Protein

## Lalb_05669

Length
1,249 amino acids

### Protein family membership

None predicted.

### Homologous superfamilies

1. Homologous superfamily
   27 - 147
   - Pre-ATP-grasp domain superfamily (IPR016185)
   406 - 512
   - Rudiment single hybrid motif (IPR011054)
   536 - 1,111
   - Aldolase-type TIM barrel (IPR013785)
   1,170 - 1,249
   - Single hybrid motif (IPR011053)

1 200 400 600 800 1000 1249

### Domains and repeats

1. Domain
   35 - 510
   - Biotin carboxylation domain (IPR011764)
2. Domain
   36 - 143
   - Biotin carboxylase-like, N-terminal domain (IPR005481)
   149 - 396
   - ATP-grasp fold (IPR011761)
     - Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain (IPR005479)
   412 - 506
   - Biotin carboxylase, C-terminal (IPR005482)
   606 - 877
   - Pyruvate carboxyltransferase (IPR000891)
   932 - 1,128
   - Carboxylase, conserved domain (IPR003379)
   1,180 - 1,249
   - Biotin/lipoyl attachment (IPR000089)

1 200 400 600 800 1000 1249

### Detailed signature matches

1. IPR016185
   Pre-ATP-grasp domain superfamily
   1. SSF52440 (PreATP-gr...)
      27 - 147
      SUPERFAMILY
      SSF52440 (PreATP-grasp domain)
2. IPR011054
   Rudiment single hybrid motif
   1. SSF51246 (Rudiment ...)
      406 - 512
      SUPERFAMILY
      SSF51246 (Rudiment single hybrid motif)
3. IPR013785
   Aldolase-type TIM barrel
   1. G3DSA:3.20.20.70 (A...)
      1,044 - 1,111
      GENE3D
      G3DSA:3.20.20.70 (Aldolase class I)
      536 - 860
      GENE3D
      G3DSA:3.20.20.70 (Aldolase class I)
      889 - 936
      GENE3D
      G3DSA:3.20.20.70 (Aldolase class I)
4. IPR011053
   Single hybrid motif
   1. SSF51230 (Single hy...)
      1,170 - 1,249
      SUPERFAMILY
      SSF51230 (Single hybrid motif)
5. IPR011764
   Biotin carboxylation domain
   1. PS50979 (BC)
      35 - 510
      PROSITE profiles
      PS50979 (BC)
6. IPR005481
   Biotin carboxylase-like, N-terminal domain
   1. PF00289 (Biotin_carb_N)
      36 - 143
      Pfam
      PF00289 (Biotin_carb_N)
7. IPR011761
   ATP-grasp fold
   1. PS50975 (ATP_GRASP)
      154 - 390
      PROSITE profiles
      PS50975 (ATP_GRASP)
8. IPR005479
   Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
   1. PF02786 (CPSase_L_D2)
      149 - 260
      Pfam
      PF02786 (CPSase_L_D2)
      262 - 396
      Pfam
      PF02786 (CPSase_L_D2)
   2. PS00867 (CPSASE_2)
      359 - 366
      PROSITE patterns
      PS00867 (CPSASE_2)
9. IPR005482
   Biotin carboxylase, C-terminal
   1. SM00878 (Biotin_car...)
      412 - 506
      SMART
      SM00878 (Biotin_carb_C_2)
   2. PF02785 (Biotin_carb_C)
      412 - 493
      Pfam
      PF02785 (Biotin_carb_C)
10. IPR000891
    Pyruvate carboxyltransferase
    1. PF00682 (HMGL-like)
       608 - 862
       Pfam
       PF00682 (HMGL-like)
    2. PS50991 (PYR_CT)
       606 - 877
       PROSITE profiles
       PS50991 (PYR_CT)
11. IPR003379
    Carboxylase, conserved domain
    1. PF02436 (PYC_OADA)
       932 - 1,128
       Pfam
       PF02436 (PYC_OADA)
12. IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
       1,180 - 1,249
       PROSITE profiles
       PS50968 (BIOTINYL_LIPOYL)
    2. PF00364 (Biotin_lipoyl)
       1,182 - 1,248
       Pfam
       PF00364 (Biotin_lipoyl)

no IPR
Unintegrated signatures

1. G3DSA:1.10.47...
   937 - 1,043
   GENE3D
   G3DSA:1.10.472.90 (G3DSA:1.10.472.90)
2. G3DSA:2.40.50...
   1,172 - 1,249
   GENE3D
   G3DSA:2.40.50.100 (G3DSA:2.40.50.100)
3. G3DSA:3.10.60... (p...)
   519 - 535
   GENE3D
   G3DSA:3.10.600.10 (pyruvate carboxylase f1077a mutant domain)
   1,112 - 1,163
   GENE3D
   G3DSA:3.10.600.10 (pyruvate carboxylase f1077a mutant domain)
4. G3DSA:3.30.47...
   262 - 514
   GENE3D
   G3DSA:3.30.470.130 (G3DSA:3.30.470.130)
   25 - 261
   GENE3D
   G3DSA:3.30.470.130 (G3DSA:3.30.470.130)
5. PTHR43778 (FAMILY N...)
   261 - 1,248
   PANTHER
   PTHR43778 (FAMILY NOT NAMED)
   31 - 261
   PANTHER
   PTHR43778 (FAMILY NOT NAMED)
6. SSF51569 (Aldolase)
   890 - 940
   SUPERFAMILY
   SSF51569 (Aldolase)
   600 - 861
   SUPERFAMILY
   SSF51569 (Aldolase)
7. SSF56059 (Glutathio...)
   265 - 425
   SUPERFAMILY
   SSF56059 (Glutathione synthetase ATP-binding domain-like)
   149 - 261
   SUPERFAMILY
   SSF56059 (Glutathione synthetase ATP-binding domain-like)
8. SSF89000 (post-HMGL...)
   937 - 1,112
   SUPERFAMILY
   SSF89000 (post-HMGL domain-like)
9. cd06850 (biotinyl_d...)
   1,182 - 1,248
   CDD
   cd06850 (biotinyl_domain)
10. cd07937 (DRE_TIM_PC...)
    608 - 919
    CDD
    cd07937 (DRE_TIM_PC_TC_5S)

### Residue annotation

1. catalytic residues...
   614R
   catalytic residues
   614R, 615D, 648E
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   615D
   catalytic residues
   614R, 615D, 648E
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   648E
   catalytic residues
   614R, 615D, 648E
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
2. active site cd07937
   614R
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   615D
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   618Q
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   648E
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   652G
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   685L
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   687R
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   748S
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   784K
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   814H
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   816H
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   850Q
   active site
   614R, 615D, 618Q, 648E, 652G, 685L, 687R, 748S, 784K, 814H, 816H, 850Q
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
3. metal binding site...
   615D
   metal binding site
   615D, 784K, 814H, 816H
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   784K
   metal binding site
   615D, 784K, 814H, 816H
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   814H
   metal binding site
   615D, 784K, 814H, 816H
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   816H
   metal binding site
   615D, 784K, 814H, 816H
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
4. homodimer binding ...
   791K
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   793K
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   819A
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   821A
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   823V
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   827L
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   828A
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   842D
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   843S
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   845S
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   855A
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   889A
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
   903S
   homodimer binding site
   791K, 793K, 819A, 821A, 823V, 827L, 828A, 842D, 843S, 845S, 855A, 889A, 903S
   CDD
   cd07937 (DRE_TIM_PC_TC_5S)
5. carboxyltransferas...
   1,205G
   carboxyltransferase (CT) interaction site
   1,205G, 1,214M, 1,215K, 1,216M, 1,223P
   CDD
   cd06850 (biotinyl_domain)
   1,214M
   carboxyltransferase (CT) interaction site
   1,205G, 1,214M, 1,215K, 1,216M, 1,223P
   CDD
   cd06850 (biotinyl_domain)
   1,215K
   carboxyltransferase (CT) interaction site
   1,205G, 1,214M, 1,215K, 1,216M, 1,223P
   CDD
   cd06850 (biotinyl_domain)
   1,216M
   carboxyltransferase (CT) interaction site
   1,205G, 1,214M, 1,215K, 1,216M, 1,223P
   CDD
   cd06850 (biotinyl_domain)
   1,223P
   carboxyltransferase (CT) interaction site
   1,205G, 1,214M, 1,215K, 1,216M, 1,223P
   CDD
   cd06850 (biotinyl_domain)
6. biotinylation site...
   1,215K
   biotinylation site
   1,215K
   CDD
   cd06850 (biotinyl_domain)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0046872 metal ion binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0