Protein

## Lalb_04003

Length
1,613 amino acids

### Protein family membership

- Nuclear receptor coactivator (IPR017426)

### Homologous superfamilies

1. Homologous superfamily
   26 - 124
   - Helix-loop-helix DNA-binding domain superfamily (IPR036638)
2. Homologous superfamily
   124 - 200
   - PAS domain superfamily (IPR035965)
   273 - 378
   - PAS domain superfamily (IPR035965)

1 200 400 600 800 1000 1200 1400 1613

### Domains and repeats

1. Domain
   32 - 93
   - Myc-type, basic helix-loop-helix (bHLH) domain (IPR011598)
   115 - 181
   - PAS domain (IPR000014)
   263 - 331
   - PAS domain (IPR000014)

1 200 400 600 800 1000 1200 1400 1613

### Detailed signature matches

1. IPR036638
   Helix-loop-helix DNA-binding domain superfamily
   1. G3DSA:4.10.28... (HLH)
      42 - 124
      GENE3D
      G3DSA:4.10.280.10 (HLH)
   2. SSF47459 (HLH, heli...)
      26 - 96
      SUPERFAMILY
      SSF47459 (HLH, helix-loop-helix DNA-binding domain)
2. IPR035965
   PAS domain superfamily
   1. SSF55785 (PYP-like ...)
      124 - 200
      SUPERFAMILY
      SSF55785 (PYP-like sensor domain (PAS domain))
      273 - 378
      SUPERFAMILY
      SSF55785 (PYP-like sensor domain (PAS domain))
3. IPR017426
   Nuclear receptor coactivator
   1. PTHR10684 (NUCLEAR ...)
      24 - 1,047
      PANTHER
      PTHR10684 (NUCLEAR RECEPTOR COACTIVATOR)
4. IPR011598
   Myc-type, basic helix-loop-helix (bHLH) domain
   1. PS50888 (BHLH)
      34 - 87
      PROSITE profiles
      PS50888 (BHLH)
   2. cd00083 (HLH)
      32 - 91
      CDD
      cd00083 (HLH)
   3. SM00353 (finulus)
      40 - 93
      SMART
      SM00353 (finulus)
   4. PF00010 (HLH)
      38 - 87
      Pfam
      PF00010 (HLH)
5. IPR000014
   PAS domain
   1. PS50112 (PAS)
      120 - 176
      PROSITE profiles
      PS50112 (PAS)
   2. SM00091 (pas_2)
      115 - 181
      SMART
      SM00091 (pas_2)
      263 - 331
      SMART
      SM00091 (pas_2)
   3. cd00130 (PAS)
      124 - 176
      CDD
      cd00130 (PAS)

no IPR
Unintegrated signatures

1. G3DSA:3.30.45...
   270 - 379
   GENE3D
   G3DSA:3.30.450.20 (G3DSA:3.30.450.20)
   125 - 259
   GENE3D
   G3DSA:3.30.450.20 (G3DSA:3.30.450.20)
2. PF14598 (PAS_11)
   272 - 381
   Pfam
   PF14598 (PAS_11)
3. PTHR10684:SF4 (TAIM...)
   24 - 1,047
   PANTHER
   PTHR10684:SF4 (TAIMAN, ISOFORM G)

### Other features

1. Coil
   1,118 - 1,146
   COILS
   Coil (Coil)
   746 - 766
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   1,202 - 1,419
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   565 - 1,000
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   1,488 - 1,507
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   407 - 444
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   508 - 543
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   1,440 - 1,476
   MobiDB Lite
   mobidb-lite (disorder_prediction)
3. mobidb-lite (Polyam...)
   728 - 779
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   670 - 698
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
4. mobidb-lite (Prolin...)
   1,313 - 1,337
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Proline-rich
5. mobidb-lite (Polar)
   1,202 - 1,241
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   565 - 669
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   780 - 803
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   879 - 997
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   826 - 845
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,370 - 1,419
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,256 - 1,312
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   699 - 727
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,339 - 1,360
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar

### Residue annotation

1. DNA binding region...
   35S
   DNA binding region
   35S, 36Q, 42N, 43E, 44K, 46R, 70K, 73K
   CDD
   cd00083 (HLH)
   36Q
   DNA binding region
   35S, 36Q, 42N, 43E, 44K, 46R, 70K, 73K
   CDD
   cd00083 (HLH)
   42N
   DNA binding region
   35S, 36Q, 42N, 43E, 44K, 46R, 70K, 73K
   CDD
   cd00083 (HLH)
   43E
   DNA binding region
   35S, 36Q, 42N, 43E, 44K, 46R, 70K, 73K
   CDD
   cd00083 (HLH)
   44K
   DNA binding region
   35S, 36Q, 42N, 43E, 44K, 46R, 70K, 73K
   CDD
   cd00083 (HLH)
   46R
   DNA binding region
   35S, 36Q, 42N, 43E, 44K, 46R, 70K, 73K
   CDD
   cd00083 (HLH)
   70K
   DNA binding region
   35S, 36Q, 42N, 43E, 44K, 46R, 70K, 73K
   CDD
   cd00083 (HLH)
   73K
   DNA binding region
   35S, 36Q, 42N, 43E, 44K, 46R, 70K, 73K
   CDD
   cd00083 (HLH)
2. E-box/N-box specif...
   43E
   E-box/N-box specificity site
   43E
   CDD
   cd00083 (HLH)
3. dimerization inter...
   49Q
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   50E
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   53F
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   54I
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   56E
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   57L
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   74C
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   77L
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   81V
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   83Q
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   84I
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   88R
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   90Q
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)
   91E
   dimerization interface
   49Q, 50E, 53F, 54I, 56E, 57L, 74C, 77L, 81V, 83Q, 84I, 88R, 90Q, 91E
   CDD
   cd00083 (HLH)

### GO term prediction

#### Biological Process

GO:0006355 regulation of transcription, DNA-templated

#### Molecular Function

GO:0030374 nuclear receptor transcription coactivator activity
GO:0046983 protein dimerization activity

#### Cellular Component

GO:0005634 nucleus

Generated with InterProScan 5.45-80.0