Protein

## Lalb_00338

Length
1,031 amino acids

### Protein family membership

None predicted.

### Homologous superfamilies

1. Homologous superfamily
   2 - 65
   - EF-hand domain pair (IPR011992)
   89 - 185
   - EF-hand domain pair (IPR011992)
   229 - 327
   - EF-hand domain pair (IPR011992)

1 100 200 300 400 500 600 700 800 900 1031

### Domains and repeats

1. Domain
   1 - 67
   - EH domain (IPR000261)
   92 - 187
   - EH domain (IPR000261)
   232 - 328
   - EH domain (IPR000261)
2. Domain
   131 - 166
   - EF-hand domain (IPR002048)
   238 - 273
   - EF-hand domain (IPR002048)
   276 - 304
   - EF-hand domain (IPR002048)

1 100 200 300 400 500 600 700 800 900 1031

### Detailed signature matches

1. IPR011992
   EF-hand domain pair
   1. SSF47473 (EF-hand)
      229 - 327
      SUPERFAMILY
      SSF47473 (EF-hand)
      89 - 185
      SUPERFAMILY
      SSF47473 (EF-hand)
      2 - 65
      SUPERFAMILY
      SSF47473 (EF-hand)
2. IPR000261
   EH domain
   1. SM00027 (eh_3)
      232 - 327
      SMART
      SM00027 (eh_3)
      1 - 67
      SMART
      SM00027 (eh_3)
      92 - 186
      SMART
      SM00027 (eh_3)
   2. cd00052 (EH)
      103 - 168
      CDD
      cd00052 (EH)
      245 - 309
      CDD
      cd00052 (EH)
   3. PF12763 (EF-hand_4)
      253 - 323
      Pfam
      PF12763 (EF-hand_4)
      96 - 187
      Pfam
      PF12763 (EF-hand_4)
   4. PS50031 (EH)
      1 - 64
      PROSITE profiles
      PS50031 (EH)
      99 - 187
      PROSITE profiles
      PS50031 (EH)
      239 - 328
      PROSITE profiles
      PS50031 (EH)
3. IPR002048
   EF-hand domain
   1. PS50222 (EF_HAND_2)
      131 - 166
      PROSITE profiles
      PS50222 (EF_HAND_2)
      238 - 273
      PROSITE profiles
      PS50222 (EF_HAND_2)
   2. SM00054 (efh_1)
      242 - 270
      SMART
      SM00054 (efh_1)
      276 - 304
      SMART
      SM00054 (efh_1)
      135 - 163
      SMART
      SM00054 (efh_1)
4. IPR018247
   EF-Hand 1, calcium-binding site
   1. PS00018 (EF_HAND_1)
      144 - 156
      PROSITE patterns
      PS00018 (EF_HAND_1)
      251 - 263
      PROSITE patterns
      PS00018 (EF_HAND_1)
5. IPR003903
   Ubiquitin interacting motif
   1. SM00726 (uim)
      1,011 - 1,030
      SMART
      SM00726 (uim)
      986 - 1,005
      SMART
      SM00726 (uim)
   2. PS50330 (UIM)
      1,011 - 1,030
      PROSITE profiles
      PS50330 (UIM)

no IPR
Unintegrated signatures

1. G3DSA:1.10.23...
   1 - 69
   GENE3D
   G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
   75 - 183
   GENE3D
   G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
   228 - 331
   GENE3D
   G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
2. PTHR11216 (EH DOMAIN)
   1 - 758
   PANTHER
   PTHR11216 (EH DOMAIN)
3. PTHR11216:SF126 (EP...)
   1 - 758
   PANTHER
   PTHR11216:SF126 (EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A)
4. SSF57997 (Tropomyosin)
   347 - 527
   SUPERFAMILY
   SSF57997 (Tropomyosin)
5. cd16853 (STAT3_CCD)
   366 - 529
   CDD
   cd16853 (STAT3_CCD)

### Other features

1. Coil
   992 - 1,013
   COILS
   Coil (Coil)
   347 - 500
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   467 - 491
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   932 - 960
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   580 - 739
   MobiDB Lite
   mobidb-lite (disorder_prediction)
3. mobidb-lite (Prolin...)
   671 - 718
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Proline-rich
4. mobidb-lite (Polar)
   473 - 491
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   605 - 631
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   719 - 739
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar

### Residue annotation

1. pseudo EF-hand loo...
   109S
   pseudo EF-hand loop
   109S, 110L, 111K, 117I, 118S, 119G, 120N, 121N
   CDD
   cd00052 (EH)
   110L
   pseudo EF-hand loop
   109S, 110L, 111K, 117I, 118S, 119G, 120N, 121N
   CDD
   cd00052 (EH)
   111K
   pseudo EF-hand loop
   109S, 110L, 111K, 117I, 118S, 119G, 120N, 121N
   CDD
   cd00052 (EH)
   117I
   pseudo EF-hand loop
   109S, 110L, 111K, 117I, 118S, 119G, 120N, 121N
   CDD
   cd00052 (EH)
   118S
   pseudo EF-hand loop
   109S, 110L, 111K, 117I, 118S, 119G, 120N, 121N
   CDD
   cd00052 (EH)
   119G
   pseudo EF-hand loop
   109S, 110L, 111K, 117I, 118S, 119G, 120N, 121N
   CDD
   cd00052 (EH)
   120N
   pseudo EF-hand loop
   109S, 110L, 111K, 117I, 118S, 119G, 120N, 121N
   CDD
   cd00052 (EH)
   121N
   pseudo EF-hand loop
   109S, 110L, 111K, 117I, 118S, 119G, 120N, 121N
   CDD
   cd00052 (EH)
2. peptide binding po...
   126L
   peptide binding pocket
   126L, 136L, 140W
   CDD
   cd00052 (EH)
   136L
   peptide binding pocket
   126L, 136L, 140W
   CDD
   cd00052 (EH)
   140W
   peptide binding pocket
   126L, 136L, 140W
   CDD
   cd00052 (EH)
3. Ca2+ binding site ...
   144D
   Ca2+ binding site
   144D, 146D, 148D, 155E
   CDD
   cd00052 (EH)
   146D
   Ca2+ binding site
   144D, 146D, 148D, 155E
   CDD
   cd00052 (EH)
   148D
   Ca2+ binding site
   144D, 146D, 148D, 155E
   CDD
   cd00052 (EH)
   155E
   Ca2+ binding site
   144D, 146D, 148D, 155E
   CDD
   cd00052 (EH)
4. pseudo EF-hand loo...
   249Q
   pseudo EF-hand loop
   249Q, 250A, 251D, 258V, 259S, 260G, 261L, 262E
   CDD
   cd00052 (EH)
   250A
   pseudo EF-hand loop
   249Q, 250A, 251D, 258V, 259S, 260G, 261L, 262E
   CDD
   cd00052 (EH)
   251D
   pseudo EF-hand loop
   249Q, 250A, 251D, 258V, 259S, 260G, 261L, 262E
   CDD
   cd00052 (EH)
   258V
   pseudo EF-hand loop
   249Q, 250A, 251D, 258V, 259S, 260G, 261L, 262E
   CDD
   cd00052 (EH)
   259S
   pseudo EF-hand loop
   249Q, 250A, 251D, 258V, 259S, 260G, 261L, 262E
   CDD
   cd00052 (EH)
   260G
   pseudo EF-hand loop
   249Q, 250A, 251D, 258V, 259S, 260G, 261L, 262E
   CDD
   cd00052 (EH)
   261L
   pseudo EF-hand loop
   249Q, 250A, 251D, 258V, 259S, 260G, 261L, 262E
   CDD
   cd00052 (EH)
   262E
   pseudo EF-hand loop
   249Q, 250A, 251D, 258V, 259S, 260G, 261L, 262E
   CDD
   cd00052 (EH)
5. peptide binding po...
   267F
   peptide binding pocket
   267F, 277L, 281W
   CDD
   cd00052 (EH)
   277L
   peptide binding pocket
   267F, 277L, 281W
   CDD
   cd00052 (EH)
   281W
   peptide binding pocket
   267F, 277L, 281W
   CDD
   cd00052 (EH)
6. Ca2+ binding site ...
   285D
   Ca2+ binding site
   285D, 287C, 289N, 296Q
   CDD
   cd00052 (EH)
   287C
   Ca2+ binding site
   285D, 287C, 289N, 296Q
   CDD
   cd00052 (EH)
   289N
   Ca2+ binding site
   285D, 287C, 289N, 296Q
   CDD
   cd00052 (EH)
   296Q
   Ca2+ binding site
   285D, 287C, 289N, 296Q
   CDD
   cd00052 (EH)
7. ligand inducing cd...
   442R
   ligand inducing
   442R, 443Q
   CDD
   cd16853 (STAT3_CCD)
   443Q
   ligand inducing
   442R, 443Q
   CDD
   cd16853 (STAT3_CCD)
8. heterodimer interf...
   462K
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   464Q
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   465E
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   468G
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   469L
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   484R
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   485D
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   488N
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   491T
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   492K
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   495Q
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   496D
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   499L
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   502C
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)
   503Q
   heterodimer interface
   462K, 464Q, 465E, 468G, 469L, 484R, 485D, 488N, 491T, 492K, 495Q, 496D, 499L, 502C, 503Q
   CDD
   cd16853 (STAT3_CCD)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0005509 calcium ion binding
GO:0005515 protein binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0