulin/FtsZ, GTPase domain superfamily (IPR036525)
   270 - 384
   - Tubulin/FtsZ, C-terminal domain superfamily (IPR037103)
   385 - 438
   - Tubulin, C-terminal (IPR023123)
2. Homologous superfamily
   247 - 438
   - Tubulin/FtsZ, C-terminal (IPR008280)

1 50 100 150 200 250 300 350 400 439

### Domains and repeats

1. Domain
   6 - 247
   - Tubulin/FtsZ, GTPase domain (IPR003008)
   249 - 394
   - Tubulin/FtsZ, 2-layer sandwich domain (IPR018316)

1 50 100 150 200 250 300 350 400 439

### Detailed signature matches

1. IPR036525
   Tubulin/FtsZ, GTPase domain superfamily
   1. G3DSA:3.40.50...
      4 - 269
      GENE3D
      G3DSA:3.40.50.1440 (G3DSA:3.40.50.1440)
   2. SSF52490 (Tubulin n...)
      4 - 245
      SUPERFAMILY
      SSF52490 (Tubulin nucleotide-binding domain-like)
2. IPR008280
   Tubulin/FtsZ, C-terminal
   1. SSF55307 (Tubulin C...)
      247 - 438
      SUPERFAMILY
      SSF55307 (Tubulin C-terminal domain-like)
3. IPR037103
   Tubulin/FtsZ, C-terminal domain superfamily
   1. G3DSA:3.30.13...
      270 - 384
      GENE3D
      G3DSA:3.30.1330.20 (G3DSA:3.30.1330.20)
4. IPR023123
   Tubulin, C-terminal
   1. G3DSA:1.10.28... (H...)
      385 - 438
      GENE3D
      G3DSA:1.10.287.600 (Helix hairpin bin)
5. IPR000217
   Tubulin
   1. PTHR11588 (TUBULIN)
      6 - 438
      PANTHER
      PTHR11588 (TUBULIN)
   2. PR01161 (TUBULIN)
      54 - 73
      PRINTS
      PR01161 (TUBULIN)
      13 - 33
      PRINTS
      PR01161 (TUBULIN)
      109 - 133
      PRINTS
      PR01161 (TUBULIN)
      193 - 213
      PRINTS
      PR01161 (TUBULIN)
      179 - 192
      PRINTS
      PR01161 (TUBULIN)
      96 - 107
      PRINTS
      PR01161 (TUBULIN)
      135 - 153
      PRINTS
      PR01161 (TUBULIN)
      154 - 175
      PRINTS
      PR01161 (TUBULIN)
      381 - 409
      PRINTS
      PR01161 (TUBULIN)
6. IPR002452
   Alpha tubulin
   1. PR01162 (ALPHATUBULIN)
      322 - 343
      PRINTS
      PR01162 (ALPHATUBULIN)
      89 - 102
      PRINTS
      PR01162 (ALPHATUBULIN)
      361 - 380
      PRINTS
      PR01162 (ALPHATUBULIN)
      386 - 402
      PRINTS
      PR01162 (ALPHATUBULIN)
      215 - 227
      PRINTS
      PR01162 (ALPHATUBULIN)
      21 - 36
      PRINTS
      PR01162 (ALPHATUBULIN)
      275 - 290
      PRINTS
      PR01162 (ALPHATUBULIN)
      46 - 59
      PRINTS
      PR01162 (ALPHATUBULIN)
      424 - 439
      PRINTS
      PR01162 (ALPHATUBULIN)
      149 - 161
      PRINTS
      PR01162 (ALPHATUBULIN)
      348 - 361
      PRINTS
      PR01162 (ALPHATUBULIN)
7. IPR003008
   Tubulin/FtsZ, GTPase domain
   1. PF00091 (Tubulin)
      6 - 214
      Pfam
      PF00091 (Tubulin)
   2. SM00864 (Tubulin_4)
      50 - 247
      SMART
      SM00864 (Tubulin_4)
8. IPR018316
   Tubulin/FtsZ, 2-layer sandwich domain
   1. PF03953 (Tubulin_C)
      264 - 392
      Pfam
      PF03953 (Tubulin_C)
   2. SM00865 (Tubulin_C_4)
      249 - 394
      SMART
      SM00865 (Tubulin_C_4)

no IPR
Unintegrated signatures

1. PTHR11588:SF304 (AT...)
   6 - 438
   PANTHER
   PTHR11588:SF304 (AT04270P-RELATED)
2. cd02186 (alpha_tubulin)
   5 - 437
   CDD
   cd02186 (alpha_tubulin)

### Residue annotation

1. beta/alpha domain ...
   5G
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   200D
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   254K
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   255E
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   257Q
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   258T
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   259N
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   261I
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   262P
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   327S
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
   353K
   beta/alpha domain interface
   5G, 200D, 254K, 255E, 257Q, 258T, 259N, 261I, 262P, 327S, 353K
   CDD
   cd02186 (alpha_tubulin)
2. nucleotide binding...
   14Q
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   15A
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   18Q
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   72E
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   102N
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   144G
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   145G
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   146T
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   147G
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   172I
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   207N
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   225Y
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
   229N
   nucleotide binding site
   14Q, 15A, 18Q, 72E, 102N, 144G, 145G, 146T, 147G, 172I, 207N, 225Y, 229N
   CDD
   cd02186 (alpha_tubulin)
3. alpha/beta domain ...
   73P
   alpha/beta domain interface
   73P, 74T, 101A, 102N, 103N, 106I, 182I, 184E, 225Y
   CDD
   cd02186 (alpha_tubulin)
   74T
   alpha/beta domain interface
   73P, 74T, 101A, 102N, 103N, 106I, 182I, 184E, 225Y
   CDD
   cd02186 (alpha_tubulin)
   101A
   alpha/beta domain interface
   73P, 74T, 101A, 102N, 103N, 106I, 182I, 184E, 225Y
   CDD
   cd02186 (alpha_tubulin)
   102N
   alpha/beta domain interface
   73P, 74T, 101A, 102N, 103N, 106I, 182I, 184E, 225Y
   CDD
   cd02186 (alpha_tubulin)
   103N
   alpha/beta domain interface
   73P, 74T, 101A, 102N, 103N, 106I, 182I, 184E, 225Y
   CDD
   cd02186 (alpha_tubulin)
   106I
   alpha/beta domain interface
   73P, 74T, 101A, 102N, 103N, 106I, 182I, 184E, 225Y
   CDD
   cd02186 (alpha_tubulin)
   182I
   alpha/beta domain interface
   73P, 74T, 101A, 102N, 103N, 106I, 182I, 184E, 225Y
   CDD
   cd02186 (alpha_tubulin)
   184E
   alpha/beta domain interface
   73P, 74T, 101A, 102N, 103N, 106I, 182I, 184E, 225Y
   CDD
   cd02186 (alpha_tubulin)
   225Y
   alpha/beta domain interface
   73P, 74T, 101A, 102N, 103N, 106I, 182I, 184E, 225Y
   CDD
   cd02186 (alpha_tubulin)

### GO term prediction

#### Biological Process

GO:0007017 microtubule-based process

#### Molecular Function

GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding

#### Cellular Component

GO:0005874 microtubule

Generated with InterProScan 5.45-80.0