Protein

## Lalb_04507

Length
476 amino acids

### Protein family membership

- tRNA-dihydrouridine synthase (IPR001269)

### Homologous superfamilies

1. Homologous superfamily
   24 - 252
   - Aldolase-type TIM barrel (IPR013785)

1 50 100 150 200 250 300 350 400 450 476

### Domains and repeats

1. Domain
   27 - 250
   - DUS-like, FMN-binding domain (IPR035587)

1 50 100 150 200 250 300 350 400 450 476

### Detailed signature matches

1. IPR013785
   Aldolase-type TIM barrel
   1. G3DSA:3.20.20.70 (A...)
      24 - 252
      GENE3D
      G3DSA:3.20.20.70 (Aldolase class I)
2. IPR001269
   tRNA-dihydrouridine synthase
   1. PF01207 (Dus)
      30 - 264
      Pfam
      PF01207 (Dus)
3. IPR035587
   DUS-like, FMN-binding domain
   1. cd02801 (DUS_like_FMN)
      27 - 250
      CDD
      cd02801 (DUS_like_FMN)
4. IPR018517
   tRNA-dihydrouridine synthase, conserved site
   1. PS01136 (UPF0034)
      109 - 127
      PROSITE patterns
      PS01136 (UPF0034)

no IPR
Unintegrated signatures

1. PTHR11082 (TRNA-DIH...)
   15 - 373
   PANTHER
   PTHR11082 (TRNA-DIHYDROURIDINE SYNTHASE)
2. PTHR11082:SF5 (TRNA...)
   15 - 373
   PANTHER
   PTHR11082:SF5 (TRNA-DIHYDROURIDINE(16/17) SYNTHASE [NAD(P)(+)]-LIKE)
3. SSF51395 (FMN-linke...)
   26 - 318
   SUPERFAMILY
   SSF51395 (FMN-linked oxidoreductases)

### Other features

1. mobidb-lite (disord...)
   358 - 379
   MobiDB Lite
   mobidb-lite (disorder_prediction)
2. mobidb-lite (Polyam...)
   359 - 379
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte

### Residue annotation

1. FMN binding site c...
   31A
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   32P
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   33M
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   57M
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   86Q
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   112N
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   154K
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   182H
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   215N
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   217N
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   239A
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
   240E
   FMN binding site
   31A, 32P, 33M, 57M, 86Q, 112N, 154K, 182H, 215N, 217N, 239A, 240E
   CDD
   cd02801 (DUS_like_FMN)
2. active site cd02801
   86Q
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   115C
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   116P
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   154K
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   156R
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   181V
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   182H
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   184R
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   185T
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   216G
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   217N
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
   240E
   active site
   86Q, 115C, 116P, 154K, 156R, 181V, 182H, 184R, 185T, 216G, 217N, 240E
   CDD
   cd02801 (DUS_like_FMN)
3. catalytic residues...
   115C
   catalytic residues
   115C, 156R, 182H, 184R
   CDD
   cd02801 (DUS_like_FMN)
   156R
   catalytic residues
   115C, 156R, 182H, 184R
   CDD
   cd02801 (DUS_like_FMN)
   182H
   catalytic residues
   115C, 156R, 182H, 184R
   CDD
   cd02801 (DUS_like_FMN)
   184R
   catalytic residues
   115C, 156R, 182H, 184R
   CDD
   cd02801 (DUS_like_FMN)
4. substrate binding ...
   116P
   substrate binding site
   116P, 154K, 181V, 185T, 216G, 217N
   CDD
   cd02801 (DUS_like_FMN)
   154K
   substrate binding site
   116P, 154K, 181V, 185T, 216G, 217N
   CDD
   cd02801 (DUS_like_FMN)
   181V
   substrate binding site
   116P, 154K, 181V, 185T, 216G, 217N
   CDD
   cd02801 (DUS_like_FMN)
   185T
   substrate binding site
   116P, 154K, 181V, 185T, 216G, 217N
   CDD
   cd02801 (DUS_like_FMN)
   216G
   substrate binding site
   116P, 154K, 181V, 185T, 216G, 217N
   CDD
   cd02801 (DUS_like_FMN)
   217N
   substrate binding site
   116P, 154K, 181V, 185T, 216G, 217N
   CDD
   cd02801 (DUS_like_FMN)

### GO term prediction

#### Biological Process

GO:0008033 tRNA processing
GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0003824 catalytic activity
GO:0017150 tRNA dihydrouridine synthase activity
GO:0050660 flavin adenine dinucleotide binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0