Protein

## Lalb_13750

Length
620 amino acids

### Protein family membership

None predicted.

### Homologous superfamilies

1. Homologous superfamily
   127 - 309
   - Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
   311 - 434
   - Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
   447 - 593
   - Aminoacyl-tRNA synthetase, class Ia, anticodon-binding (IPR009080)

1 100 200 300 400 500 620

### Domains and repeats

1. Domain
   129 - 459
   - Methionyl/Leucyl tRNA synthetase (IPR015413)
     - Methioninyl-tRNA synthetase core domain (IPR033911)
2. Domain
   443 - 578
   - Methionyl-tRNA synthetase, anticodon-binding domain (IPR041872)

1 100 200 300 400 500 620

### Detailed signature matches

1. IPR014729
   Rossmann-like alpha/beta/alpha sandwich fold
   1. G3DSA:3.40.50... (HUPs)
      127 - 309
      GENE3D
      G3DSA:3.40.50.620 (HUPs)
      311 - 434
      GENE3D
      G3DSA:3.40.50.620 (HUPs)
2. IPR009080
   Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
   1. SSF47323 (Anticodon...)
      447 - 593
      SUPERFAMILY
      SSF47323 (Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases)
3. IPR015413
   Methionyl/Leucyl tRNA synthetase
   1. PF09334 (tRNA-synt_1g)
      130 - 263
      Pfam
      PF09334 (tRNA-synt_1g)
      309 - 459
      Pfam
      PF09334 (tRNA-synt_1g)
4. IPR033911
   Methioninyl-tRNA synthetase core domain
   1. PR01041 (TRNASYNTHMET)
      164 - 178
      PRINTS
      PR01041 (TRNASYNTHMET)
      354 - 369
      PRINTS
      PR01041 (TRNASYNTHMET)
      446 - 457
      PRINTS
      PR01041 (TRNASYNTHMET)
      132 - 145
      PRINTS
      PR01041 (TRNASYNTHMET)
   2. cd00814 (MetRS_core)
      129 - 434
      CDD
      cd00814 (MetRS_core)
5. IPR041872
   Methionyl-tRNA synthetase, anticodon-binding domain
   1. cd07957 (Anticodon_...)
      443 - 578
      CDD
      cd07957 (Anticodon_Ia_Met)

no IPR
Unintegrated signatures

1. G3DSA:1.10.73...
   436 - 620
   GENE3D
   G3DSA:1.10.730.10 (G3DSA:1.10.730.10)
2. PTHR43326 (FAMILY N...)
   305 - 591
   PANTHER
   PTHR43326 (FAMILY NOT NAMED)
   127 - 305
   PANTHER
   PTHR43326 (FAMILY NOT NAMED)
3. PTHR43326:SF1 (METH...)
   127 - 305
   PANTHER
   PTHR43326:SF1 (METHIONINE--TRNA LIGASE, MITOCHONDRIAL)
   305 - 591
   PANTHER
   PTHR43326:SF1 (METHIONINE--TRNA LIGASE, MITOCHONDRIAL)
4. SSF52374 (Nucleotid...)
   128 - 450
   SUPERFAMILY
   SSF52374 (Nucleotidylyl transferase)

### Residue annotation

1. active site cd00814
   135P
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
   136I
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
   138Y
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
   175D
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
   327W
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
   330A
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
   331L
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
   334Y
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
   360I
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
   364H
   active site
   135P, 136I, 138Y, 175D, 327W, 330A, 331L, 334Y, 360I, 364H
   CDD
   cd00814 (MetRS_core)
2. HIGH motif cd00814
   144H
   HIGH motif
   144H, 145V, 146G, 147H
   CDD
   cd00814 (MetRS_core)
   145V
   HIGH motif
   144H, 145V, 146G, 147H
   CDD
   cd00814 (MetRS_core)
   146G
   HIGH motif
   144H, 145V, 146G, 147H
   CDD
   cd00814 (MetRS_core)
   147H
   HIGH motif
   144H, 145V, 146G, 147H
   CDD
   cd00814 (MetRS_core)
3. KMSKS motif cd00814
   395K
   KMSKS motif
   395K, 396M, 397S, 398K, 399S
   CDD
   cd00814 (MetRS_core)
   396M
   KMSKS motif
   395K, 396M, 397S, 398K, 399S
   CDD
   cd00814 (MetRS_core)
   397S
   KMSKS motif
   395K, 396M, 397S, 398K, 399S
   CDD
   cd00814 (MetRS_core)
   398K
   KMSKS motif
   395K, 396M, 397S, 398K, 399S
   CDD
   cd00814 (MetRS_core)
   399S
   KMSKS motif
   395K, 396M, 397S, 398K, 399S
   CDD
   cd00814 (MetRS_core)
4. tRNA binding surfa...
   444N
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   451F
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   452G
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   455L
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   456N
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   459L
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   460G
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   463I
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   464N
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   467R
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   522N
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   523R
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   525F
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   526D
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   531W
   tRNA binding surface
   444N, 451F, 452G, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 522N, 523R, 525F, 526D, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
5. anticodon binding ...
   451F
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   455L
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   456N
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   459L
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   460G
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   463I
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   464N
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   467R
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   525F
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)
   531W
   anticodon binding site
   451F, 455L, 456N, 459L, 460G, 463I, 464N, 467R, 525F, 531W
   CDD
   cd07957 (Anticodon_Ia_Met)

### GO term prediction

#### Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

#### Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0