Protein

## Lalb_01650

Length
393 amino acids

### Protein family membership

- Ribose-phosphate pyrophosphokinase (IPR005946)

### Homologous superfamilies

1. Homologous superfamily
   55 - 381
   - Phosphoribosyltransferase-like (IPR029057)

1 50 100 150 200 250 300 350 393

### Domains and repeats

1. Domain
   55 - 195
   - Ribose-phosphate pyrophosphokinase, N-terminal domain (IPR029099)
   222 - 349
   - Phosphoribosyltransferase domain (IPR000836)

1 50 100 150 200 250 300 350 393

### Detailed signature matches

1. IPR029057
   Phosphoribosyltransferase-like
   1. SSF53271 (PRTase-like)
      120 - 381
      SUPERFAMILY
      SSF53271 (PRTase-like)
      55 - 157
      SUPERFAMILY
      SSF53271 (PRTase-like)
   2. G3DSA:3.40.50...
      222 - 365
      GENE3D
      G3DSA:3.40.50.2020 (G3DSA:3.40.50.2020)
      58 - 154
      GENE3D
      G3DSA:3.40.50.2020 (G3DSA:3.40.50.2020)
      179 - 221
      GENE3D
      G3DSA:3.40.50.2020 (G3DSA:3.40.50.2020)
      366 - 379
      GENE3D
      G3DSA:3.40.50.2020 (G3DSA:3.40.50.2020)
2. IPR005946
   Ribose-phosphate pyrophosphokinase
   1. PF14572 (Pribosyl_s...)
      276 - 388
      Pfam
      PF14572 (Pribosyl_synth)
   2. TIGR01251
      175 - 389
      TIGRFAMs
      TIGR01251 (TIGR01251)
      55 - 156
      TIGRFAMs
      TIGR01251 (TIGR01251)
   3. PTHR10210 (RIBOSE-P...)
      52 - 392
      PANTHER
      PTHR10210 (RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER)
3. IPR029099
   Ribose-phosphate pyrophosphokinase, N-terminal domain
   1. PF13793 (Pribosyltr...)
      55 - 195
      Pfam
      PF13793 (Pribosyltran_N)
4. IPR000836
   Phosphoribosyltransferase domain
   1. cd06223 (PRTases_typeI)
      222 - 349
      CDD
      cd06223 (PRTases_typeI)
5. IPR000842
   Phosphoribosyl pyrophosphate synthetase, conserved site
   1. PS00114 (PRPP_SYNTHASE)
      203 - 218
      PROSITE patterns
      PS00114 (PRPP_SYNTHASE)

no IPR
Unintegrated signatures

1. PTHR10210:SF60 (RIB...)
   52 - 392
   PANTHER
   PTHR10210:SF60 (RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1)
2. SM01400 (Pribosyltr...)
   55 - 195
   SMART
   SM01400 (Pribosyltran_N_2)

### Residue annotation

1. active site cd06223
   246D
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   248G
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   295D
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   296D
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   297M
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   299D
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   300T
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   301C
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   302G
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   303T
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)
   327I
   active site
   246D, 248G, 295D, 296D, 297M, 299D, 300T, 301C, 302G, 303T, 327I
   CDD
   cd06223 (PRTases_typeI)

### GO term prediction

#### Biological Process

GO:0009116 nucleoside metabolic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0044249 cellular biosynthetic process

#### Molecular Function

GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0