Protein

## Lalb_10461

Length
530 amino acids

### Protein family membership

- RuvB-like (IPR027238)
  - RuvB-like helicase 2 (IPR037942)

### Homologous superfamilies

1. Homologous superfamily
   111 - 500
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
2. Homologous superfamily
   193 - 317
   - RuvB-like helicase 2, domain II (IPR042487)

1 50 100 150 200 250 300 350 400 450 500 530

### Domains and repeats

1. Domain
   88 - 431
   - TIP49, P-loop domain (IPR010339)
2. Domain
   136 - 428
   - AAA+ ATPase domain (IPR003593)
   437 - 502
   - RuvB-like, AAA-lid domain (IPR041048)

1 50 100 150 200 250 300 350 400 450 500 530

### Detailed signature matches

1. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      111 - 500
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
2. IPR042487
   RuvB-like helicase 2, domain II
   1. G3DSA:2.40.50...
      193 - 317
      GENE3D
      G3DSA:2.40.50.360 (G3DSA:2.40.50.360)
3. IPR027238
   RuvB-like
   1. PTHR11093 (RUVB-REL...)
      73 - 527
      PANTHER
      PTHR11093 (RUVB-RELATED REPTIN AND PONTIN)
4. IPR037942
   RuvB-like helicase 2
   1. PTHR11093:SF2 (RUVB...)
      73 - 527
      PANTHER
      PTHR11093:SF2 (RUVB-LIKE 2)
5. IPR010339
   TIP49, P-loop domain
   1. PF06068 (TIP49)
      88 - 431
      Pfam
      PF06068 (TIP49)
6. IPR003593
   AAA+ ATPase domain
   1. SM00382 (AAA_5)
      136 - 428
      SMART
      SM00382 (AAA_5)
7. IPR041048
   RuvB-like, AAA-lid domain
   1. PF17856 (TIP49_C)
      437 - 502
      Pfam
      PF17856 (TIP49_C)

no IPR
Unintegrated signatures

1. G3DSA:1.10.8.60
   430 - 530
   GENE3D
   G3DSA:1.10.8.60 (G3DSA:1.10.8.60)
2. G3DSA:3.40.50...
   91 - 192
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   318 - 424
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
3. cd00009 (AAA)
   137 - 205
   CDD
   cd00009 (AAA)
   336 - 424
   CDD
   cd00009 (AAA)

### Residue annotation

1. Walker A motif cd0...
   144G
   Walker A motif
   144G, 145Q, 146P, 147G, 148T, 149G, 150K, 151T
   CDD
   cd00009 (AAA)
   145Q
   Walker A motif
   144G, 145Q, 146P, 147G, 148T, 149G, 150K, 151T
   CDD
   cd00009 (AAA)
   146P
   Walker A motif
   144G, 145Q, 146P, 147G, 148T, 149G, 150K, 151T
   CDD
   cd00009 (AAA)
   147G
   Walker A motif
   144G, 145Q, 146P, 147G, 148T, 149G, 150K, 151T
   CDD
   cd00009 (AAA)
   148T
   Walker A motif
   144G, 145Q, 146P, 147G, 148T, 149G, 150K, 151T
   CDD
   cd00009 (AAA)
   149G
   Walker A motif
   144G, 145Q, 146P, 147G, 148T, 149G, 150K, 151T
   CDD
   cd00009 (AAA)
   150K
   Walker A motif
   144G, 145Q, 146P, 147G, 148T, 149G, 150K, 151T
   CDD
   cd00009 (AAA)
   151T
   Walker A motif
   144G, 145Q, 146P, 147G, 148T, 149G, 150K, 151T
   CDD
   cd00009 (AAA)
2. Walker B motif cd0...
   362V
   Walker B motif
   362V, 363L, 364F, 365I, 366D, 367E
   CDD
   cd00009 (AAA)
   363L
   Walker B motif
   362V, 363L, 364F, 365I, 366D, 367E
   CDD
   cd00009 (AAA)
   364F
   Walker B motif
   362V, 363L, 364F, 365I, 366D, 367E
   CDD
   cd00009 (AAA)
   365I
   Walker B motif
   362V, 363L, 364F, 365I, 366D, 367E
   CDD
   cd00009 (AAA)
   366D
   Walker B motif
   362V, 363L, 364F, 365I, 366D, 367E
   CDD
   cd00009 (AAA)
   367E
   Walker B motif
   362V, 363L, 364F, 365I, 366D, 367E
   CDD
   cd00009 (AAA)
3. arginine finger cd...
   420R
   arginine finger
   420R
   CDD
   cd00009 (AAA)

### GO term prediction

#### Biological Process

None predicted.

#### Molecular Function

GO:0003678 DNA helicase activity
GO:0005524 ATP binding
GO:0043139 5'-3' DNA helicase activity

#### Cellular Component

GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0097255 R2TP complex

Generated with InterProScan 5.45-80.0