Protein

## Lalb_08522

Length
793 amino acids

### Protein family membership

- Peptidase C2, calpain family (IPR022684)

### Homologous superfamilies

1. Homologous superfamily
   3 - 394
   - Papain-like cysteine peptidase superfamily (IPR038765)
   411 - 545
   - Calpain large subunit, domain III superfamily (IPR036213)
   558 - 727
   - EF-hand domain pair (IPR011992)

1 100 200 300 400 500 600 700 793

### Domains and repeats

1. Domain
   3 - 401
   - Peptidase C2, calpain, catalytic domain (IPR001300)
   409 - 543
   - Peptidase C2, calpain, large subunit, domain III (IPR022682)
     - Peptidase C2, calpain, domain III (IPR022683)
       - Calpain subdomain III (IPR033883)

1 100 200 300 400 500 600 700 793

### Detailed signature matches

1. IPR038765
   Papain-like cysteine peptidase superfamily
   1. SSF54001 (Cysteine ...)
      3 - 165
      SUPERFAMILY
      SSF54001 (Cysteine proteinases)
      235 - 394
      SUPERFAMILY
      SSF54001 (Cysteine proteinases)
2. IPR036213
   Calpain large subunit, domain III superfamily
   1. SSF49758 (Calpain l...)
      411 - 545
      SUPERFAMILY
      SSF49758 (Calpain large subunit, middle domain (domain III))
3. IPR011992
   EF-hand domain pair
   1. SSF47473 (EF-hand)
      558 - 727
      SUPERFAMILY
      SSF47473 (EF-hand)
4. IPR022684
   Peptidase C2, calpain family
   1. PR00704 (CALPAIN)
      2 - 25
      PRINTS
      PR00704 (CALPAIN)
      112 - 137
      PRINTS
      PR00704 (CALPAIN)
      42 - 64
      PRINTS
      PR00704 (CALPAIN)
      509 - 537
      PRINTS
      PR00704 (CALPAIN)
      142 - 165
      PRINTS
      PR00704 (CALPAIN)
      425 - 442
      PRINTS
      PR00704 (CALPAIN)
5. IPR001300
   Peptidase C2, calpain, catalytic domain
   1. PS50203 (CALPAIN_CAT)
      17 - 395
      PROSITE profiles
      PS50203 (CALPAIN_CAT)
   2. cd00044 (CysPc)
      6 - 393
      CDD
      cd00044 (CysPc)
   3. PF00648 (Peptidase_C2)
      234 - 392
      Pfam
      PF00648 (Peptidase_C2)
      18 - 164
      Pfam
      PF00648 (Peptidase_C2)
   4. SM00230 (cys_prot_2)
      3 - 401
      SMART
      SM00230 (cys_prot_2)
6. IPR022682
   Peptidase C2, calpain, large subunit, domain III
   1. PF01067 (Calpain_III)
      418 - 535
      Pfam
      PF01067 (Calpain_III)
7. IPR022683
   Peptidase C2, calpain, domain III
   1. SM00720 (2cal)
      410 - 543
      SMART
      SM00720 (2cal)
8. IPR033883
   Calpain subdomain III
   1. cd00214 (Calpain_III)
      409 - 542
      CDD
      cd00214 (Calpain_III)

no IPR
Unintegrated signatures

1. G3DSA:1.10.23...
   570 - 730
   GENE3D
   G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
2. G3DSA:2.60.12...
   409 - 546
   GENE3D
   G3DSA:2.60.120.380 (G3DSA:2.60.120.380)
3. G3DSA:3.90.70.10 (C...)
   256 - 404
   GENE3D
   G3DSA:3.90.70.10 (Cysteine proteinases)
4. PTHR10183 (CALPAIN)
   233 - 727
   PANTHER
   PTHR10183 (CALPAIN)
   2 - 164
   PANTHER
   PTHR10183 (CALPAIN)
5. PTHR10183:SF394 (CA...)
   2 - 164
   PANTHER
   PTHR10183:SF394 (CALPAIN-C)
   233 - 727
   PANTHER
   PTHR10183:SF394 (CALPAIN-C)
6. cd16197 (EFh_PEF_CalpC)
   569 - 727
   CDD
   cd16197 (EFh_PEF_CalpC)

### Residue annotation

1. catalytic site cd0...
   72K
   catalytic site
   72K, 310I, 335N
   CDD
   cd00044 (CysPc)
   310I
   catalytic site
   72K, 310I, 335N
   CDD
   cd00044 (CysPc)
   335N
   catalytic site
   72K, 310I, 335N
   CDD
   cd00044 (CysPc)
2. putative Ca bindin...
   581H
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   583T
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   588E
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   604S
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   619D
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   621S
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   623S
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   630D
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   649T
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   651E
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   653T
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   660R
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   692R
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   694G
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)
   695D
   putative Ca binding site
   581H, 583T, 588E, 604S, 619D, 621S, 623S, 630D, 649T, 651E, 653T, 660R, 692R, 694G, 695D
   CDD
   cd16197 (EFh_PEF_CalpC)

### GO term prediction

#### Biological Process

GO:0006508 proteolysis

#### Molecular Function

GO:0004198 calcium-dependent cysteine-type endopeptidase activity

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0