Protein

## Lalb_01655

Length
726 amino acids

### Protein family membership

- Protein arginine N-methyltransferase (IPR025799)
  - Protein arginine N-methyltransferase PRMT5 (IPR007857)

- Glycine cleavage system H-protein/Simiate (IPR033753)
  - Glycine cleavage system H-protein (IPR002930)
    - Glycine cleavage system H-protein, subgroup (IPR017453)

### Homologous superfamilies

1. Homologous superfamily
   308 - 604
   - S-adenosyl-L-methionine-dependent methyltransferase (IPR029063)
2. Homologous superfamily
   604 - 722
   - Single hybrid motif (IPR011053)

1 100 200 300 400 500 600 726

### Domains and repeats

1. Domain
   30 - 273
   - PRMT5, TIM barrel domain (IPR035247)
   283 - 449
   - PRMT5 arginine-N-methyltransferase (IPR035075)
   452 - 609
   - PRMT5, oligomerisation domain (IPR035248)
   619 - 701
   - Biotin/lipoyl attachment (IPR000089)

1 100 200 300 400 500 600 726

### Detailed signature matches

1. IPR029063
   S-adenosyl-L-methionine-dependent methyltransferase
   1. SSF53335 (S-adenosy...)
      308 - 604
      SUPERFAMILY
      SSF53335 (S-adenosyl-L-methionine-dependent methyltransferases)
2. IPR011053
   Single hybrid motif
   1. SSF51230 (Single hy...)
      604 - 722
      SUPERFAMILY
      SSF51230 (Single hybrid motif)
3. IPR025799
   Protein arginine N-methyltransferase
   1. PS51678 (SAM_MT_PRMT)
      293 - 600
      PROSITE profiles
      PS51678 (SAM_MT_PRMT)
4. IPR007857
   Protein arginine N-methyltransferase PRMT5
   1. PTHR10738 (PROTEIN ...)
      1 - 605
      PANTHER
      PTHR10738 (PROTEIN ARGININE N-METHYLTRANSFERASE 5)
5. IPR033753
   Glycine cleavage system H-protein/Simiate
   1. cd06848 (GCS_H)
      606 - 700
      CDD
      cd06848 (GCS_H)
   2. PF01597 (GCV_H)
      605 - 723
      Pfam
      PF01597 (GCV_H)
6. IPR002930
   Glycine cleavage system H-protein
   1. MF_00272 (GcvH)
      603 - 722
      HAMAP
      MF_00272 (GcvH)
7. IPR017453
   Glycine cleavage system H-protein, subgroup
   1. TIGR00527
      606 - 724
      TIGRFAMs
      TIGR00527 (TIGR00527)
8. IPR035247
   PRMT5, TIM barrel domain
   1. PF17285 (PRMT5_TIM)
      30 - 273
      Pfam
      PF17285 (PRMT5_TIM)
9. IPR035075
   PRMT5 arginine-N-methyltransferase
   1. PF05185 (PRMT5)
      283 - 449
      Pfam
      PF05185 (PRMT5)
10. IPR035248
    PRMT5, oligomerisation domain
    1. PF17286 (PRMT5_C)
       452 - 609
       Pfam
       PF17286 (PRMT5_C)
11. IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
       619 - 701
       PROSITE profiles
       PS50968 (BIOTINYL_LIPOYL)
12. IPR003016
    2-oxo acid dehydrogenase, lipoyl-binding site
    1. PS00189 (LIPOYL)
       644 - 673
       PROSITE patterns
       PS00189 (LIPOYL)

no IPR
Unintegrated signatures

1. G3DSA:2.70.16...
   452 - 617
   GENE3D
   G3DSA:2.70.160.11 (G3DSA:2.70.160.11)
2. G3DSA:3.20.20...
   1 - 283
   GENE3D
   G3DSA:3.20.20.150 (G3DSA:3.20.20.150)
3. G3DSA:3.40.50... (V...)
   285 - 451
   GENE3D
   G3DSA:3.40.50.150 (Vaccinia Virus protein VP39)
4. cd02440 (AdoMet_MTases)
   349 - 419
   CDD
   cd02440 (AdoMet_MTases)

### Residue annotation

1. S-adenosylmethioni...
   349V
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   350G
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   351A
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   352G
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   353R
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   354G
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   361L
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   377E
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   378K
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   403C
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   404D
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
   405M
   S-adenosylmethionine binding site
   349V, 350G, 351A, 352G, 353R, 354G, 361L, 377E, 378K, 403C, 404D, 405M
   CDD
   cd02440 (AdoMet_MTases)
2. lipoyl attachment ...
   660K
   lipoyl attachment site
   660K
   CDD
   cd06848 (GCS_H)

### GO term prediction

#### Biological Process

GO:0006479 protein methylation
GO:0018216 peptidyl-arginine methylation
GO:0019464 glycine decarboxylation via glycine cleavage system
GO:0035246 peptidyl-arginine N-methylation

#### Molecular Function

GO:0008168 methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity

#### Cellular Component

GO:0005960 glycine cleavage complex

Generated with InterProScan 5.45-80.0