Protein

## Lalb_03292

Length
852 amino acids

### Protein family membership

- Potassium channel, voltage-dependent, EAG/ELK/ERG (IPR003938)
  - Potassium voltage-gated channel subfamily H member 6 (IPR030172)

### Homologous superfamilies

1. Homologous superfamily
   151 - 338
   - Cyclic nucleotide-binding-like (IPR018490)
2. Homologous superfamily
   191 - 355
   - RmlC-like jelly roll fold (IPR014710)

1 100 200 300 400 500 600 700 800 852

### Domains and repeats

1. Domain
   3 - 150
   - Ion transport domain (IPR005821)
   224 - 342
   - Cyclic nucleotide-binding domain (IPR000595)

1 100 200 300 400 500 600 700 800 852

### Detailed signature matches

1. IPR018490
   Cyclic nucleotide-binding-like
   1. SSF51206 (cAMP-bind...)
      151 - 338
      SUPERFAMILY
      SSF51206 (cAMP-binding domain-like)
2. IPR014710
   RmlC-like jelly roll fold
   1. G3DSA:2.60.12... (J...)
      191 - 355
      GENE3D
      G3DSA:2.60.120.10 (Jelly Rolls)
3. IPR003938
   Potassium channel, voltage-dependent, EAG/ELK/ERG
   1. PR01463 (EAGCHANLFMLY)
      93 - 110
      PRINTS
      PR01463 (EAGCHANLFMLY)
      41 - 51
      PRINTS
      PR01463 (EAGCHANLFMLY)
      187 - 194
      PRINTS
      PR01463 (EAGCHANLFMLY)
      119 - 130
      PRINTS
      PR01463 (EAGCHANLFMLY)
      304 - 312
      PRINTS
      PR01463 (EAGCHANLFMLY)
      137 - 146
      PRINTS
      PR01463 (EAGCHANLFMLY)
4. IPR030172
   Potassium voltage-gated channel subfamily H member 6
   1. PTHR10217:SF468 (PO...)
      1 - 712
      PANTHER
      PTHR10217:SF468 (POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 6)
5. IPR005821
   Ion transport domain
   1. PF00520 (Ion_trans)
      3 - 150
      Pfam
      PF00520 (Ion_trans)
6. IPR000595
   Cyclic nucleotide-binding domain
   1. PF00027 (cNMP_binding)
      244 - 325
      Pfam
      PF00027 (cNMP_binding)
   2. cd00038 (CAP_ED)
      224 - 334
      CDD
      cd00038 (CAP_ED)
   3. PS50042 (CNMP_BINDI...)
      224 - 324
      PROSITE profiles
      PS50042 (CNMP_BINDING_3)
   4. SM00100 (cnmp_10)
      224 - 342
      SMART
      SM00100 (cnmp_10)

no IPR
Unintegrated signatures

1. G3DSA:1.10.12...
   145 - 187
   GENE3D
   G3DSA:1.10.1200.260 (G3DSA:1.10.1200.260)
2. G3DSA:1.10.28...
   21 - 144
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
3. PTHR10217 (VOLTAGE ...)
   1 - 712
   PANTHER
   PTHR10217 (VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL)
4. SSF81324 (Voltage-g...)
   6 - 58
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   87 - 188
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)

### Other features

1. Coil
   567 - 587
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   607 - 834
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   516 - 574
   MobiDB Lite
   mobidb-lite (disorder_prediction)
3. mobidb-lite (Polyam...)
   773 - 787
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
4. mobidb-lite (Polar)
   788 - 829
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   523 - 561
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   647 - 727
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar

### Residue annotation

1. ligand binding sit...
   288G
   ligand binding site
   288G, 289E, 300S, 301S, 302C
   CDD
   cd00038 (CAP_ED)
   289E
   ligand binding site
   288G, 289E, 300S, 301S, 302C
   CDD
   cd00038 (CAP_ED)
   300S
   ligand binding site
   288G, 289E, 300S, 301S, 302C
   CDD
   cd00038 (CAP_ED)
   301S
   ligand binding site
   288G, 289E, 300S, 301S, 302C
   CDD
   cd00038 (CAP_ED)
   302C
   ligand binding site
   288G, 289E, 300S, 301S, 302C
   CDD
   cd00038 (CAP_ED)
2. flexible hinge reg...
   322D
   flexible hinge region
   322D, 323V, 324L, 328P, 329E, 330F
   CDD
   cd00038 (CAP_ED)
   323V
   flexible hinge region
   322D, 323V, 324L, 328P, 329E, 330F
   CDD
   cd00038 (CAP_ED)
   324L
   flexible hinge region
   322D, 323V, 324L, 328P, 329E, 330F
   CDD
   cd00038 (CAP_ED)
   328P
   flexible hinge region
   322D, 323V, 324L, 328P, 329E, 330F
   CDD
   cd00038 (CAP_ED)
   329E
   flexible hinge region
   322D, 323V, 324L, 328P, 329E, 330F
   CDD
   cd00038 (CAP_ED)
   330F
   flexible hinge region
   322D, 323V, 324L, 328P, 329E, 330F
   CDD
   cd00038 (CAP_ED)

### GO term prediction

#### Biological Process

GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport

#### Molecular Function

GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity

#### Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane

Generated with InterProScan 5.45-80.0