Protein

## Lalb_04617

Length
112 amino acids

### Protein family membership

- Transcription initiation factor IIA, gamma subunit (IPR003194)

### Homologous superfamilies

1. Homologous superfamily
   2 - 53
   - Transcription factor IIA, helical (IPR009083)
2. Homologous superfamily
   52 - 109
   - Transcription factor IIA, beta-barrel (IPR009088)

1 20 40 60 80 100 112

### Domains and repeats

1. Domain
   2 - 50
   - Transcription initiation factor IIA, gamma subunit, N-terminal (IPR015872)
   56 - 102
   - Transcription initiation factor IIA, gamma subunit, C-terminal (IPR015871)

1 20 40 60 80 100 112

### Detailed signature matches

1. IPR009083
   Transcription factor IIA, helical
   1. G3DSA:1.10.28...
      2 - 53
      GENE3D
      G3DSA:1.10.287.190 (G3DSA:1.10.287.190)
2. IPR009088
   Transcription factor IIA, beta-barrel
   1. SSF50784 (Transcrip...)
      52 - 102
      SUPERFAMILY
      SSF50784 (Transcription factor IIA (TFIIA), beta-barrel domain)
   2. G3DSA:2.30.18.10 (T...)
      54 - 109
      GENE3D
      G3DSA:2.30.18.10 (Transcription factor IIA (TFIIA))
3. IPR003194
   Transcription initiation factor IIA, gamma subunit
   1. PIRSF009415 (TFIIA_...)
      1 - 107
      PIRSF
      PIRSF009415 (TFIIA_gamma_hum)
   2. PTHR10966 (TRANSCRI...)
      1 - 105
      PANTHER
      PTHR10966 (TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2)
4. IPR015872
   Transcription initiation factor IIA, gamma subunit, N-terminal
   1. cd10145 (TFIIA_gamma_N)
      2 - 50
      CDD
      cd10145 (TFIIA_gamma_N)
   2. PF02268 (TFIIA_gamma_N)
      2 - 48
      Pfam
      PF02268 (TFIIA_gamma_N)
5. IPR015871
   Transcription initiation factor IIA, gamma subunit, C-terminal
   1. PF02751 (TFIIA_gamma_C)
      62 - 101
      Pfam
      PF02751 (TFIIA_gamma_C)
   2. cd10014 (TFIIA_gamma_C)
      56 - 102
      CDD
      cd10014 (TFIIA_gamma_C)

no IPR
Unintegrated signatures

1. PTHR10966:SF5 (TRAN...)
   1 - 105
   PANTHER
   PTHR10966:SF5 (TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2)
2. SSF47396 (Transcrip...)
   3 - 53
   SUPERFAMILY
   SSF47396 (Transcription factor IIA (TFIIA), alpha-helical domain)

### Residue annotation

1. TFIIA subunit inte...
   5L
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   6Y
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   9T
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   10T
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   11L
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   14T
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   15L
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   17E
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   18S
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   19L
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   21E
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   22L
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   32L
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   36V
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   39Q
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   43A
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   44I
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   45N
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   47A
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   48L
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
   49A
   TFIIA subunit interface
   5L, 6Y, 9T, 10T, 11L, 14T, 15L, 17E, 18S, 19L, 21E, 22L, 32L, 36V, 39Q, 43A, 44I, 45N, 47A, 48L, 49A
   CDD
   cd10145 (TFIIA_gamma_N)
2. TFIIA subunit inte...
   56L
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   57T
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   58F
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   59K
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   60V
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   61R
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   63L
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   66Y
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   68F
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   71N
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   73W
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   75F
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   82F
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   89A
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   90L
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   91V
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   93K
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   94V
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   95K
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   96I
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   97V
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   98A
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   99C
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
   100D
   TFIIA subunit interface
   56L, 57T, 58F, 59K, 60V, 61R, 63L, 66Y, 68F, 71N, 73W, 75F, 82F, 89A, 90L, 91V, 93K, 94V, 95K, 96I, 97V, 98A, 99C, 100D
   CDD
   cd10014 (TFIIA_gamma_C)
3. TBP interface cd10...
   63L
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)
   64N
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)
   65T
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)
   66Y
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)
   67R
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)
   68F
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)
   69C
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)
   70D
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)
   71N
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)
   73W
   TBP interface
   63L, 64N, 65T, 66Y, 67R, 68F, 69C, 70D, 71N, 73W
   CDD
   cd10014 (TFIIA_gamma_C)

### GO term prediction

#### Biological Process

GO:0006367 transcription initiation from RNA polymerase II promoter

#### Molecular Function

None predicted.

#### Cellular Component

GO:0005672 transcription factor TFIIA complex

Generated with InterProScan 5.45-80.0