Protein

## Lalb_05686

Length
606 amino acids

### Protein family membership

- Voltage-gated potassium channel (IPR028325)
  - Potassium channel, voltage dependent, Kv (IPR003968)
    - Potassium channel, voltage dependent, Kv3 (IPR003974)
      - Potassium channel, voltage dependent, Shaw, invertebrate (IPR015572)

### Homologous superfamilies

1. Homologous superfamily
   10 - 109
   - SKP1/BTB/POZ domain superfamily (IPR011333)
   147 - 303
   - Voltage-dependent channel domain superfamily (IPR027359)

1 100 200 300 400 500 606

### Domains and repeats

1. Domain
   11 - 111
   - BTB/POZ domain (IPR000210)
     - Potassium channel tetramerisation-type BTB domain (IPR003131)
   175 - 415
   - Ion transport domain (IPR005821)

1 100 200 300 400 500 606

### Detailed signature matches

1. IPR011333
   SKP1/BTB/POZ domain superfamily
   1. SSF54695 (POZ domain)
      10 - 109
      SUPERFAMILY
      SSF54695 (POZ domain)
2. IPR027359
   Voltage-dependent channel domain superfamily
   1. G3DSA:1.20.12...
      147 - 303
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
3. IPR028325
   Voltage-gated potassium channel
   1. PTHR11537 (VOLTAGE-...)
      10 - 443
      PANTHER
      PTHR11537 (VOLTAGE-GATED POTASSIUM CHANNEL)
4. IPR003968
   Potassium channel, voltage dependent, Kv
   1. PR01491 (KVCHANNEL)
      53 - 63
      PRINTS
      PR01491 (KVCHANNEL)
      296 - 304
      PRINTS
      PR01491 (KVCHANNEL)
      393 - 404
      PRINTS
      PR01491 (KVCHANNEL)
      320 - 334
      PRINTS
      PR01491 (KVCHANNEL)
5. IPR003974
   Potassium channel, voltage dependent, Kv3
   1. PR01498 (SHAWCHANNEL)
      418 - 432
      PRINTS
      PR01498 (SHAWCHANNEL)
      69 - 84
      PRINTS
      PR01498 (SHAWCHANNEL)
      165 - 177
      PRINTS
      PR01498 (SHAWCHANNEL)
      87 - 108
      PRINTS
      PR01498 (SHAWCHANNEL)
      54 - 67
      PRINTS
      PR01498 (SHAWCHANNEL)
6. IPR015572
   Potassium channel, voltage dependent, Shaw, invertebrate
   1. PTHR11537:SF257 (PO...)
      10 - 443
      PANTHER
      PTHR11537:SF257 (POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW)
7. IPR000210
   BTB/POZ domain
   1. SM00225 (BTB_4)
      11 - 111
      SMART
      SM00225 (BTB_4)
8. IPR003131
   Potassium channel tetramerisation-type BTB domain
   1. PF02214 (BTB_2)
      13 - 103
      Pfam
      PF02214 (BTB_2)
9. IPR005821
   Ion transport domain
   1. PF00520 (Ion_trans)
      175 - 415
      Pfam
      PF00520 (Ion_trans)

no IPR
Unintegrated signatures

1. G3DSA:1.10.28...
   304 - 416
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
2. G3DSA:3.30.71... (P...)
   8 - 121
   GENE3D
   G3DSA:3.30.710.10 (Potassium Channel Kv1.1; Chain A)
3. PR00169 (KCHANNEL)
   291 - 317
   PRINTS
   PR00169 (KCHANNEL)
   53 - 72
   PRINTS
   PR00169 (KCHANNEL)
   258 - 278
   PRINTS
   PR00169 (KCHANNEL)
   232 - 255
   PRINTS
   PR00169 (KCHANNEL)
   353 - 375
   PRINTS
   PR00169 (KCHANNEL)
   320 - 343
   PRINTS
   PR00169 (KCHANNEL)
   382 - 408
   PRINTS
   PR00169 (KCHANNEL)
   168 - 196
   PRINTS
   PR00169 (KCHANNEL)
4. SSF81324 (Voltage-g...)
   173 - 409
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
5. cd18416 (BTB_Shaw-like)
   10 - 121
   CDD
   cd18416 (BTB_Shaw-like)

### Other features

1. mobidb-lite (disord...)
   423 - 521
   MobiDB Lite
   mobidb-lite (disorder_prediction)
2. mobidb-lite (Polar)
   491 - 515
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   441 - 455
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar

### Residue annotation

1. putative tetramer ...
   16N
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   18G
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   19G
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   20I
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   21R
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   22H
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   23E
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   24T
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   25Y
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   28T
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   55F
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   57D
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   58R
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   61G
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   64A
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   68N
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   71R
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   74K
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   76H
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   84P
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   85L
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
   88E
   putative tetramer interface
   16N, 18G, 19G, 20I, 21R, 22H, 23E, 24T, 25Y, 28T, 55F, 57D, 58R, 61G, 64A, 68N, 71R, 74K, 76H, 84P, 85L, 88E
   CDD
   cd18416 (BTB_Shaw-like)
2. Zn binding site cd...
   76H
   Zn binding site
   76H, 82C, 103C, 104C
   CDD
   cd18416 (BTB_Shaw-like)
   82C
   Zn binding site
   76H, 82C, 103C, 104C
   CDD
   cd18416 (BTB_Shaw-like)
   103C
   Zn binding site
   76H, 82C, 103C, 104C
   CDD
   cd18416 (BTB_Shaw-like)
   104C
   Zn binding site
   76H, 82C, 103C, 104C
   CDD
   cd18416 (BTB_Shaw-like)

### GO term prediction

#### Biological Process

GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport

#### Molecular Function

GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding

#### Cellular Component

GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane

Generated with InterProScan 5.45-80.0