XM_014435428.1

Protein

Length

1,129 amino acids

Protein family membership

Ras-like guanine nucleotide exchange factor (IPR008937)

Homologous superfamilies

Homologous superfamily
1 - 201
Dbl homology (DH) domain superfamily (IPR035899)
389 - 1,103
Ras guanine nucleotide exchange factor domain superfamily (IPR023578)
Homologous superfamily
193 - 375
PH-like domain superfamily (IPR011993)
916 - 1,123
Ras guanine-nucleotide exchange factor catalytic domain superfamily (IPR036964)

1 200 400 600 800 1000 1129

Domains and repeats

Domain
1 - 183
Dbl homology (DH) domain (IPR000219)
213 - 352
Pleckstrin homology domain (IPR001849)
396 - 497
Ras-like guanine nucleotide exchange factor, N-terminal (IPR000651)
915 - 1,129
Ras guanine-nucleotide exchange factors catalytic domain (IPR001895)

1 200 400 600 800 1000 1129

Detailed signature matches

IPR035899

Dbl homology (DH) domain superfamily
1. G3DSA:1.20.90...
  
  1 - 192
  
  GENE3D
  G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
2. SSF48065 (DBL homol...)
  
  3 - 201
  
  SUPERFAMILY
  SSF48065 (DBL homology domain (DH-domain))
IPR011993

PH-like domain superfamily
1. G3DSA:2.30.29.30
  
  193 - 375
  
  GENE3D
  G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
IPR023578

Ras guanine nucleotide exchange factor domain superfamily
1. SSF48366 (Ras GEF)
  
  820 - 1,103
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
  
  389 - 451
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
IPR036964

Ras guanine-nucleotide exchange factor catalytic domain superfamily
1. G3DSA:1.10.84... (S...)
  
  916 - 1,123
  
  GENE3D
  G3DSA:1.10.840.10 (Son of sevenless (Sos) protein Chain)
IPR008937

Ras-like guanine nucleotide exchange factor
1. PTHR23113 (GUANINE ...)
  
  2 - 1,107
  
  PANTHER
  PTHR23113 (GUANINE NUCLEOTIDE EXCHANGE FACTOR)
IPR000219

Dbl homology (DH) domain
1. PF00621 (RhoGEF)
  
  5 - 180
  
  Pfam
  PF00621 (RhoGEF)
2. PS50010 (DH_2)
  
  1 - 183
  
  PROSITE profiles
  PS50010 (DH_2)
3. SM00325 (RhoGEF_3)
  
  1 - 182
  
  SMART
  SM00325 (RhoGEF_3)
4. cd00160 (RhoGEF)
  
  5 - 181
  
  CDD
  cd00160 (RhoGEF)
IPR001849

Pleckstrin homology domain
1. SM00233 (PH_update)
  
  214 - 352
  
  SMART
  SM00233 (PH_update)
2. PS50003 (PH_DOMAIN)
  
  213 - 350
  
  PROSITE profiles
  PS50003 (PH_DOMAIN)
IPR000651

Ras-like guanine nucleotide exchange factor, N-terminal
1. SM00229 (rasgefn_5)
  
  396 - 497
  
  SMART
  SM00229 (rasgefn_5)
2. cd06224 (REM)
  
  405 - 461
  
  CDD
  cd06224 (REM)
3. PF00618 (RasGEF_N)
  
  400 - 459
  
  Pfam
  PF00618 (RasGEF_N)
IPR001895

Ras guanine-nucleotide exchange factors catalytic domain
1. cd00155 (RasGEF)
  
  915 - 1,102
  
  CDD
  cd00155 (RasGEF)
2. PF00617 (RasGEF)
  
  922 - 1,100
  
  Pfam
  PF00617 (RasGEF)
3. SM00147 (RasGEF_3)
  
  915 - 1,128
  
  SMART
  SM00147 (RasGEF_3)
4. PS50009 (RASGEF_CAT)
  
  919 - 1,129
  
  PROSITE profiles
  PS50009 (RASGEF_CAT)
IPR019804

Ras guanine-nucleotide exchange factor, conserved site
1. PS00720 (RASGEF)
  
  1,068 - 1,098
  
  PROSITE patterns
  PS00720 (RASGEF)

no IPR

Unintegrated signatures

G3DSA:1.20.87... (S...)

381 - 486

GENE3D
G3DSA:1.20.870.10 (Son of sevenless (SoS) protein Chain: S domain 1)

791 - 906

GENE3D
G3DSA:1.20.870.10 (Son of sevenless (SoS) protein Chain: S domain 1)
PTHR23113:SF316

2 - 1,107

PANTHER
PTHR23113:SF316 (PTHR23113:SF316)
SSF50729 (PH domain...)

192 - 351

SUPERFAMILY
SSF50729 (PH domain-like)

Other features

Coil

163 - 193

COILS
Coil (Coil)
mobidb-lite (disord...)

798 - 825

MobiDB Lite
mobidb-lite (disorder_prediction)

483 - 504

MobiDB Lite
mobidb-lite (disorder_prediction)

649 - 673

MobiDB Lite
mobidb-lite (disorder_prediction)

705 - 755

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polar)

489 - 504

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

722 - 755

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

798 - 813

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

GTPase interaction...

8A

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

105T

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

132E

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

133T

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

136T

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

137Y

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

139M

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

140H

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

143P

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

144R

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

147I

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

148T

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

151E

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

177S

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)

181H

GTPase interaction site
8A, 105T, 132E, 133T, 136T, 137Y, 139M, 140H, 143P, 144R, 147I, 148T, 151E, 177S, 181H
CDD
cd00160 (RhoGEF)
Ras interaction si...

948W

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

949M

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

950K

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

960I

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

961I

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

963M

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

964T

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

965R

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

967F

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

968N

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

971S

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

972Q

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

975V

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,008N

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,011L

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,012Q

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,014C

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,015A

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,016A

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,018T

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,019N

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,020S

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,021A

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,023Y

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,024R

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,044Q

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,047V

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,052R

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,053F

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,054R

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,057R

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,070Y

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,071L

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,072G

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,075L

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,076T

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,077D

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,079S

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,080F

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,081I

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,083E

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,084G

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,085T

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,086P

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

1,101M

Ras interaction site
948W, 949M, 950K, 960I, 961I, 963M, 964T, 965R, 967F, 968N, 971S, 972Q, 975V, 1,008N, 1,011L, 1,012Q, 1,014C, 1,015A, 1,016A, 1,018T, 1,019N, 1,020S, 1,021A, 1,023Y, 1,024R, 1,044Q, 1,047V, 1,052R, 1,053F, 1,054R, 1,057R, 1,070Y, 1,071L, 1,072G, 1,075L, 1,076T, 1,077D, 1,079S, 1,080F, 1,081I, 1,083E, 1,084G, 1,085T, 1,086P, 1,101M
CDD
cd00155 (RasGEF)

GO term prediction

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features