Protein

## Lalb_11371

Length
1,973 amino acids

### Protein family membership

- Voltage-gated cation channel calcium and sodium (IPR043203)
  - Voltage gated sodium channel, alpha subunit (IPR001696)

### Homologous superfamilies

1. Homologous superfamily
   1 - 63
   - Voltage-dependent channel domain superfamily (IPR027359)
   497 - 615
   - Voltage-dependent channel domain superfamily (IPR027359)
   985 - 1,105
   - Voltage-dependent channel domain superfamily (IPR027359)
   1,343 - 1,465
   - Voltage-dependent channel domain superfamily (IPR027359)

1 200 400 600 800 1000 1200 1400 1600 1800 1973

### Domains and repeats

1. Domain
   1 - 238
   - Ion transport domain (IPR005821)
   506 - 736
   - Ion transport domain (IPR005821)
   995 - 1,302
   - Ion transport domain (IPR005821)
   1,354 - 1,605
   - Ion transport domain (IPR005821)
   1,617 - 1,652
   - Voltage-dependent L-type calcium channel, IQ-associated domain (IPR031649)

1 200 400 600 800 1000 1200 1400 1600 1800 1973

### Detailed signature matches

1. IPR027359
   Voltage-dependent channel domain superfamily
   1. G3DSA:1.20.12...
      1 - 63
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
      985 - 1,105
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
      1,343 - 1,465
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
      497 - 615
      GENE3D
      G3DSA:1.20.120.350 (G3DSA:1.20.120.350)
2. IPR043203
   Voltage-gated cation channel calcium and sodium
   1. PTHR10037 (VOLTAGE-...)
      1 - 1,847
      PANTHER
      PTHR10037 (VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM)
3. IPR001696
   Voltage gated sodium channel, alpha subunit
   1. PR00170 (NACHANNEL)
      1,612 - 1,625
      PRINTS
      PR00170 (NACHANNEL)
      1,577 - 1,596
      PRINTS
      PR00170 (NACHANNEL)
4. IPR005821
   Ion transport domain
   1. PF00520 (Ion_trans)
      1,354 - 1,605
      Pfam
      PF00520 (Ion_trans)
      995 - 1,302
      Pfam
      PF00520 (Ion_trans)
      1 - 238
      Pfam
      PF00520 (Ion_trans)
      506 - 736
      Pfam
      PF00520 (Ion_trans)
5. IPR031649
   Voltage-dependent L-type calcium channel, IQ-associated domain
   1. PF16905 (GPHH)
      1,617 - 1,652
      Pfam
      PF16905 (GPHH)

no IPR
Unintegrated signatures

1. G3DSA:1.10.23...
   1,601 - 1,721
   GENE3D
   G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
2. G3DSA:1.10.28...
   1,467 - 1,600
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
   616 - 737
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
   155 - 237
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
   1,107 - 1,176
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
   1,203 - 1,296
   GENE3D
   G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
3. PTHR10037:SF62 (SOD...)
   1 - 1,847
   PANTHER
   PTHR10037:SF62 (SODIUM CHANNEL PROTEIN 60E)
4. SSF81324 (Voltage-g...)
   1,574 - 1,601
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   1,352 - 1,543
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   168 - 235
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   13 - 107
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   506 - 733
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   994 - 1,147
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
   1,221 - 1,297
   SUPERFAMILY
   SSF81324 (Voltage-gated potassium channels)
5. cd13433 (Na_channel...)
   1,294 - 1,348
   CDD
   cd13433 (Na_channel_gate)

### Other features

1. Coil
   1,734 - 1,754
   COILS
   Coil (Coil)
2. mobidb-lite (disord...)
   824 - 907
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   768 - 788
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   1,749 - 1,781
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   1,834 - 1,890
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   288 - 434
   MobiDB Lite
   mobidb-lite (disorder_prediction)
3. mobidb-lite (Polyam...)
   382 - 422
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   771 - 788
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   855 - 907
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
4. mobidb-lite (Polar)
   364 - 381
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   306 - 355
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar
   1,844 - 1,875
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polar

### Residue annotation

1. putative hydrophob...
   1,310M
   putative hydrophobic latch
   1,310M, 1,311F, 1,312L, 1,313T
   CDD
   cd13433 (Na_channel_gate)
   1,311F
   putative hydrophobic latch
   1,310M, 1,311F, 1,312L, 1,313T
   CDD
   cd13433 (Na_channel_gate)
   1,312L
   putative hydrophobic latch
   1,310M, 1,311F, 1,312L, 1,313T
   CDD
   cd13433 (Na_channel_gate)
   1,313T
   putative hydrophobic latch
   1,310M, 1,311F, 1,312L, 1,313T
   CDD
   cd13433 (Na_channel_gate)

### GO term prediction

#### Biological Process

GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport

#### Molecular Function

GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 cation channel activity

#### Cellular Component

GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane

Generated with InterProScan 5.45-80.0