Protein

## Lalb_11223

Length
1,165 amino acids

### Protein family membership

- P-type ATPase (IPR001757)
  - P-type ATPase subfamily IIC, subunit alpha (IPR005775)

### Homologous superfamilies

1. Homologous superfamily
   78 - 877
   - P-type ATPase, transmembrane domain superfamily (IPR023298)
   881 - 941
   - P-type ATPase, transmembrane domain superfamily (IPR023298)
   972 - 1,155
   - P-type ATPase, transmembrane domain superfamily (IPR023298)
2. Homologous superfamily
   203 - 309
   - P-type ATPase, A domain superfamily (IPR008250)
   420 - 632
   - P-type ATPase, cytoplasmic domain N (IPR023299)
3. Homologous superfamily
   399 - 796
   - HAD-like superfamily (IPR036412)
4. Homologous superfamily
   408 - 792
   - HAD superfamily (IPR023214)

1 200 400 600 800 1000 1165

### Domains and repeats

1. Domain
   79 - 153
   - Cation-transporting P-type ATPase, N-terminal (IPR004014)
   836 - 877
   - Cation-transporting P-type ATPase, C-terminal (IPR006068)
   881 - 940
   - Cation-transporting P-type ATPase, C-terminal (IPR006068)
   972 - 1,149
   - Cation-transporting P-type ATPase, C-terminal (IPR006068)

1 200 400 600 800 1000 1165

### Detailed signature matches

1. IPR023298
   P-type ATPase, transmembrane domain superfamily
   1. SSF81665 (Calcium A...)
      972 - 1,155
      SUPERFAMILY
      SSF81665 (Calcium ATPase, transmembrane domain M)
      802 - 877
      SUPERFAMILY
      SSF81665 (Calcium ATPase, transmembrane domain M)
      312 - 405
      SUPERFAMILY
      SSF81665 (Calcium ATPase, transmembrane domain M)
      78 - 204
      SUPERFAMILY
      SSF81665 (Calcium ATPase, transmembrane domain M)
      881 - 941
      SUPERFAMILY
      SSF81665 (Calcium ATPase, transmembrane domain M)
2. IPR008250
   P-type ATPase, A domain superfamily
   1. SSF81653 (Calcium A...)
      203 - 309
      SUPERFAMILY
      SSF81653 (Calcium ATPase, transduction domain A)
3. IPR036412
   HAD-like superfamily
   1. SSF56784 (HAD-like)
      727 - 796
      SUPERFAMILY
      SSF56784 (HAD-like)
      399 - 423
      SUPERFAMILY
      SSF56784 (HAD-like)
      622 - 680
      SUPERFAMILY
      SSF56784 (HAD-like)
4. IPR023214
   HAD superfamily
   1. G3DSA:3.40.50...
      632 - 792
      GENE3D
      G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
      408 - 420
      GENE3D
      G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
5. IPR023299
   P-type ATPase, cytoplasmic domain N
   1. SSF81660 (Metal cat...)
      420 - 632
      SUPERFAMILY
      SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
   2. G3DSA:3.40.11...
      421 - 631
      GENE3D
      G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
6. IPR001757
   P-type ATPase
   1. TIGR01494
      726 - 842
      TIGRFAMs
      TIGR01494 (TIGR01494)
      173 - 441
      TIGRFAMs
      TIGR01494 (TIGR01494)
7. IPR005775
   P-type ATPase subfamily IIC, subunit alpha
   1. cd02608 (P-type_ATP...)
      99 - 1,162
      CDD
      cd02608 (P-type_ATPase_Na-K_like)
   2. TIGR01106
      65 - 882
      TIGRFAMs
      TIGR01106 (TIGR01106)
8. IPR004014
   Cation-transporting P-type ATPase, N-terminal
   1. PF00690 (Cation_ATP...)
      81 - 148
      Pfam
      PF00690 (Cation_ATPase_N)
   2. SM00831 (Cation_ATP...)
      79 - 153
      SMART
      SM00831 (Cation_ATPase_N_a_2)
9. IPR006068
   Cation-transporting P-type ATPase, C-terminal
   1. PF00689 (Cation_ATP...)
      836 - 877
      Pfam
      PF00689 (Cation_ATPase_C)
      881 - 940
      Pfam
      PF00689 (Cation_ATPase_C)
      972 - 1,149
      Pfam
      PF00689 (Cation_ATPase_C)
10. IPR018303
    P-type ATPase, phosphorylation site
    1. PS00154 (ATPASE_E1_E2)
       413 - 419
       PROSITE patterns
       PS00154 (ATPASE_E1_E2)

no IPR
Unintegrated signatures

1. G3DSA:1.20.11...
   968 - 1,165
   GENE3D
   G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
   131 - 184
   GENE3D
   G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
   793 - 880
   GENE3D
   G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
   314 - 407
   GENE3D
   G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
   881 - 956
   GENE3D
   G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
2. G3DSA:2.70.15...
   78 - 114
   GENE3D
   G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
   194 - 313
   GENE3D
   G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
3. PF00122 (E1-E2_ATPase)
   201 - 391
   Pfam
   PF00122 (E1-E2_ATPase)
4. PF13246 (Cation_ATPase)
   463 - 557
   Pfam
   PF13246 (Cation_ATPase)
5. PR00119 (CATATPASE)
   646 - 656
   PRINTS
   PR00119 (CATATPASE)
   776 - 788
   PRINTS
   PR00119 (CATATPASE)
   411 - 425
   PRINTS
   PR00119 (CATATPASE)
   624 - 635
   PRINTS
   PR00119 (CATATPASE)
   251 - 265
   PRINTS
   PR00119 (CATATPASE)
   752 - 771
   PRINTS
   PR00119 (CATATPASE)
6. PR00121 (NAKATPASE)
   404 - 425
   PRINTS
   PR00121 (NAKATPASE)
   167 - 187
   PRINTS
   PR00121 (NAKATPASE)
   824 - 845
   PRINTS
   PR00121 (NAKATPASE)
   331 - 353
   PRINTS
   PR00121 (NAKATPASE)
   140 - 154
   PRINTS
   PR00121 (NAKATPASE)
   542 - 560
   PRINTS
   PR00121 (NAKATPASE)
7. PTHR43294 (FAMILY N...)
   880 - 915
   PANTHER
   PTHR43294 (FAMILY NOT NAMED)
   972 - 1,165
   PANTHER
   PTHR43294 (FAMILY NOT NAMED)
   59 - 882
   PANTHER
   PTHR43294 (FAMILY NOT NAMED)
8. PTHR43294:SF9 (SODI...)
   59 - 882
   PANTHER
   PTHR43294:SF9 (SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1)
   880 - 915
   PANTHER
   PTHR43294:SF9 (SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1)
   972 - 1,165
   PANTHER
   PTHR43294:SF9 (SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1)
9. SFLDF00027 (p-type_...)
   392 - 804
   SFLD
   SFLDF00027 (p-type_atpase)
10. SFLDS00003 (Haloaci...)
    392 - 804
    SFLD
    SFLDS00003 (Haloacid_Dehalogenase)

### Residue annotation

1. K binding site cd0...
   366V
   K binding site
   366V, 369V, 371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   369V
   K binding site
   366V, 369V, 371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   371E
   K binding site
   366V, 369V, 371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   820N
   K binding site
   366V, 369V, 371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   823E
   K binding site
   366V, 369V, 371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   848D
   K binding site
   366V, 369V, 371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
2. Na binding site cd...
   371E
   Na binding site
   371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   820N
   Na binding site
   371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   823E
   Na binding site
   371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   848D
   Na binding site
   371E, 820N, 823E, 848D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
3. phosphorylation si...
   413D
   phosphorylation site
   413D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
4. SFLDF00027
   413D
   nucleophile: attacks gamma phosphate moiety of ATP to form covalent intermediate, Mg2+ ligand
   413D
   SFLD
   SFLDF00027 (p-type_atpase)
5. P-type ATPase sign...
   413D
   P-type ATPase signature motif
   413D, 414K, 415T, 416G, 417T, 418L, 419T
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   414K
   P-type ATPase signature motif
   413D, 414K, 415T, 416G, 417T, 418L, 419T
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   415T
   P-type ATPase signature motif
   413D, 414K, 415T, 416G, 417T, 418L, 419T
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   416G
   P-type ATPase signature motif
   413D, 414K, 415T, 416G, 417T, 418L, 419T
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   417T
   P-type ATPase signature motif
   413D, 414K, 415T, 416G, 417T, 418L, 419T
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   418L
   P-type ATPase signature motif
   413D, 414K, 415T, 416G, 417T, 418L, 419T
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   419T
   P-type ATPase signature motif
   413D, 414K, 415T, 416G, 417T, 418L, 419T
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
6. ATP-binding site c...
   413D
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   414K
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   415T
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   487D
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   490E
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   518P
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   519F
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   521S
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   524K
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   526Q
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   545K
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   546G
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   547A
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   588R
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   589V
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   590L
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   654T
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   655G
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   656D
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   729R
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   732P
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   735K
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   754D
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   755G
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   756V
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   757N
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
   758D
   ATP-binding site
   413D, 414K, 415T, 487D, 490E, 518P, 519F, 521S, 524K, 526Q, 545K, 546G, 547A, 588R, 589V, 590L, 654T, 655G, 656D, 729R, 732P, 735K, 754D, 755G, 756V, 757N, 758D
   CDD
   cd02608 (P-type_ATPase_Na-K_like)
7. SFLDF00027
   414K
   probable role in phosphate transfer from ATP
   414K
   SFLD
   SFLDF00027 (p-type_atpase)
8. SFLDF00027
   415T
   conserved in all p-type atpases
   415T, 416G, 417T
   SFLD
   SFLDF00027 (p-type_atpase)
   416G
   conserved in all p-type atpases
   415T, 416G, 417T
   SFLD
   SFLDF00027 (p-type_atpase)
   417T
   conserved in all p-type atpases
   415T, 416G, 417T
   SFLD
   SFLDF00027 (p-type_atpase)
9. SFLDF00027
   654T
   coordinates with phosphate oxygen from ATP
   654T
   SFLD
   SFLDF00027 (p-type_atpase)
10. SFLDF00027
    735K
    stabilizes transition state of phosphoryl transfer by contacting beta & gamma phosphate oxygens of ATP
    735K
    SFLD
    SFLDF00027 (p-type_atpase)
11. SFLDF00027
    754D
    Mg2+ ligand
    754D, 758D
    SFLD
    SFLDF00027 (p-type_atpase)
    758D
    Mg2+ ligand
    754D, 758D
    SFLD
    SFLDF00027 (p-type_atpase)
12. Na binding site cd...
    815Y
    Na binding site
    815Y, 819S, 852D, 1,072Q
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    819S
    Na binding site
    815Y, 819S, 852D, 1,072Q
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    852D
    Na binding site
    815Y, 819S, 852D, 1,072Q
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    1,072Q
    Na binding site
    815Y, 819S, 852D, 1,072Q
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
13. Na binding site cd...
    819S
    Na binding site
    819S, 820N, 823E, 848D
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    820N
    Na binding site
    819S, 820N, 823E, 848D
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    823E
    Na binding site
    819S, 820N, 823E, 848D
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    848D
    Na binding site
    819S, 820N, 823E, 848D
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
14. K binding site cd0...
    819S
    K binding site
    819S, 820N, 823E, 848D, 852D
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    820N
    K binding site
    819S, 820N, 823E, 848D, 852D
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    823E
    K binding site
    819S, 820N, 823E, 848D, 852D
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    848D
    K binding site
    819S, 820N, 823E, 848D, 852D
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
    852D
    K binding site
    819S, 820N, 823E, 848D, 852D
    CDD
    cd02608 (P-type_ATPase_Na-K_like)
15. phosphorylation si...
    1,085S
    phosphorylation site
    1,085S
    CDD
    cd02608 (P-type_ATPase_Na-K_like)

### GO term prediction

#### Biological Process

GO:0006813 potassium ion transport

#### Molecular Function

GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0008556 potassium transmembrane transporter activity, phosphorylative mechanism

#### Cellular Component

GO:0016021 integral component of membrane

Generated with InterProScan 5.45-80.0