Protein

## Lalb_11373

Length
836 amino acids

### Protein family membership

- Chloride channel, voltage gated (IPR001807)

### Homologous superfamilies

1. Homologous superfamily
   139 - 665
   - Chloride channel, core (IPR014743)

1 100 200 300 400 500 600 700 836

### Domains and repeats

1. Domain
   678 - 741
   - CBS domain (IPR000644)
   773 - 830
   - CBS domain (IPR000644)

1 100 200 300 400 500 600 700 836

### Detailed signature matches

1. IPR014743
   Chloride channel, core
   1. SSF81340 (Clc chlor...)
      520 - 665
      SUPERFAMILY
      SSF81340 (Clc chloride channel)
      223 - 487
      SUPERFAMILY
      SSF81340 (Clc chloride channel)
      139 - 184
      SUPERFAMILY
      SSF81340 (Clc chloride channel)
   2. G3DSA:1.10.30... (C...)
      209 - 664
      GENE3D
      G3DSA:1.10.3080.10 (Clc chloride channel)
2. IPR001807
   Chloride channel, voltage gated
   1. PR00762 (CLCHANNEL)
      287 - 306
      PRINTS
      PR00762 (CLCHANNEL)
      256 - 273
      PRINTS
      PR00762 (CLCHANNEL)
      341 - 360
      PRINTS
      PR00762 (CLCHANNEL)
      542 - 562
      PRINTS
      PR00762 (CLCHANNEL)
      649 - 663
      PRINTS
      PR00762 (CLCHANNEL)
      592 - 608
      PRINTS
      PR00762 (CLCHANNEL)
      610 - 629
      PRINTS
      PR00762 (CLCHANNEL)
   2. PF00654 (Voltage_CLC)
      243 - 642
      Pfam
      PF00654 (Voltage_CLC)
3. IPR000644
   CBS domain
   1. PS51371 (CBS)
      678 - 741
      PROSITE profiles
      PS51371 (CBS)
      773 - 830
      PROSITE profiles
      PS51371 (CBS)
   2. SM00116 (cbs_1)
      686 - 736
      SMART
      SM00116 (cbs_1)
      776 - 823
      SMART
      SM00116 (cbs_1)
   3. PF00571 (CBS)
      776 - 822
      Pfam
      PF00571 (CBS)
      689 - 735
      Pfam
      PF00571 (CBS)

no IPR
Unintegrated signatures

1. G3DSA:3.10.58...
   687 - 777
   GENE3D
   G3DSA:3.10.580.20 (G3DSA:3.10.580.20)
2. G3DSA:3.90.12...
   670 - 686
   GENE3D
   G3DSA:3.90.1280.20 (G3DSA:3.90.1280.20)
   778 - 825
   GENE3D
   G3DSA:3.90.1280.20 (G3DSA:3.90.1280.20)
3. PTHR45711 (FAMILY N...)
   75 - 832
   PANTHER
   PTHR45711 (FAMILY NOT NAMED)
4. PTHR45711:SF8 (H(+)...)
   75 - 832
   PANTHER
   PTHR45711:SF8 (H(+)/CL(-) EXCHANGE TRANSPORTER 3)
5. SSF54631 (CBS-domai...)
   665 - 822
   SUPERFAMILY
   SSF54631 (CBS-domain pair)
6. cd03684 (ClC_3_like)
   159 - 662
   CDD
   cd03684 (ClC_3_like)
7. cd04591 (CBS_pair_v...)
   673 - 821
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)

### Residue annotation

1. putative Cl- selec...
   260G
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   261S
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   262G
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   263I
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   264P
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   302G
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   303K
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   304E
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   305G
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   306P
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   545G
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   546L
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   547F
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   548I
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   549P
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
   650Y
   putative Cl- selectivity filter
   260G, 261S, 262G, 263I, 264P, 302G, 303K, 304E, 305G, 306P, 545G, 546L, 547F, 548I, 549P, 650Y
   CDD
   cd03684 (ClC_3_like)
2. putative pore gati...
   304E
   putative pore gating glutamate residue
   304E
   CDD
   cd03684 (ClC_3_like)
3. putative H+/Cl- co...
   361E
   putative H+/Cl- coupling transport residue
   361E
   CDD
   cd03684 (ClC_3_like)
4. ligand binding sit...
   679Q
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   681K
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   686L
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   687H
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   710G
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   711F
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   712P
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   800Q
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   812V
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   814T
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   816K
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   817D
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   820R
   ligand binding site II
   679Q, 681K, 686L, 687H, 710G, 711F, 712P, 800Q, 812V, 814T, 816K, 817D, 820R
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
5. putative ligand bi...
   710G
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   725F
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   729R
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   730D
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   733L
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   778I
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   800Q
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   801T
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   802L
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)
   816K
   putative ligand binding site I
   710G, 725F, 729R, 730D, 733L, 778I, 800Q, 801T, 802L, 816K
   CDD
   cd04591 (CBS_pair_voltage-gated_CLC_euk_bac)

### GO term prediction

#### Biological Process

GO:0006821 chloride transport
GO:0055085 transmembrane transport

#### Molecular Function

GO:0005247 voltage-gated chloride channel activity

#### Cellular Component

GO:0016020 membrane

Generated with InterProScan 5.45-80.0