Protein

## Lalb_11376

Length
943 amino acids

### Protein family membership

- Ankyrin repeat and LEM domain-containing protein 1 (IPR034998)

### Homologous superfamilies

1. Homologous superfamily
   45 - 192
   - Ankyrin repeat-containing domain superfamily (IPR036770)
   683 - 733
   - LEM/LEM-like domain superfamily (IPR011015)

1 100 200 300 400 500 600 700 800 943

### Domains and repeats

1. Domain
   69 - 178
   - Ankyrin repeat-containing domain (IPR020683)
   685 - 729
   - LEM domain (IPR003887)
2. Repeat
   88 - 121
   - Ankyrin repeat (IPR002110)
   125 - 157
   - Ankyrin repeat (IPR002110)
   158 - 187
   - Ankyrin repeat (IPR002110)

1 100 200 300 400 500 600 700 800 943

### Detailed signature matches

1. IPR036770
   Ankyrin repeat-containing domain superfamily
   1. G3DSA:1.25.40.20
      45 - 192
      GENE3D
      G3DSA:1.25.40.20 (G3DSA:1.25.40.20)
   2. SSF48403 (Ankyrin r...)
      68 - 189
      SUPERFAMILY
      SSF48403 (Ankyrin repeat)
2. IPR011015
   LEM/LEM-like domain superfamily
   1. SSF63451 (LEM domain)
      691 - 733
      SUPERFAMILY
      SSF63451 (LEM domain)
   2. G3DSA:1.10.72...
      683 - 731
      GENE3D
      G3DSA:1.10.720.40 (G3DSA:1.10.720.40)
3. IPR034998
   Ankyrin repeat and LEM domain-containing protein 1
   1. PTHR46427 (FAMILY N...)
      689 - 942
      PANTHER
      PTHR46427 (FAMILY NOT NAMED)
      68 - 487
      PANTHER
      PTHR46427 (FAMILY NOT NAMED)
4. IPR020683
   Ankyrin repeat-containing domain
   1. PF12796 (Ank_2)
      107 - 178
      Pfam
      PF12796 (Ank_2)
   2. PS50297 (ANK_REP_RE...)
      69 - 166
      PROSITE profiles
      PS50297 (ANK_REP_REGION)
5. IPR003887
   LEM domain
   1. SM00540 (lem_2)
      685 - 729
      SMART
      SM00540 (lem_2)
   2. PF03020 (LEM)
      692 - 726
      Pfam
      PF03020 (LEM)
   3. PS50954 (LEM)
      685 - 729
      PROSITE profiles
      PS50954 (LEM)
6. IPR002110
   Ankyrin repeat
   1. SM00248 (ANK_2a)
      158 - 187
      SMART
      SM00248 (ANK_2a)
      125 - 154
      SMART
      SM00248 (ANK_2a)
      88 - 121
      SMART
      SM00248 (ANK_2a)
   2. PS50088 (ANK_REPEAT)
      125 - 157
      PROSITE profiles
      PS50088 (ANK_REPEAT)

no IPR
Unintegrated signatures

1. cd10454 (GIY-YIG_CO...)
   785 - 897
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
2. cd12934 (LEM)
   691 - 727
   CDD
   cd12934 (LEM)

### Other features

1. Coil
   250 - 270
   COILS
   Coil (Coil)
   33 - 53
   COILS
   Coil (Coil)

### Residue annotation

1. polypeptide substr...
   706K
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   707P
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   708G
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   709P
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   710I
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   711N
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   713A
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   714T
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   717L
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   718Y
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   720K
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
   721K
   polypeptide substrate binding site
   706K, 707P, 708G, 709P, 710I, 711N, 713A, 714T, 717L, 718Y, 720K, 721K
   CDD
   cd12934 (LEM)
2. GIY-YIG motif/moti...
   786F
   GIY-YIG motif/motif A
   786F, 787N, 788Y, 821Y, 822V, 823G
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   787N
   GIY-YIG motif/motif A
   786F, 787N, 788Y, 821Y, 822V, 823G
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   788Y
   GIY-YIG motif/motif A
   786F, 787N, 788Y, 821Y, 822V, 823G
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   821Y
   GIY-YIG motif/motif A
   786F, 787N, 788Y, 821Y, 822V, 823G
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   822V
   GIY-YIG motif/motif A
   786F, 787N, 788Y, 821Y, 822V, 823G
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   823G
   GIY-YIG motif/motif A
   786F, 787N, 788Y, 821Y, 822V, 823G
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
3. putative active si...
   788Y
   putative active site
   788Y, 821Y, 823G, 824K, 829R, 833H, 883E, 897N
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   821Y
   putative active site
   788Y, 821Y, 823G, 824K, 829R, 833H, 883E, 897N
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   823G
   putative active site
   788Y, 821Y, 823G, 824K, 829R, 833H, 883E, 897N
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   824K
   putative active site
   788Y, 821Y, 823G, 824K, 829R, 833H, 883E, 897N
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   829R
   putative active site
   788Y, 821Y, 823G, 824K, 829R, 833H, 883E, 897N
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   833H
   putative active site
   788Y, 821Y, 823G, 824K, 829R, 833H, 883E, 897N
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   883E
   putative active site
   788Y, 821Y, 823G, 824K, 829R, 833H, 883E, 897N
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
   897N
   putative active site
   788Y, 821Y, 823G, 824K, 829R, 833H, 883E, 897N
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)
4. putative metal bin...
   883E
   putative metal binding site
   883E
   CDD
   cd10454 (GIY-YIG_COG3680_Meta)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0004519 endonuclease activity
GO:0005515 protein binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0