Protein

## Lalb_05140

Length
622 amino acids

### Protein family membership

None predicted.

### Homologous superfamilies

1. Homologous superfamily
   2 - 161
   - ENTH/VHS (IPR008942)
   206 - 300
   - GAT domain superfamily (IPR038425)
   485 - 621
   - Clathrin adaptor, appendage, Ig-like subdomain superfamily (IPR013041)

1 100 200 300 400 500 622

### Domains and repeats

1. Domain
   6 - 145
   - VHS domain (IPR002014)
   170 - 297
   - GAT domain (IPR004152)
   497 - 620
   - Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (IPR008152)
     - Gamma-adaptin ear (GAE) domain (IPR008153)
2. Domain
   168 - 206
   - GGA, N-GAT domain (IPR041198)

1 100 200 300 400 500 622

### Detailed signature matches

1. IPR008942
   ENTH/VHS
   1. SSF48464 (ENTH/VHS ...)
      7 - 143
      SUPERFAMILY
      SSF48464 (ENTH/VHS domain)
   2. G3DSA:1.25.40.90
      2 - 161
      GENE3D
      G3DSA:1.25.40.90 (G3DSA:1.25.40.90)
2. IPR038425
   GAT domain superfamily
   1. G3DSA:1.20.58...
      206 - 300
      GENE3D
      G3DSA:1.20.58.160 (G3DSA:1.20.58.160)
3. IPR013041
   Clathrin adaptor, appendage, Ig-like subdomain superfamily
   1. SSF49348 (Clathrin ...)
      485 - 621
      SUPERFAMILY
      SSF49348 (Clathrin adaptor appendage domain)
4. IPR002014
   VHS domain
   1. PS50179 (VHS)
      15 - 145
      PROSITE profiles
      PS50179 (VHS)
   2. PF00790 (VHS)
      6 - 141
      Pfam
      PF00790 (VHS)
   3. SM00288 (VHS_2)
      8 - 141
      SMART
      SM00288 (VHS_2)
5. IPR041198
   GGA, N-GAT domain
   1. PF18308 (GGA_N-GAT)
      168 - 206
      Pfam
      PF18308 (GGA_N-GAT)
6. IPR004152
   GAT domain
   1. PS50909 (GAT)
      170 - 297
      PROSITE profiles
      PS50909 (GAT)
   2. PF03127 (GAT)
      221 - 296
      Pfam
      PF03127 (GAT)
7. IPR008152
   Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
   1. PF02883 (Alpha_adap...)
      506 - 620
      Pfam
      PF02883 (Alpha_adaptinC2)
   2. SM00809 (alpha_adap...)
      497 - 620
      SMART
      SM00809 (alpha_adaptinc2)
8. IPR008153
   Gamma-adaptin ear (GAE) domain
   1. PS50180 (GAE)
      501 - 620
      PROSITE profiles
      PS50180 (GAE)

no IPR
Unintegrated signatures

1. G3DSA:1.20.5.170
   162 - 205
   GENE3D
   G3DSA:1.20.5.170 (G3DSA:1.20.5.170)
2. G3DSA:2.60.40...
   478 - 622
   GENE3D
   G3DSA:2.60.40.1230 (G3DSA:2.60.40.1230)
3. PTHR45905 (FAMILY N...)
   4 - 621
   PANTHER
   PTHR45905 (FAMILY NOT NAMED)
4. PTHR45905:SF1 (GOLG...)
   4 - 621
   PANTHER
   PTHR45905:SF1 (GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN)
5. SSF89009 (GAT-like ...)
   171 - 296
   SUPERFAMILY
   SSF89009 (GAT-like domain)
6. cd03567 (VHS_GGA_me...)
   7 - 145
   CDD
   cd03567 (VHS_GGA_metazoan)
7. cd14234 (GAT_GGA_meta)
   212 - 292
   CDD
   cd14234 (GAT_GGA_meta)

### Residue annotation

1. dimer interface cd...
   9E
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   13Q
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   18P
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   47K
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   51L
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   52H
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   54Q
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   55S
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   56S
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   57N
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
   104K
   dimer interface
   9E, 13Q, 18P, 47K, 51L, 52H, 54Q, 55S, 56S, 57N, 104K
   CDD
   cd03567 (VHS_GGA_metazoan)
2. putative intraprot...
   25V
   putative intraprotein/interprotein binding site
   25V, 26A, 29E, 33V, 73R, 74R
   CDD
   cd03567 (VHS_GGA_metazoan)
   26A
   putative intraprotein/interprotein binding site
   25V, 26A, 29E, 33V, 73R, 74R
   CDD
   cd03567 (VHS_GGA_metazoan)
   29E
   putative intraprotein/interprotein binding site
   25V, 26A, 29E, 33V, 73R, 74R
   CDD
   cd03567 (VHS_GGA_metazoan)
   33V
   putative intraprotein/interprotein binding site
   25V, 26A, 29E, 33V, 73R, 74R
   CDD
   cd03567 (VHS_GGA_metazoan)
   73R
   putative intraprotein/interprotein binding site
   25V, 26A, 29E, 33V, 73R, 74R
   CDD
   cd03567 (VHS_GGA_metazoan)
   74R
   putative intraprotein/interprotein binding site
   25V, 26A, 29E, 33V, 73R, 74R
   CDD
   cd03567 (VHS_GGA_metazoan)
3. acidic-cluster-dil...
   85K
   acidic-cluster-dileucine motif interaction site
   85K, 86F, 87R, 90N, 99K, 100Y, 129K, 136M, 140Q
   CDD
   cd03567 (VHS_GGA_metazoan)
   86F
   acidic-cluster-dileucine motif interaction site
   85K, 86F, 87R, 90N, 99K, 100Y, 129K, 136M, 140Q
   CDD
   cd03567 (VHS_GGA_metazoan)
   87R
   acidic-cluster-dileucine motif interaction site
   85K, 86F, 87R, 90N, 99K, 100Y, 129K, 136M, 140Q
   CDD
   cd03567 (VHS_GGA_metazoan)
   90N
   acidic-cluster-dileucine motif interaction site
   85K, 86F, 87R, 90N, 99K, 100Y, 129K, 136M, 140Q
   CDD
   cd03567 (VHS_GGA_metazoan)
   99K
   acidic-cluster-dileucine motif interaction site
   85K, 86F, 87R, 90N, 99K, 100Y, 129K, 136M, 140Q
   CDD
   cd03567 (VHS_GGA_metazoan)
   100Y
   acidic-cluster-dileucine motif interaction site
   85K, 86F, 87R, 90N, 99K, 100Y, 129K, 136M, 140Q
   CDD
   cd03567 (VHS_GGA_metazoan)
   129K
   acidic-cluster-dileucine motif interaction site
   85K, 86F, 87R, 90N, 99K, 100Y, 129K, 136M, 140Q
   CDD
   cd03567 (VHS_GGA_metazoan)
   136M
   acidic-cluster-dileucine motif interaction site
   85K, 86F, 87R, 90N, 99K, 100Y, 129K, 136M, 140Q
   CDD
   cd03567 (VHS_GGA_metazoan)
   140Q
   acidic-cluster-dileucine motif interaction site
   85K, 86F, 87R, 90N, 99K, 100Y, 129K, 136M, 140Q
   CDD
   cd03567 (VHS_GGA_metazoan)
4. ubiquitin binding ...
   219S
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   222N
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   223N
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   226L
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   229E
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   230M
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   233S
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   242E
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   243D
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   245E
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   246L
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   249E
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   250L
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
   253A
   ubiquitin binding site
   219S, 222N, 223N, 226L, 229E, 230M, 233S, 242E, 243D, 245E, 246L, 249E, 250L, 253A
   CDD
   cd14234 (GAT_GGA_meta)
5. Rabaptin5 binding ...
   255E
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   258K
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   259P
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   261V
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   262L
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   263R
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   265A
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   266N
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   268T
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   270D
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   272E
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   279L
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   282S
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   283D
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)
   286G
   Rabaptin5 binding site
   255E, 258K, 259P, 261V, 262L, 263R, 265A, 266N, 268T, 270D, 272E, 279L, 282S, 283D, 286G
   CDD
   cd14234 (GAT_GGA_meta)

### GO term prediction

#### Biological Process

GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

#### Molecular Function

None predicted.

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0