XM_014425620.1

Protein

Length

403 amino acids

Protein family membership

S-adenosylmethionine synthetase (IPR002133)

Homologous superfamilies

Homologous superfamily
26 - 131
S-adenosylmethionine synthetase superfamily (IPR022636)
137 - 259
S-adenosylmethionine synthetase superfamily (IPR022636)
260 - 400
S-adenosylmethionine synthetase superfamily (IPR022636)

1 50 100 150 200 250 300 350 403

Domains and repeats

Domain
26 - 123
S-adenosylmethionine synthetase, N-terminal (IPR022628)
138 - 258
S-adenosylmethionine synthetase, central domain (IPR022629)
260 - 397
S-adenosylmethionine synthetase, C-terminal (IPR022630)

1 50 100 150 200 250 300 350 403

Detailed signature matches

IPR022636

S-adenosylmethionine synthetase superfamily
1. SSF55973 (S-adenosy...)
  
  260 - 400
  
  SUPERFAMILY
  SSF55973 (S-adenosylmethionine synthetase)
  
  26 - 131
  
  SUPERFAMILY
  SSF55973 (S-adenosylmethionine synthetase)
  
  137 - 259
  
  SUPERFAMILY
  SSF55973 (S-adenosylmethionine synthetase)
IPR002133

S-adenosylmethionine synthetase
1. TIGR01034
  
  27 - 401
  
  TIGRFAMs
  TIGR01034 (TIGR01034)
2. PTHR11964 (S-ADENOS...)
  
  8 - 401
  
  PANTHER
  PTHR11964 (S-ADENOSYLMETHIONINE SYNTHETASE)
3. PIRSF000497 (MAT)
  
  21 - 403
  
  PIRSF
  PIRSF000497 (MAT)
4. MF_00086 (S_AdoMet_...)
  
  24 - 402
  
  HAMAP
  MF_00086 (S_AdoMet_synth1)
IPR022628

S-adenosylmethionine synthetase, N-terminal
1. PF00438 (S-AdoMet_s...)
  
  26 - 123
  
  Pfam
  PF00438 (S-AdoMet_synt_N)
IPR022629

S-adenosylmethionine synthetase, central domain
1. PF02772 (S-AdoMet_s...)
  
  138 - 258
  
  Pfam
  PF02772 (S-AdoMet_synt_M)
IPR022630

S-adenosylmethionine synthetase, C-terminal
1. PF02773 (S-AdoMet_s...)
  
  260 - 397
  
  Pfam
  PF02773 (S-AdoMet_synt_C)
IPR022631

S-adenosylmethionine synthetase, conserved site
1. PS00377 (ADOMET_SYN...)
  
  286 - 294
  
  PROSITE patterns
  PS00377 (ADOMET_SYNTHASE_2)
2. PS00376 (ADOMET_SYN...)
  
  139 - 149
  
  PROSITE patterns
  PS00376 (ADOMET_SYNTHASE_1)

no IPR

Unintegrated signatures

G3DSA:3.30.30...

300 - 396

GENE3D
G3DSA:3.30.300.10 (G3DSA:3.30.300.10)

137 - 159

GENE3D
G3DSA:3.30.300.10 (G3DSA:3.30.300.10)

263 - 299

GENE3D
G3DSA:3.30.300.10 (G3DSA:3.30.300.10)

33 - 136

GENE3D
G3DSA:3.30.300.10 (G3DSA:3.30.300.10)

27 - 32

GENE3D
G3DSA:3.30.300.10 (G3DSA:3.30.300.10)

160 - 262

GENE3D
G3DSA:3.30.300.10 (G3DSA:3.30.300.10)
PTHR11964:SF12 (S-A...)

8 - 401

PANTHER
PTHR11964:SF12 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)
cd18079 (S-AdoMet_synt)

27 - 399

CDD
cd18079 (S-AdoMet_synt)

Residue annotation

homodimer interfac...

27L

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

28F

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

29T

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

31E

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

65E

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

67V

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

69K

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

74L

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

76C

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

77G

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

78E

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

142D

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

143Q

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

144G

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

145L

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

147F

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

189K

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

191Q

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

193T

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

210T

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

212V

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

251H

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

254P

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

265C

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

266D

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

267A

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

269L

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

270T

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

271G

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

272R

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

275I

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

280G

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

281G

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

282W

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

283G

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

284A

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

285H

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

286G

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

287G

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

289A

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

293K

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

325Q

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

327S

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

328Y

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

329A

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

330I

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

331G

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

336I

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

337S

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)

339T

homodimer interface
27L, 28F, 29T, 31E, 65E, 67V, 69K, 74L, 76C, 77G, 78E, 142D, 143Q, 144G, 145L, 147F, 189K, 191Q, 193T, 210T, 212V, 251H, 254P, 265C, 266D, 267A, 269L, 270T, 271G, 272R, 275I, 280G, 281G, 282W, 283G, 284A, 285H, 286G, 287G, 289A, 293K, 325Q, 327S, 328Y, 329A, 330I, 331G, 336I, 337S, 339T
CDD
cd18079 (S-AdoMet_synt)
ATP binding site c...

31E

ATP binding site
31E, 37H, 38P, 187D, 189K, 273K
CDD
cd18079 (S-AdoMet_synt)

37H

ATP binding site
31E, 37H, 38P, 187D, 189K, 273K
CDD
cd18079 (S-AdoMet_synt)

38P

ATP binding site
31E, 37H, 38P, 187D, 189K, 273K
CDD
cd18079 (S-AdoMet_synt)

187D

ATP binding site
31E, 37H, 38P, 187D, 189K, 273K
CDD
cd18079 (S-AdoMet_synt)

189K

ATP binding site
31E, 37H, 38P, 187D, 189K, 273K
CDD
cd18079 (S-AdoMet_synt)

273K

ATP binding site
31E, 37H, 38P, 187D, 189K, 273K
CDD
cd18079 (S-AdoMet_synt)
active site cd18079

31E

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

37H

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

38P

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

39D

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

63A

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

78E

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

121Q

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

124E

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

125I

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

141G

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

142D

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

187D

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

189K

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

214S

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

255C

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

257E

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

258F

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

260L

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

266D

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

272R

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

273K

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

287G

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

288G

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

289A

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

293K

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

297K

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

299D

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

330I

active site
31E, 37H, 38P, 39D, 63A, 78E, 121Q, 124E, 125I, 141G, 142D, 187D, 189K, 214S, 255C, 257E, 258F, 260L, 266D, 272R, 273K, 287G, 288G, 289A, 293K, 297K, 299D, 330I
CDD
cd18079 (S-AdoMet_synt)

GO term prediction

Biological Process

GO:0006556 S-adenosylmethionine biosynthetic process

Molecular Function

GO:0004478 methionine adenosyltransferase activity
GO:0005524 ATP binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features