Protein

## Lalb_12116

Length
787 amino acids

### Protein family membership

- Pyrimidine 5'-nucleotidase, eukaryotic (IPR006434)

### Homologous superfamilies

1. Homologous superfamily
   286 - 422
   - Rieske [2Fe-2S] iron-sulphur domain superfamily (IPR036922)
   561 - 781
   - HAD superfamily (IPR023214)
2. Homologous superfamily
   562 - 780
   - HAD-like superfamily (IPR036412)

1 100 200 300 400 500 600 700 787

### Domains and repeats

1. Domain
   293 - 397
   - Rieske [2Fe-2S] iron-sulphur domain (IPR017941)

1 100 200 300 400 500 600 700 787

### Detailed signature matches

1. IPR036922
   Rieske [2Fe-2S] iron-sulphur domain superfamily
   1. G3DSA:2.102.1...
      288 - 422
      GENE3D
      G3DSA:2.102.10.10 (G3DSA:2.102.10.10)
   2. SSF50022 (ISP domain)
      286 - 401
      SUPERFAMILY
      SSF50022 (ISP domain)
2. IPR023214
   HAD superfamily
   1. G3DSA:3.40.50...
      657 - 781
      GENE3D
      G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
      561 - 575
      GENE3D
      G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
3. IPR036412
   HAD-like superfamily
   1. SSF56784 (HAD-like)
      562 - 780
      SUPERFAMILY
      SSF56784 (HAD-like)
4. IPR006434
   Pyrimidine 5'-nucleotidase, eukaryotic
   1. SFLDG01128 (C1.4:_5...)
      561 - 781
      SFLD
      SFLDG01128 (C1.4:_5'-Nucleotidase_Like)
   2. PF05822 (UMPH-1)
      569 - 781
      Pfam
      PF05822 (UMPH-1)
5. IPR017941
   Rieske [2Fe-2S] iron-sulphur domain
   1. PS51296 (RIESKE)
      293 - 397
      PROSITE profiles
      PS51296 (RIESKE)
   2. PF00355 (Rieske)
      293 - 378
      Pfam
      PF00355 (Rieske)

no IPR
Unintegrated signatures

1. G3DSA:1.10.15...
   576 - 656
   GENE3D
   G3DSA:1.10.150.340 (G3DSA:1.10.150.340)
2. PTHR13045 (NT5C3 HY...)
   561 - 786
   PANTHER
   PTHR13045 (NT5C3 HYDROLASE)
3. SFLDS00003 (Haloaci...)
   561 - 781
   SFLD
   SFLDS00003 (Haloacid_Dehalogenase)

### Other features

1. mobidb-lite (disord...)
   1 - 20
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   86 - 191
   MobiDB Lite
   mobidb-lite (disorder_prediction)
2. mobidb-lite (Polyam...)
   133 - 191
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte
   93 - 126
   MobiDB Lite
   mobidb-lite (disorder_prediction)
   Feature: Polyampholyte

### Residue annotation

1. SFLDG01128
   565D
   Mg2+ ligand; nucleophile
   565D
   SFLD
   SFLDG01128 (C1.4:_5'-Nucleotidase_Like)
2. SFLDG01128
   567D
   Mg2+ ligand; general acid (donates proton); general base (activates nucleophile)
   567D
   SFLD
   SFLDG01128 (C1.4:_5'-Nucleotidase_Like)
3. SFLDG01128
   569T
   Stabilizes nucleophilic Asp
   569T
   SFLD
   SFLDG01128 (C1.4:_5'-Nucleotidase_Like)
4. SFLDG01128
   729K
   Binds phosphate
   729K
   SFLD
   SFLDG01128 (C1.4:_5'-Nucleotidase_Like)
5. SFLDG01128
   753D
   Mg2+ ligand
   753D
   SFLD
   SFLDG01128 (C1.4:_5'-Nucleotidase_Like)
6. SFLDG01128
   757D
   Stabilizes nucleophilic Asp
   757D
   SFLD
   SFLDG01128 (C1.4:_5'-Nucleotidase_Like)

### GO term prediction

#### Biological Process

GO:0055114 oxidation-reduction process

#### Molecular Function

GO:0000287 magnesium ion binding
GO:0008253 5'-nucleotidase activity
GO:0051537 2 iron, 2 sulfur cluster binding

#### Cellular Component

GO:0005737 cytoplasm

Generated with InterProScan 5.45-80.0