Protein

## Lalb_14034

Length
447 amino acids

### Protein family membership

- Fatty acyl-CoA reductase (IPR026055)

### Homologous superfamilies

1. Homologous superfamily
   47 - 262
   - NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 350 400 447

### Domains and repeats

1. Domain
   1 - 252
   - Male sterility, NAD-binding (IPR013120)
   325 - 444
   - Fatty acyl-CoA reductase, C-terminal (IPR033640)

1 50 100 150 200 250 300 350 400 447

### Detailed signature matches

1. IPR036291
   NAD(P)-binding domain superfamily
   1. SSF51735 (NAD(P)-bi...)
      47 - 126
      SUPERFAMILY
      SSF51735 (NAD(P)-binding Rossmann-fold domains)
      167 - 262
      SUPERFAMILY
      SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. IPR026055
   Fatty acyl-CoA reductase
   1. PTHR11011 (MALE STE...)
      1 - 342
      PANTHER
      PTHR11011 (MALE STERILITY PROTEIN 2-RELATED)
      346 - 446
      PANTHER
      PTHR11011 (MALE STERILITY PROTEIN 2-RELATED)
3. IPR013120
   Male sterility, NAD-binding
   1. PF07993 (NAD_binding_4)
      1 - 252
      Pfam
      PF07993 (NAD_binding_4)
4. IPR033640
   Fatty acyl-CoA reductase, C-terminal
   1. cd09071 (FAR_C)
      325 - 442
      CDD
      cd09071 (FAR_C)
   2. PF03015 (Sterile)
      326 - 444
      Pfam
      PF03015 (Sterile)

no IPR
Unintegrated signatures

1. G3DSA:3.40.50...
   1 - 315
   GENE3D
   G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
2. PTHR11011:SF60 (FAT...)
   1 - 342
   PANTHER
   PTHR11011:SF60 (FATTY ACYL-COA REDUCTASE-RELATED)
   346 - 446
   PANTHER
   PTHR11011:SF60 (FATTY ACYL-COA REDUCTASE-RELATED)
3. cd05236 (FAR-N_SDR_e)
   1 - 283
   CDD
   cd05236 (FAR-N_SDR_e)

### Residue annotation

1. active site cd05236
   99T
   active site
   99T, 121T, 172Y, 176K
   CDD
   cd05236 (FAR-N_SDR_e)
   121T
   active site
   99T, 121T, 172Y, 176K
   CDD
   cd05236 (FAR-N_SDR_e)
   172Y
   active site
   99T, 121T, 172Y, 176K
   CDD
   cd05236 (FAR-N_SDR_e)
   176K
   active site
   99T, 121T, 172Y, 176K
   CDD
   cd05236 (FAR-N_SDR_e)
2. putative substrate...
   121T
   putative substrate binding site
   121T, 172Y, 199I, 211W, 227L, 233M
   CDD
   cd05236 (FAR-N_SDR_e)
   172Y
   putative substrate binding site
   121T, 172Y, 199I, 211W, 227L, 233M
   CDD
   cd05236 (FAR-N_SDR_e)
   199I
   putative substrate binding site
   121T, 172Y, 199I, 211W, 227L, 233M
   CDD
   cd05236 (FAR-N_SDR_e)
   211W
   putative substrate binding site
   121T, 172Y, 199I, 211W, 227L, 233M
   CDD
   cd05236 (FAR-N_SDR_e)
   227L
   putative substrate binding site
   121T, 172Y, 199I, 211W, 227L, 233M
   CDD
   cd05236 (FAR-N_SDR_e)
   233M
   putative substrate binding site
   121T, 172Y, 199I, 211W, 227L, 233M
   CDD
   cd05236 (FAR-N_SDR_e)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0