Pathway_ID Pathway_Name Accession_Count Accessions Reactome: R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway 3 APLA014272-PA;APLA002288-PA;APLA006858-PA MetaCyc: PWY-7224 Purine deoxyribonucleosides salvage 3 APLA009372-PA;APLA000359-PA;APLA002995-PA KEGG: 00900+3.4.24.84 Terpenoid backbone biosynthesis 3 APLA008403-PA;APLA003784-PA;APLA007929-PA Reactome: R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 5 APLA014513-PA;APLA008659-PA;APLA008612-PA;APLA006690-PA;APLA007371-PA Reactome: R-HSA-8851708 Signaling by FGFR2 IIIa TM 14 APLA008112-PA;APLA002938-PA;APLA003046-PA;APLA006899-PA;APLA002937-PA;APLA000743-PA;APLA003842-PA;APLA015000-PA;APLA014037-PA;APLA013703-PA;APLA008108-PA;APLA001551-PA;APLA014520-PA;APLA014999-PA Reactome: R-HSA-164378 PKA activation in glucagon signalling 10 APLA014278-PA;APLA005245-PA;APLA013400-PA;APLA010182-PA;APLA003348-PA;APLA009113-PA;APLA003037-PA;APLA007417-PA;APLA007416-PA;APLA003039-PA KEGG: 00020+1.1.1.42 Citrate cycle (TCA cycle) 1 APLA001137-PA KEGG: 00500+3.2.1.4 Starch and sucrose metabolism 5 APLA011824-PA;APLA007753-PA;APLA011825-PA;APLA007751-PA;APLA005900-PA Reactome: R-HSA-2500257 Resolution of Sister Chromatid Cohesion 42 APLA014307-PA;APLA015031-PA;APLA002135-PA;APLA001833-PA;APLA009660-PA;APLA010198-PA;APLA010197-PA;APLA015416-PA;APLA004383-PA;APLA001683-PA;APLA002909-PA;APLA014998-PA;APLA002859-PA;APLA000426-PA;APLA011986-PA;APLA014679-PA;APLA001633-PA;APLA013359-PA;APLA010596-PA;APLA002551-PA;APLA007552-PA;APLA001351-PA;APLA000427-PA;APLA002856-PA;APLA005242-PA;APLA002883-PA;APLA004639-PA;APLA010643-PA;APLA001953-PA;APLA009417-PA;APLA015058-PA;APLA010196-PA;APLA014048-PA;APLA008446-PA;APLA007858-PA;APLA012338-PA;APLA014772-PA;APLA003480-PA;APLA014850-PA;APLA013547-PA;APLA008230-PA;APLA013357-PA KEGG: 00620+6.4.1.1 Pyruvate metabolism 1 APLA013385-PA Reactome: R-HSA-114604 GPVI-mediated activation cascade 4 APLA013745-PA;APLA012421-PA;APLA005249-PA;APLA004850-PA MetaCyc: PWY-241 C4 photosynthetic carbon assimilation cycle, NADP-ME type 3 APLA014966-PA;APLA002692-PA;APLA008850-PA MetaCyc: PWY-7511 Protein ubiquitination 87 APLA009182-PA;APLA014538-PA;APLA009808-PA;APLA004891-PA;APLA014540-PA;APLA015248-PA;APLA007022-PA;APLA010503-PA;APLA009810-PA;APLA013711-PA;APLA000184-PA;APLA011528-PA;APLA005848-PA;APLA013154-PA;APLA007291-PA;APLA008125-PA;APLA007673-PA;APLA008811-PA;APLA011266-PA;APLA004126-PA;APLA008509-PA;APLA007396-PA;APLA001189-PA;APLA010419-PA;APLA004277-PA;APLA000784-PA;APLA015239-PA;APLA009827-PA;APLA009527-PA;APLA004094-PA;APLA003001-PA;APLA009944-PA;APLA010644-PA;APLA015063-PA;APLA015291-PA;APLA013070-PA;APLA003226-PA;APLA004089-PA;APLA009042-PA;APLA002453-PA;APLA008029-PA;APLA002507-PA;APLA011273-PA;APLA014255-PA;APLA003196-PA;APLA001556-PA;APLA001699-PA;APLA011325-PA;APLA006562-PA;APLA010457-PA;APLA007705-PA;APLA007426-PA;APLA008915-PA;APLA000482-PA;APLA008362-PA;APLA000522-PA;APLA003179-PA;APLA006851-PA;APLA007667-PA;APLA012554-PA;APLA002640-PA;APLA013282-PA;APLA012713-PA;APLA008361-PA;APLA015391-PA;APLA011346-PA;APLA009207-PA;APLA011347-PA;APLA008497-PA;APLA005762-PA;APLA003532-PA;APLA013281-PA;APLA012477-PA;APLA012828-PA;APLA000681-PA;APLA005604-PA;APLA000668-PA;APLA001623-PA;APLA006185-PA;APLA000168-PA;APLA001749-PA;APLA009090-PA;APLA003615-PA;APLA009043-PA;APLA012176-PA;APLA011230-PA;APLA003531-PA MetaCyc: PWY-5740 GDP-L-colitose biosynthesis 2 APLA009143-PA;APLA009161-PA Reactome: R-HSA-983231 Factors involved in megakaryocyte development and platelet production 18 APLA008291-PA;APLA012878-PA;APLA014681-PA;APLA010182-PA;APLA002447-PA;APLA008294-PA;APLA001112-PA;APLA004850-PA;APLA012876-PA;APLA003348-PA;APLA009113-PA;APLA004453-PA;APLA011310-PA;APLA003843-PA;APLA002323-PA;APLA003180-PA;APLA009379-PA;APLA004586-PA Reactome: R-HSA-450341 Activation of the AP-1 family of transcription factors 2 APLA002140-PA;APLA004432-PA KEGG: 00310+1.14.11.8 Lysine degradation 1 APLA009139-PA KEGG: 00562+2.7.1.134+2.7.1.159 Inositol phosphate metabolism 1 APLA003180-PA KEGG: 00670+2.1.2.2 One carbon pool by folate 1 APLA005811-PA Reactome: R-HSA-73856 RNA Polymerase II Transcription Termination 28 APLA001717-PA;APLA002937-PA;APLA014338-PA;APLA000465-PA;APLA008641-PA;APLA010675-PA;APLA014042-PA;APLA002938-PA;APLA003898-PA;APLA010315-PA;APLA006970-PA;APLA003076-PA;APLA009518-PA;APLA015233-PA;APLA001716-PA;APLA014430-PA;APLA011282-PA;APLA012013-PA;APLA005894-PA;APLA012186-PA;APLA009489-PA;APLA009973-PA;APLA012011-PA;APLA004737-PA;APLA006974-PA;APLA005063-PA;APLA010637-PA;APLA015322-PA Reactome: R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 35 APLA000126-PA;APLA008836-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA008987-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA011713-PA;APLA008686-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA004504-PA;APLA010460-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA006943-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA005756-PA;APLA010347-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA011623-PA;APLA006607-PA;APLA002428-PA;APLA014272-PA;APLA002873-PA;APLA001313-PA;APLA014016-PA MetaCyc: PWY-7238 Sucrose biosynthesis II 6 APLA006828-PA;APLA014015-PA;APLA004011-PA;APLA003021-PA;APLA006822-PA;APLA004009-PA MetaCyc: PWY-7849 Urate conversion to allantoin III 1 APLA000730-PA Reactome: R-HSA-1369062 ABC transporters in lipid homeostasis 16 APLA000912-PA;APLA002526-PA;APLA008708-PA;APLA011023-PA;APLA005912-PA;APLA004193-PA;APLA003249-PA;APLA010993-PA;APLA008691-PA;APLA004196-PA;APLA001076-PA;APLA003267-PA;APLA002292-PA;APLA011000-PA;APLA002525-PA;APLA011024-PA Reactome: R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 10 APLA005953-PA;APLA002288-PA;APLA007136-PA;APLA006113-PA;APLA014272-PA;APLA014713-PA;APLA006117-PA;APLA008497-PA;APLA009966-PA;APLA008509-PA Reactome: R-HSA-451308 Activation of Ca-permeable Kainate Receptor 1 APLA002988-PA KEGG: 00500+2.7.7.9 Starch and sucrose metabolism 1 APLA003021-PA Reactome: R-HSA-68689 CDC6 association with the ORC:origin complex 8 APLA014433-PA;APLA013214-PA;APLA002390-PA;APLA008067-PA;APLA001663-PA;APLA010172-PA;APLA013902-PA;APLA007715-PA Reactome: R-HSA-77595 Processing of Intronless Pre-mRNAs 12 APLA002937-PA;APLA004737-PA;APLA006974-PA;APLA002938-PA;APLA006970-PA;APLA003076-PA;APLA015322-PA;APLA001716-PA;APLA011282-PA;APLA012013-PA;APLA001717-PA;APLA012011-PA Reactome: R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 11 APLA013309-PA;APLA009187-PA;APLA000209-PA;APLA011260-PA;APLA004532-PA;APLA009230-PA;APLA004611-PA;APLA012675-PA;APLA001105-PA;APLA001404-PA;APLA004868-PA MetaCyc: PWY-5480 Pyruvate fermentation to ethanol I 1 APLA001970-PA Reactome: R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 1 APLA000186-PA KEGG: 00020+1.2.4.1 Citrate cycle (TCA cycle) 2 APLA005998-PA;APLA001487-PA KEGG: 00640+1.3.3.6 Propanoate metabolism 2 APLA013190-PA;APLA003250-PA KEGG: 00450+1.8.1.9 Selenocompound metabolism 1 APLA011797-PA Reactome: R-HSA-75105 Fatty acyl-CoA biosynthesis 14 APLA002072-PA;APLA002545-PA;APLA001878-PA;APLA010586-PA;APLA002042-PA;APLA002547-PA;APLA010585-PA;APLA010583-PA;APLA010581-PA;APLA007857-PA;APLA010582-PA;APLA010588-PA;APLA010587-PA;APLA008923-PA Reactome: R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 3 APLA011103-PA;APLA002288-PA;APLA014272-PA Reactome: R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 3 APLA009113-PA;APLA003348-PA;APLA010182-PA Reactome: R-HSA-175474 Assembly Of The HIV Virion 2 APLA014272-PA;APLA002288-PA KEGG: 00260+4.2.1.22 Glycine, serine and threonine metabolism 1 APLA014127-PA Reactome: R-HSA-9613354 Lipophagy 1 APLA014601-PA Reactome: R-HSA-1855231 Synthesis of IPs in the ER lumen 1 APLA005745-PA Reactome: R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 2 APLA005338-PA;APLA000396-PA Reactome: R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 1 APLA002528-PA KEGG: 00970+6.1.1.17 Aminoacyl-tRNA biosynthesis 2 APLA011745-PA;APLA008833-PA MetaCyc: PWY-6644 Fluoroacetate and fluorothreonine biosynthesis 2 APLA013738-PA;APLA000262-PA MetaCyc: PWY-7437 Protein O-[N-acetyl]-glucosylation 2 APLA001077-PA;APLA009371-PA Reactome: R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 33 APLA011713-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA010460-PA;APLA004504-PA;APLA006975-PA;APLA011706-PA;APLA000810-PA;APLA000126-PA;APLA008836-PA;APLA008987-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA013223-PA;APLA015028-PA;APLA012977-PA;APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA014016-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA006943-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA005756-PA;APLA010347-PA Reactome: R-HSA-5676590 NIK-->noncanonical NF-kB signaling 36 APLA014016-PA;APLA006607-PA;APLA001313-PA;APLA014272-PA;APLA002428-PA;APLA002873-PA;APLA002934-PA;APLA012977-PA;APLA015028-PA;APLA013223-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA006943-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA004504-PA;APLA010460-PA;APLA008686-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA011713-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA011613-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA Reactome: R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 2 APLA006643-PA;APLA014443-PA KEGG: 00920+2.7.7.4 Sulfur metabolism 1 APLA000768-PA Reactome: R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1 APLA001517-PA Reactome: R-HSA-909733 Interferon alpha/beta signaling 1 APLA000109-PA Reactome: R-HSA-5610787 Hedgehog 'off' state 15 APLA006563-PA;APLA013400-PA;APLA010182-PA;APLA014278-PA;APLA005245-PA;APLA003348-PA;APLA009113-PA;APLA011623-PA;APLA004904-PA;APLA013455-PA;APLA007417-PA;APLA003039-PA;APLA007416-PA;APLA003037-PA;APLA010274-PA MetaCyc: PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 3 APLA002352-PA;APLA007954-PA;APLA013678-PA KEGG: 00720+6.4.1.3 Carbon fixation pathways in prokaryotes 1 APLA007201-PA KEGG: 00983+6.3.5.2 Drug metabolism - other enzymes 2 APLA005738-PA;APLA005740-PA Reactome: R-HSA-6809371 Formation of the cornified envelope 10 APLA003171-PA;APLA003163-PA;APLA004257-PA;APLA003169-PA;APLA003173-PA;APLA003183-PA;APLA010128-PA;APLA010127-PA;APLA014306-PA;APLA003172-PA KEGG: 00604+3.2.1.52 Glycosphingolipid biosynthesis - ganglio series 6 APLA003010-PA;APLA010555-PA;APLA001187-PA;APLA012599-PA;APLA006026-PA;APLA002044-PA MetaCyc: PWY-6545 Pyrimidine deoxyribonucleotides de novo biosynthesis III 9 APLA009372-PA;APLA002995-PA;APLA009005-PA;APLA009849-PA;APLA000359-PA;APLA012574-PA;APLA001202-PA;APLA001267-PA;APLA001305-PA Reactome: R-HSA-5250924 B-WICH complex positively regulates rRNA expression 14 APLA001551-PA;APLA005703-PA;APLA009344-PA;APLA013703-PA;APLA000669-PA;APLA014037-PA;APLA000743-PA;APLA002675-PA;APLA007670-PA;APLA014136-PA;APLA000630-PA;APLA003046-PA;APLA003311-PA;APLA011501-PA MetaCyc: PWY-6855 Chitin degradation I (archaea) 10 APLA000788-PA;APLA003813-PA;APLA003440-PA;APLA001426-PA;APLA007660-PA;APLA005525-PA;APLA010998-PA;APLA015396-PA;APLA001425-PA;APLA003546-PA KEGG: 00010+2.7.2.3 Glycolysis / Gluconeogenesis 2 APLA003817-PA;APLA003818-PA Reactome: R-HSA-9635465 Suppression of apoptosis 1 APLA002140-PA MetaCyc: PWY-5856 Ubiquinol-9 biosynthesis (prokaryotic) 1 APLA002418-PA Reactome: R-HSA-180910 Vpr-mediated nuclear import of PICs 16 APLA015058-PA;APLA006060-PA;APLA004137-PA;APLA001290-PA;APLA011447-PA;APLA002444-PA;APLA010643-PA;APLA003482-PA;APLA009708-PA;APLA000427-PA;APLA002878-PA;APLA005565-PA;APLA005336-PA;APLA005231-PA;APLA000426-PA;APLA011986-PA MetaCyc: PWY-6987 Lipoate biosynthesis and incorporation III (Bacillus) 5 APLA015266-PA;APLA003168-PA;APLA002544-PA;APLA009991-PA;APLA004383-PA MetaCyc: PWY-31 Canavanine degradation 1 APLA010889-PA MetaCyc: PWY-5067 Glycogen biosynthesis II (from UDP-D-Glucose) 5 APLA007993-PA;APLA001296-PA;APLA003655-PA;APLA001295-PA;APLA000677-PA Reactome: R-HSA-5657655 MGMT-mediated DNA damage reversal 1 APLA008491-PA Reactome: R-HSA-5687128 MAPK6/MAPK4 signaling 41 APLA005723-PA;APLA013702-PA;APLA014679-PA;APLA010460-PA;APLA004504-PA;APLA009856-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA011713-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA003047-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA000126-PA;APLA008836-PA;APLA014016-PA;APLA001313-PA;APLA014130-PA;APLA013701-PA;APLA002873-PA;APLA002428-PA;APLA014272-PA;APLA004850-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA006943-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA KEGG: 00010+5.3.1.1 Glycolysis / Gluconeogenesis 1 APLA006547-PA KEGG: 00592+1.1.1.1 alpha-Linolenic acid metabolism 1 APLA001970-PA MetaCyc: PWY-7586 Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation 2 APLA009743-PA;APLA004325-PA MetaCyc: PWY-6958 Icosapentaenoate biosynthesis I (lower eukaryotes) 2 APLA005258-PA;APLA008114-PA Reactome: R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 31 APLA003279-PA;APLA015000-PA;APLA001948-PA;APLA003842-PA;APLA014024-PA;APLA009185-PA;APLA000743-PA;APLA003046-PA;APLA001456-PA;APLA001541-PA;APLA005321-PA;APLA000879-PA;APLA001551-PA;APLA014037-PA;APLA010986-PA;APLA013703-PA;APLA005929-PA;APLA008920-PA;APLA000547-PA;APLA006924-PA;APLA008112-PA;APLA006899-PA;APLA001624-PA;APLA014999-PA;APLA009703-PA;APLA003187-PA;APLA014520-PA;APLA001596-PA;APLA011795-PA;APLA008108-PA;APLA003048-PA KEGG: 00401+2.6.1.1 Novobiocin biosynthesis 2 APLA012145-PA;APLA012983-PA KEGG: 00350+1.13.11.5 Tyrosine metabolism 1 APLA015390-PA MetaCyc: PWY-7049 Icosapentaenoate biosynthesis II (6-desaturase, mammals) 2 APLA005258-PA;APLA008114-PA KEGG: 00232+1.7.3.3 Caffeine metabolism 1 APLA010841-PA Reactome: R-HSA-176974 Unwinding of DNA 14 APLA007916-PA;APLA006933-PA;APLA010598-PA;APLA003313-PA;APLA014775-PA;APLA013769-PA;APLA008613-PA;APLA001682-PA;APLA011532-PA;APLA001307-PA;APLA014686-PA;APLA008611-PA;APLA009423-PA;APLA001388-PA Reactome: R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 42 APLA001601-PA;APLA008067-PA;APLA005704-PA;APLA013968-PA;APLA008836-PA;APLA000126-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA001663-PA;APLA008987-PA;APLA013902-PA;APLA004504-PA;APLA010460-PA;APLA013214-PA;APLA011713-PA;APLA008686-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA005756-PA;APLA010347-PA;APLA006695-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA006943-PA;APLA014433-PA;APLA002873-PA;APLA002428-PA;APLA002390-PA;APLA014272-PA;APLA001313-PA;APLA014016-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA010172-PA;APLA007715-PA Reactome: R-HSA-198693 AKT phosphorylates targets in the nucleus 1 APLA001921-PA Reactome: R-HSA-4655427 SUMOylation of DNA methylation proteins 2 APLA005906-PA;APLA004194-PA Reactome: R-HSA-2453864 Retinoid cycle disease events 1 APLA000730-PA Reactome: R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate 3 APLA012135-PA;APLA013280-PA;APLA007551-PA KEGG: 00350+1.1.1.1 Tyrosine metabolism 1 APLA001970-PA Reactome: R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 33 APLA006943-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA010347-PA;APLA005756-PA;APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA014016-PA;APLA014272-PA;APLA002873-PA;APLA002428-PA;APLA001313-PA;APLA008987-PA;APLA008836-PA;APLA000126-PA;APLA011706-PA;APLA006975-PA;APLA000810-PA;APLA013968-PA;APLA005704-PA;APLA001601-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA008686-PA;APLA011713-PA;APLA010460-PA;APLA004504-PA MetaCyc: PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II 3 APLA008936-PA;APLA012530-PA;APLA005811-PA KEGG: 00561+3.2.1.22 Glycerolipid metabolism 5 APLA007164-PA;APLA007466-PA;APLA007468-PA;APLA007467-PA;APLA007538-PA MetaCyc: PWY-4981 L-proline biosynthesis II (from arginine) 3 APLA011286-PA;APLA008941-PA;APLA001395-PA Reactome: R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 16 APLA009349-PA;APLA014716-PA;APLA010647-PA;APLA005863-PA;APLA012840-PA;APLA015208-PA;APLA009217-PA;APLA008961-PA;APLA003536-PA;APLA001432-PA;APLA013772-PA;APLA001768-PA;APLA000049-PA;APLA005862-PA;APLA014519-PA;APLA007959-PA Reactome: R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 5 APLA005011-PA;APLA006117-PA;APLA009966-PA;APLA006113-PA;APLA007945-PA KEGG: 00250+6.3.5.5 Alanine, aspartate and glutamate metabolism 1 APLA002345-PA Reactome: R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 4 APLA003300-PA;APLA009858-PA;APLA002140-PA;APLA007917-PA KEGG: 00052+3.2.1.26 Galactose metabolism 2 APLA000024-PA;APLA006128-PA Reactome: R-HSA-382556 ABC-family proteins mediated transport 42 APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA014016-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA006943-PA;APLA008790-PA;APLA010460-PA;APLA004504-PA;APLA011713-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA009873-PA;APLA008686-PA;APLA000968-PA;APLA001601-PA;APLA001762-PA;APLA013968-PA;APLA014029-PA;APLA005704-PA;APLA001687-PA;APLA001685-PA;APLA011706-PA;APLA006975-PA;APLA000810-PA;APLA012085-PA;APLA008836-PA;APLA000126-PA;APLA000970-PA;APLA008987-PA KEGG: 00330+4.1.1.50 Arginine and proline metabolism 1 APLA001210-PA MetaCyc: PWY-7382 Lipoate biosynthesis and incorporation IV (yeast) 5 APLA004383-PA;APLA003168-PA;APLA015266-PA;APLA002544-PA;APLA009991-PA Reactome: R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 41 APLA012977-PA;APLA005017-PA;APLA000940-PA;APLA005264-PA;APLA015028-PA;APLA013223-PA;APLA003055-PA;APLA014016-PA;APLA002428-PA;APLA014272-PA;APLA002873-PA;APLA001313-PA;APLA006943-PA;APLA014003-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA010347-PA;APLA007872-PA;APLA005756-PA;APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA008686-PA;APLA000806-PA;APLA011713-PA;APLA011005-PA;APLA004504-PA;APLA010460-PA;APLA008987-PA;APLA000126-PA;APLA008836-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA013968-PA;APLA005704-PA;APLA001601-PA KEGG: 00983+2.4.2.3 Drug metabolism - other enzymes 1 APLA001272-PA Reactome: R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 3 APLA014713-PA;APLA005953-PA;APLA007136-PA Reactome: R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 10 APLA005017-PA;APLA014003-PA;APLA002288-PA;APLA011005-PA;APLA000940-PA;APLA000806-PA;APLA005264-PA;APLA007872-PA;APLA003055-PA;APLA014272-PA KEGG: 00195+7.1.2.2 Photosynthesis 6 APLA006976-PA;APLA006973-PA;APLA010311-PA;APLA015230-PA;APLA009120-PA;APLA002666-PA MetaCyc: PWY-6609 Adenine and adenosine salvage III 5 APLA006726-PA;APLA000262-PA;APLA006728-PA;APLA013738-PA;APLA015153-PA Reactome: R-HSA-3928665 EPH-ephrin mediated repulsion of cells 10 APLA005626-PA;APLA009421-PA;APLA007136-PA;APLA005953-PA;APLA008767-PA;APLA008115-PA;APLA001668-PA;APLA010150-PA;APLA014713-PA;APLA001793-PA Reactome: R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1 APLA015273-PA Reactome: R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 1 APLA014442-PA MetaCyc: PWY-181 Photorespiration 1 APLA000499-PA MetaCyc: PWY-6886 1-butanol autotrophic biosynthesis (engineered) 7 APLA015268-PA;APLA010497-PA;APLA010500-PA;APLA007919-PA;APLA003818-PA;APLA003817-PA;APLA010499-PA MetaCyc: PWY-3341 L-proline biosynthesis III (from L-ornithine) 3 APLA011286-PA;APLA008941-PA;APLA001395-PA Reactome: R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS) 14 APLA011440-PA;APLA002840-PA;APLA001611-PA;APLA001547-PA;APLA005297-PA;APLA001819-PA;APLA001229-PA;APLA015383-PA;APLA004044-PA;APLA012691-PA;APLA015178-PA;APLA014312-PA;APLA001977-PA;APLA001617-PA Reactome: R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 36 APLA012079-PA;APLA014850-PA;APLA014048-PA;APLA008446-PA;APLA010196-PA;APLA007858-PA;APLA012338-PA;APLA013357-PA;APLA004923-PA;APLA014036-PA;APLA001953-PA;APLA003210-PA;APLA013644-PA;APLA014791-PA;APLA008326-PA;APLA002548-PA;APLA015228-PA;APLA009417-PA;APLA008398-PA;APLA015240-PA;APLA012969-PA;APLA014998-PA;APLA010596-PA;APLA002551-PA;APLA002301-PA;APLA013359-PA;APLA003620-PA;APLA015031-PA;APLA010197-PA;APLA014355-PA;APLA015416-PA;APLA008995-PA;APLA004383-PA;APLA010198-PA;APLA015241-PA;APLA004323-PA MetaCyc: PWY-7285 Methylwyosine biosynthesis 3 APLA007954-PA;APLA002352-PA;APLA013678-PA Reactome: R-HSA-5621575 CD209 (DC-SIGN) signaling 2 APLA001514-PA;APLA011837-PA KEGG: 00220+3.5.1.14 Arginine biosynthesis 1 APLA003981-PA KEGG: 00332+1.2.1.41 Carbapenem biosynthesis 1 APLA007436-PA MetaCyc: PWY-5022 4-aminobutanoate degradation V 1 APLA003896-PA Reactome: R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 1 APLA010601-PA Reactome: R-HSA-5218921 VEGFR2 mediated cell proliferation 3 APLA013745-PA;APLA015057-PA;APLA003653-PA Reactome: R-HSA-73772 RNA Polymerase I Promoter Escape 16 APLA009344-PA;APLA001596-PA;APLA009703-PA;APLA001624-PA;APLA003311-PA;APLA000630-PA;APLA014136-PA;APLA000879-PA;APLA001551-PA;APLA005703-PA;APLA013703-PA;APLA010986-PA;APLA014037-PA;APLA003279-PA;APLA000743-PA;APLA003046-PA Reactome: R-HSA-8866423 VLDL assembly 6 APLA003677-PA;APLA003678-PA;APLA002555-PA;APLA009851-PA;APLA003544-PA;APLA004787-PA KEGG: 00510+3.2.1.106 N-Glycan biosynthesis 1 APLA002968-PA Reactome: R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 13 APLA014958-PA;APLA014443-PA;APLA009424-PA;APLA013848-PA;APLA006644-PA;APLA009824-PA;APLA009662-PA;APLA008808-PA;APLA006643-PA;APLA003353-PA;APLA000365-PA;APLA009590-PA;APLA012406-PA MetaCyc: PWY-6938 NADH repair 2 APLA013034-PA;APLA011268-PA KEGG: 00230+2.7.4.3 Purine metabolism 6 APLA006751-PA;APLA015335-PA;APLA002792-PA;APLA014549-PA;APLA013251-PA;APLA008966-PA Reactome: R-HSA-69205 G1/S-Specific Transcription 14 APLA005348-PA;APLA008612-PA;APLA006695-PA;APLA014841-PA;APLA008494-PA;APLA012570-PA;APLA001691-PA;APLA011446-PA;APLA014513-PA;APLA013902-PA;APLA010172-PA;APLA001457-PA;APLA009142-PA;APLA009423-PA KEGG: 00380+1.2.4.2 Tryptophan metabolism 3 APLA003091-PA;APLA011349-PA;APLA007913-PA Reactome: R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1 APLA000270-PA MetaCyc: PWY-5751 Phenylethanol biosynthesis 1 APLA001970-PA MetaCyc: PWY-7118 Chitin degradation to ethanol 3 APLA008135-PA;APLA006387-PA;APLA001970-PA Reactome: R-HSA-8943723 Regulation of PTEN mRNA translation 5 APLA013702-PA;APLA013701-PA;APLA014130-PA;APLA009856-PA;APLA003047-PA KEGG: 04070+2.7.1.107 Phosphatidylinositol signaling system 5 APLA011921-PA;APLA011740-PA;APLA013224-PA;APLA006190-PA;APLA012308-PA Reactome: R-HSA-1614603 Cysteine formation from homocysteine 4 APLA012476-PA;APLA014103-PA;APLA011318-PA;APLA014127-PA MetaCyc: PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 2 APLA009161-PA;APLA009143-PA MetaCyc: PWY-7218 Photosynthetic 3-hydroxybutanoate biosynthesis (engineered) 5 APLA010499-PA;APLA010497-PA;APLA015268-PA;APLA010500-PA;APLA007919-PA MetaCyc: PWY-5691 Urate conversion to allantoin I 2 APLA000730-PA;APLA010841-PA KEGG: 00520+2.7.1.1 Amino sugar and nucleotide sugar metabolism 2 APLA001397-PA;APLA002389-PA Reactome: R-HSA-444257 RSK activation 2 APLA002140-PA;APLA013745-PA Reactome: R-HSA-5632968 Defective Mismatch Repair Associated With MSH6 1 APLA003508-PA Reactome: R-HSA-2468052 Establishment of Sister Chromatid Cohesion 3 APLA001842-PA;APLA001837-PA;APLA008230-PA Reactome: R-HSA-5675221 Negative regulation of MAPK pathway 7 APLA001038-PA;APLA002140-PA;APLA002288-PA;APLA009814-PA;APLA001633-PA;APLA014272-PA;APLA003480-PA Reactome: R-HSA-425381 Bicarbonate transporters 4 APLA009731-PA;APLA002083-PA;APLA015314-PA;APLA002082-PA MetaCyc: PWY-4061 Glutathione-mediated detoxification I 4 APLA004285-PA;APLA004293-PA;APLA014577-PA;APLA004294-PA Reactome: R-HSA-392517 Rap1 signalling 1 APLA004792-PA MetaCyc: PWY-5739 GDP-D-perosamine biosynthesis 2 APLA009143-PA;APLA009161-PA Reactome: R-HSA-933541 TRAF6 mediated IRF7 activation 3 APLA011837-PA;APLA011103-PA;APLA001514-PA Reactome: R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 6 APLA014679-PA;APLA001387-PA;APLA003682-PA;APLA012413-PA;APLA001596-PA;APLA005169-PA Reactome: R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 3 APLA001556-PA;APLA014272-PA;APLA002288-PA MetaCyc: PWY-4321 L-glutamate degradation IV 1 APLA003896-PA MetaCyc: PWY-6999 Theophylline degradation 1 APLA002333-PA KEGG: 00310+2.3.1.61 Lysine degradation 1 APLA005733-PA Reactome: R-HSA-70268 Pyruvate metabolism 7 APLA008758-PA;APLA003939-PA;APLA005998-PA;APLA000736-PA;APLA014770-PA;APLA001487-PA;APLA000737-PA Reactome: R-HSA-2173789 TGF-beta receptor signaling activates SMADs 1 APLA002559-PA KEGG: 00564+2.7.7.41 Glycerophospholipid metabolism 2 APLA002731-PA;APLA003095-PA Reactome: R-HSA-8878166 Transcriptional regulation by RUNX2 2 APLA008490-PA;APLA008489-PA KEGG: 00650+4.2.1.17+1.1.1.35 Butanoate metabolism 4 APLA000468-PA;APLA006174-PA;APLA014896-PA;APLA006178-PA MetaCyc: PWY-5101 L-isoleucine biosynthesis II 1 APLA006327-PA Reactome: R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 6 APLA010885-PA;APLA001000-PA;APLA007154-PA;APLA005305-PA;APLA005245-PA;APLA008660-PA Reactome: R-HSA-171007 p38MAPK events 2 APLA003690-PA;APLA005606-PA MetaCyc: PWY-4361 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I 6 APLA001298-PA;APLA013006-PA;APLA009072-PA;APLA004190-PA;APLA011701-PA;APLA001529-PA Reactome: R-HSA-5674499 Negative feedback regulation of MAPK pathway 1 APLA002140-PA Reactome: R-HSA-191273 Cholesterol biosynthesis 4 APLA012425-PA;APLA001403-PA;APLA005035-PA;APLA000828-PA Reactome: R-HSA-8939211 ESR-mediated signaling 2 APLA009814-PA;APLA002140-PA Reactome: R-HSA-9033807 ABO blood group biosynthesis 3 APLA002118-PA;APLA005473-PA;APLA005472-PA Reactome: R-HSA-3371571 HSF1-dependent transactivation 5 APLA014094-PA;APLA005545-PA;APLA007030-PA;APLA009758-PA;APLA004140-PA Reactome: R-HSA-500657 Presynaptic function of Kainate receptors 1 APLA006554-PA KEGG: 00240+1.17.4.1 Pyrimidine metabolism 2 APLA001267-PA;APLA012574-PA KEGG: 00910+4.2.1.1 Nitrogen metabolism 3 APLA014966-PA;APLA008850-PA;APLA002692-PA Reactome: R-HSA-5658442 Regulation of RAS by GAPs 35 APLA010460-PA;APLA004504-PA;APLA011713-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA008686-PA;APLA001601-PA;APLA013968-PA;APLA005704-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA000126-PA;APLA008836-PA;APLA008987-PA;APLA002001-PA;APLA001313-PA;APLA002428-PA;APLA002873-PA;APLA014272-PA;APLA014016-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA015057-PA;APLA006943-PA Reactome: R-HSA-2672351 Stimuli-sensing channels 27 APLA001314-PA;APLA013500-PA;APLA004181-PA;APLA010733-PA;APLA014272-PA;APLA013379-PA;APLA000738-PA;APLA004180-PA;APLA007863-PA;APLA000689-PA;APLA001876-PA;APLA007578-PA;APLA001217-PA;APLA000414-PA;APLA002019-PA;APLA002227-PA;APLA011224-PA;APLA005785-PA;APLA014059-PA;APLA002288-PA;APLA013499-PA;APLA001234-PA;APLA001018-PA;APLA000069-PA;APLA010870-PA;APLA001319-PA;APLA004889-PA Reactome: R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 86 APLA014272-PA;APLA014343-PA;APLA012986-PA;APLA003093-PA;APLA014985-PA;APLA010040-PA;APLA002294-PA;APLA012226-PA;APLA008225-PA;APLA007375-PA;APLA000130-PA;APLA000210-PA;APLA002625-PA;APLA005476-PA;APLA003509-PA;APLA005454-PA;APLA006586-PA;APLA011333-PA;APLA002288-PA;APLA014444-PA;APLA002114-PA;APLA010469-PA;APLA013308-PA;APLA014046-PA;APLA014384-PA;APLA005706-PA;APLA006618-PA;APLA004503-PA;APLA000605-PA;APLA014441-PA;APLA014029-PA;APLA001093-PA;APLA003014-PA;APLA005697-PA;APLA013210-PA;APLA012910-PA;APLA010605-PA;APLA000682-PA;APLA003770-PA;APLA006079-PA;APLA003102-PA;APLA000050-PA;APLA002086-PA;APLA005265-PA;APLA006555-PA;APLA010999-PA;APLA003269-PA;APLA009495-PA;APLA013231-PA;APLA008614-PA;APLA010839-PA;APLA013392-PA;APLA005404-PA;APLA009213-PA;APLA000488-PA;APLA004075-PA;APLA008588-PA;APLA010013-PA;APLA004544-PA;APLA012185-PA;APLA009753-PA;APLA005999-PA;APLA003286-PA;APLA007956-PA;APLA014107-PA;APLA001987-PA;APLA009234-PA;APLA005196-PA;APLA015197-PA;APLA001622-PA;APLA006227-PA;APLA012911-PA;APLA008766-PA;APLA006379-PA;APLA007492-PA;APLA009149-PA;APLA001686-PA;APLA015388-PA;APLA003217-PA;APLA011066-PA;APLA007319-PA;APLA012151-PA;APLA000956-PA;APLA005384-PA;APLA012609-PA;APLA003064-PA MetaCyc: PWY-7391 Isoprene biosynthesis II (engineered) 4 APLA012425-PA;APLA001403-PA;APLA000828-PA;APLA007166-PA MetaCyc: PWY-7836 Ganglio-series glycosphingolipids biosynthesis 1 APLA012402-PA MetaCyc: PWY-5384 Sucrose degradation IV (sucrose phosphorylase) 1 APLA014015-PA Reactome: R-HSA-209968 Thyroxine biosynthesis 2 APLA006050-PA;APLA008424-PA KEGG: 00564+3.1.1.7 Glycerophospholipid metabolism 1 APLA007870-PA MetaCyc: PWY-7210 Pyrimidine deoxyribonucleotides biosynthesis from CTP 11 APLA009142-PA;APLA014612-PA;APLA009372-PA;APLA002995-PA;APLA012076-PA;APLA000359-PA;APLA001267-PA;APLA012574-PA;APLA001202-PA;APLA008494-PA;APLA001305-PA Reactome: R-HSA-877312 Regulation of IFNG signaling 1 APLA009701-PA MetaCyc: PWY-5154 L-arginine biosynthesis III (via N-acetyl-L-citrulline) 1 APLA002345-PA Reactome: R-HSA-2206292 MPS VII - Sly syndrome 2 APLA001817-PA;APLA005795-PA Reactome: R-HSA-9010553 Regulation of expression of SLITs and ROBOs 111 APLA001601-PA;APLA001686-PA;APLA011066-PA;APLA015388-PA;APLA003217-PA;APLA012151-PA;APLA013968-PA;APLA000956-PA;APLA005384-PA;APLA006975-PA;APLA000810-PA;APLA000126-PA;APLA010675-PA;APLA003064-PA;APLA012609-PA;APLA014107-PA;APLA009234-PA;APLA004504-PA;APLA010460-PA;APLA007956-PA;APLA009489-PA;APLA006227-PA;APLA001622-PA;APLA012911-PA;APLA009149-PA;APLA015189-PA;APLA013844-PA;APLA006379-PA;APLA008766-PA;APLA007492-PA;APLA010839-PA;APLA013392-PA;APLA008614-PA;APLA005404-PA;APLA010347-PA;APLA009213-PA;APLA002937-PA;APLA008588-PA;APLA010995-PA;APLA010013-PA;APLA000488-PA;APLA004075-PA;APLA004544-PA;APLA009753-PA;APLA012185-PA;APLA003770-PA;APLA001313-PA;APLA010605-PA;APLA000682-PA;APLA005265-PA;APLA002086-PA;APLA006079-PA;APLA003102-PA;APLA010999-PA;APLA015028-PA;APLA013223-PA;APLA003269-PA;APLA009495-PA;APLA013231-PA;APLA006618-PA;APLA000605-PA;APLA014384-PA;APLA005706-PA;APLA005697-PA;APLA003014-PA;APLA005704-PA;APLA011706-PA;APLA008836-PA;APLA002938-PA;APLA012910-PA;APLA008987-PA;APLA013210-PA;APLA010469-PA;APLA014046-PA;APLA011713-PA;APLA013308-PA;APLA008686-PA;APLA004494-PA;APLA007157-PA;APLA002625-PA;APLA000210-PA;APLA000130-PA;APLA007463-PA;APLA007375-PA;APLA012593-PA;APLA005719-PA;APLA005756-PA;APLA005454-PA;APLA003509-PA;APLA010791-PA;APLA002288-PA;APLA011333-PA;APLA014042-PA;APLA008015-PA;APLA002114-PA;APLA006943-PA;APLA014444-PA;APLA012986-PA;APLA014343-PA;APLA012510-PA;APLA002004-PA;APLA002873-PA;APLA002428-PA;APLA014272-PA;APLA014985-PA;APLA014016-PA;APLA010040-PA;APLA002294-PA;APLA008225-PA;APLA012226-PA;APLA012977-PA KEGG: 00900+2.7.4.2 Terpenoid backbone biosynthesis 1 APLA001403-PA Reactome: R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 4 APLA003986-PA;APLA002074-PA;APLA000639-PA;APLA002200-PA Reactome: R-HSA-75893 TNF signaling 1 APLA007945-PA KEGG: 00240+2.7.4.9 Pyrimidine metabolism 1 APLA001202-PA Reactome: R-HSA-8953750 Transcriptional Regulation by E2F6 5 APLA000162-PA;APLA010316-PA;APLA009882-PA;APLA004907-PA;APLA008808-PA Reactome: R-HSA-5610780 Degradation of GLI1 by the proteasome 35 APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA006943-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA014016-PA;APLA006607-PA;APLA001313-PA;APLA002428-PA;APLA002873-PA;APLA014272-PA;APLA011623-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA004504-PA;APLA010460-PA;APLA008686-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA011713-PA MetaCyc: PWY-7619 Juniperonate biosynthesis 14 APLA010068-PA;APLA009871-PA;APLA000862-PA;APLA010065-PA;APLA015433-PA;APLA010066-PA;APLA002710-PA;APLA005258-PA;APLA010067-PA;APLA010063-PA;APLA008114-PA;APLA000863-PA;APLA010062-PA;APLA010064-PA KEGG: 00983+2.7.4.6 Drug metabolism - other enzymes 3 APLA002995-PA;APLA000359-PA;APLA009372-PA Reactome: R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 4 APLA014272-PA;APLA002288-PA;APLA006607-PA;APLA002934-PA KEGG: 00330+2.7.2.11+1.2.1.41 Arginine and proline metabolism 1 APLA007435-PA MetaCyc: PWY-7417 Phospholipid remodeling (phosphatidate, yeast) 12 APLA000543-PA;APLA009079-PA;APLA009078-PA;APLA004469-PA;APLA008027-PA;APLA012384-PA;APLA004147-PA;APLA014471-PA;APLA005749-PA;APLA005748-PA;APLA001975-PA;APLA012686-PA KEGG: 00900+2.2.1.7 Terpenoid backbone biosynthesis 1 APLA003487-PA KEGG: 05163+2.7.11.1 Human cytomegalovirus infection 35 APLA005614-PA;APLA005789-PA;APLA006656-PA;APLA000202-PA;APLA009255-PA;APLA002024-PA;APLA014432-PA;APLA004865-PA;APLA006809-PA;APLA005222-PA;APLA005545-PA;APLA001541-PA;APLA014655-PA;APLA010535-PA;APLA010570-PA;APLA006659-PA;APLA002693-PA;APLA009561-PA;APLA003559-PA;APLA014007-PA;APLA012309-PA;APLA014094-PA;APLA008151-PA;APLA011336-PA;APLA012070-PA;APLA013745-PA;APLA011405-PA;APLA011480-PA;APLA003517-PA;APLA005251-PA;APLA009103-PA;APLA015343-PA;APLA008080-PA;APLA001451-PA;APLA003690-PA KEGG: 00130+2.6.1.5 Ubiquinone and other terpenoid-quinone biosynthesis 1 APLA013125-PA MetaCyc: PWY-8043 Ophthalmate biosynthesis 6 APLA003096-PA;APLA013161-PA;APLA003098-PA;APLA009670-PA;APLA011246-PA;APLA011248-PA MetaCyc: PWY-6365 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 1 APLA003180-PA Reactome: R-HSA-197264 Nicotinamide salvaging 3 APLA012418-PA;APLA003120-PA;APLA007456-PA KEGG: 00620+6.4.1.2 Pyruvate metabolism 1 APLA013496-PA Reactome: R-HSA-8939902 Regulation of RUNX2 expression and activity 37 APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA000126-PA;APLA008836-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA004504-PA;APLA010460-PA;APLA008490-PA;APLA008686-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA011713-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA006943-PA;APLA008489-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA014016-PA;APLA006607-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA001313-PA;APLA012977-PA;APLA012828-PA;APLA013223-PA;APLA015028-PA Reactome: R-HSA-1660661 Sphingolipid de novo biosynthesis 6 APLA002479-PA;APLA006009-PA;APLA000592-PA;APLA008734-PA;APLA011772-PA;APLA001711-PA MetaCyc: PWY-7233 Ubiquinol-6 bypass biosynthesis (eukaryotic) 1 APLA002418-PA KEGG: 00010+4.2.1.11 Glycolysis / Gluconeogenesis 4 APLA010499-PA;APLA010497-PA;APLA010500-PA;APLA007919-PA Reactome: R-HSA-4549349 Defective ALG2 causes ALG2-CDG (CDG-1i) 2 APLA003772-PA;APLA006696-PA Reactome: R-HSA-3878781 Glycogen storage disease type IV (GBE1) 1 APLA003655-PA KEGG: 00970+6.1.1.10 Aminoacyl-tRNA biosynthesis 2 APLA001592-PA;APLA003938-PA Reactome: R-HSA-5205685 Pink/Parkin Mediated Mitophagy 9 APLA002288-PA;APLA012125-PA;APLA010491-PA;APLA000598-PA;APLA014272-PA;APLA005357-PA;APLA014264-PA;APLA013918-PA;APLA014681-PA Reactome: R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 130 APLA007956-PA;APLA011260-PA;APLA009234-PA;APLA014459-PA;APLA007492-PA;APLA006379-PA;APLA011531-PA;APLA009149-PA;APLA002426-PA;APLA006852-PA;APLA001622-PA;APLA003217-PA;APLA004341-PA;APLA012609-PA;APLA000956-PA;APLA004032-PA;APLA006079-PA;APLA002256-PA;APLA002086-PA;APLA008286-PA;APLA007878-PA;APLA000682-PA;APLA010091-PA;APLA009213-PA;APLA013392-PA;APLA001035-PA;APLA010839-PA;APLA001036-PA;APLA014332-PA;APLA010469-PA;APLA002533-PA;APLA012070-PA;APLA014046-PA;APLA014054-PA;APLA003014-PA;APLA001207-PA;APLA007891-PA;APLA014384-PA;APLA005706-PA;APLA000605-PA;APLA013210-PA;APLA004611-PA;APLA006509-PA;APLA006809-PA;APLA014343-PA;APLA008225-PA;APLA014137-PA;APLA003509-PA;APLA005454-PA;APLA007375-PA;APLA000209-PA;APLA000210-PA;APLA013884-PA;APLA011333-PA;APLA002288-PA;APLA004803-PA;APLA011026-PA;APLA002129-PA;APLA014107-PA;APLA001106-PA;APLA008766-PA;APLA008823-PA;APLA006227-PA;APLA001105-PA;APLA012911-PA;APLA014588-PA;APLA012151-PA;APLA012302-PA;APLA013309-PA;APLA001686-PA;APLA011066-PA;APLA015388-PA;APLA007137-PA;APLA001094-PA;APLA003064-PA;APLA011278-PA;APLA005384-PA;APLA003102-PA;APLA005265-PA;APLA010605-PA;APLA009362-PA;APLA006900-PA;APLA003770-PA;APLA009495-PA;APLA013231-PA;APLA006556-PA;APLA010999-PA;APLA003269-PA;APLA006854-PA;APLA005404-PA;APLA008614-PA;APLA013276-PA;APLA004544-PA;APLA012185-PA;APLA009753-PA;APLA000488-PA;APLA004075-PA;APLA010013-PA;APLA008588-PA;APLA011488-PA;APLA006697-PA;APLA000832-PA;APLA013308-PA;APLA005697-PA;APLA010330-PA;APLA006618-PA;APLA008275-PA;APLA012910-PA;APLA014787-PA;APLA006510-PA;APLA014985-PA;APLA014272-PA;APLA012986-PA;APLA004532-PA;APLA009465-PA;APLA012226-PA;APLA009479-PA;APLA001304-PA;APLA009230-PA;APLA010040-PA;APLA002294-PA;APLA000202-PA;APLA012675-PA;APLA009187-PA;APLA002625-PA;APLA000130-PA;APLA009184-PA;APLA014444-PA;APLA002114-PA;APLA011351-PA KEGG: 00680+2.7.1.11 Methane metabolism 2 APLA013705-PA;APLA013706-PA Reactome: R-HSA-3656532 TGFBR1 KD Mutants in Cancer 1 APLA002559-PA MetaCyc: PWY-7007 Methyl ketone biosynthesis (engineered) 6 APLA000468-PA;APLA013190-PA;APLA006174-PA;APLA003250-PA;APLA006178-PA;APLA014896-PA KEGG: 00760+2.7.7.18 Nicotinate and nicotinamide metabolism 1 APLA012508-PA Reactome: R-HSA-71240 Tryptophan catabolism 3 APLA001933-PA;APLA006567-PA;APLA008825-PA Reactome: R-HSA-8873719 RAB geranylgeranylation 6 APLA007861-PA;APLA011572-PA;APLA000215-PA;APLA002552-PA;APLA006361-PA;APLA011430-PA Reactome: R-HSA-1482788 Acyl chain remodelling of PC 5 APLA005749-PA;APLA005748-PA;APLA001975-PA;APLA009079-PA;APLA004469-PA Reactome: R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 3 APLA009848-PA;APLA002288-PA;APLA014272-PA Reactome: R-HSA-937041 IKK complex recruitment mediated by RIP1 2 APLA002288-PA;APLA014272-PA KEGG: 00980+2.5.1.18 Metabolism of xenobiotics by cytochrome P450 1 APLA014577-PA MetaCyc: PWY-7664 Oleate biosynthesis IV (anaerobic) 3 APLA002545-PA;APLA002072-PA;APLA007857-PA MetaCyc: PWY-7184 Pyrimidine deoxyribonucleotides de novo biosynthesis I 11 APLA009372-PA;APLA009142-PA;APLA009849-PA;APLA002995-PA;APLA009005-PA;APLA008494-PA;APLA001267-PA;APLA001202-PA;APLA012574-PA;APLA000359-PA;APLA001305-PA Reactome: R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 8 APLA005017-PA;APLA014003-PA;APLA000806-PA;APLA000940-PA;APLA005264-PA;APLA011005-PA;APLA003055-PA;APLA007872-PA KEGG: 00240+2.7.1.48 Pyrimidine metabolism 2 APLA002052-PA;APLA008439-PA MetaCyc: PWY-7800 Ac/N-end rule pathway 3 APLA008803-PA;APLA010400-PA;APLA003133-PA MetaCyc: PWY-6692 Fe(II) oxidation 1 APLA000133-PA KEGG: 00051+2.7.1.1 Fructose and mannose metabolism 2 APLA002389-PA;APLA001397-PA Reactome: R-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 5 APLA006461-PA;APLA000674-PA;APLA005132-PA;APLA000848-PA;APLA000673-PA MetaCyc: PWY-7921 Protein O-mannosylation I (yeast) 7 APLA008605-PA;APLA008830-PA;APLA010474-PA;APLA007195-PA;APLA007255-PA;APLA012979-PA;APLA013212-PA MetaCyc: PWY-5826 Hypoglycin biosynthesis 3 APLA004285-PA;APLA004293-PA;APLA004294-PA KEGG: 00561+3.1.3.4 Glycerolipid metabolism 1 APLA001595-PA Reactome: R-HSA-8853383 Lysosomal oligosaccharide catabolism 5 APLA008429-PA;APLA008430-PA;APLA001673-PA;APLA001817-PA;APLA004632-PA Reactome: R-HSA-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 1 APLA011128-PA Reactome: R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 2 APLA001793-PA;APLA008115-PA MetaCyc: PWY-6901 Superpathway of glucose and xylose degradation 12 APLA010497-PA;APLA015268-PA;APLA010500-PA;APLA007679-PA;APLA003817-PA;APLA007919-PA;APLA003818-PA;APLA000736-PA;APLA000737-PA;APLA000476-PA;APLA010499-PA;APLA007488-PA MetaCyc: PWY-5353 Arachidonate biosynthesis I (6-desaturase, lower eukaryotes) 2 APLA005258-PA;APLA008114-PA KEGG: 00770+3.6.1.9 Pantothenate and CoA biosynthesis 2 APLA009005-PA;APLA009849-PA KEGG: 00260+1.8.1.4 Glycine, serine and threonine metabolism 1 APLA003939-PA Reactome: R-HSA-2206291 MPS IIIC - Sanfilippo syndrome C 2 APLA000287-PA;APLA000708-PA Reactome: R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 2 APLA003528-PA;APLA011959-PA Reactome: R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 20 APLA009642-PA;APLA009120-PA;APLA011061-PA;APLA005632-PA;APLA001945-PA;APLA007047-PA;APLA013736-PA;APLA003680-PA;APLA007181-PA;APLA012856-PA;APLA008152-PA;APLA013082-PA;APLA015064-PA;APLA007048-PA;APLA005772-PA;APLA007049-PA;APLA004042-PA;APLA004043-PA;APLA002046-PA;APLA004459-PA KEGG: 00720+4.2.1.17+1.1.1.35 Carbon fixation pathways in prokaryotes 4 APLA014896-PA;APLA006178-PA;APLA006174-PA;APLA000468-PA KEGG: 00052+2.7.7.9 Galactose metabolism 1 APLA003021-PA Reactome: R-HSA-202424 Downstream TCR signaling 36 APLA013745-PA;APLA011713-PA;APLA004494-PA;APLA013844-PA;APLA015189-PA;APLA008686-PA;APLA010460-PA;APLA004504-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA000126-PA;APLA008836-PA;APLA008987-PA;APLA001601-PA;APLA013968-PA;APLA005704-PA;APLA013223-PA;APLA015028-PA;APLA012977-PA;APLA002934-PA;APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA006607-PA;APLA014016-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA006943-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA MetaCyc: PWY-6749 CMP-legionaminate biosynthesis I 6 APLA015298-PA;APLA005932-PA;APLA011781-PA;APLA007020-PA;APLA002378-PA;APLA011784-PA Reactome: R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 2 APLA002288-PA;APLA014272-PA Reactome: R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 1 APLA000768-PA KEGG: 00562+3.1.4.11 Inositol phosphate metabolism 5 APLA006557-PA;APLA014442-PA;APLA003808-PA;APLA012536-PA;APLA006554-PA Reactome: R-HSA-450302 activated TAK1 mediates p38 MAPK activation 3 APLA002288-PA;APLA014272-PA;APLA003690-PA KEGG: 00520+5.4.2.3 Amino sugar and nucleotide sugar metabolism 1 APLA002378-PA Reactome: R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 1 APLA001648-PA Reactome: R-HSA-2243919 Crosslinking of collagen fibrils 4 APLA002318-PA;APLA003085-PA;APLA003082-PA;APLA004965-PA Reactome: R-HSA-4570464 SUMOylation of RNA binding proteins 16 APLA004137-PA;APLA006060-PA;APLA015058-PA;APLA001290-PA;APLA011447-PA;APLA010643-PA;APLA003482-PA;APLA002444-PA;APLA000427-PA;APLA009708-PA;APLA002878-PA;APLA005565-PA;APLA011986-PA;APLA000426-PA;APLA005336-PA;APLA005231-PA KEGG: 00400+2.6.1.1 Phenylalanine, tyrosine and tryptophan biosynthesis 2 APLA012983-PA;APLA012145-PA KEGG: 00220+2.6.1.1 Arginine biosynthesis 2 APLA012145-PA;APLA012983-PA Reactome: R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 35 APLA005145-PA;APLA010535-PA;APLA009662-PA;APLA001541-PA;APLA014958-PA;APLA001459-PA;APLA003353-PA;APLA014646-PA;APLA000670-PA;APLA001478-PA;APLA011405-PA;APLA014545-PA;APLA014443-PA;APLA005141-PA;APLA009647-PA;APLA009424-PA;APLA001520-PA;APLA003193-PA;APLA012840-PA;APLA006643-PA;APLA005246-PA;APLA002288-PA;APLA012406-PA;APLA005000-PA;APLA014601-PA;APLA002832-PA;APLA011482-PA;APLA012150-PA;APLA011795-PA;APLA000884-PA;APLA014377-PA;APLA003151-PA;APLA003048-PA;APLA014272-PA;APLA000777-PA Reactome: R-HSA-375280 Amine ligand-binding receptors 1 APLA002322-PA Reactome: R-HSA-388479 Vasopressin-like receptors 3 APLA001150-PA;APLA001458-PA;APLA014391-PA KEGG: 00520+5.3.1.8 Amino sugar and nucleotide sugar metabolism 1 APLA004325-PA KEGG: 04070+3.1.3.36 Phosphatidylinositol signaling system 2 APLA001445-PA;APLA007407-PA Reactome: R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 8 APLA003046-PA;APLA005363-PA;APLA000743-PA;APLA003842-PA;APLA014037-PA;APLA013703-PA;APLA001551-PA;APLA014520-PA KEGG: 00564+3.1.3.4 Glycerophospholipid metabolism 1 APLA001595-PA Reactome: R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 33 APLA008686-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA011713-PA;APLA004504-PA;APLA010460-PA;APLA008987-PA;APLA000126-PA;APLA008836-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA014016-PA;APLA002873-PA;APLA002428-PA;APLA014272-PA;APLA001313-PA;APLA006943-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA Reactome: R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 45 APLA005196-PA;APLA009234-PA;APLA001987-PA;APLA003286-PA;APLA007956-PA;APLA006227-PA;APLA013308-PA;APLA015197-PA;APLA005697-PA;APLA001093-PA;APLA014029-PA;APLA007319-PA;APLA004503-PA;APLA005706-PA;APLA015388-PA;APLA001686-PA;APLA012910-PA;APLA003064-PA;APLA013210-PA;APLA005384-PA;APLA002086-PA;APLA000050-PA;APLA003102-PA;APLA006079-PA;APLA003770-PA;APLA003093-PA;APLA014343-PA;APLA014272-PA;APLA000682-PA;APLA013231-PA;APLA003269-PA;APLA002294-PA;APLA010040-PA;APLA005454-PA;APLA003509-PA;APLA005476-PA;APLA000130-PA;APLA002625-PA;APLA005999-PA;APLA002114-PA;APLA009753-PA;APLA012185-PA;APLA004544-PA;APLA008588-PA;APLA006586-PA Reactome: R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 1 APLA010287-PA KEGG: 00910+6.3.1.2 Nitrogen metabolism 1 APLA000323-PA KEGG: 00511+3.2.1.52 Other glycan degradation 6 APLA001187-PA;APLA012599-PA;APLA006026-PA;APLA002044-PA;APLA003010-PA;APLA010555-PA Reactome: R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family 2 APLA010137-PA;APLA008799-PA KEGG: 00240+1.3.5.2 Pyrimidine metabolism 1 APLA008944-PA Reactome: R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 34 APLA006607-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA001313-PA;APLA014016-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA005756-PA;APLA010347-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA006943-PA;APLA004504-PA;APLA010460-PA;APLA011713-PA;APLA008686-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA008836-PA;APLA000126-PA;APLA006975-PA;APLA011706-PA;APLA000810-PA;APLA008987-PA Reactome: R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 1 APLA014258-PA Reactome: R-HSA-2024101 CS/DS degradation 5 APLA008323-PA;APLA003010-PA;APLA002044-PA;APLA006026-PA;APLA012599-PA KEGG: 00230+1.1.1.205 Purine metabolism 1 APLA003519-PA Reactome: R-HSA-1614517 Sulfide oxidation to sulfate 2 APLA011913-PA;APLA011918-PA KEGG: 00564+2.7.8.11 Glycerophospholipid metabolism 1 APLA010033-PA Reactome: R-HSA-174362 Transport and synthesis of PAPS 1 APLA000768-PA Reactome: R-HSA-8934903 Receptor Mediated Mitophagy 3 APLA014264-PA;APLA012840-PA;APLA005357-PA KEGG: 00630+1.11.1.6 Glyoxylate and dicarboxylate metabolism 14 APLA004174-PA;APLA004175-PA;APLA004171-PA;APLA004172-PA;APLA009588-PA;APLA015327-PA;APLA004582-PA;APLA004183-PA;APLA004184-PA;APLA004588-PA;APLA006341-PA;APLA004182-PA;APLA004173-PA;APLA006339-PA Reactome: R-HSA-69183 Processive synthesis on the lagging strand 8 APLA013151-PA;APLA006690-PA;APLA008659-PA;APLA014513-PA;APLA001691-PA;APLA007371-PA;APLA008612-PA;APLA014841-PA Reactome: R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 1 APLA008080-PA Reactome: R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 3 APLA013736-PA;APLA009882-PA;APLA009642-PA KEGG: 00534+2.4.2.26 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1 APLA008128-PA Reactome: R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 7 APLA006643-PA;APLA002383-PA;APLA014272-PA;APLA007822-PA;APLA002288-PA;APLA009814-PA;APLA014443-PA KEGG: 00020+4.2.1.3 Citrate cycle (TCA cycle) 1 APLA008464-PA MetaCyc: PWY-6124 Inosine-5'-phosphate biosynthesis II 3 APLA007491-PA;APLA008244-PA;APLA008935-PA Reactome: R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 21 APLA000113-PA;APLA003647-PA;APLA009711-PA;APLA007139-PA;APLA005484-PA;APLA012594-PA;APLA012008-PA;APLA013703-PA;APLA014037-PA;APLA005703-PA;APLA001551-PA;APLA002219-PA;APLA012489-PA;APLA004561-PA;APLA009719-PA;APLA003046-PA;APLA005113-PA;APLA001389-PA;APLA000743-PA;APLA007912-PA;APLA008215-PA KEGG: 04660+2.7.10.2 T cell receptor signaling pathway 5 APLA014655-PA;APLA006952-PA;APLA014426-PA;APLA008934-PA;APLA003507-PA Reactome: R-HSA-428930 Thromboxane signalling through TP receptor 1 APLA007917-PA KEGG: 00670+1.5.1.5+3.5.4.9 One carbon pool by folate 2 APLA005730-PA;APLA005741-PA Reactome: R-HSA-182971 EGFR downregulation 5 APLA014272-PA;APLA002288-PA;APLA000454-PA;APLA014546-PA;APLA004850-PA KEGG: 00790+1.1.1.153 Folate biosynthesis 1 APLA011048-PA MetaCyc: PWY-5381 Pyridine nucleotide cycling (plants) 5 APLA012508-PA;APLA002282-PA;APLA003120-PA;APLA012418-PA;APLA002192-PA KEGG: 00340+2.1.1.22 Histidine metabolism 1 APLA012568-PA Reactome: R-HSA-418359 Reduction of cytosolic Ca++ levels 6 APLA012404-PA;APLA004634-PA;APLA004609-PA;APLA004610-PA;APLA012467-PA;APLA010385-PA KEGG: 00760+6.3.1.5 Nicotinate and nicotinamide metabolism 1 APLA002192-PA Reactome: R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 33 APLA014016-PA;APLA014272-PA;APLA002428-PA;APLA002873-PA;APLA001313-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA006943-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA010460-PA;APLA004504-PA;APLA008686-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA011713-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA000126-PA;APLA008836-PA;APLA011706-PA;APLA006975-PA;APLA000810-PA KEGG: 00260+2.1.2.10 Glycine, serine and threonine metabolism 2 APLA005967-PA;APLA006599-PA Reactome: R-HSA-8854214 TBC/RABGAPs 7 APLA012600-PA;APLA009150-PA;APLA007496-PA;APLA007498-PA;APLA011430-PA;APLA003694-PA;APLA014336-PA Reactome: R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin 3 APLA001633-PA;APLA010601-PA;APLA003480-PA MetaCyc: PWY-5523 5,6-dimethylbenzimidazole biosynthesis I (aerobic) 1 APLA014390-PA KEGG: 00623+1.1.1.35 Toluene degradation 4 APLA000468-PA;APLA006174-PA;APLA006178-PA;APLA014896-PA Reactome: R-HSA-8964572 Lipid particle organization 1 APLA011607-PA MetaCyc: PWY-7852 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium) 1 APLA006918-PA MetaCyc: PWY-5690 TCA cycle II (plants and fungi) 14 APLA003089-PA;APLA015489-PA;APLA006254-PA;APLA002458-PA;APLA000357-PA;APLA000684-PA;APLA014289-PA;APLA010449-PA;APLA003262-PA;APLA015456-PA;APLA001878-PA;APLA005378-PA;APLA013330-PA;APLA004846-PA KEGG: 00650+1.3.5.1 Butanoate metabolism 5 APLA003262-PA;APLA015489-PA;APLA006254-PA;APLA013330-PA;APLA000357-PA Reactome: R-HSA-112311 Neurotransmitter clearance 3 APLA003107-PA;APLA007870-PA;APLA006184-PA Reactome: R-HSA-189200 Cellular hexose transport 42 APLA006746-PA;APLA003894-PA;APLA012893-PA;APLA002381-PA;APLA012318-PA;APLA003471-PA;APLA012098-PA;APLA003844-PA;APLA000227-PA;APLA014097-PA;APLA003891-PA;APLA010397-PA;APLA007811-PA;APLA003470-PA;APLA003474-PA;APLA014098-PA;APLA000105-PA;APLA003892-PA;APLA013203-PA;APLA009692-PA;APLA005447-PA;APLA002123-PA;APLA012317-PA;APLA001655-PA;APLA007523-PA;APLA010600-PA;APLA000225-PA;APLA002281-PA;APLA012321-PA;APLA003890-PA;APLA003893-PA;APLA003469-PA;APLA012319-PA;APLA002125-PA;APLA003467-PA;APLA014096-PA;APLA003850-PA;APLA006649-PA;APLA003468-PA;APLA003473-PA;APLA000226-PA;APLA014099-PA Reactome: R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 9 APLA012291-PA;APLA010039-PA;APLA004800-PA;APLA005856-PA;APLA002140-PA;APLA010464-PA;APLA000767-PA;APLA002395-PA;APLA004850-PA Reactome: R-HSA-68962 Activation of the pre-replicative complex 31 APLA001307-PA;APLA009423-PA;APLA008611-PA;APLA007715-PA;APLA010172-PA;APLA008613-PA;APLA001682-PA;APLA011532-PA;APLA002390-PA;APLA003193-PA;APLA008659-PA;APLA013214-PA;APLA014433-PA;APLA006016-PA;APLA005141-PA;APLA008612-PA;APLA014545-PA;APLA006933-PA;APLA007371-PA;APLA001663-PA;APLA001388-PA;APLA014006-PA;APLA006690-PA;APLA014775-PA;APLA013902-PA;APLA008283-PA;APLA014513-PA;APLA010598-PA;APLA002832-PA;APLA006695-PA;APLA008067-PA KEGG: 00270+4.2.1.109 Cysteine and methionine metabolism 1 APLA009072-PA MetaCyc: PWY-7724 Icosapentaenoate biosynthesis III (8-desaturase, mammals) 14 APLA010064-PA;APLA010062-PA;APLA000863-PA;APLA008114-PA;APLA010063-PA;APLA010067-PA;APLA005258-PA;APLA002710-PA;APLA010066-PA;APLA010065-PA;APLA015433-PA;APLA000862-PA;APLA010068-PA;APLA009871-PA Reactome: R-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors 1 APLA014032-PA MetaCyc: PWY-7206 Pyrimidine deoxyribonucleotides dephosphorylation 2 APLA009849-PA;APLA009005-PA KEGG: 00230+2.1.2.2 Purine metabolism 1 APLA005811-PA Reactome: R-HSA-447038 NrCAM interactions 1 APLA002988-PA Reactome: R-HSA-1442490 Collagen degradation 5 APLA003082-PA;APLA007945-PA;APLA003085-PA;APLA010513-PA;APLA005011-PA KEGG: 00240+2.1.3.2 Pyrimidine metabolism 1 APLA002345-PA KEGG: 00240+6.3.5.5 Pyrimidine metabolism 1 APLA002345-PA KEGG: 00030+3.1.1.31 Pentose phosphate pathway 1 APLA000788-PA Reactome: R-HSA-2408522 Selenoamino acid metabolism 8 APLA008703-PA;APLA008833-PA;APLA009586-PA;APLA001592-PA;APLA000131-PA;APLA008681-PA;APLA012591-PA;APLA005781-PA Reactome: R-HSA-156590 Glutathione conjugation 3 APLA008280-PA;APLA008824-PA;APLA014577-PA KEGG: 00230+4.6.1.1 Purine metabolism 8 APLA003037-PA;APLA003039-PA;APLA007417-PA;APLA007416-PA;APLA005245-PA;APLA014278-PA;APLA010134-PA;APLA013400-PA MetaCyc: PWY-7268 NAD/NADP-NADH/NADPH cytosolic interconversion (yeast) 4 APLA013222-PA;APLA001137-PA;APLA005622-PA;APLA011044-PA Reactome: R-HSA-4090294 SUMOylation of intracellular receptors 2 APLA010286-PA;APLA006720-PA MetaCyc: PWY-5109 Fermentation to 2-methylbutanoate 4 APLA006174-PA;APLA006178-PA;APLA014896-PA;APLA000468-PA Reactome: R-HSA-72764 Eukaryotic Translation Termination 73 APLA002294-PA;APLA010040-PA;APLA008225-PA;APLA012226-PA;APLA012986-PA;APLA014343-PA;APLA012510-PA;APLA014272-PA;APLA014985-PA;APLA002288-PA;APLA011333-PA;APLA002114-PA;APLA014444-PA;APLA000210-PA;APLA000130-PA;APLA002625-PA;APLA007375-PA;APLA005454-PA;APLA003509-PA;APLA014046-PA;APLA013308-PA;APLA010469-PA;APLA012910-PA;APLA013210-PA;APLA006618-PA;APLA000605-PA;APLA014384-PA;APLA005706-PA;APLA005697-PA;APLA003014-PA;APLA010999-PA;APLA003269-PA;APLA009495-PA;APLA013231-PA;APLA003770-PA;APLA010605-PA;APLA000682-PA;APLA005265-PA;APLA002086-PA;APLA006079-PA;APLA003102-PA;APLA010013-PA;APLA008588-PA;APLA000488-PA;APLA004075-PA;APLA004544-PA;APLA009753-PA;APLA012185-PA;APLA013392-PA;APLA010839-PA;APLA008614-PA;APLA005404-PA;APLA009213-PA;APLA001622-PA;APLA006227-PA;APLA012911-PA;APLA009149-PA;APLA006379-PA;APLA007492-PA;APLA008766-PA;APLA014107-PA;APLA009234-PA;APLA007956-PA;APLA000956-PA;APLA005384-PA;APLA003064-PA;APLA012609-PA;APLA010171-PA;APLA001686-PA;APLA003217-PA;APLA015388-PA;APLA011066-PA;APLA012151-PA MetaCyc: PWY-7181 Pyrimidine deoxyribonucleosides degradation 1 APLA000366-PA Reactome: R-HSA-6783310 Fanconi Anemia Pathway 45 APLA011663-PA;APLA001948-PA;APLA014750-PA;APLA002288-PA;APLA012660-PA;APLA001892-PA;APLA005954-PA;APLA014473-PA;APLA013374-PA;APLA001536-PA;APLA012775-PA;APLA008920-PA;APLA011655-PA;APLA002832-PA;APLA000681-PA;APLA005996-PA;APLA006049-PA;APLA008179-PA;APLA014272-PA;APLA003914-PA;APLA013862-PA;APLA011947-PA;APLA007601-PA;APLA014822-PA;APLA004778-PA;APLA004154-PA;APLA012450-PA;APLA001541-PA;APLA007979-PA;APLA013670-PA;APLA004835-PA;APLA000721-PA;APLA004319-PA;APLA006038-PA;APLA010971-PA;APLA001897-PA;APLA014545-PA;APLA011035-PA;APLA007592-PA;APLA009573-PA;APLA011159-PA;APLA008603-PA;APLA006346-PA;APLA005141-PA;APLA003193-PA Reactome: R-HSA-947581 Molybdenum cofactor biosynthesis 5 APLA001630-PA;APLA009260-PA;APLA008007-PA;APLA008006-PA;APLA001255-PA KEGG: 00051+5.3.1.8 Fructose and mannose metabolism 1 APLA004325-PA Reactome: R-HSA-110329 Cleavage of the damaged pyrimidine 4 APLA010076-PA;APLA001632-PA;APLA006748-PA;APLA001208-PA MetaCyc: PWY-6908 Thiamine diphosphate biosynthesis IV (eukaryotes) 1 APLA005503-PA MetaCyc: PWY-6863 Pyruvate fermentation to hexanol (engineered) 4 APLA000468-PA;APLA006174-PA;APLA006178-PA;APLA014896-PA MetaCyc: PWY-5392 Reductive TCA cycle II 9 APLA003089-PA;APLA002458-PA;APLA010449-PA;APLA014289-PA;APLA000684-PA;APLA001878-PA;APLA015456-PA;APLA005378-PA;APLA004846-PA Reactome: R-HSA-5632684 Hedgehog 'on' state 36 APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA000126-PA;APLA008836-PA;APLA009411-PA;APLA008987-PA;APLA004504-PA;APLA010460-PA;APLA011713-PA;APLA008686-PA;APLA013844-PA;APLA015189-PA;APLA007972-PA;APLA004494-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA005756-PA;APLA010347-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA006943-PA;APLA001313-PA;APLA002428-PA;APLA014272-PA;APLA002873-PA;APLA014016-PA;APLA015028-PA;APLA013223-PA;APLA011623-PA;APLA012977-PA KEGG: 00670+2.1.2.3 One carbon pool by folate 1 APLA008244-PA Reactome: R-HSA-4549356 Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 1 APLA002213-PA Reactome: R-HSA-5696395 Formation of Incision Complex in GG-NER 19 APLA001624-PA;APLA000830-PA;APLA000551-PA;APLA001661-PA;APLA004572-PA;APLA003193-PA;APLA014272-PA;APLA006346-PA;APLA005141-PA;APLA001596-PA;APLA009703-PA;APLA014545-PA;APLA014197-PA;APLA002288-PA;APLA012424-PA;APLA003279-PA;APLA002832-PA;APLA010986-PA;APLA000879-PA MetaCyc: PWY-7409 Phospholipid remodeling (phosphatidylethanolamine, yeast) 7 APLA001975-PA;APLA004469-PA;APLA009078-PA;APLA009079-PA;APLA012384-PA;APLA005749-PA;APLA005748-PA Reactome: R-HSA-189085 Digestion of dietary carbohydrate 59 APLA010716-PA;APLA009677-PA;APLA010778-PA;APLA004699-PA;APLA004324-PA;APLA000660-PA;APLA001295-PA;APLA014159-PA;APLA009926-PA;APLA007850-PA;APLA005049-PA;APLA007650-PA;APLA001296-PA;APLA014158-PA;APLA002520-PA;APLA004331-PA;APLA011813-PA;APLA001856-PA;APLA007660-PA;APLA010945-PA;APLA010572-PA;APLA001425-PA;APLA009928-PA;APLA001185-PA;APLA005659-PA;APLA000900-PA;APLA013367-PA;APLA010717-PA;APLA007662-PA;APLA007993-PA;APLA007914-PA;APLA014157-PA;APLA010776-PA;APLA010777-PA;APLA001795-PA;APLA014434-PA;APLA009923-PA;APLA003488-PA;APLA007656-PA;APLA003546-PA;APLA009927-PA;APLA009924-PA;APLA007661-PA;APLA007645-PA;APLA009922-PA;APLA002575-PA;APLA001937-PA;APLA007647-PA;APLA003634-PA;APLA003813-PA;APLA009925-PA;APLA000663-PA;APLA010573-PA;APLA007851-PA;APLA011294-PA;APLA005048-PA;APLA010633-PA;APLA011526-PA;APLA004625-PA Reactome: R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 3 APLA014272-PA;APLA007487-PA;APLA002288-PA MetaCyc: PWY-8053 Anandamide biosynthesis II 15 APLA009816-PA;APLA005748-PA;APLA002667-PA;APLA005749-PA;APLA004147-PA;APLA014471-PA;APLA012384-PA;APLA009078-PA;APLA004469-PA;APLA009079-PA;APLA008027-PA;APLA000543-PA;APLA001595-PA;APLA012686-PA;APLA001975-PA MetaCyc: PWY-7606 Docosahexaenoate biosynthesis III (6-desaturase, mammals) 8 APLA006178-PA;APLA006174-PA;APLA005258-PA;APLA003250-PA;APLA014896-PA;APLA013190-PA;APLA008114-PA;APLA000468-PA MetaCyc: PWY-6100 L-carnitine biosynthesis 1 APLA009139-PA KEGG: 00900+2.3.3.10 Terpenoid backbone biosynthesis 1 APLA007166-PA Reactome: R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 25 APLA014272-PA;APLA005176-PA;APLA008278-PA;APLA006607-PA;APLA005175-PA;APLA008497-PA;APLA008956-PA;APLA009966-PA;APLA008509-PA;APLA005953-PA;APLA000606-PA;APLA001380-PA;APLA001514-PA;APLA005011-PA;APLA011837-PA;APLA006117-PA;APLA014713-PA;APLA002675-PA;APLA005949-PA;APLA002288-PA;APLA013383-PA;APLA007945-PA;APLA006113-PA;APLA007136-PA;APLA001407-PA Reactome: R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription 2 APLA008489-PA;APLA008490-PA Reactome: R-HSA-196757 Metabolism of folate and pterines 8 APLA011535-PA;APLA005741-PA;APLA005950-PA;APLA005730-PA;APLA003860-PA;APLA000499-PA;APLA008595-PA;APLA012570-PA Reactome: R-HSA-186797 Signaling by PDGF 4 APLA003082-PA;APLA013062-PA;APLA003085-PA;APLA013061-PA MetaCyc: PWY-7199 Pyrimidine deoxyribonucleosides salvage 3 APLA008494-PA;APLA000366-PA;APLA009142-PA Reactome: R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1 APLA014601-PA Reactome: R-HSA-9037629 Lewis blood group biosynthesis 6 APLA012836-PA;APLA013397-PA;APLA000079-PA;APLA002480-PA;APLA013146-PA;APLA013765-PA Reactome: R-HSA-173599 Formation of the active cofactor, UDP-glucuronate 2 APLA005458-PA;APLA003021-PA MetaCyc: PWY-7039 Phosphatidate metabolism, as a signaling molecule 11 APLA006190-PA;APLA006554-PA;APLA012308-PA;APLA011460-PA;APLA006557-PA;APLA011740-PA;APLA003808-PA;APLA012536-PA;APLA013224-PA;APLA014442-PA;APLA011921-PA Reactome: R-HSA-1660662 Glycosphingolipid metabolism 20 APLA008574-PA;APLA003237-PA;APLA012329-PA;APLA003566-PA;APLA002044-PA;APLA014467-PA;APLA004223-PA;APLA012328-PA;APLA012402-PA;APLA012599-PA;APLA005540-PA;APLA004208-PA;APLA004579-PA;APLA008998-PA;APLA007350-PA;APLA012114-PA;APLA004099-PA;APLA002142-PA;APLA006026-PA;APLA003010-PA Reactome: R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated 3 APLA010601-PA;APLA003480-PA;APLA001633-PA Reactome: R-HSA-5545483 Defective Mismatch Repair Associated With MLH1 1 APLA005929-PA KEGG: 00450+2.7.9.3 Selenocompound metabolism 1 APLA014778-PA Reactome: R-HSA-5654727 Negative regulation of FGFR2 signaling 3 APLA002288-PA;APLA002140-PA;APLA014272-PA KEGG: 00670+2.1.1.45 One carbon pool by folate 2 APLA008494-PA;APLA009142-PA Reactome: R-HSA-1912420 Pre-NOTCH Processing in Golgi 2 APLA012467-PA;APLA011927-PA MetaCyc: PWY-6724 Starch degradation II 2 APLA004011-PA;APLA004009-PA Reactome: R-HSA-196843 Vitamin B2 (riboflavin) metabolism 1 APLA014390-PA Reactome: R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 95 APLA012609-PA;APLA000135-PA;APLA003064-PA;APLA008510-PA;APLA000956-PA;APLA005384-PA;APLA012151-PA;APLA000516-PA;APLA001686-PA;APLA015388-PA;APLA011066-PA;APLA003217-PA;APLA009847-PA;APLA007492-PA;APLA006379-PA;APLA008766-PA;APLA009149-PA;APLA006227-PA;APLA001622-PA;APLA010016-PA;APLA012911-PA;APLA002360-PA;APLA012684-PA;APLA007956-PA;APLA014107-PA;APLA009234-PA;APLA004544-PA;APLA012185-PA;APLA009753-PA;APLA007609-PA;APLA000488-PA;APLA004075-PA;APLA008588-PA;APLA010013-PA;APLA010020-PA;APLA009213-PA;APLA005404-PA;APLA008614-PA;APLA013392-PA;APLA002087-PA;APLA010839-PA;APLA006848-PA;APLA009495-PA;APLA013231-PA;APLA010999-PA;APLA003269-PA;APLA006079-PA;APLA003102-PA;APLA002086-PA;APLA005265-PA;APLA010605-PA;APLA000682-PA;APLA003770-PA;APLA013210-PA;APLA012910-PA;APLA001952-PA;APLA009226-PA;APLA003234-PA;APLA007710-PA;APLA005697-PA;APLA014914-PA;APLA003014-PA;APLA014384-PA;APLA005706-PA;APLA006618-PA;APLA000605-PA;APLA013308-PA;APLA014046-PA;APLA010469-PA;APLA014444-PA;APLA002114-PA;APLA011333-PA;APLA002288-PA;APLA012978-PA;APLA003509-PA;APLA005454-PA;APLA001067-PA;APLA007375-PA;APLA005637-PA;APLA000210-PA;APLA000130-PA;APLA002625-PA;APLA009951-PA;APLA012226-PA;APLA008225-PA;APLA010040-PA;APLA002294-PA;APLA013278-PA;APLA009971-PA;APLA005893-PA;APLA014985-PA;APLA014272-PA;APLA012986-PA;APLA014343-PA;APLA000132-PA Reactome: R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 29 APLA004383-PA;APLA015416-PA;APLA002191-PA;APLA010197-PA;APLA009417-PA;APLA010198-PA;APLA003496-PA;APLA001953-PA;APLA012544-PA;APLA015031-PA;APLA013945-PA;APLA004838-PA;APLA004837-PA;APLA011047-PA;APLA013357-PA;APLA002551-PA;APLA010596-PA;APLA013359-PA;APLA003036-PA;APLA014850-PA;APLA013639-PA;APLA007858-PA;APLA012338-PA;APLA014998-PA;APLA008973-PA;APLA008446-PA;APLA014048-PA;APLA010196-PA;APLA000839-PA KEGG: 00230+6.3.3.1 Purine metabolism 1 APLA005811-PA Reactome: R-HSA-69231 Cyclin D associated events in G1 8 APLA011831-PA;APLA002288-PA;APLA001596-PA;APLA010545-PA;APLA014272-PA;APLA008095-PA;APLA006607-PA;APLA008103-PA KEGG: 00770+2.7.8.7 Pantothenate and CoA biosynthesis 1 APLA001971-PA KEGG: 00561+2.3.1.51 Glycerolipid metabolism 5 APLA014471-PA;APLA004147-PA;APLA000543-PA;APLA008027-PA;APLA012686-PA Reactome: R-HSA-8941284 RUNX2 regulates chondrocyte maturation 2 APLA008489-PA;APLA008490-PA Reactome: R-HSA-1483226 Synthesis of PI 1 APLA010033-PA MetaCyc: PWY-7234 Inosine-5'-phosphate biosynthesis III 3 APLA008935-PA;APLA007491-PA;APLA008244-PA Reactome: R-HSA-1989781 PPARA activates gene expression 36 APLA010275-PA;APLA006662-PA;APLA013198-PA;APLA010662-PA;APLA012425-PA;APLA000043-PA;APLA008653-PA;APLA008217-PA;APLA012596-PA;APLA008274-PA;APLA005632-PA;APLA004448-PA;APLA008186-PA;APLA009433-PA;APLA001514-PA;APLA006663-PA;APLA005955-PA;APLA002451-PA;APLA007887-PA;APLA003680-PA;APLA012579-PA;APLA006664-PA;APLA003383-PA;APLA004447-PA;APLA006660-PA;APLA011837-PA;APLA005449-PA;APLA010312-PA;APLA000204-PA;APLA004459-PA;APLA015064-PA;APLA007823-PA;APLA008152-PA;APLA012607-PA;APLA008337-PA;APLA007166-PA MetaCyc: PWY-6708 Ubiquinol-8 biosynthesis (prokaryotic) 1 APLA002418-PA MetaCyc: PWY-7343 UDP-alpha-D-glucose biosynthesis I 1 APLA003021-PA Reactome: R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 1 APLA007954-PA KEGG: 00010+6.2.1.1 Glycolysis / Gluconeogenesis 2 APLA006387-PA;APLA008135-PA Reactome: R-HSA-5625740 RHO GTPases activate PKNs 4 APLA011959-PA;APLA013745-PA;APLA002092-PA;APLA003528-PA Reactome: R-HSA-8875656 MET receptor recycling 2 APLA009992-PA;APLA003694-PA KEGG: 00550+2.4.1.227 Peptidoglycan biosynthesis 1 APLA009515-PA Reactome: R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated 3 APLA010601-PA;APLA003480-PA;APLA001633-PA KEGG: 00860+1.3.3.3 Porphyrin and chlorophyll metabolism 1 APLA007924-PA Reactome: R-HSA-190873 Gap junction degradation 3 APLA010150-PA;APLA001793-PA;APLA008767-PA MetaCyc: PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA 1 APLA003939-PA Reactome: R-HSA-68949 Orc1 removal from chromatin 52 APLA006607-PA;APLA014433-PA;APLA002428-PA;APLA014272-PA;APLA002390-PA;APLA002873-PA;APLA001313-PA;APLA014016-PA;APLA015028-PA;APLA013223-PA;APLA008611-PA;APLA012977-PA;APLA010172-PA;APLA007715-PA;APLA007463-PA;APLA005719-PA;APLA010598-PA;APLA012593-PA;APLA005756-PA;APLA010347-PA;APLA006695-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA006943-PA;APLA014775-PA;APLA004504-PA;APLA010460-PA;APLA013214-PA;APLA006933-PA;APLA011713-PA;APLA001307-PA;APLA011532-PA;APLA008686-PA;APLA001682-PA;APLA008613-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA001601-PA;APLA005704-PA;APLA008067-PA;APLA013968-PA;APLA001388-PA;APLA000126-PA;APLA008836-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA001663-PA;APLA008987-PA;APLA013902-PA Reactome: R-HSA-445144 Signal transduction by L1 2 APLA002140-PA;APLA012840-PA Reactome: R-HSA-70895 Branched-chain amino acid catabolism 7 APLA000040-PA;APLA006559-PA;APLA006327-PA;APLA005019-PA;APLA014528-PA;APLA003939-PA;APLA005020-PA Reactome: R-HSA-202670 ERKs are inactivated 1 APLA002140-PA Reactome: R-HSA-72187 mRNA 3'-end processing 24 APLA006974-PA;APLA004737-PA;APLA015322-PA;APLA005063-PA;APLA012186-PA;APLA011282-PA;APLA014430-PA;APLA012013-PA;APLA001716-PA;APLA009973-PA;APLA012011-PA;APLA009489-PA;APLA014042-PA;APLA002938-PA;APLA010675-PA;APLA000465-PA;APLA002937-PA;APLA014338-PA;APLA009518-PA;APLA003076-PA;APLA010315-PA;APLA006970-PA;APLA003898-PA;APLA001717-PA KEGG: 00230+6.3.5.2 Purine metabolism 2 APLA005740-PA;APLA005738-PA Reactome: R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 3 APLA011318-PA;APLA014103-PA;APLA012476-PA KEGG: 00010+2.7.1.1 Glycolysis / Gluconeogenesis 2 APLA001397-PA;APLA002389-PA KEGG: 00230+6.3.2.6 Purine metabolism 1 APLA008935-PA KEGG: 00480+1.1.1.49 Glutathione metabolism 1 APLA005622-PA KEGG: 00062+4.2.1.134 Fatty acid elongation 2 APLA005258-PA;APLA008114-PA KEGG: 00970+6.1.1.2 Aminoacyl-tRNA biosynthesis 2 APLA013060-PA;APLA011328-PA Reactome: R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 6 APLA002937-PA;APLA015233-PA;APLA002938-PA;APLA005894-PA;APLA008641-PA;APLA010637-PA KEGG: 00640+6.4.1.2 Propanoate metabolism 1 APLA013496-PA Reactome: R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 4 APLA003653-PA;APLA010182-PA;APLA003348-PA;APLA009113-PA MetaCyc: PWY-6482 Diphthamide biosynthesis I (archaea) 3 APLA005402-PA;APLA012901-PA;APLA009467-PA Reactome: R-HSA-5083630 Defective LFNG causes SCDO3 1 APLA011927-PA KEGG: 00310+4.2.1.17+1.1.1.35 Lysine degradation 4 APLA000468-PA;APLA014896-PA;APLA006178-PA;APLA006174-PA Reactome: R-HSA-1660499 Synthesis of PIPs at the plasma membrane 6 APLA003527-PA;APLA012421-PA;APLA001445-PA;APLA002528-PA;APLA011572-PA;APLA008598-PA Reactome: R-HSA-8964616 G beta:gamma signalling through CDC42 1 APLA004850-PA Reactome: R-HSA-3214842 HDMs demethylate histones 4 APLA003657-PA;APLA006786-PA;APLA013591-PA;APLA000552-PA Reactome: R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 4 APLA005893-PA;APLA007710-PA;APLA009847-PA;APLA009226-PA Reactome: R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 3 APLA004089-PA;APLA002288-PA;APLA014272-PA Reactome: R-HSA-162699 Synthesis of dolichyl-phosphate mannose 2 APLA013212-PA;APLA006452-PA Reactome: R-HSA-203615 eNOS activation 1 APLA011048-PA Reactome: R-HSA-2129379 Molecules associated with elastic fibres 2 APLA009721-PA;APLA012200-PA MetaCyc: PWY-5839 Menaquinol-7 biosynthesis 1 APLA015235-PA KEGG: 04070+2.7.4.24+2.7.4.21 Phosphatidylinositol signaling system 1 APLA001574-PA KEGG: 00051+5.4.2.8 Fructose and mannose metabolism 1 APLA009743-PA MetaCyc: PWY-5083 NAD/NADH phosphorylation and dephosphorylation 2 APLA013222-PA;APLA011044-PA Reactome: R-HSA-4608870 Asymmetric localization of PCP proteins 33 APLA014016-PA;APLA001313-PA;APLA002428-PA;APLA014272-PA;APLA002873-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA010347-PA;APLA005756-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA006943-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA004504-PA;APLA010460-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA008686-PA;APLA011713-PA;APLA013968-PA;APLA005704-PA;APLA001601-PA;APLA008987-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA Reactome: R-HSA-9630222 Defective NTHL1 substrate binding 1 APLA001208-PA Reactome: R-HSA-8863795 Downregulation of ERBB2 signaling 5 APLA009848-PA;APLA006305-PA;APLA012828-PA;APLA014272-PA;APLA002288-PA MetaCyc: PWY-8013 UDP-N-acetyl-D-galactosamine biosynthesis III 2 APLA007020-PA;APLA014015-PA KEGG: 00521+3.1.3.25 Streptomycin biosynthesis 2 APLA002096-PA;APLA008242-PA Reactome: R-HSA-982772 Growth hormone receptor signaling 3 APLA007945-PA;APLA003843-PA;APLA002140-PA MetaCyc: PWY-5789 3-hydroxypropanoate/4-hydroxybutanate cycle 12 APLA008850-PA;APLA002692-PA;APLA006178-PA;APLA006174-PA;APLA007201-PA;APLA010823-PA;APLA013496-PA;APLA000468-PA;APLA013219-PA;APLA010822-PA;APLA014896-PA;APLA014966-PA KEGG: 04150+2.7.1.153 mTOR signaling pathway 1 APLA002528-PA Reactome: R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 2 APLA014272-PA;APLA002288-PA MetaCyc: PWY-7817 Type I lipoteichoic acid biosynthesis (S. aureus) 8 APLA013224-PA;APLA003021-PA;APLA011921-PA;APLA012308-PA;APLA003095-PA;APLA006190-PA;APLA011740-PA;APLA002731-PA Reactome: R-HSA-204626 Hypusine synthesis from eIF5A-lysine 2 APLA007221-PA;APLA009762-PA KEGG: 00562+2.7.1.153 Inositol phosphate metabolism 1 APLA002528-PA Reactome: R-HSA-916853 Degradation of GABA 1 APLA003896-PA Reactome: R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 41 APLA009417-PA;APLA015058-PA;APLA010643-PA;APLA002883-PA;APLA004639-PA;APLA001953-PA;APLA013547-PA;APLA013357-PA;APLA012338-PA;APLA007858-PA;APLA010196-PA;APLA014048-PA;APLA008446-PA;APLA003480-PA;APLA014850-PA;APLA014772-PA;APLA009660-PA;APLA010198-PA;APLA015416-PA;APLA004383-PA;APLA010197-PA;APLA015031-PA;APLA014307-PA;APLA001833-PA;APLA002135-PA;APLA001633-PA;APLA013359-PA;APLA014679-PA;APLA001351-PA;APLA005242-PA;APLA000427-PA;APLA002856-PA;APLA002551-PA;APLA010596-PA;APLA007552-PA;APLA014998-PA;APLA001683-PA;APLA002909-PA;APLA011986-PA;APLA000426-PA;APLA002859-PA Reactome: R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine 1 APLA010076-PA KEGG: 00280+2.6.1.42 Valine, leucine and isoleucine degradation 1 APLA006327-PA MetaCyc: PWY-7936 Psilocybin biosynthesis 15 APLA001625-PA;APLA010883-PA;APLA001626-PA;APLA013064-PA;APLA006962-PA;APLA006961-PA;APLA000028-PA;APLA008220-PA;APLA000031-PA;APLA000030-PA;APLA011409-PA;APLA005504-PA;APLA004376-PA;APLA000034-PA;APLA007689-PA Reactome: R-HSA-418886 Netrin mediated repulsion signals 1 APLA008267-PA KEGG: 00230+3.6.1.9 Purine metabolism 2 APLA009849-PA;APLA009005-PA KEGG: 00600+2.4.1.80 Sphingolipid metabolism 1 APLA012402-PA Reactome: R-HSA-4641263 Regulation of FZD by ubiquitination 2 APLA002288-PA;APLA014272-PA Reactome: R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1 APLA015057-PA Reactome: R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 3 APLA014683-PA;APLA001574-PA;APLA003180-PA Reactome: R-HSA-1433557 Signaling by SCF-KIT 2 APLA012421-PA;APLA008934-PA MetaCyc: PWY-8072 Alanine racemization 1 APLA014952-PA MetaCyc: PWY-5532 Nucleoside and nucleotide degradation (archaea) 3 APLA000262-PA;APLA013738-PA;APLA001272-PA MetaCyc: PWY-7226 Guanosine deoxyribonucleotides de novo biosynthesis I 5 APLA009372-PA;APLA001267-PA;APLA012574-PA;APLA000359-PA;APLA002995-PA MetaCyc: PWY-882 L-ascorbate biosynthesis I (L-galactose pathway) 2 APLA004325-PA;APLA009743-PA Reactome: R-HSA-5628897 TP53 Regulates Metabolic Genes 35 APLA002724-PA;APLA014094-PA;APLA010301-PA;APLA009150-PA;APLA014015-PA;APLA012224-PA;APLA007496-PA;APLA003047-PA;APLA010535-PA;APLA009658-PA;APLA010175-PA;APLA008732-PA;APLA013702-PA;APLA002332-PA;APLA008339-PA;APLA013308-PA;APLA010056-PA;APLA005633-PA;APLA009856-PA;APLA014601-PA;APLA009642-PA;APLA014026-PA;APLA013736-PA;APLA008157-PA;APLA002692-PA;APLA012202-PA;APLA003528-PA;APLA000822-PA;APLA014130-PA;APLA000601-PA;APLA013701-PA;APLA009758-PA;APLA007498-PA;APLA011959-PA;APLA005545-PA Reactome: R-HSA-879415 Advanced glycosylation endproduct receptor signaling 4 APLA002140-PA;APLA002360-PA;APLA007932-PA;APLA009488-PA KEGG: 00790+1.5.1.3 Folate biosynthesis 1 APLA012570-PA KEGG: 00564+3.1.1.32 Glycerophospholipid metabolism 3 APLA002539-PA;APLA012865-PA;APLA008047-PA Reactome: R-HSA-445355 Smooth Muscle Contraction 7 APLA001410-PA;APLA001413-PA;APLA015356-PA;APLA008917-PA;APLA005271-PA;APLA005272-PA;APLA004212-PA Reactome: R-HSA-9017802 Noncanonical activation of NOTCH3 3 APLA007136-PA;APLA005953-PA;APLA014713-PA MetaCyc: PWY-7918 Protein N-glycosylation processing phase (yeast) 1 APLA002968-PA Reactome: R-HSA-500753 Pyrimidine biosynthesis 4 APLA002345-PA;APLA006685-PA;APLA004501-PA;APLA008944-PA KEGG: 00982+1.1.1.1 Drug metabolism - cytochrome P450 1 APLA001970-PA Reactome: R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 34 APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA008987-PA;APLA004504-PA;APLA010460-PA;APLA012166-PA;APLA011713-PA;APLA008686-PA;APLA004494-PA;APLA013844-PA;APLA015189-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA005756-PA;APLA010347-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA006943-PA;APLA001313-PA;APLA002428-PA;APLA002873-PA;APLA014272-PA;APLA014016-PA;APLA013223-PA;APLA015028-PA;APLA012977-PA Reactome: R-HSA-69481 G2/M Checkpoints 33 APLA010347-PA;APLA005756-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA006943-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA014016-PA;APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA013968-PA;APLA005704-PA;APLA001601-PA;APLA008987-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA010460-PA;APLA004504-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA008686-PA;APLA011713-PA KEGG: 00720+6.3.4.3 Carbon fixation pathways in prokaryotes 1 APLA005730-PA Reactome: R-HSA-5693548 Sensing of DNA Double Strand Breaks 2 APLA006643-PA;APLA014443-PA Reactome: R-HSA-159740 Gamma-carboxylation of protein precursors 2 APLA003042-PA;APLA003040-PA Reactome: R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 17 APLA012594-PA;APLA009711-PA;APLA005484-PA;APLA007139-PA;APLA000113-PA;APLA003046-PA;APLA001389-PA;APLA000743-PA;APLA005113-PA;APLA008215-PA;APLA014037-PA;APLA012008-PA;APLA013703-PA;APLA001551-PA;APLA002219-PA;APLA005703-PA;APLA004561-PA MetaCyc: PWY-7220 Adenosine deoxyribonucleotides de novo biosynthesis II 5 APLA000359-PA;APLA001267-PA;APLA012574-PA;APLA009372-PA;APLA002995-PA KEGG: 00010+5.3.1.9 Glycolysis / Gluconeogenesis 1 APLA014015-PA Reactome: R-HSA-8851805 MET activates RAS signaling 1 APLA001827-PA Reactome: R-HSA-167287 HIV elongation arrest and recovery 21 APLA006924-PA;APLA000547-PA;APLA008112-PA;APLA006899-PA;APLA014520-PA;APLA011795-PA;APLA003187-PA;APLA014999-PA;APLA003048-PA;APLA008108-PA;APLA009185-PA;APLA000743-PA;APLA014024-PA;APLA015000-PA;APLA003842-PA;APLA003046-PA;APLA005321-PA;APLA001456-PA;APLA001551-PA;APLA014037-PA;APLA013703-PA MetaCyc: PWY-6483 Ceramide degradation (generic) 1 APLA004099-PA Reactome: R-HSA-674695 RNA Polymerase II Pre-transcription Events 46 APLA008984-PA;APLA003187-PA;APLA008108-PA;APLA000547-PA;APLA007145-PA;APLA007972-PA;APLA014646-PA;APLA000670-PA;APLA008112-PA;APLA001478-PA;APLA006899-PA;APLA001624-PA;APLA001551-PA;APLA013703-PA;APLA015000-PA;APLA005145-PA;APLA008519-PA;APLA014024-PA;APLA000743-PA;APLA002938-PA;APLA009107-PA;APLA001456-PA;APLA014999-PA;APLA009703-PA;APLA014520-PA;APLA001596-PA;APLA011795-PA;APLA005278-PA;APLA003048-PA;APLA011482-PA;APLA009092-PA;APLA006924-PA;APLA012150-PA;APLA002009-PA;APLA000879-PA;APLA012883-PA;APLA010986-PA;APLA014037-PA;APLA003279-PA;APLA003842-PA;APLA008290-PA;APLA009185-PA;APLA005246-PA;APLA002937-PA;APLA003046-PA;APLA005321-PA MetaCyc: PWY-7782 Plasmalogen biosynthesis 15 APLA001595-PA;APLA000546-PA;APLA012686-PA;APLA000545-PA;APLA002536-PA;APLA001864-PA;APLA000540-PA;APLA003949-PA;APLA004147-PA;APLA000726-PA;APLA014471-PA;APLA000543-PA;APLA000704-PA;APLA000539-PA;APLA008027-PA KEGG: 00785+2.3.1.181 Lipoic acid metabolism 3 APLA004383-PA;APLA002544-PA;APLA009991-PA MetaCyc: PWY-7854 Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered) 2 APLA013190-PA;APLA003250-PA KEGG: 00380+1.13.11.11 Tryptophan metabolism 1 APLA006567-PA KEGG: 00983+1.1.1.205 Drug metabolism - other enzymes 1 APLA003519-PA Reactome: R-HSA-164843 2-LTR circle formation 4 APLA007938-PA;APLA012887-PA;APLA002908-PA;APLA004738-PA MetaCyc: PWY-6969 TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) 15 APLA002458-PA;APLA000357-PA;APLA000684-PA;APLA010449-PA;APLA014289-PA;APLA003089-PA;APLA015489-PA;APLA006254-PA;APLA005378-PA;APLA013330-PA;APLA004846-PA;APLA001137-PA;APLA003262-PA;APLA015456-PA;APLA001878-PA KEGG: 00250+2.6.1.19 Alanine, aspartate and glutamate metabolism 1 APLA003896-PA KEGG: 00710+1.1.1.37 Carbon fixation in photosynthetic organisms 3 APLA015456-PA;APLA005378-PA;APLA000684-PA Reactome: R-HSA-913709 O-linked glycosylation of mucins 16 APLA004210-PA;APLA010140-PA;APLA013212-PA;APLA000913-PA;APLA014873-PA;APLA001816-PA;APLA009102-PA;APLA010141-PA;APLA005648-PA;APLA012068-PA;APLA000081-PA;APLA013393-PA;APLA010991-PA;APLA012810-PA;APLA004823-PA;APLA002373-PA KEGG: 00010+2.7.1.11 Glycolysis / Gluconeogenesis 2 APLA013706-PA;APLA013705-PA Reactome: R-HSA-110357 Displacement of DNA glycosylase by APEX1 5 APLA001632-PA;APLA006748-PA;APLA001208-PA;APLA010076-PA;APLA000563-PA KEGG: 00250+3.5.1.1 Alanine, aspartate and glutamate metabolism 3 APLA004306-PA;APLA005073-PA;APLA004354-PA Reactome: R-HSA-73621 Pyrimidine catabolism 7 APLA000440-PA;APLA001860-PA;APLA002704-PA;APLA006685-PA;APLA001862-PA;APLA001272-PA;APLA014913-PA KEGG: 00564+3.1.1.4+3.1.1.5 Glycerophospholipid metabolism 1 APLA001975-PA KEGG: 00480+2.5.1.16 Glutathione metabolism 2 APLA000590-PA;APLA003859-PA KEGG: 00531+3.2.1.52 Glycosaminoglycan degradation 6 APLA001187-PA;APLA012599-PA;APLA006026-PA;APLA002044-PA;APLA010555-PA;APLA003010-PA KEGG: 00790+1.14.16.1 Folate biosynthesis 1 APLA006614-PA Reactome: R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 4 APLA001632-PA;APLA006748-PA;APLA001208-PA;APLA010076-PA Reactome: R-HSA-73614 Pyrimidine salvage 4 APLA008439-PA;APLA001272-PA;APLA000366-PA;APLA002052-PA Reactome: R-HSA-1236394 Signaling by ERBB4 2 APLA003750-PA;APLA012797-PA Reactome: R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 14 APLA009217-PA;APLA009349-PA;APLA011670-PA;APLA008961-PA;APLA007969-PA;APLA000266-PA;APLA000049-PA;APLA000110-PA;APLA014519-PA;APLA011505-PA;APLA014716-PA;APLA006053-PA;APLA007959-PA;APLA005863-PA Reactome: R-HSA-203927 MicroRNA (miRNA) biogenesis 16 APLA010009-PA;APLA013703-PA;APLA012199-PA;APLA014037-PA;APLA008660-PA;APLA001551-PA;APLA003046-PA;APLA003842-PA;APLA011610-PA;APLA003047-PA;APLA000743-PA;APLA013702-PA;APLA013701-PA;APLA014130-PA;APLA014520-PA;APLA014357-PA Reactome: R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 18 APLA006607-PA;APLA014272-PA;APLA008278-PA;APLA005176-PA;APLA008956-PA;APLA005175-PA;APLA001514-PA;APLA000606-PA;APLA001380-PA;APLA009503-PA;APLA011837-PA;APLA009504-PA;APLA002288-PA;APLA005949-PA;APLA009499-PA;APLA002675-PA;APLA001407-PA;APLA013383-PA Reactome: R-HSA-111465 Apoptotic cleavage of cellular proteins 2 APLA005120-PA;APLA010601-PA MetaCyc: PWY-6435 4-hydroxybenzoate biosynthesis III (plants) 4 APLA006178-PA;APLA014896-PA;APLA006174-PA;APLA000468-PA MetaCyc: PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA 5 APLA005733-PA;APLA003091-PA;APLA007913-PA;APLA011349-PA;APLA003939-PA Reactome: R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 28 APLA008290-PA;APLA015000-PA;APLA005145-PA;APLA003842-PA;APLA003279-PA;APLA005246-PA;APLA000743-PA;APLA003046-PA;APLA000879-PA;APLA001551-PA;APLA012883-PA;APLA013703-PA;APLA014037-PA;APLA010986-PA;APLA007145-PA;APLA011482-PA;APLA014646-PA;APLA012150-PA;APLA006899-PA;APLA001478-PA;APLA001624-PA;APLA000670-PA;APLA008112-PA;APLA014999-PA;APLA014520-PA;APLA001596-PA;APLA009703-PA;APLA008108-PA KEGG: 00010+5.4.2.11 Glycolysis / Gluconeogenesis 2 APLA004744-PA;APLA006779-PA MetaCyc: PWY-6558 Heparan sulfate biosynthesis (late stages) 2 APLA007558-PA;APLA003246-PA Reactome: R-HSA-8874081 MET activates PTK2 signaling 6 APLA003026-PA;APLA003731-PA;APLA004085-PA;APLA004087-PA;APLA003024-PA;APLA011073-PA KEGG: 00640+1.1.1.27 Propanoate metabolism 2 APLA000736-PA;APLA000737-PA KEGG: 00901+2.7.1.222 Indole alkaloid biosynthesis 15 APLA007689-PA;APLA000034-PA;APLA004376-PA;APLA005504-PA;APLA011409-PA;APLA000030-PA;APLA008220-PA;APLA000031-PA;APLA000028-PA;APLA006961-PA;APLA006962-PA;APLA013064-PA;APLA010883-PA;APLA001626-PA;APLA001625-PA KEGG: 00260+5.4.2.11 Glycine, serine and threonine metabolism 2 APLA006779-PA;APLA004744-PA MetaCyc: PWY-6683 Assimilatory sulfate reduction III 1 APLA000768-PA KEGG: 00620+1.8.1.4 Pyruvate metabolism 1 APLA003939-PA Reactome: R-HSA-6803529 FGFR2 alternative splicing 14 APLA002937-PA;APLA006899-PA;APLA003046-PA;APLA008112-PA;APLA002938-PA;APLA015000-PA;APLA003842-PA;APLA000743-PA;APLA008108-PA;APLA013703-PA;APLA014037-PA;APLA014999-PA;APLA014520-PA;APLA001551-PA MetaCyc: PWY-7791 UMP biosynthesis III 2 APLA004501-PA;APLA002345-PA MetaCyc: PWY-7838 Globo-series glycosphingolipids biosynthesis 1 APLA012402-PA MetaCyc: PWY-8060 2-deoxy-D-ribose degradation I 1 APLA014461-PA Reactome: R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 1 APLA012421-PA Reactome: R-HSA-8964208 Phenylalanine metabolism 3 APLA005073-PA;APLA006614-PA;APLA004306-PA Reactome: R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 1 APLA007030-PA KEGG: 00640+6.2.1.5 Propanoate metabolism 5 APLA004846-PA;APLA010449-PA;APLA014289-PA;APLA002458-PA;APLA001878-PA MetaCyc: PWY-7888 Trna-uridine 2-thiolation (cytoplasmic) 1 APLA010314-PA Reactome: R-HSA-163560 Triglyceride catabolism 9 APLA006099-PA;APLA015323-PA;APLA002270-PA;APLA007805-PA;APLA012551-PA;APLA003839-PA;APLA005888-PA;APLA011135-PA;APLA008272-PA Reactome: R-HSA-5689603 UCH proteinases 42 APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA015473-PA;APLA000829-PA;APLA008686-PA;APLA011713-PA;APLA009371-PA;APLA010460-PA;APLA004504-PA;APLA014771-PA;APLA008987-PA;APLA011706-PA;APLA006975-PA;APLA000810-PA;APLA000126-PA;APLA008836-PA;APLA013968-PA;APLA005704-PA;APLA001601-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA014016-PA;APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA013208-PA;APLA006943-PA;APLA010995-PA;APLA006584-PA;APLA002288-PA;APLA010791-PA;APLA002900-PA;APLA010347-PA;APLA005756-PA;APLA012593-PA;APLA005719-PA;APLA003793-PA;APLA007463-PA;APLA003700-PA MetaCyc: PWY-7394 Urate conversion to allantoin II 1 APLA000730-PA Reactome: R-HSA-8948216 Collagen chain trimerization 2 APLA003085-PA;APLA003082-PA MetaCyc: PWY-5890 Menaquinol-10 biosynthesis 1 APLA015235-PA Reactome: R-HSA-174403 Glutathione synthesis and recycling 9 APLA003096-PA;APLA003098-PA;APLA009670-PA;APLA011248-PA;APLA010672-PA;APLA013161-PA;APLA011246-PA;APLA014013-PA;APLA009968-PA KEGG: 00643+3.7.1.2 Styrene degradation 1 APLA012222-PA Reactome: R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 7 APLA009703-PA;APLA004209-PA;APLA000510-PA;APLA014259-PA;APLA011389-PA;APLA013191-PA;APLA008150-PA MetaCyc: PWY-5749 Itaconate degradation 1 APLA010449-PA KEGG: 00260+3.1.3.3 Glycine, serine and threonine metabolism 1 APLA014671-PA KEGG: 00270+2.5.1.6 Cysteine and methionine metabolism 1 APLA008908-PA Reactome: R-HSA-69202 Cyclin E associated events during G1/S transition 4 APLA001457-PA;APLA011446-PA;APLA005348-PA;APLA001596-PA Reactome: R-HSA-1963642 PI3K events in ERBB2 signaling 1 APLA006305-PA KEGG: 04070+3.1.3.78 Phosphatidylinositol signaling system 1 APLA008422-PA Reactome: R-HSA-350054 Notch-HLH transcription pathway 11 APLA008278-PA;APLA005176-PA;APLA008956-PA;APLA011927-PA;APLA005175-PA;APLA005949-PA;APLA000606-PA;APLA002675-PA;APLA001380-PA;APLA001407-PA;APLA013383-PA KEGG: 00020+6.2.1.5 Citrate cycle (TCA cycle) 5 APLA002458-PA;APLA014289-PA;APLA010449-PA;APLA004846-PA;APLA001878-PA KEGG: 00230+2.7.1.20 Purine metabolism 3 APLA001538-PA;APLA001446-PA;APLA009855-PA KEGG: 00950+2.6.1.1 Isoquinoline alkaloid biosynthesis 2 APLA012145-PA;APLA012983-PA KEGG: 00561+2.3.1.20 Glycerolipid metabolism 2 APLA000150-PA;APLA000151-PA KEGG: 00062+4.2.1.17+1.1.1.35 Fatty acid elongation 4 APLA006174-PA;APLA006178-PA;APLA014896-PA;APLA000468-PA Reactome: R-HSA-5632987 Defective Mismatch Repair Associated With PMS2 1 APLA005929-PA KEGG: 00332+2.7.2.11+1.2.1.41 Carbapenem biosynthesis 1 APLA007435-PA KEGG: 00630+3.5.1.9 Glyoxylate and dicarboxylate metabolism 1 APLA005085-PA KEGG: 00750+2.7.1.35 Vitamin B6 metabolism 2 APLA007551-PA;APLA012135-PA Reactome: R-HSA-389661 Glyoxylate metabolism and glycine degradation 22 APLA005733-PA;APLA009541-PA;APLA007913-PA;APLA011356-PA;APLA003749-PA;APLA004383-PA;APLA003939-PA;APLA004881-PA;APLA006355-PA;APLA003091-PA;APLA001487-PA;APLA003152-PA;APLA014770-PA;APLA011728-PA;APLA005998-PA;APLA011349-PA;APLA008950-PA;APLA009540-PA;APLA011729-PA;APLA003168-PA;APLA015266-PA;APLA012074-PA KEGG: 00600+3.1.4.12 Sphingolipid metabolism 3 APLA012329-PA;APLA012328-PA;APLA002142-PA Reactome: R-HSA-9664565 Signaling by ERBB2 KD Mutants 2 APLA009848-PA;APLA006305-PA MetaCyc: PWY-7277 Sphingolipid biosynthesis (mammals) 3 APLA012328-PA;APLA012329-PA;APLA002142-PA Reactome: R-HSA-110312 Translesion synthesis by REV1 13 APLA002288-PA;APLA014545-PA;APLA010387-PA;APLA000884-PA;APLA005000-PA;APLA014841-PA;APLA005141-PA;APLA002832-PA;APLA014272-PA;APLA003193-PA;APLA001459-PA;APLA002790-PA;APLA001691-PA Reactome: R-HSA-2214320 Anchoring fibril formation 3 APLA003082-PA;APLA004965-PA;APLA003085-PA Reactome: R-HSA-3214815 HDACs deacetylate histones 10 APLA014515-PA;APLA012596-PA;APLA005176-PA;APLA005175-PA;APLA011270-PA;APLA000606-PA;APLA011133-PA;APLA005702-PA;APLA010094-PA;APLA013383-PA KEGG: 00230+3.1.4.53 Purine metabolism 2 APLA003228-PA;APLA003229-PA Reactome: R-HSA-8866427 VLDLR internalisation and degradation 2 APLA008115-PA;APLA001793-PA MetaCyc: PWY-6308 L-cysteine biosynthesis II (tRNA-dependent) 1 APLA011624-PA MetaCyc: PWY-6385 Peptidoglycan biosynthesis III (mycobacteria) 1 APLA009515-PA KEGG: 00280+1.1.1.31 Valine, leucine and isoleucine degradation 1 APLA014528-PA KEGG: 00500+3.2.1.26 Starch and sucrose metabolism 2 APLA006128-PA;APLA000024-PA KEGG: 00010+3.1.3.11 Glycolysis / Gluconeogenesis 1 APLA009512-PA KEGG: 00710+5.1.3.1 Carbon fixation in photosynthetic organisms 1 APLA015453-PA Reactome: R-HSA-166208 mTORC1-mediated signalling 10 APLA009658-PA;APLA008732-PA;APLA002692-PA;APLA003509-PA;APLA014094-PA;APLA005545-PA;APLA010301-PA;APLA005454-PA;APLA009758-PA;APLA004140-PA Reactome: R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 35 APLA008790-PA;APLA010460-PA;APLA004504-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA009873-PA;APLA008686-PA;APLA011713-PA;APLA013968-PA;APLA005704-PA;APLA001601-PA;APLA008987-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA000126-PA;APLA008836-PA;APLA014016-PA;APLA001313-PA;APLA014272-PA;APLA002873-PA;APLA002428-PA;APLA012977-PA;APLA015028-PA;APLA013223-PA;APLA010347-PA;APLA005756-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA006943-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA KEGG: 00660+6.2.1.5 C5-Branched dibasic acid metabolism 5 APLA001878-PA;APLA014289-PA;APLA010449-PA;APLA004846-PA;APLA002458-PA KEGG: 00531+3.1.6.14 Glycosaminoglycan degradation 1 APLA005913-PA Reactome: R-HSA-6806664 Metabolism of vitamin K 3 APLA005834-PA;APLA014982-PA;APLA000483-PA Reactome: R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 10 APLA003037-PA;APLA007416-PA;APLA007417-PA;APLA003039-PA;APLA005245-PA;APLA014278-PA;APLA010182-PA;APLA013400-PA;APLA009113-PA;APLA003348-PA KEGG: 00072+2.3.3.10 Synthesis and degradation of ketone bodies 1 APLA007166-PA Reactome: R-HSA-212300 PRC2 methylates histones and DNA 4 APLA004194-PA;APLA000162-PA;APLA005906-PA;APLA007888-PA Reactome: R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 1 APLA009848-PA MetaCyc: PWY-6502 8-oxo-(d)GTP detoxification I 1 APLA000428-PA KEGG: 00520+3.5.99.6 Amino sugar and nucleotide sugar metabolism 2 APLA010998-PA;APLA000788-PA KEGG: 00760+2.4.2.1 Nicotinate and nicotinamide metabolism 2 APLA013738-PA;APLA000262-PA Reactome: R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 1 APLA009848-PA Reactome: R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 84 APLA013392-PA;APLA010839-PA;APLA008614-PA;APLA005404-PA;APLA009213-PA;APLA010013-PA;APLA008588-PA;APLA004075-PA;APLA000488-PA;APLA005999-PA;APLA009753-PA;APLA012185-PA;APLA004544-PA;APLA003770-PA;APLA000682-PA;APLA010605-PA;APLA005265-PA;APLA002086-PA;APLA000050-PA;APLA003102-PA;APLA006079-PA;APLA003269-PA;APLA010999-PA;APLA013231-PA;APLA009495-PA;APLA003217-PA;APLA015388-PA;APLA011066-PA;APLA001686-PA;APLA012151-PA;APLA007319-PA;APLA005384-PA;APLA000956-PA;APLA003064-PA;APLA012609-PA;APLA009234-PA;APLA001987-PA;APLA014107-PA;APLA007956-PA;APLA003286-PA;APLA005196-PA;APLA012911-PA;APLA006227-PA;APLA001622-PA;APLA015197-PA;APLA009149-PA;APLA008766-PA;APLA006379-PA;APLA007492-PA;APLA000210-PA;APLA000130-PA;APLA002625-PA;APLA007375-PA;APLA005454-PA;APLA003509-PA;APLA005476-PA;APLA002288-PA;APLA011333-PA;APLA006586-PA;APLA002114-PA;APLA014444-PA;APLA003093-PA;APLA012986-PA;APLA014343-PA;APLA014272-PA;APLA014985-PA;APLA002294-PA;APLA010040-PA;APLA008225-PA;APLA012226-PA;APLA000605-PA;APLA004503-PA;APLA006618-PA;APLA005706-PA;APLA014384-PA;APLA003014-PA;APLA005697-PA;APLA001093-PA;APLA014029-PA;APLA012910-PA;APLA013210-PA;APLA010469-PA;APLA014046-PA;APLA013308-PA KEGG: 00240+3.6.1.9 Pyrimidine metabolism 2 APLA009005-PA;APLA009849-PA MetaCyc: PWY-5981 CDP-diacylglycerol biosynthesis III 8 APLA012686-PA;APLA008024-PA;APLA003095-PA;APLA008027-PA;APLA000543-PA;APLA004147-PA;APLA002731-PA;APLA014471-PA Reactome: R-HSA-8964026 Chylomicron clearance 3 APLA003678-PA;APLA002555-PA;APLA003544-PA Reactome: R-HSA-4341670 Defective NEU1 causes sialidosis 1 APLA003237-PA Reactome: R-HSA-4420097 VEGFA-VEGFR2 Pathway 9 APLA005249-PA;APLA004850-PA;APLA006952-PA;APLA010464-PA;APLA005856-PA;APLA003690-PA;APLA005606-PA;APLA008080-PA;APLA002486-PA KEGG: 00620+1.1.1.27 Pyruvate metabolism 2 APLA000737-PA;APLA000736-PA Reactome: R-HSA-422356 Regulation of insulin secretion 1 APLA003653-PA Reactome: R-HSA-8851680 Butyrophilin (BTN) family interactions 1 APLA002333-PA KEGG: 00480+2.5.1.18+1.8.5.1 Glutathione metabolism 1 APLA014577-PA KEGG: 00983+3.5.4.5 Drug metabolism - other enzymes 1 APLA000366-PA Reactome: R-HSA-264876 Insulin processing 9 APLA005819-PA;APLA012196-PA;APLA001935-PA;APLA004877-PA;APLA012012-PA;APLA007920-PA;APLA005586-PA;APLA007146-PA;APLA007925-PA KEGG: 00630+6.2.1.1 Glyoxylate and dicarboxylate metabolism 2 APLA008135-PA;APLA006387-PA KEGG: 00920+2.7.1.25 Sulfur metabolism 1 APLA000768-PA KEGG: 00250+6.3.5.4 Alanine, aspartate and glutamate metabolism 2 APLA012906-PA;APLA012902-PA Reactome: R-HSA-4755609 Defective DHDDS causes retinitis pigmentosa 59 2 APLA000371-PA;APLA014320-PA Reactome: R-HSA-5655862 Translesion synthesis by POLK 13 APLA002288-PA;APLA005141-PA;APLA001459-PA;APLA014272-PA;APLA003193-PA;APLA002832-PA;APLA001691-PA;APLA002790-PA;APLA014545-PA;APLA010387-PA;APLA000884-PA;APLA005000-PA;APLA014841-PA Reactome: R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 6 APLA011087-PA;APLA011894-PA;APLA011085-PA;APLA013952-PA;APLA011893-PA;APLA011086-PA Reactome: R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 1 APLA004586-PA MetaCyc: PWY-7798 Protein S-nitrosylation and denitrosylation 1 APLA001970-PA Reactome: R-HSA-201681 TCF dependent signaling in response to WNT 5 APLA013928-PA;APLA005611-PA;APLA001168-PA;APLA014272-PA;APLA002288-PA KEGG: 00620+4.1.1.32 Pyruvate metabolism 1 APLA013213-PA KEGG: 00230+3.6.1.15 Purine metabolism 1 APLA001305-PA Reactome: R-HSA-2470946 Cohesin Loading onto Chromatin 4 APLA013964-PA;APLA015065-PA;APLA008230-PA;APLA004645-PA MetaCyc: PWY-4302 Aerobic respiration III (alternative oxidase pathway) 5 APLA006254-PA;APLA015489-PA;APLA003262-PA;APLA000357-PA;APLA013330-PA Reactome: R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 4 APLA000577-PA;APLA001848-PA;APLA010400-PA;APLA003133-PA MetaCyc: PWY-1361 Benzoyl-coa degradation I (aerobic) 4 APLA000468-PA;APLA006174-PA;APLA014896-PA;APLA006178-PA MetaCyc: PWY-7727 Docosahexaenoate biosynthesis IV (4-desaturase, mammals) 2 APLA008114-PA;APLA005258-PA MetaCyc: PWY-6857 Retinol biosynthesis 2 APLA001794-PA;APLA003983-PA Reactome: R-HSA-8868766 rRNA processing in the mitochondrion 3 APLA001197-PA;APLA005825-PA;APLA001199-PA MetaCyc: PWY-7377 Cob(ii)yrinate a,c-diamide biosynthesis I (early cobalt insertion) 1 APLA003859-PA Reactome: R-HSA-182218 Nef Mediated CD8 Down-regulation 4 APLA003280-PA;APLA001793-PA;APLA008115-PA;APLA000368-PA MetaCyc: PWY-3821 D-galactose detoxification 2 APLA001443-PA;APLA014848-PA Reactome: R-HSA-6782135 Dual incision in TC-NER 38 APLA015384-PA;APLA000879-PA;APLA014921-PA;APLA001194-PA;APLA005000-PA;APLA014037-PA;APLA010986-PA;APLA002832-PA;APLA008283-PA;APLA003279-PA;APLA003842-PA;APLA012424-PA;APLA002288-PA;APLA008788-PA;APLA014197-PA;APLA003046-PA;APLA010387-PA;APLA009703-PA;APLA000884-PA;APLA001596-PA;APLA014520-PA;APLA006016-PA;APLA001691-PA;APLA014272-PA;APLA001551-PA;APLA013813-PA;APLA001459-PA;APLA013703-PA;APLA000743-PA;APLA014545-PA;APLA003196-PA;APLA014841-PA;APLA006346-PA;APLA005141-PA;APLA002790-PA;APLA003193-PA;APLA013151-PA;APLA001624-PA KEGG: 00970+6.1.1.22 Aminoacyl-tRNA biosynthesis 2 APLA010862-PA;APLA004213-PA Reactome: R-HSA-68616 Assembly of the ORC complex at the origin of replication 6 APLA001663-PA;APLA002390-PA;APLA014433-PA;APLA013214-PA;APLA007715-PA;APLA008067-PA KEGG: 00071+4.2.1.17+1.1.1.35 Fatty acid degradation 4 APLA014896-PA;APLA006178-PA;APLA006174-PA;APLA000468-PA MetaCyc: PWY-6891 Thiazole biosynthesis II (aerobic bacteria) 1 APLA003487-PA MetaCyc: PWY-6368 3-phosphoinositide degradation 3 APLA007407-PA;APLA008422-PA;APLA001445-PA MetaCyc: PWY-6898 Thiamine salvage III 1 APLA005503-PA MetaCyc: PWY-6620 Guanine and guanosine salvage 2 APLA000262-PA;APLA013738-PA Reactome: R-HSA-432722 Golgi Associated Vesicle Biogenesis 2 APLA008679-PA;APLA009419-PA MetaCyc: PWY-3561 Choline biosynthesis III 1 APLA011460-PA KEGG: 00030+4.1.2.4 Pentose phosphate pathway 1 APLA014461-PA MetaCyc: PWY-6802 Salidroside biosynthesis 1 APLA001970-PA Reactome: R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 2 APLA009882-PA;APLA014258-PA Reactome: R-HSA-3000484 Scavenging by Class F Receptors 3 APLA003544-PA;APLA003678-PA;APLA002555-PA MetaCyc: PWY-7193 Pyrimidine ribonucleosides salvage I 3 APLA008439-PA;APLA002052-PA;APLA000366-PA Reactome: R-HSA-3371453 Regulation of HSF1-mediated heat shock response 42 APLA003482-PA;APLA001541-PA;APLA005056-PA;APLA002304-PA;APLA011125-PA;APLA013473-PA;APLA001290-PA;APLA006060-PA;APLA001965-PA;APLA000490-PA;APLA006869-PA;APLA013005-PA;APLA000238-PA;APLA011986-PA;APLA000426-PA;APLA003193-PA;APLA002878-PA;APLA005141-PA;APLA013003-PA;APLA000427-PA;APLA005470-PA;APLA014545-PA;APLA010643-PA;APLA009744-PA;APLA002444-PA;APLA002832-PA;APLA015091-PA;APLA002235-PA;APLA011447-PA;APLA004137-PA;APLA008175-PA;APLA015058-PA;APLA000239-PA;APLA002140-PA;APLA005336-PA;APLA005231-PA;APLA005565-PA;APLA002065-PA;APLA011523-PA;APLA002308-PA;APLA005469-PA;APLA009708-PA Reactome: R-HSA-9656255 Defective OGG1 Substrate Binding 1 APLA010076-PA MetaCyc: PWY-6842 Glutathione-mediated detoxification II 4 APLA004294-PA;APLA014577-PA;APLA004293-PA;APLA004285-PA KEGG: 00480+6.3.2.2 Glutathione metabolism 4 APLA009670-PA;APLA003098-PA;APLA013161-PA;APLA003096-PA KEGG: 00240+3.5.4.5 Pyrimidine metabolism 1 APLA000366-PA Reactome: R-HSA-9033241 Peroxisomal protein import 31 APLA004183-PA;APLA008349-PA;APLA008348-PA;APLA009540-PA;APLA011729-PA;APLA009588-PA;APLA000667-PA;APLA004174-PA;APLA003946-PA;APLA004171-PA;APLA004141-PA;APLA006339-PA;APLA003250-PA;APLA006839-PA;APLA008347-PA;APLA013190-PA;APLA014272-PA;APLA011728-PA;APLA006341-PA;APLA002288-PA;APLA004582-PA;APLA007576-PA;APLA015327-PA;APLA004175-PA;APLA004172-PA;APLA009541-PA;APLA004182-PA;APLA004173-PA;APLA004588-PA;APLA014838-PA;APLA004184-PA Reactome: R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 17 APLA000113-PA;APLA009711-PA;APLA005484-PA;APLA007139-PA;APLA012594-PA;APLA005703-PA;APLA001551-PA;APLA002219-PA;APLA004561-PA;APLA013703-PA;APLA012008-PA;APLA014037-PA;APLA005113-PA;APLA000743-PA;APLA001389-PA;APLA008215-PA;APLA003046-PA MetaCyc: PWY-7383 Anaerobic energy metabolism (invertebrates, cytosol) 8 APLA014952-PA;APLA005378-PA;APLA013213-PA;APLA012983-PA;APLA015456-PA;APLA012145-PA;APLA000684-PA;APLA015268-PA Reactome: R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 2 APLA002288-PA;APLA014272-PA KEGG: 04070+2.7.1.158 Phosphatidylinositol signaling system 1 APLA014683-PA Reactome: R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 2 APLA008489-PA;APLA008490-PA Reactome: R-HSA-8963684 Tyrosine catabolism 4 APLA015390-PA;APLA008824-PA;APLA012222-PA;APLA013125-PA MetaCyc: PWY-6689 Trna splicing I 2 APLA000315-PA;APLA000369-PA Reactome: R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 11 APLA005540-PA;APLA000049-PA;APLA009217-PA;APLA008961-PA;APLA009349-PA;APLA007959-PA;APLA010851-PA;APLA005863-PA;APLA008823-PA;APLA014716-PA;APLA014519-PA Reactome: R-HSA-1268020 Mitochondrial protein import 30 APLA000598-PA;APLA003393-PA;APLA010695-PA;APLA012657-PA;APLA008464-PA;APLA010376-PA;APLA012188-PA;APLA008779-PA;APLA009120-PA;APLA014065-PA;APLA005010-PA;APLA007977-PA;APLA006636-PA;APLA014516-PA;APLA007986-PA;APLA013473-PA;APLA002277-PA;APLA010491-PA;APLA010276-PA;APLA009176-PA;APLA009841-PA;APLA012125-PA;APLA007580-PA;APLA001650-PA;APLA006919-PA;APLA003691-PA;APLA001849-PA;APLA010815-PA;APLA008781-PA;APLA006903-PA Reactome: R-HSA-164939 Nef mediated downregulation of CD28 cell surface expression 1 APLA001793-PA Reactome: R-HSA-3928663 EPHA-mediated growth cone collapse 1 APLA008080-PA KEGG: 00650+2.3.3.10 Butanoate metabolism 1 APLA007166-PA Reactome: R-HSA-5674135 MAP2K and MAPK activation 2 APLA002140-PA;APLA001451-PA KEGG: 00380+1.14.13.9 Tryptophan metabolism 1 APLA001933-PA Reactome: R-HSA-5099900 WNT5A-dependent internalization of FZD4 3 APLA008115-PA;APLA001793-PA;APLA010150-PA KEGG: 00520+3.2.1.14 Amino sugar and nucleotide sugar metabolism 8 APLA015396-PA;APLA001425-PA;APLA003546-PA;APLA005525-PA;APLA003813-PA;APLA001426-PA;APLA003440-PA;APLA007660-PA MetaCyc: PWY-5857 Ubiquinol-10 biosynthesis (prokaryotic) 1 APLA002418-PA Reactome: R-HSA-6790901 rRNA modification in the nucleus and cytosol 38 APLA011278-PA;APLA003769-PA;APLA008275-PA;APLA004341-PA;APLA014588-PA;APLA007891-PA;APLA010330-PA;APLA014002-PA;APLA012302-PA;APLA013308-PA;APLA011531-PA;APLA006697-PA;APLA007956-PA;APLA009234-PA;APLA002533-PA;APLA011488-PA;APLA001036-PA;APLA012726-PA;APLA011026-PA;APLA013884-PA;APLA014004-PA;APLA010884-PA;APLA004544-PA;APLA000258-PA;APLA009184-PA;APLA001035-PA;APLA003509-PA;APLA005454-PA;APLA001304-PA;APLA006556-PA;APLA014137-PA;APLA010091-PA;APLA002364-PA;APLA007878-PA;APLA006509-PA;APLA004032-PA;APLA006510-PA;APLA002256-PA Reactome: R-HSA-1483213 Synthesis of PE 2 APLA001595-PA;APLA009513-PA MetaCyc: PWY-5642 2,4-dinitrotoluene degradation 1 APLA000040-PA Reactome: R-HSA-376172 DSCAM interactions 1 APLA005606-PA MetaCyc: PWY-7185 UTP and CTP dephosphorylation I 4 APLA012076-PA;APLA010349-PA;APLA001305-PA;APLA002282-PA Reactome: R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 12 APLA015064-PA;APLA001551-PA;APLA014520-PA;APLA014037-PA;APLA013703-PA;APLA003842-PA;APLA000743-PA;APLA001132-PA;APLA011837-PA;APLA001514-PA;APLA003046-PA;APLA000162-PA Reactome: R-HSA-3214841 PKMTs methylate histone lysines 14 APLA011917-PA;APLA008756-PA;APLA006438-PA;APLA007967-PA;APLA009436-PA;APLA000603-PA;APLA003597-PA;APLA009473-PA;APLA014539-PA;APLA003315-PA;APLA001309-PA;APLA014062-PA;APLA000162-PA;APLA012795-PA Reactome: R-HSA-112043 PLC beta mediated events 6 APLA012536-PA;APLA006557-PA;APLA003536-PA;APLA013772-PA;APLA003653-PA;APLA006554-PA MetaCyc: PWY-7124 Ethylene biosynthesis V (engineered) 5 APLA007919-PA;APLA010497-PA;APLA010500-PA;APLA010499-PA;APLA001137-PA Reactome: R-HSA-68877 Mitotic Prometaphase 41 APLA014998-PA;APLA001683-PA;APLA002909-PA;APLA011986-PA;APLA000426-PA;APLA002859-PA;APLA001633-PA;APLA013359-PA;APLA014679-PA;APLA001351-PA;APLA000427-PA;APLA002856-PA;APLA005242-PA;APLA007552-PA;APLA002551-PA;APLA010596-PA;APLA015031-PA;APLA014307-PA;APLA001833-PA;APLA002135-PA;APLA009660-PA;APLA010198-PA;APLA015416-PA;APLA004383-PA;APLA010197-PA;APLA007858-PA;APLA012338-PA;APLA010196-PA;APLA014048-PA;APLA008446-PA;APLA003480-PA;APLA014850-PA;APLA014772-PA;APLA013547-PA;APLA013357-PA;APLA010643-PA;APLA002883-PA;APLA004639-PA;APLA001953-PA;APLA009417-PA;APLA015058-PA MetaCyc: PWY-7857 Adlupulone and adhumulone biosynthesis 2 APLA008135-PA;APLA006387-PA Reactome: R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 1 APLA003653-PA MetaCyc: PWY-5194 Siroheme biosynthesis 1 APLA003859-PA MetaCyc: PWY-3162 L-tryptophan degradation V (side chain pathway) 1 APLA001970-PA MetaCyc: PWY-5366 Palmitoleate biosynthesis II (plants and bacteria) 3 APLA002072-PA;APLA002545-PA;APLA007857-PA KEGG: 00040+2.7.7.9 Pentose and glucuronate interconversions 1 APLA003021-PA Reactome: R-HSA-9636467 Blockage of phagosome acidification 2 APLA003280-PA;APLA000368-PA KEGG: 00564+2.7.1.107 Glycerophospholipid metabolism 5 APLA006190-PA;APLA013224-PA;APLA012308-PA;APLA011921-PA;APLA011740-PA KEGG: 00860+2.5.1.141 Porphyrin and chlorophyll metabolism 1 APLA003714-PA KEGG: 00760+3.6.1.9 Nicotinate and nicotinamide metabolism 2 APLA009005-PA;APLA009849-PA Reactome: R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 2 APLA014272-PA;APLA002288-PA KEGG: 00052+3.2.1.23 Galactose metabolism 5 APLA004972-PA;APLA001673-PA;APLA001817-PA;APLA004969-PA;APLA005795-PA Reactome: R-HSA-110320 Translesion Synthesis by POLH 20 APLA002832-PA;APLA001459-PA;APLA000402-PA;APLA000400-PA;APLA002022-PA;APLA005000-PA;APLA001872-PA;APLA002288-PA;APLA007052-PA;APLA003193-PA;APLA014272-PA;APLA002790-PA;APLA001691-PA;APLA005141-PA;APLA008790-PA;APLA000884-PA;APLA014841-PA;APLA010387-PA;APLA014545-PA;APLA004524-PA KEGG: 00450+6.1.1.10 Selenocompound metabolism 2 APLA001592-PA;APLA003938-PA Reactome: R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 16 APLA004137-PA;APLA006060-PA;APLA015058-PA;APLA001290-PA;APLA011447-PA;APLA010643-PA;APLA003482-PA;APLA002444-PA;APLA000427-PA;APLA009708-PA;APLA002878-PA;APLA005565-PA;APLA011986-PA;APLA000426-PA;APLA005231-PA;APLA005336-PA KEGG: 00230+3.5.4.10+2.1.2.3 Purine metabolism 1 APLA008244-PA KEGG: 00010+1.2.1.12 Glycolysis / Gluconeogenesis 3 APLA007488-PA;APLA007679-PA;APLA000476-PA MetaCyc: PWY-6453 Stigma estolide biosynthesis 8 APLA014471-PA;APLA004147-PA;APLA000543-PA;APLA008027-PA;APLA009816-PA;APLA002667-PA;APLA001595-PA;APLA012686-PA Reactome: R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 62 APLA007021-PA;APLA002551-PA;APLA005677-PA;APLA010596-PA;APLA005501-PA;APLA004844-PA;APLA013359-PA;APLA004714-PA;APLA008532-PA;APLA012304-PA;APLA014998-PA;APLA010110-PA;APLA010940-PA;APLA012207-PA;APLA014714-PA;APLA015416-PA;APLA004383-PA;APLA000849-PA;APLA011337-PA;APLA007638-PA;APLA010197-PA;APLA010198-PA;APLA014593-PA;APLA013662-PA;APLA015031-PA;APLA014038-PA;APLA012813-PA;APLA014307-PA;APLA009947-PA;APLA005427-PA;APLA013357-PA;APLA000850-PA;APLA007067-PA;APLA000959-PA;APLA000198-PA;APLA010011-PA;APLA014850-PA;APLA007063-PA;APLA005946-PA;APLA007858-PA;APLA012338-PA;APLA008446-PA;APLA003650-PA;APLA014048-PA;APLA010196-PA;APLA005944-PA;APLA000171-PA;APLA002181-PA;APLA012208-PA;APLA010422-PA;APLA011335-PA;APLA009417-PA;APLA008442-PA;APLA003990-PA;APLA010448-PA;APLA004732-PA;APLA014986-PA;APLA001953-PA;APLA000955-PA;APLA009093-PA;APLA002355-PA;APLA000140-PA MetaCyc: PWY-6535 4-aminobutanoate degradation I 1 APLA003896-PA KEGG: 00960+2.6.1.5 Tropane, piperidine and pyridine alkaloid biosynthesis 1 APLA013125-PA Reactome: R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 4 APLA004700-PA;APLA008956-PA;APLA014272-PA;APLA002288-PA Reactome: R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 2 APLA014272-PA;APLA002288-PA KEGG: 00730+2.7.4.3 Thiamine metabolism 6 APLA008966-PA;APLA014549-PA;APLA002792-PA;APLA006751-PA;APLA015335-PA;APLA013251-PA Reactome: R-HSA-111458 Formation of apoptosome 4 APLA013736-PA;APLA009642-PA;APLA009882-PA;APLA009072-PA MetaCyc: PWY-7165 L-ascorbate biosynthesis VI (engineered pathway) 1 APLA005270-PA Reactome: R-HSA-211981 Xenobiotics 3 APLA007545-PA;APLA007345-PA;APLA002850-PA KEGG: 00460+3.5.1.1 Cyanoamino acid metabolism 3 APLA005073-PA;APLA004306-PA;APLA004354-PA KEGG: 00020+1.8.1.4 Citrate cycle (TCA cycle) 1 APLA003939-PA Reactome: R-HSA-5218920 VEGFR2 mediated vascular permeability 7 APLA002343-PA;APLA013745-PA;APLA011144-PA;APLA005249-PA;APLA014094-PA;APLA005545-PA;APLA010399-PA MetaCyc: PWY-6840 Homoglutathione biosynthesis 4 APLA009670-PA;APLA003098-PA;APLA003096-PA;APLA013161-PA Reactome: R-HSA-1169408 ISG15 antiviral mechanism 22 APLA002444-PA;APLA002288-PA;APLA010643-PA;APLA003482-PA;APLA015058-PA;APLA006060-PA;APLA004137-PA;APLA001290-PA;APLA002485-PA;APLA011447-PA;APLA005231-PA;APLA005336-PA;APLA000426-PA;APLA011986-PA;APLA004186-PA;APLA009708-PA;APLA000427-PA;APLA002878-PA;APLA004371-PA;APLA005565-PA;APLA014272-PA;APLA000777-PA Reactome: R-HSA-418885 DCC mediated attractive signaling 1 APLA004850-PA MetaCyc: PWY-5849 Menaquinol-6 biosynthesis 1 APLA015235-PA KEGG: 00480+2.3.2.2+3.4.19.13 Glutathione metabolism 3 APLA004294-PA;APLA004285-PA;APLA004293-PA KEGG: 00053+3.1.1.17 Ascorbate and aldarate metabolism 1 APLA005270-PA KEGG: 00020+6.2.1.4 Citrate cycle (TCA cycle) 1 APLA010449-PA KEGG: 00680+2.1.2.1 Methane metabolism 1 APLA000499-PA MetaCyc: PWY-5905 Hypusine biosynthesis 1 APLA009762-PA Reactome: R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 2 APLA008489-PA;APLA008490-PA Reactome: R-HSA-69091 Polymerase switching 13 APLA013151-PA;APLA006690-PA;APLA008659-PA;APLA001459-PA;APLA001691-PA;APLA014513-PA;APLA002790-PA;APLA007371-PA;APLA010387-PA;APLA000884-PA;APLA008612-PA;APLA014841-PA;APLA005000-PA KEGG: 00730+3.1.3.1 Thiamine metabolism 11 APLA005796-PA;APLA007909-PA;APLA008562-PA;APLA007910-PA;APLA007908-PA;APLA004522-PA;APLA004280-PA;APLA004282-PA;APLA007911-PA;APLA013467-PA;APLA008563-PA Reactome: R-HSA-379716 Cytosolic tRNA aminoacylation 17 APLA005781-PA;APLA009586-PA;APLA008833-PA;APLA013122-PA;APLA007550-PA;APLA000131-PA;APLA002864-PA;APLA001944-PA;APLA012591-PA;APLA008083-PA;APLA007933-PA;APLA010075-PA;APLA002172-PA;APLA002820-PA;APLA008703-PA;APLA008681-PA;APLA001592-PA Reactome: R-HSA-5654693 FRS-mediated FGFR1 signaling 1 APLA005551-PA Reactome: R-HSA-1663150 The activation of arylsulfatases 1 APLA014467-PA KEGG: 00330+1.2.1.41 Arginine and proline metabolism 1 APLA007436-PA Reactome: R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 1 APLA014258-PA Reactome: R-HSA-73776 RNA Polymerase II Promoter Escape 28 APLA008108-PA;APLA014520-PA;APLA001596-PA;APLA009703-PA;APLA014999-PA;APLA006899-PA;APLA001478-PA;APLA001624-PA;APLA008112-PA;APLA000670-PA;APLA014646-PA;APLA012150-PA;APLA007145-PA;APLA011482-PA;APLA013703-PA;APLA014037-PA;APLA010986-PA;APLA012883-PA;APLA001551-PA;APLA000879-PA;APLA003046-PA;APLA005246-PA;APLA000743-PA;APLA008290-PA;APLA015000-PA;APLA005145-PA;APLA003842-PA;APLA003279-PA Reactome: R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 3 APLA007030-PA;APLA002140-PA;APLA001451-PA Reactome: R-HSA-5633231 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) 1 APLA009515-PA Reactome: R-HSA-4717374 Defective DPM1 causes DPM1-CDG (CDG-1e) 2 APLA013212-PA;APLA006452-PA Reactome: R-HSA-9613829 Chaperone Mediated Autophagy 4 APLA007447-PA;APLA011952-PA;APLA002288-PA;APLA014272-PA Reactome: R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 3 APLA004368-PA;APLA008185-PA;APLA010076-PA Reactome: R-HSA-196780 Biotin transport and metabolism 11 APLA006201-PA;APLA010822-PA;APLA005811-PA;APLA013496-PA;APLA006200-PA;APLA013385-PA;APLA013219-PA;APLA010823-PA;APLA007201-PA;APLA002544-PA;APLA006203-PA Reactome: R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 10 APLA010655-PA;APLA003502-PA;APLA008849-PA;APLA008846-PA;APLA012189-PA;APLA012163-PA;APLA010656-PA;APLA010654-PA;APLA010653-PA;APLA008842-PA Reactome: R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 6 APLA013702-PA;APLA014130-PA;APLA012596-PA;APLA013701-PA;APLA009856-PA;APLA003047-PA MetaCyc: PWY-5172 Acetyl-coa biosynthesis III (from citrate) 1 APLA001878-PA MetaCyc: PWY-5538 Pyruvate fermentation to acetate VI 5 APLA014289-PA;APLA010449-PA;APLA004846-PA;APLA002458-PA;APLA001878-PA KEGG: 00620+1.1.1.37 Pyruvate metabolism 3 APLA005378-PA;APLA000684-PA;APLA015456-PA Reactome: R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 42 APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA007872-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA006943-PA;APLA014003-PA;APLA014272-PA;APLA002428-PA;APLA002873-PA;APLA001313-PA;APLA003055-PA;APLA014016-PA;APLA000940-PA;APLA005264-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA005017-PA;APLA001601-PA;APLA013968-PA;APLA005704-PA;APLA000126-PA;APLA008836-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA013902-PA;APLA008987-PA;APLA004504-PA;APLA010460-PA;APLA000806-PA;APLA011713-PA;APLA011005-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA008686-PA Reactome: R-HSA-1483255 PI Metabolism 1 APLA003703-PA Reactome: R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 29 APLA009185-PA;APLA000743-PA;APLA014024-PA;APLA003279-PA;APLA015000-PA;APLA003842-PA;APLA002938-PA;APLA003046-PA;APLA005321-PA;APLA001456-PA;APLA002937-PA;APLA001551-PA;APLA000879-PA;APLA014037-PA;APLA010986-PA;APLA013703-PA;APLA006924-PA;APLA000547-PA;APLA008112-PA;APLA006899-PA;APLA001624-PA;APLA009703-PA;APLA014520-PA;APLA003187-PA;APLA001596-PA;APLA011795-PA;APLA014999-PA;APLA003048-PA;APLA008108-PA Reactome: R-HSA-936837 Ion transport by P-type ATPases 26 APLA004373-PA;APLA005948-PA;APLA004358-PA;APLA013908-PA;APLA011215-PA;APLA012467-PA;APLA004634-PA;APLA001638-PA;APLA003266-PA;APLA005140-PA;APLA000960-PA;APLA007030-PA;APLA000953-PA;APLA015025-PA;APLA005701-PA;APLA011432-PA;APLA002049-PA;APLA013911-PA;APLA012545-PA;APLA005945-PA;APLA006453-PA;APLA008301-PA;APLA013913-PA;APLA003812-PA;APLA012404-PA;APLA003849-PA Reactome: R-HSA-4719377 Defective DPM2 causes DPM2-CDG (CDG-1u) 2 APLA006452-PA;APLA013212-PA Reactome: R-HSA-2424491 DAP12 signaling 1 APLA014442-PA Reactome: R-HSA-2871796 FCERI mediated MAPK activation 4 APLA004432-PA;APLA014442-PA;APLA002140-PA;APLA005249-PA KEGG: 00020+2.3.1.61 Citrate cycle (TCA cycle) 1 APLA005733-PA Reactome: R-HSA-4570571 Defective RFT1 causes RFT1-CDG (CDG-1n) 1 APLA009657-PA KEGG: 00020+1.1.1.37 Citrate cycle (TCA cycle) 3 APLA005378-PA;APLA000684-PA;APLA015456-PA Reactome: R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 1 APLA009848-PA KEGG: 00360+2.6.1.5 Phenylalanine metabolism 1 APLA013125-PA Reactome: R-HSA-4551638 SUMOylation of chromatin organization proteins 20 APLA011447-PA;APLA002216-PA;APLA001290-PA;APLA008078-PA;APLA006417-PA;APLA015058-PA;APLA006060-PA;APLA004137-PA;APLA002444-PA;APLA003482-PA;APLA010643-PA;APLA000162-PA;APLA005565-PA;APLA002878-PA;APLA009708-PA;APLA000427-PA;APLA005231-PA;APLA000426-PA;APLA005336-PA;APLA011986-PA Reactome: R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 19 APLA012660-PA;APLA009590-PA;APLA012406-PA;APLA005954-PA;APLA006644-PA;APLA009662-PA;APLA006643-PA;APLA013848-PA;APLA014344-PA;APLA014958-PA;APLA003353-PA;APLA000365-PA;APLA004319-PA;APLA006049-PA;APLA005996-PA;APLA009824-PA;APLA008808-PA;APLA014443-PA;APLA009424-PA KEGG: 00030+2.7.1.11 Pentose phosphate pathway 2 APLA013705-PA;APLA013706-PA Reactome: R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 19 APLA000427-PA;APLA009708-PA;APLA002878-PA;APLA005565-PA;APLA011986-PA;APLA005231-PA;APLA005336-PA;APLA000426-PA;APLA004137-PA;APLA006060-PA;APLA015058-PA;APLA001290-PA;APLA011447-PA;APLA010643-PA;APLA002938-PA;APLA003482-PA;APLA008641-PA;APLA002937-PA;APLA002444-PA Reactome: R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 10 APLA009193-PA;APLA010601-PA;APLA009503-PA;APLA010443-PA;APLA009499-PA;APLA002288-PA;APLA009504-PA;APLA004700-PA;APLA014679-PA;APLA014272-PA KEGG: 00620+2.7.1.40 Pyruvate metabolism 1 APLA015268-PA KEGG: 00860+4.2.1.75 Porphyrin and chlorophyll metabolism 1 APLA002668-PA Reactome: R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 4 APLA007020-PA;APLA002378-PA;APLA002314-PA;APLA000217-PA MetaCyc: PWY-8106 Queuosine biosynthesis III (queuosine salvage) 2 APLA008300-PA;APLA009733-PA MetaCyc: PWY-7291 Oleate beta-oxidation (isomerase-dependent, yeast) 2 APLA013190-PA;APLA003250-PA KEGG: 00562+2.7.8.11 Inositol phosphate metabolism 1 APLA010033-PA KEGG: 00240+2.4.2.3 Pyrimidine metabolism 1 APLA001272-PA Reactome: R-HSA-4615885 SUMOylation of DNA replication proteins 21 APLA009708-PA;APLA000427-PA;APLA014841-PA;APLA013547-PA;APLA005565-PA;APLA001691-PA;APLA004984-PA;APLA002878-PA;APLA005231-PA;APLA005336-PA;APLA000426-PA;APLA011986-PA;APLA001683-PA;APLA015058-PA;APLA006060-PA;APLA004137-PA;APLA011447-PA;APLA001290-PA;APLA002444-PA;APLA003482-PA;APLA010643-PA Reactome: R-HSA-189451 Heme biosynthesis 10 APLA002668-PA;APLA003714-PA;APLA002965-PA;APLA010645-PA;APLA007963-PA;APLA007924-PA;APLA003637-PA;APLA008273-PA;APLA001914-PA;APLA008197-PA Reactome: R-HSA-1834941 STING mediated induction of host immune responses 1 APLA007487-PA Reactome: R-HSA-425986 Sodium/Proton exchangers 2 APLA000252-PA;APLA000271-PA Reactome: R-HSA-5676934 Protein repair 2 APLA006650-PA;APLA002696-PA Reactome: R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 2 APLA003264-PA;APLA009770-PA MetaCyc: PWY-7602 Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes) 14 APLA010067-PA;APLA008114-PA;APLA010063-PA;APLA000863-PA;APLA010062-PA;APLA010064-PA;APLA010068-PA;APLA009871-PA;APLA000862-PA;APLA010065-PA;APLA015433-PA;APLA010066-PA;APLA002710-PA;APLA005258-PA Reactome: R-HSA-8853659 RET signaling 4 APLA010641-PA;APLA010639-PA;APLA012421-PA;APLA010640-PA KEGG: 00510+2.4.1.143 N-Glycan biosynthesis 2 APLA007125-PA;APLA012410-PA Reactome: R-HSA-8849932 Synaptic adhesion-like molecules 4 APLA002988-PA;APLA008750-PA;APLA002826-PA;APLA003259-PA Reactome: R-HSA-111447 Activation of BAD and translocation to mitochondria 2 APLA011959-PA;APLA003528-PA KEGG: 00053+1.1.1.22 Ascorbate and aldarate metabolism 1 APLA005458-PA MetaCyc: PWY-7790 UMP biosynthesis II 2 APLA002345-PA;APLA004501-PA KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41 Biotin metabolism 3 APLA007857-PA;APLA002545-PA;APLA002072-PA Reactome: R-HSA-9639288 Amino acids regulate mTORC1 30 APLA009758-PA;APLA010311-PA;APLA007060-PA;APLA000368-PA;APLA005545-PA;APLA005327-PA;APLA003149-PA;APLA000114-PA;APLA000056-PA;APLA010425-PA;APLA015304-PA;APLA002471-PA;APLA015217-PA;APLA012089-PA;APLA005382-PA;APLA014094-PA;APLA001263-PA;APLA006357-PA;APLA013217-PA;APLA010301-PA;APLA002666-PA;APLA012619-PA;APLA002692-PA;APLA013123-PA;APLA000821-PA;APLA006015-PA;APLA009658-PA;APLA003280-PA;APLA001114-PA;APLA008732-PA MetaCyc: PWY-7356 Thiamine salvage IV (yeast) 1 APLA005503-PA KEGG: 00562+5.3.1.1 Inositol phosphate metabolism 1 APLA006547-PA MetaCyc: PWY-7219 Adenosine ribonucleotides de novo biosynthesis 8 APLA008966-PA;APLA007491-PA;APLA002792-PA;APLA006751-PA;APLA015335-PA;APLA013251-PA;APLA007847-PA;APLA014549-PA KEGG: 00520+5.4.2.8 Amino sugar and nucleotide sugar metabolism 1 APLA009743-PA MetaCyc: PWY-6342 Noradrenaline and adrenaline degradation 1 APLA001970-PA Reactome: R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 30 APLA010434-PA;APLA000215-PA;APLA011721-PA;APLA003070-PA;APLA004211-PA;APLA005325-PA;APLA011572-PA;APLA014924-PA;APLA002757-PA;APLA007861-PA;APLA001607-PA;APLA009210-PA;APLA006388-PA;APLA014128-PA;APLA012470-PA;APLA002231-PA;APLA001606-PA;APLA015026-PA;APLA004548-PA;APLA014769-PA;APLA003953-PA;APLA008949-PA;APLA013640-PA;APLA006597-PA;APLA008596-PA;APLA009953-PA;APLA004549-PA;APLA006012-PA;APLA003190-PA;APLA014324-PA KEGG: 00720+6.4.1.1 Carbon fixation pathways in prokaryotes 1 APLA013385-PA Reactome: R-HSA-1482839 Acyl chain remodelling of PE 4 APLA004469-PA;APLA009079-PA;APLA005748-PA;APLA005749-PA KEGG: 00531+3.2.1.35 Glycosaminoglycan degradation 1 APLA009426-PA MetaCyc: PWY-7661 Protein N-glycosylation (Haloferax volcanii) 1 APLA013212-PA KEGG: 00040+5.1.3.1 Pentose and glucuronate interconversions 1 APLA015453-PA MetaCyc: PWY-561 Superpathway of glyoxylate cycle and fatty acid degradation 9 APLA013330-PA;APLA005378-PA;APLA003262-PA;APLA015456-PA;APLA000357-PA;APLA000684-PA;APLA015489-PA;APLA003089-PA;APLA006254-PA KEGG: 00250+2.6.1.1 Alanine, aspartate and glutamate metabolism 2 APLA012145-PA;APLA012983-PA Reactome: R-HSA-2465910 MASTL Facilitates Mitotic Progression 2 APLA008151-PA;APLA012812-PA Reactome: R-HSA-5683826 Surfactant metabolism 3 APLA006726-PA;APLA006728-PA;APLA015153-PA KEGG: 00534+5.1.3.17 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1 APLA003246-PA Reactome: R-HSA-4085377 SUMOylation of SUMOylation proteins 16 APLA003482-PA;APLA010643-PA;APLA002444-PA;APLA006060-PA;APLA004137-PA;APLA015058-PA;APLA011447-PA;APLA001290-PA;APLA011986-PA;APLA000426-PA;APLA005336-PA;APLA005231-PA;APLA000427-PA;APLA009708-PA;APLA005565-PA;APLA002878-PA KEGG: 00830+1.1.1.1 Retinol metabolism 1 APLA001970-PA KEGG: 04658+3.1.3.16 Th1 and Th2 cell differentiation 33 APLA002857-PA;APLA011704-PA;APLA011993-PA;APLA009999-PA;APLA002510-PA;APLA012551-PA;APLA012635-PA;APLA000289-PA;APLA005060-PA;APLA000004-PA;APLA000291-PA;APLA002573-PA;APLA014831-PA;APLA003839-PA;APLA012875-PA;APLA000158-PA;APLA000967-PA;APLA000398-PA;APLA009814-PA;APLA003696-PA;APLA009304-PA;APLA007805-PA;APLA005888-PA;APLA012854-PA;APLA004000-PA;APLA013338-PA;APLA001038-PA;APLA014024-PA;APLA009552-PA;APLA013081-PA;APLA001974-PA;APLA002665-PA;APLA005349-PA Reactome: R-HSA-1489509 DAG and IP3 signaling 1 APLA003653-PA MetaCyc: PWY-7625 Phosphatidylinositol biosynthesis II (eukaryotes) 1 APLA010033-PA Reactome: R-HSA-5662702 Melanin biosynthesis 4 APLA009136-PA;APLA011863-PA;APLA014431-PA;APLA011864-PA Reactome: R-HSA-1253288 Downregulation of ERBB4 signaling 2 APLA002288-PA;APLA014272-PA Reactome: R-HSA-480985 Synthesis of dolichyl-phosphate-glucose 3 APLA013381-PA;APLA001232-PA;APLA004210-PA KEGG: 00500+5.3.1.9 Starch and sucrose metabolism 1 APLA014015-PA Reactome: R-HSA-4086398 Ca2+ pathway 13 APLA014130-PA;APLA013701-PA;APLA013702-PA;APLA004792-PA;APLA010350-PA;APLA000332-PA;APLA003653-PA;APLA012153-PA;APLA003047-PA;APLA008458-PA;APLA009193-PA;APLA006554-PA;APLA009856-PA Reactome: R-HSA-1234174 Cellular response to hypoxia 2 APLA012166-PA;APLA000125-PA Reactome: R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 10 APLA005953-PA;APLA002288-PA;APLA007136-PA;APLA006113-PA;APLA014272-PA;APLA014713-PA;APLA006117-PA;APLA008497-PA;APLA009966-PA;APLA008509-PA KEGG: 00240+6.3.4.2 Pyrimidine metabolism 1 APLA010349-PA KEGG: 00720+1.3.5.1 Carbon fixation pathways in prokaryotes 5 APLA000357-PA;APLA013330-PA;APLA006254-PA;APLA015489-PA;APLA003262-PA KEGG: 00030+1.1.1.44 Pentose phosphate pathway 2 APLA012900-PA;APLA012905-PA MetaCyc: PWY-6932 Selenate reduction 1 APLA000768-PA Reactome: R-HSA-9649948 Signaling downstream of RAS mutants 3 APLA001451-PA;APLA002140-PA;APLA007030-PA MetaCyc: PWY-6731 Starch degradation III 2 APLA006828-PA;APLA006822-PA Reactome: R-HSA-5663220 RHO GTPases Activate Formins 45 APLA013547-PA;APLA006691-PA;APLA013357-PA;APLA007858-PA;APLA012338-PA;APLA014048-PA;APLA008446-PA;APLA010196-PA;APLA003480-PA;APLA014850-PA;APLA014772-PA;APLA004850-PA;APLA009417-PA;APLA015058-PA;APLA010643-PA;APLA002883-PA;APLA004639-PA;APLA001704-PA;APLA001953-PA;APLA001633-PA;APLA013359-PA;APLA002455-PA;APLA014679-PA;APLA001351-PA;APLA000427-PA;APLA002856-PA;APLA005242-PA;APLA002551-PA;APLA010596-PA;APLA007552-PA;APLA014998-PA;APLA001683-PA;APLA002909-PA;APLA011986-PA;APLA002859-PA;APLA000426-PA;APLA009660-PA;APLA010198-PA;APLA015416-PA;APLA004383-PA;APLA010197-PA;APLA015031-PA;APLA014307-PA;APLA001833-PA;APLA002135-PA MetaCyc: PWY-1722 Formate assimilation into 5,10-methylenetetrahydrofolate 2 APLA005730-PA;APLA005741-PA Reactome: R-HSA-917977 Transferrin endocytosis and recycling 18 APLA008018-PA;APLA000056-PA;APLA000114-PA;APLA005327-PA;APLA000368-PA;APLA004385-PA;APLA010311-PA;APLA007060-PA;APLA008019-PA;APLA003280-PA;APLA006015-PA;APLA002666-PA;APLA013217-PA;APLA006357-PA;APLA001263-PA;APLA008022-PA;APLA015217-PA;APLA008016-PA MetaCyc: PWY-6920 6-gingerol analog biosynthesis (engineered) 2 APLA013190-PA;APLA003250-PA MetaCyc: PWY-7094 Fatty acid salvage 4 APLA000468-PA;APLA006174-PA;APLA014896-PA;APLA006178-PA KEGG: 00970+6.1.1.21 Aminoacyl-tRNA biosynthesis 1 APLA002172-PA Reactome: R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 51 APLA013359-PA;APLA004504-PA;APLA010460-PA;APLA002551-PA;APLA010596-PA;APLA014998-PA;APLA011713-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA008686-PA;APLA010198-PA;APLA001601-PA;APLA013968-PA;APLA004383-PA;APLA015416-PA;APLA010197-PA;APLA005704-PA;APLA015031-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA000126-PA;APLA008836-PA;APLA008987-PA;APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA013357-PA;APLA014016-PA;APLA007858-PA;APLA012338-PA;APLA010196-PA;APLA008446-PA;APLA014048-PA;APLA013223-PA;APLA015028-PA;APLA014850-PA;APLA012977-PA;APLA012593-PA;APLA009417-PA;APLA005719-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA001953-PA;APLA006943-PA KEGG: 00073+2.3.1.20 Cutin, suberine and wax biosynthesis 2 APLA000150-PA;APLA000151-PA MetaCyc: PWY-7883 Anhydromuropeptides recycling II 6 APLA006026-PA;APLA002044-PA;APLA012599-PA;APLA001187-PA;APLA003010-PA;APLA010555-PA MetaCyc: PWY-5054 D-sorbitol biosynthesis I 1 APLA014015-PA KEGG: 00410+2.6.1.19 beta-Alanine metabolism 1 APLA003896-PA KEGG: 00511+3.2.1.25 Other glycan degradation 2 APLA001673-PA;APLA001817-PA Reactome: R-HSA-446203 Asparagine N-linked glycosylation 5 APLA002360-PA;APLA006000-PA;APLA012978-PA;APLA001067-PA;APLA009951-PA KEGG: 00513+2.4.1.131 Various types of N-glycan biosynthesis 1 APLA006458-PA Reactome: R-HSA-112308 Presynaptic depolarization and calcium channel opening 2 APLA009388-PA;APLA003033-PA Reactome: R-HSA-4719360 Defective DPM3 causes DPM3-CDG (CDG-1o) 2 APLA013212-PA;APLA006452-PA Reactome: R-HSA-71288 Creatine metabolism 3 APLA005600-PA;APLA000324-PA;APLA002184-PA KEGG: 05170+2.7.11.1 Human immunodeficiency virus 1 infection 35 APLA012309-PA;APLA014094-PA;APLA003559-PA;APLA014007-PA;APLA009561-PA;APLA010535-PA;APLA010570-PA;APLA002693-PA;APLA006659-PA;APLA014655-PA;APLA001541-PA;APLA003690-PA;APLA008080-PA;APLA001451-PA;APLA015343-PA;APLA005251-PA;APLA009103-PA;APLA011480-PA;APLA003517-PA;APLA011336-PA;APLA012070-PA;APLA013745-PA;APLA011405-PA;APLA008151-PA;APLA006656-PA;APLA005789-PA;APLA005614-PA;APLA005545-PA;APLA005222-PA;APLA006809-PA;APLA004865-PA;APLA002024-PA;APLA014432-PA;APLA000202-PA;APLA009255-PA Reactome: R-HSA-1483101 Synthesis of PS 1 APLA014464-PA Reactome: R-HSA-5659996 RPIA deficiency: failed conversion of R5P to RU5P 1 APLA000025-PA KEGG: 00730+3.6.1.15 Thiamine metabolism 1 APLA001305-PA Reactome: R-HSA-209543 p75NTR recruits signalling complexes 2 APLA014272-PA;APLA002288-PA KEGG: 00230+4.3.2.2 Purine metabolism 1 APLA007491-PA KEGG: 00513+2.4.1.68 Various types of N-glycan biosynthesis 2 APLA014868-PA;APLA014869-PA Reactome: R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 3 APLA010150-PA;APLA008115-PA;APLA001793-PA Reactome: R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 40 APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA006943-PA;APLA014003-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA005756-PA;APLA007872-PA;APLA010347-PA;APLA013223-PA;APLA015028-PA;APLA000940-PA;APLA005264-PA;APLA005017-PA;APLA012977-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA001313-PA;APLA014016-PA;APLA003055-PA;APLA008836-PA;APLA000126-PA;APLA011706-PA;APLA006975-PA;APLA000810-PA;APLA008987-PA;APLA001601-PA;APLA013968-PA;APLA011713-PA;APLA011005-PA;APLA000806-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA010460-PA;APLA004504-PA KEGG: 00680+4.1.2.13 Methane metabolism 2 APLA000565-PA;APLA000619-PA KEGG: 00270+1.1.1.37 Cysteine and methionine metabolism 3 APLA015456-PA;APLA000684-PA;APLA005378-PA MetaCyc: PWY-7663 Gondoate biosynthesis (anaerobic) 3 APLA007857-PA;APLA002545-PA;APLA002072-PA KEGG: 00030+5.3.1.9 Pentose phosphate pathway 1 APLA014015-PA Reactome: R-HSA-416482 G alpha (12/13) signalling events 12 APLA014624-PA;APLA005249-PA;APLA009858-PA;APLA009180-PA;APLA003300-PA;APLA006672-PA;APLA010856-PA;APLA003127-PA;APLA014622-PA;APLA009177-PA;APLA014439-PA;APLA008080-PA KEGG: 00970+6.3.5.7 Aminoacyl-tRNA biosynthesis 6 APLA001288-PA;APLA015017-PA;APLA004372-PA;APLA000397-PA;APLA001289-PA;APLA011722-PA Reactome: R-HSA-177504 Retrograde neurotrophin signalling 2 APLA008115-PA;APLA001793-PA MetaCyc: PWY-6471 Peptidoglycan biosynthesis IV (Enterococcus faecium) 2 APLA002213-PA;APLA009515-PA MetaCyc: PWY-5076 L-leucine degradation III 2 APLA001970-PA;APLA006327-PA Reactome: R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 9 APLA007932-PA;APLA008790-PA;APLA002968-PA;APLA014472-PA;APLA014272-PA;APLA010435-PA;APLA009488-PA;APLA004572-PA;APLA002288-PA Reactome: R-HSA-71032 Propionyl-CoA catabolism 1 APLA007201-PA Reactome: R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 20 APLA013703-PA;APLA014037-PA;APLA001551-PA;APLA002937-PA;APLA001456-PA;APLA003046-PA;APLA002938-PA;APLA003842-PA;APLA015000-PA;APLA014024-PA;APLA009185-PA;APLA000743-PA;APLA008108-PA;APLA014999-PA;APLA014520-PA;APLA003187-PA;APLA006899-PA;APLA008112-PA;APLA000547-PA;APLA006924-PA KEGG: 00220+6.3.1.2 Arginine biosynthesis 1 APLA000323-PA KEGG: 00720+6.2.1.5 Carbon fixation pathways in prokaryotes 5 APLA002458-PA;APLA014289-PA;APLA010449-PA;APLA004846-PA;APLA001878-PA MetaCyc: PWY-6118 Glycerol-3-phosphate shuttle 2 APLA015323-PA;APLA008272-PA Reactome: R-HSA-5357905 Regulation of TNFR1 signaling 3 APLA006858-PA;APLA002288-PA;APLA014272-PA MetaCyc: PWY-6538 Caffeine degradation III (bacteria, via demethylation) 1 APLA002333-PA KEGG: 00564+3.1.1.4 Glycerophospholipid metabolism 6 APLA009078-PA;APLA004469-PA;APLA009079-PA;APLA012384-PA;APLA005748-PA;APLA005749-PA Reactome: R-HSA-389513 CTLA4 inhibitory signaling 2 APLA001633-PA;APLA003480-PA KEGG: 00760+2.7.1.23 Nicotinate and nicotinamide metabolism 2 APLA013222-PA;APLA011044-PA MetaCyc: PWY-6361 1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3) 1 APLA014683-PA Reactome: R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 3 APLA001514-PA;APLA001648-PA;APLA011837-PA KEGG: 04151+2.7.1.153 PI3K-Akt signaling pathway 1 APLA002528-PA Reactome: R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 1 APLA000043-PA MetaCyc: PWY-4984 Urea cycle 1 APLA010889-PA KEGG: 00500+3.2.1.1 Starch and sucrose metabolism 3 APLA007993-PA;APLA001295-PA;APLA001296-PA Reactome: R-HSA-418597 G alpha (z) signalling events 7 APLA003037-PA;APLA003039-PA;APLA007417-PA;APLA007416-PA;APLA005245-PA;APLA014278-PA;APLA013400-PA Reactome: R-HSA-1483166 Synthesis of PA 17 APLA008272-PA;APLA012686-PA;APLA009816-PA;APLA007623-PA;APLA004542-PA;APLA005749-PA;APLA004147-PA;APLA008027-PA;APLA008024-PA;APLA005748-PA;APLA015323-PA;APLA002667-PA;APLA014471-PA;APLA009079-PA;APLA011460-PA;APLA004469-PA;APLA000543-PA KEGG: 00510+2.4.1.258 N-Glycan biosynthesis 1 APLA014717-PA Reactome: R-HSA-71262 Carnitine synthesis 2 APLA005867-PA;APLA009139-PA MetaCyc: PWY-6289 Petrobactin biosynthesis 1 APLA001971-PA MetaCyc: PWY-5469 Sesamin biosynthesis 1 APLA014196-PA MetaCyc: PWY-6433 Hydroxylated fatty acid biosynthesis (plants) 14 APLA010067-PA;APLA010064-PA;APLA010062-PA;APLA000863-PA;APLA010063-PA;APLA008114-PA;APLA000862-PA;APLA009871-PA;APLA010068-PA;APLA005258-PA;APLA002710-PA;APLA010066-PA;APLA015433-PA;APLA010065-PA KEGG: 00230+2.7.4.8 Purine metabolism 5 APLA015112-PA;APLA011621-PA;APLA005391-PA;APLA005232-PA;APLA002558-PA Reactome: R-HSA-912631 Regulation of signaling by CBL 4 APLA014272-PA;APLA012421-PA;APLA002288-PA;APLA009992-PA Reactome: R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 11 APLA009187-PA;APLA013309-PA;APLA000209-PA;APLA006367-PA;APLA011260-PA;APLA004532-PA;APLA009230-PA;APLA012675-PA;APLA001105-PA;APLA001404-PA;APLA004611-PA Reactome: R-HSA-113418 Formation of the Early Elongation Complex 26 APLA010986-PA;APLA014037-PA;APLA013703-PA;APLA000879-PA;APLA001551-PA;APLA002937-PA;APLA002938-PA;APLA003046-PA;APLA001456-PA;APLA003279-PA;APLA003842-PA;APLA015000-PA;APLA014024-PA;APLA009185-PA;APLA000743-PA;APLA008108-PA;APLA014999-PA;APLA009703-PA;APLA014520-PA;APLA003187-PA;APLA001596-PA;APLA008112-PA;APLA006899-PA;APLA001624-PA;APLA000547-PA;APLA006924-PA KEGG: 00230+2.7.4.10 Purine metabolism 1 APLA006751-PA MetaCyc: PWY-7117 C4 photosynthetic carbon assimilation cycle, PEPCK type 5 APLA012983-PA;APLA012145-PA;APLA002692-PA;APLA008850-PA;APLA014966-PA MetaCyc: PWY-6313 Serotonin degradation 1 APLA001970-PA KEGG: 00230+4.6.1.2 Purine metabolism 9 APLA001125-PA;APLA001123-PA;APLA008917-PA;APLA001413-PA;APLA004212-PA;APLA015356-PA;APLA001410-PA;APLA005797-PA;APLA013622-PA Reactome: R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 11 APLA000853-PA;APLA002383-PA;APLA014443-PA;APLA004312-PA;APLA006643-PA;APLA007938-PA;APLA012887-PA;APLA007822-PA;APLA002169-PA;APLA004738-PA;APLA002908-PA Reactome: R-HSA-156588 Glucuronidation 29 APLA011360-PA;APLA011361-PA;APLA000614-PA;APLA000328-PA;APLA006991-PA;APLA014746-PA;APLA014747-PA;APLA009995-PA;APLA003100-PA;APLA006986-PA;APLA001350-PA;APLA004698-PA;APLA001846-PA;APLA001562-PA;APLA006992-PA;APLA007750-PA;APLA014744-PA;APLA006251-PA;APLA014743-PA;APLA004250-PA;APLA006990-PA;APLA011141-PA;APLA000613-PA;APLA014742-PA;APLA004697-PA;APLA006993-PA;APLA006988-PA;APLA006989-PA;APLA002237-PA Reactome: R-HSA-5576893 Phase 2 - plateau phase 7 APLA005630-PA;APLA011359-PA;APLA008885-PA;APLA009388-PA;APLA008887-PA;APLA014672-PA;APLA003527-PA Reactome: R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 16 APLA015058-PA;APLA006060-PA;APLA004137-PA;APLA011447-PA;APLA001290-PA;APLA002444-PA;APLA003482-PA;APLA010643-PA;APLA009708-PA;APLA000427-PA;APLA005565-PA;APLA002878-PA;APLA000426-PA;APLA005336-PA;APLA005231-PA;APLA011986-PA MetaCyc: PWY-6907 Thiamine diphosphate biosynthesis III (Staphylococcus) 1 APLA005503-PA Reactome: R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis 1 APLA013710-PA Reactome: R-HSA-8951936 RUNX3 regulates p14-ARF 2 APLA008489-PA;APLA008490-PA Reactome: R-HSA-428890 Role of ABL in ROBO-SLIT signaling 1 APLA012417-PA KEGG: 00260+1.4.4.2 Glycine, serine and threonine metabolism 1 APLA002656-PA Reactome: R-HSA-6787639 GDP-fucose biosynthesis 4 APLA005576-PA;APLA009161-PA;APLA009143-PA;APLA014427-PA Reactome: R-HSA-8849175 Threonine catabolism 4 APLA005402-PA;APLA000169-PA;APLA002058-PA;APLA008971-PA Reactome: R-HSA-193648 NRAGE signals death through JNK 10 APLA009180-PA;APLA015161-PA;APLA005249-PA;APLA014624-PA;APLA014439-PA;APLA009177-PA;APLA014622-PA;APLA003127-PA;APLA010856-PA;APLA006672-PA Reactome: R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 33 APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA006943-PA;APLA002428-PA;APLA002873-PA;APLA014272-PA;APLA001313-PA;APLA006607-PA;APLA014016-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA001601-PA;APLA013968-PA;APLA008836-PA;APLA000126-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008987-PA;APLA004504-PA;APLA010460-PA;APLA011713-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA008686-PA KEGG: 00591+3.1.1.4 Linoleic acid metabolism 7 APLA005748-PA;APLA005749-PA;APLA004469-PA;APLA009078-PA;APLA009079-PA;APLA001975-PA;APLA012384-PA KEGG: 00051+4.1.2.13 Fructose and mannose metabolism 2 APLA000565-PA;APLA000619-PA Reactome: R-HSA-426496 Post-transcriptional silencing by small RNAs 5 APLA014130-PA;APLA013701-PA;APLA013702-PA;APLA003047-PA;APLA009856-PA Reactome: R-HSA-72163 mRNA Splicing - Major Pathway 85 APLA014037-PA;APLA001916-PA;APLA014921-PA;APLA001717-PA;APLA003602-PA;APLA007722-PA;APLA007133-PA;APLA003046-PA;APLA014042-PA;APLA004191-PA;APLA001949-PA;APLA003842-PA;APLA002689-PA;APLA001533-PA;APLA014430-PA;APLA012013-PA;APLA014999-PA;APLA005669-PA;APLA001551-PA;APLA002359-PA;APLA006330-PA;APLA003382-PA;APLA010569-PA;APLA002938-PA;APLA009518-PA;APLA008229-PA;APLA000807-PA;APLA008108-PA;APLA009973-PA;APLA012011-PA;APLA008956-PA;APLA003196-PA;APLA000176-PA;APLA000816-PA;APLA012612-PA;APLA008112-PA;APLA002484-PA;APLA002126-PA;APLA011577-PA;APLA008643-PA;APLA012071-PA;APLA000929-PA;APLA008014-PA;APLA004454-PA;APLA015384-PA;APLA007670-PA;APLA000465-PA;APLA004346-PA;APLA008788-PA;APLA012128-PA;APLA002937-PA;APLA004851-PA;APLA001716-PA;APLA014520-PA;APLA000320-PA;APLA001417-PA;APLA008204-PA;APLA000249-PA;APLA009098-PA;APLA001836-PA;APLA013703-PA;APLA013813-PA;APLA012976-PA;APLA004415-PA;APLA000699-PA;APLA007536-PA;APLA010675-PA;APLA007873-PA;APLA014338-PA;APLA003076-PA;APLA000743-PA;APLA015000-PA;APLA006970-PA;APLA005894-PA;APLA015233-PA;APLA011282-PA;APLA004976-PA;APLA009489-PA;APLA006974-PA;APLA006899-PA;APLA000631-PA;APLA004737-PA;APLA013024-PA;APLA015322-PA;APLA010637-PA MetaCyc: PWY-8004 Entner-Doudoroff pathway I 14 APLA010497-PA;APLA015268-PA;APLA010500-PA;APLA006779-PA;APLA003817-PA;APLA000788-PA;APLA007679-PA;APLA007919-PA;APLA003818-PA;APLA004744-PA;APLA007488-PA;APLA005622-PA;APLA000476-PA;APLA010499-PA KEGG: 00590+5.3.99.3 Arachidonic acid metabolism 1 APLA000186-PA KEGG: 00720+4.2.1.3 Carbon fixation pathways in prokaryotes 1 APLA008464-PA KEGG: 00520+2.7.7.12 Amino sugar and nucleotide sugar metabolism 1 APLA001518-PA KEGG: 00052+3.2.1.22 Galactose metabolism 5 APLA007466-PA;APLA007468-PA;APLA007538-PA;APLA007467-PA;APLA007164-PA KEGG: 00330+1.14.11.2 Arginine and proline metabolism 1 APLA011609-PA Reactome: R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 4 APLA011446-PA;APLA001457-PA;APLA001596-PA;APLA005348-PA Reactome: R-HSA-8949613 Cristae formation 25 APLA004887-PA;APLA009120-PA;APLA004852-PA;APLA008779-PA;APLA005153-PA;APLA004886-PA;APLA004095-PA;APLA013473-PA;APLA004097-PA;APLA012585-PA;APLA003759-PA;APLA013770-PA;APLA015214-PA;APLA000012-PA;APLA008521-PA;APLA007966-PA;APLA015229-PA;APLA011684-PA;APLA014283-PA;APLA003989-PA;APLA008781-PA;APLA011304-PA;APLA003430-PA;APLA005788-PA;APLA004746-PA Reactome: R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 15 APLA014037-PA;APLA013703-PA;APLA001551-PA;APLA002219-PA;APLA005703-PA;APLA000113-PA;APLA003046-PA;APLA000743-PA;APLA012594-PA;APLA009711-PA;APLA005113-PA;APLA005484-PA;APLA008215-PA;APLA012887-PA;APLA007938-PA Reactome: R-HSA-418457 cGMP effects 5 APLA000332-PA;APLA008458-PA;APLA010350-PA;APLA004792-PA;APLA012153-PA KEGG: 00010+1.2.4.1 Glycolysis / Gluconeogenesis 2 APLA001487-PA;APLA005998-PA KEGG: 00480+1.17.4.1 Glutathione metabolism 2 APLA001267-PA;APLA012574-PA Reactome: R-HSA-1369007 Mitochondrial ABC transporters 1 APLA000690-PA Reactome: R-HSA-8964539 Glutamate and glutamine metabolism 9 APLA011286-PA;APLA001395-PA;APLA004042-PA;APLA007436-PA;APLA008941-PA;APLA004043-PA;APLA000323-PA;APLA001945-PA;APLA007435-PA Reactome: R-HSA-5358346 Hedgehog ligand biogenesis 36 APLA008790-PA;APLA010460-PA;APLA004504-PA;APLA011713-PA;APLA009873-PA;APLA008686-PA;APLA004494-PA;APLA013844-PA;APLA015189-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA008987-PA;APLA009411-PA;APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA014016-PA;APLA013223-PA;APLA015028-PA;APLA012977-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA005756-PA;APLA010347-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA006943-PA Reactome: R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 2 APLA006305-PA;APLA012421-PA Reactome: R-HSA-68884 Mitotic Telophase/Cytokinesis 1 APLA011337-PA Reactome: R-HSA-390648 Muscarinic acetylcholine receptors 2 APLA004068-PA;APLA004393-PA KEGG: 00903+4.2.1.17 Limonene and pinene degradation 4 APLA000468-PA;APLA006174-PA;APLA014896-PA;APLA006178-PA Reactome: R-HSA-212436 Generic Transcription Pathway 19 APLA008337-PA;APLA005955-PA;APLA006663-PA;APLA007823-PA;APLA010312-PA;APLA000204-PA;APLA004459-PA;APLA008186-PA;APLA006660-PA;APLA004845-PA;APLA008274-PA;APLA003383-PA;APLA006664-PA;APLA008217-PA;APLA013198-PA;APLA010662-PA;APLA006662-PA;APLA010275-PA;APLA002451-PA Reactome: R-HSA-8940973 RUNX2 regulates osteoblast differentiation 3 APLA008490-PA;APLA002140-PA;APLA008489-PA KEGG: 00970+6.1.1.9 Aminoacyl-tRNA biosynthesis 2 APLA002820-PA;APLA000185-PA MetaCyc: PWY-7119 Ceramide and sphingolipid recycling and degradation (yeast) 1 APLA004099-PA MetaCyc: PWY-3661 Glycine betaine degradation I 1 APLA000499-PA MetaCyc: PWY-7379 Mrna capping II 1 APLA003794-PA MetaCyc: PWY-4261 Glycerol degradation I 6 APLA008272-PA;APLA002336-PA;APLA015323-PA;APLA005715-PA;APLA011491-PA;APLA000317-PA Reactome: R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 11 APLA009504-PA;APLA004700-PA;APLA001514-PA;APLA010443-PA;APLA009499-PA;APLA004353-PA;APLA009503-PA;APLA008519-PA;APLA009193-PA;APLA011837-PA;APLA007972-PA KEGG: 00071+1.3.3.6 Fatty acid degradation 2 APLA013190-PA;APLA003250-PA MetaCyc: PWY-5855 Ubiquinol-7 biosynthesis (prokaryotic) 1 APLA002418-PA KEGG: 00010+1.8.1.4 Glycolysis / Gluconeogenesis 1 APLA003939-PA Reactome: R-HSA-196108 Pregnenolone biosynthesis 4 APLA010534-PA;APLA007957-PA;APLA002948-PA;APLA008939-PA MetaCyc: PWY-7384 Anaerobic energy metabolism (invertebrates, mitochondrial) 7 APLA001878-PA;APLA003089-PA;APLA007201-PA;APLA002458-PA;APLA014289-PA;APLA010449-PA;APLA004846-PA Reactome: R-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI) 14 APLA004622-PA;APLA009112-PA;APLA001839-PA;APLA006774-PA;APLA009097-PA;APLA009709-PA;APLA010787-PA;APLA006773-PA;APLA012889-PA;APLA006902-PA;APLA003820-PA;APLA009661-PA;APLA012149-PA;APLA006867-PA MetaCyc: PWY-6679 Jadomycin biosynthesis 1 APLA013496-PA Reactome: R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 1 APLA007157-PA MetaCyc: PWY-6892 Thiazole biosynthesis I (facultative anaerobic bacteria) 1 APLA003487-PA KEGG: 00565+3.1.4.4 Ether lipid metabolism 1 APLA011460-PA Reactome: R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 10 APLA005811-PA;APLA008244-PA;APLA005738-PA;APLA007491-PA;APLA005740-PA;APLA012530-PA;APLA007847-PA;APLA008936-PA;APLA008935-PA;APLA003519-PA Reactome: R-HSA-373753 Nephrin family interactions 3 APLA002486-PA;APLA000068-PA;APLA001292-PA KEGG: 00710+3.1.3.11 Carbon fixation in photosynthetic organisms 1 APLA009512-PA Reactome: R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1) 1 APLA000270-PA Reactome: R-HSA-912446 Meiotic recombination 14 APLA009662-PA;APLA008808-PA;APLA006643-PA;APLA006644-PA;APLA009324-PA;APLA000469-PA;APLA009590-PA;APLA014545-PA;APLA003193-PA;APLA005929-PA;APLA002832-PA;APLA005141-PA;APLA002432-PA;APLA014443-PA KEGG: 00514+2.4.1.255 Other types of O-glycan biosynthesis 1 APLA009371-PA Reactome: R-HSA-163765 ChREBP activates metabolic gene expression 6 APLA002547-PA;APLA007857-PA;APLA013496-PA;APLA001878-PA;APLA002072-PA;APLA002545-PA KEGG: 00051+3.1.3.11 Fructose and mannose metabolism 1 APLA009512-PA MetaCyc: PWY-6606 Guanosine nucleotides degradation II 2 APLA002333-PA;APLA002282-PA KEGG: 00950+2.6.1.5 Isoquinoline alkaloid biosynthesis 1 APLA013125-PA KEGG: 00900+2.1.1.100 Terpenoid backbone biosynthesis 1 APLA003058-PA Reactome: R-HSA-1482801 Acyl chain remodelling of PS 4 APLA009079-PA;APLA004469-PA;APLA005748-PA;APLA005749-PA MetaCyc: PWY-4841 UDP-alpha-D-glucuronate biosynthesis (from myo-inositol) 1 APLA006233-PA KEGG: 00220+3.5.3.1 Arginine biosynthesis 1 APLA010889-PA KEGG: 00780+6.3.4.15 Biotin metabolism 1 APLA002544-PA MetaCyc: PWY-5340 Sulfate activation for sulfonation 1 APLA000768-PA MetaCyc: PWY-6837 Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent) 2 APLA013190-PA;APLA003250-PA Reactome: R-HSA-4641257 Degradation of AXIN 34 APLA013223-PA;APLA015028-PA;APLA012977-PA;APLA001313-PA;APLA002428-PA;APLA014272-PA;APLA002873-PA;APLA001168-PA;APLA014016-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA006943-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA011713-PA;APLA004494-PA;APLA013844-PA;APLA015189-PA;APLA008686-PA;APLA004504-PA;APLA010460-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA008987-PA;APLA001601-PA;APLA013968-PA;APLA005704-PA KEGG: 00020+4.2.1.2 Citrate cycle (TCA cycle) 1 APLA003089-PA Reactome: R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 3 APLA014029-PA;APLA012902-PA;APLA012906-PA MetaCyc: PWY-5870 Ubiquinol-8 biosynthesis (eukaryotic) 1 APLA002418-PA Reactome: R-HSA-9637628 Modulation by Mtb of host immune system 2 APLA002288-PA;APLA014272-PA Reactome: R-HSA-177929 Signaling by EGFR 2 APLA007945-PA;APLA005011-PA MetaCyc: PWY-5972 Stearate biosynthesis I (animals) 12 APLA010063-PA;APLA000863-PA;APLA010062-PA;APLA010064-PA;APLA010067-PA;APLA010065-PA;APLA015433-PA;APLA010066-PA;APLA002710-PA;APLA009871-PA;APLA010068-PA;APLA000862-PA MetaCyc: PWY-6803 Phosphatidylcholine acyl editing 10 APLA001975-PA;APLA005749-PA;APLA012865-PA;APLA005748-PA;APLA002539-PA;APLA008047-PA;APLA004469-PA;APLA009078-PA;APLA009079-PA;APLA012384-PA Reactome: R-HSA-73780 RNA Polymerase III Chain Elongation 13 APLA000113-PA;APLA002219-PA;APLA005703-PA;APLA001551-PA;APLA013703-PA;APLA014037-PA;APLA009711-PA;APLA005113-PA;APLA005484-PA;APLA000743-PA;APLA012594-PA;APLA008215-PA;APLA003046-PA Reactome: R-HSA-5467337 APC truncation mutants have impaired AXIN binding 3 APLA001633-PA;APLA010601-PA;APLA003480-PA KEGG: 00710+1.2.1.12 Carbon fixation in photosynthetic organisms 3 APLA007488-PA;APLA007679-PA;APLA000476-PA KEGG: 00730+2.7.6.2 Thiamine metabolism 1 APLA005503-PA Reactome: R-HSA-5668599 RHO GTPases Activate NADPH Oxidases 2 APLA002140-PA;APLA000777-PA MetaCyc: PWY-7214 Baicalein degradation (hydrogen peroxide detoxification) 1 APLA014196-PA Reactome: R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins 1 APLA003669-PA MetaCyc: PWY-5136 Fatty acid beta-oxidation II (plant peroxisome) 6 APLA006178-PA;APLA003250-PA;APLA014896-PA;APLA013190-PA;APLA006174-PA;APLA000468-PA KEGG: 00520+2.6.1.16 Amino sugar and nucleotide sugar metabolism 1 APLA007020-PA Reactome: R-HSA-418592 ADP signalling through P2Y purinoceptor 1 1 APLA007917-PA MetaCyc: PWY-7734 Quinoxaline-2-carboxylate biosynthesis 1 APLA005085-PA Reactome: R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 9 APLA014841-PA;APLA014545-PA;APLA002832-PA;APLA005929-PA;APLA003193-PA;APLA001691-PA;APLA005141-PA;APLA012406-PA;APLA013151-PA KEGG: 00052+2.7.7.12 Galactose metabolism 1 APLA001518-PA Reactome: R-HSA-432047 Passive transport by Aquaporins 14 APLA009375-PA;APLA006782-PA;APLA000951-PA;APLA009374-PA;APLA004794-PA;APLA004795-PA;APLA008930-PA;APLA013331-PA;APLA004793-PA;APLA012999-PA;APLA006785-PA;APLA000950-PA;APLA004796-PA;APLA011145-PA Reactome: R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 1 APLA013745-PA KEGG: 04070+2.7.1.153 Phosphatidylinositol signaling system 1 APLA002528-PA KEGG: 00710+2.6.1.1 Carbon fixation in photosynthetic organisms 2 APLA012983-PA;APLA012145-PA KEGG: 00230+2.7.4.6 Purine metabolism 3 APLA000359-PA;APLA009372-PA;APLA002995-PA Reactome: R-HSA-195253 Degradation of beta-catenin by the destruction complex 38 APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA010601-PA;APLA006943-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA014016-PA;APLA006607-PA;APLA001313-PA;APLA014272-PA;APLA002428-PA;APLA002873-PA;APLA003480-PA;APLA012977-PA;APLA015028-PA;APLA013223-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA004504-PA;APLA010460-PA;APLA003316-PA;APLA001633-PA;APLA008686-PA;APLA004494-PA;APLA013844-PA;APLA015189-PA;APLA011713-PA Reactome: R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 5 APLA010637-PA;APLA015233-PA;APLA002937-PA;APLA005894-PA;APLA002938-PA MetaCyc: PWY-7805 (aminomethyl)phosphonate degradation 2 APLA001349-PA;APLA008549-PA Reactome: R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 1 APLA002001-PA MetaCyc: PWY-6952 Glycerophosphodiester degradation 2 APLA015323-PA;APLA008272-PA Reactome: R-HSA-1250196 SHC1 events in ERBB2 signaling 1 APLA006305-PA Reactome: R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 17 APLA012489-PA;APLA009719-PA;APLA005703-PA;APLA001551-PA;APLA002219-PA;APLA013703-PA;APLA014037-PA;APLA008215-PA;APLA005113-PA;APLA000743-PA;APLA007912-PA;APLA003046-PA;APLA000113-PA;APLA009711-PA;APLA007139-PA;APLA005484-PA;APLA012594-PA MetaCyc: PWY-6883 Pyruvate fermentation to butanol II (engineered) 4 APLA006178-PA;APLA014896-PA;APLA006174-PA;APLA000468-PA KEGG: 00562+5.5.1.4 Inositol phosphate metabolism 1 APLA012083-PA MetaCyc: PWY-6871 3-methylbutanol biosynthesis (engineered) 1 APLA001970-PA Reactome: R-HSA-71064 Lysine catabolism 4 APLA007481-PA;APLA002644-PA;APLA005733-PA;APLA003939-PA Reactome: R-HSA-388841 Costimulation by the CD28 family 1 APLA012421-PA MetaCyc: PWY-7400 L-arginine biosynthesis IV (archaebacteria) 1 APLA002345-PA Reactome: R-HSA-8854691 Interleukin-20 family signaling 2 APLA003587-PA;APLA003586-PA KEGG: 00680+4.2.1.11 Methane metabolism 4 APLA010499-PA;APLA010497-PA;APLA010500-PA;APLA007919-PA Reactome: R-HSA-937042 IRAK2 mediated activation of TAK1 complex 2 APLA014272-PA;APLA002288-PA MetaCyc: PWY-7863 Roseoflavin biosynthesis 1 APLA014390-PA Reactome: R-HSA-2206282 MPS IIIB - Sanfilippo syndrome B 1 APLA007458-PA Reactome: R-HSA-6804758 Regulation of TP53 Activity through Acetylation 3 APLA005952-PA;APLA007577-PA;APLA005702-PA Reactome: R-HSA-159227 Transport of the SLBP independent Mature mRNA 18 APLA001290-PA;APLA011447-PA;APLA015058-PA;APLA004137-PA;APLA006060-PA;APLA002937-PA;APLA002444-PA;APLA002938-PA;APLA010643-PA;APLA003482-PA;APLA002878-PA;APLA005565-PA;APLA009708-PA;APLA000427-PA;APLA005336-PA;APLA005231-PA;APLA000426-PA;APLA011986-PA KEGG: 00970+6.1.1.18 Aminoacyl-tRNA biosynthesis 1 APLA000131-PA KEGG: 00270+5.3.1.23 Cysteine and methionine metabolism 4 APLA013006-PA;APLA001529-PA;APLA011701-PA;APLA004190-PA Reactome: R-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins 1 APLA002271-PA MetaCyc: PWY-7942 5-oxo-L-proline metabolism 3 APLA010672-PA;APLA013647-PA;APLA009968-PA MetaCyc: PWY-6348 Phosphate acquisition 1 APLA000700-PA MetaCyc: PWY-922 Mevalonate pathway I 4 APLA007166-PA;APLA000828-PA;APLA001403-PA;APLA012425-PA Reactome: R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 10 APLA009217-PA;APLA009349-PA;APLA011994-PA;APLA008961-PA;APLA014028-PA;APLA007739-PA;APLA014519-PA;APLA005863-PA;APLA003087-PA;APLA010202-PA MetaCyc: PWY-7347 Sucrose biosynthesis III 1 APLA014015-PA Reactome: R-HSA-210500 Glutamate Neurotransmitter Release Cycle 1 APLA007949-PA KEGG: 00630+6.3.1.2 Glyoxylate and dicarboxylate metabolism 1 APLA000323-PA Reactome: R-HSA-3000497 Scavenging by Class H Receptors 3 APLA003678-PA;APLA002555-PA;APLA003544-PA KEGG: 00500+2.4.1.18 Starch and sucrose metabolism 4 APLA007993-PA;APLA003655-PA;APLA001296-PA;APLA001295-PA KEGG: 00790+2.10.1.1 Folate biosynthesis 1 APLA009260-PA Reactome: R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration 2 APLA008489-PA;APLA008490-PA KEGG: 00230+1.7.3.3 Purine metabolism 1 APLA010841-PA Reactome: R-HSA-201688 WNT mediated activation of DVL 1 APLA012840-PA Reactome: R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 1 APLA002559-PA Reactome: R-HSA-5576886 Phase 4 - resting membrane potential 9 APLA005493-PA;APLA011128-PA;APLA009483-PA;APLA014245-PA;APLA003720-PA;APLA009232-PA;APLA008675-PA;APLA005919-PA;APLA009554-PA Reactome: R-HSA-3656237 Defective EXT2 causes exostoses 2 6 APLA011087-PA;APLA011086-PA;APLA013952-PA;APLA011893-PA;APLA011085-PA;APLA011894-PA Reactome: R-HSA-77387 Insulin receptor recycling 18 APLA008019-PA;APLA004385-PA;APLA000368-PA;APLA010311-PA;APLA007060-PA;APLA005327-PA;APLA000114-PA;APLA000056-PA;APLA008018-PA;APLA008016-PA;APLA015217-PA;APLA006357-PA;APLA001263-PA;APLA013217-PA;APLA008022-PA;APLA002666-PA;APLA006015-PA;APLA003280-PA Reactome: R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision) 1 APLA000730-PA MetaCyc: PWY-6370 Ascorbate recycling (cytosolic) 1 APLA014577-PA MetaCyc: PWY-7340 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast) 2 APLA003250-PA;APLA013190-PA Reactome: R-HSA-6787450 tRNA modification in the mitochondrion 6 APLA004551-PA;APLA005825-PA;APLA013811-PA;APLA009445-PA;APLA014022-PA;APLA002127-PA Reactome: R-HSA-1237112 Methionine salvage pathway 4 APLA009072-PA;APLA014335-PA;APLA013006-PA;APLA001298-PA Reactome: R-HSA-2206305 MPS IIID - Sanfilippo syndrome D 1 APLA005913-PA Reactome: R-HSA-2132295 MHC class II antigen presentation 44 APLA001000-PA;APLA015241-PA;APLA010885-PA;APLA010198-PA;APLA001793-PA;APLA004383-PA;APLA011337-PA;APLA004453-PA;APLA015416-PA;APLA010197-PA;APLA015031-PA;APLA014536-PA;APLA001323-PA;APLA002583-PA;APLA010513-PA;APLA005365-PA;APLA013359-PA;APLA004714-PA;APLA008827-PA;APLA005368-PA;APLA003237-PA;APLA002551-PA;APLA010596-PA;APLA000220-PA;APLA014998-PA;APLA009417-PA;APLA015228-PA;APLA009501-PA;APLA008115-PA;APLA001587-PA;APLA003210-PA;APLA001953-PA;APLA008946-PA;APLA006345-PA;APLA013357-PA;APLA003633-PA;APLA012338-PA;APLA007858-PA;APLA008446-PA;APLA014048-PA;APLA010196-PA;APLA014850-PA;APLA007154-PA;APLA000549-PA Reactome: R-HSA-5578749 Transcriptional regulation by small RNAs 24 APLA000426-PA;APLA005231-PA;APLA005336-PA;APLA011986-PA;APLA005565-PA;APLA002878-PA;APLA009708-PA;APLA014520-PA;APLA000427-PA;APLA002444-PA;APLA003482-PA;APLA010643-PA;APLA003046-PA;APLA003842-PA;APLA000743-PA;APLA011447-PA;APLA001290-PA;APLA013703-PA;APLA014037-PA;APLA015058-PA;APLA008660-PA;APLA006060-PA;APLA004137-PA;APLA001551-PA KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35 Fatty acid degradation 1 APLA000468-PA Reactome: R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 11 APLA001407-PA;APLA014725-PA;APLA000454-PA;APLA002288-PA;APLA005195-PA;APLA008872-PA;APLA002707-PA;APLA003608-PA;APLA003018-PA;APLA002236-PA;APLA014272-PA Reactome: R-HSA-203754 NOSIP mediated eNOS trafficking 1 APLA011369-PA Reactome: R-HSA-8963901 Chylomicron remodeling 3 APLA003678-PA;APLA002555-PA;APLA003544-PA Reactome: R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 6 APLA014770-PA;APLA012569-PA;APLA001487-PA;APLA008824-PA;APLA003939-PA;APLA005998-PA MetaCyc: PWY-7761 NAD salvage pathway II (PNC IV cycle) 2 APLA012508-PA;APLA002192-PA KEGG: 00790+4.6.1.17 Folate biosynthesis 1 APLA008006-PA MetaCyc: PWY-7388 Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) 3 APLA007857-PA;APLA002545-PA;APLA002072-PA KEGG: 00270+1.13.11.54 Cysteine and methionine metabolism 1 APLA001298-PA Reactome: R-HSA-8957275 Post-translational protein phosphorylation 8 APLA002555-PA;APLA003678-PA;APLA009488-PA;APLA003544-PA;APLA008693-PA;APLA004700-PA;APLA005245-PA;APLA007932-PA KEGG: 00760+3.1.3.5 Nicotinate and nicotinamide metabolism 1 APLA002282-PA KEGG: 00930+3.1.1.17 Caprolactam degradation 1 APLA005270-PA Reactome: R-HSA-6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 1 APLA008988-PA KEGG: 00860+2.5.1.17 Porphyrin and chlorophyll metabolism 1 APLA012988-PA Reactome: R-HSA-71403 Citric acid cycle (TCA cycle) 26 APLA005733-PA;APLA010449-PA;APLA003089-PA;APLA011579-PA;APLA010376-PA;APLA003713-PA;APLA001878-PA;APLA008464-PA;APLA003939-PA;APLA000357-PA;APLA002458-PA;APLA002375-PA;APLA014289-PA;APLA003710-PA;APLA009900-PA;APLA000684-PA;APLA015489-PA;APLA006254-PA;APLA000059-PA;APLA009901-PA;APLA013330-PA;APLA004846-PA;APLA001137-PA;APLA012845-PA;APLA003262-PA;APLA000905-PA Reactome: R-HSA-2995383 Initiation of Nuclear Envelope Reformation 1 APLA009431-PA MetaCyc: PWY-7601 Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes) 14 APLA010067-PA;APLA000863-PA;APLA008114-PA;APLA010063-PA;APLA010064-PA;APLA010062-PA;APLA010068-PA;APLA009871-PA;APLA000862-PA;APLA010066-PA;APLA015433-PA;APLA010065-PA;APLA005258-PA;APLA002710-PA Reactome: R-HSA-8941326 RUNX2 regulates bone development 2 APLA008490-PA;APLA008489-PA MetaCyc: PWY-6598 Sciadonate biosynthesis 14 APLA005258-PA;APLA002710-PA;APLA010066-PA;APLA010065-PA;APLA015433-PA;APLA000862-PA;APLA009871-PA;APLA010068-PA;APLA010064-PA;APLA010062-PA;APLA000863-PA;APLA008114-PA;APLA010063-PA;APLA010067-PA MetaCyc: PWY-7279 Aerobic respiration II (cytochrome c) (yeast) 6 APLA000357-PA;APLA013330-PA;APLA000133-PA;APLA003262-PA;APLA015489-PA;APLA006254-PA MetaCyc: PWY-6788 Cellulose degradation II (fungi) 5 APLA011824-PA;APLA007751-PA;APLA007753-PA;APLA011825-PA;APLA005900-PA KEGG: 00565+3.1.3.4 Ether lipid metabolism 1 APLA001595-PA Reactome: R-HSA-9009391 Extra-nuclear estrogen signaling 1 APLA012421-PA Reactome: R-HSA-4043916 Defective MPI causes MPI-CDG (CDG-1b) 1 APLA004325-PA Reactome: R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 5 APLA014443-PA;APLA001840-PA;APLA000830-PA;APLA004368-PA;APLA006643-PA Reactome: R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 41 APLA005017-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA005264-PA;APLA000940-PA;APLA014016-PA;APLA003055-PA;APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA014003-PA;APLA006943-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA007872-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA011005-PA;APLA011713-PA;APLA000806-PA;APLA010460-PA;APLA004504-PA;APLA008987-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA MetaCyc: PWY-6902 Chitin degradation II (Vibrio) 14 APLA012599-PA;APLA007660-PA;APLA003813-PA;APLA002044-PA;APLA001426-PA;APLA003440-PA;APLA001187-PA;APLA003546-PA;APLA001425-PA;APLA015396-PA;APLA006026-PA;APLA010555-PA;APLA003010-PA;APLA005525-PA MetaCyc: PWY-381 Nitrate reduction II (assimilatory) 1 APLA000323-PA KEGG: 00561+2.7.1.30 Glycerolipid metabolism 4 APLA005715-PA;APLA002336-PA;APLA000317-PA;APLA011491-PA KEGG: 00230+2.7.6.1 Purine metabolism 2 APLA009863-PA;APLA013710-PA KEGG: 00480+4.3.2.7 Glutathione metabolism 2 APLA009968-PA;APLA010672-PA MetaCyc: PWY-4202 Arsenate detoxification I (mammalian) 2 APLA013738-PA;APLA000262-PA Reactome: R-HSA-5627117 RHO GTPases Activate ROCKs 1 APLA008080-PA Reactome: R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 15 APLA002938-PA;APLA008112-PA;APLA003046-PA;APLA006899-PA;APLA002937-PA;APLA000743-PA;APLA003842-PA;APLA015000-PA;APLA014037-PA;APLA013703-PA;APLA008108-PA;APLA001551-PA;APLA014520-PA;APLA011060-PA;APLA014999-PA KEGG: 00071+1.1.1.1 Fatty acid degradation 1 APLA001970-PA Reactome: R-HSA-1482798 Acyl chain remodeling of CL 1 APLA003393-PA Reactome: R-HSA-196299 Beta-catenin phosphorylation cascade 3 APLA010601-PA;APLA003480-PA;APLA001633-PA MetaCyc: PWY-5531 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) 1 APLA008197-PA MetaCyc: PWY-5133 Colupulone and cohumulone biosynthesis 2 APLA006387-PA;APLA008135-PA Reactome: R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 1 APLA015204-PA Reactome: R-HSA-383280 Nuclear Receptor transcription pathway 34 APLA003557-PA;APLA001906-PA;APLA014161-PA;APLA002834-PA;APLA001775-PA;APLA006721-PA;APLA008838-PA;APLA003558-PA;APLA007205-PA;APLA009835-PA;APLA010074-PA;APLA010632-PA;APLA008839-PA;APLA000859-PA;APLA001041-PA;APLA004822-PA;APLA001905-PA;APLA013767-PA;APLA004459-PA;APLA006720-PA;APLA003009-PA;APLA014162-PA;APLA015072-PA;APLA002838-PA;APLA001973-PA;APLA007620-PA;APLA012215-PA;APLA009832-PA;APLA006359-PA;APLA015371-PA;APLA007971-PA;APLA008297-PA;APLA009834-PA;APLA009342-PA KEGG: 00564+1.1.5.3 Glycerophospholipid metabolism 2 APLA015323-PA;APLA008272-PA KEGG: 00970+6.1.1.1 Aminoacyl-tRNA biosynthesis 2 APLA002864-PA;APLA004281-PA Reactome: R-HSA-9018519 Estrogen-dependent gene expression 24 APLA014520-PA;APLA014999-PA;APLA008490-PA;APLA013701-PA;APLA014130-PA;APLA008108-PA;APLA013702-PA;APLA011837-PA;APLA007145-PA;APLA009856-PA;APLA006899-PA;APLA008112-PA;APLA001514-PA;APLA004459-PA;APLA001551-PA;APLA013703-PA;APLA014037-PA;APLA008489-PA;APLA003047-PA;APLA000743-PA;APLA015000-PA;APLA003842-PA;APLA003046-PA;APLA003680-PA MetaCyc: PWY-6771 Rhamnogalacturonan type I degradation II (bacteria) 11 APLA007097-PA;APLA003882-PA;APLA007093-PA;APLA003884-PA;APLA003886-PA;APLA007086-PA;APLA003881-PA;APLA007091-PA;APLA012442-PA;APLA003883-PA;APLA007096-PA KEGG: 04714+2.7.11.1 Thermogenesis 35 APLA001541-PA;APLA010535-PA;APLA010570-PA;APLA002693-PA;APLA006659-PA;APLA014655-PA;APLA014007-PA;APLA003559-PA;APLA009561-PA;APLA012309-PA;APLA014094-PA;APLA012070-PA;APLA011336-PA;APLA011405-PA;APLA013745-PA;APLA008151-PA;APLA005251-PA;APLA009103-PA;APLA003517-PA;APLA011480-PA;APLA001451-PA;APLA008080-PA;APLA015343-PA;APLA003690-PA;APLA005614-PA;APLA005789-PA;APLA006656-PA;APLA000202-PA;APLA009255-PA;APLA002024-PA;APLA014432-PA;APLA006809-PA;APLA004865-PA;APLA005545-PA;APLA005222-PA KEGG: 00380+2.3.1.61 Tryptophan metabolism 1 APLA005733-PA KEGG: 00860+1.16.3.1 Porphyrin and chlorophyll metabolism 2 APLA010815-PA;APLA012657-PA KEGG: 00520+4.2.1.47 Amino sugar and nucleotide sugar metabolism 2 APLA009161-PA;APLA009143-PA Reactome: R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 22 APLA014998-PA;APLA007858-PA;APLA012338-PA;APLA014048-PA;APLA008446-PA;APLA010196-PA;APLA014850-PA;APLA009144-PA;APLA013359-PA;APLA002551-PA;APLA002988-PA;APLA010596-PA;APLA013357-PA;APLA015031-PA;APLA003259-PA;APLA001953-PA;APLA009417-PA;APLA010198-PA;APLA015416-PA;APLA004383-PA;APLA007030-PA;APLA010197-PA KEGG: 00521+2.7.1.1 Streptomycin biosynthesis 2 APLA002389-PA;APLA001397-PA KEGG: 00051+5.3.1.1 Fructose and mannose metabolism 1 APLA006547-PA KEGG: 00860+2.5.1.61 Porphyrin and chlorophyll metabolism 1 APLA008273-PA Reactome: R-HSA-6793080 rRNA modification in the mitochondrion 2 APLA002046-PA;APLA003197-PA KEGG: 00640+1.2.1.27 Propanoate metabolism 1 APLA000040-PA Reactome: R-HSA-3295583 TRP channels 5 APLA005667-PA;APLA005665-PA;APLA003605-PA;APLA001565-PA;APLA006570-PA MetaCyc: PWY-5103 L-isoleucine biosynthesis III 1 APLA006327-PA KEGG: 00790+3.5.4.16 Folate biosynthesis 1 APLA006918-PA KEGG: 00280+1.2.1.27 Valine, leucine and isoleucine degradation 1 APLA000040-PA Reactome: R-HSA-918233 TRAF3-dependent IRF activation pathway 3 APLA001514-PA;APLA011103-PA;APLA011837-PA Reactome: R-HSA-111463 SMAC (DIABLO) binds to IAPs 3 APLA009882-PA;APLA009642-PA;APLA013736-PA KEGG: 00410+4.2.1.17 beta-Alanine metabolism 4 APLA006174-PA;APLA014896-PA;APLA006178-PA;APLA000468-PA KEGG: 00473+5.1.1.1 D-Alanine metabolism 1 APLA014952-PA KEGG: 00564+2.3.1.15 Glycerophospholipid metabolism 2 APLA002667-PA;APLA009816-PA Reactome: R-HSA-5686938 Regulation of TLR by endogenous ligand 3 APLA003678-PA;APLA002555-PA;APLA003544-PA KEGG: 00240+3.5.4.12 Pyrimidine metabolism 1 APLA014612-PA Reactome: R-HSA-1679131 Trafficking and processing of endosomal TLR 1 APLA010513-PA KEGG: 00051+2.7.1.105+3.1.3.46 Fructose and mannose metabolism 2 APLA003264-PA;APLA009770-PA Reactome: R-HSA-5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 5 APLA008829-PA;APLA008830-PA;APLA007256-PA;APLA007157-PA;APLA007255-PA MetaCyc: PWY-7778 2-methylpropene degradation 4 APLA006178-PA;APLA014896-PA;APLA006174-PA;APLA000468-PA KEGG: 05165+2.7.11.1 Human papillomavirus infection 35 APLA009561-PA;APLA003559-PA;APLA014007-PA;APLA012309-PA;APLA014094-PA;APLA001541-PA;APLA014655-PA;APLA010535-PA;APLA010570-PA;APLA002693-PA;APLA006659-PA;APLA015343-PA;APLA001451-PA;APLA008080-PA;APLA003690-PA;APLA008151-PA;APLA012070-PA;APLA011336-PA;APLA013745-PA;APLA011405-PA;APLA003517-PA;APLA011480-PA;APLA005251-PA;APLA009103-PA;APLA005789-PA;APLA006656-PA;APLA005614-PA;APLA004865-PA;APLA006809-PA;APLA005222-PA;APLA005545-PA;APLA000202-PA;APLA009255-PA;APLA002024-PA;APLA014432-PA MetaCyc: PWY-7179-1 Purine deoxyribonucleosides degradation II 5 APLA015153-PA;APLA013738-PA;APLA000262-PA;APLA006728-PA;APLA006726-PA Reactome: R-HSA-69052 Switching of origins to a post-replicative state 8 APLA010598-PA;APLA006933-PA;APLA001307-PA;APLA001388-PA;APLA008611-PA;APLA014775-PA;APLA011532-PA;APLA008613-PA MetaCyc: PWY-6829 Trna methylation (yeast) 8 APLA013678-PA;APLA004905-PA;APLA007954-PA;APLA002352-PA;APLA001203-PA;APLA010314-PA;APLA012987-PA;APLA005323-PA Reactome: R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 6 APLA006673-PA;APLA000633-PA;APLA013196-PA;APLA010173-PA;APLA014355-PA;APLA014833-PA MetaCyc: PWY-6142 Gluconeogenesis II (Methanobacterium thermoautotrophicum) 13 APLA010497-PA;APLA010500-PA;APLA015268-PA;APLA013385-PA;APLA014966-PA;APLA000619-PA;APLA000565-PA;APLA007919-PA;APLA008850-PA;APLA002692-PA;APLA014015-PA;APLA010499-PA;APLA006547-PA Reactome: R-HSA-6785470 tRNA processing in the mitochondrion 4 APLA005825-PA;APLA001197-PA;APLA001199-PA;APLA007127-PA Reactome: R-HSA-181429 Serotonin Neurotransmitter Release Cycle 3 APLA002651-PA;APLA002653-PA;APLA007949-PA Reactome: R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 2 APLA005305-PA;APLA005245-PA Reactome: R-HSA-6785631 ERBB2 Regulates Cell Motility 2 APLA008466-PA;APLA006305-PA KEGG: 00983+2.7.4.14 Drug metabolism - other enzymes 1 APLA014549-PA KEGG: 00330+2.6.1.1 Arginine and proline metabolism 2 APLA012983-PA;APLA012145-PA MetaCyc: PWY-7765 3-hydroxy-4-methyl-anthranilate biosynthesis II 2 APLA001933-PA;APLA005085-PA Reactome: R-HSA-388844 Receptor-type tyrosine-protein phosphatases 2 APLA007949-PA;APLA014069-PA MetaCyc: PWY-7902 Glucosylglycerol biosynthesis 1 APLA008024-PA MetaCyc: PWY-6613 Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 3 APLA005741-PA;APLA005811-PA;APLA005730-PA MetaCyc: PWY-7230 Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast) 1 APLA002418-PA KEGG: 00550+2.7.8.13 Peptidoglycan biosynthesis 1 APLA002213-PA KEGG: 00860+2.3.1.37 Porphyrin and chlorophyll metabolism 1 APLA010645-PA MetaCyc: PWY-6607 Guanosine nucleotides degradation I 2 APLA002333-PA;APLA002282-PA KEGG: 00010+4.1.1.32 Glycolysis / Gluconeogenesis 1 APLA013213-PA Reactome: R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 10 APLA006738-PA;APLA006696-PA;APLA009515-PA;APLA005568-PA;APLA006458-PA;APLA014717-PA;APLA002213-PA;APLA009657-PA;APLA004988-PA;APLA003772-PA Reactome: R-HSA-1227986 Signaling by ERBB2 2 APLA009848-PA;APLA006305-PA KEGG: 00270+1.1.1.27 Cysteine and methionine metabolism 2 APLA000737-PA;APLA000736-PA Reactome: R-HSA-75955 RNA Polymerase II Transcription Elongation 34 APLA014999-PA;APLA001596-PA;APLA014520-PA;APLA011795-PA;APLA009703-PA;APLA003048-PA;APLA005278-PA;APLA009092-PA;APLA006924-PA;APLA002009-PA;APLA000879-PA;APLA014037-PA;APLA010986-PA;APLA003842-PA;APLA003279-PA;APLA009185-PA;APLA005321-PA;APLA003046-PA;APLA008984-PA;APLA003187-PA;APLA008108-PA;APLA000547-PA;APLA007972-PA;APLA006899-PA;APLA001624-PA;APLA008112-PA;APLA001551-PA;APLA013703-PA;APLA015000-PA;APLA008519-PA;APLA000743-PA;APLA014024-PA;APLA001456-PA;APLA009107-PA Reactome: R-HSA-70350 Fructose catabolism 2 APLA011326-PA;APLA005654-PA KEGG: 00052+5.1.3.3 Galactose metabolism 2 APLA015199-PA;APLA012066-PA Reactome: R-HSA-1251985 Nuclear signaling by ERBB4 4 APLA007945-PA;APLA007136-PA;APLA014713-PA;APLA005953-PA Reactome: R-HSA-2029485 Role of phospholipids in phagocytosis 3 APLA011460-PA;APLA014442-PA;APLA003653-PA KEGG: 00332+2.7.2.11 Carbapenem biosynthesis 1 APLA007435-PA Reactome: R-HSA-174414 Processive synthesis on the C-strand of the telomere 3 APLA013151-PA;APLA001691-PA;APLA014841-PA Reactome: R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds 3 APLA009874-PA;APLA015192-PA;APLA008714-PA Reactome: R-HSA-71737 Pyrophosphate hydrolysis 1 APLA001349-PA KEGG: 00260+2.3.1.37 Glycine, serine and threonine metabolism 1 APLA010645-PA Reactome: R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 2 APLA008490-PA;APLA008489-PA MetaCyc: PWY-6277 Superpathway of 5-aminoimidazole ribonucleotide biosynthesis 3 APLA005811-PA;APLA012530-PA;APLA008936-PA KEGG: 00250+1.4.1.14 Alanine, aspartate and glutamate metabolism 1 APLA002704-PA MetaCyc: PWY-7892 Trna-uridine 2-thiolation and selenation (bacteria) 1 APLA014022-PA Reactome: R-HSA-73863 RNA Polymerase I Transcription Termination 16 APLA014136-PA;APLA000630-PA;APLA003311-PA;APLA001624-PA;APLA009703-PA;APLA001596-PA;APLA009344-PA;APLA000743-PA;APLA003279-PA;APLA003046-PA;APLA005703-PA;APLA001551-PA;APLA000879-PA;APLA010986-PA;APLA014037-PA;APLA013703-PA Reactome: R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 27 APLA001596-PA;APLA014520-PA;APLA009703-PA;APLA002404-PA;APLA003196-PA;APLA014272-PA;APLA001624-PA;APLA011412-PA;APLA001194-PA;APLA001551-PA;APLA014921-PA;APLA015384-PA;APLA000879-PA;APLA013703-PA;APLA014037-PA;APLA010986-PA;APLA013813-PA;APLA002124-PA;APLA004465-PA;APLA012424-PA;APLA000743-PA;APLA003842-PA;APLA003279-PA;APLA014197-PA;APLA003046-PA;APLA008788-PA;APLA002288-PA Reactome: R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 17 APLA013151-PA;APLA004368-PA;APLA005141-PA;APLA006016-PA;APLA002790-PA;APLA001691-PA;APLA003193-PA;APLA014272-PA;APLA010387-PA;APLA014545-PA;APLA014841-PA;APLA000884-PA;APLA002288-PA;APLA008283-PA;APLA001459-PA;APLA002832-PA;APLA005000-PA KEGG: 00330+2.5.1.16 Arginine and proline metabolism 2 APLA003859-PA;APLA000590-PA Reactome: R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 2 APLA008489-PA;APLA008490-PA KEGG: 00230+4.1.1.21 Purine metabolism 1 APLA008935-PA KEGG: 00460+2.1.2.1 Cyanoamino acid metabolism 1 APLA000499-PA KEGG: 00970+6.1.1.19 Aminoacyl-tRNA biosynthesis 2 APLA006680-PA;APLA012591-PA Reactome: R-HSA-5334118 DNA methylation 2 APLA004194-PA;APLA005906-PA MetaCyc: PWY-7174 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II 4 APLA004190-PA;APLA011701-PA;APLA001529-PA;APLA013006-PA KEGG: 00604+3.2.1.23 Glycosphingolipid biosynthesis - ganglio series 5 APLA004972-PA;APLA001673-PA;APLA001817-PA;APLA004969-PA;APLA005795-PA Reactome: R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 8 APLA011005-PA;APLA005264-PA;APLA000806-PA;APLA000940-PA;APLA014003-PA;APLA005017-PA;APLA007872-PA;APLA003055-PA MetaCyc: PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) 2 APLA014683-PA;APLA003180-PA MetaCyc: PWY-7999 Vitamin K-epoxide cycle 2 APLA003042-PA;APLA003040-PA Reactome: R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 16 APLA006339-PA;APLA006341-PA;APLA004183-PA;APLA009588-PA;APLA004174-PA;APLA004171-PA;APLA011061-PA;APLA001921-PA;APLA004182-PA;APLA004173-PA;APLA004588-PA;APLA004184-PA;APLA004582-PA;APLA015327-PA;APLA004175-PA;APLA004172-PA MetaCyc: PWY-5461 Betanidin degradation 1 APLA014196-PA Reactome: R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 33 APLA005819-PA;APLA015031-PA;APLA010197-PA;APLA005586-PA;APLA015416-PA;APLA007925-PA;APLA004383-PA;APLA010198-PA;APLA012012-PA;APLA001935-PA;APLA014998-PA;APLA010596-PA;APLA002551-PA;APLA006385-PA;APLA013359-PA;APLA001953-PA;APLA003528-PA;APLA011572-PA;APLA007920-PA;APLA014601-PA;APLA009417-PA;APLA014850-PA;APLA008446-PA;APLA014048-PA;APLA010196-PA;APLA012196-PA;APLA007858-PA;APLA012338-PA;APLA013357-PA;APLA007146-PA;APLA011862-PA;APLA004877-PA;APLA011959-PA Reactome: R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 2 APLA008490-PA;APLA008489-PA MetaCyc: PWY-8052 2-arachidonoylglycerol biosynthesis 6 APLA006557-PA;APLA014442-PA;APLA003808-PA;APLA012536-PA;APLA006554-PA;APLA001595-PA Reactome: R-HSA-163282 Mitochondrial transcription initiation 1 APLA005772-PA Reactome: R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 7 APLA007407-PA;APLA006554-PA;APLA014442-PA;APLA012536-PA;APLA003808-PA;APLA003180-PA;APLA006557-PA KEGG: 00230+1.17.1.4 Purine metabolism 1 APLA002333-PA MetaCyc: PWY-7216 (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) 4 APLA006178-PA;APLA014896-PA;APLA006174-PA;APLA000468-PA Reactome: R-HSA-75109 Triglyceride biosynthesis 1 APLA001595-PA Reactome: R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 4 APLA002403-PA;APLA000830-PA;APLA001840-PA;APLA004356-PA KEGG: 00600+1.14.19.17 Sphingolipid metabolism 1 APLA001711-PA KEGG: 00030+1.1.1.47 Pentose phosphate pathway 1 APLA014154-PA Reactome: R-HSA-8875555 MET activates RAP1 and RAC1 1 APLA009992-PA Reactome: R-HSA-975577 N-Glycan antennae elongation 3 APLA000479-PA;APLA002535-PA;APLA014804-PA KEGG: 00520+1.1.1.22 Amino sugar and nucleotide sugar metabolism 1 APLA005458-PA Reactome: R-HSA-114508 Effects of PIP2 hydrolysis 6 APLA011740-PA;APLA011921-PA;APLA012308-PA;APLA003653-PA;APLA013224-PA;APLA006190-PA MetaCyc: PWY-5331 Taurine biosynthesis I 1 APLA004739-PA Reactome: R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 5 APLA006233-PA;APLA007407-PA;APLA012083-PA;APLA008242-PA;APLA002096-PA KEGG: 00281+4.2.1.17+1.1.1.35 Geraniol degradation 4 APLA006174-PA;APLA014896-PA;APLA006178-PA;APLA000468-PA MetaCyc: PWY-5669 Phosphatidylserine and phosphatidylethanolamine biosynthesis I 1 APLA009513-PA Reactome: R-HSA-5656121 Translesion synthesis by POLI 13 APLA014545-PA;APLA010387-PA;APLA000884-PA;APLA005000-PA;APLA014841-PA;APLA005141-PA;APLA014272-PA;APLA001459-PA;APLA002832-PA;APLA003193-PA;APLA002790-PA;APLA001691-PA;APLA002288-PA MetaCyc: PWY-6580 Phosphatidylinositol biosynthesis I (bacteria) 1 APLA012083-PA MetaCyc: PWY-3861 Mannitol degradation II 1 APLA004325-PA KEGG: 00562+1.13.99.1 Inositol phosphate metabolism 1 APLA006233-PA KEGG: 00030+2.7.6.1 Pentose phosphate pathway 2 APLA009863-PA;APLA013710-PA MetaCyc: PWY-4041 Gamma-glutamyl cycle 3 APLA004285-PA;APLA004293-PA;APLA004294-PA MetaCyc: PWY-6983 Threo-tetrahydrobiopterin biosynthesis 1 APLA006918-PA MetaCyc: PWY-5664 Erythro-tetrahydrobiopterin biosynthesis II 1 APLA006918-PA Reactome: R-HSA-174411 Polymerase switching on the C-strand of the telomere 13 APLA013151-PA;APLA006690-PA;APLA008659-PA;APLA014513-PA;APLA001691-PA;APLA002790-PA;APLA001459-PA;APLA010387-PA;APLA007371-PA;APLA005000-PA;APLA014841-PA;APLA008612-PA;APLA000884-PA Reactome: R-HSA-9604323 Negative regulation of NOTCH4 signaling 33 APLA014016-PA;APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA006607-PA;APLA012977-PA;APLA015028-PA;APLA013223-PA;APLA010347-PA;APLA005756-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA006943-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA004504-PA;APLA010460-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA008686-PA;APLA011713-PA;APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA000126-PA;APLA008836-PA Reactome: R-HSA-3000480 Scavenging by Class A Receptors 3 APLA003678-PA;APLA002555-PA;APLA003544-PA Reactome: R-HSA-5654700 FRS-mediated FGFR2 signaling 1 APLA005551-PA KEGG: 00524+2.7.1.1 Neomycin, kanamycin and gentamicin biosynthesis 2 APLA002389-PA;APLA001397-PA KEGG: 00250+4.3.2.2 Alanine, aspartate and glutamate metabolism 1 APLA007491-PA KEGG: 00860+4.4.1.17 Porphyrin and chlorophyll metabolism 2 APLA001797-PA;APLA001796-PA Reactome: R-HSA-525793 Myogenesis 5 APLA004850-PA;APLA004070-PA;APLA006758-PA;APLA004072-PA;APLA001710-PA MetaCyc: PWY-7821 Tunicamycin biosynthesis 3 APLA002282-PA;APLA009005-PA;APLA009849-PA MetaCyc: PWY-6728 Methylaspartate cycle 16 APLA010449-PA;APLA003089-PA;APLA007201-PA;APLA005378-PA;APLA001878-PA;APLA000357-PA;APLA002458-PA;APLA014289-PA;APLA000684-PA;APLA015489-PA;APLA006254-PA;APLA013330-PA;APLA001137-PA;APLA004846-PA;APLA015456-PA;APLA003262-PA Reactome: R-HSA-416476 G alpha (q) signalling events 15 APLA014391-PA;APLA008313-PA;APLA007917-PA;APLA001458-PA;APLA001150-PA;APLA005274-PA;APLA002322-PA;APLA012421-PA;APLA012536-PA;APLA006557-PA;APLA014032-PA;APLA015481-PA;APLA006554-PA;APLA004098-PA;APLA000938-PA KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35 Butanoate metabolism 1 APLA000468-PA KEGG: 00330+2.7.2.11 Arginine and proline metabolism 1 APLA007435-PA Reactome: R-HSA-1296052 Ca2+ activated K+ channels 1 APLA010367-PA Reactome: R-HSA-2142700 Synthesis of Lipoxins (LX) 1 APLA003023-PA Reactome: R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 3 APLA002140-PA;APLA001451-PA;APLA007030-PA KEGG: 00250+2.6.1.16 Alanine, aspartate and glutamate metabolism 1 APLA007020-PA KEGG: 00600+3.2.1.22 Sphingolipid metabolism 5 APLA007468-PA;APLA007466-PA;APLA007538-PA;APLA007467-PA;APLA007164-PA Reactome: R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 2 APLA002288-PA;APLA014272-PA Reactome: R-HSA-379726 Mitochondrial tRNA aminoacylation 8 APLA005033-PA;APLA000131-PA;APLA011745-PA;APLA004820-PA;APLA011973-PA;APLA005238-PA;APLA006630-PA;APLA008083-PA Reactome: R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 1 APLA006607-PA KEGG: 00982+2.5.1.18 Drug metabolism - cytochrome P450 1 APLA014577-PA KEGG: 00970+6.1.1.4 Aminoacyl-tRNA biosynthesis 2 APLA009586-PA;APLA006630-PA KEGG: 00350+2.6.1.1 Tyrosine metabolism 2 APLA012145-PA;APLA012983-PA Reactome: R-HSA-8963693 Aspartate and asparagine metabolism 3 APLA012902-PA;APLA004354-PA;APLA012906-PA Reactome: R-HSA-9630221 Defective NTHL1 substrate processing 1 APLA001208-PA KEGG: 00250+6.3.4.4 Alanine, aspartate and glutamate metabolism 1 APLA007847-PA Reactome: R-HSA-8876725 Protein methylation 6 APLA009060-PA;APLA000123-PA;APLA009234-PA;APLA009359-PA;APLA001549-PA;APLA008790-PA Reactome: R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 5 APLA014130-PA;APLA013701-PA;APLA013702-PA;APLA003047-PA;APLA009856-PA MetaCyc: PWY-5912 2'-deoxymugineic acid phytosiderophore biosynthesis 1 APLA008908-PA MetaCyc: PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation 2 APLA002096-PA;APLA008242-PA KEGG: 00600+3.2.1.23 Sphingolipid metabolism 5 APLA005795-PA;APLA004972-PA;APLA001673-PA;APLA004969-PA;APLA001817-PA Reactome: R-HSA-193692 Regulated proteolysis of p75NTR 4 APLA007136-PA;APLA007945-PA;APLA005953-PA;APLA014713-PA Reactome: R-HSA-1855191 Synthesis of IPs in the nucleus 1 APLA014683-PA KEGG: 00680+1.1.1.284 Methane metabolism 1 APLA001970-PA Reactome: R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 1 APLA005551-PA MetaCyc: PWY-5142 Acyl-[acyl-carrier protein] thioesterase pathway 3 APLA002072-PA;APLA002545-PA;APLA007857-PA Reactome: R-HSA-983189 Kinesins 49 APLA000198-PA;APLA010011-PA;APLA009947-PA;APLA000850-PA;APLA013357-PA;APLA007067-PA;APLA007858-PA;APLA012338-PA;APLA008446-PA;APLA010196-PA;APLA005944-PA;APLA014048-PA;APLA007063-PA;APLA014850-PA;APLA005946-PA;APLA009417-PA;APLA003990-PA;APLA002181-PA;APLA000171-PA;APLA012208-PA;APLA011335-PA;APLA009093-PA;APLA000140-PA;APLA010448-PA;APLA004732-PA;APLA014986-PA;APLA001953-PA;APLA013359-PA;APLA004844-PA;APLA004714-PA;APLA007021-PA;APLA002551-PA;APLA005677-PA;APLA010596-PA;APLA014998-PA;APLA010110-PA;APLA010940-PA;APLA012207-PA;APLA012304-PA;APLA010198-PA;APLA014714-PA;APLA015416-PA;APLA004383-PA;APLA000849-PA;APLA011337-PA;APLA007638-PA;APLA010197-PA;APLA015031-PA;APLA013662-PA Reactome: R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 27 APLA009185-PA;APLA000743-PA;APLA014024-PA;APLA003842-PA;APLA015000-PA;APLA003279-PA;APLA001456-PA;APLA005321-PA;APLA003046-PA;APLA001551-PA;APLA000879-PA;APLA013703-PA;APLA010986-PA;APLA014037-PA;APLA006924-PA;APLA000547-PA;APLA001624-PA;APLA006899-PA;APLA008112-PA;APLA001596-PA;APLA014520-PA;APLA003187-PA;APLA011795-PA;APLA009703-PA;APLA014999-PA;APLA003048-PA;APLA008108-PA Reactome: R-HSA-6783984 Glycine degradation 5 APLA005967-PA;APLA003939-PA;APLA003749-PA;APLA002656-PA;APLA003152-PA Reactome: R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 3 APLA009882-PA;APLA009642-PA;APLA013736-PA KEGG: 00360+2.6.1.1 Phenylalanine metabolism 2 APLA012145-PA;APLA012983-PA MetaCyc: PWY-7807 Glyphosate degradation III 2 APLA001349-PA;APLA008549-PA Reactome: R-HSA-432142 Platelet sensitization by LDL 5 APLA002555-PA;APLA003678-PA;APLA001633-PA;APLA003480-PA;APLA003544-PA MetaCyc: PWY-5966-1 Fatty acid biosynthesis initiation (animals and fungi, cytoplasm) 4 APLA002545-PA;APLA002072-PA;APLA013496-PA;APLA007857-PA MetaCyc: PWY-7592 Arachidonate biosynthesis III (6-desaturase, mammals) 2 APLA008114-PA;APLA005258-PA Reactome: R-HSA-5578999 Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) 4 APLA003096-PA;APLA013161-PA;APLA003098-PA;APLA009670-PA MetaCyc: PWY-7919 Protein N-glycosylation processing phase (plants and animals) 1 APLA002968-PA Reactome: R-HSA-1236974 ER-Phagosome pathway 36 APLA008686-PA;APLA004494-PA;APLA013844-PA;APLA015189-PA;APLA011713-PA;APLA010460-PA;APLA004504-PA;APLA008510-PA;APLA008987-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA005704-PA;APLA003234-PA;APLA013968-PA;APLA001601-PA;APLA012977-PA;APLA015028-PA;APLA013223-PA;APLA014016-PA;APLA001313-PA;APLA002873-PA;APLA002428-PA;APLA014272-PA;APLA006943-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA005637-PA;APLA012593-PA;APLA005719-PA MetaCyc: PWY-7656 Spodoptera littoralis pheromone biosynthesis 13 APLA006178-PA;APLA006174-PA;APLA000726-PA;APLA000704-PA;APLA000539-PA;APLA003949-PA;APLA000545-PA;APLA014896-PA;APLA001864-PA;APLA002536-PA;APLA000540-PA;APLA000468-PA;APLA000546-PA MetaCyc: PWY-5196 Factor 430 biosynthesis 1 APLA003859-PA Reactome: R-HSA-9656256 Defective OGG1 Substrate Processing 1 APLA010076-PA KEGG: 00760+6.3.4.21 Nicotinate and nicotinamide metabolism 2 APLA012418-PA;APLA003120-PA Reactome: R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 2 APLA002288-PA;APLA014272-PA Reactome: R-HSA-3359471 Defective MMAB causes methylmalonic aciduria type cblB 1 APLA012988-PA Reactome: R-HSA-5620916 VxPx cargo-targeting to cilium 9 APLA012196-PA;APLA005819-PA;APLA001935-PA;APLA012012-PA;APLA004877-PA;APLA007146-PA;APLA007925-PA;APLA005586-PA;APLA007920-PA Reactome: R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 13 APLA014601-PA;APLA007498-PA;APLA009758-PA;APLA009150-PA;APLA010301-PA;APLA005545-PA;APLA014094-PA;APLA007731-PA;APLA007496-PA;APLA002692-PA;APLA008732-PA;APLA009658-PA;APLA010535-PA Reactome: R-HSA-196783 Coenzyme A biosynthesis 3 APLA007948-PA;APLA006625-PA;APLA015353-PA Reactome: R-HSA-71336 Pentose phosphate pathway 10 APLA000025-PA;APLA005084-PA;APLA008988-PA;APLA012900-PA;APLA012905-PA;APLA014461-PA;APLA013284-PA;APLA005079-PA;APLA005083-PA;APLA015453-PA Reactome: R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 6 APLA011087-PA;APLA011086-PA;APLA011085-PA;APLA011894-PA;APLA011893-PA;APLA013952-PA Reactome: R-HSA-167161 HIV Transcription Initiation 28 APLA011482-PA;APLA007145-PA;APLA012150-PA;APLA014646-PA;APLA000670-PA;APLA008112-PA;APLA001478-PA;APLA006899-PA;APLA001624-PA;APLA014999-PA;APLA009703-PA;APLA014520-PA;APLA001596-PA;APLA008108-PA;APLA003279-PA;APLA008290-PA;APLA005145-PA;APLA015000-PA;APLA003842-PA;APLA000743-PA;APLA005246-PA;APLA003046-PA;APLA000879-PA;APLA001551-PA;APLA012883-PA;APLA010986-PA;APLA014037-PA;APLA013703-PA Reactome: R-HSA-5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 5 APLA007256-PA;APLA007157-PA;APLA007255-PA;APLA008830-PA;APLA008829-PA Reactome: R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2 APLA014258-PA;APLA015205-PA Reactome: R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 3 APLA003082-PA;APLA010513-PA;APLA003085-PA Reactome: R-HSA-9022692 Regulation of MECP2 expression and activity 9 APLA015296-PA;APLA009856-PA;APLA003047-PA;APLA013702-PA;APLA013701-PA;APLA012596-PA;APLA014130-PA;APLA003943-PA;APLA007030-PA Reactome: R-HSA-425410 Metal ion SLC transporters 2 APLA005498-PA;APLA009117-PA MetaCyc: PWY-7053 Docosahexaenoate biosynthesis I (lower eukaryotes) 2 APLA008114-PA;APLA005258-PA KEGG: 00590+3.1.1.4 Arachidonic acid metabolism 7 APLA005748-PA;APLA005749-PA;APLA009078-PA;APLA004469-PA;APLA009079-PA;APLA001975-PA;APLA012384-PA MetaCyc: PWY-7822 Chitin degradation III (Serratia) 14 APLA006026-PA;APLA015396-PA;APLA003546-PA;APLA001425-PA;APLA001187-PA;APLA005525-PA;APLA003010-PA;APLA010555-PA;APLA002044-PA;APLA003440-PA;APLA001426-PA;APLA003813-PA;APLA007660-PA;APLA012599-PA KEGG: 00230+2.4.2.14 Purine metabolism 1 APLA008936-PA Reactome: R-HSA-428543 Inactivation of CDC42 and RAC1 1 APLA004850-PA Reactome: R-HSA-8951430 RUNX3 regulates WNT signaling 1 APLA009193-PA MetaCyc: PWY-7856 Heme a biosynthesis 1 APLA003714-PA KEGG: 00260+2.1.2.1 Glycine, serine and threonine metabolism 1 APLA000499-PA Reactome: R-HSA-428540 Activation of RAC1 3 APLA002486-PA;APLA009561-PA;APLA002693-PA MetaCyc: PWY-7920 Complex N-linked glycan biosynthesis (plants) 2 APLA012410-PA;APLA007125-PA KEGG: 00561+2.7.7.9 Glycerolipid metabolism 1 APLA003021-PA Reactome: R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 3 APLA011837-PA;APLA001514-PA;APLA012166-PA Reactome: R-HSA-8941858 Regulation of RUNX3 expression and activity 34 APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA000126-PA;APLA008836-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA008490-PA;APLA010460-PA;APLA004504-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA008686-PA;APLA011713-PA;APLA010347-PA;APLA005756-PA;APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA008489-PA;APLA006943-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA014016-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA001313-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA MetaCyc: PWY-6737 Starch degradation V 4 APLA006828-PA;APLA004011-PA;APLA006822-PA;APLA004009-PA Reactome: R-HSA-162791 Attachment of GPI anchor to uPAR 6 APLA005086-PA;APLA005605-PA;APLA008271-PA;APLA002483-PA;APLA014795-PA;APLA003428-PA KEGG: 00720+2.3.3.8 Carbon fixation pathways in prokaryotes 1 APLA001878-PA KEGG: 00061+6.4.1.2 Fatty acid biosynthesis 1 APLA013496-PA MetaCyc: PWY-6946 Cholesterol degradation to androstenedione II (cholesterol dehydrogenase) 4 APLA000468-PA;APLA014896-PA;APLA006178-PA;APLA006174-PA MetaCyc: PWY-6557 Glycosaminoglycan-protein linkage region biosynthesis 1 APLA008128-PA Reactome: R-HSA-352230 Amino acid transport across the plasma membrane 1 APLA008825-PA KEGG: 00030+5.1.3.1 Pentose phosphate pathway 1 APLA015453-PA KEGG: 00510+2.4.1.83 N-Glycan biosynthesis 1 APLA013212-PA Reactome: R-HSA-70370 Galactose catabolism 1 APLA001518-PA KEGG: 04660+3.1.3.16 T cell receptor signaling pathway 33 APLA011993-PA;APLA011704-PA;APLA002857-PA;APLA000004-PA;APLA005060-PA;APLA000289-PA;APLA009999-PA;APLA012551-PA;APLA002510-PA;APLA012635-PA;APLA002573-PA;APLA000291-PA;APLA014831-PA;APLA003839-PA;APLA000398-PA;APLA000158-PA;APLA000967-PA;APLA012875-PA;APLA005888-PA;APLA012854-PA;APLA009304-PA;APLA007805-PA;APLA009814-PA;APLA003696-PA;APLA014024-PA;APLA004000-PA;APLA001038-PA;APLA013338-PA;APLA002665-PA;APLA005349-PA;APLA001974-PA;APLA009552-PA;APLA013081-PA KEGG: 00900+4.1.1.33 Terpenoid backbone biosynthesis 1 APLA000828-PA KEGG: 00710+2.7.1.14 Carbon fixation in photosynthetic organisms 1 APLA013284-PA Reactome: R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 2 APLA011837-PA;APLA001514-PA Reactome: R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 6 APLA008988-PA;APLA013473-PA;APLA011061-PA;APLA014335-PA;APLA005863-PA;APLA004850-PA MetaCyc: PWY-5738 GDP-6-deoxy-D-talose biosynthesis 2 APLA009143-PA;APLA009161-PA Reactome: R-HSA-9609690 HCMV Early Events 36 APLA000427-PA;APLA010596-PA;APLA002551-PA;APLA002878-PA;APLA013359-PA;APLA011986-PA;APLA000426-PA;APLA014998-PA;APLA004383-PA;APLA006060-PA;APLA015416-PA;APLA010197-PA;APLA012596-PA;APLA001290-PA;APLA010198-PA;APLA015031-PA;APLA003482-PA;APLA013357-PA;APLA009708-PA;APLA005565-PA;APLA014850-PA;APLA005231-PA;APLA005336-PA;APLA012338-PA;APLA007858-PA;APLA014048-PA;APLA010196-PA;APLA008446-PA;APLA004137-PA;APLA015058-PA;APLA009417-PA;APLA011447-PA;APLA001953-PA;APLA000162-PA;APLA010643-PA;APLA002444-PA Reactome: R-HSA-163210 Formation of ATP by chemiosmotic coupling 17 APLA004746-PA;APLA005788-PA;APLA003430-PA;APLA011684-PA;APLA014283-PA;APLA015229-PA;APLA007966-PA;APLA000012-PA;APLA015214-PA;APLA013770-PA;APLA012585-PA;APLA003759-PA;APLA004097-PA;APLA004886-PA;APLA004095-PA;APLA004887-PA;APLA009120-PA Reactome: R-HSA-73980 RNA Polymerase III Transcription Termination 14 APLA003046-PA;APLA008215-PA;APLA000743-PA;APLA012594-PA;APLA005113-PA;APLA009711-PA;APLA005484-PA;APLA014037-PA;APLA013703-PA;APLA001551-PA;APLA005703-PA;APLA003647-PA;APLA002219-PA;APLA000113-PA KEGG: 00500+2.4.1.11 Starch and sucrose metabolism 1 APLA000677-PA MetaCyc: PWY-2261 Ascorbate glutathione cycle 1 APLA014577-PA Reactome: R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 2 APLA014272-PA;APLA002288-PA MetaCyc: PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II 4 APLA010998-PA;APLA000788-PA;APLA002378-PA;APLA014015-PA Reactome: R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 1 APLA011927-PA Reactome: R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 1 APLA009193-PA KEGG: 00680+3.1.3.11 Methane metabolism 1 APLA009512-PA MetaCyc: PWY-6824 Justicidin B biosynthesis 1 APLA014196-PA MetaCyc: PWY-6703 Preq0 biosynthesis 1 APLA006918-PA Reactome: R-HSA-1474244 Extracellular matrix organization 2 APLA003082-PA;APLA003085-PA Reactome: R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 31 APLA004447-PA;APLA006660-PA;APLA004448-PA;APLA011837-PA;APLA008186-PA;APLA009433-PA;APLA005449-PA;APLA010312-PA;APLA000204-PA;APLA004459-PA;APLA001514-PA;APLA015064-PA;APLA008152-PA;APLA007823-PA;APLA006663-PA;APLA005955-PA;APLA012607-PA;APLA008337-PA;APLA002451-PA;APLA006662-PA;APLA007887-PA;APLA010275-PA;APLA010662-PA;APLA013198-PA;APLA003680-PA;APLA008653-PA;APLA008217-PA;APLA012579-PA;APLA006664-PA;APLA008274-PA;APLA003383-PA MetaCyc: PWY-7839 Lacto-series glycosphingolipids biosynthesis 1 APLA012402-PA KEGG: 00230+2.4.2.1 Purine metabolism 2 APLA013738-PA;APLA000262-PA MetaCyc: PWY-8001 Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis 3 APLA004294-PA;APLA004285-PA;APLA004293-PA Reactome: R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 5 APLA001633-PA;APLA012421-PA;APLA002140-PA;APLA003480-PA;APLA006305-PA MetaCyc: PWY-7222 Guanosine deoxyribonucleotides de novo biosynthesis II 5 APLA002995-PA;APLA009372-PA;APLA001267-PA;APLA012574-PA;APLA000359-PA KEGG: 00600+3.5.1.23 Sphingolipid metabolism 1 APLA004099-PA MetaCyc: PWY-6642 (R)-cysteate degradation 2 APLA012145-PA;APLA012983-PA Reactome: R-HSA-5579007 Defective ACY1 causes encephalopathy 1 APLA003981-PA MetaCyc: PWY-7524 Mevalonate pathway III (archaea) 2 APLA007166-PA;APLA012425-PA KEGG: 00290+2.6.1.42 Valine, leucine and isoleucine biosynthesis 1 APLA006327-PA MetaCyc: PWY-5132 Lupulone and humulone biosynthesis 2 APLA008135-PA;APLA006387-PA Reactome: R-HSA-5619061 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) 1 APLA005798-PA KEGG: 00270+2.6.1.5 Cysteine and methionine metabolism 1 APLA013125-PA MetaCyc: PWY-5079 L-phenylalanine degradation III 1 APLA001970-PA Reactome: R-HSA-5578998 Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) 1 APLA014013-PA KEGG: 00230+2.7.1.40 Purine metabolism 1 APLA015268-PA Reactome: R-HSA-376176 Signaling by ROBO receptors 1 APLA002455-PA KEGG: 00970+6.1.1.15 Aminoacyl-tRNA biosynthesis 2 APLA008833-PA;APLA005033-PA MetaCyc: PWY-7559 Glutathione degradation (DUG pathway 3 APLA004285-PA;APLA004293-PA;APLA004294-PA Reactome: R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 36 APLA004368-PA;APLA010387-PA;APLA000884-PA;APLA001596-PA;APLA014520-PA;APLA009703-PA;APLA006016-PA;APLA014272-PA;APLA001691-PA;APLA003842-PA;APLA008283-PA;APLA003279-PA;APLA002288-PA;APLA003046-PA;APLA008788-PA;APLA015384-PA;APLA000879-PA;APLA014921-PA;APLA005000-PA;APLA001194-PA;APLA002832-PA;APLA014037-PA;APLA010986-PA;APLA013151-PA;APLA001624-PA;APLA014545-PA;APLA003196-PA;APLA014841-PA;APLA005141-PA;APLA003193-PA;APLA002790-PA;APLA000743-PA;APLA001551-PA;APLA001459-PA;APLA013703-PA;APLA013813-PA MetaCyc: PWY-5744 Glyoxylate assimilation 7 APLA014966-PA;APLA008850-PA;APLA002692-PA;APLA010822-PA;APLA010823-PA;APLA013496-PA;APLA013219-PA KEGG: 00670+2.1.2.9 One carbon pool by folate 3 APLA008023-PA;APLA005811-PA;APLA005950-PA KEGG: 00240+4.1.1.23 Pyrimidine metabolism 1 APLA004501-PA KEGG: 00630+6.4.1.3 Glyoxylate and dicarboxylate metabolism 1 APLA007201-PA MetaCyc: PWY-7254 TCA cycle VII (acetate-producers) 7 APLA015489-PA;APLA003089-PA;APLA003262-PA;APLA006254-PA;APLA013330-PA;APLA000357-PA;APLA001137-PA MetaCyc: PWY-5963 Thio-molybdenum cofactor biosynthesis 1 APLA001255-PA Reactome: R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 2 APLA008490-PA;APLA008489-PA Reactome: R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 6 APLA001457-PA;APLA011446-PA;APLA001691-PA;APLA005348-PA;APLA014841-PA;APLA013902-PA KEGG: 00020+6.4.1.1 Citrate cycle (TCA cycle) 1 APLA013385-PA KEGG: 00515+2.4.1.109 Mannose type O-glycan biosynthesis 6 APLA008830-PA;APLA008605-PA;APLA010474-PA;APLA007195-PA;APLA007255-PA;APLA012979-PA Reactome: R-HSA-167590 Nef Mediated CD4 Down-regulation 4 APLA000368-PA;APLA008115-PA;APLA001793-PA;APLA003280-PA Reactome: R-HSA-170968 Frs2-mediated activation 1 APLA002140-PA KEGG: 00670+2.1.2.1 One carbon pool by folate 1 APLA000499-PA Reactome: R-HSA-110331 Cleavage of the damaged purine 1 APLA010076-PA Reactome: R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 7 APLA002544-PA;APLA006201-PA;APLA006200-PA;APLA013496-PA;APLA006203-PA;APLA013385-PA;APLA007201-PA Reactome: R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 2 APLA002288-PA;APLA014272-PA Reactome: R-HSA-1368082 RORA activates gene expression 6 APLA008152-PA;APLA011837-PA;APLA015064-PA;APLA003680-PA;APLA004459-PA;APLA001514-PA KEGG: 00230+3.6.1.6 Purine metabolism 1 APLA012076-PA Reactome: R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 1 APLA010287-PA KEGG: 00562+3.1.3.25 Inositol phosphate metabolism 2 APLA002096-PA;APLA008242-PA MetaCyc: PWY-7337 10-cis-heptadecenoyl-CoA degradation (yeast) 2 APLA013190-PA;APLA003250-PA Reactome: R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 3 APLA001633-PA;APLA003480-PA;APLA010601-PA KEGG: 00521+5.5.1.4 Streptomycin biosynthesis 1 APLA012083-PA KEGG: 00430+2.3.2.2 Taurine and hypotaurine metabolism 3 APLA004294-PA;APLA004285-PA;APLA004293-PA MetaCyc: PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 1 APLA003180-PA Reactome: R-HSA-381042 PERK regulates gene expression 1 APLA014029-PA KEGG: 00480+3.4.11.1 Glutathione metabolism 4 APLA011984-PA;APLA009518-PA;APLA009884-PA;APLA011983-PA Reactome: R-HSA-2022928 HS-GAG biosynthesis 8 APLA011087-PA;APLA003246-PA;APLA011086-PA;APLA011894-PA;APLA011893-PA;APLA013952-PA;APLA011085-PA;APLA007558-PA Reactome: R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 4 APLA014546-PA;APLA000454-PA;APLA002288-PA;APLA014272-PA Reactome: R-HSA-446199 Synthesis of Dolichyl-phosphate 4 APLA004859-PA;APLA000371-PA;APLA000828-PA;APLA014320-PA KEGG: 00770+2.6.1.42 Pantothenate and CoA biosynthesis 1 APLA006327-PA KEGG: 00360+4.2.1.17 Phenylalanine metabolism 4 APLA006174-PA;APLA006178-PA;APLA014896-PA;APLA000468-PA MetaCyc: PWY-5971 Palmitate biosynthesis II (bacteria and plant cytoplasm) 3 APLA002072-PA;APLA002545-PA;APLA007857-PA Reactome: R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 1 APLA009848-PA Reactome: R-HSA-5689877 Josephin domain DUBs 7 APLA014272-PA;APLA002825-PA;APLA002288-PA;APLA008790-PA;APLA000551-PA;APLA013918-PA;APLA010507-PA Reactome: R-HSA-191859 snRNP Assembly 27 APLA002005-PA;APLA002444-PA;APLA002937-PA;APLA003482-PA;APLA003799-PA;APLA007133-PA;APLA010643-PA;APLA002938-PA;APLA015058-PA;APLA006060-PA;APLA004137-PA;APLA001209-PA;APLA011447-PA;APLA001290-PA;APLA000426-PA;APLA005336-PA;APLA005231-PA;APLA010637-PA;APLA011986-PA;APLA003999-PA;APLA009708-PA;APLA008152-PA;APLA000427-PA;APLA015233-PA;APLA005894-PA;APLA005565-PA;APLA002878-PA KEGG: 00480+1.1.1.42 Glutathione metabolism 1 APLA001137-PA MetaCyc: PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 2 APLA012508-PA;APLA002192-PA Reactome: R-HSA-5654712 FRS-mediated FGFR4 signaling 1 APLA005551-PA MetaCyc: PWY-7395 D-galactosamine and N-acetyl-D-galactosamine degradation 1 APLA000217-PA Reactome: R-HSA-194840 Rho GTPase cycle 46 APLA012118-PA;APLA010856-PA;APLA005337-PA;APLA005581-PA;APLA013950-PA;APLA005319-PA;APLA009177-PA;APLA011850-PA;APLA004200-PA;APLA007155-PA;APLA014155-PA;APLA011378-PA;APLA008159-PA;APLA014624-PA;APLA001320-PA;APLA009984-PA;APLA005249-PA;APLA014160-PA;APLA003270-PA;APLA013187-PA;APLA003679-PA;APLA015026-PA;APLA014439-PA;APLA001198-PA;APLA011848-PA;APLA007407-PA;APLA002954-PA;APLA009180-PA;APLA003736-PA;APLA000866-PA;APLA004630-PA;APLA004850-PA;APLA000447-PA;APLA001653-PA;APLA000593-PA;APLA014622-PA;APLA003127-PA;APLA012117-PA;APLA006672-PA;APLA000824-PA;APLA001471-PA;APLA008637-PA;APLA012421-PA;APLA006684-PA;APLA014330-PA;APLA012909-PA Reactome: R-HSA-167162 RNA Polymerase II HIV Promoter Escape 28 APLA013703-PA;APLA014037-PA;APLA010986-PA;APLA012883-PA;APLA001551-PA;APLA000879-PA;APLA003046-PA;APLA005246-PA;APLA000743-PA;APLA008290-PA;APLA005145-PA;APLA015000-PA;APLA003842-PA;APLA003279-PA;APLA008108-PA;APLA014520-PA;APLA001596-PA;APLA009703-PA;APLA014999-PA;APLA006899-PA;APLA001478-PA;APLA001624-PA;APLA000670-PA;APLA008112-PA;APLA014646-PA;APLA012150-PA;APLA007145-PA;APLA011482-PA KEGG: 00720+1.5.1.20 Carbon fixation pathways in prokaryotes 1 APLA003860-PA Reactome: R-HSA-5617833 Cilium Assembly 19 APLA015031-PA;APLA006927-PA;APLA001953-PA;APLA010198-PA;APLA009417-PA;APLA010197-PA;APLA004383-PA;APLA015416-PA;APLA008446-PA;APLA010196-PA;APLA014048-PA;APLA012338-PA;APLA007858-PA;APLA014998-PA;APLA014850-PA;APLA013359-PA;APLA013357-PA;APLA002551-PA;APLA010596-PA MetaCyc: PWY-5486 Pyruvate fermentation to ethanol II 1 APLA001970-PA Reactome: R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 4 APLA009226-PA;APLA009847-PA;APLA007710-PA;APLA005893-PA Reactome: R-HSA-9646399 Aggrephagy 24 APLA008446-PA;APLA010196-PA;APLA014048-PA;APLA007858-PA;APLA012338-PA;APLA014998-PA;APLA014850-PA;APLA008790-PA;APLA013359-PA;APLA014272-PA;APLA013357-PA;APLA002551-PA;APLA010596-PA;APLA007447-PA;APLA002288-PA;APLA015031-PA;APLA001953-PA;APLA010198-PA;APLA009417-PA;APLA010197-PA;APLA004383-PA;APLA013918-PA;APLA011952-PA;APLA015416-PA Reactome: R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated 3 APLA001633-PA;APLA003480-PA;APLA010601-PA MetaCyc: PWY-46 Putrescine biosynthesis III 1 APLA010889-PA Reactome: R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1 APLA002079-PA MetaCyc: PWY-7779 Methyl tert-butyl ether degradation 4 APLA000468-PA;APLA006178-PA;APLA014896-PA;APLA006174-PA KEGG: 05235+3.1.3.16 PD-L1 expression and PD-1 checkpoint pathway in cancer 33 APLA000289-PA;APLA002510-PA;APLA009999-PA;APLA012551-PA;APLA012635-PA;APLA000004-PA;APLA005060-PA;APLA011704-PA;APLA002857-PA;APLA011993-PA;APLA003839-PA;APLA014831-PA;APLA000291-PA;APLA002573-PA;APLA009304-PA;APLA007805-PA;APLA009814-PA;APLA003696-PA;APLA005888-PA;APLA012854-PA;APLA012875-PA;APLA000398-PA;APLA000158-PA;APLA000967-PA;APLA009552-PA;APLA013081-PA;APLA002665-PA;APLA005349-PA;APLA001974-PA;APLA004000-PA;APLA001038-PA;APLA013338-PA;APLA014024-PA Reactome: R-HSA-418890 Role of second messengers in netrin-1 signaling 4 APLA005667-PA;APLA005665-PA;APLA003605-PA;APLA006570-PA Reactome: R-HSA-3899300 SUMOylation of transcription cofactors 5 APLA001514-PA;APLA011837-PA;APLA007447-PA;APLA011952-PA;APLA010286-PA Reactome: R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 87 APLA000605-PA;APLA006618-PA;APLA005706-PA;APLA014384-PA;APLA003014-PA;APLA005697-PA;APLA002938-PA;APLA012910-PA;APLA013210-PA;APLA006659-PA;APLA010469-PA;APLA014046-PA;APLA013308-PA;APLA000210-PA;APLA000130-PA;APLA002625-PA;APLA007905-PA;APLA007375-PA;APLA005454-PA;APLA003509-PA;APLA011333-PA;APLA002288-PA;APLA014042-PA;APLA008015-PA;APLA002114-PA;APLA008182-PA;APLA014444-PA;APLA012510-PA;APLA012986-PA;APLA014343-PA;APLA014272-PA;APLA002004-PA;APLA014985-PA;APLA005154-PA;APLA010040-PA;APLA002294-PA;APLA008225-PA;APLA012226-PA;APLA015388-PA;APLA011066-PA;APLA003217-PA;APLA001686-PA;APLA012151-PA;APLA013597-PA;APLA000956-PA;APLA005384-PA;APLA010675-PA;APLA003064-PA;APLA012609-PA;APLA009234-PA;APLA014107-PA;APLA007956-PA;APLA009489-PA;APLA012911-PA;APLA001622-PA;APLA006227-PA;APLA009149-PA;APLA006379-PA;APLA007492-PA;APLA008766-PA;APLA011527-PA;APLA013392-PA;APLA010839-PA;APLA008614-PA;APLA009213-PA;APLA005404-PA;APLA010013-PA;APLA008588-PA;APLA002937-PA;APLA004075-PA;APLA000488-PA;APLA012185-PA;APLA009753-PA;APLA004544-PA;APLA003770-PA;APLA000682-PA;APLA010605-PA;APLA005265-PA;APLA002086-PA;APLA013595-PA;APLA003102-PA;APLA006079-PA;APLA003269-PA;APLA010999-PA;APLA000142-PA;APLA013231-PA;APLA009495-PA MetaCyc: PWY-5844 Menaquinol-9 biosynthesis 1 APLA015235-PA Reactome: R-HSA-1483148 Synthesis of PG 4 APLA011460-PA;APLA004542-PA;APLA006163-PA;APLA007623-PA KEGG: 00983+2.5.1.18 Drug metabolism - other enzymes 1 APLA014577-PA Reactome: R-HSA-354192 Integrin signaling 1 APLA013745-PA KEGG: 00230+1.17.4.1 Purine metabolism 2 APLA001267-PA;APLA012574-PA KEGG: 00270+2.1.1.37 Cysteine and methionine metabolism 3 APLA001231-PA;APLA005906-PA;APLA004194-PA Reactome: R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 28 APLA011482-PA;APLA007145-PA;APLA012150-PA;APLA014646-PA;APLA008112-PA;APLA000670-PA;APLA001478-PA;APLA006899-PA;APLA001624-PA;APLA014999-PA;APLA009703-PA;APLA001596-PA;APLA014520-PA;APLA008108-PA;APLA003279-PA;APLA008290-PA;APLA015000-PA;APLA005145-PA;APLA003842-PA;APLA000743-PA;APLA005246-PA;APLA003046-PA;APLA000879-PA;APLA001551-PA;APLA012883-PA;APLA014037-PA;APLA010986-PA;APLA013703-PA KEGG: 00020+1.2.4.2 Citrate cycle (TCA cycle) 3 APLA007913-PA;APLA011349-PA;APLA003091-PA MetaCyc: PWY-7416 Phospholipid remodeling (phosphatidylcholine, yeast) 7 APLA005749-PA;APLA005748-PA;APLA001975-PA;APLA004469-PA;APLA009078-PA;APLA009079-PA;APLA012384-PA Reactome: R-HSA-174490 Membrane binding and targetting of GAG proteins 6 APLA002288-PA;APLA005195-PA;APLA003608-PA;APLA003018-PA;APLA014272-PA;APLA008872-PA KEGG: 00910+1.4.1.14 Nitrogen metabolism 1 APLA002704-PA MetaCyc: PWY-7536 2-amino-3-hydroxycyclopent-2-enone biosynthesis 1 APLA010645-PA MetaCyc: PWY-4661 1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza) 3 APLA014683-PA;APLA012083-PA;APLA003180-PA MetaCyc: PWY-7900 Glycogen biosynthesis III (from alpha-maltose 1-phosphate) 4 APLA007993-PA;APLA001295-PA;APLA001296-PA;APLA003655-PA Reactome: R-HSA-375276 Peptide ligand-binding receptors 6 APLA015481-PA;APLA008313-PA;APLA001129-PA;APLA004098-PA;APLA005274-PA;APLA000938-PA MetaCyc: PWY-6619 Adenine and adenosine salvage VI 3 APLA001446-PA;APLA001538-PA;APLA009855-PA Reactome: R-HSA-69473 G2/M DNA damage checkpoint 19 APLA005141-PA;APLA014443-PA;APLA003193-PA;APLA003151-PA;APLA009424-PA;APLA014377-PA;APLA014545-PA;APLA000884-PA;APLA002383-PA;APLA003353-PA;APLA007822-PA;APLA001459-PA;APLA002832-PA;APLA005000-PA;APLA014958-PA;APLA012406-PA;APLA001541-PA;APLA009662-PA;APLA006643-PA Reactome: R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 3 APLA015287-PA;APLA014398-PA;APLA014973-PA Reactome: R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 4 APLA002545-PA;APLA002072-PA;APLA002547-PA;APLA007857-PA Reactome: R-HSA-3238698 WNT ligand biogenesis and trafficking 16 APLA004752-PA;APLA009726-PA;APLA009730-PA;APLA010595-PA;APLA009723-PA;APLA001589-PA;APLA011586-PA;APLA007530-PA;APLA004909-PA;APLA009724-PA;APLA009727-PA;APLA015399-PA;APLA009728-PA;APLA009729-PA;APLA014378-PA;APLA007531-PA Reactome: R-HSA-70635 Urea cycle 1 APLA010889-PA KEGG: 00603+3.2.1.22 Glycosphingolipid biosynthesis - globo and isoglobo series 5 APLA007164-PA;APLA007466-PA;APLA007468-PA;APLA007467-PA;APLA007538-PA Reactome: R-HSA-1296061 HCN channels 1 APLA001742-PA Reactome: R-HSA-212676 Dopamine Neurotransmitter Release Cycle 4 APLA002653-PA;APLA007949-PA;APLA009144-PA;APLA002651-PA Reactome: R-HSA-70688 Proline catabolism 3 APLA011969-PA;APLA006252-PA;APLA002148-PA Reactome: R-HSA-176187 Activation of ATR in response to replication stress 29 APLA001388-PA;APLA014006-PA;APLA001541-PA;APLA001663-PA;APLA013902-PA;APLA014775-PA;APLA002832-PA;APLA010598-PA;APLA001459-PA;APLA008067-PA;APLA005000-PA;APLA009423-PA;APLA008611-PA;APLA001307-PA;APLA011532-PA;APLA008613-PA;APLA001682-PA;APLA010172-PA;APLA007715-PA;APLA005141-PA;APLA013214-PA;APLA014433-PA;APLA002390-PA;APLA003193-PA;APLA014377-PA;APLA003151-PA;APLA006933-PA;APLA014545-PA;APLA000884-PA KEGG: 00010+4.1.2.13 Glycolysis / Gluconeogenesis 2 APLA000565-PA;APLA000619-PA Reactome: R-HSA-5362517 Signaling by Retinoic Acid 5 APLA005998-PA;APLA003939-PA;APLA012569-PA;APLA001487-PA;APLA014770-PA KEGG: 00230+3.5.4.6 Purine metabolism 1 APLA014477-PA Reactome: R-HSA-156711 Polo-like kinase mediated events 3 APLA005348-PA;APLA001457-PA;APLA011446-PA Reactome: R-HSA-1170546 Prolactin receptor signaling 2 APLA003843-PA;APLA006607-PA Reactome: R-HSA-6807505 RNA polymerase II transcribes snRNA genes 37 APLA008684-PA;APLA003253-PA;APLA008108-PA;APLA000547-PA;APLA007145-PA;APLA002642-PA;APLA014253-PA;APLA008112-PA;APLA006899-PA;APLA012489-PA;APLA001551-PA;APLA013703-PA;APLA009125-PA;APLA015000-PA;APLA012562-PA;APLA000743-PA;APLA013306-PA;APLA002938-PA;APLA001456-PA;APLA000320-PA;APLA014999-PA;APLA014520-PA;APLA010852-PA;APLA007500-PA;APLA002857-PA;APLA007698-PA;APLA009719-PA;APLA012561-PA;APLA012563-PA;APLA012883-PA;APLA014037-PA;APLA008290-PA;APLA003842-PA;APLA007931-PA;APLA007912-PA;APLA002937-PA;APLA003046-PA Reactome: R-HSA-9635644 Inhibition of membrane repair 1 APLA000454-PA KEGG: 00330+1.5.5.2 Arginine and proline metabolism 3 APLA002148-PA;APLA006252-PA;APLA011969-PA Reactome: R-HSA-5656169 Termination of translesion DNA synthesis 18 APLA013151-PA;APLA000537-PA;APLA006016-PA;APLA005141-PA;APLA002790-PA;APLA001691-PA;APLA014272-PA;APLA003193-PA;APLA010387-PA;APLA014545-PA;APLA014841-PA;APLA000884-PA;APLA002288-PA;APLA008283-PA;APLA002832-PA;APLA001459-PA;APLA005000-PA;APLA002022-PA KEGG: 00010+1.1.1.27 Glycolysis / Gluconeogenesis 2 APLA000736-PA;APLA000737-PA Reactome: R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 18 APLA010196-PA;APLA014048-PA;APLA008446-PA;APLA014998-PA;APLA007858-PA;APLA012338-PA;APLA014850-PA;APLA013359-PA;APLA002551-PA;APLA010596-PA;APLA013357-PA;APLA015031-PA;APLA001953-PA;APLA010198-PA;APLA009417-PA;APLA010197-PA;APLA015416-PA;APLA004383-PA MetaCyc: PWY-6700 Queuosine biosynthesis I (de novo) 2 APLA009733-PA;APLA008300-PA Reactome: R-HSA-5607764 CLEC7A (Dectin-1) signaling 36 APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA006943-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA005756-PA;APLA010347-PA;APLA015028-PA;APLA013223-PA;APLA002934-PA;APLA012977-PA;APLA006607-PA;APLA001313-PA;APLA014272-PA;APLA002428-PA;APLA002873-PA;APLA014016-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA008987-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA011713-PA;APLA013745-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA010460-PA;APLA004504-PA Reactome: R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation 1 APLA003058-PA MetaCyc: PWY-6367 D-myo-inositol-5-phosphate metabolism 6 APLA006554-PA;APLA008422-PA;APLA006557-PA;APLA014442-PA;APLA012536-PA;APLA003808-PA MetaCyc: PWY-8012 Mupirocin biosynthesis 3 APLA002545-PA;APLA002072-PA;APLA007857-PA MetaCyc: PWY-8047 Bryostatin biosynthesis 3 APLA007857-PA;APLA002072-PA;APLA002545-PA Reactome: R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 16 APLA005565-PA;APLA002878-PA;APLA000427-PA;APLA009708-PA;APLA011986-PA;APLA000426-PA;APLA005336-PA;APLA005231-PA;APLA011447-PA;APLA001290-PA;APLA004137-PA;APLA006060-PA;APLA015058-PA;APLA003482-PA;APLA010643-PA;APLA002444-PA Reactome: R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 11 APLA007872-PA;APLA003055-PA;APLA014272-PA;APLA014003-PA;APLA005017-PA;APLA002288-PA;APLA002140-PA;APLA011005-PA;APLA000940-PA;APLA000806-PA;APLA005264-PA MetaCyc: PWY-6614 Tetrahydrofolate biosynthesis 1 APLA012570-PA Reactome: R-HSA-351202 Metabolism of polyamines 3 APLA000590-PA;APLA001210-PA;APLA003859-PA Reactome: R-HSA-156902 Peptide chain elongation 71 APLA009149-PA;APLA006379-PA;APLA007492-PA;APLA008766-PA;APLA006227-PA;APLA001622-PA;APLA012911-PA;APLA014107-PA;APLA009234-PA;APLA007956-PA;APLA003064-PA;APLA012609-PA;APLA000956-PA;APLA005384-PA;APLA012151-PA;APLA001686-PA;APLA011066-PA;APLA015388-PA;APLA003217-PA;APLA009495-PA;APLA013231-PA;APLA010999-PA;APLA003269-PA;APLA002086-PA;APLA005265-PA;APLA006079-PA;APLA003102-PA;APLA003770-PA;APLA010605-PA;APLA000682-PA;APLA004544-PA;APLA012185-PA;APLA009753-PA;APLA008588-PA;APLA010013-PA;APLA000488-PA;APLA004075-PA;APLA009213-PA;APLA005404-PA;APLA013392-PA;APLA010839-PA;APLA008614-PA;APLA014046-PA;APLA013308-PA;APLA010469-PA;APLA012910-PA;APLA013210-PA;APLA003014-PA;APLA005697-PA;APLA006618-PA;APLA000605-PA;APLA014384-PA;APLA005706-PA;APLA008225-PA;APLA012226-PA;APLA002294-PA;APLA010040-PA;APLA014985-PA;APLA012986-PA;APLA014343-PA;APLA014272-PA;APLA002114-PA;APLA014444-PA;APLA011333-PA;APLA002288-PA;APLA005454-PA;APLA003509-PA;APLA000130-PA;APLA000210-PA;APLA002625-PA;APLA007375-PA Reactome: R-HSA-426117 Cation-coupled Chloride cotransporters 7 APLA002420-PA;APLA001165-PA;APLA010000-PA;APLA001163-PA;APLA001160-PA;APLA004375-PA;APLA005259-PA MetaCyc: PWY-7717 3-hydroxy-4-methyl-anthranilate biosynthesis I 2 APLA005085-PA;APLA001933-PA Reactome: R-HSA-5673001 RAF/MAP kinase cascade 11 APLA010640-PA;APLA003259-PA;APLA002140-PA;APLA011027-PA;APLA006305-PA;APLA010641-PA;APLA001292-PA;APLA007030-PA;APLA002988-PA;APLA005551-PA;APLA010639-PA MetaCyc: PWY-6906 Chitin derivatives degradation 4 APLA002378-PA;APLA000788-PA;APLA010998-PA;APLA000217-PA KEGG: 00740+3.1.3.2 Riboflavin metabolism 1 APLA000700-PA Reactome: R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 21 APLA014999-PA;APLA009703-PA;APLA014520-PA;APLA001596-PA;APLA010731-PA;APLA008108-PA;APLA000547-PA;APLA008112-PA;APLA001624-PA;APLA006899-PA;APLA000879-PA;APLA012981-PA;APLA001551-PA;APLA010986-PA;APLA014037-PA;APLA013703-PA;APLA003279-PA;APLA015000-PA;APLA003842-PA;APLA000743-PA;APLA003046-PA Reactome: R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 18 APLA010643-PA;APLA003482-PA;APLA002444-PA;APLA001290-PA;APLA011447-PA;APLA004137-PA;APLA006060-PA;APLA015058-PA;APLA008660-PA;APLA011986-PA;APLA005336-PA;APLA000426-PA;APLA005231-PA;APLA002878-PA;APLA005565-PA;APLA014679-PA;APLA000427-PA;APLA009708-PA MetaCyc: PWY-621 Sucrose degradation III (sucrose invertase) 1 APLA014015-PA KEGG: 00790+2.8.1.9 Folate biosynthesis 1 APLA001255-PA Reactome: R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 1 APLA005798-PA MetaCyc: PWY-6672 Cis-genanyl-coa degradation 2 APLA006387-PA;APLA008135-PA MetaCyc: PWY-6174 Mevalonate pathway II (archaea) 2 APLA007166-PA;APLA012425-PA Reactome: R-HSA-426486 Small interfering RNA (siRNA) biogenesis 8 APLA013702-PA;APLA010009-PA;APLA012199-PA;APLA013701-PA;APLA014130-PA;APLA014452-PA;APLA014621-PA;APLA003047-PA MetaCyc: PWY-6627 Salinosporamide A biosynthesis 2 APLA000262-PA;APLA013738-PA KEGG: 00051+1.1.1.271 Fructose and mannose metabolism 2 APLA014427-PA;APLA005576-PA KEGG: 00564+2.3.1.51 Glycerophospholipid metabolism 5 APLA012686-PA;APLA014471-PA;APLA004147-PA;APLA000543-PA;APLA008027-PA MetaCyc: PWY-6281 L-selenocysteine biosynthesis II (archaea and eukaryotes) 4 APLA014978-PA;APLA014778-PA;APLA009224-PA;APLA010075-PA Reactome: R-HSA-1614558 Degradation of cysteine and homocysteine 5 APLA012476-PA;APLA004739-PA;APLA007672-PA;APLA014103-PA;APLA011318-PA Reactome: R-HSA-9636383 Prevention of phagosomal-lysosomal fusion 3 APLA000454-PA;APLA014272-PA;APLA002288-PA KEGG: 00960+2.6.1.1 Tropane, piperidine and pyridine alkaloid biosynthesis 2 APLA012145-PA;APLA012983-PA KEGG: 00052+3.5.1.25 Galactose metabolism 1 APLA000217-PA KEGG: 00270+2.6.1.42 Cysteine and methionine metabolism 1 APLA006327-PA Reactome: R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 13 APLA009187-PA;APLA013309-PA;APLA015454-PA;APLA008704-PA;APLA011260-PA;APLA000209-PA;APLA010851-PA;APLA001003-PA;APLA004532-PA;APLA012675-PA;APLA001105-PA;APLA004611-PA;APLA009230-PA MetaCyc: PWY-6317 D-galactose degradation I (Leloir pathway) 5 APLA001518-PA;APLA014848-PA;APLA001443-PA;APLA012066-PA;APLA015199-PA KEGG: 00520+5.3.1.9 Amino sugar and nucleotide sugar metabolism 1 APLA014015-PA Reactome: R-HSA-5358493 Synthesis of diphthamide-EEF2 4 APLA010096-PA;APLA009467-PA;APLA012901-PA;APLA005402-PA Reactome: R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 14 APLA009230-PA;APLA004611-PA;APLA001105-PA;APLA012675-PA;APLA001404-PA;APLA004532-PA;APLA012902-PA;APLA000209-PA;APLA012906-PA;APLA011260-PA;APLA006367-PA;APLA000043-PA;APLA013309-PA;APLA009187-PA Reactome: R-HSA-5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) 1 APLA008825-PA KEGG: 00564+3.1.4.4 Glycerophospholipid metabolism 1 APLA011460-PA MetaCyc: PWYG-321 4 APLA007857-PA;APLA007201-PA;APLA002545-PA;APLA002072-PA KEGG: 00230+3.1.3.5 Purine metabolism 1 APLA002282-PA Reactome: R-HSA-9616222 Transcriptional regulation of granulopoiesis 2 APLA008489-PA;APLA008490-PA MetaCyc: PWY-5491 Diethylphosphate degradation 11 APLA004280-PA;APLA004522-PA;APLA004282-PA;APLA007911-PA;APLA013467-PA;APLA008563-PA;APLA005796-PA;APLA007909-PA;APLA008562-PA;APLA007910-PA;APLA007908-PA MetaCyc: PWY-5659 GDP-mannose biosynthesis 3 APLA014015-PA;APLA004325-PA;APLA009743-PA Reactome: R-HSA-72086 mRNA Capping 23 APLA000547-PA;APLA006899-PA;APLA001624-PA;APLA008112-PA;APLA001596-PA;APLA014520-PA;APLA010731-PA;APLA009703-PA;APLA014999-PA;APLA008108-PA;APLA000743-PA;APLA015000-PA;APLA003842-PA;APLA003279-PA;APLA003046-PA;APLA002938-PA;APLA002937-PA;APLA001551-PA;APLA012981-PA;APLA000879-PA;APLA013703-PA;APLA010986-PA;APLA014037-PA Reactome: R-HSA-2206296 MPS II - Hunter syndrome 1 APLA008323-PA KEGG: 04150+2.7.11.24 mTOR signaling pathway 5 APLA005723-PA;APLA005606-PA;APLA004432-PA;APLA002139-PA;APLA002140-PA Reactome: R-HSA-5419276 Mitochondrial translation termination 49 APLA008421-PA;APLA005695-PA;APLA011305-PA;APLA006947-PA;APLA003598-PA;APLA001022-PA;APLA015036-PA;APLA010331-PA;APLA009248-PA;APLA011020-PA;APLA000197-PA;APLA000426-PA;APLA015082-PA;APLA009119-PA;APLA012294-PA;APLA004314-PA;APLA002753-PA;APLA001936-PA;APLA007494-PA;APLA011712-PA;APLA014334-PA;APLA012546-PA;APLA014309-PA;APLA004449-PA;APLA013155-PA;APLA011778-PA;APLA004983-PA;APLA013883-PA;APLA013787-PA;APLA000316-PA;APLA011113-PA;APLA005078-PA;APLA008576-PA;APLA013466-PA;APLA002494-PA;APLA014874-PA;APLA000120-PA;APLA011220-PA;APLA008154-PA;APLA002636-PA;APLA006681-PA;APLA002854-PA;APLA005357-PA;APLA000812-PA;APLA003061-PA;APLA002581-PA;APLA012699-PA;APLA002686-PA;APLA008443-PA Reactome: R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 10 APLA013151-PA;APLA012406-PA;APLA014545-PA;APLA014841-PA;APLA003508-PA;APLA005141-PA;APLA001691-PA;APLA005929-PA;APLA003193-PA;APLA002832-PA Reactome: R-HSA-8949215 Mitochondrial calcium ion transport 3 APLA002881-PA;APLA004463-PA;APLA002880-PA KEGG: 00362+4.2.1.17+1.1.1.35 Benzoate degradation 4 APLA006178-PA;APLA014896-PA;APLA006174-PA;APLA000468-PA Reactome: R-HSA-429947 Deadenylation of mRNA 8 APLA000633-PA;APLA013196-PA;APLA006673-PA;APLA006367-PA;APLA010173-PA;APLA000749-PA;APLA014833-PA;APLA005787-PA MetaCyc: PWY-5675 Nitrate reduction V (assimilatory) 1 APLA000323-PA Reactome: R-HSA-163359 Glucagon signaling in metabolic regulation 7 APLA013400-PA;APLA005245-PA;APLA014278-PA;APLA007416-PA;APLA007417-PA;APLA003039-PA;APLA003037-PA Reactome: R-HSA-2028269 Signaling by Hippo 2 APLA003517-PA;APLA008224-PA MetaCyc: PWY-7725 Arachidonate biosynthesis V (8-detaturase, mammals) 14 APLA010067-PA;APLA010063-PA;APLA008114-PA;APLA000863-PA;APLA010062-PA;APLA010064-PA;APLA010068-PA;APLA009871-PA;APLA000862-PA;APLA015433-PA;APLA010065-PA;APLA010066-PA;APLA002710-PA;APLA005258-PA Reactome: R-HSA-399719 Trafficking of AMPA receptors 2 APLA002988-PA;APLA007030-PA MetaCyc: PWY-3661-1 Glycine betaine degradation II (mammalian) 1 APLA000499-PA Reactome: R-HSA-167172 Transcription of the HIV genome 28 APLA001624-PA;APLA006899-PA;APLA001478-PA;APLA000670-PA;APLA008112-PA;APLA014646-PA;APLA012150-PA;APLA007145-PA;APLA011482-PA;APLA008108-PA;APLA001596-PA;APLA014520-PA;APLA009703-PA;APLA014999-PA;APLA003046-PA;APLA005246-PA;APLA000743-PA;APLA003842-PA;APLA008290-PA;APLA015000-PA;APLA005145-PA;APLA003279-PA;APLA013703-PA;APLA010986-PA;APLA014037-PA;APLA012883-PA;APLA001551-PA;APLA000879-PA Reactome: R-HSA-2173788 Downregulation of TGF-beta receptor signaling 9 APLA005888-PA;APLA007805-PA;APLA014272-PA;APLA003839-PA;APLA014679-PA;APLA002559-PA;APLA012551-PA;APLA012828-PA;APLA002288-PA KEGG: 00520+3.2.1.52 Amino sugar and nucleotide sugar metabolism 6 APLA003010-PA;APLA010555-PA;APLA001187-PA;APLA012599-PA;APLA006026-PA;APLA002044-PA Reactome: R-HSA-9657050 Defective OGG1 Localization 1 APLA010076-PA Reactome: R-HSA-917937 Iron uptake and transport 3 APLA014272-PA;APLA002288-PA;APLA006607-PA MetaCyc: PWY-7177 UTP and CTP dephosphorylation II 1 APLA010349-PA Reactome: R-HSA-3108214 SUMOylation of DNA damage response and repair proteins 27 APLA002444-PA;APLA006748-PA;APLA010643-PA;APLA003482-PA;APLA001290-PA;APLA011447-PA;APLA002832-PA;APLA015058-PA;APLA014958-PA;APLA004137-PA;APLA006060-PA;APLA000830-PA;APLA004738-PA;APLA011923-PA;APLA005231-PA;APLA005336-PA;APLA000426-PA;APLA004572-PA;APLA001661-PA;APLA011986-PA;APLA005141-PA;APLA009424-PA;APLA002878-PA;APLA005565-PA;APLA009708-PA;APLA014545-PA;APLA000427-PA KEGG: 00270+4.1.1.50 Cysteine and methionine metabolism 1 APLA001210-PA Reactome: R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 75 APLA002086-PA;APLA005265-PA;APLA006079-PA;APLA003102-PA;APLA003770-PA;APLA010605-PA;APLA000682-PA;APLA009495-PA;APLA013231-PA;APLA010999-PA;APLA003269-PA;APLA005404-PA;APLA009213-PA;APLA010839-PA;APLA013392-PA;APLA008614-PA;APLA004544-PA;APLA009753-PA;APLA012185-PA;APLA010013-PA;APLA008588-PA;APLA002937-PA;APLA000488-PA;APLA004075-PA;APLA014107-PA;APLA009234-PA;APLA007956-PA;APLA009149-PA;APLA011527-PA;APLA007492-PA;APLA006379-PA;APLA008766-PA;APLA006227-PA;APLA001622-PA;APLA012911-PA;APLA012151-PA;APLA001686-PA;APLA011066-PA;APLA015388-PA;APLA003217-PA;APLA003064-PA;APLA012609-PA;APLA005384-PA;APLA000956-PA;APLA014985-PA;APLA014343-PA;APLA012986-PA;APLA012510-PA;APLA014272-PA;APLA008225-PA;APLA012226-PA;APLA010040-PA;APLA002294-PA;APLA005454-PA;APLA003509-PA;APLA000130-PA;APLA000210-PA;APLA002625-PA;APLA007375-PA;APLA002114-PA;APLA014444-PA;APLA002288-PA;APLA011333-PA;APLA010469-PA;APLA014046-PA;APLA013308-PA;APLA005697-PA;APLA003014-PA;APLA006618-PA;APLA000605-PA;APLA014384-PA;APLA005706-PA;APLA012910-PA;APLA013210-PA;APLA002938-PA Reactome: R-HSA-210991 Basigin interactions 1 APLA008825-PA KEGG: 00670+1.5.1.20 One carbon pool by folate 1 APLA003860-PA Reactome: R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 21 APLA001551-PA;APLA013703-PA;APLA014037-PA;APLA015000-PA;APLA003842-PA;APLA000743-PA;APLA009185-PA;APLA014024-PA;APLA001456-PA;APLA005321-PA;APLA003046-PA;APLA014999-PA;APLA003187-PA;APLA014520-PA;APLA011795-PA;APLA008108-PA;APLA003048-PA;APLA000547-PA;APLA006924-PA;APLA006899-PA;APLA008112-PA Reactome: R-HSA-3928662 EPHB-mediated forward signaling 7 APLA004850-PA;APLA012291-PA;APLA000767-PA;APLA010039-PA;APLA015057-PA;APLA008080-PA;APLA003259-PA KEGG: 00480+1.11.1.15 Glutathione metabolism 6 APLA001904-PA;APLA008209-PA;APLA012790-PA;APLA005612-PA;APLA008339-PA;APLA000848-PA MetaCyc: PWY-6807 Xyloglucan degradation II (exoglucanase) 7 APLA005795-PA;APLA013714-PA;APLA001817-PA;APLA001673-PA;APLA004972-PA;APLA008561-PA;APLA004969-PA KEGG: 00750+1.4.3.5 Vitamin B6 metabolism 1 APLA013280-PA Reactome: R-HSA-399997 Acetylcholine regulates insulin secretion 2 APLA007917-PA;APLA006554-PA KEGG: 00250+2.1.3.2 Alanine, aspartate and glutamate metabolism 1 APLA002345-PA KEGG: 00511+3.2.1.45 Other glycan degradation 1 APLA004579-PA KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107 Porphyrin and chlorophyll metabolism 1 APLA003859-PA KEGG: 04070+2.7.7.41 Phosphatidylinositol signaling system 2 APLA002731-PA;APLA003095-PA Reactome: R-HSA-6811438 Intra-Golgi traffic 12 APLA004806-PA;APLA001606-PA;APLA006575-PA;APLA010657-PA;APLA012134-PA;APLA003650-PA;APLA009415-PA;APLA006012-PA;APLA001857-PA;APLA009959-PA;APLA002090-PA;APLA011089-PA KEGG: 00520+5.4.2.10 Amino sugar and nucleotide sugar metabolism 5 APLA015298-PA;APLA011781-PA;APLA005932-PA;APLA002378-PA;APLA011784-PA Reactome: R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 3 APLA015287-PA;APLA014398-PA;APLA014973-PA Reactome: R-HSA-8849473 PTK6 Expression 2 APLA012166-PA;APLA009362-PA KEGG: 00270+3.3.1.1 Cysteine and methionine metabolism 2 APLA006390-PA;APLA012141-PA KEGG: 00254+6.4.1.2 Aflatoxin biosynthesis 1 APLA013496-PA KEGG: 00510+2.7.8.15 N-Glycan biosynthesis 1 APLA002213-PA Reactome: R-HSA-427359 SIRT1 negatively regulates rRNA expression 3 APLA003311-PA;APLA008236-PA;APLA008234-PA KEGG: 00401+2.6.1.5 Novobiocin biosynthesis 1 APLA013125-PA KEGG: 00970+2.1.2.9 Aminoacyl-tRNA biosynthesis 3 APLA005950-PA;APLA005811-PA;APLA008023-PA Reactome: R-HSA-1295596 Spry regulation of FGF signaling 3 APLA014272-PA;APLA002288-PA;APLA002140-PA MetaCyc: PWY-6992 1,5-anhydrofructose degradation 2 APLA004325-PA;APLA014015-PA Reactome: R-HSA-6784531 tRNA processing in the nucleus 31 APLA015058-PA;APLA008660-PA;APLA006060-PA;APLA004137-PA;APLA001199-PA;APLA001290-PA;APLA000369-PA;APLA011447-PA;APLA008768-PA;APLA013252-PA;APLA006970-PA;APLA001197-PA;APLA011587-PA;APLA003252-PA;APLA007137-PA;APLA002444-PA;APLA010643-PA;APLA003482-PA;APLA009708-PA;APLA000315-PA;APLA000427-PA;APLA002878-PA;APLA005565-PA;APLA005231-PA;APLA000426-PA;APLA005336-PA;APLA011986-PA;APLA002055-PA;APLA007127-PA;APLA006854-PA;APLA013653-PA KEGG: 00564+1.1.1.94 Glycerophospholipid metabolism 1 APLA008024-PA Reactome: R-HSA-71384 Ethanol oxidation 5 APLA008907-PA;APLA014154-PA;APLA001970-PA;APLA003644-PA;APLA008135-PA Reactome: R-HSA-1632852 Macroautophagy 26 APLA012152-PA;APLA005545-PA;APLA005357-PA;APLA014264-PA;APLA004875-PA;APLA009758-PA;APLA007498-PA;APLA003527-PA;APLA001089-PA;APLA012874-PA;APLA014094-PA;APLA010301-PA;APLA005829-PA;APLA009150-PA;APLA015495-PA;APLA014601-PA;APLA006750-PA;APLA014194-PA;APLA010535-PA;APLA009658-PA;APLA008732-PA;APLA002692-PA;APLA007496-PA;APLA002543-PA;APLA014835-PA;APLA002002-PA MetaCyc: PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide 3 APLA005472-PA;APLA002118-PA;APLA005473-PA KEGG: 00500+2.4.1.15 Starch and sucrose metabolism 1 APLA002501-PA Reactome: R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 12 APLA008243-PA;APLA011309-PA;APLA008489-PA;APLA012840-PA;APLA004907-PA;APLA008490-PA;APLA009481-PA;APLA014534-PA;APLA003922-PA;APLA010562-PA;APLA014542-PA;APLA006474-PA KEGG: 00450+2.7.7.4 Selenocompound metabolism 1 APLA000768-PA Reactome: R-HSA-162588 Budding and maturation of HIV virion 7 APLA014272-PA;APLA003018-PA;APLA008872-PA;APLA002707-PA;APLA002288-PA;APLA005195-PA;APLA003608-PA MetaCyc: PWY-5484 Glycolysis II (from fructose 6-phosphate) 18 APLA010497-PA;APLA006779-PA;APLA000619-PA;APLA000565-PA;APLA013706-PA;APLA003818-PA;APLA006547-PA;APLA015268-PA;APLA010500-PA;APLA003817-PA;APLA009512-PA;APLA007679-PA;APLA007919-PA;APLA004744-PA;APLA007488-PA;APLA013705-PA;APLA010499-PA;APLA000476-PA Reactome: R-HSA-9645722 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 1 APLA015204-PA Reactome: R-HSA-170660 Adenylate cyclase activating pathway 7 APLA003037-PA;APLA007417-PA;APLA007416-PA;APLA003039-PA;APLA005245-PA;APLA014278-PA;APLA013400-PA Reactome: R-HSA-5689901 Metalloprotease DUBs 5 APLA002288-PA;APLA007822-PA;APLA001399-PA;APLA014272-PA;APLA002383-PA Reactome: R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 3 APLA014272-PA;APLA002288-PA;APLA011103-PA KEGG: 00592+3.1.1.32 alpha-Linolenic acid metabolism 3 APLA008047-PA;APLA002539-PA;APLA012865-PA Reactome: R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 1 APLA014679-PA Reactome: R-HSA-2022857 Keratan sulfate degradation 5 APLA003010-PA;APLA012599-PA;APLA002044-PA;APLA006026-PA;APLA005913-PA Reactome: R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 36 APLA011713-PA;APLA008686-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA004504-PA;APLA010460-PA;APLA008490-PA;APLA008836-PA;APLA000126-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008987-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA002428-PA;APLA014272-PA;APLA002873-PA;APLA001313-PA;APLA014016-PA;APLA001596-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA006943-PA;APLA008489-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA005756-PA;APLA010347-PA MetaCyc: PWY-735 Jasmonic acid biosynthesis 2 APLA013190-PA;APLA003250-PA KEGG: 00680+1.1.1.37 Methane metabolism 3 APLA000684-PA;APLA005378-PA;APLA015456-PA Reactome: R-HSA-5632928 Defective Mismatch Repair Associated With MSH2 2 APLA011608-PA;APLA003508-PA Reactome: R-HSA-74259 Purine catabolism 8 APLA013738-PA;APLA002333-PA;APLA009849-PA;APLA001862-PA;APLA014913-PA;APLA000262-PA;APLA000440-PA;APLA001860-PA MetaCyc: PWY-6643 Coenzyme M biosynthesis II 2 APLA012145-PA;APLA012983-PA Reactome: R-HSA-5579006 Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) 2 APLA011248-PA;APLA011246-PA KEGG: 00720+1.1.1.37 Carbon fixation pathways in prokaryotes 3 APLA015456-PA;APLA005378-PA;APLA000684-PA KEGG: 00310+1.8.1.4 Lysine degradation 1 APLA003939-PA Reactome: R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 10 APLA005017-PA;APLA014003-PA;APLA002288-PA;APLA011005-PA;APLA000940-PA;APLA000806-PA;APLA005264-PA;APLA007872-PA;APLA003055-PA;APLA014272-PA KEGG: 00720+1.5.1.5+3.5.4.9 Carbon fixation pathways in prokaryotes 2 APLA005741-PA;APLA005730-PA Reactome: R-HSA-200425 Carnitine metabolism 2 APLA005624-PA;APLA013496-PA Reactome: R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 2 APLA008490-PA;APLA008489-PA MetaCyc: PWY-5913 Partial TCA cycle (obligate autotrophs) 12 APLA012983-PA;APLA001878-PA;APLA015456-PA;APLA005378-PA;APLA004846-PA;APLA001137-PA;APLA003089-PA;APLA002458-PA;APLA014289-PA;APLA010449-PA;APLA012145-PA;APLA000684-PA KEGG: 00500+2.7.1.1 Starch and sucrose metabolism 2 APLA002389-PA;APLA001397-PA MetaCyc: PWY-6722 Candicidin biosynthesis 4 APLA010822-PA;APLA013496-PA;APLA013219-PA;APLA010823-PA KEGG: 00230+6.3.4.13 Purine metabolism 1 APLA005811-PA KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14 Fatty acid biosynthesis 3 APLA007857-PA;APLA002545-PA;APLA002072-PA Reactome: R-HSA-216083 Integrin cell surface interactions 11 APLA010280-PA;APLA009721-PA;APLA001062-PA;APLA003085-PA;APLA004528-PA;APLA003221-PA;APLA009771-PA;APLA003222-PA;APLA004526-PA;APLA003082-PA;APLA004527-PA Reactome: R-HSA-2980766 Nuclear Envelope Breakdown 1 APLA009431-PA KEGG: 00640+4.2.1.17 Propanoate metabolism 4 APLA006174-PA;APLA006178-PA;APLA014896-PA;APLA000468-PA Reactome: R-HSA-6803157 Antimicrobial peptides 5 APLA013590-PA;APLA009159-PA;APLA000560-PA;APLA013588-PA;APLA010406-PA Reactome: R-HSA-5423646 Aflatoxin activation and detoxification 7 APLA011092-PA;APLA011093-PA;APLA011095-PA;APLA011104-PA;APLA003981-PA;APLA011106-PA;APLA002059-PA Reactome: R-HSA-5654733 Negative regulation of FGFR4 signaling 3 APLA014272-PA;APLA002288-PA;APLA002140-PA KEGG: 00561+2.7.1.107 Glycerolipid metabolism 5 APLA013224-PA;APLA006190-PA;APLA012308-PA;APLA011740-PA;APLA011921-PA Reactome: R-HSA-168276 NS1 Mediated Effects on Host Pathways 19 APLA004186-PA;APLA000426-PA;APLA005231-PA;APLA005336-PA;APLA011986-PA;APLA002878-PA;APLA005565-PA;APLA004371-PA;APLA009708-PA;APLA000427-PA;APLA002444-PA;APLA010643-PA;APLA003482-PA;APLA001290-PA;APLA011447-PA;APLA002485-PA;APLA015058-PA;APLA004137-PA;APLA006060-PA Reactome: R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 9 APLA007945-PA;APLA006113-PA;APLA005011-PA;APLA002288-PA;APLA008497-PA;APLA008509-PA;APLA009966-PA;APLA014272-PA;APLA006117-PA Reactome: R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 35 APLA001290-PA;APLA002297-PA;APLA006060-PA;APLA014338-PA;APLA010675-PA;APLA002938-PA;APLA003482-PA;APLA010315-PA;APLA013645-PA;APLA003898-PA;APLA009518-PA;APLA002878-PA;APLA012186-PA;APLA009489-PA;APLA000427-PA;APLA014667-PA;APLA009973-PA;APLA000426-PA;APLA011986-PA;APLA011447-PA;APLA002298-PA;APLA015058-PA;APLA004276-PA;APLA004137-PA;APLA002937-PA;APLA002444-PA;APLA010643-PA;APLA014042-PA;APLA000465-PA;APLA014430-PA;APLA005565-PA;APLA009708-PA;APLA005336-PA;APLA005063-PA;APLA005231-PA KEGG: 00740+2.7.1.26 Riboflavin metabolism 1 APLA014390-PA Reactome: R-HSA-5678895 Defective CFTR causes cystic fibrosis 40 APLA002873-PA;APLA002428-PA;APLA014272-PA;APLA001313-PA;APLA014016-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA006943-PA;APLA010460-PA;APLA004504-PA;APLA008790-PA;APLA011713-PA;APLA004494-PA;APLA013844-PA;APLA015189-PA;APLA008686-PA;APLA009873-PA;APLA000968-PA;APLA001601-PA;APLA013968-PA;APLA001685-PA;APLA001687-PA;APLA005704-PA;APLA012085-PA;APLA008836-PA;APLA000126-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA000970-PA;APLA008987-PA Reactome: R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 3 APLA003480-PA;APLA010601-PA;APLA001633-PA Reactome: R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels 1 APLA003571-PA Reactome: R-HSA-2408557 Selenocysteine synthesis 72 APLA010040-PA;APLA002294-PA;APLA012226-PA;APLA008225-PA;APLA010075-PA;APLA014272-PA;APLA014343-PA;APLA012986-PA;APLA014985-PA;APLA011333-PA;APLA002288-PA;APLA014444-PA;APLA002114-PA;APLA007375-PA;APLA000130-PA;APLA000210-PA;APLA002625-PA;APLA003509-PA;APLA005454-PA;APLA013308-PA;APLA014046-PA;APLA010469-PA;APLA013210-PA;APLA012910-PA;APLA014384-PA;APLA005706-PA;APLA006618-PA;APLA000605-PA;APLA003014-PA;APLA005697-PA;APLA010999-PA;APLA003269-PA;APLA009495-PA;APLA013231-PA;APLA010605-PA;APLA000682-PA;APLA003770-PA;APLA006079-PA;APLA003102-PA;APLA002086-PA;APLA005265-PA;APLA000488-PA;APLA004075-PA;APLA010013-PA;APLA008588-PA;APLA004544-PA;APLA012185-PA;APLA009753-PA;APLA008614-PA;APLA013392-PA;APLA010839-PA;APLA009213-PA;APLA005404-PA;APLA001622-PA;APLA006227-PA;APLA012911-PA;APLA008766-PA;APLA006379-PA;APLA007492-PA;APLA009149-PA;APLA007956-PA;APLA014107-PA;APLA009234-PA;APLA005384-PA;APLA000956-PA;APLA012609-PA;APLA003064-PA;APLA001686-PA;APLA003217-PA;APLA015388-PA;APLA011066-PA;APLA012151-PA Reactome: R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 14 APLA012691-PA;APLA004044-PA;APLA015383-PA;APLA001617-PA;APLA001977-PA;APLA015178-PA;APLA014312-PA;APLA002840-PA;APLA001611-PA;APLA011440-PA;APLA001819-PA;APLA001229-PA;APLA001547-PA;APLA005297-PA Reactome: R-HSA-983712 Ion channel transport 18 APLA000114-PA;APLA008018-PA;APLA000056-PA;APLA000368-PA;APLA004385-PA;APLA007060-PA;APLA010311-PA;APLA008019-PA;APLA005327-PA;APLA003280-PA;APLA006015-PA;APLA008016-PA;APLA015217-PA;APLA002666-PA;APLA006357-PA;APLA008022-PA;APLA001263-PA;APLA013217-PA KEGG: 00240+3.6.1.6 Pyrimidine metabolism 1 APLA012076-PA Reactome: R-HSA-5339700 TCF7L2 mutants don't bind CTBP 1 APLA011311-PA KEGG: 00510+2.4.1.131 N-Glycan biosynthesis 1 APLA006458-PA Reactome: R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 10 APLA014250-PA;APLA003156-PA;APLA012032-PA;APLA013817-PA;APLA007882-PA;APLA012027-PA;APLA013300-PA;APLA012033-PA;APLA009149-PA;APLA014252-PA Reactome: R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 7 APLA011106-PA;APLA002059-PA;APLA003023-PA;APLA011093-PA;APLA011092-PA;APLA011095-PA;APLA011104-PA MetaCyc: PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 2 APLA005085-PA;APLA001933-PA MetaCyc: PWY-7375 Mrna capping I 2 APLA012981-PA;APLA010731-PA MetaCyc: PWY-5367 Petroselinate biosynthesis 3 APLA007857-PA;APLA002072-PA;APLA002545-PA MetaCyc: PWY-7442 Drosopterin and aurodrosopterin biosynthesis 1 APLA006918-PA MetaCyc: PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I 3 APLA008936-PA;APLA012530-PA;APLA005811-PA Reactome: R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 5 APLA001380-PA;APLA002675-PA;APLA001514-PA;APLA011837-PA;APLA008956-PA MetaCyc: PWY-5895 Menaquinol-13 biosynthesis 1 APLA015235-PA Reactome: R-HSA-4551295 Defective ALG11 causes ALG11-CDG (CDG-1p) 1 APLA006458-PA Reactome: R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 8 APLA003055-PA;APLA007872-PA;APLA005017-PA;APLA014003-PA;APLA000940-PA;APLA000806-PA;APLA005264-PA;APLA011005-PA KEGG: 00380+3.5.1.9 Tryptophan metabolism 1 APLA005085-PA MetaCyc: PWY-6012 Acyl carrier protein metabolism 1 APLA001971-PA Reactome: R-HSA-2206307 MPS IIIA - Sanfilippo syndrome A 1 APLA009742-PA MetaCyc: PWY-5667 CDP-diacylglycerol biosynthesis I 10 APLA008024-PA;APLA012686-PA;APLA000543-PA;APLA008027-PA;APLA004147-PA;APLA014471-PA;APLA002731-PA;APLA002667-PA;APLA009816-PA;APLA003095-PA Reactome: R-HSA-180534 Vpu mediated degradation of CD4 34 APLA014016-PA;APLA006607-PA;APLA001313-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA006943-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA010460-PA;APLA004504-PA;APLA008686-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA011713-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA000126-PA;APLA008836-PA MetaCyc: PWY-1622 Formaldehyde assimilation I (serine pathway) 10 APLA007919-PA;APLA015456-PA;APLA005378-PA;APLA010499-PA;APLA004744-PA;APLA000499-PA;APLA010497-PA;APLA010500-PA;APLA006779-PA;APLA000684-PA MetaCyc: PWY-7385 1,3-propanediol biosynthesis (engineered) 5 APLA014015-PA;APLA013705-PA;APLA000619-PA;APLA000565-PA;APLA013706-PA Reactome: R-HSA-5675482 Regulation of necroptotic cell death 2 APLA014272-PA;APLA002288-PA Reactome: R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 3 APLA007030-PA;APLA002988-PA;APLA003259-PA Reactome: R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 31 APLA011713-PA;APLA015028-PA;APLA013223-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA012977-PA;APLA004504-PA;APLA010460-PA;APLA001313-PA;APLA002873-PA;APLA002428-PA;APLA014016-PA;APLA010995-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA010791-PA;APLA000126-PA;APLA008987-PA;APLA006943-PA;APLA001601-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA005704-PA;APLA005756-PA;APLA013968-PA;APLA010347-PA Reactome: R-HSA-9614399 Regulation of localization of FOXO transcription factors 1 APLA001921-PA KEGG: 00983+2.4.2.10 Drug metabolism - other enzymes 1 APLA004501-PA KEGG: 00460+2.3.2.2 Cyanoamino acid metabolism 3 APLA004293-PA;APLA004285-PA;APLA004294-PA Reactome: R-HSA-70171 Glycolysis 17 APLA010998-PA;APLA015308-PA;APLA007488-PA;APLA014015-PA;APLA000476-PA;APLA013705-PA;APLA015268-PA;APLA001397-PA;APLA003817-PA;APLA007679-PA;APLA007680-PA;APLA000619-PA;APLA003818-PA;APLA000565-PA;APLA013706-PA;APLA006547-PA;APLA002389-PA KEGG: 00500+3.2.1.28 Starch and sucrose metabolism 3 APLA003488-PA;APLA014434-PA;APLA001185-PA KEGG: 00500+3.6.1.9 Starch and sucrose metabolism 2 APLA009005-PA;APLA009849-PA Reactome: R-HSA-8934593 Regulation of RUNX1 Expression and Activity 7 APLA013701-PA;APLA008490-PA;APLA014130-PA;APLA013702-PA;APLA008489-PA;APLA003047-PA;APLA009856-PA Reactome: R-HSA-2586552 Signaling by Leptin 1 APLA003843-PA Reactome: R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 2 APLA009772-PA;APLA002140-PA KEGG: 04070+2.7.8.11 Phosphatidylinositol signaling system 1 APLA010033-PA Reactome: R-HSA-446205 Synthesis of GDP-mannose 4 APLA010018-PA;APLA002501-PA;APLA009743-PA;APLA004325-PA MetaCyc: PWY-5723 Rubisco shunt 8 APLA008988-PA;APLA010497-PA;APLA010500-PA;APLA015268-PA;APLA000025-PA;APLA010499-PA;APLA015453-PA;APLA007919-PA Reactome: R-HSA-163615 PKA activation 10 APLA009113-PA;APLA003348-PA;APLA010182-PA;APLA013400-PA;APLA005245-PA;APLA014278-PA;APLA003039-PA;APLA007417-PA;APLA007416-PA;APLA003037-PA KEGG: 00130+2.1.1.163 Ubiquinone and other terpenoid-quinone biosynthesis 1 APLA015235-PA MetaCyc: PWY-6964 Ammonia assimilation cycle II 1 APLA000323-PA Reactome: R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 41 APLA002873-PA;APLA002428-PA;APLA014272-PA;APLA001313-PA;APLA014016-PA;APLA003055-PA;APLA013223-PA;APLA015028-PA;APLA000940-PA;APLA005264-PA;APLA005017-PA;APLA012977-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA005756-PA;APLA007872-PA;APLA010347-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA006943-PA;APLA014003-PA;APLA004504-PA;APLA010460-PA;APLA011713-PA;APLA011005-PA;APLA000806-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA000126-PA;APLA008836-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA008987-PA MetaCyc: PWY-6282 Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) 3 APLA007857-PA;APLA002072-PA;APLA002545-PA KEGG: 00250+2.4.2.14 Alanine, aspartate and glutamate metabolism 1 APLA008936-PA Reactome: R-HSA-6782315 tRNA modification in the nucleus and cytosol 23 APLA008833-PA;APLA012587-PA;APLA005323-PA;APLA005959-PA;APLA009733-PA;APLA008504-PA;APLA002194-PA;APLA006256-PA;APLA010423-PA;APLA003242-PA;APLA009759-PA;APLA011405-PA;APLA012987-PA;APLA015202-PA;APLA010314-PA;APLA013811-PA;APLA008300-PA;APLA015344-PA;APLA004551-PA;APLA006619-PA;APLA010508-PA;APLA004905-PA;APLA006392-PA Reactome: R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 2 APLA007917-PA;APLA006554-PA MetaCyc: PWY-6963 Ammonia assimilation cycle I 2 APLA000323-PA;APLA002704-PA KEGG: 00561+2.3.1.15 Glycerolipid metabolism 2 APLA009816-PA;APLA002667-PA MetaCyc: PWY-3781 Aerobic respiration I (cytochrome c) 6 APLA006254-PA;APLA015489-PA;APLA003262-PA;APLA000133-PA;APLA000357-PA;APLA013330-PA MetaCyc: PWY-5177 Glutaryl-coa degradation 4 APLA006178-PA;APLA014896-PA;APLA006174-PA;APLA000468-PA MetaCyc: PWY-6134 L-tyrosine biosynthesis IV 1 APLA006614-PA Reactome: R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 1 APLA009848-PA Reactome: R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 2 APLA007580-PA;APLA002364-PA MetaCyc: PWY-2201 Folate transformations I 4 APLA005741-PA;APLA000499-PA;APLA003860-PA;APLA005730-PA MetaCyc: PWY-5082 L-methionine degradation III 1 APLA001970-PA Reactome: R-HSA-5673000 RAF activation 3 APLA007030-PA;APLA003480-PA;APLA001633-PA Reactome: R-HSA-8986944 Transcriptional Regulation by MECP2 5 APLA014130-PA;APLA013701-PA;APLA013702-PA;APLA003047-PA;APLA009856-PA Reactome: R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 23 APLA001833-PA;APLA002135-PA;APLA010643-PA;APLA002883-PA;APLA004639-PA;APLA014307-PA;APLA015058-PA;APLA009660-PA;APLA003480-PA;APLA011986-PA;APLA014772-PA;APLA000426-PA;APLA002859-PA;APLA001683-PA;APLA002909-PA;APLA001351-PA;APLA000427-PA;APLA005242-PA;APLA002856-PA;APLA007552-PA;APLA001633-PA;APLA013547-PA;APLA014679-PA Reactome: R-HSA-3785653 Myoclonic epilepsy of Lafora 2 APLA002288-PA;APLA014272-PA Reactome: R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 3 APLA005348-PA;APLA001457-PA;APLA011446-PA KEGG: 00520+1.1.1.271 Amino sugar and nucleotide sugar metabolism 2 APLA005576-PA;APLA014427-PA MetaCyc: PWY-6638 Sulfolactate degradation III 2 APLA012145-PA;APLA012983-PA KEGG: 05165+2.7.1.153 Human papillomavirus infection 1 APLA002528-PA MetaCyc: PWY-3961 Phosphopantothenate biosynthesis II 1 APLA007948-PA Reactome: R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 32 APLA013223-PA;APLA015028-PA;APLA012977-PA;APLA001313-PA;APLA002873-PA;APLA002428-PA;APLA014016-PA;APLA010995-PA;APLA010791-PA;APLA006943-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA005756-PA;APLA010347-PA;APLA011713-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA010460-PA;APLA004504-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA000126-PA;APLA008987-PA;APLA001662-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA Reactome: R-HSA-6807878 COPI-mediated anterograde transport 44 APLA002090-PA;APLA014536-PA;APLA015031-PA;APLA012813-PA;APLA002639-PA;APLA009772-PA;APLA010197-PA;APLA001292-PA;APLA015416-PA;APLA004383-PA;APLA004453-PA;APLA010198-PA;APLA015241-PA;APLA006575-PA;APLA011027-PA;APLA014998-PA;APLA002551-PA;APLA010596-PA;APLA005501-PA;APLA012134-PA;APLA008532-PA;APLA010657-PA;APLA013359-PA;APLA001953-PA;APLA003210-PA;APLA006070-PA;APLA009415-PA;APLA002355-PA;APLA015228-PA;APLA009417-PA;APLA001857-PA;APLA008436-PA;APLA009959-PA;APLA014850-PA;APLA014048-PA;APLA003650-PA;APLA010196-PA;APLA008446-PA;APLA007858-PA;APLA012338-PA;APLA005427-PA;APLA013357-PA;APLA006345-PA;APLA004806-PA MetaCyc: PWY-5466 Matairesinol biosynthesis 1 APLA014196-PA KEGG: 00230+3.5.4.4 Purine metabolism 3 APLA015153-PA;APLA006726-PA;APLA006728-PA Reactome: R-HSA-3214847 HATs acetylate histones 35 APLA011837-PA;APLA013963-PA;APLA012150-PA;APLA006380-PA;APLA004543-PA;APLA010436-PA;APLA005101-PA;APLA011617-PA;APLA008288-PA;APLA000615-PA;APLA004705-PA;APLA014830-PA;APLA001506-PA;APLA007975-PA;APLA012406-PA;APLA014395-PA;APLA000688-PA;APLA001540-PA;APLA010437-PA;APLA009951-PA;APLA000829-PA;APLA010863-PA;APLA001514-PA;APLA014646-PA;APLA012306-PA;APLA014620-PA;APLA009371-PA;APLA010332-PA;APLA005952-PA;APLA012877-PA;APLA004772-PA;APLA001378-PA;APLA002675-PA;APLA012604-PA;APLA007577-PA Reactome: R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 8 APLA011005-PA;APLA005264-PA;APLA000940-PA;APLA000806-PA;APLA005017-PA;APLA014003-PA;APLA007872-PA;APLA003055-PA Reactome: R-HSA-4641258 Degradation of DVL 33 APLA011713-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA010460-PA;APLA004504-PA;APLA008836-PA;APLA000126-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA008987-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA;APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA014272-PA;APLA002428-PA;APLA002873-PA;APLA001313-PA;APLA014016-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA006943-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA005756-PA;APLA010347-PA Reactome: R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 8 APLA009488-PA;APLA003544-PA;APLA002555-PA;APLA003678-PA;APLA007932-PA;APLA005245-PA;APLA004700-PA;APLA008693-PA Reactome: R-HSA-72689 Formation of a pool of free 40S subunits 83 APLA012609-PA;APLA003064-PA;APLA005384-PA;APLA000956-PA;APLA007319-PA;APLA012151-PA;APLA003217-PA;APLA015388-PA;APLA011066-PA;APLA001686-PA;APLA007492-PA;APLA006379-PA;APLA008766-PA;APLA009149-PA;APLA015197-PA;APLA012911-PA;APLA006227-PA;APLA001622-PA;APLA005196-PA;APLA003286-PA;APLA007956-PA;APLA009234-PA;APLA001987-PA;APLA014107-PA;APLA012185-PA;APLA009753-PA;APLA004544-PA;APLA005999-PA;APLA004075-PA;APLA000488-PA;APLA010013-PA;APLA008588-PA;APLA009213-PA;APLA005404-PA;APLA008614-PA;APLA010839-PA;APLA013392-PA;APLA013231-PA;APLA009495-PA;APLA003269-PA;APLA010999-PA;APLA003102-PA;APLA006079-PA;APLA002086-PA;APLA005265-PA;APLA000050-PA;APLA000682-PA;APLA010605-PA;APLA003770-PA;APLA013210-PA;APLA012910-PA;APLA001093-PA;APLA003014-PA;APLA005697-PA;APLA005706-PA;APLA014384-PA;APLA004503-PA;APLA000605-PA;APLA006618-PA;APLA013308-PA;APLA014046-PA;APLA010469-PA;APLA014444-PA;APLA002114-PA;APLA006586-PA;APLA011333-PA;APLA002288-PA;APLA003509-PA;APLA005476-PA;APLA005454-PA;APLA007375-PA;APLA000210-PA;APLA002625-PA;APLA000130-PA;APLA012226-PA;APLA008225-PA;APLA010040-PA;APLA002294-PA;APLA014985-PA;APLA014272-PA;APLA003093-PA;APLA012986-PA;APLA014343-PA Reactome: R-HSA-1538133 G0 and Early G1 3 APLA001457-PA;APLA011446-PA;APLA005348-PA MetaCyc: PWY-4702 Phytate degradation I 2 APLA002096-PA;APLA008242-PA Reactome: R-HSA-5173105 O-linked glycosylation 5 APLA007157-PA;APLA007256-PA;APLA007255-PA;APLA008830-PA;APLA008829-PA Reactome: R-HSA-5576892 Phase 0 - rapid depolarisation 10 APLA011359-PA;APLA010365-PA;APLA005630-PA;APLA014240-PA;APLA007030-PA;APLA008885-PA;APLA009388-PA;APLA014672-PA;APLA008887-PA;APLA003527-PA MetaCyc: PWY-5080 Very long chain fatty acid biosynthesis I 14 APLA010067-PA;APLA010064-PA;APLA010062-PA;APLA000863-PA;APLA008114-PA;APLA010063-PA;APLA000862-PA;APLA010068-PA;APLA009871-PA;APLA005258-PA;APLA002710-PA;APLA010066-PA;APLA015433-PA;APLA010065-PA MetaCyc: PWY-6352 3-phosphoinositide biosynthesis 2 APLA010033-PA;APLA002528-PA MetaCyc: PWY-7255 Ergothioneine biosynthesis I (bacteria) 4 APLA013161-PA;APLA003096-PA;APLA003098-PA;APLA009670-PA MetaCyc: PWY-7571 Ferrichrome A biosynthesis 1 APLA007166-PA Reactome: R-HSA-426048 Arachidonate production from DAG 2 APLA003272-PA;APLA013069-PA KEGG: 00930+4.2.1.17+1.1.1.35 Caprolactam degradation 4 APLA000468-PA;APLA006174-PA;APLA006178-PA;APLA014896-PA Reactome: R-HSA-3000170 Syndecan interactions 2 APLA013952-PA;APLA009721-PA Reactome: R-HSA-5689880 Ub-specific processing proteases 48 APLA011035-PA;APLA007962-PA;APLA010460-PA;APLA004504-PA;APLA001680-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA008686-PA;APLA011713-PA;APLA013968-PA;APLA005704-PA;APLA001601-PA;APLA004463-PA;APLA008987-PA;APLA013323-PA;APLA008836-PA;APLA000126-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA010419-PA;APLA014016-PA;APLA001168-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA001313-PA;APLA000454-PA;APLA012977-PA;APLA015028-PA;APLA013223-PA;APLA012150-PA;APLA010347-PA;APLA001194-PA;APLA001872-PA;APLA005756-PA;APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA003575-PA;APLA013208-PA;APLA006943-PA;APLA002584-PA;APLA012406-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA Reactome: R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 3 APLA013151-PA;APLA001691-PA;APLA014841-PA KEGG: 04070+3.1.3.25 Phosphatidylinositol signaling system 2 APLA008242-PA;APLA002096-PA MetaCyc: PWY-6372 1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium) 2 APLA012083-PA;APLA014683-PA Reactome: R-HSA-399956 CRMPs in Sema3A signaling 2 APLA009979-PA;APLA006915-PA KEGG: 00625+1.1.1.1 Chloroalkane and chloroalkene degradation 1 APLA001970-PA Reactome: R-HSA-8856828 Clathrin-mediated endocytosis 24 APLA014546-PA;APLA005549-PA;APLA010039-PA;APLA005550-PA;APLA005077-PA;APLA014272-PA;APLA009419-PA;APLA013969-PA;APLA000454-PA;APLA000054-PA;APLA003544-PA;APLA010151-PA;APLA011846-PA;APLA003694-PA;APLA008767-PA;APLA010150-PA;APLA012291-PA;APLA001445-PA;APLA001793-PA;APLA003678-PA;APLA002555-PA;APLA007946-PA;APLA002288-PA;APLA008115-PA Reactome: R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 1 APLA013745-PA Reactome: R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 1 APLA015273-PA Reactome: R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 1 APLA003653-PA Reactome: R-HSA-5696400 Dual Incision in GG-NER 25 APLA002288-PA;APLA014197-PA;APLA008283-PA;APLA003279-PA;APLA012424-PA;APLA010986-PA;APLA002832-PA;APLA001459-PA;APLA000879-PA;APLA005000-PA;APLA000830-PA;APLA013151-PA;APLA001624-PA;APLA006016-PA;APLA006346-PA;APLA005141-PA;APLA001691-PA;APLA002790-PA;APLA014272-PA;APLA003193-PA;APLA014545-PA;APLA010387-PA;APLA009703-PA;APLA014841-PA;APLA000884-PA Reactome: R-HSA-5654726 Negative regulation of FGFR1 signaling 3 APLA002140-PA;APLA002288-PA;APLA014272-PA KEGG: 00510+2.4.1.117 N-Glycan biosynthesis 1 APLA004210-PA Reactome: R-HSA-8963888 Chylomicron assembly 6 APLA003544-PA;APLA009851-PA;APLA004787-PA;APLA003677-PA;APLA002555-PA;APLA003678-PA Reactome: R-HSA-9620244 Long-term potentiation 3 APLA007030-PA;APLA002988-PA;APLA003259-PA MetaCyc: PWY-101 Photosynthesis light reactions 1 APLA015413-PA MetaCyc: PWY-7560 Methylerythritol phosphate pathway II 1 APLA003487-PA Reactome: R-HSA-75953 RNA Polymerase II Transcription Initiation 28 APLA001551-PA;APLA000879-PA;APLA013703-PA;APLA010986-PA;APLA014037-PA;APLA012883-PA;APLA005246-PA;APLA000743-PA;APLA008290-PA;APLA003842-PA;APLA015000-PA;APLA005145-PA;APLA003279-PA;APLA003046-PA;APLA014520-PA;APLA001596-PA;APLA009703-PA;APLA014999-PA;APLA008108-PA;APLA007145-PA;APLA011482-PA;APLA001478-PA;APLA006899-PA;APLA001624-PA;APLA000670-PA;APLA008112-PA;APLA014646-PA;APLA012150-PA Reactome: R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 1 APLA007949-PA MetaCyc: PWY-7746 Mycobacterial sulfolipid biosynthesis 3 APLA002545-PA;APLA002072-PA;APLA007857-PA MetaCyc: PWY-5884 Wax esters biosynthesis I 9 APLA000546-PA;APLA000540-PA;APLA002536-PA;APLA001864-PA;APLA000545-PA;APLA003949-PA;APLA000539-PA;APLA000704-PA;APLA000726-PA KEGG: 00190+7.1.1.8 Oxidative phosphorylation 1 APLA000133-PA Reactome: R-HSA-1614635 Sulfur amino acid metabolism 1 APLA002737-PA MetaCyc: PWY-5138 Fatty acid beta-oxidation IV (unsaturated, even number) 4 APLA000468-PA;APLA006174-PA;APLA006178-PA;APLA014896-PA Reactome: R-HSA-1257604 PIP3 activates AKT signaling 7 APLA013745-PA;APLA011144-PA;APLA012421-PA;APLA014094-PA;APLA006305-PA;APLA005545-PA;APLA010399-PA KEGG: 00230+6.3.4.4 Purine metabolism 1 APLA007847-PA MetaCyc: PWY-7013 (S)-propane-1,2-diol degradation 1 APLA001970-PA KEGG: 00562+3.1.3.36 Inositol phosphate metabolism 2 APLA007407-PA;APLA001445-PA Reactome: R-HSA-167290 Pausing and recovery of HIV elongation 21 APLA014999-PA;APLA011795-PA;APLA014520-PA;APLA003187-PA;APLA008108-PA;APLA003048-PA;APLA000547-PA;APLA006924-PA;APLA008112-PA;APLA006899-PA;APLA001551-PA;APLA014037-PA;APLA013703-PA;APLA015000-PA;APLA003842-PA;APLA000743-PA;APLA009185-PA;APLA014024-PA;APLA003046-PA;APLA005321-PA;APLA001456-PA Reactome: R-HSA-389359 CD28 dependent Vav1 pathway 1 APLA004850-PA Reactome: R-HSA-389977 Post-chaperonin tubulin folding pathway 13 APLA014998-PA;APLA007858-PA;APLA015031-PA;APLA008446-PA;APLA014850-PA;APLA005858-PA;APLA001953-PA;APLA009417-PA;APLA013359-PA;APLA010143-PA;APLA015416-PA;APLA010596-PA;APLA013357-PA Reactome: R-HSA-165054 Rev-mediated nuclear export of HIV RNA 19 APLA000426-PA;APLA005336-PA;APLA005231-PA;APLA011986-PA;APLA009708-PA;APLA000427-PA;APLA014679-PA;APLA013547-PA;APLA002878-PA;APLA005565-PA;APLA002444-PA;APLA010643-PA;APLA003482-PA;APLA015058-PA;APLA008660-PA;APLA006060-PA;APLA004137-PA;APLA001290-PA;APLA011447-PA KEGG: 00620+4.4.1.5 Pyruvate metabolism 1 APLA008758-PA Reactome: R-HSA-5627123 RHO GTPases activate PAKs 2 APLA004850-PA;APLA007946-PA Reactome: R-HSA-5579026 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) 3 APLA007957-PA;APLA002948-PA;APLA008939-PA KEGG: 00620+3.6.1.7 Pyruvate metabolism 2 APLA001557-PA;APLA012643-PA Reactome: R-HSA-419037 NCAM1 interactions 3 APLA009388-PA;APLA003082-PA;APLA003085-PA KEGG: 00240+2.1.1.45 Pyrimidine metabolism 2 APLA008494-PA;APLA009142-PA Reactome: R-HSA-205043 NRIF signals cell death from the nucleus 5 APLA014272-PA;APLA005953-PA;APLA014713-PA;APLA002288-PA;APLA007136-PA MetaCyc: PWY-6369 Inositol diphosphates biosynthesis 2 APLA014683-PA;APLA001574-PA Reactome: R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 3 APLA003259-PA;APLA007030-PA;APLA002988-PA KEGG: 00562+2.7.1.158 Inositol phosphate metabolism 1 APLA014683-PA KEGG: 00600+3.2.1.45 Sphingolipid metabolism 1 APLA004579-PA Reactome: R-HSA-5609978 Defective GALT can cause Galactosemia 1 APLA001518-PA Reactome: R-HSA-2514853 Condensation of Prometaphase Chromosomes 8 APLA003426-PA;APLA012840-PA;APLA009119-PA;APLA014040-PA;APLA005777-PA;APLA005076-PA;APLA014880-PA;APLA000891-PA Reactome: R-HSA-8964041 LDL remodeling 3 APLA003544-PA;APLA003678-PA;APLA002555-PA KEGG: 00030+3.1.1.17 Pentose phosphate pathway 1 APLA005270-PA Reactome: R-HSA-5635838 Activation of SMO 2 APLA009411-PA;APLA012998-PA Reactome: R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 1 APLA009848-PA KEGG: 00592+4.2.1.17 alpha-Linolenic acid metabolism 4 APLA000468-PA;APLA006178-PA;APLA014896-PA;APLA006174-PA Reactome: R-HSA-8964038 LDL clearance 7 APLA012056-PA;APLA008115-PA;APLA001793-PA;APLA002555-PA;APLA003678-PA;APLA003544-PA;APLA004273-PA MetaCyc: PWY-5989 Stearate biosynthesis II (bacteria and plants) 3 APLA002545-PA;APLA002072-PA;APLA007857-PA Reactome: R-HSA-8951664 Neddylation 73 APLA002404-PA;APLA011746-PA;APLA006607-PA;APLA001313-PA;APLA012143-PA;APLA013223-PA;APLA015028-PA;APLA003561-PA;APLA010347-PA;APLA014003-PA;APLA006698-PA;APLA004465-PA;APLA010995-PA;APLA005283-PA;APLA001095-PA;APLA010460-PA;APLA004504-PA;APLA003086-PA;APLA000032-PA;APLA001635-PA;APLA015189-PA;APLA013844-PA;APLA000921-PA;APLA011412-PA;APLA013968-PA;APLA009050-PA;APLA002124-PA;APLA004341-PA;APLA001601-PA;APLA001755-PA;APLA011613-PA;APLA006975-PA;APLA000810-PA;APLA000126-PA;APLA002303-PA;APLA014016-PA;APLA000512-PA;APLA008707-PA;APLA002873-PA;APLA001414-PA;APLA002428-PA;APLA014272-PA;APLA002934-PA;APLA006275-PA;APLA012977-PA;APLA004218-PA;APLA005756-PA;APLA008116-PA;APLA007463-PA;APLA012593-PA;APLA005792-PA;APLA005719-PA;APLA006943-PA;APLA002288-PA;APLA010791-PA;APLA012166-PA;APLA014879-PA;APLA013578-PA;APLA008686-PA;APLA004494-PA;APLA011713-PA;APLA007970-PA;APLA007018-PA;APLA005704-PA;APLA011678-PA;APLA001679-PA;APLA014783-PA;APLA010842-PA;APLA008987-PA;APLA005870-PA;APLA011706-PA;APLA008836-PA;APLA001576-PA MetaCyc: PWY-7035 (9Z)-tricosene biosynthesis 14 APLA010068-PA;APLA009871-PA;APLA000862-PA;APLA010066-PA;APLA010065-PA;APLA015433-PA;APLA005258-PA;APLA002710-PA;APLA010067-PA;APLA000863-PA;APLA010063-PA;APLA008114-PA;APLA010064-PA;APLA010062-PA Reactome: R-HSA-3270619 IRF3-mediated induction of type I IFN 3 APLA007487-PA;APLA007938-PA;APLA012887-PA MetaCyc: PWY-7980 ATP biosynthesis 6 APLA009120-PA;APLA002666-PA;APLA015230-PA;APLA010311-PA;APLA006973-PA;APLA006976-PA Reactome: R-HSA-400253 Circadian Clock 20 APLA003839-PA;APLA007047-PA;APLA011443-PA;APLA004858-PA;APLA002288-PA;APLA003680-PA;APLA007048-PA;APLA005888-PA;APLA003025-PA;APLA015064-PA;APLA008152-PA;APLA000509-PA;APLA006607-PA;APLA012551-PA;APLA007049-PA;APLA007805-PA;APLA014272-PA;APLA011837-PA;APLA004459-PA;APLA001514-PA MetaCyc: PWY-7894 Procollagen hydroxylation and glycosylation 1 APLA011609-PA MetaCyc: PWY-2161 Folate polyglutamylation 3 APLA011535-PA;APLA000499-PA;APLA005730-PA Reactome: R-HSA-203641 NOSTRIN mediated eNOS trafficking 1 APLA008085-PA KEGG: 00290+4.2.1.33 Valine, leucine and isoleucine biosynthesis 1 APLA008464-PA Reactome: R-HSA-2160456 Phenylketonuria 1 APLA006614-PA KEGG: 00565+3.1.1.47 Ether lipid metabolism 1 APLA005818-PA Reactome: R-HSA-5578775 Ion homeostasis 9 APLA004610-PA;APLA007030-PA;APLA003653-PA;APLA010385-PA;APLA012404-PA;APLA004609-PA;APLA004634-PA;APLA002019-PA;APLA012467-PA KEGG: 04151+2.7.11.1 PI3K-Akt signaling pathway 35 APLA008151-PA;APLA011336-PA;APLA012070-PA;APLA013745-PA;APLA011405-PA;APLA003517-PA;APLA011480-PA;APLA005251-PA;APLA009103-PA;APLA015343-PA;APLA008080-PA;APLA001451-PA;APLA003690-PA;APLA001541-PA;APLA014655-PA;APLA010535-PA;APLA010570-PA;APLA006659-PA;APLA002693-PA;APLA009561-PA;APLA003559-PA;APLA014007-PA;APLA012309-PA;APLA014094-PA;APLA000202-PA;APLA009255-PA;APLA002024-PA;APLA014432-PA;APLA004865-PA;APLA006809-PA;APLA005222-PA;APLA005545-PA;APLA005614-PA;APLA005789-PA;APLA006656-PA Reactome: R-HSA-204005 COPII-mediated vesicle transport 20 APLA014769-PA;APLA004548-PA;APLA008949-PA;APLA014128-PA;APLA002153-PA;APLA000721-PA;APLA007154-PA;APLA012581-PA;APLA003966-PA;APLA003650-PA;APLA006597-PA;APLA008529-PA;APLA009772-PA;APLA011721-PA;APLA001000-PA;APLA010885-PA;APLA001524-PA;APLA004329-PA;APLA003964-PA;APLA002423-PA Reactome: R-HSA-9640463 Wax biosynthesis 14 APLA000546-PA;APLA000545-PA;APLA002588-PA;APLA000541-PA;APLA001864-PA;APLA002536-PA;APLA000540-PA;APLA015393-PA;APLA003947-PA;APLA003949-PA;APLA001863-PA;APLA000726-PA;APLA000704-PA;APLA000539-PA KEGG: 00520+2.7.1.6 Amino sugar and nucleotide sugar metabolism 2 APLA014848-PA;APLA001443-PA Reactome: R-HSA-2559585 Oncogene Induced Senescence 4 APLA014272-PA;APLA002288-PA;APLA002140-PA;APLA009856-PA KEGG: 00790+3.4.19.9 Folate biosynthesis 1 APLA007315-PA MetaCyc: PWY-7723 Bacterial bioluminescence 3 APLA007857-PA;APLA002545-PA;APLA002072-PA Reactome: R-HSA-9020702 Interleukin-1 signaling 36 APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA001313-PA;APLA014272-PA;APLA002873-PA;APLA002428-PA;APLA006607-PA;APLA014016-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA006943-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA011713-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA008686-PA;APLA004504-PA;APLA010460-PA;APLA001556-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA008836-PA;APLA010313-PA;APLA000126-PA;APLA008987-PA;APLA001601-PA;APLA013968-PA;APLA005704-PA KEGG: 00640+6.4.1.3 Propanoate metabolism 1 APLA007201-PA KEGG: 00563+2.4.1.198 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 3 APLA012889-PA;APLA012149-PA;APLA009709-PA Reactome: R-HSA-373752 Netrin-1 signaling 1 APLA001559-PA Reactome: R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression 5 APLA012418-PA;APLA004459-PA;APLA003680-PA;APLA015064-PA;APLA008152-PA KEGG: 04070+2.7.1.159 Phosphatidylinositol signaling system 1 APLA003180-PA Reactome: R-HSA-445095 Interaction between L1 and Ankyrins 6 APLA008436-PA;APLA011027-PA;APLA001292-PA;APLA014240-PA;APLA006070-PA;APLA010365-PA MetaCyc: PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 2 APLA008114-PA;APLA005258-PA MetaCyc: PWY-5973 Cis-vaccenate biosynthesis 3 APLA007857-PA;APLA002545-PA;APLA002072-PA Reactome: R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 1 APLA009848-PA KEGG: 00983+2.7.1.48 Drug metabolism - other enzymes 2 APLA002052-PA;APLA008439-PA MetaCyc: PWY-5871 Ubiquinol-9 biosynthesis (eukaryotic) 1 APLA002418-PA KEGG: 00620+6.2.1.1 Pyruvate metabolism 2 APLA008135-PA;APLA006387-PA Reactome: R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 3 APLA010445-PA;APLA002186-PA;APLA005405-PA KEGG: 00010+2.7.1.40 Glycolysis / Gluconeogenesis 1 APLA015268-PA Reactome: R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 2 APLA002288-PA;APLA014272-PA MetaCyc: PWY-6168 Flavin biosynthesis III (fungi) 1 APLA014390-PA Reactome: R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 7 APLA001647-PA;APLA012657-PA;APLA008939-PA;APLA002948-PA;APLA010695-PA;APLA005995-PA;APLA010815-PA Reactome: R-HSA-8983711 OAS antiviral response 1 APLA000109-PA Reactome: R-HSA-4085001 Sialic acid metabolism 3 APLA011533-PA;APLA011592-PA;APLA003237-PA MetaCyc: PWY-7003 Glycerol degradation to butanol 11 APLA007679-PA;APLA003817-PA;APLA010497-PA;APLA015268-PA;APLA010500-PA;APLA000476-PA;APLA010499-PA;APLA006547-PA;APLA007488-PA;APLA003818-PA;APLA007919-PA MetaCyc: PWY-7726 (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase) 8 APLA008114-PA;APLA000468-PA;APLA013190-PA;APLA003250-PA;APLA014896-PA;APLA005258-PA;APLA006174-PA;APLA006178-PA Reactome: R-HSA-211976 Endogenous sterols 3 APLA007957-PA;APLA002948-PA;APLA008939-PA Reactome: R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 1 APLA009848-PA MetaCyc: PWY-5129 Sphingolipid biosynthesis (plants) 2 APLA012402-PA;APLA001711-PA KEGG: 00020+2.3.1.12 Citrate cycle (TCA cycle) 1 APLA014770-PA MetaCyc: PWY-8041 Ultra-long-chain fatty acid biosynthesis 14 APLA002710-PA;APLA005258-PA;APLA015433-PA;APLA010065-PA;APLA010066-PA;APLA000862-PA;APLA009871-PA;APLA010068-PA;APLA010062-PA;APLA010064-PA;APLA008114-PA;APLA010063-PA;APLA000863-PA;APLA010067-PA Reactome: R-HSA-170670 Adenylate cyclase inhibitory pathway 7 APLA007416-PA;APLA007417-PA;APLA003039-PA;APLA003037-PA;APLA013400-PA;APLA014278-PA;APLA005245-PA Reactome: R-HSA-937039 IRAK1 recruits IKK complex 3 APLA014272-PA;APLA002288-PA;APLA001556-PA Reactome: R-HSA-68952 DNA replication initiation 7 APLA008612-PA;APLA006690-PA;APLA007371-PA;APLA008283-PA;APLA014513-PA;APLA006016-PA;APLA008659-PA MetaCyc: PWY-7456 Beta-(1,4)-mannan degradation 2 APLA004325-PA;APLA009743-PA KEGG: 00280+1.8.1.4 Valine, leucine and isoleucine degradation 1 APLA003939-PA KEGG: 00970+6.1.1.11 Aminoacyl-tRNA biosynthesis 3 APLA009224-PA;APLA010075-PA;APLA014978-PA Reactome: R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 1 APLA010287-PA Reactome: R-HSA-1650814 Collagen biosynthesis and modifying enzymes 4 APLA003082-PA;APLA004965-PA;APLA003085-PA;APLA011609-PA MetaCyc: PWY-7574 Propanoyl-coa degradation II 2 APLA013190-PA;APLA003250-PA KEGG: 00010+2.3.1.12 Glycolysis / Gluconeogenesis 1 APLA014770-PA MetaCyc: PWY-5497 Purine nucleobases degradation II (anaerobic) 4 APLA000499-PA;APLA005741-PA;APLA002333-PA;APLA005730-PA Reactome: R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 11 APLA004532-PA;APLA009230-PA;APLA004611-PA;APLA001105-PA;APLA001404-PA;APLA012675-PA;APLA004868-PA;APLA013309-PA;APLA009187-PA;APLA000209-PA;APLA011260-PA MetaCyc: PWY-7573 GDP-mycosamine biosynthesis 2 APLA009161-PA;APLA009143-PA KEGG: 00790+6.3.2.17 Folate biosynthesis 1 APLA011535-PA MetaCyc: PWY-7922 Protein O-mannosylation II (mammals, core M1 and core M2) 7 APLA007255-PA;APLA012979-PA;APLA013212-PA;APLA008605-PA;APLA008830-PA;APLA010474-PA;APLA007195-PA Reactome: R-HSA-2682334 EPH-Ephrin signaling 3 APLA001668-PA;APLA005626-PA;APLA009421-PA Reactome: R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 14 APLA004923-PA;APLA004323-PA;APLA015241-PA;APLA002301-PA;APLA015228-PA;APLA008995-PA;APLA008326-PA;APLA014355-PA;APLA002551-PA;APLA012969-PA;APLA014791-PA;APLA003210-PA;APLA012079-PA;APLA014036-PA Reactome: R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 2 APLA001451-PA;APLA002140-PA KEGG: 00860+6.1.1.17 Porphyrin and chlorophyll metabolism 2 APLA011745-PA;APLA008833-PA KEGG: 00270+6.3.2.2 Cysteine and methionine metabolism 4 APLA003096-PA;APLA013161-PA;APLA009670-PA;APLA003098-PA KEGG: 00030+2.7.1.15 Pentose phosphate pathway 2 APLA005083-PA;APLA005084-PA Reactome: R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 3 APLA002288-PA;APLA004432-PA;APLA014272-PA Reactome: R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 75 APLA012609-PA;APLA011732-PA;APLA003064-PA;APLA005384-PA;APLA000956-PA;APLA012151-PA;APLA001686-PA;APLA011066-PA;APLA015388-PA;APLA003217-PA;APLA006379-PA;APLA008766-PA;APLA007492-PA;APLA009149-PA;APLA006227-PA;APLA001622-PA;APLA012911-PA;APLA007956-PA;APLA014107-PA;APLA009234-PA;APLA004544-PA;APLA009753-PA;APLA012185-PA;APLA004075-PA;APLA000488-PA;APLA010013-PA;APLA008588-PA;APLA009213-PA;APLA005404-PA;APLA008614-PA;APLA010839-PA;APLA013392-PA;APLA009495-PA;APLA013231-PA;APLA010999-PA;APLA003269-PA;APLA006079-PA;APLA003102-PA;APLA002086-PA;APLA005265-PA;APLA010605-PA;APLA000682-PA;APLA012906-PA;APLA003770-PA;APLA013210-PA;APLA012910-PA;APLA014029-PA;APLA003014-PA;APLA005697-PA;APLA014384-PA;APLA005706-PA;APLA006618-PA;APLA000605-PA;APLA013308-PA;APLA014046-PA;APLA010469-PA;APLA014444-PA;APLA002114-PA;APLA002288-PA;APLA011333-PA;APLA003509-PA;APLA005454-PA;APLA007375-PA;APLA000130-PA;APLA000210-PA;APLA002625-PA;APLA012226-PA;APLA012902-PA;APLA008225-PA;APLA010040-PA;APLA002294-PA;APLA014985-PA;APLA014272-PA;APLA014343-PA;APLA012986-PA Reactome: R-HSA-6811555 PI5P Regulates TP53 Acetylation 1 APLA000777-PA MetaCyc: PWY-6596 Adenosine nucleotides degradation I 4 APLA003519-PA;APLA002333-PA;APLA002282-PA;APLA014477-PA MetaCyc: PWY-7654 (8E,10E)-dodeca-8,10-dienol biosynthesis 4 APLA000468-PA;APLA014896-PA;APLA006178-PA;APLA006174-PA KEGG: 00785+2.8.1.8 Lipoic acid metabolism 2 APLA015266-PA;APLA003168-PA KEGG: 00760+6.3.5.1 Nicotinate and nicotinamide metabolism 1 APLA002192-PA Reactome: R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis 8 APLA011087-PA;APLA011086-PA;APLA008128-PA;APLA011894-PA;APLA011893-PA;APLA013952-PA;APLA011085-PA;APLA005358-PA MetaCyc: PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis 6 APLA006557-PA;APLA014442-PA;APLA003808-PA;APLA012536-PA;APLA006554-PA;APLA010033-PA Reactome: R-HSA-1296072 Voltage gated Potassium channels 14 APLA000303-PA;APLA011123-PA;APLA000345-PA;APLA011765-PA;APLA005398-PA;APLA000337-PA;APLA011767-PA;APLA007635-PA;APLA000344-PA;APLA000335-PA;APLA006450-PA;APLA003571-PA;APLA007636-PA;APLA005397-PA MetaCyc: PWY-6123 Inosine-5'-phosphate biosynthesis I 3 APLA008244-PA;APLA007491-PA;APLA008935-PA MetaCyc: PWY-7036 Very long chain fatty acid biosynthesis II 14 APLA010067-PA;APLA000863-PA;APLA010063-PA;APLA008114-PA;APLA010064-PA;APLA010062-PA;APLA010068-PA;APLA009871-PA;APLA000862-PA;APLA010066-PA;APLA015433-PA;APLA010065-PA;APLA005258-PA;APLA002710-PA MetaCyc: PWY-6834 Spermidine biosynthesis III 1 APLA001210-PA KEGG: 05163+2.7.1.153 Human cytomegalovirus infection 1 APLA002528-PA KEGG: 00051+4.2.1.47 Fructose and mannose metabolism 2 APLA009143-PA;APLA009161-PA MetaCyc: PWY-6611 Adenine and adenosine salvage V 5 APLA015153-PA;APLA006728-PA;APLA000262-PA;APLA013738-PA;APLA006726-PA MetaCyc: PWY-5057 L-valine degradation II 2 APLA006327-PA;APLA001970-PA MetaCyc: PWY-2221 Entner-Doudoroff pathway III (semi-phosphorylative) 6 APLA010500-PA;APLA010497-PA;APLA015268-PA;APLA007919-PA;APLA005270-PA;APLA010499-PA MetaCyc: PWY-3841 Folate transformations II (plants) 7 APLA005730-PA;APLA012570-PA;APLA003860-PA;APLA008494-PA;APLA009142-PA;APLA000499-PA;APLA005741-PA MetaCyc: PWY-7783 Plasmalogen degradation 7 APLA012384-PA;APLA004469-PA;APLA009078-PA;APLA009079-PA;APLA001975-PA;APLA005748-PA;APLA005749-PA KEGG: 00230+3.6.1.66 Purine metabolism 1 APLA009849-PA Reactome: R-HSA-114608 Platelet degranulation 2 APLA007118-PA;APLA007117-PA MetaCyc: PWY-6527 Stachyose degradation 9 APLA003021-PA;APLA007468-PA;APLA007538-PA;APLA007467-PA;APLA014848-PA;APLA007164-PA;APLA007466-PA;APLA001443-PA;APLA001518-PA Reactome: R-HSA-165158 Activation of AKT2 1 APLA013745-PA KEGG: 00643+1.13.11.5 Styrene degradation 1 APLA015390-PA Reactome: R-HSA-9614657 FOXO-mediated transcription of cell death genes 3 APLA001514-PA;APLA011837-PA;APLA000043-PA KEGG: 00240+4.2.1.70 Pyrimidine metabolism 1 APLA004816-PA Reactome: R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 2 APLA012736-PA;APLA001292-PA KEGG: 00380+1.11.1.6 Tryptophan metabolism 14 APLA004183-PA;APLA004582-PA;APLA009588-PA;APLA015327-PA;APLA004175-PA;APLA004174-PA;APLA004171-PA;APLA004172-PA;APLA006339-PA;APLA004182-PA;APLA004173-PA;APLA006341-PA;APLA004588-PA;APLA004184-PA Reactome: R-HSA-4793954 Defective MOGS causes MOGS-CDG (CDG-2b) 1 APLA002968-PA MetaCyc: PWY-5686 UMP biosynthesis I 3 APLA004501-PA;APLA008944-PA;APLA002345-PA Reactome: R-HSA-5610783 Degradation of GLI2 by the proteasome 35 APLA013968-PA;APLA005704-PA;APLA001601-PA;APLA008987-PA;APLA000126-PA;APLA008836-PA;APLA006975-PA;APLA000810-PA;APLA011706-PA;APLA004504-PA;APLA010460-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA008686-PA;APLA011713-PA;APLA010347-PA;APLA005756-PA;APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA006943-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA014016-PA;APLA002428-PA;APLA002873-PA;APLA014272-PA;APLA001313-PA;APLA006607-PA;APLA012977-PA;APLA011623-PA;APLA015028-PA;APLA013223-PA KEGG: 00130+4.1.1.90 Ubiquinone and other terpenoid-quinone biosynthesis 2 APLA003042-PA;APLA003040-PA KEGG: 00531+3.2.1.23 Glycosaminoglycan degradation 5 APLA004969-PA;APLA001673-PA;APLA004972-PA;APLA001817-PA;APLA005795-PA Reactome: R-HSA-70263 Gluconeogenesis 16 APLA015308-PA;APLA007488-PA;APLA014015-PA;APLA005378-PA;APLA000476-PA;APLA013385-PA;APLA003817-PA;APLA009512-PA;APLA007679-PA;APLA007680-PA;APLA000619-PA;APLA003818-PA;APLA000565-PA;APLA013213-PA;APLA006547-PA;APLA000684-PA Reactome: R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 1 APLA001380-PA Reactome: R-HSA-3000171 Non-integrin membrane-ECM interactions 10 APLA003024-PA;APLA003082-PA;APLA003731-PA;APLA000730-PA;APLA004087-PA;APLA011073-PA;APLA003085-PA;APLA007157-PA;APLA003026-PA;APLA004085-PA Reactome: R-HSA-5362798 Release of Hh-Np from the secreting cell 2 APLA009411-PA;APLA007945-PA KEGG: 00720+6.4.1.2 Carbon fixation pathways in prokaryotes 1 APLA013496-PA Reactome: R-HSA-156842 Eukaryotic Translation Elongation 5 APLA013660-PA;APLA014284-PA;APLA003546-PA;APLA012401-PA;APLA004217-PA KEGG: 00240+3.5.2.3 Pyrimidine metabolism 1 APLA002345-PA Reactome: R-HSA-419771 Opsins 4 APLA010783-PA;APLA007372-PA;APLA004063-PA;APLA014581-PA MetaCyc: PWY-6823 Molybdenum cofactor biosynthesis 3 APLA008006-PA;APLA009260-PA;APLA008007-PA MetaCyc: PWY-6019 Pseudouridine degradation 1 APLA004816-PA Reactome: R-HSA-112409 RAF-independent MAPK1/3 activation 2 APLA001038-PA;APLA002140-PA KEGG: 00627+3.6.1.7 Aminobenzoate degradation 2 APLA001557-PA;APLA012643-PA MetaCyc: PWY-5188 Tetrapyrrole biosynthesis I (from glutamate) 5 APLA002965-PA;APLA008833-PA;APLA002668-PA;APLA008273-PA;APLA011745-PA Reactome: R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 6 APLA011087-PA;APLA011086-PA;APLA011085-PA;APLA011894-PA;APLA013952-PA;APLA011893-PA MetaCyc: PWY-6587 Pyruvate fermentation to ethanol III 1 APLA001970-PA KEGG: 00400+1.14.16.1 Phenylalanine, tyrosine and tryptophan biosynthesis 1 APLA006614-PA KEGG: 00680+3.1.3.3 Methane metabolism 1 APLA014671-PA KEGG: 00620+2.3.1.12 Pyruvate metabolism 1 APLA014770-PA KEGG: 00330+1.5.1.2 Arginine and proline metabolism 2 APLA011286-PA;APLA008941-PA Reactome: R-HSA-977443 GABA receptor activation 3 APLA014865-PA;APLA003750-PA;APLA012797-PA Reactome: R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 6 APLA011894-PA;APLA011085-PA;APLA013952-PA;APLA011893-PA;APLA011086-PA;APLA011087-PA Reactome: R-HSA-8874211 CREB3 factors activate genes 2 APLA005305-PA;APLA005245-PA MetaCyc: PWY-7288 Fatty acid beta-oxidation VII (yeast peroxisome) 2 APLA013190-PA;APLA003250-PA KEGG: 00760+2.3.1.286 Nicotinate and nicotinamide metabolism 7 APLA008834-PA;APLA009114-PA;APLA014358-PA;APLA014639-PA;APLA013924-PA;APLA013082-PA;APLA004101-PA KEGG: 00970+6.1.1.3 Aminoacyl-tRNA biosynthesis 6 APLA001570-PA;APLA001572-PA;APLA009666-PA;APLA014017-PA;APLA005482-PA;APLA007118-PA Reactome: R-HSA-72731 Recycling of eIF2:GDP 3 APLA014029-PA;APLA001946-PA;APLA011701-PA KEGG: 04150+2.7.11.1 mTOR signaling pathway 35 APLA005545-PA;APLA005222-PA;APLA006809-PA;APLA004865-PA;APLA014432-PA;APLA002024-PA;APLA009255-PA;APLA000202-PA;APLA006656-PA;APLA005789-PA;APLA005614-PA;APLA003690-PA;APLA001451-PA;APLA008080-PA;APLA015343-PA;APLA009103-PA;APLA005251-PA;APLA011480-PA;APLA003517-PA;APLA013745-PA;APLA011405-PA;APLA011336-PA;APLA012070-PA;APLA008151-PA;APLA014094-PA;APLA012309-PA;APLA003559-PA;APLA014007-PA;APLA009561-PA;APLA002693-PA;APLA006659-PA;APLA010535-PA;APLA010570-PA;APLA014655-PA;APLA001541-PA KEGG: 00710+4.1.2.13 Carbon fixation in photosynthetic organisms 2 APLA000619-PA;APLA000565-PA Reactome: R-HSA-4419969 Depolymerisation of the Nuclear Lamina 3 APLA009431-PA;APLA003381-PA;APLA001595-PA MetaCyc: PWY-5104 L-isoleucine biosynthesis IV 1 APLA006327-PA KEGG: 00740+3.6.1.9 Riboflavin metabolism 2 APLA009005-PA;APLA009849-PA Reactome: R-HSA-139915 Activation of PUMA and translocation to mitochondria 1 APLA014258-PA KEGG: 00270+6.3.2.3 Cysteine and methionine metabolism 2 APLA011248-PA;APLA011246-PA KEGG: 00500+2.4.1.25 Starch and sucrose metabolism 2 APLA004011-PA;APLA004009-PA Reactome: R-HSA-3371511 HSF1 activation 5 APLA014545-PA;APLA008790-PA;APLA005141-PA;APLA003193-PA;APLA002832-PA MetaCyc: PWY-7204 Pyridoxal 5'-phosphate salvage II (plants) 3 APLA013280-PA;APLA012135-PA;APLA007551-PA MetaCyc: PWY-6944 Androstenedione degradation 4 APLA014896-PA;APLA006178-PA;APLA006174-PA;APLA000468-PA MetaCyc: PWY-6549 L-glutamine biosynthesis III 2 APLA001137-PA;APLA000323-PA KEGG: 00620+3.1.2.6 Pyruvate metabolism 2 APLA004537-PA;APLA004539-PA Reactome: R-HSA-3000471 Scavenging by Class B Receptors 3 APLA003678-PA;APLA002555-PA;APLA003544-PA Reactome: R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 10 APLA001921-PA;APLA007498-PA;APLA011144-PA;APLA004140-PA;APLA005545-PA;APLA014094-PA;APLA009255-PA;APLA007496-PA;APLA013745-PA;APLA010399-PA MetaCyc: PWY-5994 Palmitate biosynthesis (animals and fungi, cytoplasm) 3 APLA002545-PA;APLA002072-PA;APLA007857-PA Reactome: R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 2 APLA008490-PA;APLA008489-PA MetaCyc: PWY-7767 L-leucine degradation IV (Stickland reaction) 1 APLA006327-PA Reactome: R-HSA-1221632 Meiotic synapsis 1 APLA001541-PA KEGG: 00380+4.2.1.17+1.1.1.35 Tryptophan metabolism 4 APLA006174-PA;APLA014896-PA;APLA006178-PA;APLA000468-PA Reactome: R-HSA-418555 G alpha (s) signalling events 7 APLA003037-PA;APLA007417-PA;APLA007416-PA;APLA003039-PA;APLA005245-PA;APLA014278-PA;APLA013400-PA Reactome: R-HSA-5221030 TET1,2,3 and TDG demethylate DNA 2 APLA006221-PA;APLA006748-PA Reactome: R-HSA-1169091 Activation of NF-kappaB in B cells 35 APLA011713-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA008686-PA;APLA010460-PA;APLA004504-PA;APLA008836-PA;APLA000126-PA;APLA006975-PA;APLA011706-PA;APLA000810-PA;APLA008987-PA;APLA001601-PA;APLA013968-PA;APLA005704-PA;APLA013223-PA;APLA015028-PA;APLA012977-PA;APLA002934-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA001313-PA;APLA006607-PA;APLA014016-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA006943-PA;APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA Reactome: R-HSA-6799198 Complex I biogenesis 42 APLA005367-PA;APLA008155-PA;APLA012074-PA;APLA015229-PA;APLA001852-PA;APLA012188-PA;APLA005031-PA;APLA011710-PA;APLA004506-PA;APLA010703-PA;APLA005412-PA;APLA010532-PA;APLA005591-PA;APLA005010-PA;APLA015237-PA;APLA010752-PA;APLA012616-PA;APLA007915-PA;APLA012855-PA;APLA004808-PA;APLA009245-PA;APLA001658-PA;APLA000781-PA;APLA005342-PA;APLA003043-PA;APLA002461-PA;APLA015273-PA;APLA007395-PA;APLA014241-PA;APLA013661-PA;APLA001849-PA;APLA005783-PA;APLA005907-PA;APLA002946-PA;APLA007691-PA;APLA008649-PA;APLA002687-PA;APLA014501-PA;APLA005364-PA;APLA001620-PA;APLA009052-PA;APLA008948-PA Reactome: R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 2 APLA000428-PA;APLA005832-PA Reactome: R-HSA-9610379 HCMV Late Events 23 APLA003482-PA;APLA008872-PA;APLA010643-PA;APLA002444-PA;APLA014725-PA;APLA001407-PA;APLA011447-PA;APLA003608-PA;APLA001290-PA;APLA004137-PA;APLA006060-PA;APLA015058-PA;APLA005195-PA;APLA011986-PA;APLA005336-PA;APLA000426-PA;APLA005231-PA;APLA002236-PA;APLA005565-PA;APLA003018-PA;APLA002878-PA;APLA000427-PA;APLA009708-PA Reactome: R-HSA-420029 Tight junction interactions 1 APLA005391-PA KEGG: 00730+2.2.1.7 Thiamine metabolism 1 APLA003487-PA KEGG: 00770+2.7.1.33 Pantothenate and CoA biosynthesis 1 APLA007948-PA Reactome: R-HSA-70921 Histidine catabolism 2 APLA012568-PA;APLA007174-PA Reactome: R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 13 APLA007857-PA;APLA015064-PA;APLA012425-PA;APLA008152-PA;APLA000043-PA;APLA013496-PA;APLA002547-PA;APLA003680-PA;APLA004459-PA;APLA002545-PA;APLA002072-PA;APLA000828-PA;APLA001403-PA Reactome: R-HSA-977347 Serine biosynthesis 2 APLA014671-PA;APLA007352-PA MetaCyc: PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I 1 APLA006918-PA MetaCyc: PWY-7282 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis 4 APLA007551-PA;APLA012135-PA;APLA013280-PA;APLA008936-PA KEGG: 00720+4.2.1.2 Carbon fixation pathways in prokaryotes 1 APLA003089-PA Reactome: R-HSA-437239 Recycling pathway of L1 20 APLA008446-PA;APLA010196-PA;APLA014048-PA;APLA014998-PA;APLA012338-PA;APLA007858-PA;APLA014850-PA;APLA013359-PA;APLA002551-PA;APLA010596-PA;APLA013357-PA;APLA008115-PA;APLA015031-PA;APLA001953-PA;APLA001793-PA;APLA010198-PA;APLA009417-PA;APLA010197-PA;APLA015416-PA;APLA004383-PA Reactome: R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 7 APLA008490-PA;APLA009436-PA;APLA006438-PA;APLA008489-PA;APLA009473-PA;APLA008801-PA;APLA009856-PA Reactome: R-HSA-72649 Translation initiation complex formation 45 APLA005697-PA;APLA001093-PA;APLA014029-PA;APLA007319-PA;APLA004503-PA;APLA005706-PA;APLA015388-PA;APLA001686-PA;APLA012910-PA;APLA003064-PA;APLA013210-PA;APLA005384-PA;APLA005196-PA;APLA009234-PA;APLA001987-PA;APLA003286-PA;APLA007956-PA;APLA006227-PA;APLA013308-PA;APLA015197-PA;APLA005454-PA;APLA003509-PA;APLA005476-PA;APLA000130-PA;APLA002625-PA;APLA002114-PA;APLA005999-PA;APLA012185-PA;APLA009753-PA;APLA004544-PA;APLA008588-PA;APLA006586-PA;APLA002086-PA;APLA000050-PA;APLA003102-PA;APLA006079-PA;APLA003770-PA;APLA003093-PA;APLA014343-PA;APLA014272-PA;APLA000682-PA;APLA013231-PA;APLA003269-PA;APLA010040-PA;APLA002294-PA Reactome: R-HSA-9603798 Class I peroxisomal membrane protein import 7 APLA008708-PA;APLA003946-PA;APLA010136-PA;APLA000667-PA;APLA014838-PA;APLA001142-PA;APLA005912-PA MetaCyc: PWY-8086 (S)-lactate fermentation to propanoate, acetate and hydrogen 7 APLA000736-PA;APLA003089-PA;APLA015456-PA;APLA013385-PA;APLA005378-PA;APLA000737-PA;APLA000684-PA KEGG: 00650+2.6.1.19 Butanoate metabolism 1 APLA003896-PA KEGG: 00020+2.3.3.8 Citrate cycle (TCA cycle) 1 APLA001878-PA MetaCyc: PWY-7197 Pyrimidine deoxyribonucleotide phosphorylation 4 APLA002995-PA;APLA001202-PA;APLA009372-PA;APLA000359-PA Reactome: R-HSA-5223345 Miscellaneous transport and binding events 1 APLA007353-PA Reactome: R-HSA-432720 Lysosome Vesicle Biogenesis 5 APLA005077-PA;APLA005913-PA;APLA000454-PA;APLA008679-PA;APLA010150-PA Reactome: R-HSA-5685942 HDR through Homologous Recombination (HRR) 30 APLA000365-PA;APLA013151-PA;APLA003353-PA;APLA008808-PA;APLA009824-PA;APLA001691-PA;APLA002790-PA;APLA009424-PA;APLA014272-PA;APLA003193-PA;APLA014443-PA;APLA006016-PA;APLA005141-PA;APLA014841-PA;APLA000884-PA;APLA010387-PA;APLA014545-PA;APLA012406-PA;APLA009590-PA;APLA002288-PA;APLA006643-PA;APLA009662-PA;APLA008283-PA;APLA006644-PA;APLA013848-PA;APLA001459-PA;APLA002832-PA;APLA014958-PA;APLA005000-PA;APLA002022-PA MetaCyc: PWY-1801 Formaldehyde oxidation II (glutathione-dependent) 2 APLA001970-PA;APLA008280-PA MetaCyc: PWY-5695 Inosine 5'-phosphate degradation 5 APLA013738-PA;APLA000262-PA;APLA002282-PA;APLA003519-PA;APLA002333-PA KEGG: 00640+6.2.1.4 Propanoate metabolism 1 APLA010449-PA MetaCyc: PWY-8051 Anandamide biosynthesis I 18 APLA014471-PA;APLA012384-PA;APLA009079-PA;APLA004469-PA;APLA000543-PA;APLA005748-PA;APLA012865-PA;APLA002667-PA;APLA001595-PA;APLA004147-PA;APLA009078-PA;APLA008027-PA;APLA009816-PA;APLA008047-PA;APLA002539-PA;APLA005749-PA;APLA001975-PA;APLA012686-PA KEGG: 00627+4.2.1.17 Aminobenzoate degradation 4 APLA000468-PA;APLA014896-PA;APLA006178-PA;APLA006174-PA Reactome: R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 21 APLA010151-PA;APLA008767-PA;APLA011846-PA;APLA000454-PA;APLA000054-PA;APLA003544-PA;APLA014272-PA;APLA005077-PA;APLA009419-PA;APLA013969-PA;APLA014546-PA;APLA002404-PA;APLA003678-PA;APLA002555-PA;APLA002288-PA;APLA008115-PA;APLA004465-PA;APLA001793-PA;APLA002124-PA;APLA011412-PA;APLA010150-PA Reactome: R-HSA-202040 G-protein activation 2 APLA003536-PA;APLA013772-PA KEGG: 00030+1.1.1.49 Pentose phosphate pathway 1 APLA005622-PA MetaCyc: PWY-8055 Palmitoyl ethanolamide biosynthesis 8 APLA009816-PA;APLA002667-PA;APLA014471-PA;APLA004147-PA;APLA008027-PA;APLA000543-PA;APLA001595-PA;APLA012686-PA MetaCyc: PWY-7996 Menaquinol-4 biosynthesis I 1 APLA015235-PA KEGG: 00533+2.4.1.68 Glycosaminoglycan biosynthesis - keratan sulfate 2 APLA014868-PA;APLA014869-PA KEGG: 00051+5.3.1.5 Fructose and mannose metabolism 1 APLA002051-PA KEGG: 00940+1.11.1.7 Phenylpropanoid biosynthesis 1 APLA014196-PA Reactome: R-HSA-5683371 Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7) 1 APLA000690-PA KEGG: 00970+6.1.1.16 Aminoacyl-tRNA biosynthesis 2 APLA004626-PA;APLA001985-PA MetaCyc: PWY-6608 Guanosine nucleotides degradation III 4 APLA002333-PA;APLA002282-PA;APLA000262-PA;APLA013738-PA Reactome: R-HSA-4793952 Defective MGAT2 causes MGAT2-CDG (CDG-2a) 2 APLA007125-PA;APLA012410-PA Reactome: R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 6 APLA014264-PA;APLA011103-PA;APLA005357-PA;APLA000777-PA;APLA014272-PA;APLA002288-PA KEGG: 00630+2.1.2.1 Glyoxylate and dicarboxylate metabolism 1 APLA000499-PA MetaCyc: PWY-7176 UTP and CTP de novo biosynthesis 5 APLA000359-PA;APLA014549-PA;APLA009372-PA;APLA002995-PA;APLA010349-PA Reactome: R-HSA-162594 Early Phase of HIV Life Cycle 1 APLA001840-PA KEGG: 00908+2.5.1.75 Zeatin biosynthesis 1 APLA013811-PA Reactome: R-HSA-418990 Adherens junctions interactions 2 APLA002343-PA;APLA011730-PA Reactome: R-HSA-8948751 Regulation of PTEN stability and activity 35 APLA014016-PA;APLA002873-PA;APLA014272-PA;APLA002428-PA;APLA001313-PA;APLA012977-PA;APLA012828-PA;APLA015028-PA;APLA013223-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA012840-PA;APLA006943-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA010460-PA;APLA004504-PA;APLA008686-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA011713-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA008987-PA;APLA008836-PA;APLA000126-PA;APLA011706-PA;APLA006975-PA;APLA000810-PA Reactome: R-HSA-168325 Viral Messenger RNA Synthesis 28 APLA006899-PA;APLA008112-PA;APLA000426-PA;APLA005336-PA;APLA005231-PA;APLA011986-PA;APLA008108-PA;APLA005565-PA;APLA002878-PA;APLA014999-PA;APLA009708-PA;APLA014520-PA;APLA000427-PA;APLA002444-PA;APLA003482-PA;APLA010643-PA;APLA003046-PA;APLA003842-PA;APLA015000-PA;APLA000743-PA;APLA011447-PA;APLA001290-PA;APLA013703-PA;APLA014037-PA;APLA015058-PA;APLA004137-PA;APLA006060-PA;APLA001551-PA Reactome: R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 1 APLA009848-PA MetaCyc: PWY-6945 Cholesterol degradation to androstenedione I (cholesterol oxidase) 4 APLA006174-PA;APLA014896-PA;APLA006178-PA;APLA000468-PA KEGG: 00230+2.7.7.4 Purine metabolism 1 APLA000768-PA KEGG: 00900+2.5.1.58 Terpenoid backbone biosynthesis 1 APLA001848-PA KEGG: 00040+5.3.1.5 Pentose and glucuronate interconversions 1 APLA002051-PA KEGG: 00051+2.7.1.11 Fructose and mannose metabolism 2 APLA013705-PA;APLA013706-PA Reactome: R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 25 APLA013383-PA;APLA007945-PA;APLA006113-PA;APLA007136-PA;APLA001407-PA;APLA002675-PA;APLA002288-PA;APLA005949-PA;APLA006117-PA;APLA014713-PA;APLA011837-PA;APLA005953-PA;APLA000606-PA;APLA001380-PA;APLA005011-PA;APLA001514-PA;APLA005175-PA;APLA008497-PA;APLA008956-PA;APLA009966-PA;APLA008509-PA;APLA014272-PA;APLA005176-PA;APLA008278-PA;APLA006607-PA Reactome: R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated 3 APLA001633-PA;APLA010601-PA;APLA003480-PA Reactome: R-HSA-977225 Amyloid fiber formation 7 APLA012600-PA;APLA013918-PA;APLA000730-PA;APLA002288-PA;APLA005953-PA;APLA014272-PA;APLA014713-PA Reactome: R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 1 APLA000323-PA Reactome: R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 2 APLA012988-PA;APLA015425-PA Reactome: R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 21 APLA010986-PA;APLA014037-PA;APLA013703-PA;APLA000879-PA;APLA012981-PA;APLA001551-PA;APLA003046-PA;APLA003279-PA;APLA003842-PA;APLA015000-PA;APLA000743-PA;APLA008108-PA;APLA014999-PA;APLA009703-PA;APLA014520-PA;APLA010731-PA;APLA001596-PA;APLA008112-PA;APLA006899-PA;APLA001624-PA;APLA000547-PA KEGG: 00010+5.1.3.3 Glycolysis / Gluconeogenesis 2 APLA015199-PA;APLA012066-PA KEGG: 04070+2.7.11.13 Phosphatidylinositol signaling system 2 APLA002092-PA;APLA000948-PA KEGG: 00860+4.99.1.1 Porphyrin and chlorophyll metabolism 1 APLA003637-PA Reactome: R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 2 APLA012074-PA;APLA012869-PA Reactome: R-HSA-1566948 Elastic fibre formation 1 APLA002318-PA Reactome: R-HSA-5637810 Constitutive Signaling by EGFRvIII 1 APLA009848-PA Reactome: R-HSA-427652 Sodium-coupled phosphate cotransporters 1 APLA002412-PA KEGG: 00670+1.5.1.6 One carbon pool by folate 1 APLA005950-PA KEGG: 00720+6.2.1.1 Carbon fixation pathways in prokaryotes 2 APLA008135-PA;APLA006387-PA Reactome: R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 14 APLA000862-PA;APLA009871-PA;APLA010068-PA;APLA002710-PA;APLA005258-PA;APLA015433-PA;APLA010065-PA;APLA010066-PA;APLA010067-PA;APLA010062-PA;APLA010064-PA;APLA010063-PA;APLA008114-PA;APLA000863-PA Reactome: R-HSA-202433 Generation of second messenger molecules 1 APLA014442-PA Reactome: R-HSA-5689896 Ovarian tumor domain proteases 6 APLA010601-PA;APLA006577-PA;APLA002288-PA;APLA008790-PA;APLA014272-PA;APLA003316-PA KEGG: 00250+6.3.1.2 Alanine, aspartate and glutamate metabolism 1 APLA000323-PA Reactome: R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 1 APLA009848-PA KEGG: 00770+6.3.2.5 Pantothenate and CoA biosynthesis 1 APLA015353-PA KEGG: 00626+1.1.1.1 Naphthalene degradation 1 APLA001970-PA Reactome: R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 5 APLA007229-PA;APLA005637-PA;APLA014759-PA;APLA008510-PA;APLA000500-PA Reactome: R-HSA-381038 XBP1(S) activates chaperone genes 6 APLA009443-PA;APLA012684-PA;APLA013278-PA;APLA002087-PA;APLA008693-PA;APLA015228-PA KEGG: 00970+6.1.1.5 Aminoacyl-tRNA biosynthesis 2 APLA005238-PA;APLA005781-PA Reactome: R-HSA-72702 Ribosomal scanning and start codon recognition 47 APLA015197-PA;APLA013308-PA;APLA006227-PA;APLA005196-PA;APLA007956-PA;APLA003286-PA;APLA001987-PA;APLA009234-PA;APLA013210-PA;APLA003064-PA;APLA012910-PA;APLA005384-PA;APLA007319-PA;APLA014029-PA;APLA001093-PA;APLA005697-PA;APLA001686-PA;APLA015388-PA;APLA005706-PA;APLA004503-PA;APLA014441-PA;APLA013231-PA;APLA002294-PA;APLA010040-PA;APLA006555-PA;APLA003269-PA;APLA006079-PA;APLA003102-PA;APLA000050-PA;APLA002086-PA;APLA000682-PA;APLA014272-PA;APLA014343-PA;APLA003770-PA;APLA003093-PA;APLA004544-PA;APLA009753-PA;APLA012185-PA;APLA002114-PA;APLA005999-PA;APLA006586-PA;APLA008588-PA;APLA005476-PA;APLA003509-PA;APLA005454-PA;APLA002625-PA;APLA000130-PA Reactome: R-HSA-8941332 RUNX2 regulates genes involved in cell migration 2 APLA008489-PA;APLA008490-PA Reactome: R-HSA-1483191 Synthesis of PC 10 APLA015192-PA;APLA006184-PA;APLA007870-PA;APLA008714-PA;APLA007820-PA;APLA003107-PA;APLA011782-PA;APLA012840-PA;APLA009874-PA;APLA001595-PA Reactome: R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 1 APLA007949-PA Reactome: R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 9 APLA012071-PA;APLA000807-PA;APLA002315-PA;APLA012128-PA;APLA001404-PA;APLA004868-PA;APLA000249-PA;APLA011749-PA;APLA009098-PA MetaCyc: PWY-7082 Ammonia oxidation IV (autotrophic ammonia oxidizers) 1 APLA000133-PA Reactome: R-HSA-912526 Interleukin receptor SHC signaling 1 APLA012421-PA Reactome: R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 33 APLA015028-PA;APLA013223-PA;APLA012977-PA;APLA014272-PA;APLA002873-PA;APLA002428-PA;APLA001313-PA;APLA014016-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA006943-PA;APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA011713-PA;APLA013844-PA;APLA015189-PA;APLA004494-PA;APLA008686-PA;APLA004504-PA;APLA010460-PA;APLA000126-PA;APLA008836-PA;APLA011706-PA;APLA006975-PA;APLA000810-PA;APLA008987-PA;APLA001601-PA;APLA013968-PA;APLA005704-PA MetaCyc: PWY-7158 L-phenylalanine degradation V 2 APLA006614-PA;APLA014138-PA KEGG: 00670+2.1.2.10 One carbon pool by folate 2 APLA005967-PA;APLA006599-PA KEGG: 00710+5.3.1.1 Carbon fixation in photosynthetic organisms 1 APLA006547-PA KEGG: 00260+1.1.1.1 Glycine, serine and threonine metabolism 1 APLA001970-PA Reactome: R-HSA-611105 Respiratory electron transport 68 APLA001620-PA;APLA008948-PA;APLA013956-PA;APLA007691-PA;APLA008649-PA;APLA002687-PA;APLA002724-PA;APLA008650-PA;APLA005907-PA;APLA001849-PA;APLA009901-PA;APLA002461-PA;APLA012845-PA;APLA012855-PA;APLA010056-PA;APLA005010-PA;APLA005591-PA;APLA007915-PA;APLA005031-PA;APLA001852-PA;APLA015229-PA;APLA000357-PA;APLA000822-PA;APLA008155-PA;APLA012074-PA;APLA013330-PA;APLA011836-PA;APLA006636-PA;APLA005364-PA;APLA002582-PA;APLA014501-PA;APLA010175-PA;APLA012224-PA;APLA002946-PA;APLA013610-PA;APLA006254-PA;APLA005783-PA;APLA002332-PA;APLA007395-PA;APLA014241-PA;APLA013661-PA;APLA009900-PA;APLA003262-PA;APLA009245-PA;APLA004808-PA;APLA005633-PA;APLA006770-PA;APLA000781-PA;APLA013308-PA;APLA010752-PA;APLA012616-PA;APLA009642-PA;APLA010532-PA;APLA010437-PA;APLA011710-PA;APLA004506-PA;APLA008250-PA;APLA005412-PA;APLA012188-PA;APLA008157-PA;APLA014026-PA;APLA013736-PA;APLA015489-PA;APLA014842-PA;APLA001549-PA;APLA001690-PA;APLA000601-PA;APLA005367-PA Reactome: R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 2 APLA011837-PA;APLA001514-PA Reactome: R-HSA-174430 Telomere C-strand synthesis initiation 7 APLA008612-PA;APLA006690-PA;APLA007371-PA;APLA008283-PA;APLA014513-PA;APLA006016-PA;APLA008659-PA KEGG: 00030+5.3.1.6 Pentose phosphate pathway 1 APLA000025-PA KEGG: 00360+1.14.16.1 Phenylalanine metabolism 1 APLA006614-PA Reactome: R-HSA-5654706 FRS-mediated FGFR3 signaling 1 APLA005551-PA Reactome: R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 7 APLA009847-PA;APLA007870-PA;APLA009226-PA;APLA006184-PA;APLA007710-PA;APLA003107-PA;APLA005893-PA Reactome: R-HSA-392154 Nitric oxide stimulates guanylate cyclase 7 APLA011553-PA;APLA004212-PA;APLA011554-PA;APLA015356-PA;APLA008917-PA;APLA001410-PA;APLA001413-PA MetaCyc: PWY-7887 Protein SAMPylation and SAMP-mediated thiolation 1 APLA014022-PA MetaCyc: PWY-7589 Palmitoleate biosynthesis III (cyanobacteria) 5 APLA000543-PA;APLA008027-PA;APLA004147-PA;APLA014471-PA;APLA012686-PA KEGG: 00053+1.8.5.1 Ascorbate and aldarate metabolism 1 APLA014577-PA KEGG: 00230+3.5.2.17 Purine metabolism 1 APLA000730-PA Reactome: R-HSA-174437 Removal of the Flap Intermediate from the C-strand 9 APLA001840-PA;APLA013151-PA;APLA003353-PA;APLA001691-PA;APLA002832-PA;APLA003193-PA;APLA005141-PA;APLA014841-PA;APLA014545-PA KEGG: 00600+3.1.3.4 Sphingolipid metabolism 1 APLA001595-PA KEGG: 00130+1.14.99.60 Ubiquinone and other terpenoid-quinone biosynthesis 1 APLA002418-PA Reactome: R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 4 APLA011048-PA;APLA001537-PA;APLA012570-PA;APLA006918-PA Reactome: R-HSA-400206 Regulation of lipid metabolism by PPARalpha 5 APLA003680-PA;APLA004459-PA;APLA008152-PA;APLA015064-PA;APLA008801-PA KEGG: 00970+6.1.1.20 Aminoacyl-tRNA biosynthesis 4 APLA001944-PA;APLA014354-PA;APLA011973-PA;APLA013122-PA Reactome: R-HSA-74217 Purine salvage 9 APLA015153-PA;APLA001446-PA;APLA000262-PA;APLA006729-PA;APLA009855-PA;APLA006726-PA;APLA001538-PA;APLA014477-PA;APLA013738-PA MetaCyc: PWY-7269 NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast) 2 APLA011044-PA;APLA013222-PA MetaCyc: PWY-5873 Ubiquinol-7 biosynthesis (eukaryotic) 1 APLA002418-PA KEGG: 00565+3.1.1.4 Ether lipid metabolism 7 APLA001975-PA;APLA009079-PA;APLA009078-PA;APLA004469-PA;APLA012384-PA;APLA005749-PA;APLA005748-PA Reactome: R-HSA-2871809 FCERI mediated Ca+2 mobilization 3 APLA003653-PA;APLA005249-PA;APLA014442-PA Reactome: R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3 APLA001000-PA;APLA010885-PA;APLA007154-PA MetaCyc: PWY-6470 Peptidoglycan biosynthesis V (beta-lactam resistance) 2 APLA002213-PA;APLA009515-PA MetaCyc: PWY-7115 C4 photosynthetic carbon assimilation cycle, NAD-ME type 8 APLA008850-PA;APLA002692-PA;APLA005378-PA;APLA015456-PA;APLA012983-PA;APLA000684-PA;APLA012145-PA;APLA014966-PA KEGG: 00062+2.3.1.199 Fatty acid elongation 12 APLA010068-PA;APLA009871-PA;APLA000862-PA;APLA010066-PA;APLA015433-PA;APLA010065-PA;APLA002710-PA;APLA010067-PA;APLA000863-PA;APLA010063-PA;APLA010064-PA;APLA010062-PA MetaCyc: PWY-5872 Ubiquinol-10 biosynthesis (eukaryotic) 1 APLA002418-PA Reactome: R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 1 APLA002140-PA Reactome: R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 1 APLA004368-PA MetaCyc: PWY-6556 Pyrimidine ribonucleosides salvage II 1 APLA000366-PA KEGG: 00511+3.2.1.51 Other glycan degradation 2 APLA008561-PA;APLA013714-PA Reactome: R-HSA-6804757 Regulation of TP53 Degradation 8 APLA002288-PA;APLA013745-PA;APLA010399-PA;APLA011144-PA;APLA014272-PA;APLA014094-PA;APLA005545-PA;APLA001194-PA Reactome: R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 2 APLA011270-PA;APLA005702-PA MetaCyc: PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 2 APLA001933-PA;APLA005085-PA Reactome: R-HSA-975871 MyD88 cascade initiated on plasma membrane 1 APLA015273-PA Reactome: R-HSA-3299685 Detoxification of Reactive Oxygen Species 37 APLA004582-PA;APLA014953-PA;APLA014955-PA;APLA000555-PA;APLA004182-PA;APLA013807-PA;APLA001069-PA;APLA004588-PA;APLA004307-PA;APLA004174-PA;APLA004171-PA;APLA005612-PA;APLA012790-PA;APLA008339-PA;APLA006341-PA;APLA013736-PA;APLA001684-PA;APLA004175-PA;APLA001010-PA;APLA004172-PA;APLA001009-PA;APLA015327-PA;APLA004173-PA;APLA000554-PA;APLA011061-PA;APLA004184-PA;APLA009642-PA;APLA012681-PA;APLA008209-PA;APLA004183-PA;APLA000848-PA;APLA009588-PA;APLA001904-PA;APLA002967-PA;APLA006339-PA;APLA001011-PA;APLA001070-PA KEGG: 00480+6.3.2.3 Glutathione metabolism 2 APLA011246-PA;APLA011248-PA Reactome: R-HSA-1474228 Degradation of the extracellular matrix 8 APLA005953-PA;APLA009585-PA;APLA004965-PA;APLA009094-PA;APLA008555-PA;APLA012829-PA;APLA008553-PA;APLA000382-PA Reactome: R-HSA-8847993 ERBB2 Activates PTK6 Signaling 1 APLA006305-PA KEGG: 00592+3.1.1.4 alpha-Linolenic acid metabolism 7 APLA012384-PA;APLA001975-PA;APLA009078-PA;APLA009079-PA;APLA004469-PA;APLA005749-PA;APLA005748-PA Reactome: R-HSA-69166 Removal of the Flap Intermediate 14 APLA013151-PA;APLA001840-PA;APLA003353-PA;APLA006690-PA;APLA008659-PA;APLA005141-PA;APLA014513-PA;APLA001691-PA;APLA003193-PA;APLA002832-PA;APLA014545-PA;APLA007371-PA;APLA014841-PA;APLA008612-PA KEGG: 00514+2.4.1.109 Other types of O-glycan biosynthesis 6 APLA008830-PA;APLA008605-PA;APLA007195-PA;APLA010474-PA;APLA007255-PA;APLA012979-PA MetaCyc: PWY-7799 Arg/N-end rule pathway (eukaryotic) 6 APLA008803-PA;APLA000926-PA;APLA010400-PA;APLA004629-PA;APLA003133-PA;APLA000090-PA Reactome: R-HSA-5693607 Processing of DNA double-strand break ends 25 APLA003353-PA;APLA007822-PA;APLA005141-PA;APLA014443-PA;APLA003193-PA;APLA014272-PA;APLA014377-PA;APLA003151-PA;APLA009424-PA;APLA002493-PA;APLA014545-PA;APLA000884-PA;APLA002383-PA;APLA002288-PA;APLA004238-PA;APLA001541-PA;APLA012406-PA;APLA007864-PA;APLA009662-PA;APLA007521-PA;APLA006643-PA;APLA002832-PA;APLA001459-PA;APLA005000-PA;APLA014958-PA Reactome: R-HSA-2142789 Ubiquinol biosynthesis 4 APLA002418-PA;APLA015235-PA;APLA013577-PA;APLA004760-PA KEGG: 00564+4.1.1.65 Glycerophospholipid metabolism 1 APLA009513-PA KEGG: 00860+4.2.1.24 Porphyrin and chlorophyll metabolism 1 APLA002965-PA Reactome: R-HSA-74749 Signal attenuation 1 APLA002140-PA Reactome: R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 6 APLA008067-PA;APLA007715-PA;APLA014433-PA;APLA013214-PA;APLA002390-PA;APLA001663-PA MetaCyc: PWY-5041 S-adenosyl-L-methionine cycle II 3 APLA012141-PA;APLA008908-PA;APLA006390-PA Reactome: R-HSA-425561 Sodium/Calcium exchangers 9 APLA004615-PA;APLA010550-PA;APLA004617-PA;APLA004609-PA;APLA010384-PA;APLA004610-PA;APLA010382-PA;APLA010385-PA;APLA010381-PA MetaCyc: PWY-5108 L-isoleucine biosynthesis V 3 APLA006387-PA;APLA006327-PA;APLA008135-PA Reactome: R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 1 APLA012596-PA Reactome: R-HSA-180746 Nuclear import of Rev protein 17 APLA002444-PA;APLA010643-PA;APLA003482-PA;APLA001290-PA;APLA011447-PA;APLA015058-PA;APLA008660-PA;APLA004137-PA;APLA006060-PA;APLA000426-PA;APLA005231-PA;APLA005336-PA;APLA011986-PA;APLA002878-PA;APLA005565-PA;APLA009708-PA;APLA000427-PA KEGG: 00790+4.1.99.22 Folate biosynthesis 2 APLA008006-PA;APLA008007-PA Reactome: R-HSA-72165 mRNA Splicing - Minor Pathway 31 APLA000807-PA;APLA005894-PA;APLA014430-PA;APLA008108-PA;APLA007701-PA;APLA015233-PA;APLA014520-PA;APLA000176-PA;APLA014999-PA;APLA008112-PA;APLA006899-PA;APLA008204-PA;APLA008643-PA;APLA010637-PA;APLA001836-PA;APLA014037-PA;APLA013703-PA;APLA001551-PA;APLA000699-PA;APLA012002-PA;APLA007536-PA;APLA004454-PA;APLA002938-PA;APLA007133-PA;APLA003046-PA;APLA007670-PA;APLA002937-PA;APLA004191-PA;APLA000743-PA;APLA015000-PA;APLA003842-PA MetaCyc: PWY-8099 Tetrahydropteridine recycling 1 APLA014138-PA MetaCyc: PWY-6344 L-ornithine degradation II (Stickland reaction) 3 APLA008941-PA;APLA001395-PA;APLA011286-PA Reactome: R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 12 APLA005953-PA;APLA005011-PA;APLA002288-PA;APLA007945-PA;APLA007136-PA;APLA006113-PA;APLA014713-PA;APLA014272-PA;APLA006117-PA;APLA008497-PA;APLA008509-PA;APLA009966-PA Reactome: R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 28 APLA006345-PA;APLA013357-PA;APLA001600-PA;APLA010596-PA;APLA002551-PA;APLA013359-PA;APLA014850-PA;APLA012338-PA;APLA007858-PA;APLA014998-PA;APLA014048-PA;APLA008446-PA;APLA010196-PA;APLA004383-PA;APLA004453-PA;APLA015416-PA;APLA010197-PA;APLA009417-PA;APLA015241-PA;APLA015228-PA;APLA010198-PA;APLA010434-PA;APLA001603-PA;APLA014536-PA;APLA003210-PA;APLA001953-PA;APLA002757-PA;APLA015031-PA MetaCyc: PWY-5147 Oleate biosynthesis I (plants) 3 APLA007857-PA;APLA002545-PA;APLA002072-PA Reactome: R-HSA-190861 Gap junction assembly 18 APLA013359-PA;APLA010596-PA;APLA002551-PA;APLA013357-PA;APLA008446-PA;APLA010196-PA;APLA014048-PA;APLA014998-PA;APLA012338-PA;APLA007858-PA;APLA014850-PA;APLA010198-PA;APLA009417-PA;APLA010197-PA;APLA015416-PA;APLA004383-PA;APLA015031-PA;APLA001953-PA Reactome: R-HSA-180585 Vif-mediated degradation of APOBEC3G 33 APLA010460-PA;APLA004504-PA;APLA011713-PA;APLA004494-PA;APLA013844-PA;APLA015189-PA;APLA008686-PA;APLA001601-PA;APLA013968-PA;APLA005704-PA;APLA000810-PA;APLA006975-PA;APLA011706-PA;APLA000126-PA;APLA008836-PA;APLA008987-PA;APLA001313-PA;APLA014272-PA;APLA002873-PA;APLA002428-PA;APLA014016-PA;APLA013223-PA;APLA015028-PA;APLA012977-PA;APLA012593-PA;APLA005719-PA;APLA007463-PA;APLA010347-PA;APLA005756-PA;APLA010995-PA;APLA002288-PA;APLA010791-PA;APLA006943-PA Reactome: R-HSA-375165 NCAM signaling for neurite out-growth 3 APLA011027-PA;APLA001292-PA;APLA002140-PA Reactome: R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 2 APLA008490-PA;APLA008489-PA MetaCyc: PWY-5530 Sorbitol biosynthesis II 1 APLA005270-PA KEGG: 00190+1.3.5.1 Oxidative phosphorylation 5 APLA015489-PA;APLA003262-PA;APLA006254-PA;APLA000357-PA;APLA013330-PA MetaCyc: PWY-1861 Formaldehyde assimilation II (assimilatory RuMP Cycle) 7 APLA008988-PA;APLA013705-PA;APLA015453-PA;APLA000619-PA;APLA000565-PA;APLA013706-PA;APLA000025-PA Reactome: R-HSA-1482922 Acyl chain remodelling of PI 4 APLA009079-PA;APLA004469-PA;APLA005748-PA;APLA005749-PA Reactome: R-HSA-6802952 Signaling by BRAF and RAF fusions 6 APLA013801-PA;APLA007030-PA;APLA001451-PA;APLA009089-PA;APLA001089-PA;APLA002140-PA Reactome: R-HSA-8943724 Regulation of PTEN gene transcription 14 APLA008732-PA;APLA008535-PA;APLA005702-PA;APLA009658-PA;APLA002140-PA;APLA011270-PA;APLA002692-PA;APLA000162-PA;APLA010562-PA;APLA010301-PA;APLA014094-PA;APLA008538-PA;APLA005545-PA;APLA009758-PA KEGG: 00790+3.1.3.1 Folate biosynthesis 11 APLA005796-PA;APLA007909-PA;APLA008562-PA;APLA007910-PA;APLA007908-PA;APLA004280-PA;APLA004522-PA;APLA004282-PA;APLA007911-PA;APLA013467-PA;APLA008563-PA Reactome: R-HSA-2299718 Condensation of Prophase Chromosomes 4 APLA008756-PA;APLA003426-PA;APLA005777-PA;APLA006635-PA MetaCyc: PWY-8049 Pederin biosynthesis 3 APLA002545-PA;APLA002072-PA;APLA007857-PA KEGG: 00511+3.2.1.24 Other glycan degradation 3 APLA008429-PA;APLA008430-PA;APLA004632-PA Reactome: R-HSA-5625970 RHO GTPases activate KTN1 2 APLA004850-PA;APLA004714-PA Reactome: R-HSA-5620924 Intraflagellar transport 11 APLA013455-PA;APLA004696-PA;APLA007219-PA;APLA010274-PA;APLA011261-PA;APLA004904-PA;APLA001435-PA;APLA007143-PA;APLA006563-PA;APLA004330-PA;APLA011992-PA Reactome: R-HSA-390450 Folding of actin by CCT/TriC 8 APLA014519-PA;APLA014716-PA;APLA007959-PA;APLA005863-PA;APLA009217-PA;APLA009349-PA;APLA008961-PA;APLA000049-PA MetaCyc: PWY-7159 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) 3 APLA007924-PA;APLA001914-PA;APLA008197-PA KEGG: 00500+2.4.1.1 Starch and sucrose metabolism 2 APLA006828-PA;APLA006822-PA KEGG: 00051+5.3.1.6 Fructose and mannose metabolism 1 APLA000025-PA Reactome: R-HSA-68867 Assembly of the pre-replicative complex 18 APLA010598-PA;APLA008067-PA;APLA006695-PA;APLA001388-PA;APLA001663-PA;APLA014775-PA;APLA013902-PA;APLA014433-PA;APLA013214-PA;APLA002390-PA;APLA006933-PA;APLA008611-PA;APLA001307-PA;APLA001682-PA;APLA008613-PA;APLA011532-PA;APLA007715-PA;APLA010172-PA KEGG: 00966+2.6.1.42 Glucosinolate biosynthesis 1 APLA006327-PA Reactome: R-HSA-6794361 Neurexins and neuroligins 6 APLA012736-PA;APLA003259-PA;APLA009144-PA;APLA014051-PA;APLA014133-PA;APLA008807-PA KEGG: 00240+2.4.2.1 Pyrimidine metabolism 2 APLA013738-PA;APLA000262-PA MetaCyc: PWY-7587 Oleate biosynthesis III (cyanobacteria) 7 APLA004147-PA;APLA014471-PA;APLA000543-PA;APLA008027-PA;APLA009816-PA;APLA002667-PA;APLA012686-PA Reactome: R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 2 APLA012413-PA;APLA011061-PA Reactome: R-HSA-192823 Viral mRNA Translation 71 APLA014985-PA;APLA014272-PA;APLA014343-PA;APLA012986-PA;APLA012226-PA;APLA008225-PA;APLA010040-PA;APLA002294-PA;APLA003509-PA;APLA005454-PA;APLA007375-PA;APLA000130-PA;APLA000210-PA;APLA002625-PA;APLA014444-PA;APLA002114-PA;APLA002288-PA;APLA011333-PA;APLA010469-PA;APLA013308-PA;APLA014046-PA;APLA003014-PA;APLA005697-PA;APLA014384-PA;APLA005706-PA;APLA006618-PA;APLA000605-PA;APLA013210-PA;APLA012910-PA;APLA006079-PA;APLA003102-PA;APLA002086-PA;APLA005265-PA;APLA010605-PA;APLA000682-PA;APLA003770-PA;APLA009495-PA;APLA013231-PA;APLA010999-PA;APLA003269-PA;APLA005404-PA;APLA009213-PA;APLA008614-PA;APLA013392-PA;APLA010839-PA;APLA004544-PA;APLA009753-PA;APLA012185-PA;APLA000488-PA;APLA004075-PA;APLA010013-PA;APLA008588-PA;APLA007956-PA;APLA014107-PA;APLA009234-PA;APLA006379-PA;APLA007492-PA;APLA008766-PA;APLA009149-PA;APLA001622-PA;APLA006227-PA;APLA012911-PA;APLA012151-PA;APLA001686-PA;APLA003217-PA;APLA015388-PA;APLA011066-PA;APLA012609-PA;APLA003064-PA;APLA000956-PA;APLA005384-PA Reactome: R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 16 APLA008984-PA;APLA014841-PA;APLA014272-PA;APLA001691-PA;APLA008790-PA;APLA004141-PA;APLA003946-PA;APLA007972-PA;APLA000667-PA;APLA002009-PA;APLA007667-PA;APLA014838-PA;APLA008519-PA;APLA007576-PA;APLA008228-PA;APLA002288-PA Reactome: R-HSA-2160916 Hyaluronan uptake and degradation 6 APLA003010-PA;APLA001817-PA;APLA002044-PA;APLA006026-PA;APLA012599-PA;APLA005795-PA KEGG: 00270+2.5.1.16 Cysteine and methionine metabolism 2 APLA000590-PA;APLA003859-PA KEGG: 00710+2.7.2.3 Carbon fixation in photosynthetic organisms 2 APLA003818-PA;APLA003817-PA MetaCyc: PWY-5189 Tetrapyrrole biosynthesis II (from glycine) 4 APLA008273-PA;APLA002668-PA;APLA010645-PA;APLA002965-PA Reactome: R-HSA-391160 Signal regulatory protein family interactions 1 APLA006952-PA Reactome: R-HSA-73762 RNA Polymerase I Transcription Initiation 19 APLA000743-PA;APLA005702-PA;APLA003279-PA;APLA003046-PA;APLA002675-PA;APLA005703-PA;APLA001551-PA;APLA000879-PA;APLA010986-PA;APLA014037-PA;APLA013703-PA;APLA000630-PA;APLA003311-PA;APLA014136-PA;APLA001624-PA;APLA011270-PA;APLA009703-PA;APLA001596-PA;APLA009344-PA MetaCyc: PWY-5278 Sulfite oxidation III 1 APLA000768-PA Reactome: R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 14 APLA012406-PA;APLA003353-PA;APLA000365-PA;APLA009590-PA;APLA009662-PA;APLA004209-PA;APLA008808-PA;APLA006643-PA;APLA006644-PA;APLA009824-PA;APLA013848-PA;APLA009424-PA;APLA014443-PA;APLA014958-PA Reactome: R-HSA-418217 G beta:gamma signalling through PLC beta 1 APLA006554-PA Reactome: R-HSA-139853 Elevation of cytosolic Ca2+ levels 1 APLA003653-PA MetaCyc: PWY-7346 UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose) 1 APLA005458-PA Reactome: R-HSA-192456 Digestion of dietary lipid 2 APLA001794-PA;APLA003983-PA Reactome: R-HSA-171319 Telomere Extension By Telomerase 5 APLA014002-PA;APLA014004-PA;APLA004353-PA;APLA000688-PA;APLA012604-PA KEGG: 00720+1.1.1.42 Carbon fixation pathways in prokaryotes 1 APLA001137-PA MetaCyc: PWY-7426 Complex N-linked glycan biosynthesis (vertebrates) 4 APLA007125-PA;APLA014869-PA;APLA014868-PA;APLA012410-PA MetaCyc: PWY-5743 3-hydroxypropanoate cycle 8 APLA008850-PA;APLA002692-PA;APLA007201-PA;APLA010823-PA;APLA013496-PA;APLA013219-PA;APLA010822-PA;APLA014966-PA KEGG: 00052+2.7.1.1 Galactose metabolism 2 APLA001397-PA;APLA002389-PA KEGG: 00860+1.3.3.4 Porphyrin and chlorophyll metabolism 1 APLA001914-PA Reactome: R-HSA-6804754 Regulation of TP53 Expression 1 APLA008066-PA Reactome: R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 10 APLA004800-PA;APLA010039-PA;APLA012291-PA;APLA005856-PA;APLA004850-PA;APLA002395-PA;APLA000767-PA;APLA005249-PA;APLA002140-PA;APLA010464-PA Reactome: R-HSA-389357 CD28 dependent PI3K/Akt signaling 6 APLA011144-PA;APLA012421-PA;APLA013745-PA;APLA010399-PA;APLA014094-PA;APLA005545-PA MetaCyc: PWY-5941 Glycogen degradation II 4 APLA006822-PA;APLA004009-PA;APLA004011-PA;APLA006828-PA Reactome: R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 3 APLA011326-PA;APLA014272-PA;APLA002288-PA MetaCyc: PWY-7180 2-deoxy-alpha-D-ribose 1-phosphate degradation 1 APLA014461-PA KEGG: 00480+1.1.1.44 Glutathione metabolism 2 APLA012900-PA;APLA012905-PA KEGG: 00410+1.3.3.6 beta-Alanine metabolism 2 APLA013190-PA;APLA003250-PA MetaCyc: PWY-7733 3-hydroxyquinaldate biosynthesis 1 APLA005085-PA MetaCyc: PWY-5663 Erythro-tetrahydrobiopterin biosynthesis I 1 APLA006918-PA Reactome: R-HSA-6804760 Regulation of TP53 Activity through Methylation 4 APLA014272-PA;APLA003799-PA;APLA002288-PA;APLA008756-PA MetaCyc: PWY-6333 Acetaldehyde biosynthesis I 1 APLA001970-PA KEGG: 00670+1.5.1.3 One carbon pool by folate 1 APLA012570-PA Reactome: R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 2 APLA002140-PA;APLA014679-PA KEGG: 00430+1.13.11.20 Taurine and hypotaurine metabolism 1 APLA004739-PA Reactome: R-HSA-1475029 Reversible hydration of carbon dioxide 2 APLA014966-PA;APLA008850-PA KEGG: 00640+1.8.1.4 Propanoate metabolism 1 APLA003939-PA KEGG: 00330+3.5.3.1 Arginine and proline metabolism 1 APLA010889-PA KEGG: 00190+7.1.2.2 Oxidative phosphorylation 6 APLA015230-PA;APLA009120-PA;APLA002666-PA;APLA006976-PA;APLA006973-PA;APLA010311-PA Reactome: R-HSA-70221 Glycogen breakdown (glycogenolysis) 7 APLA012698-PA;APLA006828-PA;APLA003816-PA;APLA008533-PA;APLA004011-PA;APLA004009-PA;APLA006822-PA MetaCyc: PWY-7546 Diphthamide biosynthesis II (eukaryotes) 3 APLA012901-PA;APLA005402-PA;APLA009467-PA Reactome: R-HSA-165181 Inhibition of TSC complex formation by PKB 3 APLA009150-PA;APLA007496-PA;APLA007498-PA KEGG: 00030+4.1.2.13 Pentose phosphate pathway 2 APLA000565-PA;APLA000619-PA Reactome: R-HSA-390522 Striated Muscle Contraction 5 APLA011453-PA;APLA011452-PA;APLA005272-PA;APLA005271-PA;APLA005502-PA MetaCyc: PWY-7077 N-acetyl-D-galactosamine degradation 1 APLA000217-PA Reactome: R-HSA-202733 Cell surface interactions at the vascular wall 5 APLA003544-PA;APLA008495-PA;APLA002555-PA;APLA003678-PA;APLA013952-PA KEGG: 00280+6.4.1.3 Valine, leucine and isoleucine degradation 1 APLA007201-PA KEGG: 00400+2.6.1.5 Phenylalanine, tyrosine and tryptophan biosynthesis 1 APLA013125-PA Reactome: R-HSA-877300 Interferon gamma signaling 6 APLA005368-PA;APLA001323-PA;APLA007030-PA;APLA005365-PA;APLA003633-PA;APLA000549-PA MetaCyc: PWY-7802 N-end rule pathway II (prokaryotic) 1 APLA000926-PA Reactome: R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 115 APLA008770-PA;APLA013968-PA;APLA000903-PA;APLA011132-PA;APLA009810-PA;APLA001601-PA;APLA013711-PA;APLA006632-PA;APLA011528-PA;APLA011613-PA;APLA000810-PA;APLA006975-PA;APLA000126-PA;APLA008811-PA;APLA000270-PA;APLA009182-PA;APLA010460-PA;APLA004102-PA;APLA004504-PA;APLA000032-PA;APLA001635-PA;APLA009808-PA;APLA013236-PA;APLA013844-PA;APLA015248-PA;APLA015189-PA;APLA008705-PA;APLA004642-PA;APLA010503-PA;APLA000806-PA;APLA001089-PA;APLA013918-PA;APLA009042-PA;APLA010347-PA;APLA004089-PA;APLA014003-PA;APLA009985-PA;APLA008029-PA;APLA010995-PA;APLA002507-PA;APLA011273-PA;APLA001189-PA;APLA004277-PA;APLA006607-PA;APLA001313-PA;APLA005017-PA;APLA005262-PA;APLA015239-PA;APLA009827-PA;APLA009527-PA;APLA010644-PA;APLA003001-PA;APLA015028-PA;APLA013223-PA;APLA009944-PA;APLA010578-PA;APLA015291-PA;APLA013070-PA;APLA011678-PA;APLA005704-PA;APLA009482-PA;APLA008526-PA;APLA001679-PA;APLA008987-PA;APLA012554-PA;APLA011706-PA;APLA000773-PA;APLA008836-PA;APLA012713-PA;APLA007705-PA;APLA010457-PA;APLA011325-PA;APLA008686-PA;APLA008362-PA;APLA004494-PA;APLA011005-PA;APLA004524-PA;APLA011713-PA;APLA010466-PA;APLA000522-PA;APLA006851-PA;APLA007872-PA;APLA005604-PA;APLA005756-PA;APLA000168-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA003615-PA;APLA006943-PA;APLA007052-PA;APLA012176-PA;APLA009043-PA;APLA002288-PA;APLA010791-PA;APLA003531-PA;APLA013237-PA;APLA014016-PA;APLA003055-PA;APLA009207-PA;APLA004512-PA;APLA014272-PA;APLA002873-PA;APLA002428-PA;APLA002934-PA;APLA003532-PA;APLA013281-PA;APLA012477-PA;APLA012828-PA;APLA010574-PA;APLA012977-PA;APLA004218-PA;APLA012891-PA;APLA008524-PA;APLA000940-PA Reactome: R-HSA-5368286 Mitochondrial translation initiation 51 APLA010331-PA;APLA009248-PA;APLA011020-PA;APLA008421-PA;APLA005695-PA;APLA003598-PA;APLA006947-PA;APLA011305-PA;APLA001022-PA;APLA015036-PA;APLA012294-PA;APLA004314-PA;APLA002753-PA;APLA011712-PA;APLA007494-PA;APLA001936-PA;APLA012690-PA;APLA000197-PA;APLA015082-PA;APLA000426-PA;APLA009119-PA;APLA013466-PA;APLA002494-PA;APLA008023-PA;APLA014142-PA;APLA014874-PA;APLA000120-PA;APLA014334-PA;APLA013155-PA;APLA012546-PA;APLA014309-PA;APLA004449-PA;APLA013787-PA;APLA013883-PA;APLA011778-PA;APLA004983-PA;APLA005078-PA;APLA011113-PA;APLA000316-PA;APLA008576-PA;APLA005357-PA;APLA012699-PA;APLA002581-PA;APLA003061-PA;APLA008443-PA;APLA002686-PA;APLA011220-PA;APLA002854-PA;APLA006681-PA;APLA002636-PA;APLA008154-PA Reactome: R-HSA-5626467 RHO GTPases activate IQGAPs 21 APLA004383-PA;APLA004700-PA;APLA015416-PA;APLA010197-PA;APLA009417-PA;APLA010198-PA;APLA001953-PA;APLA002135-PA;APLA015031-PA;APLA013357-PA;APLA002551-PA;APLA010596-PA;APLA013359-PA;APLA014850-PA;APLA004850-PA;APLA007858-PA;APLA012338-PA;APLA014998-PA;APLA014048-PA;APLA010196-PA;APLA008446-PA KEGG: 00052+2.7.1.11 Galactose metabolism 2 APLA013705-PA;APLA013706-PA MetaCyc: PWY-8040 Ansatrienin biosynthesis 1 APLA014952-PA MetaCyc: PWY-5481 Pyruvate fermentation to (S)-lactate 2 APLA000736-PA;APLA000737-PA Reactome: R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 36 APLA006943-PA;APLA010995-PA;APLA010791-PA;APLA002288-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA012593-PA;APLA005719-PA;APLA002934-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA014016-PA;APLA006607-PA;APLA001313-PA;APLA002873-PA;APLA002428-PA;APLA014272-PA;APLA008987-PA;APLA011613-PA;APLA011706-PA;APLA006975-PA;APLA000810-PA;APLA008836-PA;APLA000126-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA008686-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA011713-PA;APLA010460-PA;APLA004504-PA KEGG: 05170+2.7.1.153 Human immunodeficiency virus 1 infection 1 APLA002528-PA KEGG: 00310+1.2.4.2 Lysine degradation 3 APLA011349-PA;APLA007913-PA;APLA003091-PA Reactome: R-HSA-9615710 Late endosomal microautophagy 8 APLA011952-PA;APLA007447-PA;APLA003608-PA;APLA014272-PA;APLA003018-PA;APLA005195-PA;APLA002288-PA;APLA008872-PA Reactome: R-HSA-9627069 Regulation of the apoptosome activity 5 APLA013736-PA;APLA002140-PA;APLA009642-PA;APLA009882-PA;APLA009072-PA KEGG: 00073+1.2.1.84 Cutin, suberine and wax biosynthesis 9 APLA000546-PA;APLA000545-PA;APLA001864-PA;APLA002536-PA;APLA000540-PA;APLA003949-PA;APLA000726-PA;APLA000704-PA;APLA000539-PA KEGG: 00350+2.6.1.5 Tyrosine metabolism 1 APLA013125-PA MetaCyc: PWY-7803 Trna splicing II 2 APLA000315-PA;APLA000369-PA Reactome: R-HSA-2395516 Electron transport from NADPH to Ferredoxin 3 APLA007957-PA;APLA002948-PA;APLA008939-PA Reactome: R-HSA-1222556 ROS and RNS production in phagocytes 20 APLA008016-PA;APLA015217-PA;APLA006357-PA;APLA013217-PA;APLA001263-PA;APLA008022-PA;APLA002666-PA;APLA006015-PA;APLA011554-PA;APLA003280-PA;APLA008019-PA;APLA000368-PA;APLA004385-PA;APLA007060-PA;APLA010311-PA;APLA011553-PA;APLA005327-PA;APLA000114-PA;APLA000056-PA;APLA008018-PA Reactome: R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes 3 APLA012204-PA;APLA005305-PA;APLA005245-PA Reactome: R-HSA-901042 Calnexin/calreticulin cycle 2 APLA007932-PA;APLA009488-PA MetaCyc: PWY-3801 Sucrose degradation II (sucrose synthase) 2 APLA014015-PA;APLA003021-PA Reactome: R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 3 APLA003259-PA;APLA007030-PA;APLA002988-PA Reactome: R-HSA-5694530 Cargo concentration in the ER 7 APLA003966-PA;APLA012581-PA;APLA007154-PA;APLA003964-PA;APLA008529-PA;APLA001000-PA;APLA010885-PA KEGG: 00010+1.1.1.1 Glycolysis / Gluconeogenesis 1 APLA001970-PA MetaCyc: PWY-5030 L-histidine degradation III 2 APLA005741-PA;APLA005730-PA Reactome: R-HSA-3232118 SUMOylation of transcription factors 1 APLA010286-PA MetaCyc: PWY-7979 Protein O-mannosylation III (mammals, core M3) 7 APLA007255-PA;APLA012979-PA;APLA013212-PA;APLA008830-PA;APLA008605-PA;APLA010474-PA;APLA007195-PA Reactome: R-HSA-6807004 Negative regulation of MET activity 8 APLA014546-PA;APLA009701-PA;APLA002186-PA;APLA014272-PA;APLA010445-PA;APLA000454-PA;APLA002288-PA;APLA005405-PA Reactome: R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 29 APLA003187-PA;APLA014520-PA;APLA001596-PA;APLA011795-PA;APLA009703-PA;APLA014999-PA;APLA003048-PA;APLA008108-PA;APLA006924-PA;APLA000547-PA;APLA001624-PA;APLA006899-PA;APLA008112-PA;APLA001551-PA;APLA000879-PA;APLA013703-PA;APLA010986-PA;APLA014037-PA;APLA009185-PA;APLA014024-PA;APLA000743-PA;APLA003842-PA;APLA015000-PA;APLA003279-PA;APLA005321-PA;APLA001456-PA;APLA002938-PA;APLA003046-PA;APLA002937-PA MetaCyc: PWY-7221 Guanosine ribonucleotides de novo biosynthesis 11 APLA003519-PA;APLA002995-PA;APLA009372-PA;APLA005391-PA;APLA015112-PA;APLA002558-PA;APLA005740-PA;APLA005738-PA;APLA005232-PA;APLA011621-PA;APLA000359-PA MetaCyc: PWY-6922 L-Ndelta-acetylornithine biosynthesis 7 APLA001395-PA;APLA007435-PA;APLA010889-PA;APLA007436-PA;APLA011969-PA;APLA006252-PA;APLA002148-PA Reactome: R-HSA-209560 NF-kB is activated and signals survival 2 APLA014272-PA;APLA002288-PA MetaCyc: PWY-5891 Menaquinol-11 biosynthesis 1 APLA015235-PA Reactome: R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 1 APLA008988-PA MetaCyc: PWY-6519 8-amino-7-oxononanoate biosynthesis I 3 APLA007857-PA;APLA002545-PA;APLA002072-PA KEGG: 00640+2.6.1.19 Propanoate metabolism 1 APLA003896-PA KEGG: 00630+4.2.1.3 Glyoxylate and dicarboxylate metabolism 1 APLA008464-PA Reactome: R-HSA-196025 Formation of annular gap junctions 3 APLA008767-PA;APLA001793-PA;APLA010150-PA Reactome: R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 3 APLA014272-PA;APLA000830-PA;APLA002288-PA Reactome: R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 19 APLA012408-PA;APLA012134-PA;APLA010657-PA;APLA005077-PA;APLA004806-PA;APLA009419-PA;APLA001606-PA;APLA006012-PA;APLA003771-PA;APLA004856-PA;APLA009959-PA;APLA003650-PA;APLA006682-PA;APLA013627-PA;APLA006575-PA;APLA014380-PA;APLA007415-PA;APLA002090-PA;APLA009415-PA MetaCyc: PWY-7833 Biosynthesis of Lewis epitopes (H. pylori) 3 APLA005473-PA;APLA002118-PA;APLA005472-PA Reactome: R-HSA-69541 Stabilization of p53 2 APLA014272-PA;APLA002288-PA KEGG: 00261+2.7.7.4 Monobactam biosynthesis 1 APLA000768-PA Reactome: R-HSA-901032 ER Quality Control Compartment (ERQC) 3 APLA002288-PA;APLA014272-PA;APLA011585-PA Reactome: R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 26 APLA001551-PA;APLA000879-PA;APLA010986-PA;APLA014037-PA;APLA013703-PA;APLA009185-PA;APLA014024-PA;APLA000743-PA;APLA003279-PA;APLA015000-PA;APLA003842-PA;APLA002938-PA;APLA003046-PA;APLA001456-PA;APLA002937-PA;APLA009703-PA;APLA014520-PA;APLA003187-PA;APLA001596-PA;APLA014999-PA;APLA008108-PA;APLA006924-PA;APLA000547-PA;APLA008112-PA;APLA001624-PA;APLA006899-PA MetaCyc: PWY-2161B Glutamate removal from folates 1 APLA007315-PA KEGG: 00380+1.8.1.4 Tryptophan metabolism 1 APLA003939-PA KEGG: 00280+2.3.3.10 Valine, leucine and isoleucine degradation 1 APLA007166-PA Reactome: R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 19 APLA007959-PA;APLA014850-PA;APLA014519-PA;APLA008446-PA;APLA014998-PA;APLA007858-PA;APLA000049-PA;APLA010596-PA;APLA013357-PA;APLA008961-PA;APLA009217-PA;APLA013359-PA;APLA005863-PA;APLA001953-PA;APLA014716-PA;APLA015031-PA;APLA015416-PA;APLA009349-PA;APLA009417-PA Reactome: R-HSA-392451 G beta:gamma signalling through PI3Kgamma 1 APLA013745-PA Reactome: R-HSA-165159 mTOR signalling 8 APLA002692-PA;APLA008732-PA;APLA009658-PA;APLA004140-PA;APLA009758-PA;APLA010301-PA;APLA005545-PA;APLA014094-PA KEGG: 00980+1.1.1.1 Metabolism of xenobiotics by cytochrome P450 1 APLA001970-PA MetaCyc: PWY-5537 Pyruvate fermentation to acetate V 5 APLA001878-PA;APLA002458-PA;APLA010449-PA;APLA014289-PA;APLA004846-PA MetaCyc: PWY-801 Homocysteine and cysteine interconversion 1 APLA014127-PA KEGG: 00970+6.1.1.7 Aminoacyl-tRNA biosynthesis 2 APLA007550-PA;APLA006969-PA Reactome: R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 33 APLA010347-PA;APLA005756-PA;APLA005719-PA;APLA012593-PA;APLA007463-PA;APLA006943-PA;APLA002288-PA;APLA010791-PA;APLA010995-PA;APLA014016-PA;APLA014272-PA;APLA002428-PA;APLA002873-PA;APLA001313-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA013968-PA;APLA005704-PA;APLA001601-PA;APLA008987-PA;APLA008836-PA;APLA000126-PA;APLA011706-PA;APLA006975-PA;APLA000810-PA;APLA010460-PA;APLA004504-PA;APLA013844-PA;APLA004494-PA;APLA015189-PA;APLA008686-PA;APLA011713-PA Reactome: R-HSA-499943 Interconversion of nucleotide di- and triphosphates 18 APLA000186-PA;APLA008494-PA;APLA001202-PA;APLA012574-PA;APLA014612-PA;APLA014549-PA;APLA002558-PA;APLA013156-PA;APLA008966-PA;APLA001267-PA;APLA015335-PA;APLA006751-PA;APLA002792-PA;APLA000359-PA;APLA010349-PA;APLA009372-PA;APLA013251-PA;APLA009142-PA MetaCyc: PWY-5265 Peptidoglycan biosynthesis II (staphylococci) 2 APLA002213-PA;APLA009515-PA Reactome: R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 5 APLA001514-PA;APLA001380-PA;APLA002675-PA;APLA008956-PA;APLA011837-PA Reactome: R-HSA-196807 Nicotinate metabolism 8 APLA011044-PA;APLA012508-PA;APLA001862-PA;APLA013222-PA;APLA001860-PA;APLA000440-PA;APLA014913-PA;APLA002192-PA Reactome: R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 3 APLA001633-PA;APLA003480-PA;APLA010601-PA MetaCyc: PWY-5737 (5R)-carbapenem carboxylate biosynthesis 3 APLA002148-PA;APLA011969-PA;APLA006252-PA MetaCyc: PWY-2781 Cis-zeatin biosynthesis 1 APLA013811-PA Reactome: R-HSA-4641265 Repression of WNT target genes 5 APLA009504-PA;APLA009193-PA;APLA009503-PA;APLA009499-PA;APLA011311-PA Reactome: R-HSA-2022854 Keratan sulfate biosynthesis 3 APLA000479-PA;APLA014804-PA;APLA002535-PA MetaCyc: PWY-7533 Gliotoxin biosynthesis 9 APLA000878-PA;APLA002827-PA;APLA002059-PA;APLA011104-PA;APLA011095-PA;APLA014577-PA;APLA011106-PA;APLA011092-PA;APLA011093-PA Reactome: R-HSA-381753 Olfactory Signaling Pathway 2 APLA006946-PA;APLA008263-PA Reactome: R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 19 APLA003193-PA;APLA003151-PA;APLA009424-PA;APLA014377-PA;APLA005141-PA;APLA014443-PA;APLA000884-PA;APLA014545-PA;APLA003353-PA;APLA008808-PA;APLA002832-PA;APLA001459-PA;APLA014958-PA;APLA005000-PA;APLA001541-PA;APLA012406-PA;APLA009590-PA;APLA009662-PA;APLA006643-PA MetaCyc: PWY-6664 Di-myo-inositol phosphate biosynthesis 1 APLA012083-PA MetaCyc: PWY-622 Starch biosynthesis 5 APLA001296-PA;APLA003655-PA;APLA001295-PA;APLA007993-PA;APLA014015-PA Reactome: R-HSA-8964046 VLDL clearance 3 APLA003678-PA;APLA002555-PA;APLA003544-PA MetaCyc: PWY-7909 Formaldehyde oxidation VII (THF pathway) 2 APLA005730-PA;APLA005741-PA KEGG: 00040+1.1.1.22 Pentose and glucuronate interconversions 1 APLA005458-PA MetaCyc: PWY-6012-1 Acyl carrier protein activation 1 APLA001971-PA KEGG: 04070+3.1.4.11 Phosphatidylinositol signaling system 5 APLA012536-PA;APLA014442-PA;APLA003808-PA;APLA006557-PA;APLA006554-PA KEGG: 00270+1.13.11.20 Cysteine and methionine metabolism 1 APLA004739-PA Reactome: R-HSA-3000157 Laminin interactions 8 APLA003085-PA;APLA011073-PA;APLA004085-PA;APLA003026-PA;APLA003082-PA;APLA003024-PA;APLA004087-PA;APLA003731-PA KEGG: 00052+2.7.1.6 Galactose metabolism 2 APLA014848-PA;APLA001443-PA MetaCyc: PWY-3881 Mannitol biosynthesis 1 APLA004325-PA KEGG: 00520+3.5.1.25 Amino sugar and nucleotide sugar metabolism 1 APLA000217-PA MetaCyc: PWY-7112 4-hydroxy-2-nonenal detoxification 4 APLA014577-PA;APLA004294-PA;APLA004293-PA;APLA004285-PA Reactome: R-HSA-3000178 ECM proteoglycans 6 APLA003082-PA;APLA009721-PA;APLA007157-PA;APLA003085-PA;APLA004085-PA;APLA004087-PA KEGG: 00531+3.2.1.50 Glycosaminoglycan degradation 1 APLA007458-PA Reactome: R-HSA-9619483 Activation of AMPK downstream of NMDARs 20 APLA009417-PA;APLA014601-PA;APLA010198-PA;APLA004383-PA;APLA015416-PA;APLA010197-PA;APLA015031-PA;APLA010535-PA;APLA001953-PA;APLA013359-PA;APLA013357-PA;APLA002551-PA;APLA010596-PA;APLA012338-PA;APLA007858-PA;APLA014998-PA;APLA008446-PA;APLA010196-PA;APLA014048-PA;APLA014850-PA MetaCyc: PWY-7766 Heme b biosynthesis IV (Gram-positive bacteria) 1 APLA008197-PA KEGG: 00710+5.3.1.6 Carbon fixation in photosynthetic organisms 1 APLA000025-PA Reactome: R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 21 APLA014037-PA;APLA010986-PA;APLA013813-PA;APLA013703-PA;APLA015384-PA;APLA000879-PA;APLA001551-PA;APLA014921-PA;APLA001194-PA;APLA002288-PA;APLA003046-PA;APLA008788-PA;APLA003279-PA;APLA003842-PA;APLA000743-PA;APLA014272-PA;APLA003196-PA;APLA009703-PA;APLA001596-PA;APLA014520-PA;APLA001624-PA MetaCyc: PWY-5078 L-isoleucine degradation II 2 APLA001970-PA;APLA006327-PA Reactome: R-HSA-1912408 Pre-NOTCH Transcription and Translation 11 APLA011927-PA;APLA008956-PA;APLA013701-PA;APLA014130-PA;APLA013702-PA;APLA011837-PA;APLA003047-PA;APLA009856-PA;APLA002675-PA;APLA001380-PA;APLA001514-PA MetaCyc: PWY-7445 Luteolin triglucuronide degradation 1 APLA014196-PA KEGG: 00190+3.6.1.1 Oxidative phosphorylation 2 APLA001349-PA;APLA008549-PA KEGG: 00270+4.2.1.22 Cysteine and methionine metabolism 1 APLA014127-PA KEGG: 00513+2.4.1.143 Various types of N-glycan biosynthesis 2 APLA007125-PA;APLA012410-PA Reactome: R-HSA-176412 Phosphorylation of the APC/C 8 APLA005264-PA;APLA000806-PA;APLA000940-PA;APLA011005-PA;APLA005017-PA;APLA014003-PA;APLA003055-PA;APLA007872-PA MetaCyc: PWY-6854 Ethylene biosynthesis III (microbes) 7 APLA014955-PA;APLA001069-PA;APLA001070-PA;APLA002967-PA;APLA001684-PA;APLA011061-PA;APLA014953-PA Reactome: R-HSA-186763 Downstream signal transduction 3 APLA009992-PA;APLA002486-PA;APLA015057-PA Reactome: R-HSA-2559580 Oxidative Stress Induced Senescence 8 APLA000162-PA;APLA004432-PA;APLA002288-PA;APLA002140-PA;APLA009856-PA;APLA014272-PA;APLA003690-PA;APLA010562-PA MetaCyc: PWY-7227 Adenosine deoxyribonucleotides de novo biosynthesis 5 APLA002995-PA;APLA000359-PA;APLA009372-PA;APLA012574-PA;APLA001267-PA Reactome: R-HSA-5654732 Negative regulation of FGFR3 signaling 3 APLA014272-PA;APLA002288-PA;APLA002140-PA KEGG: 00640+6.2.1.1 Propanoate metabolism 2 APLA006387-PA;APLA008135-PA Reactome: R-HSA-77108 Utilization of Ketone Bodies 1 APLA001074-PA Reactome: R-HSA-198323 AKT phosphorylates targets in the cytosol 4 APLA009255-PA;APLA007498-PA;APLA007496-PA;APLA004140-PA MetaCyc: PWY-7205 CMP phosphorylation 3 APLA002995-PA;APLA009372-PA;APLA000359-PA KEGG: 00240+2.7.4.6 Pyrimidine metabolism 3 APLA002995-PA;APLA009372-PA;APLA000359-PA Reactome: R-HSA-2871837 FCERI mediated NF-kB activation 36 APLA015028-PA;APLA013223-PA;APLA002934-PA;APLA012977-PA;APLA006607-PA;APLA002428-PA;APLA002873-PA;APLA014272-PA;APLA001313-PA;APLA014016-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA006943-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA;APLA005756-PA;APLA010347-PA;APLA011713-PA;APLA013745-PA;APLA008686-PA;APLA015189-PA;APLA013844-PA;APLA004494-PA;APLA004504-PA;APLA010460-PA;APLA000126-PA;APLA008836-PA;APLA006975-PA;APLA011706-PA;APLA000810-PA;APLA008987-PA;APLA001601-PA;APLA005704-PA;APLA013968-PA Reactome: R-HSA-427413 NoRC negatively regulates rRNA expression 22 APLA013703-PA;APLA014037-PA;APLA010986-PA;APLA008801-PA;APLA000879-PA;APLA005703-PA;APLA001551-PA;APLA003046-PA;APLA011133-PA;APLA003279-PA;APLA000743-PA;APLA008288-PA;APLA014515-PA;APLA005906-PA;APLA009344-PA;APLA001596-PA;APLA009703-PA;APLA001624-PA;APLA003311-PA;APLA000630-PA;APLA014136-PA;APLA001825-PA Reactome: R-HSA-156581 Methylation 2 APLA008908-PA;APLA010171-PA KEGG: 00680+3.1.2.12 Methane metabolism 1 APLA008280-PA MetaCyc: PWY-6537 4-aminobutanoate degradation II 1 APLA003896-PA Reactome: R-HSA-5389840 Mitochondrial translation elongation 52 APLA001936-PA;APLA007494-PA;APLA011712-PA;APLA009740-PA;APLA004314-PA;APLA002753-PA;APLA012294-PA;APLA009119-PA;APLA000426-PA;APLA015082-PA;APLA000197-PA;APLA011020-PA;APLA009248-PA;APLA010331-PA;APLA003429-PA;APLA015036-PA;APLA001022-PA;APLA011305-PA;APLA003598-PA;APLA006947-PA;APLA005695-PA;APLA008421-PA;APLA002686-PA;APLA008443-PA;APLA002581-PA;APLA012699-PA;APLA003061-PA;APLA005357-PA;APLA008154-PA;APLA002636-PA;APLA006681-PA;APLA002854-PA;APLA008652-PA;APLA011220-PA;APLA009000-PA;APLA000120-PA;APLA014874-PA;APLA002494-PA;APLA013466-PA;APLA005078-PA;APLA011113-PA;APLA000316-PA;APLA008576-PA;APLA004983-PA;APLA011778-PA;APLA013883-PA;APLA013787-PA;APLA014309-PA;APLA012546-PA;APLA004449-PA;APLA013155-PA;APLA014334-PA KEGG: 00270+2.6.1.1 Cysteine and methionine metabolism 2 APLA012983-PA;APLA012145-PA Reactome: R-HSA-111457 Release of apoptotic factors from the mitochondria 2 APLA013736-PA;APLA009642-PA MetaCyc: PWY-6981 Chitin biosynthesis 1 APLA014015-PA KEGG: 00983+1.17.4.1 Drug metabolism - other enzymes 2 APLA012574-PA;APLA001267-PA Reactome: R-HSA-1482925 Acyl chain remodelling of PG 4 APLA009079-PA;APLA004469-PA;APLA005748-PA;APLA005749-PA KEGG: 00513+2.4.1.258 Various types of N-glycan biosynthesis 1 APLA014717-PA Reactome: R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 3 APLA014841-PA;APLA001691-PA;APLA003680-PA MetaCyc: PWY-1042 Glycolysis IV (plant cytosol) 15 APLA010500-PA;APLA010497-PA;APLA015268-PA;APLA003817-PA;APLA007679-PA;APLA000619-PA;APLA003818-PA;APLA013706-PA;APLA000565-PA;APLA007919-PA;APLA007488-PA;APLA010499-PA;APLA000476-PA;APLA013705-PA;APLA006547-PA Reactome: R-HSA-5632681 Ligand-receptor interactions 1 APLA009411-PA Reactome: R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 21 APLA014999-PA;APLA014520-PA;APLA011795-PA;APLA003187-PA;APLA008108-PA;APLA003048-PA;APLA000547-PA;APLA006924-PA;APLA006899-PA;APLA008112-PA;APLA001551-PA;APLA013703-PA;APLA014037-PA;APLA015000-PA;APLA003842-PA;APLA009185-PA;APLA014024-PA;APLA000743-PA;APLA001456-PA;APLA005321-PA;APLA003046-PA Reactome: R-HSA-5685938 HDR through Single Strand Annealing (SSA) 19 APLA014958-PA;APLA005000-PA;APLA002832-PA;APLA001459-PA;APLA006643-PA;APLA009662-PA;APLA001541-PA;APLA012406-PA;APLA000884-PA;APLA014545-PA;APLA003151-PA;APLA009424-PA;APLA014377-PA;APLA003193-PA;APLA014443-PA;APLA006346-PA;APLA005141-PA;APLA008808-PA;APLA003353-PA KEGG: 00350+3.7.1.2 Tyrosine metabolism 1 APLA012222-PA MetaCyc: PWY-7411 Phosphatidate biosynthesis (yeast) 7 APLA002667-PA;APLA012686-PA;APLA009816-PA;APLA000543-PA;APLA008027-PA;APLA014471-PA;APLA004147-PA KEGG: 00620+1.2.4.1 Pyruvate metabolism 2 APLA005998-PA;APLA001487-PA MetaCyc: PWY-7858 (5Z)-dodecenoate biosynthesis II 5 APLA003250-PA;APLA013190-PA;APLA007857-PA;APLA002072-PA;APLA002545-PA Reactome: R-HSA-198753 ERK/MAPK targets 1 APLA002140-PA Reactome: R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 23 APLA001290-PA;APLA011447-PA;APLA015058-PA;APLA001717-PA;APLA006060-PA;APLA004137-PA;APLA002937-PA;APLA002444-PA;APLA002938-PA;APLA010643-PA;APLA003482-PA;APLA003076-PA;APLA001716-PA;APLA002878-PA;APLA005565-PA;APLA009708-PA;APLA000427-PA;APLA004737-PA;APLA006974-PA;APLA000426-PA;APLA005231-PA;APLA005336-PA;APLA011986-PA MetaCyc: PWY-7401 Crotonate fermentation (to acetate and cyclohexane carboxylate) 4 APLA000468-PA;APLA006174-PA;APLA006178-PA;APLA014896-PA Reactome: R-HSA-199220 Vitamin B5 (pantothenate) metabolism 5 APLA007857-PA;APLA001971-PA;APLA002547-PA;APLA002545-PA;APLA002072-PA Reactome: R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 2 APLA014258-PA;APLA002552-PA KEGG: 00230+6.3.5.3 Purine metabolism 1 APLA012530-PA MetaCyc: PWY-6113 Superpathway of mycolate biosynthesis 3 APLA007857-PA;APLA002072-PA;APLA002545-PA MetaCyc: PWY-7396 Butanol and isobutanol biosynthesis (engineered) 1 APLA001970-PA KEGG: 00510+2.4.1.68 N-Glycan biosynthesis 2 APLA014868-PA;APLA014869-PA KEGG: 00900+1.1.1.34 Terpenoid backbone biosynthesis 1 APLA012425-PA KEGG: 04926+2.7.11.1 Relaxin signaling pathway 35 APLA008151-PA;APLA012070-PA;APLA011336-PA;APLA013745-PA;APLA011405-PA;APLA011480-PA;APLA003517-PA;APLA005251-PA;APLA009103-PA;APLA015343-PA;APLA008080-PA;APLA001451-PA;APLA003690-PA;APLA001541-PA;APLA014655-PA;APLA010535-PA;APLA010570-PA;APLA006659-PA;APLA002693-PA;APLA009561-PA;APLA003559-PA;APLA014007-PA;APLA012309-PA;APLA014094-PA;APLA000202-PA;APLA009255-PA;APLA002024-PA;APLA014432-PA;APLA004865-PA;APLA006809-PA;APLA005222-PA;APLA005545-PA;APLA005614-PA;APLA005789-PA;APLA006656-PA Reactome: R-HSA-3249367 STAT6-mediated induction of chemokines 1 APLA007487-PA MetaCyc: PWY-5892 Menaquinol-12 biosynthesis 1 APLA015235-PA Reactome: R-HSA-168638 NOD1/2 Signaling Pathway 3 APLA002288-PA;APLA014272-PA;APLA005606-PA Reactome: R-HSA-3232142 SUMOylation of ubiquitinylation proteins 16 APLA004137-PA;APLA006060-PA;APLA015058-PA;APLA011447-PA;APLA001290-PA;APLA003482-PA;APLA010643-PA;APLA002444-PA;APLA000427-PA;APLA009708-PA;APLA005565-PA;APLA002878-PA;APLA011986-PA;APLA000426-PA;APLA005336-PA;APLA005231-PA Reactome: R-HSA-8853884 Transcriptional Regulation by VENTX 9 APLA003055-PA;APLA007872-PA;APLA005264-PA;APLA000940-PA;APLA000806-PA;APLA011005-PA;APLA005017-PA;APLA014003-PA;APLA009856-PA MetaCyc: PWY-5386 Methylglyoxal degradation I 3 APLA004537-PA;APLA008758-PA;APLA004539-PA Reactome: R-HSA-6791462 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 1 APLA008988-PA Reactome: R-HSA-3322077 Glycogen synthesis 5 APLA002288-PA;APLA003021-PA;APLA014272-PA;APLA000677-PA;APLA003655-PA Reactome: R-HSA-975634 Retinoid metabolism and transport 11 APLA011087-PA;APLA003544-PA;APLA011893-PA;APLA003678-PA;APLA002555-PA;APLA013952-PA;APLA011894-PA;APLA011086-PA;APLA011085-PA;APLA001975-PA;APLA000730-PA KEGG: 00511+3.2.1.23 Other glycan degradation 5 APLA005795-PA;APLA001673-PA;APLA004972-PA;APLA001817-PA;APLA004969-PA Reactome: R-HSA-180024 DARPP-32 events 5 APLA003348-PA;APLA009113-PA;APLA003229-PA;APLA010182-PA;APLA003228-PA KEGG: 00680+5.4.2.11 Methane metabolism 2 APLA004744-PA;APLA006779-PA Reactome: R-HSA-196836 Vitamin C (ascorbate) metabolism 1 APLA014577-PA Reactome: R-HSA-380259 Loss of Nlp from mitotic centrosomes 8 APLA015228-PA;APLA015241-PA;APLA004323-PA;APLA014355-PA;APLA008326-PA;APLA008995-PA;APLA014791-PA;APLA003210-PA MetaCyc: PWY-7198 Pyrimidine deoxyribonucleotides de novo biosynthesis IV 9 APLA008494-PA;APLA012574-PA;APLA001267-PA;APLA001202-PA;APLA000359-PA;APLA001305-PA;APLA009372-PA;APLA009142-PA;APLA002995-PA KEGG: 00620+4.2.1.2 Pyruvate metabolism 1 APLA003089-PA Reactome: R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 5 APLA008956-PA;APLA011837-PA;APLA001514-PA;APLA001380-PA;APLA002675-PA Reactome: R-HSA-5696394 DNA Damage Recognition in GG-NER 13 APLA002124-PA;APLA003700-PA;APLA014272-PA;APLA002404-PA;APLA011412-PA;APLA006584-PA;APLA000830-PA;APLA002288-PA;APLA004572-PA;APLA001661-PA;APLA000551-PA;APLA004465-PA;APLA000829-PA KEGG: 00330+2.6.1.13 Arginine and proline metabolism 1 APLA001395-PA Reactome: R-HSA-4720475 Defective ALG3 causes ALG3-CDG (CDG-1d) 1 APLA014717-PA Reactome: R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 13 APLA014272-PA;APLA015241-PA;APLA002641-PA;APLA004323-PA;APLA006607-PA;APLA015228-PA;APLA008995-PA;APLA008326-PA;APLA014355-PA;APLA002288-PA;APLA014791-PA;APLA003210-PA;APLA002934-PA KEGG: 00680+6.2.1.1 Methane metabolism 2 APLA008135-PA;APLA006387-PA KEGG: 00030+3.1.3.11 Pentose phosphate pathway 1 APLA009512-PA Reactome: R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway 4 APLA012410-PA;APLA014868-PA;APLA014869-PA;APLA007125-PA KEGG: 00603+3.2.1.52 Glycosphingolipid biosynthesis - globo and isoglobo series 6 APLA010555-PA;APLA003010-PA;APLA012599-PA;APLA001187-PA;APLA006026-PA;APLA002044-PA KEGG: 00532+2.4.2.26 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1 APLA008128-PA MetaCyc: PWY-7179 Purine deoxyribonucleosides degradation I 5 APLA015153-PA;APLA000262-PA;APLA006728-PA;APLA013738-PA;APLA006726-PA Reactome: R-HSA-5658034 HHAT G278V abrogates palmitoylation of Hh-Np 1 APLA009411-PA MetaCyc: PWY-7841 Neolacto-series glycosphingolipids biosynthesis 1 APLA012402-PA KEGG: 00860+4.1.1.37 Porphyrin and chlorophyll metabolism 1 APLA008197-PA Reactome: R-HSA-6791461 RPIA deficiency: failed conversion of RU5P to R5P 1 APLA000025-PA KEGG: 00030+2.2.1.2 Pentose phosphate pathway 1 APLA008988-PA Reactome: R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome 8 APLA014791-PA;APLA003210-PA;APLA004323-PA;APLA015241-PA;APLA015228-PA;APLA008995-PA;APLA008326-PA;APLA014355-PA Reactome: R-HSA-112382 Formation of RNA Pol II elongation complex 36 APLA000547-PA;APLA007972-PA;APLA001624-PA;APLA006899-PA;APLA008112-PA;APLA003187-PA;APLA008984-PA;APLA008108-PA;APLA015000-PA;APLA008519-PA;APLA000743-PA;APLA014024-PA;APLA001456-PA;APLA009107-PA;APLA002938-PA;APLA001551-PA;APLA013703-PA;APLA009092-PA;APLA006924-PA;APLA002009-PA;APLA014999-PA;APLA011795-PA;APLA001596-PA;APLA014520-PA;APLA009703-PA;APLA003048-PA;APLA005278-PA;APLA003842-PA;APLA003279-PA;APLA009185-PA;APLA002937-PA;APLA005321-PA;APLA003046-PA;APLA000879-PA;APLA014037-PA;APLA010986-PA MetaCyc: PWY-7338 10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast) 2 APLA013190-PA;APLA003250-PA MetaCyc: PWY-4381 Fatty acid biosynthesis initiation (bacteria and plants) 7 APLA007857-PA;APLA010822-PA;APLA002545-PA;APLA002072-PA;APLA010823-PA;APLA013496-PA;APLA013219-PA KEGG: 00510+2.4.1.256 N-Glycan biosynthesis 1 APLA006738-PA Reactome: R-HSA-8949664 Processing of SMDT1 7 APLA000572-PA;APLA009154-PA;APLA002880-PA;APLA013239-PA;APLA001670-PA;APLA002881-PA;APLA008485-PA KEGG: 00240+2.7.4.14 Pyrimidine metabolism 1 APLA014549-PA Reactome: R-HSA-8854518 AURKA Activation by TPX2 9 APLA015228-PA;APLA015241-PA;APLA001520-PA;APLA004323-PA;APLA014355-PA;APLA008326-PA;APLA008995-PA;APLA014791-PA;APLA003210-PA KEGG: 00561+3.1.1.3 Glycerolipid metabolism 2 APLA003983-PA;APLA001794-PA Reactome: R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 16 APLA003482-PA;APLA010643-PA;APLA002444-PA;APLA011447-PA;APLA001290-PA;APLA006060-PA;APLA004137-PA;APLA015058-PA;APLA011986-PA;APLA005231-PA;APLA000426-PA;APLA005336-PA;APLA005565-PA;APLA002878-PA;APLA000427-PA;APLA009708-PA KEGG: 00790+4.2.1.96 Folate biosynthesis 1 APLA014138-PA KEGG: 00240+2.4.2.10 Pyrimidine metabolism 1 APLA004501-PA MetaCyc: PWY-6554 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 2 APLA003180-PA;APLA014683-PA MetaCyc: PWY-6583 Pyruvate fermentation to butanol I 4 APLA000468-PA;APLA006174-PA;APLA006178-PA;APLA014896-PA MetaCyc: PWY-7111 Pyruvate fermentation to isobutanol (engineered) 1 APLA001970-PA Reactome: R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 34 APLA008686-PA;APLA004494-PA;APLA013844-PA;APLA015189-PA;APLA011713-PA;APLA004504-PA;APLA010460-PA;APLA008987-PA;APLA008836-PA;APLA000126-PA;APLA006975-PA;APLA011706-PA;APLA000810-PA;APLA005704-PA;APLA013968-PA;APLA001601-PA;APLA012977-PA;APLA013223-PA;APLA015028-PA;APLA014016-PA;APLA006607-PA;APLA002873-PA;APLA002428-PA;APLA014272-PA;APLA001313-PA;APLA006943-PA;APLA010791-PA;APLA002288-PA;APLA010995-PA;APLA005756-PA;APLA010347-PA;APLA007463-PA;APLA005719-PA;APLA012593-PA Reactome: R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters 1 APLA005523-PA MetaCyc: PWY-7820 Teichuronic acid biosynthesis (B. subtilis 168) 1 APLA005458-PA Reactome: R-HSA-6798695 Neutrophil degranulation 94 APLA014472-PA;APLA000262-PA;APLA012076-PA;APLA004183-PA;APLA005953-PA;APLA013738-PA;APLA010578-PA;APLA001817-PA;APLA007551-PA;APLA004011-PA;APLA004173-PA;APLA004130-PA;APLA005913-PA;APLA012135-PA;APLA004172-PA;APLA004175-PA;APLA004504-PA;APLA010460-PA;APLA002186-PA;APLA002360-PA;APLA012418-PA;APLA012736-PA;APLA001089-PA;APLA004171-PA;APLA004174-PA;APLA004182-PA;APLA013813-PA;APLA004588-PA;APLA001263-PA;APLA000366-PA;APLA007487-PA;APLA014015-PA;APLA001416-PA;APLA007938-PA;APLA003519-PA;APLA012887-PA;APLA012114-PA;APLA005795-PA;APLA010513-PA;APLA013714-PA;APLA000730-PA;APLA006339-PA;APLA008961-PA;APLA002428-PA;APLA002873-PA;APLA009419-PA;APLA006443-PA;APLA005405-PA;APLA001673-PA;APLA004273-PA;APLA009588-PA;APLA010406-PA;APLA000056-PA;APLA000708-PA;APLA004184-PA;APLA011572-PA;APLA010791-PA;APLA007315-PA;APLA012605-PA;APLA010682-PA;APLA003120-PA;APLA007134-PA;APLA000287-PA;APLA003531-PA;APLA015327-PA;APLA001878-PA;APLA012840-PA;APLA012039-PA;APLA006726-PA;APLA008790-PA;APLA002965-PA;APLA006728-PA;APLA003566-PA;APLA003237-PA;APLA005501-PA;APLA003156-PA;APLA006341-PA;APLA004009-PA;APLA015153-PA;APLA008561-PA;APLA005537-PA;APLA008686-PA;APLA014461-PA;APLA000186-PA;APLA009349-PA;APLA010445-PA;APLA010301-PA;APLA014914-PA;APLA009882-PA;APLA001292-PA;APLA010313-PA;APLA011706-PA;APLA004582-PA;APLA014593-PA Reactome: R-HSA-8948747 Regulation of PTEN localization 3 APLA002288-PA;APLA014272-PA;APLA001194-PA KEGG: 00630+1.1.1.37 Glyoxylate and dicarboxylate metabolism 3 APLA000684-PA;APLA005378-PA;APLA015456-PA MetaCyc: PWY-6536 4-aminobutanoate degradation III 1 APLA003896-PA Reactome: R-HSA-2161541 Abacavir metabolism 1 APLA002558-PA MetaCyc: PWY-6799 Fatty acid biosynthesis initiation (plant mitochondria) 3 APLA002072-PA;APLA002545-PA;APLA007857-PA Reactome: R-HSA-2467813 Separation of Sister Chromatids 84 APLA001313-PA;APLA013357-PA;APLA014048-PA;APLA010196-PA;APLA013223-PA;APLA015028-PA;APLA005017-PA;APLA014772-PA;APLA014850-PA;APLA010347-PA;APLA010995-PA;APLA014003-PA;APLA004504-PA;APLA010460-PA;APLA013359-PA;APLA002551-PA;APLA010596-PA;APLA007552-PA;APLA000427-PA;APLA001351-PA;APLA000806-PA;APLA001644-PA;APLA013844-PA;APLA015189-PA;APLA011986-PA;APLA010198-PA;APLA001601-PA;APLA010197-PA;APLA013968-PA;APLA015416-PA;APLA006975-PA;APLA000810-PA;APLA000126-PA;APLA015031-PA;APLA013547-PA;APLA014272-PA;APLA002428-PA;APLA002873-PA;APLA008230-PA;APLA014016-PA;APLA003055-PA;APLA008446-PA;APLA012338-PA;APLA005264-PA;APLA007858-PA;APLA000940-PA;APLA003480-PA;APLA012977-PA;APLA007463-PA;APLA009417-PA;APLA012593-PA;APLA005719-PA;APLA015058-PA;APLA005756-PA;APLA007872-PA;APLA004639-PA;APLA002883-PA;APLA002288-PA;APLA010791-PA;APLA010643-PA;APLA001953-PA;APLA006943-PA;APLA014679-PA;APLA001633-PA;APLA002856-PA;APLA005242-PA;APLA011005-PA;APLA002909-PA;APLA001683-PA;APLA011713-PA;APLA014998-PA;APLA000426-PA;APLA002859-PA;APLA008686-PA;APLA004494-PA;APLA009660-PA;APLA005704-PA;APLA004383-PA;APLA011706-PA;APLA014307-PA;APLA008836-PA;APLA002135-PA;APLA008987-PA;APLA001833-PA MetaCyc: PWY-6146 Methanobacterium thermoautotrophicum biosynthetic metabolism 1 APLA013385-PA Reactome: R-HSA-1266695 Interleukin-7 signaling 1 APLA012421-PA Reactome: R-HSA-373080 Class B/2 (Secretin family receptors) 23 APLA009723-PA;APLA011062-PA;APLA004452-PA;APLA007530-PA;APLA011586-PA;APLA009411-PA;APLA004909-PA;APLA013820-PA;APLA001157-PA;APLA004752-PA;APLA009726-PA;APLA001145-PA;APLA002849-PA;APLA009730-PA;APLA010595-PA;APLA009729-PA;APLA007531-PA;APLA009724-PA;APLA009727-PA;APLA012266-PA;APLA015399-PA;APLA001158-PA;APLA009728-PA Reactome: R-HSA-211945 Phase I - Functionalization of compounds 1 APLA011394-PA KEGG: 00730+3.1.3.2 Thiamine metabolism 1 APLA000700-PA Reactome: R-HSA-418594 G alpha (i) signalling events 23 APLA003037-PA;APLA013630-PA;APLA003039-PA;APLA015208-PA;APLA010647-PA;APLA001129-PA;APLA008313-PA;APLA000823-PA;APLA014278-PA;APLA013400-PA;APLA005274-PA;APLA011250-PA;APLA007417-PA;APLA007416-PA;APLA015481-PA;APLA004098-PA;APLA003536-PA;APLA005862-PA;APLA001168-PA;APLA005245-PA;APLA013772-PA;APLA001768-PA;APLA001432-PA KEGG: 00280+4.2.1.17+1.1.1.35 Valine, leucine and isoleucine degradation 4 APLA014896-PA;APLA006178-PA;APLA006174-PA;APLA000468-PA Reactome: R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 3 APLA001194-PA;APLA002288-PA;APLA014272-PA KEGG: 00592+1.3.3.6 alpha-Linolenic acid metabolism 2 APLA003250-PA;APLA013190-PA Reactome: R-HSA-8941856 RUNX3 regulates NOTCH signaling 5 APLA008956-PA;APLA011837-PA;APLA001514-PA;APLA001380-PA;APLA002675-PA Reactome: R-HSA-111471 Apoptotic factor-mediated response 1 APLA015204-PA Reactome: R-HSA-427975 Proton/oligopeptide cotransporters 2 APLA004082-PA;APLA004081-PA Reactome: R-HSA-2024096 HS-GAG degradation 13 APLA011086-PA;APLA011894-PA;APLA011893-PA;APLA013952-PA;APLA000287-PA;APLA005795-PA;APLA011087-PA;APLA001817-PA;APLA008323-PA;APLA011085-PA;APLA007458-PA;APLA009742-PA;APLA000708-PA Reactome: R-HSA-3214858 RMTs methylate histone arginines 13 APLA009234-PA;APLA009481-PA;APLA014534-PA;APLA003922-PA;APLA014542-PA;APLA006474-PA;APLA002907-PA;APLA003799-PA;APLA006699-PA;APLA003680-PA;APLA003782-PA;APLA008243-PA;APLA011309-PA Reactome: R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) 24 APLA014998-PA;APLA007858-PA;APLA012338-PA;APLA008446-PA;APLA010196-PA;APLA014048-PA;APLA014850-PA;APLA013359-PA;APLA006345-PA;APLA010596-PA;APLA002551-PA;APLA013357-PA;APLA015031-PA;APLA003210-PA;APLA014536-PA;APLA001953-PA;APLA015241-PA;APLA009417-PA;APLA015228-PA;APLA010198-PA;APLA015416-PA;APLA004453-PA;APLA004383-PA;APLA010197-PA KEGG: 00020+4.1.1.32 Citrate cycle (TCA cycle) 1 APLA013213-PA Reactome: R-HSA-6798163 Choline catabolism 42 APLA013078-PA;APLA013075-PA;APLA008742-PA;APLA014492-PA;APLA014423-PA;APLA008862-PA;APLA013073-PA;APLA013076-PA;APLA004652-PA;APLA008746-PA;APLA008748-PA;APLA004655-PA;APLA000963-PA;APLA004123-PA;APLA009452-PA;APLA013753-PA;APLA013752-PA;APLA013074-PA;APLA004653-PA;APLA008747-PA;APLA007102-PA;APLA013751-PA;APLA013750-PA;APLA008741-PA;APLA007034-PA;APLA013754-PA;APLA013079-PA;APLA001014-PA;APLA007612-PA;APLA007172-PA;APLA001015-PA;APLA008743-PA;APLA004124-PA;APLA008745-PA;APLA015095-PA;APLA013080-PA;APLA015417-PA;APLA008744-PA;APLA015180-PA;APLA004656-PA;APLA015182-PA;APLA000638-PA Reactome: R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 15 APLA008283-PA;APLA013151-PA;APLA001840-PA;APLA005000-PA;APLA014841-PA;APLA000884-PA;APLA014545-PA;APLA010387-PA;APLA001691-PA;APLA002790-PA;APLA001459-PA;APLA002832-PA;APLA003193-PA;APLA005141-PA;APLA006016-PA Reactome: R-HSA-5620912 Anchoring of the basal body to the plasma membrane 11 APLA003210-PA;APLA008463-PA;APLA014791-PA;APLA014355-PA;APLA008326-PA;APLA000757-PA;APLA008995-PA;APLA015228-PA;APLA011364-PA;APLA004323-PA;APLA015241-PA KEGG: 00670+6.3.4.3 One carbon pool by folate 1 APLA005730-PA KEGG: 00520+2.7.7.9 Amino sugar and nucleotide sugar metabolism 1 APLA003021-PA MetaCyc: PWY-7187 Pyrimidine deoxyribonucleotides de novo biosynthesis II 8 APLA009849-PA;APLA009005-PA;APLA002995-PA;APLA009372-PA;APLA009142-PA;APLA008494-PA;APLA001202-PA;APLA000359-PA KEGG: 00230+2.7.1.25 Purine metabolism 1 APLA000768-PA KEGG: 00970+6.1.1.14 Aminoacyl-tRNA biosynthesis 1 APLA008083-PA KEGG: 00240+3.1.3.5 Pyrimidine metabolism 1 APLA002282-PA Reactome: R-HSA-196819 Vitamin B1 (thiamin) metabolism 3 APLA010134-PA;APLA013341-PA;APLA005503-PA MetaCyc: PWY-6733 Sporopollenin precursors biosynthesis 9 APLA000546-PA;APLA000540-PA;APLA000545-PA;APLA002536-PA;APLA001864-PA;APLA003949-PA;APLA000704-PA;APLA000539-PA;APLA000726-PA KEGG: 00053+1.13.99.1 Ascorbate and aldarate metabolism 1 APLA006233-PA KEGG: 00513+3.2.1.52 Various types of N-glycan biosynthesis 6 APLA010555-PA;APLA003010-PA;APLA002044-PA;APLA006026-PA;APLA012599-PA;APLA001187-PA Reactome: R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 17 APLA008283-PA;APLA002288-PA;APLA005000-PA;APLA001459-PA;APLA002832-PA;APLA013151-PA;APLA011035-PA;APLA010387-PA;APLA014545-PA;APLA000884-PA;APLA014841-PA;APLA006016-PA;APLA005141-PA;APLA003193-PA;APLA014272-PA;APLA001691-PA;APLA002790-PA KEGG: 00020+1.3.5.1 Citrate cycle (TCA cycle) 5 APLA013330-PA;APLA000357-PA;APLA006254-PA;APLA003262-PA;APLA015489-PA MetaCyc: PWY-2301 Myo-inositol biosynthesis 3 APLA008242-PA;APLA012083-PA;APLA002096-PA Reactome: R-HSA-3371568 Attenuation phase 2 APLA001514-PA;APLA011837-PA