Protein

## Lalb_01649

Length
199 amino acids

### Protein family membership

None predicted.

### Homologous superfamilies

1. Homologous superfamily
   1 - 160
   - Ubiquitin-conjugating enzyme/RWD-like (IPR016135)
2. Homologous superfamily
   141 - 199
   - UBA-like superfamily (IPR009060)

1 20 40 60 80 100 120 140 160 180 199

### Domains and repeats

1. Domain
   7 - 149
   - Ubiquitin-conjugating enzyme E2 (IPR000608)
   161 - 199
   - Ubiquitin-associated domain (IPR015940)
     - Ubiquitin-conjugating enzyme E2-22kDa (UbcD4) , UBA domain (IPR042614)

1 20 40 60 80 100 120 140 160 180 199

### Detailed signature matches

1. IPR016135
   Ubiquitin-conjugating enzyme/RWD-like
   1. SSF54495 (UBC-like)
      2 - 160
      SUPERFAMILY
      SSF54495 (UBC-like)
   2. G3DSA:3.10.11... (U...)
      1 - 157
      GENE3D
      G3DSA:3.10.110.10 (Ubiquitin Conjugating Enzyme)
2. IPR009060
   UBA-like superfamily
   1. SSF46934 (UBA-like)
      141 - 199
      SUPERFAMILY
      SSF46934 (UBA-like)
3. IPR000608
   Ubiquitin-conjugating enzyme E2
   1. PS50127 (UBIQUITIN_...)
      7 - 143
      PROSITE profiles
      PS50127 (UBIQUITIN_CONJUGAT_2)
   2. cd00195 (UBCc)
      7 - 149
      CDD
      cd00195 (UBCc)
   3. PF00179 (UQ_con)
      8 - 148
      Pfam
      PF00179 (UQ_con)
4. IPR015940
   Ubiquitin-associated domain
   1. SM00165 (uba_6)
      162 - 199
      SMART
      SM00165 (uba_6)
   2. PS50030 (UBA)
      161 - 199
      PROSITE profiles
      PS50030 (UBA)
5. IPR042614
   Ubiquitin-conjugating enzyme E2-22kDa (UbcD4) , UBA domain
   1. cd14391 (UBA_II_E2_...)
      163 - 198
      CDD
      cd14391 (UBA_II_E2_UBCD4)
6. IPR023313
   Ubiquitin-conjugating enzyme, active site
   1. PS00183 (UBIQUITIN_...)
      80 - 96
      PROSITE patterns
      PS00183 (UBIQUITIN_CONJUGAT_1)

no IPR
Unintegrated signatures

1. G3DSA:1.10.8.10 (DN...)
   162 - 199
   GENE3D
   G3DSA:1.10.8.10 (DNA helicase RuvA subunit)
2. PTHR24068 (FAMILY N...)
   5 - 164
   PANTHER
   PTHR24068 (FAMILY NOT NAMED)
3. PTHR24068:SF147 (UB...)
   5 - 164
   PANTHER
   PTHR24068:SF147 (UBIQUITIN-CONJUGATING ENZYME E2 K)
4. SM00212 (ubc_7)
   7 - 154
   SMART
   SM00212 (ubc_7)

### Residue annotation

1. E3 interaction res...
   7Q
   E3 interaction residues
   7Q, 67P, 68F, 102A, 103A
   CDD
   cd00195 (UBCc)
   67P
   E3 interaction residues
   7Q, 67P, 68F, 102A, 103A
   CDD
   cd00195 (UBCc)
   68F
   E3 interaction residues
   7Q, 67P, 68F, 102A, 103A
   CDD
   cd00195 (UBCc)
   102A
   E3 interaction residues
   7Q, 67P, 68F, 102A, 103A
   CDD
   cd00195 (UBCc)
   103A
   E3 interaction residues
   7Q, 67P, 68F, 102A, 103A
   CDD
   cd00195 (UBCc)
2. Ub thioester inter...
   78K
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   79I
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   83N
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   84I
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   87V
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   91I
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   92C
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   93L
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   95I
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   96L
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   100W
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   101A
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   104M
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   109V
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   112S
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   115A
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   118A
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   119A
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   121E
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   123D
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
   124D
   Ub thioester intermediate interaction residues
   78K, 79I, 83N, 84I, 87V, 91I, 92C, 93L, 95I, 96L, 100W, 101A, 104M, 109V, 112S, 115A, 118A, 119A, 121E, 123D, 124D
   CDD
   cd00195 (UBCc)
3. active site cystei...
   92C
   active site cysteine
   92C
   CDD
   cd00195 (UBCc)
4. polypeptide substr...
   171D
   polypeptide substrate binding site
   171D, 172M, 173G, 174I, 191E, 194T, 198F
   CDD
   cd14391 (UBA_II_E2_UBCD4)
   172M
   polypeptide substrate binding site
   171D, 172M, 173G, 174I, 191E, 194T, 198F
   CDD
   cd14391 (UBA_II_E2_UBCD4)
   173G
   polypeptide substrate binding site
   171D, 172M, 173G, 174I, 191E, 194T, 198F
   CDD
   cd14391 (UBA_II_E2_UBCD4)
   174I
   polypeptide substrate binding site
   171D, 172M, 173G, 174I, 191E, 194T, 198F
   CDD
   cd14391 (UBA_II_E2_UBCD4)
   191E
   polypeptide substrate binding site
   171D, 172M, 173G, 174I, 191E, 194T, 198F
   CDD
   cd14391 (UBA_II_E2_UBCD4)
   194T
   polypeptide substrate binding site
   171D, 172M, 173G, 174I, 191E, 194T, 198F
   CDD
   cd14391 (UBA_II_E2_UBCD4)
   198F
   polypeptide substrate binding site
   171D, 172M, 173G, 174I, 191E, 194T, 198F
   CDD
   cd14391 (UBA_II_E2_UBCD4)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0005515 protein binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0