Protein

## Lalb_03304

Length
828 amino acids

### Protein family membership

- Ubiquitin binding protein, Hrs/VPS27 (IPR017073)

### Homologous superfamilies

1. Homologous superfamily
   1 - 154
   - ENTH/VHS (IPR008942)
   155 - 224
   - Zinc finger, RING/FYVE/PHD-type (IPR013083)
2. Homologous superfamily
   162 - 223
   - Zinc finger, FYVE/PHD-type (IPR011011)

1 100 200 300 400 500 600 700 828

### Domains and repeats

1. Domain
   4 - 143
   - VHS domain (IPR002014)
   155 - 221
   - FYVE zinc finger (IPR000306)
   379 - 473
   - Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain (IPR024641)
2. Domain
   160 - 220
   - Zinc finger, FYVE-related (IPR017455)

1 100 200 300 400 500 600 700 828

### Detailed signature matches

1. IPR008942
   ENTH/VHS
   1. SSF48464 (ENTH/VHS ...)
      3 - 143
      SUPERFAMILY
      SSF48464 (ENTH/VHS domain)
   2. G3DSA:1.25.40.90
      1 - 154
      GENE3D
      G3DSA:1.25.40.90 (G3DSA:1.25.40.90)
2. IPR013083
   Zinc finger, RING/FYVE/PHD-type
   1. G3DSA:3.30.40.10 (Z...)
      155 - 224
      GENE3D
      G3DSA:3.30.40.10 (Zinc/RING finger domain)
3. IPR011011
   Zinc finger, FYVE/PHD-type
   1. SSF57903 (FYVE/PHD ...)
      162 - 223
      SUPERFAMILY
      SSF57903 (FYVE/PHD zinc finger)
4. IPR017073
   Ubiquitin binding protein, Hrs/VPS27
   1. PIRSF036956 (Hrs_Vps27)
      689 - 826
      PIRSF
      PIRSF036956 (Hrs_Vps27)
      1 - 715
      PIRSF
      PIRSF036956 (Hrs_Vps27)
5. IPR002014
   VHS domain
   1. PS50179 (VHS)
      15 - 143
      PROSITE profiles
      PS50179 (VHS)
   2. PF00790 (VHS)
      4 - 139
      Pfam
      PF00790 (VHS)
   3. SM00288 (VHS_2)
      8 - 139
      SMART
      SM00288 (VHS_2)
6. IPR000306
   FYVE zinc finger
   1. PF01363 (FYVE)
      163 - 220
      Pfam
      PF01363 (FYVE)
   2. SM00064 (fyve_4)
      155 - 221
      SMART
      SM00064 (fyve_4)
7. IPR017455
   Zinc finger, FYVE-related
   1. PS50178 (ZF_FYVE)
      160 - 220
      PROSITE profiles
      PS50178 (ZF_FYVE)
8. IPR024641
   Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain
   1. PF12210 (Hrs_helical)
      379 - 473
      Pfam
      PF12210 (Hrs_helical)
9. IPR003903
   Ubiquitin interacting motif
   1. PS50330 (UIM)
      257 - 276
      PROSITE profiles
      PS50330 (UIM)

no IPR
Unintegrated signatures

1. PTHR46275 (FAMILY N...)
   1 - 828
   PANTHER
   PTHR46275 (FAMILY NOT NAMED)
2. cd03569 (VHS_Hrs)
   6 - 143
   CDD
   cd03569 (VHS_Hrs)
3. cd06503 (ATP-synt_Fo_b)
   443 - 511
   CDD
   cd06503 (ATP-synt_Fo_b)
4. cd15720 (FYVE_Hrs)
   160 - 218
   CDD
   cd15720 (FYVE_Hrs)

### Other features

1. Coil
   442 - 525
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   598 - 810
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   275 - 319
   MobiDB Lite
   mobidb-lite (disorder_prediction)
3. mobidb-lite (Prolin...)
   647 - 700
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Proline-rich
   722 - 736
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Proline-rich
4. mobidb-lite (Polar)
   286 - 301
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   737 - 775
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   626 - 646
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   789 - 810
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar

### Residue annotation

1. FYVE domain interf...
   25W
   FYVE domain interface
   25W, 26V, 29L, 33D, 73K, 74N
   CDD
   cd03569 (VHS_Hrs)
   26V
   FYVE domain interface
   25W, 26V, 29L, 33D, 73K, 74N
   CDD
   cd03569 (VHS_Hrs)
   29L
   FYVE domain interface
   25W, 26V, 29L, 33D, 73K, 74N
   CDD
   cd03569 (VHS_Hrs)
   33D
   FYVE domain interface
   25W, 26V, 29L, 33D, 73K, 74N
   CDD
   cd03569 (VHS_Hrs)
   73K
   FYVE domain interface
   25W, 26V, 29L, 33D, 73K, 74N
   CDD
   cd03569 (VHS_Hrs)
   74N
   FYVE domain interface
   25W, 26V, 29L, 33D, 73K, 74N
   CDD
   cd03569 (VHS_Hrs)
2. putative phosphati...
   160W
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   162D
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   178R
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   179K
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   180H
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   181H
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   182C
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   183R
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   185C
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   186G
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   210R
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   211V
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
   212C
   putative phosphatidylinositol 3-phosphate binding site
   160W, 162D, 178R, 179K, 180H, 181H, 182C, 183R, 185C, 186G, 210R, 211V, 212C
   CDD
   cd15720 (FYVE_Hrs)
3. Zn binding site cd...
   166C
   Zn binding site
   166C, 169C, 182C, 185C, 190C, 193C, 212C, 215C
   CDD
   cd15720 (FYVE_Hrs)
   169C
   Zn binding site
   166C, 169C, 182C, 185C, 190C, 193C, 212C, 215C
   CDD
   cd15720 (FYVE_Hrs)
   182C
   Zn binding site
   166C, 169C, 182C, 185C, 190C, 193C, 212C, 215C
   CDD
   cd15720 (FYVE_Hrs)
   185C
   Zn binding site
   166C, 169C, 182C, 185C, 190C, 193C, 212C, 215C
   CDD
   cd15720 (FYVE_Hrs)
   190C
   Zn binding site
   166C, 169C, 182C, 185C, 190C, 193C, 212C, 215C
   CDD
   cd15720 (FYVE_Hrs)
   193C
   Zn binding site
   166C, 169C, 182C, 185C, 190C, 193C, 212C, 215C
   CDD
   cd15720 (FYVE_Hrs)
   212C
   Zn binding site
   166C, 169C, 182C, 185C, 190C, 193C, 212C, 215C
   CDD
   cd15720 (FYVE_Hrs)
   215C
   Zn binding site
   166C, 169C, 182C, 185C, 190C, 193C, 212C, 215C
   CDD
   cd15720 (FYVE_Hrs)

### GO term prediction

#### Biological Process

GO:0006886 intracellular protein transport

#### Molecular Function

GO:0046872 metal ion binding

#### Cellular Component

None predicted.

Generated with InterProScan 5.45-80.0