XM_014429314.1

Protein

Length

446 amino acids

Protein family membership

Arfaptin family (IPR030798)

Homologous superfamilies

Homologous superfamily
17 - 127
PDZ superfamily (IPR036034)
143 - 354
AH/BAR domain superfamily (IPR027267)

1 50 100 150 200 250 300 350 400 446

Domains and repeats

Domain
23 - 106
PDZ domain (IPR001478)
118 - 361
Arfaptin homology (AH) domain (IPR010504)
PICK1, BAR domain (IPR037959)

1 50 100 150 200 250 300 350 400 446

Detailed signature matches

IPR036034

PDZ superfamily
1. G3DSA:2.30.42.10
  
  17 - 127
  
  GENE3D
  G3DSA:2.30.42.10 (G3DSA:2.30.42.10)
2. SSF50156 (PDZ domai...)
  
  22 - 101
  
  SUPERFAMILY
  SSF50156 (PDZ domain-like)
IPR027267

AH/BAR domain superfamily
1. SSF103657 (BAR/IMD ...)
  
  143 - 353
  
  SUPERFAMILY
  SSF103657 (BAR/IMD domain-like)
2. G3DSA:1.20.12... (A...)
  
  146 - 354
  
  GENE3D
  G3DSA:1.20.1270.60 (Arfaptin)
IPR030798

Arfaptin family
1. PTHR12141 (ARFAPTIN...)
  
  5 - 391
  
  PANTHER
  PTHR12141 (ARFAPTIN-RELATEDADP-RIBOSYLATION FACTOR INTERACTING PROTEIN/PROTEIN KINASE C ALPHA BINDING PROTEIN)
IPR001478

PDZ domain
1. PS50106 (PDZ)
  
  23 - 106
  
  PROSITE profiles
  PS50106 (PDZ)
2. PF00595 (PDZ)
  
  24 - 101
  
  Pfam
  PF00595 (PDZ)
3. SM00228 (pdz_new)
  
  32 - 106
  
  SMART
  SM00228 (pdz_new)
IPR010504

Arfaptin homology (AH) domain
1. PS50870 (AH)
  
  145 - 358
  
  PROSITE profiles
  PS50870 (AH)
2. SM01015 (Arfaptin_2)
  
  118 - 353
  
  SMART
  SM01015 (Arfaptin_2)
3. PF06456 (Arfaptin)
  
  118 - 352
  
  Pfam
  PF06456 (Arfaptin)
IPR037959

PICK1, BAR domain
1. cd07659 (BAR_PICK1)
  
  147 - 361
  
  CDD
  cd07659 (BAR_PICK1)

no IPR

Unintegrated signatures

PTHR12141:SF1 (PRKC...)

5 - 391

PANTHER
PTHR12141:SF1 (PRKCA-BINDING PROTEIN)
cd00992 (PDZ_signaling)

23 - 101

CDD
cd00992 (PDZ_signaling)

Other features

Coil

377 - 397

COILS
Coil (Coil)

Residue annotation

protein binding si...

33L

protein binding site
33L, 34I, 35G, 36I, 38I, 87V, 88A, 91I, 92Q
CDD
cd00992 (PDZ_signaling)

34I

protein binding site
33L, 34I, 35G, 36I, 38I, 87V, 88A, 91I, 92Q
CDD
cd00992 (PDZ_signaling)

35G

protein binding site
33L, 34I, 35G, 36I, 38I, 87V, 88A, 91I, 92Q
CDD
cd00992 (PDZ_signaling)

36I

protein binding site
33L, 34I, 35G, 36I, 38I, 87V, 88A, 91I, 92Q
CDD
cd00992 (PDZ_signaling)

38I

protein binding site
33L, 34I, 35G, 36I, 38I, 87V, 88A, 91I, 92Q
CDD
cd00992 (PDZ_signaling)

87V

protein binding site
33L, 34I, 35G, 36I, 38I, 87V, 88A, 91I, 92Q
CDD
cd00992 (PDZ_signaling)

88A

protein binding site
33L, 34I, 35G, 36I, 38I, 87V, 88A, 91I, 92Q
CDD
cd00992 (PDZ_signaling)

91I

protein binding site
33L, 34I, 35G, 36I, 38I, 87V, 88A, 91I, 92Q
CDD
cd00992 (PDZ_signaling)

92Q

protein binding site
33L, 34I, 35G, 36I, 38I, 87V, 88A, 91I, 92Q
CDD
cd00992 (PDZ_signaling)
dimer interface cd...

163M

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

164Y

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

170H

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

174V

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

177A

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

180G

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

181L

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

184V

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

187A

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

188F

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

192F

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

194G

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

195I

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

198R

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

201Q

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

202P

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

207A

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

208F

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

210S

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

211F

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

214Y

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

218M

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

327H

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

331I

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

332V

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

335L

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

336H

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

338F

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

339V

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

346Y

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

347E

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

349G

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)

350N

dimer interface
163M, 164Y, 170H, 174V, 177A, 180G, 181L, 184V, 187A, 188F, 192F, 194G, 195I, 198R, 201Q, 202P, 207A, 208F, 210S, 211F, 214Y, 218M, 327H, 331I, 332V, 335L, 336H, 338F, 339V, 346Y, 347E, 349G, 350N
CDD
cd07659 (BAR_PICK1)
putative Rac bindi...

169D

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

172K

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

175L

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

176K

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

179Y

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

180G

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

182L

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

183Q

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

184V

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

186K

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

187A

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

223I

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

226L

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

230K

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

233L

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

234S

putative Rac binding site
169D, 172K, 175L, 176K, 179Y, 180G, 182L, 183Q, 184V, 186K, 187A, 223I, 226L, 230K, 233L, 234S
CDD
cd07659 (BAR_PICK1)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding
GO:0019904 protein domain specific binding

Cellular Component