Protein

## Lalb_05132

Length
983 amino acids

### Protein family membership

- Alanine-tRNA ligase, class IIc (IPR002318)
  - Alanine-tRNA ligase, eukaryota/bacteria (IPR023033)

### Homologous superfamilies

1. Homologous superfamily
   259 - 473
   - Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily (IPR018162)
   517 - 594
   - Translation protein, beta-barrel domain superfamily (IPR009000)
   598 - 762
   - Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily (IPR018163)

1 100 200 300 400 500 600 700 800 900 983

### Domains and repeats

1. Domain
   5 - 768
   - Alanyl-tRNA synthetase, class IIc, core domain (IPR018165)
2. Domain
   9 - 597
   - Alanyl-tRNA synthetase, class IIc, N-terminal (IPR018164)
   696 - 755
   - Threonyl/alanyl tRNA synthetase, SAD (IPR012947)
   817 - 961
   - DHHA1 domain (IPR003156)

1 100 200 300 400 500 600 700 800 900 983

### Detailed signature matches

1. IPR018162
   Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily
   1. SSF101353 (Putative...)
      259 - 473
      SUPERFAMILY
      SSF101353 (Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS))
2. IPR009000
   Translation protein, beta-barrel domain superfamily
   1. SSF50447 (Translati...)
      517 - 594
      SUPERFAMILY
      SSF50447 (Translation proteins)
3. IPR018163
   Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
   1. SSF55186 (ThrRS/Ala...)
      598 - 762
      SUPERFAMILY
      SSF55186 (ThrRS/AlaRS common domain)
4. IPR002318
   Alanine-tRNA ligase, class IIc
   1. PR00980 (TRNASYNTHALA)
      239 - 252
      PRINTS
      PR00980 (TRNASYNTHALA)
      212 - 223
      PRINTS
      PR00980 (TRNASYNTHALA)
      296 - 312
      PRINTS
      PR00980 (TRNASYNTHALA)
      320 - 333
      PRINTS
      PR00980 (TRNASYNTHALA)
      83 - 94
      PRINTS
      PR00980 (TRNASYNTHALA)
   2. TIGR00344
      9 - 946
      TIGRFAMs
      TIGR00344 (TIGR00344)
5. IPR023033
   Alanine-tRNA ligase, eukaryota/bacteria
   1. MF_00036_B (Ala_tRN...)
      1 - 967
      HAMAP
      MF_00036_B (Ala_tRNA_synth_B)
6. IPR018165
   Alanyl-tRNA synthetase, class IIc, core domain
   1. PS50860 (AA_TRNA_LI...)
      5 - 768
      PROSITE profiles
      PS50860 (AA_TRNA_LIGASE_II_ALA)
7. IPR018164
   Alanyl-tRNA synthetase, class IIc, N-terminal
   1. PF01411 (tRNA-synt_2c)
      9 - 597
      Pfam
      PF01411 (tRNA-synt_2c)
8. IPR012947
   Threonyl/alanyl tRNA synthetase, SAD
   1. PF07973 (tRNA_SAD)
      696 - 755
      Pfam
      PF07973 (tRNA_SAD)
   2. SM00863 (tRNA_SAD_4)
      696 - 755
      SMART
      SM00863 (tRNA_SAD_4)
9. IPR003156
   DHHA1 domain
   1. PF02272 (DHHA1)
      817 - 961
      Pfam
      PF02272 (DHHA1)

no IPR
Unintegrated signatures

1. G3DSA:2.40.30...
   505 - 594
   GENE3D
   G3DSA:2.40.30.130 (G3DSA:2.40.30.130)
2. G3DSA:3.10.31...
   855 - 963
   GENE3D
   G3DSA:3.10.310.40 (G3DSA:3.10.310.40)
3. G3DSA:3.30.54.20
   666 - 736
   GENE3D
   G3DSA:3.30.54.20 (G3DSA:3.30.54.20)
4. G3DSA:3.30.93... (B...)
   4 - 255
   GENE3D
   G3DSA:3.30.930.10 (Bira Bifunctional Protein; Domain 2)
5. G3DSA:3.30.98...
   737 - 754
   GENE3D
   G3DSA:3.30.980.10 (G3DSA:3.30.980.10)
   598 - 665
   GENE3D
   G3DSA:3.30.980.10 (G3DSA:3.30.980.10)
6. PTHR11777 (ALANYL-T...)
   1 - 968
   PANTHER
   PTHR11777 (ALANYL-TRNA SYNTHETASE)
7. PTHR11777:SF33 (ALA...)
   1 - 968
   PANTHER
   PTHR11777:SF33 (ALANINE--TRNA LIGASE, CYTOPLASMIC)
8. SSF55681 (Class II ...)
   5 - 258
   SUPERFAMILY
   SSF55681 (Class II aaRS and biotin synthetases)
9. cd00673 (AlaRS_core)
   7 - 254
   CDD
   cd00673 (AlaRS_core)

### Other features

1. Coil
   762 - 789
   COILS
   Coil (Coil)
   816 - 843
   COILS
   Coil (Coil)

### Residue annotation

1. motif 1 cd00673
   25Y
   motif 1
   25Y, 26V, 27H, 28S, 29S
   CDD
   cd00673 (AlaRS_core)
   26V
   motif 1
   25Y, 26V, 27H, 28S, 29S
   CDD
   cd00673 (AlaRS_core)
   27H
   motif 1
   25Y, 26V, 27H, 28S, 29S
   CDD
   cd00673 (AlaRS_core)
   28S
   motif 1
   25Y, 26V, 27H, 28S, 29S
   CDD
   cd00673 (AlaRS_core)
   29S
   motif 1
   25Y, 26V, 27H, 28S, 29S
   CDD
   cd00673 (AlaRS_core)
2. active site cd00673
   52V
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   54L
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   77R
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   98F
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   100M
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   102G
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   103N
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   104W
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   213E
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   214I
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   218V
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   237H
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   238I
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   242L
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   243G
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
   246R
   active site
   52V, 54L, 77R, 98F, 100M, 102G, 103N, 104W, 213E, 214I, 218V, 237H, 238I, 242L, 243G, 246R
   CDD
   cd00673 (AlaRS_core)
3. motif 2 cd00673
   76I
   motif 2
   76I, 77R, 78A
   CDD
   cd00673 (AlaRS_core)
   77R
   motif 2
   76I, 77R, 78A
   CDD
   cd00673 (AlaRS_core)
   78A
   motif 2
   76I, 77R, 78A
   CDD
   cd00673 (AlaRS_core)
4. motif 3 cd00673
   241G
   motif 3
   241G, 242L, 243G, 244L, 245E, 246R
   CDD
   cd00673 (AlaRS_core)
   242L
   motif 3
   241G, 242L, 243G, 244L, 245E, 246R
   CDD
   cd00673 (AlaRS_core)
   243G
   motif 3
   241G, 242L, 243G, 244L, 245E, 246R
   CDD
   cd00673 (AlaRS_core)
   244L
   motif 3
   241G, 242L, 243G, 244L, 245E, 246R
   CDD
   cd00673 (AlaRS_core)
   245E
   motif 3
   241G, 242L, 243G, 244L, 245E, 246R
   CDD
   cd00673 (AlaRS_core)
   246R
   motif 3
   241G, 242L, 243G, 244L, 245E, 246R
   CDD
   cd00673 (AlaRS_core)

### GO term prediction

#### Biological Process

GO:0006419 alanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation

#### Molecular Function

GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding

#### Cellular Component

GO:0005737 cytoplasm

Generated with InterProScan 5.45-80.0