Protein

## Lalb_05123

Length
2,018 amino acids

### Protein family membership

- Voltage-gated cation channel calcium and sodium (IPR043203)
  - Voltage gated sodium channel, alpha subunit (IPR001696)

### Homologous superfamilies

1. Homologous superfamily
   134 - 243
   - Voltage-dependent channel domain superfamily (IPR027359)
   761 - 875
   - Voltage-dependent channel domain superfamily (IPR027359)
   1,231 - 1,351
   - Voltage-dependent channel domain superfamily (IPR027359)
   1,575 - 1,696
   - Voltage-dependent channel domain superfamily (IPR027359)

1 200 400 600 800 1000 1200 1400 1600 1800 2018

### Domains and repeats

1. Domain
   140 - 426
   - Ion transport domain (IPR005821)
   495 - 701
   - Voltage-gated Na+ ion channel, cytoplasmic domain (IPR024583)
   771 - 998
   - Ion transport domain (IPR005821)
   1,007 - 1,235
   - Sodium ion transport-associated (IPR010526)
   1,239 - 1,366
   - Ion transport domain (IPR005821)
   1,370 - 1,535
   - Ion transport domain (IPR005821)
   1,586 - 1,835
   - Ion transport domain (IPR005821)
   1,842 - 1,877
   - EF-hand domain (IPR002048)

1 200 400 600 800 1000 1200 1400 1600 1800 2018

### Detailed signature matches

1. IPR027359
   Voltage-dependent channel domain superfamily
   1. G3DSA:1.20.12...
      1,575 - 1,696
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
      761 - 875
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
      1,231 - 1,351
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
      134 - 243
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
2. IPR043203
   Voltage-gated cation channel calcium and sodium
   1. PTHR10037 (VOLTAGE-...)
      1,357 - 1,969
      PANTHER
      PTHR10037 (VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM)
      127 - 220
      PANTHER
      PTHR10037 (VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM)
      212 - 1,357
      PANTHER
      PTHR10037 (VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM)
3. IPR001696
   Voltage gated sodium channel, alpha subunit
   1. PR00170 (NACHANNEL)
      1,842 - 1,855
      PRINTS
      PR00170 (NACHANNEL)
      1,807 - 1,826
      PRINTS
      PR00170 (NACHANNEL)
4. IPR005821
   Ion transport domain
   1. PF00520 (Ion_trans)
      1,586 - 1,835
      Pfam
      PF00520 (Ion_trans)
      140 - 426
      Pfam
      PF00520 (Ion_trans)
      771 - 998
      Pfam
      PF00520 (Ion_trans)
      1,370 - 1,535
      Pfam
      PF00520 (Ion_trans)
      1,239 - 1,366
      Pfam
      PF00520 (Ion_trans)
5. IPR024583
   Voltage-gated Na+ ion channel, cytoplasmic domain
   1. PF11933 (Na_trans_c...)
      495 - 701
      Pfam
      PF11933 (Na_trans_cytopl)
6. IPR010526
   Sodium ion transport-associated
   1. PF06512 (Na_trans_a...)
      1,007 - 1,235
      Pfam
      PF06512 (Na_trans_assoc)
7. IPR002048
   EF-hand domain
   1. PS50222 (EF_HAND_2)
      1,842 - 1,877
      PROSITE profiles
      PS50222 (EF_HAND_2)

no IPR
Unintegrated signatures

1. G3DSA:1.10.23...
   1,830 - 1,945
   GENE3D
   G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
2. G3DSA:1.10.28...
   340 - 416
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
   877 - 1,000
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
   1,698 - 1,829
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
   1,395 - 1,527
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
3. PTHR10037:SF288 (SO...)
   127 - 220
   PANTHER
   PTHR10037:SF288 (SODIUM CHANNEL PROTEIN PARA)
   212 - 1,357
   PANTHER
   PTHR10037:SF288 (SODIUM CHANNEL PROTEIN PARA)
   1,357 - 1,969
   PANTHER
   PTHR10037:SF288 (SODIUM CHANNEL PROTEIN PARA)
4. SSF81324 (Voltage-g...)
   1,240 - 1,364
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   140 - 284
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   354 - 419
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   1,360 - 1,435
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   1,471 - 1,532
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   771 - 996
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   1,585 - 1,830
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
5. cd13433 (Na_channel...)
   1,526 - 1,578
   CDD
   cd13433 (Na_channel_gate)

### Other features

1. Coil
   419 - 444
   COILS
   Coil (Coil)
   24 - 58
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   544 - 565
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   662 - 683
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   1,965 - 1,988
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   1,143 - 1,189
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   37 - 69
   MobiDB Lite
   mobidb-lite (disorder_prediction)
3. mobidb-lite (Negati...)
   1,165 - 1,189
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Negative Polyelectrolyte
4. mobidb-lite (Polyam...)
   667 - 681
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   1,143 - 1,164
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   37 - 51
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   1,968 - 1,985
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte

### Residue annotation

1. putative hydrophob...
   1,541M
   putative hydrophobic latch
   1,541M, 1,542F, 1,543M, 1,544T
   CDD
   cd13433 (Na_channel_gate)
   1,542F
   putative hydrophobic latch
   1,541M, 1,542F, 1,543M, 1,544T
   CDD
   cd13433 (Na_channel_gate)
   1,543M
   putative hydrophobic latch
   1,541M, 1,542F, 1,543M, 1,544T
   CDD
   cd13433 (Na_channel_gate)
   1,544T
   putative hydrophobic latch
   1,541M, 1,542F, 1,543M, 1,544T
   CDD
   cd13433 (Na_channel_gate)
2. phosphorylation si...
   1,559S
   phosphorylation site
   1,559S
   CDD
   cd13433 (Na_channel_gate)

### GO term prediction

#### Biological Process

GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport

#### Molecular Function

GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 cation channel activity
GO:0005509 calcium ion binding

#### Cellular Component

GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane

Generated with InterProScan 5.45-80.0