Protein

## Lalb_10732

Length
789 amino acids

### Protein family membership

- Leucine-tRNA ligase (IPR002302)

### Homologous superfamilies

1. Homologous superfamily
   1 - 202
   - Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
   282 - 476
   - Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
   566 - 710
   - Aminoacyl-tRNA synthetase, class Ia, anticodon-binding (IPR009080)

1 100 200 300 400 500 600 700 789

### Domains and repeats

1. Domain
   3 - 133
   - Aminoacyl-tRNA synthetase, class Ia (IPR002300)
   320 - 499
   - Aminoacyl-tRNA synthetase, class Ia (IPR002300)
   608 - 712
   - Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding (IPR013155)

1 100 200 300 400 500 600 700 789

### Detailed signature matches

1. IPR014729
   Rossmann-like alpha/beta/alpha sandwich fold
   1. G3DSA:3.40.50... (HUPs)
      1 - 202
      GENE3D
      G3DSA:3.40.50.620 (HUPs)
      282 - 476
      GENE3D
      G3DSA:3.40.50.620 (HUPs)
2. IPR009080
   Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
   1. SSF47323 (Anticodon...)
      566 - 710
      SUPERFAMILY
      SSF47323 (Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases)
3. IPR002302
   Leucine-tRNA ligase
   1. PR00985 (TRNASYNTHLEU)
      88 - 105
      PRINTS
      PR00985 (TRNASYNTHLEU)
      114 - 130
      PRINTS
      PR00985 (TRNASYNTHLEU)
      463 - 473
      PRINTS
      PR00985 (TRNASYNTHLEU)
      178 - 197
      PRINTS
      PR00985 (TRNASYNTHLEU)
      391 - 409
      PRINTS
      PR00985 (TRNASYNTHLEU)
      430 - 452
      PRINTS
      PR00985 (TRNASYNTHLEU)
      147 - 160
      PRINTS
      PR00985 (TRNASYNTHLEU)
   2. PTHR43740 (FAMILY N...)
      1 - 764
      PANTHER
      PTHR43740 (FAMILY NOT NAMED)
4. IPR002300
   Aminoacyl-tRNA synthetase, class Ia
   1. PF00133 (tRNA-synt_1)
      320 - 499
      Pfam
      PF00133 (tRNA-synt_1)
      3 - 133
      Pfam
      PF00133 (tRNA-synt_1)
5. IPR013155
   Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
   1. PF08264 (Anticodon_1)
      608 - 712
      Pfam
      PF08264 (Anticodon_1)
6. IPR001412
   Aminoacyl-tRNA synthetase, class I, conserved site
   1. PS00178 (AA_TRNA_LI...)
      3 - 14
      PROSITE patterns
      PS00178 (AA_TRNA_LIGASE_I)

no IPR
Unintegrated signatures

1. G3DSA:1.10.73...
   484 - 769
   GENE3D
   G3DSA:1.10.730.10 (G3DSA:1.10.730.10)
2. PTHR43740:SF2 (LEUC...)
   1 - 764
   PANTHER
   PTHR43740:SF2 (LEUCINE--TRNA LIGASE, MITOCHONDRIAL-RELATED)
3. SSF52374 (Nucleotid...)
   319 - 564
   SUPERFAMILY
   SSF52374 (Nucleotidylyl transferase)
   1 - 189
   SUPERFAMILY
   SSF52374 (Nucleotidylyl transferase)
4. cd00812 (LeuRS_core)
   1 - 555
   CDD
   cd00812 (LeuRS_core)

### Other features

1. Coil
   282 - 302
   COILS
   Coil (Coil)

### Residue annotation

1. active site cd00812
   2F
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   4Y
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   10H
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   13H
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   41D
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   49N
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   436G
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   438E
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   439H
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   443H
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   472Q
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   475V
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   517M
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
   519K
   active site
   2F, 4Y, 10H, 13H, 41D, 49N, 436G, 438E, 439H, 443H, 472Q, 475V, 517M, 519K
   CDD
   cd00812 (LeuRS_core)
2. HIGH motif cd00812
   10H
   HIGH motif
   10H, 11M, 12G, 13H
   CDD
   cd00812 (LeuRS_core)
   11M
   HIGH motif
   10H, 11M, 12G, 13H
   CDD
   cd00812 (LeuRS_core)
   12G
   HIGH motif
   10H, 11M, 12G, 13H
   CDD
   cd00812 (LeuRS_core)
   13H
   HIGH motif
   10H, 11M, 12G, 13H
   CDD
   cd00812 (LeuRS_core)
3. KMSKS motif cd00812
   516K
   KMSKS motif
   516K, 517M, 518S, 519K, 520S
   CDD
   cd00812 (LeuRS_core)
   517M
   KMSKS motif
   516K, 517M, 518S, 519K, 520S
   CDD
   cd00812 (LeuRS_core)
   518S
   KMSKS motif
   516K, 517M, 518S, 519K, 520S
   CDD
   cd00812 (LeuRS_core)
   519K
   KMSKS motif
   516K, 517M, 518S, 519K, 520S
   CDD
   cd00812 (LeuRS_core)
   520S
   KMSKS motif
   516K, 517M, 518S, 519K, 520S
   CDD
   cd00812 (LeuRS_core)

### GO term prediction

#### Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation

#### Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005524 ATP binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0