Accession_ID	Pathway_Count	Pathway_IDs	Pathway_Names
APLA012619-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA004610-PA	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
APLA007932-PA	5	Reactome: R-HSA-381426;Reactome: R-HSA-901042;Reactome: R-HSA-879415;Reactome: R-HSA-8957275;Reactome: R-HSA-532668	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Calnexin/calreticulin cycle";"Advanced glycosylation endproduct receptor signaling";"Post-translational protein phosphorylation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
APLA014054-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA004539-PA	2	KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386	"Pyruvate metabolism";"Methylglyoxal degradation I"
APLA001069-PA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
APLA002485-PA	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
APLA009411-PA	7	Reactome: R-HSA-5635838;Reactome: R-HSA-5632684;Reactome: R-HSA-5632681;Reactome: R-HSA-373080;Reactome: R-HSA-5358346;Reactome: R-HSA-5658034;Reactome: R-HSA-5362798	"Activation of SMO";"Hedgehog 'on' state";"Ligand-receptor interactions";"Class B/2 (Secretin family receptors)";"Hedgehog ligand biogenesis";"HHAT G278V abrogates palmitoylation of Hh-Np";"Release of Hh-Np from the secreting cell"
APLA007415-PA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
APLA001320-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA001833-PA	6	Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2467813	"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids"
APLA008836-PA	56	Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-174084;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-5678895;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-450408;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-5362768;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-1236978;Reactome: R-HSA-1236974	"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of AXIN";"UCH proteinases";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"Defective CFTR causes cystic fibrosis";"Separation of Sister Chromatids";"Neddylation";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Cross-presentation of soluble exogenous antigens (endosomes)";"ER-Phagosome pathway"
APLA011261-PA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
APLA005238-PA	2	KEGG: 00970+6.1.1.5;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
APLA012200-PA	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
APLA014835-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA008491-PA	1	Reactome: R-HSA-5657655	"MGMT-mediated DNA damage reversal"
APLA003249-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA012039-PA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
APLA008532-PA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA003098-PA	7	MetaCyc: PWY-6840;Reactome: R-HSA-174403;Reactome: R-HSA-5578999;KEGG: 00480+6.3.2.2;MetaCyc: PWY-8043;MetaCyc: PWY-7255;KEGG: 00270+6.3.2.2	"Homoglutathione biosynthesis";"Glutathione synthesis and recycling";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Glutathione metabolism";"Ophthalmate biosynthesis";"Ergothioneine biosynthesis I (bacteria)";"Cysteine and methionine metabolism"
APLA005741-PA	10	MetaCyc: PWY-5497;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-5030;MetaCyc: PWY-3841;MetaCyc: PWY-7909;MetaCyc: PWY-1722;MetaCyc: PWY-2201;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-6613;Reactome: R-HSA-196757	"Purine nucleobases degradation II (anaerobic)";"One carbon pool by folate";"L-histidine degradation III";"Folate transformations II (plants)";"Formaldehyde oxidation VII (THF pathway)";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate transformations I";"Carbon fixation pathways in prokaryotes";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Metabolism of folate and pterines"
APLA000197-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA000708-PA	3	Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2206291	"HS-GAG degradation";"Neutrophil degranulation";"MPS IIIC - Sanfilippo syndrome C"
APLA014921-PA	5	Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-72163	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"mRNA Splicing - Major Pathway"
APLA000210-PA	13	Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA006635-PA	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
APLA005792-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA004068-PA	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
APLA000402-PA	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
APLA003085-PA	13	Reactome: R-HSA-186797;Reactome: R-HSA-1650814;Reactome: R-HSA-419037;Reactome: R-HSA-2022090;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216;Reactome: R-HSA-3000157;Reactome: R-HSA-2243919;Reactome: R-HSA-1474244;Reactome: R-HSA-216083;Reactome: R-HSA-3000178;Reactome: R-HSA-3000171;Reactome: R-HSA-2214320	"Signaling by PDGF";"Collagen biosynthesis and modifying enzymes";"NCAM1 interactions";"Assembly of collagen fibrils and other multimeric structures";"Collagen degradation";"Collagen chain trimerization";"Laminin interactions";"Crosslinking of collagen fibrils";"Extracellular matrix organization";"Integrin cell surface interactions";"ECM proteoglycans";"Non-integrin membrane-ECM interactions";"Anchoring fibril formation"
APLA005049-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA006685-PA	2	Reactome: R-HSA-73621;Reactome: R-HSA-500753	"Pyrimidine catabolism";"Pyrimidine biosynthesis"
APLA009090-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA001603-PA	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
APLA011572-PA	5	Reactome: R-HSA-1660499;Reactome: R-HSA-6798695;Reactome: R-HSA-8876198;Reactome: R-HSA-8873719;Reactome: R-HSA-1445148	"Synthesis of PIPs at the plasma membrane";"Neutrophil degranulation";"RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
APLA010286-PA	3	Reactome: R-HSA-4090294;Reactome: R-HSA-3899300;Reactome: R-HSA-3232118	"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors";"SUMOylation of transcription factors"
APLA015399-PA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
APLA005549-PA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
APLA006774-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA006992-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA005336-PA	27	Reactome: R-HSA-9610379;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-4085377;Reactome: R-HSA-180746;Reactome: R-HSA-3301854;Reactome: R-HSA-4570464;Reactome: R-HSA-159230;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-3371453;Reactome: R-HSA-168333;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-5619107;Reactome: R-HSA-170822	"HCMV Late Events";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of SUMOylation proteins";"Nuclear import of Rev protein";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of RNA binding proteins";"Transport of the SLBP Dependant Mature mRNA";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"Regulation of HSF1-mediated heat shock response";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein"
APLA003890-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA004081-PA	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
APLA001620-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA000516-PA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
APLA008022-PA	4	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling"
APLA011337-PA	4	Reactome: R-HSA-68884;Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-2132295	"Mitotic Telophase/Cytokinesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"MHC class II antigen presentation"
APLA000903-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA004341-PA	3	Reactome: R-HSA-8951664;Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Neddylation";"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA011125-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA008519-PA	5	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-201722;Reactome: R-HSA-8866654	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of the beta-catenin:TCF transactivating complex";"E3 ubiquitin ligases ubiquitinate target proteins"
APLA002395-PA	2	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
APLA007291-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA009984-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA009924-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA010550-PA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
APLA001607-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA007372-PA	1	Reactome: R-HSA-419771	"Opsins"
APLA007435-PA	6	KEGG: 00330+2.7.2.11;KEGG: 00332+2.7.2.11+1.2.1.41;MetaCyc: PWY-6922;KEGG: 00330+2.7.2.11+1.2.1.41;KEGG: 00332+2.7.2.11;Reactome: R-HSA-8964539	"Arginine and proline metabolism";"Carbapenem biosynthesis";"L-Ndelta-acetylornithine biosynthesis";"Arginine and proline metabolism";"Carbapenem biosynthesis";"Glutamate and glutamine metabolism"
APLA007689-PA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
APLA003187-PA	14	Reactome: R-HSA-167238;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-167152;Reactome: R-HSA-6796648;Reactome: R-HSA-167287	"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Formation of HIV elongation complex in the absence of HIV Tat";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery"
APLA012893-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA004787-PA	2	Reactome: R-HSA-8963888;Reactome: R-HSA-8866423	"Chylomicron assembly";"VLDL assembly"
APLA010382-PA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
APLA008197-PA	5	MetaCyc: PWY-7159;Reactome: R-HSA-189451;KEGG: 00860+4.1.1.37;MetaCyc: PWY-5531;MetaCyc: PWY-7766	"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)";"Heme b biosynthesis IV (Gram-positive bacteria)"
APLA003771-PA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
APLA005271-PA	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
APLA010940-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA007739-PA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
APLA002181-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA012998-PA	1	Reactome: R-HSA-5635838	"Activation of SMO"
APLA005270-PA	6	MetaCyc: PWY-7165;MetaCyc: PWY-2221;KEGG: 00030+3.1.1.17;MetaCyc: PWY-5530;KEGG: 00930+3.1.1.17;KEGG: 00053+3.1.1.17	"L-ascorbate biosynthesis VI (engineered pathway)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Pentose phosphate pathway";"Sorbitol biosynthesis II";"Caprolactam degradation";"Ascorbate and aldarate metabolism"
APLA008535-PA	1	Reactome: R-HSA-8943724	"Regulation of PTEN gene transcription"
APLA009193-PA	6	Reactome: R-HSA-8951430;Reactome: R-HSA-4641265;Reactome: R-HSA-4411364;Reactome: R-HSA-3769402;Reactome: R-HSA-4086398;Reactome: R-HSA-201722	"RUNX3 regulates WNT signaling";"Repression of WNT target genes";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex";"Ca2+ pathway";"Formation of the beta-catenin:TCF transactivating complex"
APLA004822-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA000689-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA008485-PA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
APLA008833-PA	7	KEGG: 00860+6.1.1.17;KEGG: 00970+6.1.1.17;Reactome: R-HSA-6782315;KEGG: 00970+6.1.1.15;MetaCyc: PWY-5188;Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Porphyrin and chlorophyll metabolism";"Aminoacyl-tRNA biosynthesis";"tRNA modification in the nucleus and cytosol";"Aminoacyl-tRNA biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
APLA013595-PA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA001768-PA	2	Reactome: R-HSA-418594;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
APLA004277-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA014158-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA010425-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA004630-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA005788-PA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
APLA003561-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA007353-PA	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
APLA010862-PA	1	KEGG: 00970+6.1.1.22	"Aminoacyl-tRNA biosynthesis"
APLA007909-PA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
APLA000468-PA	42	KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-7094;KEGG: 00627+4.2.1.17;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;KEGG: 00640+4.2.1.17;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-7007;MetaCyc: PWY-7606;MetaCyc: PWY-7779;KEGG: 00360+4.2.1.17;MetaCyc: PWY-5789;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6583;MetaCyc: PWY-6945;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00410+4.2.1.17;MetaCyc: PWY-7726;KEGG: 00903+4.2.1.17;MetaCyc: PWY-7656;MetaCyc: PWY-7654;MetaCyc: PWY-6944;MetaCyc: PWY-5138;MetaCyc: PWY-6435;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-7401;MetaCyc: PWY-5109;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-6863;KEGG: 00592+4.2.1.17;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-6883;MetaCyc: PWY-7216;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00623+1.1.1.35;MetaCyc: PWY-5136;MetaCyc: PWY-1361;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177	"Fatty acid degradation";"Fatty acid salvage";"Aminobenzoate degradation";"Fatty acid elongation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Propanoate metabolism";"Butanoate metabolism";"Butanoate metabolism";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Methyl tert-butyl ether degradation";"Phenylalanine metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Lysine degradation";"Caprolactam degradation";"Pyruvate fermentation to butanol I";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Benzoate degradation";"beta-Alanine metabolism";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Limonene and pinene degradation";"Spodoptera littoralis pheromone biosynthesis";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Androstenedione degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"4-hydroxybenzoate biosynthesis III (plants)";"Valine, leucine and isoleucine degradation";"2-methylpropene degradation";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Fermentation to 2-methylbutanoate";"Geraniol degradation";"Pyruvate fermentation to hexanol (engineered)";"alpha-Linolenic acid metabolism";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to butanol II (engineered)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Tryptophan metabolism";"Toluene degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"Benzoyl-coa degradation I (aerobic)";"Fatty acid degradation";"Glutaryl-coa degradation"
APLA008553-PA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
APLA007667-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
APLA002582-PA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
APLA007925-PA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
APLA004579-PA	3	KEGG: 00600+3.2.1.45;Reactome: R-HSA-1660662;KEGG: 00511+3.2.1.45	"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Other glycan degradation"
APLA014501-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA004615-PA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
APLA010695-PA	2	Reactome: R-HSA-1362409;Reactome: R-HSA-1268020	"Mitochondrial iron-sulfur cluster biogenesis";"Mitochondrial protein import"
APLA007530-PA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
APLA013123-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA014155-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA002323-PA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
APLA013219-PA	6	MetaCyc: PWY-5789;MetaCyc: PWY-4381;Reactome: R-HSA-196780;MetaCyc: PWY-6722;MetaCyc: PWY-5743;MetaCyc: PWY-5744	"3-hydroxypropanoate/4-hydroxybutanate cycle";"Fatty acid biosynthesis initiation (bacteria and plants)";"Biotin transport and metabolism";"Candicidin biosynthesis";"3-hydroxypropanoate cycle";"Glyoxylate assimilation"
APLA005348-PA	7	Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-156711;Reactome: R-HSA-1362277;Reactome: R-HSA-1362300;Reactome: R-HSA-69656;Reactome: R-HSA-1538133	"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by DREAM complex";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin A:Cdk2-associated events at S phase entry";"G0 and Early G1"
APLA008807-PA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
APLA010733-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA011488-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA009925-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA010385-PA	3	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-425561	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Sodium/Calcium exchangers"
APLA002965-PA	5	KEGG: 00860+4.2.1.24;MetaCyc: PWY-5189;Reactome: R-HSA-189451;Reactome: R-HSA-6798695;MetaCyc: PWY-5188	"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis II (from glycine)";"Heme biosynthesis";"Neutrophil degranulation";"Tetrapyrrole biosynthesis I (from glutamate)"
APLA014679-PA	14	Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-165054;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-450520;Reactome: R-HSA-9634638;Reactome: R-HSA-2500257;Reactome: R-HSA-168333;Reactome: R-HSA-2173788;Reactome: R-HSA-68877;Reactome: R-HSA-3769402;Reactome: R-HSA-5687128;Reactome: R-HSA-69273	"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Rev-mediated nuclear export of HIV RNA";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"HuR (ELAVL1) binds and stabilizes mRNA";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Resolution of Sister Chromatid Cohesion";"NEP/NS2 Interacts with the Cellular Export Machinery";"Downregulation of TGF-beta receptor signaling";"Mitotic Prometaphase";"Deactivation of the beta-catenin transactivating complex";"MAPK6/MAPK4 signaling";"Cyclin A/B1/B2 associated events during G2/M transition"
APLA009217-PA	6	Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-389957;Reactome: R-HSA-5620922	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Prefoldin mediated transfer of substrate to CCT/TriC";"BBSome-mediated cargo-targeting to cilium"
APLA010457-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA006696-PA	2	Reactome: R-HSA-446193;Reactome: R-HSA-4549349	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG2 causes ALG2-CDG (CDG-1i)"
APLA000028-PA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
APLA000829-PA	3	Reactome: R-HSA-5689603;Reactome: R-HSA-3214847;Reactome: R-HSA-5696394	"UCH proteinases";"HATs acetylate histones";"DNA Damage Recognition in GG-NER"
APLA003966-PA	2	Reactome: R-HSA-5694530;Reactome: R-HSA-204005	"Cargo concentration in the ER";"COPII-mediated vesicle transport"
APLA001661-PA	3	Reactome: R-HSA-5696395;Reactome: R-HSA-5696394;Reactome: R-HSA-3108214	"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER";"SUMOylation of DNA damage response and repair proteins"
APLA001074-PA	1	Reactome: R-HSA-77108	"Utilization of Ketone Bodies"
APLA000668-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA012291-PA	4	Reactome: R-HSA-8856828;Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-5663213	"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs"
APLA005169-PA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
APLA005274-PA	3	Reactome: R-HSA-416476;Reactome: R-HSA-418594;Reactome: R-HSA-375276	"G alpha (q) signalling events";"G alpha (i) signalling events";"Peptide ligand-binding receptors"
APLA010400-PA	3	Reactome: R-HSA-2514859;MetaCyc: PWY-7799;MetaCyc: PWY-7800	"Inactivation, recovery and regulation of the phototransduction cascade";"Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway"
APLA003793-PA	1	Reactome: R-HSA-5689603	"UCH proteinases"
APLA004699-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA003842-PA	40	Reactome: R-HSA-75955;Reactome: R-HSA-5601884;Reactome: R-HSA-77075;Reactome: R-HSA-6782135;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167160;Reactome: R-HSA-203927;Reactome: R-HSA-8851708;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-72163;Reactome: R-HSA-73776;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-5578749;Reactome: R-HSA-75953;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-6782210;Reactome: R-HSA-72165;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648;Reactome: R-HSA-5617472;Reactome: R-HSA-6781827;Reactome: R-HSA-167238;Reactome: R-HSA-9018519;Reactome: R-HSA-167242	"RNA Polymerase II Transcription Elongation";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Dual incision in TC-NER";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"MicroRNA (miRNA) biogenesis";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"mRNA Splicing - Major Pathway";"RNA Polymerase II Promoter Escape";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Transcriptional regulation by small RNAs";"RNA Polymerase II Transcription Initiation";"Formation of the Early Elongation Complex";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Minor Pathway";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Pausing and recovery of Tat-mediated HIV elongation";"Estrogen-dependent gene expression";"Abortive elongation of HIV-1 transcript in the absence of Tat"
APLA002237-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA015057-PA	5	Reactome: R-HSA-5658442;Reactome: R-HSA-8849471;Reactome: R-HSA-5218921;Reactome: R-HSA-186763;Reactome: R-HSA-3928662	"Regulation of RAS by GAPs";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases";"VEGFR2 mediated cell proliferation";"Downstream signal transduction";"EPHB-mediated forward signaling"
APLA009585-PA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
APLA005078-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA002988-PA	10	Reactome: R-HSA-9617324;Reactome: R-HSA-447038;Reactome: R-HSA-8849932;Reactome: R-HSA-5673001;Reactome: R-HSA-399719;Reactome: R-HSA-442982;Reactome: R-HSA-451308;Reactome: R-HSA-9609736;Reactome: R-HSA-438066;Reactome: R-HSA-9620244	"Negative regulation of NMDA receptor-mediated neuronal transmission";"NrCAM interactions";"Synaptic adhesion-like molecules";"RAF/MAP kinase cascade";"Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Activation of Ca-permeable Kainate Receptor";"Assembly and cell surface presentation of NMDA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"Long-term potentiation"
APLA008497-PA	7	Reactome: R-HSA-2691232;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2979096;MetaCyc: PWY-7511	"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination"
APLA010653-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA014427-PA	3	KEGG: 00051+1.1.1.271;KEGG: 00520+1.1.1.271;Reactome: R-HSA-6787639	"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"GDP-fucose biosynthesis"
APLA012986-PA	13	Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-72689	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits"
APLA008273-PA	4	MetaCyc: PWY-5188;KEGG: 00860+2.5.1.61;MetaCyc: PWY-5189;Reactome: R-HSA-189451	"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis II (from glycine)";"Heme biosynthesis"
APLA002364-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-8869496	"rRNA modification in the nucleus and cytosol";"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"
APLA005946-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA011095-PA	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
APLA002294-PA	16	Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-2408557	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Selenocysteine synthesis"
APLA003860-PA	5	Reactome: R-HSA-196757;KEGG: 00670+1.5.1.20;MetaCyc: PWY-3841;MetaCyc: PWY-2201;KEGG: 00720+1.5.1.20	"Metabolism of folate and pterines";"One carbon pool by folate";"Folate transformations II (plants)";"Folate transformations I";"Carbon fixation pathways in prokaryotes"
APLA009772-PA	3	Reactome: R-HSA-162658;Reactome: R-HSA-204005;Reactome: R-HSA-6807878	"Golgi Cisternae Pericentriolar Stack Reorganization";"COPII-mediated vesicle transport";"COPI-mediated anterograde transport"
APLA008939-PA	5	Reactome: R-HSA-211976;Reactome: R-HSA-196108;Reactome: R-HSA-2395516;Reactome: R-HSA-1362409;Reactome: R-HSA-5579026	"Endogenous sterols";"Pregnenolone biosynthesis";"Electron transport from NADPH to Ferredoxin";"Mitochondrial iron-sulfur cluster biogenesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"
APLA013385-PA	9	Reactome: R-HSA-3371599;MetaCyc: PWY-6142;KEGG: 00720+6.4.1.1;MetaCyc: PWY-8086;Reactome: R-HSA-70263;MetaCyc: PWY-6146;KEGG: 00020+6.4.1.1;Reactome: R-HSA-196780;KEGG: 00620+6.4.1.1	"Defective HLCS causes multiple carboxylase deficiency";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Carbon fixation pathways in prokaryotes";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis";"Methanobacterium thermoautotrophicum biosynthetic metabolism";"Citrate cycle (TCA cycle)";"Biotin transport and metabolism";"Pyruvate metabolism"
APLA006357-PA	5	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
APLA008948-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA000105-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA015416-PA	26	Reactome: R-HSA-389977;Reactome: R-HSA-5663220;Reactome: R-HSA-8852276;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-437239;Reactome: R-HSA-8955332;Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-380320;Reactome: R-HSA-2132295;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-3371497;Reactome: R-HSA-9609736;Reactome: R-HSA-389960;Reactome: R-HSA-190861;Reactome: R-HSA-9609690	"Post-chaperonin tubulin folding pathway";"RHO GTPases Activate Formins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Carboxyterminal post-translational modifications of tubulin";"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Recruitment of NuMA to mitotic centrosomes";"MHC class II antigen presentation";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"Cilium Assembly";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Assembly and cell surface presentation of NMDA receptors";"Formation of tubulin folding intermediates by CCT/TriC";"Gap junction assembly";"HCMV Early Events"
APLA012983-PA	18	MetaCyc: PWY-7383;KEGG: 00360+2.6.1.1;KEGG: 00710+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00330+2.6.1.1;MetaCyc: PWY-6638;KEGG: 00960+2.6.1.1;KEGG: 00250+2.6.1.1;MetaCyc: PWY-7115;KEGG: 00270+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00950+2.6.1.1;MetaCyc: PWY-5913;MetaCyc: PWY-7117;KEGG: 00401+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00220+2.6.1.1;MetaCyc: PWY-6642	"Anaerobic energy metabolism (invertebrates, cytosol)";"Phenylalanine metabolism";"Carbon fixation in photosynthetic organisms";"Coenzyme M biosynthesis II";"Arginine and proline metabolism";"Sulfolactate degradation III";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Alanine, aspartate and glutamate metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Cysteine and methionine metabolism";"Tyrosine metabolism";"Isoquinoline alkaloid biosynthesis";"Partial TCA cycle (obligate autotrophs)";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Novobiocin biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine biosynthesis";"(R)-cysteate degradation"
APLA000217-PA	6	Reactome: R-HSA-446210;KEGG: 00052+3.5.1.25;MetaCyc: PWY-7395;MetaCyc: PWY-7077;MetaCyc: PWY-6906;KEGG: 00520+3.5.1.25	"Synthesis of UDP-N-acetyl-glucosamine";"Galactose metabolism";"D-galactosamine and N-acetyl-D-galactosamine degradation";"N-acetyl-D-galactosamine degradation";"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism"
APLA014771-PA	1	Reactome: R-HSA-5689603	"UCH proteinases"
APLA006990-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA013750-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA014973-PA	2	Reactome: R-HSA-2032785;Reactome: R-HSA-8951671	"YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription"
APLA002790-PA	14	Reactome: R-HSA-6782210;Reactome: R-HSA-5696397;Reactome: R-HSA-5656121;Reactome: R-HSA-69091;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-5655862;Reactome: R-HSA-5651801;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-174411;Reactome: R-HSA-110312	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLI";"Polymerase switching";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLK";"PCNA-Dependent Long Patch Base Excision Repair";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1"
APLA012845-PA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
APLA003228-PA	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
APLA013811-PA	4	MetaCyc: PWY-2781;Reactome: R-HSA-6787450;Reactome: R-HSA-6782315;KEGG: 00908+2.5.1.75	"Cis-zeatin biosynthesis";"tRNA modification in the mitochondrion";"tRNA modification in the nucleus and cytosol";"Zeatin biosynthesis"
APLA015396-PA	4	MetaCyc: PWY-7822;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902	"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)"
APLA010110-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA001872-PA	2	Reactome: R-HSA-5689880;Reactome: R-HSA-110320	"Ub-specific processing proteases";"Translesion Synthesis by POLH"
APLA004173-PA	6	KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241;Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;Reactome: R-HSA-6798695;KEGG: 00380+1.11.1.6	"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import";"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Neutrophil degranulation";"Tryptophan metabolism"
APLA000593-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA013122-PA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.20	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
APLA011394-PA	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
APLA004209-PA	2	Reactome: R-HSA-2564830;Reactome: R-HSA-5693554	"Cytosolic iron-sulfur cluster assembly";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
APLA005749-PA	18	Reactome: R-HSA-1482925;Reactome: R-HSA-1482801;Reactome: R-HSA-1482922;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-6803;MetaCyc: PWY-7417;MetaCyc: PWY-7783;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-8051;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482839	"Acyl chain remodelling of PG";"Acyl chain remodelling of PS";"Acyl chain remodelling of PI";"Synthesis of PA";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidate, yeast)";"Plasmalogen degradation";"Acyl chain remodelling of PC";"Ether lipid metabolism";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Arachidonic acid metabolism";"Acyl chain remodelling of PE"
APLA010884-PA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
APLA011746-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA012152-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA014028-PA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
APLA014283-PA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
APLA008781-PA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-1268020	"Cristae formation";"Mitochondrial protein import"
APLA004293-PA	10	MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-5826;MetaCyc: PWY-4061;MetaCyc: PWY-7112;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-7559;MetaCyc: PWY-6842;KEGG: 00460+2.3.2.2	"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Gamma-glutamyl cycle";"Hypoglycin biosynthesis";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Glutathione metabolism";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II";"Cyanoamino acid metabolism"
APLA000024-PA	2	KEGG: 00052+3.2.1.26;KEGG: 00500+3.2.1.26	"Galactose metabolism";"Starch and sucrose metabolism"
APLA006361-PA	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
APLA005829-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA001207-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA009660-PA	6	Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444	"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
APLA003608-PA	5	Reactome: R-HSA-162588;Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-9615710;Reactome: R-HSA-917729	"Budding and maturation of HIV virion";"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)"
APLA014384-PA	13	Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
APLA007919-PA	14	KEGG: 00680+4.2.1.11;MetaCyc: PWY-8004;MetaCyc: PWY-7003;MetaCyc: PWY-5723;MetaCyc: PWY-1622;KEGG: 00010+4.2.1.11;MetaCyc: PWY-2221;MetaCyc: PWY-6886;MetaCyc: PWY-5484;MetaCyc: PWY-6901;MetaCyc: PWY-7124;MetaCyc: PWY-6142;MetaCyc: PWY-1042;MetaCyc: PWY-7218	"Methane metabolism";"Entner-Doudoroff pathway I";"Glycerol degradation to butanol";"Rubisco shunt";"Formaldehyde assimilation I (serine pathway)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Superpathway of glucose and xylose degradation";"Ethylene biosynthesis V (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)"
APLA012600-PA	2	Reactome: R-HSA-977225;Reactome: R-HSA-8854214	"Amyloid fiber formation";"TBC/RABGAPs"
APLA005695-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA011706-PA	57	Reactome: R-HSA-180534;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-1236974;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5678895;Reactome: R-HSA-6798695;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258	"Vpu mediated degradation of CD4";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"ER-Phagosome pathway";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Neddylation";"Separation of Sister Chromatids";"Defective CFTR causes cystic fibrosis";"Neutrophil degranulation";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"UCH proteinases";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL"
APLA004257-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA011224-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA002403-PA	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
APLA000151-PA	2	KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20	"Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism"
APLA003696-PA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA010141-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA002533-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA009991-PA	3	MetaCyc: PWY-6987;KEGG: 00785+2.3.1.181;MetaCyc: PWY-7382	"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation IV (yeast)"
APLA001288-PA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
APLA008007-PA	3	KEGG: 00790+4.1.99.22;MetaCyc: PWY-6823;Reactome: R-HSA-947581	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
APLA004196-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA012166-PA	5	Reactome: R-HSA-1234158;Reactome: R-HSA-1234176;Reactome: R-HSA-8849473;Reactome: R-HSA-1234174;Reactome: R-HSA-8951664	"Regulation of gene expression by Hypoxia-inducible Factor";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"PTK6 Expression";"Cellular response to hypoxia";"Neddylation"
APLA003471-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA006452-PA	4	Reactome: R-HSA-162699;Reactome: R-HSA-4717374;Reactome: R-HSA-4719377;Reactome: R-HSA-4719360	"Synthesis of dolichyl-phosphate mannose";"Defective DPM1 causes DPM1-CDG (CDG-1e)";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM3 causes DPM3-CDG (CDG-1o)"
APLA000426-PA	36	Reactome: R-HSA-68877;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-5419276;Reactome: R-HSA-3301854;Reactome: R-HSA-4570464;Reactome: R-HSA-9648025;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-5368286;Reactome: R-HSA-6784531;Reactome: R-HSA-159227;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-165054;Reactome: R-HSA-141444;Reactome: R-HSA-168271;Reactome: R-HSA-4551638;Reactome: R-HSA-159231;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-5619107;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-5389840	"Mitotic Prometaphase";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"Mitochondrial translation termination";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of RNA binding proteins";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"Mitochondrial translation initiation";"tRNA processing in the nucleus";"Transport of the SLBP independent Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"Rev-mediated nuclear export of HIV RNA";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitochondrial translation elongation"
APLA002126-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA013769-PA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
APLA002484-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA004808-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA009834-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA004181-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA004276-PA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA008746-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA003750-PA	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
APLA011491-PA	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
APLA012117-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA004622-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA004858-PA	1	Reactome: R-HSA-400253	"Circadian Clock"
APLA008182-PA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA004705-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA006026-PA	13	Reactome: R-HSA-2160916;KEGG: 00520+3.2.1.52;MetaCyc: PWY-7883;KEGG: 00531+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-1660662;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;KEGG: 00511+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00604+3.2.1.52;MetaCyc: PWY-6902	"Hyaluronan uptake and degradation";"Amino sugar and nucleotide sugar metabolism";"Anhydromuropeptides recycling II";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Various types of N-glycan biosynthesis";"Glycosphingolipid metabolism";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Other glycan degradation";"CS/DS degradation";"Glycosphingolipid biosynthesis - ganglio series";"Chitin degradation II (Vibrio)"
APLA001234-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA007345-PA	1	Reactome: R-HSA-211981	"Xenobiotics"
APLA004376-PA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
APLA009762-PA	2	MetaCyc: PWY-5905;Reactome: R-HSA-204626	"Hypusine biosynthesis";"Hypusine synthesis from eIF5A-lysine"
APLA008598-PA	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
APLA005811-PA	12	MetaCyc: PWY-6121;Reactome: R-HSA-73817;KEGG: 00230+6.3.3.1;MetaCyc: PWY-6613;KEGG: 00230+2.1.2.2;MetaCyc: PWY-6122;KEGG: 00970+2.1.2.9;MetaCyc: PWY-6277;KEGG: 00670+2.1.2.9;KEGG: 00670+2.1.2.2;KEGG: 00230+6.3.4.13;Reactome: R-HSA-196780	"5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis II";"Aminoacyl-tRNA biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"One carbon pool by folate";"One carbon pool by folate";"Purine metabolism";"Biotin transport and metabolism"
APLA004210-PA	3	Reactome: R-HSA-480985;KEGG: 00510+2.4.1.117;Reactome: R-HSA-913709	"Synthesis of dolichyl-phosphate-glucose";"N-Glycan biosynthesis";"O-linked glycosylation of mucins"
APLA010574-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA015161-PA	1	Reactome: R-HSA-193648	"NRAGE signals death through JNK"
APLA008135-PA	13	MetaCyc: PWY-7857;MetaCyc: PWY-5133;Reactome: R-HSA-71384;MetaCyc: PWY-6672;KEGG: 00630+6.2.1.1;KEGG: 00620+6.2.1.1;KEGG: 00720+6.2.1.1;MetaCyc: PWY-5132;KEGG: 00680+6.2.1.1;KEGG: 00640+6.2.1.1;KEGG: 00010+6.2.1.1;MetaCyc: PWY-7118;MetaCyc: PWY-5108	"Adlupulone and adhumulone biosynthesis";"Colupulone and cohumulone biosynthesis";"Ethanol oxidation";"Cis-genanyl-coa degradation";"Glyoxylate and dicarboxylate metabolism";"Pyruvate metabolism";"Carbon fixation pathways in prokaryotes";"Lupulone and humulone biosynthesis";"Methane metabolism";"Propanoate metabolism";"Glycolysis / Gluconeogenesis";"Chitin degradation to ethanol";"L-isoleucine biosynthesis V"
APLA004746-PA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
APLA015425-PA	1	Reactome: R-HSA-196741	"Cobalamin (Cbl, vitamin B12) transport and metabolism"
APLA007416-PA	11	Reactome: R-HSA-163615;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418594;Reactome: R-HSA-170670;Reactome: R-HSA-164378;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-432040;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-5610787	"PKA activation";"Purine metabolism";"G alpha (i) signalling events";"Adenylate cyclase inhibitory pathway";"PKA activation in glucagon signalling";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"Hedgehog 'off' state"
APLA004800-PA	2	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
APLA009052-PA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
APLA012002-PA	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
APLA005349-PA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA008533-PA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
APLA001202-PA	8	KEGG: 00240+2.7.4.9;MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7198;MetaCyc: PWY-7197;MetaCyc: PWY-7187	"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis II"
APLA009847-PA	4	Reactome: R-HSA-422085;Reactome: R-HSA-1799339;Reactome: R-HSA-381771;Reactome: R-HSA-400511	"Synthesis, secretion, and deacylation of Ghrelin";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"
APLA005035-PA	1	Reactome: R-HSA-191273	"Cholesterol biosynthesis"
APLA014528-PA	2	Reactome: R-HSA-70895;KEGG: 00280+1.1.1.31	"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation"
APLA003076-PA	5	Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-72187	"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing"
APLA013705-PA	10	MetaCyc: PWY-5484;MetaCyc: PWY-1861;KEGG: 00052+2.7.1.11;MetaCyc: PWY-1042;KEGG: 00680+2.7.1.11;KEGG: 00030+2.7.1.11;KEGG: 00010+2.7.1.11;KEGG: 00051+2.7.1.11;Reactome: R-HSA-70171;MetaCyc: PWY-7385	"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Galactose metabolism";"Glycolysis IV (plant cytosol)";"Methane metabolism";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Glycolysis";"1,3-propanediol biosynthesis (engineered)"
APLA007523-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA000126-PA	56	Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-4641257;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-8939902;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8852276;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-180585;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-1236974;Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-69017;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-5610780;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178	"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of AXIN";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of RUNX2 expression and activity";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vif-mediated degradation of APOBEC3G";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway";"Defective CFTR causes cystic fibrosis";"Neddylation";"Separation of Sister Chromatids";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"CDK-mediated phosphorylation and removal of Cdc6";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"Degradation of GLI1 by the proteasome";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
APLA014822-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA010376-PA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-71403	"Mitochondrial protein import";"Citric acid cycle (TCA cycle)"
APLA002555-PA	19	Reactome: R-HSA-8963888;Reactome: R-HSA-3000480;Reactome: R-HSA-8957275;Reactome: R-HSA-3000484;Reactome: R-HSA-5686938;Reactome: R-HSA-8856828;Reactome: R-HSA-432142;Reactome: R-HSA-8964038;Reactome: R-HSA-381426;Reactome: R-HSA-8964041;Reactome: R-HSA-202733;Reactome: R-HSA-3000497;Reactome: R-HSA-8866423;Reactome: R-HSA-8963901;Reactome: R-HSA-8856825;Reactome: R-HSA-8964026;Reactome: R-HSA-3000471;Reactome: R-HSA-8964046;Reactome: R-HSA-975634	"Chylomicron assembly";"Scavenging by Class A Receptors";"Post-translational protein phosphorylation";"Scavenging by Class F Receptors";"Regulation of TLR by endogenous ligand";"Clathrin-mediated endocytosis";"Platelet sensitization by LDL";"LDL clearance";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"LDL remodeling";"Cell surface interactions at the vascular wall";"Scavenging by Class H Receptors";"VLDL assembly";"Chylomicron remodeling";"Cargo recognition for clathrin-mediated endocytosis";"Chylomicron clearance";"Scavenging by Class B Receptors";"VLDL clearance";"Retinoid metabolism and transport"
APLA006773-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA003039-PA	11	Reactome: R-HSA-163615;Reactome: R-HSA-170670;Reactome: R-HSA-170660;Reactome: R-HSA-164378;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-432040;Reactome: R-HSA-5610787;Reactome: R-HSA-418555;Reactome: R-HSA-163359	"PKA activation";"Adenylate cyclase inhibitory pathway";"Adenylate cyclase activating pathway";"PKA activation in glucagon signalling";"Purine metabolism";"G alpha (i) signalling events";"G alpha (z) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation"
APLA011917-PA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
APLA006359-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA011159-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA013082-PA	2	Reactome: R-HSA-2151201;KEGG: 00760+2.3.1.286	"Transcriptional activation of mitochondrial biogenesis";"Nicotinate and nicotinamide metabolism"
APLA005196-PA	6	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex"
APLA008693-PA	3	Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-381038	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"XBP1(S) activates chaperone genes"
APLA013359-PA	26	Reactome: R-HSA-983189;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-9619483;Reactome: R-HSA-5617833;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-389960;Reactome: R-HSA-389977;Reactome: R-HSA-5663220;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-437239;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-8955332;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-6811434	"Kinesins";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"Activation of AMPK downstream of NMDARs";"Cilium Assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Gap junction assembly";"HCMV Early Events";"Formation of tubulin folding intermediates by CCT/TriC";"Post-chaperonin tubulin folding pathway";"RHO GTPases Activate Formins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Separation of Sister Chromatids";"Aggrephagy";"Carboxyterminal post-translational modifications of tubulin";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA002426-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA013765-PA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
APLA000238-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA014459-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA000921-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA009433-PA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA010573-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA010503-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA002849-PA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
APLA002548-PA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
APLA007861-PA	2	Reactome: R-HSA-8873719;Reactome: R-HSA-8876198	"RAB geranylgeranylation";"RAB GEFs exchange GTP for GDP on RABs"
APLA002573-PA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA000258-PA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
APLA011586-PA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
APLA013924-PA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
APLA002544-PA	6	MetaCyc: PWY-6987;Reactome: R-HSA-196780;KEGG: 00780+6.3.4.15;Reactome: R-HSA-3371599;KEGG: 00785+2.3.1.181;MetaCyc: PWY-7382	"Lipoate biosynthesis and incorporation III (Bacillus)";"Biotin transport and metabolism";"Biotin metabolism";"Defective HLCS causes multiple carboxylase deficiency";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation IV (yeast)"
APLA001309-PA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
APLA009117-PA	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
APLA011765-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA010815-PA	3	KEGG: 00860+1.16.3.1;Reactome: R-HSA-1268020;Reactome: R-HSA-1362409	"Porphyrin and chlorophyll metabolism";"Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis"
APLA007878-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA012027-PA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
APLA010588-PA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
APLA000549-PA	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
APLA001933-PA	6	MetaCyc: PWY-7765;Reactome: R-HSA-71240;KEGG: 00380+1.14.13.9;MetaCyc: PWY-7717;MetaCyc: PWY-6309;MetaCyc: PWY-5651	"3-hydroxy-4-methyl-anthranilate biosynthesis II";"Tryptophan catabolism";"Tryptophan metabolism";"3-hydroxy-4-methyl-anthranilate biosynthesis I";"L-tryptophan degradation XI (mammalian, via kynurenine)";"L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde"
APLA005503-PA	6	MetaCyc: PWY-7356;MetaCyc: PWY-6907;KEGG: 00730+2.7.6.2;MetaCyc: PWY-6898;Reactome: R-HSA-196819;MetaCyc: PWY-6908	"Thiamine salvage IV (yeast)";"Thiamine diphosphate biosynthesis III (Staphylococcus)";"Thiamine metabolism";"Thiamine salvage III";"Vitamin B1 (thiamin) metabolism";"Thiamine diphosphate biosynthesis IV (eukaryotes)"
APLA003246-PA	3	Reactome: R-HSA-2022928;KEGG: 00534+5.1.3.17;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Heparan sulfate biosynthesis (late stages)"
APLA006961-PA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
APLA004183-PA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6	"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism"
APLA002704-PA	4	Reactome: R-HSA-73621;KEGG: 00250+1.4.1.14;KEGG: 00910+1.4.1.14;MetaCyc: PWY-6963	"Pyrimidine catabolism";"Alanine, aspartate and glutamate metabolism";"Nitrogen metabolism";"Ammonia assimilation cycle I"
APLA001292-PA	7	Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-373753;Reactome: R-HSA-6798695;Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-264870	"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"Nephrin family interactions";"Neutrophil degranulation";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Caspase-mediated cleavage of cytoskeletal proteins"
APLA003474-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA008595-PA	1	Reactome: R-HSA-196757	"Metabolism of folate and pterines"
APLA002343-PA	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
APLA001711-PA	3	MetaCyc: PWY-5129;Reactome: R-HSA-1660661;KEGG: 00600+1.14.19.17	"Sphingolipid biosynthesis (plants)";"Sphingolipid de novo biosynthesis";"Sphingolipid metabolism"
APLA002333-PA	11	Reactome: R-HSA-8851680;Reactome: R-HSA-74259;MetaCyc: PWY-6607;MetaCyc: PWY-6596;MetaCyc: PWY-6608;MetaCyc: PWY-5497;KEGG: 00230+1.17.1.4;MetaCyc: PWY-5695;MetaCyc: PWY-6999;MetaCyc: PWY-6606;MetaCyc: PWY-6538	"Butyrophilin (BTN) family interactions";"Purine catabolism";"Guanosine nucleotides degradation I";"Adenosine nucleotides degradation I";"Guanosine nucleotides degradation III";"Purine nucleobases degradation II (anaerobic)";"Purine metabolism";"Inosine 5'-phosphate degradation";"Theophylline degradation";"Guanosine nucleotides degradation II";"Caffeine degradation III (bacteria, via demethylation)"
APLA015308-PA	2	Reactome: R-HSA-70171;Reactome: R-HSA-70263	"Glycolysis";"Gluconeogenesis"
APLA002864-PA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.1	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
APLA008243-PA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
APLA003382-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA008027-PA	14	KEGG: 00561+2.3.1.51;Reactome: R-HSA-1483166;MetaCyc: PWY-8053;MetaCyc: PWY-7587;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-5981;MetaCyc: PWY-8055;MetaCyc: PWY-7417;MetaCyc: PWY-5667;MetaCyc: PWY-7411;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-7782	"Glycerolipid metabolism";"Synthesis of PA";"Anandamide biosynthesis II";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Palmitoyl ethanolamide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Plasmalogen biosynthesis"
APLA013222-PA	5	MetaCyc: PWY-7268;MetaCyc: PWY-7269;Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23;MetaCyc: PWY-5083	"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD/NADH phosphorylation and dephosphorylation"
APLA001827-PA	1	Reactome: R-HSA-8851805	"MET activates RAS signaling"
APLA013198-PA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA008956-PA	11	Reactome: R-HSA-2173796;Reactome: R-HSA-9013695;Reactome: R-HSA-9013508;Reactome: R-HSA-72163;Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-2644606;Reactome: R-HSA-210744;Reactome: R-HSA-8941856;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862	"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH3 Intracellular Domain Regulates Transcription";"mRNA Splicing - Major Pathway";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"RUNX3 regulates NOTCH signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
APLA010731-PA	4	Reactome: R-HSA-167160;Reactome: R-HSA-77075;Reactome: R-HSA-72086;MetaCyc: PWY-7375	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping";"Mrna capping I"
APLA013161-PA	7	Reactome: R-HSA-174403;MetaCyc: PWY-6840;Reactome: R-HSA-5578999;KEGG: 00480+6.3.2.2;MetaCyc: PWY-8043;KEGG: 00270+6.3.2.2;MetaCyc: PWY-7255	"Glutathione synthesis and recycling";"Homoglutathione biosynthesis";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Glutathione metabolism";"Ophthalmate biosynthesis";"Cysteine and methionine metabolism";"Ergothioneine biosynthesis I (bacteria)"
APLA004714-PA	4	Reactome: R-HSA-5625970;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-983189	"RHO GTPases activate KTN1";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Kinesins"
APLA002412-PA	1	Reactome: R-HSA-427652	"Sodium-coupled phosphate cotransporters"
APLA006562-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA010582-PA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
APLA000565-PA	12	KEGG: 00010+4.1.2.13;KEGG: 00710+4.1.2.13;Reactome: R-HSA-70171;MetaCyc: PWY-7385;Reactome: R-HSA-70263;KEGG: 00030+4.1.2.13;KEGG: 00680+4.1.2.13;MetaCyc: PWY-1861;MetaCyc: PWY-5484;KEGG: 00051+4.1.2.13;MetaCyc: PWY-1042;MetaCyc: PWY-6142	"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Glycolysis";"1,3-propanediol biosynthesis (engineered)";"Gluconeogenesis";"Pentose phosphate pathway";"Methane metabolism";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Fructose and mannose metabolism";"Glycolysis IV (plant cytosol)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
APLA005048-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA011526-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA003527-PA	4	Reactome: R-HSA-1632852;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-1660499	"Macroautophagy";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Synthesis of PIPs at the plasma membrane"
APLA002667-PA	10	MetaCyc: PWY-6453;MetaCyc: PWY-8055;MetaCyc: PWY-5667;MetaCyc: PWY-7411;KEGG: 00561+2.3.1.15;MetaCyc: PWY-7587;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.15;MetaCyc: PWY-8053;Reactome: R-HSA-1483166	"Stigma estolide biosynthesis";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Glycerolipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Anandamide biosynthesis II";"Synthesis of PA"
APLA003026-PA	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
APLA002820-PA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.9	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
APLA013754-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA001897-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA003300-PA	2	Reactome: R-HSA-416482;Reactome: R-HSA-456926	"G alpha (12/13) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)"
APLA005551-PA	6	Reactome: R-HSA-5673001;Reactome: R-HSA-9028731;Reactome: R-HSA-5654712;Reactome: R-HSA-5654693;Reactome: R-HSA-5654700;Reactome: R-HSA-5654706	"RAF/MAP kinase cascade";"Activated NTRK2 signals through FRS2 and FRS3";"FRS-mediated FGFR4 signaling";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR2 signaling";"FRS-mediated FGFR3 signaling"
APLA001717-PA	5	Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-159231;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA Derived from an Intronless Transcript";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
APLA009759-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA012978-PA	2	Reactome: R-HSA-1799339;Reactome: R-HSA-446203	"SRP-dependent cotranslational protein targeting to membrane";"Asparagine N-linked glycosylation"
APLA010422-PA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
APLA006649-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA005637-PA	3	Reactome: R-HSA-1236974;Reactome: R-HSA-9609523;Reactome: R-HSA-1799339	"ER-Phagosome pathway";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"SRP-dependent cotranslational protein targeting to membrane"
APLA004354-PA	3	KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00250+3.5.1.1	"Cyanoamino acid metabolism";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism"
APLA001524-PA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
APLA003279-PA	29	Reactome: R-HSA-167158;Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-73863;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-76042;Reactome: R-HSA-73762;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-75955;Reactome: R-HSA-6782210;Reactome: R-HSA-5696395;Reactome: R-HSA-167246;Reactome: R-HSA-6782135;Reactome: R-HSA-167160;Reactome: R-HSA-73772;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-5696400;Reactome: R-HSA-6781827;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-73776	"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Transcription Termination";"mRNA Capping";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of Incision Complex in GG-NER";"Tat-mediated elongation of the HIV-1 transcript";"Dual incision in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Dual Incision in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape"
APLA005113-PA	7	Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-73780	"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Chain Elongation"
APLA001949-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA008015-PA	2	Reactome: R-HSA-9010553;Reactome: R-HSA-975957	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA000344-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA008950-PA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
APLA001596-PA	33	Reactome: R-HSA-73762;Reactome: R-HSA-69273;Reactome: R-HSA-5696395;Reactome: R-HSA-6782210;Reactome: R-HSA-8939236;Reactome: R-HSA-6796648;Reactome: R-HSA-73772;Reactome: R-HSA-69202;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-427413;Reactome: R-HSA-77075;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-69231;Reactome: R-HSA-6782135;Reactome: R-HSA-69656;Reactome: R-HSA-112382;Reactome: R-HSA-167160;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-73776	"RNA Polymerase I Transcription Initiation";"Cyclin A/B1/B2 associated events during G2/M transition";"Formation of Incision Complex in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Promoter Escape";"Cyclin E associated events during G1/S transition";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the Early Elongation Complex";"mRNA Capping";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"NoRC negatively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Cyclin D associated events in G1";"Dual incision in TC-NER";"Cyclin A:Cdk2-associated events at S phase entry";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape"
APLA012163-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA011215-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA006275-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA005231-PA	27	Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-170822;Reactome: R-HSA-5619107;Reactome: R-HSA-4615885;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-3232142;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-3301854;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-6784531;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-159227;Reactome: R-HSA-4085377	"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of DNA replication proteins";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of ubiquitinylation proteins";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"tRNA processing in the nucleus";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP independent Mature mRNA";"SUMOylation of SUMOylation proteins"
APLA006619-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA010066-PA	14	MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199	"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation"
APLA006924-PA	14	Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167242;Reactome: R-HSA-167290;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167238;Reactome: R-HSA-167200;Reactome: R-HSA-167246	"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of HIV elongation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript"
APLA010065-PA	14	MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619	"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis"
APLA007822-PA	5	Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-5693571;Reactome: R-HSA-5689901;Reactome: R-HSA-5693565	"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Nonhomologous End-Joining (NHEJ)";"Metalloprotease DUBs";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
APLA000560-PA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
APLA014978-PA	2	MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis"
APLA011310-PA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
APLA003348-PA	8	Reactome: R-HSA-163615;Reactome: R-HSA-180024;Reactome: R-HSA-983231;Reactome: R-HSA-442720;Reactome: R-HSA-164378;Reactome: R-HSA-381676;Reactome: R-HSA-432040;Reactome: R-HSA-5610787	"PKA activation";"DARPP-32 events";"Factors involved in megakaryocyte development and platelet production";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"PKA activation in glucagon signalling";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state"
APLA005667-PA	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
APLA013125-PA	9	KEGG: 00400+2.6.1.5;Reactome: R-HSA-8963684;KEGG: 00401+2.6.1.5;KEGG: 00130+2.6.1.5;KEGG: 00350+2.6.1.5;KEGG: 00360+2.6.1.5;KEGG: 00950+2.6.1.5;KEGG: 00270+2.6.1.5;KEGG: 00960+2.6.1.5	"Phenylalanine, tyrosine and tryptophan biosynthesis";"Tyrosine catabolism";"Novobiocin biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Tyrosine metabolism";"Phenylalanine metabolism";"Isoquinoline alkaloid biosynthesis";"Cysteine and methionine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis"
APLA007350-PA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
APLA013813-PA	6	Reactome: R-HSA-6782135;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-6798695	"Dual incision in TC-NER";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Neutrophil degranulation"
APLA012887-PA	5	Reactome: R-HSA-1834949;Reactome: R-HSA-5693571;Reactome: R-HSA-3270619;Reactome: R-HSA-164843;Reactome: R-HSA-6798695	"Cytosolic sensors of pathogen-associated DNA";"Nonhomologous End-Joining (NHEJ)";"IRF3-mediated induction of type I IFN";"2-LTR circle formation";"Neutrophil degranulation"
APLA007636-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA014434-PA	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
APLA005384-PA	16	Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis"
APLA010555-PA	9	MetaCyc: PWY-6902;KEGG: 00604+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-7883;KEGG: 00603+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52	"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism"
APLA011278-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA002479-PA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
APLA001595-PA	14	MetaCyc: PWY-8052;KEGG: 00561+3.1.3.4;MetaCyc: PWY-8053;KEGG: 00565+3.1.3.4;MetaCyc: PWY-8051;Reactome: R-HSA-75109;MetaCyc: PWY-8055;KEGG: 00600+3.1.3.4;KEGG: 00564+3.1.3.4;Reactome: R-HSA-4419969;Reactome: R-HSA-1483213;MetaCyc: PWY-7782;Reactome: R-HSA-1483191;MetaCyc: PWY-6453	"2-arachidonoylglycerol biosynthesis";"Glycerolipid metabolism";"Anandamide biosynthesis II";"Ether lipid metabolism";"Anandamide biosynthesis I";"Triglyceride biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Sphingolipid metabolism";"Glycerophospholipid metabolism";"Depolymerisation of the Nuclear Lamina";"Synthesis of PE";"Plasmalogen biosynthesis";"Synthesis of PC";"Stigma estolide biosynthesis"
APLA007371-PA	8	Reactome: R-HSA-174430;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-69166;Reactome: R-HSA-68962;Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-113501	"Telomere C-strand synthesis initiation";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"Removal of the Flap Intermediate";"Activation of the pre-replicative complex";"Polymerase switching";"DNA replication initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1"
APLA006474-PA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
APLA002360-PA	4	Reactome: R-HSA-879415;Reactome: R-HSA-1799339;Reactome: R-HSA-6798695;Reactome: R-HSA-446203	"Advanced glycosylation endproduct receptor signaling";"SRP-dependent cotranslational protein targeting to membrane";"Neutrophil degranulation";"Asparagine N-linked glycosylation"
APLA009573-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA014398-PA	2	Reactome: R-HSA-8951671;Reactome: R-HSA-2032785	"RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression"
APLA005832-PA	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
APLA001987-PA	6	Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72702	"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition"
APLA003036-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA000509-PA	1	Reactome: R-HSA-400253	"Circadian Clock"
APLA012304-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA011986-PA	33	Reactome: R-HSA-9648025;Reactome: R-HSA-3301854;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-68877;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-170822;Reactome: R-HSA-2500257;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-141444;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-4551638;Reactome: R-HSA-159231;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-9610379;Reactome: R-HSA-6784531;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-5619107;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-159236	"EML4 and NUDC in mitotic spindle formation";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"Mitotic Prometaphase";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Resolution of Sister Chromatid Cohesion";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"HCMV Late Events";"tRNA processing in the nucleus";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA007022-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA011086-PA	9	Reactome: R-HSA-3656253;Reactome: R-HSA-2022928;Reactome: R-HSA-1971475;Reactome: R-HSA-3560801;Reactome: R-HSA-3560783;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096;Reactome: R-HSA-975634;Reactome: R-HSA-4420332	"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"HS-GAG biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GAT3 causes JDSSDHD";"Defective B4GALT7 causes EDS, progeroid type";"Defective EXT2 causes exostoses 2";"HS-GAG degradation";"Retinoid metabolism and transport";"Defective B3GALT6 causes EDSP2 and SEMDJL1"
APLA009995-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA004859-PA	1	Reactome: R-HSA-446199	"Synthesis of Dolichyl-phosphate"
APLA004044-PA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
APLA001921-PA	4	Reactome: R-HSA-9614399;Reactome: R-HSA-198693;Reactome: R-HSA-5674400;Reactome: R-HSA-9615017	"Regulation of localization of FOXO transcription factors";"AKT phosphorylates targets in the nucleus";"Constitutive Signaling by AKT1 E17K in Cancer";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
APLA003242-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA004652-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA012071-PA	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
APLA014869-PA	5	Reactome: R-HSA-975578;KEGG: 00533+2.4.1.68;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.68;KEGG: 00513+2.4.1.68	"Reactions specific to the complex N-glycan synthesis pathway";"Glycosaminoglycan biosynthesis - keratan sulfate";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis"
APLA008614-PA	13	Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72706	"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit"
APLA006128-PA	2	KEGG: 00052+3.2.1.26;KEGG: 00500+3.2.1.26	"Galactose metabolism";"Starch and sucrose metabolism"
APLA004544-PA	17	Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-6790901;Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"rRNA modification in the nucleus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA012660-PA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
APLA009415-PA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
APLA010995-PA	56	Reactome: R-HSA-5658442;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69017;Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-5610780;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174084;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-180585;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-8939236	"Regulation of RAS by GAPs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CDK-mediated phosphorylation and removal of Cdc6";"Defective CFTR causes cystic fibrosis";"Neddylation";"Separation of Sister Chromatids";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"Degradation of GLI1 by the proteasome";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of AXIN";"UCH proteinases";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Vif-mediated degradation of APOBEC3G";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
APLA013913-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA008521-PA	1	Reactome: R-HSA-8949613	"Cristae formation"
APLA007949-PA	6	Reactome: R-HSA-181430;Reactome: R-HSA-388844;Reactome: R-HSA-181429;Reactome: R-HSA-212676;Reactome: R-HSA-264642;Reactome: R-HSA-210500	"Norepinephrine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle"
APLA013701-PA	14	Reactome: R-HSA-8986944;Reactome: R-HSA-426486;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-426496;Reactome: R-HSA-9018519;Reactome: R-HSA-9022692;Reactome: R-HSA-4086398;Reactome: R-HSA-203927;Reactome: R-HSA-8943723;Reactome: R-HSA-8934593;Reactome: R-HSA-5628897;Reactome: R-HSA-9029569;Reactome: R-HSA-1912408	"Transcriptional Regulation by MECP2";"Small interfering RNA (siRNA) biogenesis";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Post-transcriptional silencing by small RNAs";"Estrogen-dependent gene expression";"Regulation of MECP2 expression and activity";"Ca2+ pathway";"MicroRNA (miRNA) biogenesis";"Regulation of PTEN mRNA translation";"Regulation of RUNX1 Expression and Activity";"TP53 Regulates Metabolic Genes";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Pre-NOTCH Transcription and Translation"
APLA009727-PA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
APLA009092-PA	3	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
APLA013231-PA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649	"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation"
APLA009098-PA	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
APLA012125-PA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-5205685	"Mitochondrial protein import";"Pink/Parkin Mediated Mitophagy"
APLA008801-PA	3	Reactome: R-HSA-400206;Reactome: R-HSA-427413;Reactome: R-HSA-8936459	"Regulation of lipid metabolism by PPARalpha";"NoRC negatively regulates rRNA expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
APLA007910-PA	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
APLA001015-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA000069-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA004082-PA	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
APLA009177-PA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
APLA001876-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA000414-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA003772-PA	2	Reactome: R-HSA-4549349;Reactome: R-HSA-446193	"Defective ALG2 causes ALG2-CDG (CDG-1i)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
APLA014725-PA	2	Reactome: R-HSA-9610379;Reactome: R-HSA-917729	"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)"
APLA008744-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA010570-PA	7	KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
APLA000252-PA	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
APLA014059-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA000773-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA009467-PA	3	MetaCyc: PWY-7546;Reactome: R-HSA-5358493;MetaCyc: PWY-6482	"Diphthamide biosynthesis II (eukaryotes)";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)"
APLA001456-PA	15	Reactome: R-HSA-75955;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167238;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-113418;Reactome: R-HSA-6807505;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-167290	"RNA Polymerase II Transcription Elongation";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of HIV elongation"
APLA002455-PA	2	Reactome: R-HSA-5663220;Reactome: R-HSA-376176	"RHO GTPases Activate Formins";"Signaling by ROBO receptors"
APLA010367-PA	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
APLA003682-PA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
APLA009005-PA	11	KEGG: 00740+3.6.1.9;MetaCyc: PWY-7187;KEGG: 00240+3.6.1.9;MetaCyc: PWY-6545;KEGG: 00500+3.6.1.9;KEGG: 00760+3.6.1.9;KEGG: 00230+3.6.1.9;MetaCyc: PWY-7184;MetaCyc: PWY-7821;KEGG: 00770+3.6.1.9;MetaCyc: PWY-7206	"Riboflavin metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Starch and sucrose metabolism";"Nicotinate and nicotinamide metabolism";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Tunicamycin biosynthesis";"Pantothenate and CoA biosynthesis";"Pyrimidine deoxyribonucleotides dephosphorylation"
APLA001837-PA	1	Reactome: R-HSA-2468052	"Establishment of Sister Chromatid Cohesion"
APLA002909-PA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-68877	"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Mitotic Prometaphase"
APLA014046-PA	13	Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-156902	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation"
APLA007118-PA	2	Reactome: R-HSA-114608;KEGG: 00970+6.1.1.3	"Platelet degranulation";"Aminoacyl-tRNA biosynthesis"
APLA004696-PA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
APLA007463-PA	56	Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-5678895;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-1236974	"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"Defective CFTR causes cystic fibrosis";"Separation of Sister Chromatids";"Neddylation";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway"
APLA011994-PA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
APLA010532-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA007375-PA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
APLA014874-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA003669-PA	1	Reactome: R-HSA-5666185	"RHO GTPases Activate Rhotekin and Rhophilins"
APLA007576-PA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
APLA013753-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA014334-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA001389-PA	3	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
APLA004803-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA007315-PA	3	KEGG: 00790+3.4.19.9;MetaCyc: PWY-2161B;Reactome: R-HSA-6798695	"Folate biosynthesis";"Glutamate removal from folates";"Neutrophil degranulation"
APLA009379-PA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
APLA002355-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
APLA008574-PA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
APLA011369-PA	1	Reactome: R-HSA-203754	"NOSIP mediated eNOS trafficking"
APLA008225-PA	13	Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72689	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits"
APLA003480-PA	22	Reactome: R-HSA-5339716;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-195253;Reactome: R-HSA-389513;Reactome: R-HSA-5358749;Reactome: R-HSA-68877;Reactome: R-HSA-5467348;Reactome: R-HSA-5673000;Reactome: R-HSA-5467340;Reactome: R-HSA-5358747;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-6811558;Reactome: R-HSA-2500257;Reactome: R-HSA-5358752;Reactome: R-HSA-432142;Reactome: R-HSA-5675221	"Misspliced GSK3beta mutants stabilize beta-catenin";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"Degradation of beta-catenin by the destruction complex";"CTLA4 inhibitory signaling";"S37 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Truncations of AMER1 destabilize the destruction complex";"RAF activation";"AXIN missense mutants destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Resolution of Sister Chromatid Cohesion";"T41 mutants of beta-catenin aren't phosphorylated";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway"
APLA002545-PA	31	MetaCyc: PWY-6519;Reactome: R-HSA-2426168;MetaCyc: PWY-4381;MetaCyc: PWY-7723;MetaCyc: PWY-8012;MetaCyc: PWY-8047;Reactome: R-HSA-163765;MetaCyc: PWY-5966-1;MetaCyc: PWY-7663;MetaCyc: PWY-8049;MetaCyc: PWY-6113;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7388;MetaCyc: PWY-5994;MetaCyc: PWY-5971;MetaCyc: PWY-5147;MetaCyc: PWY-5366;MetaCyc: PWYG-321;MetaCyc: PWY-5367;MetaCyc: PWY-6282;MetaCyc: PWY-7746;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;Reactome: R-HSA-75105;MetaCyc: PWY-5142;Reactome: R-HSA-9029558;MetaCyc: PWY-5973;MetaCyc: PWY-7858;Reactome: R-HSA-199220;MetaCyc: PWY-5989;MetaCyc: PWY-7664;MetaCyc: PWY-6799	"8-amino-7-oxononanoate biosynthesis I";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Bacterial bioluminescence";"Mupirocin biosynthesis";"Bryostatin biosynthesis";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Gondoate biosynthesis (anaerobic)";"Pederin biosynthesis";"Superpathway of mycolate biosynthesis";"Biotin metabolism";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis I (plants)";"Palmitoleate biosynthesis II (plants and bacteria)";"";"Petroselinate biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Mycobacterial sulfolipid biosynthesis";"Fatty acid biosynthesis";"Fatty acyl-CoA biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Cis-vaccenate biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Vitamin B5 (pantothenate) metabolism";"Stearate biosynthesis II (bacteria and plants)";"Oleate biosynthesis IV (anaerobic)";"Fatty acid biosynthesis initiation (plant mitochondria)"
APLA008862-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA015112-PA	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
APLA011060-PA	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
APLA005132-PA	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
APLA001426-PA	4	MetaCyc: PWY-7822;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902	"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)"
APLA001601-PA	56	Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-1236974;Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178	"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ER-Phagosome pathway";"Defective CFTR causes cystic fibrosis";"Neddylation";"Separation of Sister Chromatids";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
APLA012008-PA	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
APLA001397-PA	8	KEGG: 00052+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171	"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Fructose and mannose metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Glycolysis / Gluconeogenesis";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Glycolysis"
APLA002194-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA014024-PA	17	Reactome: R-HSA-6796648;KEGG: 04658+3.1.3.16;Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-75955;KEGG: 04660+3.1.3.16;Reactome: R-HSA-167246;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-113418;Reactome: R-HSA-167242;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-167200;KEGG: 05235+3.1.3.16	"TP53 Regulates Transcription of DNA Repair Genes";"Th1 and Th2 cell differentiation";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"T cell receptor signaling pathway";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"Formation of the Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA002074-PA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
APLA003482-PA	27	Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-3301854;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-4085377;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-170822;Reactome: R-HSA-5619107;Reactome: R-HSA-4615885;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-3232142;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-3371453	"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"ISG15 antiviral mechanism";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"SUMOylation of SUMOylation proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of DNA replication proteins";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of ubiquitinylation proteins";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response"
APLA002675-PA	12	Reactome: R-HSA-210744;Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-3214847;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-1912408;Reactome: R-HSA-9013508;Reactome: R-HSA-9013695;Reactome: R-HSA-350054	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"HATs acetylate histones";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"Pre-NOTCH Transcription and Translation";"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
APLA002639-PA	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
APLA010675-PA	6	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-975957;Reactome: R-HSA-9010553	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
APLA007946-PA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-5627123	"Clathrin-mediated endocytosis";"RHO GTPases activate PAKs"
APLA010596-PA	26	Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-5617833;Reactome: R-HSA-68877;Reactome: R-HSA-9619483;Reactome: R-HSA-380320;Reactome: R-HSA-2132295;Reactome: R-HSA-389960;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-983189;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-8955332;Reactome: R-HSA-6811434;Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-389977;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220	"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Cilium Assembly";"Mitotic Prometaphase";"Activation of AMPK downstream of NMDARs";"Recruitment of NuMA to mitotic centrosomes";"MHC class II antigen presentation";"Formation of tubulin folding intermediates by CCT/TriC";"Gap junction assembly";"HCMV Early Events";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Kinesins";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Carboxyterminal post-translational modifications of tubulin";"COPI-dependent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Post-chaperonin tubulin folding pathway";"Aggrephagy";"Separation of Sister Chromatids";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins"
APLA006746-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA008603-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA008095-PA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
APLA009856-PA	16	Reactome: R-HSA-8986944;Reactome: R-HSA-426496;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692;Reactome: R-HSA-4086398;Reactome: R-HSA-8943723;Reactome: R-HSA-8934593;Reactome: R-HSA-9029569;Reactome: R-HSA-5628897	"Transcriptional Regulation by MECP2";"Post-transcriptional silencing by small RNAs";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity";"Ca2+ pathway";"Regulation of PTEN mRNA translation";"Regulation of RUNX1 Expression and Activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"TP53 Regulates Metabolic Genes"
APLA000547-PA	18	Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167238;Reactome: R-HSA-167160;Reactome: R-HSA-6807505;Reactome: R-HSA-112382;Reactome: R-HSA-6796648;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-167246	"mRNA Capping";"Formation of the Early Elongation Complex";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA polymerase II transcribes snRNA genes";"Formation of RNA Pol II elongation complex";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Tat-mediated elongation of the HIV-1 transcript"
APLA001846-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA013024-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA007820-PA	1	Reactome: R-HSA-1483191	"Synthesis of PC"
APLA006974-PA	5	Reactome: R-HSA-72163;Reactome: R-HSA-159231;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"mRNA Splicing - Major Pathway";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
APLA010654-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA004816-PA	2	KEGG: 00240+4.2.1.70;MetaCyc: PWY-6019	"Pyrimidine metabolism";"Pseudouridine degradation"
APLA010839-PA	13	Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA002087-PA	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
APLA013392-PA	13	Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
APLA010143-PA	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
APLA001387-PA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
APLA012544-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA008839-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA000271-PA	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
APLA012657-PA	3	Reactome: R-HSA-1362409;Reactome: R-HSA-1268020;KEGG: 00860+1.16.3.1	"Mitochondrial iron-sulfur cluster biogenesis";"Mitochondrial protein import";"Porphyrin and chlorophyll metabolism"
APLA004465-PA	4	Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664	"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"Neddylation"
APLA010448-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA009210-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA004617-PA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
APLA006252-PA	4	MetaCyc: PWY-5737;Reactome: R-HSA-70688;KEGG: 00330+1.5.5.2;MetaCyc: PWY-6922	"(5R)-carbapenem carboxylate biosynthesis";"Proline catabolism";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis"
APLA005785-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA003843-PA	4	Reactome: R-HSA-2586552;Reactome: R-HSA-983231;Reactome: R-HSA-1170546;Reactome: R-HSA-982772	"Signaling by Leptin";"Factors involved in megakaryocyte development and platelet production";"Prolactin receptor signaling";"Growth hormone receptor signaling"
APLA014683-PA	10	KEGG: 00562+2.7.1.158;Reactome: R-HSA-1855191;KEGG: 04070+2.7.1.158;MetaCyc: PWY-6362;MetaCyc: PWY-4661;MetaCyc: PWY-6554;MetaCyc: PWY-6372;MetaCyc: PWY-6369;MetaCyc: PWY-6361;Reactome: R-HSA-1855167	"Inositol phosphate metabolism";"Synthesis of IPs in the nucleus";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Synthesis of pyrophosphates in the cytosol"
APLA000332-PA	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
APLA006438-PA	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
APLA012266-PA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
APLA005063-PA	3	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
APLA005950-PA	4	Reactome: R-HSA-196757;KEGG: 00670+1.5.1.6;KEGG: 00670+2.1.2.9;KEGG: 00970+2.1.2.9	"Metabolism of folate and pterines";"One carbon pool by folate";"One carbon pool by folate";"Aminoacyl-tRNA biosynthesis"
APLA008846-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA000239-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA011863-PA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
APLA003507-PA	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
APLA001819-PA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
APLA008995-PA	7	Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-2565942	"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition"
APLA000757-PA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
APLA013911-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA002373-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA011364-PA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
APLA010842-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA006575-PA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
APLA009927-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA006927-PA	1	Reactome: R-HSA-5617833	"Cilium Assembly"
APLA005870-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA009658-PA	7	Reactome: R-HSA-166208;Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852	"mTORC1-mediated signalling";"Regulation of PTEN gene transcription";"mTOR signalling";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy"
APLA008229-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA009586-PA	3	KEGG: 00970+6.1.1.4;Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
APLA009226-PA	4	Reactome: R-HSA-422085;Reactome: R-HSA-381771;Reactome: R-HSA-1799339;Reactome: R-HSA-400511	"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"
APLA003237-PA	5	Reactome: R-HSA-1660662;Reactome: R-HSA-2132295;Reactome: R-HSA-6798695;Reactome: R-HSA-4085001;Reactome: R-HSA-4341670	"Glycosphingolipid metabolism";"MHC class II antigen presentation";"Neutrophil degranulation";"Sialic acid metabolism";"Defective NEU1 causes sialidosis"
APLA003813-PA	5	MetaCyc: PWY-6855;Reactome: R-HSA-189085;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902	"Chitin degradation I (archaea)";"Digestion of dietary carbohydrate";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)"
APLA004632-PA	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
APLA001936-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA008691-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA006697-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA000303-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA005967-PA	3	Reactome: R-HSA-6783984;KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"Glycine degradation";"One carbon pool by folate";"Glycine, serine and threonine metabolism"
APLA005612-PA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
APLA007870-PA	4	Reactome: R-HSA-1483191;KEGG: 00564+3.1.1.7;Reactome: R-HSA-112311;Reactome: R-HSA-422085	"Synthesis of PC";"Glycerophospholipid metabolism";"Neurotransmitter clearance";"Synthesis, secretion, and deacylation of Ghrelin"
APLA012561-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA015383-PA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
APLA002494-PA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
APLA011655-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA012593-PA	56	Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-1236978;Reactome: R-HSA-1236974;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-180585	"Defective CFTR causes cystic fibrosis";"Neddylation";"Separation of Sister Chromatids";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Cross-presentation of soluble exogenous antigens (endosomes)";"ER-Phagosome pathway";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G"
APLA002114-PA	16	Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-156827	"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression"
APLA001003-PA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
APLA014154-PA	2	Reactome: R-HSA-71384;KEGG: 00030+1.1.1.47	"Ethanol oxidation";"Pentose phosphate pathway"
APLA008708-PA	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
APLA002651-PA	2	Reactome: R-HSA-181429;Reactome: R-HSA-212676	"Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle"
APLA006050-PA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
APLA007498-PA	7	Reactome: R-HSA-1632852;Reactome: R-HSA-198323;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-8854214;Reactome: R-HSA-5674400;Reactome: R-HSA-165181	"Macroautophagy";"AKT phosphorylates targets in the cytosol";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"TBC/RABGAPs";"Constitutive Signaling by AKT1 E17K in Cancer";"Inhibition of TSC complex formation by PKB"
APLA006918-PA	9	MetaCyc: PWY-7852;MetaCyc: PWY-5663;MetaCyc: PWY-6147;Reactome: R-HSA-1474151;MetaCyc: PWY-7442;KEGG: 00790+3.5.4.16;MetaCyc: PWY-5664;MetaCyc: PWY-6703;MetaCyc: PWY-6983	"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Erythro-tetrahydrobiopterin biosynthesis I";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Drosopterin and aurodrosopterin biosynthesis";"Folate biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis II";"Preq0 biosynthesis";"Threo-tetrahydrobiopterin biosynthesis"
APLA002270-PA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
APLA005748-PA	18	KEGG: 00565+3.1.1.4;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-8051;Reactome: R-HSA-1482839;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7417;MetaCyc: PWY-6803;Reactome: R-HSA-1482788;MetaCyc: PWY-7783;Reactome: R-HSA-1482922;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482925;Reactome: R-HSA-1482801	"Ether lipid metabolism";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Acyl chain remodelling of PE";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PC";"Plasmalogen degradation";"Acyl chain remodelling of PI";"Synthesis of PA";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Acyl chain remodelling of PG";"Acyl chain remodelling of PS"
APLA002731-PA	5	MetaCyc: PWY-7817;MetaCyc: PWY-5981;KEGG: 00564+2.7.7.41;KEGG: 04070+2.7.7.41;MetaCyc: PWY-5667	"Type I lipoteichoic acid biosynthesis (S. aureus)";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"CDP-diacylglycerol biosynthesis I"
APLA014196-PA	7	MetaCyc: PWY-7445;MetaCyc: PWY-5469;MetaCyc: PWY-5466;MetaCyc: PWY-5461;MetaCyc: PWY-7214;MetaCyc: PWY-6824;KEGG: 00940+1.11.1.7	"Luteolin triglucuronide degradation";"Sesamin biosynthesis";"Matairesinol biosynthesis";"Betanidin degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Justicidin B biosynthesis";"Phenylpropanoid biosynthesis"
APLA011250-PA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
APLA015481-PA	3	Reactome: R-HSA-375276;Reactome: R-HSA-418594;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (i) signalling events";"G alpha (q) signalling events"
APLA012302-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA003429-PA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
APLA011318-PA	3	Reactome: R-HSA-1614603;Reactome: R-HSA-2408508;Reactome: R-HSA-1614558	"Cysteine formation from homocysteine";"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Degradation of cysteine and homocysteine"
APLA013703-PA	52	Reactome: R-HSA-72165;Reactome: R-HSA-6782210;Reactome: R-HSA-73780;Reactome: R-HSA-6781827;Reactome: R-HSA-749476;Reactome: R-HSA-5617472;Reactome: R-HSA-73772;Reactome: R-HSA-6796648;Reactome: R-HSA-6807505;Reactome: R-HSA-167238;Reactome: R-HSA-9018519;Reactome: R-HSA-76066;Reactome: R-HSA-73762;Reactome: R-HSA-1834949;Reactome: R-HSA-167242;Reactome: R-HSA-76071;Reactome: R-HSA-167246;Reactome: R-HSA-6782135;Reactome: R-HSA-73980;Reactome: R-HSA-77075;Reactome: R-HSA-5601884;Reactome: R-HSA-75955;Reactome: R-HSA-76061;Reactome: R-HSA-167290;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-72163;Reactome: R-HSA-73779;Reactome: R-HSA-8851708;Reactome: R-HSA-167160;Reactome: R-HSA-203927;Reactome: R-HSA-112382;Reactome: R-HSA-75953;Reactome: R-HSA-5578749;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-6803529;Reactome: R-HSA-76042;Reactome: R-HSA-5250924;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-427413;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-72203;Reactome: R-HSA-167287;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-113418;Reactome: R-HSA-72086	"mRNA Splicing - Minor Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase III Chain Elongation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase III Abortive And Retractive Initiation";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase I Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA polymerase II transcribes snRNA genes";"Pausing and recovery of Tat-mediated HIV elongation";"Estrogen-dependent gene expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase I Transcription Initiation";"Cytosolic sensors of pathogen-associated DNA";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Tat-mediated elongation of the HIV-1 transcript";"Dual incision in TC-NER";"RNA Polymerase III Transcription Termination";"RNA Pol II CTD phosphorylation and interaction with CE";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase II Transcription Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Pausing and recovery of HIV elongation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Signaling by FGFR2 IIIa TM";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"MicroRNA (miRNA) biogenesis";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Initiation";"Transcriptional regulation by small RNAs";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"FGFR2 alternative splicing";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"B-WICH complex positively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"NoRC negatively regulates rRNA expression";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"Processing of Capped Intron-Containing Pre-mRNA";"HIV elongation arrest and recovery";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the Early Elongation Complex";"mRNA Capping"
APLA007662-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA008220-PA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
APLA004796-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA001443-PA	5	KEGG: 00520+2.7.1.6;MetaCyc: PWY-6317;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6527	"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"D-galactose detoxification";"Stachyose degradation"
APLA012083-PA	8	KEGG: 00562+5.5.1.4;Reactome: R-HSA-1855183;MetaCyc: PWY-2301;MetaCyc: PWY-4661;MetaCyc: PWY-6664;MetaCyc: PWY-6580;KEGG: 00521+5.5.1.4;MetaCyc: PWY-6372	"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Di-myo-inositol phosphate biosynthesis";"Phosphatidylinositol biosynthesis I (bacteria)";"Streptomycin biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)"
APLA003769-PA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
APLA008745-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA002303-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA009966-PA	7	Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2660826;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-2691232	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
APLA013928-PA	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
APLA010096-PA	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
APLA011532-PA	6	Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-69052	"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state"
APLA008766-PA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA000667-PA	3	Reactome: R-HSA-9603798;Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Class I peroxisomal membrane protein import";"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
APLA008185-PA	1	Reactome: R-HSA-5649702	"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"
APLA015314-PA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
APLA004738-PA	3	Reactome: R-HSA-5693571;Reactome: R-HSA-3108214;Reactome: R-HSA-164843	"Nonhomologous End-Joining (NHEJ)";"SUMOylation of DNA damage response and repair proteins";"2-LTR circle formation"
APLA012969-PA	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
APLA011825-PA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
APLA011927-PA	5	Reactome: R-HSA-1912408;Reactome: R-HSA-1912420;Reactome: R-HSA-350054;Reactome: R-HSA-5083630;Reactome: R-HSA-1912399	"Pre-NOTCH Transcription and Translation";"Pre-NOTCH Processing in Golgi";"Notch-HLH transcription pathway";"Defective LFNG causes SCDO3";"Pre-NOTCH Processing in the Endoplasmic Reticulum"
APLA001018-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA003127-PA	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
APLA003222-PA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
APLA006650-PA	1	Reactome: R-HSA-5676934	"Protein repair"
APLA014513-PA	9	Reactome: R-HSA-174411;Reactome: R-HSA-69183;Reactome: R-HSA-174430;Reactome: R-HSA-68952;Reactome: R-HSA-69091;Reactome: R-HSA-68962;Reactome: R-HSA-113501;Reactome: R-HSA-69205;Reactome: R-HSA-69166	"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Telomere C-strand synthesis initiation";"DNA replication initiation";"Polymerase switching";"Activation of the pre-replicative complex";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"G1/S-Specific Transcription";"Removal of the Flap Intermediate"
APLA001009-PA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
APLA004099-PA	4	MetaCyc: PWY-6483;Reactome: R-HSA-1660662;MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23	"Ceramide degradation (generic)";"Glycosphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism"
APLA005702-PA	5	Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-427389;Reactome: R-HSA-6804758	"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation"
APLA001572-PA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
APLA000079-PA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
APLA005525-PA	4	MetaCyc: PWY-6855;MetaCyc: PWY-7822;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14	"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism"
APLA009483-PA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
APLA008788-PA	5	Reactome: R-HSA-6782135;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER"
APLA003586-PA	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
APLA005912-PA	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
APLA000050-PA	6	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex"
APLA004877-PA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-264876;Reactome: R-HSA-5620916	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing";"VxPx cargo-targeting to cilium"
APLA008941-PA	5	MetaCyc: PWY-6344;MetaCyc: PWY-4981;Reactome: R-HSA-8964539;MetaCyc: PWY-3341;KEGG: 00330+1.5.1.2	"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)";"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism"
APLA004572-PA	4	Reactome: R-HSA-3108214;Reactome: R-HSA-532668;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394	"SUMOylation of DNA damage response and repair proteins";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER"
APLA011772-PA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
APLA000040-PA	4	Reactome: R-HSA-70895;KEGG: 00640+1.2.1.27;KEGG: 00280+1.2.1.27;MetaCyc: PWY-5642	"Branched-chain amino acid catabolism";"Propanoate metabolism";"Valine, leucine and isoleucine degradation";"2,4-dinitrotoluene degradation"
APLA009882-PA	8	Reactome: R-HSA-111458;Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-6803207;Reactome: R-HSA-8953750;Reactome: R-HSA-6798695;Reactome: R-HSA-9627069;Reactome: R-HSA-111459	"Formation of apoptosome";"SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Transcriptional Regulation by E2F6";"Neutrophil degranulation";"Regulation of the apoptosome activity";"Activation of caspases through apoptosome-mediated cleavage"
APLA003470-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA009436-PA	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
APLA014017-PA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
APLA007097-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA004372-PA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
APLA014713-PA	12	Reactome: R-HSA-2979096;Reactome: R-HSA-193692;Reactome: R-HSA-3928665;Reactome: R-HSA-205043;Reactome: R-HSA-977225;Reactome: R-HSA-1251985;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-9013700;Reactome: R-HSA-9017802;Reactome: R-HSA-2644606	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Regulated proteolysis of p75NTR";"EPH-ephrin mediated repulsion of cells";"NRIF signals cell death from the nucleus";"Amyloid fiber formation";"Nuclear signaling by ERBB4";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
APLA012570-PA	7	KEGG: 00670+1.5.1.3;Reactome: R-HSA-69205;MetaCyc: PWY-6614;Reactome: R-HSA-196757;Reactome: R-HSA-1474151;KEGG: 00790+1.5.1.3;MetaCyc: PWY-3841	"One carbon pool by folate";"G1/S-Specific Transcription";"Tetrahydrofolate biosynthesis";"Metabolism of folate and pterines";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis";"Folate transformations II (plants)"
APLA015217-PA	5	Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556	"Insulin receptor recycling";"Ion channel transport";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes"
APLA005493-PA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
APLA000110-PA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
APLA002938-PA	27	Reactome: R-HSA-167200;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-6803529;Reactome: R-HSA-77595;Reactome: R-HSA-975957;Reactome: R-HSA-111367;Reactome: R-HSA-159236;Reactome: R-HSA-674695;Reactome: R-HSA-191859;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-167152;Reactome: R-HSA-9010553;Reactome: R-HSA-77588;Reactome: R-HSA-72203;Reactome: R-HSA-159227;Reactome: R-HSA-72165;Reactome: R-HSA-8851708;Reactome: R-HSA-72163;Reactome: R-HSA-159231;Reactome: R-HSA-975956;Reactome: R-HSA-112382;Reactome: R-HSA-6807505;Reactome: R-HSA-159230	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"FGFR2 alternative splicing";"Processing of Intronless Pre-mRNAs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SLBP independent Processing of Histone Pre-mRNAs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Pre-transcription Events";"snRNP Assembly";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Capping";"Formation of the Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"Regulation of expression of SLITs and ROBOs";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"Processing of Capped Intron-Containing Pre-mRNA";"Transport of the SLBP independent Mature mRNA";"mRNA Splicing - Minor Pathway";"Signaling by FGFR2 IIIa TM";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of RNA Pol II elongation complex";"RNA polymerase II transcribes snRNA genes";"Transport of the SLBP Dependant Mature mRNA"
APLA011553-PA	2	Reactome: R-HSA-1222556;Reactome: R-HSA-392154	"ROS and RNS production in phagocytes";"Nitric oxide stimulates guanylate cyclase"
APLA005242-PA	6	Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
APLA009304-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
APLA004319-PA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
APLA001307-PA	6	Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-69052	"Assembly of the pre-replicative complex";"Unwinding of DNA";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state"
APLA000490-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA015192-PA	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
APLA007920-PA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
APLA014581-PA	1	Reactome: R-HSA-419771	"Opsins"
APLA014344-PA	1	Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Holliday Junction Intermediates"
APLA012829-PA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
APLA001395-PA	6	Reactome: R-HSA-8964539;MetaCyc: PWY-4981;MetaCyc: PWY-3341;KEGG: 00330+2.6.1.13;MetaCyc: PWY-6922;MetaCyc: PWY-6344	"Glutamate and glutamine metabolism";"L-proline biosynthesis II (from arginine)";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis";"L-ornithine degradation II (Stickland reaction)"
APLA005719-PA	56	Reactome: R-HSA-8939236;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-180585;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-174084;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603;Reactome: R-HSA-382556;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-75815;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5678895;Reactome: R-HSA-69017;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-5658442	"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of AXIN";"UCH proteinases";"ABC-family proteins mediated transport";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Ubiquitin-dependent degradation of Cyclin D";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Neddylation";"Defective CFTR causes cystic fibrosis";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RAS by GAPs"
APLA009232-PA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
APLA011587-PA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
APLA010672-PA	3	MetaCyc: PWY-7942;Reactome: R-HSA-174403;KEGG: 00480+4.3.2.7	"5-oxo-L-proline metabolism";"Glutathione synthesis and recycling";"Glutathione metabolism"
APLA011062-PA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
APLA012698-PA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
APLA005954-PA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
APLA007067-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA005600-PA	1	Reactome: R-HSA-71288	"Creatine metabolism"
APLA012988-PA	3	Reactome: R-HSA-196741;Reactome: R-HSA-3359471;KEGG: 00860+2.5.1.17	"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective MMAB causes methylmalonic aciduria type cblB";"Porphyrin and chlorophyll metabolism"
APLA003061-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA002428-PA	57	Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-6798695;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-382556;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-5678895;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-1236974	"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Neutrophil degranulation";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"ABC-family proteins mediated transport";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"Defective CFTR causes cystic fibrosis";"Separation of Sister Chromatids";"Neddylation";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway"
APLA001414-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA000601-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
APLA006509-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA009419-PA	5	Reactome: R-HSA-8856825;Reactome: R-HSA-432722;Reactome: R-HSA-6811440;Reactome: R-HSA-6798695;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Golgi Associated Vesicle Biogenesis";"Retrograde transport at the Trans-Golgi-Network";"Neutrophil degranulation";"Clathrin-mediated endocytosis"
APLA003042-PA	3	KEGG: 00130+4.1.1.90;MetaCyc: PWY-7999;Reactome: R-HSA-159740	"Ubiquinone and other terpenoid-quinone biosynthesis";"Vitamin K-epoxide cycle";"Gamma-carboxylation of protein precursors"
APLA007750-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA007954-PA	4	MetaCyc: PWY-7286;MetaCyc: PWY-7285;MetaCyc: PWY-6829;Reactome: R-HSA-6782861	"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Methylwyosine biosynthesis";"Trna methylation (yeast)";"Synthesis of wybutosine at G37 of tRNA(Phe)"
APLA006547-PA	10	MetaCyc: PWY-7003;Reactome: R-HSA-70171;KEGG: 00010+5.3.1.1;MetaCyc: PWY-5484;KEGG: 00051+5.3.1.1;Reactome: R-HSA-70263;MetaCyc: PWY-6142;MetaCyc: PWY-1042;KEGG: 00562+5.3.1.1;KEGG: 00710+5.3.1.1	"Glycerol degradation to butanol";"Glycolysis";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Fructose and mannose metabolism";"Gluconeogenesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)";"Inositol phosphate metabolism";"Carbon fixation in photosynthetic organisms"
APLA006597-PA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
APLA008463-PA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
APLA014868-PA	5	KEGG: 00513+2.4.1.68;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.68;Reactome: R-HSA-975578;KEGG: 00533+2.4.1.68	"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway";"Glycosaminoglycan biosynthesis - keratan sulfate"
APLA000537-PA	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
APLA008154-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA001685-PA	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
APLA000953-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA005398-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA002022-PA	3	Reactome: R-HSA-5656169;Reactome: R-HSA-110320;Reactome: R-HSA-5685942	"Termination of translesion DNA synthesis";"Translesion Synthesis by POLH";"HDR through Homologous Recombination (HRR)"
APLA000499-PA	14	MetaCyc: PWY-3661-1;KEGG: 00670+2.1.2.1;KEGG: 00260+2.1.2.1;MetaCyc: PWY-3661;MetaCyc: PWY-3841;KEGG: 00460+2.1.2.1;MetaCyc: PWY-1622;MetaCyc: PWY-181;MetaCyc: PWY-5497;MetaCyc: PWY-2161;Reactome: R-HSA-196757;KEGG: 00680+2.1.2.1;KEGG: 00630+2.1.2.1;MetaCyc: PWY-2201	"Glycine betaine degradation II (mammalian)";"One carbon pool by folate";"Glycine, serine and threonine metabolism";"Glycine betaine degradation I";"Folate transformations II (plants)";"Cyanoamino acid metabolism";"Formaldehyde assimilation I (serine pathway)";"Photorespiration ";"Purine nucleobases degradation II (anaerobic)";"Folate polyglutamylation";"Metabolism of folate and pterines";"Methane metabolism";"Glyoxylate and dicarboxylate metabolism";"Folate transformations I"
APLA004415-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA011432-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA005606-PA	5	KEGG: 04150+2.7.11.24;Reactome: R-HSA-168638;Reactome: R-HSA-376172;Reactome: R-HSA-4420097;Reactome: R-HSA-171007	"mTOR signaling pathway";"NOD1/2 Signaling Pathway";"DSCAM interactions";"VEGFA-VEGFR2 Pathway";"p38MAPK events"
APLA002838-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA001945-PA	2	Reactome: R-HSA-8964539;Reactome: R-HSA-2151201	"Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis"
APLA013662-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA005949-PA	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-2894862	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
APLA001416-PA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
APLA005327-PA	5	Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387	"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling"
APLA006663-PA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA000328-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA006387-PA	12	MetaCyc: PWY-7118;KEGG: 00010+6.2.1.1;MetaCyc: PWY-5108;MetaCyc: PWY-5132;KEGG: 00680+6.2.1.1;KEGG: 00640+6.2.1.1;KEGG: 00630+6.2.1.1;MetaCyc: PWY-6672;KEGG: 00620+6.2.1.1;KEGG: 00720+6.2.1.1;MetaCyc: PWY-7857;MetaCyc: PWY-5133	"Chitin degradation to ethanol";"Glycolysis / Gluconeogenesis";"L-isoleucine biosynthesis V";"Lupulone and humulone biosynthesis";"Methane metabolism";"Propanoate metabolism";"Glyoxylate and dicarboxylate metabolism";"Cis-genanyl-coa degradation";"Pyruvate metabolism";"Carbon fixation pathways in prokaryotes";"Adlupulone and adhumulone biosynthesis";"Colupulone and cohumulone biosynthesis"
APLA001520-PA	2	Reactome: R-HSA-6804756;Reactome: R-HSA-8854518	"Regulation of TP53 Activity through Phosphorylation";"AURKA Activation by TPX2"
APLA013280-PA	4	Reactome: R-HSA-964975;MetaCyc: PWY-7204;MetaCyc: PWY-7282;KEGG: 00750+1.4.3.5	"Vitamins B6 activation to pyridoxal phosphate";"Pyridoxal 5'-phosphate salvage II (plants)";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Vitamin B6 metabolism"
APLA014873-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA009260-PA	3	Reactome: R-HSA-947581;KEGG: 00790+2.10.1.1;MetaCyc: PWY-6823	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
APLA010787-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA005458-PA	6	MetaCyc: PWY-7346;MetaCyc: PWY-7820;KEGG: 00053+1.1.1.22;KEGG: 00040+1.1.1.22;Reactome: R-HSA-173599;KEGG: 00520+1.1.1.22	"UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)";"Teichuronic acid biosynthesis (B. subtilis 168)";"Ascorbate and aldarate metabolism";"Pentose and glucuronate interconversions";"Formation of the active cofactor, UDP-glucuronate";"Amino sugar and nucleotide sugar metabolism"
APLA001319-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA003467-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA013393-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA003172-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA006203-PA	2	Reactome: R-HSA-3371599;Reactome: R-HSA-196780	"Defective HLCS causes multiple carboxylase deficiency";"Biotin transport and metabolism"
APLA002840-PA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
APLA000690-PA	2	Reactome: R-HSA-5683371;Reactome: R-HSA-1369007	"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)";"Mitochondrial ABC transporters"
APLA004837-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA003677-PA	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
APLA006557-PA	9	Reactome: R-HSA-416476;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351;Reactome: R-HSA-112043;MetaCyc: PWY-8052	"G alpha (q) signalling events";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"PLC beta mediated events";"2-arachidonoylglycerol biosynthesis"
APLA005482-PA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
APLA001626-PA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
APLA010464-PA	3	Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
APLA009744-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA013156-PA	1	Reactome: R-HSA-499943	"Interconversion of nucleotide di- and triphosphates"
APLA011848-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA001011-PA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
APLA005550-PA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
APLA002236-PA	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
APLA004923-PA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
APLA014432-PA	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
APLA008436-PA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
APLA000125-PA	1	Reactome: R-HSA-1234174	"Cellular response to hypoxia"
APLA002024-PA	7	KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection"
APLA007715-PA	8	Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-176187;Reactome: R-HSA-68616;Reactome: R-HSA-68867;Reactome: R-HSA-68689	"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex";"CDC6 association with the ORC:origin complex"
APLA002737-PA	1	Reactome: R-HSA-1614635	"Sulfur amino acid metabolism"
APLA009959-PA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
APLA008830-PA	8	Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7922;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5083633;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921	"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)"
APLA008596-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA008242-PA	7	KEGG: 00562+3.1.3.25;MetaCyc: PWY-4702;MetaCyc: PWY-6363;KEGG: 00521+3.1.3.25;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25;MetaCyc: PWY-2301	"Inositol phosphate metabolism";"Phytate degradation I";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Streptomycin biosynthesis";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Myo-inositol biosynthesis"
APLA006330-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA012981-PA	4	MetaCyc: PWY-7375;Reactome: R-HSA-77075;Reactome: R-HSA-167160;Reactome: R-HSA-72086	"Mrna capping I";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"mRNA Capping"
APLA008799-PA	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
APLA001093-PA	6	Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex"
APLA004095-PA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
APLA005624-PA	1	Reactome: R-HSA-200425	"Carnitine metabolism"
APLA012596-PA	6	Reactome: R-HSA-3214815;Reactome: R-HSA-9022692;Reactome: R-HSA-1989781;Reactome: R-HSA-9022537;Reactome: R-HSA-9609690;Reactome: R-HSA-9029569	"HDACs deacetylate histones";"Regulation of MECP2 expression and activity";"PPARA activates gene expression";"Loss of MECP2 binding ability to the NCoR/SMRT complex";"HCMV Early Events";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
APLA011248-PA	5	Reactome: R-HSA-174403;KEGG: 00480+6.3.2.3;KEGG: 00270+6.3.2.3;MetaCyc: PWY-8043;Reactome: R-HSA-5579006	"Glutathione synthesis and recycling";"Glutathione metabolism";"Cysteine and methionine metabolism";"Ophthalmate biosynthesis";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)"
APLA012910-PA	16	Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695	"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex"
APLA011947-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA014787-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA006947-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA003598-PA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
APLA012813-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
APLA005501-PA	3	Reactome: R-HSA-6811434;Reactome: R-HSA-6798695;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation";"COPI-mediated anterograde transport"
APLA004501-PA	7	MetaCyc: PWY-5686;KEGG: 00240+2.4.2.10;Reactome: R-HSA-500753;KEGG: 00240+4.1.1.23;MetaCyc: PWY-7790;MetaCyc: PWY-7791;KEGG: 00983+2.4.2.10	"UMP biosynthesis I";"Pyrimidine metabolism";"Pyrimidine biosynthesis";"Pyrimidine metabolism";"UMP biosynthesis II";"UMP biosynthesis III";"Drug metabolism - other enzymes"
APLA007805-PA	6	Reactome: R-HSA-163560;KEGG: 05235+3.1.3.16;Reactome: R-HSA-2173788;Reactome: R-HSA-400253;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"Triglyceride catabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Downregulation of TGF-beta receptor signaling";"Circadian Clock";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
APLA007426-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA008466-PA	1	Reactome: R-HSA-6785631	"ERBB2 Regulates Cell Motility"
APLA002345-PA	11	Reactome: R-HSA-500753;KEGG: 00240+3.5.2.3;KEGG: 00250+2.1.3.2;MetaCyc: PWY-7400;MetaCyc: PWY-5154;KEGG: 00240+2.1.3.2;MetaCyc: PWY-7790;KEGG: 00240+6.3.5.5;KEGG: 00250+6.3.5.5;MetaCyc: PWY-5686;MetaCyc: PWY-7791	"Pyrimidine biosynthesis";"Pyrimidine metabolism";"Alanine, aspartate and glutamate metabolism";"L-arginine biosynthesis IV (archaebacteria)";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Pyrimidine metabolism";"UMP biosynthesis II";"Pyrimidine metabolism";"Alanine, aspartate and glutamate metabolism";"UMP biosynthesis I";"UMP biosynthesis III"
APLA011309-PA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
APLA014097-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA014646-PA	10	Reactome: R-HSA-167172;Reactome: R-HSA-6804756;Reactome: R-HSA-3214847;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-674695	"Transcription of the HIV genome";"Regulation of TP53 Activity through Phosphorylation";"HATs acetylate histones";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events"
APLA011270-PA	4	Reactome: R-HSA-427389;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815;Reactome: R-HSA-73762	"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of PTEN gene transcription";"HDACs deacetylate histones";"RNA Polymerase I Transcription Initiation"
APLA015453-PA	6	KEGG: 00030+5.1.3.1;MetaCyc: PWY-1861;KEGG: 00710+5.1.3.1;Reactome: R-HSA-71336;KEGG: 00040+5.1.3.1;MetaCyc: PWY-5723	"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway";"Pentose and glucuronate interconversions";"Rubisco shunt"
APLA012875-PA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA001638-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA000781-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA010752-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA014966-PA	9	MetaCyc: PWY-7117;KEGG: 00910+4.2.1.1;Reactome: R-HSA-1475029;MetaCyc: PWY-5744;MetaCyc: PWY-241;MetaCyc: PWY-5743;MetaCyc: PWY-6142;MetaCyc: PWY-5789;MetaCyc: PWY-7115	"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Nitrogen metabolism";"Reversible hydration of carbon dioxide";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"3-hydroxypropanoate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type"
APLA008442-PA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
APLA014831-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
APLA001878-PA	19	Reactome: R-HSA-6798695;KEGG: 00020+6.2.1.5;MetaCyc: PWY-7384;MetaCyc: PWY-5690;KEGG: 00020+2.3.3.8;KEGG: 00640+6.2.1.5;Reactome: R-HSA-75105;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5537;Reactome: R-HSA-71403;MetaCyc: PWY-6728;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5172;Reactome: R-HSA-163765;MetaCyc: PWY-5538;MetaCyc: PWY-6969;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-5913	"Neutrophil degranulation";"Citrate cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle II (plants and fungi)";"Citrate cycle (TCA cycle)";"Propanoate metabolism";"Fatty acyl-CoA biosynthesis";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"C5-Branched dibasic acid metabolism";"Acetyl-coa biosynthesis III (from citrate)";"ChREBP activates metabolic gene expression";"Pyruvate fermentation to acetate VI";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Partial TCA cycle (obligate autotrophs)"
APLA011443-PA	1	Reactome: R-HSA-400253	"Circadian Clock"
APLA015208-PA	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
APLA005412-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA014197-PA	4	Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-5696400;Reactome: R-HSA-5696395	"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER"
APLA014250-PA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
APLA005998-PA	7	Reactome: R-HSA-204174;KEGG: 00020+1.2.4.1;KEGG: 00620+1.2.4.1;Reactome: R-HSA-5362517;Reactome: R-HSA-70268;Reactome: R-HSA-389661;KEGG: 00010+1.2.4.1	"Regulation of pyruvate dehydrogenase (PDH) complex";"Citrate cycle (TCA cycle)";"Pyruvate metabolism";"Signaling by Retinoic Acid";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Glycolysis / Gluconeogenesis"
APLA014804-PA	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
APLA012568-PA	2	Reactome: R-HSA-70921;KEGG: 00340+2.1.1.22	"Histidine catabolism";"Histidine metabolism"
APLA008024-PA	5	KEGG: 00564+1.1.1.94;MetaCyc: PWY-5667;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;MetaCyc: PWY-7902	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"Glucosylglycerol biosynthesis"
APLA000730-PA	10	Reactome: R-HSA-6798695;Reactome: R-HSA-975634;KEGG: 00230+3.5.2.17;MetaCyc: PWY-7394;Reactome: R-HSA-2453864;MetaCyc: PWY-7849;Reactome: R-HSA-3000171;MetaCyc: PWY-5691;Reactome: R-HSA-977225;Reactome: R-HSA-2453902	"Neutrophil degranulation";"Retinoid metabolism and transport";"Purine metabolism";"Urate conversion to allantoin II";"Retinoid cycle disease events";"Urate conversion to allantoin III";"Non-integrin membrane-ECM interactions";"Urate conversion to allantoin I";"Amyloid fiber formation";"The canonical retinoid cycle in rods (twilight vision)"
APLA003093-PA	6	Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72695	"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex"
APLA004865-PA	7	KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
APLA000828-PA	6	MetaCyc: PWY-7391;KEGG: 00900+4.1.1.33;Reactome: R-HSA-191273;Reactome: R-HSA-446199;MetaCyc: PWY-922;Reactome: R-HSA-2426168	"Isoprene biosynthesis II (engineered)";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"Synthesis of Dolichyl-phosphate";"Mevalonate pathway I";"Activation of gene expression by SREBF (SREBP)"
APLA007531-PA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
APLA004043-PA	2	Reactome: R-HSA-8964539;Reactome: R-HSA-2151201	"Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis"
APLA012150-PA	11	Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-3214847;Reactome: R-HSA-5689880;Reactome: R-HSA-167161	"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HATs acetylate histones";"Ub-specific processing proteases";"HIV Transcription Initiation"
APLA005944-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA012151-PA	13	Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
APLA007963-PA	1	Reactome: R-HSA-189451	"Heme biosynthesis"
APLA007691-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA006630-PA	2	KEGG: 00970+6.1.1.4;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
APLA012585-PA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
APLA001686-PA	16	Reactome: R-HSA-72695;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553	"Formation of the ternary complex, and subsequently, the 43S complex";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Selenocysteine synthesis";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs"
APLA007137-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6784531	"Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus"
APLA014284-PA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
APLA012085-PA	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
APLA001022-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA007656-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA011266-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA011389-PA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
APLA004101-PA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
APLA001095-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA006346-PA	5	Reactome: R-HSA-6782135;Reactome: R-HSA-5685938;Reactome: R-HSA-5696400;Reactome: R-HSA-6783310;Reactome: R-HSA-5696395	"Dual incision in TC-NER";"HDR through Single Strand Annealing (SSA)";"Dual Incision in GG-NER";"Fanconi Anemia Pathway";"Formation of Incision Complex in GG-NER"
APLA014107-PA	13	Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156902	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation"
APLA002995-PA	17	MetaCyc: PWY-7227;MetaCyc: PWY-7220;MetaCyc: PWY-7184;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7210;MetaCyc: PWY-7224;MetaCyc: PWY-7226;MetaCyc: PWY-7198;MetaCyc: PWY-7187;MetaCyc: PWY-7197;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7176;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7221;MetaCyc: PWY-7205;MetaCyc: PWY-7222;MetaCyc: PWY-6545	"Adenosine deoxyribonucleotides de novo biosynthesis";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Purine deoxyribonucleosides salvage";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine metabolism";"UTP and CTP de novo biosynthesis";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"CMP phosphorylation";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III"
APLA015344-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA007971-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA009119-PA	4	Reactome: R-HSA-5368286;Reactome: R-HSA-2514853;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Condensation of Prometaphase Chromosomes";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA002191-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA003468-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA004011-PA	7	MetaCyc: PWY-6737;MetaCyc: PWY-5941;Reactome: R-HSA-70221;MetaCyc: PWY-7238;Reactome: R-HSA-6798695;KEGG: 00500+2.4.1.25;MetaCyc: PWY-6724	"Starch degradation V";"Glycogen degradation II";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II";"Neutrophil degranulation";"Starch and sucrose metabolism";"Starch degradation II"
APLA008920-PA	2	Reactome: R-HSA-6796648;Reactome: R-HSA-6783310	"TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway"
APLA014743-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA013848-PA	4	Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
APLA013752-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA007945-PA	12	Reactome: R-HSA-982772;Reactome: R-HSA-2644606;Reactome: R-HSA-5362798;Reactome: R-HSA-75893;Reactome: R-HSA-2894862;Reactome: R-HSA-177929;Reactome: R-HSA-1442490;Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-2122948;Reactome: R-HSA-1251985;Reactome: R-HSA-193692	"Growth hormone receptor signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Release of Hh-Np from the secreting cell";"TNF signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Signaling by EGFR";"Collagen degradation";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Activated NOTCH1 Transmits Signal to the Nucleus";"Nuclear signaling by ERBB4";"Regulated proteolysis of p75NTR"
APLA002653-PA	2	Reactome: R-HSA-212676;Reactome: R-HSA-181429	"Dopamine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle"
APLA002002-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA001892-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA000428-PA	2	MetaCyc: PWY-6502;Reactome: R-HSA-2393930	"8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins"
APLA002954-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA001852-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA004373-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA003428-PA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
APLA002686-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA001904-PA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
APLA009324-PA	1	Reactome: R-HSA-912446	"Meiotic recombination"
APLA003269-PA	16	Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-1799339	"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane"
APLA000142-PA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA013500-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA013203-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA001163-PA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
APLA012599-PA	13	KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2024101;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;MetaCyc: PWY-6902;Reactome: R-HSA-2160916;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00531+3.2.1.52;MetaCyc: PWY-7883	"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"CS/DS degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Chitin degradation II (Vibrio)";"Hyaluronan uptake and degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosaminoglycan degradation";"Anhydromuropeptides recycling II"
APLA009120-PA	7	Reactome: R-HSA-163210;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2;MetaCyc: PWY-7980;Reactome: R-HSA-1268020;Reactome: R-HSA-8949613;Reactome: R-HSA-2151201	"Formation of ATP by chemiosmotic coupling";"Oxidative phosphorylation";"Photosynthesis";"ATP biosynthesis";"Mitochondrial protein import";"Cristae formation";"Transcriptional activation of mitochondrial biogenesis"
APLA005586-PA	3	Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148	"Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
APLA010397-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA013081-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
APLA008526-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA010445-PA	3	Reactome: R-HSA-6807004;Reactome: R-HSA-202427;Reactome: R-HSA-6798695	"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation"
APLA013902-PA	9	Reactome: R-HSA-69017;Reactome: R-HSA-1362277;Reactome: R-HSA-68867;Reactome: R-HSA-68689;Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68827;Reactome: R-HSA-69205;Reactome: R-HSA-68962	"CDK-mediated phosphorylation and removal of Cdc6";"Transcription of E2F targets under negative control by DREAM complex";"Assembly of the pre-replicative complex";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex";"G1/S-Specific Transcription";"Activation of the pre-replicative complex"
APLA006233-PA	4	Reactome: R-HSA-1855183;KEGG: 00562+1.13.99.1;KEGG: 00053+1.13.99.1;MetaCyc: PWY-4841	"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Ascorbate and aldarate metabolism";"UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)"
APLA001655-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA014716-PA	5	Reactome: R-HSA-390450;Reactome: R-HSA-6814122;Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-389957	"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Prefoldin mediated transfer of substrate to CCT/TriC"
APLA004793-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA010469-PA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs"
APLA010182-PA	8	Reactome: R-HSA-164378;Reactome: R-HSA-163615;Reactome: R-HSA-983231;Reactome: R-HSA-180024;Reactome: R-HSA-442720;Reactome: R-HSA-5610787;Reactome: R-HSA-432040;Reactome: R-HSA-381676	"PKA activation in glucagon signalling";"PKA activation";"Factors involved in megakaryocyte development and platelet production";"DARPP-32 events";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Hedgehog 'off' state";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"
APLA007592-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA001699-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA013578-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA009874-PA	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
APLA010783-PA	1	Reactome: R-HSA-419771	"Opsins"
APLA010851-PA	2	Reactome: R-HSA-429958;Reactome: R-HSA-390471	"mRNA decay by 3' to 5' exoribonuclease";"Association of TriC/CCT with target proteins during biosynthesis"
APLA007959-PA	5	Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-390471	"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Association of TriC/CCT with target proteins during biosynthesis"
APLA007972-PA	6	Reactome: R-HSA-8866654;Reactome: R-HSA-5632684;Reactome: R-HSA-201722;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-112382	"E3 ubiquitin ligases ubiquitinate target proteins";"Hedgehog 'on' state";"Formation of the beta-catenin:TCF transactivating complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex"
APLA001514-PA	26	Reactome: R-HSA-1989781;Reactome: R-HSA-1234158;Reactome: R-HSA-9013508;Reactome: R-HSA-1912408;Reactome: R-HSA-3371568;Reactome: R-HSA-2894862;Reactome: R-HSA-9018519;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-933541;Reactome: R-HSA-9614657;Reactome: R-HSA-8866907;Reactome: R-HSA-3214847;Reactome: R-HSA-918233;Reactome: R-HSA-9013695;Reactome: R-HSA-3134973;Reactome: R-HSA-1368082;Reactome: R-HSA-381340;Reactome: R-HSA-5621575;Reactome: R-HSA-2644606;Reactome: R-HSA-210744;Reactome: R-HSA-400253;Reactome: R-HSA-8941856;Reactome: R-HSA-3899300;Reactome: R-HSA-2122947;Reactome: R-HSA-9617629	"PPARA activates gene expression";"Regulation of gene expression by Hypoxia-inducible Factor";"NOTCH3 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"Attenuation phase";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Estrogen-dependent gene expression";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF6 mediated IRF7 activation";"FOXO-mediated transcription of cell death genes";"Activation of the TFAP2 (AP-2) family of transcription factors";"HATs acetylate histones";"TRAF3-dependent IRF activation pathway";"NOTCH4 Intracellular Domain Regulates Transcription";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"RORA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"CD209 (DC-SIGN) signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Circadian Clock";"RUNX3 regulates NOTCH signaling";"SUMOylation of transcription cofactors";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation"
APLA010151-PA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
APLA007580-PA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8869496	"Mitochondrial protein import";"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"
APLA009079-PA	18	MetaCyc: PWY-7417;MetaCyc: PWY-6803;MetaCyc: PWY-7416;Reactome: R-HSA-1482788;MetaCyc: PWY-7783;MetaCyc: PWY-8051;MetaCyc: PWY-7409;Reactome: R-HSA-1482839;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8053;Reactome: R-HSA-1482801;Reactome: R-HSA-1482925;KEGG: 00591+3.1.1.4;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482922;Reactome: R-HSA-1483166	"Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PC";"Plasmalogen degradation";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PE";"Arachidonic acid metabolism";"Ether lipid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis II";"Acyl chain remodelling of PS";"Acyl chain remodelling of PG";"Linoleic acid metabolism";"Glycerophospholipid metabolism";"Acyl chain remodelling of PI";"Synthesis of PA"
APLA009097-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA001145-PA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
APLA000951-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA000823-PA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
APLA013499-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA002383-PA	5	Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-69473;Reactome: R-HSA-5689901;Reactome: R-HSA-5693565	"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint";"Metalloprotease DUBs";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
APLA008562-PA	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
APLA005893-PA	4	Reactome: R-HSA-400511;Reactome: R-HSA-1799339;Reactome: R-HSA-381771;Reactome: R-HSA-422085	"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and deacylation of Ghrelin"
APLA012551-PA	6	Reactome: R-HSA-400253;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-2173788;Reactome: R-HSA-163560;KEGG: 05235+3.1.3.16	"Circadian Clock";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"Downregulation of TGF-beta receptor signaling";"Triglyceride catabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA012699-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA002873-PA	57	Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-8939236;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-6798695;Reactome: R-HSA-180585;Reactome: R-HSA-8852276;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5678895;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-5362768;Reactome: R-HSA-1236978;Reactome: R-HSA-75815	"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Neutrophil degranulation";"Vif-mediated degradation of APOBEC3G";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Degradation of AXIN";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Separation of Sister Chromatids";"Neddylation";"Defective CFTR causes cystic fibrosis";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D"
APLA002096-PA	7	Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25;MetaCyc: PWY-2301;MetaCyc: PWY-6363;KEGG: 00521+3.1.3.25;MetaCyc: PWY-4702;KEGG: 00562+3.1.3.25	"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Myo-inositol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Streptomycin biosynthesis";"Phytate degradation I";"Inositol phosphate metabolism"
APLA002055-PA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
APLA012417-PA	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
APLA002172-PA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.21	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
APLA005919-PA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
APLA000382-PA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
APLA015065-PA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
APLA013217-PA	5	Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-917977	"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling"
APLA001263-PA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-77387	"Neutrophil degranulation";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Ion channel transport";"Insulin receptor recycling"
APLA005540-PA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
APLA012145-PA	18	KEGG: 00350+2.6.1.1;MetaCyc: PWY-5913;MetaCyc: PWY-7117;KEGG: 00950+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00330+2.6.1.1;MetaCyc: PWY-6638;KEGG: 00250+2.6.1.1;MetaCyc: PWY-7383;KEGG: 00710+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00360+2.6.1.1;KEGG: 00270+2.6.1.1;MetaCyc: PWY-7115;KEGG: 00400+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00220+2.6.1.1;MetaCyc: PWY-6642	"Tyrosine metabolism";"Partial TCA cycle (obligate autotrophs)";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Isoquinoline alkaloid biosynthesis";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Arginine and proline metabolism";"Sulfolactate degradation III";"Alanine, aspartate and glutamate metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Carbon fixation in photosynthetic organisms";"Coenzyme M biosynthesis II";"Phenylalanine metabolism";"Cysteine and methionine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Novobiocin biosynthesis";"Arginine biosynthesis";"(R)-cysteate degradation"
APLA012976-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA015205-PA	1	Reactome: R-HSA-6803204	"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"
APLA002543-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA011992-PA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
APLA002058-PA	1	Reactome: R-HSA-8849175	"Threonine catabolism"
APLA009709-PA	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA011328-PA	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
APLA009426-PA	1	KEGG: 00531+3.2.1.35	"Glycosaminoglycan degradation"
APLA003884-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA008827-PA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
APLA003989-PA	1	Reactome: R-HSA-8949613	"Cristae formation"
APLA002486-PA	4	Reactome: R-HSA-428540;Reactome: R-HSA-4420097;Reactome: R-HSA-186763;Reactome: R-HSA-373753	"Activation of RAC1";"VEGFA-VEGFR2 Pathway";"Downstream signal transduction";"Nephrin family interactions"
APLA011260-PA	6	Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450604	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA"
APLA003536-PA	4	Reactome: R-HSA-6814122;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-112043	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events";"G-protein activation";"PLC beta mediated events"
APLA002968-PA	5	MetaCyc: PWY-7919;Reactome: R-HSA-532668;MetaCyc: PWY-7918;Reactome: R-HSA-4793954;KEGG: 00510+3.2.1.106	"Protein N-glycosylation processing phase (plants and animals)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Protein N-glycosylation processing phase (yeast)";"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-Glycan biosynthesis"
APLA000031-PA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
APLA009144-PA	3	Reactome: R-HSA-212676;Reactome: R-HSA-9609736;Reactome: R-HSA-6794361	"Dopamine Neurotransmitter Release Cycle";"Assembly and cell surface presentation of NMDA receptors";"Neurexins and neuroligins"
APLA015082-PA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
APLA011294-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA001635-PA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
APLA008681-PA	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
APLA001014-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA010637-PA	6	Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-73856;Reactome: R-HSA-111367;Reactome: R-HSA-191859;Reactome: R-HSA-77588	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Termination";"SLBP independent Processing of Histone Pre-mRNAs";"snRNP Assembly";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"
APLA011304-PA	1	Reactome: R-HSA-8949613	"Cristae formation"
APLA011531-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA011480-PA	7	KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1	"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway"
APLA006174-PA	40	MetaCyc: PWY-6946;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-7094;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7779;KEGG: 00360+4.2.1.17;MetaCyc: PWY-5789;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-7007;MetaCyc: PWY-7606;KEGG: 00640+4.2.1.17;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-7726;KEGG: 00410+4.2.1.17;MetaCyc: PWY-6583;MetaCyc: PWY-6945;KEGG: 00930+4.2.1.17+1.1.1.35;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6435;MetaCyc: PWY-7778;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-5138;MetaCyc: PWY-7654;MetaCyc: PWY-6944;MetaCyc: PWY-7656;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00592+4.2.1.17;MetaCyc: PWY-6863;MetaCyc: PWY-5109;MetaCyc: PWY-7401;MetaCyc: PWY-5136;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00623+1.1.1.35;MetaCyc: PWY-6883;MetaCyc: PWY-7216;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361	"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Fatty acid elongation";"Fatty acid salvage";"Aminobenzoate degradation";"Methyl tert-butyl ether degradation";"Phenylalanine metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Butanoate metabolism";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Propanoate metabolism";"Benzoate degradation";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"beta-Alanine metabolism";"Pyruvate fermentation to butanol I";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Caprolactam degradation";"Lysine degradation";"Limonene and pinene degradation";"4-hydroxybenzoate biosynthesis III (plants)";"2-methylpropene degradation";"Valine, leucine and isoleucine degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Androstenedione degradation";"Spodoptera littoralis pheromone biosynthesis";"Geraniol degradation";"alpha-Linolenic acid metabolism";"Pyruvate fermentation to hexanol (engineered)";"Fermentation to 2-methylbutanoate";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Fatty acid beta-oxidation II (plant peroxisome)";"Tryptophan metabolism";"Toluene degradation";"Pyruvate fermentation to butanol II (engineered)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Carbon fixation pathways in prokaryotes";"Glutaryl-coa degradation";"Fatty acid degradation";"Benzoyl-coa degradation I (aerobic)"
APLA004969-PA	6	KEGG: 00600+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23	"Sphingolipid metabolism";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
APLA008917-PA	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154;Reactome: R-HSA-445355	"Purine metabolism";"Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction"
APLA004130-PA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
APLA011797-PA	1	KEGG: 00450+1.8.1.9	"Selenocompound metabolism"
APLA009731-PA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
APLA001985-PA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
APLA003210-PA	11	Reactome: R-HSA-3371497;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-2132295;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-6807878;Reactome: R-HSA-380270;Reactome: R-HSA-6811436	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"MHC class II antigen presentation";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"COPI-mediated anterograde transport";"Recruitment of mitotic centrosome proteins and complexes";"COPI-independent Golgi-to-ER retrograde traffic"
APLA001132-PA	1	Reactome: R-HSA-5617472	"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
APLA000081-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA007670-PA	3	Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-5250924	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"B-WICH complex positively regulates rRNA expression"
APLA010883-PA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
APLA000320-PA	2	Reactome: R-HSA-6807505;Reactome: R-HSA-72163	"RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway"
APLA003633-PA	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
APLA005772-PA	2	Reactome: R-HSA-163282;Reactome: R-HSA-2151201	"Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis"
APLA000592-PA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
APLA006079-PA	16	Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
APLA003091-PA	5	KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2	"Lysine degradation";"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism"
APLA014289-PA	13	MetaCyc: PWY-5913;MetaCyc: PWY-5392;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5537;KEGG: 00660+6.2.1.5;MetaCyc: PWY-6728;Reactome: R-HSA-71403;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-6969;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;MetaCyc: PWY-7384	"Partial TCA cycle (obligate autotrophs)";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"C5-Branched dibasic acid metabolism";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Anaerobic energy metabolism (invertebrates, mitochondrial)"
APLA014377-PA	6	Reactome: R-HSA-5685938;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756	"HDR through Single Strand Annealing (SSA)";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation"
APLA012076-PA	5	KEGG: 00240+3.6.1.6;MetaCyc: PWY-7185;Reactome: R-HSA-6798695;MetaCyc: PWY-7210;KEGG: 00230+3.6.1.6	"Pyrimidine metabolism";"UTP and CTP dephosphorylation I";"Neutrophil degranulation";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Purine metabolism"
APLA013212-PA	10	MetaCyc: PWY-7921;MetaCyc: PWY-7661;Reactome: R-HSA-4719377;MetaCyc: PWY-7979;MetaCyc: PWY-7922;Reactome: R-HSA-4719360;Reactome: R-HSA-913709;Reactome: R-HSA-162699;KEGG: 00510+2.4.1.83;Reactome: R-HSA-4717374	"Protein O-mannosylation I (yeast)";"Protein N-glycosylation (Haloferax volcanii)";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"O-linked glycosylation of mucins";"Synthesis of dolichyl-phosphate mannose";"N-Glycan biosynthesis";"Defective DPM1 causes DPM1-CDG (CDG-1e)"
APLA015456-PA	17	MetaCyc: PWY-6728;MetaCyc: PWY-7115;MetaCyc: PWY-561;MetaCyc: PWY-7383;MetaCyc: PWY-6969;MetaCyc: PWY-5392;MetaCyc: PWY-1622;KEGG: 00720+1.1.1.37;MetaCyc: PWY-5913;KEGG: 00710+1.1.1.37;KEGG: 00680+1.1.1.37;KEGG: 00630+1.1.1.37;MetaCyc: PWY-5690;MetaCyc: PWY-8086;KEGG: 00270+1.1.1.37;KEGG: 00620+1.1.1.37;KEGG: 00020+1.1.1.37	"Methylaspartate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Superpathway of glyoxylate cycle and fatty acid degradation";"Anaerobic energy metabolism (invertebrates, cytosol)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"Formaldehyde assimilation I (serine pathway)";"Carbon fixation pathways in prokaryotes";"Partial TCA cycle (obligate autotrophs)";"Carbon fixation in photosynthetic organisms";"Methane metabolism";"Glyoxylate and dicarboxylate metabolism";"TCA cycle II (plants and fungi)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Cysteine and methionine metabolism";"Pyruvate metabolism";"Citrate cycle (TCA cycle)"
APLA013073-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA000900-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA004306-PA	3	KEGG: 00250+3.5.1.1;KEGG: 00460+3.5.1.1;Reactome: R-HSA-8964208	"Alanine, aspartate and glutamate metabolism";"Cyanoamino acid metabolism";"Phenylalanine metabolism"
APLA000454-PA	10	Reactome: R-HSA-9636383;Reactome: R-HSA-432720;Reactome: R-HSA-182971;Reactome: R-HSA-6807004;Reactome: R-HSA-5689880;Reactome: R-HSA-917729;Reactome: R-HSA-8856825;Reactome: R-HSA-8875360;Reactome: R-HSA-9635644;Reactome: R-HSA-8856828	"Prevention of phagosomal-lysosomal fusion";"Lysosome Vesicle Biogenesis";"EGFR downregulation";"Negative regulation of MET activity";"Ub-specific processing proteases";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Cargo recognition for clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Inhibition of membrane repair";"Clathrin-mediated endocytosis"
APLA014850-PA	26	Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-6811434;Reactome: R-HSA-8955332;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-6811436;Reactome: R-HSA-437239;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-389977;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-389960;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-983189	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"COPI-dependent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"COPI-independent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Separation of Sister Chromatids";"Aggrephagy";"Post-chaperonin tubulin folding pathway";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Gap junction assembly";"HCMV Early Events";"Formation of tubulin folding intermediates by CCT/TriC";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Cilium Assembly";"COPI-mediated anterograde transport";"Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Kinesins"
APLA010644-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA015204-PA	3	Reactome: R-HSA-140837;Reactome: R-HSA-9645722;Reactome: R-HSA-111471	"Intrinsic Pathway of Fibrin Clot Formation";"Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function";"Apoptotic factor-mediated response"
APLA013070-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA005704-PA	52	Reactome: R-HSA-69017;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5678895;Reactome: R-HSA-1236974;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-4608870;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-450408;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-8939236	"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Neddylation";"Separation of Sister Chromatids";"Defective CFTR causes cystic fibrosis";"ER-Phagosome pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Asymmetric localization of PCP proteins";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"Degradation of AXIN";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
APLA000510-PA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
APLA013060-PA	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
APLA011913-PA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
APLA003882-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA004656-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA009518-PA	5	Reactome: R-HSA-159236;Reactome: R-HSA-73856;KEGG: 00480+3.4.11.1;Reactome: R-HSA-72163;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"Glutathione metabolism";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing"
APLA006973-PA	3	KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2;MetaCyc: PWY-7980	"Oxidative phosphorylation";"Photosynthesis";"ATP biosynthesis"
APLA011781-PA	2	KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I"
APLA000590-PA	4	KEGG: 00480+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00270+2.5.1.16;KEGG: 00330+2.5.1.16	"Glutathione metabolism";"Metabolism of polyamines";"Cysteine and methionine metabolism";"Arginine and proline metabolism"
APLA008949-PA	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
APLA011921-PA	6	KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107	"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism"
APLA000807-PA	3	Reactome: R-HSA-72163;Reactome: R-HSA-430039;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Minor Pathway"
APLA001937-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA003710-PA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
APLA001451-PA	13	KEGG: 04926+2.7.11.1;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6802948;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6802946;Reactome: R-HSA-5674135;KEGG: 05170+2.7.11.1;Reactome: R-HSA-9649948	"Relaxin signaling pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Signaling by high-kinase activity BRAF mutants";"Human cytomegalovirus infection";"Human papillomavirus infection";"Signaling by moderate kinase activity BRAF mutants";"MAP2K and MAPK activation";"Human immunodeficiency virus 1 infection";"Signaling downstream of RAS mutants"
APLA002859-PA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-68877	"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Mitotic Prometaphase"
APLA003040-PA	3	MetaCyc: PWY-7999;Reactome: R-HSA-159740;KEGG: 00130+4.1.1.90	"Vitamin K-epoxide cycle";"Gamma-carboxylation of protein precursors";"Ubiquinone and other terpenoid-quinone biosynthesis"
APLA013079-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA011701-PA	4	Reactome: R-HSA-72731;MetaCyc: PWY-7174;MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23	"Recycling of eIF2:GDP";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism"
APLA004524-PA	2	Reactome: R-HSA-983168;Reactome: R-HSA-110320	"Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH"
APLA010274-PA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
APLA000324-PA	1	Reactome: R-HSA-71288	"Creatine metabolism"
APLA008561-PA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
APLA011005-PA	16	Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-141430;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-176412;Reactome: R-HSA-2559582;Reactome: R-HSA-174184;Reactome: R-HSA-174048;Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-176407;Reactome: R-HSA-69017;Reactome: R-HSA-176408	"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"Phosphorylation of the APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Cyclin B";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of APC/C activators between G1/S and early anaphase"
APLA009224-PA	2	KEGG: 00970+6.1.1.11;MetaCyc: PWY-6281	"Aminoacyl-tRNA biosynthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)"
APLA001478-PA	9	Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-6804756;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-73776	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Transcription of the HIV genome";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape"
APLA013466-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA012616-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA006185-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA009642-PA	10	Reactome: R-HSA-3299685;Reactome: R-HSA-111459;Reactome: R-HSA-9627069;Reactome: R-HSA-611105;Reactome: R-HSA-111457;Reactome: R-HSA-2151201;Reactome: R-HSA-111458;Reactome: R-HSA-111463;Reactome: R-HSA-5628897;Reactome: R-HSA-111464	"Detoxification of Reactive Oxygen Species";"Activation of caspases through apoptosome-mediated cleavage";"Regulation of the apoptosome activity";"Respiratory electron transport";"Release of apoptotic factors from the mitochondria";"Transcriptional activation of mitochondrial biogenesis";"Formation of apoptosome";"SMAC (DIABLO) binds to IAPs";"TP53 Regulates Metabolic Genes";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes"
APLA008116-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA000130-PA	16	Reactome: R-HSA-72695;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"Formation of the ternary complex, and subsequently, the 43S complex";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
APLA014601-PA	8	Reactome: R-HSA-9613354;Reactome: R-HSA-9619483;Reactome: R-HSA-2151209;Reactome: R-HSA-1445148;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-6804756	"Lipophagy";"Activation of AMPK downstream of NMDARs";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Macroautophagy";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of TP53 Activity through Phosphorylation"
APLA011326-PA	2	Reactome: R-HSA-70350;Reactome: R-HSA-168928	"Fructose catabolism";"DDX58/IFIH1-mediated induction of interferon-alpha/beta"
APLA001653-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA008023-PA	3	KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9;Reactome: R-HSA-5368286	"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"Mitochondrial translation initiation"
APLA013076-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA012199-PA	2	Reactome: R-HSA-203927;Reactome: R-HSA-426486	"MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis"
APLA006684-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA013770-PA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
APLA000316-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA002644-PA	1	Reactome: R-HSA-71064	"Lysine catabolism"
APLA008930-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA009375-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA010011-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA001690-PA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
APLA010641-PA	2	Reactome: R-HSA-5673001;Reactome: R-HSA-8853659	"RAF/MAP kinase cascade";"RET signaling"
APLA004698-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA004532-PA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-450604	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA"
APLA002042-PA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
APLA006681-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA013309-PA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-450604	"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA"
APLA013710-PA	3	KEGG: 00030+2.7.6.1;Reactome: R-HSA-73843;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"5-Phosphoribose 1-diphosphate biosynthesis";"Purine metabolism"
APLA011092-PA	3	MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646	"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification"
APLA015017-PA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
APLA012012-PA	3	Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148	"Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
APLA003519-PA	7	Reactome: R-HSA-6798695;KEGG: 00230+1.1.1.205;KEGG: 00983+1.1.1.205;MetaCyc: PWY-5695;Reactome: R-HSA-73817;MetaCyc: PWY-7221;MetaCyc: PWY-6596	"Neutrophil degranulation";"Purine metabolism";"Drug metabolism - other enzymes";"Inosine 5'-phosphate degradation";"Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Adenosine nucleotides degradation I"
APLA013284-PA	2	KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336	"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway"
APLA006305-PA	11	Reactome: R-HSA-6785631;Reactome: R-HSA-8863795;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993;Reactome: R-HSA-5673001;Reactome: R-HSA-1963642;Reactome: R-HSA-9664565;Reactome: R-HSA-1250196;Reactome: R-HSA-6811558;Reactome: R-HSA-2219530;Reactome: R-HSA-1227986	"ERBB2 Regulates Cell Motility";"Downregulation of ERBB2 signaling";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling";"RAF/MAP kinase cascade";"PI3K events in ERBB2 signaling";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Signaling by ERBB2"
APLA002352-PA	3	MetaCyc: PWY-7285;MetaCyc: PWY-7286;MetaCyc: PWY-6829	"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Trna methylation (yeast)"
APLA007911-PA	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
APLA010998-PA	5	MetaCyc: PWY-6906;Reactome: R-HSA-70171;MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6;MetaCyc: PWY-5514	"Chitin derivatives degradation";"Glycolysis";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis II"
APLA009923-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA011305-PA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
APLA005470-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA001600-PA	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
APLA011722-PA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
APLA010018-PA	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
APLA012410-PA	6	MetaCyc: PWY-7426;KEGG: 00513+2.4.1.143;Reactome: R-HSA-975578;MetaCyc: PWY-7920;Reactome: R-HSA-4793952;KEGG: 00510+2.4.1.143	"Complex N-linked glycan biosynthesis (vertebrates)";"Various types of N-glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (plants)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"N-Glycan biosynthesis"
APLA013678-PA	3	MetaCyc: PWY-6829;MetaCyc: PWY-7285;MetaCyc: PWY-7286	"Trna methylation (yeast)";"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis"
APLA008103-PA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
APLA014913-PA	3	Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621	"Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism"
APLA009443-PA	1	Reactome: R-HSA-381038	"XBP1(S) activates chaperone genes"
APLA000032-PA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
APLA000317-PA	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
APLA012033-PA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
APLA011973-PA	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
APLA009873-PA	4	Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;Reactome: R-HSA-382556;Reactome: R-HSA-5678895	"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis"
APLA015322-PA	4	Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
APLA013950-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA000398-PA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA010056-PA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
APLA010033-PA	7	KEGG: 00562+2.7.8.11;MetaCyc: PWY-6351;KEGG: 04070+2.7.8.11;MetaCyc: PWY-6352;Reactome: R-HSA-1483226;MetaCyc: PWY-7625;KEGG: 00564+2.7.8.11	"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system";"3-phosphoinositide biosynthesis";"Synthesis of PI";"Phosphatidylinositol biosynthesis II (eukaryotes)";"Glycerophospholipid metabolism"
APLA003229-PA	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
APLA008555-PA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
APLA014142-PA	1	Reactome: R-HSA-5368286	"Mitochondrial translation initiation"
APLA008768-PA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
APLA003197-PA	1	Reactome: R-HSA-6793080	"rRNA modification in the mitochondrion"
APLA005959-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA012406-PA	13	Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5358606;Reactome: R-HSA-5685938;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5358565;Reactome: R-HSA-5689880;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-3214847;Reactome: R-HSA-6804756	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Ub-specific processing proteases";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"HATs acetylate histones";"Regulation of TP53 Activity through Phosphorylation"
APLA012321-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA010419-PA	2	Reactome: R-HSA-5689880;MetaCyc: PWY-7511	"Ub-specific processing proteases";"Protein ubiquitination"
APLA004543-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA000777-PA	5	Reactome: R-HSA-6811555;Reactome: R-HSA-6804756;Reactome: R-HSA-936440;Reactome: R-HSA-1169408;Reactome: R-HSA-5668599	"PI5P Regulates TP53 Acetylation";"Regulation of TP53 Activity through Phosphorylation";"Negative regulators of DDX58/IFIH1 signaling";"ISG15 antiviral mechanism";"RHO GTPases Activate NADPH Oxidases"
APLA009758-PA	8	Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-3371571;Reactome: R-HSA-8943724	"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTORC1-mediated signalling";"Amino acids regulate mTORC1";"mTOR signalling";"HSF1-dependent transactivation";"Regulation of PTEN gene transcription"
APLA001313-PA	56	Reactome: R-HSA-8939236;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-1236974;Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-349425	"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway";"Defective CFTR causes cystic fibrosis";"Neddylation";"Separation of Sister Chromatids";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1"
APLA005498-PA	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
APLA007612-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA000788-PA	6	MetaCyc: PWY-5514;KEGG: 00030+3.1.1.31;MetaCyc: PWY-8004;KEGG: 00520+3.5.99.6;MetaCyc: PWY-6906;MetaCyc: PWY-6855	"UDP-N-acetyl-D-galactosamine biosynthesis II";"Pentose phosphate pathway";"Entner-Doudoroff pathway I";"Amino sugar and nucleotide sugar metabolism";"Chitin derivatives degradation";"Chitin degradation I (archaea)"
APLA007545-PA	1	Reactome: R-HSA-211981	"Xenobiotics"
APLA004752-PA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
APLA001973-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA003914-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA001407-PA	6	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-917729;Reactome: R-HSA-9610379;Reactome: R-HSA-2644606	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
APLA002640-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA001952-PA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
APLA015433-PA	14	MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7725;MetaCyc: PWY-8041	"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis"
APLA010600-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA014006-PA	2	Reactome: R-HSA-68962;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress"
APLA010313-PA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-9020702	"Neutrophil degranulation";"Interleukin-1 signaling"
APLA005378-PA	18	KEGG: 00270+1.1.1.37;KEGG: 00020+1.1.1.37;KEGG: 00620+1.1.1.37;MetaCyc: PWY-5690;MetaCyc: PWY-8086;KEGG: 00630+1.1.1.37;KEGG: 00680+1.1.1.37;KEGG: 00710+1.1.1.37;MetaCyc: PWY-5913;MetaCyc: PWY-5392;MetaCyc: PWY-1622;KEGG: 00720+1.1.1.37;MetaCyc: PWY-6969;Reactome: R-HSA-70263;MetaCyc: PWY-7383;MetaCyc: PWY-561;MetaCyc: PWY-7115;MetaCyc: PWY-6728	"Cysteine and methionine metabolism";"Citrate cycle (TCA cycle)";"Pyruvate metabolism";"TCA cycle II (plants and fungi)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Glyoxylate and dicarboxylate metabolism";"Methane metabolism";"Carbon fixation in photosynthetic organisms";"Partial TCA cycle (obligate autotrophs)";"Reductive TCA cycle II";"Formaldehyde assimilation I (serine pathway)";"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Superpathway of glyoxylate cycle and fatty acid degradation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Methylaspartate cycle"
APLA012856-PA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
APLA001574-PA	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
APLA002381-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA005337-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA009728-PA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
APLA005272-PA	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
APLA008984-PA	4	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-8866654	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins"
APLA012306-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA001410-PA	3	Reactome: R-HSA-392154;Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2	"Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction";"Purine metabolism"
APLA007705-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA008080-PA	13	Reactome: R-HSA-3928663;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5627117;Reactome: R-HSA-3928662;Reactome: R-HSA-416572;KEGG: 04926+2.7.11.1;Reactome: R-HSA-416482;KEGG: 05165+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1	"EPHA-mediated growth cone collapse";"Thermogenesis";"mTOR signaling pathway";"RHO GTPases Activate ROCKs";"EPHB-mediated forward signaling";"Sema4D induced cell migration and growth-cone collapse";"Relaxin signaling pathway";"G alpha (12/13) signalling events";"Human papillomavirus infection";"VEGFA-VEGFR2 Pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection"
APLA003169-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA008643-PA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
APLA008300-PA	3	Reactome: R-HSA-6782315;MetaCyc: PWY-6700;MetaCyc: PWY-8106	"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis I (de novo)";"Queuosine biosynthesis III (queuosine salvage)"
APLA000606-PA	5	Reactome: R-HSA-2644606;Reactome: R-HSA-3214815;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"HDACs deacetylate histones";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
APLA003096-PA	7	MetaCyc: PWY-6840;Reactome: R-HSA-174403;KEGG: 00480+6.3.2.2;Reactome: R-HSA-5578999;MetaCyc: PWY-8043;KEGG: 00270+6.3.2.2;MetaCyc: PWY-7255	"Homoglutathione biosynthesis";"Glutathione synthesis and recycling";"Glutathione metabolism";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Ophthalmate biosynthesis";"Cysteine and methionine metabolism";"Ergothioneine biosynthesis I (bacteria)"
APLA014253-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA004184-PA	6	Reactome: R-HSA-9615017;Reactome: R-HSA-6798695;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6	"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Neutrophil degranulation";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism"
APLA012208-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA010716-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA006976-PA	3	MetaCyc: PWY-7980;KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2	"ATP biosynthesis";"Photosynthesis";"Oxidative phosphorylation"
APLA008224-PA	1	Reactome: R-HSA-2028269	"Signaling by Hippo"
APLA003714-PA	3	Reactome: R-HSA-189451;KEGG: 00860+2.5.1.141;MetaCyc: PWY-7856	"Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"Heme a biosynthesis"
APLA012840-PA	10	Reactome: R-HSA-6798695;Reactome: R-HSA-8939243;Reactome: R-HSA-201688;Reactome: R-HSA-8948751;Reactome: R-HSA-6814122;Reactome: R-HSA-8934903;Reactome: R-HSA-445144;Reactome: R-HSA-1483191;Reactome: R-HSA-2514853;Reactome: R-HSA-6804756	"Neutrophil degranulation";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"WNT mediated activation of DVL";"Regulation of PTEN stability and activity";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Receptor Mediated Mitophagy";"Signal transduction by L1";"Synthesis of PC";"Condensation of Prometaphase Chromosomes";"Regulation of TP53 Activity through Phosphorylation"
APLA005648-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA002451-PA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
APLA004965-PA	4	Reactome: R-HSA-2214320;Reactome: R-HSA-2243919;Reactome: R-HSA-1650814;Reactome: R-HSA-1474228	"Anchoring fibril formation";"Crosslinking of collagen fibrils";"Collagen biosynthesis and modifying enzymes";"Degradation of the extracellular matrix"
APLA012605-PA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
APLA012536-PA	9	MetaCyc: PWY-8052;Reactome: R-HSA-112043;MetaCyc: PWY-7039;MetaCyc: PWY-6351;KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204;MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;Reactome: R-HSA-416476	"2-arachidonoylglycerol biosynthesis";"PLC beta mediated events";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"G alpha (q) signalling events"
APLA003037-PA	11	Reactome: R-HSA-163615;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-164378;Reactome: R-HSA-170670;Reactome: R-HSA-432040;Reactome: R-HSA-418597;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-5610787	"PKA activation";"G alpha (i) signalling events";"Purine metabolism";"Adenylate cyclase activating pathway";"PKA activation in glucagon signalling";"Adenylate cyclase inhibitory pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"Hedgehog 'off' state"
APLA011346-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA001070-PA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
APLA010127-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA008083-PA	3	Reactome: R-HSA-379726;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.14	"Mitochondrial tRNA aminoacylation";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
APLA001914-PA	3	Reactome: R-HSA-189451;MetaCyc: PWY-7159;KEGG: 00860+1.3.3.4	"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism"
APLA013281-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA012594-PA	7	Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-76071	"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter"
APLA000830-PA	7	Reactome: R-HSA-5696394;Reactome: R-HSA-2173795;Reactome: R-HSA-5696395;Reactome: R-HSA-3108214;Reactome: R-HSA-5696400;Reactome: R-HSA-110362;Reactome: R-HSA-5685939	"DNA Damage Recognition in GG-NER";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Formation of Incision Complex in GG-NER";"SUMOylation of DNA damage response and repair proteins";"Dual Incision in GG-NER";"POLB-Dependent Long Patch Base Excision Repair";"HDR through MMEJ (alt-NHEJ)"
APLA006461-PA	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
APLA001860-PA	3	Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621	"Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism"
APLA008770-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA010776-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA011093-PA	3	MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646	"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification"
APLA007811-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA003217-PA	13	Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-975956	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
APLA013711-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA014069-PA	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
APLA012869-PA	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
APLA011613-PA	4	Reactome: R-HSA-8951664;Reactome: R-HSA-5676590;Reactome: R-HSA-983168;Reactome: R-HSA-5607761	"Neddylation";"NIK-->noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling"
APLA008504-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA013338-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
APLA000810-PA	56	Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-174178;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780;Reactome: R-HSA-5607764;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-180534;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5678895;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751	"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Degradation of AXIN";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome";"CLEC7A (Dectin-1) signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"Vpu mediated degradation of CD4";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Defective CFTR causes cystic fibrosis";"Separation of Sister Chromatids";"Neddylation";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity"
APLA000366-PA	8	Reactome: R-HSA-73614;MetaCyc: PWY-6556;Reactome: R-HSA-6798695;MetaCyc: PWY-7193;MetaCyc: PWY-7181;KEGG: 00240+3.5.4.5;KEGG: 00983+3.5.4.5;MetaCyc: PWY-7199	"Pyrimidine salvage";"Pyrimidine ribonucleosides salvage II";"Neutrophil degranulation";"Pyrimidine ribonucleosides salvage I";"Pyrimidine deoxyribonucleosides degradation";"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleosides salvage"
APLA004314-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA008066-PA	1	Reactome: R-HSA-6804754	"Regulation of TP53 Expression"
APLA000266-PA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
APLA006367-PA	3	Reactome: R-HSA-450604;Reactome: R-HSA-429947;Reactome: R-HSA-380994	"KSRP (KHSRP) binds and destabilizes mRNA";"Deadenylation of mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress"
APLA012118-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA004625-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA015371-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA005195-PA	5	Reactome: R-HSA-162588;Reactome: R-HSA-174490;Reactome: R-HSA-917729;Reactome: R-HSA-9610379;Reactome: R-HSA-9615710	"Budding and maturation of HIV virion";"Membrane binding and targetting of GAG proteins";"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events";"Late endosomal microautophagy"
APLA003226-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA010347-PA	56	Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-8852276;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-8939236;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5678895;Reactome: R-HSA-1236974;Reactome: R-HSA-5362768;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-180534;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-5607764	"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of AXIN";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Separation of Sister Chromatids";"Neddylation";"Defective CFTR causes cystic fibrosis";"ER-Phagosome pathway";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"CLEC7A (Dectin-1) signaling"
APLA008838-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA006563-PA	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
APLA014103-PA	3	Reactome: R-HSA-1614558;Reactome: R-HSA-1614603;Reactome: R-HSA-2408508	"Degradation of cysteine and homocysteine";"Cysteine formation from homocysteine";"Metabolism of ingested SeMet, Sec, MeSec into H2Se"
APLA000397-PA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
APLA012413-PA	2	Reactome: R-HSA-8862803;Reactome: R-HSA-69273	"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Cyclin A/B1/B2 associated events during G2/M transition"
APLA009677-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA008014-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA006664-PA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
APLA012909-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA004868-PA	3	Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-430039	"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease"
APLA013331-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA013952-PA	11	Reactome: R-HSA-3560801;Reactome: R-HSA-1971475;Reactome: R-HSA-202733;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253;Reactome: R-HSA-3560783;Reactome: R-HSA-3000170;Reactome: R-HSA-4420332;Reactome: R-HSA-975634;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096	"Defective B3GAT3 causes JDSSDHD";"A tetrasaccharide linker sequence is required for GAG synthesis";"Cell surface interactions at the vascular wall";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective B4GALT7 causes EDS, progeroid type";"Syndecan interactions";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Retinoid metabolism and transport";"Defective EXT2 causes exostoses 2";"HS-GAG degradation"
APLA005283-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA008850-PA	9	MetaCyc: PWY-7115;MetaCyc: PWY-5789;MetaCyc: PWY-6142;MetaCyc: PWY-5743;MetaCyc: PWY-241;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7117;MetaCyc: PWY-5744;Reactome: R-HSA-1475029	"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"Reversible hydration of carbon dioxide"
APLA008538-PA	1	Reactome: R-HSA-8943724	"Regulation of PTEN gene transcription"
APLA005545-PA	20	KEGG: 04926+2.7.11.1;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-1257604;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;KEGG: 04151+2.7.11.1;Reactome: R-HSA-8943724;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-3371571;Reactome: R-HSA-166208;Reactome: R-HSA-6804757;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1	"Relaxin signaling pathway";"mTOR signalling";"Amino acids regulate mTORC1";"PIP3 activates AKT signaling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Macroautophagy";"PI3K-Akt signaling pathway";"Regulation of PTEN gene transcription";"Human cytomegalovirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"CD28 dependent PI3K/Akt signaling";"HSF1-dependent transactivation";"mTORC1-mediated signalling";"Regulation of TP53 Degradation";"mTOR signaling pathway";"Thermogenesis"
APLA004032-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA000357-PA	14	MetaCyc: PWY-3781;KEGG: 00190+1.3.5.1;KEGG: 00020+1.3.5.1;MetaCyc: PWY-7254;Reactome: R-HSA-611105;MetaCyc: PWY-6969;KEGG: 00720+1.3.5.1;MetaCyc: PWY-5690;KEGG: 00650+1.3.5.1;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-561;MetaCyc: PWY-4302;MetaCyc: PWY-7279	"Aerobic respiration I (cytochrome c)";"Oxidative phosphorylation";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Respiratory electron transport";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Butanoate metabolism";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration III (alternative oxidase pathway)";"Aerobic respiration II (cytochrome c) (yeast)"
APLA011268-PA	1	MetaCyc: PWY-6938	"NADH repair"
APLA002520-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA007558-PA	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
APLA002390-PA	8	Reactome: R-HSA-68689;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68616;Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68949;Reactome: R-HSA-68962	"CDC6 association with the ORC:origin complex";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication";"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Orc1 removal from chromatin";"Activation of the pre-replicative complex"
APLA004070-PA	1	Reactome: R-HSA-525793	"Myogenesis"
APLA003381-PA	1	Reactome: R-HSA-4419969	"Depolymerisation of the Nuclear Lamina"
APLA009000-PA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
APLA011983-PA	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
APLA004094-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA012467-PA	4	Reactome: R-HSA-936837;Reactome: R-HSA-1912420;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Ion transport by P-type ATPases";"Pre-NOTCH Processing in Golgi";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
APLA003266-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA014441-PA	2	Reactome: R-HSA-72706;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition"
APLA014007-PA	7	KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis"
APLA007481-PA	1	Reactome: R-HSA-71064	"Lysine catabolism"
APLA006453-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA011104-PA	3	Reactome: R-HSA-2142691;MetaCyc: PWY-7533;Reactome: R-HSA-5423646	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis";"Aflatoxin activation and detoxification"
APLA006221-PA	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
APLA001323-PA	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
APLA006988-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA001388-PA	6	Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-176974	"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA"
APLA000552-PA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
APLA004527-PA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
APLA014769-PA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
APLA001446-PA	3	KEGG: 00230+2.7.1.20;MetaCyc: PWY-6619;Reactome: R-HSA-74217	"Purine metabolism";"Adenine and adenosine salvage VI";"Purine salvage"
APLA001647-PA	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
APLA009515-PA	7	MetaCyc: PWY-6470;Reactome: R-HSA-5633231;MetaCyc: PWY-5265;Reactome: R-HSA-446193;MetaCyc: PWY-6385;KEGG: 00550+2.4.1.227;MetaCyc: PWY-6471	"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Peptidoglycan biosynthesis II (staphylococci)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis III (mycobacteria)";"Peptidoglycan biosynthesis";"Peptidoglycan biosynthesis IV (Enterococcus faecium)"
APLA014391-PA	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
APLA008108-PA	32	Reactome: R-HSA-6807505;Reactome: R-HSA-6796648;Reactome: R-HSA-72165;Reactome: R-HSA-167242;Reactome: R-HSA-167238;Reactome: R-HSA-9018519;Reactome: R-HSA-167290;Reactome: R-HSA-8851708;Reactome: R-HSA-72163;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-167160;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-72203;Reactome: R-HSA-167161;Reactome: R-HSA-168325;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-6803529	"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Splicing - Minor Pathway";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Estrogen-dependent gene expression";"Pausing and recovery of HIV elongation";"Signaling by FGFR2 IIIa TM";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA";"HIV Transcription Initiation";"Viral Messenger RNA Synthesis";"mRNA Capping";"Formation of the Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"FGFR2 alternative splicing"
APLA002332-PA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
APLA012186-PA	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA003087-PA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
APLA008686-PA	57	Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-8852276;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-6798695;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5678895;Reactome: R-HSA-180534;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-5610780;Reactome: R-HSA-202424;Reactome: R-HSA-5676590	"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Degradation of AXIN";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"Neutrophil degranulation";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Separation of Sister Chromatids";"Neddylation";"Defective CFTR causes cystic fibrosis";"Vpu mediated degradation of CD4";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"Degradation of GLI1 by the proteasome";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling"
APLA004280-PA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
APLA001077-PA	1	MetaCyc: PWY-7437	"Protein O-[N-acetyl]-glucosylation"
APLA010136-PA	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
APLA014519-PA	6	Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-389957;Reactome: R-HSA-5620922	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Prefoldin mediated transfer of substrate to CCT/TriC";"BBSome-mediated cargo-targeting to cilium"
APLA000839-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA003891-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA014998-PA	26	Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-983189;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-389960;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-9619483;Reactome: R-HSA-5617833;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-6811436;Reactome: R-HSA-437239;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-389977;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-8955332	"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Kinesins";"HCMV Early Events";"Gap junction assembly";"Formation of tubulin folding intermediates by CCT/TriC";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Activation of AMPK downstream of NMDARs";"Cilium Assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Separation of Sister Chromatids";"Aggrephagy";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"Post-chaperonin tubulin folding pathway";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Carboxyterminal post-translational modifications of tubulin"
APLA001625-PA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
APLA010276-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA000539-PA	6	MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;Reactome: R-HSA-9640463	"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis"
APLA003168-PA	4	MetaCyc: PWY-7382;Reactome: R-HSA-389661;MetaCyc: PWY-6987;KEGG: 00785+2.8.1.8	"Lipoate biosynthesis and incorporation IV (yeast)";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism"
APLA012089-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA000950-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA005614-PA	7	KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway"
APLA001863-PA	1	Reactome: R-HSA-9640463	"Wax biosynthesis"
APLA002423-PA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
APLA004191-PA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
APLA013883-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA003046-PA	52	Reactome: R-HSA-72165;Reactome: R-HSA-73780;Reactome: R-HSA-6782210;Reactome: R-HSA-749476;Reactome: R-HSA-6781827;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648;Reactome: R-HSA-73772;Reactome: R-HSA-5617472;Reactome: R-HSA-167238;Reactome: R-HSA-9018519;Reactome: R-HSA-76066;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-167242;Reactome: R-HSA-73762;Reactome: R-HSA-6782135;Reactome: R-HSA-73980;Reactome: R-HSA-167246;Reactome: R-HSA-76061;Reactome: R-HSA-75955;Reactome: R-HSA-5601884;Reactome: R-HSA-77075;Reactome: R-HSA-8851708;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-72163;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-203927;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-5578749;Reactome: R-HSA-75953;Reactome: R-HSA-6803529;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-5250924;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-73863;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-167161	"mRNA Splicing - Minor Pathway";"RNA Polymerase III Chain Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase III Abortive And Retractive Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Promoter Escape";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Pausing and recovery of Tat-mediated HIV elongation";"Estrogen-dependent gene expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase I Transcription Initiation";"Dual incision in TC-NER";"RNA Polymerase III Transcription Termination";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase II Transcription Elongation";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"mRNA Splicing - Major Pathway";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"MicroRNA (miRNA) biogenesis";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Transcriptional regulation by small RNAs";"RNA Polymerase II Transcription Initiation";"FGFR2 alternative splicing";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"B-WICH complex positively regulates rRNA expression";"mRNA Capping";"Formation of the Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"RNA Polymerase I Transcription Termination";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation"
APLA007722-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA005862-PA	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
APLA008742-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA009207-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA007823-PA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA001549-PA	2	Reactome: R-HSA-8876725;Reactome: R-HSA-611105	"Protein methylation";"Respiratory electron transport"
APLA004905-PA	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
APLA014272-PA	182	Reactome: R-HSA-5675221;Reactome: R-HSA-8876493;Reactome: R-HSA-72649;Reactome: R-HSA-174084;Reactome: R-HSA-5689877;Reactome: R-HSA-2173791;Reactome: R-HSA-5689880;Reactome: R-HSA-937039;Reactome: R-HSA-1236382;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5696395;Reactome: R-HSA-400253;Reactome: R-HSA-9604323;Reactome: R-HSA-2559585;Reactome: R-HSA-110320;Reactome: R-HSA-174184;Reactome: R-HSA-3134975;Reactome: R-HSA-5689896;Reactome: R-HSA-975957;Reactome: R-HSA-69541;Reactome: R-HSA-1236974;Reactome: R-HSA-72706;Reactome: R-HSA-5654732;Reactome: R-HSA-2565942;Reactome: R-HSA-450408;Reactome: R-HSA-532668;Reactome: R-HSA-5610785;Reactome: R-HSA-2173795;Reactome: R-HSA-5654727;Reactome: R-HSA-5658442;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-6781823;Reactome: R-HSA-5656121;Reactome: R-HSA-168928;Reactome: R-HSA-6782135;Reactome: R-HSA-182971;Reactome: R-HSA-2691232;Reactome: R-HSA-5675482;Reactome: R-HSA-937041;Reactome: R-HSA-2122948;Reactome: R-HSA-2408557;Reactome: R-HSA-9637628;Reactome: R-HSA-2672351;Reactome: R-HSA-168927;Reactome: R-HSA-937072;Reactome: R-HSA-975163;Reactome: R-HSA-5656169;Reactome: R-HSA-68827;Reactome: R-HSA-9613829;Reactome: R-HSA-2871837;Reactome: R-HSA-6807004;Reactome: R-HSA-9013507;Reactome: R-HSA-4641263;Reactome: R-HSA-175474;Reactome: R-HSA-2559580;Reactome: R-HSA-8852276;Reactome: R-HSA-205043;Reactome: R-HSA-5693607;Reactome: R-HSA-1169408;Reactome: R-HSA-912631;Reactome: R-HSA-72702;Reactome: R-HSA-8939236;Reactome: R-HSA-72695;Reactome: R-HSA-450321;Reactome: R-HSA-168638;Reactome: R-HSA-5632684;Reactome: R-HSA-162588;Reactome: R-HSA-9636383;Reactome: R-HSA-5696394;Reactome: R-HSA-4608870;Reactome: R-HSA-1253288;Reactome: R-HSA-5357956;Reactome: R-HSA-9020702;Reactome: R-HSA-9645460;Reactome: R-HSA-8948751;Reactome: R-HSA-192823;Reactome: R-HSA-1358803;Reactome: R-HSA-5684264;Reactome: R-HSA-1295596;Reactome: R-HSA-9013973;Reactome: R-HSA-8863795;Reactome: R-HSA-202424;Reactome: R-HSA-3785653;Reactome: R-HSA-975956;Reactome: R-HSA-174113;Reactome: R-HSA-5693565;Reactome: R-HSA-3769402;Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-8866654;Reactome: R-HSA-8854050;Reactome: R-HSA-156827;Reactome: R-HSA-5610783;Reactome: R-HSA-5357905;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-6783310;Reactome: R-HSA-180585;Reactome: R-HSA-975110;Reactome: R-HSA-6782210;Reactome: R-HSA-2173788;Reactome: R-HSA-8866652;Reactome: R-HSA-450302;Reactome: R-HSA-8875360;Reactome: R-HSA-2559582;Reactome: R-HSA-9014325;Reactome: R-HSA-6791226;Reactome: R-HSA-6781827;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-5696397;Reactome: R-HSA-174048;Reactome: R-HSA-5655862;Reactome: R-HSA-69017;Reactome: R-HSA-5685942;Reactome: R-HSA-1799339;Reactome: R-HSA-5205685;Reactome: R-HSA-2979096;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-8951664;Reactome: R-HSA-72689;Reactome: R-HSA-5654726;Reactome: R-HSA-211733;Reactome: R-HSA-9633012;Reactome: R-HSA-180534;Reactome: R-HSA-69231;Reactome: R-HSA-174154;Reactome: R-HSA-110312;Reactome: R-HSA-2173796;Reactome: R-HSA-187577;Reactome: R-HSA-5654733;Reactome: R-HSA-5689901;Reactome: R-HSA-382556;Reactome: R-HSA-8856828;Reactome: R-HSA-917937;Reactome: R-HSA-69601;Reactome: R-HSA-2894862;Reactome: R-HSA-6804760;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-6804757;Reactome: R-HSA-72764;Reactome: R-HSA-110314;Reactome: R-HSA-9033241;Reactome: R-HSA-1169091;Reactome: R-HSA-9615710;Reactome: R-HSA-2644606;Reactome: R-HSA-209543;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-209560;Reactome: R-HSA-195253;Reactome: R-HSA-977225;Reactome: R-HSA-174490;Reactome: R-HSA-1234176;Reactome: R-HSA-937042;Reactome: R-HSA-936440;Reactome: R-HSA-9010553;Reactome: R-HSA-975144;Reactome: R-HSA-3322077;Reactome: R-HSA-5678895;Reactome: R-HSA-901032;Reactome: R-HSA-201681;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-445989;Reactome: R-HSA-8856825;Reactome: R-HSA-936964;Reactome: R-HSA-2122947;Reactome: R-HSA-8849469;Reactome: R-HSA-8948747;Reactome: R-HSA-174178;Reactome: R-HSA-69481;Reactome: R-HSA-917729;Reactome: R-HSA-5676590;Reactome: R-HSA-156902;Reactome: R-HSA-5696400;Reactome: R-HSA-5610780;Reactome: R-HSA-6804756	"Negative regulation of MAPK pathway";"InlA-mediated entry of Listeria monocytogenes into host cells";"Translation initiation complex formation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Josephin domain DUBs";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Ub-specific processing proteases";"IRAK1 recruits IKK complex";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Formation of Incision Complex in GG-NER";"Circadian Clock";"Negative regulation of NOTCH4 signaling";"Oncogene Induced Senescence";"Translesion Synthesis by POLH";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of innate immune responses to cytosolic DNA";"Ovarian tumor domain proteases";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Stabilization of p53";"ER-Phagosome pathway";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Negative regulation of FGFR3 signaling";"Regulation of PLK1 Activity at G2/M Transition";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"GLI3 is processed to GLI3R by the proteasome";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Negative regulation of FGFR2 signaling";"Regulation of RAS by GAPs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Formation of TC-NER Pre-Incision Complex";"Translesion synthesis by POLI";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Dual incision in TC-NER";"EGFR downregulation";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Regulation of necroptotic cell death";"IKK complex recruitment mediated by RIP1";"Activated NOTCH1 Transmits Signal to the Nucleus";"Selenocysteine synthesis";"Modulation by Mtb of host immune system";"Stimuli-sensing channels";"TICAM1, RIP1-mediated IKK complex recruitment";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"Termination of translesion DNA synthesis";"CDT1 association with the CDC6:ORC:origin complex";"Chaperone Mediated Autophagy";"FCERI mediated NF-kB activation";"Negative regulation of MET activity";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Regulation of FZD by ubiquitination";"Assembly Of The HIV Virion";"Oxidative Stress Induced Senescence";"The role of GTSE1 in G2/M progression after G2 checkpoint";"NRIF signals cell death from the nucleus";"Processing of DNA double-strand break ends";"ISG15 antiviral mechanism";"Regulation of signaling by CBL";"Ribosomal scanning and start codon recognition";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Formation of the ternary complex, and subsequently, the 43S complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"NOD1/2 Signaling Pathway";"Hedgehog 'on' state";"Budding and maturation of HIV virion";"Prevention of phagosomal-lysosomal fusion";"DNA Damage Recognition in GG-NER";"Asymmetric localization of PCP proteins";"Downregulation of ERBB4 signaling";"TNFR1-induced NFkappaB signaling pathway";"Interleukin-1 signaling";"Alpha-protein kinase 1 signaling pathway";"Regulation of PTEN stability and activity";"Viral mRNA Translation";"Downregulation of ERBB2:ERBB3 signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Spry regulation of FGF signaling";"TICAM1-dependent activation of IRF3/IRF7";"Downregulation of ERBB2 signaling";"Downstream TCR signaling";"Myoclonic epilepsy of Lafora";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SCF-beta-TrCP mediated degradation of Emi1";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Deactivation of the beta-catenin transactivating complex";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"E3 ubiquitin ligases ubiquitinate target proteins";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Degradation of GLI2 by the proteasome";"Regulation of TNFR1 signaling";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"Fanconi Anemia Pathway";"Vif-mediated degradation of APOBEC3G";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Downregulation of TGF-beta receptor signaling";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"activated TAK1 mediates p38 MAPK activation";"InlB-mediated entry of Listeria monocytogenes into host cell";"Senescence-Associated Secretory Phenotype (SASP)";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Major pathway of rRNA processing in the nucleolus and cytosol";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"Gap-filling DNA repair synthesis and ligation in GG-NER";"APC/C:Cdc20 mediated degradation of Cyclin B";"Translesion synthesis by POLK";"CDK-mediated phosphorylation and removal of Cdc6";"HDR through Homologous Recombination (HRR)";"SRP-dependent cotranslational protein targeting to membrane";"Pink/Parkin Mediated Mitophagy";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Separation of Sister Chromatids";"Aggrephagy";"Neddylation";"Formation of a pool of free 40S subunits";"Negative regulation of FGFR1 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Vpu mediated degradation of CD4";"Cyclin D associated events in G1";"APC/C:Cdc20 mediated degradation of Securin";"Translesion synthesis by REV1";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"SCF(Skp2)-mediated degradation of p27/p21";"Negative regulation of FGFR4 signaling";"Metalloprotease DUBs";"ABC-family proteins mediated transport";"Clathrin-mediated endocytosis";"Iron uptake and transport";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulation of TP53 Activity through Methylation";"UCH proteinases";"Degradation of AXIN";"Regulation of TP53 Degradation";"Eukaryotic Translation Termination";"Recognition of DNA damage by PCNA-containing replication complex";"Peroxisomal protein import";"Activation of NF-kappaB in B cells";"Late endosomal microautophagy";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"p75NTR recruits signalling complexes";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"NF-kB is activated and signals survival";"Degradation of beta-catenin by the destruction complex";"Amyloid fiber formation";"Membrane binding and targetting of GAG proteins";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"IRAK2 mediated activation of TAK1 complex";"Negative regulators of DDX58/IFIH1 signaling";"Regulation of expression of SLITs and ROBOs";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Glycogen synthesis";"Defective CFTR causes cystic fibrosis";"ER Quality Control Compartment (ERQC)";"TCF dependent signaling in response to WNT";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Cargo recognition for clathrin-mediated endocytosis";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"NOTCH1 Intracellular Domain Regulates Transcription";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"Regulation of PTEN localization";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"G2/M Checkpoints";"Endosomal Sorting Complex Required For Transport (ESCRT)";"NIK-->noncanonical NF-kB signaling";"Peptide chain elongation";"Dual Incision in GG-NER";"Degradation of GLI1 by the proteasome";"Regulation of TP53 Activity through Phosphorylation"
APLA002308-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA002046-PA	2	Reactome: R-HSA-6793080;Reactome: R-HSA-2151201	"rRNA modification in the mitochondrion";"Transcriptional activation of mitochondrial biogenesis"
APLA004447-PA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA009473-PA	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
APLA000551-PA	3	Reactome: R-HSA-5689877;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394	"Josephin domain DUBs";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER"
APLA012675-PA	6	Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604	"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA"
APLA002854-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA011024-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA008234-PA	1	Reactome: R-HSA-427359	"SIRT1 negatively regulates rRNA expression"
APLA014516-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA011356-PA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
APLA009050-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA007888-PA	1	Reactome: R-HSA-212300	"PRC2 methylates histones and DNA"
APLA000849-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA005502-PA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
APLA001755-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA008650-PA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
APLA013714-PA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
APLA002052-PA	4	KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193;Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48	"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I";"Pyrimidine salvage";"Drug metabolism - other enzymes"
APLA000270-PA	3	Reactome: R-HSA-983168;Reactome: R-HSA-3065678;Reactome: R-HSA-3065676	"Antigen processing: Ubiquitination & Proteasome degradation";"SUMO is transferred from E1 to E2 (UBE2I, UBC9)";"SUMO is conjugated to E1 (UBA2:SAE1)"
APLA003259-PA	9	Reactome: R-HSA-442982;Reactome: R-HSA-9609736;Reactome: R-HSA-438066;Reactome: R-HSA-9620244;Reactome: R-HSA-9617324;Reactome: R-HSA-6794361;Reactome: R-HSA-3928662;Reactome: R-HSA-8849932;Reactome: R-HSA-5673001	"Ras activation upon Ca2+ influx through NMDA receptor";"Assembly and cell surface presentation of NMDA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"Long-term potentiation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Neurexins and neuroligins";"EPHB-mediated forward signaling";"Synaptic adhesion-like molecules";"RAF/MAP kinase cascade"
APLA009371-PA	4	Reactome: R-HSA-3214847;Reactome: R-HSA-5689603;KEGG: 00514+2.4.1.255;MetaCyc: PWY-7437	"HATs acetylate histones";"UCH proteinases";"Other types of O-glycan biosynthesis";"Protein O-[N-acetyl]-glucosylation"
APLA003024-PA	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
APLA009489-PA	6	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-9010553;Reactome: R-HSA-975957	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA001351-PA	6	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase"
APLA012442-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA004098-PA	3	Reactome: R-HSA-416476;Reactome: R-HSA-375276;Reactome: R-HSA-418594	"G alpha (q) signalling events";"Peptide ligand-binding receptors";"G alpha (i) signalling events"
APLA011527-PA	2	Reactome: R-HSA-975957;Reactome: R-HSA-975956	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
APLA007948-PA	3	Reactome: R-HSA-196783;MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33	"Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis"
APLA005297-PA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
APLA010971-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA012207-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA008741-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA004454-PA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
APLA008272-PA	6	MetaCyc: PWY-6118;MetaCyc: PWY-6952;KEGG: 00564+1.1.5.3;MetaCyc: PWY-4261;Reactome: R-HSA-163560;Reactome: R-HSA-1483166	"Glycerol-3-phosphate shuttle";"Glycerophosphodiester degradation";"Glycerophospholipid metabolism";"Glycerol degradation I";"Triglyceride catabolism";"Synthesis of PA"
APLA005703-PA	12	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase III Abortive And Retractive Initiation"
APLA012836-PA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
APLA003720-PA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
APLA006643-PA	15	Reactome: R-HSA-5693554;Reactome: R-HSA-5693565;Reactome: R-HSA-5685938;Reactome: R-HSA-5685939;Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-2559586;Reactome: R-HSA-5693548;Reactome: R-HSA-6804756;Reactome: R-HSA-5693571;Reactome: R-HSA-69473;Reactome: R-HSA-5693607	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDR through Single Strand Annealing (SSA)";"HDR through MMEJ (alt-NHEJ)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"DNA Damage/Telomere Stress Induced Senescence";"Sensing of DNA Double Strand Breaks";"Regulation of TP53 Activity through Phosphorylation";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends"
APLA008029-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA012404-PA	3	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
APLA001229-PA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
APLA004346-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA014336-PA	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
APLA014477-PA	3	MetaCyc: PWY-6596;Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6	"Adenosine nucleotides degradation I";"Purine salvage";"Purine metabolism"
APLA007635-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA000850-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA003033-PA	1	Reactome: R-HSA-112308	"Presynaptic depolarization and calcium channel opening"
APLA011047-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA010993-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA008337-PA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA004875-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA011482-PA	9	Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-6804756;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-167161	"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Regulation of TP53 Activity through Phosphorylation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation"
APLA003893-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA007500-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA007139-PA	4	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
APLA005953-PA	14	Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-205043;Reactome: R-HSA-2979096;Reactome: R-HSA-193692;Reactome: R-HSA-3928665;Reactome: R-HSA-977225;Reactome: R-HSA-1251985;Reactome: R-HSA-6798695;Reactome: R-HSA-2644606;Reactome: R-HSA-9013700;Reactome: R-HSA-9017802;Reactome: R-HSA-1474228;Reactome: R-HSA-2894862	"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NRIF signals cell death from the nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Regulated proteolysis of p75NTR";"EPH-ephrin mediated repulsion of cells";"Amyloid fiber formation";"Nuclear signaling by ERBB4";"Neutrophil degranulation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Degradation of the extracellular matrix";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
APLA014098-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA011409-PA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
APLA000545-PA	6	MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis"
APLA001742-PA	1	Reactome: R-HSA-1296061	"HCN channels"
APLA013473-PA	4	Reactome: R-HSA-1268020;Reactome: R-HSA-8949613;Reactome: R-HSA-8950505;Reactome: R-HSA-3371453	"Mitochondrial protein import";"Cristae formation";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Regulation of HSF1-mediated heat shock response"
APLA002019-PA	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
APLA003782-PA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
APLA000862-PA	14	MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-5972	"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)"
APLA012569-PA	2	Reactome: R-HSA-204174;Reactome: R-HSA-5362517	"Regulation of pyruvate dehydrogenase (PDH) complex";"Signaling by Retinoic Acid"
APLA005818-PA	1	KEGG: 00565+3.1.1.47	"Ether lipid metabolism"
APLA007882-PA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
APLA008915-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA000158-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
APLA012066-PA	3	KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3;MetaCyc: PWY-6317	"Galactose metabolism";"Glycolysis / Gluconeogenesis";"D-galactose degradation I (Leloir pathway)"
APLA003315-PA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
APLA009992-PA	4	Reactome: R-HSA-186763;Reactome: R-HSA-912631;Reactome: R-HSA-8875555;Reactome: R-HSA-8875656	"Downstream signal transduction";"Regulation of signaling by CBL";"MET activates RAP1 and RAC1";"MET receptor recycling"
APLA003179-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA012070-PA	8	KEGG: 04926+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Major pathway of rRNA processing in the nucleolus and cytosol";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
APLA001067-PA	2	Reactome: R-HSA-1799339;Reactome: R-HSA-446203	"SRP-dependent cotranslational protein targeting to membrane";"Asparagine N-linked glycosylation"
APLA011952-PA	4	Reactome: R-HSA-9615710;Reactome: R-HSA-3899300;Reactome: R-HSA-9646399;Reactome: R-HSA-9613829	"Late endosomal microautophagy";"SUMOylation of transcription cofactors";"Aggrephagy";"Chaperone Mediated Autophagy"
APLA002277-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA003839-PA	6	KEGG: 04660+3.1.3.16;Reactome: R-HSA-400253;KEGG: 04658+3.1.3.16;Reactome: R-HSA-2173788;Reactome: R-HSA-163560;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Circadian Clock";"Th1 and Th2 cell differentiation";"Downregulation of TGF-beta receptor signaling";"Triglyceride catabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA003313-PA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
APLA000209-PA	6	Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513	"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
APLA006614-PA	7	KEGG: 00360+1.14.16.1;KEGG: 00400+1.14.16.1;KEGG: 00790+1.14.16.1;MetaCyc: PWY-7158;MetaCyc: PWY-6134;Reactome: R-HSA-2160456;Reactome: R-HSA-8964208	"Phenylalanine metabolism";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Folate biosynthesis";"L-phenylalanine degradation V";"L-tyrosine biosynthesis IV";"Phenylketonuria";"Phenylalanine metabolism"
APLA006458-PA	4	Reactome: R-HSA-446193;KEGG: 00510+2.4.1.131;Reactome: R-HSA-4551295;KEGG: 00513+2.4.1.131	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Defective ALG11 causes ALG11-CDG (CDG-1p)";"Various types of N-glycan biosynthesis"
APLA014343-PA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649	"Selenocysteine synthesis";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation"
APLA012607-PA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
APLA008829-PA	3	Reactome: R-HSA-5083629;Reactome: R-HSA-5083633;Reactome: R-HSA-5173105	"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"O-linked glycosylation"
APLA012477-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA012149-PA	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA002213-PA	7	MetaCyc: PWY-6470;MetaCyc: PWY-5265;Reactome: R-HSA-446193;MetaCyc: PWY-6471;KEGG: 00510+2.7.8.15;Reactome: R-HSA-4549356;KEGG: 00550+2.7.8.13	"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis II (staphylococci)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"N-Glycan biosynthesis";"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2";"Peptidoglycan biosynthesis"
APLA000150-PA	2	KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20	"Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism"
APLA004609-PA	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
APLA009154-PA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
APLA014002-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-171319	"rRNA modification in the nucleus and cytosol";"Telomere Extension By Telomerase"
APLA001687-PA	2	Reactome: R-HSA-382556;Reactome: R-HSA-5678895	"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis"
APLA006729-PA	1	Reactome: R-HSA-74217	"Purine salvage"
APLA010841-PA	3	KEGG: 00230+1.7.3.3;KEGG: 00232+1.7.3.3;MetaCyc: PWY-5691	"Purine metabolism";"Caffeine metabolism";"Urate conversion to allantoin I"
APLA014655-PA	8	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04660+2.7.10.2;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"T cell receptor signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Relaxin signaling pathway"
APLA001197-PA	3	Reactome: R-HSA-6784531;Reactome: R-HSA-6785470;Reactome: R-HSA-8868766	"tRNA processing in the nucleus";"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion"
APLA003964-PA	2	Reactome: R-HSA-5694530;Reactome: R-HSA-204005	"Cargo concentration in the ER";"COPII-mediated vesicle transport"
APLA014536-PA	4	Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"COPI-mediated anterograde transport"
APLA007673-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA007873-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA010777-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA012153-PA	2	Reactome: R-HSA-4086398;Reactome: R-HSA-418457	"Ca2+ pathway";"cGMP effects"
APLA009182-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA001435-PA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
APLA015233-PA	6	Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-73856;Reactome: R-HSA-111367;Reactome: R-HSA-191859;Reactome: R-HSA-77588	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Termination";"SLBP independent Processing of Histone Pre-mRNAs";"snRNP Assembly";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"
APLA004217-PA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
APLA015343-PA	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway"
APLA003316-PA	2	Reactome: R-HSA-5689896;Reactome: R-HSA-195253	"Ovarian tumor domain proteases";"Degradation of beta-catenin by the destruction complex"
APLA007956-PA	17	Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-6790901;Reactome: R-HSA-72706;Reactome: R-HSA-72649	"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"rRNA modification in the nucleus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation"
APLA004522-PA	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
APLA003107-PA	3	Reactome: R-HSA-1483191;Reactome: R-HSA-422085;Reactome: R-HSA-112311	"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin";"Neurotransmitter clearance"
APLA003043-PA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
APLA011027-PA	4	Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-375165;Reactome: R-HSA-5673001	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade"
APLA007492-PA	13	Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-72689	"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits"
APLA007456-PA	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
APLA010068-PA	14	MetaCyc: PWY-7619;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-5972;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7601;Reactome: R-HSA-75876	"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs"
APLA000863-PA	14	MetaCyc: PWY-7725;MetaCyc: PWY-8041;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-5972;MetaCyc: PWY-7619;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6433	"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)"
APLA009089-PA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
APLA003759-PA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
APLA012876-PA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
APLA004449-PA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
APLA007975-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA011782-PA	1	Reactome: R-HSA-1483191	"Synthesis of PC"
APLA012068-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA004175-PA	6	KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241;Reactome: R-HSA-3299685;Reactome: R-HSA-6798695;Reactome: R-HSA-9615017;KEGG: 00380+1.11.1.6	"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import";"Detoxification of Reactive Oxygen Species";"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Tryptophan metabolism"
APLA014245-PA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
APLA011579-PA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
APLA003440-PA	4	MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-7822	"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)"
APLA011349-PA	5	KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2	"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation";"Lysine degradation"
APLA003647-PA	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
APLA014433-PA	8	Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-68689;Reactome: R-HSA-176187;Reactome: R-HSA-68616	"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication"
APLA013187-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA009060-PA	1	Reactome: R-HSA-8876725	"Protein methylation"
APLA001592-PA	4	Reactome: R-HSA-379716;Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.10;KEGG: 00450+6.1.1.10	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis";"Selenocompound metabolism"
APLA010196-PA	24	Reactome: R-HSA-8955332;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-5617833;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-983189;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025	"Carboxyterminal post-translational modifications of tubulin";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Separation of Sister Chromatids";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"Cilium Assembly";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"Gap junction assembly";"HCMV Early Events";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Kinesins";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation"
APLA012643-PA	2	KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7	"Pyruvate metabolism";"Aminobenzoate degradation"
APLA009180-PA	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
APLA007977-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA006570-PA	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
APLA013400-PA	11	Reactome: R-HSA-163615;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-164378;Reactome: R-HSA-170670;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-418597;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-5610787	"PKA activation";"G alpha (i) signalling events";"Purine metabolism";"PKA activation in glucagon signalling";"Adenylate cyclase inhibitory pathway";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"Hedgehog 'off' state"
APLA005056-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA005819-PA	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
APLA014307-PA	7	Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-6811434;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"COPI-dependent Golgi-to-ER retrograde traffic";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation"
APLA005083-PA	2	Reactome: R-HSA-71336;KEGG: 00030+2.7.1.15	"Pentose phosphate pathway";"Pentose phosphate pathway"
APLA003634-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA013801-PA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
APLA010384-PA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
APLA012011-PA	4	Reactome: R-HSA-77595;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
APLA008790-PA	13	Reactome: R-HSA-6798695;Reactome: R-HSA-3371511;Reactome: R-HSA-5362768;Reactome: R-HSA-5689896;Reactome: R-HSA-382556;Reactome: R-HSA-532668;Reactome: R-HSA-8866654;Reactome: R-HSA-5689877;Reactome: R-HSA-110320;Reactome: R-HSA-5358346;Reactome: R-HSA-9646399;Reactome: R-HSA-5678895;Reactome: R-HSA-8876725	"Neutrophil degranulation";"HSF1 activation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ovarian tumor domain proteases";"ABC-family proteins mediated transport";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"E3 ubiquitin ligases ubiquitinate target proteins";"Josephin domain DUBs";"Translesion Synthesis by POLH";"Hedgehog ligand biogenesis";"Aggrephagy";"Defective CFTR causes cystic fibrosis";"Protein methylation"
APLA011713-PA	56	Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-1236978;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-450408;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5678895;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-187577;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-4641257;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902	"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Cross-presentation of soluble exogenous antigens (endosomes)";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Neddylation";"Separation of Sister Chromatids";"Defective CFTR causes cystic fibrosis";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"SCF(Skp2)-mediated degradation of p27/p21";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of AXIN";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Regulation of RUNX2 expression and activity"
APLA001683-PA	7	Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
APLA012384-PA	12	KEGG: 00565+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-7417;MetaCyc: PWY-7416;MetaCyc: PWY-7783	"Ether lipid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Arachidonic acid metabolism";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Plasmalogen degradation"
APLA008767-PA	5	Reactome: R-HSA-196025;Reactome: R-HSA-3928665;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-190873	"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Gap junction degradation"
APLA008114-PA	22	Reactome: R-HSA-75876;MetaCyc: PWY-7727;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7606;MetaCyc: PWY-5080;MetaCyc: PWY-6958;MetaCyc: PWY-7049;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7592;MetaCyc: PWY-7724;MetaCyc: PWY-7035;MetaCyc: PWY-7728;MetaCyc: PWY-5353;MetaCyc: PWY-7726;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7053	"Synthesis of very long-chain fatty acyl-CoAs";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Fatty acid elongation";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Docosahexaenoate biosynthesis I (lower eukaryotes)"
APLA010128-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA000669-PA	1	Reactome: R-HSA-5250924	"B-WICH complex positively regulates rRNA expression"
APLA015304-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA014672-PA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
APLA001704-PA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
APLA000938-PA	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
APLA014395-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA010682-PA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
APLA006584-PA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
APLA009590-PA	6	Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-5693616;Reactome: R-HSA-912446	"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination"
APLA011351-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA011135-PA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
APLA002200-PA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
APLA008179-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA008961-PA	7	Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-390471;Reactome: R-HSA-389957;Reactome: R-HSA-5620922;Reactome: R-HSA-6798695	"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Association of TriC/CCT with target proteins during biosynthesis";"Prefoldin mediated transfer of substrate to CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Neutrophil degranulation"
APLA013379-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA002934-PA	10	Reactome: R-HSA-5684264;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-5607764;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-2565942	"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Neddylation";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"CLEC7A (Dectin-1) signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Regulation of PLK1 Activity at G2/M Transition"
APLA012905-PA	3	KEGG: 00030+1.1.1.44;Reactome: R-HSA-71336;KEGG: 00480+1.1.1.44	"Pentose phosphate pathway";"Pentose phosphate pathway";"Glutathione metabolism"
APLA003655-PA	6	Reactome: R-HSA-3878781;MetaCyc: PWY-7900;Reactome: R-HSA-3322077;MetaCyc: PWY-622;KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067	"Glycogen storage disease type IV (GBE1)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen synthesis";"Starch biosynthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)"
APLA007255-PA	8	Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7979;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109	"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis"
APLA001611-PA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
APLA012226-PA	13	Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-975956	"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
APLA010406-PA	2	Reactome: R-HSA-6803157;Reactome: R-HSA-6798695	"Antimicrobial peptides";"Neutrophil degranulation"
APLA015202-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA014022-PA	3	MetaCyc: PWY-7892;MetaCyc: PWY-7887;Reactome: R-HSA-6787450	"Trna-uridine 2-thiolation and selenation (bacteria)";"Protein SAMPylation and SAMP-mediated thiolation";"tRNA modification in the mitochondrion"
APLA009540-PA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
APLA010040-PA	16	Reactome: R-HSA-72695;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553	"Formation of the ternary complex, and subsequently, the 43S complex";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs"
APLA004353-PA	2	Reactome: R-HSA-201722;Reactome: R-HSA-171319	"Formation of the beta-catenin:TCF transactivating complex";"Telomere Extension By Telomerase"
APLA005325-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA002687-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA005145-PA	9	Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-6804756;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-674695	"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events"
APLA008510-PA	3	Reactome: R-HSA-1799339;Reactome: R-HSA-9609523;Reactome: R-HSA-1236974	"SRP-dependent cotranslational protein targeting to membrane";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"ER-Phagosome pathway"
APLA015180-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA000483-PA	1	Reactome: R-HSA-6806664	"Metabolism of vitamin K"
APLA012587-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA009499-PA	4	Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex"
APLA002318-PA	2	Reactome: R-HSA-1566948;Reactome: R-HSA-2243919	"Elastic fibre formation";"Crosslinking of collagen fibrils"
APLA014681-PA	2	Reactome: R-HSA-983231;Reactome: R-HSA-5205685	"Factors involved in megakaryocyte development and platelet production";"Pink/Parkin Mediated Mitophagy"
APLA010460-PA	57	Reactome: R-HSA-5678895;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-1236974;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-187577;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-6798695	"Defective CFTR causes cystic fibrosis";"Separation of Sister Chromatids";"Neddylation";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"ER-Phagosome pathway";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Degradation of AXIN";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"SCF(Skp2)-mediated degradation of p27/p21";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"Neutrophil degranulation"
APLA001106-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA005932-PA	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
APLA011359-PA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
APLA009701-PA	2	Reactome: R-HSA-877312;Reactome: R-HSA-6807004	"Regulation of IFNG signaling";"Negative regulation of MET activity"
APLA003943-PA	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
APLA013236-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA015240-PA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
APLA009372-PA	18	MetaCyc: PWY-7226;MetaCyc: PWY-7224;MetaCyc: PWY-7197;MetaCyc: PWY-7187;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7210;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7220;MetaCyc: PWY-7184;MetaCyc: PWY-6545;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7176;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7222;Reactome: R-HSA-499943;MetaCyc: PWY-7205;MetaCyc: PWY-7221	"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"UTP and CTP de novo biosynthesis";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Interconversion of nucleotide di- and triphosphates";"CMP phosphorylation";"Guanosine ribonucleotides de novo biosynthesis"
APLA000090-PA	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
APLA000806-PA	16	Reactome: R-HSA-141430;Reactome: R-HSA-174184;Reactome: R-HSA-2559582;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-176407;Reactome: R-HSA-2467813;Reactome: R-HSA-176408;Reactome: R-HSA-69017;Reactome: R-HSA-983168;Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-174048	"Inactivation of APC/C via direct inhibition of the APC/C complex";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Senescence-Associated Secretory Phenotype (SASP)";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Separation of Sister Chromatids";"Regulation of APC/C activators between G1/S and early anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"Antigen processing: Ubiquitination & Proteasome degradation";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"APC/C:Cdc20 mediated degradation of Cyclin B"
APLA014759-PA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
APLA001137-PA	11	MetaCyc: PWY-6549;MetaCyc: PWY-7268;KEGG: 00720+1.1.1.42;MetaCyc: PWY-5913;KEGG: 00020+1.1.1.42;MetaCyc: PWY-7254;MetaCyc: PWY-6969;MetaCyc: PWY-7124;MetaCyc: PWY-6728;Reactome: R-HSA-71403;KEGG: 00480+1.1.1.42	"L-glutamine biosynthesis III";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Carbon fixation pathways in prokaryotes";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Ethylene biosynthesis V (engineered)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Glutathione metabolism"
APLA014848-PA	5	MetaCyc: PWY-6527;MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6317;KEGG: 00520+2.7.1.6	"Stachyose degradation";"D-galactose detoxification";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism"
APLA015237-PA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
APLA004211-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA007201-PA	12	KEGG: 00280+6.4.1.3;MetaCyc: PWY-5743;MetaCyc: PWY-6728;Reactome: R-HSA-3371599;KEGG: 00640+6.4.1.3;MetaCyc: PWY-5789;MetaCyc: PWY-7384;Reactome: R-HSA-196780;Reactome: R-HSA-71032;KEGG: 00720+6.4.1.3;KEGG: 00630+6.4.1.3;MetaCyc: PWYG-321	"Valine, leucine and isoleucine degradation";"3-hydroxypropanoate cycle";"Methylaspartate cycle";"Defective HLCS causes multiple carboxylase deficiency";"Propanoate metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Biotin transport and metabolism";"Propionyl-CoA catabolism";"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism";""
APLA006695-PA	5	Reactome: R-HSA-69205;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-68827	"G1/S-Specific Transcription";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex"
APLA005825-PA	3	Reactome: R-HSA-6787450;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470	"tRNA modification in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion"
APLA009143-PA	8	KEGG: 00520+4.2.1.47;Reactome: R-HSA-6787639;MetaCyc: PWY-5740;MetaCyc: PWY-5738;MetaCyc: PWY-5739;MetaCyc: PWY-7573;MetaCyc: PWY-66;KEGG: 00051+4.2.1.47	"Amino sugar and nucleotide sugar metabolism";"GDP-fucose biosynthesis";"GDP-L-colitose biosynthesis";"GDP-6-deoxy-D-talose biosynthesis";"GDP-D-perosamine biosynthesis";"GDP-mycosamine biosynthesis";"GDP-L-fucose biosynthesis I (from GDP-D-mannose)";"Fructose and mannose metabolism"
APLA006698-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA002539-PA	4	KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.32	"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism"
APLA001010-PA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
APLA004281-PA	1	KEGG: 00970+6.1.1.1	"Aminoacyl-tRNA biosynthesis"
APLA009753-PA	16	Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72695	"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex"
APLA012185-PA	16	Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689	"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits"
APLA000131-PA	4	Reactome: R-HSA-379716;Reactome: R-HSA-2408522;Reactome: R-HSA-379726;KEGG: 00970+6.1.1.18	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
APLA006748-PA	5	Reactome: R-HSA-110329;Reactome: R-HSA-5221030;Reactome: R-HSA-110357;Reactome: R-HSA-3108214;Reactome: R-HSA-110328	"Cleavage of the damaged pyrimidine";"TET1,2,3 and TDG demethylate DNA";"Displacement of DNA glycosylase by APEX1";"SUMOylation of DNA damage response and repair proteins";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
APLA000613-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA004358-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA013772-PA	4	Reactome: R-HSA-6814122;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-112043	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events";"G-protein activation";"PLC beta mediated events"
APLA009999-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
APLA001399-PA	1	Reactome: R-HSA-5689901	"Metalloprotease DUBs"
APLA003009-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA009136-PA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
APLA005715-PA	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
APLA011623-PA	5	Reactome: R-HSA-5610787;Reactome: R-HSA-5610780;Reactome: R-HSA-5610785;Reactome: R-HSA-5632684;Reactome: R-HSA-5610783	"Hedgehog 'off' state";"Degradation of GLI1 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog 'on' state";"Degradation of GLI2 by the proteasome"
APLA011220-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA009661-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA001404-PA	5	Reactome: R-HSA-450604;Reactome: R-HSA-430039;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-450513	"KSRP (KHSRP) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
APLA008611-PA	6	Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-69052	"Assembly of the pre-replicative complex";"Unwinding of DNA";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state"
APLA014048-PA	24	Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-983189;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-3371497;Reactome: R-HSA-9609736;Reactome: R-HSA-9619483;Reactome: R-HSA-68877;Reactome: R-HSA-5617833;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-8955332	"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Kinesins";"HCMV Early Events";"Gap junction assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Assembly and cell surface presentation of NMDA receptors";"Activation of AMPK downstream of NMDARs";"Mitotic Prometaphase";"Cilium Assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Separation of Sister Chromatids";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Carboxyterminal post-translational modifications of tubulin"
APLA013455-PA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
APLA010595-PA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
APLA007891-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA006636-PA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-611105	"Mitochondrial protein import";"Respiratory electron transport"
APLA006060-PA	27	Reactome: R-HSA-5619107;Reactome: R-HSA-170822;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-3371453;Reactome: R-HSA-168333;Reactome: R-HSA-5578749;Reactome: R-HSA-3232142;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-3301854;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-4085377;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-9610379	"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Regulation of HSF1-mediated heat shock response";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transcriptional regulation by small RNAs";"SUMOylation of ubiquitinylation proteins";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"SUMOylation of SUMOylation proteins";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"HCMV Late Events"
APLA012141-PA	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
APLA003221-PA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
APLA014593-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6798695	"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation"
APLA003252-PA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
APLA004294-PA	10	MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-5826;MetaCyc: PWY-7559;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-4061;MetaCyc: PWY-7112;MetaCyc: PWY-6842;KEGG: 00460+2.3.2.2	"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Gamma-glutamyl cycle";"Hypoglycin biosynthesis";"Glutathione degradation (DUG pathway";"Glutathione metabolism";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification II";"Cyanoamino acid metabolism"
APLA000469-PA	1	Reactome: R-HSA-912446	"Meiotic recombination"
APLA012713-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA004772-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA012854-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
APLA002044-PA	13	MetaCyc: PWY-6902;Reactome: R-HSA-2022857;MetaCyc: PWY-7822;Reactome: R-HSA-1660662;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7883;KEGG: 00603+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2160916	"Chitin degradation II (Vibrio)";"Keratan sulfate degradation";"Chitin degradation III (Serratia)";"Glycosphingolipid metabolism";"Various types of N-glycan biosynthesis";"CS/DS degradation";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Hyaluronan uptake and degradation"
APLA009973-PA	4	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA006991-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA000368-PA	8	Reactome: R-HSA-77387;Reactome: R-HSA-167590;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-9636467;Reactome: R-HSA-9639288;Reactome: R-HSA-182218;Reactome: R-HSA-917977	"Insulin receptor recycling";"Nef Mediated CD4 Down-regulation";"Ion channel transport";"ROS and RNS production in phagocytes";"Blockage of phagosome acidification";"Amino acids regulate mTORC1";"Nef Mediated CD8 Down-regulation";"Transferrin endocytosis and recycling"
APLA015335-PA	4	KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;Reactome: R-HSA-499943	"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Interconversion of nucleotide di- and triphosphates"
APLA005955-PA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
APLA005342-PA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
APLA003426-PA	2	Reactome: R-HSA-2514853;Reactome: R-HSA-2299718	"Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes"
APLA000619-PA	12	KEGG: 00051+4.1.2.13;MetaCyc: PWY-1042;MetaCyc: PWY-6142;Reactome: R-HSA-70263;MetaCyc: PWY-5484;KEGG: 00030+4.1.2.13;MetaCyc: PWY-1861;KEGG: 00680+4.1.2.13;Reactome: R-HSA-70171;MetaCyc: PWY-7385;KEGG: 00710+4.1.2.13;KEGG: 00010+4.1.2.13	"Fructose and mannose metabolism";"Glycolysis IV (plant cytosol)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Methane metabolism";"Glycolysis";"1,3-propanediol biosynthesis (engineered)";"Carbon fixation in photosynthetic organisms";"Glycolysis / Gluconeogenesis"
APLA010491-PA	2	Reactome: R-HSA-5205685;Reactome: R-HSA-1268020	"Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import"
APLA005079-PA	1	Reactome: R-HSA-71336	"Pentose phosphate pathway"
APLA002059-PA	3	Reactome: R-HSA-5423646;Reactome: R-HSA-2142691;MetaCyc: PWY-7533	"Aflatoxin activation and detoxification";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis"
APLA008112-PA	32	Reactome: R-HSA-167160;Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-8851708;Reactome: R-HSA-72163;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-167246;Reactome: R-HSA-72203;Reactome: R-HSA-167161;Reactome: R-HSA-168325;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-6803529;Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648;Reactome: R-HSA-72165;Reactome: R-HSA-167242;Reactome: R-HSA-167238;Reactome: R-HSA-9018519	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"Signaling by FGFR2 IIIa TM";"mRNA Splicing - Major Pathway";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Tat-mediated elongation of the HIV-1 transcript";"Processing of Capped Intron-Containing Pre-mRNA";"HIV Transcription Initiation";"Viral Messenger RNA Synthesis";"mRNA Capping";"Formation of the Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"FGFR2 alternative splicing";"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Splicing - Minor Pathway";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Estrogen-dependent gene expression"
APLA001658-PA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
APLA005454-PA	18	Reactome: R-HSA-6790901;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-166208;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-2408557	"rRNA modification in the nucleus and cytosol";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"mTORC1-mediated signalling";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Selenocysteine synthesis"
APLA007872-PA	16	Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-141430;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-2559582;Reactome: R-HSA-174184;Reactome: R-HSA-983168;Reactome: R-HSA-174048;Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-176407;Reactome: R-HSA-2467813;Reactome: R-HSA-69017;Reactome: R-HSA-176408	"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Cyclin B";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Separation of Sister Chromatids";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of APC/C activators between G1/S and early anaphase"
APLA013062-PA	1	Reactome: R-HSA-186797	"Signaling by PDGF"
APLA009501-PA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
APLA005476-PA	6	Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156827	"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression"
APLA000554-PA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
APLA006201-PA	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
APLA014258-PA	6	Reactome: R-HSA-6803211;Reactome: R-HSA-6803204;Reactome: R-HSA-139915;Reactome: R-HSA-6803205;Reactome: R-HSA-6804759;Reactome: R-HSA-6803207	"TP53 Regulates Transcription of Death Receptors and Ligands";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Activation of PUMA and translocation to mitochondria";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"Regulation of TP53 Activity through Association with Co-factors";"TP53 Regulates Transcription of Caspase Activators and Caspases"
APLA009159-PA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
APLA001648-PA	2	Reactome: R-HSA-8866907;Reactome: R-HSA-8866904	"Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors"
APLA009072-PA	5	MetaCyc: PWY-4361;KEGG: 00270+4.2.1.109;Reactome: R-HSA-1237112;Reactome: R-HSA-9627069;Reactome: R-HSA-111458	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism";"Methionine salvage pathway";"Regulation of the apoptosome activity";"Formation of apoptosome"
APLA014380-PA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
APLA001953-PA	26	Reactome: R-HSA-3371497;Reactome: R-HSA-9609736;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-389960;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-5617833;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-983189;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-6811434;Reactome: R-HSA-8955332;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-389977	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Assembly and cell surface presentation of NMDA receptors";"HCMV Early Events";"Gap junction assembly";"Formation of tubulin folding intermediates by CCT/TriC";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Cilium Assembly";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Kinesins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"COPI-dependent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"Post-chaperonin tubulin folding pathway"
APLA002142-PA	3	MetaCyc: PWY-7277;Reactome: R-HSA-1660662;KEGG: 00600+3.1.4.12	"Sphingolipid biosynthesis (mammals)";"Glycosphingolipid metabolism";"Sphingolipid metabolism"
APLA009733-PA	3	Reactome: R-HSA-6782315;MetaCyc: PWY-6700;MetaCyc: PWY-8106	"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis I (de novo)";"Queuosine biosynthesis III (queuosine salvage)"
APLA007912-PA	3	Reactome: R-HSA-6807505;Reactome: R-HSA-749476;Reactome: R-HSA-76071	"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter"
APLA000737-PA	8	Reactome: R-HSA-70268;MetaCyc: PWY-5481;KEGG: 00010+1.1.1.27;KEGG: 00620+1.1.1.27;MetaCyc: PWY-6901;MetaCyc: PWY-8086;KEGG: 00270+1.1.1.27;KEGG: 00640+1.1.1.27	"Pyruvate metabolism";"Pyruvate fermentation to (S)-lactate";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Cysteine and methionine metabolism";"Propanoate metabolism"
APLA013884-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA000512-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA000132-PA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
APLA005738-PA	4	KEGG: 00230+6.3.5.2;Reactome: R-HSA-73817;MetaCyc: PWY-7221;KEGG: 00983+6.3.5.2	"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes"
APLA008934-PA	2	Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2	"Signaling by SCF-KIT";"T cell receptor signaling pathway"
APLA006251-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA004856-PA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
APLA001650-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA003311-PA	6	Reactome: R-HSA-427359;Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-73772	"SIRT1 negatively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape"
APLA010331-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA014278-PA	11	Reactome: R-HSA-163615;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-164378;Reactome: R-HSA-170670;Reactome: R-HSA-432040;Reactome: R-HSA-418597;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-5610787	"PKA activation";"G alpha (i) signalling events";"Purine metabolism";"Adenylate cyclase activating pathway";"PKA activation in glucagon signalling";"Adenylate cyclase inhibitory pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"Hedgehog 'off' state"
APLA003657-PA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
APLA001210-PA	4	MetaCyc: PWY-6834;KEGG: 00270+4.1.1.50;KEGG: 00330+4.1.1.50;Reactome: R-HSA-351202	"Spermidine biosynthesis III";"Cysteine and methionine metabolism";"Arginine and proline metabolism";"Metabolism of polyamines"
APLA009770-PA	2	KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600	"Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
APLA008649-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA001129-PA	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
APLA012900-PA	3	KEGG: 00480+1.1.1.44;KEGG: 00030+1.1.1.44;Reactome: R-HSA-71336	"Glutathione metabolism";"Pentose phosphate pathway";"Pentose phosphate pathway"
APLA015072-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA001000-PA	5	Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-983170;Reactome: R-HSA-204005;Reactome: R-HSA-2132295	"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"COPII-mediated vesicle transport";"MHC class II antigen presentation"
APLA009816-PA	10	MetaCyc: PWY-8051;MetaCyc: PWY-7587;KEGG: 00564+2.3.1.15;MetaCyc: PWY-8053;Reactome: R-HSA-1483166;MetaCyc: PWY-6453;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.15;MetaCyc: PWY-7411;MetaCyc: PWY-5667	"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism";"Anandamide biosynthesis II";"Synthesis of PA";"Stigma estolide biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis I"
APLA000135-PA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
APLA002948-PA	5	Reactome: R-HSA-5579026;Reactome: R-HSA-211976;Reactome: R-HSA-2395516;Reactome: R-HSA-196108;Reactome: R-HSA-1362409	"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Endogenous sterols";"Electron transport from NADPH to Ferredoxin";"Pregnenolone biosynthesis";"Mitochondrial iron-sulfur cluster biogenesis"
APLA001946-PA	1	Reactome: R-HSA-72731	"Recycling of eIF2:GDP"
APLA003180-PA	10	Reactome: R-HSA-1855204;MetaCyc: PWY-6554;Reactome: R-HSA-1855167;MetaCyc: PWY-6362;MetaCyc: PWY-4661;KEGG: 04070+2.7.1.159;Reactome: R-HSA-983231;KEGG: 00562+2.7.1.134+2.7.1.159;MetaCyc: PWY-6366;MetaCyc: PWY-6365	"Synthesis of IP3 and IP4 in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Phosphatidylinositol signaling system";"Factors involved in megakaryocyte development and platelet production";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis";"D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis"
APLA001208-PA	5	Reactome: R-HSA-110357;Reactome: R-HSA-9630221;Reactome: R-HSA-110328;Reactome: R-HSA-9630222;Reactome: R-HSA-110329	"Displacement of DNA glycosylase by APEX1";"Defective NTHL1 substrate processing";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective NTHL1 substrate binding";"Cleavage of the damaged pyrimidine"
APLA000315-PA	3	MetaCyc: PWY-6689;MetaCyc: PWY-7803;Reactome: R-HSA-6784531	"Trna splicing I";"Trna splicing II";"tRNA processing in the nucleus"
APLA007102-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA002668-PA	4	Reactome: R-HSA-189451;MetaCyc: PWY-5189;KEGG: 00860+4.2.1.75;MetaCyc: PWY-5188	"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)"
APLA009808-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA008808-PA	8	Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5685938;Reactome: R-HSA-8953750;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579	"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"HDR through Single Strand Annealing (SSA)";"Transcriptional Regulation by E2F6";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange"
APLA005858-PA	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
APLA000114-PA	5	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288	"Ion channel transport";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1"
APLA001547-PA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
APLA001112-PA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
APLA002483-PA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
APLA012901-PA	3	MetaCyc: PWY-6482;MetaCyc: PWY-7546;Reactome: R-HSA-5358493	"Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)";"Synthesis of diphthamide-EEF2"
APLA010500-PA	14	MetaCyc: PWY-7003;MetaCyc: PWY-8004;KEGG: 00680+4.2.1.11;MetaCyc: PWY-5723;MetaCyc: PWY-1622;KEGG: 00010+4.2.1.11;MetaCyc: PWY-2221;MetaCyc: PWY-5484;MetaCyc: PWY-6886;MetaCyc: PWY-6901;MetaCyc: PWY-7124;MetaCyc: PWY-6142;MetaCyc: PWY-1042;MetaCyc: PWY-7218	"Glycerol degradation to butanol";"Entner-Doudoroff pathway I";"Methane metabolism";"Rubisco shunt";"Formaldehyde assimilation I (serine pathway)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Glycolysis II (from fructose 6-phosphate)";"1-butanol autotrophic biosynthesis (engineered)";"Superpathway of glucose and xylose degradation";"Ethylene biosynthesis V (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)"
APLA010063-PA	14	MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7725;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-5972;MetaCyc: PWY-7619;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724	"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)"
APLA005338-PA	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
APLA014639-PA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
APLA001565-PA	1	Reactome: R-HSA-3295583	"TRP channels"
APLA006644-PA	5	Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-912446	"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"Meiotic recombination"
APLA000109-PA	2	Reactome: R-HSA-909733;Reactome: R-HSA-8983711	"Interferon alpha/beta signaling";"OAS antiviral response"
APLA009985-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA007931-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA003849-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA005060-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
APLA000345-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA008946-PA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
APLA015178-PA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
APLA013075-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA000682-PA	16	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
APLA001403-PA	5	Reactome: R-HSA-2426168;MetaCyc: PWY-7391;Reactome: R-HSA-191273;MetaCyc: PWY-922;KEGG: 00900+2.7.4.2	"Activation of gene expression by SREBF (SREBP)";"Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis";"Mevalonate pathway I";"Terpenoid backbone biosynthesis"
APLA014621-PA	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
APLA007063-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA003023-PA	2	Reactome: R-HSA-2142691;Reactome: R-HSA-2142700	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)"
APLA009827-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA002009-PA	4	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-8866654	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins"
APLA005076-PA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
APLA008743-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA003922-PA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
APLA008275-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA013006-PA	4	Reactome: R-HSA-1237112;MetaCyc: PWY-4361;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23	"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism"
APLA002710-PA	14	MetaCyc: PWY-7619;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-5972;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7601;Reactome: R-HSA-75876	"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs"
APLA001349-PA	4	MetaCyc: PWY-7807;Reactome: R-HSA-71737;KEGG: 00190+3.6.1.1;MetaCyc: PWY-7805	"Glyphosate degradation III";"Pyrophosphate hydrolysis";"Oxidative phosphorylation";"(aminomethyl)phosphonate degradation"
APLA014612-PA	3	MetaCyc: PWY-7210;KEGG: 00240+3.5.4.12;Reactome: R-HSA-499943	"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Interconversion of nucleotide di- and triphosphates"
APLA004154-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA012604-PA	2	Reactome: R-HSA-171319;Reactome: R-HSA-3214847	"Telomere Extension By Telomerase";"HATs acetylate histones"
APLA014686-PA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
APLA005665-PA	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
APLA013945-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA010062-PA	14	KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-5080	"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I"
APLA008339-PA	3	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15;Reactome: R-HSA-5628897	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism";"TP53 Regulates Metabolic Genes"
APLA000541-PA	1	Reactome: R-HSA-9640463	"Wax biosynthesis"
APLA011730-PA	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
APLA006839-PA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
APLA003018-PA	5	Reactome: R-HSA-162588;Reactome: R-HSA-917729;Reactome: R-HSA-9615710;Reactome: R-HSA-9610379;Reactome: R-HSA-174490	"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy";"HCMV Late Events";"Membrane binding and targetting of GAG proteins"
APLA009424-PA	10	Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938;Reactome: R-HSA-3108214;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554	"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)";"SUMOylation of DNA damage response and repair proteins";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
APLA013191-PA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
APLA010586-PA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
APLA005537-PA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
APLA003886-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA008006-PA	4	MetaCyc: PWY-6823;KEGG: 00790+4.6.1.17;KEGG: 00790+4.1.99.22;Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
APLA004469-PA	18	MetaCyc: PWY-7416;MetaCyc: PWY-6803;MetaCyc: PWY-7417;MetaCyc: PWY-7783;Reactome: R-HSA-1482788;MetaCyc: PWY-7409;MetaCyc: PWY-8051;Reactome: R-HSA-1482839;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1482801;Reactome: R-HSA-1482925;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482922;Reactome: R-HSA-1483166	"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidate, yeast)";"Plasmalogen degradation";"Acyl chain remodelling of PC";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Acyl chain remodelling of PE";"Arachidonic acid metabolism";"Ether lipid metabolism";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism";"Acyl chain remodelling of PS";"Acyl chain remodelling of PG";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Acyl chain remodelling of PI";"Synthesis of PA"
APLA006851-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA000543-PA	14	MetaCyc: PWY-7587;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-5981;KEGG: 00561+2.3.1.51;Reactome: R-HSA-1483166;MetaCyc: PWY-8053;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-7782;MetaCyc: PWY-7417;MetaCyc: PWY-8055;MetaCyc: PWY-5667;MetaCyc: PWY-7411	"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Glycerolipid metabolism";"Synthesis of PA";"Anandamide biosynthesis II";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Plasmalogen biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)"
APLA009445-PA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
APLA013374-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA006625-PA	1	Reactome: R-HSA-196783	"Coenzyme A biosynthesis"
APLA005789-PA	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection"
APLA015393-PA	1	Reactome: R-HSA-9640463	"Wax biosynthesis"
APLA009043-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA003528-PA	5	Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-5625740;Reactome: R-HSA-75035	"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate PKNs";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"
APLA014775-PA	6	Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-69052;Reactome: R-HSA-176187;Reactome: R-HSA-68962	"Orc1 removal from chromatin";"Unwinding of DNA";"Assembly of the pre-replicative complex";"Switching of origins to a post-replicative state";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex"
APLA012056-PA	1	Reactome: R-HSA-8964038	"LDL clearance"
APLA004639-PA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-68877	"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase"
APLA007134-PA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
APLA008714-PA	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
APLA010643-PA	33	Reactome: R-HSA-6784531;Reactome: R-HSA-9610379;Reactome: R-HSA-159227;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-4551638;Reactome: R-HSA-159231;Reactome: R-HSA-141444;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-68877;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-4570464;Reactome: R-HSA-9648025;Reactome: R-HSA-3232142;Reactome: R-HSA-4615885;Reactome: R-HSA-2500257;Reactome: R-HSA-170822	"tRNA processing in the nucleus";"HCMV Late Events";"Transport of the SLBP independent Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"Mitotic Prometaphase";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of RNA binding proteins";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA replication proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of Glucokinase by Glucokinase Regulatory Protein"
APLA014747-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA008236-PA	1	Reactome: R-HSA-427359	"SIRT1 negatively regulates rRNA expression"
APLA000614-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA007195-PA	5	MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7921	"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)"
APLA003946-PA	3	Reactome: R-HSA-9033241;Reactome: R-HSA-8866654;Reactome: R-HSA-9603798	"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Class I peroxisomal membrane protein import"
APLA013196-PA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
APLA007127-PA	2	Reactome: R-HSA-6785470;Reactome: R-HSA-6784531	"tRNA processing in the mitochondrion";"tRNA processing in the nucleus"
APLA010312-PA	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
APLA001304-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA006327-PA	14	MetaCyc: PWY-5104;MetaCyc: PWY-7767;MetaCyc: PWY-5103;MetaCyc: PWY-5101;KEGG: 00280+2.6.1.42;Reactome: R-HSA-70895;MetaCyc: PWY-5057;KEGG: 00270+2.6.1.42;KEGG: 00290+2.6.1.42;KEGG: 00770+2.6.1.42;KEGG: 00966+2.6.1.42;MetaCyc: PWY-5076;MetaCyc: PWY-5108;MetaCyc: PWY-5078	"L-isoleucine biosynthesis IV";"L-leucine degradation IV (Stickland reaction)";"L-isoleucine biosynthesis III";"L-isoleucine biosynthesis II";"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism";"L-valine degradation II";"Cysteine and methionine metabolism";"Valine, leucine and isoleucine biosynthesis";"Pantothenate and CoA biosynthesis";"Glucosinolate biosynthesis";"L-leucine degradation III";"L-isoleucine biosynthesis V";"L-isoleucine degradation II"
APLA014714-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA002219-PA	7	Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-73780;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
APLA000673-PA	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
APLA001662-PA	1	Reactome: R-HSA-350562	"Regulation of ornithine decarboxylase (ODC)"
APLA011066-PA	13	Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72689	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits"
APLA001459-PA	20	Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-5651801;Reactome: R-HSA-5655862;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-69473;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-110320;Reactome: R-HSA-6782135;Reactome: R-HSA-5693616;Reactome: R-HSA-69091;Reactome: R-HSA-5656121;Reactome: R-HSA-6782210	"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by POLK";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"G2/M DNA damage checkpoint";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Translesion Synthesis by POLH";"Dual incision in TC-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Polymerase switching";"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in TC-NER"
APLA011133-PA	2	Reactome: R-HSA-3214815;Reactome: R-HSA-427413	"HDACs deacetylate histones";"NoRC negatively regulates rRNA expression"
APLA008267-PA	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
APLA006256-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA011592-PA	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
APLA000598-PA	2	Reactome: R-HSA-5205685;Reactome: R-HSA-1268020	"Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import"
APLA012450-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA001038-PA	5	Reactome: R-HSA-5675221;KEGG: 04660+3.1.3.16;Reactome: R-HSA-112409;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"Negative regulation of MAPK pathway";"T cell receptor signaling pathway";"RAF-independent MAPK1/3 activation";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA014744-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA006952-PA	3	Reactome: R-HSA-391160;Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2	"Signal regulatory protein family interactions";"VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway"
APLA009103-PA	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
APLA012889-PA	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA004089-PA	3	Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-1358803	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Downregulation of ERBB2:ERBB3 signaling"
APLA001540-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA003557-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA002528-PA	10	KEGG: 04150+2.7.1.153;KEGG: 00562+2.7.1.153;Reactome: R-HSA-9027276;KEGG: 05165+2.7.1.153;KEGG: 04151+2.7.1.153;MetaCyc: PWY-6352;KEGG: 05170+2.7.1.153;KEGG: 05163+2.7.1.153;Reactome: R-HSA-1660499;KEGG: 04070+2.7.1.153	"mTOR signaling pathway";"Inositol phosphate metabolism";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"3-phosphoinositide biosynthesis";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system"
APLA001839-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA015025-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA009114-PA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
APLA012135-PA	5	Reactome: R-HSA-964975;KEGG: 00750+2.7.1.35;Reactome: R-HSA-6798695;MetaCyc: PWY-7204;MetaCyc: PWY-7282	"Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism";"Neutrophil degranulation";"Pyridoxal 5'-phosphate salvage II (plants)";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis"
APLA000068-PA	1	Reactome: R-HSA-373753	"Nephrin family interactions"
APLA014330-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA014099-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA012421-PA	16	Reactome: R-HSA-512988;Reactome: R-HSA-6811558;Reactome: R-HSA-389357;Reactome: R-HSA-416476;Reactome: R-HSA-194840;Reactome: R-HSA-1266695;Reactome: R-HSA-114604;Reactome: R-HSA-912631;Reactome: R-HSA-1660499;Reactome: R-HSA-2219530;Reactome: R-HSA-9009391;Reactome: R-HSA-912526;Reactome: R-HSA-1433557;Reactome: R-HSA-1257604;Reactome: R-HSA-388841;Reactome: R-HSA-8853659	"Interleukin-3, Interleukin-5 and GM-CSF signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"CD28 dependent PI3K/Akt signaling";"G alpha (q) signalling events";"Rho GTPase cycle";"Interleukin-7 signaling";"GPVI-mediated activation cascade";"Regulation of signaling by CBL";"Synthesis of PIPs at the plasma membrane";"Constitutive Signaling by Aberrant PI3K in Cancer";"Extra-nuclear estrogen signaling";"Interleukin receptor SHC signaling";"Signaling by SCF-KIT";"PIP3 activates AKT signaling";"Costimulation by the CD28 family";"RET signaling"
APLA000034-PA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
APLA001856-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA001168-PA	4	Reactome: R-HSA-4641257;Reactome: R-HSA-418594;Reactome: R-HSA-201681;Reactome: R-HSA-5689880	"Degradation of AXIN";"G alpha (i) signalling events";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases"
APLA008509-PA	7	Reactome: R-HSA-2644606;Reactome: R-HSA-2691232;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-2894862	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
APLA001198-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA006900-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA013078-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA002079-PA	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
APLA009362-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-8849473	"Major pathway of rRNA processing in the nucleolus and cytosol";"PTK6 Expression"
APLA000359-PA	18	MetaCyc: PWY-6545;Reactome: R-HSA-499943;MetaCyc: PWY-7222;MetaCyc: PWY-7221;MetaCyc: PWY-7205;MetaCyc: PWY-7176;KEGG: 00230+2.7.4.6;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7187;MetaCyc: PWY-7197;MetaCyc: PWY-7198;MetaCyc: PWY-7226;MetaCyc: PWY-7224;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7210;MetaCyc: PWY-7184;MetaCyc: PWY-7220;MetaCyc: PWY-7227	"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Guanosine ribonucleotides de novo biosynthesis";"CMP phosphorylation";"UTP and CTP de novo biosynthesis";"Purine metabolism";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine deoxyribonucleosides salvage";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis"
APLA001836-PA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
APLA011837-PA	26	Reactome: R-HSA-9013508;Reactome: R-HSA-1234158;Reactome: R-HSA-1912408;Reactome: R-HSA-1989781;Reactome: R-HSA-2894862;Reactome: R-HSA-201722;Reactome: R-HSA-9018519;Reactome: R-HSA-3371568;Reactome: R-HSA-3134973;Reactome: R-HSA-9013695;Reactome: R-HSA-918233;Reactome: R-HSA-1368082;Reactome: R-HSA-3214847;Reactome: R-HSA-9614657;Reactome: R-HSA-8866907;Reactome: R-HSA-933541;Reactome: R-HSA-5617472;Reactome: R-HSA-9617629;Reactome: R-HSA-2122947;Reactome: R-HSA-3899300;Reactome: R-HSA-400253;Reactome: R-HSA-8941856;Reactome: R-HSA-381340;Reactome: R-HSA-5621575;Reactome: R-HSA-2644606;Reactome: R-HSA-210744	"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of gene expression by Hypoxia-inducible Factor";"Pre-NOTCH Transcription and Translation";"PPARA activates gene expression";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Formation of the beta-catenin:TCF transactivating complex";"Estrogen-dependent gene expression";"Attenuation phase";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"NOTCH4 Intracellular Domain Regulates Transcription";"TRAF3-dependent IRF activation pathway";"RORA activates gene expression";"HATs acetylate histones";"FOXO-mediated transcription of cell death genes";"Activation of the TFAP2 (AP-2) family of transcription factors";"TRAF6 mediated IRF7 activation";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of FOXO transcriptional activity by acetylation";"NOTCH1 Intracellular Domain Regulates Transcription";"SUMOylation of transcription cofactors";"Circadian Clock";"RUNX3 regulates NOTCH signaling";"Transcriptional regulation of white adipocyte differentiation";"CD209 (DC-SIGN) signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
APLA000249-PA	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
APLA002826-PA	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
APLA012874-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA008703-PA	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
APLA001380-PA	10	Reactome: R-HSA-1912408;Reactome: R-HSA-350054;Reactome: R-HSA-9013508;Reactome: R-HSA-9013695;Reactome: R-HSA-2197563;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-8941856;Reactome: R-HSA-210744;Reactome: R-HSA-2644606	"Pre-NOTCH Transcription and Translation";"Notch-HLH transcription pathway";"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
APLA012489-PA	3	Reactome: R-HSA-749476;Reactome: R-HSA-76071;Reactome: R-HSA-6807505	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA polymerase II transcribes snRNA genes"
APLA009482-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA008529-PA	2	Reactome: R-HSA-204005;Reactome: R-HSA-5694530	"COPII-mediated vesicle transport";"Cargo concentration in the ER"
APLA012309-PA	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway"
APLA014194-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA006782-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA009541-PA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
APLA012574-PA	13	MetaCyc: PWY-7227;KEGG: 00240+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-7222;MetaCyc: PWY-7210;MetaCyc: PWY-7220;MetaCyc: PWY-7184;KEGG: 00230+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7226;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7198;KEGG: 00480+1.17.4.1	"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine metabolism";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Glutathione metabolism"
APLA011984-PA	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
APLA010656-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA004909-PA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
APLA013210-PA	16	Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-1799339	"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane"
APLA014795-PA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
APLA010280-PA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
APLA011864-PA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
APLA002184-PA	1	Reactome: R-HSA-71288	"Creatine metabolism"
APLA002092-PA	2	KEGG: 04070+2.7.11.13;Reactome: R-HSA-5625740	"Phosphatidylinositol signaling system";"RHO GTPases activate PKNs"
APLA012408-PA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
APLA000603-PA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
APLA013661-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA004494-PA	56	Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5678895;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-450408;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-174084;Reactome: R-HSA-4641257;Reactome: R-HSA-5689603	"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Neddylation";"Separation of Sister Chromatids";"Defective CFTR causes cystic fibrosis";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of AXIN";"UCH proteinases"
APLA004852-PA	1	Reactome: R-HSA-8949613	"Cristae formation"
APLA000879-PA	29	Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-167160;Reactome: R-HSA-73772;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-6782135;Reactome: R-HSA-77075;Reactome: R-HSA-75955;Reactome: R-HSA-6782210;Reactome: R-HSA-5696395;Reactome: R-HSA-73762;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-167161;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-674695	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Dual incision in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of Incision Complex in GG-NER";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"HIV Transcription Initiation";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the Early Elongation Complex";"mRNA Capping";"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Pre-transcription Events"
APLA014161-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA006721-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA005900-PA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
APLA004526-PA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
APLA001916-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA002216-PA	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
APLA001537-PA	1	Reactome: R-HSA-1474151	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"
APLA000955-PA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
APLA000162-PA	8	Reactome: R-HSA-8953750;Reactome: R-HSA-8943724;Reactome: R-HSA-9609690;Reactome: R-HSA-5617472;Reactome: R-HSA-212300;Reactome: R-HSA-2559580;Reactome: R-HSA-3214841;Reactome: R-HSA-4551638	"Transcriptional Regulation by E2F6";"Regulation of PTEN gene transcription";"HCMV Early Events";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PRC2 methylates histones and DNA";"Oxidative Stress Induced Senescence";"PKMTs methylate histone lysines";"SUMOylation of chromatin organization proteins"
APLA001160-PA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
APLA007660-PA	5	MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;Reactome: R-HSA-189085;MetaCyc: PWY-7822	"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Digestion of dietary carbohydrate";"Chitin degradation III (Serratia)"
APLA014546-PA	5	Reactome: R-HSA-8875360;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6807004;Reactome: R-HSA-182971	"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Negative regulation of MET activity";"EGFR downregulation"
APLA003055-PA	16	Reactome: R-HSA-176409;Reactome: R-HSA-8853884;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-176412;Reactome: R-HSA-174184;Reactome: R-HSA-2559582;Reactome: R-HSA-141430;Reactome: R-HSA-983168;Reactome: R-HSA-174048;Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-69017;Reactome: R-HSA-176408;Reactome: R-HSA-176407;Reactome: R-HSA-2467813	"APC/C:Cdc20 mediated degradation of mitotic proteins";"Transcriptional Regulation by VENTX";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"Phosphorylation of the APC/C";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Senescence-Associated Secretory Phenotype (SASP)";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Cyclin B";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of APC/C activators between G1/S and early anaphase";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Separation of Sister Chromatids"
APLA007117-PA	1	Reactome: R-HSA-114608	"Platelet degranulation"
APLA004512-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA010311-PA	8	KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-983712;KEGG: 00195+7.1.2.2;Reactome: R-HSA-1222556	"Oxidative phosphorylation";"ATP biosynthesis";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Ion channel transport";"Photosynthesis";"ROS and RNS production in phagocytes"
APLA011361-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA009503-PA	4	Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947	"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
APLA009928-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA012977-PA	56	Reactome: R-HSA-8939236;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5678895;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442	"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"Neddylation";"Defective CFTR causes cystic fibrosis";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs"
APLA004626-PA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
APLA000913-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA002825-PA	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
APLA009150-PA	5	Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-165181;Reactome: R-HSA-8854214	"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Inhibition of TSC complex formation by PKB";"TBC/RABGAPs"
APLA010150-PA	8	Reactome: R-HSA-5140745;Reactome: R-HSA-3928665;Reactome: R-HSA-432720;Reactome: R-HSA-196025;Reactome: R-HSA-190873;Reactome: R-HSA-5099900;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"EPH-ephrin mediated repulsion of cells";"Lysosome Vesicle Biogenesis";"Formation of annular gap junctions";"Gap junction degradation";"WNT5A-dependent internalization of FZD4";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
APLA010197-PA	24	Reactome: R-HSA-6811436;Reactome: R-HSA-437239;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-8852276;Reactome: R-HSA-8955332;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-9619483;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-3371497;Reactome: R-HSA-9609736	"COPI-independent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Aggrephagy";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Carboxyterminal post-translational modifications of tubulin";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Kinesins";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Activation of AMPK downstream of NMDARs";"Cilium Assembly";"COPI-mediated anterograde transport";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Gap junction assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Assembly and cell surface presentation of NMDA receptors"
APLA011020-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA008274-PA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
APLA010717-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA008998-PA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
APLA010647-PA	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
APLA000396-PA	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
APLA010275-PA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA000638-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA011087-PA	9	Reactome: R-HSA-3560801;Reactome: R-HSA-1971475;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253;Reactome: R-HSA-975634;Reactome: R-HSA-4420332;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096;Reactome: R-HSA-3560783	"Defective B3GAT3 causes JDSSDHD";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Retinoid metabolism and transport";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT2 causes exostoses 2";"HS-GAG degradation";"Defective B4GALT7 causes EDS, progeroid type"
APLA005795-PA	10	KEGG: 00600+3.2.1.23;Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2160916;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2206292;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23	"Sphingolipid metabolism";"HS-GAG degradation";"Neutrophil degranulation";"Hyaluronan uptake and degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"MPS VII - Sly syndrome";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
APLA010499-PA	14	KEGG: 00680+4.2.1.11;MetaCyc: PWY-8004;MetaCyc: PWY-7003;MetaCyc: PWY-5723;KEGG: 00010+4.2.1.11;MetaCyc: PWY-1622;MetaCyc: PWY-2221;MetaCyc: PWY-6886;MetaCyc: PWY-5484;MetaCyc: PWY-6901;MetaCyc: PWY-7124;MetaCyc: PWY-6142;MetaCyc: PWY-1042;MetaCyc: PWY-7218	"Methane metabolism";"Entner-Doudoroff pathway I";"Glycerol degradation to butanol";"Rubisco shunt";"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation I (serine pathway)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Superpathway of glucose and xylose degradation";"Ethylene biosynthesis V (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)"
APLA006099-PA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
APLA007552-PA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-68877	"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase"
APLA014127-PA	4	KEGG: 00260+4.2.1.22;Reactome: R-HSA-1614603;KEGG: 00270+4.2.1.22;MetaCyc: PWY-801	"Glycine, serine and threonine metabolism";"Cysteine formation from homocysteine";"Cysteine and methionine metabolism";"Homocysteine and cysteine interconversion"
APLA009901-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
APLA009234-PA	19	Reactome: R-HSA-975957;Reactome: R-HSA-3214858;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-6790901;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-8876725;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RMTs methylate histone arginines";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"rRNA modification in the nucleus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Protein methylation";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis"
APLA013214-PA	8	Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-68616;Reactome: R-HSA-68689;Reactome: R-HSA-68867	"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication";"CDC6 association with the ORC:origin complex";"Assembly of the pre-replicative complex"
APLA003844-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA010822-PA	6	MetaCyc: PWY-5744;MetaCyc: PWY-5789;MetaCyc: PWY-6722;Reactome: R-HSA-196780;MetaCyc: PWY-5743;MetaCyc: PWY-4381	"Glyoxylate assimilation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Candicidin biosynthesis";"Biotin transport and metabolism";"3-hydroxypropanoate cycle";"Fatty acid biosynthesis initiation (bacteria and plants)"
APLA000674-PA	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
APLA011728-PA	2	Reactome: R-HSA-389661;Reactome: R-HSA-9033241	"Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import"
APLA005319-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA002148-PA	4	MetaCyc: PWY-5737;MetaCyc: PWY-6922;KEGG: 00330+1.5.5.2;Reactome: R-HSA-70688	"(5R)-carbapenem carboxylate biosynthesis";"L-Ndelta-acetylornithine biosynthesis";"Arginine and proline metabolism";"Proline catabolism"
APLA006379-PA	13	Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination"
APLA001518-PA	6	MetaCyc: PWY-6527;Reactome: R-HSA-5609978;Reactome: R-HSA-70370;KEGG: 00520+2.7.7.12;KEGG: 00052+2.7.7.12;MetaCyc: PWY-6317	"Stachyose degradation";"Defective GALT can cause Galactosemia";"Galactose catabolism";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)"
APLA013660-PA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
APLA007680-PA	2	Reactome: R-HSA-70263;Reactome: R-HSA-70171	"Gluconeogenesis";"Glycolysis"
APLA003171-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA008944-PA	3	MetaCyc: PWY-5686;KEGG: 00240+1.3.5.2;Reactome: R-HSA-500753	"UMP biosynthesis I";"Pyrimidine metabolism";"Pyrimidine biosynthesis"
APLA006852-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA005581-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA015197-PA	6	Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-72689	"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits"
APLA008660-PA	7	Reactome: R-HSA-6784531;Reactome: R-HSA-203927;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-1655829;Reactome: R-HSA-168333;Reactome: R-HSA-165054	"tRNA processing in the nucleus";"MicroRNA (miRNA) biogenesis";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA"
APLA008403-PA	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
APLA009213-PA	13	Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72706	"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit"
APLA012319-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA011447-PA	27	Reactome: R-HSA-9610379;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-1169408;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-159227;Reactome: R-HSA-4085377;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-4570464;Reactome: R-HSA-3301854;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-4615885;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-3232142;Reactome: R-HSA-5578749;Reactome: R-HSA-3371453;Reactome: R-HSA-168333;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-170822;Reactome: R-HSA-5619107	"HCMV Late Events";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"ISG15 antiviral mechanism";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP independent Mature mRNA";"SUMOylation of SUMOylation proteins";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of RNA binding proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of ubiquitinylation proteins";"Transcriptional regulation by small RNAs";"Regulation of HSF1-mediated heat shock response";"NEP/NS2 Interacts with the Cellular Export Machinery";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"
APLA001817-PA	12	KEGG: 00511+3.2.1.25;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;KEGG: 00600+3.2.1.23;Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.23;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;Reactome: R-HSA-2206292;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2160916;KEGG: 00052+3.2.1.23	"Other glycan degradation";"Neutrophil degranulation";"HS-GAG degradation";"Sphingolipid metabolism";"Lysosomal oligosaccharide catabolism";"Other glycan degradation";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"MPS VII - Sly syndrome";"Glycosphingolipid biosynthesis - ganglio series";"Hyaluronan uptake and degradation";"Galactose metabolism"
APLA000400-PA	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
APLA007551-PA	5	MetaCyc: PWY-7282;KEGG: 00750+2.7.1.35;Reactome: R-HSA-6798695;Reactome: R-HSA-964975;MetaCyc: PWY-7204	"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Vitamin B6 metabolism";"Neutrophil degranulation";"Vitamins B6 activation to pyridoxal phosphate";"Pyridoxal 5'-phosphate salvage II (plants)"
APLA010778-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA001559-PA	1	Reactome: R-HSA-373752	"Netrin-1 signaling"
APLA006738-PA	2	KEGG: 00510+2.4.1.256;Reactome: R-HSA-446193	"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
APLA009657-PA	2	Reactome: R-HSA-4570571;Reactome: R-HSA-446193	"Defective RFT1 causes RFT1-CDG (CDG-1n)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
APLA000639-PA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
APLA006962-PA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
APLA011246-PA	5	Reactome: R-HSA-5579006;KEGG: 00270+6.3.2.3;MetaCyc: PWY-8043;KEGG: 00480+6.3.2.3;Reactome: R-HSA-174403	"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Cysteine and methionine metabolism";"Ophthalmate biosynthesis";"Glutathione metabolism";"Glutathione synthesis and recycling"
APLA003025-PA	1	Reactome: R-HSA-400253	"Circadian Clock"
APLA015230-PA	3	KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980;KEGG: 00195+7.1.2.2	"Oxidative phosphorylation";"ATP biosynthesis";"Photosynthesis"
APLA000225-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA014534-PA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
APLA000262-PA	17	MetaCyc: PWY-6611;MetaCyc: PWY-6627;MetaCyc: PWY-5532;MetaCyc: PWY-5695;MetaCyc: PWY-6609;KEGG: 00760+2.4.2.1;MetaCyc: PWY-6608;KEGG: 00230+2.4.2.1;MetaCyc: PWY-4202;MetaCyc: PWY-6644;MetaCyc: PWY-6620;MetaCyc: PWY-7179;Reactome: R-HSA-6798695;MetaCyc: PWY-7179-1;Reactome: R-HSA-74217;Reactome: R-HSA-74259;KEGG: 00240+2.4.2.1	"Adenine and adenosine salvage V";"Salinosporamide A biosynthesis";"Nucleoside and nucleotide degradation (archaea)";"Inosine 5'-phosphate degradation";"Adenine and adenosine salvage III";"Nicotinate and nicotinamide metabolism";"Guanosine nucleotides degradation III";"Purine metabolism";"Arsenate detoxification I (mammalian)";"Fluoroacetate and fluorothreonine biosynthesis";"Guanine and guanosine salvage";"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Purine deoxyribonucleosides degradation II";"Purine salvage";"Purine catabolism";"Pyrimidine metabolism"
APLA008155-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA014423-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA001668-PA	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
APLA011836-PA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
APLA003089-PA	13	MetaCyc: PWY-5690;MetaCyc: PWY-6969;MetaCyc: PWY-8086;KEGG: 00720+4.2.1.2;MetaCyc: PWY-7384;MetaCyc: PWY-7254;MetaCyc: PWY-561;MetaCyc: PWY-6728;Reactome: R-HSA-71403;KEGG: 00020+4.2.1.2;KEGG: 00620+4.2.1.2;MetaCyc: PWY-5913;MetaCyc: PWY-5392	"TCA cycle II (plants and fungi)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Carbon fixation pathways in prokaryotes";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle VII (acetate-producers)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Pyruvate metabolism";"Partial TCA cycle (obligate autotrophs)";"Reductive TCA cycle II"
APLA008494-PA	10	KEGG: 00240+2.1.1.45;MetaCyc: PWY-7198;MetaCyc: PWY-7187;Reactome: R-HSA-69205;KEGG: 00670+2.1.1.45;MetaCyc: PWY-3841;MetaCyc: PWY-7199;MetaCyc: PWY-7184;Reactome: R-HSA-499943;MetaCyc: PWY-7210	"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"G1/S-Specific Transcription";"One carbon pool by folate";"Folate transformations II (plants)";"Pyrimidine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP"
APLA012554-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA015298-PA	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
APLA003949-PA	6	MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782	"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis"
APLA008825-PA	4	Reactome: R-HSA-210991;Reactome: R-HSA-71240;Reactome: R-HSA-5660862;Reactome: R-HSA-352230	"Basigin interactions";"Tryptophan catabolism";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)";"Amino acid transport across the plasma membrane"
APLA009078-PA	12	KEGG: 00590+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8053;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-7417;MetaCyc: PWY-6803;MetaCyc: PWY-7416	"Arachidonic acid metabolism";"Linoleic acid metabolism";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis II";"Ether lipid metabolism";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylcholine, yeast)"
APLA003156-PA	2	Reactome: R-HSA-2022377;Reactome: R-HSA-6798695	"Metabolism of Angiotensinogen to Angiotensins";"Neutrophil degranulation"
APLA002447-PA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
APLA006726-PA	8	MetaCyc: PWY-6609;MetaCyc: PWY-7179;Reactome: R-HSA-6798695;KEGG: 00230+3.5.4.4;Reactome: R-HSA-5683826;MetaCyc: PWY-6611;MetaCyc: PWY-7179-1;Reactome: R-HSA-74217	"Adenine and adenosine salvage III";"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Purine metabolism";"Surfactant metabolism";"Adenine and adenosine salvage V";"Purine deoxyribonucleosides degradation II";"Purine salvage"
APLA003508-PA	3	Reactome: R-HSA-5632968;Reactome: R-HSA-5358565;Reactome: R-HSA-5632928	"Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH2"
APLA001187-PA	9	MetaCyc: PWY-7883;KEGG: 00603+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52	"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis"
APLA004141-PA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
APLA009841-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA000670-PA	9	Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-6804756;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-75953	"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation"
APLA009187-PA	6	Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-6791226	"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA007913-PA	5	KEGG: 00380+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2	"Tryptophan metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA";"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Lysine degradation"
APLA004123-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA004794-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA005576-PA	3	KEGG: 00520+1.1.1.271;Reactome: R-HSA-6787639;KEGG: 00051+1.1.1.271	"Amino sugar and nucleotide sugar metabolism";"GDP-fucose biosynthesis";"Fructose and mannose metabolism"
APLA004760-PA	1	Reactome: R-HSA-2142789	"Ubiquinol biosynthesis"
APLA002832-PA	29	Reactome: R-HSA-3108214;Reactome: R-HSA-5358606;Reactome: R-HSA-68962;Reactome: R-HSA-5693616;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5685938;Reactome: R-HSA-69166;Reactome: R-HSA-6782210;Reactome: R-HSA-5696395;Reactome: R-HSA-6783310;Reactome: R-HSA-5656121;Reactome: R-HSA-69473;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-6804756;Reactome: R-HSA-110312;Reactome: R-HSA-912446;Reactome: R-HSA-3371453;Reactome: R-HSA-3371511;Reactome: R-HSA-5696397;Reactome: R-HSA-5651801;Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-5685942;Reactome: R-HSA-174437;Reactome: R-HSA-110314;Reactome: R-HSA-5358565;Reactome: R-HSA-5655862	"SUMOylation of DNA damage response and repair proteins";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Activation of the pre-replicative complex";"Presynaptic phase of homologous DNA pairing and strand exchange";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"HDR through Single Strand Annealing (SSA)";"Removal of the Flap Intermediate";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of Incision Complex in GG-NER";"Fanconi Anemia Pathway";"Translesion synthesis by POLI";"G2/M DNA damage checkpoint";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Regulation of TP53 Activity through Phosphorylation";"Translesion synthesis by REV1";"Meiotic recombination";"Regulation of HSF1-mediated heat shock response";"HSF1 activation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate from the C-strand";"Recognition of DNA damage by PCNA-containing replication complex";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion synthesis by POLK"
APLA010986-PA	29	Reactome: R-HSA-6782210;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-112382;Reactome: R-HSA-6796648;Reactome: R-HSA-73772;Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-167161;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-76042;Reactome: R-HSA-73762	"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of RNA Pol II elongation complex";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV Transcription Initiation";"mRNA Capping";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation"
APLA007887-PA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
APLA000615-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA005246-PA	9	Reactome: R-HSA-167172;Reactome: R-HSA-6804756;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-674695	"Transcription of the HIV genome";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events"
APLA006822-PA	6	MetaCyc: PWY-6731;MetaCyc: PWY-7238;MetaCyc: PWY-6737;MetaCyc: PWY-5941;KEGG: 00500+2.4.1.1;Reactome: R-HSA-70221	"Starch degradation III";"Sucrose biosynthesis II";"Starch degradation V";"Glycogen degradation II";"Starch and sucrose metabolism";"Glycogen breakdown (glycogenolysis)"
APLA001538-PA	3	KEGG: 00230+2.7.1.20;MetaCyc: PWY-6619;Reactome: R-HSA-74217	"Purine metabolism";"Adenine and adenosine salvage VI";"Purine salvage"
APLA014986-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA002883-PA	6	Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-68877	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase"
APLA006450-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA007181-PA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
APLA007164-PA	5	KEGG: 00052+3.2.1.22;KEGG: 00561+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;MetaCyc: PWY-6527	"Galactose metabolism";"Glycerolipid metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Stachyose degradation"
APLA000287-PA	3	Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2206291	"HS-GAG degradation";"Neutrophil degranulation";"MPS IIIC - Sanfilippo syndrome C"
APLA007125-PA	6	Reactome: R-HSA-4793952;KEGG: 00510+2.4.1.143;MetaCyc: PWY-7920;Reactome: R-HSA-975578;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7426	"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)"
APLA003058-PA	2	Reactome: R-HSA-163841;KEGG: 00900+2.1.1.100	"Gamma carboxylation, hypusine formation and arylsulfatase activation";"Terpenoid backbone biosynthesis"
APLA011813-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA002389-PA	8	KEGG: 00052+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171	"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Glycolysis / Gluconeogenesis";"Neomycin, kanamycin and gentamicin biosynthesis";"Fructose and mannose metabolism";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Glycolysis"
APLA002281-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA011795-PA	12	Reactome: R-HSA-167200;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-6804756;Reactome: R-HSA-112382;Reactome: R-HSA-6796648;Reactome: R-HSA-167152;Reactome: R-HSA-167287	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Regulation of TP53 Activity through Phosphorylation";"Formation of RNA Pol II elongation complex";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery"
APLA007447-PA	4	Reactome: R-HSA-9615710;Reactome: R-HSA-9613829;Reactome: R-HSA-9646399;Reactome: R-HSA-3899300	"Late endosomal microautophagy";"Chaperone Mediated Autophagy";"Aggrephagy";"SUMOylation of transcription cofactors"
APLA008152-PA	9	Reactome: R-HSA-1368108;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-191859;Reactome: R-HSA-1368082;Reactome: R-HSA-400206;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"snRNP Assembly";"RORA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
APLA008750-PA	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
APLA012013-PA	4	Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
APLA003679-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA008280-PA	3	KEGG: 00680+3.1.2.12;MetaCyc: PWY-1801;Reactome: R-HSA-156590	"Methane metabolism";"Formaldehyde oxidation II (glutathione-dependent)";"Glutathione conjugation"
APLA008429-PA	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
APLA012508-PA	5	MetaCyc: PWY-5381;Reactome: R-HSA-196807;MetaCyc: PWY-7761;MetaCyc: PWY-5653;KEGG: 00760+2.7.7.18	"Pyridine nucleotide cycling (plants)";"Nicotinate metabolism";"NAD salvage pathway II (PNC IV cycle)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism"
APLA007154-PA	5	Reactome: R-HSA-983170;Reactome: R-HSA-2132295;Reactome: R-HSA-204005;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"MHC class II antigen presentation";"COPII-mediated vesicle transport";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
APLA012196-PA	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
APLA002480-PA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
APLA014094-PA	20	KEGG: 04151+2.7.11.1;Reactome: R-HSA-5218920;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5674400;Reactome: R-HSA-8943724;KEGG: 05165+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-3371571;KEGG: 05170+2.7.11.1;Reactome: R-HSA-166208;Reactome: R-HSA-6804757;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-1257604;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852	"PI3K-Akt signaling pathway";"VEGFR2 mediated vascular permeability";"Human cytomegalovirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of PTEN gene transcription";"Human papillomavirus infection";"CD28 dependent PI3K/Akt signaling";"HSF1-dependent transactivation";"Human immunodeficiency virus 1 infection";"mTORC1-mediated signalling";"Regulation of TP53 Degradation";"Thermogenesis";"mTOR signaling pathway";"Relaxin signaling pathway";"mTOR signalling";"Amino acids regulate mTORC1";"PIP3 activates AKT signaling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Macroautophagy"
APLA007993-PA	6	MetaCyc: PWY-622;MetaCyc: PWY-7900;KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.18;Reactome: R-HSA-189085	"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
APLA009125-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA008458-PA	2	Reactome: R-HSA-4086398;Reactome: R-HSA-418457	"Ca2+ pathway";"cGMP effects"
APLA003644-PA	1	Reactome: R-HSA-71384	"Ethanol oxidation"
APLA006690-PA	8	Reactome: R-HSA-69166;Reactome: R-HSA-113501;Reactome: R-HSA-68962;Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-174430;Reactome: R-HSA-174411;Reactome: R-HSA-69183	"Removal of the Flap Intermediate";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Activation of the pre-replicative complex";"Polymerase switching";"DNA replication initiation";"Telomere C-strand synthesis initiation";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand"
APLA004697-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA014338-PA	4	Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA008641-PA	3	Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-159230	"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"Transport of the SLBP Dependant Mature mRNA"
APLA002227-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA009723-PA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
APLA008684-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA013751-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA010365-PA	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
APLA013190-PA	20	Reactome: R-HSA-9033241;MetaCyc: PWY-7337;MetaCyc: PWY-7338;MetaCyc: PWY-735;MetaCyc: PWY-7340;MetaCyc: PWY-5136;MetaCyc: PWY-7288;MetaCyc: PWY-7726;KEGG: 00640+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7291;MetaCyc: PWY-7854;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7574;MetaCyc: PWY-7858;MetaCyc: PWY-6920;MetaCyc: PWY-7007;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7606	"Peroxisomal protein import";"10-cis-heptadecenoyl-CoA degradation (yeast)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Jasmonic acid biosynthesis";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Propanoate metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Fatty acid degradation";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"beta-Alanine metabolism";"Propanoyl-coa degradation II";"(5Z)-dodecenoate biosynthesis II";"6-gingerol analog biosynthesis (engineered)";"Methyl ketone biosynthesis (engineered)";"alpha-Linolenic acid metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)"
APLA004180-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA014770-PA	7	Reactome: R-HSA-70268;Reactome: R-HSA-389661;Reactome: R-HSA-204174;KEGG: 00620+2.3.1.12;KEGG: 00010+2.3.1.12;Reactome: R-HSA-5362517;KEGG: 00020+2.3.1.12	"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Signaling by Retinoic Acid";"Citrate cycle (TCA cycle)"
APLA008887-PA	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
APLA001644-PA	1	Reactome: R-HSA-2467813	"Separation of Sister Chromatids"
APLA003571-PA	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
APLA014320-PA	2	Reactome: R-HSA-446199;Reactome: R-HSA-4755609	"Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59"
APLA003100-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA000631-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA001624-PA	29	Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-167158;Reactome: R-HSA-674695;Reactome: R-HSA-73762;Reactome: R-HSA-76042;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-427413;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-167161;Reactome: R-HSA-167246;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-77075;Reactome: R-HSA-75955;Reactome: R-HSA-6782210;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-73772;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167160	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Formation of the Early Elongation Complex";"HIV Transcription Initiation";"Tat-mediated elongation of the HIV-1 transcript";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"RNA Polymerase I Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection"
APLA009374-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA014240-PA	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
APLA001194-PA	8	Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-8948747;Reactome: R-HSA-6804757;Reactome: R-HSA-5689880;Reactome: R-HSA-6782135;Reactome: R-HSA-8866652;Reactome: R-HSA-6782210	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Regulation of PTEN localization";"Regulation of TP53 Degradation";"Ub-specific processing proteases";"Dual incision in TC-NER";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Gap-filling DNA repair synthesis and ligation in TC-NER"
APLA003575-PA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
APLA013276-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA008576-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA001670-PA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
APLA004983-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA006200-PA	2	Reactome: R-HSA-3371599;Reactome: R-HSA-196780	"Defective HLCS causes multiple carboxylase deficiency";"Biotin transport and metabolism"
APLA003102-PA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957	"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA007396-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA010137-PA	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
APLA009495-PA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs"
APLA014471-PA	14	MetaCyc: PWY-7589;MetaCyc: PWY-7782;MetaCyc: PWY-6453;MetaCyc: PWY-7417;MetaCyc: PWY-8055;MetaCyc: PWY-7411;MetaCyc: PWY-5667;MetaCyc: PWY-8051;MetaCyc: PWY-7587;MetaCyc: PWY-5981;KEGG: 00564+2.3.1.51;KEGG: 00561+2.3.1.51;Reactome: R-HSA-1483166;MetaCyc: PWY-8053	"Palmitoleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Palmitoyl ethanolamide biosynthesis";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Synthesis of PA";"Anandamide biosynthesis II"
APLA013397-PA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
APLA006828-PA	6	MetaCyc: PWY-6731;MetaCyc: PWY-5941;MetaCyc: PWY-6737;KEGG: 00500+2.4.1.1;Reactome: R-HSA-70221;MetaCyc: PWY-7238	"Starch degradation III";"Glycogen degradation II";"Starch degradation V";"Starch and sucrose metabolism";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II"
APLA007018-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA014306-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA005669-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA007908-PA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
APLA002139-PA	1	KEGG: 04150+2.7.11.24	"mTOR signaling pathway"
APLA000555-PA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
APLA009849-PA	13	MetaCyc: PWY-7206;KEGG: 00230+3.6.1.66;KEGG: 00770+3.6.1.9;MetaCyc: PWY-7821;Reactome: R-HSA-74259;MetaCyc: PWY-7184;KEGG: 00230+3.6.1.9;KEGG: 00760+3.6.1.9;KEGG: 00500+3.6.1.9;MetaCyc: PWY-6545;KEGG: 00240+3.6.1.9;MetaCyc: PWY-7187;KEGG: 00740+3.6.1.9	"Pyrimidine deoxyribonucleotides dephosphorylation";"Purine metabolism";"Pantothenate and CoA biosynthesis";"Tunicamycin biosynthesis";"Purine catabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Nicotinate and nicotinamide metabolism";"Starch and sucrose metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Riboflavin metabolism"
APLA007601-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA005249-PA	9	Reactome: R-HSA-4420097;Reactome: R-HSA-2871796;Reactome: R-HSA-114604;Reactome: R-HSA-5218920;Reactome: R-HSA-193648;Reactome: R-HSA-2029482;Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-2871809	"VEGFA-VEGFR2 Pathway";"FCERI mediated MAPK activation";"GPVI-mediated activation cascade";"VEGFR2 mediated vascular permeability";"NRAGE signals death through JNK";"Regulation of actin dynamics for phagocytic cup formation";"Rho GTPase cycle";"G alpha (12/13) signalling events";"FCERI mediated Ca+2 mobilization"
APLA014952-PA	4	KEGG: 00473+5.1.1.1;MetaCyc: PWY-8040;MetaCyc: PWY-7383;MetaCyc: PWY-8072	"D-Alanine metabolism";"Ansatrienin biosynthesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Alanine racemization"
APLA011035-PA	3	Reactome: R-HSA-110314;Reactome: R-HSA-5689880;Reactome: R-HSA-6783310	"Recognition of DNA damage by PCNA-containing replication complex";"Ub-specific processing proteases";"Fanconi Anemia Pathway"
APLA006933-PA	6	Reactome: R-HSA-69052;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-68867	"Switching of origins to a post-replicative state";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA";"Assembly of the pre-replicative complex"
APLA009740-PA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
APLA009513-PA	3	Reactome: R-HSA-1483213;KEGG: 00564+4.1.1.65;MetaCyc: PWY-5669	"Synthesis of PE";"Glycerophospholipid metabolism";"Phosphatidylserine and phosphatidylethanolamine biosynthesis I"
APLA003262-PA	14	Reactome: R-HSA-611105;KEGG: 00020+1.3.5.1;MetaCyc: PWY-7254;KEGG: 00720+1.3.5.1;MetaCyc: PWY-5690;MetaCyc: PWY-6969;MetaCyc: PWY-6728;KEGG: 00650+1.3.5.1;Reactome: R-HSA-71403;MetaCyc: PWY-4302;MetaCyc: PWY-561;MetaCyc: PWY-7279;MetaCyc: PWY-3781;KEGG: 00190+1.3.5.1	"Respiratory electron transport";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle";"Butanoate metabolism";"Citric acid cycle (TCA cycle)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration I (cytochrome c)";"Oxidative phosphorylation"
APLA013213-PA	5	KEGG: 00620+4.1.1.32;KEGG: 00020+4.1.1.32;Reactome: R-HSA-70263;KEGG: 00010+4.1.1.32;MetaCyc: PWY-7383	"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)"
APLA013069-PA	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
APLA012563-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA014096-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA005140-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA010434-PA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-6811436	"RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic"
APLA001970-PA	33	MetaCyc: PWY-7118;MetaCyc: PWY-6313;MetaCyc: PWY-5078;MetaCyc: PWY-7798;MetaCyc: PWY-7396;MetaCyc: PWY-6871;MetaCyc: PWY-5057;KEGG: 00260+1.1.1.1;MetaCyc: PWY-5751;MetaCyc: PWY-5486;MetaCyc: PWY-7013;KEGG: 00350+1.1.1.1;MetaCyc: PWY-7111;MetaCyc: PWY-6333;KEGG: 00592+1.1.1.1;Reactome: R-HSA-71384;KEGG: 00830+1.1.1.1;MetaCyc: PWY-5076;KEGG: 00625+1.1.1.1;KEGG: 00980+1.1.1.1;MetaCyc: PWY-5079;KEGG: 00626+1.1.1.1;MetaCyc: PWY-6802;KEGG: 00010+1.1.1.1;MetaCyc: PWY-5480;KEGG: 00982+1.1.1.1;MetaCyc: PWY-6587;MetaCyc: PWY-5082;MetaCyc: PWY-6342;KEGG: 00071+1.1.1.1;KEGG: 00680+1.1.1.284;MetaCyc: PWY-1801;MetaCyc: PWY-3162	"Chitin degradation to ethanol";"Serotonin degradation";"L-isoleucine degradation II";"Protein S-nitrosylation and denitrosylation";"Butanol and isobutanol biosynthesis (engineered)";"3-methylbutanol biosynthesis (engineered)";"L-valine degradation II";"Glycine, serine and threonine metabolism";"Phenylethanol biosynthesis";"Pyruvate fermentation to ethanol II";"(S)-propane-1,2-diol degradation";"Tyrosine metabolism";"Pyruvate fermentation to isobutanol (engineered)";"Acetaldehyde biosynthesis I";"alpha-Linolenic acid metabolism";"Ethanol oxidation";"Retinol metabolism";"L-leucine degradation III";"Chloroalkane and chloroalkene degradation";"Metabolism of xenobiotics by cytochrome P450";"L-phenylalanine degradation III";"Naphthalene degradation";"Salidroside biosynthesis";"Glycolysis / Gluconeogenesis";"Pyruvate fermentation to ethanol I";"Drug metabolism - cytochrome P450";"Pyruvate fermentation to ethanol III";"L-methionine degradation III";"Noradrenaline and adrenaline degradation";"Fatty acid degradation";"Methane metabolism";"Formaldehyde oxidation II (glutathione-dependent)";"L-tryptophan degradation V (side chain pathway)"
APLA000168-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA010598-PA	6	Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-69052;Reactome: R-HSA-176187;Reactome: R-HSA-68962	"Orc1 removal from chromatin";"Unwinding of DNA";"Assembly of the pre-replicative complex";"Switching of origins to a post-replicative state";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex"
APLA006117-PA	7	Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2691232;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2660826	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant"
APLA007052-PA	2	Reactome: R-HSA-983168;Reactome: R-HSA-110320	"Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH"
APLA011710-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA013208-PA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5689880	"UCH proteinases";"Ub-specific processing proteases"
APLA001587-PA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
APLA011333-PA	13	Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-975957	"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA014042-PA	6	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-975957;Reactome: R-HSA-9010553	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
APLA014999-PA	32	Reactome: R-HSA-167242;Reactome: R-HSA-9018519;Reactome: R-HSA-167238;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648;Reactome: R-HSA-72165;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-72203;Reactome: R-HSA-167161;Reactome: R-HSA-168325;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-8851708;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-72163;Reactome: R-HSA-167160;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-77075	"Abortive elongation of HIV-1 transcript in the absence of Tat";"Estrogen-dependent gene expression";"Pausing and recovery of Tat-mediated HIV elongation";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Splicing - Minor Pathway";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA";"HIV Transcription Initiation";"Viral Messenger RNA Synthesis";"Formation of the Early Elongation Complex";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"mRNA Splicing - Major Pathway";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE"
APLA015391-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA003938-PA	2	KEGG: 00450+6.1.1.10;KEGG: 00970+6.1.1.10	"Selenocompound metabolism";"Aminoacyl-tRNA biosynthesis"
APLA006443-PA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
APLA014842-PA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
APLA014896-PA	40	KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;MetaCyc: PWY-7778;MetaCyc: PWY-5138;MetaCyc: PWY-7654;MetaCyc: PWY-6944;MetaCyc: PWY-7656;MetaCyc: PWY-6863;KEGG: 00592+4.2.1.17;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-5109;MetaCyc: PWY-7401;MetaCyc: PWY-5136;KEGG: 00623+1.1.1.35;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-6883;MetaCyc: PWY-7216;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7094;KEGG: 00360+4.2.1.17;MetaCyc: PWY-7779;MetaCyc: PWY-5789;MetaCyc: PWY-7007;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-7606;KEGG: 00640+4.2.1.17;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00410+4.2.1.17;MetaCyc: PWY-7726;MetaCyc: PWY-6583;MetaCyc: PWY-6945;KEGG: 00930+4.2.1.17+1.1.1.35;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17	"Valine, leucine and isoleucine degradation";"4-hydroxybenzoate biosynthesis III (plants)";"2-methylpropene degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Androstenedione degradation";"Spodoptera littoralis pheromone biosynthesis";"Pyruvate fermentation to hexanol (engineered)";"alpha-Linolenic acid metabolism";"Geraniol degradation";"Fermentation to 2-methylbutanoate";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Fatty acid beta-oxidation II (plant peroxisome)";"Toluene degradation";"Tryptophan metabolism";"Pyruvate fermentation to butanol II (engineered)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Carbon fixation pathways in prokaryotes";"Glutaryl-coa degradation";"Fatty acid degradation";"Benzoyl-coa degradation I (aerobic)";"Fatty acid elongation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Aminobenzoate degradation";"Fatty acid salvage";"Phenylalanine metabolism";"Methyl tert-butyl ether degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Methyl ketone biosynthesis (engineered)";"Butanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Propanoate metabolism";"Benzoate degradation";"beta-Alanine metabolism";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Pyruvate fermentation to butanol I";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Caprolactam degradation";"Lysine degradation";"Limonene and pinene degradation"
APLA002581-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA003883-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA009588-PA	6	KEGG: 00380+1.11.1.6;Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;Reactome: R-HSA-6798695;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241	"Tryptophan metabolism";"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Neutrophil degranulation";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import"
APLA014778-PA	2	MetaCyc: PWY-6281;KEGG: 00450+2.7.9.3	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocompound metabolism"
APLA012902-PA	5	Reactome: R-HSA-380994;Reactome: R-HSA-9648895;Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;KEGG: 00250+6.3.5.4	"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK1 (HRI) to heme deficiency";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism"
APLA006660-PA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
APLA000681-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-6783310	"Protein ubiquitination";"Fanconi Anemia Pathway"
APLA008209-PA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
APLA013956-PA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
APLA002124-PA	4	Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394	"Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER"
APLA009561-PA	8	KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-428540	"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Activation of RAC1"
APLA010067-PA	14	Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7724;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5972;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-7619	"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis"
APLA011528-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA003393-PA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1482798	"Mitochondrial protein import";"Acyl chain remodeling of CL"
APLA008421-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA009832-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA000025-PA	8	Reactome: R-HSA-6791461;KEGG: 00710+5.3.1.6;KEGG: 00030+5.3.1.6;KEGG: 00051+5.3.1.6;MetaCyc: PWY-1861;Reactome: R-HSA-5659996;Reactome: R-HSA-71336;MetaCyc: PWY-5723	"RPIA deficiency: failed conversion of RU5P to R5P";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway";"Fructose and mannose metabolism";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"RPIA deficiency: failed conversion of R5P to RU5P";"Pentose phosphate pathway";"Rubisco shunt"
APLA004653-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA001965-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA010863-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA004846-PA	13	MetaCyc: PWY-5537;MetaCyc: PWY-5392;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-7384;MetaCyc: PWY-5538;MetaCyc: PWY-5690;MetaCyc: PWY-6969;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;Reactome: R-HSA-71403;MetaCyc: PWY-6728;KEGG: 00660+6.2.1.5	"Pyruvate fermentation to acetate V";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"Partial TCA cycle (obligate autotrophs)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Pyruvate fermentation to acetate VI";"TCA cycle II (plants and fungi)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"C5-Branched dibasic acid metabolism"
APLA000337-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA002834-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA005000-PA	20	Reactome: R-HSA-5696397;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-5651801;Reactome: R-HSA-5655862;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-6782135;Reactome: R-HSA-5685938;Reactome: R-HSA-110320;Reactome: R-HSA-5693616;Reactome: R-HSA-69091;Reactome: R-HSA-5656121;Reactome: R-HSA-6782210;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-5696400;Reactome: R-HSA-69473;Reactome: R-HSA-5656169;Reactome: R-HSA-6804756	"Gap-filling DNA repair synthesis and ligation in GG-NER";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by POLK";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Dual incision in TC-NER";"HDR through Single Strand Annealing (SSA)";"Translesion Synthesis by POLH";"Presynaptic phase of homologous DNA pairing and strand exchange";"Polymerase switching";"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"Dual Incision in GG-NER";"G2/M DNA damage checkpoint";"Termination of translesion DNA synthesis";"Regulation of TP53 Activity through Phosphorylation"
APLA003496-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA008988-PA	8	Reactome: R-HSA-163754;KEGG: 00030+2.2.1.2;Reactome: R-HSA-6791462;Reactome: R-HSA-6791055;MetaCyc: PWY-1861;Reactome: R-HSA-8950505;Reactome: R-HSA-71336;MetaCyc: PWY-5723	"Insulin effects increased synthesis of Xylulose-5-Phosphate";"Pentose phosphate pathway";"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P";"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Pentose phosphate pathway";"Rubisco shunt"
APLA005402-PA	4	Reactome: R-HSA-5358493;MetaCyc: PWY-6482;MetaCyc: PWY-7546;Reactome: R-HSA-8849175	"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)";"Threonine catabolism"
APLA001217-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA011103-PA	5	Reactome: R-HSA-933541;Reactome: R-HSA-9013973;Reactome: R-HSA-918233;Reactome: R-HSA-936964;Reactome: R-HSA-936440	"TRAF6 mediated IRF7 activation";"TICAM1-dependent activation of IRF3/IRF7";"TRAF3-dependent IRF activation pathway";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Negative regulators of DDX58/IFIH1 signaling"
APLA014036-PA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
APLA004851-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA004238-PA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
APLA011141-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA002404-PA	4	Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825	"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis"
APLA000546-PA	6	MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis"
APLA014472-PA	2	Reactome: R-HSA-532668;Reactome: R-HSA-6798695	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Neutrophil degranulation"
APLA012143-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA008286-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA014130-PA	14	Reactome: R-HSA-1912408;Reactome: R-HSA-9029569;Reactome: R-HSA-5628897;Reactome: R-HSA-8934593;Reactome: R-HSA-203927;Reactome: R-HSA-8943723;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-426496;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-426486;Reactome: R-HSA-8986944	"Pre-NOTCH Transcription and Translation";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"TP53 Regulates Metabolic Genes";"Regulation of RUNX1 Expression and Activity";"MicroRNA (miRNA) biogenesis";"Regulation of PTEN mRNA translation";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Post-transcriptional silencing by small RNAs";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Small interfering RNA (siRNA) biogenesis";"Transcriptional Regulation by MECP2"
APLA015353-PA	2	KEGG: 00770+6.3.2.5;Reactome: R-HSA-196783	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
APLA011993-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
APLA011089-PA	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
APLA005523-PA	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
APLA014390-PA	5	KEGG: 00740+2.7.1.26;Reactome: R-HSA-196843;MetaCyc: PWY-7863;MetaCyc: PWY-5523;MetaCyc: PWY-6168	"Riboflavin metabolism";"Vitamin B2 (riboflavin) metabolism";"Roseoflavin biosynthesis";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Flavin biosynthesis III (fungi)"
APLA000365-PA	4	Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)"
APLA011460-PA	7	Reactome: R-HSA-1483148;KEGG: 00565+3.1.4.4;MetaCyc: PWY-7039;MetaCyc: PWY-3561;Reactome: R-HSA-2029485;Reactome: R-HSA-1483166;KEGG: 00564+3.1.4.4	"Synthesis of PG";"Ether lipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Choline biosynthesis III";"Role of phospholipids in phagocytosis";"Synthesis of PA";"Glycerophospholipid metabolism"
APLA004186-PA	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
APLA014492-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA014838-PA	3	Reactome: R-HSA-9033241;Reactome: R-HSA-8866654;Reactome: R-HSA-9603798	"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Class I peroxisomal membrane protein import"
APLA009730-PA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
APLA002359-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA007916-PA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
APLA004250-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA006750-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA009349-PA	7	Reactome: R-HSA-6798695;Reactome: R-HSA-5620922;Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-390471	"Neutrophil degranulation";"BBSome-mediated cargo-targeting to cilium";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Association of TriC/CCT with target proteins during biosynthesis"
APLA011501-PA	1	Reactome: R-HSA-5250924	"B-WICH complex positively regulates rRNA expression"
APLA002827-PA	1	MetaCyc: PWY-7533	"Gliotoxin biosynthesis"
APLA009871-PA	14	MetaCyc: PWY-5972;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7724;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7725;MetaCyc: PWY-8041	"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis"
APLA000335-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA014255-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA005783-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA007933-PA	1	Reactome: R-HSA-379716	"Cytosolic tRNA aminoacylation"
APLA007962-PA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
APLA007145-PA	10	Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-6807505;Reactome: R-HSA-167161;Reactome: R-HSA-9018519;Reactome: R-HSA-75953;Reactome: R-HSA-674695	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA polymerase II transcribes snRNA genes";"HIV Transcription Initiation";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events"
APLA009670-PA	7	Reactome: R-HSA-5578999;KEGG: 00480+6.3.2.2;Reactome: R-HSA-174403;MetaCyc: PWY-6840;KEGG: 00270+6.3.2.2;MetaCyc: PWY-7255;MetaCyc: PWY-8043	"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Glutathione metabolism";"Glutathione synthesis and recycling";"Homoglutathione biosynthesis";"Cysteine and methionine metabolism";"Ergothioneine biosynthesis I (bacteria)";"Ophthalmate biosynthesis"
APLA012581-PA	2	Reactome: R-HSA-204005;Reactome: R-HSA-5694530	"COPII-mediated vesicle transport";"Cargo concentration in the ER"
APLA014461-PA	5	Reactome: R-HSA-71336;Reactome: R-HSA-6798695;MetaCyc: PWY-8060;KEGG: 00030+4.1.2.4;MetaCyc: PWY-7180	"Pentose phosphate pathway";"Neutrophil degranulation";"2-deoxy-D-ribose degradation I";"Pentose phosphate pathway";"2-deoxy-alpha-D-ribose 1-phosphate degradation"
APLA007096-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA003808-PA	7	KEGG: 00562+3.1.4.11;MetaCyc: PWY-8052;Reactome: R-HSA-1855204;MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351	"Inositol phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis"
APLA010870-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA003602-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA008326-PA	7	Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-2565942	"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition"
APLA006915-PA	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
APLA001623-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA009968-PA	3	KEGG: 00480+4.3.2.7;MetaCyc: PWY-7942;Reactome: R-HSA-174403	"Glutathione metabolism";"5-oxo-L-proline metabolism";"Glutathione synthesis and recycling"
APLA000120-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA015327-PA	6	Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6;KEGG: 00380+1.11.1.6;Reactome: R-HSA-6798695;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685	"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism";"Tryptophan metabolism";"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species"
APLA010703-PA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
APLA010094-PA	1	Reactome: R-HSA-3214815	"HDACs deacetylate histones"
APLA009421-PA	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
APLA002315-PA	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
APLA014259-PA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
APLA014985-PA	13	Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-9633012	"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
APLA002493-PA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
APLA008361-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA013767-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA006691-PA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
APLA012510-PA	4	Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA013547-PA	8	Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-165054;Reactome: R-HSA-5663220	"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Rev-mediated nuclear export of HIV RNA";"RHO GTPases Activate Formins"
APLA005469-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA001487-PA	7	Reactome: R-HSA-204174;KEGG: 00620+1.2.4.1;KEGG: 00020+1.2.4.1;Reactome: R-HSA-5362517;Reactome: R-HSA-70268;Reactome: R-HSA-389661;KEGG: 00010+1.2.4.1	"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Signaling by Retinoic Acid";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Glycolysis / Gluconeogenesis"
APLA014430-PA	5	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72165;Reactome: R-HSA-72163;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing"
APLA008230-PA	4	Reactome: R-HSA-2470946;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257	"Cohesin Loading onto Chromatin";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion"
APLA006012-PA	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440	"RAB GEFs exchange GTP for GDP on RABs";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network"
APLA011918-PA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
APLA012891-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA013251-PA	4	Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219	"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis"
APLA008150-PA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
APLA003469-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA007858-PA	26	Reactome: R-HSA-983189;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-5617833;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-389960;Reactome: R-HSA-3371497;Reactome: R-HSA-9609736;Reactome: R-HSA-389977;Reactome: R-HSA-6811436;Reactome: R-HSA-437239;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-8955332;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257	"Kinesins";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Cilium Assembly";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Gap junction assembly";"Formation of tubulin folding intermediates by CCT/TriC";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Assembly and cell surface presentation of NMDA receptors";"Post-chaperonin tubulin folding pathway";"COPI-independent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Separation of Sister Chromatids";"Aggrephagy";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"Carboxyterminal post-translational modifications of tubulin";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion"
APLA004549-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA008128-PA	4	Reactome: R-HSA-1971475;KEGG: 00534+2.4.2.26;MetaCyc: PWY-6557;KEGG: 00532+2.4.2.26	"A tetrasaccharide linker sequence is required for GAG synthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Glycosaminoglycan-protein linkage region biosynthesis";"Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate"
APLA002636-PA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
APLA011704-PA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA009388-PA	4	Reactome: R-HSA-112308;Reactome: R-HSA-5576893;Reactome: R-HSA-419037;Reactome: R-HSA-5576892	"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase";"NCAM1 interactions";"Phase 0 - rapid depolarisation"
APLA011721-PA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
APLA005473-PA	3	MetaCyc: PWY-7833;Reactome: R-HSA-9033807;MetaCyc: PWY-7831	"Biosynthesis of Lewis epitopes (H. pylori)";"ABO blood group biosynthesis";"ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide"
APLA000043-PA	5	Reactome: R-HSA-381183;Reactome: R-HSA-380994;Reactome: R-HSA-9614657;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168	"ATF6 (ATF6-alpha) activates chaperone genes";"ATF4 activates genes in response to endoplasmic reticulum stress";"FOXO-mediated transcription of cell death genes";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)"
APLA011132-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA004886-PA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
APLA005834-PA	1	Reactome: R-HSA-6806664	"Metabolism of vitamin K"
APLA005701-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA015495-PA	1	Reactome: R-HSA-1632852	"Macroautophagy"
APLA011446-PA	7	Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-156711;Reactome: R-HSA-69202;Reactome: R-HSA-69205	"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"Polo-like kinase mediated events";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription"
APLA003898-PA	3	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
APLA015000-PA	32	Reactome: R-HSA-6803529;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167160;Reactome: R-HSA-8851708;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-72163;Reactome: R-HSA-167290;Reactome: R-HSA-9018519;Reactome: R-HSA-167238;Reactome: R-HSA-167242;Reactome: R-HSA-72165;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648	"FGFR2 alternative splicing";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"mRNA Capping";"Formation of the Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Splicing - Major Pathway";"Pausing and recovery of HIV elongation";"Estrogen-dependent gene expression";"Pausing and recovery of Tat-mediated HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Minor Pathway";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes"
APLA008679-PA	2	Reactome: R-HSA-432720;Reactome: R-HSA-432722	"Lysosome Vesicle Biogenesis";"Golgi Associated Vesicle Biogenesis"
APLA008464-PA	6	KEGG: 00020+4.2.1.3;KEGG: 00720+4.2.1.3;KEGG: 00630+4.2.1.3;Reactome: R-HSA-71403;Reactome: R-HSA-1268020;KEGG: 00290+4.2.1.33	"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism";"Citric acid cycle (TCA cycle)";"Mitochondrial protein import";"Valine, leucine and isoleucine biosynthesis"
APLA006970-PA	5	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-6784531	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"tRNA processing in the nucleus"
APLA000743-PA	52	Reactome: R-HSA-9018519;Reactome: R-HSA-167238;Reactome: R-HSA-76066;Reactome: R-HSA-73762;Reactome: R-HSA-76071;Reactome: R-HSA-167242;Reactome: R-HSA-1834949;Reactome: R-HSA-72165;Reactome: R-HSA-6782210;Reactome: R-HSA-73780;Reactome: R-HSA-6781827;Reactome: R-HSA-749476;Reactome: R-HSA-5617472;Reactome: R-HSA-6796648;Reactome: R-HSA-73772;Reactome: R-HSA-6807505;Reactome: R-HSA-75953;Reactome: R-HSA-5578749;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-6803529;Reactome: R-HSA-76042;Reactome: R-HSA-5250924;Reactome: R-HSA-167172;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-72203;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-73863;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-167246;Reactome: R-HSA-6782135;Reactome: R-HSA-73980;Reactome: R-HSA-77075;Reactome: R-HSA-75955;Reactome: R-HSA-5601884;Reactome: R-HSA-76061;Reactome: R-HSA-167290;Reactome: R-HSA-72163;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-8851708;Reactome: R-HSA-203927;Reactome: R-HSA-167160;Reactome: R-HSA-112382	"Estrogen-dependent gene expression";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase I Transcription Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Cytosolic sensors of pathogen-associated DNA";"mRNA Splicing - Minor Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase III Chain Elongation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase III Abortive And Retractive Initiation";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Promoter Escape";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Initiation";"Transcriptional regulation by small RNAs";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"FGFR2 alternative splicing";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"B-WICH complex positively regulates rRNA expression";"Transcription of the HIV genome";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"Processing of Capped Intron-Containing Pre-mRNA";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Transcription Termination";"Formation of the Early Elongation Complex";"mRNA Capping";"Tat-mediated elongation of the HIV-1 transcript";"Dual incision in TC-NER";"RNA Polymerase III Transcription Termination";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Elongation";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Pausing and recovery of HIV elongation";"mRNA Splicing - Major Pathway";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Signaling by FGFR2 IIIa TM";"MicroRNA (miRNA) biogenesis";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of RNA Pol II elongation complex"
APLA010535-PA	12	KEGG: 04714+2.7.11.1;Reactome: R-HSA-1632852;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9619483;KEGG: 04151+2.7.11.1	"Thermogenesis";"Macroautophagy";"mTOR signaling pathway";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Activation of AMPK downstream of NMDARs";"PI3K-Akt signaling pathway"
APLA004356-PA	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
APLA003488-PA	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
APLA015095-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA004838-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA007751-PA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
APLA015031-PA	26	Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-389960;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-983189;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-6811434;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-8852276;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-389977	"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"HCMV Early Events";"Gap junction assembly";"Formation of tubulin folding intermediates by CCT/TriC";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Cilium Assembly";"COPI-mediated anterograde transport";"Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Kinesins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"COPI-dependent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"Post-chaperonin tubulin folding pathway"
APLA000049-PA	5	Reactome: R-HSA-390471;Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-389957	"Association of TriC/CCT with target proteins during biosynthesis";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC"
APLA010000-PA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
APLA014545-PA	29	Reactome: R-HSA-5656169;Reactome: R-HSA-69473;Reactome: R-HSA-5696400;Reactome: R-HSA-6804756;Reactome: R-HSA-110312;Reactome: R-HSA-69166;Reactome: R-HSA-6782210;Reactome: R-HSA-5696395;Reactome: R-HSA-6783310;Reactome: R-HSA-5656121;Reactome: R-HSA-3108214;Reactome: R-HSA-5358606;Reactome: R-HSA-68962;Reactome: R-HSA-5693616;Reactome: R-HSA-110320;Reactome: R-HSA-5685938;Reactome: R-HSA-6782135;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-174437;Reactome: R-HSA-5358565;Reactome: R-HSA-5655862;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-5651801;Reactome: R-HSA-3371511;Reactome: R-HSA-5696397;Reactome: R-HSA-912446;Reactome: R-HSA-3371453	"Termination of translesion DNA synthesis";"G2/M DNA damage checkpoint";"Dual Incision in GG-NER";"Regulation of TP53 Activity through Phosphorylation";"Translesion synthesis by REV1";"Removal of the Flap Intermediate";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of Incision Complex in GG-NER";"Fanconi Anemia Pathway";"Translesion synthesis by POLI";"SUMOylation of DNA damage response and repair proteins";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Activation of the pre-replicative complex";"Presynaptic phase of homologous DNA pairing and strand exchange";"Translesion Synthesis by POLH";"HDR through Single Strand Annealing (SSA)";"Dual incision in TC-NER";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate from the C-strand";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion synthesis by POLK";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"PCNA-Dependent Long Patch Base Excision Repair";"HSF1 activation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Meiotic recombination";"Regulation of HSF1-mediated heat shock response"
APLA008244-PA	6	MetaCyc: PWY-6124;Reactome: R-HSA-73817;MetaCyc: PWY-6123;KEGG: 00230+3.5.4.10+2.1.2.3;MetaCyc: PWY-7234;KEGG: 00670+2.1.2.3	"Inosine-5'-phosphate biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Inosine-5'-phosphate biosynthesis III";"One carbon pool by folate"
APLA002792-PA	4	Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism"
APLA004171-PA	6	Reactome: R-HSA-9615017;Reactome: R-HSA-6798695;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6	"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Neutrophil degranulation";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism"
APLA008704-PA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
APLA012686-PA	14	MetaCyc: PWY-7411;MetaCyc: PWY-5667;MetaCyc: PWY-8055;MetaCyc: PWY-7417;MetaCyc: PWY-7782;MetaCyc: PWY-6453;MetaCyc: PWY-7589;Reactome: R-HSA-1483166;MetaCyc: PWY-8053;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5981;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-7587	"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Plasmalogen biosynthesis";"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Synthesis of PA";"Anandamide biosynthesis II";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)"
APLA009042-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA000929-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA011144-PA	5	Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-5674400;Reactome: R-HSA-1257604;Reactome: R-HSA-389357	"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"Constitutive Signaling by AKT1 E17K in Cancer";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling"
APLA015228-PA	12	Reactome: R-HSA-380270;Reactome: R-HSA-6811436;Reactome: R-HSA-381038;Reactome: R-HSA-3371497;Reactome: R-HSA-2565942;Reactome: R-HSA-2132295;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-6807878;Reactome: R-HSA-380259	"Recruitment of mitotic centrosome proteins and complexes";"COPI-independent Golgi-to-ER retrograde traffic";"XBP1(S) activates chaperone genes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Regulation of PLK1 Activity at G2/M Transition";"MHC class II antigen presentation";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"COPI-mediated anterograde transport";"Loss of Nlp from mitotic centrosomes"
APLA004528-PA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
APLA003597-PA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
APLA011610-PA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
APLA003703-PA	1	Reactome: R-HSA-1483255	"PI Metabolism"
APLA007850-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA003812-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA002083-PA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
APLA008612-PA	9	Reactome: R-HSA-69166;Reactome: R-HSA-113501;Reactome: R-HSA-69205;Reactome: R-HSA-68952;Reactome: R-HSA-68962;Reactome: R-HSA-69091;Reactome: R-HSA-174430;Reactome: R-HSA-69183;Reactome: R-HSA-174411	"Removal of the Flap Intermediate";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"G1/S-Specific Transcription";"DNA replication initiation";"Activation of the pre-replicative complex";"Polymerase switching";"Telomere C-strand synthesis initiation";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere"
APLA006345-PA	4	Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295	"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"MHC class II antigen presentation"
APLA014051-PA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
APLA000738-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA004368-PA	5	Reactome: R-HSA-110381;Reactome: R-HSA-5685939;Reactome: R-HSA-6782210;Reactome: R-HSA-5696397;Reactome: R-HSA-5649702	"Resolution of AP sites via the single-nucleotide replacement pathway";"HDR through MMEJ (alt-NHEJ)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"
APLA004850-PA	19	Reactome: R-HSA-194840;Reactome: R-HSA-5627123;Reactome: R-HSA-428543;Reactome: R-HSA-5625970;Reactome: R-HSA-5663220;Reactome: R-HSA-3928662;Reactome: R-HSA-418885;Reactome: R-HSA-389359;Reactome: R-HSA-8950505;Reactome: R-HSA-182971;Reactome: R-HSA-983231;Reactome: R-HSA-8964616;Reactome: R-HSA-2029482;Reactome: R-HSA-5626467;Reactome: R-HSA-5663213;Reactome: R-HSA-114604;Reactome: R-HSA-525793;Reactome: R-HSA-5687128;Reactome: R-HSA-4420097	"Rho GTPase cycle";"RHO GTPases activate PAKs";"Inactivation of CDC42 and RAC1";"RHO GTPases activate KTN1";"RHO GTPases Activate Formins";"EPHB-mediated forward signaling";"DCC mediated attractive signaling";"CD28 dependent Vav1 pathway";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"EGFR downregulation";"Factors involved in megakaryocyte development and platelet production";"G beta:gamma signalling through CDC42";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases activate IQGAPs";"RHO GTPases Activate WASPs and WAVEs";"GPVI-mediated activation cascade";"Myogenesis";"MAPK6/MAPK4 signaling";"VEGFA-VEGFR2 Pathway"
APLA000848-PA	3	Reactome: R-HSA-433137;Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Sodium-coupled sulphate, di- and tri-carboxylate transporters";"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
APLA008849-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA014157-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA002666-PA	8	Reactome: R-HSA-77387;KEGG: 00195+7.1.2.2;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980;Reactome: R-HSA-9639288;Reactome: R-HSA-917977	"Insulin receptor recycling";"Photosynthesis";"Ion channel transport";"ROS and RNS production in phagocytes";"Oxidative phosphorylation";"ATP biosynthesis";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling"
APLA004845-PA	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
APLA006009-PA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
APLA011535-PA	3	KEGG: 00790+6.3.2.17;Reactome: R-HSA-196757;MetaCyc: PWY-2161	"Folate biosynthesis";"Metabolism of folate and pterines";"Folate polyglutamylation"
APLA005365-PA	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
APLA006989-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA003264-PA	2	KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600	"Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
APLA011893-PA	9	Reactome: R-HSA-3560783;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096;Reactome: R-HSA-975634;Reactome: R-HSA-4420332;Reactome: R-HSA-3656253;Reactome: R-HSA-2022928;Reactome: R-HSA-1971475;Reactome: R-HSA-3560801	"Defective B4GALT7 causes EDS, progeroid type";"Defective EXT2 causes exostoses 2";"HS-GAG degradation";"Retinoid metabolism and transport";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"HS-GAG biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GAT3 causes JDSSDHD"
APLA014620-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA003691-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA009922-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA001267-PA	13	KEGG: 00240+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7220;MetaCyc: PWY-7184;MetaCyc: PWY-7222;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-7226;MetaCyc: PWY-6545;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7198;KEGG: 00480+1.17.4.1;KEGG: 00983+1.17.4.1	"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Glutathione metabolism";"Drug metabolism - other enzymes"
APLA007857-PA	31	Reactome: R-HSA-75105;MetaCyc: PWY-7746;MetaCyc: PWY-6282;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5147;MetaCyc: PWY-5366;MetaCyc: PWY-5367;MetaCyc: PWYG-321;MetaCyc: PWY-7664;MetaCyc: PWY-6799;Reactome: R-HSA-199220;MetaCyc: PWY-5989;Reactome: R-HSA-9029558;MetaCyc: PWY-7858;MetaCyc: PWY-5973;MetaCyc: PWY-5142;MetaCyc: PWY-8012;MetaCyc: PWY-7723;MetaCyc: PWY-8047;Reactome: R-HSA-2426168;MetaCyc: PWY-4381;MetaCyc: PWY-6519;MetaCyc: PWY-7388;MetaCyc: PWY-5994;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5971;MetaCyc: PWY-6113;Reactome: R-HSA-163765;MetaCyc: PWY-5966-1;MetaCyc: PWY-7663;MetaCyc: PWY-8049	"Fatty acyl-CoA biosynthesis";"Mycobacterial sulfolipid biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acid biosynthesis";"Oleate biosynthesis I (plants)";"Palmitoleate biosynthesis II (plants and bacteria)";"Petroselinate biosynthesis";"";"Oleate biosynthesis IV (anaerobic)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Vitamin B5 (pantothenate) metabolism";"Stearate biosynthesis II (bacteria and plants)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"(5Z)-dodecenoate biosynthesis II";"Cis-vaccenate biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"Mupirocin biosynthesis";"Bacterial bioluminescence";"Bryostatin biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (bacteria and plants)";"8-amino-7-oxononanoate biosynthesis I";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Biotin metabolism";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Superpathway of mycolate biosynthesis";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Gondoate biosynthesis (anaerobic)";"Pederin biosynthesis"
APLA001633-PA	22	Reactome: R-HSA-432142;Reactome: R-HSA-5358752;Reactome: R-HSA-5675221;Reactome: R-HSA-6811558;Reactome: R-HSA-4641262;Reactome: R-HSA-5358751;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-5673000;Reactome: R-HSA-5467348;Reactome: R-HSA-68877;Reactome: R-HSA-5467340;Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-389513;Reactome: R-HSA-196299;Reactome: R-HSA-141444;Reactome: R-HSA-5339716;Reactome: R-HSA-9648025;Reactome: R-HSA-195253;Reactome: R-HSA-5467337	"Platelet sensitization by LDL";"T41 mutants of beta-catenin aren't phosphorylated";"Negative regulation of MAPK pathway";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S45 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"RAF activation";"Truncations of AMER1 destabilize the destruction complex";"Mitotic Prometaphase";"AXIN missense mutants destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"CTLA4 inhibitory signaling";"Beta-catenin phosphorylation cascade";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Misspliced GSK3beta mutants stabilize beta-catenin";"EML4 and NUDC in mitotic spindle formation";"Degradation of beta-catenin by the destruction complex";"APC truncation mutants have impaired AXIN binding"
APLA001562-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA013034-PA	1	MetaCyc: PWY-6938	"NADH repair"
APLA005363-PA	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
APLA002418-PA	12	MetaCyc: PWY-5870;MetaCyc: PWY-5872;MetaCyc: PWY-5873;MetaCyc: PWY-6708;MetaCyc: PWY-5857;Reactome: R-HSA-2142789;KEGG: 00130+1.14.99.60;MetaCyc: PWY-5855;MetaCyc: PWY-5871;MetaCyc: PWY-7233;MetaCyc: PWY-5856;MetaCyc: PWY-7230	"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)"
APLA013745-PA	24	KEGG: 05165+2.7.11.1;Reactome: R-HSA-392451;Reactome: R-HSA-2871837;KEGG: 05170+2.7.11.1;Reactome: R-HSA-389357;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-354192;Reactome: R-HSA-6804757;Reactome: R-HSA-2730905;Reactome: R-HSA-165158;Reactome: R-HSA-114604;Reactome: R-HSA-5607764;Reactome: R-HSA-9634635;Reactome: R-HSA-5218921;Reactome: R-HSA-1257604;Reactome: R-HSA-444257;Reactome: R-HSA-202424;Reactome: R-HSA-5625740;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"G beta:gamma signalling through PI3Kgamma";"FCERI mediated NF-kB activation";"Human immunodeficiency virus 1 infection";"CD28 dependent PI3K/Akt signaling";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"mTOR signaling pathway";"Thermogenesis";"Integrin signaling";"Regulation of TP53 Degradation";"Role of LAT2/NTAL/LAB on calcium mobilization";"Activation of AKT2";"GPVI-mediated activation cascade";"CLEC7A (Dectin-1) signaling";"Estrogen-stimulated signaling through PRKCZ";"VEGFR2 mediated cell proliferation";"PIP3 activates AKT signaling";"RSK activation";"Downstream TCR signaling";"RHO GTPases activate PKNs";"Relaxin signaling pathway"
APLA007970-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA000660-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA003653-PA	13	Reactome: R-HSA-4086398;Reactome: R-HSA-139853;Reactome: R-HSA-2871809;Reactome: R-HSA-2029485;Reactome: R-HSA-1489509;Reactome: R-HSA-5218921;Reactome: R-HSA-422356;Reactome: R-HSA-5607763;Reactome: R-HSA-5578775;Reactome: R-HSA-112043;Reactome: R-HSA-114508;Reactome: R-HSA-381676;Reactome: R-HSA-983695	"Ca2+ pathway";"Elevation of cytosolic Ca2+ levels";"FCERI mediated Ca+2 mobilization";"Role of phospholipids in phagocytosis";"DAG and IP3 signaling";"VEGFR2 mediated cell proliferation";"Regulation of insulin secretion";"CLEC7A (Dectin-1) induces NFAT activation";"Ion homeostasis";"PLC beta mediated events";"Effects of PIP2 hydrolysis";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"
APLA002881-PA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
APLA008290-PA	9	Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-6807505;Reactome: R-HSA-167161	"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA polymerase II transcribes snRNA genes";"HIV Transcription Initiation"
APLA006113-PA	7	Reactome: R-HSA-2894862;Reactome: R-HSA-2979096;Reactome: R-HSA-9013507;Reactome: R-HSA-2660826;Reactome: R-HSA-2122948;Reactome: R-HSA-2691232;Reactome: R-HSA-2644606	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
APLA003615-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA007650-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA012202-PA	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
APLA011505-PA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
APLA004972-PA	6	KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23	"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series"
APLA002547-PA	5	Reactome: R-HSA-9029558;Reactome: R-HSA-163765;Reactome: R-HSA-75105;Reactome: R-HSA-199220;Reactome: R-HSA-2426168	"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"ChREBP activates metabolic gene expression";"Fatty acyl-CoA biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Activation of gene expression by SREBF (SREBP)"
APLA006586-PA	6	Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695	"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex"
APLA007488-PA	9	Reactome: R-HSA-70263;MetaCyc: PWY-6901;MetaCyc: PWY-5484;MetaCyc: PWY-1042;KEGG: 00010+1.2.1.12;KEGG: 00710+1.2.1.12;MetaCyc: PWY-8004;MetaCyc: PWY-7003;Reactome: R-HSA-70171	"Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Entner-Doudoroff pathway I";"Glycerol degradation to butanol";"Glycolysis"
APLA015214-PA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
APLA005175-PA	5	Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-3214815;Reactome: R-HSA-2644606	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
APLA012032-PA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
APLA011533-PA	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
APLA007143-PA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
APLA000185-PA	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
APLA008734-PA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
APLA011729-PA	2	Reactome: R-HSA-389661;Reactome: R-HSA-9033241	"Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import"
APLA007638-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA009742-PA	2	Reactome: R-HSA-2206307;Reactome: R-HSA-2024096	"MPS IIIA - Sanfilippo syndrome A";"HS-GAG degradation"
APLA002526-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA003021-PA	12	Reactome: R-HSA-3322077;MetaCyc: PWY-6527;KEGG: 00052+2.7.7.9;Reactome: R-HSA-173599;MetaCyc: PWY-3801;KEGG: 00500+2.7.7.9;KEGG: 00561+2.7.7.9;MetaCyc: PWY-7817;KEGG: 00520+2.7.7.9;KEGG: 00040+2.7.7.9;MetaCyc: PWY-7238;MetaCyc: PWY-7343	"Glycogen synthesis";"Stachyose degradation";"Galactose metabolism";"Formation of the active cofactor, UDP-glucuronate";"Sucrose degradation II (sucrose synthase)";"Starch and sucrose metabolism";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Amino sugar and nucleotide sugar metabolism";"Pentose and glucuronate interconversions";"Sucrose biosynthesis II";"UDP-alpha-D-glucose biosynthesis I"
APLA000030-PA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
APLA009692-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA000184-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA011044-PA	5	Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23;MetaCyc: PWY-5083;MetaCyc: PWY-7268;MetaCyc: PWY-7269	"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)"
APLA003270-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA001298-PA	3	KEGG: 00270+1.13.11.54;MetaCyc: PWY-4361;Reactome: R-HSA-1237112	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Methionine salvage pathway"
APLA013306-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA007487-PA	5	Reactome: R-HSA-1834941;Reactome: R-HSA-3134975;Reactome: R-HSA-3270619;Reactome: R-HSA-3249367;Reactome: R-HSA-6798695	"STING mediated induction of host immune responses";"Regulation of innate immune responses to cytosolic DNA";"IRF3-mediated induction of type I IFN";"STAT6-mediated induction of chemokines";"Neutrophil degranulation"
APLA014924-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA000577-PA	1	Reactome: R-HSA-2514859	"Inactivation, recovery and regulation of the phototransduction cascade"
APLA000059-PA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
APLA013224-PA	6	KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508	"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis"
APLA001680-PA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
APLA013702-PA	14	Reactome: R-HSA-1912408;Reactome: R-HSA-9029569;Reactome: R-HSA-5628897;Reactome: R-HSA-8934593;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-203927;Reactome: R-HSA-8943723;Reactome: R-HSA-9018519;Reactome: R-HSA-8948700;Reactome: R-HSA-426496;Reactome: R-HSA-426486;Reactome: R-HSA-8986944;Reactome: R-HSA-5687128	"Pre-NOTCH Transcription and Translation";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"TP53 Regulates Metabolic Genes";"Regulation of RUNX1 Expression and Activity";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"MicroRNA (miRNA) biogenesis";"Regulation of PTEN mRNA translation";"Estrogen-dependent gene expression";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Post-transcriptional silencing by small RNAs";"Small interfering RNA (siRNA) biogenesis";"Transcriptional Regulation by MECP2";"MAPK6/MAPK4 signaling"
APLA003986-PA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
APLA006567-PA	2	Reactome: R-HSA-71240;KEGG: 00380+1.13.11.11	"Tryptophan catabolism";"Tryptophan metabolism"
APLA003286-PA	6	Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72695	"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex"
APLA009824-PA	4	Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942	"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)"
APLA008803-PA	2	MetaCyc: PWY-7799;MetaCyc: PWY-7800	"Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway"
APLA012476-PA	3	Reactome: R-HSA-1614603;Reactome: R-HSA-2408508;Reactome: R-HSA-1614558	"Cysteine formation from homocysteine";"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Degradation of cysteine and homocysteine"
APLA005591-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA005797-PA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
APLA013820-PA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
APLA002584-PA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
APLA000465-PA	4	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA002552-PA	2	Reactome: R-HSA-8873719;Reactome: R-HSA-6803205	"RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"
APLA014473-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA001125-PA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
APLA002256-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA015229-PA	4	Reactome: R-HSA-163210;Reactome: R-HSA-611105;Reactome: R-HSA-6799198;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Respiratory electron transport";"Complex I biogenesis";"Cristae formation"
APLA004385-PA	4	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
APLA008907-PA	1	Reactome: R-HSA-71384	"Ethanol oxidation"
APLA014431-PA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
APLA006848-PA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
APLA009527-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA003001-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA006555-PA	2	Reactome: R-HSA-72702;Reactome: R-HSA-72706	"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit"
APLA003149-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA004124-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA013670-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA007030-PA	19	Reactome: R-HSA-5576892;Reactome: R-HSA-442982;Reactome: R-HSA-936837;Reactome: R-HSA-3371571;Reactome: R-HSA-9620244;Reactome: R-HSA-9617324;Reactome: R-HSA-6802952;Reactome: R-HSA-5673001;Reactome: R-HSA-6802946;Reactome: R-HSA-399719;Reactome: R-HSA-9609736;Reactome: R-HSA-9649948;Reactome: R-HSA-438066;Reactome: R-HSA-5673000;Reactome: R-HSA-5578775;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-877300;Reactome: R-HSA-6802955	"Phase 0 - rapid depolarisation";"Ras activation upon Ca2+ influx through NMDA receptor";"Ion transport by P-type ATPases";"HSF1-dependent transactivation";"Long-term potentiation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by BRAF and RAF fusions";"RAF/MAP kinase cascade";"Signaling by moderate kinase activity BRAF mutants";"Trafficking of AMPA receptors";"Assembly and cell surface presentation of NMDA receptors";"Signaling downstream of RAS mutants";"Unblocking of NMDA receptors, glutamate binding and activation";"RAF activation";"Ion homeostasis";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Interferon gamma signaling";"Paradoxical activation of RAF signaling by kinase inactive BRAF"
APLA004887-PA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
APLA000369-PA	3	MetaCyc: PWY-6689;Reactome: R-HSA-6784531;MetaCyc: PWY-7803	"Trna splicing I";"tRNA processing in the nucleus";"Trna splicing II"
APLA013591-PA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
APLA004323-PA	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-2565942	"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition"
APLA009112-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA008824-PA	3	Reactome: R-HSA-204174;Reactome: R-HSA-156590;Reactome: R-HSA-8963684	"Regulation of pyruvate dehydrogenase (PDH) complex";"Glutathione conjugation";"Tyrosine catabolism"
APLA014953-PA	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
APLA012224-PA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
APLA010640-PA	2	Reactome: R-HSA-5673001;Reactome: R-HSA-8853659	"RAF/MAP kinase cascade";"RET signaling"
APLA010662-PA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA014038-PA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
APLA003082-PA	13	Reactome: R-HSA-2243919;Reactome: R-HSA-1474244;Reactome: R-HSA-3000157;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-2022090;Reactome: R-HSA-419037;Reactome: R-HSA-1650814;Reactome: R-HSA-186797;Reactome: R-HSA-2214320;Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-216083	"Crosslinking of collagen fibrils";"Extracellular matrix organization";"Laminin interactions";"Collagen chain trimerization";"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures";"NCAM1 interactions";"Collagen biosynthesis and modifying enzymes";"Signaling by PDGF";"Anchoring fibril formation";"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Integrin cell surface interactions"
APLA007021-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA002575-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA000684-PA	19	Reactome: R-HSA-70263;MetaCyc: PWY-6969;MetaCyc: PWY-7383;MetaCyc: PWY-561;MetaCyc: PWY-7115;MetaCyc: PWY-6728;Reactome: R-HSA-71403;KEGG: 00710+1.1.1.37;MetaCyc: PWY-5913;KEGG: 00720+1.1.1.37;MetaCyc: PWY-1622;MetaCyc: PWY-5392;MetaCyc: PWY-5690;MetaCyc: PWY-8086;KEGG: 00630+1.1.1.37;KEGG: 00680+1.1.1.37;KEGG: 00620+1.1.1.37;KEGG: 00020+1.1.1.37;KEGG: 00270+1.1.1.37	"Gluconeogenesis";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Superpathway of glyoxylate cycle and fatty acid degradation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Carbon fixation in photosynthetic organisms";"Partial TCA cycle (obligate autotrophs)";"Carbon fixation pathways in prokaryotes";"Formaldehyde assimilation I (serine pathway)";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Glyoxylate and dicarboxylate metabolism";"Methane metabolism";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Cysteine and methionine metabolism"
APLA009647-PA	1	Reactome: R-HSA-6804756	"Regulation of TP53 Activity through Phosphorylation"
APLA014241-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA003896-PA	10	Reactome: R-HSA-916853;MetaCyc: PWY-5022;MetaCyc: PWY-6537;KEGG: 00640+2.6.1.19;MetaCyc: PWY-4321;MetaCyc: PWY-6536;KEGG: 00650+2.6.1.19;MetaCyc: PWY-6535;KEGG: 00250+2.6.1.19;KEGG: 00410+2.6.1.19	"Degradation of GABA";"4-aminobutanoate degradation V";"4-aminobutanoate degradation II";"Propanoate metabolism";"L-glutamate degradation IV";"4-aminobutanoate degradation III";"Butanoate metabolism";"4-aminobutanoate degradation I";"Alanine, aspartate and glutamate metabolism";"beta-Alanine metabolism"
APLA011453-PA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
APLA015473-PA	1	Reactome: R-HSA-5689603	"UCH proteinases"
APLA000832-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA013005-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA006184-PA	3	Reactome: R-HSA-1483191;Reactome: R-HSA-422085;Reactome: R-HSA-112311	"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin";"Neurotransmitter clearance"
APLA004739-PA	4	Reactome: R-HSA-1614558;KEGG: 00430+1.13.11.20;MetaCyc: PWY-5331;KEGG: 00270+1.13.11.20	"Degradation of cysteine and homocysteine";"Taurine and hypotaurine metabolism";"Taurine biosynthesis I";"Cysteine and methionine metabolism"
APLA014062-PA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
APLA005756-PA	56	Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-450408;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5678895;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-195253	"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Separation of Sister Chromatids";"Neddylation";"Defective CFTR causes cystic fibrosis";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex"
APLA003070-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA008439-PA	4	Reactome: R-HSA-73614;MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48;KEGG: 00983+2.7.1.48	"Pyrimidine salvage";"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism";"Drug metabolism - other enzymes"
APLA002625-PA	16	Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649	"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation"
APLA008422-PA	3	MetaCyc: PWY-6367;MetaCyc: PWY-6368;KEGG: 04070+3.1.3.78	"D-myo-inositol-5-phosphate metabolism";"3-phosphoinositide degradation";"Phosphatidylinositol signaling system"
APLA004097-PA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
APLA004324-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA006015-PA	5	Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Ion channel transport"
APLA000878-PA	1	MetaCyc: PWY-7533	"Gliotoxin biosynthesis"
APLA005796-PA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
APLA010039-PA	4	Reactome: R-HSA-2029482;Reactome: R-HSA-8856828;Reactome: R-HSA-5663213;Reactome: R-HSA-3928662	"Regulation of actin dynamics for phagocytic cup formation";"Clathrin-mediated endocytosis";"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling"
APLA005101-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA007407-PA	6	Reactome: R-HSA-194840;KEGG: 00562+3.1.3.36;Reactome: R-HSA-1855183;MetaCyc: PWY-6368;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1855204	"Rho GTPase cycle";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"3-phosphoinositide degradation";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol"
APLA007969-PA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
APLA013647-PA	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
APLA007436-PA	4	Reactome: R-HSA-8964539;KEGG: 00330+1.2.1.41;KEGG: 00332+1.2.1.41;MetaCyc: PWY-6922	"Glutamate and glutamine metabolism";"Arginine and proline metabolism";"Carbapenem biosynthesis";"L-Ndelta-acetylornithine biosynthesis"
APLA011959-PA	5	Reactome: R-HSA-75035;Reactome: R-HSA-5625740;Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-5628897	"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"TP53 Regulates Metabolic Genes"
APLA013300-PA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
APLA002004-PA	2	Reactome: R-HSA-9010553;Reactome: R-HSA-975957	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA000289-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
APLA014464-PA	1	Reactome: R-HSA-1483101	"Synthesis of PS"
APLA000198-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA010316-PA	1	Reactome: R-HSA-8953750	"Transcriptional Regulation by E2F6"
APLA011745-PA	4	KEGG: 00970+6.1.1.17;MetaCyc: PWY-5188;KEGG: 00860+6.1.1.17;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"Mitochondrial tRNA aminoacylation"
APLA000866-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA008936-PA	7	MetaCyc: PWY-7282;MetaCyc: PWY-6121;Reactome: R-HSA-73817;MetaCyc: PWY-6122;MetaCyc: PWY-6277;KEGG: 00230+2.4.2.14;KEGG: 00250+2.4.2.14	"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine metabolism";"Alanine, aspartate and glutamate metabolism"
APLA014577-PA	13	Reactome: R-HSA-196836;KEGG: 00982+2.5.1.18;Reactome: R-HSA-156590;MetaCyc: PWY-6370;KEGG: 00480+2.5.1.18+1.8.5.1;KEGG: 00980+2.5.1.18;MetaCyc: PWY-7533;MetaCyc: PWY-2261;KEGG: 00983+2.5.1.18;KEGG: 00053+1.8.5.1;MetaCyc: PWY-4061;MetaCyc: PWY-7112;MetaCyc: PWY-6842	"Vitamin C (ascorbate) metabolism";"Drug metabolism - cytochrome P450";"Glutathione conjugation";"Ascorbate recycling (cytosolic)";"Glutathione metabolism";"Metabolism of xenobiotics by cytochrome P450";"Gliotoxin biosynthesis";"Ascorbate glutathione cycle";"Drug metabolism - other enzymes";"Ascorbate and aldarate metabolism";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification II"
APLA009721-PA	4	Reactome: R-HSA-3000178;Reactome: R-HSA-216083;Reactome: R-HSA-2129379;Reactome: R-HSA-3000170	"ECM proteoglycans";"Integrin cell surface interactions";"Molecules associated with elastic fibres";"Syndecan interactions"
APLA005405-PA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-202427;Reactome: R-HSA-6807004	"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity"
APLA008549-PA	3	MetaCyc: PWY-7807;KEGG: 00190+3.6.1.1;MetaCyc: PWY-7805	"Glyphosate degradation III";"Oxidative phosphorylation";"(aminomethyl)phosphonate degradation"
APLA014136-PA	5	Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-73772	"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape"
APLA007417-PA	11	Reactome: R-HSA-432040;Reactome: R-HSA-418597;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-164378;Reactome: R-HSA-170660	"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"Hedgehog 'off' state";"PKA activation";"G alpha (i) signalling events";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation in glucagon signalling";"Adenylate cyclase activating pathway"
APLA008675-PA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
APLA007172-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA004889-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA003816-PA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
APLA001209-PA	1	Reactome: R-HSA-191859	"snRNP Assembly"
APLA005867-PA	1	Reactome: R-HSA-71262	"Carnitine synthesis"
APLA015388-PA	16	Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane"
APLA007986-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA007938-PA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-164843;Reactome: R-HSA-1834949;Reactome: R-HSA-3270619;Reactome: R-HSA-5693571	"Neutrophil degranulation";"2-LTR circle formation";"Cytosolic sensors of pathogen-associated DNA";"IRF3-mediated induction of type I IFN";"Nonhomologous End-Joining (NHEJ)"
APLA001529-PA	3	MetaCyc: PWY-4361;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism"
APLA002583-PA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
APLA011732-PA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
APLA002282-PA	11	MetaCyc: PWY-6608;MetaCyc: PWY-7185;KEGG: 00230+3.1.3.5;MetaCyc: PWY-6607;MetaCyc: PWY-6596;MetaCyc: PWY-7821;KEGG: 00760+3.1.3.5;MetaCyc: PWY-6606;KEGG: 00240+3.1.3.5;MetaCyc: PWY-5381;MetaCyc: PWY-5695	"Guanosine nucleotides degradation III";"UTP and CTP dephosphorylation I";"Purine metabolism";"Guanosine nucleotides degradation I";"Adenosine nucleotides degradation I";"Tunicamycin biosynthesis";"Nicotinate and nicotinamide metabolism";"Guanosine nucleotides degradation II";"Pyrimidine metabolism";"Pyridine nucleotide cycling (plants)";"Inosine 5'-phosphate degradation"
APLA005907-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA004000-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
APLA009858-PA	2	Reactome: R-HSA-456926;Reactome: R-HSA-416482	"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (12/13) signalling events"
APLA004194-PA	4	Reactome: R-HSA-4655427;Reactome: R-HSA-5334118;Reactome: R-HSA-212300;KEGG: 00270+2.1.1.37	"SUMOylation of DNA methylation proteins";"DNA methylation";"PRC2 methylates histones and DNA";"Cysteine and methionine metabolism"
APLA009107-PA	3	Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation"
APLA005368-PA	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
APLA005141-PA	29	Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-110312;Reactome: R-HSA-68962;Reactome: R-HSA-5693616;Reactome: R-HSA-5358606;Reactome: R-HSA-3108214;Reactome: R-HSA-5685938;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-6782210;Reactome: R-HSA-69166;Reactome: R-HSA-5656121;Reactome: R-HSA-6783310;Reactome: R-HSA-5696395;Reactome: R-HSA-176187;Reactome: R-HSA-5651801;Reactome: R-HSA-5693607;Reactome: R-HSA-110314;Reactome: R-HSA-174437;Reactome: R-HSA-5685942;Reactome: R-HSA-5358565;Reactome: R-HSA-5655862;Reactome: R-HSA-912446;Reactome: R-HSA-3371453;Reactome: R-HSA-5696397;Reactome: R-HSA-3371511	"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Translesion synthesis by REV1";"Activation of the pre-replicative complex";"Presynaptic phase of homologous DNA pairing and strand exchange";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"SUMOylation of DNA damage response and repair proteins";"HDR through Single Strand Annealing (SSA)";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Removal of the Flap Intermediate";"Translesion synthesis by POLI";"Fanconi Anemia Pathway";"Formation of Incision Complex in GG-NER";"Activation of ATR in response to replication stress";"PCNA-Dependent Long Patch Base Excision Repair";"Processing of DNA double-strand break ends";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate from the C-strand";"HDR through Homologous Recombination (HRR)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion synthesis by POLK";"Meiotic recombination";"Regulation of HSF1-mediated heat shock response";"Gap-filling DNA repair synthesis and ligation in GG-NER";"HSF1 activation"
APLA001944-PA	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
APLA002186-PA	3	Reactome: R-HSA-6807004;Reactome: R-HSA-202427;Reactome: R-HSA-6798695	"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation"
APLA002231-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA002129-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA004063-PA	1	Reactome: R-HSA-419771	"Opsins"
APLA010633-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA001570-PA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
APLA004448-PA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
APLA004307-PA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
APLA011894-PA	9	Reactome: R-HSA-975634;Reactome: R-HSA-4420332;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096;Reactome: R-HSA-3560783;Reactome: R-HSA-3560801;Reactome: R-HSA-1971475;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253	"Retinoid metabolism and transport";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT2 causes exostoses 2";"HS-GAG degradation";"Defective B4GALT7 causes EDS, progeroid type";"Defective B3GAT3 causes JDSSDHD";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS"
APLA010064-PA	14	MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5080	"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I"
APLA015384-PA	5	Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-72163;Reactome: R-HSA-6782135	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"mRNA Splicing - Major Pathway";"Dual incision in TC-NER"
APLA005504-PA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
APLA005404-PA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
APLA008085-PA	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
APLA004285-PA	10	MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-7559;MetaCyc: PWY-4061;MetaCyc: PWY-7112;KEGG: 00460+2.3.2.2;MetaCyc: PWY-6842;MetaCyc: PWY-4041;MetaCyc: PWY-5826	"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Glutathione metabolism";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Cyanoamino acid metabolism";"Glutathione-mediated detoxification II";"Gamma-glutamyl cycle";"Hypoglycin biosynthesis"
APLA011061-PA	6	Reactome: R-HSA-9615017;MetaCyc: PWY-6854;Reactome: R-HSA-2151201;Reactome: R-HSA-3299685;Reactome: R-HSA-8862803;Reactome: R-HSA-8950505	"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Ethylene biosynthesis III (microbes)";"Transcriptional activation of mitochondrial biogenesis";"Detoxification of Reactive Oxygen Species";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
APLA012810-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA012579-PA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA001114-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA005999-PA	6	Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72702	"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition"
APLA013074-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA008283-PA	11	Reactome: R-HSA-6782210;Reactome: R-HSA-5696397;Reactome: R-HSA-68962;Reactome: R-HSA-68952;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-174430;Reactome: R-HSA-5696400;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Activation of the pre-replicative complex";"DNA replication initiation";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"Telomere C-strand synthesis initiation";"Dual Incision in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis"
APLA007550-PA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.7	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
APLA013383-PA	5	Reactome: R-HSA-3214815;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947	"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
APLA010013-PA	13	Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72689	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits"
APLA004075-PA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-9010553	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs"
APLA013787-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA004126-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA005265-PA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72706	"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit"
APLA009708-PA	27	Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-5619107;Reactome: R-HSA-170822;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-3301854;Reactome: R-HSA-4570464;Reactome: R-HSA-159230;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-4551638;Reactome: R-HSA-159231;Reactome: R-HSA-9610379;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-6784531;Reactome: R-HSA-159227;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-4085377	"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of RNA binding proteins";"Transport of the SLBP Dependant Mature mRNA";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Late Events";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"tRNA processing in the nucleus";"Transport of the SLBP independent Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"SUMOylation of SUMOylation proteins"
APLA013357-PA	26	Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-6811434;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-8852276;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-437239;Reactome: R-HSA-389977;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-389960;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-380320;Reactome: R-HSA-2132295;Reactome: R-HSA-190840;Reactome: R-HSA-5617833;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-983189	"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-dependent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Post-chaperonin tubulin folding pathway";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Formation of tubulin folding intermediates by CCT/TriC";"Gap junction assembly";"HCMV Early Events";"Recruitment of NuMA to mitotic centrosomes";"MHC class II antigen presentation";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Cilium Assembly";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Kinesins"
APLA015026-PA	2	Reactome: R-HSA-194840;Reactome: R-HSA-8876198	"Rho GTPase cycle";"RAB GEFs exchange GTP for GDP on RABs"
APLA010605-PA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156902	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation"
APLA010140-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA004907-PA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-8953750	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Transcriptional Regulation by E2F6"
APLA005745-PA	1	Reactome: R-HSA-1855231	"Synthesis of IPs in the ER lumen"
APLA004282-PA	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
APLA009944-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA001457-PA	7	Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-1538133;Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-156711	"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"G0 and Early G1";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Polo-like kinase mediated events"
APLA012812-PA	1	Reactome: R-HSA-2465910	"MASTL Facilitates Mitotic Progression"
APLA010999-PA	13	Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72689	"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits"
APLA009142-PA	10	MetaCyc: PWY-7187;Reactome: R-HSA-69205;KEGG: 00240+2.1.1.45;MetaCyc: PWY-7198;Reactome: R-HSA-499943;MetaCyc: PWY-7210;MetaCyc: PWY-7184;MetaCyc: PWY-3841;MetaCyc: PWY-7199;KEGG: 00670+2.1.1.45	"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"G1/S-Specific Transcription";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Folate transformations II (plants)";"Pyrimidine deoxyribonucleosides salvage";"One carbon pool by folate"
APLA002140-PA	44	Reactome: R-HSA-6811558;Reactome: R-HSA-3371453;Reactome: R-HSA-5654732;Reactome: R-HSA-881907;Reactome: R-HSA-8943724;Reactome: R-HSA-74749;Reactome: R-HSA-445144;Reactome: R-HSA-202670;Reactome: R-HSA-170968;Reactome: R-HSA-5673001;Reactome: R-HSA-5654727;Reactome: R-HSA-162658;Reactome: R-HSA-198753;Reactome: R-HSA-6802948;Reactome: R-HSA-1295596;Reactome: R-HSA-5654726;Reactome: R-HSA-444257;Reactome: R-HSA-8940973;Reactome: R-HSA-5663213;Reactome: R-HSA-456926;Reactome: R-HSA-879415;Reactome: R-HSA-2029482;Reactome: R-HSA-5674135;Reactome: R-HSA-2871796;Reactome: R-HSA-982772;Reactome: R-HSA-8939211;Reactome: R-HSA-5675221;Reactome: R-HSA-5654733;Reactome: R-HSA-6802952;Reactome: R-HSA-2559580;Reactome: R-HSA-5668599;Reactome: R-HSA-6802946;Reactome: R-HSA-5674499;Reactome: R-HSA-9649948;Reactome: R-HSA-2559585;Reactome: R-HSA-450341;Reactome: R-HSA-9635465;KEGG: 04150+2.7.11.24;Reactome: R-HSA-9627069;Reactome: R-HSA-112409;Reactome: R-HSA-9634638;Reactome: R-HSA-6802955;Reactome: R-HSA-2559582;Reactome: R-HSA-375165	"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Regulation of HSF1-mediated heat shock response";"Negative regulation of FGFR3 signaling";"Gastrin-CREB signalling pathway via PKC and MAPK";"Regulation of PTEN gene transcription";"Signal attenuation";"Signal transduction by L1";"ERKs are inactivated";"Frs2-mediated activation";"RAF/MAP kinase cascade";"Negative regulation of FGFR2 signaling";"Golgi Cisternae Pericentriolar Stack Reorganization";"ERK/MAPK targets";"Signaling by high-kinase activity BRAF mutants";"Spry regulation of FGF signaling";"Negative regulation of FGFR1 signaling";"RSK activation";"RUNX2 regulates osteoblast differentiation";"RHO GTPases Activate WASPs and WAVEs";"Thrombin signalling through proteinase activated receptors (PARs)";"Advanced glycosylation endproduct receptor signaling";"Regulation of actin dynamics for phagocytic cup formation";"MAP2K and MAPK activation";"FCERI mediated MAPK activation";"Growth hormone receptor signaling";"ESR-mediated signaling";"Negative regulation of MAPK pathway";"Negative regulation of FGFR4 signaling";"Signaling by BRAF and RAF fusions";"Oxidative Stress Induced Senescence";"RHO GTPases Activate NADPH Oxidases";"Signaling by moderate kinase activity BRAF mutants";"Negative feedback regulation of MAPK pathway";"Signaling downstream of RAS mutants";"Oncogene Induced Senescence";"Activation of the AP-1 family of transcription factors";"Suppression of apoptosis";"mTOR signaling pathway";"Regulation of the apoptosome activity";"RAF-independent MAPK1/3 activation";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Senescence-Associated Secretory Phenotype (SASP)";"NCAM signaling for neurite out-growth"
APLA001203-PA	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
APLA015291-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA004634-PA	3	Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837	"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases"
APLA010572-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA011624-PA	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
APLA002336-PA	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
APLA003014-PA	13	Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-9633012	"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
APLA001150-PA	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
APLA000853-PA	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
APLA005706-PA	16	Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane"
APLA002127-PA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
APLA003605-PA	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
APLA001679-PA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA003620-PA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
APLA013862-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA010175-PA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
APLA004463-PA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-5689880	"Mitochondrial calcium ion transport";"Ub-specific processing proteases"
APLA000012-PA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
APLA005086-PA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
APLA001556-PA	4	Reactome: R-HSA-9020702;Reactome: R-HSA-975144;MetaCyc: PWY-7511;Reactome: R-HSA-937039	"Interleukin-1 signaling";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Protein ubiquitination";"IRAK1 recruits IKK complex"
APLA007967-PA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
APLA003193-PA	28	Reactome: R-HSA-6804756;Reactome: R-HSA-5656169;Reactome: R-HSA-69473;Reactome: R-HSA-5696400;Reactome: R-HSA-110312;Reactome: R-HSA-5693616;Reactome: R-HSA-68962;Reactome: R-HSA-5358606;Reactome: R-HSA-6782135;Reactome: R-HSA-5685938;Reactome: R-HSA-110320;Reactome: R-HSA-6782210;Reactome: R-HSA-69166;Reactome: R-HSA-5656121;Reactome: R-HSA-6783310;Reactome: R-HSA-5696395;Reactome: R-HSA-5651801;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-174437;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-5655862;Reactome: R-HSA-5358565;Reactome: R-HSA-912446;Reactome: R-HSA-3371453;Reactome: R-HSA-5696397;Reactome: R-HSA-3371511	"Regulation of TP53 Activity through Phosphorylation";"Termination of translesion DNA synthesis";"G2/M DNA damage checkpoint";"Dual Incision in GG-NER";"Translesion synthesis by REV1";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of the pre-replicative complex";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Dual incision in TC-NER";"HDR through Single Strand Annealing (SSA)";"Translesion Synthesis by POLH";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Removal of the Flap Intermediate";"Translesion synthesis by POLI";"Fanconi Anemia Pathway";"Formation of Incision Complex in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"Removal of the Flap Intermediate from the C-strand";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by POLK";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Meiotic recombination";"Regulation of HSF1-mediated heat shock response";"Gap-filling DNA repair synthesis and ligation in GG-NER";"HSF1 activation"
APLA015273-PA	4	Reactome: R-HSA-166058;Reactome: R-HSA-975138;Reactome: R-HSA-6799198;Reactome: R-HSA-975871	"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"Complex I biogenesis";"MyD88 cascade initiated on plasma membrane"
APLA010332-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA008613-PA	6	Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-176974	"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA"
APLA012795-PA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
APLA000704-PA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733	"Wax biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis"
APLA003999-PA	1	Reactome: R-HSA-191859	"snRNP Assembly"
APLA004561-PA	3	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
APLA009884-PA	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
APLA003509-PA	18	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-166208;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-6790901;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"mTORC1-mediated signalling";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
APLA001775-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA008078-PA	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
APLA011145-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA008047-PA	4	MetaCyc: PWY-6803;KEGG: 00564+3.1.1.32;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32	"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism"
APLA012176-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA002444-PA	27	Reactome: R-HSA-3301854;Reactome: R-HSA-4570464;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-5619107;Reactome: R-HSA-170822;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-3232142;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-168333;Reactome: R-HSA-5578749	"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of RNA binding proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"SUMOylation of ubiquitinylation proteins";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transcriptional regulation by small RNAs"
APLA000140-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA010585-PA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
APLA011969-PA	4	MetaCyc: PWY-5737;MetaCyc: PWY-6922;Reactome: R-HSA-70688;KEGG: 00330+1.5.5.2	"(5R)-carbapenem carboxylate biosynthesis";"L-Ndelta-acetylornithine biosynthesis";"Proline catabolism";"Arginine and proline metabolism"
APLA007753-PA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
APLA013237-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA005906-PA	5	Reactome: R-HSA-4655427;Reactome: R-HSA-427413;Reactome: R-HSA-5334118;Reactome: R-HSA-212300;KEGG: 00270+2.1.1.37	"SUMOylation of DNA methylation proteins";"NoRC negatively regulates rRNA expression";"DNA methylation";"PRC2 methylates histones and DNA";"Cysteine and methionine metabolism"
APLA015489-PA	14	KEGG: 00650+1.3.5.1;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-7279;MetaCyc: PWY-561;MetaCyc: PWY-4302;Reactome: R-HSA-611105;MetaCyc: PWY-7254;KEGG: 00020+1.3.5.1;MetaCyc: PWY-5690;KEGG: 00720+1.3.5.1;MetaCyc: PWY-6969;KEGG: 00190+1.3.5.1;MetaCyc: PWY-3781	"Butanoate metabolism";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Aerobic respiration II (cytochrome c) (yeast)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration III (alternative oxidase pathway)";"Respiratory electron transport";"TCA cycle VII (acetate-producers)";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Oxidative phosphorylation";"Aerobic respiration I (cytochrome c)"
APLA014335-PA	2	Reactome: R-HSA-8950505;Reactome: R-HSA-1237112	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Methionine salvage pathway"
APLA000884-PA	20	Reactome: R-HSA-6804756;Reactome: R-HSA-5696400;Reactome: R-HSA-69473;Reactome: R-HSA-5656169;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-5656121;Reactome: R-HSA-5693616;Reactome: R-HSA-69091;Reactome: R-HSA-110320;Reactome: R-HSA-5685938;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-5655862;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-5651801;Reactome: R-HSA-5696397	"Regulation of TP53 Activity through Phosphorylation";"Dual Incision in GG-NER";"G2/M DNA damage checkpoint";"Termination of translesion DNA synthesis";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by POLI";"Presynaptic phase of homologous DNA pairing and strand exchange";"Polymerase switching";"Translesion Synthesis by POLH";"HDR through Single Strand Annealing (SSA)";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by POLK";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"PCNA-Dependent Long Patch Base Excision Repair";"Gap-filling DNA repair synthesis and ligation in GG-NER"
APLA007166-PA	10	KEGG: 00280+2.3.3.10;KEGG: 00072+2.3.3.10;Reactome: R-HSA-1989781;MetaCyc: PWY-7524;MetaCyc: PWY-7391;KEGG: 00650+2.3.3.10;MetaCyc: PWY-6174;MetaCyc: PWY-7571;KEGG: 00900+2.3.3.10;MetaCyc: PWY-922	"Valine, leucine and isoleucine degradation";"Synthesis and degradation of ketone bodies";"PPARA activates gene expression";"Mevalonate pathway III (archaea)";"Isoprene biosynthesis II (engineered)";"Butanoate metabolism";"Mevalonate pathway II (archaea)";"Ferrichrome A biosynthesis";"Terpenoid backbone biosynthesis";"Mevalonate pathway I"
APLA012635-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
APLA006751-PA	5	KEGG: 00230+2.7.4.3;KEGG: 00230+2.7.4.10;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219;Reactome: R-HSA-499943	"Purine metabolism";"Purine metabolism";"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates"
APLA005019-PA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
APLA014137-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA008446-PA	26	Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-983189;Reactome: R-HSA-389960;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-5617833;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-68877;Reactome: R-HSA-9619483;Reactome: R-HSA-380320;Reactome: R-HSA-2132295;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-389977;Reactome: R-HSA-6811434;Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-8955332	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Kinesins";"Formation of tubulin folding intermediates by CCT/TriC";"Gap junction assembly";"HCMV Early Events";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Cilium Assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Mitotic Prometaphase";"Activation of AMPK downstream of NMDARs";"Recruitment of NuMA to mitotic centrosomes";"MHC class II antigen presentation";"Aggrephagy";"Separation of Sister Chromatids";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"Post-chaperonin tubulin folding pathway";"COPI-dependent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Carboxyterminal post-translational modifications of tubulin"
APLA002525-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA014040-PA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
APLA009810-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA007020-PA	5	KEGG: 00520+2.6.1.16;Reactome: R-HSA-446210;MetaCyc: PWY-6749;KEGG: 00250+2.6.1.16;MetaCyc: PWY-8013	"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"CMP-legionaminate biosynthesis I";"Alanine, aspartate and glutamate metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis III"
APLA010171-PA	2	Reactome: R-HSA-72764;Reactome: R-HSA-156581	"Eukaryotic Translation Termination";"Methylation"
APLA008732-PA	7	Reactome: R-HSA-166208;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852	"mTORC1-mediated signalling";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"mTOR signalling";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy"
APLA005397-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA013964-PA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
APLA007847-PA	4	KEGG: 00250+6.3.4.4;Reactome: R-HSA-73817;MetaCyc: PWY-7219;KEGG: 00230+6.3.4.4	"Alanine, aspartate and glutamate metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism"
APLA014538-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA003690-PA	11	KEGG: 04926+2.7.11.1;Reactome: R-HSA-2559580;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-450302;KEGG: 05170+2.7.11.1;Reactome: R-HSA-4420097;Reactome: R-HSA-171007;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Oxidative Stress Induced Senescence";"mTOR signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"activated TAK1 mediates p38 MAPK activation";"Human immunodeficiency virus 1 infection";"VEGFA-VEGFR2 Pathway";"p38MAPK events";"Human papillomavirus infection"
APLA009814-PA	6	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5675221;KEGG: 04660+3.1.3.16;Reactome: R-HSA-5693565;Reactome: R-HSA-8939211	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"Negative regulation of MAPK pathway";"T cell receptor signaling pathway";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"ESR-mediated signaling"
APLA001710-PA	1	Reactome: R-HSA-525793	"Myogenesis"
APLA002420-PA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
APLA004988-PA	1	Reactome: R-HSA-446193	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
APLA011831-PA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
APLA009342-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA003502-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA003353-PA	11	Reactome: R-HSA-5693616;Reactome: R-HSA-5685938;Reactome: R-HSA-69166;Reactome: R-HSA-5693554;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-174437;Reactome: R-HSA-5693579	"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Single Strand Annealing (SSA)";"Removal of the Flap Intermediate";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Removal of the Flap Intermediate from the C-strand";"Homologous DNA Pairing and Strand Exchange"
APLA014159-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA000963-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA001035-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA004140-PA	5	Reactome: R-HSA-166208;Reactome: R-HSA-165159;Reactome: R-HSA-5674400;Reactome: R-HSA-198323;Reactome: R-HSA-3371571	"mTORC1-mediated signalling";"mTOR signalling";"Constitutive Signaling by AKT1 E17K in Cancer";"AKT phosphorylates targets in the cytosol";"HSF1-dependent transactivation"
APLA010381-PA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
APLA015091-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA014830-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA011113-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA003487-PA	5	MetaCyc: PWY-6891;KEGG: 00900+2.2.1.7;KEGG: 00730+2.2.1.7;MetaCyc: PWY-7560;MetaCyc: PWY-6892	"Thiazole biosynthesis II (aerobic bacteria)";"Terpenoid backbone biosynthesis";"Thiamine metabolism";"Methylerythritol phosphate pathway II";"Thiazole biosynthesis I (facultative anaerobic bacteria)"
APLA005031-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA007609-PA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
APLA011862-PA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
APLA010173-PA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
APLA010583-PA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
APLA010645-PA	5	MetaCyc: PWY-5189;Reactome: R-HSA-189451;KEGG: 00260+2.3.1.37;MetaCyc: PWY-7536;KEGG: 00860+2.3.1.37	"Tetrapyrrole biosynthesis II (from glycine)";"Heme biosynthesis";"Glycine, serine and threonine metabolism";"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Porphyrin and chlorophyll metabolism"
APLA010287-PA	3	Reactome: R-HSA-1660517;Reactome: R-HSA-1660514;Reactome: R-HSA-1660516	"Synthesis of PIPs at the late endosome membrane";"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the early endosome membrane"
APLA012074-PA	4	Reactome: R-HSA-389661;Reactome: R-HSA-611105;Reactome: R-HSA-6799198;Reactome: R-HSA-77289	"Glyoxylate metabolism and glycine degradation";"Respiratory electron transport";"Complex I biogenesis";"Mitochondrial Fatty Acid Beta-Oxidation"
APLA009255-PA	9	Reactome: R-HSA-198323;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1	"AKT phosphorylates targets in the cytosol";"Thermogenesis";"mTOR signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection"
APLA006720-PA	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
APLA011923-PA	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
APLA003650-PA	5	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-204005;Reactome: R-HSA-6811438;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"COPII-mediated vesicle transport";"Intra-Golgi traffic";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA006380-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA009423-PA	4	Reactome: R-HSA-69205;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-176974	"G1/S-Specific Transcription";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Unwinding of DNA"
APLA000700-PA	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
APLA003784-PA	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
APLA000960-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA008067-PA	8	Reactome: R-HSA-68689;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68616;Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68949;Reactome: R-HSA-68962	"CDC6 association with the ORC:origin complex";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication";"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Orc1 removal from chromatin";"Activation of the pre-replicative complex"
APLA014355-PA	8	Reactome: R-HSA-6804115;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
APLA006577-PA	1	Reactome: R-HSA-5689896	"Ovarian tumor domain proteases"
APLA014958-PA	10	Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938;Reactome: R-HSA-3108214;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554	"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)";"SUMOylation of DNA damage response and repair proteins";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
APLA001551-PA	52	Reactome: R-HSA-76066;Reactome: R-HSA-9018519;Reactome: R-HSA-167238;Reactome: R-HSA-73762;Reactome: R-HSA-167242;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-73780;Reactome: R-HSA-6782210;Reactome: R-HSA-72165;Reactome: R-HSA-6796648;Reactome: R-HSA-73772;Reactome: R-HSA-6807505;Reactome: R-HSA-5617472;Reactome: R-HSA-749476;Reactome: R-HSA-6781827;Reactome: R-HSA-6803529;Reactome: R-HSA-167158;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-5578749;Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-72203;Reactome: R-HSA-76042;Reactome: R-HSA-5250924;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-427413;Reactome: R-HSA-76061;Reactome: R-HSA-77075;Reactome: R-HSA-75955;Reactome: R-HSA-5601884;Reactome: R-HSA-167246;Reactome: R-HSA-73980;Reactome: R-HSA-6782135;Reactome: R-HSA-112382;Reactome: R-HSA-167160;Reactome: R-HSA-203927;Reactome: R-HSA-72163;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-8851708;Reactome: R-HSA-167290	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Estrogen-dependent gene expression";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase I Transcription Initiation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Chain Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Minor Pathway";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Promoter Escape";"RNA polymerase II transcribes snRNA genes";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase III Abortive And Retractive Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"FGFR2 alternative splicing";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"Transcriptional regulation by small RNAs";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"mRNA Capping";"Formation of the Early Elongation Complex";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"B-WICH complex positively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"NoRC negatively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Elongation";"PIWI-interacting RNA (piRNA) biogenesis";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase III Transcription Termination";"Dual incision in TC-NER";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"MicroRNA (miRNA) biogenesis";"mRNA Splicing - Major Pathway";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Signaling by FGFR2 IIIa TM";"Pausing and recovery of HIV elongation"
APLA002559-PA	4	Reactome: R-HSA-3656532;Reactome: R-HSA-3304356;Reactome: R-HSA-2173788;Reactome: R-HSA-2173789	"TGFBR1 KD Mutants in Cancer";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"Downregulation of TGF-beta receptor signaling";"TGF-beta receptor signaling activates SMADs"
APLA001290-PA	27	Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-5619107;Reactome: R-HSA-170822;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-4570464;Reactome: R-HSA-3301854;Reactome: R-HSA-159230;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-4085377	"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"SUMOylation of RNA binding proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"ISG15 antiviral mechanism";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of SUMOylation proteins"
APLA008987-PA	56	Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-69017;Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-5610780;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-180585;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-8939236;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-195253;Reactome: R-HSA-5632684	"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"CDK-mediated phosphorylation and removal of Cdc6";"Defective CFTR causes cystic fibrosis";"Neddylation";"Separation of Sister Chromatids";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"Degradation of GLI1 by the proteasome";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Degradation of AXIN";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Vif-mediated degradation of APOBEC3G";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state"
APLA002135-PA	7	Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
APLA014955-PA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
APLA007957-PA	4	Reactome: R-HSA-5579026;Reactome: R-HSA-211976;Reactome: R-HSA-196108;Reactome: R-HSA-2395516	"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Endogenous sterols";"Pregnenolone biosynthesis";"Electron transport from NADPH to Ferredoxin"
APLA008159-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA003566-PA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-6798695	"Glycosphingolipid metabolism";"Neutrophil degranulation"
APLA015153-PA	8	Reactome: R-HSA-74217;MetaCyc: PWY-7179-1;KEGG: 00230+3.5.4.4;Reactome: R-HSA-6798695;MetaCyc: PWY-7179;MetaCyc: PWY-6609;MetaCyc: PWY-6611;Reactome: R-HSA-5683826	"Purine salvage";"Purine deoxyribonucleosides degradation II";"Purine metabolism";"Neutrophil degranulation";"Purine deoxyribonucleosides degradation I";"Adenine and adenosine salvage III";"Adenine and adenosine salvage V";"Surfactant metabolism"
APLA004795-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA011684-PA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
APLA014841-PA	26	Reactome: R-HSA-110312;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-1362277;Reactome: R-HSA-110320;Reactome: R-HSA-174417;Reactome: R-HSA-6782135;Reactome: R-HSA-5358606;Reactome: R-HSA-69091;Reactome: R-HSA-5656121;Reactome: R-HSA-6804114;Reactome: R-HSA-6782210;Reactome: R-HSA-69166;Reactome: R-HSA-5651801;Reactome: R-HSA-5358565;Reactome: R-HSA-5655862;Reactome: R-HSA-110314;Reactome: R-HSA-174437;Reactome: R-HSA-5685942;Reactome: R-HSA-69205;Reactome: R-HSA-8866654;Reactome: R-HSA-174414;Reactome: R-HSA-5696397;Reactome: R-HSA-4615885	"Translesion synthesis by REV1";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Transcription of E2F targets under negative control by DREAM complex";"Translesion Synthesis by POLH";"Telomere C-strand (Lagging Strand) Synthesis";"Dual incision in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Polymerase switching";"Translesion synthesis by POLI";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Removal of the Flap Intermediate";"PCNA-Dependent Long Patch Base Excision Repair";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion synthesis by POLK";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate from the C-strand";"HDR through Homologous Recombination (HRR)";"G1/S-Specific Transcription";"E3 ubiquitin ligases ubiquitinate target proteins";"Processive synthesis on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in GG-NER";"SUMOylation of DNA replication proteins"
APLA002856-PA	6	Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
APLA011670-PA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
APLA005232-PA	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
APLA014443-PA	15	Reactome: R-HSA-5685938;Reactome: R-HSA-5685939;Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5693554;Reactome: R-HSA-5693565;Reactome: R-HSA-2559586;Reactome: R-HSA-5693548;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568	"HDR through Single Strand Annealing (SSA)";"HDR through MMEJ (alt-NHEJ)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"DNA Damage/Telomere Stress Induced Senescence";"Sensing of DNA Double Strand Breaks";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
APLA001935-PA	3	Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148	"Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
APLA005777-PA	2	Reactome: R-HSA-2514853;Reactome: R-HSA-2299718	"Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes"
APLA000522-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA010466-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA015390-PA	3	KEGG: 00350+1.13.11.5;KEGG: 00643+1.13.11.5;Reactome: R-HSA-8963684	"Tyrosine metabolism";"Styrene degradation";"Tyrosine catabolism"
APLA009719-PA	3	Reactome: R-HSA-6807505;Reactome: R-HSA-76071;Reactome: R-HSA-749476	"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
APLA000133-PA	5	MetaCyc: PWY-7279;MetaCyc: PWY-7082;KEGG: 00190+7.1.1.8;MetaCyc: PWY-3781;MetaCyc: PWY-6692	"Aerobic respiration II (cytochrome c) (yeast)";"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Oxidative phosphorylation";"Aerobic respiration I (cytochrome c)";"Fe(II) oxidation"
APLA000824-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA002082-PA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
APLA002689-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA010791-PA	57	Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5678895;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-5610780;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-180534;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-5607764;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-6798695;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-8939236	"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Neddylation";"Separation of Sister Chromatids";"Defective CFTR causes cystic fibrosis";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"Degradation of GLI1 by the proteasome";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"CLEC7A (Dectin-1) signaling";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Degradation of AXIN";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Neutrophil degranulation";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
APLA011230-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA005730-PA	13	KEGG: 00670+6.3.4.3;MetaCyc: PWY-2161;Reactome: R-HSA-196757;MetaCyc: PWY-6613;KEGG: 00720+6.3.4.3;MetaCyc: PWY-2201;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-1722;MetaCyc: PWY-7909;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-5030;MetaCyc: PWY-3841;MetaCyc: PWY-5497	"One carbon pool by folate";"Folate polyglutamylation";"Metabolism of folate and pterines";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Carbon fixation pathways in prokaryotes";"Folate transformations I";"Carbon fixation pathways in prokaryotes";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"One carbon pool by folate";"L-histidine degradation III";"Folate transformations II (plants)";"Purine nucleobases degradation II (anaerobic)"
APLA014026-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
APLA012797-PA	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
APLA006510-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA005305-PA	4	Reactome: R-HSA-8874211;Reactome: R-HSA-8963889;Reactome: R-HSA-381033;Reactome: R-HSA-1655829	"CREB3 factors activate genes";"Assembly of active LPL and LIPC lipase complexes";"ATF6 (ATF6-alpha) activates chaperones";"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
APLA008443-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA004792-PA	3	Reactome: R-HSA-4086398;Reactome: R-HSA-418457;Reactome: R-HSA-392517	"Ca2+ pathway";"cGMP effects";"Rap1 signalling"
APLA000959-PA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
APLA004273-PA	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
APLA009479-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA009488-PA	5	Reactome: R-HSA-901042;Reactome: R-HSA-381426;Reactome: R-HSA-879415;Reactome: R-HSA-8957275;Reactome: R-HSA-532668	"Calnexin/calreticulin cycle";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Advanced glycosylation endproduct receptor signaling";"Post-translational protein phosphorylation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
APLA008652-PA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
APLA009971-PA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
APLA012338-PA	24	Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-983189;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-3371497;Reactome: R-HSA-9609736;Reactome: R-HSA-9619483;Reactome: R-HSA-5617833;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-8955332	"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Kinesins";"Gap junction assembly";"HCMV Early Events";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Assembly and cell surface presentation of NMDA receptors";"Activation of AMPK downstream of NMDARs";"Cilium Assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Carboxyterminal post-translational modifications of tubulin"
APLA000699-PA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
APLA007256-PA	3	Reactome: R-HSA-5173105;Reactome: R-HSA-5083633;Reactome: R-HSA-5083629	"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2"
APLA013590-PA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
APLA005447-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA013080-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA005622-PA	4	KEGG: 00030+1.1.1.49;MetaCyc: PWY-8004;KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268	"Pentose phosphate pathway";"Entner-Doudoroff pathway I";"Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
APLA005245-PA	17	Reactome: R-HSA-170660;Reactome: R-HSA-164378;Reactome: R-HSA-1655829;Reactome: R-HSA-381426;Reactome: R-HSA-8874211;Reactome: R-HSA-8963889;Reactome: R-HSA-5610787;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-170670;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-163615;Reactome: R-HSA-8957275;Reactome: R-HSA-381033;Reactome: R-HSA-163359;Reactome: R-HSA-432040	"Adenylate cyclase activating pathway";"PKA activation in glucagon signalling";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"CREB3 factors activate genes";"Assembly of active LPL and LIPC lipase complexes";"Hedgehog 'off' state";"G alpha (s) signalling events";"G alpha (z) signalling events";"Adenylate cyclase inhibitory pathway";"G alpha (i) signalling events";"Purine metabolism";"PKA activation";"Post-translational protein phosphorylation";"ATF6 (ATF6-alpha) activates chaperones";"Glucagon signaling in metabolic regulation";"Vasopressin regulates renal water homeostasis via Aquaporins"
APLA010545-PA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
APLA013003-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA003894-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA004976-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA011712-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA010657-PA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440	"COPI-mediated anterograde transport";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network"
APLA005894-PA	6	Reactome: R-HSA-111367;Reactome: R-HSA-77588;Reactome: R-HSA-191859;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72165	"SLBP independent Processing of Histone Pre-mRNAs";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"snRNP Assembly";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Minor Pathway"
APLA005654-PA	1	Reactome: R-HSA-70350	"Fructose catabolism"
APLA011123-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA003183-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA001105-PA	6	Reactome: R-HSA-450385;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450604	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA"
APLA012736-PA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-264870;Reactome: R-HSA-6794361	"Neutrophil degranulation";"Caspase-mediated cleavage of cytoskeletal proteins";"Neurexins and neuroligins"
APLA008705-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA012401-PA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
APLA006163-PA	1	Reactome: R-HSA-1483148	"Synthesis of PG"
APLA000171-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA003558-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA009835-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA007047-PA	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
APLA004548-PA	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
APLA004393-PA	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
APLA006607-PA	30	Reactome: R-HSA-917937;Reactome: R-HSA-1170546;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-5610785;Reactome: R-HSA-2871837;Reactome: R-HSA-2565942;Reactome: R-HSA-983168;Reactome: R-HSA-2894862;Reactome: R-HSA-9020702;Reactome: R-HSA-5684264;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-8951664;Reactome: R-HSA-5610783;Reactome: R-HSA-2644606;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-400253;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-2122947;Reactome: R-HSA-69231;Reactome: R-HSA-5610780;Reactome: R-HSA-2644607;Reactome: R-HSA-202424;Reactome: R-HSA-195253;Reactome: R-HSA-5676590	"Iron uptake and transport";"Prolactin receptor signaling";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"GLI3 is processed to GLI3R by the proteasome";"FCERI mediated NF-kB activation";"Regulation of PLK1 Activity at G2/M Transition";"Antigen processing: Ubiquitination & Proteasome degradation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Interleukin-1 signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Neddylation";"Degradation of GLI2 by the proteasome";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Circadian Clock";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"Cyclin D associated events in G1";"Degradation of GLI1 by the proteasome";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Downstream TCR signaling";"Degradation of beta-catenin by the destruction complex";"NIK-->noncanonical NF-kB signaling"
APLA008347-PA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
APLA015239-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA005262-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA003818-PA	10	MetaCyc: PWY-1042;KEGG: 00010+2.7.2.3;Reactome: R-HSA-70263;MetaCyc: PWY-6901;MetaCyc: PWY-6886;MetaCyc: PWY-5484;Reactome: R-HSA-70171;KEGG: 00710+2.7.2.3;MetaCyc: PWY-8004;MetaCyc: PWY-7003	"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Superpathway of glucose and xylose degradation";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Carbon fixation in photosynthetic organisms";"Entner-Doudoroff pathway I";"Glycerol degradation to butanol"
APLA013223-PA	56	Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-5362768;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-450408;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-5658442;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5678895;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902	"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RAS by GAPs";"Neddylation";"Separation of Sister Chromatids";"Defective CFTR causes cystic fibrosis";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Regulation of RUNX2 expression and activity"
APLA008348-PA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
APLA005364-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA011678-PA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA008217-PA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
APLA000912-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA005787-PA	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
APLA009851-PA	2	Reactome: R-HSA-8963888;Reactome: R-HSA-8866423	"Chylomicron assembly";"VLDL assembly"
APLA015268-PA	15	MetaCyc: PWY-5484;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6886;MetaCyc: PWY-7383;MetaCyc: PWY-6901;KEGG: 00230+2.7.1.40;MetaCyc: PWY-6142;MetaCyc: PWY-1042;MetaCyc: PWY-7218;MetaCyc: PWY-8004;MetaCyc: PWY-7003;MetaCyc: PWY-5723;Reactome: R-HSA-70171;KEGG: 00010+2.7.1.40;MetaCyc: PWY-2221	"Glycolysis II (from fructose 6-phosphate)";"Pyruvate metabolism";"1-butanol autotrophic biosynthesis (engineered)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Superpathway of glucose and xylose degradation";"Purine metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Entner-Doudoroff pathway I";"Glycerol degradation to butanol";"Rubisco shunt";"Glycolysis";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)"
APLA003234-PA	2	Reactome: R-HSA-1236974;Reactome: R-HSA-1799339	"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane"
APLA014029-PA	10	Reactome: R-HSA-156827;Reactome: R-HSA-72731;Reactome: R-HSA-9648895;Reactome: R-HSA-382556;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-381042	"L13a-mediated translational silencing of Ceruloplasmin expression";"Recycling of eIF2:GDP";"Response of EIF2AK1 (HRI) to heme deficiency";"ABC-family proteins mediated transport";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"PERK regulates gene expression"
APLA000186-PA	4	Reactome: R-HSA-499943;KEGG: 00590+5.3.99.3;Reactome: R-HSA-2162123;Reactome: R-HSA-6798695	"Interconversion of nucleotide di- and triphosphates";"Arachidonic acid metabolism";"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)";"Neutrophil degranulation"
APLA002049-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA013323-PA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
APLA014624-PA	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
APLA006659-PA	8	KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-975957;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"mTOR signaling pathway";"Thermogenesis";"PI3K-Akt signaling pathway";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
APLA015036-PA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
APLA008872-PA	5	Reactome: R-HSA-174490;Reactome: R-HSA-917729;Reactome: R-HSA-9615710;Reactome: R-HSA-9610379;Reactome: R-HSA-162588	"Membrane binding and targetting of GAG proteins";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy";"HCMV Late Events";"Budding and maturation of HIV virion"
APLA009431-PA	3	Reactome: R-HSA-2995383;Reactome: R-HSA-2980766;Reactome: R-HSA-4419969	"Initiation of Nuclear Envelope Reformation";"Nuclear Envelope Breakdown";"Depolymerisation of the Nuclear Lamina"
APLA004009-PA	7	MetaCyc: PWY-6724;KEGG: 00500+2.4.1.25;MetaCyc: PWY-7238;Reactome: R-HSA-6798695;MetaCyc: PWY-5941;MetaCyc: PWY-6737;Reactome: R-HSA-70221	"Starch degradation II";"Starch and sucrose metabolism";"Sucrose biosynthesis II";"Neutrophil degranulation";"Glycogen degradation II";"Starch degradation V";"Glycogen breakdown (glycogenolysis)"
APLA005259-PA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
APLA006385-PA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
APLA001036-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA014667-PA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA010474-PA	5	MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922	"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)"
APLA004042-PA	2	Reactome: R-HSA-8964539;Reactome: R-HSA-2151201	"Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis"
APLA006779-PA	6	MetaCyc: PWY-1622;KEGG: 00680+5.4.2.11;KEGG: 00010+5.4.2.11;MetaCyc: PWY-8004;MetaCyc: PWY-5484;KEGG: 00260+5.4.2.11	"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway I";"Glycolysis II (from fructose 6-phosphate)";"Glycine, serine and threonine metabolism"
APLA007647-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA003267-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA015296-PA	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
APLA013706-PA	10	KEGG: 00051+2.7.1.11;KEGG: 00010+2.7.1.11;MetaCyc: PWY-7385;Reactome: R-HSA-70171;MetaCyc: PWY-1861;MetaCyc: PWY-5484;KEGG: 00052+2.7.1.11;MetaCyc: PWY-1042;KEGG: 00680+2.7.1.11;KEGG: 00030+2.7.1.11	"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Galactose metabolism";"Glycolysis IV (plant cytosol)";"Methane metabolism";"Pentose phosphate pathway"
APLA000721-PA	2	Reactome: R-HSA-204005;Reactome: R-HSA-6783310	"COPII-mediated vesicle transport";"Fanconi Anemia Pathway"
APLA003517-PA	8	KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Signaling by Hippo";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
APLA004551-PA	2	Reactome: R-HSA-6787450;Reactome: R-HSA-6782315	"tRNA modification in the mitochondrion";"tRNA modification in the nucleus and cytosol"
APLA012402-PA	7	MetaCyc: PWY-7836;MetaCyc: PWY-7838;MetaCyc: PWY-7839;MetaCyc: PWY-5129;KEGG: 00600+2.4.1.80;Reactome: R-HSA-1660662;MetaCyc: PWY-7841	"Ganglio-series glycosphingolipids biosynthesis";"Globo-series glycosphingolipids biosynthesis";"Lacto-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)";"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Neolacto-series glycosphingolipids biosynthesis"
APLA005856-PA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs"
APLA004655-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA010009-PA	2	Reactome: R-HSA-426486;Reactome: R-HSA-203927	"Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis"
APLA003990-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA002880-PA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
APLA001906-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA009417-PA	26	Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-5663220;Reactome: R-HSA-8852276;Reactome: R-HSA-389977;Reactome: R-HSA-6811434;Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-8955332;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-983189;Reactome: R-HSA-389960;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-380320;Reactome: R-HSA-2132295	"Aggrephagy";"Separation of Sister Chromatids";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Post-chaperonin tubulin folding pathway";"COPI-dependent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Carboxyterminal post-translational modifications of tubulin";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Kinesins";"Formation of tubulin folding intermediates by CCT/TriC";"HCMV Early Events";"Gap junction assembly";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"Cilium Assembly";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Recruitment of NuMA to mitotic centrosomes";"MHC class II antigen presentation"
APLA014982-PA	1	Reactome: R-HSA-6806664	"Metabolism of vitamin K"
APLA000169-PA	1	Reactome: R-HSA-8849175	"Threonine catabolism"
APLA004329-PA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
APLA000688-PA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-171319	"HATs acetylate histones";"Telomere Extension By Telomerase"
APLA002288-PA	179	Reactome: R-HSA-156827;Reactome: R-HSA-8854050;Reactome: R-HSA-5357905;Reactome: R-HSA-5610783;Reactome: R-HSA-3769402;Reactome: R-HSA-5693565;Reactome: R-HSA-174113;Reactome: R-HSA-8866654;Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-6781827;Reactome: R-HSA-6791226;Reactome: R-HSA-9014325;Reactome: R-HSA-2173788;Reactome: R-HSA-6782210;Reactome: R-HSA-180585;Reactome: R-HSA-975110;Reactome: R-HSA-6783310;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-8875360;Reactome: R-HSA-450302;Reactome: R-HSA-8866652;Reactome: R-HSA-5685942;Reactome: R-HSA-69017;Reactome: R-HSA-5655862;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-2979096;Reactome: R-HSA-5205685;Reactome: R-HSA-1799339;Reactome: R-HSA-5696397;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-174048;Reactome: R-HSA-174154;Reactome: R-HSA-2173796;Reactome: R-HSA-110312;Reactome: R-HSA-9633012;Reactome: R-HSA-180534;Reactome: R-HSA-211733;Reactome: R-HSA-5654726;Reactome: R-HSA-72689;Reactome: R-HSA-69231;Reactome: R-HSA-110314;Reactome: R-HSA-72764;Reactome: R-HSA-6804757;Reactome: R-HSA-9033241;Reactome: R-HSA-8856828;Reactome: R-HSA-917937;Reactome: R-HSA-69601;Reactome: R-HSA-382556;Reactome: R-HSA-5654733;Reactome: R-HSA-5689901;Reactome: R-HSA-187577;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-6804760;Reactome: R-HSA-2894862;Reactome: R-HSA-209560;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-977225;Reactome: R-HSA-195253;Reactome: R-HSA-2644606;Reactome: R-HSA-9615710;Reactome: R-HSA-1169091;Reactome: R-HSA-209543;Reactome: R-HSA-9010553;Reactome: R-HSA-5678895;Reactome: R-HSA-3322077;Reactome: R-HSA-975144;Reactome: R-HSA-174490;Reactome: R-HSA-936440;Reactome: R-HSA-937042;Reactome: R-HSA-1234176;Reactome: R-HSA-917729;Reactome: R-HSA-174178;Reactome: R-HSA-69481;Reactome: R-HSA-8948747;Reactome: R-HSA-5610780;Reactome: R-HSA-6804756;Reactome: R-HSA-5696400;Reactome: R-HSA-156902;Reactome: R-HSA-5676590;Reactome: R-HSA-445989;Reactome: R-HSA-5687128;Reactome: R-HSA-5607764;Reactome: R-HSA-901032;Reactome: R-HSA-201681;Reactome: R-HSA-8849469;Reactome: R-HSA-2122947;Reactome: R-HSA-936964;Reactome: R-HSA-8856825;Reactome: R-HSA-1236382;Reactome: R-HSA-937039;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-8876493;Reactome: R-HSA-5675221;Reactome: R-HSA-2173791;Reactome: R-HSA-174084;Reactome: R-HSA-5689877;Reactome: R-HSA-174184;Reactome: R-HSA-3134975;Reactome: R-HSA-2559585;Reactome: R-HSA-400253;Reactome: R-HSA-9604323;Reactome: R-HSA-5696395;Reactome: R-HSA-110320;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-5654727;Reactome: R-HSA-2173795;Reactome: R-HSA-6781823;Reactome: R-HSA-1236974;Reactome: R-HSA-72706;Reactome: R-HSA-69541;Reactome: R-HSA-5689896;Reactome: R-HSA-975957;Reactome: R-HSA-5610785;Reactome: R-HSA-532668;Reactome: R-HSA-450408;Reactome: R-HSA-5654732;Reactome: R-HSA-2565942;Reactome: R-HSA-2672351;Reactome: R-HSA-2408557;Reactome: R-HSA-9637628;Reactome: R-HSA-2122948;Reactome: R-HSA-182971;Reactome: R-HSA-937041;Reactome: R-HSA-2691232;Reactome: R-HSA-5675482;Reactome: R-HSA-5656169;Reactome: R-HSA-975163;Reactome: R-HSA-937072;Reactome: R-HSA-168927;Reactome: R-HSA-5656121;Reactome: R-HSA-6782135;Reactome: R-HSA-168928;Reactome: R-HSA-175474;Reactome: R-HSA-4641263;Reactome: R-HSA-9013507;Reactome: R-HSA-6807004;Reactome: R-HSA-5693607;Reactome: R-HSA-205043;Reactome: R-HSA-2559580;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-2871837;Reactome: R-HSA-9613829;Reactome: R-HSA-168638;Reactome: R-HSA-162588;Reactome: R-HSA-9636383;Reactome: R-HSA-5632684;Reactome: R-HSA-912631;Reactome: R-HSA-1169408;Reactome: R-HSA-450321;Reactome: R-HSA-8939236;Reactome: R-HSA-5684264;Reactome: R-HSA-192823;Reactome: R-HSA-1358803;Reactome: R-HSA-5357956;Reactome: R-HSA-1253288;Reactome: R-HSA-4608870;Reactome: R-HSA-5696394;Reactome: R-HSA-8948751;Reactome: R-HSA-9645460;Reactome: R-HSA-9020702;Reactome: R-HSA-9013973;Reactome: R-HSA-975956;Reactome: R-HSA-3785653;Reactome: R-HSA-8863795;Reactome: R-HSA-202424;Reactome: R-HSA-1295596	"L13a-mediated translational silencing of Ceruloplasmin expression";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of TNFR1 signaling";"Degradation of GLI2 by the proteasome";"Deactivation of the beta-catenin transactivating complex";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"SCF-beta-TrCP mediated degradation of Emi1";"E3 ubiquitin ligases ubiquitinate target proteins";"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Major pathway of rRNA processing in the nucleolus and cytosol";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Downregulation of TGF-beta receptor signaling";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Vif-mediated degradation of APOBEC3G";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"Fanconi Anemia Pathway";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"InlB-mediated entry of Listeria monocytogenes into host cell";"activated TAK1 mediates p38 MAPK activation";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"HDR through Homologous Recombination (HRR)";"CDK-mediated phosphorylation and removal of Cdc6";"Translesion synthesis by POLK";"Aggrephagy";"Separation of Sister Chromatids";"Neddylation";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Pink/Parkin Mediated Mitophagy";"SRP-dependent cotranslational protein targeting to membrane";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC/C:Cdc20 mediated degradation of Securin";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Translesion synthesis by REV1";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Vpu mediated degradation of CD4";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Negative regulation of FGFR1 signaling";"Formation of a pool of free 40S subunits";"Cyclin D associated events in G1";"Recognition of DNA damage by PCNA-containing replication complex";"Eukaryotic Translation Termination";"Regulation of TP53 Degradation";"Peroxisomal protein import";"Clathrin-mediated endocytosis";"Iron uptake and transport";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ABC-family proteins mediated transport";"Negative regulation of FGFR4 signaling";"Metalloprotease DUBs";"SCF(Skp2)-mediated degradation of p27/p21";"UCH proteinases";"Degradation of AXIN";"Regulation of TP53 Activity through Methylation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NF-kB is activated and signals survival";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Amyloid fiber formation";"Degradation of beta-catenin by the destruction complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Late endosomal microautophagy";"Activation of NF-kappaB in B cells";"p75NTR recruits signalling complexes";"Regulation of expression of SLITs and ROBOs";"Defective CFTR causes cystic fibrosis";"Glycogen synthesis";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Membrane binding and targetting of GAG proteins";"Negative regulators of DDX58/IFIH1 signaling";"IRAK2 mediated activation of TAK1 complex";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Endosomal Sorting Complex Required For Transport (ESCRT)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"G2/M Checkpoints";"Regulation of PTEN localization";"Degradation of GLI1 by the proteasome";"Regulation of TP53 Activity through Phosphorylation";"Dual Incision in GG-NER";"Peptide chain elongation";"NIK-->noncanonical NF-kB signaling";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"MAPK6/MAPK4 signaling";"CLEC7A (Dectin-1) signaling";"ER Quality Control Compartment (ERQC)";"TCF dependent signaling in response to WNT";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"NOTCH1 Intracellular Domain Regulates Transcription";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Cargo recognition for clathrin-mediated endocytosis";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"IRAK1 recruits IKK complex";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"InlA-mediated entry of Listeria monocytogenes into host cells";"Negative regulation of MAPK pathway";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Josephin domain DUBs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of innate immune responses to cytosolic DNA";"Oncogene Induced Senescence";"Circadian Clock";"Negative regulation of NOTCH4 signaling";"Formation of Incision Complex in GG-NER";"Translesion Synthesis by POLH";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Negative regulation of FGFR2 signaling";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Formation of TC-NER Pre-Incision Complex";"ER-Phagosome pathway";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Stabilization of p53";"Ovarian tumor domain proteases";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GLI3 is processed to GLI3R by the proteasome";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Negative regulation of FGFR3 signaling";"Regulation of PLK1 Activity at G2/M Transition";"Stimuli-sensing channels";"Selenocysteine synthesis";"Modulation by Mtb of host immune system";"Activated NOTCH1 Transmits Signal to the Nucleus";"EGFR downregulation";"IKK complex recruitment mediated by RIP1";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Regulation of necroptotic cell death";"Termination of translesion DNA synthesis";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TICAM1, RIP1-mediated IKK complex recruitment";"Translesion synthesis by POLI";"Dual incision in TC-NER";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Assembly Of The HIV Virion";"Regulation of FZD by ubiquitination";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Negative regulation of MET activity";"Processing of DNA double-strand break ends";"NRIF signals cell death from the nucleus";"Oxidative Stress Induced Senescence";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"FCERI mediated NF-kB activation";"Chaperone Mediated Autophagy";"NOD1/2 Signaling Pathway";"Budding and maturation of HIV virion";"Prevention of phagosomal-lysosomal fusion";"Hedgehog 'on' state";"Regulation of signaling by CBL";"ISG15 antiviral mechanism";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Viral mRNA Translation";"Downregulation of ERBB2:ERBB3 signaling";"TNFR1-induced NFkappaB signaling pathway";"Downregulation of ERBB4 signaling";"Asymmetric localization of PCP proteins";"DNA Damage Recognition in GG-NER";"Regulation of PTEN stability and activity";"Alpha-protein kinase 1 signaling pathway";"Interleukin-1 signaling";"TICAM1-dependent activation of IRF3/IRF7";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Myoclonic epilepsy of Lafora";"Downregulation of ERBB2 signaling";"Downstream TCR signaling";"Spry regulation of FGF signaling"
APLA010534-PA	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
APLA009452-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA013622-PA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
APLA008605-PA	5	MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922	"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)"
APLA006339-PA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6	"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism"
APLA001606-PA	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
APLA008263-PA	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
APLA000812-PA	1	Reactome: R-HSA-5419276	"Mitochondrial translation termination"
APLA008935-PA	6	KEGG: 00230+6.3.2.6;KEGG: 00230+4.1.1.21;MetaCyc: PWY-7234;MetaCyc: PWY-6124;Reactome: R-HSA-73817;MetaCyc: PWY-6123	"Purine metabolism";"Purine metabolism";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis I"
APLA002535-PA	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
APLA010349-PA	5	MetaCyc: PWY-7177;KEGG: 00240+6.3.4.2;Reactome: R-HSA-499943;MetaCyc: PWY-7185;MetaCyc: PWY-7176	"UTP and CTP dephosphorylation II";"Pyrimidine metabolism";"Interconversion of nucleotide di- and triphosphates";"UTP and CTP dephosphorylation I";"UTP and CTP de novo biosynthesis"
APLA012079-PA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
APLA013639-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA013963-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA013653-PA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
APLA012987-PA	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
APLA000940-PA	16	Reactome: R-HSA-176408;Reactome: R-HSA-69017;Reactome: R-HSA-176407;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-174084;Reactome: R-HSA-174048;Reactome: R-HSA-174184;Reactome: R-HSA-176412;Reactome: R-HSA-2559582;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-141430;Reactome: R-HSA-176409;Reactome: R-HSA-8853884	"Regulation of APC/C activators between G1/S and early anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Cyclin B";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Phosphorylation of the APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Transcriptional Regulation by VENTX"
APLA006049-PA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
APLA011784-PA	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
APLA002118-PA	3	MetaCyc: PWY-7833;MetaCyc: PWY-7831;Reactome: R-HSA-9033807	"Biosynthesis of Lewis epitopes (H. pylori)";"ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide";"ABO blood group biosynthesis"
APLA013597-PA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA014013-PA	2	Reactome: R-HSA-174403;Reactome: R-HSA-5578998	"Glutathione synthesis and recycling";"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)"
APLA007319-PA	6	Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-72689	"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits"
APLA014865-PA	1	Reactome: R-HSA-977443	"GABA receptor activation"
APLA003559-PA	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway"
APLA012609-PA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
APLA006758-PA	1	Reactome: R-HSA-525793	"Myogenesis"
APLA002656-PA	2	Reactome: R-HSA-6783984;KEGG: 00260+1.4.4.2	"Glycine degradation";"Glycine, serine and threonine metabolism"
APLA006975-PA	56	Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-187577;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-450408;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-1236974;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534	"Degradation of GLI2 by the proteasome";"Degradation of DVL";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"SCF(Skp2)-mediated degradation of p27/p21";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"Separation of Sister Chromatids";"Neddylation";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ER-Phagosome pathway";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4"
APLA012530-PA	5	MetaCyc: PWY-6122;MetaCyc: PWY-6277;Reactome: R-HSA-73817;MetaCyc: PWY-6121;KEGG: 00230+6.3.5.3	"5-aminoimidazole ribonucleotide biosynthesis II";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism"
APLA009863-PA	2	KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1	"Purine metabolism";"Pentose phosphate pathway"
APLA001849-PA	3	Reactome: R-HSA-6799198;Reactome: R-HSA-611105;Reactome: R-HSA-1268020	"Complex I biogenesis";"Respiratory electron transport";"Mitochondrial protein import"
APLA012726-PA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
APLA003086-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA004504-PA	57	Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-4641257;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-6798695;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-1236974;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5678895;Reactome: R-HSA-180534;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-5607764;Reactome: R-HSA-174178;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-5610780;Reactome: R-HSA-202424;Reactome: R-HSA-5676590	"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of AXIN";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Neutrophil degranulation";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"ER-Phagosome pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Neddylation";"Defective CFTR causes cystic fibrosis";"Vpu mediated degradation of CD4";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"CLEC7A (Dectin-1) signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"Degradation of GLI1 by the proteasome";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling"
APLA007701-PA	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
APLA009149-PA	14	Reactome: R-HSA-2022377;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Metabolism of Angiotensinogen to Angiotensins";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
APLA006867-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA001350-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA003587-PA	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
APLA004174-PA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6	"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism"
APLA014138-PA	3	KEGG: 00790+4.2.1.96;MetaCyc: PWY-8099;MetaCyc: PWY-7158	"Folate biosynthesis";"Tetrahydropteridine recycling";"L-phenylalanine degradation V"
APLA008297-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA007672-PA	1	Reactome: R-HSA-1614558	"Degradation of cysteine and homocysteine"
APLA011335-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA007698-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA013918-PA	5	Reactome: R-HSA-5205685;Reactome: R-HSA-983168;Reactome: R-HSA-5689877;Reactome: R-HSA-977225;Reactome: R-HSA-9646399	"Pink/Parkin Mediated Mitophagy";"Antigen processing: Ubiquitination & Proteasome degradation";"Josephin domain DUBs";"Amyloid fiber formation";"Aggrephagy"
APLA007917-PA	6	Reactome: R-HSA-456926;Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-399997;Reactome: R-HSA-416476;Reactome: R-HSA-428930	"Thrombin signalling through proteinase activated receptors (PARs)";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Acetylcholine regulates insulin secretion";"G alpha (q) signalling events";"Thromboxane signalling through TP receptor"
APLA002314-PA	1	Reactome: R-HSA-446210	"Synthesis of UDP-N-acetyl-glucosamine"
APLA006993-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA015287-PA	2	Reactome: R-HSA-2032785;Reactome: R-HSA-8951671	"YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription"
APLA004645-PA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
APLA014742-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA002937-PA	27	Reactome: R-HSA-975956;Reactome: R-HSA-72163;Reactome: R-HSA-159231;Reactome: R-HSA-8851708;Reactome: R-HSA-159230;Reactome: R-HSA-6807505;Reactome: R-HSA-112382;Reactome: R-HSA-72165;Reactome: R-HSA-159227;Reactome: R-HSA-167242;Reactome: R-HSA-77588;Reactome: R-HSA-72203;Reactome: R-HSA-9010553;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-674695;Reactome: R-HSA-111367;Reactome: R-HSA-6803529;Reactome: R-HSA-975957;Reactome: R-HSA-77595	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA Derived from an Intronless Transcript";"Signaling by FGFR2 IIIa TM";"Transport of the SLBP Dependant Mature mRNA";"RNA polymerase II transcribes snRNA genes";"Formation of RNA Pol II elongation complex";"mRNA Splicing - Minor Pathway";"Transport of the SLBP independent Mature mRNA";"Abortive elongation of HIV-1 transcript in the absence of Tat";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"Processing of Capped Intron-Containing Pre-mRNA";"Regulation of expression of SLITs and ROBOs";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Pre-transcription Events";"SLBP independent Processing of Histone Pre-mRNAs";"FGFR2 alternative splicing";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Processing of Intronless Pre-mRNAs"
APLA007929-PA	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
APLA011273-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA010823-PA	6	MetaCyc: PWY-5744;MetaCyc: PWY-5789;MetaCyc: PWY-6722;MetaCyc: PWY-5743;Reactome: R-HSA-196780;MetaCyc: PWY-4381	"Glyoxylate assimilation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Candicidin biosynthesis";"3-hydroxypropanoate cycle";"Biotin transport and metabolism";"Fatty acid biosynthesis initiation (bacteria and plants)"
APLA010387-PA	14	Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-5655862;Reactome: R-HSA-5656169;Reactome: R-HSA-5696400;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-5696397;Reactome: R-HSA-6782210;Reactome: R-HSA-5656121;Reactome: R-HSA-69091;Reactome: R-HSA-6782135;Reactome: R-HSA-110320	"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLK";"Termination of translesion DNA synthesis";"Dual Incision in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by POLI";"Polymerase switching";"Dual incision in TC-NER";"Translesion Synthesis by POLH"
APLA009344-PA	5	Reactome: R-HSA-73863;Reactome: R-HSA-73772;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-5250924	"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression"
APLA015064-PA	9	Reactome: R-HSA-1368108;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-400206;Reactome: R-HSA-1368082;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-5617472	"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"Regulation of lipid metabolism by PPARalpha";"RORA activates gene expression";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
APLA014746-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA003731-PA	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions"
APLA007491-PA	7	KEGG: 00230+4.3.2.2;MetaCyc: PWY-6124;MetaCyc: PWY-6123;Reactome: R-HSA-73817;MetaCyc: PWY-7234;KEGG: 00250+4.3.2.2;MetaCyc: PWY-7219	"Purine metabolism";"Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Adenosine ribonucleotides de novo biosynthesis"
APLA003152-PA	2	Reactome: R-HSA-6783984;Reactome: R-HSA-389661	"Glycine degradation";"Glyoxylate metabolism and glycine degradation"
APLA007458-PA	3	KEGG: 00531+3.2.1.50;Reactome: R-HSA-2206282;Reactome: R-HSA-2024096	"Glycosaminoglycan degradation";"MPS IIIB - Sanfilippo syndrome B";"HS-GAG degradation"
APLA011585-PA	1	Reactome: R-HSA-901032	"ER Quality Control Compartment (ERQC)"
APLA002065-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA003544-PA	19	Reactome: R-HSA-8963888;Reactome: R-HSA-3000484;Reactome: R-HSA-8957275;Reactome: R-HSA-3000480;Reactome: R-HSA-8964038;Reactome: R-HSA-432142;Reactome: R-HSA-8856828;Reactome: R-HSA-5686938;Reactome: R-HSA-381426;Reactome: R-HSA-8963901;Reactome: R-HSA-8866423;Reactome: R-HSA-202733;Reactome: R-HSA-3000497;Reactome: R-HSA-8964041;Reactome: R-HSA-3000471;Reactome: R-HSA-8964026;Reactome: R-HSA-8856825;Reactome: R-HSA-975634;Reactome: R-HSA-8964046	"Chylomicron assembly";"Scavenging by Class F Receptors";"Post-translational protein phosphorylation";"Scavenging by Class A Receptors";"LDL clearance";"Platelet sensitization by LDL";"Clathrin-mediated endocytosis";"Regulation of TLR by endogenous ligand";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Chylomicron remodeling";"VLDL assembly";"Cell surface interactions at the vascular wall";"Scavenging by Class H Receptors";"LDL remodeling";"Scavenging by Class B Receptors";"Chylomicron clearance";"Cargo recognition for clathrin-mediated endocytosis";"Retinoid metabolism and transport";"VLDL clearance"
APLA005017-PA	16	Reactome: R-HSA-174048;Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-69017;Reactome: R-HSA-176408;Reactome: R-HSA-2467813;Reactome: R-HSA-176407;Reactome: R-HSA-176409;Reactome: R-HSA-8853884;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-174184;Reactome: R-HSA-2559582;Reactome: R-HSA-176412;Reactome: R-HSA-141430	"APC/C:Cdc20 mediated degradation of Cyclin B";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of APC/C activators between G1/S and early anaphase";"Separation of Sister Chromatids";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Senescence-Associated Secretory Phenotype (SASP)";"Phosphorylation of the APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex"
APLA006786-PA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
APLA010091-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA015028-PA	56	Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5678895;Reactome: R-HSA-1236974;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-5362768;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-450408;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-180534;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-5607764;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-8852276;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-8939236	"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Neddylation";"Separation of Sister Chromatids";"Defective CFTR causes cystic fibrosis";"ER-Phagosome pathway";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"CLEC7A (Dectin-1) signaling";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
APLA011000-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA000726-PA	6	MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782	"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis"
APLA002051-PA	2	KEGG: 00051+5.3.1.5;KEGG: 00040+5.3.1.5	"Fructose and mannose metabolism";"Pentose and glucuronate interconversions"
APLA010578-PA	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
APLA005996-PA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
APLA007710-PA	4	Reactome: R-HSA-400511;Reactome: R-HSA-381771;Reactome: R-HSA-1799339;Reactome: R-HSA-422085	"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and deacylation of Ghrelin"
APLA009504-PA	4	Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex"
APLA004453-PA	5	Reactome: R-HSA-6807878;Reactome: R-HSA-983231;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497	"COPI-mediated anterograde transport";"Factors involved in megakaryocyte development and platelet production";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
APLA002850-PA	1	Reactome: R-HSA-211981	"Xenobiotics"
APLA010350-PA	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
APLA005611-PA	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
APLA000970-PA	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
APLA007645-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA010569-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA015235-PA	10	MetaCyc: PWY-5839;MetaCyc: PWY-5891;MetaCyc: PWY-5849;MetaCyc: PWY-5890;MetaCyc: PWY-5892;Reactome: R-HSA-2142789;MetaCyc: PWY-5895;MetaCyc: PWY-5844;KEGG: 00130+2.1.1.163;MetaCyc: PWY-7996	"Menaquinol-7 biosynthesis";"Menaquinol-11 biosynthesis";"Menaquinol-6 biosynthesis";"Menaquinol-10 biosynthesis";"Menaquinol-12 biosynthesis";"Ubiquinol biosynthesis";"Menaquinol-13 biosynthesis";"Menaquinol-9 biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Menaquinol-4 biosynthesis I"
APLA009666-PA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
APLA008756-PA	3	Reactome: R-HSA-6804760;Reactome: R-HSA-2299718;Reactome: R-HSA-3214841	"Regulation of TP53 Activity through Methylation";"Condensation of Prophase Chromosomes";"PKMTs methylate histone lysines"
APLA011767-PA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
APLA000816-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA001432-PA	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
APLA012790-PA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
APLA005952-PA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-6804758	"HATs acetylate histones";"Regulation of TP53 Activity through Acetylation"
APLA007395-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA004844-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA004984-PA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
APLA007049-PA	2	Reactome: R-HSA-2151201;Reactome: R-HSA-400253	"Transcriptional activation of mitochondrial biogenesis";"Circadian Clock"
APLA010202-PA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
APLA012865-PA	4	KEGG: 00564+3.1.1.32;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051	"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I"
APLA008362-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA008151-PA	8	KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2465910;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"MASTL Facilitates Mitotic Progression";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection"
APLA001971-PA	5	Reactome: R-HSA-199220;MetaCyc: PWY-6012;MetaCyc: PWY-6289;MetaCyc: PWY-6012-1;KEGG: 00770+2.7.8.7	"Vitamin B5 (pantothenate) metabolism";"Acyl carrier protein metabolism";"Petrobactin biosynthesis";"Acyl carrier protein activation";"Pantothenate and CoA biosynthesis"
APLA013239-PA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
APLA001848-PA	2	Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58	"Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis"
APLA015058-PA	33	Reactome: R-HSA-68877;Reactome: R-HSA-1169408;Reactome: R-HSA-180910;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-4570464;Reactome: R-HSA-9648025;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-6784531;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-141444;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-5619107;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220	"Mitotic Prometaphase";"ISG15 antiviral mechanism";"Vpr-mediated nuclear import of PICs";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of RNA binding proteins";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"tRNA processing in the nucleus";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Separation of Sister Chromatids";"RHO GTPases Activate Formins"
APLA012681-PA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
APLA007467-PA	5	KEGG: 00052+3.2.1.22;KEGG: 00561+3.2.1.22;KEGG: 00600+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00603+3.2.1.22	"Galactose metabolism";"Glycerolipid metabolism";"Sphingolipid metabolism";"Stachyose degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series"
APLA010437-PA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-611105	"HATs acetylate histones";"Respiratory electron transport"
APLA011440-PA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
APLA001862-PA	3	Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621	"Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism"
APLA001905-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA004542-PA	2	Reactome: R-HSA-1483148;Reactome: R-HSA-1483166	"Synthesis of PG";"Synthesis of PA"
APLA008250-PA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
APLA007205-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA000476-PA	9	MetaCyc: PWY-1042;KEGG: 00010+1.2.1.12;Reactome: R-HSA-70263;MetaCyc: PWY-6901;MetaCyc: PWY-5484;Reactome: R-HSA-70171;KEGG: 00710+1.2.1.12;MetaCyc: PWY-8004;MetaCyc: PWY-7003	"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Carbon fixation in photosynthetic organisms";"Entner-Doudoroff pathway I";"Glycerol degradation to butanol"
APLA008288-PA	2	Reactome: R-HSA-427413;Reactome: R-HSA-3214847	"NoRC negatively regulates rRNA expression";"HATs acetylate histones"
APLA015356-PA	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154;Reactome: R-HSA-445355	"Purine metabolism";"Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction"
APLA007538-PA	5	KEGG: 00052+3.2.1.22;KEGG: 00561+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;MetaCyc: PWY-6527	"Galactose metabolism";"Glycerolipid metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Stachyose degradation"
APLA001857-PA	2	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"COPI-mediated anterograde transport"
APLA005659-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA012828-PA	6	Reactome: R-HSA-8863795;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-8948751;MetaCyc: PWY-7511;Reactome: R-HSA-2173788	"Downregulation of ERBB2 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"Regulation of PTEN stability and activity";"Protein ubiquitination";"Downregulation of TGF-beta receptor signaling"
APLA003133-PA	3	MetaCyc: PWY-7799;MetaCyc: PWY-7800;Reactome: R-HSA-2514859	"Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway";"Inactivation, recovery and regulation of the phototransduction cascade"
APLA005085-PA	8	MetaCyc: PWY-6309;KEGG: 00380+3.5.1.9;KEGG: 00630+3.5.1.9;MetaCyc: PWY-5651;MetaCyc: PWY-7717;MetaCyc: PWY-7765;MetaCyc: PWY-7733;MetaCyc: PWY-7734	"L-tryptophan degradation XI (mammalian, via kynurenine)";"Tryptophan metabolism";"Glyoxylate and dicarboxylate metabolism";"L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde";"3-hydroxy-4-methyl-anthranilate biosynthesis I";"3-hydroxy-4-methyl-anthranilate biosynthesis II";"3-hydroxyquinaldate biosynthesis";"Quinoxaline-2-carboxylate biosynthesis"
APLA001123-PA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
APLA005264-PA	15	Reactome: R-HSA-179409;Reactome: R-HSA-174084;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-141430;Reactome: R-HSA-2467813;Reactome: R-HSA-176407;Reactome: R-HSA-2559582;Reactome: R-HSA-176412;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-69017	"APC-Cdc20 mediated degradation of Nek2A";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Separation of Sister Chromatids";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Senescence-Associated Secretory Phenotype (SASP)";"Phosphorylation of the APC/C";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"CDK-mediated phosphorylation and removal of Cdc6"
APLA007979-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA001974-PA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA012425-PA	8	MetaCyc: PWY-922;KEGG: 00900+1.1.1.34;MetaCyc: PWY-6174;MetaCyc: PWY-7524;MetaCyc: PWY-7391;Reactome: R-HSA-191273;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168	"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Mevalonate pathway II (archaea)";"Mevalonate pathway III (archaea)";"Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)"
APLA007679-PA	9	MetaCyc: PWY-7003;MetaCyc: PWY-8004;KEGG: 00710+1.2.1.12;Reactome: R-HSA-70171;MetaCyc: PWY-5484;Reactome: R-HSA-70263;MetaCyc: PWY-6901;KEGG: 00010+1.2.1.12;MetaCyc: PWY-1042	"Glycerol degradation to butanol";"Entner-Doudoroff pathway I";"Carbon fixation in photosynthetic organisms";"Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)"
APLA004823-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA010507-PA	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
APLA003064-PA	16	Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-1799339	"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane"
APLA013061-PA	1	Reactome: R-HSA-186797	"Signaling by PDGF"
APLA008125-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA002090-PA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
APLA003678-PA	19	Reactome: R-HSA-5686938;Reactome: R-HSA-8856828;Reactome: R-HSA-432142;Reactome: R-HSA-8964038;Reactome: R-HSA-3000480;Reactome: R-HSA-8957275;Reactome: R-HSA-3000484;Reactome: R-HSA-8963888;Reactome: R-HSA-8964046;Reactome: R-HSA-975634;Reactome: R-HSA-8856825;Reactome: R-HSA-8964026;Reactome: R-HSA-3000471;Reactome: R-HSA-8964041;Reactome: R-HSA-8866423;Reactome: R-HSA-202733;Reactome: R-HSA-3000497;Reactome: R-HSA-8963901;Reactome: R-HSA-381426	"Regulation of TLR by endogenous ligand";"Clathrin-mediated endocytosis";"Platelet sensitization by LDL";"LDL clearance";"Scavenging by Class A Receptors";"Post-translational protein phosphorylation";"Scavenging by Class F Receptors";"Chylomicron assembly";"VLDL clearance";"Retinoid metabolism and transport";"Cargo recognition for clathrin-mediated endocytosis";"Chylomicron clearance";"Scavenging by Class B Receptors";"LDL remodeling";"VLDL assembly";"Cell surface interactions at the vascular wall";"Scavenging by Class H Receptors";"Chylomicron remodeling";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
APLA011026-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA000500-PA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
APLA008758-PA	3	Reactome: R-HSA-70268;MetaCyc: PWY-5386;KEGG: 00620+4.4.1.5	"Pyruvate metabolism";"Methylglyoxal degradation I";"Pyruvate metabolism"
APLA009848-PA	15	Reactome: R-HSA-9652282;Reactome: R-HSA-9665233;Reactome: R-HSA-9665250;Reactome: R-HSA-9665244;Reactome: R-HSA-9665247;Reactome: R-HSA-9665246;Reactome: R-HSA-9665251;Reactome: R-HSA-9634285;Reactome: R-HSA-1227986;Reactome: R-HSA-8863795;Reactome: R-HSA-5637810;Reactome: R-HSA-9665245;Reactome: R-HSA-9665249;Reactome: R-HSA-9664565;Reactome: R-HSA-1236382	"Drug-mediated inhibition of ERBB2 signaling";"Resistance of ERBB2 KD mutants to trastuzumab";"Resistance of ERBB2 KD mutants to AEE788";"Resistance of ERBB2 KD mutants to sapitinib";"Resistance of ERBB2 KD mutants to osimertinib";"Resistance of ERBB2 KD mutants to neratinib";"Resistance of ERBB2 KD mutants to lapatinib";"Constitutive Signaling by Overexpressed ERBB2";"Signaling by ERBB2";"Downregulation of ERBB2 signaling";"Constitutive Signaling by EGFRvIII";"Resistance of ERBB2 KD mutants to tesevatinib";"Resistance of ERBB2 KD mutants to afatinib";"Signaling by ERBB2 KD Mutants";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants"
APLA011048-PA	3	Reactome: R-HSA-203615;Reactome: R-HSA-1474151;KEGG: 00790+1.1.1.153	"eNOS activation";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis"
APLA003253-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA001977-PA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
APLA014540-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA008398-PA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
APLA012308-PA	6	KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107	"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism"
APLA012911-PA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72706	"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit"
APLA000663-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA008349-PA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
APLA010016-PA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
APLA001089-PA	4	Reactome: R-HSA-6798695;Reactome: R-HSA-6802952;Reactome: R-HSA-1632852;Reactome: R-HSA-983168	"Neutrophil degranulation";"Signaling by BRAF and RAF fusions";"Macroautophagy";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA006899-PA	32	Reactome: R-HSA-9018519;Reactome: R-HSA-167238;Reactome: R-HSA-167242;Reactome: R-HSA-72165;Reactome: R-HSA-6796648;Reactome: R-HSA-6807505;Reactome: R-HSA-6803529;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-167161;Reactome: R-HSA-168325;Reactome: R-HSA-72203;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167160;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-72163;Reactome: R-HSA-8851708;Reactome: R-HSA-167290	"Estrogen-dependent gene expression";"Pausing and recovery of Tat-mediated HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Minor Pathway";"TP53 Regulates Transcription of DNA Repair Genes";"RNA polymerase II transcribes snRNA genes";"FGFR2 alternative splicing";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"Formation of the Early Elongation Complex";"mRNA Capping";"HIV Transcription Initiation";"Viral Messenger RNA Synthesis";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Splicing - Major Pathway";"Signaling by FGFR2 IIIa TM";"Pausing and recovery of HIV elongation"
APLA008823-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-390471	"Major pathway of rRNA processing in the nucleolus and cytosol";"Association of TriC/CCT with target proteins during biosynthesis"
APLA004642-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA003850-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA005781-PA	3	Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.5	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
APLA001536-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA010134-PA	2	Reactome: R-HSA-196819;KEGG: 00230+4.6.1.1	"Vitamin B1 (thiamin) metabolism";"Purine metabolism"
APLA005358-PA	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
APLA010423-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA010601-PA	15	Reactome: R-HSA-196299;Reactome: R-HSA-5339716;Reactome: R-HSA-195253;Reactome: R-HSA-5467337;Reactome: R-HSA-111465;Reactome: R-HSA-5358749;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-5467333;Reactome: R-HSA-5467348;Reactome: R-HSA-5358752;Reactome: R-HSA-3769402;Reactome: R-HSA-5358747;Reactome: R-HSA-5467340;Reactome: R-HSA-5689896	"Beta-catenin phosphorylation cascade";"Misspliced GSK3beta mutants stabilize beta-catenin";"Degradation of beta-catenin by the destruction complex";"APC truncation mutants have impaired AXIN binding";"Apoptotic cleavage of cellular proteins";"S37 mutants of beta-catenin aren't phosphorylated";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants are not K63 polyubiquitinated";"Truncations of AMER1 destabilize the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Deactivation of the beta-catenin transactivating complex";"S33 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"Ovarian tumor domain proteases"
APLA014309-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA003473-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA006070-PA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
APLA012999-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA001684-PA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
APLA012329-PA	3	KEGG: 00600+3.1.4.12;MetaCyc: PWY-7277;Reactome: R-HSA-1660662	"Sphingolipid metabolism";"Sphingolipid biosynthesis (mammals)";"Glycosphingolipid metabolism"
APLA005222-PA	7	KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
APLA001158-PA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
APLA006903-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA002967-PA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
APLA013969-PA	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
APLA000677-PA	3	MetaCyc: PWY-5067;KEGG: 00500+2.4.1.11;Reactome: R-HSA-3322077	"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Glycogen synthesis"
APLA010172-PA	7	Reactome: R-HSA-68867;Reactome: R-HSA-68689;Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-69205	"Assembly of the pre-replicative complex";"CDC6 association with the ORC:origin complex";"CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"G1/S-Specific Transcription"
APLA008971-PA	1	Reactome: R-HSA-8849175	"Threonine catabolism"
APLA006854-PA	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA003430-PA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
APLA009743-PA	7	MetaCyc: PWY-7456;KEGG: 00520+5.4.2.8;MetaCyc: PWY-7586;MetaCyc: PWY-882;KEGG: 00051+5.4.2.8;Reactome: R-HSA-446205;MetaCyc: PWY-5659	"Beta-(1,4)-mannan degradation";"Amino sugar and nucleotide sugar metabolism";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"L-ascorbate biosynthesis I (L-galactose pathway)";"Fructose and mannose metabolism";"Synthesis of GDP-mannose";"GDP-mannose biosynthesis"
APLA008834-PA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
APLA000630-PA	5	Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-73772	"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape"
APLA014914-PA	2	Reactome: R-HSA-1799339;Reactome: R-HSA-6798695	"SRP-dependent cotranslational protein targeting to membrane";"Neutrophil degranulation"
APLA004700-PA	6	Reactome: R-HSA-381426;Reactome: R-HSA-201722;Reactome: R-HSA-2173796;Reactome: R-HSA-5626467;Reactome: R-HSA-8957275;Reactome: R-HSA-3769402	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Formation of the beta-catenin:TCF transactivating complex";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"RHO GTPases activate IQGAPs";"Post-translational protein phosphorylation";"Deactivation of the beta-catenin transactivating complex"
APLA000605-PA	13	Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-9633012	"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
APLA004503-PA	6	Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-72689	"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits"
APLA007229-PA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
APLA013807-PA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
APLA004200-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA006554-PA	14	MetaCyc: PWY-7039;MetaCyc: PWY-6351;Reactome: R-HSA-112043;Reactome: R-HSA-399997;Reactome: R-HSA-418217;Reactome: R-HSA-500657;MetaCyc: PWY-8052;Reactome: R-HSA-4086398;Reactome: R-HSA-416476;KEGG: 04070+3.1.4.11;Reactome: R-HSA-434316;MetaCyc: PWY-6367;Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11	"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"PLC beta mediated events";"Acetylcholine regulates insulin secretion";"G beta:gamma signalling through PLC beta";"Presynaptic function of Kainate receptors";"2-arachidonoylglycerol biosynthesis";"Ca2+ pathway";"G alpha (q) signalling events";"Phosphatidylinositol signaling system";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"D-myo-inositol-5-phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism"
APLA003637-PA	2	KEGG: 00860+4.99.1.1;Reactome: R-HSA-189451	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis"
APLA004881-PA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
APLA013630-PA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
APLA004629-PA	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
APLA011378-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA008228-PA	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
APLA003713-PA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
APLA001632-PA	3	Reactome: R-HSA-110329;Reactome: R-HSA-110357;Reactome: R-HSA-110328	"Cleavage of the damaged pyrimidine";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
APLA013610-PA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
APLA004582-PA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6	"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism"
APLA010581-PA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
APLA006392-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA000479-PA	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
APLA002301-PA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
APLA002458-PA	13	MetaCyc: PWY-7384;MetaCyc: PWY-6969;MetaCyc: PWY-5538;MetaCyc: PWY-5690;KEGG: 00640+6.2.1.5;Reactome: R-HSA-71403;MetaCyc: PWY-6728;KEGG: 00020+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5537;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-5913	"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"TCA cycle II (plants and fungi)";"Propanoate metabolism";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Citrate cycle (TCA cycle)";"C5-Branched dibasic acid metabolism";"Pyruvate fermentation to acetate V";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Partial TCA cycle (obligate autotrophs)"
APLA007060-PA	5	Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556	"Insulin receptor recycling";"Ion channel transport";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes"
APLA014879-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA002878-PA	27	Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-4570464;Reactome: R-HSA-3301854;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-3232142;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-170822;Reactome: R-HSA-5619107	"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"ISG15 antiviral mechanism";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of RNA binding proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of ubiquitinylation proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"
APLA002641-PA	1	Reactome: R-HSA-2565942	"Regulation of PLK1 Activity at G2/M Transition"
APLA004537-PA	2	MetaCyc: PWY-5386;KEGG: 00620+3.1.2.6	"Methylglyoxal degradation I";"Pyruvate metabolism"
APLA012328-PA	3	KEGG: 00600+3.1.4.12;MetaCyc: PWY-7277;Reactome: R-HSA-1660662	"Sphingolipid metabolism";"Sphingolipid biosynthesis (mammals)";"Glycosphingolipid metabolism"
APLA002292-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA004835-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA001682-PA	5	Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68867	"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Unwinding of DNA";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex"
APLA000905-PA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
APLA006038-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA007731-PA	1	Reactome: R-HSA-380972	"Energy dependent regulation of mTOR by LKB1-AMPK"
APLA006390-PA	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
APLA005604-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA002900-PA	1	Reactome: R-HSA-5689603	"UCH proteinases"
APLA005630-PA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
APLA003383-PA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
APLA014880-PA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
APLA011621-PA	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
APLA007905-PA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA005863-PA	7	Reactome: R-HSA-389957;Reactome: R-HSA-5620922;Reactome: R-HSA-8950505;Reactome: R-HSA-6814122;Reactome: R-HSA-389960;Reactome: R-HSA-390450;Reactome: R-HSA-390471	"Prefoldin mediated transfer of substrate to CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis"
APLA000859-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA001041-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA007221-PA	1	Reactome: R-HSA-204626	"Hypusine synthesis from eIF5A-lysine"
APLA004732-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA014791-PA	7	Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380259	"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes"
APLA003680-PA	11	Reactome: R-HSA-381340;Reactome: R-HSA-6804114;Reactome: R-HSA-3214858;Reactome: R-HSA-400253;Reactome: R-HSA-9018519;Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-1368082;Reactome: R-HSA-400206	"Transcriptional regulation of white adipocyte differentiation";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"RMTs methylate histone arginines";"Circadian Clock";"Estrogen-dependent gene expression";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"RORA activates gene expression";"Regulation of lipid metabolism by PPARalpha"
APLA013644-PA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
APLA008637-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA001589-PA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
APLA014426-PA	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
APLA001796-PA	1	KEGG: 00860+4.4.1.17	"Porphyrin and chlorophyll metabolism"
APLA013736-PA	10	Reactome: R-HSA-611105;Reactome: R-HSA-9627069;Reactome: R-HSA-111459;Reactome: R-HSA-3299685;Reactome: R-HSA-111464;Reactome: R-HSA-5628897;Reactome: R-HSA-111458;Reactome: R-HSA-111463;Reactome: R-HSA-111457;Reactome: R-HSA-2151201	"Respiratory electron transport";"Regulation of the apoptosome activity";"Activation of caspases through apoptosome-mediated cleavage";"Detoxification of Reactive Oxygen Species";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"TP53 Regulates Metabolic Genes";"Formation of apoptosome";"SMAC (DIABLO) binds to IAPs";"Release of apoptotic factors from the mitochondria";"Transcriptional activation of mitochondrial biogenesis"
APLA005357-PA	7	Reactome: R-HSA-5368286;Reactome: R-HSA-936440;Reactome: R-HSA-8934903;Reactome: R-HSA-1632852;Reactome: R-HSA-5205685;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Negative regulators of DDX58/IFIH1 signaling";"Receptor Mediated Mitophagy";"Macroautophagy";"Pink/Parkin Mediated Mitophagy";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA003794-PA	1	MetaCyc: PWY-7379	"Mrna capping II"
APLA002192-PA	6	Reactome: R-HSA-196807;MetaCyc: PWY-5381;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5653;MetaCyc: PWY-7761;KEGG: 00760+6.3.5.1	"Nicotinate metabolism";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism"
APLA004806-PA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
APLA003947-PA	1	Reactome: R-HSA-9640463	"Wax biosynthesis"
APLA009094-PA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
APLA003190-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA013064-PA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
APLA008524-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA005154-PA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA002908-PA	2	Reactome: R-HSA-164843;Reactome: R-HSA-5693571	"2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)"
APLA001630-PA	1	Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis"
APLA000948-PA	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
APLA005153-PA	1	Reactome: R-HSA-8949613	"Cristae formation"
APLA013577-PA	1	Reactome: R-HSA-2142789	"Ubiquinol biosynthesis"
APLA001793-PA	16	Reactome: R-HSA-8866427;Reactome: R-HSA-437239;Reactome: R-HSA-196025;Reactome: R-HSA-8964038;Reactome: R-HSA-8856828;Reactome: R-HSA-164939;Reactome: R-HSA-167590;Reactome: R-HSA-182218;Reactome: R-HSA-190873;Reactome: R-HSA-5140745;Reactome: R-HSA-416993;Reactome: R-HSA-3928665;Reactome: R-HSA-2132295;Reactome: R-HSA-177504;Reactome: R-HSA-5099900;Reactome: R-HSA-8856825	"VLDLR internalisation and degradation";"Recycling pathway of L1";"Formation of annular gap junctions";"LDL clearance";"Clathrin-mediated endocytosis";"Nef mediated downregulation of CD28 cell surface expression";"Nef Mediated CD4 Down-regulation";"Nef Mediated CD8 Down-regulation";"Gap junction degradation";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Trafficking of GluR2-containing AMPA receptors";"EPH-ephrin mediated repulsion of cells";"MHC class II antigen presentation";"Retrograde neurotrophin signalling";"WNT5A-dependent internalization of FZD4";"Cargo recognition for clathrin-mediated endocytosis"
APLA014312-PA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
APLA010198-PA	24	Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-8955332;Reactome: R-HSA-6811436;Reactome: R-HSA-437239;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-9619483;Reactome: R-HSA-5617833;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Carboxyterminal post-translational modifications of tubulin";"COPI-independent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Aggrephagy";"Separation of Sister Chromatids";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"Gap junction assembly";"HCMV Early Events";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Activation of AMPK downstream of NMDARs";"Cilium Assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Kinesins"
APLA009855-PA	3	MetaCyc: PWY-6619;KEGG: 00230+2.7.1.20;Reactome: R-HSA-74217	"Adenine and adenosine salvage VI";"Purine metabolism";"Purine salvage"
APLA002724-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
APLA013817-PA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
APLA004182-PA	6	KEGG: 00380+1.11.1.6;Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;Reactome: R-HSA-6798695;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241	"Tryptophan metabolism";"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Neutrophil degranulation";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import"
APLA006417-PA	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
APLA011073-PA	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
APLA013154-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA011749-PA	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
APLA003047-PA	14	Reactome: R-HSA-9018519;Reactome: R-HSA-8948700;Reactome: R-HSA-426496;Reactome: R-HSA-8986944;Reactome: R-HSA-426486;Reactome: R-HSA-5687128;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-9029569;Reactome: R-HSA-8934593;Reactome: R-HSA-9022692;Reactome: R-HSA-4086398;Reactome: R-HSA-203927;Reactome: R-HSA-8943723	"Estrogen-dependent gene expression";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Post-transcriptional silencing by small RNAs";"Transcriptional Regulation by MECP2";"Small interfering RNA (siRNA) biogenesis";"MAPK6/MAPK4 signaling";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of RUNX1 Expression and Activity";"Regulation of MECP2 expression and activity";"Ca2+ pathway";"MicroRNA (miRNA) biogenesis";"Regulation of PTEN mRNA translation"
APLA004452-PA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
APLA012222-PA	3	KEGG: 00643+3.7.1.2;Reactome: R-HSA-8963684;KEGG: 00350+3.7.1.2	"Styrene degradation";"Tyrosine catabolism";"Tyrosine metabolism"
APLA000956-PA	13	Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-975957	"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA008301-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA002753-PA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
APLA004330-PA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
APLA004193-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA012294-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA014357-PA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
APLA004102-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA002588-PA	1	Reactome: R-HSA-9640463	"Wax biosynthesis"
APLA008291-PA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
APLA012684-PA	2	Reactome: R-HSA-1799339;Reactome: R-HSA-381038	"SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes"
APLA006599-PA	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
APLA001314-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA010076-PA	9	Reactome: R-HSA-9656255;Reactome: R-HSA-9656256;Reactome: R-HSA-9657050;Reactome: R-HSA-110330;Reactome: R-HSA-110328;Reactome: R-HSA-110331;Reactome: R-HSA-5649702;Reactome: R-HSA-110329;Reactome: R-HSA-110357	"Defective OGG1 Substrate Binding";"Defective OGG1 Substrate Processing";"Defective OGG1 Localization";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged purine";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway";"Cleavage of the damaged pyrimidine";"Displacement of DNA glycosylase by APEX1"
APLA001816-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA001840-PA	6	Reactome: R-HSA-162594;Reactome: R-HSA-110362;Reactome: R-HSA-5685939;Reactome: R-HSA-5651801;Reactome: R-HSA-174437;Reactome: R-HSA-69166	"Early Phase of HIV Life Cycle";"POLB-Dependent Long Patch Base Excision Repair";"HDR through MMEJ (alt-NHEJ)";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate from the C-strand";"Removal of the Flap Intermediate"
APLA014065-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA009979-PA	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
APLA013155-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA007864-PA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
APLA003939-PA	18	KEGG: 00020+1.8.1.4;KEGG: 00280+1.8.1.4;Reactome: R-HSA-70895;KEGG: 00380+1.8.1.4;KEGG: 00640+1.8.1.4;Reactome: R-HSA-204174;KEGG: 00260+1.8.1.4;Reactome: R-HSA-5362517;KEGG: 00310+1.8.1.4;Reactome: R-HSA-70268;KEGG: 00620+1.8.1.4;MetaCyc: PWY-5084;MetaCyc: PWY-5046;Reactome: R-HSA-6783984;Reactome: R-HSA-71403;KEGG: 00010+1.8.1.4;Reactome: R-HSA-389661;Reactome: R-HSA-71064	"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism";"Tryptophan metabolism";"Propanoate metabolism";"Regulation of pyruvate dehydrogenase (PDH) complex";"Glycine, serine and threonine metabolism";"Signaling by Retinoic Acid";"Lysine degradation";"Pyruvate metabolism";"Pyruvate metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Glycine degradation";"Citric acid cycle (TCA cycle)";"Glycolysis / Gluconeogenesis";"Glyoxylate metabolism and glycine degradation";"Lysine catabolism"
APLA002453-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA002507-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA001471-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA004744-PA	6	MetaCyc: PWY-1622;KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;MetaCyc: PWY-5484;KEGG: 00010+5.4.2.11;KEGG: 00680+5.4.2.11	"Formaldehyde assimilation I (serine pathway)";"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Methane metabolism"
APLA000291-PA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA008424-PA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
APLA011778-PA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
APLA009139-PA	3	MetaCyc: PWY-6100;Reactome: R-HSA-71262;KEGG: 00310+1.14.11.8	"L-carnitine biosynthesis";"Carnitine synthesis";"Lysine degradation"
APLA005740-PA	4	KEGG: 00230+6.3.5.2;MetaCyc: PWY-7221;Reactome: R-HSA-73817;KEGG: 00983+6.3.5.2	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Drug metabolism - other enzymes"
APLA010889-PA	7	MetaCyc: PWY-4984;MetaCyc: PWY-31;MetaCyc: PWY-6922;KEGG: 00330+3.5.3.1;KEGG: 00220+3.5.3.1;MetaCyc: PWY-46;Reactome: R-HSA-70635	"Urea cycle";"Canavanine degradation";"L-Ndelta-acetylornithine biosynthesis";"Arginine and proline metabolism";"Arginine biosynthesis";"Putrescine biosynthesis III";"Urea cycle"
APLA008495-PA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
APLA003151-PA	6	Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616	"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange"
APLA010508-PA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
APLA015413-PA	1	MetaCyc: PWY-101	"Photosynthesis light reactions"
APLA015323-PA	6	KEGG: 00564+1.1.5.3;MetaCyc: PWY-6952;MetaCyc: PWY-6118;Reactome: R-HSA-1483166;MetaCyc: PWY-4261;Reactome: R-HSA-163560	"Glycerophospholipid metabolism";"Glycerophosphodiester degradation";"Glycerol-3-phosphate shuttle";"Synthesis of PA";"Glycerol degradation I";"Triglyceride catabolism"
APLA012189-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA001413-PA	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
APLA010945-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA001797-PA	1	KEGG: 00860+4.4.1.17	"Porphyrin and chlorophyll metabolism"
APLA014354-PA	1	KEGG: 00970+6.1.1.20	"Aminoacyl-tRNA biosynthesis"
APLA004383-PA	28	Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-389661;Reactome: R-HSA-437239;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;MetaCyc: PWY-7382;Reactome: R-HSA-6811434;Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-8955332;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-983189;KEGG: 00785+2.3.1.181;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-3371497;Reactome: R-HSA-9609736;Reactome: R-HSA-6807878;Reactome: R-HSA-68877;Reactome: R-HSA-5617833;MetaCyc: PWY-6987;Reactome: R-HSA-190840;Reactome: R-HSA-9619483;Reactome: R-HSA-380320;Reactome: R-HSA-2132295	"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Glyoxylate metabolism and glycine degradation";"Recycling pathway of L1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"Lipoate biosynthesis and incorporation IV (yeast)";"COPI-dependent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Carboxyterminal post-translational modifications of tubulin";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Kinesins";"Lipoic acid metabolism";"HCMV Early Events";"Gap junction assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Assembly and cell surface presentation of NMDA receptors";"COPI-mediated anterograde transport";"Mitotic Prometaphase";"Cilium Assembly";"Lipoate biosynthesis and incorporation III (Bacillus)";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Recruitment of NuMA to mitotic centrosomes";"MHC class II antigen presentation"
APLA000968-PA	2	Reactome: R-HSA-382556;Reactome: R-HSA-5678895	"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis"
APLA011554-PA	2	Reactome: R-HSA-392154;Reactome: R-HSA-1222556	"Nitric oxide stimulates guanylate cyclase";"ROS and RNS production in phagocytes"
APLA006190-PA	6	KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107	"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism"
APLA012562-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA013467-PA	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
APLA007086-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA002946-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA001378-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA014549-PA	7	Reactome: R-HSA-499943;KEGG: 00240+2.7.4.14;KEGG: 00230+2.7.4.3;KEGG: 00983+2.7.4.14;MetaCyc: PWY-7176;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219	"Interconversion of nucleotide di- and triphosphates";"Pyrimidine metabolism";"Purine metabolism";"Drug metabolism - other enzymes";"UTP and CTP de novo biosynthesis";"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis"
APLA005888-PA	6	Reactome: R-HSA-2173788;KEGG: 04658+3.1.3.16;Reactome: R-HSA-400253;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-163560	"Downregulation of TGF-beta receptor signaling";"Th1 and Th2 cell differentiation";"Circadian Clock";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Triglyceride catabolism"
APLA015454-PA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
APLA008842-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA006254-PA	14	MetaCyc: PWY-5690;KEGG: 00720+1.3.5.1;MetaCyc: PWY-6969;MetaCyc: PWY-7254;KEGG: 00020+1.3.5.1;Reactome: R-HSA-611105;MetaCyc: PWY-561;MetaCyc: PWY-4302;MetaCyc: PWY-7279;MetaCyc: PWY-6728;Reactome: R-HSA-71403;KEGG: 00650+1.3.5.1;MetaCyc: PWY-3781;KEGG: 00190+1.3.5.1	"TCA cycle II (plants and fungi)";"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle VII (acetate-producers)";"Citrate cycle (TCA cycle)";"Respiratory electron transport";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration III (alternative oxidase pathway)";"Aerobic respiration II (cytochrome c) (yeast)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Butanoate metabolism";"Aerobic respiration I (cytochrome c)";"Oxidative phosphorylation"
APLA002536-PA	6	MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;Reactome: R-HSA-9640463	"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis"
APLA011325-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA014324-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA008186-PA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
APLA005484-PA	7	Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-76061	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
APLA011577-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA005251-PA	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human papillomavirus infection"
APLA009245-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA006178-PA	40	MetaCyc: PWY-6945;MetaCyc: PWY-6583;KEGG: 00410+4.2.1.17;MetaCyc: PWY-7726;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00930+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7094;MetaCyc: PWY-7606;MetaCyc: PWY-7007;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-5789;KEGG: 00360+4.2.1.17;MetaCyc: PWY-7779;KEGG: 00640+4.2.1.17;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00623+1.1.1.35;MetaCyc: PWY-5136;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-7216;MetaCyc: PWY-6883;MetaCyc: PWY-5177;MetaCyc: PWY-1361;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-5138;MetaCyc: PWY-6435;MetaCyc: PWY-7778;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;MetaCyc: PWY-6944;MetaCyc: PWY-7654;MetaCyc: PWY-6863;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00592+4.2.1.17;MetaCyc: PWY-7401;MetaCyc: PWY-5109	"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Pyruvate fermentation to butanol I";"beta-Alanine metabolism";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Benzoate degradation";"Lysine degradation";"Caprolactam degradation";"Limonene and pinene degradation";"Fatty acid elongation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Aminobenzoate degradation";"Fatty acid salvage";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Methyl ketone biosynthesis (engineered)";"Butanoate metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Phenylalanine metabolism";"Methyl tert-butyl ether degradation";"Propanoate metabolism";"Tryptophan metabolism";"Toluene degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"Carbon fixation pathways in prokaryotes";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Pyruvate fermentation to butanol II (engineered)";"Glutaryl-coa degradation";"Benzoyl-coa degradation I (aerobic)";"Fatty acid degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"4-hydroxybenzoate biosynthesis III (plants)";"2-methylpropene degradation";"Valine, leucine and isoleucine degradation";"Spodoptera littoralis pheromone biosynthesis";"Androstenedione degradation";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Pyruvate fermentation to hexanol (engineered)";"Geraniol degradation";"alpha-Linolenic acid metabolism";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Fermentation to 2-methylbutanoate"
APLA008973-PA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
APLA008271-PA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
APLA009729-PA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
APLA007466-PA	5	KEGG: 00603+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00561+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00052+3.2.1.22	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Stachyose degradation";"Glycerolipid metabolism";"Sphingolipid metabolism";"Galactose metabolism"
APLA011405-PA	9	KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"tRNA modification in the nucleus and cytosol";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
APLA012612-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA006770-PA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
APLA013308-PA	19	Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-5628897;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-611105;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-6790901	"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"TP53 Regulates Metabolic Genes";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"Respiratory electron transport";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"rRNA modification in the nucleus and cytosol"
APLA002432-PA	1	Reactome: R-HSA-912446	"Meiotic recombination"
APLA010449-PA	16	KEGG: 00020+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-7384;MetaCyc: PWY-5537;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5749;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-6969;MetaCyc: PWY-5538;KEGG: 00020+6.2.1.4;MetaCyc: PWY-5913;KEGG: 00640+6.2.1.4;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392	"Citrate cycle (TCA cycle)";"Propanoate metabolism";"TCA cycle II (plants and fungi)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Pyruvate fermentation to acetate V";"C5-Branched dibasic acid metabolism";"Itaconate degradation";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II"
APLA002757-PA	2	Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
APLA003280-PA	8	Reactome: R-HSA-9636467;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-167590;Reactome: R-HSA-182218;Reactome: R-HSA-9639288;Reactome: R-HSA-917977	"Blockage of phagosome acidification";"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"Nef Mediated CD4 Down-regulation";"Nef Mediated CD8 Down-regulation";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling"
APLA007136-PA	11	Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-193692;Reactome: R-HSA-2979096;Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-9013700;Reactome: R-HSA-2644606;Reactome: R-HSA-9017802;Reactome: R-HSA-2894862	"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"Regulated proteolysis of p75NTR";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Noncanonical activation of NOTCH3";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
APLA001533-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
APLA014444-PA	13	Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-72689	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits"
APLA001506-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA011608-PA	1	Reactome: R-HSA-5632928	"Defective Mismatch Repair Associated With MSH2"
APLA009093-PA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
APLA014133-PA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
APLA003531-PA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Neutrophil degranulation";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA000004-PA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA007146-PA	3	Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148	"Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
APLA014358-PA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
APLA005176-PA	5	Reactome: R-HSA-3214815;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947	"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
APLA002001-PA	2	Reactome: R-HSA-6802953;Reactome: R-HSA-5658442	"RAS signaling downstream of NF1 loss-of-function variants";"Regulation of RAS by GAPs"
APLA008019-PA	4	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Ion channel transport"
APLA008018-PA	4	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Ion channel transport"
APLA005073-PA	3	KEGG: 00460+3.5.1.1;Reactome: R-HSA-8964208;KEGG: 00250+3.5.1.1	"Cyanoamino acid metabolism";"Phenylalanine metabolism";"Alanine, aspartate and glutamate metabolism"
APLA001517-PA	1	Reactome: R-HSA-198933	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
APLA008430-PA	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
APLA000056-PA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387	"Neutrophil degranulation";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling"
APLA005011-PA	7	Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-177929;Reactome: R-HSA-1442490	"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Signaling by EGFR";"Collagen degradation"
APLA014032-PA	2	Reactome: R-HSA-416476;Reactome: R-HSA-389397	"G alpha (q) signalling events";"Orexin and neuropeptides FF and QRFP bind to their respective receptors"
APLA004218-PA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA007091-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA005449-PA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
APLA009230-PA	6	Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-6791226;Reactome: R-HSA-450604	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA"
APLA007174-PA	1	Reactome: R-HSA-70921	"Histidine catabolism"
APLA013341-PA	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
APLA013968-PA	56	Reactome: R-HSA-180534;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-5607764;Reactome: R-HSA-5610780;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5678895;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-4641257;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-8939902;Reactome: R-HSA-8852276;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050	"Vpu mediated degradation of CD4";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"CLEC7A (Dectin-1) signaling";"Degradation of GLI1 by the proteasome";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Separation of Sister Chromatids";"Neddylation";"Defective CFTR causes cystic fibrosis";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of AXIN";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of RUNX2 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"
APLA013367-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA004072-PA	1	Reactome: R-HSA-525793	"Myogenesis"
APLA003095-PA	5	KEGG: 04070+2.7.7.41;MetaCyc: PWY-5667;MetaCyc: PWY-7817;KEGG: 00564+2.7.7.41;MetaCyc: PWY-5981	"Phosphatidylinositol signaling system";"CDP-diacylglycerol biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III"
APLA007578-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA002693-PA	8	KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"mTOR signaling pathway";"Activation of RAC1";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway"
APLA001795-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA008811-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA010639-PA	2	Reactome: R-HSA-8853659;Reactome: R-HSA-5673001	"RET signaling";"RAF/MAP kinase cascade"
APLA009554-PA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
APLA000749-PA	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
APLA002375-PA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
APLA011282-PA	4	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-77595	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs"
APLA004212-PA	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
APLA015248-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA015189-PA	56	Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-5362768;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-1236974;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-450408;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-69017;Reactome: R-HSA-5658442;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-69481;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-5610780	"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Degradation of AXIN";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RAS by GAPs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Defective CFTR causes cystic fibrosis";"Neddylation";"Separation of Sister Chromatids";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"G2/M Checkpoints";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of GLI1 by the proteasome"
APLA006227-PA	16	Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764	"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination"
APLA002271-PA	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
APLA006672-PA	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
APLA010020-PA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
APLA005913-PA	5	Reactome: R-HSA-2022857;KEGG: 00531+3.1.6.14;Reactome: R-HSA-6798695;Reactome: R-HSA-2206305;Reactome: R-HSA-432720	"Keratan sulfate degradation";"Glycosaminoglycan degradation";"Neutrophil degranulation";"MPS IIID - Sanfilippo syndrome D";"Lysosome Vesicle Biogenesis"
APLA001445-PA	5	Reactome: R-HSA-1660499;KEGG: 00562+3.1.3.36;Reactome: R-HSA-8856828;MetaCyc: PWY-6368;KEGG: 04070+3.1.3.36	"Synthesis of PIPs at the plasma membrane";"Inositol phosphate metabolism";"Clathrin-mediated endocytosis";"3-phosphoinositide degradation";"Phosphatidylinositol signaling system"
APLA003700-PA	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
APLA012775-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA002235-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA002298-PA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA005945-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA010632-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA012546-PA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
APLA000226-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA000821-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA003163-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA008588-PA	16	Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane"
APLA000488-PA	13	Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-975956	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
APLA014004-PA	2	Reactome: R-HSA-171319;Reactome: R-HSA-6790901	"Telomere Extension By Telomerase";"rRNA modification in the nucleus and cytosol"
APLA011023-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA007093-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA014520-PA	40	Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-5578749;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-6803529;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-72203;Reactome: R-HSA-167161;Reactome: R-HSA-168325;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-6782135;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-5601884;Reactome: R-HSA-77075;Reactome: R-HSA-167290;Reactome: R-HSA-8851708;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-72163;Reactome: R-HSA-203927;Reactome: R-HSA-167160;Reactome: R-HSA-112382;Reactome: R-HSA-9018519;Reactome: R-HSA-167238;Reactome: R-HSA-167242;Reactome: R-HSA-72165;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-5617472;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648	"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Transcriptional regulation by small RNAs";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"FGFR2 alternative splicing";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA";"HIV Transcription Initiation";"Viral Messenger RNA Synthesis";"mRNA Capping";"Formation of the Early Elongation Complex";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Dual incision in TC-NER";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Pausing and recovery of HIV elongation";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"mRNA Splicing - Major Pathway";"MicroRNA (miRNA) biogenesis";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of RNA Pol II elongation complex";"Estrogen-dependent gene expression";"Pausing and recovery of Tat-mediated HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Minor Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes"
APLA005568-PA	1	Reactome: R-HSA-446193	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
APLA001716-PA	5	Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-72187	"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing"
APLA003770-PA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957	"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
APLA005120-PA	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
APLA006673-PA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
APLA014772-PA	6	Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-68877	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase"
APLA010852-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA005033-PA	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.15	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
APLA015063-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA009953-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA006556-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA003892-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA002297-PA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA010301-PA	8	Reactome: R-HSA-6798695;Reactome: R-HSA-8943724;Reactome: R-HSA-166208;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852	"Neutrophil degranulation";"Regulation of PTEN gene transcription";"mTORC1-mediated signalling";"mTOR signalling";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy"
APLA008653-PA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
APLA014452-PA	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
APLA001762-PA	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
APLA004208-PA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
APLA009113-PA	8	Reactome: R-HSA-432040;Reactome: R-HSA-381676;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-983231;Reactome: R-HSA-442720;Reactome: R-HSA-180024;Reactome: R-HSA-164378	"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Hedgehog 'off' state";"PKA activation";"Factors involved in megakaryocyte development and platelet production";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"DARPP-32 events";"PKA activation in glucagon signalling"
APLA013381-PA	1	Reactome: R-HSA-480985	"Synthesis of dolichyl-phosphate-glucose"
APLA007577-PA	2	Reactome: R-HSA-6804758;Reactome: R-HSA-3214847	"Regulation of TP53 Activity through Acetylation";"HATs acetylate histones"
APLA009512-PA	7	KEGG: 00030+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11;Reactome: R-HSA-70263;KEGG: 00051+3.1.3.11;KEGG: 00010+3.1.3.11;MetaCyc: PWY-5484	"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"Methane metabolism";"Gluconeogenesis";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)"
APLA014783-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA003981-PA	3	Reactome: R-HSA-5423646;KEGG: 00220+3.5.1.14;Reactome: R-HSA-5579007	"Aflatoxin activation and detoxification";"Arginine biosynthesis";"Defective ACY1 causes encephalopathy"
APLA003546-PA	6	MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14;Reactome: R-HSA-156842;MetaCyc: PWY-6855;MetaCyc: PWY-7822;Reactome: R-HSA-189085	"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Eukaryotic Translation Elongation";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Digestion of dietary carbohydrate"
APLA013645-PA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
APLA003983-PA	3	Reactome: R-HSA-192456;MetaCyc: PWY-6857;KEGG: 00561+3.1.1.3	"Digestion of dietary lipid";"Retinol biosynthesis";"Glycerolipid metabolism"
APLA001272-PA	5	MetaCyc: PWY-5532;KEGG: 00983+2.4.2.3;Reactome: R-HSA-73614;KEGG: 00240+2.4.2.3;Reactome: R-HSA-73621	"Nucleoside and nucleotide degradation (archaea)";"Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism";"Pyrimidine catabolism"
APLA004611-PA	6	Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385	"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
APLA011740-PA	6	KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107	"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism"
APLA014264-PA	4	Reactome: R-HSA-5205685;Reactome: R-HSA-1632852;Reactome: R-HSA-8934903;Reactome: R-HSA-936440	"Pink/Parkin Mediated Mitophagy";"Macroautophagy";"Receptor Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling"
APLA006341-PA	6	Reactome: R-HSA-3299685;Reactome: R-HSA-6798695;Reactome: R-HSA-9615017;KEGG: 00380+1.11.1.6;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241	"Detoxification of Reactive Oxygen Species";"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Tryptophan metabolism";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import"
APLA014332-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA010856-PA	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
APLA000540-PA	6	MetaCyc: PWY-7782;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Plasmalogen biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
APLA009900-PA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
APLA007851-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA005258-PA	22	MetaCyc: PWY-7592;MetaCyc: PWY-7601;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7602;MetaCyc: PWY-7726;MetaCyc: PWY-6598;MetaCyc: PWY-7053;MetaCyc: PWY-5353;MetaCyc: PWY-7724;MetaCyc: PWY-7035;MetaCyc: PWY-7728;MetaCyc: PWY-6958;MetaCyc: PWY-7606;MetaCyc: PWY-5080;MetaCyc: PWY-7727;KEGG: 00062+4.2.1.134;Reactome: R-HSA-75876;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7619;MetaCyc: PWY-7049	"Arachidonate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Sciadonate biosynthesis";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)"
APLA004904-PA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
APLA012690-PA	1	Reactome: R-HSA-5368286	"Mitochondrial translation initiation"
APLA002322-PA	2	Reactome: R-HSA-375280;Reactome: R-HSA-416476	"Amine ligand-binding receptors";"G alpha (q) signalling events"
APLA007924-PA	3	KEGG: 00860+1.3.3.3;Reactome: R-HSA-189451;MetaCyc: PWY-7159	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"
APLA005633-PA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
APLA003859-PA	8	KEGG: 00270+2.5.1.16;Reactome: R-HSA-351202;MetaCyc: PWY-5194;KEGG: 00330+2.5.1.16;KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107;MetaCyc: PWY-5196;MetaCyc: PWY-7377;KEGG: 00480+2.5.1.16	"Cysteine and methionine metabolism";"Metabolism of polyamines";"Siroheme biosynthesis";"Arginine and proline metabolism";"Porphyrin and chlorophyll metabolism";"Factor 430 biosynthesis";"Cob(ii)yrinate a,c-diamide biosynthesis I (early cobalt insertion)";"Glutathione metabolism"
APLA010562-PA	3	Reactome: R-HSA-2559580;Reactome: R-HSA-8939243;Reactome: R-HSA-8943724	"Oxidative Stress Induced Senescence";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Regulation of PTEN gene transcription"
APLA009951-PA	3	Reactome: R-HSA-3214847;Reactome: R-HSA-1799339;Reactome: R-HSA-446203	"HATs acetylate histones";"SRP-dependent cotranslational protein targeting to membrane";"Asparagine N-linked glycosylation"
APLA014622-PA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
APLA008748-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA011824-PA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
APLA012545-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA004506-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA004190-PA	3	MetaCyc: PWY-7174;MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism"
APLA005626-PA	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
APLA004147-PA	14	MetaCyc: PWY-5667;MetaCyc: PWY-7411;MetaCyc: PWY-8055;MetaCyc: PWY-7417;MetaCyc: PWY-6453;MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-8053;Reactome: R-HSA-1483166;KEGG: 00561+2.3.1.51;KEGG: 00564+2.3.1.51;MetaCyc: PWY-5981;MetaCyc: PWY-7587;MetaCyc: PWY-8051	"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Palmitoyl ethanolamide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Stigma estolide biosynthesis";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II";"Synthesis of PA";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis I"
APLA003120-PA	4	MetaCyc: PWY-5381;Reactome: R-HSA-197264;Reactome: R-HSA-6798695;KEGG: 00760+6.3.4.21	"Pyridine nucleotide cycling (plants)";"Nicotinamide salvaging";"Neutrophil degranulation";"Nicotinate and nicotinamide metabolism"
APLA014016-PA	56	Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5658442;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-69017;Reactome: R-HSA-450408;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-5362768;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-69481;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-8939902;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8852276;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-180585;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091	"Defective CFTR causes cystic fibrosis";"Neddylation";"Separation of Sister Chromatids";"Regulation of RAS by GAPs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"CDK-mediated phosphorylation and removal of Cdc6";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"G2/M Checkpoints";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX2 expression and activity";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"UCH proteinases";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vif-mediated degradation of APOBEC3G";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells"
APLA011617-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA010436-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA001305-PA	7	MetaCyc: PWY-7184;MetaCyc: PWY-7198;KEGG: 00230+3.6.1.15;MetaCyc: PWY-7210;KEGG: 00730+3.6.1.15;MetaCyc: PWY-6545;MetaCyc: PWY-7185	"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Purine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Thiamine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"UTP and CTP dephosphorylation I"
APLA012691-PA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
APLA010587-PA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
APLA014467-PA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-1663150	"Glycosphingolipid metabolism";"The activation of arylsulfatases"
APLA005077-PA	4	Reactome: R-HSA-432720;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6811440	"Lysosome Vesicle Biogenesis";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network"
APLA006809-PA	8	KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6791226	"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA005391-PA	3	MetaCyc: PWY-7221;Reactome: R-HSA-420029;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Tight junction interactions";"Purine metabolism"
APLA008563-PA	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
APLA015266-PA	4	MetaCyc: PWY-7382;Reactome: R-HSA-389661;MetaCyc: PWY-6987;KEGG: 00785+2.8.1.8	"Lipoate biosynthesis and incorporation IV (yeast)";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism"
APLA007536-PA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
APLA011412-PA	4	Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394	"Neddylation";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER"
APLA013627-PA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
APLA006632-PA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
APLA009248-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
APLA000926-PA	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
APLA009662-PA	10	Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-912446;Reactome: R-HSA-5693616;Reactome: R-HSA-5685938	"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Meiotic recombination";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Single Strand Annealing (SSA)"
APLA007661-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA010655-PA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
APLA000572-PA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
APLA001794-PA	3	Reactome: R-HSA-192456;MetaCyc: PWY-6857;KEGG: 00561+3.1.1.3	"Digestion of dietary lipid";"Retinol biosynthesis";"Glycerolipid metabolism"
APLA002558-PA	4	KEGG: 00230+2.7.4.8;Reactome: R-HSA-499943;Reactome: R-HSA-2161541;MetaCyc: PWY-7221	"Purine metabolism";"Interconversion of nucleotide di- and triphosphates";"Abacavir metabolism";"Guanosine ribonucleotides de novo biosynthesis"
APLA005677-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA007048-PA	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
APLA008659-PA	8	Reactome: R-HSA-69166;Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-69091;Reactome: R-HSA-68962;Reactome: R-HSA-174430;Reactome: R-HSA-174411;Reactome: R-HSA-69183	"Removal of the Flap Intermediate";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"Polymerase switching";"Activation of the pre-replicative complex";"Telomere C-strand synthesis initiation";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand"
APLA008323-PA	3	Reactome: R-HSA-2024096;Reactome: R-HSA-2024101;Reactome: R-HSA-2206296	"HS-GAG degradation";"CS/DS degradation";"MPS II - Hunter syndrome"
APLA004891-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA004312-PA	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
APLA009711-PA	7	Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
APLA013844-PA	56	Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-180585;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-5632684;Reactome: R-HSA-195253;Reactome: R-HSA-174184;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-450408;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-1236974;Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2467813;Reactome: R-HSA-5658442;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69017;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-5610780;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178	"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Degradation of AXIN";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vif-mediated degradation of APOBEC3G";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Hedgehog 'on' state";"Degradation of beta-catenin by the destruction complex";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"ER-Phagosome pathway";"Defective CFTR causes cystic fibrosis";"Neddylation";"Separation of Sister Chromatids";"Regulation of RAS by GAPs";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"Degradation of GLI1 by the proteasome";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
APLA001165-PA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
APLA007915-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA006682-PA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
APLA002378-PA	6	MetaCyc: PWY-6906;KEGG: 00520+5.4.2.10;KEGG: 00520+5.4.2.3;Reactome: R-HSA-446210;MetaCyc: PWY-5514;MetaCyc: PWY-6749	"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"UDP-N-acetyl-D-galactosamine biosynthesis II";"CMP-legionaminate biosynthesis I"
APLA002696-PA	1	Reactome: R-HSA-5676934	"Protein repair"
APLA011085-PA	9	Reactome: R-HSA-2024096;Reactome: R-HSA-3656237;Reactome: R-HSA-975634;Reactome: R-HSA-4420332;Reactome: R-HSA-3560783;Reactome: R-HSA-3656253;Reactome: R-HSA-2022928;Reactome: R-HSA-1971475;Reactome: R-HSA-3560801	"HS-GAG degradation";"Defective EXT2 causes exostoses 2";"Retinoid metabolism and transport";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective B4GALT7 causes EDS, progeroid type";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"HS-GAG biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GAT3 causes JDSSDHD"
APLA003173-PA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
APLA005605-PA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
APLA001296-PA	6	MetaCyc: PWY-622;MetaCyc: PWY-7900;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.18;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085	"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
APLA009926-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA002692-PA	15	Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;MetaCyc: PWY-5744;Reactome: R-HSA-166208;MetaCyc: PWY-7117;KEGG: 00910+4.2.1.1;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;MetaCyc: PWY-241;MetaCyc: PWY-6142;MetaCyc: PWY-5743;MetaCyc: PWY-5789;Reactome: R-HSA-8943724;MetaCyc: PWY-7115	"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Glyoxylate assimilation";"mTORC1-mediated signalling";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Nitrogen metabolism";"mTOR signalling";"Amino acids regulate mTORC1";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Regulation of PTEN gene transcription";"C4 photosynthetic carbon assimilation cycle, NAD-ME type"
APLA005321-PA	11	Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167152;Reactome: R-HSA-167290	"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation"
APLA002086-PA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72649	"Selenocysteine synthesis";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation"
APLA002153-PA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
APLA005565-PA	27	Reactome: R-HSA-5619107;Reactome: R-HSA-170822;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-3232142;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-5578749;Reactome: R-HSA-4570464;Reactome: R-HSA-3301854;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-4551638;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-6784531;Reactome: R-HSA-1169408;Reactome: R-HSA-180910;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214	"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"SUMOylation of ubiquitinylation proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of DNA replication proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Transcriptional regulation by small RNAs";"SUMOylation of RNA binding proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"tRNA processing in the nucleus";"ISG15 antiviral mechanism";"Vpr-mediated nuclear import of PICs";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins"
APLA000123-PA	1	Reactome: R-HSA-8876725	"Protein methylation"
APLA000784-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA011523-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA008204-PA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
APLA012204-PA	1	Reactome: R-HSA-8963889	"Assembly of active LPL and LIPC lipase complexes"
APLA004432-PA	5	KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341;Reactome: R-HSA-2871796;Reactome: R-HSA-2559580;Reactome: R-HSA-450321	"mTOR signaling pathway";"Activation of the AP-1 family of transcription factors";"FCERI mediated MAPK activation";"Oxidative Stress Induced Senescence";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"
APLA002665-PA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
APLA003749-PA	2	Reactome: R-HSA-6783984;Reactome: R-HSA-389661	"Glycine degradation";"Glyoxylate metabolism and glycine degradation"
APLA006680-PA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
APLA006618-PA	13	Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane"
APLA000215-PA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-8873719	"RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation"
APLA001975-PA	14	KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051;KEGG: 00591+3.1.1.4;Reactome: R-HSA-975634;MetaCyc: PWY-7409;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8053;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-7783;MetaCyc: PWY-7417;MetaCyc: PWY-6803;MetaCyc: PWY-7416	"Arachidonic acid metabolism";"Anandamide biosynthesis I";"Linoleic acid metabolism";"Retinoid metabolism and transport";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis II";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylcholine, yeast)"
APLA011106-PA	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
APLA006662-PA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
APLA015182-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA012877-PA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
APLA013282-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA007863-PA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
APLA007521-PA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
APLA006000-PA	1	Reactome: R-HSA-446203	"Asparagine N-linked glycosylation"
APLA007155-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA003881-PA	1	MetaCyc: PWY-6771	"Rhamnogalacturonan type I degradation II (bacteria)"
APLA000176-PA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
APLA006388-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA012215-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA008490-PA	25	Reactome: R-HSA-8935964;Reactome: R-HSA-8941858;Reactome: R-HSA-8934593;Reactome: R-HSA-8941332;Reactome: R-HSA-8940973;Reactome: R-HSA-8939246;Reactome: R-HSA-9616222;Reactome: R-HSA-8939242;Reactome: R-HSA-8939256;Reactome: R-HSA-8949275;Reactome: R-HSA-8939236;Reactome: R-HSA-8939245;Reactome: R-HSA-8931987;Reactome: R-HSA-8941326;Reactome: R-HSA-8941333;Reactome: R-HSA-8877330;Reactome: R-HSA-8878166;Reactome: R-HSA-8939902;Reactome: R-HSA-8941284;Reactome: R-HSA-8951911;Reactome: R-HSA-8951936;Reactome: R-HSA-8939243;Reactome: R-HSA-8939247;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519	"RUNX1 regulates expression of components of tight junctions";"Regulation of RUNX3 expression and activity";"Regulation of RUNX1 Expression and Activity";"RUNX2 regulates genes involved in cell migration";"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX1 regulates transcription of genes involved in WNT signaling";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX2 regulates bone development";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"Transcriptional regulation by RUNX2";"Regulation of RUNX2 expression and activity";"RUNX2 regulates chondrocyte maturation";"RUNX3 regulates RUNX1-mediated transcription";"RUNX3 regulates p14-ARF";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression"
APLA001076-PA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
APLA000482-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA011846-PA	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
APLA011336-PA	7	KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
APLA000440-PA	3	Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621	"Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism"
APLA014833-PA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
APLA009184-PA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
APLA006969-PA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
APLA005323-PA	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
APLA007219-PA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
APLA008157-PA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
APLA008966-PA	4	Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism"
APLA009947-PA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA011347-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA001289-PA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
APLA001617-PA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
APLA012470-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA005278-PA	3	Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation"
APLA008278-PA	4	Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
APLA001691-PA	26	Reactome: R-HSA-5651801;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-174437;Reactome: R-HSA-5358565;Reactome: R-HSA-5655862;Reactome: R-HSA-8866654;Reactome: R-HSA-69205;Reactome: R-HSA-4615885;Reactome: R-HSA-174414;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-5696400;Reactome: R-HSA-174411;Reactome: R-HSA-69183;Reactome: R-HSA-110312;Reactome: R-HSA-1362277;Reactome: R-HSA-69091;Reactome: R-HSA-5358606;Reactome: R-HSA-110320;Reactome: R-HSA-6782135;Reactome: R-HSA-174417;Reactome: R-HSA-69166;Reactome: R-HSA-6782210;Reactome: R-HSA-6804114;Reactome: R-HSA-5656121	"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate from the C-strand";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion synthesis by POLK";"E3 ubiquitin ligases ubiquitinate target proteins";"G1/S-Specific Transcription";"SUMOylation of DNA replication proteins";"Processive synthesis on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"Dual Incision in GG-NER";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Translesion synthesis by REV1";"Transcription of E2F targets under negative control by DREAM complex";"Polymerase switching";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Translesion Synthesis by POLH";"Dual incision in TC-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Removal of the Flap Intermediate";"Gap-filling DNA repair synthesis and ligation in TC-NER";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Translesion synthesis by POLI"
APLA000447-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA010435-PA	1	Reactome: R-HSA-532668	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
APLA006946-PA	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
APLA014539-PA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
APLA009465-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA011452-PA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
APLA011128-PA	2	Reactome: R-HSA-1299308;Reactome: R-HSA-5576886	"Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)";"Phase 4 - resting membrane potential"
APLA001842-PA	1	Reactome: R-HSA-2468052	"Establishment of Sister Chromatid Cohesion"
APLA005367-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA004588-PA	6	Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6;KEGG: 00380+1.11.1.6;Reactome: R-HSA-6798695;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685	"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism";"Tryptophan metabolism";"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species"
APLA002907-PA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
APLA014588-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA014162-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA010885-PA	5	Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-983170;Reactome: R-HSA-2132295;Reactome: R-HSA-204005	"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"MHC class II antigen presentation";"COPII-mediated vesicle transport"
APLA015241-PA	11	Reactome: R-HSA-380270;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-2132295;Reactome: R-HSA-380259;Reactome: R-HSA-6807878	"Recruitment of mitotic centrosome proteins and complexes";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"MHC class II antigen presentation";"Loss of Nlp from mitotic centrosomes";"COPI-mediated anterograde transport"
APLA011850-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA011430-PA	2	Reactome: R-HSA-8854214;Reactome: R-HSA-8873719	"TBC/RABGAPs";"RAB geranylgeranylation"
APLA014160-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA001094-PA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA000736-PA	8	KEGG: 00270+1.1.1.27;KEGG: 00640+1.1.1.27;KEGG: 00620+1.1.1.27;MetaCyc: PWY-8086;MetaCyc: PWY-6901;KEGG: 00010+1.1.1.27;MetaCyc: PWY-5481;Reactome: R-HSA-70268	"Cysteine and methionine metabolism";"Propanoate metabolism";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis";"Pyruvate fermentation to (S)-lactate";"Pyruvate metabolism"
APLA010513-PA	5	Reactome: R-HSA-1442490;Reactome: R-HSA-2022090;Reactome: R-HSA-1679131;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295	"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures";"Trafficking and processing of endosomal TLR";"Neutrophil degranulation";"MHC class II antigen presentation"
APLA012114-PA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1660662	"Neutrophil degranulation";"Glycosphingolipid metabolism"
APLA002123-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA004778-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA003820-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA007496-PA	7	Reactome: R-HSA-5674400;Reactome: R-HSA-8854214;Reactome: R-HSA-165181;Reactome: R-HSA-198323;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-380972	"Constitutive Signaling by AKT1 E17K in Cancer";"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB";"AKT phosphorylates targets in the cytosol";"Macroautophagy";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK"
APLA001663-PA	8	Reactome: R-HSA-68949;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-68689;Reactome: R-HSA-176187;Reactome: R-HSA-68616	"Orc1 removal from chromatin";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication"
APLA001541-PA	17	Reactome: R-HSA-6796648;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-6783310;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693607;Reactome: R-HSA-176187;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-1221632;Reactome: R-HSA-3371453;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"TP53 Regulates Transcription of DNA Repair Genes";"Relaxin signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Fanconi Anemia Pathway";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Thermogenesis";"mTOR signaling pathway";"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Meiotic synapsis";"Regulation of HSF1-mediated heat shock response";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
APLA002551-PA	25	Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-8955332;Reactome: R-HSA-6811436;Reactome: R-HSA-437239;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-3371497;Reactome: R-HSA-9609736;Reactome: R-HSA-9619483;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-380270;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Carboxyterminal post-translational modifications of tubulin";"COPI-independent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Separation of Sister Chromatids";"Aggrephagy";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"HCMV Early Events";"Gap junction assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Assembly and cell surface presentation of NMDA receptors";"Activation of AMPK downstream of NMDARs";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Cilium Assembly";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Recruitment of mitotic centrosome proteins and complexes";"Kinesins"
APLA005948-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA002461-PA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
APLA006858-PA	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
APLA000054-PA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
APLA006559-PA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
APLA004737-PA	5	Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-159231;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA Derived from an Intronless Transcript";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
APLA013151-PA	17	Reactome: R-HSA-5656169;Reactome: R-HSA-5696400;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-5358606;Reactome: R-HSA-69091;Reactome: R-HSA-174417;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-69166;Reactome: R-HSA-5651801;Reactome: R-HSA-174437;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-5358565;Reactome: R-HSA-174414;Reactome: R-HSA-5696397	"Termination of translesion DNA synthesis";"Dual Incision in GG-NER";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Polymerase switching";"Telomere C-strand (Lagging Strand) Synthesis";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Removal of the Flap Intermediate";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate from the C-strand";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Processive synthesis on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in GG-NER"
APLA005010-PA	3	Reactome: R-HSA-611105;Reactome: R-HSA-6799198;Reactome: R-HSA-1268020	"Respiratory electron transport";"Complex I biogenesis";"Mitochondrial protein import"
APLA001295-PA	6	MetaCyc: PWY-7900;MetaCyc: PWY-622;Reactome: R-HSA-189085;KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.18	"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch biosynthesis";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism"
APLA003817-PA	10	MetaCyc: PWY-8004;KEGG: 00710+2.7.2.3;MetaCyc: PWY-7003;Reactome: R-HSA-70171;MetaCyc: PWY-5484;MetaCyc: PWY-6886;KEGG: 00010+2.7.2.3;Reactome: R-HSA-70263;MetaCyc: PWY-6901;MetaCyc: PWY-1042	"Entner-Doudoroff pathway I";"Carbon fixation in photosynthetic organisms";"Glycerol degradation to butanol";"Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Glycolysis IV (plant cytosol)"
APLA008215-PA	7	Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
APLA004172-PA	6	KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00380+1.11.1.6;Reactome: R-HSA-3299685;Reactome: R-HSA-6798695;Reactome: R-HSA-9615017	"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import";"Tryptophan metabolism";"Detoxification of Reactive Oxygen Species";"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
APLA002005-PA	1	Reactome: R-HSA-191859	"snRNP Assembly"
APLA004375-PA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
APLA004223-PA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
APLA012906-PA	5	KEGG: 00250+6.3.5.4;Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;Reactome: R-HSA-9648895;Reactome: R-HSA-380994	"Alanine, aspartate and glutamate metabolism";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"Response of EIF2AK1 (HRI) to heme deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress"
APLA003048-PA	12	Reactome: R-HSA-167200;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-75955;Reactome: R-HSA-6804756;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-6796648	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Regulation of TP53 Activity through Phosphorylation";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes"
APLA011360-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA007468-PA	5	MetaCyc: PWY-6527;KEGG: 00603+3.2.1.22;KEGG: 00052+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22	"Stachyose degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Galactose metabolism";"Sphingolipid metabolism";"Glycerolipid metabolism"
APLA009102-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA003736-PA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
APLA013330-PA	14	MetaCyc: PWY-3781;KEGG: 00190+1.3.5.1;MetaCyc: PWY-5690;MetaCyc: PWY-6969;KEGG: 00720+1.3.5.1;MetaCyc: PWY-7254;KEGG: 00020+1.3.5.1;Reactome: R-HSA-611105;MetaCyc: PWY-7279;MetaCyc: PWY-4302;MetaCyc: PWY-561;MetaCyc: PWY-6728;Reactome: R-HSA-71403;KEGG: 00650+1.3.5.1	"Aerobic respiration I (cytochrome c)";"Oxidative phosphorylation";"TCA cycle II (plants and fungi)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"TCA cycle VII (acetate-producers)";"Citrate cycle (TCA cycle)";"Respiratory electron transport";"Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Butanoate metabolism"
APLA013738-PA	17	MetaCyc: PWY-7179;Reactome: R-HSA-6798695;MetaCyc: PWY-6620;KEGG: 00240+2.4.2.1;MetaCyc: PWY-7179-1;Reactome: R-HSA-74217;Reactome: R-HSA-74259;MetaCyc: PWY-6609;MetaCyc: PWY-6611;MetaCyc: PWY-6627;MetaCyc: PWY-5532;MetaCyc: PWY-5695;MetaCyc: PWY-6608;KEGG: 00230+2.4.2.1;MetaCyc: PWY-6644;MetaCyc: PWY-4202;KEGG: 00760+2.4.2.1	"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Guanine and guanosine salvage";"Pyrimidine metabolism";"Purine deoxyribonucleosides degradation II";"Purine salvage";"Purine catabolism";"Adenine and adenosine salvage III";"Adenine and adenosine salvage V";"Salinosporamide A biosynthesis";"Nucleoside and nucleotide degradation (archaea)";"Inosine 5'-phosphate degradation";"Guanosine nucleotides degradation III";"Purine metabolism";"Fluoroacetate and fluorothreonine biosynthesis";"Arsenate detoxification I (mammalian)";"Nicotinate and nicotinamide metabolism"
APLA009176-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA007914-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA013496-PA	17	MetaCyc: PWY-5789;KEGG: 00254+6.4.1.2;MetaCyc: PWY-5743;KEGG: 00061+6.4.1.2;KEGG: 00620+6.4.1.2;Reactome: R-HSA-196780;KEGG: 00720+6.4.1.2;MetaCyc: PWY-6679;Reactome: R-HSA-200425;Reactome: R-HSA-3371599;MetaCyc: PWY-6722;KEGG: 00640+6.4.1.2;Reactome: R-HSA-163765;MetaCyc: PWY-5966-1;Reactome: R-HSA-2426168;MetaCyc: PWY-4381;MetaCyc: PWY-5744	"3-hydroxypropanoate/4-hydroxybutanate cycle";"Aflatoxin biosynthesis";"3-hydroxypropanoate cycle";"Fatty acid biosynthesis";"Pyruvate metabolism";"Biotin transport and metabolism";"Carbon fixation pathways in prokaryotes";"Jadomycin biosynthesis";"Carnitine metabolism";"Defective HLCS causes multiple carboxylase deficiency";"Candicidin biosynthesis";"Propanoate metabolism";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Glyoxylate assimilation"
APLA005632-PA	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
APLA009552-PA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA005929-PA	6	Reactome: R-HSA-912446;Reactome: R-HSA-5545483;Reactome: R-HSA-5358606;Reactome: R-HSA-6796648;Reactome: R-HSA-5358565;Reactome: R-HSA-5632987	"Meiotic recombination";"Defective Mismatch Repair Associated With MLH1";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"TP53 Regulates Transcription of DNA Repair Genes";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With PMS2"
APLA010399-PA	5	Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-389357;Reactome: R-HSA-1257604	"Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling"
APLA000323-PA	11	MetaCyc: PWY-6549;MetaCyc: PWY-6963;KEGG: 00220+6.3.1.2;MetaCyc: PWY-5675;Reactome: R-HSA-210455;MetaCyc: PWY-381;KEGG: 00910+6.3.1.2;KEGG: 00250+6.3.1.2;KEGG: 00630+6.3.1.2;MetaCyc: PWY-6964;Reactome: R-HSA-8964539	"L-glutamine biosynthesis III";"Ammonia assimilation cycle I";"Arginine biosynthesis";"Nitrate reduction V (assimilatory)";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Nitrate reduction II (assimilatory)";"Nitrogen metabolism";"Alanine, aspartate and glutamate metabolism";"Glyoxylate and dicarboxylate metabolism";"Ammonia assimilation cycle II";"Glutamate and glutamine metabolism"
APLA015417-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA012979-PA	5	KEGG: 00514+2.4.1.109;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7921;MetaCyc: PWY-7979	"Other types of O-glycan biosynthesis";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation III (mammals, core M3)"
APLA001576-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA012317-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA007966-PA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
APLA012134-PA	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-6807878	"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"COPI-mediated anterograde transport"
APLA003953-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA003196-PA	6	Reactome: R-HSA-6781827;MetaCyc: PWY-7511;Reactome: R-HSA-6781823;Reactome: R-HSA-72163;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Protein ubiquitination";"Formation of TC-NER Pre-Incision Complex";"mRNA Splicing - Major Pathway";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER"
APLA014542-PA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
APLA008923-PA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
APLA011607-PA	1	Reactome: R-HSA-8964572	"Lipid particle organization"
APLA014128-PA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
APLA008908-PA	4	KEGG: 00270+2.5.1.6;MetaCyc: PWY-5912;Reactome: R-HSA-156581;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"2'-deoxymugineic acid phytosiderophore biosynthesis";"Methylation";"S-adenosyl-L-methionine cycle II"
APLA013908-PA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
APLA009724-PA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
APLA008747-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA000967-PA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA010314-PA	3	MetaCyc: PWY-6829;Reactome: R-HSA-6782315;MetaCyc: PWY-7888	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol";"Trna-uridine 2-thiolation (cytoplasmic)"
APLA006699-PA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
APLA006869-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA000220-PA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
APLA014717-PA	4	KEGG: 00510+2.4.1.258;Reactome: R-HSA-4720475;KEGG: 00513+2.4.1.258;Reactome: R-HSA-446193	"N-Glycan biosynthesis";"Defective ALG3 causes ALG3-CDG (CDG-1d)";"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
APLA001458-PA	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
APLA006656-PA	7	KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1	"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection"
APLA002125-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA012883-PA	9	Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-6807505;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-76042;Reactome: R-HSA-167172	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome"
APLA001157-PA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
APLA009771-PA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
APLA001749-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA014037-PA	52	Reactome: R-HSA-73780;Reactome: R-HSA-6782210;Reactome: R-HSA-72165;Reactome: R-HSA-6807505;Reactome: R-HSA-73772;Reactome: R-HSA-6796648;Reactome: R-HSA-5617472;Reactome: R-HSA-749476;Reactome: R-HSA-6781827;Reactome: R-HSA-76066;Reactome: R-HSA-167238;Reactome: R-HSA-9018519;Reactome: R-HSA-167242;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-73762;Reactome: R-HSA-76061;Reactome: R-HSA-75955;Reactome: R-HSA-5601884;Reactome: R-HSA-77075;Reactome: R-HSA-73980;Reactome: R-HSA-6782135;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167160;Reactome: R-HSA-203927;Reactome: R-HSA-8851708;Reactome: R-HSA-72163;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-5578749;Reactome: R-HSA-75953;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-73863;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-5250924	"RNA Polymerase III Chain Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Minor Pathway";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase I Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase III Abortive And Retractive Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Pausing and recovery of Tat-mediated HIV elongation";"Estrogen-dependent gene expression";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase I Transcription Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase II Transcription Elongation";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase III Transcription Termination";"Dual incision in TC-NER";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"MicroRNA (miRNA) biogenesis";"Signaling by FGFR2 IIIa TM";"mRNA Splicing - Major Pathway";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Transcriptional regulation by small RNAs";"RNA Polymerase II Transcription Initiation";"mRNA Capping";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Termination";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"Transcription of the HIV genome";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"B-WICH complex positively regulates rRNA expression"
APLA010074-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA003272-PA	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
APLA006902-PA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
APLA000371-PA	2	Reactome: R-HSA-4755609;Reactome: R-HSA-446199	"Defective DHDDS causes retinitis pigmentosa 59";"Synthesis of Dolichyl-phosphate"
APLA006785-PA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
APLA004331-PA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
APLA001142-PA	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
APLA005427-PA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
APLA008294-PA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
APLA006919-PA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
APLA014515-PA	2	Reactome: R-HSA-3214815;Reactome: R-HSA-427413	"HDACs deacetylate histones";"NoRC negatively regulates rRNA expression"
APLA012878-PA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
APLA009161-PA	8	MetaCyc: PWY-5739;MetaCyc: PWY-7573;KEGG: 00051+4.2.1.47;MetaCyc: PWY-66;MetaCyc: PWY-5740;MetaCyc: PWY-5738;KEGG: 00520+4.2.1.47;Reactome: R-HSA-6787639	"GDP-D-perosamine biosynthesis";"GDP-mycosamine biosynthesis";"Fructose and mannose metabolism";"GDP-L-fucose biosynthesis I (from GDP-D-mannose)";"GDP-L-colitose biosynthesis";"GDP-6-deoxy-D-talose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"GDP-fucose biosynthesis"
APLA011609-PA	3	Reactome: R-HSA-1650814;MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2	"Collagen biosynthesis and modifying enzymes";"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism"
APLA000633-PA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
APLA013278-PA	2	Reactome: R-HSA-1799339;Reactome: R-HSA-381038	"SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes"
APLA010443-PA	2	Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
APLA008885-PA	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
APLA004085-PA	4	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Laminin interactions"
APLA001864-PA	6	MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;Reactome: R-HSA-9640463	"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis"
APLA005733-PA	7	Reactome: R-HSA-71064;KEGG: 00310+2.3.1.61;Reactome: R-HSA-71403;KEGG: 00380+2.3.1.61;KEGG: 00020+2.3.1.61;Reactome: R-HSA-389661;MetaCyc: PWY-5084	"Lysine catabolism";"Lysine degradation";"Citric acid cycle (TCA cycle)";"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA"
APLA010991-PA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
APLA005848-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA010315-PA	3	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
APLA002501-PA	2	Reactome: R-HSA-446205;KEGG: 00500+2.4.1.15	"Synthesis of GDP-mannose";"Starch and sucrose metabolism"
APLA003010-PA	13	MetaCyc: PWY-7883;KEGG: 00531+3.2.1.52;KEGG: 00603+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00520+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-1660662;Reactome: R-HSA-2022857	"Anhydromuropeptides recycling II";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Hyaluronan uptake and degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"CS/DS degradation";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Glycosphingolipid metabolism";"Keratan sulfate degradation"
APLA007494-PA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
APLA012591-PA	3	KEGG: 00970+6.1.1.19;Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
APLA014442-PA	13	Reactome: R-HSA-2871809;KEGG: 04070+3.1.4.11;Reactome: R-HSA-202433;Reactome: R-HSA-2424491;KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204;MetaCyc: PWY-6367;Reactome: R-HSA-2029485;MetaCyc: PWY-6351;MetaCyc: PWY-7039;Reactome: R-HSA-2871796;MetaCyc: PWY-8052;Reactome: R-HSA-9027277	"FCERI mediated Ca+2 mobilization";"Phosphatidylinositol signaling system";"Generation of second messenger molecules";"DAP12 signaling";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol-5-phosphate metabolism";"Role of phospholipids in phagocytosis";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"FCERI mediated MAPK activation";"2-arachidonoylglycerol biosynthesis";"Erythropoietin activates Phospholipase C gamma (PLCG)"
APLA004371-PA	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
APLA004087-PA	4	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000178	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"ECM proteoglycans"
APLA001557-PA	2	KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7	"Aminobenzoate degradation";"Pyruvate metabolism"
APLA004820-PA	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
APLA000767-PA	3	Reactome: R-HSA-3928662;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
APLA005995-PA	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
APLA000227-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA012855-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
APLA001622-PA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-9633012	"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
APLA008175-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA013146-PA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
APLA009726-PA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
APLA011311-PA	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
APLA002471-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA007623-PA	2	Reactome: R-HSA-1483148;Reactome: R-HSA-1483166	"Synthesis of PG";"Synthesis of PA"
APLA009185-PA	14	Reactome: R-HSA-167290;Reactome: R-HSA-167242;Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-167158	"Pausing and recovery of HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex"
APLA012128-PA	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
APLA008115-PA	13	Reactome: R-HSA-8964038;Reactome: R-HSA-8856828;Reactome: R-HSA-2132295;Reactome: R-HSA-177504;Reactome: R-HSA-5099900;Reactome: R-HSA-167590;Reactome: R-HSA-8856825;Reactome: R-HSA-8866427;Reactome: R-HSA-182218;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-437239;Reactome: R-HSA-5140745	"LDL clearance";"Clathrin-mediated endocytosis";"MHC class II antigen presentation";"Retrograde neurotrophin signalling";"WNT5A-dependent internalization of FZD4";"Nef Mediated CD4 Down-regulation";"Cargo recognition for clathrin-mediated endocytosis";"VLDLR internalisation and degradation";"Nef Mediated CD8 Down-regulation";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"Recycling pathway of L1";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2"
APLA014750-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA002169-PA	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
APLA005798-PA	2	Reactome: R-HSA-5619061;Reactome: R-HSA-425397	"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)";"Transport of vitamins, nucleosides, and related molecules"
APLA000113-PA	7	Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-1834949;Reactome: R-HSA-76071	"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter"
APLA009359-PA	1	Reactome: R-HSA-8876725	"Protein methylation"
APLA001425-PA	5	MetaCyc: PWY-7822;Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14	"Chitin degradation III (Serratia)";"Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism"
APLA001062-PA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
APLA004459-PA	11	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-383280;Reactome: R-HSA-400206;Reactome: R-HSA-1368082;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-1368108;Reactome: R-HSA-9018519;Reactome: R-HSA-212436	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"Nuclear Receptor transcription pathway";"Regulation of lipid metabolism by PPARalpha";"RORA activates gene expression";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Estrogen-dependent gene expression";"Generic Transcription Pathway"
APLA003694-PA	3	Reactome: R-HSA-8875656;Reactome: R-HSA-8856828;Reactome: R-HSA-8854214	"MET receptor recycling";"Clathrin-mediated endocytosis";"TBC/RABGAPs"
APLA010330-PA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
APLA005697-PA	16	Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane"
APLA005382-PA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
APLA014671-PA	3	Reactome: R-HSA-977347;KEGG: 00260+3.1.3.3;KEGG: 00680+3.1.3.3	"Serine biosynthesis";"Glycine, serine and threonine metabolism";"Methane metabolism"
APLA004213-PA	1	KEGG: 00970+6.1.1.22	"Aminoacyl-tRNA biosynthesis"
APLA001199-PA	3	Reactome: R-HSA-6785470;Reactome: R-HSA-8868766;Reactome: R-HSA-6784531	"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA processing in the nucleus"
APLA013252-PA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
APLA006053-PA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
APLA004586-PA	2	Reactome: R-HSA-168138;Reactome: R-HSA-983231	"Toll Like Receptor 9 (TLR9) Cascade";"Factors involved in megakaryocyte development and platelet production"
APLA002072-PA	31	MetaCyc: PWY-6113;MetaCyc: PWY-8049;MetaCyc: PWY-7663;MetaCyc: PWY-5966-1;Reactome: R-HSA-163765;MetaCyc: PWY-5971;MetaCyc: PWY-7388;MetaCyc: PWY-5994;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-6519;MetaCyc: PWY-8047;MetaCyc: PWY-8012;MetaCyc: PWY-7723;MetaCyc: PWY-4381;Reactome: R-HSA-2426168;MetaCyc: PWY-5973;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-5142;MetaCyc: PWY-6799;MetaCyc: PWY-7664;MetaCyc: PWY-5989;Reactome: R-HSA-199220;MetaCyc: PWYG-321;MetaCyc: PWY-5367;MetaCyc: PWY-5147;MetaCyc: PWY-5366;Reactome: R-HSA-75105;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-7746;MetaCyc: PWY-6282	"Superpathway of mycolate biosynthesis";"Pederin biosynthesis";"Gondoate biosynthesis (anaerobic)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"ChREBP activates metabolic gene expression";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Biotin metabolism";"8-amino-7-oxononanoate biosynthesis I";"Bryostatin biosynthesis";"Mupirocin biosynthesis";"Bacterial bioluminescence";"Fatty acid biosynthesis initiation (bacteria and plants)";"Activation of gene expression by SREBF (SREBP)";"Cis-vaccenate biosynthesis";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"Fatty acid biosynthesis initiation (plant mitochondria)";"Oleate biosynthesis IV (anaerobic)";"Stearate biosynthesis II (bacteria and plants)";"Vitamin B5 (pantothenate) metabolism";"";"Petroselinate biosynthesis";"Oleate biosynthesis I (plants)";"Palmitoleate biosynthesis II (plants and bacteria)";"Fatty acyl-CoA biosynthesis";"Fatty acid biosynthesis";"Mycobacterial sulfolipid biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"
APLA001255-PA	3	KEGG: 00790+2.8.1.9;Reactome: R-HSA-947581;MetaCyc: PWY-5963	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Thio-molybdenum cofactor biosynthesis"
APLA007620-PA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
APLA003799-PA	3	Reactome: R-HSA-6804760;Reactome: R-HSA-3214858;Reactome: R-HSA-191859	"Regulation of TP53 Activity through Methylation";"RMTs methylate histone arginines";"snRNP Assembly"
APLA005723-PA	2	Reactome: R-HSA-5687128;KEGG: 04150+2.7.11.24	"MAPK6/MAPK4 signaling";"mTOR signaling pathway"
APLA006355-PA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
APLA006728-PA	7	MetaCyc: PWY-6611;Reactome: R-HSA-5683826;MetaCyc: PWY-7179-1;MetaCyc: PWY-6609;MetaCyc: PWY-7179;Reactome: R-HSA-6798695;KEGG: 00230+3.5.4.4	"Adenine and adenosine salvage V";"Surfactant metabolism";"Purine deoxyribonucleosides degradation II";"Adenine and adenosine salvage III";"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Purine metabolism"
APLA012318-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA002642-PA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
APLA007157-PA	7	Reactome: R-HSA-5083633;Reactome: R-HSA-5083629;Reactome: R-HSA-5083628;Reactome: R-HSA-9010553;Reactome: R-HSA-3000178;Reactome: R-HSA-3000171;Reactome: R-HSA-5173105	"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Regulation of expression of SLITs and ROBOs";"ECM proteoglycans";"Non-integrin membrane-ECM interactions";"O-linked glycosylation"
APLA013640-PA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
APLA014378-PA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
APLA007034-PA	1	Reactome: R-HSA-6798163	"Choline catabolism"
APLA008779-PA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8949613	"Mitochondrial protein import";"Cristae formation"
APLA004325-PA	11	MetaCyc: PWY-5659;KEGG: 00520+5.3.1.8;MetaCyc: PWY-3881;MetaCyc: PWY-7586;MetaCyc: PWY-882;Reactome: R-HSA-4043916;MetaCyc: PWY-7456;MetaCyc: PWY-6992;Reactome: R-HSA-446205;MetaCyc: PWY-3861;KEGG: 00051+5.3.1.8	"GDP-mannose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Mannitol biosynthesis";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"L-ascorbate biosynthesis I (L-galactose pathway)";"Defective MPI causes MPI-CDG (CDG-1b)";"Beta-(1,4)-mannan degradation";"1,5-anhydrofructose degradation";"Synthesis of GDP-mannose";"Mannitol degradation II";"Fructose and mannose metabolism"
APLA006943-PA	56	Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-174154;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5678895;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-5358346;Reactome: R-HSA-349425;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-5362768;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-195253;Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-8939236;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-4641257;Reactome: R-HSA-187577;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-69601;Reactome: R-HSA-68827	"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdc20 mediated degradation of Securin";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"Separation of Sister Chromatids";"Neddylation";"Defective CFTR causes cystic fibrosis";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Hedgehog ligand biogenesis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of beta-catenin by the destruction complex";"Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Degradation of AXIN";"SCF(Skp2)-mediated degradation of p27/p21";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex"
APLA005020-PA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
APLA012188-PA	3	Reactome: R-HSA-1268020;Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Mitochondrial protein import";"Respiratory electron transport";"Complex I biogenesis"
APLA007133-PA	3	Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-191859	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"snRNP Assembly"
APLA006016-PA	11	Reactome: R-HSA-68962;Reactome: R-HSA-68952;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-5696400;Reactome: R-HSA-5651801;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-174430	"Activation of the pre-replicative complex";"DNA replication initiation";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"Dual Incision in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"Telomere C-strand synthesis initiation"
APLA002510-PA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
APLA002707-PA	2	Reactome: R-HSA-162588;Reactome: R-HSA-917729	"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)"
APLA008707-PA	1	Reactome: R-HSA-8951664	"Neddylation"
APLA010075-PA	4	KEGG: 00970+6.1.1.11;MetaCyc: PWY-6281;Reactome: R-HSA-379716;Reactome: R-HSA-2408557	"Aminoacyl-tRNA biosynthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Cytosolic tRNA aminoacylation";"Selenocysteine synthesis"
APLA005762-PA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
APLA001825-PA	1	Reactome: R-HSA-427413	"NoRC negatively regulates rRNA expression"
APLA001231-PA	1	KEGG: 00270+2.1.1.37	"Cysteine and methionine metabolism"
APLA003532-PA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
APLA015199-PA	3	KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3;MetaCyc: PWY-6317	"Galactose metabolism";"Glycolysis / Gluconeogenesis";"D-galactose degradation I (Leloir pathway)"
APLA001673-PA	9	KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-8853383;KEGG: 00600+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.25	"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Glycosaminoglycan degradation";"Other glycan degradation";"Lysosomal oligosaccharide catabolism";"Sphingolipid metabolism";"Neutrophil degranulation";"Other glycan degradation"
APLA000202-PA	8	KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1	"mTOR signaling pathway";"Thermogenesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway"
APLA013588-PA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
APLA011286-PA	5	Reactome: R-HSA-8964539;MetaCyc: PWY-4981;MetaCyc: PWY-3341;KEGG: 00330+1.5.1.2;MetaCyc: PWY-6344	"Glutamate and glutamine metabolism";"L-proline biosynthesis II (from arginine)";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism";"L-ornithine degradation II (Stickland reaction)"
APLA009481-PA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
APLA008016-PA	4	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling"
APLA000768-PA	12	MetaCyc: PWY-6932;Reactome: R-HSA-2408550;Reactome: R-HSA-174362;MetaCyc: PWY-5340;KEGG: 00920+2.7.7.4;KEGG: 00230+2.7.7.4;MetaCyc: PWY-5278;MetaCyc: PWY-6683;KEGG: 00450+2.7.7.4;KEGG: 00261+2.7.7.4;KEGG: 00920+2.7.1.25;KEGG: 00230+2.7.1.25	"Selenate reduction";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Transport and synthesis of PAPS";"Sulfate activation for sulfonation";"Sulfur metabolism";"Purine metabolism";"Sulfite oxidation III";"Assimilatory sulfate reduction III";"Selenocompound metabolism";"Monobactam biosynthesis";"Sulfur metabolism";"Purine metabolism"
APLA005472-PA	3	MetaCyc: PWY-7831;Reactome: R-HSA-9033807;MetaCyc: PWY-7833	"ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide";"ABO blood group biosynthesis";"Biosynthesis of Lewis epitopes (H. pylori)"
APLA002304-PA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
APLA014015-PA	22	Reactome: R-HSA-5628897;MetaCyc: PWY-7347;MetaCyc: PWY-5054;KEGG: 00500+5.3.1.9;MetaCyc: PWY-3801;MetaCyc: PWY-6981;MetaCyc: PWY-621;Reactome: R-HSA-6798695;MetaCyc: PWY-6142;MetaCyc: PWY-7238;MetaCyc: PWY-5514;MetaCyc: PWY-7385;Reactome: R-HSA-70171;MetaCyc: PWY-5384;MetaCyc: PWY-622;KEGG: 00030+5.3.1.9;KEGG: 00010+5.3.1.9;Reactome: R-HSA-70263;MetaCyc: PWY-5659;KEGG: 00520+5.3.1.9;MetaCyc: PWY-6992;MetaCyc: PWY-8013	"TP53 Regulates Metabolic Genes";"Sucrose biosynthesis III";"D-sorbitol biosynthesis I";"Starch and sucrose metabolism";"Sucrose degradation II (sucrose synthase)";"Chitin biosynthesis";"Sucrose degradation III (sucrose invertase)";"Neutrophil degranulation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Sucrose biosynthesis II";"UDP-N-acetyl-D-galactosamine biosynthesis II";"1,3-propanediol biosynthesis (engineered)";"Glycolysis";"Sucrose degradation IV (sucrose phosphorylase)";"Starch biosynthesis";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"GDP-mannose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"1,5-anhydrofructose degradation";"UDP-N-acetyl-D-galactosamine biosynthesis III"
APLA001232-PA	1	Reactome: R-HSA-480985	"Synthesis of dolichyl-phosphate-glucose"
APLA000427-PA	33	Reactome: R-HSA-3232142;Reactome: R-HSA-4615885;Reactome: R-HSA-2500257;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-68877;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-3301854;Reactome: R-HSA-9648025;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-5619107;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-6784531;Reactome: R-HSA-9610379;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-159227;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-168271;Reactome: R-HSA-141444;Reactome: R-HSA-165054	"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA replication proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"Mitotic Prometaphase";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Nuclear Pore Complex (NPC) Disassembly";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"tRNA processing in the nucleus";"HCMV Late Events";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP independent Mature mRNA";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Rev-mediated nuclear export of HIV RNA"
APLA003250-PA	20	Reactome: R-HSA-9033241;MetaCyc: PWY-7338;MetaCyc: PWY-7337;MetaCyc: PWY-7726;MetaCyc: PWY-5136;MetaCyc: PWY-7288;MetaCyc: PWY-735;MetaCyc: PWY-7340;KEGG: 00640+1.3.3.6;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6837;MetaCyc: PWY-7854;MetaCyc: PWY-7291;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7574;MetaCyc: PWY-7858;MetaCyc: PWY-6920;MetaCyc: PWY-7606;MetaCyc: PWY-7007;KEGG: 00592+1.3.3.6	"Peroxisomal protein import";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Jasmonic acid biosynthesis";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Propanoate metabolism";"Fatty acid degradation";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"beta-Alanine metabolism";"Propanoyl-coa degradation II";"(5Z)-dodecenoate biosynthesis II";"6-gingerol analog biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Methyl ketone biosynthesis (engineered)";"alpha-Linolenic acid metabolism"
APLA012098-PA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
APLA007352-PA	1	Reactome: R-HSA-977347	"Serine biosynthesis"
APLA014252-PA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
APLA012418-PA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-197264;KEGG: 00760+6.3.4.21;MetaCyc: PWY-5381;Reactome: R-HSA-1368108	"Neutrophil degranulation";"Nicotinamide salvaging";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression"
APLA004137-PA	27	Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-5619107;Reactome: R-HSA-170822;Reactome: R-HSA-159227;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-180746;Reactome: R-HSA-4570464;Reactome: R-HSA-3301854;Reactome: R-HSA-159230	"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP independent Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"Nuclear import of Rev protein";"SUMOylation of RNA binding proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA"
APLA005084-PA	2	KEGG: 00030+2.7.1.15;Reactome: R-HSA-71336	"Pentose phosphate pathway";"Pentose phosphate pathway"
APLA000891-PA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
APLA008313-PA	3	Reactome: R-HSA-375276;Reactome: R-HSA-418594;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (i) signalling events";"G alpha (q) signalling events"
APLA001948-PA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-6796648	"Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes"
APLA011663-PA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
APLA014003-PA	17	Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-141430;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-174184;Reactome: R-HSA-176412;Reactome: R-HSA-2559582;Reactome: R-HSA-174048;Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-176407;Reactome: R-HSA-69017;Reactome: R-HSA-176408	"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Phosphorylation of the APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Cyclin B";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"Neddylation";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of APC/C activators between G1/S and early anaphase"
APLA012424-PA	4	Reactome: R-HSA-6781823;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395	"Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER"
APLA008489-PA	25	Reactome: R-HSA-8936459;Reactome: R-HSA-8939247;Reactome: R-HSA-9018519;Reactome: R-HSA-8951936;Reactome: R-HSA-8939243;Reactome: R-HSA-8941284;Reactome: R-HSA-8951911;Reactome: R-HSA-8939902;Reactome: R-HSA-8941326;Reactome: R-HSA-8941333;Reactome: R-HSA-8931987;Reactome: R-HSA-8878166;Reactome: R-HSA-8877330;Reactome: R-HSA-8939256;Reactome: R-HSA-8949275;Reactome: R-HSA-8939245;Reactome: R-HSA-8939236;Reactome: R-HSA-8939242;Reactome: R-HSA-8939246;Reactome: R-HSA-9616222;Reactome: R-HSA-8940973;Reactome: R-HSA-8935964;Reactome: R-HSA-8934593;Reactome: R-HSA-8941332;Reactome: R-HSA-8941858	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX1 regulates transcription of genes involved in interleukin signaling";"Estrogen-dependent gene expression";"RUNX3 regulates p14-ARF";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RUNX2 regulates chondrocyte maturation";"RUNX3 regulates RUNX1-mediated transcription";"Regulation of RUNX2 expression and activity";"RUNX2 regulates bone development";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates estrogen receptor mediated transcription";"Transcriptional regulation by RUNX2";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX1 regulates transcription of genes involved in WNT signaling";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"Transcriptional regulation of granulopoiesis";"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates expression of components of tight junctions";"Regulation of RUNX1 Expression and Activity";"RUNX2 regulates genes involved in cell migration";"Regulation of RUNX3 expression and activity"
APLA009703-PA	30	Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-6782135;Reactome: R-HSA-167246;Reactome: R-HSA-6782210;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-5696395;Reactome: R-HSA-2564830;Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-167160;Reactome: R-HSA-112382;Reactome: R-HSA-73772;Reactome: R-HSA-6796648	"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"Formation of the Early Elongation Complex";"mRNA Capping";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"Dual incision in TC-NER";"Tat-mediated elongation of the HIV-1 transcript";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of Incision Complex in GG-NER";"Cytosolic iron-sulfur cluster assembly";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes"
APLA001189-PA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
APLA010497-PA	14	MetaCyc: PWY-7218;MetaCyc: PWY-1042;MetaCyc: PWY-6142;MetaCyc: PWY-7124;MetaCyc: PWY-6901;MetaCyc: PWY-5484;MetaCyc: PWY-6886;MetaCyc: PWY-2221;MetaCyc: PWY-1622;KEGG: 00010+4.2.1.11;MetaCyc: PWY-5723;MetaCyc: PWY-7003;MetaCyc: PWY-8004;KEGG: 00680+4.2.1.11	"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Ethylene biosynthesis V (engineered)";"Superpathway of glucose and xylose degradation";"Glycolysis II (from fructose 6-phosphate)";"1-butanol autotrophic biosynthesis (engineered)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Formaldehyde assimilation I (serine pathway)";"Glycolysis / Gluconeogenesis";"Rubisco shunt";"Glycerol degradation to butanol";"Entner-Doudoroff pathway I";"Methane metabolism"
APLA014439-PA	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
APLA000822-PA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
APLA000563-PA	1	Reactome: R-HSA-110357	"Displacement of DNA glycosylase by APEX1"
APLA001185-PA	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
APLA002857-PA	4	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-6807505;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"RNA polymerase II transcribes snRNA genes";"Th1 and Th2 cell differentiation"
APLA006986-PA	1	Reactome: R-HSA-156588	"Glucuronidation"
APLA000204-PA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
APLA001417-PA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"