XM_014439256.1

Protein

Length

306 amino acids

Protein family membership

G protein-coupled receptor, rhodopsin-like (IPR000276)
- Orexin receptor family (IPR000204)

Homologous superfamilies

None predicted.

Domains and repeats

Domain
1 - 256
GPCR, rhodopsin-like, 7TM (IPR017452)

1 50 100 150 200 250 306

Detailed signature matches

IPR000276

G protein-coupled receptor, rhodopsin-like
1. PS00237 (G_PROTEIN_...)
  
  56 - 72
  
  PROSITE patterns
  PS00237 (G_PROTEIN_RECEP_F1_1)
2. PR00237 (GPCRRHODOPSN)
  
  238 - 264
  
  PRINTS
  PR00237 (GPCRRHODOPSN)
  
  84 - 105
  
  PRINTS
  PR00237 (GPCRRHODOPSN)
  
  138 - 161
  
  PRINTS
  PR00237 (GPCRRHODOPSN)
  
  198 - 222
  
  PRINTS
  PR00237 (GPCRRHODOPSN)
  
  50 - 72
  
  PRINTS
  PR00237 (GPCRRHODOPSN)
  
  5 - 26
  
  PRINTS
  PR00237 (GPCRRHODOPSN)
IPR000204

Orexin receptor family
1. PR01064 (OREXINR)
  
  23 - 39
  
  PRINTS
  PR01064 (OREXINR)
  
  113 - 129
  
  PRINTS
  PR01064 (OREXINR)
  
  75 - 86
  
  PRINTS
  PR01064 (OREXINR)
IPR017452

GPCR, rhodopsin-like, 7TM
1. PF00001 (7tm_1)
  
  1 - 256
  
  Pfam
  PF00001 (7tm_1)
2. PS50262 (G_PROTEIN_...)
  
  1 - 256
  
  PROSITE profiles
  PS50262 (G_PROTEIN_RECEP_F1_2)

no IPR

Unintegrated signatures

G3DSA:1.20.10...

1 - 295

GENE3D
G3DSA:1.20.1070.10 (G3DSA:1.20.1070.10)
PTHR45695 (FAMILY N...)

1 - 272

PANTHER
PTHR45695 (FAMILY NOT NAMED)
PTHR45695:SF5 (SI:D...)

1 - 272

PANTHER
PTHR45695:SF5 (SI:DKEY-1H24.2)
SSF81321 (Family A ...)

1 - 284

SUPERFAMILY
SSF81321 (Family A G protein-coupled receptor-like)
cd15208 (7tmA_OXR)

1 - 267

CDD
cd15208 (7tmA_OXR)

Residue annotation

putative peptide l...

27T

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

30W

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

31D

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

43C

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

44K

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

45L

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

46I

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

47L

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

48Y

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

50Q

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

51T

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

54V

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

97L

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

99L

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

100D

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

101L

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

102P

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

103E

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

134E

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

137F

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

138S

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

139A

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

141K

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

142I

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

143G

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

145L

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

146Y

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

213Y

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

216V

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

217H

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

219L

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

220S

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

223R

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

237I

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

238S

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

239M

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

242H

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

245C

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

246Y

putative peptide ligand binding pocket
27T, 30W, 31D, 43C, 44K, 45L, 46I, 47L, 48Y, 50Q, 51T, 54V, 97L, 99L, 100D, 101L, 102P, 103E, 134E, 137F, 138S, 139A, 141K, 142I, 143G, 145L, 146Y, 213Y, 216V, 217H, 219L, 220S, 223R, 237I, 238S, 239M, 242H, 245C, 246Y
CDD
cd15208 (7tmA_OXR)

GO term prediction

Biological Process

GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior

Molecular Function

GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features