Protein

## Lalb_14738

Length
198 amino acids

### Protein family membership

- Glutathione Transferase family (IPR040079)

### Homologous superfamilies

1. Homologous superfamily
   2 - 196
   - Thioredoxin-like superfamily (IPR036249)
2. Homologous superfamily
   77 - 198
   - Glutathione S-transferase, C-terminal domain superfamily (IPR036282)

1 20 40 60 80 100 120 140 160 180 198

### Domains and repeats

1. Domain
   2 - 79
   - Glutathione S-transferase, N-terminal (IPR004045)
   81 - 198
   - Glutathione S-transferase, C-terminal-like (IPR010987)
     - Glutathione S-transferase, C-terminal (IPR004046)

1 20 40 60 80 100 120 140 160 180 198

### Detailed signature matches

1. IPR036249
   Thioredoxin-like superfamily
   1. SSF52833 (Thioredox...)
      2 - 76
      SUPERFAMILY
      SSF52833 (Thioredoxin-like)
   2. G3DSA:3.40.30.10 (G...)
      4 - 75
      GENE3D
      G3DSA:3.40.30.10 (Glutaredoxin)
      187 - 196
      GENE3D
      G3DSA:3.40.30.10 (Glutaredoxin)
2. IPR036282
   Glutathione S-transferase, C-terminal domain superfamily
   1. SSF47616 (GST C-ter...)
      77 - 198
      SUPERFAMILY
      SSF47616 (GST C-terminal domain-like)
3. IPR040079
   Glutathione Transferase family
   1. SFLDS00019 (Glutath...)
      1 - 198
      SFLD
      SFLDS00019 (Glutathione_Transferase_(cyto)
4. IPR004045
   Glutathione S-transferase, N-terminal
   1. PF02798 (GST_N)
      5 - 72
      Pfam
      PF02798 (GST_N)
   2. PS50404 (GST_NTER)
      2 - 79
      PROSITE profiles
      PS50404 (GST_NTER)
5. IPR010987
   Glutathione S-transferase, C-terminal-like
   1. PS50405 (GST_CTER)
      81 - 198
      PROSITE profiles
      PS50405 (GST_CTER)
6. IPR004046
   Glutathione S-transferase, C-terminal
   1. PF14497 (GST_C_3)
      96 - 197
      Pfam
      PF14497 (GST_C_3)

no IPR
Unintegrated signatures

1. G3DSA:1.20.10...
   76 - 186
   GENE3D
   G3DSA:1.20.1050.10 (G3DSA:1.20.1050.10)
2. PTHR11571 (GLUTATHI...)
   2 - 198
   PANTHER
   PTHR11571 (GLUTATHIONE S-TRANSFERASE)
3. PTHR11571:SF234 (GL...)
   2 - 198
   PANTHER
   PTHR11571:SF234 (GLUTATHIONE S-TRANSFERASE S1)
4. SFLDG01205 (AMPS.1)
   1 - 198
   SFLD
   SFLDG01205 (AMPS.1)
5. cd03039 (GST_N_Sigm...)
   4 - 73
   CDD
   cd03039 (GST_N_Sigma_like)
6. cd03192 (GST_C_Sigm...)
   83 - 184
   CDD
   cd03192 (GST_C_Sigma_like)

### Residue annotation

1. SFLDG01205
   8Y
   8Y
   SFLD
   SFLDG01205 (AMPS.1)
2. GSH binding site (...
   8Y
   GSH binding site (G-site)
   8Y, 14I, 50Q, 51V, 52P, 63Q, 64S
   CDD
   cd03039 (GST_N_Sigma_like)
   14I
   GSH binding site (G-site)
   8Y, 14I, 50Q, 51V, 52P, 63Q, 64S
   CDD
   cd03039 (GST_N_Sigma_like)
   50Q
   GSH binding site (G-site)
   8Y, 14I, 50Q, 51V, 52P, 63Q, 64S
   CDD
   cd03039 (GST_N_Sigma_like)
   51V
   GSH binding site (G-site)
   8Y, 14I, 50Q, 51V, 52P, 63Q, 64S
   CDD
   cd03039 (GST_N_Sigma_like)
   52P
   GSH binding site (G-site)
   8Y, 14I, 50Q, 51V, 52P, 63Q, 64S
   CDD
   cd03039 (GST_N_Sigma_like)
   63Q
   GSH binding site (G-site)
   8Y, 14I, 50Q, 51V, 52P, 63Q, 64S
   CDD
   cd03039 (GST_N_Sigma_like)
   64S
   GSH binding site (G-site)
   8Y, 14I, 50Q, 51V, 52P, 63Q, 64S
   CDD
   cd03039 (GST_N_Sigma_like)
3. C-terminal domain ...
   10P
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   12T
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   13G
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   14I
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   16E
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   17P
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   19R
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   20F
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   23S
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   24Y
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   33R
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   65S
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   69R
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
   72A
   C-terminal domain interface
   10P, 12T, 13G, 14I, 16E, 17P, 19R, 20F, 23S, 24Y, 33R, 65S, 69R, 72A
   CDD
   cd03039 (GST_N_Sigma_like)
4. dimer interface cd...
   49G
   dimer interface
   49G, 62N, 63Q, 65S, 69R, 73K
   CDD
   cd03039 (GST_N_Sigma_like)
   62N
   dimer interface
   49G, 62N, 63Q, 65S, 69R, 73K
   CDD
   cd03039 (GST_N_Sigma_like)
   63Q
   dimer interface
   49G, 62N, 63Q, 65S, 69R, 73K
   CDD
   cd03039 (GST_N_Sigma_like)
   65S
   dimer interface
   49G, 62N, 63Q, 65S, 69R, 73K
   CDD
   cd03039 (GST_N_Sigma_like)
   69R
   dimer interface
   49G, 62N, 63Q, 65S, 69R, 73K
   CDD
   cd03039 (GST_N_Sigma_like)
   73K
   dimer interface
   49G, 62N, 63Q, 65S, 69R, 73K
   CDD
   cd03039 (GST_N_Sigma_like)
5. dimer interface cd...
   83W
   dimer interface
   83W, 85A, 89D, 90I, 93D, 94T, 97D
   CDD
   cd03192 (GST_C_Sigma_like)
   85A
   dimer interface
   83W, 85A, 89D, 90I, 93D, 94T, 97D
   CDD
   cd03192 (GST_C_Sigma_like)
   89D
   dimer interface
   83W, 85A, 89D, 90I, 93D, 94T, 97D
   CDD
   cd03192 (GST_C_Sigma_like)
   90I
   dimer interface
   83W, 85A, 89D, 90I, 93D, 94T, 97D
   CDD
   cd03192 (GST_C_Sigma_like)
   93D
   dimer interface
   83W, 85A, 89D, 90I, 93D, 94T, 97D
   CDD
   cd03192 (GST_C_Sigma_like)
   94T
   dimer interface
   83W, 85A, 89D, 90I, 93D, 94T, 97D
   CDD
   cd03192 (GST_C_Sigma_like)
   97D
   dimer interface
   83W, 85A, 89D, 90I, 93D, 94T, 97D
   CDD
   cd03192 (GST_C_Sigma_like)
6. N-terminal domain ...
   89D
   N-terminal domain interface
   89D, 92V, 96H, 150W, 154T, 157G, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   92V
   N-terminal domain interface
   89D, 92V, 96H, 150W, 154T, 157G, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   96H
   N-terminal domain interface
   89D, 92V, 96H, 150W, 154T, 157G, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   150W
   N-terminal domain interface
   89D, 92V, 96H, 150W, 154T, 157G, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   154T
   N-terminal domain interface
   89D, 92V, 96H, 150W, 154T, 157G, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   157G
   N-terminal domain interface
   89D, 92V, 96H, 150W, 154T, 157G, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   161Y
   N-terminal domain interface
   89D, 92V, 96H, 150W, 154T, 157G, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
7. substrate binding ...
   96H
   substrate binding pocket (H-site)
   96H, 99R, 100L, 103A, 104A, 158F, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   99R
   substrate binding pocket (H-site)
   96H, 99R, 100L, 103A, 104A, 158F, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   100L
   substrate binding pocket (H-site)
   96H, 99R, 100L, 103A, 104A, 158F, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   103A
   substrate binding pocket (H-site)
   96H, 99R, 100L, 103A, 104A, 158F, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   104A
   substrate binding pocket (H-site)
   96H, 99R, 100L, 103A, 104A, 158F, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   158F
   substrate binding pocket (H-site)
   96H, 99R, 100L, 103A, 104A, 158F, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)
   161Y
   substrate binding pocket (H-site)
   96H, 99R, 100L, 103A, 104A, 158F, 161Y
   CDD
   cd03192 (GST_C_Sigma_like)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0005515 protein binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0