Protein

## Lalb_10715

Length
2,503 amino acids

### Protein family membership

None predicted.

### Homologous superfamilies

1. Homologous superfamily
   86 - 152
   - Winged helix-like DNA-binding domain superfamily (IPR036388)
   188 - 310
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
   1,136 - 1,206
   - Winged helix-like DNA-binding domain superfamily (IPR036388)
2. Homologous superfamily
   89 - 159
   - Winged helix DNA-binding domain superfamily (IPR036390)
   250 - 302
   - Zinc finger, FYVE/PHD-type (IPR011011)
   959 - 1,226
   - Acyl-CoA N-acyltransferase (IPR016181)

1 500 1000 1500 2000 2503

### Domains and repeats

1. Domain
   87 - 159
   - Linker histone H1/H5, domain H15 (IPR005818)
   959 - 1,012
   - MYST, zinc finger domain (IPR040706)
2. Domain
   189 - 248
   - Zinc finger, PHD-type (IPR001965)
   248 - 299
   - Zinc finger, PHD-type (IPR001965)
     - Zinc finger, PHD-finger (IPR019787)
   956 - 1,228
   - Histone acetyltransferase domain, MYST-type (IPR002717)

1 500 1000 1500 2000 2503

### Detailed signature matches

1. IPR036388
   Winged helix-like DNA-binding domain superfamily
   1. G3DSA:1.10.10.10 ("...)
      1,136 - 1,206
      GENE3D
      G3DSA:1.10.10.10 (""winged helix"" repressor DNA binding domain)
      86 - 152
      GENE3D
      G3DSA:1.10.10.10 (""winged helix"" repressor DNA binding domain)
2. IPR036390
   Winged helix DNA-binding domain superfamily
   1. SSF46785 ("Winged h...)
      89 - 159
      SUPERFAMILY
      SSF46785 ("Winged helix" DNA-binding domain)
3. IPR013083
   Zinc finger, RING/FYVE/PHD-type
   1. G3DSA:3.30.40.10 (Z...)
      188 - 310
      GENE3D
      G3DSA:3.30.40.10 (Zinc/RING finger domain)
4. IPR011011
   Zinc finger, FYVE/PHD-type
   1. SSF57903 (FYVE/PHD ...)
      250 - 302
      SUPERFAMILY
      SSF57903 (FYVE/PHD zinc finger)
5. IPR016181
   Acyl-CoA N-acyltransferase
   1. SSF55729 (Acyl-CoA ...)
      959 - 1,226
      SUPERFAMILY
      SSF55729 (Acyl-CoA N-acyltransferases (Nat))
6. IPR005818
   Linker histone H1/H5, domain H15
   1. PF00538 (Linker_his...)
      93 - 150
      Pfam
      PF00538 (Linker_histone)
   2. SM00526 (h15plus2)
      87 - 153
      SMART
      SM00526 (h15plus2)
   3. PS51504 (H15)
      87 - 159
      PROSITE profiles
      PS51504 (H15)
7. IPR001965
   Zinc finger, PHD-type
   1. SM00249 (PHD_3)
      189 - 248
      SMART
      SM00249 (PHD_3)
      250 - 297
      SMART
      SM00249 (PHD_3)
8. IPR019787
   Zinc finger, PHD-finger
   1. PF00628 (PHD)
      251 - 298
      Pfam
      PF00628 (PHD)
   2. PS50016 (ZF_PHD_2)
      248 - 299
      PROSITE profiles
      PS50016 (ZF_PHD_2)
9. IPR002717
   Histone acetyltransferase domain, MYST-type
   1. PS51726 (MYST_HAT)
      956 - 1,228
      PROSITE profiles
      PS51726 (MYST_HAT)
   2. PF01853 (MOZ_SAS)
      1,017 - 1,184
      Pfam
      PF01853 (MOZ_SAS)
10. IPR040706
    MYST, zinc finger domain
    1. PF17772 (zf-MYST)
       959 - 1,012
       Pfam
       PF17772 (zf-MYST)
11. IPR019786
    Zinc finger, PHD-type, conserved site
    1. PS01359 (ZF_PHD_1)
       216 - 296
       PROSITE patterns
       PS01359 (ZF_PHD_1)

no IPR
Unintegrated signatures

1. G3DSA:3.30.60.60
   951 - 1,013
   GENE3D
   G3DSA:3.30.60.60 (G3DSA:3.30.60.60)
2. G3DSA:3.40.63...
   1,207 - 1,228
   GENE3D
   G3DSA:3.40.630.30 (G3DSA:3.40.630.30)
   1,015 - 1,135
   GENE3D
   G3DSA:3.40.630.30 (G3DSA:3.40.630.30)
3. PTHR10615 (HISTONE ...)
   13 - 297
   PANTHER
   PTHR10615 (HISTONE ACETYLTRANSFERASE)
   954 - 1,698
   PANTHER
   PTHR10615 (HISTONE ACETYLTRANSFERASE)
4. PTHR10615:SF73 (HIS...)
   13 - 297
   PANTHER
   PTHR10615:SF73 (HISTONE ACETYLTRANSFERASE KAT6B)
   954 - 1,698
   PANTHER
   PTHR10615:SF73 (HISTONE ACETYLTRANSFERASE KAT6B)
5. SSF81995 (beta-sand...)
   445 - 497
   SUPERFAMILY
   SSF81995 (beta-sandwich domain of Sec23/24)
6. cd15489 (PHD_SF)
   250 - 296
   CDD
   cd15489 (PHD_SF)

### Other features

1. Coil
   447 - 475
   COILS
   Coil (Coil)
   1,464 - 1,494
   COILS
   Coil (Coil)
   1,557 - 1,577
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   2,358 - 2,381
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   421 - 543
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   766 - 906
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   930 - 956
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   1,235 - 2,222
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   671 - 742
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   304 - 406
   MobiDB Lite
   mobidb-lite (disorder_prediction)
3. mobidb-lite (Polyam...)
   1,304 - 1,358
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   517 - 531
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   1,441 - 1,516
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   1,797 - 1,839
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   325 - 341
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   1,556 - 1,601
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   772 - 788
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   1,741 - 1,784
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
4. mobidb-lite (Prolin...)
   2,024 - 2,047
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Proline-rich
   1,612 - 1,626
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Proline-rich
5. mobidb-lite (Polar)
   793 - 810
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,954 - 1,977
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,286 - 1,303
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,928 - 1,944
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,235 - 1,255
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,848 - 1,921
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,703 - 1,717
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,517 - 1,534
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   858 - 893
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   433 - 510
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,378 - 1,412
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   2,070 - 2,222
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   933 - 950
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   821 - 851
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
6. mobidb-lite (Positi...)
   1,269 - 1,285
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Positive Polyelectrolyte

### Residue annotation

1. histone H3 binding...
   250T
   histone H3 binding site
   250T, 264L, 265V, 266K, 267C, 271V, 291W
   CDD
   cd15489 (PHD_SF)
   264L
   histone H3 binding site
   250T, 264L, 265V, 266K, 267C, 271V, 291W
   CDD
   cd15489 (PHD_SF)
   265V
   histone H3 binding site
   250T, 264L, 265V, 266K, 267C, 271V, 291W
   CDD
   cd15489 (PHD_SF)
   266K
   histone H3 binding site
   250T, 264L, 265V, 266K, 267C, 271V, 291W
   CDD
   cd15489 (PHD_SF)
   267C
   histone H3 binding site
   250T, 264L, 265V, 266K, 267C, 271V, 291W
   CDD
   cd15489 (PHD_SF)
   271V
   histone H3 binding site
   250T, 264L, 265V, 266K, 267C, 271V, 291W
   CDD
   cd15489 (PHD_SF)
   291W
   histone H3 binding site
   250T, 264L, 265V, 266K, 267C, 271V, 291W
   CDD
   cd15489 (PHD_SF)
2. Zn binding site cd...
   251C
   Zn binding site
   251C, 254C, 267C, 270C, 275H, 278C, 293C, 296C
   CDD
   cd15489 (PHD_SF)
   254C
   Zn binding site
   251C, 254C, 267C, 270C, 275H, 278C, 293C, 296C
   CDD
   cd15489 (PHD_SF)
   267C
   Zn binding site
   251C, 254C, 267C, 270C, 275H, 278C, 293C, 296C
   CDD
   cd15489 (PHD_SF)
   270C
   Zn binding site
   251C, 254C, 267C, 270C, 275H, 278C, 293C, 296C
   CDD
   cd15489 (PHD_SF)
   275H
   Zn binding site
   251C, 254C, 267C, 270C, 275H, 278C, 293C, 296C
   CDD
   cd15489 (PHD_SF)
   278C
   Zn binding site
   251C, 254C, 267C, 270C, 275H, 278C, 293C, 296C
   CDD
   cd15489 (PHD_SF)
   293C
   Zn binding site
   251C, 254C, 267C, 270C, 275H, 278C, 293C, 296C
   CDD
   cd15489 (PHD_SF)
   296C
   Zn binding site
   251C, 254C, 267C, 270C, 275H, 278C, 293C, 296C
   CDD
   cd15489 (PHD_SF)

### GO term prediction

#### Biological Process

GO:0006334 nucleosome assembly
GO:0006355 regulation of transcription, DNA-templated
GO:0016573 histone acetylation

#### Molecular Function

GO:0003677 DNA binding
GO:0004402 histone acetyltransferase activity

#### Cellular Component

GO:0000786 nucleosome
GO:0042025 host cell nucleus

Generated with InterProScan 5.45-80.0