Protein

## Lalb_08549

Length
542 amino acids

### Protein family membership

- Aromatic amino acid hydroxylase (IPR001273)
  - Tyrosine 3-monooxygenase-like (IPR019773)
    - Tryptophan 5-monooxygenase (IPR005963)

### Homologous superfamilies

1. Homologous superfamily
   32 - 456
   - Aromatic amino acid hydroxylase superfamily (IPR036951)
2. Homologous superfamily
   145 - 478
   - Aromatic amino acid monoxygenase, C-terminal domain superfamily (IPR036329)

1 50 100 150 200 250 300 350 400 450 500 542

### Domains and repeats

1. Domain
   47 - 126
   - ACT domain (IPR002912)
   133 - 479
   - Aromatic amino acid hydroxylase, C-terminal (IPR019774)
     - Tryptophan 5-hydroxylase, catalytic domain (IPR041904)

1 50 100 150 200 250 300 350 400 450 500 542

### Detailed signature matches

1. IPR036951
   Aromatic amino acid hydroxylase superfamily
   1. G3DSA:1.10.80... (P...)
      32 - 456
      GENE3D
      G3DSA:1.10.800.10 (Phenylalanine Hydroxylase)
2. IPR036329
   Aromatic amino acid monoxygenase, C-terminal domain superfamily
   1. SSF56534 (Aromatic ...)
      145 - 478
      SUPERFAMILY
      SSF56534 (Aromatic aminoacid monoxygenases, catalytic and oligomerization domains)
3. IPR001273
   Aromatic amino acid hydroxylase
   1. PTHR11473 (AROMATIC...)
      41 - 480
      PANTHER
      PTHR11473 (AROMATIC AMINO ACID HYDROXYLASE)
4. IPR019773
   Tyrosine 3-monooxygenase-like
   1. PIRSF000336 (TH)
      18 - 482
      PIRSF
      PIRSF000336 (TH)
5. IPR005963
   Tryptophan 5-monooxygenase
   1. TIGR01270
      40 - 478
      TIGRFAMs
      TIGR01270 (TIGR01270)
6. IPR002912
   ACT domain
   1. PF01842 (ACT)
      47 - 98
      Pfam
      PF01842 (ACT)
   2. PS51671 (ACT)
      48 - 126
      PROSITE profiles
      PS51671 (ACT)
7. IPR019774
   Aromatic amino acid hydroxylase, C-terminal
   1. PS51410 (BH4_AAA_HY...)
      133 - 479
      PROSITE profiles
      PS51410 (BH4_AAA_HYDROXYL_2)
   2. PF00351 (Biopterin_H)
      147 - 476
      Pfam
      PF00351 (Biopterin_H)
   3. PR00372 (FYWHYDRXLASE)
      329 - 348
      PRINTS
      PR00372 (FYWHYDRXLASE)
      435 - 453
      PRINTS
      PR00372 (FYWHYDRXLASE)
      369 - 387
      PRINTS
      PR00372 (FYWHYDRXLASE)
      174 - 193
      PRINTS
      PR00372 (FYWHYDRXLASE)
      400 - 419
      PRINTS
      PR00372 (FYWHYDRXLASE)
      265 - 287
      PRINTS
      PR00372 (FYWHYDRXLASE)
8. IPR041904
   Tryptophan 5-hydroxylase, catalytic domain
   1. cd03346 (eu_TrpOH)
      147 - 431
      CDD
      cd03346 (eu_TrpOH)
9. IPR018301
   Aromatic amino acid hydroxylase, iron/copper binding site
   1. PS00367 (BH4_AAA_HY...)
      308 - 319
      PROSITE patterns
      PS00367 (BH4_AAA_HYDROXYL_1)

no IPR
Unintegrated signatures

1. PTHR11473:SF37 (GH1...)
   41 - 480
   PANTHER
   PTHR11473:SF37 (GH12537P)
2. SSF55021 (ACT-like)
   146 - 152
   SUPERFAMILY
   SSF55021 (ACT-like)
   40 - 118
   SUPERFAMILY
   SSF55021 (ACT-like)
3. cd04929 (ACT_TPH)
   47 - 120
   CDD
   cd04929 (ACT_TPH)

### Other features

1. mobidb-lite (disord...)
   498 - 542
   MobiDB Lite
   mobidb-lite (disorder_prediction)

### Residue annotation

1. putative amino aci...
   58G
   putative amino acid binding site
   58G, 59G, 60L, 61A, 78E, 79S, 80R, 81K
   CDD
   cd04929 (ACT_TPH)
   59G
   putative amino acid binding site
   58G, 59G, 60L, 61A, 78E, 79S, 80R, 81K
   CDD
   cd04929 (ACT_TPH)
   60L
   putative amino acid binding site
   58G, 59G, 60L, 61A, 78E, 79S, 80R, 81K
   CDD
   cd04929 (ACT_TPH)
   61A
   putative amino acid binding site
   58G, 59G, 60L, 61A, 78E, 79S, 80R, 81K
   CDD
   cd04929 (ACT_TPH)
   78E
   putative amino acid binding site
   58G, 59G, 60L, 61A, 78E, 79S, 80R, 81K
   CDD
   cd04929 (ACT_TPH)
   79S
   putative amino acid binding site
   58G, 59G, 60L, 61A, 78E, 79S, 80R, 81K
   CDD
   cd04929 (ACT_TPH)
   80R
   putative amino acid binding site
   58G, 59G, 60L, 61A, 78E, 79S, 80R, 81K
   CDD
   cd04929 (ACT_TPH)
   81K
   putative amino acid binding site
   58G, 59G, 60L, 61A, 78E, 79S, 80R, 81K
   CDD
   cd04929 (ACT_TPH)
2. cofactor binding s...
   274G
   cofactor binding site
   274G, 276L, 281F, 349A, 352Y
   CDD
   cd03346 (eu_TrpOH)
   276L
   cofactor binding site
   274G, 276L, 281F, 349A, 352Y
   CDD
   cd03346 (eu_TrpOH)
   281F
   cofactor binding site
   274G, 276L, 281F, 349A, 352Y
   CDD
   cd03346 (eu_TrpOH)
   349A
   cofactor binding site
   274G, 276L, 281F, 349A, 352Y
   CDD
   cd03346 (eu_TrpOH)
   352Y
   cofactor binding site
   274G, 276L, 281F, 349A, 352Y
   CDD
   cd03346 (eu_TrpOH)
3. metal binding site...
   312H
   metal binding site
   312H, 317H, 357E
   CDD
   cd03346 (eu_TrpOH)
   317H
   metal binding site
   312H, 317H, 357E
   CDD
   cd03346 (eu_TrpOH)
   357E
   metal binding site
   312H, 317H, 357E
   CDD
   cd03346 (eu_TrpOH)

### GO term prediction

#### Biological Process

GO:0009072 aromatic amino acid family metabolic process
GO:0042427 serotonin biosynthetic process
GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0004497 monooxygenase activity
GO:0004510 tryptophan 5-monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0