Protein

## Lalb_05651

Length
2,182 amino acids

### Protein family membership

None predicted.

### Homologous superfamilies

1. Homologous superfamily
   154 - 410
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   487 - 748
   - P-loop containing nucleoside triphosphate hydrolase (IPR027417)
   1,699 - 1,872
   - Dynein heavy chain AAA lid domain superfamily (IPR042219)
   2,042 - 2,182
   - Dynein heavy chain, C-terminal domain, barrel region (IPR043160)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2182

### Domains and repeats

1. Domain
   2 - 119
   - Dynein heavy chain, AAA 5 extension domain (IPR041466)
   337 - 426
   - Dynein heavy chain 3, AAA+ lid domain (IPR041589)
   486 - 745
   - Dynein heavy chain, AAA module D4 (IPR024317)
   758 - 1,091
   - Dynein heavy chain, coiled coil stalk (IPR024743)
   1,119 - 1,338
   - Dynein heavy chain, ATP-binding dynein motor region (IPR035706)
   1,585 - 1,697
   - Dynein heavy chain region D6 P-loop domain (IPR004273)
   1,711 - 1,875
   - Dynein heavy chain AAA lid domain (IPR041658)
   1,882 - 2,179
   - Dynein heavy chain, C-terminal domain (IPR041228)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2182

### Detailed signature matches

1. IPR027417
   P-loop containing nucleoside triphosphate hydrolase
   1. SSF52540 (P-loop co...)
      634 - 748
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      487 - 602
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
      154 - 410
      SUPERFAMILY
      SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
2. IPR042219
   Dynein heavy chain AAA lid domain superfamily
   1. G3DSA:1.10.8.720
      1,699 - 1,872
      GENE3D
      G3DSA:1.10.8.720 (G3DSA:1.10.8.720)
3. IPR043160
   Dynein heavy chain, C-terminal domain, barrel region
   1. G3DSA:3.10.49...
      2,042 - 2,182
      GENE3D
      G3DSA:3.10.490.20 (G3DSA:3.10.490.20)
4. IPR041466
   Dynein heavy chain, AAA 5 extension domain
   1. PF17852 (Dynein_AAA...)
      2 - 119
      Pfam
      PF17852 (Dynein_AAA_lid)
5. IPR041589
   Dynein heavy chain 3, AAA+ lid domain
   1. PF17857 (AAA_lid_1)
      337 - 426
      Pfam
      PF17857 (AAA_lid_1)
6. IPR024317
   Dynein heavy chain, AAA module D4
   1. PF12780 (AAA_8)
      486 - 745
      Pfam
      PF12780 (AAA_8)
7. IPR024743
   Dynein heavy chain, coiled coil stalk
   1. PF12777 (MT)
      758 - 1,091
      Pfam
      PF12777 (MT)
8. IPR035706
   Dynein heavy chain, ATP-binding dynein motor region
   1. PF12781 (AAA_9)
      1,119 - 1,338
      Pfam
      PF12781 (AAA_9)
9. IPR004273
   Dynein heavy chain region D6 P-loop domain
   1. PF03028 (Dynein_heavy)
      1,585 - 1,697
      Pfam
      PF03028 (Dynein_heavy)
10. IPR041658
    Dynein heavy chain AAA lid domain
    1. PF18198 (AAA_lid_11)
       1,711 - 1,875
       Pfam
       PF18198 (AAA_lid_11)
11. IPR041228
    Dynein heavy chain, C-terminal domain
    1. PF18199 (Dynein_C)
       1,882 - 2,179
       Pfam
       PF18199 (Dynein_C)

no IPR
Unintegrated signatures

1. G3DSA:1.10.47...
   17 - 137
   GENE3D
   G3DSA:1.10.472.130 (G3DSA:1.10.472.130)
2. G3DSA:1.10.8....
   1,359 - 1,449
   GENE3D
   G3DSA:1.10.8.1220 (G3DSA:1.10.8.1220)
3. G3DSA:1.20.12...
   1,884 - 2,040
   GENE3D
   G3DSA:1.20.1270.280 (G3DSA:1.20.1270.280)
4. G3DSA:1.20.92...
   732 - 1,070
   GENE3D
   G3DSA:1.20.920.20 (G3DSA:1.20.920.20)
5. G3DSA:1.20.92...
   307 - 507
   GENE3D
   G3DSA:1.20.920.30 (G3DSA:1.20.920.30)
6. G3DSA:3.40.50...
   1,111 - 1,278
   GENE3D
   G3DSA:3.40.50.11510 (G3DSA:3.40.50.11510)
7. G3DSA:3.40.50...
   508 - 671
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   138 - 306
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
   1,574 - 1,698
   GENE3D
   G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
8. PF12775 (AAA_7)
   126 - 306
   Pfam
   PF12775 (AAA_7)
9. PTHR45703 (FAMILY N...)
   3 - 2,182
   PANTHER
   PTHR45703 (FAMILY NOT NAMED)
10. PTHR45703:SF3
    3 - 2,182
    PANTHER
    PTHR45703:SF3 (PTHR45703:SF3)
11. cd00009 (AAA)
    158 - 234
    CDD
    cd00009 (AAA)

### Other features

1. Coil
   1,282 - 1,302
   COILS
   Coil (Coil)
   1,950 - 1,970
   COILS
   Coil (Coil)
   813 - 843
   COILS
   Coil (Coil)
   1,036 - 1,056
   COILS
   Coil (Coil)
   970 - 1,028
   COILS
   Coil (Coil)

### Residue annotation

1. Walker A motif cd0...
   164G
   Walker A motif
   164G, 165E, 166T, 167G, 168T, 169S, 170K, 171T
   CDD
   cd00009 (AAA)
   165E
   Walker A motif
   164G, 165E, 166T, 167G, 168T, 169S, 170K, 171T
   CDD
   cd00009 (AAA)
   166T
   Walker A motif
   164G, 165E, 166T, 167G, 168T, 169S, 170K, 171T
   CDD
   cd00009 (AAA)
   167G
   Walker A motif
   164G, 165E, 166T, 167G, 168T, 169S, 170K, 171T
   CDD
   cd00009 (AAA)
   168T
   Walker A motif
   164G, 165E, 166T, 167G, 168T, 169S, 170K, 171T
   CDD
   cd00009 (AAA)
   169S
   Walker A motif
   164G, 165E, 166T, 167G, 168T, 169S, 170K, 171T
   CDD
   cd00009 (AAA)
   170K
   Walker A motif
   164G, 165E, 166T, 167G, 168T, 169S, 170K, 171T
   CDD
   cd00009 (AAA)
   171T
   Walker A motif
   164G, 165E, 166T, 167G, 168T, 169S, 170K, 171T
   CDD
   cd00009 (AAA)
2. ATP binding site c...
   165E
   ATP binding site
   165E, 166T, 167G, 168T, 169S, 170K, 171T, 172A, 231D
   CDD
   cd00009 (AAA)
   166T
   ATP binding site
   165E, 166T, 167G, 168T, 169S, 170K, 171T, 172A, 231D
   CDD
   cd00009 (AAA)
   167G
   ATP binding site
   165E, 166T, 167G, 168T, 169S, 170K, 171T, 172A, 231D
   CDD
   cd00009 (AAA)
   168T
   ATP binding site
   165E, 166T, 167G, 168T, 169S, 170K, 171T, 172A, 231D
   CDD
   cd00009 (AAA)
   169S
   ATP binding site
   165E, 166T, 167G, 168T, 169S, 170K, 171T, 172A, 231D
   CDD
   cd00009 (AAA)
   170K
   ATP binding site
   165E, 166T, 167G, 168T, 169S, 170K, 171T, 172A, 231D
   CDD
   cd00009 (AAA)
   171T
   ATP binding site
   165E, 166T, 167G, 168T, 169S, 170K, 171T, 172A, 231D
   CDD
   cd00009 (AAA)
   172A
   ATP binding site
   165E, 166T, 167G, 168T, 169S, 170K, 171T, 172A, 231D
   CDD
   cd00009 (AAA)
   231D
   ATP binding site
   165E, 166T, 167G, 168T, 169S, 170K, 171T, 172A, 231D
   CDD
   cd00009 (AAA)
3. Walker B motif cd0...
   227L
   Walker B motif
   227L, 228V, 229F, 230I, 231D, 232D
   CDD
   cd00009 (AAA)
   228V
   Walker B motif
   227L, 228V, 229F, 230I, 231D, 232D
   CDD
   cd00009 (AAA)
   229F
   Walker B motif
   227L, 228V, 229F, 230I, 231D, 232D
   CDD
   cd00009 (AAA)
   230I
   Walker B motif
   227L, 228V, 229F, 230I, 231D, 232D
   CDD
   cd00009 (AAA)
   231D
   Walker B motif
   227L, 228V, 229F, 230I, 231D, 232D
   CDD
   cd00009 (AAA)
   232D
   Walker B motif
   227L, 228V, 229F, 230I, 231D, 232D
   CDD
   cd00009 (AAA)

### GO term prediction

#### Biological Process

GO:0007018 microtubule-based movement

#### Molecular Function

GO:0003777 microtubule motor activity

#### Cellular Component

GO:0030286 dynein complex

Generated with InterProScan 5.45-80.0