Protein

## Lalb_07036

Length
644 amino acids

### Protein family membership

- Microprocessor complex subunit DGCR8 (IPR040375)

### Homologous superfamilies

None predicted.

### Domains and repeats

1. Domain
   364 - 431
   - Double-stranded RNA-binding domain (IPR014720)
   490 - 555
   - Double-stranded RNA-binding domain (IPR014720)

1 100 200 300 400 500 644

### Detailed signature matches

1. IPR040375
   Microprocessor complex subunit DGCR8
   1. PTHR13482 (DGCR8 PR...)
      86 - 643
      PANTHER
      PTHR13482 (DGCR8 PROTEIN DIGEORGE SYNDROME CRITICAL REGION 8)
2. IPR014720
   Double-stranded RNA-binding domain
   1. PS50137 (DS_RBD)
      364 - 431
      PROSITE profiles
      PS50137 (DS_RBD)
   2. SM00358 (DRBM_3)
      490 - 555
      SMART
      SM00358 (DRBM_3)
      365 - 430
      SMART
      SM00358 (DRBM_3)
   3. cd00048 (DSRM)
      365 - 429
      CDD
      cd00048 (DSRM)
   4. PF00035 (dsrm)
      365 - 429
      Pfam
      PF00035 (dsrm)

no IPR
Unintegrated signatures

1. G3DSA:2.20.70.10
   174 - 227
   GENE3D
   G3DSA:2.20.70.10 (G3DSA:2.20.70.10)
2. G3DSA:3.30.16...
   380 - 436
   GENE3D
   G3DSA:3.30.160.20 (G3DSA:3.30.160.20)
   462 - 571
   GENE3D
   G3DSA:3.30.160.20 (G3DSA:3.30.160.20)
3. G3DSA:3.30.16...
   349 - 378
   GENE3D
   G3DSA:3.30.160.590 (G3DSA:3.30.160.590)
4. SSF54768 (dsRNA-bin...)
   489 - 556
   SUPERFAMILY
   SSF54768 (dsRNA-binding domain-like)
   356 - 433
   SUPERFAMILY
   SSF54768 (dsRNA-binding domain-like)

### Other features

1. Coil
   226 - 246
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   1 - 22
   MobiDB Lite
   mobidb-lite (disorder_prediction)

### Residue annotation

1. dsRNA binding site...
   370H
   dsRNA binding site
   370H, 371E, 412S, 413S, 414K, 415K, 418K
   CDD
   cd00048 (DSRM)
   371E
   dsRNA binding site
   370H, 371E, 412S, 413S, 414K, 415K, 418K
   CDD
   cd00048 (DSRM)
   412S
   dsRNA binding site
   370H, 371E, 412S, 413S, 414K, 415K, 418K
   CDD
   cd00048 (DSRM)
   413S
   dsRNA binding site
   370H, 371E, 412S, 413S, 414K, 415K, 418K
   CDD
   cd00048 (DSRM)
   414K
   dsRNA binding site
   370H, 371E, 412S, 413S, 414K, 415K, 418K
   CDD
   cd00048 (DSRM)
   415K
   dsRNA binding site
   370H, 371E, 412S, 413S, 414K, 415K, 418K
   CDD
   cd00048 (DSRM)
   418K
   dsRNA binding site
   370H, 371E, 412S, 413S, 414K, 415K, 418K
   CDD
   cd00048 (DSRM)

### GO term prediction

#### Biological Process

GO:0031053 primary miRNA processing

#### Molecular Function

GO:0003723 RNA binding
GO:0020037 heme binding
GO:0042802 identical protein binding

#### Cellular Component

GO:0070877 microprocessor complex

Generated with InterProScan 5.45-80.0