Protein

## Lalb_01648

Length
526 amino acids

### Protein family membership

- E3 ubiquitin-protein ligase RFWD3 (IPR037381)

### Homologous superfamilies

1. Homologous superfamily
   46 - 138
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
   163 - 523
   - WD40-repeat-containing domain superfamily (IPR036322)
2. Homologous superfamily
   197 - 524
   - WD40/YVTN repeat-like-containing domain superfamily (IPR015943)

1 50 100 150 200 250 300 350 400 450 500 526

### Domains and repeats

1. Domain
   57 - 106
   - Zinc finger, RING-type (IPR001841)
2. Repeat
   247 - 287
   - WD40 repeat (IPR001680)
   290 - 329
   - WD40 repeat (IPR001680)
   485 - 524
   - WD40 repeat (IPR001680)

1 50 100 150 200 250 300 350 400 450 500 526

### Detailed signature matches

1. IPR013083
   Zinc finger, RING/FYVE/PHD-type
   1. G3DSA:3.30.40.10 (Z...)
      46 - 138
      GENE3D
      G3DSA:3.30.40.10 (Zinc/RING finger domain)
2. IPR036322
   WD40-repeat-containing domain superfamily
   1. SSF50978 (WD40 repe...)
      163 - 416
      SUPERFAMILY
      SSF50978 (WD40 repeat-like)
      477 - 523
      SUPERFAMILY
      SSF50978 (WD40 repeat-like)
3. IPR015943
   WD40/YVTN repeat-like-containing domain superfamily
   1. G3DSA:2.130.1...
      197 - 524
      GENE3D
      G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
4. IPR037381
   E3 ubiquitin-protein ligase RFWD3
   1. PTHR16047 (RFWD3 PR...)
      9 - 523
      PANTHER
      PTHR16047 (RFWD3 PROTEIN)
5. IPR001841
   Zinc finger, RING-type
   1. SM00184 (ring_2)
      58 - 105
      SMART
      SM00184 (ring_2)
   2. PF13639 (zf-RING_2)
      57 - 106
      Pfam
      PF13639 (zf-RING_2)
   3. PS50089 (ZF_RING_2)
      58 - 106
      PROSITE profiles
      PS50089 (ZF_RING_2)
6. IPR001680
   WD40 repeat
   1. SM00320 (WD40_4)
      247 - 287
      SMART
      SM00320 (WD40_4)
      485 - 524
      SMART
      SM00320 (WD40_4)
      290 - 329
      SMART
      SM00320 (WD40_4)

no IPR
Unintegrated signatures

1. PTHR16047:SF7 (E3 U...)
   9 - 523
   PANTHER
   PTHR16047:SF7 (E3 UBIQUITIN-PROTEIN LIGASE RFWD3)
2. SSF57850 (RING/U-box)
   46 - 110
   SUPERFAMILY
   SSF57850 (RING/U-box)
3. cd16450 (mRING-C3HG...)
   55 - 106
   CDD
   cd16450 (mRING-C3HGC3_RFWD3)

### Other features

1. Coil
   130 - 178
   COILS
   Coil (Coil)
   25 - 45
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   1 - 48
   MobiDB Lite
   mobidb-lite (disorder_prediction)
3. mobidb-lite (Polyam...)
   33 - 48
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte

### Residue annotation

1. modified RING fing...
   58C
   modified RING finger (C3HGC3-type)
   58C, 61C, 78C, 80H, 83G, 86C, 102C, 105C
   CDD
   cd16450 (mRING-C3HGC3_RFWD3)
   61C
   modified RING finger (C3HGC3-type)
   58C, 61C, 78C, 80H, 83G, 86C, 102C, 105C
   CDD
   cd16450 (mRING-C3HGC3_RFWD3)
   78C
   modified RING finger (C3HGC3-type)
   58C, 61C, 78C, 80H, 83G, 86C, 102C, 105C
   CDD
   cd16450 (mRING-C3HGC3_RFWD3)
   80H
   modified RING finger (C3HGC3-type)
   58C, 61C, 78C, 80H, 83G, 86C, 102C, 105C
   CDD
   cd16450 (mRING-C3HGC3_RFWD3)
   83G
   modified RING finger (C3HGC3-type)
   58C, 61C, 78C, 80H, 83G, 86C, 102C, 105C
   CDD
   cd16450 (mRING-C3HGC3_RFWD3)
   86C
   modified RING finger (C3HGC3-type)
   58C, 61C, 78C, 80H, 83G, 86C, 102C, 105C
   CDD
   cd16450 (mRING-C3HGC3_RFWD3)
   102C
   modified RING finger (C3HGC3-type)
   58C, 61C, 78C, 80H, 83G, 86C, 102C, 105C
   CDD
   cd16450 (mRING-C3HGC3_RFWD3)
   105C
   modified RING finger (C3HGC3-type)
   58C, 61C, 78C, 80H, 83G, 86C, 102C, 105C
   CDD
   cd16450 (mRING-C3HGC3_RFWD3)

### GO term prediction

#### Biological Process

GO:0016567 protein ubiquitination
GO:0036297 interstrand cross-link repair

#### Molecular Function

GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding

#### Cellular Component

GO:0005634 nucleus

Generated with InterProScan 5.45-80.0