Protein

## Lalb_05196

Length
1,110 amino acids

### Protein family membership

- ADAMTS/ADAMTS-like (IPR013273)

### Homologous superfamilies

1. Homologous superfamily
   1 - 201
   - Metallopeptidase, catalytic domain superfamily (IPR024079)
   268 - 324
   - Thrombospondin type-1 (TSP1) repeat superfamily (IPR036383)
   553 - 609
   - Thrombospondin type-1 (TSP1) repeat superfamily (IPR036383)
   668 - 727
   - Thrombospondin type-1 (TSP1) repeat superfamily (IPR036383)
   724 - 780
   - Thrombospondin type-1 (TSP1) repeat superfamily (IPR036383)
   778 - 834
   - Thrombospondin type-1 (TSP1) repeat superfamily (IPR036383)
   867 - 927
   - Thrombospondin type-1 (TSP1) repeat superfamily (IPR036383)
   921 - 982
   - Thrombospondin type-1 (TSP1) repeat superfamily (IPR036383)
   1,000 - 1,070
   - Thrombospondin type-1 (TSP1) repeat superfamily (IPR036383)

1 200 400 600 800 1000 1110

### Domains and repeats

1. Domain
   1 - 183
   - Peptidase M12B, ADAM/reprolysin (IPR001590)
   195 - 261
   - ADAM cysteine-rich domain 2 (IPR041645)
   435 - 545
   - ADAM-TS Spacer 1 (IPR010294)
2. Repeat
   270 - 325
   - Thrombospondin type-1 (TSP1) repeat (IPR000884)
   551 - 610
   - Thrombospondin type-1 (TSP1) repeat (IPR000884)
   670 - 727
   - Thrombospondin type-1 (TSP1) repeat (IPR000884)
   728 - 781
   - Thrombospondin type-1 (TSP1) repeat (IPR000884)
   779 - 835
   - Thrombospondin type-1 (TSP1) repeat (IPR000884)
   869 - 927
   - Thrombospondin type-1 (TSP1) repeat (IPR000884)
   925 - 983
   - Thrombospondin type-1 (TSP1) repeat (IPR000884)
   997 - 1,071
   - Thrombospondin type-1 (TSP1) repeat (IPR000884)

1 200 400 600 800 1000 1110

### Detailed signature matches

1. IPR024079
   Metallopeptidase, catalytic domain superfamily
   1. G3DSA:3.40.39... (C...)
      1 - 201
      GENE3D
      G3DSA:3.40.390.10 (Collagenase (Catalytic Domain))
2. IPR036383
   Thrombospondin type-1 (TSP1) repeat superfamily
   1. SSF82895 (TSP-1 typ...)
      778 - 834
      SUPERFAMILY
      SSF82895 (TSP-1 type 1 repeat)
      553 - 607
      SUPERFAMILY
      SSF82895 (TSP-1 type 1 repeat)
      268 - 324
      SUPERFAMILY
      SSF82895 (TSP-1 type 1 repeat)
      668 - 726
      SUPERFAMILY
      SSF82895 (TSP-1 type 1 repeat)
      921 - 982
      SUPERFAMILY
      SSF82895 (TSP-1 type 1 repeat)
      1,010 - 1,070
      SUPERFAMILY
      SSF82895 (TSP-1 type 1 repeat)
      867 - 926
      SUPERFAMILY
      SSF82895 (TSP-1 type 1 repeat)
      724 - 780
      SUPERFAMILY
      SSF82895 (TSP-1 type 1 repeat)
   2. G3DSA:2.20.10...
      268 - 324
      GENE3D
      G3DSA:2.20.100.10 (G3DSA:2.20.100.10)
      554 - 609
      GENE3D
      G3DSA:2.20.100.10 (G3DSA:2.20.100.10)
      780 - 834
      GENE3D
      G3DSA:2.20.100.10 (G3DSA:2.20.100.10)
      1,000 - 1,070
      GENE3D
      G3DSA:2.20.100.10 (G3DSA:2.20.100.10)
      928 - 982
      GENE3D
      G3DSA:2.20.100.10 (G3DSA:2.20.100.10)
      870 - 927
      GENE3D
      G3DSA:2.20.100.10 (G3DSA:2.20.100.10)
      728 - 779
      GENE3D
      G3DSA:2.20.100.10 (G3DSA:2.20.100.10)
      669 - 727
      GENE3D
      G3DSA:2.20.100.10 (G3DSA:2.20.100.10)
3. IPR013273
   ADAMTS/ADAMTS-like
   1. PR01857 (ADAMTSFAMILY)
      394 - 413
      PRINTS
      PR01857 (ADAMTSFAMILY)
      279 - 297
      PRINTS
      PR01857 (ADAMTSFAMILY)
      414 - 433
      PRINTS
      PR01857 (ADAMTSFAMILY)
4. IPR001590
   Peptidase M12B, ADAM/reprolysin
   1. PS50215 (ADAM_MEPRO)
      1 - 183
      PROSITE profiles
      PS50215 (ADAM_MEPRO)
   2. PF01421 (Reprolysin)
      39 - 183
      Pfam
      PF01421 (Reprolysin)
5. IPR041645
   ADAM cysteine-rich domain 2
   1. PF17771 (ADAM_CR_2)
      195 - 261
      Pfam
      PF17771 (ADAM_CR_2)
6. IPR010294
   ADAM-TS Spacer 1
   1. PF05986 (ADAM_spacer1)
      435 - 545
      Pfam
      PF05986 (ADAM_spacer1)
7. IPR000884
   Thrombospondin type-1 (TSP1) repeat
   1. PS50092 (TSP1)
      779 - 835
      PROSITE profiles
      PS50092 (TSP1)
      997 - 1,071
      PROSITE profiles
      PS50092 (TSP1)
      925 - 983
      PROSITE profiles
      PS50092 (TSP1)
      670 - 727
      PROSITE profiles
      PS50092 (TSP1)
      270 - 325
      PROSITE profiles
      PS50092 (TSP1)
      551 - 610
      PROSITE profiles
      PS50092 (TSP1)
   2. PF00090 (TSP_1)
      274 - 324
      Pfam
      PF00090 (TSP_1)
   3. SM00209 (TSP1_2)
      673 - 727
      SMART
      SM00209 (TSP1_2)
      782 - 835
      SMART
      SM00209 (TSP1_2)
      273 - 325
      SMART
      SM00209 (TSP1_2)
      554 - 610
      SMART
      SM00209 (TSP1_2)
      869 - 927
      SMART
      SM00209 (TSP1_2)
      1,003 - 1,071
      SMART
      SM00209 (TSP1_2)
      728 - 781
      SMART
      SM00209 (TSP1_2)
      928 - 983
      SMART
      SM00209 (TSP1_2)

no IPR
Unintegrated signatures

1. G3DSA:2.60.12...
   419 - 553
   GENE3D
   G3DSA:2.60.120.830 (G3DSA:2.60.120.830)
2. PF19030 (TSP1_ADAMTS)
   872 - 926
   Pfam
   PF19030 (TSP1_ADAMTS)
   674 - 726
   Pfam
   PF19030 (TSP1_ADAMTS)
   555 - 608
   Pfam
   PF19030 (TSP1_ADAMTS)
   729 - 780
   Pfam
   PF19030 (TSP1_ADAMTS)
   929 - 982
   Pfam
   PF19030 (TSP1_ADAMTS)
   783 - 834
   Pfam
   PF19030 (TSP1_ADAMTS)
   1,011 - 1,070
   Pfam
   PF19030 (TSP1_ADAMTS)
3. PTHR13723 (ADAMTS ...)
   1 - 721
   PANTHER
   PTHR13723 (ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE)
   721 - 926
   PANTHER
   PTHR13723 (ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE)
   928 - 1,082
   PANTHER
   PTHR13723 (ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE)
4. PTHR13723:SF278 (AD...)
   1 - 721
   PANTHER
   PTHR13723:SF278 (ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B)
   721 - 926
   PANTHER
   PTHR13723:SF278 (ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B)
   928 - 1,082
   PANTHER
   PTHR13723:SF278 (ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B)
5. SSF55486 (Metallopr...)
   2 - 182
   SUPERFAMILY
   SSF55486 (Metalloproteases ("zincins"), catalytic domain)

### GO term prediction

#### Biological Process

GO:0006508 proteolysis

#### Molecular Function

GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0