Protein

## Lalb_13746

Length
455 amino acids

### Protein family membership

- Tubulin (IPR000217)
  - Alpha tubulin (IPR002452)

### Homologous superfamilies

1. Homologous superfamily
   8 - 274
   - Tubulin/FtsZ, GTPase domain superfamily (IPR036525)
   275 - 389
   - Tubulin/FtsZ, C-terminal domain superfamily (IPR037103)
   390 - 443
   - Tubulin, C-terminal (IPR023123)
2. Homologous superfamily
   252 - 441
   - Tubulin/FtsZ, C-terminal (IPR008280)

1 50 100 150 200 250 300 350 400 455

### Domains and repeats

1. Domain
   10 - 252
   - Tubulin/FtsZ, GTPase domain (IPR003008)
   254 - 399
   - Tubulin/FtsZ, 2-layer sandwich domain (IPR018316)

1 50 100 150 200 250 300 350 400 455

### Detailed signature matches

1. IPR036525
   Tubulin/FtsZ, GTPase domain superfamily
   1. G3DSA:3.40.50...
      8 - 274
      GENE3D
      G3DSA:3.40.50.1440 (G3DSA:3.40.50.1440)
   2. SSF52490 (Tubulin n...)
      9 - 250
      SUPERFAMILY
      SSF52490 (Tubulin nucleotide-binding domain-like)
2. IPR008280
   Tubulin/FtsZ, C-terminal
   1. SSF55307 (Tubulin C...)
      252 - 441
      SUPERFAMILY
      SSF55307 (Tubulin C-terminal domain-like)
3. IPR037103
   Tubulin/FtsZ, C-terminal domain superfamily
   1. G3DSA:3.30.13...
      275 - 389
      GENE3D
      G3DSA:3.30.1330.20 (G3DSA:3.30.1330.20)
4. IPR023123
   Tubulin, C-terminal
   1. G3DSA:1.10.28... (H...)
      390 - 443
      GENE3D
      G3DSA:1.10.287.600 (Helix hairpin bin)
5. IPR000217
   Tubulin
   1. PTHR11588 (TUBULIN)
      9 - 451
      PANTHER
      PTHR11588 (TUBULIN)
   2. PR01161 (TUBULIN)
      101 - 112
      PRINTS
      PR01161 (TUBULIN)
      17 - 37
      PRINTS
      PR01161 (TUBULIN)
      59 - 78
      PRINTS
      PR01161 (TUBULIN)
      386 - 414
      PRINTS
      PR01161 (TUBULIN)
      140 - 158
      PRINTS
      PR01161 (TUBULIN)
      159 - 180
      PRINTS
      PR01161 (TUBULIN)
      114 - 138
      PRINTS
      PR01161 (TUBULIN)
      198 - 218
      PRINTS
      PR01161 (TUBULIN)
      184 - 197
      PRINTS
      PR01161 (TUBULIN)
6. IPR002452
   Alpha tubulin
   1. PR01162 (ALPHATUBULIN)
      428 - 444
      PRINTS
      PR01162 (ALPHATUBULIN)
      94 - 107
      PRINTS
      PR01162 (ALPHATUBULIN)
      280 - 295
      PRINTS
      PR01162 (ALPHATUBULIN)
      154 - 166
      PRINTS
      PR01162 (ALPHATUBULIN)
      353 - 366
      PRINTS
      PR01162 (ALPHATUBULIN)
      366 - 385
      PRINTS
      PR01162 (ALPHATUBULIN)
      220 - 232
      PRINTS
      PR01162 (ALPHATUBULIN)
      167 - 178
      PRINTS
      PR01162 (ALPHATUBULIN)
      327 - 348
      PRINTS
      PR01162 (ALPHATUBULIN)
      391 - 407
      PRINTS
      PR01162 (ALPHATUBULIN)
      25 - 40
      PRINTS
      PR01162 (ALPHATUBULIN)
      126 - 134
      PRINTS
      PR01162 (ALPHATUBULIN)
      51 - 64
      PRINTS
      PR01162 (ALPHATUBULIN)
7. IPR003008
   Tubulin/FtsZ, GTPase domain
   1. PF00091 (Tubulin)
      10 - 219
      Pfam
      PF00091 (Tubulin)
   2. SM00864 (Tubulin_4)
      55 - 252
      SMART
      SM00864 (Tubulin_4)
8. IPR018316
   Tubulin/FtsZ, 2-layer sandwich domain
   1. PF03953 (Tubulin_C)
      269 - 398
      Pfam
      PF03953 (Tubulin_C)
   2. SM00865 (Tubulin_C_4)
      254 - 399
      SMART
      SM00865 (Tubulin_C_4)
9. IPR017975
   Tubulin, conserved site
   1. PS00227 (TUBULIN)
      148 - 154
      PROSITE patterns
      PS00227 (TUBULIN)

no IPR
Unintegrated signatures

1. PTHR11588:SF349 (TU...)
   9 - 451
   PANTHER
   PTHR11588:SF349 (TUBULIN ALPHA CHAIN)
2. cd02186 (alpha_tubulin)
   9 - 441
   CDD
   cd02186 (alpha_tubulin)

### Other features

1. Coil
   424 - 444
   COILS
   Coil (Coil)

### Residue annotation

1. beta/alpha domain ...
   9R
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   205D
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   259T
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   260E
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   262Q
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   263T
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   264N
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   266V
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   267P
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   332K
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
   358K
   beta/alpha domain interface
   9R, 205D, 259T, 260E, 262Q, 263T, 264N, 266V, 267P, 332K, 358K
   CDD
   cd02186 (alpha_tubulin)
2. nucleotide binding...
   18Q
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   19A
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   22Q
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   77E
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   107N
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   149G
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   150G
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   151T
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   152G
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   177V
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   212N
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   230Y
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
   234N
   nucleotide binding site
   18Q, 19A, 22Q, 77E, 107N, 149G, 150G, 151T, 152G, 177V, 212N, 230Y, 234N
   CDD
   cd02186 (alpha_tubulin)
3. alpha/beta domain ...
   78P
   alpha/beta domain interface
   78P, 79T, 106A, 107N, 108N, 111R, 187V, 189E, 230Y
   CDD
   cd02186 (alpha_tubulin)
   79T
   alpha/beta domain interface
   78P, 79T, 106A, 107N, 108N, 111R, 187V, 189E, 230Y
   CDD
   cd02186 (alpha_tubulin)
   106A
   alpha/beta domain interface
   78P, 79T, 106A, 107N, 108N, 111R, 187V, 189E, 230Y
   CDD
   cd02186 (alpha_tubulin)
   107N
   alpha/beta domain interface
   78P, 79T, 106A, 107N, 108N, 111R, 187V, 189E, 230Y
   CDD
   cd02186 (alpha_tubulin)
   108N
   alpha/beta domain interface
   78P, 79T, 106A, 107N, 108N, 111R, 187V, 189E, 230Y
   CDD
   cd02186 (alpha_tubulin)
   111R
   alpha/beta domain interface
   78P, 79T, 106A, 107N, 108N, 111R, 187V, 189E, 230Y
   CDD
   cd02186 (alpha_tubulin)
   187V
   alpha/beta domain interface
   78P, 79T, 106A, 107N, 108N, 111R, 187V, 189E, 230Y
   CDD
   cd02186 (alpha_tubulin)
   189E
   alpha/beta domain interface
   78P, 79T, 106A, 107N, 108N, 111R, 187V, 189E, 230Y
   CDD
   cd02186 (alpha_tubulin)
   230Y
   alpha/beta domain interface
   78P, 79T, 106A, 107N, 108N, 111R, 187V, 189E, 230Y
   CDD
   cd02186 (alpha_tubulin)

### GO term prediction

#### Biological Process

GO:0007017 microtubule-based process

#### Molecular Function

GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding

#### Cellular Component

GO:0005874 microtubule

Generated with InterProScan 5.45-80.0