XM_014420943.1

Protein

Length

582 amino acids

Protein family membership

Ezrin/radixin/moesin-like (IPR000798)
- Ezrin/radixin/moesin (IPR011174)

Homologous superfamilies

Homologous superfamily
5 - 89
Ubiquitin-like domain superfamily (IPR029071)
91 - 200
FERM superfamily, second domain (IPR035963)
Homologous superfamily
85 - 201
FERM/acyl-CoA-binding protein superfamily (IPR014352)
203 - 301
PH-like domain superfamily (IPR011993)
499 - 582
Moesin tail domain superfamily (IPR008954)

1 100 200 300 400 500 582

Domains and repeats

Domain
3 - 208
Band 4.1 domain (IPR019749)
Domain
7 - 297
FERM domain (IPR000299)
333 - 582
Ezrin/radixin/moesin, C-terminal (IPR011259)
Domain
11 - 72
FERM, N-terminal (IPR018979)
202 - 301
FERM, C-terminal PH-like domain (IPR018980)
ERM family, FERM domain C-lobe (IPR041789)
Domain
95 - 208
FERM central domain (IPR019748)

1 100 200 300 400 500 582

Detailed signature matches

IPR029071

Ubiquitin-like domain superfamily
1. SSF54236 (Ubiquitin...)
  
  5 - 89
  
  SUPERFAMILY
  SSF54236 (Ubiquitin-like)
IPR014352

FERM/acyl-CoA-binding protein superfamily
1. G3DSA:1.20.80.10
  
  85 - 201
  
  GENE3D
  G3DSA:1.20.80.10 (G3DSA:1.20.80.10)
IPR035963

FERM superfamily, second domain
1. SSF47031 (Second do...)
  
  91 - 200
  
  SUPERFAMILY
  SSF47031 (Second domain of FERM)
IPR011993

PH-like domain superfamily
1. G3DSA:2.30.29.30
  
  203 - 301
  
  GENE3D
  G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
IPR008954

Moesin tail domain superfamily
1. SSF48678 (Moesin ta...)
  
  499 - 582
  
  SUPERFAMILY
  SSF48678 (Moesin tail domain)
2. G3DSA:1.25.40...
  
  500 - 582
  
  GENE3D
  G3DSA:1.25.40.1020 (G3DSA:1.25.40.1020)
IPR000798

Ezrin/radixin/moesin-like
1. PR00661 (ERMFAMILY)
  
  286 - 305
  
  PRINTS
  PR00661 (ERMFAMILY)
  
  71 - 90
  
  PRINTS
  PR00661 (ERMFAMILY)
  
  559 - 580
  
  PRINTS
  PR00661 (ERMFAMILY)
  
  19 - 38
  
  PRINTS
  PR00661 (ERMFAMILY)
  
  211 - 231
  
  PRINTS
  PR00661 (ERMFAMILY)
  
  537 - 558
  
  PRINTS
  PR00661 (ERMFAMILY)
  
  115 - 136
  
  PRINTS
  PR00661 (ERMFAMILY)
  
  161 - 178
  
  PRINTS
  PR00661 (ERMFAMILY)
IPR011174

Ezrin/radixin/moesin
1. PIRSF002305 (ERM)
  
  1 - 582
  
  PIRSF
  PIRSF002305 (ERM)
IPR019749

Band 4.1 domain
1. SM00295 (B41_5)
  
  3 - 208
  
  SMART
  SM00295 (B41_5)
2. PR00935 (BAND41)
  
  39 - 51
  
  PRINTS
  PR00935 (BAND41)
  
  106 - 119
  
  PRINTS
  PR00935 (BAND41)
  
  119 - 139
  
  PRINTS
  PR00935 (BAND41)
  
  188 - 204
  
  PRINTS
  PR00935 (BAND41)
IPR000299

FERM domain
1. PS50057 (FERM_3)
  
  7 - 297
  
  PROSITE profiles
  PS50057 (FERM_3)
IPR018979

FERM, N-terminal
1. PF09379 (FERM_N)
  
  11 - 72
  
  Pfam
  PF09379 (FERM_N)
IPR019748

FERM central domain
1. PF00373 (FERM_M)
  
  95 - 208
  
  Pfam
  PF00373 (FERM_M)
2. cd14473 (FERM_B-lobe)
  
  100 - 200
  
  CDD
  cd14473 (FERM_B-lobe)
IPR018980

FERM, C-terminal PH-like domain
1. PF09380 (FERM_C)
  
  212 - 300
  
  Pfam
  PF09380 (FERM_C)
2. SM01196 (FERM_C_3)
  
  212 - 301
  
  SMART
  SM01196 (FERM_C_3)
IPR041789

ERM family, FERM domain C-lobe
1. cd13194 (FERM_C_ERM)
  
  202 - 298
  
  CDD
  cd13194 (FERM_C_ERM)
IPR011259

Ezrin/radixin/moesin, C-terminal
1. PF00769 (ERM)
  
  333 - 582
  
  Pfam
  PF00769 (ERM)
IPR019747

FERM conserved site
1. PS00660 (FERM_1)
  
  60 - 90
  
  PROSITE patterns
  PS00660 (FERM_1)
2. PS00661 (FERM_2)
  
  178 - 207
  
  PROSITE patterns
  PS00661 (FERM_2)

no IPR

Unintegrated signatures

G3DSA:1.20.5.450

454 - 499

GENE3D
G3DSA:1.20.5.450 (G3DSA:1.20.5.450)

302 - 453

GENE3D
G3DSA:1.20.5.450 (G3DSA:1.20.5.450)
G3DSA:3.10.20.90

6 - 84

GENE3D
G3DSA:3.10.20.90 (G3DSA:3.10.20.90)
PTHR23281 (MERLIN/M...)

5 - 582

PANTHER
PTHR23281 (MERLIN/MOESIN/EZRIN/RADIXIN)
PTHR23281:SF18 (MOE...)

5 - 582

PANTHER
PTHR23281:SF18 (MOESIN/EZRIN/RADIXIN HOMOLOG 1)
SSF50729 (PH domain...)

201 - 342

SUPERFAMILY
SSF50729 (PH domain-like)
cd17187 (FERM_F1_ERM)

7 - 89

CDD
cd17187 (FERM_F1_ERM)

Other features

Coil

304 - 468

COILS
Coil (Coil)

513 - 540

COILS
Coil (Coil)
mobidb-lite (disord...)

471 - 519

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polyam...)

479 - 519

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

Residue annotation

homodimer interfac...

244W

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

245S

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

247I

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

248R

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

249N

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

250I

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

251S

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

252F

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

253N

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

262I

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

283L

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

286C

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

287M

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

290H

homodimer interface
244W, 245S, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)
peptide binding si...

244W

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

247I

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

248R

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

249N

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

250I

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

251S

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

252F

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

253N

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

254D

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

262I

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

283L

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

286C

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

287M

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)

290H

peptide binding site
244W, 247I, 248R, 249N, 250I, 251S, 252F, 253N, 254D, 262I, 283L, 286C, 287M, 290H
CDD
cd13194 (FERM_C_ERM)
phosphoinositide b...

280K

phosphoinositide binding site
280K, 284A
CDD
cd13194 (FERM_C_ERM)

284A

phosphoinositide binding site
280K, 284A
CDD
cd13194 (FERM_C_ERM)
actin binding site...

283L

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

284A

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

285L

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

286C

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

287M

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

288G

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

289N

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

290H

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

291E

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

292L

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

293Y

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

294M

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

295R

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

296R

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

297R

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

298K

actin binding site 2
283L, 284A, 285L, 286C, 287M, 288G, 289N, 290H, 291E, 292L, 293Y, 294M, 295R, 296R, 297R, 298K
CDD
cd13194 (FERM_C_ERM)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding

Cellular Component

GO:0005856 cytoskeleton

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Entry type

Status

Per-residue features