Protein

## Lalb_08509

Length
241 amino acids

### Protein family membership

- Glutathione Transferase family (IPR040079)
  - Glutathione S-transferase, omega-class (IPR005442)

### Homologous superfamilies

1. Homologous superfamily
   5 - 228
   - Thioredoxin-like superfamily (IPR036249)
2. Homologous superfamily
   99 - 238
   - Glutathione S-transferase, C-terminal domain superfamily (IPR036282)

1 50 100 150 200 241

### Domains and repeats

1. Domain
   18 - 97
   - Glutathione S-transferase, N-terminal (IPR004045)
   102 - 230
   - Glutathione S-transferase, C-terminal-like (IPR010987)

1 50 100 150 200 241

### Detailed signature matches

1. IPR036249
   Thioredoxin-like superfamily
   1. SSF52833 (Thioredox...)
      19 - 119
      SUPERFAMILY
      SSF52833 (Thioredoxin-like)
   2. G3DSA:3.40.30.10 (G...)
      218 - 228
      GENE3D
      G3DSA:3.40.30.10 (Glutaredoxin)
      5 - 98
      GENE3D
      G3DSA:3.40.30.10 (Glutaredoxin)
2. IPR036282
   Glutathione S-transferase, C-terminal domain superfamily
   1. SSF47616 (GST C-ter...)
      99 - 238
      SUPERFAMILY
      SSF47616 (GST C-terminal domain-like)
3. IPR040079
   Glutathione Transferase family
   1. SFLDS00019 (Glutath...)
      20 - 208
      SFLD
      SFLDS00019 (Glutathione_Transferase_(cyto)
4. IPR005442
   Glutathione S-transferase, omega-class
   1. PR01625 (GSTRNSFRASEO)
      158 - 177
      PRINTS
      PR01625 (GSTRNSFRASEO)
      93 - 107
      PRINTS
      PR01625 (GSTRNSFRASEO)
      18 - 33
      PRINTS
      PR01625 (GSTRNSFRASEO)
5. IPR004045
   Glutathione S-transferase, N-terminal
   1. PS50404 (GST_NTER)
      18 - 97
      PROSITE profiles
      PS50404 (GST_NTER)
   2. PF13417 (GST_N_3)
      22 - 95
      Pfam
      PF13417 (GST_N_3)
6. IPR010987
   Glutathione S-transferase, C-terminal-like
   1. PS50405 (GST_CTER)
      102 - 230
      PROSITE profiles
      PS50405 (GST_CTER)

no IPR
Unintegrated signatures

1. G3DSA:1.20.10...
   99 - 217
   GENE3D
   G3DSA:1.20.1050.10 (G3DSA:1.20.1050.10)
2. PF13410 (GST_C_2)
   144 - 203
   Pfam
   PF13410 (GST_C_2)
3. PTHR43968 (FAMILY N...)
   3 - 234
   PANTHER
   PTHR43968 (FAMILY NOT NAMED)
4. SFLDG00358 (Main_(c...)
   20 - 208
   SFLD
   SFLDG00358 (Main_(cytGST))
5. cd03055 (GST_N_Omega)
   2 - 90
   CDD
   cd03055 (GST_N_Omega)
6. cd03184 (GST_C_Omega)
   104 - 229
   CDD
   cd03184 (GST_C_Omega)

### Residue annotation

1. C-terminal domain ...
   4K
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   5H
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   25M
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   26R
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   27F
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   29P
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   32Q
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   33R
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   35H
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   36L
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   37V
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   39D
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   40A
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   51N
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
   53A
   C-terminal domain interface
   4K, 5H, 25M, 26R, 27F, 29P, 32Q, 33R, 35H, 36L, 37V, 39D, 40A, 51N, 53A
   CDD
   cd03055 (GST_N_Omega)
2. active site cystei...
   28C
   active site cysteine
   28C
   CDD
   cd03055 (GST_N_Omega)
3. GSH binding site (...
   28C
   GSH binding site (G-site)
   28C, 30Y, 55K, 67K, 68V, 69P, 81E, 82S
   CDD
   cd03055 (GST_N_Omega)
   30Y
   GSH binding site (G-site)
   28C, 30Y, 55K, 67K, 68V, 69P, 81E, 82S
   CDD
   cd03055 (GST_N_Omega)
   55K
   GSH binding site (G-site)
   28C, 30Y, 55K, 67K, 68V, 69P, 81E, 82S
   CDD
   cd03055 (GST_N_Omega)
   67K
   GSH binding site (G-site)
   28C, 30Y, 55K, 67K, 68V, 69P, 81E, 82S
   CDD
   cd03055 (GST_N_Omega)
   68V
   GSH binding site (G-site)
   28C, 30Y, 55K, 67K, 68V, 69P, 81E, 82S
   CDD
   cd03055 (GST_N_Omega)
   69P
   GSH binding site (G-site)
   28C, 30Y, 55K, 67K, 68V, 69P, 81E, 82S
   CDD
   cd03055 (GST_N_Omega)
   81E
   GSH binding site (G-site)
   28C, 30Y, 55K, 67K, 68V, 69P, 81E, 82S
   CDD
   cd03055 (GST_N_Omega)
   82S
   GSH binding site (G-site)
   28C, 30Y, 55K, 67K, 68V, 69P, 81E, 82S
   CDD
   cd03055 (GST_N_Omega)
4. putative dimer int...
   67K
   putative dimer interface
   67K, 80Y, 81E, 83L, 84V, 87E
   CDD
   cd03055 (GST_N_Omega)
   80Y
   putative dimer interface
   67K, 80Y, 81E, 83L, 84V, 87E
   CDD
   cd03055 (GST_N_Omega)
   81E
   putative dimer interface
   67K, 80Y, 81E, 83L, 84V, 87E
   CDD
   cd03055 (GST_N_Omega)
   83L
   putative dimer interface
   67K, 80Y, 81E, 83L, 84V, 87E
   CDD
   cd03055 (GST_N_Omega)
   84V
   putative dimer interface
   67K, 80Y, 81E, 83L, 84V, 87E
   CDD
   cd03055 (GST_N_Omega)
   87E
   putative dimer interface
   67K, 80Y, 81E, 83L, 84V, 87E
   CDD
   cd03055 (GST_N_Omega)
5. putative dimer int...
   110K
   putative dimer interface
   110K, 111L, 114D, 115R, 118S, 146L
   CDD
   cd03184 (GST_C_Omega)
   111L
   putative dimer interface
   110K, 111L, 114D, 115R, 118S, 146L
   CDD
   cd03184 (GST_C_Omega)
   114D
   putative dimer interface
   110K, 111L, 114D, 115R, 118S, 146L
   CDD
   cd03184 (GST_C_Omega)
   115R
   putative dimer interface
   110K, 111L, 114D, 115R, 118S, 146L
   CDD
   cd03184 (GST_C_Omega)
   118S
   putative dimer interface
   110K, 111L, 114D, 115R, 118S, 146L
   CDD
   cd03184 (GST_C_Omega)
   146L
   putative dimer interface
   110K, 111L, 114D, 115R, 118S, 146L
   CDD
   cd03184 (GST_C_Omega)
6. substrate binding ...
   117N
   substrate binding pocket (H-site)
   117N, 120I, 121S, 124Y, 125K, 174W, 177R, 222H
   CDD
   cd03184 (GST_C_Omega)
   120I
   substrate binding pocket (H-site)
   117N, 120I, 121S, 124Y, 125K, 174W, 177R, 222H
   CDD
   cd03184 (GST_C_Omega)
   121S
   substrate binding pocket (H-site)
   117N, 120I, 121S, 124Y, 125K, 174W, 177R, 222H
   CDD
   cd03184 (GST_C_Omega)
   124Y
   substrate binding pocket (H-site)
   117N, 120I, 121S, 124Y, 125K, 174W, 177R, 222H
   CDD
   cd03184 (GST_C_Omega)
   125K
   substrate binding pocket (H-site)
   117N, 120I, 121S, 124Y, 125K, 174W, 177R, 222H
   CDD
   cd03184 (GST_C_Omega)
   174W
   substrate binding pocket (H-site)
   117N, 120I, 121S, 124Y, 125K, 174W, 177R, 222H
   CDD
   cd03184 (GST_C_Omega)
   177R
   substrate binding pocket (H-site)
   117N, 120I, 121S, 124Y, 125K, 174W, 177R, 222H
   CDD
   cd03184 (GST_C_Omega)
   222H
   substrate binding pocket (H-site)
   117N, 120I, 121S, 124Y, 125K, 174W, 177R, 222H
   CDD
   cd03184 (GST_C_Omega)
7. N-terminal domain ...
   166M
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)
   169F
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)
   170M
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)
   173P
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)
   176E
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)
   177R
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)
   211A
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)
   215S
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)
   225Y
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)
   229R
   N-terminal domain interface
   166M, 169F, 170M, 173P, 176E, 177R, 211A, 215S, 225Y, 229R
   CDD
   cd03184 (GST_C_Omega)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0004364 glutathione transferase activity
GO:0005515 protein binding

#### Cellular Component

GO:0005737 cytoplasm

Generated with InterProScan 5.45-80.0