Protein

## Lalb_05688

Length
480 amino acids

### Protein family membership

- Voltage-gated potassium channel (IPR028325)
  - Potassium channel, voltage dependent, Kv (IPR003968)
    - Potassium channel, voltage dependent, Kv3 (IPR003974)
      - Potassium channel, voltage dependent, Shaw, invertebrate (IPR015572)

### Homologous superfamilies

1. Homologous superfamily
   10 - 110
   - SKP1/BTB/POZ domain superfamily (IPR011333)
   148 - 310
   - Voltage-dependent channel domain superfamily (IPR027359)

1 50 100 150 200 250 300 350 400 450 480

### Domains and repeats

1. Domain
   10 - 110
   - BTB/POZ domain (IPR000210)
     - Potassium channel tetramerisation-type BTB domain (IPR003131)
   174 - 422
   - Ion transport domain (IPR005821)

1 50 100 150 200 250 300 350 400 450 480

### Detailed signature matches

1. IPR011333
   SKP1/BTB/POZ domain superfamily
   1. SSF54695 (POZ domain)
      10 - 110
      SUPERFAMILY
      SSF54695 (POZ domain)
2. IPR027359
   Voltage-dependent channel domain superfamily
   1. G3DSA:1.20.12...
      148 - 310
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
3. IPR028325
   Voltage-gated potassium channel
   1. PTHR11537 (VOLTAGE-...)
      6 - 455
      PANTHER
      PTHR11537 (VOLTAGE-GATED POTASSIUM CHANNEL)
4. IPR003968
   Potassium channel, voltage dependent, Kv
   1. PR01491 (KVCHANNEL)
      52 - 62
      PRINTS
      PR01491 (KVCHANNEL)
      303 - 311
      PRINTS
      PR01491 (KVCHANNEL)
      327 - 341
      PRINTS
      PR01491 (KVCHANNEL)
      400 - 411
      PRINTS
      PR01491 (KVCHANNEL)
5. IPR003974
   Potassium channel, voltage dependent, Kv3
   1. PR01498 (SHAWCHANNEL)
      53 - 66
      PRINTS
      PR01498 (SHAWCHANNEL)
      68 - 83
      PRINTS
      PR01498 (SHAWCHANNEL)
      425 - 439
      PRINTS
      PR01498 (SHAWCHANNEL)
      86 - 107
      PRINTS
      PR01498 (SHAWCHANNEL)
      164 - 176
      PRINTS
      PR01498 (SHAWCHANNEL)
6. IPR015572
   Potassium channel, voltage dependent, Shaw, invertebrate
   1. PTHR11537:SF257 (PO...)
      6 - 455
      PANTHER
      PTHR11537:SF257 (POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW)
7. IPR000210
   BTB/POZ domain
   1. SM00225 (BTB_4)
      10 - 110
      SMART
      SM00225 (BTB_4)
8. IPR003131
   Potassium channel tetramerisation-type BTB domain
   1. PF02214 (BTB_2)
      12 - 102
      Pfam
      PF02214 (BTB_2)
9. IPR005821
   Ion transport domain
   1. PF00520 (Ion_trans)
      174 - 422
      Pfam
      PF00520 (Ion_trans)

no IPR
Unintegrated signatures

1. G3DSA:1.10.28...
   311 - 422
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
2. G3DSA:3.30.71... (P...)
   6 - 120
   GENE3D
   G3DSA:3.30.710.10 (Potassium Channel Kv1.1; Chain A)
3. PR00169 (KCHANNEL)
   258 - 278
   PRINTS
   PR00169 (KCHANNEL)
   232 - 255
   PRINTS
   PR00169 (KCHANNEL)
   360 - 382
   PRINTS
   PR00169 (KCHANNEL)
   167 - 195
   PRINTS
   PR00169 (KCHANNEL)
   52 - 71
   PRINTS
   PR00169 (KCHANNEL)
   298 - 324
   PRINTS
   PR00169 (KCHANNEL)
   327 - 350
   PRINTS
   PR00169 (KCHANNEL)
   389 - 415
   PRINTS
   PR00169 (KCHANNEL)
4. SSF81324 (Voltage-g...)
   173 - 416
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
5. cd18416 (BTB_Shaw-like)
   9 - 120
   CDD
   cd18416 (BTB_Shaw-like)

### Residue annotation

1. putative tetramer ...
   15N
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   17G
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   18G
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   19I
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   20R
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   21H
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   22E
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   23T
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   24Y
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   27T
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   54F
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   56D
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   57R
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   60G
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   63A
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   67N
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   70R
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   73K
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   75H
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   83P
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   84L
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
   87E
   putative tetramer interface
   15N, 17G, 18G, 19I, 20R, 21H, 22E, 23T, 24Y, 27T, 54F, 56D, 57R, 60G, 63A, 67N, 70R, 73K, 75H, 83P, 84L, 87E
   CDD
   cd18416 (BTB_Shaw-like)
2. Zn binding site cd...
   75H
   Zn binding site
   75H, 81C, 102C, 103C
   CDD
   cd18416 (BTB_Shaw-like)
   81C
   Zn binding site
   75H, 81C, 102C, 103C
   CDD
   cd18416 (BTB_Shaw-like)
   102C
   Zn binding site
   75H, 81C, 102C, 103C
   CDD
   cd18416 (BTB_Shaw-like)
   103C
   Zn binding site
   75H, 81C, 102C, 103C
   CDD
   cd18416 (BTB_Shaw-like)

### GO term prediction

#### Biological Process

GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport

#### Molecular Function

GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding

#### Cellular Component

GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane

Generated with InterProScan 5.45-80.0