Protein

## Lalb_03294

Length
476 amino acids

### Protein family membership

- Orotate phosphoribosyltransferase (IPR023031)

- Orotidine 5'-phosphate decarboxylase (IPR014732)

### Homologous superfamilies

1. Homologous superfamily
   3 - 210
   - Phosphoribosyltransferase-like (IPR029057)
   223 - 474
   - Ribulose-phosphate binding barrel (IPR011060)
2. Homologous superfamily
   220 - 476
   - Aldolase-type TIM barrel (IPR013785)

1 50 100 150 200 250 300 350 400 450 476

### Domains and repeats

1. Domain
   19 - 181
   - Phosphoribosyltransferase domain (IPR000836)
     - Orotate phosphoribosyl transferase domain (IPR004467)
   249 - 463
   - Orotidine 5'-phosphate decarboxylase domain (IPR001754)

1 50 100 150 200 250 300 350 400 450 476

### Detailed signature matches

1. IPR029057
   Phosphoribosyltransferase-like
   1. SSF53271 (PRTase-like)
      13 - 203
      SUPERFAMILY
      SSF53271 (PRTase-like)
   2. G3DSA:3.40.50...
      3 - 210
      GENE3D
      G3DSA:3.40.50.2020 (G3DSA:3.40.50.2020)
2. IPR013785
   Aldolase-type TIM barrel
   1. G3DSA:3.20.20.70 (A...)
      220 - 476
      GENE3D
      G3DSA:3.20.20.70 (Aldolase class I)
3. IPR011060
   Ribulose-phosphate binding barrel
   1. SSF51366 (Ribulose-...)
      223 - 474
      SUPERFAMILY
      SSF51366 (Ribulose-phoshate binding barrel)
4. IPR023031
   Orotate phosphoribosyltransferase
   1. MF_01208 (PyrE)
      1 - 238
      HAMAP
      MF_01208 (PyrE)
5. IPR014732
   Orotidine 5'-phosphate decarboxylase
   1. TIGR01740
      251 - 463
      TIGRFAMs
      TIGR01740 (TIGR01740)
6. IPR000836
   Phosphoribosyltransferase domain
   1. cd06223 (PRTases_typeI)
      53 - 176
      CDD
      cd06223 (PRTases_typeI)
   2. PF00156 (Pribosyltran)
      58 - 164
      Pfam
      PF00156 (Pribosyltran)
7. IPR004467
   Orotate phosphoribosyl transferase domain
   1. TIGR00336
      19 - 181
      TIGRFAMs
      TIGR00336 (TIGR00336)
8. IPR001754
   Orotidine 5'-phosphate decarboxylase domain
   1. SM00934 (OMPdecase_2)
      250 - 463
      SMART
      SM00934 (OMPdecase_2)
   2. PF00215 (OMPdecase)
      249 - 463
      Pfam
      PF00215 (OMPdecase)
9. IPR018089
   Orotidine 5'-phosphate decarboxylase, active site
   1. PS00156 (OMPDECASE)
      306 - 319
      PROSITE patterns
      PS00156 (OMPDECASE)

no IPR
Unintegrated signatures

1. PTHR19278 (FAMILY N...)
   7 - 475
   PANTHER
   PTHR19278 (FAMILY NOT NAMED)
2. PTHR19278:SF9 (URID...)
   7 - 475
   PANTHER
   PTHR19278:SF9 (URIDINE 5'-MONOPHOSPHATE SYNTHASE)
3. cd04725 (OMP_decarb...)
   251 - 463
   CDD
   cd04725 (OMP_decarboxylase_like)

### Residue annotation

1. active site cd06223
   78P
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   80T
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   126E
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   127D
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   128V
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   130T
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   131S
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   132G
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   133S
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   134S
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
   158R
   active site
   78P, 80T, 126E, 127D, 128V, 130T, 131S, 132G, 133S, 134S, 158R
   CDD
   cd06223 (PRTases_typeI)
2. active site cd04725
   254A
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   256D
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   278K
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   280H
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   309D
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   311K
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   370M
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   371S
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   415P
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   447G
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   448R
   active site
   254A, 256D, 278K, 280H, 309D, 311K, 370M, 371S, 415P, 447G, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
3. dimer interface cd...
   280H
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   282D
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   283I
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   310R
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   311K
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   313A
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   314D
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   317N
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   318T
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   321L
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   322Q
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   340H
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   341A
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   342V
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   353K
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   370M
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   381Y
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)
   448R
   dimer interface
   280H, 282D, 283I, 310R, 311K, 313A, 314D, 317N, 318T, 321L, 322Q, 340H, 341A, 342V, 353K, 370M, 381Y, 448R
   CDD
   cd04725 (OMP_decarboxylase_like)

### GO term prediction

#### Biological Process

GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0044205 'de novo' UMP biosynthetic process

#### Molecular Function

GO:0003824 catalytic activity
GO:0004588 orotate phosphoribosyltransferase activity
GO:0004590 orotidine-5'-phosphate decarboxylase activity

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0