Protein

## Lalb_08512

Length
1,128 amino acids

### Protein family membership

- Haem peroxidase, animal-type (IPR019791)

### Homologous superfamilies

1. Homologous superfamily
   1 - 73
   - Leucine-rich repeat domain superfamily (IPR032675)
   74 - 163
   - Immunoglobulin-like fold (IPR013783)
   164 - 258
   - Immunoglobulin-like fold (IPR013783)
   259 - 354
   - Immunoglobulin-like fold (IPR013783)
   452 - 1,045
   - Haem peroxidase domain superfamily, animal type (IPR037120)
2. Homologous superfamily
   73 - 165
   - Immunoglobulin-like domain superfamily (IPR036179)
   169 - 257
   - Immunoglobulin-like domain superfamily (IPR036179)
   262 - 350
   - Immunoglobulin-like domain superfamily (IPR036179)
   467 - 1,044
   - Haem peroxidase superfamily (IPR010255)

1 200 400 600 800 1000 1128

### Domains and repeats

1. Domain
   24 - 72
   - Cysteine-rich flanking region, C-terminal (IPR000483)
   74 - 165
   - Immunoglobulin-like domain (IPR007110)
     - Immunoglobulin subtype 2 (IPR003598)
     - Immunoglobulin subtype (IPR003599)
   166 - 256
   - Immunoglobulin-like domain (IPR007110)
     - Immunoglobulin subtype 2 (IPR003598)
     - Immunoglobulin subtype (IPR003599)
   263 - 349
   - Immunoglobulin-like domain (IPR007110)
     - Immunoglobulin subtype 2 (IPR003598)
     - Immunoglobulin subtype (IPR003599)
2. Domain
   74 - 153
   - Immunoglobulin I-set (IPR013098)
   169 - 255
   - Immunoglobulin I-set (IPR013098)
   263 - 348
   - Immunoglobulin I-set (IPR013098)
   594 - 1,033
   - Peroxidasin, peroxidase domain (IPR034824)

1 200 400 600 800 1000 1128

### Detailed signature matches

1. IPR032675
   Leucine-rich repeat domain superfamily
   1. G3DSA:3.80.10.10 (R...)
      1 - 73
      GENE3D
      G3DSA:3.80.10.10 (Ribonuclease Inhibitor)
2. IPR036179
   Immunoglobulin-like domain superfamily
   1. SSF48726 (Immunoglo...)
      169 - 257
      SUPERFAMILY
      SSF48726 (Immunoglobulin)
      73 - 165
      SUPERFAMILY
      SSF48726 (Immunoglobulin)
      262 - 350
      SUPERFAMILY
      SSF48726 (Immunoglobulin)
3. IPR013783
   Immunoglobulin-like fold
   1. G3DSA:2.60.40.10 (I...)
      259 - 354
      GENE3D
      G3DSA:2.60.40.10 (Immunoglobulins)
      74 - 163
      GENE3D
      G3DSA:2.60.40.10 (Immunoglobulins)
      164 - 258
      GENE3D
      G3DSA:2.60.40.10 (Immunoglobulins)
4. IPR037120
   Haem peroxidase domain superfamily, animal type
   1. G3DSA:1.10.64... (M...)
      452 - 1,045
      GENE3D
      G3DSA:1.10.640.10 (Myeloperoxidase)
5. IPR010255
   Haem peroxidase superfamily
   1. SSF48113 (Heme-depe...)
      467 - 1,044
      SUPERFAMILY
      SSF48113 (Heme-dependent peroxidases)
6. IPR019791
   Haem peroxidase, animal-type
   1. PF03098 (An_peroxidase)
      473 - 1,019
      Pfam
      PF03098 (An_peroxidase)
   2. PS50292 (PEROXIDASE_3)
      461 - 1,046
      PROSITE profiles
      PS50292 (PEROXIDASE_3)
   3. PR00457 (ANPEROXIDASE)
      924 - 944
      PRINTS
      PR00457 (ANPEROXIDASE)
      995 - 1,009
      PRINTS
      PR00457 (ANPEROXIDASE)
      549 - 564
      PRINTS
      PR00457 (ANPEROXIDASE)
      701 - 719
      PRINTS
      PR00457 (ANPEROXIDASE)
      719 - 739
      PRINTS
      PR00457 (ANPEROXIDASE)
      744 - 770
      PRINTS
      PR00457 (ANPEROXIDASE)
      797 - 807
      PRINTS
      PR00457 (ANPEROXIDASE)
      497 - 508
      PRINTS
      PR00457 (ANPEROXIDASE)
7. IPR000483
   Cysteine-rich flanking region, C-terminal
   1. SM00082 (lrrct1)
      24 - 72
      SMART
      SM00082 (lrrct1)
8. IPR013098
   Immunoglobulin I-set
   1. PF07679 (I-set)
      263 - 348
      Pfam
      PF07679 (I-set)
      74 - 153
      Pfam
      PF07679 (I-set)
      169 - 255
      Pfam
      PF07679 (I-set)
9. IPR007110
   Immunoglobulin-like domain
   1. PS50835 (IG_LIKE)
      74 - 163
      PROSITE profiles
      PS50835 (IG_LIKE)
      263 - 347
      PROSITE profiles
      PS50835 (IG_LIKE)
      166 - 254
      PROSITE profiles
      PS50835 (IG_LIKE)
10. IPR003599
    Immunoglobulin subtype
    1. SM00409 (IG_3c)
       80 - 165
       SMART
       SM00409 (IG_3c)
       269 - 349
       SMART
       SM00409 (IG_3c)
       174 - 256
       SMART
       SM00409 (IG_3c)
11. IPR003598
    Immunoglobulin subtype 2
    1. SM00408 (igc2_5)
       180 - 245
       SMART
       SM00408 (igc2_5)
       86 - 151
       SMART
       SM00408 (igc2_5)
       275 - 338
       SMART
       SM00408 (igc2_5)
12. IPR034824
    Peroxidasin, peroxidase domain
    1. cd09826 (peroxidasi...)
       594 - 1,033
       CDD
       cd09826 (peroxidasin_like)

no IPR
Unintegrated signatures

1. PTHR11475 (OXIDASE/...)
   37 - 164
   PANTHER
   PTHR11475 (OXIDASE/PEROXIDASE)
   276 - 1,095
   PANTHER
   PTHR11475 (OXIDASE/PEROXIDASE)
   181 - 258
   PANTHER
   PTHR11475 (OXIDASE/PEROXIDASE)
2. PTHR11475:SF58 (PER...)
   37 - 164
   PANTHER
   PTHR11475:SF58 (PEROXIDASIN)
   181 - 258
   PANTHER
   PTHR11475:SF58 (PEROXIDASIN)
   276 - 1,095
   PANTHER
   PTHR11475:SF58 (PEROXIDASIN)
3. SSF52058 (L domain-...)
   2 - 77
   SUPERFAMILY
   SSF52058 (L domain-like)
4. cd00096 (Ig)
   91 - 151
   CDD
   cd00096 (Ig)
   185 - 251
   CDD
   cd00096 (Ig)

### Other features

1. Coil
   1,079 - 1,128
   COILS
   Coil (Coil)

### Residue annotation

1. putative homodimer...
   633L
   putative homodimer interface
   633L, 902E, 905R
   CDD
   cd09826 (peroxidasin_like)
   902E
   putative homodimer interface
   633L, 902E, 905R
   CDD
   cd09826 (peroxidasin_like)
   905R
   putative homodimer interface
   633L, 902E, 905R
   CDD
   cd09826 (peroxidasin_like)
2. Ca binding site cd...
   637T
   Ca binding site
   637T, 641D, 643S
   CDD
   cd09826 (peroxidasin_like)
   641D
   Ca binding site
   637T, 641D, 643S
   CDD
   cd09826 (peroxidasin_like)
   643S
   Ca binding site
   637T, 641D, 643S
   CDD
   cd09826 (peroxidasin_like)
3. heme binding site ...
   707R
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
   710E
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
   797T
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
   800L
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
   801R
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
   804H
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
   807I
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
   832F
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
   884L
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
   891R
   heme binding site
   707R, 710E, 797T, 800L, 801R, 804H, 807I, 832F, 884L, 891R
   CDD
   cd09826 (peroxidasin_like)
4. putative substrate...
   761Y
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   764W
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   765M
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   769F
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   796A
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   800L
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   802F
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   958V
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   962F
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   966L
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   967L
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   970F
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   971K
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)
   974R
   putative substrate binding site
   761Y, 764W, 765M, 769F, 796A, 800L, 802F, 958V, 962F, 966L, 967L, 970F, 971K, 974R
   CDD
   cd09826 (peroxidasin_like)

### GO term prediction

#### Biological Process

GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0004601 peroxidase activity
GO:0020037 heme binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0