Protein

## Lalb_10743

Length
1,152 amino acids

### Protein family membership

None predicted.

### Homologous superfamilies

1. Homologous superfamily
   84 - 417
   - Papain-like cysteine peptidase superfamily (IPR038765)
   586 - 673
   - DUSP-like superfamily (IPR035927)
   870 - 956
   - DUSP-like superfamily (IPR035927)
   1,033 - 1,094
   - Ubiquitin-like domain superfamily (IPR029071)

1 200 400 600 800 1000 1152

### Domains and repeats

1. Domain
   88 - 414
   - Ubiquitin specific protease domain (IPR028889)
     - Peptidase C19, ubiquitin carboxyl-terminal hydrolase (IPR001394)
       - Ubiquitin-specific peptidase 48 (IPR033841)
   583 - 678
   - Peptidase C19, ubiquitin-specific peptidase, DUSP domain (IPR006615)
   694 - 830
   - Peptidase C19, ubiquitin-specific peptidase, DUSP domain (IPR006615)
   849 - 961
   - Peptidase C19, ubiquitin-specific peptidase, DUSP domain (IPR006615)

1 200 400 600 800 1000 1152

### Detailed signature matches

1. IPR038765
   Papain-like cysteine peptidase superfamily
   1. SSF54001 (Cysteine ...)
      84 - 417
      SUPERFAMILY
      SSF54001 (Cysteine proteinases)
2. IPR035927
   DUSP-like superfamily
   1. SSF143791 (DUSP-like)
      586 - 673
      SUPERFAMILY
      SSF143791 (DUSP-like)
      870 - 956
      SUPERFAMILY
      SSF143791 (DUSP-like)
3. IPR029071
   Ubiquitin-like domain superfamily
   1. SSF54236 (Ubiquitin...)
      1,033 - 1,094
      SUPERFAMILY
      SSF54236 (Ubiquitin-like)
4. IPR028889
   Ubiquitin specific protease domain
   1. PS50235 (USP_3)
      88 - 414
      PROSITE profiles
      PS50235 (USP_3)
5. IPR001394
   Peptidase C19, ubiquitin carboxyl-terminal hydrolase
   1. PF00443 (UCH)
      88 - 411
      Pfam
      PF00443 (UCH)
6. IPR033841
   Ubiquitin-specific peptidase 48
   1. cd02668 (Peptidase_...)
      89 - 412
      CDD
      cd02668 (Peptidase_C19L)
7. IPR006615
   Peptidase C19, ubiquitin-specific peptidase, DUSP domain
   1. PS51283 (DUSP)
      849 - 961
      PROSITE profiles
      PS51283 (DUSP)
      583 - 678
      PROSITE profiles
      PS51283 (DUSP)
      694 - 830
      PROSITE profiles
      PS51283 (DUSP)
8. IPR018200
   Ubiquitin specific protease, conserved site
   1. PS00972 (USP_1)
      89 - 104
      PROSITE patterns
      PS00972 (USP_1)
   2. PS00973 (USP_2)
      334 - 352
      PROSITE patterns
      PS00973 (USP_2)

no IPR
Unintegrated signatures

1. G3DSA:3.10.20.90
   1,027 - 1,106
   GENE3D
   G3DSA:3.10.20.90 (G3DSA:3.10.20.90)
2. G3DSA:3.30.22...
   840 - 959
   GENE3D
   G3DSA:3.30.2230.10 (G3DSA:3.30.2230.10)
3. G3DSA:3.90.70.10 (C...)
   80 - 416
   GENE3D
   G3DSA:3.90.70.10 (Cysteine proteinases)
4. PTHR24006 (FAMILY N...)
   9 - 845
   PANTHER
   PTHR24006 (FAMILY NOT NAMED)
5. PTHR24006:SF722 (UB...)
   9 - 845
   PANTHER
   PTHR24006:SF722 (UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48)
6. cd01795 (Ubl_USP48)
   1,028 - 1,121
   CDD
   cd01795 (Ubl_USP48)

### Other features

1. Coil
   837 - 857
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   1,104 - 1,152
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   420 - 465
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   1,006 - 1,032
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   743 - 776
   MobiDB Lite
   mobidb-lite (disorder_prediction)
3. mobidb-lite (Polyam...)
   420 - 460
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte

### Residue annotation

1. Active Site cd02668
   92N
   Active Site
   92N, 97C, 351H, 368D
   CDD
   cd02668 (Peptidase_C19L)
   97C
   Active Site
   92N, 97C, 351H, 368D
   CDD
   cd02668 (Peptidase_C19L)
   351H
   Active Site
   92N, 97C, 351H, 368D
   CDD
   cd02668 (Peptidase_C19L)
   368D
   Active Site
   92N, 97C, 351H, 368D
   CDD
   cd02668 (Peptidase_C19L)
2. key conserved lysi...
   1,049K
   key conserved lysine K27
   1,049K
   CDD
   cd01795 (Ubl_USP48)

### GO term prediction

#### Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

#### Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0