Protein

## Lalb_01680

Length
204 amino acids

### Protein family membership

- DNA-directed RNA polymerase, subunit E/RPC8 (IPR004519)

### Homologous superfamilies

1. Homologous superfamily
   1 - 79
   - RNA polymerase Rpb7-like, N-terminal domain superfamily (IPR036898)
2. Homologous superfamily
   79 - 197
   - Nucleic acid-binding, OB-fold (IPR012340)

1 20 40 60 80 100 120 140 160 180 204

### Domains and repeats

1. Domain
   8 - 64
   - RNA polymerase Rpb7-like , N-terminal (IPR005576)
   83 - 201
   - RNA polymerase III, subunit Rpc25 (IPR013238)

1 20 40 60 80 100 120 140 160 180 204

### Detailed signature matches

1. IPR036898
   RNA polymerase Rpb7-like, N-terminal domain superfamily
   1. G3DSA:3.30.14...
      1 - 79
      GENE3D
      G3DSA:3.30.1490.120 (G3DSA:3.30.1490.120)
   2. SSF88798 (N-termina...)
      1 - 78
      SUPERFAMILY
      SSF88798 (N-terminal, heterodimerisation domain of RBP7 (RpoE))
2. IPR012340
   Nucleic acid-binding, OB-fold
   1. SSF50249 (Nucleic a...)
      79 - 197
      SUPERFAMILY
      SSF50249 (Nucleic acid-binding proteins)
3. IPR004519
   DNA-directed RNA polymerase, subunit E/RPC8
   1. TIGR00448
      1 - 167
      TIGRFAMs
      TIGR00448 (TIGR00448)
4. IPR005576
   RNA polymerase Rpb7-like , N-terminal
   1. PF03876 (SHS2_Rpb7-N)
      8 - 64
      Pfam
      PF03876 (SHS2_Rpb7-N)
5. IPR013238
   RNA polymerase III, subunit Rpc25
   1. PF08292 (RNA_pol_Rbc25)
      83 - 201
      Pfam
      PF08292 (RNA_pol_Rbc25)

no IPR
Unintegrated signatures

1. G3DSA:2.40.50...
   80 - 202
   GENE3D
   G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
2. PTHR12709 (DNA-DIRE...)
   1 - 203
   PANTHER
   PTHR12709 (DNA-DIRECTED RNA POLYMERASE II, III)
3. PTHR12709:SF1 (DNA-...)
   1 - 203
   PANTHER
   PTHR12709:SF1 (DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8)
4. cd04330 (RNAP_III_R...)
   2 - 81
   CDD
   cd04330 (RNAP_III_Rpc25_N)

### Residue annotation

1. Rpc17 interaction ...
   2F
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   3V
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   4L
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   5A
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   6E
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   8K
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   28D
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   31N
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   32R
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   46I
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   47A
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   48L
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   49H
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   73R
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   78R
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)
   80F
   Rpc17 interaction site
   2F, 3V, 4L, 5A, 6E, 8K, 28D, 31N, 32R, 46I, 47A, 48L, 49H, 73R, 78R, 80F
   CDD
   cd04330 (RNAP_III_Rpc25_N)

### GO term prediction

#### Biological Process

GO:0006351 transcription, DNA-templated

#### Molecular Function

GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0