Accession_ID	Pathway_Count	Pathway_IDs	Pathway_Names
XP_053952512.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053967407.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053949286.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053947708.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053964285.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_053953301.1	11	Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-383280;Reactome: R-HSA-381340;Reactome: R-HSA-1368108;Reactome: R-HSA-400206;Reactome: R-HSA-9018519;Reactome: R-HSA-212436;Reactome: R-HSA-400253;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082	"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"Nuclear Receptor transcription pathway";"Transcriptional regulation of white adipocyte differentiation";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Regulation of lipid metabolism by PPARalpha";"Estrogen-dependent gene expression";"Generic Transcription Pathway";"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression"
XP_053953414.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053949991.1	5	Reactome: R-HSA-5674400;Reactome: R-HSA-1257604;Reactome: R-HSA-389357;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757	"Constitutive Signaling by AKT1 E17K in Cancer";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation"
XP_053967886.1	4	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053965388.1	3	Reactome: R-HSA-390471;Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Association of TriC/CCT with target proteins during biosynthesis";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053964329.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-380284	"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_053958213.1	2	Reactome: R-HSA-5663220;Reactome: R-HSA-376176	"RHO GTPases Activate Formins";"Signaling by ROBO receptors"
XP_053962791.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_053946857.1	3	KEGG: 00790+4.2.1.96;MetaCyc: PWY-7158;MetaCyc: PWY-8099	"Folate biosynthesis";"L-phenylalanine degradation V";"Tetrahydropteridine recycling"
XP_053945849.1	5	Reactome: R-HSA-4420097;KEGG: 04150+2.7.11.24;Reactome: R-HSA-168638;Reactome: R-HSA-376172;Reactome: R-HSA-171007	"VEGFA-VEGFR2 Pathway";"mTOR signaling pathway";"NOD1/2 Signaling Pathway";"DSCAM interactions";"p38MAPK events"
XP_053957229.1	3	KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348	"Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition"
XP_053945507.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053967454.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053970060.1	7	MetaCyc: PWY-6824;MetaCyc: PWY-5469;MetaCyc: PWY-5466;MetaCyc: PWY-7214;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461;MetaCyc: PWY-7445	"Justicidin B biosynthesis";"Sesamin biosynthesis";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Phenylpropanoid biosynthesis";"Betanidin degradation";"Luteolin triglucuronide degradation"
XP_053969305.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053946978.1	4	Reactome: R-HSA-210991;Reactome: R-HSA-71240;Reactome: R-HSA-352230;Reactome: R-HSA-5660862	"Basigin interactions";"Tryptophan catabolism";"Amino acid transport across the plasma membrane";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)"
XP_053951842.1	9	Reactome: R-HSA-114608;Reactome: R-HSA-6802946;Reactome: R-HSA-9649948;Reactome: R-HSA-6802948;Reactome: R-HSA-5674135;Reactome: R-HSA-6798695;Reactome: R-HSA-6802952;Reactome: R-HSA-445355;Reactome: R-HSA-6802955	"Platelet degranulation";"Signaling by moderate kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Signaling by high-kinase activity BRAF mutants";"MAP2K and MAPK activation";"Neutrophil degranulation";"Signaling by BRAF and RAF fusions";"Smooth Muscle Contraction";"Paradoxical activation of RAF signaling by kinase inactive BRAF"
XP_053960917.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_053964098.1	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
XP_053945664.1	4	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"DARPP-32 events"
XP_053955972.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_053970172.1	8	Reactome: R-HSA-1989781;MetaCyc: PWY-6174;MetaCyc: PWY-7524;MetaCyc: PWY-7391;Reactome: R-HSA-2426168;KEGG: 00900+1.1.1.34;Reactome: R-HSA-191273;MetaCyc: PWY-922	"PPARA activates gene expression";"Mevalonate pathway II (archaea)";"Mevalonate pathway III (archaea)";"Isoprene biosynthesis II (engineered)";"Activation of gene expression by SREBF (SREBP)";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"Mevalonate pathway I"
XP_053956023.1	2	KEGG: 00563+3.5.1.89;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053970179.1	2	Reactome: R-HSA-190873;Reactome: R-HSA-399719	"Gap junction degradation";"Trafficking of AMPA receptors"
XP_053955979.1	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
XP_053948711.1	9	KEGG: 00960+2.6.1.5;KEGG: 00350+2.6.1.5;Reactome: R-HSA-8963684;KEGG: 00400+2.6.1.5;KEGG: 00130+2.6.1.5;KEGG: 00270+2.6.1.5;KEGG: 00360+2.6.1.5;KEGG: 00401+2.6.1.5;KEGG: 00950+2.6.1.5	"Tropane, piperidine and pyridine alkaloid biosynthesis";"Tyrosine metabolism";"Tyrosine catabolism";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Cysteine and methionine metabolism";"Phenylalanine metabolism";"Novobiocin biosynthesis";"Isoquinoline alkaloid biosynthesis"
XP_053949986.1	2	Reactome: R-HSA-196819;KEGG: 00230+4.6.1.1	"Vitamin B1 (thiamin) metabolism";"Purine metabolism"
XP_053963222.1	57	Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-9604323;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4641258;Reactome: R-HSA-4641257;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-202424;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-5676590;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-382556;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-174178;Reactome: R-HSA-4608870;Reactome: R-HSA-450408;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-6798695	"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Hedgehog 'on' state";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"Negative regulation of NOTCH4 signaling";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of DVL";"Degradation of AXIN";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Downstream TCR signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"NIK-->noncanonical NF-kB signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"ABC-family proteins mediated transport";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Asymmetric localization of PCP proteins";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Neutrophil degranulation"
XP_053946677.1	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
XP_053945514.1	7	Reactome: R-HSA-2691232;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2660826	"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant"
XP_053947177.1	33	Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-168333;Reactome: R-HSA-141444;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-5663220;Reactome: R-HSA-3301854;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-9648025;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-168325;Reactome: R-HSA-168276	"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"RHO GTPases Activate Formins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways"
XP_053968105.1	6	Reactome: R-HSA-1369062;Reactome: R-HSA-2046106;Reactome: R-HSA-390247;Reactome: R-HSA-2046105;Reactome: R-HSA-5684045;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"alpha-linolenic acid (ALA) metabolism";"Beta-oxidation of very long chain fatty acids";"Linoleic acid (LA) metabolism";"Defective ABCD1 causes adrenoleukodystrophy (ALD)";"Class I peroxisomal membrane protein import"
XP_053962786.1	6	MetaCyc: PWY-7717;MetaCyc: PWY-6309;KEGG: 00380+1.14.13.9;MetaCyc: PWY-5651;Reactome: R-HSA-71240;MetaCyc: PWY-7765	"3-hydroxy-4-methyl-anthranilate biosynthesis I";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Tryptophan metabolism";"L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde";"Tryptophan catabolism";"3-hydroxy-4-methyl-anthranilate biosynthesis II"
XP_053960560.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053956821.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053958913.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_053967891.1	4	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053966992.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053958570.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053967414.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053960650.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053967301.1	5	Reactome: R-HSA-1655829;Reactome: R-HSA-5694530;Reactome: R-HSA-983170;Reactome: R-HSA-2132295;Reactome: R-HSA-204005	"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"MHC class II antigen presentation";"COPII-mediated vesicle transport"
XP_053946513.1	12	MetaCyc: PWY-5873;MetaCyc: PWY-5857;MetaCyc: PWY-6978;MetaCyc: PWY-5855;Reactome: R-HSA-1268020;MetaCyc: PWY-5872;MetaCyc: PWY-5871;MetaCyc: PWY-5870;KEGG: 00130+2.5.1.39;Reactome: R-HSA-2142789;MetaCyc: PWY-5856;MetaCyc: PWY-6708	"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol-7 biosynthesis (prokaryotic)";"Mitochondrial protein import";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)"
XP_053947700.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053953407.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053955983.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053957435.1	5	Reactome: R-HSA-936964;Reactome: R-HSA-918233;Reactome: R-HSA-9013973;Reactome: R-HSA-933541;Reactome: R-HSA-936440	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF3-dependent IRF activation pathway";"TICAM1-dependent activation of IRF3/IRF7";"TRAF6 mediated IRF7 activation";"Negative regulators of DDX58/IFIH1 signaling"
XP_053970183.1	2	Reactome: R-HSA-399719;Reactome: R-HSA-190873	"Trafficking of AMPA receptors";"Gap junction degradation"
XP_053952095.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053968525.1	5	Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-72163;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827	"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Major Pathway";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
XP_053962383.1	6	MetaCyc: PWY-6854;Reactome: R-HSA-8950505;Reactome: R-HSA-3299685;Reactome: R-HSA-2151201;Reactome: R-HSA-8862803;Reactome: R-HSA-9615017	"Ethylene biosynthesis III (microbes)";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Detoxification of Reactive Oxygen Species";"Transcriptional activation of mitochondrial biogenesis";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
XP_053952669.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_053948584.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053959381.1	17	Reactome: R-HSA-5693607;KEGG: 05163+2.7.11.1;Reactome: R-HSA-176187;Reactome: R-HSA-75035;Reactome: R-HSA-6804756;Reactome: R-HSA-6796648;Reactome: R-HSA-8953750;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-69601;Reactome: R-HSA-5693616;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69473;KEGG: 04151+2.7.11.1;Reactome: R-HSA-1433557;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1	"Processing of DNA double-strand break ends";"Human cytomegalovirus infection";"Activation of ATR in response to replication stress";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Regulation of TP53 Activity through Phosphorylation";"TP53 Regulates Transcription of DNA Repair Genes";"Transcriptional Regulation by E2F6";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Presynaptic phase of homologous DNA pairing and strand exchange";"Relaxin signaling pathway";"G2/M DNA damage checkpoint";"PI3K-Akt signaling pathway";"Signaling by SCF-KIT";"Human papillomavirus infection";"mTOR signaling pathway"
XP_053960957.1	9	Reactome: R-HSA-73776;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-6807505	"RNA Polymerase II Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA polymerase II transcribes snRNA genes"
XP_053958727.1	5	MetaCyc: PWY-5514;MetaCyc: PWY-6855;MetaCyc: PWY-6906;Reactome: R-HSA-70171;KEGG: 00520+3.5.99.6	"UDP-N-acetyl-D-galactosamine biosynthesis II";"Chitin degradation I (archaea)";"Chitin derivatives degradation";"Glycolysis";"Amino sugar and nucleotide sugar metabolism"
XP_053961636.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053952687.1	9	Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"Human cytomegalovirus infection";"tRNA modification in the nucleus and cytosol";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053961374.1	8	Reactome: R-HSA-9636467;Reactome: R-HSA-182218;Reactome: R-HSA-167590;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Blockage of phagosome acidification";"Nef Mediated CD8 Down-regulation";"Nef Mediated CD4 Down-regulation";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
XP_053952573.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_053963315.1	6	Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2467813	"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids"
XP_053945643.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053954103.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_053961428.1	6	KEGG: 04660+3.1.3.16;Reactome: R-HSA-400253;KEGG: 04658+3.1.3.16;Reactome: R-HSA-163560;KEGG: 05235+3.1.3.16;Reactome: R-HSA-2173788	"T cell receptor signaling pathway";"Circadian Clock";"Th1 and Th2 cell differentiation";"Triglyceride catabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Downregulation of TGF-beta receptor signaling"
XP_053953334.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_053962716.1	23	Reactome: R-HSA-400042;Reactome: R-HSA-432040;Reactome: R-HSA-500657;Reactome: R-HSA-420092;Reactome: R-HSA-428930;Reactome: R-HSA-8964616;Reactome: R-HSA-418594;Reactome: R-HSA-456926;Reactome: R-HSA-8964315;Reactome: R-HSA-9009391;Reactome: R-HSA-6814122;Reactome: R-HSA-416482;Reactome: R-HSA-392851;Reactome: R-HSA-381676;Reactome: R-HSA-392170;Reactome: R-HSA-418592;Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-392451;Reactome: R-HSA-418217;Reactome: R-HSA-202040;Reactome: R-HSA-418555;Reactome: R-HSA-4086398	"Adrenaline,noradrenaline inhibits insulin secretion";"Vasopressin regulates renal water homeostasis via Aquaporins";"Presynaptic function of Kainate receptors";"Glucagon-type ligand receptors";"Thromboxane signalling through TP receptor";"G beta:gamma signalling through CDC42";"G alpha (i) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through BTK";"Extra-nuclear estrogen signaling";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (12/13) signalling events";"Prostacyclin signalling through prostacyclin receptor";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 12";"ADP signalling through P2Y purinoceptor 1";"G alpha (z) signalling events";"G alpha (q) signalling events";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through PLC beta";"G-protein activation";"G alpha (s) signalling events";"Ca2+ pathway"
XP_053955570.1	7	Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-264870;Reactome: R-HSA-373753;Reactome: R-HSA-6798695;Reactome: R-HSA-5673001;Reactome: R-HSA-375165	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Caspase-mediated cleavage of cytoskeletal proteins";"Nephrin family interactions";"Neutrophil degranulation";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth"
XP_053952877.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053947010.1	7	Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053952218.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_053957763.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053966422.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053960231.1	5	Reactome: R-HSA-427389;Reactome: R-HSA-6804758;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724	"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"Regulation of PTEN gene transcription"
XP_053961347.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053957492.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053948781.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053948737.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053957355.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053947144.1	5	Reactome: R-HSA-8964539;MetaCyc: PWY-6344;MetaCyc: PWY-4981;MetaCyc: PWY-3341;KEGG: 00330+1.5.1.2	"Glutamate and glutamine metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism"
XP_053965310.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053946406.1	9	MetaCyc: PWY-5744;Reactome: R-HSA-1475029;MetaCyc: PWY-7117;MetaCyc: PWY-241;MetaCyc: PWY-5789;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5743;MetaCyc: PWY-7115	"Glyoxylate assimilation";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type"
XP_053959311.1	22	Reactome: R-HSA-2500257;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5673000;Reactome: R-HSA-196299;Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-6811558;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-432142;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-5467340;Reactome: R-HSA-5675221	"Resolution of Sister Chromatid Cohesion";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"RAF activation";"Beta-catenin phosphorylation cascade";"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"Platelet sensitization by LDL";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway"
XP_053959404.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053948001.1	6	Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220	"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins"
XP_053945711.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_053966598.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053955913.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053946887.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053970113.1	11	KEGG: 00051+5.3.1.8;MetaCyc: PWY-5659;MetaCyc: PWY-7456;MetaCyc: PWY-7586;Reactome: R-HSA-446205;KEGG: 00520+5.3.1.8;MetaCyc: PWY-3861;Reactome: R-HSA-4043916;MetaCyc: PWY-6992;MetaCyc: PWY-882;MetaCyc: PWY-3881	"Fructose and mannose metabolism";"GDP-mannose biosynthesis";"Beta-(1,4)-mannan degradation";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Synthesis of GDP-mannose";"Amino sugar and nucleotide sugar metabolism";"Mannitol degradation II";"Defective MPI causes MPI-CDG (CDG-1b)";"1,5-anhydrofructose degradation";"L-ascorbate biosynthesis I (L-galactose pathway)";"Mannitol biosynthesis"
XP_053952250.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053955196.1	3	Reactome: R-HSA-2142691;MetaCyc: PWY-7533;Reactome: R-HSA-5423646	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis";"Aflatoxin activation and detoxification"
XP_053963520.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053954523.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053955253.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_053967575.1	5	Reactome: R-HSA-75896;KEGG: 00565+2.5.1.26;Reactome: R-HSA-9033241;MetaCyc: PWY-7782;Reactome: R-HSA-9033500	"Plasmalogen biosynthesis";"Ether lipid metabolism";"Peroxisomal protein import";"Plasmalogen biosynthesis";"TYSND1 cleaves peroxisomal proteins"
XP_053947050.1	4	Reactome: R-HSA-2160916;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;Reactome: R-HSA-2206292	"Hyaluronan uptake and degradation";"Neutrophil degranulation";"HS-GAG degradation";"MPS VII - Sly syndrome"
XP_053952446.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053945034.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053955137.1	3	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
XP_053964966.1	5	Reactome: R-HSA-1912399;Reactome: R-HSA-1912420;Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-5083630	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Pre-NOTCH Processing in Golgi";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"Defective LFNG causes SCDO3"
XP_053949956.1	2	Reactome: R-HSA-1483148;Reactome: R-HSA-1483166	"Synthesis of PG";"Synthesis of PA"
XP_053962765.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053960931.1	7	Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-5663220	"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins"
XP_053957520.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053951034.1	13	Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination"
XP_053966590.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053952567.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053969861.1	7	Reactome: R-HSA-2660826;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2644606	"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_053956600.1	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
XP_053945751.1	9	Reactome: R-HSA-5696400;Reactome: R-HSA-5696394;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5696395;Reactome: R-HSA-8951664;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823	"Dual Incision in GG-NER";"DNA Damage Recognition in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Formation of Incision Complex in GG-NER";"Neddylation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex"
XP_053957315.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053960987.1	5	KEGG: 00760+6.3.4.21;Reactome: R-HSA-197264;Reactome: R-HSA-1368108;MetaCyc: PWY-5381;Reactome: R-HSA-6798695	"Nicotinate and nicotinamide metabolism";"Nicotinamide salvaging";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Pyridine nucleotide cycling (plants)";"Neutrophil degranulation"
XP_053952950.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053948393.1	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_053955181.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053948127.1	8	MetaCyc: PWY-7533;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7112;KEGG: 00980+2.5.1.18;MetaCyc: PWY-4061;MetaCyc: PWY-6842;KEGG: 00480+2.5.1.18;KEGG: 00983+2.5.1.18	"Gliotoxin biosynthesis";"Drug metabolism - cytochrome P450";"4-hydroxy-2-nonenal detoxification";"Metabolism of xenobiotics by cytochrome P450";"Glutathione-mediated detoxification I";"Glutathione-mediated detoxification II";"Glutathione metabolism";"Drug metabolism - other enzymes"
XP_053951751.1	24	Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-4086398;Reactome: R-HSA-202040;Reactome: R-HSA-418555;Reactome: R-HSA-392451;Reactome: R-HSA-418217;Reactome: R-HSA-163359;Reactome: R-HSA-8964315;Reactome: R-HSA-8964616;Reactome: R-HSA-456926;Reactome: R-HSA-418594;Reactome: R-HSA-420092;Reactome: R-HSA-500657;Reactome: R-HSA-428930;Reactome: R-HSA-432040;Reactome: R-HSA-400042;Reactome: R-HSA-418592;Reactome: R-HSA-381676;Reactome: R-HSA-392170;Reactome: R-HSA-392851;Reactome: R-HSA-6814122;Reactome: R-HSA-9009391;Reactome: R-HSA-416482	"G alpha (q) signalling events";"G alpha (z) signalling events";"Ca2+ pathway";"G-protein activation";"G alpha (s) signalling events";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through PLC beta";"Glucagon signaling in metabolic regulation";"G beta:gamma signalling through BTK";"G beta:gamma signalling through CDC42";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (i) signalling events";"Glucagon-type ligand receptors";"Presynaptic function of Kainate receptors";"Thromboxane signalling through TP receptor";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adrenaline,noradrenaline inhibits insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 12";"Prostacyclin signalling through prostacyclin receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Extra-nuclear estrogen signaling";"G alpha (12/13) signalling events"
XP_053958024.1	3	KEGG: 00511+3.2.1.45;KEGG: 00600+3.2.1.45;Reactome: R-HSA-1660662	"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid metabolism"
XP_053952210.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions"
XP_053953362.1	11	Reactome: R-HSA-193692;Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-205043;Reactome: R-HSA-2644606;Reactome: R-HSA-3928665;Reactome: R-HSA-9017802;Reactome: R-HSA-9013700;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-2122948	"Regulated proteolysis of p75NTR";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NRIF signals cell death from the nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"EPH-ephrin mediated repulsion of cells";"Noncanonical activation of NOTCH3";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"Activated NOTCH1 Transmits Signal to the Nucleus"
XP_053967481.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053961735.1	8	MetaCyc: PWY-7193;MetaCyc: PWY-7199;KEGG: 00983+3.5.4.5;KEGG: 00240+3.5.4.5;Reactome: R-HSA-6798695;MetaCyc: PWY-7181;Reactome: R-HSA-73614;MetaCyc: PWY-6556	"Pyrimidine ribonucleosides salvage I";"Pyrimidine deoxyribonucleosides salvage";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"Neutrophil degranulation";"Pyrimidine deoxyribonucleosides degradation";"Pyrimidine salvage";"Pyrimidine ribonucleosides salvage II"
XP_053954987.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053946927.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053952759.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053962442.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_053945714.1	14	MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876	"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs"
XP_053952752.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053945537.1	3	Reactome: R-HSA-8963684;Reactome: R-HSA-204174;Reactome: R-HSA-156590	"Tyrosine catabolism";"Regulation of pyruvate dehydrogenase (PDH) complex";"Glutathione conjugation"
XP_053962449.1	13	Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053958823.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053960234.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_053947738.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053950966.1	3	MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_053963405.1	4	KEGG: 00330+2.5.1.16;KEGG: 00270+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00480+2.5.1.16	"Arginine and proline metabolism";"Cysteine and methionine metabolism";"Metabolism of polyamines";"Glutathione metabolism"
XP_053947500.1	7	KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053969574.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053948345.1	1	MetaCyc: PWY-6938	"NADH repair"
XP_053947964.1	10	Reactome: R-HSA-9648895;Reactome: R-HSA-72706;Reactome: R-HSA-72731;Reactome: R-HSA-381042;Reactome: R-HSA-382556;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72649	"Response of EIF2AK1 (HRI) to heme deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Recycling of eIF2:GDP";"PERK regulates gene expression";"ABC-family proteins mediated transport";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation"
XP_053955184.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053959593.1	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
XP_053960523.1	42	Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-69473;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-2299718;Reactome: R-HSA-427413;Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-5693607;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-110331;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-9018519;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-3214815;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-5334118;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-977225	"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"G2/M DNA damage checkpoint";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"Condensation of Prophase Chromosomes";"NoRC negatively regulates rRNA expression";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Processing of DNA double-strand break ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Cleavage of the damaged purine";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Estrogen-dependent gene expression";"Meiotic recombination";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"HDACs deacetylate histones";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"DNA methylation";"Packaging Of Telomere Ends";"Meiotic synapsis";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation"
XP_053967496.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053958021.1	3	Reactome: R-HSA-1660662;KEGG: 00511+3.2.1.45;KEGG: 00600+3.2.1.45	"Glycosphingolipid metabolism";"Other glycan degradation";"Sphingolipid metabolism"
XP_053967331.1	9	MetaCyc: PWY-6147;MetaCyc: PWY-7852;MetaCyc: PWY-5664;Reactome: R-HSA-1474151;MetaCyc: PWY-6983;MetaCyc: PWY-5663;KEGG: 00790+3.5.4.16;MetaCyc: PWY-7442;MetaCyc: PWY-6703	"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Erythro-tetrahydrobiopterin biosynthesis II";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Threo-tetrahydrobiopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Preq0 biosynthesis"
XP_053961125.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053957852.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053952719.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_053958778.1	3	KEGG: 00310+2.1.1.60;Reactome: R-HSA-2514859;Reactome: R-HSA-8876725	"Lysine degradation";"Inactivation, recovery and regulation of the phototransduction cascade";"Protein methylation"
XP_053958040.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_053953437.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053960934.1	7	Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-5626467;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"RHO GTPases activate IQGAPs";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase"
XP_053956951.1	8	MetaCyc: PWY-8086;KEGG: 00620+1.1.1.27;KEGG: 00270+1.1.1.27;Reactome: R-HSA-70268;MetaCyc: PWY-5481;KEGG: 00010+1.1.1.27;MetaCyc: PWY-6901;KEGG: 00640+1.1.1.27	"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Cysteine and methionine metabolism";"Pyruvate metabolism";"Pyruvate fermentation to (S)-lactate";"Glycolysis / Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Propanoate metabolism"
XP_053967362.1	13	Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053947128.1	3	Reactome: R-HSA-2022854;Reactome: R-HSA-975577;Reactome: R-HSA-913709	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation";"O-linked glycosylation of mucins"
XP_053961505.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-6811436	"RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic"
XP_053969864.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_053945596.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_053965199.1	5	Reactome: R-HSA-2132295;Reactome: R-HSA-4341670;Reactome: R-HSA-6798695;Reactome: R-HSA-1660662;Reactome: R-HSA-4085001	"MHC class II antigen presentation";"Defective NEU1 causes sialidosis";"Neutrophil degranulation";"Glycosphingolipid metabolism";"Sialic acid metabolism"
XP_053959307.1	4	MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32	"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism"
XP_053960142.1	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
XP_053951596.1	16	Reactome: R-HSA-5693579;Reactome: R-HSA-5693616;Reactome: R-HSA-69473;Reactome: R-HSA-201722;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693548;Reactome: R-HSA-9018519;Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5693565;Reactome: R-HSA-5693568;Reactome: R-HSA-3214847;Reactome: R-HSA-5693571;Reactome: R-HSA-2559586	"Homologous DNA Pairing and Strand Exchange";"Presynaptic phase of homologous DNA pairing and strand exchange";"G2/M DNA damage checkpoint";"Formation of the beta-catenin:TCF transactivating complex";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Sensing of DNA Double Strand Breaks";"Estrogen-dependent gene expression";"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HATs acetylate histones";"Nonhomologous End-Joining (NHEJ)";"DNA Damage/Telomere Stress Induced Senescence"
XP_053963812.1	20	KEGG: 00410+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-7291;MetaCyc: PWY-6837;MetaCyc: PWY-7007;MetaCyc: PWY-7338;MetaCyc: PWY-7858;Reactome: R-HSA-9033241;MetaCyc: PWY-7726;MetaCyc: PWY-7340;MetaCyc: PWY-6920;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7288;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7337;MetaCyc: PWY-7574;MetaCyc: PWY-5136;MetaCyc: PWY-7854	"beta-Alanine metabolism";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Methyl ketone biosynthesis (engineered)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"Peroxisomal protein import";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid degradation";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)"
XP_053945661.1	4	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"DARPP-32 events";"Th1 and Th2 cell differentiation"
XP_053962565.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053966790.1	83	Reactome: R-HSA-8983432;Reactome: R-HSA-5654693;Reactome: R-HSA-112412;Reactome: R-HSA-6811558;Reactome: R-HSA-983695;Reactome: R-HSA-8875555;Reactome: R-HSA-5654700;Reactome: R-HSA-2424491;Reactome: R-HSA-5654710;Reactome: R-HSA-1433559;Reactome: R-HSA-912631;Reactome: R-HSA-389359;Reactome: R-HSA-5663213;Reactome: R-HSA-391160;Reactome: R-HSA-74751;Reactome: R-HSA-8853338;Reactome: R-HSA-5654706;Reactome: R-HSA-5654712;Reactome: R-HSA-210993;Reactome: R-HSA-9645135;Reactome: R-HSA-8865999;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-1839117;Reactome: R-HSA-2219530;Reactome: R-HSA-512988;Reactome: R-HSA-5655302;Reactome: R-HSA-8875656;Reactome: R-HSA-2871796;Reactome: R-HSA-186763;Reactome: R-HSA-8853659;Reactome: R-HSA-5655253;Reactome: R-HSA-8851907;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-8856825;Reactome: R-HSA-9027284;Reactome: R-HSA-2428933;Reactome: R-HSA-5654732;Reactome: R-HSA-74749;Reactome: R-HSA-9028731;Reactome: R-HSA-5654720;Reactome: R-HSA-9634285;Reactome: R-HSA-9607240;Reactome: R-HSA-179812;Reactome: R-HSA-1295596;Reactome: R-HSA-167044;Reactome: R-HSA-5654719;Reactome: R-HSA-2730905;Reactome: R-HSA-5637810;Reactome: R-HSA-5654699;Reactome: R-HSA-9026519;Reactome: R-HSA-2029482;Reactome: R-HSA-912526;Reactome: R-HSA-1963642;Reactome: R-HSA-8853334;Reactome: R-HSA-2871809;Reactome: R-HSA-5654704;Reactome: R-HSA-8856828;Reactome: R-HSA-5654727;Reactome: R-HSA-1433557;Reactome: R-HSA-5654726;Reactome: R-HSA-5655291;Reactome: R-HSA-1963640;Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-180292;Reactome: R-HSA-8851805;Reactome: R-HSA-180336;Reactome: R-HSA-8875360;Reactome: R-HSA-354194;Reactome: R-HSA-5654695;Reactome: R-HSA-5654688;Reactome: R-HSA-9664565;Reactome: R-HSA-1250347;Reactome: R-HSA-182971;Reactome: R-HSA-9034864;Reactome: R-HSA-1250196;Reactome: R-HSA-1236382;Reactome: R-HSA-1257604;Reactome: R-HSA-388841;Reactome: R-HSA-6807004;Reactome: R-HSA-9028335	"Interleukin-15 signaling";"FRS-mediated FGFR1 signaling";"SOS-mediated signalling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"MET activates RAP1 and RAC1";"FRS-mediated FGFR2 signaling";"DAP12 signaling";"PI-3K cascade:FGFR3";"Regulation of KIT signaling";"Regulation of signaling by CBL";"CD28 dependent Vav1 pathway";"RHO GTPases Activate WASPs and WAVEs";"Signal regulatory protein family interactions";"Insulin receptor signalling cascade";"Signaling by FGFR3 point mutants in cancer";"FRS-mediated FGFR3 signaling";"FRS-mediated FGFR4 signaling";"Tie2 Signaling";"STAT5 Activation";"MET activates PTPN11";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"Signaling by cytosolic FGFR1 fusion mutants";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Signaling by FGFR1 in disease";"MET receptor recycling";"FCERI mediated MAPK activation";"Downstream signal transduction";"RET signaling";"Signaling by FGFR2 in disease";"MET activates PI3K/AKT signaling";"EGFR Transactivation by Gastrin";"PI3K Cascade";"Cargo recognition for clathrin-mediated endocytosis";"Erythropoietin activates RAS";"SHC-related events triggered by IGF1R";"Negative regulation of FGFR3 signaling";"Signal attenuation";"Activated NTRK2 signals through FRS2 and FRS3";"PI-3K cascade:FGFR4";"Constitutive Signaling by Overexpressed ERBB2";"FLT3 Signaling";"GRB2 events in EGFR signaling";"Spry regulation of FGF signaling";"Signalling to RAS";"SHC-mediated cascade:FGFR4";"Role of LAT2/NTAL/LAB on calcium mobilization";"Constitutive Signaling by EGFRvIII";"SHC-mediated cascade:FGFR2";"Activated NTRK2 signals through RAS";"Regulation of actin dynamics for phagocytic cup formation";"Interleukin receptor SHC signaling";"PI3K events in ERBB2 signaling";"Signaling by FGFR3 fusions in cancer";"FCERI mediated Ca+2 mobilization";"SHC-mediated cascade:FGFR3";"Clathrin-mediated endocytosis";"Negative regulation of FGFR2 signaling";"Signaling by SCF-KIT";"Negative regulation of FGFR1 signaling";"Signaling by FGFR4 in disease";"GRB2 events in ERBB2 signaling";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"GAB1 signalosome";"MET activates RAS signaling";"SHC1 events in EGFR signaling";"InlB-mediated entry of Listeria monocytogenes into host cell";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"PI-3K cascade:FGFR2";"SHC-mediated cascade:FGFR1";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB4 signaling";"EGFR downregulation";"Activated NTRK3 signals through RAS";"SHC1 events in ERBB2 signaling";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"PIP3 activates AKT signaling";"Costimulation by the CD28 family";"Negative regulation of MET activity";"Activated NTRK2 signals through PI3K"
XP_053956237.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_053954217.1	3	KEGG: 00670+2.1.2.9;Reactome: R-HSA-5368286;KEGG: 00970+2.1.2.9	"One carbon pool by folate";"Mitochondrial translation initiation";"Aminoacyl-tRNA biosynthesis"
XP_053947943.1	8	Reactome: R-HSA-5340588;Reactome: R-HSA-373080;Reactome: R-HSA-4086398;Reactome: R-HSA-4641263;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-4608870;Reactome: R-HSA-5099900	"RNF mutants show enhanced WNT signaling and proliferation";"Class B/2 (Secretin family receptors)";"Ca2+ pathway";"Regulation of FZD by ubiquitination";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Asymmetric localization of PCP proteins";"WNT5A-dependent internalization of FZD4"
XP_053952782.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053957741.1	2	Reactome: R-HSA-382556;Reactome: R-HSA-5678895	"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis"
XP_053948031.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053946436.1	3	Reactome: R-HSA-8957275;Reactome: R-HSA-381038;Reactome: R-HSA-381426	"Post-translational protein phosphorylation";"XBP1(S) activates chaperone genes";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
XP_053954878.1	24	Reactome: R-HSA-418555;Reactome: R-HSA-202040;Reactome: R-HSA-4086398;Reactome: R-HSA-418217;Reactome: R-HSA-392451;Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-392170;Reactome: R-HSA-381676;Reactome: R-HSA-418592;Reactome: R-HSA-416482;Reactome: R-HSA-6814122;Reactome: R-HSA-9009391;Reactome: R-HSA-392851;Reactome: R-HSA-163359;Reactome: R-HSA-432040;Reactome: R-HSA-400042;Reactome: R-HSA-428930;Reactome: R-HSA-500657;Reactome: R-HSA-420092;Reactome: R-HSA-418594;Reactome: R-HSA-456926;Reactome: R-HSA-8964616;Reactome: R-HSA-8964315	"G alpha (s) signalling events";"G-protein activation";"Ca2+ pathway";"G beta:gamma signalling through PLC beta";"G beta:gamma signalling through PI3Kgamma";"G alpha (q) signalling events";"G alpha (z) signalling events";"ADP signalling through P2Y purinoceptor 12";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 1";"G alpha (12/13) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Extra-nuclear estrogen signaling";"Prostacyclin signalling through prostacyclin receptor";"Glucagon signaling in metabolic regulation";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adrenaline,noradrenaline inhibits insulin secretion";"Thromboxane signalling through TP receptor";"Presynaptic function of Kainate receptors";"Glucagon-type ligand receptors";"G alpha (i) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through CDC42";"G beta:gamma signalling through BTK"
XP_053969415.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053953226.1	12	Reactome: R-HSA-3322077;Reactome: R-HSA-173599;KEGG: 00520+2.7.7.9;MetaCyc: PWY-6527;KEGG: 00561+2.7.7.9;MetaCyc: PWY-7238;KEGG: 00500+2.7.7.9;KEGG: 00052+2.7.7.9;MetaCyc: PWY-3801;MetaCyc: PWY-7343;KEGG: 00040+2.7.7.9;MetaCyc: PWY-7817	"Glycogen synthesis";"Formation of the active cofactor, UDP-glucuronate";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"Glycerolipid metabolism";"Sucrose biosynthesis II";"Starch and sucrose metabolism";"Galactose metabolism";"Sucrose degradation II (sucrose synthase)";"UDP-alpha-D-glucose biosynthesis I";"Pentose and glucuronate interconversions";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_053967451.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053951632.1	1	Reactome: R-HSA-196741	"Cobalamin (Cbl, vitamin B12) transport and metabolism"
XP_053962666.1	5	Reactome: R-HSA-917729;Reactome: R-HSA-9615710;Reactome: R-HSA-162588;Reactome: R-HSA-9610379;Reactome: R-HSA-174490	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy";"Budding and maturation of HIV virion";"HCMV Late Events";"Membrane binding and targetting of GAG proteins"
XP_053951551.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_053963889.1	8	MetaCyc: PWY-7210;MetaCyc: PWY-7184;MetaCyc: PWY-7187;MetaCyc: PWY-7197;MetaCyc: PWY-7198;KEGG: 00240+2.7.4.9;Reactome: R-HSA-499943;MetaCyc: PWY-6545	"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III"
XP_053965276.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (q) signalling events";"Peptide ligand-binding receptors"
XP_053955040.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053948170.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053962655.1	2	Reactome: R-HSA-1660499;Reactome: R-HSA-1632852	"Synthesis of PIPs at the plasma membrane";"Macroautophagy"
XP_053956638.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876	"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing"
XP_053957613.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053952043.1	5	Reactome: R-HSA-5218921;Reactome: R-HSA-186763;Reactome: R-HSA-3928662;Reactome: R-HSA-5658442;Reactome: R-HSA-8849471	"VEGFR2 mediated cell proliferation";"Downstream signal transduction";"EPHB-mediated forward signaling";"Regulation of RAS by GAPs";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"
XP_053949994.1	5	Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757	"Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation"
XP_053956996.1	3	Reactome: R-HSA-2206296;Reactome: R-HSA-2024101;Reactome: R-HSA-2024096	"MPS II - Hunter syndrome";"CS/DS degradation";"HS-GAG degradation"
XP_053954257.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_053957889.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053950098.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053948581.1	4	Reactome: R-HSA-3000170;Reactome: R-HSA-2129379;Reactome: R-HSA-3000178;Reactome: R-HSA-216083	"Syndecan interactions";"Molecules associated with elastic fibres";"ECM proteoglycans";"Integrin cell surface interactions"
XP_053954917.1	13	MetaCyc: PWY-7822;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-1660662;KEGG: 00603+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7883	"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"CS/DS degradation";"Other glycan degradation";"Anhydromuropeptides recycling II"
XP_053967304.1	16	Reactome: R-HSA-975110;Reactome: R-HSA-975871;Reactome: R-HSA-5603041;Reactome: R-HSA-975138;Reactome: R-HSA-5602498;Reactome: R-HSA-209543;Reactome: R-HSA-1810476;Reactome: R-HSA-1257604;Reactome: R-HSA-1236974;Reactome: R-HSA-5602680;Reactome: R-HSA-5603037;Reactome: R-HSA-975155;Reactome: R-HSA-9020702;Reactome: R-HSA-166058;Reactome: R-HSA-3134963;Reactome: R-HSA-6811558	"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"MyD88 cascade initiated on plasma membrane";"IRAK4 deficiency (TLR2/4)";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"MyD88 deficiency (TLR2/4)";"p75NTR recruits signalling complexes";"RIP-mediated NFkB activation via ZBP1";"PIP3 activates AKT signaling";"ER-Phagosome pathway";"MyD88 deficiency (TLR5)";"IRAK4 deficiency (TLR5)";"MyD88 dependent cascade initiated on endosome";"Interleukin-1 signaling";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
XP_053953926.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053955770.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053955048.1	1	Reactome: R-HSA-5683826	"Surfactant metabolism"
XP_053953317.1	2	Reactome: R-HSA-6793080;Reactome: R-HSA-2151201	"rRNA modification in the mitochondrion";"Transcriptional activation of mitochondrial biogenesis"
XP_053969809.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_053956824.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053949826.1	3	Reactome: R-HSA-5423646;Reactome: R-HSA-5579007;KEGG: 00220+3.5.1.14	"Aflatoxin activation and detoxification";"Defective ACY1 causes encephalopathy";"Arginine biosynthesis"
XP_053969399.1	4	KEGG: 00450+2.9.1.2;MetaCyc: PWY-6281;KEGG: 00970+2.9.1.2;Reactome: R-HSA-2408557	"Selenocompound metabolism";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis";"Selenocysteine synthesis"
XP_053950329.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053963720.1	4	KEGG: 00970+6.1.1.10;Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00450+6.1.1.10	"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Selenocompound metabolism"
XP_053946783.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053954723.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053950322.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053957728.1	10	Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-912446;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-5693579;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Meiotic recombination";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Homologous DNA Pairing and Strand Exchange";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_053961846.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053948537.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053954658.1	2	Reactome: R-HSA-1483152;Reactome: R-HSA-1483115	"Hydrolysis of LPE";"Hydrolysis of LPC"
XP_053952376.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053953775.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_053954870.1	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
XP_053963741.1	9	Reactome: R-HSA-165159;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-5674135;Reactome: R-HSA-8943724;Reactome: R-HSA-6798695;Reactome: R-HSA-380972;Reactome: R-HSA-9639288	"mTOR signalling";"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTORC1-mediated signalling";"MAP2K and MAPK activation";"Regulation of PTEN gene transcription";"Neutrophil degranulation";"Energy dependent regulation of mTOR by LKB1-AMPK";"Amino acids regulate mTORC1"
XP_053957071.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053959512.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053963349.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053963303.1	1	Reactome: R-HSA-71262	"Carnitine synthesis"
XP_053962895.1	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
XP_053967908.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876	"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing"
XP_053963086.1	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
XP_053946477.1	15	KEGG: 00010+2.7.1.40;MetaCyc: PWY-5723;MetaCyc: PWY-7383;Reactome: R-HSA-70171;MetaCyc: PWY-8004;MetaCyc: PWY-2221;MetaCyc: PWY-6886;MetaCyc: PWY-1042;MetaCyc: PWY-7003;KEGG: 00230+2.7.1.40;MetaCyc: PWY-5484;MetaCyc: PWY-6901;MetaCyc: PWY-7218;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6142	"Glycolysis / Gluconeogenesis";"Rubisco shunt";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis";"Entner-Doudoroff pathway I";"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Glycerol degradation to butanol";"Purine metabolism";"Glycolysis II (from fructose 6-phosphate)";"Superpathway of glucose and xylose degradation";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Pyruvate metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
XP_053966778.1	83	Reactome: R-HSA-5654699;Reactome: R-HSA-5637810;Reactome: R-HSA-2730905;Reactome: R-HSA-5654719;Reactome: R-HSA-167044;Reactome: R-HSA-1295596;Reactome: R-HSA-179812;Reactome: R-HSA-9607240;Reactome: R-HSA-5654720;Reactome: R-HSA-9634285;Reactome: R-HSA-2029482;Reactome: R-HSA-9026519;Reactome: R-HSA-5654704;Reactome: R-HSA-2871809;Reactome: R-HSA-1963642;Reactome: R-HSA-8853334;Reactome: R-HSA-912526;Reactome: R-HSA-1963640;Reactome: R-HSA-5655291;Reactome: R-HSA-5654726;Reactome: R-HSA-1433557;Reactome: R-HSA-5654727;Reactome: R-HSA-8856828;Reactome: R-HSA-180336;Reactome: R-HSA-8851805;Reactome: R-HSA-180292;Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-1250347;Reactome: R-HSA-9664565;Reactome: R-HSA-5654688;Reactome: R-HSA-5654695;Reactome: R-HSA-354194;Reactome: R-HSA-8875360;Reactome: R-HSA-388841;Reactome: R-HSA-1257604;Reactome: R-HSA-1236382;Reactome: R-HSA-1250196;Reactome: R-HSA-9034864;Reactome: R-HSA-182971;Reactome: R-HSA-9028335;Reactome: R-HSA-6807004;Reactome: R-HSA-5654700;Reactome: R-HSA-8875555;Reactome: R-HSA-983695;Reactome: R-HSA-112412;Reactome: R-HSA-6811558;Reactome: R-HSA-5654693;Reactome: R-HSA-8983432;Reactome: R-HSA-2424491;Reactome: R-HSA-5663213;Reactome: R-HSA-389359;Reactome: R-HSA-74751;Reactome: R-HSA-391160;Reactome: R-HSA-912631;Reactome: R-HSA-1433559;Reactome: R-HSA-5654710;Reactome: R-HSA-8865999;Reactome: R-HSA-9645135;Reactome: R-HSA-210993;Reactome: R-HSA-5654712;Reactome: R-HSA-5654706;Reactome: R-HSA-8853338;Reactome: R-HSA-8875656;Reactome: R-HSA-5655302;Reactome: R-HSA-2219530;Reactome: R-HSA-512988;Reactome: R-HSA-1839117;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-186763;Reactome: R-HSA-2871796;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-8851907;Reactome: R-HSA-5655253;Reactome: R-HSA-8853659;Reactome: R-HSA-9028731;Reactome: R-HSA-74749;Reactome: R-HSA-5654732;Reactome: R-HSA-2428933;Reactome: R-HSA-9027284;Reactome: R-HSA-8856825	"SHC-mediated cascade:FGFR2";"Constitutive Signaling by EGFRvIII";"Role of LAT2/NTAL/LAB on calcium mobilization";"SHC-mediated cascade:FGFR4";"Signalling to RAS";"Spry regulation of FGF signaling";"GRB2 events in EGFR signaling";"FLT3 Signaling";"PI-3K cascade:FGFR4";"Constitutive Signaling by Overexpressed ERBB2";"Regulation of actin dynamics for phagocytic cup formation";"Activated NTRK2 signals through RAS";"SHC-mediated cascade:FGFR3";"FCERI mediated Ca+2 mobilization";"PI3K events in ERBB2 signaling";"Signaling by FGFR3 fusions in cancer";"Interleukin receptor SHC signaling";"GRB2 events in ERBB2 signaling";"Signaling by FGFR4 in disease";"Negative regulation of FGFR1 signaling";"Signaling by SCF-KIT";"Negative regulation of FGFR2 signaling";"Clathrin-mediated endocytosis";"SHC1 events in EGFR signaling";"MET activates RAS signaling";"GAB1 signalosome";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"SHC1 events in ERBB4 signaling";"Signaling by ERBB2 KD Mutants";"SHC-mediated cascade:FGFR1";"PI-3K cascade:FGFR2";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"InlB-mediated entry of Listeria monocytogenes into host cell";"Costimulation by the CD28 family";"PIP3 activates AKT signaling";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"SHC1 events in ERBB2 signaling";"Activated NTRK3 signals through RAS";"EGFR downregulation";"Activated NTRK2 signals through PI3K";"Negative regulation of MET activity";"FRS-mediated FGFR2 signaling";"MET activates RAP1 and RAC1";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"SOS-mediated signalling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"FRS-mediated FGFR1 signaling";"Interleukin-15 signaling";"DAP12 signaling";"RHO GTPases Activate WASPs and WAVEs";"CD28 dependent Vav1 pathway";"Insulin receptor signalling cascade";"Signal regulatory protein family interactions";"Regulation of signaling by CBL";"Regulation of KIT signaling";"PI-3K cascade:FGFR3";"MET activates PTPN11";"STAT5 Activation";"Tie2 Signaling";"FRS-mediated FGFR4 signaling";"FRS-mediated FGFR3 signaling";"Signaling by FGFR3 point mutants in cancer";"MET receptor recycling";"Signaling by FGFR1 in disease";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Signaling by cytosolic FGFR1 fusion mutants";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"Downstream signal transduction";"FCERI mediated MAPK activation";"EGFR Transactivation by Gastrin";"PI3K Cascade";"MET activates PI3K/AKT signaling";"Signaling by FGFR2 in disease";"RET signaling";"Activated NTRK2 signals through FRS2 and FRS3";"Signal attenuation";"Negative regulation of FGFR3 signaling";"SHC-related events triggered by IGF1R";"Erythropoietin activates RAS";"Cargo recognition for clathrin-mediated endocytosis"
XP_053966040.1	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
XP_053969372.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes"
XP_053962110.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053965996.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_053955905.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053967200.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053960946.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_053961772.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_053950131.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_053963536.1	6	Reactome: R-HSA-5545483;Reactome: R-HSA-5358606;Reactome: R-HSA-5358565;Reactome: R-HSA-6796648;Reactome: R-HSA-912446;Reactome: R-HSA-5632987	"Defective Mismatch Repair Associated With MLH1";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"TP53 Regulates Transcription of DNA Repair Genes";"Meiotic recombination";"Defective Mismatch Repair Associated With PMS2"
XP_053961386.1	12	MetaCyc: PWY-6613;KEGG: 00230+6.3.3.1;KEGG: 00230+2.1.2.2;KEGG: 00670+2.1.2.9;KEGG: 00230+6.3.4.13;MetaCyc: PWY-6277;Reactome: R-HSA-73817;KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.2;MetaCyc: PWY-6122;MetaCyc: PWY-6121;Reactome: R-HSA-196780	"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine metabolism";"Purine metabolism";"One carbon pool by folate";"Purine metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"5-aminoimidazole ribonucleotide biosynthesis II";"5-aminoimidazole ribonucleotide biosynthesis I";"Biotin transport and metabolism"
XP_053959552.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053959288.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053951464.1	14	Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-5620924;Reactome: R-HSA-6811436;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-1632852;Reactome: R-HSA-3371497	"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"HCMV Early Events";"Intraflagellar transport";"COPI-independent Golgi-to-ER retrograde traffic";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"Aggrephagy";"Mitotic Prometaphase";"Macroautophagy";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
XP_053961042.1	4	Reactome: R-HSA-156581;KEGG: 00270+2.5.1.6;MetaCyc: PWY-5041;MetaCyc: PWY-5912	"Methylation";"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II";"2'-deoxymugineic acid phytosiderophore biosynthesis"
XP_053967208.1	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
XP_053963091.1	5	MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7269;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23	"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_053954898.1	5	MetaCyc: PWY-7176;MetaCyc: PWY-7185;MetaCyc: PWY-7177;Reactome: R-HSA-499943;KEGG: 00240+6.3.4.2	"UTP and CTP de novo biosynthesis";"UTP and CTP dephosphorylation I";"UTP and CTP dephosphorylation II";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine metabolism"
XP_053961003.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053966823.1	8	Reactome: R-HSA-8953750;Reactome: R-HSA-111458;Reactome: R-HSA-111459;Reactome: R-HSA-111464;Reactome: R-HSA-6803207;Reactome: R-HSA-111463;Reactome: R-HSA-6798695;Reactome: R-HSA-9627069	"Transcriptional Regulation by E2F6";"Formation of apoptosome";"Activation of caspases through apoptosome-mediated cleavage";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"TP53 Regulates Transcription of Caspase Activators and Caspases";"SMAC (DIABLO) binds to IAPs";"Neutrophil degranulation";"Regulation of the apoptosome activity"
XP_053968251.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_053957597.1	6	Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72649	"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation"
XP_053951885.1	4	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-6807505;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"RNA polymerase II transcribes snRNA genes";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053961783.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053946846.1	14	MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7601;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199	"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation"
XP_053950748.1	5	Reactome: R-HSA-1912408;Reactome: R-HSA-5083630;Reactome: R-HSA-1912420;Reactome: R-HSA-1912399;Reactome: R-HSA-350054	"Pre-NOTCH Transcription and Translation";"Defective LFNG causes SCDO3";"Pre-NOTCH Processing in Golgi";"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Notch-HLH transcription pathway"
XP_053957349.1	5	Reactome: R-HSA-2219530;Reactome: R-HSA-5673001;Reactome: R-HSA-109704;Reactome: R-HSA-1257604;Reactome: R-HSA-6811558	"Constitutive Signaling by Aberrant PI3K in Cancer";"RAF/MAP kinase cascade";"PI3K Cascade";"PIP3 activates AKT signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
XP_053957303.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053965296.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053959095.1	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
XP_053955798.1	14	MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199	"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation"
XP_053955205.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053969383.1	19	Reactome: R-HSA-5686938;Reactome: R-HSA-8963888;Reactome: R-HSA-8963901;Reactome: R-HSA-8964038;Reactome: R-HSA-3000480;Reactome: R-HSA-8866423;Reactome: R-HSA-8964046;Reactome: R-HSA-381426;Reactome: R-HSA-8964041;Reactome: R-HSA-8964026;Reactome: R-HSA-432142;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-3000497;Reactome: R-HSA-8957275;Reactome: R-HSA-975634;Reactome: R-HSA-3000484;Reactome: R-HSA-202733;Reactome: R-HSA-3000471	"Regulation of TLR by endogenous ligand";"Chylomicron assembly";"Chylomicron remodeling";"LDL clearance";"Scavenging by Class A Receptors";"VLDL assembly";"VLDL clearance";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"LDL remodeling";"Chylomicron clearance";"Platelet sensitization by LDL";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Scavenging by Class H Receptors";"Post-translational protein phosphorylation";"Retinoid metabolism and transport";"Scavenging by Class F Receptors";"Cell surface interactions at the vascular wall";"Scavenging by Class B Receptors"
XP_053953908.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053946799.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053967900.1	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
XP_053950162.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_053959573.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_053968296.1	12	KEGG: 00680+4.1.2.13;Reactome: R-HSA-70171;KEGG: 00030+4.1.2.13;KEGG: 00010+4.1.2.13;KEGG: 00710+4.1.2.13;MetaCyc: PWY-1861;MetaCyc: PWY-5484;MetaCyc: PWY-1042;Reactome: R-HSA-70263;MetaCyc: PWY-7385;KEGG: 00051+4.1.2.13;MetaCyc: PWY-6142	"Methane metabolism";"Glycolysis";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)";"Fructose and mannose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
XP_053959032.1	2	Reactome: R-HSA-1799339;Reactome: R-HSA-1236974	"SRP-dependent cotranslational protein targeting to membrane";"ER-Phagosome pathway"
XP_053961620.1	5	MetaCyc: PWY-6902;MetaCyc: PWY-6855;MetaCyc: PWY-7822;Reactome: R-HSA-189085;KEGG: 00520+3.2.1.14	"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Digestion of dietary carbohydrate";"Amino sugar and nucleotide sugar metabolism"
XP_053946735.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_053969716.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_053963056.1	1	Reactome: R-HSA-912446	"Meiotic recombination"
XP_053952457.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053961641.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053947360.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_053949947.1	2	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_053963692.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053950233.1	26	Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-210744;Reactome: R-HSA-5621575;Reactome: R-HSA-1234158;Reactome: R-HSA-9013508;Reactome: R-HSA-1368082;Reactome: R-HSA-400253;Reactome: R-HSA-3134973;Reactome: R-HSA-3899300;Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-381340;Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-3371568;Reactome: R-HSA-2122947;Reactome: R-HSA-9617629;Reactome: R-HSA-933541;Reactome: R-HSA-8866907;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-918233;Reactome: R-HSA-1989781;Reactome: R-HSA-9614657;Reactome: R-HSA-9018519	"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"CD209 (DC-SIGN) signaling";"Regulation of gene expression by Hypoxia-inducible Factor";"NOTCH3 Intracellular Domain Regulates Transcription";"RORA activates gene expression";"Circadian Clock";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"SUMOylation of transcription cofactors";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"Attenuation phase";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"TRAF6 mediated IRF7 activation";"Activation of the TFAP2 (AP-2) family of transcription factors";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF3-dependent IRF activation pathway";"PPARA activates gene expression";"FOXO-mediated transcription of cell death genes";"Estrogen-dependent gene expression"
XP_053958798.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053960338.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053953543.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053965172.1	1	Reactome: R-HSA-880009	"Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"
XP_053964540.1	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
XP_053957016.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053962063.1	14	KEGG: 00020+1.3.5.1;MetaCyc: PWY-7254;KEGG: 00190+1.3.5.1;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-7279;MetaCyc: PWY-4302;MetaCyc: PWY-561;KEGG: 00650+1.3.5.1;MetaCyc: PWY-3781;Reactome: R-HSA-611105;MetaCyc: PWY-6969;KEGG: 00720+1.3.5.1;MetaCyc: PWY-5690	"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Oxidative phosphorylation";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Butanoate metabolism";"Aerobic respiration I (cytochrome c)";"Respiratory electron transport";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)"
XP_053961834.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_053959061.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
XP_053967847.1	4	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053950104.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053963016.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053967502.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_053952417.1	2	Reactome: R-HSA-8866654;Reactome: R-HSA-9033241	"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import"
XP_053953732.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_053946444.1	22	Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-6811558;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-5663220;Reactome: R-HSA-195253;Reactome: R-HSA-2500257;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716	"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"RHO GTPases Activate Formins";"Degradation of beta-catenin by the destruction complex";"Resolution of Sister Chromatid Cohesion";"Beta-catenin phosphorylation cascade";"RAF activation";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin"
XP_053961356.1	24	Reactome: R-HSA-8963896;Reactome: R-HSA-5610785;Reactome: R-HSA-9634600;Reactome: R-HSA-180024;Reactome: R-HSA-5621575;Reactome: R-HSA-9010642;KEGG: 04150+2.7.11.11;Reactome: R-HSA-392517;Reactome: R-HSA-163358;Reactome: R-HSA-163615;Reactome: R-HSA-111931;Reactome: R-HSA-983231;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-381676;Reactome: R-HSA-5610783;Reactome: R-HSA-163560;Reactome: R-HSA-4420097;Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-422356;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-8853659	"HDL assembly";"GLI3 is processed to GLI3R by the proteasome";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"DARPP-32 events";"CD209 (DC-SIGN) signaling";"ROBO receptors bind AKAP5";"mTOR signaling pathway";"Rap1 signalling";"PKA-mediated phosphorylation of key metabolic factors";"PKA activation";"PKA-mediated phosphorylation of CREB";"Factors involved in megakaryocyte development and platelet production";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Degradation of GLI2 by the proteasome";"Triglyceride catabolism";"VEGFA-VEGFR2 Pathway";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"Regulation of insulin secretion";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"RET signaling"
XP_053959589.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053967684.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053959258.1	3	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-3928662	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling"
XP_053959582.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_053950933.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_053946125.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_053961227.1	4	Reactome: R-HSA-5250958;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361	"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Neurexins and neuroligins"
XP_053962832.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053951198.1	52	Reactome: R-HSA-72163;Reactome: R-HSA-72086;Reactome: R-HSA-73863;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-77075;Reactome: R-HSA-167160;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-167287;Reactome: R-HSA-72203;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-72165;Reactome: R-HSA-8851708;Reactome: R-HSA-5617472;Reactome: R-HSA-76066;Reactome: R-HSA-6803529;Reactome: R-HSA-5250924;Reactome: R-HSA-6807505;Reactome: R-HSA-167246;Reactome: R-HSA-168325;Reactome: R-HSA-203927;Reactome: R-HSA-6781823;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-73776;Reactome: R-HSA-76061;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-6781827;Reactome: R-HSA-167162;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-76071;Reactome: R-HSA-5578749;Reactome: R-HSA-5601884;Reactome: R-HSA-167238;Reactome: R-HSA-167200;Reactome: R-HSA-9018519;Reactome: R-HSA-1834949;Reactome: R-HSA-75953;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-167242	"mRNA Splicing - Major Pathway";"mRNA Capping";"RNA Polymerase I Transcription Termination";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"HIV elongation arrest and recovery";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"mRNA Splicing - Minor Pathway";"Signaling by FGFR2 IIIa TM";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"FGFR2 alternative splicing";"B-WICH complex positively regulates rRNA expression";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript";"Viral Messenger RNA Synthesis";"MicroRNA (miRNA) biogenesis";"Formation of TC-NER Pre-Incision Complex";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"RNA Polymerase II Promoter Escape";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II HIV Promoter Escape";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Transcriptional regulation by small RNAs";"PIWI-interacting RNA (piRNA) biogenesis";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Estrogen-dependent gene expression";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase II Transcription Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat"
XP_053962839.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053956408.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_053950157.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_053953476.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053952351.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053961628.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053965951.1	1	Reactome: R-HSA-189451	"Heme biosynthesis"
XP_053953761.1	7	Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2691232;MetaCyc: PWY-7511;Reactome: R-HSA-2894862;Reactome: R-HSA-2979096	"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
XP_053967122.1	6	Reactome: R-HSA-418597;Reactome: R-HSA-76005;Reactome: R-HSA-5099900;Reactome: R-HSA-416993;Reactome: R-HSA-114516;KEGG: 04070+2.7.11.13	"G alpha (z) signalling events";"Response to elevated platelet cytosolic Ca2+";"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors";"Disinhibition of SNARE formation";"Phosphatidylinositol signaling system"
XP_053945866.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
XP_053957692.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053946428.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_053965254.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_053961831.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053964524.1	13	Reactome: R-HSA-975163;Reactome: R-HSA-937072;Reactome: R-HSA-9020702;Reactome: R-HSA-450302;Reactome: R-HSA-9014325;Reactome: R-HSA-2871837;Reactome: R-HSA-445989;Reactome: R-HSA-9645460;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-937042;Reactome: R-HSA-450321;Reactome: R-HSA-5607764	"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Interleukin-1 signaling";"activated TAK1 mediates p38 MAPK activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"FCERI mediated NF-kB activation";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Alpha-protein kinase 1 signaling pathway";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"IRAK2 mediated activation of TAK1 complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"CLEC7A (Dectin-1) signaling"
XP_053946066.1	2	Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2	"Signaling by SCF-KIT";"T cell receptor signaling pathway"
XP_053953238.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_053959064.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
XP_053957797.1	13	Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053951352.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053969442.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053963736.1	9	Reactome: R-HSA-6782210;Reactome: R-HSA-110314;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-5696400;Reactome: R-HSA-8951664;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-5696395	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Dual Incision in GG-NER";"Neddylation";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of Incision Complex in GG-NER"
XP_053962335.1	8	Reactome: R-HSA-381676;Reactome: R-HSA-163615;Reactome: R-HSA-983231;Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-180024;Reactome: R-HSA-164378;Reactome: R-HSA-5610787	"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"PKA activation";"Factors involved in megakaryocyte development and platelet production";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"DARPP-32 events";"PKA activation in glucagon signalling";"Hedgehog 'off' state"
XP_053966570.1	3	Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807	"Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism"
XP_053969449.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053949830.1	3	KEGG: 00220+3.5.1.14;Reactome: R-HSA-5423646;Reactome: R-HSA-5579007	"Arginine biosynthesis";"Aflatoxin activation and detoxification";"Defective ACY1 causes encephalopathy"
XP_053969403.1	8	Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-174411;Reactome: R-HSA-69166;Reactome: R-HSA-174430;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-69091	"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"Polymerase switching on the C-strand of the telomere";"Removal of the Flap Intermediate";"Telomere C-strand synthesis initiation";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Polymerase switching"
XP_053961644.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053966868.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053950027.1	12	Reactome: R-HSA-9646399;Reactome: R-HSA-3371497;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-6807878;Reactome: R-HSA-141444;Reactome: R-HSA-5663220	"Aggrephagy";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"HCMV Early Events";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"COPI-mediated anterograde transport";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins"
XP_053961583.1	6	Reactome: R-HSA-210500;Reactome: R-HSA-388844;Reactome: R-HSA-212676;Reactome: R-HSA-181430;Reactome: R-HSA-181429;Reactome: R-HSA-264642	"Glutamate Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Dopamine Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle"
XP_053963479.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_053948439.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053961862.1	8	KEGG: 04151+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"PI3K-Akt signaling pathway";"Signaling by Hippo";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053955235.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation"
XP_053968023.1	2	Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
XP_053952897.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053969591.1	57	Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-6798695;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-450408;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-69481;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-9604323;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-5358346	"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Neutrophil degranulation";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"G2/M Checkpoints";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Negative regulation of NOTCH4 signaling";"Neddylation";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Hedgehog ligand biogenesis"
XP_053959712.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053958299.1	27	Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-168333;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-168325;Reactome: R-HSA-168276	"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways"
XP_053952354.1	3	Reactome: R-HSA-2142691;MetaCyc: PWY-7533;Reactome: R-HSA-5423646	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis";"Aflatoxin activation and detoxification"
XP_053956318.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053948389.1	6	MetaCyc: PWY-7817;MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism"
XP_053961579.1	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
XP_053953230.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053962864.1	16	Reactome: R-HSA-983168;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-8951664;Reactome: R-HSA-167200;Reactome: R-HSA-9010553;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-1234176;Reactome: R-HSA-167246;Reactome: R-HSA-180585;Reactome: R-HSA-674695;Reactome: R-HSA-6796648	"Antigen processing: Ubiquitination & Proteasome degradation";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Neddylation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Regulation of expression of SLITs and ROBOs";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Tat-mediated elongation of the HIV-1 transcript";"Vif-mediated degradation of APOBEC3G";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes"
XP_053963483.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053967681.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_053962642.1	1	Reactome: R-HSA-212300	"PRC2 methylates histones and DNA"
XP_053963506.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053950101.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053959601.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053962649.1	20	Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-5913;Reactome: R-HSA-6798695;MetaCyc: PWY-7384;Reactome: R-HSA-1268020;KEGG: 00660+6.2.1.5;KEGG: 00020+2.3.3.8;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5538;KEGG: 00020+6.2.1.5;Reactome: R-HSA-163765;MetaCyc: PWY-6969;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5392;Reactome: R-HSA-75105;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-5172;MetaCyc: PWY-5537	"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"Neutrophil degranulation";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Mitochondrial protein import";"C5-Branched dibasic acid metabolism";"Citrate cycle (TCA cycle)";"Propanoate metabolism";"Pyruvate fermentation to acetate VI";"Citrate cycle (TCA cycle)";"ChREBP activates metabolic gene expression";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Fatty acyl-CoA biosynthesis";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Acetyl-coa biosynthesis III (from citrate)";"Pyruvate fermentation to acetate V"
XP_053946441.1	22	Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-2500257;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5673000;Reactome: R-HSA-196299;Reactome: R-HSA-432142;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-6811558;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752	"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Resolution of Sister Chromatid Cohesion";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"RAF activation";"Beta-catenin phosphorylation cascade";"Platelet sensitization by LDL";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated"
XP_053948046.1	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
XP_053956388.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053945382.1	3	Reactome: R-HSA-375276;Reactome: R-HSA-418594;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (i) signalling events";"G alpha (q) signalling events"
XP_053945367.1	7	Reactome: R-HSA-2660826;Reactome: R-HSA-2894862;Reactome: R-HSA-177929;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-1442490;Reactome: R-HSA-2691232	"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Signaling by EGFR";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Collagen degradation";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
XP_053957094.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053952434.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053953651.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
XP_053957453.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_053953539.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053967702.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053969556.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_053949159.1	5	Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-6783310;Reactome: R-HSA-5696395;Reactome: R-HSA-5685938	"Dual Incision in GG-NER";"Dual incision in TC-NER";"Fanconi Anemia Pathway";"Formation of Incision Complex in GG-NER";"HDR through Single Strand Annealing (SSA)"
XP_053953532.1	3	Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs"
XP_053964748.1	6	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_053962415.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053964070.1	3	Reactome: R-HSA-1268020;Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Mitochondrial protein import";"Respiratory electron transport";"Complex I biogenesis"
XP_053951382.1	6	KEGG: 05235+3.1.3.16;Reactome: R-HSA-2173788;Reactome: R-HSA-163560;Reactome: R-HSA-400253;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Downregulation of TGF-beta receptor signaling";"Triglyceride catabolism";"Circadian Clock";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053957845.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053967709.1	30	Reactome: R-HSA-9614399;Reactome: R-HSA-9634638;Reactome: R-HSA-389357;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 05165+2.7.11.1;Reactome: R-HSA-1257604;Reactome: R-HSA-1358803;Reactome: R-HSA-211163;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5674400;Reactome: R-HSA-69656;Reactome: R-HSA-8941332;Reactome: R-HSA-198693;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-198323;Reactome: R-HSA-6804759;Reactome: R-HSA-392451;Reactome: R-HSA-6804758;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-8948751;Reactome: R-HSA-389513;KEGG: 04151+2.7.11.1;Reactome: R-HSA-8876198;Reactome: R-HSA-69202;Reactome: R-HSA-111447;Reactome: R-HSA-199418	"Regulation of localization of FOXO transcription factors";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"CD28 dependent PI3K/Akt signaling";"Human cytomegalovirus infection";"mTOR signaling pathway";"TP53 Regulates Metabolic Genes";"Human papillomavirus infection";"PIP3 activates AKT signaling";"Downregulation of ERBB2:ERBB3 signaling";"AKT-mediated inactivation of FOXO1A";"Relaxin signaling pathway";"Constitutive Signaling by AKT1 E17K in Cancer";"Cyclin A:Cdk2-associated events at S phase entry";"RUNX2 regulates genes involved in cell migration";"AKT phosphorylates targets in the nucleus";"Thermogenesis";"Human immunodeficiency virus 1 infection";"AKT phosphorylates targets in the cytosol";"Regulation of TP53 Activity through Association with Co-factors";"G beta:gamma signalling through PI3Kgamma";"Regulation of TP53 Activity through Acetylation";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"Regulation of PTEN stability and activity";"CTLA4 inhibitory signaling";"PI3K-Akt signaling pathway";"RAB GEFs exchange GTP for GDP on RABs";"Cyclin E associated events during G1/S transition";"Activation of BAD and translocation to mitochondria";"Negative regulation of the PI3K/AKT network"
XP_053945225.1	3	Reactome: R-HSA-2514859;MetaCyc: PWY-7799;MetaCyc: PWY-7800	"Inactivation, recovery and regulation of the phototransduction cascade";"Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway"
XP_053961857.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053958235.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053959828.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053950203.1	10	Reactome: R-HSA-8939243;Reactome: R-HSA-445144;Reactome: R-HSA-8934903;Reactome: R-HSA-6814122;Reactome: R-HSA-2514853;Reactome: R-HSA-201688;Reactome: R-HSA-6804756;Reactome: R-HSA-8948751;Reactome: R-HSA-1483191;Reactome: R-HSA-6798695	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Signal transduction by L1";"Receptor Mediated Mitophagy";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Condensation of Prometaphase Chromosomes";"WNT mediated activation of DVL";"Regulation of TP53 Activity through Phosphorylation";"Regulation of PTEN stability and activity";"Synthesis of PC";"Neutrophil degranulation"
XP_053952075.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053969655.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_053961978.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053967346.1	2	Reactome: R-HSA-6807505;Reactome: R-HSA-72163	"RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway"
XP_053959009.1	16	Reactome: R-HSA-2467813;Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-174048;Reactome: R-HSA-176408;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-174184;Reactome: R-HSA-174084;Reactome: R-HSA-174154;Reactome: R-HSA-2559582;Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-174178;Reactome: R-HSA-176407;Reactome: R-HSA-176412	"Separation of Sister Chromatids";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Securin";"Senescence-Associated Secretory Phenotype (SASP)";"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Phosphorylation of the APC/C"
XP_053948319.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053953082.1	1	Reactome: R-HSA-1614558	"Degradation of cysteine and homocysteine"
XP_053951432.1	7	KEGG: 00010+1.2.4.1;KEGG: 00020+1.2.4.1;Reactome: R-HSA-5362517;Reactome: R-HSA-204174;Reactome: R-HSA-389661;Reactome: R-HSA-70268;KEGG: 00620+1.2.4.1	"Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)";"Signaling by Retinoic Acid";"Regulation of pyruvate dehydrogenase (PDH) complex";"Glyoxylate metabolism and glycine degradation";"Pyruvate metabolism";"Pyruvate metabolism"
XP_053949971.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053952384.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053962455.1	13	KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-7721;MetaCyc: PWY-6859;MetaCyc: PWY-6383;MetaCyc: PWY-5122;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7182;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7709;MetaCyc: PWY-5123	"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Linalool biosynthesis I";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis"
XP_053959773.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_053965840.1	6	Reactome: R-HSA-983712;Reactome: R-HSA-6798695;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"Ion channel transport";"Neutrophil degranulation";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1"
XP_053945373.1	3	Reactome: R-HSA-3214841;Reactome: R-HSA-6804760;Reactome: R-HSA-2299718	"PKMTs methylate histone lysines";"Regulation of TP53 Activity through Methylation";"Condensation of Prophase Chromosomes"
XP_053945925.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053952745.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053969516.1	10	Reactome: R-HSA-5628897;Reactome: R-HSA-163680;Reactome: R-HSA-9613354;Reactome: R-HSA-1632852;Reactome: R-HSA-2151209;Reactome: R-HSA-6804756;Reactome: R-HSA-200425;Reactome: R-HSA-9619483;Reactome: R-HSA-380972;Reactome: R-HSA-1445148	"TP53 Regulates Metabolic Genes";"AMPK inhibits chREBP transcriptional activation activity";"Lipophagy";"Macroautophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Regulation of TP53 Activity through Phosphorylation";"Carnitine metabolism";"Activation of AMPK downstream of NMDARs";"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053962843.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053958429.1	10	Reactome: R-HSA-162699;MetaCyc: PWY-7661;MetaCyc: PWY-7922;Reactome: R-HSA-4719377;MetaCyc: PWY-7979;Reactome: R-HSA-4719360;MetaCyc: PWY-7921;Reactome: R-HSA-4717374;KEGG: 00510+2.4.1.83;Reactome: R-HSA-913709	"Synthesis of dolichyl-phosphate mannose";"Protein N-glycosylation (Haloferax volcanii)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Protein O-mannosylation III (mammals, core M3)";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Protein O-mannosylation I (yeast)";"Defective DPM1 causes DPM1-CDG (CDG-1e)";"N-Glycan biosynthesis";"O-linked glycosylation of mucins"
XP_053950942.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_053962392.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053958422.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053958935.1	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
XP_053950903.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053968254.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_053953709.1	5	Reactome: R-HSA-937041;Reactome: R-HSA-937072;Reactome: R-HSA-936964;Reactome: R-HSA-166166;Reactome: R-HSA-168164	"IKK complex recruitment mediated by RIP1";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade"
XP_053955992.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053946374.1	9	Reactome: R-HSA-6804756;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776	"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape"
XP_053963845.1	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
XP_053970192.1	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
XP_053963453.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053967539.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053947136.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053960115.1	42	Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-9018519;Reactome: R-HSA-5334118;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-977225;Reactome: R-HSA-5693571;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-3214815;Reactome: R-HSA-5250924;Reactome: R-HSA-3214858;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-3214842;Reactome: R-HSA-2299718;Reactome: R-HSA-427413;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-5693607;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-1912408;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-110331;Reactome: R-HSA-427359;Reactome: R-HSA-5578749	"Meiotic recombination";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Estrogen-dependent gene expression";"DNA methylation";"Meiotic synapsis";"Packaging Of Telomere Ends";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Amyloid fiber formation";"Nonhomologous End-Joining (NHEJ)";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"HDACs deacetylate histones";"B-WICH complex positively regulates rRNA expression";"RMTs methylate histone arginines";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"HDMs demethylate histones";"Condensation of Prophase Chromosomes";"NoRC negatively regulates rRNA expression";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Processing of DNA double-strand break ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Pre-NOTCH Transcription and Translation";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Cleavage of the damaged purine";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs"
XP_053945776.1	2	Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_053961278.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053953702.1	5	Reactome: R-HSA-936964;Reactome: R-HSA-937041;Reactome: R-HSA-937072;Reactome: R-HSA-168164;Reactome: R-HSA-166166	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Toll Like Receptor 3 (TLR3) Cascade";"MyD88-independent TLR4 cascade"
XP_053969815.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_053959713.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053959834.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053963645.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_053947966.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053961250.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-110320	"Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH"
XP_053969576.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-77595;Reactome: R-HSA-159231;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway"
XP_053968022.1	2	Reactome: R-HSA-201722;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex"
XP_053960236.1	3	Reactome: R-HSA-9018519;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053949251.1	4	Reactome: R-HSA-6782315;Reactome: R-HSA-6787450;MetaCyc: PWY-2781;KEGG: 00908+2.5.1.75	"tRNA modification in the nucleus and cytosol";"tRNA modification in the mitochondrion";"Cis-zeatin biosynthesis";"Zeatin biosynthesis"
XP_053968029.1	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
XP_053948786.1	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_053961617.1	5	KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-7822;MetaCyc: PWY-6902	"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)"
XP_053960997.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053962609.1	5	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-6811434;Reactome: R-HSA-204005	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"COPI-dependent Golgi-to-ER retrograde traffic";"COPII-mediated vesicle transport"
XP_053961958.1	6	KEGG: 00500+2.4.1.18;MetaCyc: PWY-622;Reactome: R-HSA-189085;KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;MetaCyc: PWY-7900	"Starch and sucrose metabolism";"Starch biosynthesis";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)"
XP_053952347.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053962602.1	16	Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706	"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_053965640.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053969675.1	8	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-428540	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Activation of RAC1"
XP_053959641.1	33	Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-168333;Reactome: R-HSA-141444;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-5663220;Reactome: R-HSA-3301854;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-2467813;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-9648025;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-168325;Reactome: R-HSA-168276	"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"RHO GTPases Activate Formins";"Nuclear Pore Complex (NPC) Disassembly";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"Separation of Sister Chromatids";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways"
XP_053945716.1	14	MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199	"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation"
XP_053960175.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053965947.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053962584.1	7	Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-4615885;Reactome: R-HSA-68877	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase"
XP_053948383.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053955191.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_053950120.1	9	Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-1368108;Reactome: R-HSA-400206;Reactome: R-HSA-400253;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-191859	"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Regulation of lipid metabolism by PPARalpha";"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"snRNP Assembly"
XP_053963482.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053957546.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053965648.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053946307.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_053951594.1	6	Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156827	"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_053969443.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053952441.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053964010.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_053969855.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053961950.1	2	KEGG: 00983+3.6.1.23;KEGG: 00240+3.6.1.23	"Drug metabolism - other enzymes";"Pyrimidine metabolism"
XP_053950128.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_053959628.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053948791.1	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_053947255.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053945594.1	8	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Signaling by Hippo";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway"
XP_053951353.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053957489.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053961582.1	6	Reactome: R-HSA-181430;Reactome: R-HSA-388844;Reactome: R-HSA-210500;Reactome: R-HSA-181429;Reactome: R-HSA-212676;Reactome: R-HSA-264642	"Norepinephrine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Glutamate Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle"
XP_053959227.1	22	Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-5673000;Reactome: R-HSA-196299;Reactome: R-HSA-2500257;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-5358747;Reactome: R-HSA-6811558;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-432142;Reactome: R-HSA-389513;Reactome: R-HSA-141444	"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RAF activation";"Beta-catenin phosphorylation cascade";"Resolution of Sister Chromatid Cohesion";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S33 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_053948433.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053950730.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053961918.1	6	MetaCyc: PWY-4381;MetaCyc: PWY-6722;MetaCyc: PWY-5744;Reactome: R-HSA-196780;MetaCyc: PWY-5789;MetaCyc: PWY-5743	"Fatty acid biosynthesis initiation (bacteria and plants)";"Candicidin biosynthesis";"Glyoxylate assimilation";"Biotin transport and metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"3-hydroxypropanoate cycle"
XP_053962034.1	2	Reactome: R-HSA-6802953;Reactome: R-HSA-5658442	"RAS signaling downstream of NF1 loss-of-function variants";"Regulation of RAS by GAPs"
XP_053961863.1	2	Reactome: R-HSA-8873719;Reactome: R-HSA-8876198	"RAB geranylgeranylation";"RAB GEFs exchange GTP for GDP on RABs"
XP_053966171.1	6	Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids"
XP_053948379.1	15	Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-167242;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-113418;Reactome: R-HSA-9603505;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-167152	"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"Formation of the Early Elongation Complex";"NTRK3 as a dependence receptor";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat"
XP_053964058.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053964932.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
XP_053955186.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053951756.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053946897.1	6	KEGG: 00510+2.4.1.143;MetaCyc: PWY-7920;MetaCyc: PWY-7426;KEGG: 00513+2.4.1.143;Reactome: R-HSA-975578;Reactome: R-HSA-4793952	"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (plants)";"Complex N-linked glycan biosynthesis (vertebrates)";"Various types of N-glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)"
XP_053964939.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_053945379.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053959772.1	19	KEGG: 00020+1.1.1.37;MetaCyc: PWY-5913;Reactome: R-HSA-71403;MetaCyc: PWY-7115;MetaCyc: PWY-6728;KEGG: 00620+1.1.1.37;KEGG: 00710+1.1.1.37;KEGG: 00270+1.1.1.37;MetaCyc: PWY-561;Reactome: R-HSA-70263;MetaCyc: PWY-8086;KEGG: 00630+1.1.1.37;MetaCyc: PWY-6969;MetaCyc: PWY-5392;KEGG: 00720+1.1.1.37;MetaCyc: PWY-1622;KEGG: 00680+1.1.1.37;MetaCyc: PWY-7383;MetaCyc: PWY-5690	"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Citric acid cycle (TCA cycle)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Methylaspartate cycle";"Pyruvate metabolism";"Carbon fixation in photosynthetic organisms";"Cysteine and methionine metabolism";"Superpathway of glyoxylate cycle and fatty acid degradation";"Gluconeogenesis";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Glyoxylate and dicarboxylate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"TCA cycle II (plants and fungi)"
XP_053959779.1	2	Reactome: R-HSA-390918;Reactome: R-HSA-9033241	"Peroxisomal lipid metabolism";"Peroxisomal protein import"
XP_053945372.1	3	Reactome: R-HSA-2299718;Reactome: R-HSA-6804760;Reactome: R-HSA-3214841	"Condensation of Prophase Chromosomes";"Regulation of TP53 Activity through Methylation";"PKMTs methylate histone lysines"
XP_053949996.1	5	Reactome: R-HSA-5218920;Reactome: R-HSA-1257604;Reactome: R-HSA-389357;Reactome: R-HSA-6804757;Reactome: R-HSA-5674400	"VEGFR2 mediated vascular permeability";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling";"Regulation of TP53 Degradation";"Constitutive Signaling by AKT1 E17K in Cancer"
XP_053962842.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053963395.1	6	Reactome: R-HSA-1268020;KEGG: 00190+7.1.2.2;Reactome: R-HSA-8949613;MetaCyc: PWY-7980;Reactome: R-HSA-163210;KEGG: 00195+7.1.2.2	"Mitochondrial protein import";"Oxidative phosphorylation";"Cristae formation";"ATP biosynthesis";"Formation of ATP by chemiosmotic coupling";"Photosynthesis"
XP_053951372.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053951433.1	7	Reactome: R-HSA-389661;Reactome: R-HSA-204174;Reactome: R-HSA-70268;KEGG: 00010+1.2.4.1;Reactome: R-HSA-5362517;KEGG: 00020+1.2.4.1;KEGG: 00620+1.2.4.1	"Glyoxylate metabolism and glycine degradation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Signaling by Retinoic Acid";"Citrate cycle (TCA cycle)";"Pyruvate metabolism"
XP_053953083.1	5	KEGG: 00564+2.7.7.41;MetaCyc: PWY-5981;MetaCyc: PWY-7817;MetaCyc: PWY-5667;KEGG: 04070+2.7.7.41	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Type I lipoteichoic acid biosynthesis (S. aureus)";"CDP-diacylglycerol biosynthesis I";"Phosphatidylinositol signaling system"
XP_053965274.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_053968247.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_053961280.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053946434.1	2	Reactome: R-HSA-5578999;Reactome: R-HSA-174403	"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Glutathione synthesis and recycling"
XP_053970193.1	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
XP_053955993.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053964538.1	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
XP_053966518.1	6	Reactome: R-HSA-399997;Reactome: R-HSA-456926;Reactome: R-HSA-428930;Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-416476	"Acetylcholine regulates insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"G alpha (q) signalling events"
XP_053953703.1	5	Reactome: R-HSA-168164;Reactome: R-HSA-166166;Reactome: R-HSA-936964;Reactome: R-HSA-937072;Reactome: R-HSA-937041	"Toll Like Receptor 3 (TLR3) Cascade";"MyD88-independent TLR4 cascade";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IKK complex recruitment mediated by RIP1"
XP_053953224.1	12	MetaCyc: PWY-7817;MetaCyc: PWY-7343;KEGG: 00040+2.7.7.9;MetaCyc: PWY-3801;KEGG: 00052+2.7.7.9;KEGG: 00500+2.7.7.9;MetaCyc: PWY-7238;KEGG: 00561+2.7.7.9;MetaCyc: PWY-6527;Reactome: R-HSA-173599;KEGG: 00520+2.7.7.9;Reactome: R-HSA-3322077	"Type I lipoteichoic acid biosynthesis (S. aureus)";"UDP-alpha-D-glucose biosynthesis I";"Pentose and glucuronate interconversions";"Sucrose degradation II (sucrose synthase)";"Galactose metabolism";"Starch and sucrose metabolism";"Sucrose biosynthesis II";"Glycerolipid metabolism";"Stachyose degradation";"Formation of the active cofactor, UDP-glucuronate";"Amino sugar and nucleotide sugar metabolism";"Glycogen synthesis"
XP_053953749.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053964700.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053952697.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053950909.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053966273.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053950902.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053967160.1	6	MetaCyc: PWY-7285;MetaCyc: PWY-6829;Reactome: R-HSA-6787450;MetaCyc: PWY-7286;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470	"Methylwyosine biosynthesis";"Trna methylation (yeast)";"tRNA modification in the mitochondrion";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion"
XP_053962393.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053952636.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_053964708.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053952374.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053957805.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053967703.1	30	Reactome: R-HSA-199418;Reactome: R-HSA-69202;Reactome: R-HSA-111447;Reactome: R-HSA-8876198;KEGG: 04151+2.7.11.1;Reactome: R-HSA-389513;Reactome: R-HSA-8948751;Reactome: R-HSA-6804757;Reactome: R-HSA-6804758;Reactome: R-HSA-5218920;Reactome: R-HSA-392451;Reactome: R-HSA-6804759;Reactome: R-HSA-198323;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-8941332;Reactome: R-HSA-198693;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5674400;Reactome: R-HSA-69656;Reactome: R-HSA-211163;Reactome: R-HSA-1257604;Reactome: R-HSA-1358803;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-9634638;Reactome: R-HSA-9614399	"Negative regulation of the PI3K/AKT network";"Cyclin E associated events during G1/S transition";"Activation of BAD and translocation to mitochondria";"RAB GEFs exchange GTP for GDP on RABs";"PI3K-Akt signaling pathway";"CTLA4 inhibitory signaling";"Regulation of PTEN stability and activity";"Regulation of TP53 Degradation";"Regulation of TP53 Activity through Acetylation";"VEGFR2 mediated vascular permeability";"G beta:gamma signalling through PI3Kgamma";"Regulation of TP53 Activity through Association with Co-factors";"AKT phosphorylates targets in the cytosol";"Thermogenesis";"Human immunodeficiency virus 1 infection";"RUNX2 regulates genes involved in cell migration";"AKT phosphorylates targets in the nucleus";"Relaxin signaling pathway";"Constitutive Signaling by AKT1 E17K in Cancer";"Cyclin A:Cdk2-associated events at S phase entry";"AKT-mediated inactivation of FOXO1A";"PIP3 activates AKT signaling";"Downregulation of ERBB2:ERBB3 signaling";"Human papillomavirus infection";"TP53 Regulates Metabolic Genes";"mTOR signaling pathway";"Human cytomegalovirus infection";"CD28 dependent PI3K/Akt signaling";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Regulation of localization of FOXO transcription factors"
XP_053967749.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053966510.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053951383.1	6	Reactome: R-HSA-400253;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-2173788;Reactome: R-HSA-163560	"Circadian Clock";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Downregulation of TGF-beta receptor signaling";"Triglyceride catabolism"
XP_053953533.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053961095.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053949824.1	3	Reactome: R-HSA-5423646;Reactome: R-HSA-5579007;KEGG: 00220+3.5.1.14	"Aflatoxin activation and detoxification";"Defective ACY1 causes encephalopathy";"Arginine biosynthesis"
XP_053959497.1	13	KEGG: 00983+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7226;MetaCyc: PWY-7184;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7220;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7222;MetaCyc: PWY-7198;MetaCyc: PWY-7227;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7210	"Drug metabolism - other enzymes";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Purine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP"
XP_053956826.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053961980.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053967896.1	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
XP_053966289.1	2	Reactome: R-HSA-202433;Reactome: R-HSA-376176	"Generation of second messenger molecules";"Signaling by ROBO receptors"
XP_053949630.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053967306.1	11	Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-418594;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-418597	"G alpha (s) signalling events";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Glucagon signaling in metabolic regulation";"G alpha (i) signalling events";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"G alpha (z) signalling events"
XP_053955156.1	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-8876198	"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"RAB GEFs exchange GTP for GDP on RABs"
XP_053959049.1	2	Reactome: R-HSA-72764;Reactome: R-HSA-156581	"Eukaryotic Translation Termination";"Methylation"
XP_053962001.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_053966558.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053966325.1	4	Reactome: R-HSA-6814122;Reactome: R-HSA-112043;Reactome: R-HSA-418594;Reactome: R-HSA-202040	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"PLC beta mediated events";"G alpha (i) signalling events";"G-protein activation"
XP_053961552.1	6	Reactome: R-HSA-381426;Reactome: R-HSA-201722;Reactome: R-HSA-2173796;Reactome: R-HSA-5626467;Reactome: R-HSA-3769402;Reactome: R-HSA-8957275	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Formation of the beta-catenin:TCF transactivating complex";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"RHO GTPases activate IQGAPs";"Deactivation of the beta-catenin transactivating complex";"Post-translational protein phosphorylation"
XP_053955165.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_053946384.1	5	Reactome: R-HSA-73621;Reactome: R-HSA-73614;KEGG: 00983+2.4.2.3;MetaCyc: PWY-5532;KEGG: 00240+2.4.2.3	"Pyrimidine catabolism";"Pyrimidine salvage";"Drug metabolism - other enzymes";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine metabolism"
XP_053949937.1	5	KEGG: 00720+1.5.1.20;MetaCyc: PWY-3841;Reactome: R-HSA-196757;MetaCyc: PWY-2201;KEGG: 00670+1.5.1.20	"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Metabolism of folate and pterines";"Folate transformations I";"One carbon pool by folate"
XP_053961631.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053965022.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_053950202.1	10	Reactome: R-HSA-8939243;Reactome: R-HSA-445144;Reactome: R-HSA-8934903;Reactome: R-HSA-6814122;Reactome: R-HSA-2514853;Reactome: R-HSA-201688;Reactome: R-HSA-6804756;Reactome: R-HSA-8948751;Reactome: R-HSA-1483191;Reactome: R-HSA-6798695	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Signal transduction by L1";"Receptor Mediated Mitophagy";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Condensation of Prometaphase Chromosomes";"WNT mediated activation of DVL";"Regulation of TP53 Activity through Phosphorylation";"Regulation of PTEN stability and activity";"Synthesis of PC";"Neutrophil degranulation"
XP_053961043.1	4	MetaCyc: PWY-5912;MetaCyc: PWY-5041;Reactome: R-HSA-156581;KEGG: 00270+2.5.1.6	"2'-deoxymugineic acid phytosiderophore biosynthesis";"S-adenosyl-L-methionine cycle II";"Methylation";"Cysteine and methionine metabolism"
XP_053945666.1	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
XP_053953240.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053951655.1	5	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport"
XP_053966822.1	8	Reactome: R-HSA-111458;Reactome: R-HSA-8953750;Reactome: R-HSA-6803207;Reactome: R-HSA-111459;Reactome: R-HSA-111464;Reactome: R-HSA-111463;Reactome: R-HSA-6798695;Reactome: R-HSA-9627069	"Formation of apoptosome";"Transcriptional Regulation by E2F6";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Activation of caspases through apoptosome-mediated cleavage";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"SMAC (DIABLO) binds to IAPs";"Neutrophil degranulation";"Regulation of the apoptosome activity"
XP_053961828.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053966008.1	8	Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-68616;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68867	"Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the pre-replicative complex"
XP_053945655.1	1	Reactome: R-HSA-196836	"Vitamin C (ascorbate) metabolism"
XP_053959857.1	4	Reactome: R-HSA-8939211;Reactome: R-HSA-3371497;Reactome: R-HSA-3371568;Reactome: R-HSA-9018519	"ESR-mediated signaling";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Attenuation phase";"Estrogen-dependent gene expression"
XP_053962639.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053959553.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053967456.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053951666.1	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
XP_053945565.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053955026.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053946793.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_053969382.1	2	Reactome: R-HSA-5683371;Reactome: R-HSA-1369007	"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)";"Mitochondrial ABC transporters"
XP_053969367.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053951556.1	14	KEGG: 00561+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;MetaCyc: PWY-6453;MetaCyc: PWY-7589;MetaCyc: PWY-7411;MetaCyc: PWY-8053;MetaCyc: PWY-5667;MetaCyc: PWY-7417;KEGG: 00564+2.3.1.51	"Glycerolipid metabolism";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism"
XP_053966788.1	83	Reactome: R-HSA-210993;Reactome: R-HSA-5654712;Reactome: R-HSA-8865999;Reactome: R-HSA-9645135;Reactome: R-HSA-5654706;Reactome: R-HSA-8853338;Reactome: R-HSA-1433559;Reactome: R-HSA-391160;Reactome: R-HSA-389359;Reactome: R-HSA-5663213;Reactome: R-HSA-74751;Reactome: R-HSA-912631;Reactome: R-HSA-5654710;Reactome: R-HSA-2424491;Reactome: R-HSA-6811558;Reactome: R-HSA-112412;Reactome: R-HSA-5654693;Reactome: R-HSA-5654700;Reactome: R-HSA-983695;Reactome: R-HSA-8875555;Reactome: R-HSA-8983432;Reactome: R-HSA-74749;Reactome: R-HSA-9028731;Reactome: R-HSA-2428933;Reactome: R-HSA-9027284;Reactome: R-HSA-8856825;Reactome: R-HSA-5654732;Reactome: R-HSA-5655253;Reactome: R-HSA-8851907;Reactome: R-HSA-8853659;Reactome: R-HSA-109704;Reactome: R-HSA-2179392;Reactome: R-HSA-186763;Reactome: R-HSA-2871796;Reactome: R-HSA-5655302;Reactome: R-HSA-8875656;Reactome: R-HSA-1839117;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-2219530;Reactome: R-HSA-512988;Reactome: R-HSA-5654726;Reactome: R-HSA-5655291;Reactome: R-HSA-1963640;Reactome: R-HSA-5654727;Reactome: R-HSA-8856828;Reactome: R-HSA-1433557;Reactome: R-HSA-2871809;Reactome: R-HSA-5654704;Reactome: R-HSA-8853334;Reactome: R-HSA-1963642;Reactome: R-HSA-912526;Reactome: R-HSA-9026519;Reactome: R-HSA-2029482;Reactome: R-HSA-2730905;Reactome: R-HSA-167044;Reactome: R-HSA-5654719;Reactome: R-HSA-5654699;Reactome: R-HSA-5637810;Reactome: R-HSA-9607240;Reactome: R-HSA-5654720;Reactome: R-HSA-9634285;Reactome: R-HSA-179812;Reactome: R-HSA-1295596;Reactome: R-HSA-9028335;Reactome: R-HSA-6807004;Reactome: R-HSA-388841;Reactome: R-HSA-1257604;Reactome: R-HSA-9034864;Reactome: R-HSA-1250196;Reactome: R-HSA-182971;Reactome: R-HSA-1236382;Reactome: R-HSA-5654688;Reactome: R-HSA-1250347;Reactome: R-HSA-9664565;Reactome: R-HSA-354194;Reactome: R-HSA-5654695;Reactome: R-HSA-8875360;Reactome: R-HSA-180336;Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-180292;Reactome: R-HSA-8851805	"Tie2 Signaling";"FRS-mediated FGFR4 signaling";"MET activates PTPN11";"STAT5 Activation";"FRS-mediated FGFR3 signaling";"Signaling by FGFR3 point mutants in cancer";"Regulation of KIT signaling";"Signal regulatory protein family interactions";"CD28 dependent Vav1 pathway";"RHO GTPases Activate WASPs and WAVEs";"Insulin receptor signalling cascade";"Regulation of signaling by CBL";"PI-3K cascade:FGFR3";"DAP12 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SOS-mediated signalling";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR2 signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"MET activates RAP1 and RAC1";"Interleukin-15 signaling";"Signal attenuation";"Activated NTRK2 signals through FRS2 and FRS3";"SHC-related events triggered by IGF1R";"Erythropoietin activates RAS";"Cargo recognition for clathrin-mediated endocytosis";"Negative regulation of FGFR3 signaling";"Signaling by FGFR2 in disease";"MET activates PI3K/AKT signaling";"RET signaling";"PI3K Cascade";"EGFR Transactivation by Gastrin";"Downstream signal transduction";"FCERI mediated MAPK activation";"Signaling by FGFR1 in disease";"MET receptor recycling";"Signaling by cytosolic FGFR1 fusion mutants";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Negative regulation of FGFR1 signaling";"Signaling by FGFR4 in disease";"GRB2 events in ERBB2 signaling";"Negative regulation of FGFR2 signaling";"Clathrin-mediated endocytosis";"Signaling by SCF-KIT";"FCERI mediated Ca+2 mobilization";"SHC-mediated cascade:FGFR3";"Signaling by FGFR3 fusions in cancer";"PI3K events in ERBB2 signaling";"Interleukin receptor SHC signaling";"Activated NTRK2 signals through RAS";"Regulation of actin dynamics for phagocytic cup formation";"Role of LAT2/NTAL/LAB on calcium mobilization";"Signalling to RAS";"SHC-mediated cascade:FGFR4";"SHC-mediated cascade:FGFR2";"Constitutive Signaling by EGFRvIII";"FLT3 Signaling";"PI-3K cascade:FGFR4";"Constitutive Signaling by Overexpressed ERBB2";"GRB2 events in EGFR signaling";"Spry regulation of FGF signaling";"Activated NTRK2 signals through PI3K";"Negative regulation of MET activity";"Costimulation by the CD28 family";"PIP3 activates AKT signaling";"Activated NTRK3 signals through RAS";"SHC1 events in ERBB2 signaling";"EGFR downregulation";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"SHC-mediated cascade:FGFR1";"SHC1 events in ERBB4 signaling";"Signaling by ERBB2 KD Mutants";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"PI-3K cascade:FGFR2";"InlB-mediated entry of Listeria monocytogenes into host cell";"SHC1 events in EGFR signaling";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"GAB1 signalosome";"MET activates RAS signaling"
XP_053959270.1	22	Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-5358747;Reactome: R-HSA-196299;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5673000;Reactome: R-HSA-2500257;Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-5663220;Reactome: R-HSA-195253;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-432142;Reactome: R-HSA-6811558;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-5358751;Reactome: R-HSA-68877	"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S33 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"RAF activation";"Resolution of Sister Chromatid Cohesion";"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"RHO GTPases Activate Formins";"Degradation of beta-catenin by the destruction complex";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Platelet sensitization by LDL";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase"
XP_053969389.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053950163.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_053954348.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053957309.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053949284.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053950530.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053962017.1	2	MetaCyc: PWY-6281;KEGG: 00450+2.7.9.3	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocompound metabolism"
XP_053946806.1	4	KEGG: 00520+2.7.1.59;Reactome: R-HSA-446210;MetaCyc: PWY-6517;MetaCyc: PWY-6906	"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"N-acetylglucosamine degradation II";"Chitin derivatives degradation"
XP_053950708.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053951565.1	14	MetaCyc: PWY-7417;MetaCyc: PWY-5667;MetaCyc: PWY-8053;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-5981;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-7411;MetaCyc: PWY-7587;MetaCyc: PWY-8055;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.51	"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis II";"Glycerophospholipid metabolism";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis III";"Synthesis of PA";"Plasmalogen biosynthesis";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism"
XP_053953416.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053966780.1	83	Reactome: R-HSA-9028335;Reactome: R-HSA-6807004;Reactome: R-HSA-388841;Reactome: R-HSA-1257604;Reactome: R-HSA-1236382;Reactome: R-HSA-182971;Reactome: R-HSA-9034864;Reactome: R-HSA-1250196;Reactome: R-HSA-1250347;Reactome: R-HSA-9664565;Reactome: R-HSA-5654688;Reactome: R-HSA-8875360;Reactome: R-HSA-354194;Reactome: R-HSA-5654695;Reactome: R-HSA-180336;Reactome: R-HSA-8851805;Reactome: R-HSA-5673001;Reactome: R-HSA-180292;Reactome: R-HSA-375165;Reactome: R-HSA-1963640;Reactome: R-HSA-5654726;Reactome: R-HSA-5655291;Reactome: R-HSA-1433557;Reactome: R-HSA-8856828;Reactome: R-HSA-5654727;Reactome: R-HSA-5654704;Reactome: R-HSA-2871809;Reactome: R-HSA-912526;Reactome: R-HSA-8853334;Reactome: R-HSA-1963642;Reactome: R-HSA-2029482;Reactome: R-HSA-9026519;Reactome: R-HSA-5637810;Reactome: R-HSA-5654699;Reactome: R-HSA-5654719;Reactome: R-HSA-167044;Reactome: R-HSA-2730905;Reactome: R-HSA-1295596;Reactome: R-HSA-179812;Reactome: R-HSA-9634285;Reactome: R-HSA-5654720;Reactome: R-HSA-9607240;Reactome: R-HSA-9028731;Reactome: R-HSA-74749;Reactome: R-HSA-5654732;Reactome: R-HSA-8856825;Reactome: R-HSA-9027284;Reactome: R-HSA-2428933;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-8853659;Reactome: R-HSA-5655253;Reactome: R-HSA-8851907;Reactome: R-HSA-186763;Reactome: R-HSA-2871796;Reactome: R-HSA-8875656;Reactome: R-HSA-5655302;Reactome: R-HSA-512988;Reactome: R-HSA-2219530;Reactome: R-HSA-5654733;Reactome: R-HSA-5654689;Reactome: R-HSA-1839117;Reactome: R-HSA-9645135;Reactome: R-HSA-8865999;Reactome: R-HSA-5654712;Reactome: R-HSA-210993;Reactome: R-HSA-8853338;Reactome: R-HSA-5654706;Reactome: R-HSA-912631;Reactome: R-HSA-74751;Reactome: R-HSA-389359;Reactome: R-HSA-391160;Reactome: R-HSA-5663213;Reactome: R-HSA-1433559;Reactome: R-HSA-5654710;Reactome: R-HSA-2424491;Reactome: R-HSA-8875555;Reactome: R-HSA-983695;Reactome: R-HSA-5654700;Reactome: R-HSA-5654693;Reactome: R-HSA-6811558;Reactome: R-HSA-112412;Reactome: R-HSA-8983432	"Activated NTRK2 signals through PI3K";"Negative regulation of MET activity";"Costimulation by the CD28 family";"PIP3 activates AKT signaling";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"EGFR downregulation";"Activated NTRK3 signals through RAS";"SHC1 events in ERBB2 signaling";"SHC1 events in ERBB4 signaling";"Signaling by ERBB2 KD Mutants";"SHC-mediated cascade:FGFR1";"InlB-mediated entry of Listeria monocytogenes into host cell";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"PI-3K cascade:FGFR2";"SHC1 events in EGFR signaling";"MET activates RAS signaling";"RAF/MAP kinase cascade";"GAB1 signalosome";"NCAM signaling for neurite out-growth";"GRB2 events in ERBB2 signaling";"Negative regulation of FGFR1 signaling";"Signaling by FGFR4 in disease";"Signaling by SCF-KIT";"Clathrin-mediated endocytosis";"Negative regulation of FGFR2 signaling";"SHC-mediated cascade:FGFR3";"FCERI mediated Ca+2 mobilization";"Interleukin receptor SHC signaling";"Signaling by FGFR3 fusions in cancer";"PI3K events in ERBB2 signaling";"Regulation of actin dynamics for phagocytic cup formation";"Activated NTRK2 signals through RAS";"Constitutive Signaling by EGFRvIII";"SHC-mediated cascade:FGFR2";"SHC-mediated cascade:FGFR4";"Signalling to RAS";"Role of LAT2/NTAL/LAB on calcium mobilization";"Spry regulation of FGF signaling";"GRB2 events in EGFR signaling";"Constitutive Signaling by Overexpressed ERBB2";"PI-3K cascade:FGFR4";"FLT3 Signaling";"Activated NTRK2 signals through FRS2 and FRS3";"Signal attenuation";"Negative regulation of FGFR3 signaling";"Cargo recognition for clathrin-mediated endocytosis";"Erythropoietin activates RAS";"SHC-related events triggered by IGF1R";"EGFR Transactivation by Gastrin";"PI3K Cascade";"RET signaling";"Signaling by FGFR2 in disease";"MET activates PI3K/AKT signaling";"Downstream signal transduction";"FCERI mediated MAPK activation";"MET receptor recycling";"Signaling by FGFR1 in disease";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Negative regulation of FGFR4 signaling";"PI-3K cascade:FGFR1";"Signaling by cytosolic FGFR1 fusion mutants";"STAT5 Activation";"MET activates PTPN11";"FRS-mediated FGFR4 signaling";"Tie2 Signaling";"Signaling by FGFR3 point mutants in cancer";"FRS-mediated FGFR3 signaling";"Regulation of signaling by CBL";"Insulin receptor signalling cascade";"CD28 dependent Vav1 pathway";"Signal regulatory protein family interactions";"RHO GTPases Activate WASPs and WAVEs";"Regulation of KIT signaling";"PI-3K cascade:FGFR3";"DAP12 signaling";"MET activates RAP1 and RAC1";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"FRS-mediated FGFR2 signaling";"FRS-mediated FGFR1 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SOS-mediated signalling";"Interleukin-15 signaling"
XP_053961634.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053967948.1	3	Reactome: R-HSA-174403;MetaCyc: PWY-7942;KEGG: 00480+4.3.2.7	"Glutathione synthesis and recycling";"5-oxo-L-proline metabolism";"Glutathione metabolism"
XP_053946381.1	5	KEGG: 00983+2.4.2.3;Reactome: R-HSA-73614;Reactome: R-HSA-73621;KEGG: 00240+2.4.2.3;MetaCyc: PWY-5532	"Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine catabolism";"Pyrimidine metabolism";"Nucleoside and nucleotide degradation (archaea)"
XP_053950700.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_053959513.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053962511.1	5	KEGG: 00010+4.1.1.32;MetaCyc: PWY-7383;Reactome: R-HSA-70263;KEGG: 00020+4.1.1.32;KEGG: 00620+4.1.1.32	"Glycolysis / Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Gluconeogenesis";"Citrate cycle (TCA cycle)";"Pyruvate metabolism"
XP_053963343.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_053958194.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_053949821.1	56	Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-174154;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-202424;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-174184	"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"APC/C:Cdc20 mediated degradation of Securin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of AXIN";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"Downstream TCR signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
XP_053970145.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053961841.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053951875.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_053945875.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053946337.1	11	Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-167200	"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat"
XP_053949984.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_053952371.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053962057.1	3	Reactome: R-HSA-525793;Reactome: R-HSA-5663220;Reactome: R-HSA-9634638	"Myogenesis";"RHO GTPases Activate Formins";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling"
XP_053965112.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_053956291.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053950995.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_053950939.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053958945.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053955194.1	8	Reactome: R-HSA-5620912;Reactome: R-HSA-6798695;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-380270	"Anchoring of the basal body to the plasma membrane";"Neutrophil degranulation";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes"
XP_053959583.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_053950932.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_053946404.1	9	MetaCyc: PWY-5743;MetaCyc: PWY-7115;MetaCyc: PWY-5789;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-241;MetaCyc: PWY-5744;Reactome: R-HSA-1475029;MetaCyc: PWY-7117	"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Glyoxylate assimilation";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type"
XP_053946311.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_053962178.1	2	MetaCyc: PWY-5905;Reactome: R-HSA-204626	"Hypusine biosynthesis";"Hypusine synthesis from eIF5A-lysine"
XP_053967549.1	6	Reactome: R-HSA-191273;MetaCyc: PWY-6174;MetaCyc: PWY-7391;Reactome: R-HSA-2426168;KEGG: 00900+2.7.1.36;MetaCyc: PWY-922	"Cholesterol biosynthesis";"Mevalonate pathway II (archaea)";"Isoprene biosynthesis II (engineered)";"Activation of gene expression by SREBF (SREBP)";"Terpenoid backbone biosynthesis";"Mevalonate pathway I"
XP_053967503.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_053966710.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053967807.1	2	Reactome: R-HSA-446199;Reactome: R-HSA-4755609	"Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59"
XP_053960470.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053956256.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
XP_053945586.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
XP_053967397.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_053966623.1	33	Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-8939236;Reactome: R-HSA-5696395;Reactome: R-HSA-69656;Reactome: R-HSA-75953;Reactome: R-HSA-69231;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-6781823;Reactome: R-HSA-73776;Reactome: R-HSA-73863;Reactome: R-HSA-72086;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-77075;Reactome: R-HSA-76042;Reactome: R-HSA-427413;Reactome: R-HSA-69202;Reactome: R-HSA-75955;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-167162;Reactome: R-HSA-73762;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-69273;Reactome: R-HSA-112382;Reactome: R-HSA-167161;Reactome: R-HSA-73772	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Formation of Incision Complex in GG-NER";"Cyclin A:Cdk2-associated events at S phase entry";"RNA Polymerase II Transcription Initiation";"Cyclin D associated events in G1";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Termination";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"NoRC negatively regulates rRNA expression";"Cyclin E associated events during G1/S transition";"RNA Polymerase II Transcription Elongation";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Cyclin A/B1/B2 associated events during G2/M transition";"Formation of RNA Pol II elongation complex";"HIV Transcription Initiation";"RNA Polymerase I Promoter Escape"
XP_053965167.1	11	Reactome: R-HSA-4420332;Reactome: R-HSA-1971475;Reactome: R-HSA-3656253;Reactome: R-HSA-3000170;Reactome: R-HSA-3560801;Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-2024096;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;Reactome: R-HSA-3560783	"Defective B3GALT6 causes EDSP2 and SEMDJL1";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Syndecan interactions";"Defective B3GAT3 causes JDSSDHD";"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"HS-GAG degradation";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Defective B4GALT7 causes EDS, progeroid type"
XP_053958460.1	182	Reactome: R-HSA-937039;Reactome: R-HSA-9013973;Reactome: R-HSA-1253288;Reactome: R-HSA-9020702;Reactome: R-HSA-72695;Reactome: R-HSA-5684264;Reactome: R-HSA-400253;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-5696394;Reactome: R-HSA-975956;Reactome: R-HSA-195253;Reactome: R-HSA-168928;Reactome: R-HSA-9645460;Reactome: R-HSA-5656121;Reactome: R-HSA-110314;Reactome: R-HSA-936964;Reactome: R-HSA-174184;Reactome: R-HSA-5685942;Reactome: R-HSA-975110;Reactome: R-HSA-450321;Reactome: R-HSA-2559580;Reactome: R-HSA-6783310;Reactome: R-HSA-174490;Reactome: R-HSA-202424;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-3769402;Reactome: R-HSA-5607764;Reactome: R-HSA-5656169;Reactome: R-HSA-72706;Reactome: R-HSA-8854050;Reactome: R-HSA-5696397;Reactome: R-HSA-8951664;Reactome: R-HSA-5689603;Reactome: R-HSA-2173795;Reactome: R-HSA-2173788;Reactome: R-HSA-8876493;Reactome: R-HSA-6791226;Reactome: R-HSA-180585;Reactome: R-HSA-156827;Reactome: R-HSA-6804757;Reactome: R-HSA-205043;Reactome: R-HSA-6804756;Reactome: R-HSA-8866652;Reactome: R-HSA-6807004;Reactome: R-HSA-1358803;Reactome: R-HSA-5687128;Reactome: R-HSA-182971;Reactome: R-HSA-445989;Reactome: R-HSA-8948747;Reactome: R-HSA-532668;Reactome: R-HSA-4608870;Reactome: R-HSA-8875360;Reactome: R-HSA-450408;Reactome: R-HSA-8849469;Reactome: R-HSA-8941858;Reactome: R-HSA-975163;Reactome: R-HSA-69017;Reactome: R-HSA-211733;Reactome: R-HSA-5654726;Reactome: R-HSA-162588;Reactome: R-HSA-5654727;Reactome: R-HSA-6781823;Reactome: R-HSA-174154;Reactome: R-HSA-5689901;Reactome: R-HSA-6781827;Reactome: R-HSA-69541;Reactome: R-HSA-9033241;Reactome: R-HSA-69601;Reactome: R-HSA-5689877;Reactome: R-HSA-1236974;Reactome: R-HSA-5658442;Reactome: R-HSA-4641263;Reactome: R-HSA-5654732;Reactome: R-HSA-2565942;Reactome: R-HSA-2173791;Reactome: R-HSA-9636383;Reactome: R-HSA-9613829;Reactome: R-HSA-2122948;Reactome: R-HSA-977225;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-156902;Reactome: R-HSA-174084;Reactome: R-HSA-5610785;Reactome: R-HSA-3322077;Reactome: R-HSA-450302;Reactome: R-HSA-4641258;Reactome: R-HSA-175474;Reactome: R-HSA-9637628;Reactome: R-HSA-5610780;Reactome: R-HSA-179409;Reactome: R-HSA-72689;Reactome: R-HSA-3134975;Reactome: R-HSA-174178;Reactome: R-HSA-110320;Reactome: R-HSA-9646399;Reactome: R-HSA-1799339;Reactome: R-HSA-937041;Reactome: R-HSA-5610783;Reactome: R-HSA-187577;Reactome: R-HSA-8866654;Reactome: R-HSA-1169408;Reactome: R-HSA-8856828;Reactome: R-HSA-68827;Reactome: R-HSA-983168;Reactome: R-HSA-917937;Reactome: R-HSA-168927;Reactome: R-HSA-3785653;Reactome: R-HSA-8856825;Reactome: R-HSA-5668541;Reactome: R-HSA-2559582;Reactome: R-HSA-8939236;Reactome: R-HSA-937042;Reactome: R-HSA-2979096;Reactome: R-HSA-2672351;Reactome: R-HSA-901032;Reactome: R-HSA-168638;Reactome: R-HSA-69231;Reactome: R-HSA-2871837;Reactome: R-HSA-2122947;Reactome: R-HSA-349425;Reactome: R-HSA-174048;Reactome: R-HSA-8863795;Reactome: R-HSA-5362768;Reactome: R-HSA-975144;Reactome: R-HSA-110312;Reactome: R-HSA-68949;Reactome: R-HSA-2691232;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-382556;Reactome: R-HSA-5696395;Reactome: R-HSA-2173796;Reactome: R-HSA-1236382;Reactome: R-HSA-9633012;Reactome: R-HSA-180534;Reactome: R-HSA-5655862;Reactome: R-HSA-8939902;Reactome: R-HSA-5675221;Reactome: R-HSA-917729;Reactome: R-HSA-6782135;Reactome: R-HSA-5357956;Reactome: R-HSA-1169091;Reactome: R-HSA-69481;Reactome: R-HSA-72649;Reactome: R-HSA-2559585;Reactome: R-HSA-201681;Reactome: R-HSA-9013507;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-937072;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-1295596;Reactome: R-HSA-209560;Reactome: R-HSA-6782210;Reactome: R-HSA-5689896;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-5678895;Reactome: R-HSA-936440;Reactome: R-HSA-6804760;Reactome: R-HSA-5676590;Reactome: R-HSA-192823;Reactome: R-HSA-5693565;Reactome: R-HSA-5654733;Reactome: R-HSA-209543;Reactome: R-HSA-9604323;Reactome: R-HSA-912631;Reactome: R-HSA-5205685;Reactome: R-HSA-9615710;Reactome: R-HSA-9014325;Reactome: R-HSA-5675482;Reactome: R-HSA-5696400;Reactome: R-HSA-8948751;Reactome: R-HSA-5357905;Reactome: R-HSA-5693607	"IRAK1 recruits IKK complex";"TICAM1-dependent activation of IRF3/IRF7";"Downregulation of ERBB4 signaling";"Interleukin-1 signaling";"Formation of the ternary complex, and subsequently, the 43S complex";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Circadian Clock";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"DNA Damage Recognition in GG-NER";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Degradation of beta-catenin by the destruction complex";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Alpha-protein kinase 1 signaling pathway";"Translesion synthesis by POLI";"Recognition of DNA damage by PCNA-containing replication complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"HDR through Homologous Recombination (HRR)";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence";"Fanconi Anemia Pathway";"Membrane binding and targetting of GAG proteins";"Downstream TCR signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Deactivation of the beta-catenin transactivating complex";"CLEC7A (Dectin-1) signaling";"Termination of translesion DNA synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Neddylation";"UCH proteinases";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Downregulation of TGF-beta receptor signaling";"InlA-mediated entry of Listeria monocytogenes into host cells";"Major pathway of rRNA processing in the nucleolus and cytosol";"Vif-mediated degradation of APOBEC3G";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of TP53 Degradation";"NRIF signals cell death from the nucleus";"Regulation of TP53 Activity through Phosphorylation";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Negative regulation of MET activity";"Downregulation of ERBB2:ERBB3 signaling";"MAPK6/MAPK4 signaling";"EGFR downregulation";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Regulation of PTEN localization";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Asymmetric localization of PCP proteins";"InlB-mediated entry of Listeria monocytogenes into host cell";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"Regulation of RUNX3 expression and activity";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Negative regulation of FGFR1 signaling";"Budding and maturation of HIV virion";"Negative regulation of FGFR2 signaling";"Formation of TC-NER Pre-Incision Complex";"APC/C:Cdc20 mediated degradation of Securin";"Metalloprotease DUBs";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Stabilization of p53";"Peroxisomal protein import";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Josephin domain DUBs";"ER-Phagosome pathway";"Regulation of RAS by GAPs";"Regulation of FZD by ubiquitination";"Negative regulation of FGFR3 signaling";"Regulation of PLK1 Activity at G2/M Transition";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Prevention of phagosomal-lysosomal fusion";"Chaperone Mediated Autophagy";"Activated NOTCH1 Transmits Signal to the Nucleus";"Amyloid fiber formation";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"Peptide chain elongation";"Autodegradation of Cdh1 by Cdh1:APC/C";"GLI3 is processed to GLI3R by the proteasome";"Glycogen synthesis";"activated TAK1 mediates p38 MAPK activation";"Degradation of DVL";"Assembly Of The HIV Virion";"Modulation by Mtb of host immune system";"Degradation of GLI1 by the proteasome";"APC-Cdc20 mediated degradation of Nek2A";"Formation of a pool of free 40S subunits";"Regulation of innate immune responses to cytosolic DNA";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Translesion Synthesis by POLH";"Aggrephagy";"SRP-dependent cotranslational protein targeting to membrane";"IKK complex recruitment mediated by RIP1";"Degradation of GLI2 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"E3 ubiquitin ligases ubiquitinate target proteins";"ISG15 antiviral mechanism";"Clathrin-mediated endocytosis";"CDT1 association with the CDC6:ORC:origin complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Iron uptake and transport";"TICAM1, RIP1-mediated IKK complex recruitment";"Myoclonic epilepsy of Lafora";"Cargo recognition for clathrin-mediated endocytosis";"TNFR2 non-canonical NF-kB pathway";"Senescence-Associated Secretory Phenotype (SASP)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"IRAK2 mediated activation of TAK1 complex";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Stimuli-sensing channels";"ER Quality Control Compartment (ERQC)";"NOD1/2 Signaling Pathway";"Cyclin D associated events in G1";"FCERI mediated NF-kB activation";"NOTCH1 Intracellular Domain Regulates Transcription";"Autodegradation of the E3 ubiquitin ligase COP1";"APC/C:Cdc20 mediated degradation of Cyclin B";"Downregulation of ERBB2 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Translesion synthesis by REV1";"Orc1 removal from chromatin";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"Hedgehog ligand biogenesis";"Degradation of AXIN";"ABC-family proteins mediated transport";"Formation of Incision Complex in GG-NER";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Vpu mediated degradation of CD4";"Translesion synthesis by POLK";"Regulation of RUNX2 expression and activity";"Negative regulation of MAPK pathway";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Dual incision in TC-NER";"TNFR1-induced NFkappaB signaling pathway";"Activation of NF-kappaB in B cells";"G2/M Checkpoints";"Translation initiation complex formation";"Oncogene Induced Senescence";"TCF dependent signaling in response to WNT";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Spry regulation of FGF signaling";"NF-kB is activated and signals survival";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Ovarian tumor domain proteases";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Defective CFTR causes cystic fibrosis";"Negative regulators of DDX58/IFIH1 signaling";"Regulation of TP53 Activity through Methylation";"NIK-->noncanonical NF-kB signaling";"Viral mRNA Translation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Negative regulation of FGFR4 signaling";"p75NTR recruits signalling complexes";"Negative regulation of NOTCH4 signaling";"Regulation of signaling by CBL";"Pink/Parkin Mediated Mitophagy";"Late endosomal microautophagy";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Regulation of necroptotic cell death";"Dual Incision in GG-NER";"Regulation of PTEN stability and activity";"Regulation of TNFR1 signaling";"Processing of DNA double-strand break ends"
XP_053949914.1	19	Reactome: R-HSA-8876725;Reactome: R-HSA-6790901;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-3214858;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706	"Protein methylation";"rRNA modification in the nucleus and cytosol";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"RMTs methylate histone arginines";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_053961759.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_053962833.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053962714.1	23	Reactome: R-HSA-400042;Reactome: R-HSA-432040;Reactome: R-HSA-420092;Reactome: R-HSA-500657;Reactome: R-HSA-428930;Reactome: R-HSA-8964616;Reactome: R-HSA-418594;Reactome: R-HSA-456926;Reactome: R-HSA-8964315;Reactome: R-HSA-9009391;Reactome: R-HSA-6814122;Reactome: R-HSA-416482;Reactome: R-HSA-392851;Reactome: R-HSA-381676;Reactome: R-HSA-392170;Reactome: R-HSA-418592;Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-392451;Reactome: R-HSA-418217;Reactome: R-HSA-202040;Reactome: R-HSA-418555;Reactome: R-HSA-4086398	"Adrenaline,noradrenaline inhibits insulin secretion";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon-type ligand receptors";"Presynaptic function of Kainate receptors";"Thromboxane signalling through TP receptor";"G beta:gamma signalling through CDC42";"G alpha (i) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through BTK";"Extra-nuclear estrogen signaling";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (12/13) signalling events";"Prostacyclin signalling through prostacyclin receptor";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 12";"ADP signalling through P2Y purinoceptor 1";"G alpha (z) signalling events";"G alpha (q) signalling events";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through PLC beta";"G-protein activation";"G alpha (s) signalling events";"Ca2+ pathway"
XP_053951586.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053966758.1	6	Reactome: R-HSA-418592;Reactome: R-HSA-434316;Reactome: R-HSA-416476;Reactome: R-HSA-399997;Reactome: R-HSA-456926;Reactome: R-HSA-428930	"ADP signalling through P2Y purinoceptor 1";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G alpha (q) signalling events";"Acetylcholine regulates insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor"
XP_053959831.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053950239.1	26	Reactome: R-HSA-2122947;Reactome: R-HSA-9617629;Reactome: R-HSA-3371568;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-381340;Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-9018519;Reactome: R-HSA-9614657;Reactome: R-HSA-1989781;Reactome: R-HSA-8866907;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-918233;Reactome: R-HSA-933541;Reactome: R-HSA-1368082;Reactome: R-HSA-9013508;Reactome: R-HSA-1234158;Reactome: R-HSA-5621575;Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-3899300;Reactome: R-HSA-3134973;Reactome: R-HSA-400253	"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"Attenuation phase";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Estrogen-dependent gene expression";"FOXO-mediated transcription of cell death genes";"PPARA activates gene expression";"Activation of the TFAP2 (AP-2) family of transcription factors";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF3-dependent IRF activation pathway";"TRAF6 mediated IRF7 activation";"RORA activates gene expression";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of gene expression by Hypoxia-inducible Factor";"CD209 (DC-SIGN) signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"SUMOylation of transcription cofactors";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Circadian Clock"
XP_053963693.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053950232.1	26	Reactome: R-HSA-8866907;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-918233;Reactome: R-HSA-933541;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-9614657;Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-9617629;Reactome: R-HSA-3371568;Reactome: R-HSA-3134973;Reactome: R-HSA-400253;Reactome: R-HSA-3899300;Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-5621575;Reactome: R-HSA-9013508;Reactome: R-HSA-1368082;Reactome: R-HSA-1234158	"Activation of the TFAP2 (AP-2) family of transcription factors";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"TRAF3-dependent IRF activation pathway";"TRAF6 mediated IRF7 activation";"PPARA activates gene expression";"Estrogen-dependent gene expression";"FOXO-mediated transcription of cell death genes";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"Attenuation phase";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Circadian Clock";"SUMOylation of transcription cofactors";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"CD209 (DC-SIGN) signaling";"NOTCH3 Intracellular Domain Regulates Transcription";"RORA activates gene expression";"Regulation of gene expression by Hypoxia-inducible Factor"
XP_053956421.1	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
XP_053959033.1	3	Reactome: R-HSA-2024096;Reactome: R-HSA-2206282;KEGG: 00531+3.2.1.50	"HS-GAG degradation";"MPS IIIB - Sanfilippo syndrome B";"Glycosaminoglycan degradation"
XP_053965838.1	6	Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-6798695;Reactome: R-HSA-983712	"Amino acids regulate mTORC1";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Neutrophil degranulation";"Ion channel transport"
XP_053964141.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053949600.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053948556.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053953854.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053962062.1	14	MetaCyc: PWY-5690;KEGG: 00720+1.3.5.1;Reactome: R-HSA-611105;MetaCyc: PWY-6969;MetaCyc: PWY-3781;KEGG: 00650+1.3.5.1;MetaCyc: PWY-561;MetaCyc: PWY-4302;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-7279;KEGG: 00020+1.3.5.1;MetaCyc: PWY-7254;KEGG: 00190+1.3.5.1	"TCA cycle II (plants and fungi)";"Carbon fixation pathways in prokaryotes";"Respiratory electron transport";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Aerobic respiration I (cytochrome c)";"Butanoate metabolism";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration III (alternative oxidase pathway)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Aerobic respiration II (cytochrome c) (yeast)";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Oxidative phosphorylation"
XP_053949954.1	2	Reactome: R-HSA-1483148;Reactome: R-HSA-1483166	"Synthesis of PG";"Synthesis of PA"
XP_053962069.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_053945591.1	8	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Signaling by Hippo";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway"
XP_053967733.1	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
XP_053951591.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053946417.1	15	Reactome: R-HSA-5358752;Reactome: R-HSA-196299;Reactome: R-HSA-3769402;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348;Reactome: R-HSA-5467333;Reactome: R-HSA-5358751;Reactome: R-HSA-5339716;Reactome: R-HSA-5467340;Reactome: R-HSA-5358749;Reactome: R-HSA-111465;Reactome: R-HSA-195253;Reactome: R-HSA-5358747;Reactome: R-HSA-5689896	"T41 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"Deactivation of the beta-catenin transactivating complex";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants are not K63 polyubiquitinated";"S45 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex";"S37 mutants of beta-catenin aren't phosphorylated";"Apoptotic cleavage of cellular proteins";"Degradation of beta-catenin by the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"Ovarian tumor domain proteases"
XP_053964964.1	5	Reactome: R-HSA-350054;Reactome: R-HSA-1912399;Reactome: R-HSA-1912420;Reactome: R-HSA-5083630;Reactome: R-HSA-1912408	"Notch-HLH transcription pathway";"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Pre-NOTCH Processing in Golgi";"Defective LFNG causes SCDO3";"Pre-NOTCH Transcription and Translation"
XP_053950050.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862	"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053964500.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394	"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"DNA Damage Recognition in GG-NER"
XP_053957268.1	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
XP_053952713.1	5	Reactome: R-HSA-1362409;Reactome: R-HSA-211976;Reactome: R-HSA-196108;Reactome: R-HSA-5579026;Reactome: R-HSA-2395516	"Mitochondrial iron-sulfur cluster biogenesis";"Endogenous sterols";"Pregnenolone biosynthesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Electron transport from NADPH to Ferredoxin"
XP_053963673.1	4	Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
XP_053957557.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053958000.1	3	Reactome: R-HSA-983168;Reactome: R-HSA-390471;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Association of TriC/CCT with target proteins during biosynthesis";"Neddylation"
XP_053963260.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-6796648	"Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes"
XP_053967755.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053957853.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053969711.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053955710.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053961646.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053947027.1	6	Reactome: R-HSA-6803204;Reactome: R-HSA-6803211;Reactome: R-HSA-6803207;Reactome: R-HSA-139915;Reactome: R-HSA-6803205;Reactome: R-HSA-6804759	"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"TP53 Regulates Transcription of Death Receptors and Ligands";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Activation of PUMA and translocation to mitochondria";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"Regulation of TP53 Activity through Association with Co-factors"
XP_053960522.1	42	Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5334118;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-5250924;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-73728;Reactome: R-HSA-3214815;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-212300;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-9018519;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-2299718;Reactome: R-HSA-3214842;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-427413;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"Packaging Of Telomere Ends";"Meiotic synapsis";"DNA methylation";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"B-WICH complex positively regulates rRNA expression";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Opening";"HDACs deacetylate histones";"Meiotic recombination";"Oxidative Stress Induced Senescence";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PRC2 methylates histones and DNA";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Estrogen-dependent gene expression";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Condensation of Prophase Chromosomes";"HDMs demethylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"NoRC negatively regulates rRNA expression";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_053959599.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053960529.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-5389840;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-5419276;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-5368286;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Mitochondrial translation elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Mitochondrial translation termination";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Mitochondrial translation initiation";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053967766.1	4	Reactome: R-HSA-8875656;Reactome: R-HSA-912631;Reactome: R-HSA-8875555;Reactome: R-HSA-186763	"MET receptor recycling";"Regulation of signaling by CBL";"MET activates RAP1 and RAC1";"Downstream signal transduction"
XP_053945747.1	5	Reactome: R-HSA-204005;Reactome: R-HSA-1655829;Reactome: R-HSA-5694530;Reactome: R-HSA-983170;Reactome: R-HSA-2132295	"COPII-mediated vesicle transport";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"MHC class II antigen presentation"
XP_053959347.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053954810.1	7	Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912	"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane"
XP_053961545.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053957667.1	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
XP_053957682.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053945188.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_053967363.1	3	Reactome: R-HSA-9603798;Reactome: R-HSA-8866654;Reactome: R-HSA-9033241	"Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import"
XP_053959066.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_053946064.1	2	Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2	"Signaling by SCF-KIT";"T cell receptor signaling pathway"
XP_053945832.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-1632852	"Ub-specific processing proteases";"Macroautophagy"
XP_053957968.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_053969751.1	2	Reactome: R-HSA-1237112;KEGG: 00270+3.1.3.77	"Methionine salvage pathway";"Cysteine and methionine metabolism"
XP_053962443.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_053962409.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053965440.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053958147.1	10	MetaCyc: PWY-6901;MetaCyc: PWY-8004;KEGG: 00010+2.7.2.3;MetaCyc: PWY-1042;Reactome: R-HSA-70263;MetaCyc: PWY-6886;MetaCyc: PWY-5484;KEGG: 00710+2.7.2.3;MetaCyc: PWY-7003;Reactome: R-HSA-70171	"Superpathway of glucose and xylose degradation";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Gluconeogenesis";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Carbon fixation in photosynthetic organisms";"Glycerol degradation to butanol";"Glycolysis"
XP_053952753.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053945077.1	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
XP_053947101.1	5	KEGG: 00330+1.2.1.88;Reactome: R-HSA-70688;Reactome: R-HSA-389661;KEGG: 00250+1.2.1.88;MetaCyc: PWY-6853	"Arginine and proline metabolism";"Proline catabolism";"Glyoxylate metabolism and glycine degradation";"Alanine, aspartate and glutamate metabolism";"Ethylene biosynthesis II (microbes)"
XP_053957517.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053963689.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053963667.1	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
XP_053953755.1	3	MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783	"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
XP_053952227.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_053948305.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_053946712.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053963268.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053970022.1	6	Reactome: R-HSA-68962;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-68949	"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin"
XP_053963557.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053946719.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053952356.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053965956.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_053958822.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053947521.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053953766.1	3	Reactome: R-HSA-8866654;Reactome: R-HSA-9033241;Reactome: R-HSA-9603798	"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import";"Class I peroxisomal membrane protein import"
XP_053952365.1	3	Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis"
XP_053961417.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_053945861.1	4	Reactome: R-HSA-71240;Reactome: R-HSA-352230;Reactome: R-HSA-210991;Reactome: R-HSA-5660862	"Tryptophan catabolism";"Amino acid transport across the plasma membrane";"Basigin interactions";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)"
XP_053965216.1	16	Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902	"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation"
XP_053949430.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053946009.1	16	Reactome: R-HSA-5140745;Reactome: R-HSA-8866427;Reactome: R-HSA-8964038;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-196025;Reactome: R-HSA-5099900;Reactome: R-HSA-182218;Reactome: R-HSA-2132295;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-177504;Reactome: R-HSA-164939;Reactome: R-HSA-437239;Reactome: R-HSA-167590;Reactome: R-HSA-190873	"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"VLDLR internalisation and degradation";"LDL clearance";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"Formation of annular gap junctions";"WNT5A-dependent internalization of FZD4";"Nef Mediated CD8 Down-regulation";"MHC class II antigen presentation";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Retrograde neurotrophin signalling";"Nef mediated downregulation of CD28 cell surface expression";"Recycling pathway of L1";"Nef Mediated CD4 Down-regulation";"Gap junction degradation"
XP_053952779.1	1	Reactome: R-HSA-532668	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
XP_053963619.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053951110.1	2	KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600	"Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
XP_053947249.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053955829.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053969664.1	13	Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2206308;Reactome: R-HSA-2022857;Reactome: R-HSA-4341670;MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23	"HS-GAG degradation";"Neutrophil degranulation";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid metabolism";"Sialic acid metabolism";"Galactose metabolism";"Other glycan degradation";"MPS IV - Morquio syndrome B";"Keratan sulfate degradation";"Defective NEU1 causes sialidosis";"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism"
XP_053957569.1	19	KEGG: 00630+1.1.1.37;MetaCyc: PWY-5392;MetaCyc: PWY-6969;KEGG: 00680+1.1.1.37;MetaCyc: PWY-1622;KEGG: 00720+1.1.1.37;MetaCyc: PWY-5690;MetaCyc: PWY-7383;KEGG: 00020+1.1.1.37;MetaCyc: PWY-7115;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-5913;KEGG: 00270+1.1.1.37;KEGG: 00710+1.1.1.37;KEGG: 00620+1.1.1.37;MetaCyc: PWY-8086;Reactome: R-HSA-70263;MetaCyc: PWY-561	"Glyoxylate and dicarboxylate metabolism";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methane metabolism";"Formaldehyde assimilation I (serine pathway)";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Citrate cycle (TCA cycle)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Cysteine and methionine metabolism";"Carbon fixation in photosynthetic organisms";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis";"Superpathway of glyoxylate cycle and fatty acid degradation"
XP_053946828.1	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-9633012;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Human papillomavirus infection"
XP_053954888.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_053961431.1	6	MetaCyc: PWY-5941;Reactome: R-HSA-70221;KEGG: 00500+2.4.1.1;MetaCyc: PWY-6737;MetaCyc: PWY-6731;MetaCyc: PWY-7238	"Glycogen degradation II";"Glycogen breakdown (glycogenolysis)";"Starch and sucrose metabolism";"Starch degradation V";"Starch degradation III";"Sucrose biosynthesis II"
XP_053957883.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_053965286.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_053956159.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053969554.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_053948077.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053952436.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053961462.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053967005.1	1	Reactome: R-HSA-8953750	"Transcriptional Regulation by E2F6"
XP_053958750.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_053961469.1	3	KEGG: 00310+1.14.11.8;MetaCyc: PWY-6100;Reactome: R-HSA-71262	"Lysine degradation";"L-carnitine biosynthesis";"Carnitine synthesis"
XP_053957659.1	14	Reactome: R-HSA-165054;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-69273;Reactome: R-HSA-3769402;Reactome: R-HSA-9634638;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-168333;Reactome: R-HSA-5663220;Reactome: R-HSA-450520;Reactome: R-HSA-2173788;Reactome: R-HSA-5687128	"Rev-mediated nuclear export of HIV RNA";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Cyclin A/B1/B2 associated events during G2/M transition";"Deactivation of the beta-catenin transactivating complex";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"NEP/NS2 Interacts with the Cellular Export Machinery";"RHO GTPases Activate Formins";"HuR (ELAVL1) binds and stabilizes mRNA";"Downregulation of TGF-beta receptor signaling";"MAPK6/MAPK4 signaling"
XP_053945158.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053951895.1	4	KEGG: 00030+1.1.1.49;KEGG: 00480+1.1.1.49;MetaCyc: PWY-8004;MetaCyc: PWY-7268	"Pentose phosphate pathway";"Glutathione metabolism";"Entner-Doudoroff pathway I";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
XP_053960920.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053957531.1	9	MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052;Reactome: R-HSA-1855204;MetaCyc: PWY-6351;Reactome: R-HSA-112043;MetaCyc: PWY-6367;Reactome: R-HSA-416476	"Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"PLC beta mediated events";"D-myo-inositol-5-phosphate metabolism";"G alpha (q) signalling events"
XP_053945895.1	1	KEGG: 00860+4.4.1.17	"Porphyrin and chlorophyll metabolism"
XP_053950197.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053959697.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053961806.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_053952391.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053951044.1	3	MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167	"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol"
XP_053946782.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053954722.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053969393.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053960941.1	6	KEGG: 00780+6.3.4.15;Reactome: R-HSA-196780;MetaCyc: PWY-7382;MetaCyc: PWY-6987;Reactome: R-HSA-3371599;KEGG: 00785+2.3.1.181	"Biotin metabolism";"Biotin transport and metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoate biosynthesis and incorporation III (Bacillus)";"Defective HLCS causes multiple carboxylase deficiency";"Lipoic acid metabolism"
XP_053966468.1	7	Reactome: R-HSA-3000171;Reactome: R-HSA-5083628;Reactome: R-HSA-5083629;Reactome: R-HSA-3000178;Reactome: R-HSA-9010553;Reactome: R-HSA-5083633;Reactome: R-HSA-5173105	"Non-integrin membrane-ECM interactions";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"ECM proteoglycans";"Regulation of expression of SLITs and ROBOs";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"O-linked glycosylation"
XP_053957096.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053960928.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257	"RHO GTPases Activate Formins";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion"
XP_053946376.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_053957872.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053948571.1	4	Reactome: R-HSA-216083;Reactome: R-HSA-3000170;Reactome: R-HSA-2129379;Reactome: R-HSA-3000178	"Integrin cell surface interactions";"Syndecan interactions";"Molecules associated with elastic fibres";"ECM proteoglycans"
XP_053958758.1	12	Reactome: R-HSA-76061;Reactome: R-HSA-73863;Reactome: R-HSA-1834949;Reactome: R-HSA-76066;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-76071;Reactome: R-HSA-5250924;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-73772	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase I Transcription Termination";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"RNA Polymerase I Promoter Escape"
XP_053957879.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_053945774.1	2	KEGG: 00770+6.3.2.5;Reactome: R-HSA-196783	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
XP_053957037.1	2	Reactome: R-HSA-6803157;Reactome: R-HSA-6798695	"Antimicrobial peptides";"Neutrophil degranulation"
XP_053955780.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053947942.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053954161.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053957619.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053965986.1	4	Reactome: R-HSA-211976;Reactome: R-HSA-196108;Reactome: R-HSA-2395516;Reactome: R-HSA-5579026	"Endogenous sterols";"Pregnenolone biosynthesis";"Electron transport from NADPH to Ferredoxin";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"
XP_053953344.1	7	Reactome: R-HSA-73780;Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053954139.1	5	Reactome: R-HSA-5205685;Reactome: R-HSA-5689877;Reactome: R-HSA-977225;Reactome: R-HSA-983168;Reactome: R-HSA-9646399	"Pink/Parkin Mediated Mitophagy";"Josephin domain DUBs";"Amyloid fiber formation";"Antigen processing: Ubiquitination & Proteasome degradation";"Aggrephagy"
XP_053969514.1	10	Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-163680;Reactome: R-HSA-9613354;Reactome: R-HSA-2151209;Reactome: R-HSA-6804756;Reactome: R-HSA-200425;Reactome: R-HSA-9619483;Reactome: R-HSA-380972;Reactome: R-HSA-1445148	"TP53 Regulates Metabolic Genes";"Macroautophagy";"AMPK inhibits chREBP transcriptional activation activity";"Lipophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Regulation of TP53 Activity through Phosphorylation";"Carnitine metabolism";"Activation of AMPK downstream of NMDARs";"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053969737.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-159231;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway"
XP_053957612.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_053952042.1	5	Reactome: R-HSA-8849471;Reactome: R-HSA-5658442;Reactome: R-HSA-3928662;Reactome: R-HSA-186763;Reactome: R-HSA-5218921	"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases";"Regulation of RAS by GAPs";"EPHB-mediated forward signaling";"Downstream signal transduction";"VEGFR2 mediated cell proliferation"
XP_053962464.1	6	KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_053954880.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053950275.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053952386.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053960241.1	3	Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Estrogen-dependent gene expression";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053951118.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053956971.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053953099.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053952394.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053958919.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_053954241.1	4	MetaCyc: PWY-6987;Reactome: R-HSA-389661;MetaCyc: PWY-7382;KEGG: 00785+2.8.1.8	"Lipoate biosynthesis and incorporation III (Bacillus)";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism"
XP_053958912.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_053948485.1	16	Reactome: R-HSA-174184;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-174084;Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-176407;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-2467813;Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-69017;Reactome: R-HSA-176409	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Separation of Sister Chromatids";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins"
XP_053960944.1	29	Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-5696395;Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-112382;Reactome: R-HSA-5696400;Reactome: R-HSA-167161;Reactome: R-HSA-73772;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-427413;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-167162;Reactome: R-HSA-73762;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-77075;Reactome: R-HSA-73776;Reactome: R-HSA-73863;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-6781823	"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"Formation of Incision Complex in GG-NER";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Dual Incision in GG-NER";"HIV Transcription Initiation";"RNA Polymerase I Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"NoRC negatively regulates rRNA expression";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Termination";"mRNA Capping";"Formation of the Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex"
XP_053951041.1	8	Reactome: R-HSA-5620912;Reactome: R-HSA-5689880;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"Ub-specific processing proteases";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes"
XP_053969551.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_053960139.1	6	Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-5620922;Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389957	"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"BBSome-mediated cargo-targeting to cilium";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053963704.1	17	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-6790901	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"rRNA modification in the nucleus and cytosol"
XP_053959477.1	3	MetaCyc: PWY-5129;Reactome: R-HSA-1660661;KEGG: 00600+1.14.19.17	"Sphingolipid biosynthesis (plants)";"Sphingolipid de novo biosynthesis";"Sphingolipid metabolism"
XP_053956390.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053947721.1	3	KEGG: 00250+3.5.1.1;Reactome: R-HSA-8964208;KEGG: 00460+3.5.1.1	"Alanine, aspartate and glutamate metabolism";"Phenylalanine metabolism";"Cyanoamino acid metabolism"
XP_053955660.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053962389.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_053963084.1	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
XP_053955989.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053947078.1	1	Reactome: R-HSA-446210	"Synthesis of UDP-N-acetyl-glucosamine"
XP_053948649.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72649;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053949135.1	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
XP_053957923.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053970167.1	5	Reactome: R-HSA-432722;Reactome: R-HSA-6798695;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6811440	"Golgi Associated Vesicle Biogenesis";"Neutrophil degranulation";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network"
XP_053970182.1	2	Reactome: R-HSA-399719;Reactome: R-HSA-190873	"Trafficking of AMPA receptors";"Gap junction degradation"
XP_053955982.1	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
XP_053963757.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053969017.1	16	Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-2559585;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723	"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oncogene Induced Senescence";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation"
XP_053954928.1	1	Reactome: R-HSA-112308	"Presynaptic depolarization and calcium channel opening"
XP_053952278.1	4	KEGG: 00640+1.2.1.27;MetaCyc: PWY-5642;KEGG: 00280+1.2.1.27;Reactome: R-HSA-70895	"Propanoate metabolism";"2,4-dinitrotoluene degradation";"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism"
XP_053958219.1	2	Reactome: R-HSA-5663220;Reactome: R-HSA-376176	"RHO GTPases Activate Formins";"Signaling by ROBO receptors"
XP_053962461.1	13	MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7182;MetaCyc: PWY-7709;MetaCyc: PWY-5123;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-7721;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-6859	"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Linalool biosynthesis I";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Methyl phomopsenoate biosynthesis";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"All-trans-farnesol biosynthesis"
XP_053956974.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053955668.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053960729.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053958212.1	2	Reactome: R-HSA-5663220;Reactome: R-HSA-376176	"RHO GTPases Activate Formins";"Signaling by ROBO receptors"
XP_053946980.1	4	Reactome: R-HSA-210991;Reactome: R-HSA-71240;Reactome: R-HSA-352230;Reactome: R-HSA-5660862	"Basigin interactions";"Tryptophan catabolism";"Amino acid transport across the plasma membrane";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)"
XP_053959846.1	4	Reactome: R-HSA-419037;Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053952513.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053946844.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7619;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433	"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)"
XP_053957757.1	2	Reactome: R-HSA-4086398;Reactome: R-HSA-418457	"Ca2+ pathway";"cGMP effects"
XP_053965294.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_053953616.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053969511.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053956029.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053970173.1	8	MetaCyc: PWY-922;Reactome: R-HSA-1989781;MetaCyc: PWY-6174;MetaCyc: PWY-7391;MetaCyc: PWY-7524;Reactome: R-HSA-2426168;KEGG: 00900+1.1.1.34;Reactome: R-HSA-191273	"Mevalonate pathway I";"PPARA activates gene expression";"Mevalonate pathway II (archaea)";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway III (archaea)";"Activation of gene expression by SREBF (SREBP)";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis"
XP_053945466.1	56	Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-174184;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-174154;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-382556;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-4608870;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-69017;Reactome: R-HSA-5610783	"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"Neddylation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"APC/C:Cdc20 mediated degradation of Securin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"ABC-family proteins mediated transport";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Asymmetric localization of PCP proteins";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome"
XP_053969784.1	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
XP_053955973.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_053954164.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053951455.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053951547.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-1268020	"Citric acid cycle (TCA cycle)";"Mitochondrial protein import"
XP_053951028.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053966293.1	2	Reactome: R-HSA-202433;Reactome: R-HSA-376176	"Generation of second messenger molecules";"Signaling by ROBO receptors"
XP_053955289.1	5	KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;MetaCyc: PWY-5084	"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"Tryptophan metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA"
XP_053965370.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053953515.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053947131.1	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
XP_053962432.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
XP_053962925.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053955282.1	13	KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;Reactome: R-HSA-1660662;KEGG: 00603+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52	"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"CS/DS degradation";"Other glycan degradation";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation"
XP_053955267.1	1	Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_053945771.1	2	KEGG: 00770+6.3.2.5;Reactome: R-HSA-196783	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
XP_053945809.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053969581.1	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
XP_053952887.1	1	Reactome: R-HSA-5617833	"Cilium Assembly"
XP_053951574.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_053952869.1	10	MetaCyc: PWY-6397;Reactome: R-HSA-5609977;Reactome: R-HSA-70370;MetaCyc: PWY-7328;KEGG: 00520+5.1.3.2;MetaCyc: PWY-6317;MetaCyc: PWY-7344;MetaCyc: PWY-6527;KEGG: 00052+5.1.3.2;MetaCyc: PWY-3821	"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Galactose catabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)";"UDP-alpha-D-galactose biosynthesis";"Stachyose degradation";"Galactose metabolism";"D-galactose detoxification"
XP_053958325.1	42	Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-2299718;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-427413;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5334118;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-9018519;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-212300	"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"NoRC negatively regulates rRNA expression";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"Packaging Of Telomere Ends";"Meiotic synapsis";"DNA methylation";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Estrogen-dependent gene expression";"Meiotic recombination";"Oxidative Stress Induced Senescence";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PRC2 methylates histones and DNA"
XP_053946910.1	14	Reactome: R-HSA-1474228;Reactome: R-HSA-9017802;Reactome: R-HSA-193692;Reactome: R-HSA-2979096;Reactome: R-HSA-3928665;Reactome: R-HSA-9013700;Reactome: R-HSA-1251985;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-977225;Reactome: R-HSA-2894862;Reactome: R-HSA-205043;Reactome: R-HSA-6798695;Reactome: R-HSA-2644606	"Degradation of the extracellular matrix";"Noncanonical activation of NOTCH3";"Regulated proteolysis of p75NTR";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"EPH-ephrin mediated repulsion of cells";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Amyloid fiber formation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NRIF signals cell death from the nucleus";"Neutrophil degranulation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_053963731.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053952644.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_053945574.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053956947.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053948392.1	6	KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7039;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_053951335.1	7	Reactome: R-HSA-6798695;KEGG: 00230+1.1.1.205;MetaCyc: PWY-7221;MetaCyc: PWY-5695;MetaCyc: PWY-6596;Reactome: R-HSA-73817;KEGG: 00983+1.1.1.205	"Neutrophil degranulation";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Inosine 5'-phosphate degradation";"Adenosine nucleotides degradation I";"Purine ribonucleoside monophosphate biosynthesis";"Drug metabolism - other enzymes"
XP_053955959.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053957121.1	14	Reactome: R-HSA-5696400;Reactome: R-HSA-110314;Reactome: R-HSA-5655862;Reactome: R-HSA-110320;Reactome: R-HSA-5656121;Reactome: R-HSA-69091;Reactome: R-HSA-6782135;Reactome: R-HSA-5651801;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-5685942;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-6782210	"Dual Incision in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLK";"Translesion Synthesis by POLH";"Translesion synthesis by POLI";"Polymerase switching";"Dual incision in TC-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_053955952.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053958510.1	8	Reactome: R-HSA-68616;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-68827;Reactome: R-HSA-68867	"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the pre-replicative complex"
XP_053959735.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053962359.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053969714.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_053963054.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053966423.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053957762.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053951649.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053951603.1	2	KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10	"Glycine, serine and threonine metabolism";"One carbon pool by folate"
XP_053957769.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053945864.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-425561	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Sodium/Calcium exchangers"
XP_053950526.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_053961307.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_053963121.1	14	Reactome: R-HSA-141444;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-68877;Reactome: R-HSA-380320;Reactome: R-HSA-9648025;Reactome: R-HSA-5620912	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"Mitotic Prometaphase";"Recruitment of NuMA to mitotic centrosomes";"EML4 and NUDC in mitotic spindle formation";"Anchoring of the basal body to the plasma membrane"
XP_053969596.1	5	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-8866654;Reactome: R-HSA-201722;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of the beta-catenin:TCF transactivating complex";"Formation of RNA Pol II elongation complex"
XP_053945642.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053952572.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053959505.1	3	KEGG: 00510+2.4.1.267;Reactome: R-HSA-4724289;Reactome: R-HSA-446193	"N-Glycan biosynthesis";"Defective ALG6 causes ALG6-CDG (CDG-1c)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
XP_053948415.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053958982.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_053954102.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_053957148.1	1	Reactome: R-HSA-977347	"Serine biosynthesis"
XP_053953474.1	2	KEGG: 00970+6.1.1.2;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
XP_053946657.1	2	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_053963140.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053969062.1	5	KEGG: 00230+2.7.4.3;KEGG: 00230+2.7.4.10;MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3	"Purine metabolism";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism"
XP_053960977.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053954529.1	2	Reactome: R-HSA-3108214;MetaCyc: PWY-7511	"SUMOylation of DNA damage response and repair proteins";"Protein ubiquitination"
XP_053946589.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053955259.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_053946863.1	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
XP_053961354.1	24	Reactome: R-HSA-8963896;Reactome: R-HSA-5610785;Reactome: R-HSA-9634600;Reactome: R-HSA-180024;Reactome: R-HSA-5621575;Reactome: R-HSA-9010642;KEGG: 04150+2.7.11.11;Reactome: R-HSA-392517;Reactome: R-HSA-163358;Reactome: R-HSA-163615;Reactome: R-HSA-111931;Reactome: R-HSA-983231;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-381676;Reactome: R-HSA-5610783;Reactome: R-HSA-163560;Reactome: R-HSA-4420097;Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-422356;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-8853659	"HDL assembly";"GLI3 is processed to GLI3R by the proteasome";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"DARPP-32 events";"CD209 (DC-SIGN) signaling";"ROBO receptors bind AKAP5";"mTOR signaling pathway";"Rap1 signalling";"PKA-mediated phosphorylation of key metabolic factors";"PKA activation";"PKA-mediated phosphorylation of CREB";"Factors involved in megakaryocyte development and platelet production";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Degradation of GLI2 by the proteasome";"Triglyceride catabolism";"VEGFA-VEGFR2 Pathway";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"Regulation of insulin secretion";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"RET signaling"
XP_053945485.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_053954522.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053959125.1	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
XP_053946258.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_053967686.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_053960195.1	7	Reactome: R-HSA-8953750;Reactome: R-HSA-3214841;Reactome: R-HSA-8943724;Reactome: R-HSA-9609690;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-212300	"Transcriptional Regulation by E2F6";"PKMTs methylate histone lysines";"Regulation of PTEN gene transcription";"HCMV Early Events";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PRC2 methylates histones and DNA"
XP_053950106.1	4	Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-375165;Reactome: R-HSA-5673001	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade"
XP_053951485.1	5	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-3928665;Reactome: R-HSA-190873;Reactome: R-HSA-196025	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"Gap junction degradation";"Formation of annular gap junctions"
XP_053969170.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053946446.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053959444.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053946213.1	2	Reactome: R-HSA-425393;Reactome: R-HSA-5223345	"Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events"
XP_053964691.1	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
XP_053957490.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053954121.1	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
XP_053946181.1	3	Reactome: R-HSA-110329;Reactome: R-HSA-110328;Reactome: R-HSA-110357	"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Displacement of DNA glycosylase by APEX1"
XP_053951600.1	1	Reactome: R-HSA-419037	"NCAM1 interactions"
XP_053960734.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053963143.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053968225.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053969838.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_053956751.1	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
XP_053951907.1	3	KEGG: 00790+2.10.1.1;MetaCyc: PWY-6823;Reactome: R-HSA-947581	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
XP_053968046.1	6	Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2467813	"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids"
XP_053948023.1	8	MetaCyc: PWY-7400;MetaCyc: PWY-4983;Reactome: R-HSA-70635;MetaCyc: PWY-5;KEGG: 00220+6.3.4.5;MetaCyc: PWY-5154;MetaCyc: PWY-4984;KEGG: 00250+6.3.4.5	"L-arginine biosynthesis IV (archaebacteria)";"Nitric oxide biosynthesis II (mammals)";"Urea cycle";"Canavanine biosynthesis";"Arginine biosynthesis";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Urea cycle";"Alanine, aspartate and glutamate metabolism"
XP_053962424.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053952919.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053945214.1	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
XP_053969173.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053966015.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053958553.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053946137.1	4	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Ion channel transport"
XP_053961235.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361;Reactome: R-HSA-5250958	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Neurexins and neuroligins";"Toxicity of botulinum toxin type B (BoNT/B)"
XP_053950377.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053954014.1	2	Reactome: R-HSA-389661;Reactome: R-HSA-6783984	"Glyoxylate metabolism and glycine degradation";"Glycine degradation"
XP_053956034.1	2	MetaCyc: PWY-5381;KEGG: 00760+2.7.1.173+2.7.1.22	"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism"
XP_053965312.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053962145.1	7	MetaCyc: PWY-8004;MetaCyc: PWY-6906;Reactome: R-HSA-71336;KEGG: 00520+3.5.99.6;KEGG: 00030+3.1.1.31;MetaCyc: PWY-6855;MetaCyc: PWY-5514	"Entner-Doudoroff pathway I";"Chitin derivatives degradation";"Pentose phosphate pathway";"Amino sugar and nucleotide sugar metabolism";"Pentose phosphate pathway";"Chitin degradation I (archaea)";"UDP-N-acetyl-D-galactosamine biosynthesis II"
XP_053966592.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053959194.1	5	Reactome: R-HSA-8856825;Reactome: R-HSA-5689603;Reactome: R-HSA-2173789;Reactome: R-HSA-917937;Reactome: R-HSA-8951664	"Cargo recognition for clathrin-mediated endocytosis";"UCH proteinases";"TGF-beta receptor signaling activates SMADs";"Iron uptake and transport";"Neddylation"
XP_053948821.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053957522.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053947764.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_053964686.1	6	Reactome: R-HSA-72163;Reactome: R-HSA-6782210;Reactome: R-HSA-6798695;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135	"mRNA Splicing - Major Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Neutrophil degranulation";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER"
XP_053960124.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053969624.1	2	Reactome: R-HSA-6787450;Reactome: R-HSA-6782315	"tRNA modification in the mitochondrion";"tRNA modification in the nucleus and cytosol"
XP_053945207.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053955406.1	1	Reactome: R-HSA-8964572	"Lipid particle organization"
XP_053960445.1	42	Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-212300;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-9018519;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5334118;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-427389;Reactome: R-HSA-5250924;Reactome: R-HSA-3214858;Reactome: R-HSA-73728;Reactome: R-HSA-3214815;Reactome: R-HSA-2299718;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-427413;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-427359;Reactome: R-HSA-5578749	"Meiotic recombination";"Oxidative Stress Induced Senescence";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PRC2 methylates histones and DNA";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Estrogen-dependent gene expression";"Packaging Of Telomere Ends";"Meiotic synapsis";"DNA methylation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"B-WICH complex positively regulates rRNA expression";"RMTs methylate histone arginines";"RNA Polymerase I Promoter Opening";"HDACs deacetylate histones";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"NoRC negatively regulates rRNA expression";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs"
XP_053954007.1	4	Reactome: R-HSA-5625970;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"RHO GTPases activate KTN1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053958677.1	6	Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257	"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion"
XP_053947052.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-426486	"MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis"
XP_053952212.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053945914.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053952952.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_053957498.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-163282	"Transcriptional activation of mitochondrial biogenesis";"Mitochondrial transcription initiation"
XP_053966066.1	6	KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I"
XP_053952219.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling"
XP_053960667.1	31	Reactome: R-HSA-9029558;MetaCyc: PWY-5971;MetaCyc: PWYG-321;MetaCyc: PWY-5142;MetaCyc: PWY-6519;MetaCyc: PWY-7858;MetaCyc: PWY-6113;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;Reactome: R-HSA-199220;MetaCyc: PWY-7663;MetaCyc: PWY-5367;MetaCyc: PWY-8049;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7723;MetaCyc: PWY-4381;Reactome: R-HSA-163765;MetaCyc: PWY-6799;MetaCyc: PWY-5966-1;Reactome: R-HSA-2426168;MetaCyc: PWY-8012;MetaCyc: PWY-6282;MetaCyc: PWY-5147;MetaCyc: PWY-8047;MetaCyc: PWY-5994;MetaCyc: PWY-7388;Reactome: R-HSA-75105;MetaCyc: PWY-7664;MetaCyc: PWY-5973;MetaCyc: PWY-5366;MetaCyc: PWY-7746;MetaCyc: PWY-5989	"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"";"Acyl-[acyl-carrier protein] thioesterase pathway";"8-amino-7-oxononanoate biosynthesis I";"(5Z)-dodecenoate biosynthesis II";"Superpathway of mycolate biosynthesis";"Fatty acid biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Gondoate biosynthesis (anaerobic)";"Petroselinate biosynthesis";"Pederin biosynthesis";"Biotin metabolism";"Bacterial bioluminescence";"Fatty acid biosynthesis initiation (bacteria and plants)";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Activation of gene expression by SREBF (SREBP)";"Mupirocin biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Oleate biosynthesis I (plants)";"Bryostatin biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acyl-CoA biosynthesis";"Oleate biosynthesis IV (anaerobic)";"Cis-vaccenate biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Mycobacterial sulfolipid biosynthesis";"Stearate biosynthesis II (bacteria and plants)"
XP_053954054.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-5205685	"Mitochondrial protein import";"Pink/Parkin Mediated Mitophagy"
XP_053965352.1	16	Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-176407;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-174184;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-174084;Reactome: R-HSA-174048;Reactome: R-HSA-176408;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-2467813;Reactome: R-HSA-141430;Reactome: R-HSA-8853884	"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Separation of Sister Chromatids";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Transcriptional Regulation by VENTX"
XP_053968776.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053955831.1	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053966347.1	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
XP_053966055.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_053949449.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053957143.1	18	KEGG: 00250+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00950+2.6.1.1;MetaCyc: PWY-6642;MetaCyc: PWY-5913;KEGG: 00220+2.6.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-7117;KEGG: 00350+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00270+2.6.1.1;KEGG: 00710+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00400+2.6.1.1;KEGG: 00330+2.6.1.1;MetaCyc: PWY-6638;MetaCyc: PWY-7383	"Alanine, aspartate and glutamate metabolism";"Phenylalanine metabolism";"Isoquinoline alkaloid biosynthesis";"(R)-cysteate degradation";"Partial TCA cycle (obligate autotrophs)";"Arginine biosynthesis";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Tyrosine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Novobiocin biosynthesis";"Cysteine and methionine metabolism";"Carbon fixation in photosynthetic organisms";"Coenzyme M biosynthesis II";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine and proline metabolism";"Sulfolactate degradation III";"Anaerobic energy metabolism (invertebrates, cytosol)"
XP_053965461.1	5	MetaCyc: PWY-7268;MetaCyc: PWY-7269;MetaCyc: PWY-5083;Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23	"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism"
XP_053963627.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053961999.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_053962826.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053948914.1	5	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-6798695;Reactome: R-HSA-8856828;Reactome: R-HSA-3928662	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"Neutrophil degranulation";"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling"
XP_053961992.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053964616.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_053955817.1	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
XP_053946983.1	4	Reactome: R-HSA-352230;Reactome: R-HSA-71240;Reactome: R-HSA-210991;Reactome: R-HSA-5660862	"Amino acid transport across the plasma membrane";"Tryptophan catabolism";"Basigin interactions";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)"
XP_053954375.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053968352.1	4	Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193	"Pyrimidine salvage";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I"
XP_053954923.1	6	MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-7782	"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis"
XP_053952325.1	7	Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-1655829;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-203927;Reactome: R-HSA-6784531	"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"MicroRNA (miRNA) biogenesis";"tRNA processing in the nucleus"
XP_053957241.1	1	Reactome: R-HSA-71288	"Creatine metabolism"
XP_053951840.1	9	Reactome: R-HSA-9649948;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-6802946;Reactome: R-HSA-114608;Reactome: R-HSA-445355;Reactome: R-HSA-6802955;Reactome: R-HSA-6798695;Reactome: R-HSA-6802952	"Signaling downstream of RAS mutants";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Signaling by moderate kinase activity BRAF mutants";"Platelet degranulation";"Smooth Muscle Contraction";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Neutrophil degranulation";"Signaling by BRAF and RAF fusions"
XP_053958887.1	6	Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156827	"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_053953726.1	4	Reactome: R-HSA-9010553;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-975957	"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053970170.1	3	Reactome: R-HSA-174403;KEGG: 00480+4.3.2.7;MetaCyc: PWY-7942	"Glutathione synthesis and recycling";"Glutathione metabolism";"5-oxo-L-proline metabolism"
XP_053960081.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053966535.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053970062.1	7	MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-5469;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-7445;MetaCyc: PWY-6824	"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Sesamin biosynthesis";"Betanidin degradation";"Phenylpropanoid biosynthesis";"Luteolin triglucuronide degradation";"Justicidin B biosynthesis"
XP_053949516.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053956514.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053966290.1	2	Reactome: R-HSA-202433;Reactome: R-HSA-376176	"Generation of second messenger molecules";"Signaling by ROBO receptors"
XP_053964876.1	3	KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3	"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis"
XP_053954717.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053965432.1	3	Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916	"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium"
XP_053952558.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_053948214.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_053970178.1	2	Reactome: R-HSA-399719;Reactome: R-HSA-190873	"Trafficking of AMPA receptors";"Gap junction degradation"
XP_053955978.1	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
XP_053960883.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053955394.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053946972.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053951848.1	3	Reactome: R-HSA-6787450;MetaCyc: PWY-7892;MetaCyc: PWY-7887	"tRNA modification in the mitochondrion";"Trna-uridine 2-thiolation and selenation (bacteria)";"Protein SAMPylation and SAMP-mediated thiolation"
XP_053949794.1	1	KEGG: 00906+1.23.5.1	"Carotenoid biosynthesis"
XP_053968312.1	12	KEGG: 00030+4.1.2.13;KEGG: 00680+4.1.2.13;Reactome: R-HSA-70171;KEGG: 00010+4.1.2.13;MetaCyc: PWY-5484;KEGG: 00710+4.1.2.13;MetaCyc: PWY-1861;MetaCyc: PWY-1042;Reactome: R-HSA-70263;MetaCyc: PWY-7385;KEGG: 00051+4.1.2.13;MetaCyc: PWY-6142	"Pentose phosphate pathway";"Methane metabolism";"Glycolysis";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis IV (plant cytosol)";"Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)";"Fructose and mannose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
XP_053945848.1	5	Reactome: R-HSA-168638;Reactome: R-HSA-376172;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;KEGG: 04150+2.7.11.24	"NOD1/2 Signaling Pathway";"DSCAM interactions";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"mTOR signaling pathway"
XP_053962994.1	7	Reactome: R-HSA-8856828;Reactome: R-HSA-1855204;KEGG: 04070+3.1.3.36;KEGG: 00562+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1660499	"Clathrin-mediated endocytosis";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the plasma membrane"
XP_053956507.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053957228.1	3	KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348	"Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition"
XP_053954704.1	5	Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-4641257;Reactome: R-HSA-201681;MetaCyc: PWY-7511	"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"Degradation of AXIN";"TCF dependent signaling in response to WNT";"Protein ubiquitination"
XP_053954223.1	2	Reactome: R-HSA-3214847;Reactome: R-HSA-427413	"HATs acetylate histones";"NoRC negatively regulates rRNA expression"
XP_053962378.1	11	Reactome: R-HSA-6807878;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-3371497;Reactome: R-HSA-380320;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-2132295	"COPI-mediated anterograde transport";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of NuMA to mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"MHC class II antigen presentation"
XP_053965382.1	3	Reactome: R-HSA-390471;Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Association of TriC/CCT with target proteins during biosynthesis";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053957941.1	5	MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-7822	"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)"
XP_053967975.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053948907.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053954084.1	17	Reactome: R-HSA-174417;Reactome: R-HSA-69091;Reactome: R-HSA-6782135;Reactome: R-HSA-174414;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-5358606;Reactome: R-HSA-5358565;Reactome: R-HSA-69166;Reactome: R-HSA-5651801;Reactome: R-HSA-174437;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-5685942;Reactome: R-HSA-5696400;Reactome: R-HSA-69183;Reactome: R-HSA-110314	"Telomere C-strand (Lagging Strand) Synthesis";"Polymerase switching";"Dual incision in TC-NER";"Processive synthesis on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Removal of the Flap Intermediate";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate from the C-strand";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HDR through Homologous Recombination (HRR)";"Dual Incision in GG-NER";"Processive synthesis on the lagging strand";"Recognition of DNA damage by PCNA-containing replication complex"
XP_053946024.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation"
XP_053955663.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053969271.1	4	KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282;MetaCyc: PWY-7204;Reactome: R-HSA-964975	"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Pyridoxal 5'-phosphate salvage II (plants)";"Vitamins B6 activation to pyridoxal phosphate"
XP_053965389.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_053947702.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053945284.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053954757.1	8	Reactome: R-HSA-3214841;Reactome: R-HSA-2559580;Reactome: R-HSA-8943724;Reactome: R-HSA-5617472;Reactome: R-HSA-212300;Reactome: R-HSA-8953750;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690	"PKMTs methylate histone lysines";"Oxidative Stress Induced Senescence";"Regulation of PTEN gene transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PRC2 methylates histones and DNA";"Transcriptional Regulation by E2F6";"SUMOylation of chromatin organization proteins";"HCMV Early Events"
XP_053960652.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053958033.1	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
XP_053947607.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Neddylation"
XP_053945981.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053950555.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053964005.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053949006.1	56	Reactome: R-HSA-4641257;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4641258;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-9604323;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-5658442;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-69481;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-450408;Reactome: R-HSA-4608870;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-382556	"Degradation of AXIN";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of DVL";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Negative regulation of NOTCH4 signaling";"Hedgehog 'on' state";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Regulation of RAS by GAPs";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"G2/M Checkpoints";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Asymmetric localization of PCP proteins";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport"
XP_053966792.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053966463.1	7	Reactome: R-HSA-9010553;Reactome: R-HSA-5173105;Reactome: R-HSA-5083633;Reactome: R-HSA-5083629;Reactome: R-HSA-3000178;Reactome: R-HSA-5083628;Reactome: R-HSA-3000171	"Regulation of expression of SLITs and ROBOs";"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"ECM proteoglycans";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Non-integrin membrane-ECM interactions"
XP_053960084.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053950328.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053951981.1	4	KEGG: 00562+1.13.99.1;Reactome: R-HSA-1855183;KEGG: 00053+1.13.99.1;MetaCyc: PWY-4841	"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Ascorbate and aldarate metabolism";"UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)"
XP_053969398.1	4	MetaCyc: PWY-6281;KEGG: 00450+2.9.1.2;Reactome: R-HSA-2408557;KEGG: 00970+2.9.1.2	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocompound metabolism";"Selenocysteine synthesis";"Aminoacyl-tRNA biosynthesis"
XP_053951937.1	3	Reactome: R-HSA-446193;KEGG: 00510+2.4.1.256;Reactome: R-HSA-936837	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Ion transport by P-type ATPases"
XP_053969808.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_053963139.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053959156.1	25	Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-392451;Reactome: R-HSA-418217;Reactome: R-HSA-202040;Reactome: R-HSA-418555;Reactome: R-HSA-4086398;Reactome: R-HSA-8964616;Reactome: R-HSA-418594;Reactome: R-HSA-456926;Reactome: R-HSA-8964315;Reactome: R-HSA-432040;Reactome: R-HSA-400042;Reactome: R-HSA-500657;Reactome: R-HSA-420092;Reactome: R-HSA-428930;Reactome: R-HSA-163359;Reactome: R-HSA-392851;Reactome: R-HSA-6814122;Reactome: R-HSA-9009391;Reactome: R-HSA-416482;Reactome: R-HSA-418592;Reactome: R-HSA-381771;Reactome: R-HSA-381676;Reactome: R-HSA-392170	"G alpha (z) signalling events";"G alpha (q) signalling events";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through PLC beta";"G-protein activation";"G alpha (s) signalling events";"Ca2+ pathway";"G beta:gamma signalling through CDC42";"G alpha (i) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through BTK";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adrenaline,noradrenaline inhibits insulin secretion";"Presynaptic function of Kainate receptors";"Glucagon-type ligand receptors";"Thromboxane signalling through TP receptor";"Glucagon signaling in metabolic regulation";"Prostacyclin signalling through prostacyclin receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Extra-nuclear estrogen signaling";"G alpha (12/13) signalling events";"ADP signalling through P2Y purinoceptor 1";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 12"
XP_053950656.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053962291.1	3	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-6807505	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes"
XP_053963132.1	10	MetaCyc: PWY-6369;MetaCyc: PWY-6361;MetaCyc: PWY-6554;MetaCyc: PWY-6362;KEGG: 00562+2.7.1.158;KEGG: 04070+2.7.1.158;MetaCyc: PWY-4661;Reactome: R-HSA-1855191;Reactome: R-HSA-1855167;MetaCyc: PWY-6372	"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Synthesis of IPs in the nucleus";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)"
XP_053946527.1	4	Reactome: R-HSA-446193;KEGG: 00513+2.4.1.260;KEGG: 00510+2.4.1.260;Reactome: R-HSA-4720489	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective ALG12 causes ALG12-CDG (CDG-1g)"
XP_053950665.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053954587.1	8	Reactome: R-HSA-69166;Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-174411;Reactome: R-HSA-69091;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-174430	"Removal of the Flap Intermediate";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"Polymerase switching on the C-strand of the telomere";"Polymerase switching";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Telomere C-strand synthesis initiation"
XP_053947795.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053950099.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053951630.1	20	MetaCyc: PWY-7854;MetaCyc: PWY-5136;MetaCyc: PWY-7574;MetaCyc: PWY-7337;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-7288;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6920;MetaCyc: PWY-7340;MetaCyc: PWY-7726;Reactome: R-HSA-9033241;MetaCyc: PWY-7858;MetaCyc: PWY-7338;MetaCyc: PWY-7007;MetaCyc: PWY-6837;MetaCyc: PWY-7291;MetaCyc: PWY-7606;KEGG: 00640+1.3.3.6;KEGG: 00410+1.3.3.6	"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Fatty acid degradation";"6-gingerol analog biosynthesis (engineered)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Peroxisomal protein import";"(5Z)-dodecenoate biosynthesis II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Methyl ketone biosynthesis (engineered)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Propanoate metabolism";"beta-Alanine metabolism"
XP_053946823.1	4	MetaCyc: PWY-7174;Reactome: R-HSA-1237112;KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Methionine salvage pathway";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053948251.1	24	Reactome: R-HSA-418217;Reactome: R-HSA-392451;Reactome: R-HSA-4086398;Reactome: R-HSA-418555;Reactome: R-HSA-202040;Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-416482;Reactome: R-HSA-6814122;Reactome: R-HSA-9009391;Reactome: R-HSA-392851;Reactome: R-HSA-392170;Reactome: R-HSA-381676;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-420092;Reactome: R-HSA-500657;Reactome: R-HSA-432040;Reactome: R-HSA-400042;Reactome: R-HSA-8964315;Reactome: R-HSA-418594;Reactome: R-HSA-456926;Reactome: R-HSA-8964616;Reactome: R-HSA-163359	"G beta:gamma signalling through PLC beta";"G beta:gamma signalling through PI3Kgamma";"Ca2+ pathway";"G alpha (s) signalling events";"G-protein activation";"G alpha (z) signalling events";"G alpha (q) signalling events";"G alpha (12/13) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Extra-nuclear estrogen signaling";"Prostacyclin signalling through prostacyclin receptor";"ADP signalling through P2Y purinoceptor 12";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Glucagon-type ligand receptors";"Presynaptic function of Kainate receptors";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adrenaline,noradrenaline inhibits insulin secretion";"G beta:gamma signalling through BTK";"G alpha (i) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through CDC42";"Glucagon signaling in metabolic regulation"
XP_053945937.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053957132.1	3	MetaCyc: PWY-8106;Reactome: R-HSA-6782315;MetaCyc: PWY-6700	"Queuosine biosynthesis III (queuosine salvage)";"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis I (de novo)"
XP_053945281.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053958227.1	2	Reactome: R-HSA-1483115;Reactome: R-HSA-1483152	"Hydrolysis of LPC";"Hydrolysis of LPE"
XP_053950515.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_053946021.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053954081.1	5	KEGG: 00860+4.2.1.24;Reactome: R-HSA-189451;Reactome: R-HSA-6798695;MetaCyc: PWY-5188;MetaCyc: PWY-5189	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Neutrophil degranulation";"Tetrapyrrole biosynthesis I (from glutamate)";"Tetrapyrrole biosynthesis II (from glycine)"
XP_053951996.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_053957880.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053951281.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053951113.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053954872.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053958753.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053960375.1	42	Reactome: R-HSA-5334118;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-3214815;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-9018519;Reactome: R-HSA-5693607;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-110331;Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-2299718;Reactome: R-HSA-427413;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"DNA methylation";"Packaging Of Telomere Ends";"Meiotic synapsis";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"HDACs deacetylate histones";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Meiotic recombination";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Estrogen-dependent gene expression";"Processing of DNA double-strand break ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Cleavage of the damaged purine";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"Condensation of Prophase Chromosomes";"NoRC negatively regulates rRNA expression";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_053960923.1	7	Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-5626467;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-68877	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase"
XP_053962286.1	5	Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-75035;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897	"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes"
XP_053950341.1	1	Reactome: R-HSA-1855231	"Synthesis of IPs in the ER lumen"
XP_053954701.1	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
XP_053956017.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053959116.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053950616.1	3	KEGG: 00250+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00460+3.5.1.1	"Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism";"Cyanoamino acid metabolism"
XP_053946114.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053956661.1	4	Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814;Reactome: R-HSA-2022090	"Collagen chain trimerization";"Collagen degradation";"Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures"
XP_053963722.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_053969390.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
XP_053948183.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053955391.1	6	Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72649	"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation"
XP_053950320.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053947908.1	3	Reactome: R-HSA-5696394;Reactome: R-HSA-5689877;Reactome: R-HSA-5696395	"DNA Damage Recognition in GG-NER";"Josephin domain DUBs";"Formation of Incision Complex in GG-NER"
XP_053945237.1	4	Reactome: R-HSA-2214320;Reactome: R-HSA-1474228;Reactome: R-HSA-1650814;Reactome: R-HSA-2243919	"Anchoring fibril formation";"Degradation of the extracellular matrix";"Collagen biosynthesis and modifying enzymes";"Crosslinking of collagen fibrils"
XP_053963729.1	6	MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884	"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I"
XP_053952788.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053952750.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053966505.1	4	Reactome: R-HSA-3304356;Reactome: R-HSA-3656532;Reactome: R-HSA-2173788;Reactome: R-HSA-2173789	"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"Downregulation of TGF-beta receptor signaling";"TGF-beta receptor signaling activates SMADs"
XP_053951211.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053952174.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053954011.1	4	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"RHO GTPases activate KTN1"
XP_053956031.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053960493.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053945211.1	18	MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482922;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1482839;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482801;MetaCyc: PWY-8053;MetaCyc: PWY-7417;Reactome: R-HSA-1482925;Reactome: R-HSA-1482788	"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Plasmalogen degradation";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Acyl chain remodelling of PI";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Acyl chain remodelling of PE";"Synthesis of PA";"Glycerophospholipid metabolism";"Acyl chain remodelling of PS";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PG";"Acyl chain remodelling of PC"
XP_053958391.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_053962421.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_053947502.1	7	KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053951426.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053962965.1	1	Reactome: R-HSA-2142789	"Ubiquinol biosynthesis"
XP_053960731.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053954557.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053966606.1	4	MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48;KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614	"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Pyrimidine salvage"
XP_053947847.1	14	Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167242;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-674695;Reactome: R-HSA-6796648	"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes"
XP_053958772.1	2	KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20	"Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis"
XP_053947543.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053948113.1	1	KEGG: 00450+1.8.1.9	"Selenocompound metabolism"
XP_053957195.1	4	Reactome: R-HSA-111465;Reactome: R-HSA-176187;Reactome: R-HSA-5689880;Reactome: R-HSA-5693607	"Apoptotic cleavage of cellular proteins";"Activation of ATR in response to replication stress";"Ub-specific processing proteases";"Processing of DNA double-strand break ends"
XP_053962956.1	3	Reactome: R-HSA-426048;MetaCyc: PWY-7420;KEGG: 00561+3.1.1.23	"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)";"Glycerolipid metabolism"
XP_053964694.1	2	MetaCyc: PWY-7799;MetaCyc: PWY-7802	"Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)"
XP_053949765.1	56	Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-202424;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-5676590;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-9604323;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4641257;Reactome: R-HSA-382556;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-174178;Reactome: R-HSA-4608870;Reactome: R-HSA-450408;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Downstream TCR signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"NIK-->noncanonical NF-kB signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"Negative regulation of NOTCH4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of AXIN";"ABC-family proteins mediated transport";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Asymmetric localization of PCP proteins";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases"
XP_053966125.1	2	MetaCyc: PWY-6281;KEGG: 00450+2.7.9.3	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocompound metabolism"
XP_053947684.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation"
XP_053955365.1	3	KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067;Reactome: R-HSA-3322077	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen synthesis"
XP_053957850.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053963858.1	14	Reactome: R-HSA-75109;KEGG: 00564+3.1.3.4;Reactome: R-HSA-1483191;Reactome: R-HSA-4419969;MetaCyc: PWY-8052;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;KEGG: 00565+3.1.3.4;MetaCyc: PWY-8053;KEGG: 00561+3.1.3.4;Reactome: R-HSA-1483213	"Triglyceride biosynthesis";"Glycerophospholipid metabolism";"Synthesis of PC";"Depolymerisation of the Nuclear Lamina";"2-arachidonoylglycerol biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Ether lipid metabolism";"Anandamide biosynthesis II";"Glycerolipid metabolism";"Synthesis of PE"
XP_053960014.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053958042.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053952710.1	5	Reactome: R-HSA-964975;KEGG: 00750+2.7.1.35;MetaCyc: PWY-7204;MetaCyc: PWY-7282;Reactome: R-HSA-6798695	"Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism";"Pyridoxal 5'-phosphate salvage II (plants)";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Neutrophil degranulation"
XP_053958003.1	3	Reactome: R-HSA-390471;Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Association of TriC/CCT with target proteins during biosynthesis";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053956581.1	12	MetaCyc: PWY-7783;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-8053	"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II"
XP_053968464.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053951172.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053963810.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_053964715.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053966735.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053948296.1	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
XP_053962265.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_053957818.1	1	Reactome: R-HSA-446203	"Asparagine N-linked glycosylation"
XP_053960140.1	7	Reactome: R-HSA-5362517;KEGG: 00620+2.3.1.12;Reactome: R-HSA-389661;Reactome: R-HSA-204174;Reactome: R-HSA-70268;KEGG: 00020+2.3.1.12;KEGG: 00010+2.3.1.12	"Signaling by Retinoic Acid";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Glycolysis / Gluconeogenesis"
XP_053965675.1	3	Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300	"SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors"
XP_053950474.1	20	Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-5685942;Reactome: R-HSA-110312;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-5651801;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-69091;Reactome: R-HSA-6782135;Reactome: R-HSA-5656121;Reactome: R-HSA-110320;Reactome: R-HSA-6804756;Reactome: R-HSA-176187;Reactome: R-HSA-5655862;Reactome: R-HSA-5685938;Reactome: R-HSA-110314;Reactome: R-HSA-5693607;Reactome: R-HSA-5696400	"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by REV1";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"Polymerase switching";"Dual incision in TC-NER";"Translesion synthesis by POLI";"Translesion Synthesis by POLH";"Regulation of TP53 Activity through Phosphorylation";"Activation of ATR in response to replication stress";"Translesion synthesis by POLK";"HDR through Single Strand Annealing (SSA)";"Recognition of DNA damage by PCNA-containing replication complex";"Processing of DNA double-strand break ends";"Dual Incision in GG-NER"
XP_053954517.1	56	Reactome: R-HSA-5689880;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-69481;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-450408;Reactome: R-HSA-180534;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-4608870;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-5358346;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4641257;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-9604323;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236	"Ub-specific processing proteases";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"G2/M Checkpoints";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vpu mediated degradation of CD4";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Asymmetric localization of PCP proteins";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"Hedgehog ligand biogenesis";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of AXIN";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"Negative regulation of NOTCH4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Downstream TCR signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
XP_053956537.1	5	KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-3821;MetaCyc: PWY-6317;KEGG: 00520+2.7.1.6	"Galactose metabolism";"Stachyose degradation";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism"
XP_053952758.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053962256.1	24	Reactome: R-HSA-380320;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-190861;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2132295;Reactome: R-HSA-8955332;Reactome: R-HSA-9648025;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-983189;Reactome: R-HSA-190840	"Recruitment of NuMA to mitotic centrosomes";"Cilium Assembly";"Aggrephagy";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Gap junction assembly";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"RHO GTPases activate IQGAPs";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"MHC class II antigen presentation";"Carboxyterminal post-translational modifications of tubulin";"EML4 and NUDC in mitotic spindle formation";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Kinesins";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"
XP_053948824.1	4	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"DARPP-32 events";"Th1 and Th2 cell differentiation"
XP_053956198.1	14	MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7036;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7619;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7725	"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation";"Sciadonate biosynthesis";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)"
XP_053964397.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053963690.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053957936.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053956866.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053950811.1	2	Reactome: R-HSA-1299308;Reactome: R-HSA-5576886	"Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)";"Phase 4 - resting membrane potential"
XP_053962838.1	3	Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs"
XP_053968017.1	2	Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
XP_053951199.1	18	Reactome: R-HSA-1482801;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482839;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925;MetaCyc: PWY-7417;MetaCyc: PWY-8053;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-6803;Reactome: R-HSA-1482922	"Acyl chain remodelling of PS";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PE";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PI"
XP_053949642.1	11	Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-163359;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555	"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"G alpha (i) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"G alpha (s) signalling events"
XP_053959912.1	42	Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-9018519;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5334118;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-2299718;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-427413;Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-1912408;Reactome: R-HSA-110331	"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Estrogen-dependent gene expression";"Meiotic recombination";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"Packaging Of Telomere Ends";"Meiotic synapsis";"DNA methylation";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"NoRC negatively regulates rRNA expression";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine"
XP_053947496.1	10	KEGG: 05163+2.7.1.153;MetaCyc: PWY-6352;KEGG: 05165+2.7.1.153;Reactome: R-HSA-1660499;KEGG: 04151+2.7.1.153;KEGG: 04070+2.7.1.153;KEGG: 00562+2.7.1.153;KEGG: 04150+2.7.1.153;Reactome: R-HSA-9027276;KEGG: 05170+2.7.1.153	"Human cytomegalovirus infection";"3-phosphoinositide biosynthesis";"Human papillomavirus infection";"Synthesis of PIPs at the plasma membrane";"PI3K-Akt signaling pathway";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"mTOR signaling pathway";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"Human immunodeficiency virus 1 infection"
XP_053965062.1	9	MetaCyc: PWY-7112;MetaCyc: PWY-7533;KEGG: 00982+2.5.1.18;KEGG: 00983+2.5.1.18;KEGG: 00480+2.5.1.18;MetaCyc: PWY-4061;KEGG: 00980+2.5.1.18;Reactome: R-HSA-156590;MetaCyc: PWY-6842	"4-hydroxy-2-nonenal detoxification";"Gliotoxin biosynthesis";"Drug metabolism - cytochrome P450";"Drug metabolism - other enzymes";"Glutathione metabolism";"Glutathione-mediated detoxification I";"Metabolism of xenobiotics by cytochrome P450";"Glutathione conjugation";"Glutathione-mediated detoxification II"
XP_053965695.1	1	Reactome: R-HSA-71262	"Carnitine synthesis"
XP_053959588.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053959919.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053966227.1	10	KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;MetaCyc: PWY-6807;Reactome: R-HSA-2160916;KEGG: 00600+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2206292	"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Neutrophil degranulation";"HS-GAG degradation";"Xyloglucan degradation II (exoglucanase)";"Hyaluronan uptake and degradation";"Sphingolipid metabolism";"Galactose metabolism";"Other glycan degradation";"MPS VII - Sly syndrome"
XP_053965754.1	4	Reactome: R-HSA-4755583;Reactome: R-HSA-446199;MetaCyc: PWY-6129;KEGG: 00510+2.7.1.108	"Defective DOLK causes DOLK-CDG (CDG-1m)";"Synthesis of Dolichyl-phosphate";"Dolichol and dolichyl phosphate biosynthesis";"N-Glycan biosynthesis"
XP_053957297.1	5	MetaCyc: PWY-6892;MetaCyc: PWY-6891;KEGG: 00730+2.2.1.7;KEGG: 00900+2.2.1.7;MetaCyc: PWY-7560	"Thiazole biosynthesis I (facultative anaerobic bacteria)";"Thiazole biosynthesis II (aerobic bacteria)";"Thiamine metabolism";"Terpenoid backbone biosynthesis";"Methylerythritol phosphate pathway II"
XP_053965170.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053969145.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053960645.1	9	Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-1368108;Reactome: R-HSA-5617472;Reactome: R-HSA-400206;Reactome: R-HSA-2426168;Reactome: R-HSA-400253	"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of lipid metabolism by PPARalpha";"Activation of gene expression by SREBF (SREBP)";"Circadian Clock"
XP_053966356.1	3	Reactome: R-HSA-6784531;MetaCyc: PWY-6689;MetaCyc: PWY-7803	"tRNA processing in the nucleus";"Trna splicing I";"Trna splicing II"
XP_053948725.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053962624.1	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.9	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053947437.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053956815.1	3	KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Triglyceride biosynthesis";"Glycerol degradation I"
XP_053954835.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053965178.1	7	KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053967738.1	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
XP_053964814.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-9033500	"Peroxisomal protein import";"TYSND1 cleaves peroxisomal proteins"
XP_053949574.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053960339.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053958463.1	7	Reactome: R-HSA-9023661;Reactome: R-HSA-9018896;Reactome: R-HSA-9018676;Reactome: R-HSA-6798695;Reactome: R-HSA-2142691;Reactome: R-HSA-9018681;Reactome: R-HSA-9020265	"Biosynthesis of E-series 18(R)-resolvins";"Biosynthesis of E-series 18(S)-resolvins";"Biosynthesis of D-series resolvins";"Neutrophil degranulation";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Biosynthesis of protectins";"Biosynthesis of aspirin-triggered D-series resolvins"
XP_053958799.1	10	Reactome: R-HSA-611105;Reactome: R-HSA-9627069;Reactome: R-HSA-111463;Reactome: R-HSA-3299685;Reactome: R-HSA-2151201;Reactome: R-HSA-111458;Reactome: R-HSA-5628897;Reactome: R-HSA-111464;Reactome: R-HSA-111459;Reactome: R-HSA-111457	"Respiratory electron transport";"Regulation of the apoptosome activity";"SMAC (DIABLO) binds to IAPs";"Detoxification of Reactive Oxygen Species";"Transcriptional activation of mitochondrial biogenesis";"Formation of apoptosome";"TP53 Regulates Metabolic Genes";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Activation of caspases through apoptosome-mediated cleavage";"Release of apoptotic factors from the mitochondria"
XP_053964491.1	5	KEGG: 00860+2.3.1.37;MetaCyc: PWY-7536;KEGG: 00260+2.3.1.37;Reactome: R-HSA-189451;MetaCyc: PWY-5189	"Porphyrin and chlorophyll metabolism";"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Glycine, serine and threonine metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)"
XP_053957690.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053963936.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053960361.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053967141.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_053957175.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053966316.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053965537.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053962830.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053965714.1	9	Reactome: R-HSA-174430;Reactome: R-HSA-69183;Reactome: R-HSA-68962;Reactome: R-HSA-69091;Reactome: R-HSA-174411;Reactome: R-HSA-69205;Reactome: R-HSA-68952;Reactome: R-HSA-113501;Reactome: R-HSA-69166	"Telomere C-strand synthesis initiation";"Processive synthesis on the lagging strand";"Activation of the pre-replicative complex";"Polymerase switching";"Polymerase switching on the C-strand of the telomere";"G1/S-Specific Transcription";"DNA replication initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Removal of the Flap Intermediate"
XP_053956675.1	5	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport"
XP_053953943.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053946205.1	11	Reactome: R-HSA-8851680;MetaCyc: PWY-6606;KEGG: 00230+1.17.1.4;MetaCyc: PWY-5497;MetaCyc: PWY-6607;MetaCyc: PWY-6608;Reactome: R-HSA-74259;MetaCyc: PWY-6538;MetaCyc: PWY-5695;MetaCyc: PWY-6999;MetaCyc: PWY-6596	"Butyrophilin (BTN) family interactions";"Guanosine nucleotides degradation II";"Purine metabolism";"Purine nucleobases degradation II (anaerobic)";"Guanosine nucleotides degradation I";"Guanosine nucleotides degradation III";"Purine catabolism";"Caffeine degradation III (bacteria, via demethylation)";"Inosine 5'-phosphate degradation";"Theophylline degradation";"Adenosine nucleotides degradation I"
XP_053957427.1	2	Reactome: R-HSA-8873719;Reactome: R-HSA-6803205	"RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"
XP_053947894.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053955799.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7619;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-6433;MetaCyc: PWY-7602	"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"
XP_053957348.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053959510.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053958735.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-194840	"RAB GEFs exchange GTP for GDP on RABs";"Rho GTPase cycle"
XP_053950703.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053959973.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
XP_053956464.1	6	Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids"
XP_053950083.1	2	Reactome: R-HSA-8869496;Reactome: R-HSA-1268020	"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation";"Mitochondrial protein import"
XP_053967202.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053961770.1	2	Reactome: R-HSA-2299718;Reactome: R-HSA-2514853	"Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes"
XP_053967209.1	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
XP_053945725.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7619;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-6433;MetaCyc: PWY-7602	"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"
XP_053954899.1	5	KEGG: 00240+6.3.4.2;Reactome: R-HSA-499943;MetaCyc: PWY-7185;MetaCyc: PWY-7176;MetaCyc: PWY-7177	"Pyrimidine metabolism";"Interconversion of nucleotide di- and triphosphates";"UTP and CTP dephosphorylation I";"UTP and CTP de novo biosynthesis";"UTP and CTP dephosphorylation II"
XP_053966386.1	9	MetaCyc: PWY-6146;KEGG: 00720+6.4.1.1;MetaCyc: PWY-6142;KEGG: 00620+6.4.1.1;Reactome: R-HSA-196780;MetaCyc: PWY-8086;Reactome: R-HSA-70263;Reactome: R-HSA-3371599;KEGG: 00020+6.4.1.1	"Methanobacterium thermoautotrophicum biosynthetic metabolism";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pyruvate metabolism";"Biotin transport and metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis";"Defective HLCS causes multiple carboxylase deficiency";"Citrate cycle (TCA cycle)"
XP_053962971.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_053961154.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053947411.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_053962112.1	3	KEGG: 04660+2.7.10.2;Reactome: R-HSA-4420097;Reactome: R-HSA-391160	"T cell receptor signaling pathway";"VEGFA-VEGFR2 Pathway";"Signal regulatory protein family interactions"
XP_053955371.1	1	Reactome: R-HSA-4419969	"Depolymerisation of the Nuclear Lamina"
XP_053966003.1	1	KEGG: 00970+6.1.1.22	"Aminoacyl-tRNA biosynthesis"
XP_053949843.1	3	Reactome: R-HSA-4724325;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.265	"Defective ALG8 causes ALG8-CDG (CDG-1h)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis"
XP_053964456.1	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
XP_053946905.1	6	KEGG: 00010+5.4.2.11;MetaCyc: PWY-5484;MetaCyc: PWY-1622;KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;KEGG: 00680+5.4.2.11	"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation I (serine pathway)";"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Methane metabolism"
XP_053949020.1	2	Reactome: R-HSA-4570571;Reactome: R-HSA-446193	"Defective RFT1 causes RFT1-CDG (CDG-1n)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
XP_053947317.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_053949041.1	3	Reactome: R-HSA-74217;MetaCyc: PWY-6596;KEGG: 00230+3.5.4.6	"Purine salvage";"Adenosine nucleotides degradation I";"Purine metabolism"
XP_053966779.1	83	Reactome: R-HSA-2424491;Reactome: R-HSA-8983432;Reactome: R-HSA-5654693;Reactome: R-HSA-112412;Reactome: R-HSA-6811558;Reactome: R-HSA-8875555;Reactome: R-HSA-983695;Reactome: R-HSA-5654700;Reactome: R-HSA-8853338;Reactome: R-HSA-5654706;Reactome: R-HSA-5654712;Reactome: R-HSA-210993;Reactome: R-HSA-9645135;Reactome: R-HSA-8865999;Reactome: R-HSA-5654710;Reactome: R-HSA-1433559;Reactome: R-HSA-912631;Reactome: R-HSA-391160;Reactome: R-HSA-5663213;Reactome: R-HSA-74751;Reactome: R-HSA-389359;Reactome: R-HSA-2871796;Reactome: R-HSA-186763;Reactome: R-HSA-5654733;Reactome: R-HSA-5654689;Reactome: R-HSA-1839117;Reactome: R-HSA-2219530;Reactome: R-HSA-512988;Reactome: R-HSA-5655302;Reactome: R-HSA-8875656;Reactome: R-HSA-9027284;Reactome: R-HSA-8856825;Reactome: R-HSA-2428933;Reactome: R-HSA-5654732;Reactome: R-HSA-74749;Reactome: R-HSA-9028731;Reactome: R-HSA-8853659;Reactome: R-HSA-8851907;Reactome: R-HSA-5655253;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-9026519;Reactome: R-HSA-2029482;Reactome: R-HSA-5654720;Reactome: R-HSA-9634285;Reactome: R-HSA-9607240;Reactome: R-HSA-1295596;Reactome: R-HSA-179812;Reactome: R-HSA-167044;Reactome: R-HSA-5654719;Reactome: R-HSA-2730905;Reactome: R-HSA-5637810;Reactome: R-HSA-5654699;Reactome: R-HSA-8856828;Reactome: R-HSA-5654727;Reactome: R-HSA-1433557;Reactome: R-HSA-5654726;Reactome: R-HSA-5655291;Reactome: R-HSA-1963640;Reactome: R-HSA-912526;Reactome: R-HSA-1963642;Reactome: R-HSA-8853334;Reactome: R-HSA-2871809;Reactome: R-HSA-5654704;Reactome: R-HSA-8875360;Reactome: R-HSA-354194;Reactome: R-HSA-5654695;Reactome: R-HSA-5654688;Reactome: R-HSA-9664565;Reactome: R-HSA-1250347;Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-180292;Reactome: R-HSA-8851805;Reactome: R-HSA-180336;Reactome: R-HSA-6807004;Reactome: R-HSA-9028335;Reactome: R-HSA-182971;Reactome: R-HSA-1250196;Reactome: R-HSA-9034864;Reactome: R-HSA-1236382;Reactome: R-HSA-388841;Reactome: R-HSA-1257604	"DAP12 signaling";"Interleukin-15 signaling";"FRS-mediated FGFR1 signaling";"SOS-mediated signalling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"MET activates RAP1 and RAC1";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"FRS-mediated FGFR2 signaling";"Signaling by FGFR3 point mutants in cancer";"FRS-mediated FGFR3 signaling";"FRS-mediated FGFR4 signaling";"Tie2 Signaling";"STAT5 Activation";"MET activates PTPN11";"PI-3K cascade:FGFR3";"Regulation of KIT signaling";"Regulation of signaling by CBL";"Signal regulatory protein family interactions";"RHO GTPases Activate WASPs and WAVEs";"Insulin receptor signalling cascade";"CD28 dependent Vav1 pathway";"FCERI mediated MAPK activation";"Downstream signal transduction";"Negative regulation of FGFR4 signaling";"PI-3K cascade:FGFR1";"Signaling by cytosolic FGFR1 fusion mutants";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Signaling by FGFR1 in disease";"MET receptor recycling";"Erythropoietin activates RAS";"Cargo recognition for clathrin-mediated endocytosis";"SHC-related events triggered by IGF1R";"Negative regulation of FGFR3 signaling";"Signal attenuation";"Activated NTRK2 signals through FRS2 and FRS3";"RET signaling";"MET activates PI3K/AKT signaling";"Signaling by FGFR2 in disease";"EGFR Transactivation by Gastrin";"PI3K Cascade";"Activated NTRK2 signals through RAS";"Regulation of actin dynamics for phagocytic cup formation";"PI-3K cascade:FGFR4";"Constitutive Signaling by Overexpressed ERBB2";"FLT3 Signaling";"Spry regulation of FGF signaling";"GRB2 events in EGFR signaling";"Signalling to RAS";"SHC-mediated cascade:FGFR4";"Role of LAT2/NTAL/LAB on calcium mobilization";"Constitutive Signaling by EGFRvIII";"SHC-mediated cascade:FGFR2";"Clathrin-mediated endocytosis";"Negative regulation of FGFR2 signaling";"Signaling by SCF-KIT";"Negative regulation of FGFR1 signaling";"Signaling by FGFR4 in disease";"GRB2 events in ERBB2 signaling";"Interleukin receptor SHC signaling";"PI3K events in ERBB2 signaling";"Signaling by FGFR3 fusions in cancer";"FCERI mediated Ca+2 mobilization";"SHC-mediated cascade:FGFR3";"InlB-mediated entry of Listeria monocytogenes into host cell";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"PI-3K cascade:FGFR2";"SHC-mediated cascade:FGFR1";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB4 signaling";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"GAB1 signalosome";"MET activates RAS signaling";"SHC1 events in EGFR signaling";"Negative regulation of MET activity";"Activated NTRK2 signals through PI3K";"EGFR downregulation";"SHC1 events in ERBB2 signaling";"Activated NTRK3 signals through RAS";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Costimulation by the CD28 family";"PIP3 activates AKT signaling"
XP_053966801.1	4	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-1268020	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial protein import"
XP_053950924.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053967902.1	2	Reactome: R-HSA-5576894;Reactome: R-HSA-1296072	"Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels"
XP_053952026.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950160.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_053952245.1	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_053964416.1	3	Reactome: R-HSA-6804760;Reactome: R-HSA-191859;Reactome: R-HSA-3214858	"Regulation of TP53 Activity through Methylation";"snRNP Assembly";"RMTs methylate histone arginines"
XP_053947451.1	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
XP_053965017.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053950533.1	5	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-2132295;Reactome: R-HSA-5620924	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"MHC class II antigen presentation";"Intraflagellar transport"
XP_053958347.1	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
XP_053964533.1	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
XP_053961279.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053967538.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053949150.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053955374.1	3	Reactome: R-HSA-3322077;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.11	"Glycogen synthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism"
XP_053955636.1	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
XP_053950416.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053953708.1	5	Reactome: R-HSA-168164;Reactome: R-HSA-166166;Reactome: R-HSA-936964;Reactome: R-HSA-937072;Reactome: R-HSA-937041	"Toll Like Receptor 3 (TLR3) Cascade";"MyD88-independent TLR4 cascade";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IKK complex recruitment mediated by RIP1"
XP_053967700.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053966817.1	7	Reactome: R-HSA-2029485;KEGG: 00565+3.1.4.4;Reactome: R-HSA-1483148;MetaCyc: PWY-7039;KEGG: 00564+3.1.4.4;Reactome: R-HSA-1483166;MetaCyc: PWY-3561	"Role of phospholipids in phagocytosis";"Ether lipid metabolism";"Synthesis of PG";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Synthesis of PA";"Choline biosynthesis III"
XP_053963206.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053948525.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053953163.1	4	MetaCyc: PWY-6557;KEGG: 00534+2.4.2.26;KEGG: 00532+2.4.2.26;Reactome: R-HSA-1971475	"Glycosaminoglycan-protein linkage region biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate";"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053945380.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053962398.1	6	KEGG: 04070+2.7.11.13;Reactome: R-HSA-114516;Reactome: R-HSA-416993;Reactome: R-HSA-5099900;Reactome: R-HSA-76005;Reactome: R-HSA-418597	"Phosphatidylinositol signaling system";"Disinhibition of SNARE formation";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD4";"Response to elevated platelet cytosolic Ca2+";"G alpha (z) signalling events"
XP_053964924.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429958	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease"
XP_053952293.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053969291.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053948105.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_053956373.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053965737.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053949633.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053967177.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_053965514.1	1	Reactome: R-HSA-198933	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
XP_053948310.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053952165.1	3	Reactome: R-HSA-420029;MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_053962022.1	4	Reactome: R-HSA-1912420;Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-936837	"Pre-NOTCH Processing in Golgi";"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Ion transport by P-type ATPases"
XP_053948318.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053968034.1	7	MetaCyc: PWY-7839;MetaCyc: PWY-7836;MetaCyc: PWY-5129;MetaCyc: PWY-7841;Reactome: R-HSA-1660662;MetaCyc: PWY-7838;KEGG: 00600+2.4.1.80	"Lacto-series glycosphingolipids biosynthesis";"Ganglio-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)";"Neolacto-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism";"Globo-series glycosphingolipids biosynthesis";"Sphingolipid metabolism"
XP_053961979.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053966553.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053958015.1	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
XP_053965664.1	6	Reactome: R-HSA-8874081;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814;Reactome: R-HSA-2022090;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Collagen chain trimerization";"Collagen degradation";"Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures";"Non-integrin membrane-ECM interactions"
XP_053959829.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053961283.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053950465.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053962274.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_053952993.1	15	Reactome: R-HSA-9018519;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-2173796;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-176034;Reactome: R-HSA-6807505;Reactome: R-HSA-167246	"Estrogen-dependent gene expression";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Interactions of Tat with host cellular proteins";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript"
XP_053950647.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_053968475.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053959147.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_053964703.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053967295.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053953700.1	5	Reactome: R-HSA-937041;Reactome: R-HSA-937072;Reactome: R-HSA-936964;Reactome: R-HSA-166166;Reactome: R-HSA-168164	"IKK complex recruitment mediated by RIP1";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade"
XP_053949158.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_053967530.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053950921.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053951388.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053955990.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053966804.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_053953538.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053970190.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
XP_053962390.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053958420.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053955697.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053949895.1	6	MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1;MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+6.3.1.5	"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism"
XP_053955085.1	3	Reactome: R-HSA-1237112;KEGG: 00270+1.13.11.54;MetaCyc: PWY-4361	"Methionine salvage pathway";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053965393.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053964896.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053953010.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_053966572.1	7	KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053961953.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053945350.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053959174.1	6	Reactome: R-HSA-9010553;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-975957;Reactome: R-HSA-159236;Reactome: R-HSA-73856	"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination"
XP_053965475.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_053949839.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
XP_053949180.1	3	KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3	"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis"
XP_053961578.1	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
XP_053958697.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_053956319.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053959718.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053950814.1	2	Reactome: R-HSA-5576886;Reactome: R-HSA-1299308	"Phase 4 - resting membrane potential";"Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)"
XP_053958298.1	27	Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-180910;Reactome: R-HSA-159230;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-168325	"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP Dependant Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis"
XP_053954473.1	2	Reactome: R-HSA-5689896;Reactome: R-HSA-936440	"Ovarian tumor domain proteases";"Negative regulators of DDX58/IFIH1 signaling"
XP_053960835.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053961137.1	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
XP_053969216.1	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-8876198	"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"RAB GEFs exchange GTP for GDP on RABs"
XP_053949861.1	12	KEGG: 00130+1.14.99.60;MetaCyc: PWY-5857;MetaCyc: PWY-5873;MetaCyc: PWY-5855;MetaCyc: PWY-7230;MetaCyc: PWY-5870;MetaCyc: PWY-5871;MetaCyc: PWY-5872;MetaCyc: PWY-6708;MetaCyc: PWY-7233;MetaCyc: PWY-5856;Reactome: R-HSA-2142789	"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis"
XP_053968664.1	4	Reactome: R-HSA-1170546;Reactome: R-HSA-2586552;Reactome: R-HSA-983231;Reactome: R-HSA-982772	"Prolactin receptor signaling";"Signaling by Leptin";"Factors involved in megakaryocyte development and platelet production";"Growth hormone receptor signaling"
XP_053948438.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053961196.1	2	Reactome: R-HSA-532668;Reactome: R-HSA-6798695	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Neutrophil degranulation"
XP_053953261.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053945105.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053967144.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_053950807.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053963478.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_053959710.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053966644.1	2	MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21	"Mitochondrial L-carnitine shuttle";"Fatty acid degradation"
XP_053950503.1	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
XP_053950549.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_053961913.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053966887.1	3	Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807	"Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism"
XP_053966862.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_053966869.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053954546.1	9	Reactome: R-HSA-1971475;Reactome: R-HSA-4420332;Reactome: R-HSA-3656253;Reactome: R-HSA-975634;Reactome: R-HSA-3560801;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096;Reactome: R-HSA-2022928;Reactome: R-HSA-3560783	"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Retinoid metabolism and transport";"Defective B3GAT3 causes JDSSDHD";"Defective EXT2 causes exostoses 2";"HS-GAG degradation";"HS-GAG biosynthesis";"Defective B4GALT7 causes EDS, progeroid type"
XP_053969448.1	2	KEGG: 00513+2.4.1.142;KEGG: 00510+2.4.1.142	"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
XP_053951525.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053965643.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053961727.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053962640.1	1	Reactome: R-HSA-212300	"PRC2 methylates histones and DNA"
XP_053949571.1	3	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053958998.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-8949215	"Ub-specific processing proteases";"Mitochondrial calcium ion transport"
XP_053953018.1	5	MetaCyc: PWY-6289;MetaCyc: PWY-6012-1;Reactome: R-HSA-199220;MetaCyc: PWY-6012;KEGG: 00770+2.7.8.7	"Petrobactin biosynthesis";"Acyl carrier protein activation";"Vitamin B5 (pantothenate) metabolism";"Acyl carrier protein metabolism";"Pantothenate and CoA biosynthesis"
XP_053950854.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053954467.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053947865.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_053962621.1	3	Reactome: R-HSA-5656121;Reactome: R-HSA-5655862;Reactome: R-HSA-110312	"Translesion synthesis by POLI";"Translesion synthesis by POLK";"Translesion synthesis by REV1"
XP_053951358.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053950397.1	1	Reactome: R-HSA-211897	"Cytochrome P450 - arranged by substrate type"
XP_053946429.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053965466.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_053961282.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053946165.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053950208.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053959823.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_053963946.1	2	KEGG: 00511+3.2.1.96;Reactome: R-HSA-532668	"Other glycan degradation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
XP_053969725.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_053951370.1	4	KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219	"Purine metabolism";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis"
XP_053949057.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053945370.1	3	Reactome: R-HSA-6804760;Reactome: R-HSA-2299718;Reactome: R-HSA-3214841	"Regulation of TP53 Activity through Methylation";"Condensation of Prophase Chromosomes";"PKMTs methylate histone lysines"
XP_053966559.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053962840.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053962984.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053966552.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053965809.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053961325.1	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
XP_053966288.1	2	Reactome: R-HSA-202433;Reactome: R-HSA-376176	"Generation of second messenger molecules";"Signaling by ROBO receptors"
XP_053950900.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053957246.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053957025.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053947566.1	56	Reactome: R-HSA-69481;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-450408;Reactome: R-HSA-4608870;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-9604323;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-202424	"G2/M Checkpoints";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Asymmetric localization of PCP proteins";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Negative regulation of NOTCH4 signaling";"Hedgehog 'on' state";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Downstream TCR signaling"
XP_053966662.1	5	Reactome: R-HSA-390450;Reactome: R-HSA-6814122;Reactome: R-HSA-389957;Reactome: R-HSA-390471;Reactome: R-HSA-389960	"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC"
XP_053953721.1	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
XP_053965392.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053952992.1	15	Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-176034;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-2173796;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-9018519	"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"Interactions of Tat with host cellular proteins";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Estrogen-dependent gene expression"
XP_053964702.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053949511.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053950607.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_053959107.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053964871.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053964709.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053961967.1	7	Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-73780	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation"
XP_053963025.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053953187.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053947320.1	4	Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_053964073.1	2	Reactome: R-HSA-525793;Reactome: R-HSA-373752	"Myogenesis";"Netrin-1 signaling"
XP_053953748.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053969135.1	6	Reactome: R-HSA-4411364;Reactome: R-HSA-3769402;Reactome: R-HSA-8951430;Reactome: R-HSA-4086398;Reactome: R-HSA-4641265;Reactome: R-HSA-201722	"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex";"RUNX3 regulates WNT signaling";"Ca2+ pathway";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex"
XP_053958307.1	6	Reactome: R-HSA-913709;MetaCyc: PWY-7290;KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632;MetaCyc: PWY-7433;KEGG: 00512+2.4.1.122	"O-linked glycosylation of mucins";"Escherichia coli serotype O86 O-antigen biosynthesis";"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Mucin core 1 and core 2 O-glycosylation";"Mucin type O-glycan biosynthesis"
XP_053946116.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053964539.1	2	Reactome: R-HSA-8873719;Reactome: R-HSA-6803205	"RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"
XP_053947341.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053959021.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_053951994.1	2	Reactome: R-HSA-444821;Reactome: R-HSA-418555	"Relaxin receptors";"G alpha (s) signalling events"
XP_053965020.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_053950200.1	10	Reactome: R-HSA-8939243;Reactome: R-HSA-445144;Reactome: R-HSA-8934903;Reactome: R-HSA-6814122;Reactome: R-HSA-2514853;Reactome: R-HSA-201688;Reactome: R-HSA-6804756;Reactome: R-HSA-1483191;Reactome: R-HSA-8948751;Reactome: R-HSA-6798695	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Signal transduction by L1";"Receptor Mediated Mitophagy";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Condensation of Prometaphase Chromosomes";"WNT mediated activation of DVL";"Regulation of TP53 Activity through Phosphorylation";"Synthesis of PC";"Regulation of PTEN stability and activity";"Neutrophil degranulation"
XP_053962023.1	4	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-1912420	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi"
XP_053961550.1	6	Reactome: R-HSA-381426;Reactome: R-HSA-201722;Reactome: R-HSA-2173796;Reactome: R-HSA-5626467;Reactome: R-HSA-8957275;Reactome: R-HSA-3769402	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Formation of the beta-catenin:TCF transactivating complex";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"RHO GTPases activate IQGAPs";"Post-translational protein phosphorylation";"Deactivation of the beta-catenin transactivating complex"
XP_053964561.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053958354.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053956379.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053950874.1	5	KEGG: 00270+6.3.2.3;MetaCyc: PWY-8043;KEGG: 00480+6.3.2.3;Reactome: R-HSA-174403;Reactome: R-HSA-5579006	"Cysteine and methionine metabolism";"Ophthalmate biosynthesis";"Glutathione metabolism";"Glutathione synthesis and recycling";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)"
XP_053955075.1	1	Reactome: R-HSA-68962	"Activation of the pre-replicative complex"
XP_053949632.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053962848.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_053966863.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_053951145.1	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
XP_053962954.1	3	MetaCyc: PWY-7420;Reactome: R-HSA-426048;KEGG: 00561+3.1.1.23	"Monoacylglycerol metabolism (yeast)";"Arachidonate production from DAG";"Glycerolipid metabolism"
XP_053964696.1	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
XP_053966589.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053949695.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053968020.1	2	Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
XP_053947686.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053962214.1	6	Reactome: R-HSA-9010553;Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-975957;Reactome: R-HSA-72187	"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA 3'-end processing"
XP_053949069.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_053966604.1	4	KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193	"Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I"
XP_053950509.1	7	Reactome: R-HSA-156711;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-69202	"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin E associated events during G1/S transition"
XP_053948378.1	15	Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167242;Reactome: R-HSA-167246;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-9603505;Reactome: R-HSA-113418	"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Tat-mediated elongation of the HIV-1 transcript";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"NTRK3 as a dependence receptor";"Formation of the Early Elongation Complex"
XP_053964059.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053963338.1	2	Reactome: R-HSA-2514853;Reactome: R-HSA-2299718	"Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes"
XP_053956756.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053950502.1	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
XP_053961259.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053954605.1	7	Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912	"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane"
XP_053959622.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053950122.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053949596.1	4	Reactome: R-HSA-1799339;Reactome: R-HSA-381771;Reactome: R-HSA-400511;Reactome: R-HSA-422085	"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin"
XP_053962907.1	4	KEGG: 00230+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3	"Purine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism"
XP_053950129.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_053965864.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_053965642.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053967157.1	10	MetaCyc: PWY-922;MetaCyc: PWY-7571;KEGG: 00072+2.3.3.10;Reactome: R-HSA-1989781;KEGG: 00280+2.3.3.10;KEGG: 00650+2.3.3.10;MetaCyc: PWY-6174;MetaCyc: PWY-7391;KEGG: 00900+2.3.3.10;MetaCyc: PWY-7524	"Mevalonate pathway I";"Ferrichrome A biosynthesis";"Synthesis and degradation of ketone bodies";"PPARA activates gene expression";"Valine, leucine and isoleucine degradation";"Butanoate metabolism";"Mevalonate pathway II (archaea)";"Isoprene biosynthesis II (engineered)";"Terpenoid backbone biosynthesis";"Mevalonate pathway III (archaea)"
XP_053965649.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053952176.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053962254.1	2	KEGG: 00260+2.3.1.29;Reactome: R-HSA-8849175	"Glycine, serine and threonine metabolism";"Threonine catabolism"
XP_053947691.1	3	Reactome: R-HSA-156590;KEGG: 00680+3.1.2.12;MetaCyc: PWY-1801	"Glutathione conjugation";"Methane metabolism";"Formaldehyde oxidation II (glutathione-dependent)"
XP_053967233.1	11	Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912	"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane"
XP_053963488.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053962914.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053966573.1	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
XP_053948294.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_053947474.1	7	KEGG: 00970+6.1.1.17;KEGG: 00860+6.1.1.17;Reactome: R-HSA-6782315;MetaCyc: PWY-5188;KEGG: 00970+6.1.1.15;Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Porphyrin and chlorophyll metabolism";"tRNA modification in the nucleus and cytosol";"Tetrapyrrole biosynthesis I (from glutamate)";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
XP_053969400.1	4	Reactome: R-HSA-2408557;KEGG: 00970+2.9.1.2;MetaCyc: PWY-6281;KEGG: 00450+2.9.1.2	"Selenocysteine synthesis";"Aminoacyl-tRNA biosynthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocompound metabolism"
XP_053961952.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053949833.1	4	Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
XP_053955401.1	4	Reactome: R-HSA-1632852;Reactome: R-HSA-936440;Reactome: R-HSA-8934903;Reactome: R-HSA-5205685	"Macroautophagy";"Negative regulators of DDX58/IFIH1 signaling";"Receptor Mediated Mitophagy";"Pink/Parkin Mediated Mitophagy"
XP_053949537.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053966039.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053950476.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053965335.1	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
XP_053961959.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053968028.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053966061.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053964637.1	13	MetaCyc: PWY-7709;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7182;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-5123;MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-6383;MetaCyc: PWY-5122;MetaCyc: PWY-6859;MetaCyc: PWY-7721	"(3R)-linalool biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"Linalool biosynthesis I";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"All-trans-farnesol biosynthesis";"Methyl phomopsenoate biosynthesis"
XP_053958745.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053954472.1	2	Reactome: R-HSA-936440;Reactome: R-HSA-5689896	"Negative regulators of DDX58/IFIH1 signaling";"Ovarian tumor domain proteases"
XP_053963330.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053950732.1	27	Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-168333;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-180910;Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-4570464	"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"Vpr-mediated nuclear import of PICs";"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins"
XP_053945965.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_053947377.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387	"Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling"
XP_053967540.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053956036.1	5	Reactome: R-HSA-4719360;Reactome: R-HSA-162699;Reactome: R-HSA-4719377;Reactome: R-HSA-162710;Reactome: R-HSA-4717374	"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Synthesis of dolichyl-phosphate mannose";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Synthesis of glycosylphosphatidylinositol (GPI)";"Defective DPM1 causes DPM1-CDG (CDG-1e)"
XP_053958431.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053949034.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053962068.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053945956.1	14	Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7619;MetaCyc: PWY-7724;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-5080	"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Sciadonate biosynthesis";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I"
XP_053950930.1	3	Reactome: R-HSA-1614603;Reactome: R-HSA-2408508;Reactome: R-HSA-1614558	"Cysteine formation from homocysteine";"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Degradation of cysteine and homocysteine"
XP_053945216.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053959860.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053953027.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053958396.1	42	Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-3214815;Reactome: R-HSA-5250924;Reactome: R-HSA-3214858;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-5334118;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-977225;Reactome: R-HSA-5693571;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-9018519;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-5693607;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-1912408;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-110331;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-2299718;Reactome: R-HSA-427413	"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"HDACs deacetylate histones";"B-WICH complex positively regulates rRNA expression";"RMTs methylate histone arginines";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"DNA methylation";"Packaging Of Telomere Ends";"Meiotic synapsis";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Amyloid fiber formation";"Nonhomologous End-Joining (NHEJ)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Estrogen-dependent gene expression";"Meiotic recombination";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Processing of DNA double-strand break ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Pre-NOTCH Transcription and Translation";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Cleavage of the damaged purine";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"Condensation of Prophase Chromosomes";"NoRC negatively regulates rRNA expression"
XP_053962426.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053958806.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_053948991.1	6	MetaCyc: PWY-6368;Reactome: R-HSA-1660516;KEGG: 04070+3.1.3.66;KEGG: 00562+3.1.3.66;Reactome: R-HSA-1660499;Reactome: R-HSA-1855183	"3-phosphoinositide degradation";"Synthesis of PIPs at the early endosome membrane";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of PIPs at the plasma membrane";"Synthesis of IP2, IP, and Ins in the cytosol"
XP_053959578.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053966601.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053965077.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053965839.1	6	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-6798695	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"Neutrophil degranulation"
XP_053950681.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053958462.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053962951.1	3	Reactome: R-HSA-426048;MetaCyc: PWY-7420;KEGG: 00561+3.1.1.23	"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)";"Glycerolipid metabolism"
XP_053964761.1	3	Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13;Reactome: R-HSA-418597	"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"G alpha (z) signalling events"
XP_053950238.1	26	Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-9013508;Reactome: R-HSA-1368082;Reactome: R-HSA-1234158;Reactome: R-HSA-5621575;Reactome: R-HSA-3899300;Reactome: R-HSA-3134973;Reactome: R-HSA-400253;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-381340;Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-9617629;Reactome: R-HSA-3371568;Reactome: R-HSA-1989781;Reactome: R-HSA-8866907;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-918233;Reactome: R-HSA-933541;Reactome: R-HSA-9018519;Reactome: R-HSA-9614657	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"NOTCH3 Intracellular Domain Regulates Transcription";"RORA activates gene expression";"Regulation of gene expression by Hypoxia-inducible Factor";"CD209 (DC-SIGN) signaling";"SUMOylation of transcription cofactors";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Circadian Clock";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"Attenuation phase";"PPARA activates gene expression";"Activation of the TFAP2 (AP-2) family of transcription factors";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF3-dependent IRF activation pathway";"TRAF6 mediated IRF7 activation";"Estrogen-dependent gene expression";"FOXO-mediated transcription of cell death genes"
XP_053951916.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053966759.1	6	Reactome: R-HSA-428930;Reactome: R-HSA-456926;Reactome: R-HSA-399997;Reactome: R-HSA-416476;Reactome: R-HSA-418592;Reactome: R-HSA-434316	"Thromboxane signalling through TP receptor";"Thrombin signalling through proteinase activated receptors (PARs)";"Acetylcholine regulates insulin secretion";"G alpha (q) signalling events";"ADP signalling through P2Y purinoceptor 1";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"
XP_053949643.1	11	Reactome: R-HSA-418597;Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-164378;Reactome: R-HSA-418594;Reactome: R-HSA-5610787;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1	"G alpha (z) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"PKA activation in glucagon signalling";"G alpha (i) signalling events";"Hedgehog 'off' state";"Adenylate cyclase inhibitory pathway";"PKA activation";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"Purine metabolism"
XP_053954056.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053961623.1	18	KEGG: 00360+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00950+2.6.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-6642;MetaCyc: PWY-5913;KEGG: 00220+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00350+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00270+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00330+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-7383;MetaCyc: PWY-6638	"Phenylalanine metabolism";"Alanine, aspartate and glutamate metabolism";"Isoquinoline alkaloid biosynthesis";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"(R)-cysteate degradation";"Partial TCA cycle (obligate autotrophs)";"Arginine biosynthesis";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Tyrosine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Novobiocin biosynthesis";"Carbon fixation in photosynthetic organisms";"Cysteine and methionine metabolism";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine and proline metabolism";"Coenzyme M biosynthesis II";"Anaerobic energy metabolism (invertebrates, cytosol)";"Sulfolactate degradation III"
XP_053949602.1	1	Reactome: R-HSA-1483166	"Synthesis of PA"
XP_053960797.1	13	Reactome: R-HSA-4086398;Reactome: R-HSA-983695;Reactome: R-HSA-5218921;Reactome: R-HSA-5578775;Reactome: R-HSA-381676;Reactome: R-HSA-1489509;Reactome: R-HSA-2029485;Reactome: R-HSA-5607763;Reactome: R-HSA-139853;Reactome: R-HSA-2871809;Reactome: R-HSA-112043;Reactome: R-HSA-114508;Reactome: R-HSA-422356	"Ca2+ pathway";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"VEGFR2 mediated cell proliferation";"Ion homeostasis";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"DAG and IP3 signaling";"Role of phospholipids in phagocytosis";"CLEC7A (Dectin-1) induces NFAT activation";"Elevation of cytosolic Ca2+ levels";"FCERI mediated Ca+2 mobilization";"PLC beta mediated events";"Effects of PIP2 hydrolysis";"Regulation of insulin secretion"
XP_053950230.1	26	Reactome: R-HSA-9013508;Reactome: R-HSA-1368082;Reactome: R-HSA-1234158;Reactome: R-HSA-5621575;Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-3899300;Reactome: R-HSA-3134973;Reactome: R-HSA-400253;Reactome: R-HSA-2122947;Reactome: R-HSA-9617629;Reactome: R-HSA-3371568;Reactome: R-HSA-8941856;Reactome: R-HSA-381340;Reactome: R-HSA-2644606;Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-9018519;Reactome: R-HSA-9614657;Reactome: R-HSA-1989781;Reactome: R-HSA-8866907;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-918233;Reactome: R-HSA-933541	"NOTCH3 Intracellular Domain Regulates Transcription";"RORA activates gene expression";"Regulation of gene expression by Hypoxia-inducible Factor";"CD209 (DC-SIGN) signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"SUMOylation of transcription cofactors";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Circadian Clock";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"Attenuation phase";"RUNX3 regulates NOTCH signaling";"Transcriptional regulation of white adipocyte differentiation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Estrogen-dependent gene expression";"FOXO-mediated transcription of cell death genes";"PPARA activates gene expression";"Activation of the TFAP2 (AP-2) family of transcription factors";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF3-dependent IRF activation pathway";"TRAF6 mediated IRF7 activation"
XP_053961758.1	6	KEGG: 00512+2.4.1.122;MetaCyc: PWY-7433;KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632;MetaCyc: PWY-7290;Reactome: R-HSA-913709	"Mucin type O-glycan biosynthesis";"Mucin core 1 and core 2 O-glycosylation";"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Escherichia coli serotype O86 O-antigen biosynthesis";"O-linked glycosylation of mucins"
XP_053949584.1	16	Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-2467813;Reactome: R-HSA-8853884;Reactome: R-HSA-141430	"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Separation of Sister Chromatids";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex"
XP_053966064.1	6	MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_053945916.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053955404.1	1	Reactome: R-HSA-8964572	"Lipid particle organization"
XP_053969105.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053948291.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_053964502.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053962179.1	29	Reactome: R-HSA-73772;Reactome: R-HSA-112382;Reactome: R-HSA-5696400;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-77075;Reactome: R-HSA-6782135;Reactome: R-HSA-73762;Reactome: R-HSA-6781827;Reactome: R-HSA-167162;Reactome: R-HSA-427413;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-113418;Reactome: R-HSA-6781823;Reactome: R-HSA-72086;Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-5696395	"RNA Polymerase I Promoter Escape";"Formation of RNA Pol II elongation complex";"Dual Incision in GG-NER";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"Dual incision in TC-NER";"RNA Polymerase I Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II HIV Promoter Escape";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Formation of the Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"mRNA Capping";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER"
XP_053967548.1	6	MetaCyc: PWY-922;KEGG: 00900+2.7.1.36;MetaCyc: PWY-6174;Reactome: R-HSA-2426168;MetaCyc: PWY-7391;Reactome: R-HSA-191273	"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Mevalonate pathway II (archaea)";"Activation of gene expression by SREBF (SREBP)";"Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis"
XP_053953540.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053965063.1	6	Reactome: R-HSA-5099900;Reactome: R-HSA-416993;Reactome: R-HSA-418597;Reactome: R-HSA-76005;Reactome: R-HSA-114516;KEGG: 04070+2.7.11.13	"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors";"G alpha (z) signalling events";"Response to elevated platelet cytosolic Ca2+";"Disinhibition of SNARE formation";"Phosphatidylinositol signaling system"
XP_053969626.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053950938.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053962060.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053960126.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053957185.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053964874.1	3	KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317	"Glycolysis / Gluconeogenesis";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)"
XP_053945291.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
XP_053954536.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053949514.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_053958311.1	6	MetaCyc: PWY-7290;Reactome: R-HSA-913709;MetaCyc: PWY-7433;KEGG: 00512+2.4.1.122;KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632	"Escherichia coli serotype O86 O-antigen biosynthesis";"O-linked glycosylation of mucins";"Mucin core 1 and core 2 O-glycosylation";"Mucin type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)"
XP_053953242.1	7	Reactome: R-HSA-9029569;Reactome: R-HSA-3214842;Reactome: R-HSA-983231;Reactome: R-HSA-5625886;Reactome: R-HSA-9018519;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"HDMs demethylate histones";"Factors involved in megakaryocyte development and platelet production";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Estrogen-dependent gene expression";"HDACs deacetylate histones";"Regulation of PTEN gene transcription"
XP_053966820.1	8	Reactome: R-HSA-8953750;Reactome: R-HSA-111458;Reactome: R-HSA-111464;Reactome: R-HSA-111459;Reactome: R-HSA-6803207;Reactome: R-HSA-6798695;Reactome: R-HSA-9627069;Reactome: R-HSA-111463	"Transcriptional Regulation by E2F6";"Formation of apoptosome";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Activation of caspases through apoptosome-mediated cleavage";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Neutrophil degranulation";"Regulation of the apoptosome activity";"SMAC (DIABLO) binds to IAPs"
XP_053950561.1	3	Reactome: R-HSA-1650814;MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2	"Collagen biosynthesis and modifying enzymes";"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism"
XP_053953203.1	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
XP_053953724.1	4	Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-9010553	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs"
XP_053962981.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053966376.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053964614.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_053958457.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053962296.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_053950532.1	5	Reactome: R-HSA-5620924;Reactome: R-HSA-1445148;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"Intraflagellar transport";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053959983.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
XP_053962824.1	15	Reactome: R-HSA-2559586;Reactome: R-HSA-5685939;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-6804756;Reactome: R-HSA-5693568;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693548;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-912446	"DNA Damage/Telomere Stress Induced Senescence";"HDR through MMEJ (alt-NHEJ)";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Sensing of DNA Double Strand Breaks";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Meiotic recombination"
XP_053948327.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053946460.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053967903.1	2	Reactome: R-HSA-5576894;Reactome: R-HSA-1296072	"Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels"
XP_053960845.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053953134.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_053950871.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_053950709.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053945286.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053964607.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053950702.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053963115.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_053954086.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053949127.1	9	Reactome: R-HSA-4420097;Reactome: R-HSA-193648;Reactome: R-HSA-2871809;Reactome: R-HSA-5218920;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-2871796;Reactome: R-HSA-2029482;Reactome: R-HSA-416482	"VEGFA-VEGFR2 Pathway";"NRAGE signals death through JNK";"FCERI mediated Ca+2 mobilization";"VEGFR2 mediated vascular permeability";"Rho GTPase cycle";"GPVI-mediated activation cascade";"FCERI mediated MAPK activation";"Regulation of actin dynamics for phagocytic cup formation";"G alpha (12/13) signalling events"
XP_053951991.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_053956565.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053966789.1	83	Reactome: R-HSA-8875360;Reactome: R-HSA-354194;Reactome: R-HSA-5654695;Reactome: R-HSA-1250347;Reactome: R-HSA-9664565;Reactome: R-HSA-5654688;Reactome: R-HSA-8851805;Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-180292;Reactome: R-HSA-180336;Reactome: R-HSA-6807004;Reactome: R-HSA-9028335;Reactome: R-HSA-1236382;Reactome: R-HSA-182971;Reactome: R-HSA-9034864;Reactome: R-HSA-1250196;Reactome: R-HSA-1257604;Reactome: R-HSA-388841;Reactome: R-HSA-2029482;Reactome: R-HSA-9026519;Reactome: R-HSA-1295596;Reactome: R-HSA-179812;Reactome: R-HSA-5654720;Reactome: R-HSA-9634285;Reactome: R-HSA-9607240;Reactome: R-HSA-5637810;Reactome: R-HSA-5654699;Reactome: R-HSA-167044;Reactome: R-HSA-5654719;Reactome: R-HSA-2730905;Reactome: R-HSA-1433557;Reactome: R-HSA-8856828;Reactome: R-HSA-5654727;Reactome: R-HSA-1963640;Reactome: R-HSA-5654726;Reactome: R-HSA-5655291;Reactome: R-HSA-912526;Reactome: R-HSA-1963642;Reactome: R-HSA-8853334;Reactome: R-HSA-5654704;Reactome: R-HSA-2871809;Reactome: R-HSA-2871796;Reactome: R-HSA-186763;Reactome: R-HSA-2219530;Reactome: R-HSA-512988;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-1839117;Reactome: R-HSA-8875656;Reactome: R-HSA-5655302;Reactome: R-HSA-5654732;Reactome: R-HSA-8856825;Reactome: R-HSA-9027284;Reactome: R-HSA-2428933;Reactome: R-HSA-9028731;Reactome: R-HSA-74749;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-8853659;Reactome: R-HSA-8851907;Reactome: R-HSA-5655253;Reactome: R-HSA-2424491;Reactome: R-HSA-8983432;Reactome: R-HSA-983695;Reactome: R-HSA-8875555;Reactome: R-HSA-5654700;Reactome: R-HSA-5654693;Reactome: R-HSA-6811558;Reactome: R-HSA-112412;Reactome: R-HSA-8853338;Reactome: R-HSA-5654706;Reactome: R-HSA-9645135;Reactome: R-HSA-8865999;Reactome: R-HSA-5654712;Reactome: R-HSA-210993;Reactome: R-HSA-5654710;Reactome: R-HSA-912631;Reactome: R-HSA-389359;Reactome: R-HSA-5663213;Reactome: R-HSA-391160;Reactome: R-HSA-74751;Reactome: R-HSA-1433559	"InlB-mediated entry of Listeria monocytogenes into host cell";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"PI-3K cascade:FGFR2";"SHC1 events in ERBB4 signaling";"Signaling by ERBB2 KD Mutants";"SHC-mediated cascade:FGFR1";"MET activates RAS signaling";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"GAB1 signalosome";"SHC1 events in EGFR signaling";"Negative regulation of MET activity";"Activated NTRK2 signals through PI3K";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"EGFR downregulation";"Activated NTRK3 signals through RAS";"SHC1 events in ERBB2 signaling";"PIP3 activates AKT signaling";"Costimulation by the CD28 family";"Regulation of actin dynamics for phagocytic cup formation";"Activated NTRK2 signals through RAS";"Spry regulation of FGF signaling";"GRB2 events in EGFR signaling";"PI-3K cascade:FGFR4";"Constitutive Signaling by Overexpressed ERBB2";"FLT3 Signaling";"Constitutive Signaling by EGFRvIII";"SHC-mediated cascade:FGFR2";"Signalling to RAS";"SHC-mediated cascade:FGFR4";"Role of LAT2/NTAL/LAB on calcium mobilization";"Signaling by SCF-KIT";"Clathrin-mediated endocytosis";"Negative regulation of FGFR2 signaling";"GRB2 events in ERBB2 signaling";"Negative regulation of FGFR1 signaling";"Signaling by FGFR4 in disease";"Interleukin receptor SHC signaling";"PI3K events in ERBB2 signaling";"Signaling by FGFR3 fusions in cancer";"SHC-mediated cascade:FGFR3";"FCERI mediated Ca+2 mobilization";"FCERI mediated MAPK activation";"Downstream signal transduction";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"Signaling by cytosolic FGFR1 fusion mutants";"MET receptor recycling";"Signaling by FGFR1 in disease";"Negative regulation of FGFR3 signaling";"Cargo recognition for clathrin-mediated endocytosis";"Erythropoietin activates RAS";"SHC-related events triggered by IGF1R";"Activated NTRK2 signals through FRS2 and FRS3";"Signal attenuation";"EGFR Transactivation by Gastrin";"PI3K Cascade";"RET signaling";"MET activates PI3K/AKT signaling";"Signaling by FGFR2 in disease";"DAP12 signaling";"Interleukin-15 signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"MET activates RAP1 and RAC1";"FRS-mediated FGFR2 signaling";"FRS-mediated FGFR1 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SOS-mediated signalling";"Signaling by FGFR3 point mutants in cancer";"FRS-mediated FGFR3 signaling";"STAT5 Activation";"MET activates PTPN11";"FRS-mediated FGFR4 signaling";"Tie2 Signaling";"PI-3K cascade:FGFR3";"Regulation of signaling by CBL";"CD28 dependent Vav1 pathway";"RHO GTPases Activate WASPs and WAVEs";"Signal regulatory protein family interactions";"Insulin receptor signalling cascade";"Regulation of KIT signaling"
XP_053964564.1	3	Reactome: R-HSA-191859;Reactome: R-HSA-6804760;Reactome: R-HSA-3214858	"snRNP Assembly";"Regulation of TP53 Activity through Methylation";"RMTs methylate histone arginines"
XP_053951286.1	5	Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-9615710;Reactome: R-HSA-917729	"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Budding and maturation of HIV virion";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)"
XP_053962237.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053966782.1	83	Reactome: R-HSA-2871809;Reactome: R-HSA-5654704;Reactome: R-HSA-8853334;Reactome: R-HSA-1963642;Reactome: R-HSA-912526;Reactome: R-HSA-5654726;Reactome: R-HSA-5655291;Reactome: R-HSA-1963640;Reactome: R-HSA-5654727;Reactome: R-HSA-8856828;Reactome: R-HSA-1433557;Reactome: R-HSA-2730905;Reactome: R-HSA-167044;Reactome: R-HSA-5654719;Reactome: R-HSA-5654699;Reactome: R-HSA-5637810;Reactome: R-HSA-9607240;Reactome: R-HSA-5654720;Reactome: R-HSA-9634285;Reactome: R-HSA-1295596;Reactome: R-HSA-179812;Reactome: R-HSA-9026519;Reactome: R-HSA-2029482;Reactome: R-HSA-1257604;Reactome: R-HSA-388841;Reactome: R-HSA-9034864;Reactome: R-HSA-1250196;Reactome: R-HSA-182971;Reactome: R-HSA-1236382;Reactome: R-HSA-9028335;Reactome: R-HSA-6807004;Reactome: R-HSA-180336;Reactome: R-HSA-5673001;Reactome: R-HSA-180292;Reactome: R-HSA-375165;Reactome: R-HSA-8851805;Reactome: R-HSA-5654688;Reactome: R-HSA-1250347;Reactome: R-HSA-9664565;Reactome: R-HSA-5654695;Reactome: R-HSA-354194;Reactome: R-HSA-8875360;Reactome: R-HSA-1433559;Reactome: R-HSA-74751;Reactome: R-HSA-5663213;Reactome: R-HSA-389359;Reactome: R-HSA-391160;Reactome: R-HSA-912631;Reactome: R-HSA-5654710;Reactome: R-HSA-210993;Reactome: R-HSA-5654712;Reactome: R-HSA-8865999;Reactome: R-HSA-9645135;Reactome: R-HSA-5654706;Reactome: R-HSA-8853338;Reactome: R-HSA-6811558;Reactome: R-HSA-112412;Reactome: R-HSA-5654693;Reactome: R-HSA-5654700;Reactome: R-HSA-8875555;Reactome: R-HSA-983695;Reactome: R-HSA-8983432;Reactome: R-HSA-2424491;Reactome: R-HSA-8851907;Reactome: R-HSA-5655253;Reactome: R-HSA-8853659;Reactome: R-HSA-109704;Reactome: R-HSA-2179392;Reactome: R-HSA-74749;Reactome: R-HSA-9028731;Reactome: R-HSA-2428933;Reactome: R-HSA-8856825;Reactome: R-HSA-9027284;Reactome: R-HSA-5654732;Reactome: R-HSA-5655302;Reactome: R-HSA-8875656;Reactome: R-HSA-1839117;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-512988;Reactome: R-HSA-2219530;Reactome: R-HSA-186763;Reactome: R-HSA-2871796	"FCERI mediated Ca+2 mobilization";"SHC-mediated cascade:FGFR3";"Signaling by FGFR3 fusions in cancer";"PI3K events in ERBB2 signaling";"Interleukin receptor SHC signaling";"Negative regulation of FGFR1 signaling";"Signaling by FGFR4 in disease";"GRB2 events in ERBB2 signaling";"Negative regulation of FGFR2 signaling";"Clathrin-mediated endocytosis";"Signaling by SCF-KIT";"Role of LAT2/NTAL/LAB on calcium mobilization";"Signalling to RAS";"SHC-mediated cascade:FGFR4";"SHC-mediated cascade:FGFR2";"Constitutive Signaling by EGFRvIII";"FLT3 Signaling";"PI-3K cascade:FGFR4";"Constitutive Signaling by Overexpressed ERBB2";"Spry regulation of FGF signaling";"GRB2 events in EGFR signaling";"Activated NTRK2 signals through RAS";"Regulation of actin dynamics for phagocytic cup formation";"PIP3 activates AKT signaling";"Costimulation by the CD28 family";"Activated NTRK3 signals through RAS";"SHC1 events in ERBB2 signaling";"EGFR downregulation";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Activated NTRK2 signals through PI3K";"Negative regulation of MET activity";"SHC1 events in EGFR signaling";"RAF/MAP kinase cascade";"GAB1 signalosome";"NCAM signaling for neurite out-growth";"MET activates RAS signaling";"SHC-mediated cascade:FGFR1";"SHC1 events in ERBB4 signaling";"Signaling by ERBB2 KD Mutants";"PI-3K cascade:FGFR2";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"InlB-mediated entry of Listeria monocytogenes into host cell";"Regulation of KIT signaling";"Insulin receptor signalling cascade";"RHO GTPases Activate WASPs and WAVEs";"CD28 dependent Vav1 pathway";"Signal regulatory protein family interactions";"Regulation of signaling by CBL";"PI-3K cascade:FGFR3";"Tie2 Signaling";"FRS-mediated FGFR4 signaling";"MET activates PTPN11";"STAT5 Activation";"FRS-mediated FGFR3 signaling";"Signaling by FGFR3 point mutants in cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SOS-mediated signalling";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR2 signaling";"MET activates RAP1 and RAC1";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Interleukin-15 signaling";"DAP12 signaling";"MET activates PI3K/AKT signaling";"Signaling by FGFR2 in disease";"RET signaling";"PI3K Cascade";"EGFR Transactivation by Gastrin";"Signal attenuation";"Activated NTRK2 signals through FRS2 and FRS3";"SHC-related events triggered by IGF1R";"Cargo recognition for clathrin-mediated endocytosis";"Erythropoietin activates RAS";"Negative regulation of FGFR3 signaling";"Signaling by FGFR1 in disease";"MET receptor recycling";"Signaling by cytosolic FGFR1 fusion mutants";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Downstream signal transduction";"FCERI mediated MAPK activation"
XP_053969430.1	7	KEGG: 00983+2.4.2.10;MetaCyc: PWY-7791;KEGG: 00240+4.1.1.23;MetaCyc: PWY-7790;Reactome: R-HSA-500753;MetaCyc: PWY-5686;KEGG: 00240+2.4.2.10	"Drug metabolism - other enzymes";"UMP biosynthesis III";"Pyrimidine metabolism";"UMP biosynthesis II";"Pyrimidine biosynthesis";"UMP biosynthesis I";"Pyrimidine metabolism"
XP_053962281.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053965305.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053949842.1	3	Reactome: R-HSA-1442490;Reactome: R-HSA-1474228;Reactome: R-HSA-1592389	"Collagen degradation";"Degradation of the extracellular matrix";"Activation of Matrix Metalloproteinases"
XP_053966009.1	56	Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-9604323;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-69481;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-382556;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-450408;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-4608870	"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Negative regulation of NOTCH4 signaling";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Hedgehog 'on' state";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Degradation of AXIN";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"G2/M Checkpoints";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"ABC-family proteins mediated transport";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"Asymmetric localization of PCP proteins"
XP_053958417.1	1	Reactome: R-HSA-1614635	"Sulfur amino acid metabolism"
XP_053965110.1	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
XP_053949507.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053950611.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_053948965.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053967203.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053963890.1	8	MetaCyc: PWY-6545;Reactome: R-HSA-499943;KEGG: 00240+2.7.4.9;MetaCyc: PWY-7198;MetaCyc: PWY-7197;MetaCyc: PWY-7187;MetaCyc: PWY-7184;MetaCyc: PWY-7210	"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP"
XP_053954893.1	5	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5675221;Reactome: R-HSA-112409;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"Negative regulation of MAPK pathway";"RAF-independent MAPK1/3 activation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053949664.1	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
XP_053952905.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053948216.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_053954597.1	11	KEGG: 00480+1.1.1.42;MetaCyc: PWY-6549;MetaCyc: PWY-6969;KEGG: 00020+1.1.1.42;KEGG: 00720+1.1.1.42;MetaCyc: PWY-7254;MetaCyc: PWY-7268;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-7124;MetaCyc: PWY-5913	"Glutathione metabolism";"L-glutamine biosynthesis III";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"TCA cycle VII (acetate-producers)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Ethylene biosynthesis V (engineered)";"Partial TCA cycle (obligate autotrophs)"
XP_053950891.1	4	MetaCyc: PWY-7375;Reactome: R-HSA-72086;Reactome: R-HSA-167160;Reactome: R-HSA-77075	"Mrna capping I";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE"
XP_053951119.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053969821.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053957560.1	25	Reactome: R-HSA-190840;Reactome: R-HSA-437239;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-1445148;Reactome: R-HSA-2132295;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434;Reactome: R-HSA-5626467;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-983189;Reactome: R-HSA-5663220;Reactome: R-HSA-6807878;Reactome: R-HSA-380270;Reactome: R-HSA-8852276;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-190861;Reactome: R-HSA-68877;Reactome: R-HSA-3371497	"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Recycling pathway of L1";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"MHC class II antigen presentation";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Cilium Assembly";"Aggrephagy";"Kinesins";"RHO GTPases Activate Formins";"COPI-mediated anterograde transport";"Recruitment of mitotic centrosome proteins and complexes";"The role of GTSE1 in G2/M progression after G2 checkpoint";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"Separation of Sister Chromatids";"Gap junction assembly";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
XP_053963257.1	6	KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;MetaCyc: PWY-7900;Reactome: R-HSA-189085;KEGG: 00500+2.4.1.18;MetaCyc: PWY-622	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Starch biosynthesis"
XP_053962725.1	3	Reactome: R-HSA-445989;Reactome: R-HSA-1810476;Reactome: R-HSA-933542	"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"RIP-mediated NFkB activation via ZBP1";"TRAF6 mediated NF-kB activation"
XP_053951112.1	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
XP_053957904.1	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
XP_053952154.1	5	KEGG: 00510+2.4.1.68;KEGG: 00513+2.4.1.68;MetaCyc: PWY-7426;Reactome: R-HSA-975578;KEGG: 00533+2.4.1.68	"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Reactions specific to the complex N-glycan synthesis pathway";"Glycosaminoglycan biosynthesis - keratan sulfate"
XP_053947221.1	8	Reactome: R-HSA-6798695;Reactome: R-HSA-74217;MetaCyc: PWY-6611;MetaCyc: PWY-6609;KEGG: 00230+3.5.4.4;MetaCyc: PWY-7179-1;Reactome: R-HSA-5683826;MetaCyc: PWY-7179	"Neutrophil degranulation";"Purine salvage";"Adenine and adenosine salvage V";"Adenine and adenosine salvage III";"Purine metabolism";"Purine deoxyribonucleosides degradation II";"Surfactant metabolism";"Purine deoxyribonucleosides degradation I"
XP_053964926.1	2	Reactome: R-HSA-110320;Reactome: R-HSA-983168	"Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053969840.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053955841.1	4	MetaCyc: PWY-6902;MetaCyc: PWY-7822;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14	"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism"
XP_053966337.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053954138.1	5	Reactome: R-HSA-9646399;Reactome: R-HSA-983168;Reactome: R-HSA-977225;Reactome: R-HSA-5689877;Reactome: R-HSA-5205685	"Aggrephagy";"Antigen processing: Ubiquitination & Proteasome degradation";"Amyloid fiber formation";"Josephin domain DUBs";"Pink/Parkin Mediated Mitophagy"
XP_053946000.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053954720.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053963723.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_053947948.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053958752.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_053963870.1	3	Reactome: R-HSA-2022854;Reactome: R-HSA-5173105;Reactome: R-HSA-5083627	"Keratan sulfate biosynthesis";"O-linked glycosylation";"Defective LARGE causes MDDGA6 and MDDGB6"
XP_053964775.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Neddylation"
XP_053957878.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_053960922.1	7	Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-5626467;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
XP_053958759.1	6	Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156827	"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_053960929.1	7	Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation"
XP_053954577.1	24	Reactome: R-HSA-5607764;Reactome: R-HSA-444257;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5218921;Reactome: R-HSA-9634635;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-2730905;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-392451;Reactome: R-HSA-1257604;KEGG: 04926+2.7.11.1;Reactome: R-HSA-354192;Reactome: R-HSA-5674400;KEGG: 04150+2.7.11.1;Reactome: R-HSA-165158;Reactome: R-HSA-5625740;KEGG: 05165+2.7.11.1;Reactome: R-HSA-389357;KEGG: 05163+2.7.11.1;Reactome: R-HSA-202424;Reactome: R-HSA-114604;Reactome: R-HSA-2871837	"CLEC7A (Dectin-1) signaling";"RSK activation";"PI3K-Akt signaling pathway";"VEGFR2 mediated cell proliferation";"Estrogen-stimulated signaling through PRKCZ";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"Role of LAT2/NTAL/LAB on calcium mobilization";"Thermogenesis";"Human immunodeficiency virus 1 infection";"G beta:gamma signalling through PI3Kgamma";"PIP3 activates AKT signaling";"Relaxin signaling pathway";"Integrin signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"mTOR signaling pathway";"Activation of AKT2";"RHO GTPases activate PKNs";"Human papillomavirus infection";"CD28 dependent PI3K/Akt signaling";"Human cytomegalovirus infection";"Downstream TCR signaling";"GPVI-mediated activation cascade";"FCERI mediated NF-kB activation"
XP_053961460.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053964451.1	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
XP_053966469.1	7	Reactome: R-HSA-3000171;Reactome: R-HSA-5083628;Reactome: R-HSA-5083629;Reactome: R-HSA-3000178;Reactome: R-HSA-9010553;Reactome: R-HSA-5173105;Reactome: R-HSA-5083633	"Non-integrin membrane-ECM interactions";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"ECM proteoglycans";"Regulation of expression of SLITs and ROBOs";"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1"
XP_053955789.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053947940.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053956895.1	4	Reactome: R-HSA-4549349;Reactome: R-HSA-446193;KEGG: 00513+2.4.1.257+2.4.1.132;KEGG: 00510+2.4.1.257+2.4.1.132	"Defective ALG2 causes ALG2-CDG (CDG-1i)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
XP_053947884.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053957204.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053946788.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053957658.1	14	Reactome: R-HSA-69273;Reactome: R-HSA-3769402;Reactome: R-HSA-9648025;Reactome: R-HSA-9634638;Reactome: R-HSA-165054;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-2173788;Reactome: R-HSA-5663220;Reactome: R-HSA-450520;Reactome: R-HSA-5687128;Reactome: R-HSA-168333;Reactome: R-HSA-141444	"Cyclin A/B1/B2 associated events during G2/M transition";"Deactivation of the beta-catenin transactivating complex";"EML4 and NUDC in mitotic spindle formation";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Rev-mediated nuclear export of HIV RNA";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Downregulation of TGF-beta receptor signaling";"RHO GTPases Activate Formins";"HuR (ELAVL1) binds and stabilizes mRNA";"MAPK6/MAPK4 signaling";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_053964226.1	27	Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-168333	"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"NEP/NS2 Interacts with the Cellular Export Machinery"
XP_053961245.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-110320	"Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH"
XP_053946147.1	5	Reactome: R-HSA-3769402;Reactome: R-HSA-8936459;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-3214841	"Deactivation of the beta-catenin transactivating complex";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines"
XP_053954653.1	2	Reactome: R-HSA-1483152;Reactome: R-HSA-1483115	"Hydrolysis of LPE";"Hydrolysis of LPC"
XP_053945152.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053954563.1	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
XP_053946829.1	6	Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-450513	"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_053963904.1	17	Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-176407;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-174184;Reactome: R-HSA-8951664;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-174084;Reactome: R-HSA-174048;Reactome: R-HSA-176408;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-2467813;Reactome: R-HSA-8853884;Reactome: R-HSA-141430	"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neddylation";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Separation of Sister Chromatids";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex"
XP_053947248.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053962276.1	5	KEGG: 00620+4.1.1.32;KEGG: 00020+4.1.1.32;Reactome: R-HSA-70263;MetaCyc: PWY-7383;KEGG: 00010+4.1.1.32	"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis / Gluconeogenesis"
XP_053960385.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053957326.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053954867.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053946822.1	4	MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174;Reactome: R-HSA-1237112	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Methionine salvage pathway"
XP_053947465.1	6	MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism"
XP_053958719.1	12	Reactome: R-HSA-2894862;Reactome: R-HSA-977225;Reactome: R-HSA-2644606;Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096;Reactome: R-HSA-193692;Reactome: R-HSA-9017802	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Amyloid fiber formation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Regulated proteolysis of p75NTR";"Noncanonical activation of NOTCH3"
XP_053952778.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053957610.1	1	KEGG: 00240+3.1.3.89	"Pyrimidine metabolism"
XP_053952040.1	5	Reactome: R-HSA-186763;Reactome: R-HSA-5218921;Reactome: R-HSA-8849471;Reactome: R-HSA-5658442;Reactome: R-HSA-3928662	"Downstream signal transduction";"VEGFR2 mediated cell proliferation";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases";"Regulation of RAS by GAPs";"EPHB-mediated forward signaling"
XP_053947456.1	24	Reactome: R-HSA-983189;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-8955332;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-1445148;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-380320;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-190861	"Kinesins";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic";"HCMV Early Events";"RHO GTPases activate IQGAPs";"Carboxyterminal post-translational modifications of tubulin";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of NuMA to mitotic centrosomes";"Aggrephagy";"Cilium Assembly";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Gap junction assembly"
XP_053960744.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053960229.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_053969848.1	4	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.18;Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
XP_053963133.1	10	MetaCyc: PWY-6372;Reactome: R-HSA-1855191;Reactome: R-HSA-1855167;KEGG: 04070+2.7.1.158;MetaCyc: PWY-4661;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6361;MetaCyc: PWY-6554;MetaCyc: PWY-6362;MetaCyc: PWY-6369	"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of IPs in the nucleus";"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol diphosphates biosynthesis"
XP_053958828.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053952184.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053959590.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053951173.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053956861.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053957931.1	58	KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;Reactome: R-HSA-77346;MetaCyc: PWY-7007;MetaCyc: PWY-7606;KEGG: 00280+4.2.1.17;Reactome: R-HSA-77285;MetaCyc: PWY-6883;Reactome: R-HSA-77310;KEGG: 00903+4.2.1.17;Reactome: R-HSA-77348;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;MetaCyc: PWY-6435;KEGG: 00930+4.2.1.17+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.211;MetaCyc: PWY-5789;MetaCyc: PWY-7726;MetaCyc: PWY-7216;MetaCyc: PWY-5138;MetaCyc: PWY-6944;KEGG: 00071+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;KEGG: 00623+1.1.1.35;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7656;Reactome: R-HSA-77305;KEGG: 00310+4.2.1.17;KEGG: 00930+4.2.1.17;KEGG: 00380+4.2.1.17;MetaCyc: PWY-7094;MetaCyc: PWY-7654;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00410+4.2.1.17;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;MetaCyc: PWY-6863;KEGG: 00592+4.2.1.17;KEGG: 00062+4.2.1.17+1.1.1.211;MetaCyc: PWY-6945;MetaCyc: PWY-1361;Reactome: R-HSA-77350;Reactome: R-HSA-1482798;MetaCyc: PWY-6583;KEGG: 00281+4.2.1.17;MetaCyc: PWY-7401;KEGG: 00650+4.2.1.17;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00362+4.2.1.17;MetaCyc: PWY-7779;Reactome: R-HSA-77288;KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00720+4.2.1.17;MetaCyc: PWY-5136;MetaCyc: PWY-7778;MetaCyc: PWY-5109;KEGG: 00281+4.2.1.17+1.1.1.35	"Benzoate degradation";"Propanoate metabolism";"Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Valine, leucine and isoleucine degradation";"Beta oxidation of myristoyl-CoA to lauroyl-CoA";"Pyruvate fermentation to butanol II (engineered)";"Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA";"Limonene and pinene degradation";"Beta oxidation of octanoyl-CoA to hexanoyl-CoA";"Valine, leucine and isoleucine degradation";"Fatty acid elongation";"Glutaryl-coa degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Caprolactam degradation";"Fatty acid degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Androstenedione degradation";"Fatty acid degradation";"Phenylalanine metabolism";"Toluene degradation";"Aminobenzoate degradation";"Spodoptera littoralis pheromone biosynthesis";"Beta oxidation of palmitoyl-CoA to myristoyl-CoA";"Lysine degradation";"Caprolactam degradation";"Tryptophan metabolism";"Fatty acid salvage";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Butanoate metabolism";"beta-Alanine metabolism";"Lysine degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Pyruvate fermentation to hexanol (engineered)";"alpha-Linolenic acid metabolism";"Fatty acid elongation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Benzoyl-coa degradation I (aerobic)";"Beta oxidation of hexanoyl-CoA to butanoyl-CoA";"Acyl chain remodeling of CL";"Pyruvate fermentation to butanol I";"Geraniol degradation";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Butanoate metabolism";"Tryptophan metabolism";"Benzoate degradation";"Methyl tert-butyl ether degradation";"mitochondrial fatty acid beta-oxidation of unsaturated fatty acids";"Carbon fixation pathways in prokaryotes";"Carbon fixation pathways in prokaryotes";"Fatty acid beta-oxidation II (plant peroxisome)";"2-methylpropene degradation";"Fermentation to 2-methylbutanoate";"Geraniol degradation"
XP_053950816.1	13	Reactome: R-HSA-2871809;MetaCyc: PWY-6351;Reactome: R-HSA-202433;Reactome: R-HSA-2029485;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;Reactome: R-HSA-9027277;Reactome: R-HSA-2424491;Reactome: R-HSA-2871796;MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11;MetaCyc: PWY-8052	"FCERI mediated Ca+2 mobilization";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Generation of second messenger molecules";"Role of phospholipids in phagocytosis";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"Erythropoietin activates Phospholipase C gamma (PLCG)";"DAP12 signaling";"FCERI mediated MAPK activation";"Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism";"2-arachidonoylglycerol biosynthesis"
XP_053945173.1	3	MetaCyc: PWY-5987;MetaCyc: PWY-5996;Reactome: R-HSA-75105	"Sorgoleone biosynthesis";"Oleate biosynthesis II (animals and fungi)";"Fatty acyl-CoA biosynthesis"
XP_053946718.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053963269.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053950575.1	3	KEGG: 00330+1.14.11.2;MetaCyc: PWY-7894;Reactome: R-HSA-1650814	"Arginine and proline metabolism";"Procollagen hydroxylation and glycosylation";"Collagen biosynthesis and modifying enzymes"
XP_053958002.1	3	Reactome: R-HSA-983168;Reactome: R-HSA-390471;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Association of TriC/CCT with target proteins during biosynthesis";"Neddylation"
XP_053963287.1	2	Reactome: R-HSA-1566948;Reactome: R-HSA-2243919	"Elastic fibre formation";"Crosslinking of collagen fibrils"
XP_053947491.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_053962192.1	11	MetaCyc: PWY-7185;KEGG: 00230+3.1.3.5;MetaCyc: PWY-6607;MetaCyc: PWY-6606;MetaCyc: PWY-7821;MetaCyc: PWY-6596;KEGG: 00240+3.1.3.5;KEGG: 00760+3.1.3.5;MetaCyc: PWY-5695;MetaCyc: PWY-5381;MetaCyc: PWY-6608	"UTP and CTP dephosphorylation I";"Purine metabolism";"Guanosine nucleotides degradation I";"Guanosine nucleotides degradation II";"Tunicamycin biosynthesis";"Adenosine nucleotides degradation I";"Pyrimidine metabolism";"Nicotinate and nicotinamide metabolism";"Inosine 5'-phosphate degradation";"Pyridine nucleotide cycling (plants)";"Guanosine nucleotides degradation III"
XP_053948271.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053952622.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053962199.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_053963688.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053955601.1	1	Reactome: R-HSA-380972	"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_053956832.1	4	KEGG: 00380+1.14.16.4;MetaCyc: PWY-6030;Reactome: R-HSA-209931;KEGG: 00790+1.14.16.4	"Tryptophan metabolism";"Serotonin and melatonin biosynthesis";"Serotonin and melatonin biosynthesis";"Folate biosynthesis"
XP_053957969.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_053946174.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053959176.1	12	MetaCyc: PWY-5278;MetaCyc: PWY-5340;KEGG: 00230+2.7.7.4;MetaCyc: PWY-6683;KEGG: 00920+2.7.1.25;Reactome: R-HSA-2408550;KEGG: 00261+2.7.7.4;KEGG: 00230+2.7.1.25;Reactome: R-HSA-174362;MetaCyc: PWY-6932;KEGG: 00920+2.7.7.4;KEGG: 00450+2.7.7.4	"Sulfite oxidation III";"Sulfate activation for sulfonation";"Purine metabolism";"Assimilatory sulfate reduction III";"Sulfur metabolism";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Monobactam biosynthesis";"Purine metabolism";"Transport and synthesis of PAPS";"Selenate reduction";"Sulfur metabolism";"Selenocompound metabolism"
XP_053947397.1	4	MetaCyc: PWY-6483;MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662	"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism";"Glycosphingolipid metabolism"
XP_053957688.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053965586.1	6	MetaCyc: PWY-622;KEGG: 00500+2.4.1.18;Reactome: R-HSA-3322077;MetaCyc: PWY-7900;Reactome: R-HSA-3878781;MetaCyc: PWY-5067	"Starch biosynthesis";"Starch and sucrose metabolism";"Glycogen synthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen storage disease type IV (GBE1)";"Glycogen biosynthesis II (from UDP-D-Glucose)"
XP_053964387.1	7	KEGG: 00020+2.3.1.61;Reactome: R-HSA-71403;Reactome: R-HSA-71064;KEGG: 00310+2.3.1.61;KEGG: 00380+2.3.1.61;MetaCyc: PWY-5084;Reactome: R-HSA-389661	"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Lysine catabolism";"Lysine degradation";"Tryptophan metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation"
XP_053955064.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_053951167.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053963969.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_053968615.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053963987.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053963962.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053949359.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053959598.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053964496.1	17	MetaCyc: PWY-6679;MetaCyc: PWY-6722;KEGG: 00061+6.4.1.2;KEGG: 00620+6.4.1.2;MetaCyc: PWY-5743;Reactome: R-HSA-200425;MetaCyc: PWY-5789;KEGG: 00640+6.4.1.2;KEGG: 00254+6.4.1.2;Reactome: R-HSA-196780;KEGG: 00720+6.4.1.2;MetaCyc: PWY-5744;Reactome: R-HSA-163765;MetaCyc: PWY-4381;Reactome: R-HSA-3371599;MetaCyc: PWY-5966-1;Reactome: R-HSA-2426168	"Jadomycin biosynthesis";"Candicidin biosynthesis";"Fatty acid biosynthesis";"Pyruvate metabolism";"3-hydroxypropanoate cycle";"Carnitine metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Propanoate metabolism";"Aflatoxin biosynthesis";"Biotin transport and metabolism";"Carbon fixation pathways in prokaryotes";"Glyoxylate assimilation";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (bacteria and plants)";"Defective HLCS causes multiple carboxylase deficiency";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Activation of gene expression by SREBF (SREBP)"
XP_053967146.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_053954859.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_053970020.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053965756.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053955604.1	11	Reactome: R-HSA-8939236;Reactome: R-HSA-5663213;Reactome: R-HSA-8940973;Reactome: R-HSA-983231;Reactome: R-HSA-2029482;Reactome: R-HSA-525793;Reactome: R-HSA-428890;Reactome: R-HSA-69231;Reactome: R-HSA-5685938;Reactome: R-HSA-5693565;KEGG: 04660+2.7.10.2	"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RHO GTPases Activate WASPs and WAVEs";"RUNX2 regulates osteoblast differentiation";"Factors involved in megakaryocyte development and platelet production";"Regulation of actin dynamics for phagocytic cup formation";"Myogenesis";"Role of ABL in ROBO-SLIT signaling";"Cyclin D associated events in G1";"HDR through Single Strand Annealing (SSA)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"T cell receptor signaling pathway"
XP_053946171.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053952137.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053962318.1	1	Reactome: R-HSA-1483255	"PI Metabolism"
XP_053966593.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053946259.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_053953955.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
XP_053965765.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_053947494.1	10	MetaCyc: PWY-6352;KEGG: 05163+2.7.1.153;KEGG: 05170+2.7.1.153;KEGG: 04150+2.7.1.153;Reactome: R-HSA-9027276;KEGG: 04070+2.7.1.153;KEGG: 00562+2.7.1.153;KEGG: 04151+2.7.1.153;Reactome: R-HSA-1660499;KEGG: 05165+2.7.1.153	"3-phosphoinositide biosynthesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"PI3K-Akt signaling pathway";"Synthesis of PIPs at the plasma membrane";"Human papillomavirus infection"
XP_053957827.1	33	MetaCyc: PWY-5057;MetaCyc: PWY-5486;KEGG: 00626+1.1.1.1;MetaCyc: PWY-7396;MetaCyc: PWY-6871;MetaCyc: PWY-6313;KEGG: 00592+1.1.1.1;MetaCyc: PWY-6802;KEGG: 00980+1.1.1.1;MetaCyc: PWY-5480;KEGG: 00680+1.1.1.284;MetaCyc: PWY-7111;KEGG: 00982+1.1.1.1;MetaCyc: PWY-1801;MetaCyc: PWY-5076;MetaCyc: PWY-5079;MetaCyc: PWY-5751;MetaCyc: PWY-6333;MetaCyc: PWY-7118;MetaCyc: PWY-5078;KEGG: 00010+1.1.1.1;KEGG: 00071+1.1.1.1;KEGG: 00260+1.1.1.1;KEGG: 00350+1.1.1.1;MetaCyc: PWY-7798;KEGG: 00830+1.1.1.1;MetaCyc: PWY-3162;MetaCyc: PWY-6587;KEGG: 00625+1.1.1.1;MetaCyc: PWY-7013;MetaCyc: PWY-6342;MetaCyc: PWY-5082;Reactome: R-HSA-71384	"L-valine degradation II";"Pyruvate fermentation to ethanol II";"Naphthalene degradation";"Butanol and isobutanol biosynthesis (engineered)";"3-methylbutanol biosynthesis (engineered)";"Serotonin degradation";"alpha-Linolenic acid metabolism";"Salidroside biosynthesis";"Metabolism of xenobiotics by cytochrome P450";"Pyruvate fermentation to ethanol I";"Methane metabolism";"Pyruvate fermentation to isobutanol (engineered)";"Drug metabolism - cytochrome P450";"Formaldehyde oxidation II (glutathione-dependent)";"L-leucine degradation III";"L-phenylalanine degradation III";"Phenylethanol biosynthesis";"Acetaldehyde biosynthesis I";"Chitin degradation to ethanol";"L-isoleucine degradation II";"Glycolysis / Gluconeogenesis";"Fatty acid degradation";"Glycine, serine and threonine metabolism";"Tyrosine metabolism";"Protein S-nitrosylation and denitrosylation";"Retinol metabolism";"L-tryptophan degradation V (side chain pathway)";"Pyruvate fermentation to ethanol III";"Chloroalkane and chloroalkene degradation";"(S)-propane-1,2-diol degradation";"Noradrenaline and adrenaline degradation";"L-methionine degradation III";"Ethanol oxidation"
XP_053952860.1	7	MetaCyc: PWY-7445;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5469;MetaCyc: PWY-7214;MetaCyc: PWY-6824;MetaCyc: PWY-5466	"Luteolin triglucuronide degradation";"Betanidin degradation";"Phenylpropanoid biosynthesis";"Sesamin biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Justicidin B biosynthesis";"Matairesinol biosynthesis"
XP_053946588.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053955258.1	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_053946919.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053954108.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053958519.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053957149.1	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.1	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053955657.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053964865.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053952181.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053957768.1	13	Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956	"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_053952213.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions"
XP_053950387.1	2	MetaCyc: PWY-6019;KEGG: 00240+4.2.1.70	"Pseudouridine degradation";"Pyrimidine metabolism"
XP_053956864.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053948390.1	6	MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism"
XP_053963142.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053949675.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053952570.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053955039.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053954100.1	1	Reactome: R-HSA-203754	"NOSIP mediated eNOS trafficking"
XP_053946212.1	2	Reactome: R-HSA-425393;Reactome: R-HSA-5223345	"Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events"
XP_053953255.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053958687.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_053958662.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
XP_053958095.1	1	Reactome: R-HSA-140342	"Apoptosis induced DNA fragmentation"
XP_053945621.1	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
XP_053957760.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053970158.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053969172.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053962105.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_053949815.1	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
XP_053956574.1	13	Reactome: R-HSA-196836;MetaCyc: PWY-7112;KEGG: 00053+1.8.5.1;MetaCyc: PWY-6370;KEGG: 00982+2.5.1.18;KEGG: 00980+2.5.1.18;Reactome: R-HSA-156590;MetaCyc: PWY-7533;KEGG: 00480+2.5.1.18+1.8.5.1;KEGG: 00983+2.5.1.18;MetaCyc: PWY-4061;MetaCyc: PWY-2261;MetaCyc: PWY-6842	"Vitamin C (ascorbate) metabolism";"4-hydroxy-2-nonenal detoxification";"Ascorbate and aldarate metabolism";"Ascorbate recycling (cytosolic)";"Drug metabolism - cytochrome P450";"Metabolism of xenobiotics by cytochrome P450";"Glutathione conjugation";"Gliotoxin biosynthesis";"Glutathione metabolism";"Drug metabolism - other enzymes";"Glutathione-mediated detoxification I";"Ascorbate glutathione cycle";"Glutathione-mediated detoxification II"
XP_053965313.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053964816.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-9033500	"Peroxisomal protein import";"TYSND1 cleaves peroxisomal proteins"
XP_053967966.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053952868.1	10	Reactome: R-HSA-5609977;MetaCyc: PWY-6397;MetaCyc: PWY-7328;Reactome: R-HSA-70370;MetaCyc: PWY-6317;KEGG: 00520+5.1.3.2;KEGG: 00052+5.1.3.2;MetaCyc: PWY-3821;MetaCyc: PWY-6527;MetaCyc: PWY-7344	"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Galactose catabolism";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"D-galactose detoxification";"Stachyose degradation";"UDP-alpha-D-galactose biosynthesis"
XP_053948022.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053967955.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053962626.1	13	KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;KEGG: 00603+3.2.1.52;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;KEGG: 00511+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52	"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Chitin degradation III (Serratia)";"CS/DS degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Other glycan degradation";"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
XP_053963827.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053955910.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053948029.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053956547.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_053954744.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429958	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease"
XP_053960130.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053955631.1	14	Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7619;MetaCyc: PWY-7724;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-5080	"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Sciadonate biosynthesis";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I"
XP_053964454.1	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
XP_053946558.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053955288.1	5	KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2	"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism"
XP_053962438.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053951029.1	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
XP_053954222.1	2	Reactome: R-HSA-427413;Reactome: R-HSA-3214847	"NoRC negatively regulates rRNA expression";"HATs acetylate histones"
XP_053956771.1	3	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
XP_053958910.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053963201.1	5	KEGG: 00515+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109	"Mannose type O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis"
XP_053958061.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053946973.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053965786.1	15	Reactome: R-HSA-8934593;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-8986944;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459;Reactome: R-HSA-9029569;Reactome: R-HSA-4086398;Reactome: R-HSA-1912408;Reactome: R-HSA-8943723;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692;Reactome: R-HSA-2559585	"Regulation of RUNX1 Expression and Activity";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by MECP2";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Ca2+ pathway";"Pre-NOTCH Transcription and Translation";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity";"Oncogene Induced Senescence"
XP_053961156.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053966384.1	1	MetaCyc: PWY-7533	"Gliotoxin biosynthesis"
XP_053958250.1	11	KEGG: 00561+3.1.3.4;Reactome: R-HSA-2029485;MetaCyc: PWY-8052;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-8053;KEGG: 00565+3.1.3.4;MetaCyc: PWY-6453;KEGG: 00564+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4	"Glycerolipid metabolism";"Role of phospholipids in phagocytosis";"2-arachidonoylglycerol biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Anandamide biosynthesis II";"Ether lipid metabolism";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Sphingolipid metabolism"
XP_053964407.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_053947703.1	3	MetaCyc: PWY-5698;KEGG: 00230+3.5.2.5;MetaCyc: PWY-5697	"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Purine metabolism";"Allantoin degradation to ureidoglycolate I (urea producing)"
XP_053958039.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053950045.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053951974.1	1	Reactome: R-HSA-71262	"Carnitine synthesis"
XP_053947742.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053967285.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_053952983.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_053947168.1	9	MetaCyc: PWY-241;Reactome: R-HSA-1475029;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5789	"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle"
XP_053967322.1	4	Reactome: R-HSA-2470946;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052	"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion"
XP_053965383.1	3	Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053949885.1	6	MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1	"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism"
XP_053958218.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-5663220	"Signaling by ROBO receptors";"RHO GTPases Activate Formins"
XP_053955662.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053952279.1	4	MetaCyc: PWY-5642;KEGG: 00640+1.2.1.27;Reactome: R-HSA-70895;KEGG: 00280+1.2.1.27	"2,4-dinitrotoluene degradation";"Propanoate metabolism";"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation"
XP_053960577.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053946518.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053947533.1	5	Reactome: R-HSA-9649948;Reactome: R-HSA-5675221;Reactome: R-HSA-6802955;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000	"Signaling downstream of RAS mutants";"Negative regulation of MAPK pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by moderate kinase activity BRAF mutants";"RAF activation"
XP_053946982.1	4	Reactome: R-HSA-71240;Reactome: R-HSA-210991;Reactome: R-HSA-5660862;Reactome: R-HSA-352230	"Tryptophan catabolism";"Basigin interactions";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)";"Amino acid transport across the plasma membrane"
XP_053960741.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053955988.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053950775.1	12	Reactome: R-HSA-5673001;KEGG: 00230+2.7.4.8;Reactome: R-HSA-9620244;Reactome: R-HSA-399719;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-8849932;MetaCyc: PWY-7221;Reactome: R-HSA-438066;Reactome: R-HSA-451308;Reactome: R-HSA-447038;Reactome: R-HSA-9609736	"RAF/MAP kinase cascade";"Purine metabolism";"Long-term potentiation";"Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Synaptic adhesion-like molecules";"Guanosine ribonucleotides de novo biosynthesis";"Unblocking of NMDA receptors, glutamate binding and activation";"Activation of Ca-permeable Kainate Receptor";"NrCAM interactions";"Assembly and cell surface presentation of NMDA receptors"
XP_053947079.1	1	Reactome: R-HSA-446210	"Synthesis of UDP-N-acetyl-glucosamine"
XP_053961116.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053952024.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053946273.1	5	KEGG: 00250+2.6.1.16;KEGG: 00520+2.6.1.16;MetaCyc: PWY-6749;Reactome: R-HSA-446210;MetaCyc: PWY-8013	"Alanine, aspartate and glutamate metabolism";"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I";"Synthesis of UDP-N-acetyl-glucosamine";"UDP-N-acetyl-D-galactosamine biosynthesis III"
XP_053958210.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-5663220	"Signaling by ROBO receptors";"RHO GTPases Activate Formins"
XP_053958950.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053951274.1	3	KEGG: 00970+6.1.1.5;Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
XP_053956041.1	16	Reactome: R-HSA-6811558;Reactome: R-HSA-8863795;Reactome: R-HSA-5673001;Reactome: R-HSA-2219530;Reactome: R-HSA-9664565;Reactome: R-HSA-1250347;Reactome: R-HSA-1251985;Reactome: R-HSA-6785631;Reactome: R-HSA-1236394;Reactome: R-HSA-1227986;Reactome: R-HSA-1257604;Reactome: R-HSA-1250196;Reactome: R-HSA-1963642;Reactome: R-HSA-1963640;Reactome: R-HSA-1250342;Reactome: R-HSA-8847993	"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downregulation of ERBB2 signaling";"RAF/MAP kinase cascade";"Constitutive Signaling by Aberrant PI3K in Cancer";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB4 signaling";"Nuclear signaling by ERBB4";"ERBB2 Regulates Cell Motility";"Signaling by ERBB4";"Signaling by ERBB2";"PIP3 activates AKT signaling";"SHC1 events in ERBB2 signaling";"PI3K events in ERBB2 signaling";"GRB2 events in ERBB2 signaling";"PI3K events in ERBB4 signaling";"ERBB2 Activates PTK6 Signaling"
XP_053944995.1	1	Reactome: R-HSA-6783984	"Glycine degradation"
XP_053970063.1	7	MetaCyc: PWY-5469;MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-7445;MetaCyc: PWY-6824	"Sesamin biosynthesis";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Betanidin degradation";"Phenylpropanoid biosynthesis";"Luteolin triglucuronide degradation";"Justicidin B biosynthesis"
XP_053950317.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053958604.1	2	Reactome: R-HSA-204005;Reactome: R-HSA-5694530	"COPII-mediated vesicle transport";"Cargo concentration in the ER"
XP_053950926.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053965433.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053956020.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_053952972.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053958567.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053947881.1	2	KEGG: 00062+3.1.2.22;Reactome: R-HSA-75105	"Fatty acid elongation";"Fatty acyl-CoA biosynthesis"
XP_053967090.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_053953098.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053958589.1	2	Reactome: R-HSA-6803157;Reactome: R-HSA-6798695	"Antimicrobial peptides";"Neutrophil degranulation"
XP_053958918.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_053964394.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053949889.1	6	MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1;MetaCyc: PWY-7761;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807	"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
XP_053950386.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053964978.1	10	Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-9022699;Reactome: R-HSA-9022538;Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-9022692;Reactome: R-HSA-3899300	"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of MECP2 expression and activity";"SUMOylation of transcription cofactors"
XP_053956395.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053955665.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053968014.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_053967289.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053966306.1	10	Reactome: R-HSA-9013508;Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-210744;Reactome: R-HSA-2894862;Reactome: R-HSA-2197563;Reactome: R-HSA-9013695;Reactome: R-HSA-1912408;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606	"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 intracellular domain regulates transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_053950049.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-2894862	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053955656.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053949130.1	9	Reactome: R-HSA-416482;Reactome: R-HSA-2029482;Reactome: R-HSA-2871796;Reactome: R-HSA-114604;Reactome: R-HSA-194840;Reactome: R-HSA-5218920;Reactome: R-HSA-2871809;Reactome: R-HSA-193648;Reactome: R-HSA-4420097	"G alpha (12/13) signalling events";"Regulation of actin dynamics for phagocytic cup formation";"FCERI mediated MAPK activation";"GPVI-mediated activation cascade";"Rho GTPase cycle";"VEGFR2 mediated vascular permeability";"FCERI mediated Ca+2 mobilization";"NRAGE signals death through JNK";"VEGFA-VEGFR2 Pathway"
XP_053950783.1	8	KEGG: 00230+2.7.4.8;Reactome: R-HSA-9620244;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-9609736;Reactome: R-HSA-438066;MetaCyc: PWY-7221;Reactome: R-HSA-5673001	"Purine metabolism";"Long-term potentiation";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Assembly and cell surface presentation of NMDA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"Guanosine ribonucleotides de novo biosynthesis";"RAF/MAP kinase cascade"
XP_053961070.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053946322.1	11	Reactome: R-HSA-5685942;Reactome: R-HSA-6782210;Reactome: R-HSA-68952;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-174430;Reactome: R-HSA-6782135;Reactome: R-HSA-68962;Reactome: R-HSA-5696400	"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"DNA replication initiation";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Telomere C-strand synthesis initiation";"Dual incision in TC-NER";"Activation of the pre-replicative complex";"Dual Incision in GG-NER"
XP_053957826.1	13	Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053951458.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053966896.1	6	Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-5620922;Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389957	"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"BBSome-mediated cargo-targeting to cilium";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053956805.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_053958474.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_053962928.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053961162.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053952323.1	7	Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-1655829;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-203927	"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"MicroRNA (miRNA) biogenesis"
XP_053958585.1	3	Reactome: R-HSA-8963684;KEGG: 00350+1.13.11.5;KEGG: 00643+1.13.11.5	"Tyrosine catabolism";"Tyrosine metabolism";"Styrene degradation"
XP_053954461.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053967660.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-936837	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Ion transport by P-type ATPases"
XP_053968787.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_053968762.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_053962627.1	13	MetaCyc: PWY-7822;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;KEGG: 00513+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7883;Reactome: R-HSA-1660662;KEGG: 00603+3.2.1.52;Reactome: R-HSA-2024101	"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Various types of N-glycan biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)";"Other glycan degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"CS/DS degradation"
XP_053952197.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions"
XP_053949741.1	3	KEGG: 00790+2.8.1.9;MetaCyc: PWY-5963;Reactome: R-HSA-947581	"Folate biosynthesis";"Thio-molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
XP_053944992.1	1	Reactome: R-HSA-6783984	"Glycine degradation"
XP_053949873.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053947434.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053949577.1	3	Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-430039	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease"
XP_053950436.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053964817.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-9033500	"Peroxisomal protein import";"TYSND1 cleaves peroxisomal proteins"
XP_053951418.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053953325.1	3	Reactome: R-HSA-5358493;MetaCyc: PWY-7546;MetaCyc: PWY-6482	"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)"
XP_053946090.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053966924.1	2	Reactome: R-HSA-426117;Reactome: R-HSA-5619039	"Cation-coupled Chloride cotransporters";"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)"
XP_053953267.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053968007.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053949138.1	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
XP_053950779.1	12	MetaCyc: PWY-7221;Reactome: R-HSA-438066;Reactome: R-HSA-451308;Reactome: R-HSA-447038;Reactome: R-HSA-8849932;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;KEGG: 00230+2.7.4.8;Reactome: R-HSA-9620244;Reactome: R-HSA-399719	"Guanosine ribonucleotides de novo biosynthesis";"Unblocking of NMDA receptors, glutamate binding and activation";"Activation of Ca-permeable Kainate Receptor";"NrCAM interactions";"Synaptic adhesion-like molecules";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Purine metabolism";"Long-term potentiation";"Trafficking of AMPA receptors"
XP_053955515.1	8	Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-180024;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-381676;Reactome: R-HSA-163615;Reactome: R-HSA-983231	"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"DARPP-32 events";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"PKA activation";"Factors involved in megakaryocyte development and platelet production"
XP_053957994.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053949613.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053948330.1	7	Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389957;Reactome: R-HSA-5620922;Reactome: R-HSA-6798695;Reactome: R-HSA-390471;Reactome: R-HSA-389960	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Neutrophil degranulation";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC"
XP_053964862.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053964887.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053954495.1	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
XP_053957424.1	8	Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-165054;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-141444	"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_053964869.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053967588.1	2	Reactome: R-HSA-3214815;Reactome: R-HSA-427413	"HDACs deacetylate histones";"NoRC negatively regulates rRNA expression"
XP_053964583.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053964406.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_053959508.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053949859.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_053966053.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053965731.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053964644.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053957145.1	4	KEGG: 00970+6.1.1.17;MetaCyc: PWY-5188;KEGG: 00860+6.1.1.17;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"Mitochondrial tRNA aminoacylation"
XP_053950227.1	2	Reactome: R-HSA-114608;KEGG: 00970+6.1.1.3	"Platelet degranulation";"Aminoacyl-tRNA biosynthesis"
XP_053965787.1	15	Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459;Reactome: R-HSA-8934593;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-4086398;Reactome: R-HSA-1912408	"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX1 Expression and Activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Ca2+ pathway";"Pre-NOTCH Transcription and Translation"
XP_053961157.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053946255.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_053956546.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_053954352.1	3	KEGG: 00051+2.7.1.3;Reactome: R-HSA-5657562;Reactome: R-HSA-70350	"Fructose and mannose metabolism";"Essential fructosuria";"Fructose catabolism"
XP_053958341.1	7	MetaCyc: PWY-5484;KEGG: 00010+3.1.3.11;KEGG: 00051+3.1.3.11;Reactome: R-HSA-70263;KEGG: 00030+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11	"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Gluconeogenesis";"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"Methane metabolism"
XP_053948450.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_053950753.1	3	Reactome: R-HSA-1369062;Reactome: R-HSA-8964058;Reactome: R-HSA-9029569	"ABC transporters in lipid homeostasis";"HDL remodeling";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_053960443.1	42	Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-912446;Reactome: R-HSA-9018519;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-977225;Reactome: R-HSA-5693571;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-5334118;Reactome: R-HSA-73728;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-3214858;Reactome: R-HSA-3214815;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-427413;Reactome: R-HSA-2299718;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-5578749;Reactome: R-HSA-427359	"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"Meiotic recombination";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Amyloid fiber formation";"Nonhomologous End-Joining (NHEJ)";"Meiotic synapsis";"Packaging Of Telomere Ends";"DNA methylation";"RNA Polymerase I Promoter Opening";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RMTs methylate histone arginines";"HDACs deacetylate histones";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"NoRC negatively regulates rRNA expression";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression"
XP_053966811.1	7	Reactome: R-HSA-1483166;MetaCyc: PWY-3561;Reactome: R-HSA-2029485;KEGG: 00565+3.1.4.4;MetaCyc: PWY-7039;Reactome: R-HSA-1483148;KEGG: 00564+3.1.4.4	"Synthesis of PA";"Choline biosynthesis III";"Role of phospholipids in phagocytosis";"Ether lipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Synthesis of PG";"Glycerophospholipid metabolism"
XP_053959264.1	22	Reactome: R-HSA-2500257;Reactome: R-HSA-5673000;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-6811558;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-432142;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340	"Resolution of Sister Chromatid Cohesion";"RAF activation";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"Platelet sensitization by LDL";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex"
XP_053951488.1	5	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-196025;Reactome: R-HSA-190873;Reactome: R-HSA-3928665	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Formation of annular gap junctions";"Gap junction degradation";"EPH-ephrin mediated repulsion of cells"
XP_053967959.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053969690.1	2	Reactome: R-HSA-6798695;MetaCyc: PWY-7511	"Neutrophil degranulation";"Protein ubiquitination"
XP_053948025.1	2	Reactome: R-HSA-111458;Reactome: R-HSA-9627069	"Formation of apoptosome";"Regulation of the apoptosome activity"
XP_053967219.1	10	MetaCyc: PWY-1722;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-2201;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-5030;MetaCyc: PWY-3841;MetaCyc: PWY-5497;MetaCyc: PWY-6613;MetaCyc: PWY-7909;Reactome: R-HSA-196757	"Formate assimilation into 5,10-methylenetetrahydrofolate";"One carbon pool by folate";"Folate transformations I";"Carbon fixation pathways in prokaryotes";"L-histidine degradation III";"Folate transformations II (plants)";"Purine nucleobases degradation II (anaerobic)";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"Metabolism of folate and pterines"
XP_053964572.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_053959141.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053953030.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053962102.1	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053949812.1	2	Reactome: R-HSA-5693554;Reactome: R-HSA-2564830	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Cytosolic iron-sulfur cluster assembly"
XP_053950316.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053961233.1	4	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-6794361;Reactome: R-HSA-5250958	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Neurexins and neuroligins";"Toxicity of botulinum toxin type B (BoNT/B)"
XP_053962529.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_053953919.1	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
XP_053961117.1	16	MetaCyc: PWY-6886;MetaCyc: PWY-1042;Reactome: R-HSA-70263;MetaCyc: PWY-5484;MetaCyc: PWY-7003;KEGG: 00680+4.2.1.11;MetaCyc: PWY-6901;MetaCyc: PWY-7124;MetaCyc: PWY-7218;MetaCyc: PWY-6142;KEGG: 00010+4.2.1.11;MetaCyc: PWY-5723;Reactome: R-HSA-70171;MetaCyc: PWY-1622;MetaCyc: PWY-8004;MetaCyc: PWY-2221	"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Glycerol degradation to butanol";"Methane metabolism";"Superpathway of glucose and xylose degradation";"Ethylene biosynthesis V (engineered)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis / Gluconeogenesis";"Rubisco shunt";"Glycolysis";"Formaldehyde assimilation I (serine pathway)";"Entner-Doudoroff pathway I";"Entner-Doudoroff pathway III (semi-phosphorylative)"
XP_053946215.1	2	Reactome: R-HSA-425393;Reactome: R-HSA-5223345	"Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events"
XP_053953252.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053958665.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053958092.1	17	Reactome: R-HSA-141444;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5663220;KEGG: 04926+2.7.11.1;Reactome: R-HSA-174178;Reactome: R-HSA-2467813;KEGG: 04714+2.7.11.1;Reactome: R-HSA-2500257;KEGG: 05170+2.7.11.1;Reactome: R-HSA-9022692;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-9648025;Reactome: R-HSA-6804756;KEGG: 05163+2.7.11.1	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"RHO GTPases Activate Formins";"Relaxin signaling pathway";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Separation of Sister Chromatids";"Thermogenesis";"Resolution of Sister Chromatid Cohesion";"Human immunodeficiency virus 1 infection";"Regulation of MECP2 expression and activity";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"EML4 and NUDC in mitotic spindle formation";"Regulation of TP53 Activity through Phosphorylation";"Human cytomegalovirus infection"
XP_053953259.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053960576.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053959738.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053966851.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_053953171.1	11	Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-163359;Reactome: R-HSA-170670;Reactome: R-HSA-163615;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555	"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"G alpha (i) signalling events";"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway";"PKA activation";"Purine metabolism";"G alpha (s) signalling events"
XP_053956332.1	32	Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-77075;Reactome: R-HSA-167160;Reactome: R-HSA-167162;Reactome: R-HSA-167287;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-72163;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167172;Reactome: R-HSA-72203;Reactome: R-HSA-73779;Reactome: R-HSA-75953;Reactome: R-HSA-72165;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-168325;Reactome: R-HSA-167242;Reactome: R-HSA-6803529	"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II HIV Promoter Escape";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"mRNA Splicing - Major Pathway";"mRNA Capping";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Transcription of the HIV genome";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation";"mRNA Splicing - Minor Pathway";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"Viral Messenger RNA Synthesis";"Abortive elongation of HIV-1 transcript in the absence of Tat";"FGFR2 alternative splicing"
XP_053956473.1	9	Reactome: R-HSA-6804756;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776	"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape"
XP_053959500.1	4	Reactome: R-HSA-351202;KEGG: 00330+4.1.1.50;MetaCyc: PWY-6834;KEGG: 00270+4.1.1.50	"Metabolism of polyamines";"Arginine and proline metabolism";"Spermidine biosynthesis III";"Cysteine and methionine metabolism"
XP_053948410.1	4	Reactome: R-HSA-189451;MetaCyc: PWY-5189;KEGG: 00860+4.2.1.75;MetaCyc: PWY-5188	"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)"
XP_053950713.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053964713.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053959050.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_053953710.1	5	Reactome: R-HSA-166166;Reactome: R-HSA-168164;Reactome: R-HSA-937072;Reactome: R-HSA-937041;Reactome: R-HSA-936964	"MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IKK complex recruitment mediated by RIP1";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"
XP_053959261.1	2	Reactome: R-HSA-390918;Reactome: R-HSA-9033241	"Peroxisomal lipid metabolism";"Peroxisomal protein import"
XP_053965673.1	3	Reactome: R-HSA-4090294;Reactome: R-HSA-3232118;Reactome: R-HSA-3899300	"SUMOylation of intracellular receptors";"SUMOylation of transcription factors";"SUMOylation of transcription cofactors"
XP_053966814.1	7	KEGG: 00564+3.1.4.4;MetaCyc: PWY-7039;Reactome: R-HSA-1483148;KEGG: 00565+3.1.4.4;Reactome: R-HSA-2029485;MetaCyc: PWY-3561;Reactome: R-HSA-1483166	"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Synthesis of PG";"Ether lipid metabolism";"Role of phospholipids in phagocytosis";"Choline biosynthesis III";"Synthesis of PA"
XP_053960319.1	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
XP_053954576.1	24	Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-114604;Reactome: R-HSA-389357;KEGG: 05163+2.7.11.1;Reactome: R-HSA-165158;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5625740;KEGG: 05165+2.7.11.1;Reactome: R-HSA-1257604;KEGG: 04926+2.7.11.1;Reactome: R-HSA-354192;Reactome: R-HSA-5674400;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-392451;Reactome: R-HSA-5218921;Reactome: R-HSA-9634635;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-2730905;Reactome: R-HSA-5607764;Reactome: R-HSA-444257;KEGG: 04151+2.7.11.1	"Downstream TCR signaling";"FCERI mediated NF-kB activation";"GPVI-mediated activation cascade";"CD28 dependent PI3K/Akt signaling";"Human cytomegalovirus infection";"Activation of AKT2";"mTOR signaling pathway";"RHO GTPases activate PKNs";"Human papillomavirus infection";"PIP3 activates AKT signaling";"Relaxin signaling pathway";"Integrin signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"Thermogenesis";"Human immunodeficiency virus 1 infection";"G beta:gamma signalling through PI3Kgamma";"VEGFR2 mediated cell proliferation";"Estrogen-stimulated signaling through PRKCZ";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"Role of LAT2/NTAL/LAB on calcium mobilization";"CLEC7A (Dectin-1) signaling";"RSK activation";"PI3K-Akt signaling pathway"
XP_053962858.1	7	KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053948166.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053949520.1	11	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-2559580;Reactome: R-HSA-4420097;Reactome: R-HSA-450302;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"p38MAPK events";"Oxidative Stress Induced Senescence";"VEGFA-VEGFR2 Pathway";"activated TAK1 mediates p38 MAPK activation";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053966336.1	3	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-383280	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Nuclear Receptor transcription pathway"
XP_053953758.1	3	MetaCyc: PWY-3961;Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33	"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_053964927.1	5	Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9615710;Reactome: R-HSA-9610379;Reactome: R-HSA-174490	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"Late endosomal microautophagy";"HCMV Late Events";"Membrane binding and targetting of GAG proteins"
XP_053964641.1	14	Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-8943723;Reactome: R-HSA-9022692;Reactome: R-HSA-8934593;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-426486;Reactome: R-HSA-203927;Reactome: R-HSA-5628897;Reactome: R-HSA-8986944;Reactome: R-HSA-9018519	"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Regulation of PTEN mRNA translation";"Regulation of MECP2 expression and activity";"Regulation of RUNX1 Expression and Activity";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by MECP2";"Estrogen-dependent gene expression"
XP_053965734.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053954675.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053958005.1	4	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_053963265.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053961101.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053963256.1	6	MetaCyc: PWY-622;KEGG: 00500+2.4.1.18;Reactome: R-HSA-189085;MetaCyc: PWY-7900;MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1	"Starch biosynthesis";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism"
XP_053952368.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053966854.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_053954443.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053965011.1	3	KEGG: 00520+1.1.1.271;Reactome: R-HSA-6787639;KEGG: 00051+1.1.1.271	"Amino sugar and nucleotide sugar metabolism";"GDP-fucose biosynthesis";"Fructose and mannose metabolism"
XP_053964753.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_053953750.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053947457.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053952360.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053965667.1	3	Reactome: R-HSA-3899300;Reactome: R-HSA-3232118;Reactome: R-HSA-4090294	"SUMOylation of transcription cofactors";"SUMOylation of transcription factors";"SUMOylation of intracellular receptors"
XP_053962277.1	10	KEGG: 00010+2.7.1.11;KEGG: 00051+2.7.1.11;MetaCyc: PWY-7385;KEGG: 00052+2.7.1.11;MetaCyc: PWY-1042;KEGG: 00030+2.7.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-1861;Reactome: R-HSA-70171;KEGG: 00680+2.7.1.11	"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"1,3-propanediol biosynthesis (engineered)";"Galactose metabolism";"Glycolysis IV (plant cytosol)";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis";"Methane metabolism"
XP_053954866.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053957327.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053965557.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053947404.1	4	MetaCyc: PWY-6483;MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662	"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism";"Glycosphingolipid metabolism"
XP_053947311.1	4	Reactome: R-HSA-975138;Reactome: R-HSA-6799198;Reactome: R-HSA-975871;Reactome: R-HSA-166058	"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"Complex I biogenesis";"MyD88 cascade initiated on plasma membrane";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane"
XP_053969470.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053946146.1	5	Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"Deactivation of the beta-catenin transactivating complex"
XP_053966503.1	4	Reactome: R-HSA-2173789;Reactome: R-HSA-3656532;Reactome: R-HSA-2173788;Reactome: R-HSA-3304356	"TGF-beta receptor signaling activates SMADs";"TGFBR1 KD Mutants in Cancer";"Downregulation of TGF-beta receptor signaling";"SMAD2/3 Phosphorylation Motif Mutants in Cancer"
XP_053947646.1	2	Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198	"Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"
XP_053953718.1	4	MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3	"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Purine metabolism"
XP_053959058.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_053961548.1	6	Reactome: R-HSA-381426;Reactome: R-HSA-201722;Reactome: R-HSA-2173796;Reactome: R-HSA-5626467;Reactome: R-HSA-3769402;Reactome: R-HSA-8957275	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Formation of the beta-catenin:TCF transactivating complex";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"RHO GTPases activate IQGAPs";"Deactivation of the beta-catenin transactivating complex";"Post-translational protein phosphorylation"
XP_053950862.1	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
XP_053945185.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053966221.1	10	KEGG: 00531+3.2.1.23;Reactome: R-HSA-6798695;MetaCyc: PWY-6807;Reactome: R-HSA-2024096;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2160916;Reactome: R-HSA-2206292;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00600+3.2.1.23	"Glycosaminoglycan degradation";"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"HS-GAG degradation";"Glycosphingolipid biosynthesis - ganglio series";"Hyaluronan uptake and degradation";"MPS VII - Sly syndrome";"Other glycan degradation";"Galactose metabolism";"Sphingolipid metabolism"
XP_053947337.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053951890.1	16	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_053960373.1	42	Reactome: R-HSA-5250924;Reactome: R-HSA-3214858;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-977225;Reactome: R-HSA-5693571;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-5334118;Reactome: R-HSA-9018519;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-912446;Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-427413;Reactome: R-HSA-2299718;Reactome: R-HSA-69473;Reactome: R-HSA-110330;Reactome: R-HSA-3214842	"B-WICH complex positively regulates rRNA expression";"RMTs methylate histone arginines";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Amyloid fiber formation";"Nonhomologous End-Joining (NHEJ)";"Meiotic synapsis";"Packaging Of Telomere Ends";"DNA methylation";"Estrogen-dependent gene expression";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"Meiotic recombination";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"NoRC negatively regulates rRNA expression";"Condensation of Prophase Chromosomes";"G2/M DNA damage checkpoint";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones"
XP_053960925.1	13	KEGG: 05163+2.7.11.1;Reactome: R-HSA-6802952;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6802955;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6802946;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;KEGG: 04150+2.7.11.1;Reactome: R-HSA-9649948	"Human cytomegalovirus infection";"Signaling by BRAF and RAF fusions";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Signaling by moderate kinase activity BRAF mutants";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"mTOR signaling pathway";"Signaling downstream of RAS mutants"
XP_053959177.1	1	Reactome: R-HSA-114608	"Platelet degranulation"
XP_053953822.1	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
XP_053969906.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_053966416.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053949929.1	3	Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621	"Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism"
XP_053963991.1	13	MetaCyc: PWY-7721;MetaCyc: PWY-6859;MetaCyc: PWY-6383;MetaCyc: PWY-5122;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-5123;MetaCyc: PWY-7182;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-7709	"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Linalool biosynthesis I";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"(3R)-linalool biosynthesis"
XP_053968011.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_053961949.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053963286.1	6	KEGG: 04070+3.1.3.56;KEGG: 00562+3.1.3.56;MetaCyc: PWY-6364;MetaCyc: PWY-6363;MetaCyc: PWY-6362;Reactome: R-HSA-1855183	"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Synthesis of IP2, IP, and Ins in the cytosol"
XP_053962729.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1482798	"Mitochondrial protein import";"Acyl chain remodeling of CL"
XP_053962244.1	5	Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-69205;Reactome: R-HSA-68867;Reactome: R-HSA-68962	"CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"G1/S-Specific Transcription";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex"
XP_053961134.1	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
XP_053960461.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053968667.1	4	Reactome: R-HSA-1170546;Reactome: R-HSA-2586552;Reactome: R-HSA-983231;Reactome: R-HSA-982772	"Prolactin receptor signaling";"Signaling by Leptin";"Factors involved in megakaryocyte development and platelet production";"Growth hormone receptor signaling"
XP_053951115.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950278.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_053947381.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387	"Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling"
XP_053950804.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053959708.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053967147.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_053956309.1	9	Reactome: R-HSA-975634;Reactome: R-HSA-3560801;Reactome: R-HSA-2024096;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;Reactome: R-HSA-3560783;Reactome: R-HSA-1971475;Reactome: R-HSA-4420332;Reactome: R-HSA-3656253	"Retinoid metabolism and transport";"Defective B3GAT3 causes JDSSDHD";"HS-GAG degradation";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Defective B4GALT7 causes EDS, progeroid type";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS"
XP_053966921.1	2	Reactome: R-HSA-426117;Reactome: R-HSA-5619039	"Cation-coupled Chloride cotransporters";"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)"
XP_053958715.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053951308.1	4	Reactome: R-HSA-2161541;KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221;Reactome: R-HSA-499943	"Abacavir metabolism";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates"
XP_053964497.1	17	Reactome: R-HSA-3371599;MetaCyc: PWY-4381;Reactome: R-HSA-163765;MetaCyc: PWY-5744;KEGG: 00720+6.4.1.2;Reactome: R-HSA-196780;Reactome: R-HSA-2426168;MetaCyc: PWY-5966-1;KEGG: 00620+6.4.1.2;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6722;MetaCyc: PWY-6679;KEGG: 00254+6.4.1.2;KEGG: 00640+6.4.1.2;MetaCyc: PWY-5789;Reactome: R-HSA-200425;MetaCyc: PWY-5743	"Defective HLCS causes multiple carboxylase deficiency";"Fatty acid biosynthesis initiation (bacteria and plants)";"ChREBP activates metabolic gene expression";"Glyoxylate assimilation";"Carbon fixation pathways in prokaryotes";"Biotin transport and metabolism";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Pyruvate metabolism";"Fatty acid biosynthesis";"Candicidin biosynthesis";"Jadomycin biosynthesis";"Aflatoxin biosynthesis";"Propanoate metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Carnitine metabolism";"3-hydroxypropanoate cycle"
XP_053965096.1	2	Reactome: R-HSA-432720;Reactome: R-HSA-432722	"Lysosome Vesicle Biogenesis";"Golgi Associated Vesicle Biogenesis"
XP_053960382.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053964783.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053953780.1	2	KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386	"Pyruvate metabolism";"Methylglyoxal degradation I"
XP_053946825.1	4	KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174;Reactome: R-HSA-1237112;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053947487.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053962161.1	14	Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167246;Reactome: R-HSA-167242;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-75955	"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated elongation of the HIV-1 transcript";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation"
XP_053951166.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053947431.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053963291.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053953000.1	13	Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053964003.1	23	Reactome: R-HSA-418592;Reactome: R-HSA-392170;Reactome: R-HSA-381676;Reactome: R-HSA-392851;Reactome: R-HSA-416482;Reactome: R-HSA-9009391;Reactome: R-HSA-6814122;Reactome: R-HSA-8964315;Reactome: R-HSA-418594;Reactome: R-HSA-456926;Reactome: R-HSA-8964616;Reactome: R-HSA-428930;Reactome: R-HSA-420092;Reactome: R-HSA-500657;Reactome: R-HSA-400042;Reactome: R-HSA-432040;Reactome: R-HSA-4086398;Reactome: R-HSA-418555;Reactome: R-HSA-202040;Reactome: R-HSA-418217;Reactome: R-HSA-392451;Reactome: R-HSA-416476;Reactome: R-HSA-418597	"ADP signalling through P2Y purinoceptor 1";"ADP signalling through P2Y purinoceptor 12";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Prostacyclin signalling through prostacyclin receptor";"G alpha (12/13) signalling events";"Extra-nuclear estrogen signaling";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through BTK";"G alpha (i) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through CDC42";"Thromboxane signalling through TP receptor";"Glucagon-type ligand receptors";"Presynaptic function of Kainate receptors";"Adrenaline,noradrenaline inhibits insulin secretion";"Vasopressin regulates renal water homeostasis via Aquaporins";"Ca2+ pathway";"G alpha (s) signalling events";"G-protein activation";"G beta:gamma signalling through PLC beta";"G beta:gamma signalling through PI3Kgamma";"G alpha (q) signalling events";"G alpha (z) signalling events"
XP_053950553.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053961242.1	27	Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-180910;Reactome: R-HSA-159230;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-168333	"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP Dependant Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"ISG15 antiviral mechanism";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"NEP/NS2 Interacts with the Cellular Export Machinery"
XP_053964049.1	3	Reactome: R-HSA-2022928;KEGG: 00534+5.1.3.17;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Heparan sulfate biosynthesis (late stages)"
XP_053963986.1	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053961249.1	2	Reactome: R-HSA-110320;Reactome: R-HSA-983168	"Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053961724.1	13	Reactome: R-HSA-3000157;Reactome: R-HSA-1442490;Reactome: R-HSA-2022090;Reactome: R-HSA-419037;Reactome: R-HSA-1474244;Reactome: R-HSA-3000178;Reactome: R-HSA-216083;Reactome: R-HSA-2214320;Reactome: R-HSA-186797;Reactome: R-HSA-3000171;Reactome: R-HSA-2243919;Reactome: R-HSA-8948216;Reactome: R-HSA-1650814	"Laminin interactions";"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures";"NCAM1 interactions";"Extracellular matrix organization";"ECM proteoglycans";"Integrin cell surface interactions";"Anchoring fibril formation";"Signaling by PDGF";"Non-integrin membrane-ECM interactions";"Crosslinking of collagen fibrils";"Collagen chain trimerization";"Collagen biosynthesis and modifying enzymes"
XP_053967829.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053947396.1	4	MetaCyc: PWY-6483;MetaCyc: PWY-7119;Reactome: R-HSA-1660662;KEGG: 00600+3.5.1.23	"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)";"Glycosphingolipid metabolism";"Sphingolipid metabolism"
XP_053954464.1	1	Reactome: R-HSA-2465910	"MASTL Facilitates Mitotic Progression"
XP_053951155.1	3	Reactome: R-HSA-5617472;Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053962944.1	4	KEGG: 00513+2.4.1.258;Reactome: R-HSA-446193;Reactome: R-HSA-4720475;KEGG: 00510+2.4.1.258	"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG3 causes ALG3-CDG (CDG-1d)";"N-Glycan biosynthesis"
XP_053950978.1	4	Reactome: R-HSA-5205685;Reactome: R-HSA-1632852;Reactome: R-HSA-8934903;Reactome: R-HSA-936440	"Pink/Parkin Mediated Mitophagy";"Macroautophagy";"Receptor Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling"
XP_053966465.1	7	Reactome: R-HSA-9010553;Reactome: R-HSA-5173105;Reactome: R-HSA-5083633;Reactome: R-HSA-5083629;Reactome: R-HSA-3000178;Reactome: R-HSA-5083628;Reactome: R-HSA-3000171	"Regulation of expression of SLITs and ROBOs";"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"ECM proteoglycans";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Non-integrin membrane-ECM interactions"
XP_053952202.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053956081.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053947820.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053952209.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions"
XP_053957971.1	3	MetaCyc: PWY-7856;Reactome: R-HSA-189451;KEGG: 00860+2.5.1.141	"Heme a biosynthesis";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_053950290.1	10	MetaCyc: PWY-7112;MetaCyc: PWY-7559;MetaCyc: PWY-5826;MetaCyc: PWY-4041;KEGG: 00460+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-4061;MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;MetaCyc: PWY-6842	"4-hydroxy-2-nonenal detoxification";"Glutathione degradation (DUG pathway";"Hypoglycin biosynthesis";"Gamma-glutamyl cycle";"Cyanoamino acid metabolism";"Glutathione metabolism";"Glutathione-mediated detoxification I";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Glutathione-mediated detoxification II"
XP_053960737.1	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
XP_053951904.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053947841.1	16	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-72695	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex"
XP_053960001.1	4	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-6807505	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"RNA polymerase II transcribes snRNA genes"
XP_053960514.1	42	Reactome: R-HSA-9018519;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-212300;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-2559580;Reactome: R-HSA-912446;Reactome: R-HSA-3214815;Reactome: R-HSA-5250924;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-73728;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5334118;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-427413;Reactome: R-HSA-69473;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-2299718;Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-110331;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-5693607	"Estrogen-dependent gene expression";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"PRC2 methylates histones and DNA";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Oxidative Stress Induced Senescence";"Meiotic recombination";"HDACs deacetylate histones";"B-WICH complex positively regulates rRNA expression";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Opening";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"DNA methylation";"Meiotic synapsis";"Packaging Of Telomere Ends";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"NoRC negatively regulates rRNA expression";"G2/M DNA damage checkpoint";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"Condensation of Prophase Chromosomes";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"Cleavage of the damaged purine";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Processing of DNA double-strand break ends"
XP_053951560.1	14	KEGG: 00564+2.3.1.51;MetaCyc: PWY-5667;MetaCyc: PWY-7417;MetaCyc: PWY-8053;MetaCyc: PWY-7411;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-5981;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-7587;MetaCyc: PWY-8055;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.51	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Phosphatidate biosynthesis (yeast)";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis III";"Synthesis of PA";"Plasmalogen biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism"
XP_053955221.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053945618.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
XP_053957119.1	14	Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-113418;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167242;Reactome: R-HSA-167246	"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the Early Elongation Complex";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Tat-mediated elongation of the HIV-1 transcript"
XP_053965076.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053950535.1	8	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-975957;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053954661.1	12	Reactome: R-HSA-3371497;Reactome: R-HSA-380320;Reactome: R-HSA-6811436;Reactome: R-HSA-381038;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of NuMA to mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"XBP1(S) activates chaperone genes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition"
XP_053963271.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053951650.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053946903.1	6	KEGG: 00680+5.4.2.11;MetaCyc: PWY-8004;KEGG: 00260+5.4.2.11;MetaCyc: PWY-5484;MetaCyc: PWY-1622;KEGG: 00010+5.4.2.11	"Methane metabolism";"Entner-Doudoroff pathway I";"Glycine, serine and threonine metabolism";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation I (serine pathway)";"Glycolysis / Gluconeogenesis"
XP_053951878.1	5	Reactome: R-HSA-3371497;Reactome: R-HSA-6798695;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Neutrophil degranulation";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation"
XP_053953026.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053951217.1	6	Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation"
XP_053969928.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053946134.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_053956037.1	5	Reactome: R-HSA-4719360;Reactome: R-HSA-162699;Reactome: R-HSA-4719377;Reactome: R-HSA-4717374;Reactome: R-HSA-162710	"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Synthesis of dolichyl-phosphate mannose";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM1 causes DPM1-CDG (CDG-1e)";"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053959136.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950374.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053969941.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053960127.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053957271.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053945723.1	14	MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-8041	"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis"
XP_053969627.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053951658.1	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
XP_053958491.1	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
XP_053945658.1	4	KEGG: 05235+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"DARPP-32 events";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053950990.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_053966005.1	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
XP_053965302.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053945870.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
XP_053958336.1	6	Reactome: R-HSA-5632928;Reactome: R-HSA-5632927;Reactome: R-HSA-6796648;Reactome: R-HSA-5632968;Reactome: R-HSA-5358565;Reactome: R-HSA-5358606	"Defective Mismatch Repair Associated With MSH2";"Defective Mismatch Repair Associated With MSH3";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"
XP_053954511.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_053956531.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_053954004.1	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
XP_053946724.1	5	Reactome: R-HSA-72163;Reactome: R-HSA-6784531;Reactome: R-HSA-72187;Reactome: R-HSA-77595;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"tRNA processing in the nucleus";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination"
XP_053946249.1	13	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-177504;Reactome: R-HSA-167590;Reactome: R-HSA-437239;Reactome: R-HSA-416993;Reactome: R-HSA-3928665;Reactome: R-HSA-5099900;Reactome: R-HSA-5140745;Reactome: R-HSA-8866427;Reactome: R-HSA-8964038;Reactome: R-HSA-2132295;Reactome: R-HSA-182218	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Retrograde neurotrophin signalling";"Nef Mediated CD4 Down-regulation";"Recycling pathway of L1";"Trafficking of GluR2-containing AMPA receptors";"EPH-ephrin mediated repulsion of cells";"WNT5A-dependent internalization of FZD4";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"VLDLR internalisation and degradation";"LDL clearance";"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation"
XP_053963971.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_053954784.1	3	Reactome: R-HSA-5689603;Reactome: R-HSA-3214847;Reactome: R-HSA-5696394	"UCH proteinases";"HATs acetylate histones";"DNA Damage Recognition in GG-NER"
XP_053945568.1	10	Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-9018519;Reactome: R-HSA-73776;Reactome: R-HSA-6807505;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-75953	"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"Estrogen-dependent gene expression";"RNA Polymerase II Promoter Escape";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation"
XP_053959726.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053966785.1	83	Reactome: R-HSA-2871796;Reactome: R-HSA-186763;Reactome: R-HSA-512988;Reactome: R-HSA-2219530;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-1839117;Reactome: R-HSA-8875656;Reactome: R-HSA-5655302;Reactome: R-HSA-5654732;Reactome: R-HSA-8856825;Reactome: R-HSA-9027284;Reactome: R-HSA-2428933;Reactome: R-HSA-9028731;Reactome: R-HSA-74749;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-8853659;Reactome: R-HSA-8851907;Reactome: R-HSA-5655253;Reactome: R-HSA-2424491;Reactome: R-HSA-8983432;Reactome: R-HSA-983695;Reactome: R-HSA-8875555;Reactome: R-HSA-5654700;Reactome: R-HSA-5654693;Reactome: R-HSA-112412;Reactome: R-HSA-6811558;Reactome: R-HSA-8853338;Reactome: R-HSA-5654706;Reactome: R-HSA-9645135;Reactome: R-HSA-8865999;Reactome: R-HSA-5654712;Reactome: R-HSA-210993;Reactome: R-HSA-5654710;Reactome: R-HSA-912631;Reactome: R-HSA-391160;Reactome: R-HSA-389359;Reactome: R-HSA-74751;Reactome: R-HSA-5663213;Reactome: R-HSA-1433559;Reactome: R-HSA-8875360;Reactome: R-HSA-354194;Reactome: R-HSA-5654695;Reactome: R-HSA-1250347;Reactome: R-HSA-9664565;Reactome: R-HSA-5654688;Reactome: R-HSA-8851805;Reactome: R-HSA-5673001;Reactome: R-HSA-180292;Reactome: R-HSA-375165;Reactome: R-HSA-180336;Reactome: R-HSA-6807004;Reactome: R-HSA-9028335;Reactome: R-HSA-1236382;Reactome: R-HSA-182971;Reactome: R-HSA-9034864;Reactome: R-HSA-1250196;Reactome: R-HSA-388841;Reactome: R-HSA-1257604;Reactome: R-HSA-2029482;Reactome: R-HSA-9026519;Reactome: R-HSA-179812;Reactome: R-HSA-1295596;Reactome: R-HSA-9634285;Reactome: R-HSA-5654720;Reactome: R-HSA-9607240;Reactome: R-HSA-5637810;Reactome: R-HSA-5654699;Reactome: R-HSA-5654719;Reactome: R-HSA-167044;Reactome: R-HSA-2730905;Reactome: R-HSA-1433557;Reactome: R-HSA-8856828;Reactome: R-HSA-5654727;Reactome: R-HSA-1963640;Reactome: R-HSA-5654726;Reactome: R-HSA-5655291;Reactome: R-HSA-912526;Reactome: R-HSA-8853334;Reactome: R-HSA-1963642;Reactome: R-HSA-5654704;Reactome: R-HSA-2871809	"FCERI mediated MAPK activation";"Downstream signal transduction";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"Signaling by cytosolic FGFR1 fusion mutants";"MET receptor recycling";"Signaling by FGFR1 in disease";"Negative regulation of FGFR3 signaling";"Cargo recognition for clathrin-mediated endocytosis";"Erythropoietin activates RAS";"SHC-related events triggered by IGF1R";"Activated NTRK2 signals through FRS2 and FRS3";"Signal attenuation";"EGFR Transactivation by Gastrin";"PI3K Cascade";"RET signaling";"MET activates PI3K/AKT signaling";"Signaling by FGFR2 in disease";"DAP12 signaling";"Interleukin-15 signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"MET activates RAP1 and RAC1";"FRS-mediated FGFR2 signaling";"FRS-mediated FGFR1 signaling";"SOS-mediated signalling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Signaling by FGFR3 point mutants in cancer";"FRS-mediated FGFR3 signaling";"STAT5 Activation";"MET activates PTPN11";"FRS-mediated FGFR4 signaling";"Tie2 Signaling";"PI-3K cascade:FGFR3";"Regulation of signaling by CBL";"Signal regulatory protein family interactions";"CD28 dependent Vav1 pathway";"Insulin receptor signalling cascade";"RHO GTPases Activate WASPs and WAVEs";"Regulation of KIT signaling";"InlB-mediated entry of Listeria monocytogenes into host cell";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"PI-3K cascade:FGFR2";"SHC1 events in ERBB4 signaling";"Signaling by ERBB2 KD Mutants";"SHC-mediated cascade:FGFR1";"MET activates RAS signaling";"RAF/MAP kinase cascade";"GAB1 signalosome";"NCAM signaling for neurite out-growth";"SHC1 events in EGFR signaling";"Negative regulation of MET activity";"Activated NTRK2 signals through PI3K";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"EGFR downregulation";"Activated NTRK3 signals through RAS";"SHC1 events in ERBB2 signaling";"Costimulation by the CD28 family";"PIP3 activates AKT signaling";"Regulation of actin dynamics for phagocytic cup formation";"Activated NTRK2 signals through RAS";"GRB2 events in EGFR signaling";"Spry regulation of FGF signaling";"Constitutive Signaling by Overexpressed ERBB2";"PI-3K cascade:FGFR4";"FLT3 Signaling";"Constitutive Signaling by EGFRvIII";"SHC-mediated cascade:FGFR2";"SHC-mediated cascade:FGFR4";"Signalling to RAS";"Role of LAT2/NTAL/LAB on calcium mobilization";"Signaling by SCF-KIT";"Clathrin-mediated endocytosis";"Negative regulation of FGFR2 signaling";"GRB2 events in ERBB2 signaling";"Negative regulation of FGFR1 signaling";"Signaling by FGFR4 in disease";"Interleukin receptor SHC signaling";"Signaling by FGFR3 fusions in cancer";"PI3K events in ERBB2 signaling";"SHC-mediated cascade:FGFR3";"FCERI mediated Ca+2 mobilization"
XP_053955465.1	12	Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-167200	"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat"
XP_053956883.1	5	KEGG: 00670+1.5.1.3;KEGG: 00790+1.5.1.3;MetaCyc: PWY-3841;Reactome: R-HSA-196757;MetaCyc: PWY-6614	"One carbon pool by folate";"Folate biosynthesis";"Folate transformations II (plants)";"Metabolism of folate and pterines";"Tetrahydrofolate biosynthesis"
XP_053946242.1	14	Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-113418;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167246	"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the Early Elongation Complex";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript"
XP_053965899.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053960842.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053951917.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053964371.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_053958733.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-6811436	"RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic"
XP_053947009.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_053950705.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053966344.1	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
XP_053948326.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053954581.1	2	KEGG: 00770+2.7.1.24;MetaCyc: PWY-7851	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis II (eukaryotic)"
XP_053963624.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053948568.1	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
XP_053970223.1	2	KEGG: 04070+2.7.11.13;Reactome: R-HSA-1660661	"Phosphatidylinositol signaling system";"Sphingolipid de novo biosynthesis"
XP_053957173.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053951931.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053958456.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_053952730.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_053949333.1	16	Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-9633012	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_053956673.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053948723.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053962698.1	4	MetaCyc: PWY-5331;KEGG: 00430+1.13.11.20;KEGG: 00270+1.13.11.20;Reactome: R-HSA-1614558	"Taurine biosynthesis I";"Taurine and hypotaurine metabolism";"Cysteine and methionine metabolism";"Degradation of cysteine and homocysteine"
XP_053963189.1	6	KEGG: 00500+2.4.1.18;MetaCyc: PWY-622;MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1;MetaCyc: PWY-7900;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Starch biosynthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Digestion of dietary carbohydrate"
XP_053952128.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053951987.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_053970084.1	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
XP_053964735.1	3	Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13;Reactome: R-HSA-418597	"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"G alpha (z) signalling events"
XP_053954833.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053951680.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053954714.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053960751.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_053946101.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053954537.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053950066.1	4	Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_053955397.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053956667.1	4	Reactome: R-HSA-389661;Reactome: R-HSA-77289;Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Glyoxylate metabolism and glycine degradation";"Mitochondrial Fatty Acid Beta-Oxidation";"Respiratory electron transport";"Complex I biogenesis"
XP_053956689.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.4	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053945231.1	4	Reactome: R-HSA-2214320;Reactome: R-HSA-1474228;Reactome: R-HSA-1650814;Reactome: R-HSA-2243919	"Anchoring fibril formation";"Degradation of the extracellular matrix";"Collagen biosynthesis and modifying enzymes";"Crosslinking of collagen fibrils"
XP_053957182.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053954596.1	11	MetaCyc: PWY-7254;Reactome: R-HSA-71403;MetaCyc: PWY-7268;MetaCyc: PWY-6728;MetaCyc: PWY-5913;MetaCyc: PWY-7124;KEGG: 00720+1.1.1.42;MetaCyc: PWY-6549;MetaCyc: PWY-6969;KEGG: 00020+1.1.1.42;KEGG: 00480+1.1.1.42	"TCA cycle VII (acetate-producers)";"Citric acid cycle (TCA cycle)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"Ethylene biosynthesis V (engineered)";"Carbon fixation pathways in prokaryotes";"L-glutamine biosynthesis III";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citrate cycle (TCA cycle)";"Glutathione metabolism"
XP_053947064.1	2	Reactome: R-HSA-1799339;Reactome: R-HSA-6798695	"SRP-dependent cotranslational protein targeting to membrane";"Neutrophil degranulation"
XP_053948650.1	16	Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition"
XP_053955854.1	3	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109	"Glycerol degradation I";"Glycerolipid metabolism";"Triglyceride biosynthesis"
XP_053947759.1	16	Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956	"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_053950055.1	6	Reactome: R-HSA-69473;Reactome: R-HSA-176187;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938	"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)"
XP_053954707.1	4	MetaCyc: PWY-8040;KEGG: 00473+5.1.1.1;MetaCyc: PWY-7383;MetaCyc: PWY-8072	"Ansatrienin biosynthesis";"D-Alanine metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Alanine racemization"
XP_053962997.1	7	Reactome: R-HSA-1660499;Reactome: R-HSA-1855183;MetaCyc: PWY-6368;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1855204;Reactome: R-HSA-8856828	"Synthesis of PIPs at the plasma membrane";"Synthesis of IP2, IP, and Ins in the cytosol";"3-phosphoinositide degradation";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol";"Clathrin-mediated endocytosis"
XP_053949506.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053958416.1	1	Reactome: R-HSA-1614635	"Sulfur amino acid metabolism"
XP_053954031.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_053969529.1	12	KEGG: 00450+4.4.1.13;MetaCyc: PWY-801;MetaCyc: PWY-601;Reactome: R-HSA-71240;MetaCyc: PWY-7901;KEGG: 00380+2.6.1.7;MetaCyc: PWY-6309;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6842;MetaCyc: PWY-1187;MetaCyc: PWY-2821;MetaCyc: PWY-6936	"Selenocompound metabolism";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from tryptophan";"Tryptophan catabolism";"Glucosinolate biosynthesis from tyrosine";"Tryptophan metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Cysteine and methionine metabolism";"Glutathione-mediated detoxification II";"Glucosinolate biosynthesis from homomethionine";"Glucosinolate biosynthesis from phenylalanine";"Seleno-amino acid biosynthesis (plants)"
XP_053954087.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053954062.1	2	Reactome: R-HSA-72706;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition"
XP_053949126.1	9	Reactome: R-HSA-2871809;Reactome: R-HSA-193648;Reactome: R-HSA-4420097;Reactome: R-HSA-5218920;Reactome: R-HSA-194840;Reactome: R-HSA-2871796;Reactome: R-HSA-114604;Reactome: R-HSA-416482;Reactome: R-HSA-2029482	"FCERI mediated Ca+2 mobilization";"NRAGE signals death through JNK";"VEGFA-VEGFR2 Pathway";"VEGFR2 mediated vascular permeability";"Rho GTPase cycle";"FCERI mediated MAPK activation";"GPVI-mediated activation cascade";"G alpha (12/13) signalling events";"Regulation of actin dynamics for phagocytic cup formation"
XP_053950599.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053966694.1	1	Reactome: R-HSA-350562	"Regulation of ornithine decarboxylase (ODC)"
XP_053951287.1	5	Reactome: R-HSA-9610379;Reactome: R-HSA-174490;Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9615710	"HCMV Late Events";"Membrane binding and targetting of GAG proteins";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"Late endosomal microautophagy"
XP_053962236.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053969522.1	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
XP_053954695.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053954754.1	16	Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_053955549.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
XP_053964606.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053952738.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053945262.1	4	KEGG: 00250+6.3.4.4;Reactome: R-HSA-73817;KEGG: 00230+6.3.4.4;MetaCyc: PWY-7219	"Alanine, aspartate and glutamate metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis"
XP_053954170.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_053966755.1	14	MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7619;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601	"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"
XP_053952964.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053964444.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053949605.1	11	KEGG: 00240+2.1.3.2;MetaCyc: PWY-7400;KEGG: 00250+6.3.5.5;MetaCyc: PWY-5686;Reactome: R-HSA-500753;KEGG: 00240+3.5.2.3;MetaCyc: PWY-5154;MetaCyc: PWY-7791;KEGG: 00250+2.1.3.2;KEGG: 00240+6.3.5.5;MetaCyc: PWY-7790	"Pyrimidine metabolism";"L-arginine biosynthesis IV (archaebacteria)";"Alanine, aspartate and glutamate metabolism";"UMP biosynthesis I";"Pyrimidine biosynthesis";"Pyrimidine metabolism";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"UMP biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Pyrimidine metabolism";"UMP biosynthesis II"
XP_053968412.1	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
XP_053950444.1	13	Reactome: R-HSA-416482;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-416572;KEGG: 05163+2.7.11.1;Reactome: R-HSA-3928663;Reactome: R-HSA-5627117;Reactome: R-HSA-4420097;KEGG: 04151+2.7.11.1;Reactome: R-HSA-3928662;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1	"G alpha (12/13) signalling events";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Sema4D induced cell migration and growth-cone collapse";"Human cytomegalovirus infection";"EPHA-mediated growth cone collapse";"RHO GTPases Activate ROCKs";"VEGFA-VEGFR2 Pathway";"PI3K-Akt signaling pathway";"EPHB-mediated forward signaling";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway"
XP_053951523.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053965645.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053969670.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053950606.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_053969858.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053960754.1	3	KEGG: 00510+2.4.1.144;MetaCyc: PWY-7426;Reactome: R-HSA-975574	"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Reactions specific to the hybrid N-glycan synthesis pathway"
XP_053960695.1	5	Reactome: R-HSA-73863;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-73772;Reactome: R-HSA-427413	"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression"
XP_053967186.1	7	KEGG: 00220+3.5.1.2;KEGG: 00250+3.5.1.2;Reactome: R-HSA-8964539;KEGG: 00471+3.5.1.2;Reactome: R-HSA-5628897;MetaCyc: PWY-5921;Reactome: R-HSA-210500	"Arginine biosynthesis";"Alanine, aspartate and glutamate metabolism";"Glutamate and glutamine metabolism";"D-Glutamine and D-glutamate metabolism";"TP53 Regulates Metabolic Genes";"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate Neurotransmitter Release Cycle"
XP_053947918.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053959625.1	16	Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957	"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053957247.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053947582.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_053947258.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_053958079.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053949056.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053961255.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_053945103.1	3	Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355	"Nitric oxide stimulates guanylate cyclase";"Purine metabolism";"Smooth Muscle Contraction"
XP_053951934.1	9	Reactome: R-HSA-198323;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5674400	"AKT phosphorylates targets in the cytosol";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Constitutive Signaling by AKT1 E17K in Cancer"
XP_053965546.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053964055.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053954602.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518	"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2"
XP_053958072.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053958533.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_053969810.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_053967423.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053963621.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053965467.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_053953191.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053952232.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053949692.1	5	KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-3821;MetaCyc: PWY-6317;KEGG: 00520+2.7.1.6	"Galactose metabolism";"Stachyose degradation";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism"
XP_053965489.1	2	Reactome: R-HSA-70895;KEGG: 00280+1.1.1.31	"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation"
XP_053945934.1	6	MetaCyc: PWY-6124;MetaCyc: PWY-7234;MetaCyc: PWY-6123;Reactome: R-HSA-73817;KEGG: 00670+2.1.2.3;KEGG: 00230+3.5.4.10+2.1.2.3	"Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"One carbon pool by folate";"Purine metabolism"
XP_053970037.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053947210.1	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053969963.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053958742.1	8	Reactome: R-HSA-9639288;Reactome: R-HSA-77387;MetaCyc: PWY-7980;KEGG: 00195+7.1.2.2;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;KEGG: 00190+7.1.2.2;Reactome: R-HSA-983712	"Amino acids regulate mTORC1";"Insulin receptor recycling";"ATP biosynthesis";"Photosynthesis";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Oxidative phosphorylation";"Ion channel transport"
XP_053951760.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053969818.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-5627123	"Clathrin-mediated endocytosis";"RHO GTPases activate PAKs"
XP_053954751.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053960833.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_053966691.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_053959360.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053946233.1	2	Reactome: R-HSA-195253;Reactome: R-HSA-5689896	"Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases"
XP_053957621.1	7	Reactome: R-HSA-9609690;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-8953750;Reactome: R-HSA-8943724;Reactome: R-HSA-3214841	"HCMV Early Events";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Transcriptional Regulation by E2F6";"Regulation of PTEN gene transcription";"PKMTs methylate histone lysines"
XP_053947958.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053969850.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053962470.1	3	Reactome: R-HSA-8939902;Reactome: R-HSA-6785807;Reactome: R-HSA-8878166	"Regulation of RUNX2 expression and activity";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional regulation by RUNX2"
XP_053955851.1	3	KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Triglyceride biosynthesis";"Glycerol degradation I"
XP_053956014.1	11	Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-163359;Reactome: R-HSA-170670;Reactome: R-HSA-163615;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555	"PKA activation in glucagon signalling";"Hedgehog 'off' state";"G alpha (i) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway";"PKA activation";"Purine metabolism";"G alpha (s) signalling events"
XP_053946117.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_053969678.1	8	KEGG: 04926+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Activation of RAC1";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053965473.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_053947250.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053952932.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053958083.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053945234.1	4	Reactome: R-HSA-2214320;Reactome: R-HSA-1474228;Reactome: R-HSA-2243919;Reactome: R-HSA-1650814	"Anchoring fibril formation";"Degradation of the extracellular matrix";"Crosslinking of collagen fibrils";"Collagen biosynthesis and modifying enzymes"
XP_053952995.1	15	Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-2173796;Reactome: R-HSA-9018519;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-176034;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-6807505;Reactome: R-HSA-167246;Reactome: R-HSA-674695;Reactome: R-HSA-6796648	"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Estrogen-dependent gene expression";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Interactions of Tat with host cellular proteins";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes"
XP_053954849.1	1	Reactome: R-HSA-427652	"Sodium-coupled phosphate cotransporters"
XP_053967156.1	10	MetaCyc: PWY-6174;KEGG: 00900+2.3.3.10;MetaCyc: PWY-7391;MetaCyc: PWY-7524;KEGG: 00280+2.3.3.10;KEGG: 00650+2.3.3.10;KEGG: 00072+2.3.3.10;Reactome: R-HSA-1989781;MetaCyc: PWY-7571;MetaCyc: PWY-922	"Mevalonate pathway II (archaea)";"Terpenoid backbone biosynthesis";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway III (archaea)";"Valine, leucine and isoleucine degradation";"Butanoate metabolism";"Synthesis and degradation of ketone bodies";"PPARA activates gene expression";"Ferrichrome A biosynthesis";"Mevalonate pathway I"
XP_053963800.1	4	KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219	"Purine metabolism";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis"
XP_053967293.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053954507.1	10	KEGG: 00332+2.7.2.11+1.2.1.41;KEGG: 00330+1.2.1.41+2.7.2.11;KEGG: 00332+2.7.2.11;Reactome: R-HSA-8964539;KEGG: 00332+1.2.1.41;MetaCyc: PWY-6922;KEGG: 00330+2.7.2.11;KEGG: 00330+1.2.1.41;KEGG: 00330+2.7.2.11+1.2.1.41;KEGG: 00332+1.2.1.41+2.7.2.11	"Carbapenem biosynthesis";"Arginine and proline metabolism";"Carbapenem biosynthesis";"Glutamate and glutamine metabolism";"Carbapenem biosynthesis";"L-Ndelta-acetylornithine biosynthesis";"Arginine and proline metabolism";"Arginine and proline metabolism";"Arginine and proline metabolism";"Carbapenem biosynthesis"
XP_053950371.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053946131.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_053949706.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_053952177.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053970051.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053949893.1	6	MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1	"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism"
XP_053954664.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053962906.1	8	Reactome: R-HSA-70171;KEGG: 00524+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00520+2.7.1.1	"Glycolysis";"Neomycin, kanamycin and gentamicin biosynthesis";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Galactose metabolism";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Amino sugar and nucleotide sugar metabolism"
XP_053960784.1	1	Reactome: R-HSA-8943724	"Regulation of PTEN gene transcription"
XP_053966099.1	2	Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
XP_053955083.1	5	Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-6804758;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815	"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"Regulation of TP53 Activity through Acetylation";"Regulation of PTEN gene transcription";"HDACs deacetylate histones"
XP_053955224.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053965805.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053953116.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053961329.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_053965452.1	13	MetaCyc: PWY-5123;MetaCyc: PWY-7709;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-7182;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-6859;MetaCyc: PWY-7721;MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1	"Trans, trans-farnesyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Linalool biosynthesis I";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"All-trans-farnesol biosynthesis";"Methyl phomopsenoate biosynthesis";"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis"
XP_053966555.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053949349.1	5	Reactome: R-HSA-189085;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-7822;MetaCyc: PWY-6902	"Digestion of dietary carbohydrate";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)"
XP_053961322.1	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
XP_053946070.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_053952700.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053965459.1	5	KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7269	"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)"
XP_053964697.1	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
XP_053969729.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_053955168.1	11	Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-5610787;Reactome: R-HSA-164378	"G alpha (s) signalling events";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Glucagon signaling in metabolic regulation";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"G alpha (i) signalling events";"Hedgehog 'off' state";"PKA activation in glucagon signalling"
XP_053956084.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053961285.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053946162.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053963390.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053969722.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053957398.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_053952708.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053964636.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053952530.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.5	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053966341.1	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
XP_053948103.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_053955079.1	5	Reactome: R-HSA-427389;Reactome: R-HSA-6804758;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724	"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"Regulation of PTEN gene transcription"
XP_053963398.1	6	Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156827	"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_053960661.1	5	KEGG: 00073+2.3.1.20;Reactome: R-HSA-75109;KEGG: 00561+2.3.1.20;Reactome: R-HSA-1482883;Reactome: R-HSA-6798695	"Cutin, suberine and wax biosynthesis";"Triglyceride biosynthesis";"Glycerolipid metabolism";"Acyl chain remodeling of DAG and TAG";"Neutrophil degranulation"
XP_053964535.1	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
XP_053966515.1	6	Reactome: R-HSA-399997;Reactome: R-HSA-456926;Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-434316;Reactome: R-HSA-416476	"Acetylcholine regulates insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G alpha (q) signalling events"
XP_053960632.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053969132.1	6	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-4086398;Reactome: R-HSA-8951430;Reactome: R-HSA-3769402;Reactome: R-HSA-4411364	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Ca2+ pathway";"RUNX3 regulates WNT signaling";"Deactivation of the beta-catenin transactivating complex";"Binding of TCF/LEF:CTNNB1 to target gene promoters"
XP_053951201.1	18	MetaCyc: PWY-7783;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482839;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482801;MetaCyc: PWY-8053;MetaCyc: PWY-7417;Reactome: R-HSA-1482925;Reactome: R-HSA-1482788	"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"alpha-Linolenic acid metabolism";"Synthesis of PA";"Acyl chain remodelling of PE";"Glycerophospholipid metabolism";"Acyl chain remodelling of PS";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PG";"Acyl chain remodelling of PC"
XP_053965419.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-1268020	"Citric acid cycle (TCA cycle)";"Mitochondrial protein import"
XP_053961090.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053954001.1	3	Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-191859	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"snRNP Assembly"
XP_053963808.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_053954514.1	1	Reactome: R-HSA-901032	"ER Quality Control Compartment (ERQC)"
XP_053964290.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_053963022.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053948523.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_053958494.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053963029.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053945201.1	8	MetaCyc: PWY-7980;Reactome: R-HSA-983712;KEGG: 00195+7.1.2.2;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;KEGG: 00190+7.1.2.2;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"ATP biosynthesis";"Ion channel transport";"Photosynthesis";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Oxidative phosphorylation";"Insulin receptor recycling";"Amino acids regulate mTORC1"
XP_053948941.1	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
XP_053963254.1	6	MetaCyc: PWY-622;KEGG: 00500+2.4.1.18;MetaCyc: PWY-7900;KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;Reactome: R-HSA-189085	"Starch biosynthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Digestion of dietary carbohydrate"
XP_053969962.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053960839.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053947572.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053965736.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053967176.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_053960832.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_053958082.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053969931.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053956541.1	5	KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-3821;MetaCyc: PWY-6317;KEGG: 00520+2.7.1.6	"Galactose metabolism";"Stachyose degradation";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism"
XP_053958346.1	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
XP_053955637.1	179	Reactome: R-HSA-5658442;Reactome: R-HSA-1236974;Reactome: R-HSA-5689877;Reactome: R-HSA-9033241;Reactome: R-HSA-69601;Reactome: R-HSA-69541;Reactome: R-HSA-6781827;Reactome: R-HSA-174154;Reactome: R-HSA-6781823;Reactome: R-HSA-5689901;Reactome: R-HSA-5654727;Reactome: R-HSA-162588;Reactome: R-HSA-211733;Reactome: R-HSA-5654726;Reactome: R-HSA-975163;Reactome: R-HSA-69017;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-8849469;Reactome: R-HSA-8875360;Reactome: R-HSA-4608870;Reactome: R-HSA-532668;Reactome: R-HSA-445989;Reactome: R-HSA-8948747;Reactome: R-HSA-182971;Reactome: R-HSA-5687128;Reactome: R-HSA-1358803;Reactome: R-HSA-6807004;Reactome: R-HSA-175474;Reactome: R-HSA-4641258;Reactome: R-HSA-450302;Reactome: R-HSA-3322077;Reactome: R-HSA-5610785;Reactome: R-HSA-156902;Reactome: R-HSA-174084;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-977225;Reactome: R-HSA-9613829;Reactome: R-HSA-9636383;Reactome: R-HSA-2122948;Reactome: R-HSA-2173791;Reactome: R-HSA-2565942;Reactome: R-HSA-4641263;Reactome: R-HSA-5654732;Reactome: R-HSA-110314;Reactome: R-HSA-5656121;Reactome: R-HSA-9645460;Reactome: R-HSA-168928;Reactome: R-HSA-195253;Reactome: R-HSA-975956;Reactome: R-HSA-5696394;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-400253;Reactome: R-HSA-5684264;Reactome: R-HSA-9020702;Reactome: R-HSA-1253288;Reactome: R-HSA-9013973;Reactome: R-HSA-937039;Reactome: R-HSA-8866652;Reactome: R-HSA-205043;Reactome: R-HSA-6804756;Reactome: R-HSA-6804757;Reactome: R-HSA-156827;Reactome: R-HSA-180585;Reactome: R-HSA-8876493;Reactome: R-HSA-6791226;Reactome: R-HSA-2173788;Reactome: R-HSA-2173795;Reactome: R-HSA-5689603;Reactome: R-HSA-8951664;Reactome: R-HSA-72706;Reactome: R-HSA-5656169;Reactome: R-HSA-5607764;Reactome: R-HSA-5696397;Reactome: R-HSA-8854050;Reactome: R-HSA-3769402;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-202424;Reactome: R-HSA-174490;Reactome: R-HSA-6783310;Reactome: R-HSA-2559580;Reactome: R-HSA-5685942;Reactome: R-HSA-450321;Reactome: R-HSA-975110;Reactome: R-HSA-936964;Reactome: R-HSA-174184;Reactome: R-HSA-1295596;Reactome: R-HSA-209560;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-937072;Reactome: R-HSA-9013507;Reactome: R-HSA-72764;Reactome: R-HSA-2559585;Reactome: R-HSA-201681;Reactome: R-HSA-69481;Reactome: R-HSA-5357956;Reactome: R-HSA-1169091;Reactome: R-HSA-6782135;Reactome: R-HSA-8939902;Reactome: R-HSA-5675221;Reactome: R-HSA-917729;Reactome: R-HSA-5655862;Reactome: R-HSA-180534;Reactome: R-HSA-9633012;Reactome: R-HSA-1236382;Reactome: R-HSA-2173796;Reactome: R-HSA-5696395;Reactome: R-HSA-382556;Reactome: R-HSA-5357905;Reactome: R-HSA-5693607;Reactome: R-HSA-8948751;Reactome: R-HSA-9014325;Reactome: R-HSA-5675482;Reactome: R-HSA-5696400;Reactome: R-HSA-5205685;Reactome: R-HSA-9615710;Reactome: R-HSA-912631;Reactome: R-HSA-9604323;Reactome: R-HSA-209543;Reactome: R-HSA-5654733;Reactome: R-HSA-192823;Reactome: R-HSA-5693565;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-936440;Reactome: R-HSA-6804760;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-5689896;Reactome: R-HSA-9010553;Reactome: R-HSA-6782210;Reactome: R-HSA-168927;Reactome: R-HSA-917937;Reactome: R-HSA-983168;Reactome: R-HSA-1169408;Reactome: R-HSA-8856828;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-8866654;Reactome: R-HSA-5610783;Reactome: R-HSA-1799339;Reactome: R-HSA-937041;Reactome: R-HSA-9646399;Reactome: R-HSA-110320;Reactome: R-HSA-3134975;Reactome: R-HSA-174178;Reactome: R-HSA-72689;Reactome: R-HSA-179409;Reactome: R-HSA-5610780;Reactome: R-HSA-9637628;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-2691232;Reactome: R-HSA-68949;Reactome: R-HSA-110312;Reactome: R-HSA-975144;Reactome: R-HSA-8863795;Reactome: R-HSA-174048;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-2122947;Reactome: R-HSA-2871837;Reactome: R-HSA-69231;Reactome: R-HSA-168638;Reactome: R-HSA-2672351;Reactome: R-HSA-2979096;Reactome: R-HSA-901032;Reactome: R-HSA-937042;Reactome: R-HSA-8939236;Reactome: R-HSA-8856825;Reactome: R-HSA-5668541;Reactome: R-HSA-2559582;Reactome: R-HSA-3785653	"Regulation of RAS by GAPs";"ER-Phagosome pathway";"Josephin domain DUBs";"Peroxisomal protein import";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Stabilization of p53";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"APC/C:Cdc20 mediated degradation of Securin";"Formation of TC-NER Pre-Incision Complex";"Metalloprotease DUBs";"Negative regulation of FGFR2 signaling";"Budding and maturation of HIV virion";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Negative regulation of FGFR1 signaling";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"InlB-mediated entry of Listeria monocytogenes into host cell";"Asymmetric localization of PCP proteins";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Regulation of PTEN localization";"EGFR downregulation";"MAPK6/MAPK4 signaling";"Downregulation of ERBB2:ERBB3 signaling";"Negative regulation of MET activity";"Assembly Of The HIV Virion";"Degradation of DVL";"activated TAK1 mediates p38 MAPK activation";"Glycogen synthesis";"GLI3 is processed to GLI3R by the proteasome";"Peptide chain elongation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"Amyloid fiber formation";"Chaperone Mediated Autophagy";"Prevention of phagosomal-lysosomal fusion";"Activated NOTCH1 Transmits Signal to the Nucleus";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Regulation of PLK1 Activity at G2/M Transition";"Regulation of FZD by ubiquitination";"Negative regulation of FGFR3 signaling";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLI";"Alpha-protein kinase 1 signaling pathway";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Degradation of beta-catenin by the destruction complex";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"DNA Damage Recognition in GG-NER";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"Circadian Clock";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Interleukin-1 signaling";"Downregulation of ERBB4 signaling";"TICAM1-dependent activation of IRF3/IRF7";"IRAK1 recruits IKK complex";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"NRIF signals cell death from the nucleus";"Regulation of TP53 Activity through Phosphorylation";"Regulation of TP53 Degradation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Vif-mediated degradation of APOBEC3G";"InlA-mediated entry of Listeria monocytogenes into host cells";"Major pathway of rRNA processing in the nucleolus and cytosol";"Downregulation of TGF-beta receptor signaling";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"UCH proteinases";"Neddylation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Termination of translesion DNA synthesis";"CLEC7A (Dectin-1) signaling";"Gap-filling DNA repair synthesis and ligation in GG-NER";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Deactivation of the beta-catenin transactivating complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Downstream TCR signaling";"Membrane binding and targetting of GAG proteins";"Fanconi Anemia Pathway";"Oxidative Stress Induced Senescence";"HDR through Homologous Recombination (HRR)";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Spry regulation of FGF signaling";"NF-kB is activated and signals survival";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Eukaryotic Translation Termination";"Oncogene Induced Senescence";"TCF dependent signaling in response to WNT";"G2/M Checkpoints";"TNFR1-induced NFkappaB signaling pathway";"Activation of NF-kappaB in B cells";"Dual incision in TC-NER";"Regulation of RUNX2 expression and activity";"Negative regulation of MAPK pathway";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Translesion synthesis by POLK";"Vpu mediated degradation of CD4";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of Incision Complex in GG-NER";"ABC-family proteins mediated transport";"Regulation of TNFR1 signaling";"Processing of DNA double-strand break ends";"Regulation of PTEN stability and activity";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Regulation of necroptotic cell death";"Dual Incision in GG-NER";"Pink/Parkin Mediated Mitophagy";"Late endosomal microautophagy";"Regulation of signaling by CBL";"Negative regulation of NOTCH4 signaling";"p75NTR recruits signalling complexes";"Negative regulation of FGFR4 signaling";"Viral mRNA Translation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"Negative regulators of DDX58/IFIH1 signaling";"Regulation of TP53 Activity through Methylation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Ovarian tumor domain proteases";"Regulation of expression of SLITs and ROBOs";"Gap-filling DNA repair synthesis and ligation in TC-NER";"TICAM1, RIP1-mediated IKK complex recruitment";"Iron uptake and transport";"Antigen processing: Ubiquitination & Proteasome degradation";"ISG15 antiviral mechanism";"Clathrin-mediated endocytosis";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"E3 ubiquitin ligases ubiquitinate target proteins";"Degradation of GLI2 by the proteasome";"SRP-dependent cotranslational protein targeting to membrane";"IKK complex recruitment mediated by RIP1";"Aggrephagy";"Translesion Synthesis by POLH";"Regulation of innate immune responses to cytosolic DNA";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Formation of a pool of free 40S subunits";"APC-Cdc20 mediated degradation of Nek2A";"Degradation of GLI1 by the proteasome";"Modulation by Mtb of host immune system";"Degradation of AXIN";"Hedgehog ligand biogenesis";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Orc1 removal from chromatin";"Translesion synthesis by REV1";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Downregulation of ERBB2 signaling";"APC/C:Cdc20 mediated degradation of Cyclin B";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NOTCH1 Intracellular Domain Regulates Transcription";"FCERI mediated NF-kB activation";"Cyclin D associated events in G1";"NOD1/2 Signaling Pathway";"Stimuli-sensing channels";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"ER Quality Control Compartment (ERQC)";"IRAK2 mediated activation of TAK1 complex";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Cargo recognition for clathrin-mediated endocytosis";"TNFR2 non-canonical NF-kB pathway";"Senescence-Associated Secretory Phenotype (SASP)";"Myoclonic epilepsy of Lafora"
XP_053949835.1	4	Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
XP_053950417.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_053966816.1	7	MetaCyc: PWY-3561;Reactome: R-HSA-1483166;KEGG: 00564+3.1.4.4;KEGG: 00565+3.1.4.4;Reactome: R-HSA-2029485;MetaCyc: PWY-7039;Reactome: R-HSA-1483148	"Choline biosynthesis III";"Synthesis of PA";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Role of phospholipids in phagocytosis";"Phosphatidate metabolism, as a signaling molecule";"Synthesis of PG"
XP_053946261.1	24	Reactome: R-HSA-190840;Reactome: R-HSA-983189;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-6807878;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-8955332;Reactome: R-HSA-9648025;Reactome: R-HSA-1445148;Reactome: R-HSA-2132295;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-190861;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-380320;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399	"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Kinesins";"RHO GTPases Activate Formins";"Recycling pathway of L1";"COPI-mediated anterograde transport";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Carboxyterminal post-translational modifications of tubulin";"EML4 and NUDC in mitotic spindle formation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"MHC class II antigen presentation";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic";"HCMV Early Events";"RHO GTPases activate IQGAPs";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Gap junction assembly";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of NuMA to mitotic centrosomes";"Cilium Assembly";"Aggrephagy"
XP_053965472.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_053970138.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053946932.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053945522.1	10	Reactome: R-HSA-5368286;KEGG: 00620+1.2.4.1;Reactome: R-HSA-70268;Reactome: R-HSA-5419276;Reactome: R-HSA-204174;Reactome: R-HSA-389661;Reactome: R-HSA-5389840;KEGG: 00020+1.2.4.1;Reactome: R-HSA-5362517;KEGG: 00010+1.2.4.1	"Mitochondrial translation initiation";"Pyruvate metabolism";"Pyruvate metabolism";"Mitochondrial translation termination";"Regulation of pyruvate dehydrogenase (PDH) complex";"Glyoxylate metabolism and glycine degradation";"Mitochondrial translation elongation";"Citrate cycle (TCA cycle)";"Signaling by Retinoic Acid";"Glycolysis / Gluconeogenesis"
XP_053963954.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053948241.1	1	KEGG: 04150+2.7.11.24	"mTOR signaling pathway"
XP_053966484.1	9	Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-6804756	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Regulation of TP53 Activity through Phosphorylation"
XP_053951522.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053951529.1	3	Reactome: R-HSA-196757;KEGG: 00790+6.3.2.17;MetaCyc: PWY-2161	"Metabolism of folate and pterines";"Folate biosynthesis";"Folate polyglutamylation"
XP_053947644.1	1	Reactome: R-HSA-71262	"Carnitine synthesis"
XP_053952117.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-2206305;KEGG: 00531+3.1.6.14;Reactome: R-HSA-432720;Reactome: R-HSA-2022857	"Neutrophil degranulation";"MPS IIID - Sanfilippo syndrome D";"Glycosaminoglycan degradation";"Lysosome Vesicle Biogenesis";"Keratan sulfate degradation"
XP_053969269.1	6	Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107	"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_053956763.1	3	Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-75955	"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation"
XP_053951109.1	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
XP_053966865.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_053952233.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053951102.1	27	Reactome: R-HSA-159227;Reactome: R-HSA-112382;Reactome: R-HSA-159230;Reactome: R-HSA-159236;Reactome: R-HSA-72203;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-159231;Reactome: R-HSA-975956;Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-6807505;Reactome: R-HSA-167242;Reactome: R-HSA-6803529;Reactome: R-HSA-191859;Reactome: R-HSA-975957;Reactome: R-HSA-111367;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-72165;Reactome: R-HSA-9010553;Reactome: R-HSA-72187;Reactome: R-HSA-8851708;Reactome: R-HSA-77595	"Transport of the SLBP independent Mature mRNA";"Formation of RNA Pol II elongation complex";"Transport of the SLBP Dependant Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"mRNA Capping";"RNA polymerase II transcribes snRNA genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"FGFR2 alternative splicing";"snRNP Assembly";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SLBP independent Processing of Histone Pre-mRNAs";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"mRNA Splicing - Minor Pathway";"Regulation of expression of SLITs and ROBOs";"mRNA 3'-end processing";"Signaling by FGFR2 IIIa TM";"Processing of Intronless Pre-mRNAs"
XP_053949693.1	4	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway"
XP_053954864.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053954642.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1362409	"Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis"
XP_053951498.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053960571.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053945102.1	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
XP_053958532.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_053954603.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes"
XP_053945109.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_053957608.1	1	KEGG: 00240+3.1.3.89	"Pyrimidine metabolism"
XP_053961136.1	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
XP_053969957.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_053952169.1	3	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221;Reactome: R-HSA-420029	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Tight junction interactions"
XP_053966414.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053955532.1	15	Reactome: R-HSA-9664565;Reactome: R-HSA-9652282;Reactome: R-HSA-9665250;Reactome: R-HSA-9665251;Reactome: R-HSA-8863795;Reactome: R-HSA-5637810;Reactome: R-HSA-9634285;Reactome: R-HSA-9665246;Reactome: R-HSA-9665245;Reactome: R-HSA-9665247;Reactome: R-HSA-9665233;Reactome: R-HSA-1227986;Reactome: R-HSA-9665249;Reactome: R-HSA-1236382;Reactome: R-HSA-9665244	"Signaling by ERBB2 KD Mutants";"Drug-mediated inhibition of ERBB2 signaling";"Resistance of ERBB2 KD mutants to AEE788";"Resistance of ERBB2 KD mutants to lapatinib";"Downregulation of ERBB2 signaling";"Constitutive Signaling by EGFRvIII";"Constitutive Signaling by Overexpressed ERBB2";"Resistance of ERBB2 KD mutants to neratinib";"Resistance of ERBB2 KD mutants to tesevatinib";"Resistance of ERBB2 KD mutants to osimertinib";"Resistance of ERBB2 KD mutants to trastuzumab";"Signaling by ERBB2";"Resistance of ERBB2 KD mutants to afatinib";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Resistance of ERBB2 KD mutants to sapitinib"
XP_053967999.1	3	Reactome: R-HSA-5696394;Reactome: R-HSA-5689877;Reactome: R-HSA-5696395	"DNA Damage Recognition in GG-NER";"Josephin domain DUBs";"Formation of Incision Complex in GG-NER"
XP_053948102.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_053963284.1	16	Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-2467813;Reactome: R-HSA-176412;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-2559582;Reactome: R-HSA-174084;Reactome: R-HSA-174154;Reactome: R-HSA-174184	"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Separation of Sister Chromatids";"Phosphorylation of the APC/C";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
XP_053952748.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053956922.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_053955539.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
XP_053969650.1	27	Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-3301854;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-4615885;Reactome: R-HSA-180910;Reactome: R-HSA-159230;Reactome: R-HSA-159236;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-168325	"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"SUMOylation of DNA replication proteins";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP Dependant Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis"
XP_053963023.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053946080.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135	"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER"
XP_053957821.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053948529.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053958938.1	5	Reactome: R-HSA-209543;Reactome: R-HSA-5205685;Reactome: R-HSA-9020702;Reactome: R-HSA-205043;Reactome: R-HSA-209560	"p75NTR recruits signalling complexes";"Pink/Parkin Mediated Mitophagy";"Interleukin-1 signaling";"NRIF signals cell death from the nucleus";"NF-kB is activated and signals survival"
XP_053947970.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053969133.1	6	Reactome: R-HSA-4411364;Reactome: R-HSA-3769402;Reactome: R-HSA-8951430;Reactome: R-HSA-4086398;Reactome: R-HSA-4641265;Reactome: R-HSA-201722	"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex";"RUNX3 regulates WNT signaling";"Ca2+ pathway";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex"
XP_053946995.1	2	Reactome: R-HSA-8862803;Reactome: R-HSA-69273	"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Cyclin A/B1/B2 associated events during G2/M transition"
XP_053945220.1	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
XP_053946177.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053951241.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053960118.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053965413.1	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
XP_053958930.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_053966093.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053969568.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053954466.1	1	Reactome: R-HSA-2465910	"MASTL Facilitates Mitotic Progression"
XP_053949892.1	6	MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1;MetaCyc: PWY-7761;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807	"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
XP_053947394.1	4	Reactome: R-HSA-1660662;KEGG: 00600+3.5.1.23;MetaCyc: PWY-7119;MetaCyc: PWY-6483	"Glycosphingolipid metabolism";"Sphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)";"Ceramide degradation (generic)"
XP_053950396.1	1	Reactome: R-HSA-211897	"Cytochrome P450 - arranged by substrate type"
XP_053955082.1	5	Reactome: R-HSA-6804758;Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815	"Regulation of TP53 Activity through Acetylation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"Regulation of PTEN gene transcription";"HDACs deacetylate histones"
XP_053951164.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053967292.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053956744.1	13	MetaCyc: PWY-5133;KEGG: 00630+6.2.1.1;MetaCyc: PWY-7857;KEGG: 00010+6.2.1.1;MetaCyc: PWY-6672;MetaCyc: PWY-5108;KEGG: 00720+6.2.1.1;Reactome: R-HSA-71384;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5132;KEGG: 00640+6.2.1.1;MetaCyc: PWY-7118;KEGG: 00620+6.2.1.1	"Colupulone and cohumulone biosynthesis";"Glyoxylate and dicarboxylate metabolism";"Adlupulone and adhumulone biosynthesis";"Glycolysis / Gluconeogenesis";"Cis-genanyl-coa degradation";"L-isoleucine biosynthesis V";"Carbon fixation pathways in prokaryotes";"Ethanol oxidation";"Methane metabolism";"Lupulone and humulone biosynthesis";"Propanoate metabolism";"Chitin degradation to ethanol";"Pyruvate metabolism"
XP_053945228.1	4	Reactome: R-HSA-1650814;Reactome: R-HSA-2243919;Reactome: R-HSA-1474228;Reactome: R-HSA-2214320	"Collagen biosynthesis and modifying enzymes";"Crosslinking of collagen fibrils";"Degradation of the extracellular matrix";"Anchoring fibril formation"
XP_053957848.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053950431.1	13	KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7883;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101;KEGG: 00603+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;KEGG: 00513+3.2.1.52;KEGG: 00520+3.2.1.52	"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)";"Other glycan degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid metabolism";"CS/DS degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Various types of N-glycan biosynthesis";"Amino sugar and nucleotide sugar metabolism"
XP_053963984.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053954809.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912	"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane"
XP_053966886.1	3	Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621	"Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism"
XP_053946163.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053952721.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_053969723.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_053959825.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053951920.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053948490.1	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
XP_053946295.1	2	Reactome: R-HSA-5250971;Reactome: R-HSA-5682910	"Toxicity of botulinum toxin type C (BoNT/C)";"LGI-ADAM interactions"
XP_053958019.1	4	KEGG: 00230+6.3.5.2;MetaCyc: PWY-7221;Reactome: R-HSA-73817;KEGG: 00983+6.3.5.2	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Drug metabolism - other enzymes"
XP_053953999.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053950806.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053952740.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053965453.1	13	MetaCyc: PWY-7721;MetaCyc: PWY-6859;MetaCyc: PWY-6383;MetaCyc: PWY-5122;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-5123;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-7182;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-7709	"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Linalool biosynthesis I";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"(3R)-linalool biosynthesis"
XP_053952078.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_053962450.1	56	Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-69481;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-450408;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4641258;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-9604323;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-174184	"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"G2/M Checkpoints";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of DVL";"Degradation of AXIN";"Hedgehog ligand biogenesis";"Negative regulation of NOTCH4 signaling";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Neddylation";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
XP_053961323.1	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
XP_053946530.1	4	KEGG: 00513+2.4.1.260;Reactome: R-HSA-446193;Reactome: R-HSA-4720489;KEGG: 00510+2.4.1.260	"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG12 causes ALG12-CDG (CDG-1g)";"N-Glycan biosynthesis"
XP_053966226.1	10	Reactome: R-HSA-2160916;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2024096;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;Reactome: R-HSA-6798695;KEGG: 00600+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2206292	"Hyaluronan uptake and degradation";"Glycosphingolipid biosynthesis - ganglio series";"HS-GAG degradation";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"Neutrophil degranulation";"Sphingolipid metabolism";"Galactose metabolism";"Other glycan degradation";"MPS VII - Sly syndrome"
XP_053962300.1	3	Reactome: R-HSA-5689880;Reactome: R-HSA-110314;Reactome: R-HSA-6783310	"Ub-specific processing proteases";"Recognition of DNA damage by PCNA-containing replication complex";"Fanconi Anemia Pathway"
XP_053965303.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053959285.1	22	Reactome: R-HSA-432142;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-5663220;Reactome: R-HSA-195253;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-68877;Reactome: R-HSA-5358751;Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-6811558;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-2500257;Reactome: R-HSA-5673000;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-196299	"Platelet sensitization by LDL";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"RHO GTPases Activate Formins";"Degradation of beta-catenin by the destruction complex";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"RAF activation";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Beta-catenin phosphorylation cascade"
XP_053956071.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053966357.1	3	MetaCyc: PWY-6689;MetaCyc: PWY-7803;Reactome: R-HSA-6784531	"Trna splicing I";"Trna splicing II";"tRNA processing in the nucleus"
XP_053951244.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053958476.1	6	Reactome: R-HSA-8863795;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-8948751;Reactome: R-HSA-2173788	"Downregulation of ERBB2 signaling";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Regulation of PTEN stability and activity";"Downregulation of TGF-beta receptor signaling"
XP_053957824.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_053953790.1	14	MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.51;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51	"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PA";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism"
XP_053947497.1	10	KEGG: 05163+2.7.1.153;MetaCyc: PWY-6352;Reactome: R-HSA-1660499;KEGG: 04151+2.7.1.153;KEGG: 04070+2.7.1.153;KEGG: 00562+2.7.1.153;KEGG: 05165+2.7.1.153;Reactome: R-HSA-9027276;KEGG: 04150+2.7.1.153;KEGG: 05170+2.7.1.153	"Human cytomegalovirus infection";"3-phosphoinositide biosynthesis";"Synthesis of PIPs at the plasma membrane";"PI3K-Akt signaling pathway";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Human papillomavirus infection";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053967205.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053945729.1	14	MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;Reactome: R-HSA-75876;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7725;MetaCyc: PWY-8041	"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis"
XP_053945244.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_053952949.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053952903.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053964462.1	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
XP_053969901.1	1	Reactome: R-HSA-5419276	"Mitochondrial translation termination"
XP_053945722.1	14	MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-8041	"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis"
XP_053947783.1	1	Reactome: R-HSA-912446	"Meiotic recombination"
XP_053960843.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053960809.1	9	Reactome: R-HSA-8849932;Reactome: R-HSA-5673001;Reactome: R-HSA-6794361;Reactome: R-HSA-438066;Reactome: R-HSA-9620244;Reactome: R-HSA-9609736;Reactome: R-HSA-3928662;Reactome: R-HSA-442982;Reactome: R-HSA-9617324	"Synaptic adhesion-like molecules";"RAF/MAP kinase cascade";"Neurexins and neuroligins";"Unblocking of NMDA receptors, glutamate binding and activation";"Long-term potentiation";"Assembly and cell surface presentation of NMDA receptors";"EPHB-mediated forward signaling";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission"
XP_053957630.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053963996.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053968016.1	2	Reactome: R-HSA-201722;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex"
XP_053951888.1	8	KEGG: 04926+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Activation of RAC1";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053963113.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053958732.1	5	MetaCyc: PWY-6906;Reactome: R-HSA-70171;MetaCyc: PWY-6855;MetaCyc: PWY-5514;KEGG: 00520+3.5.99.6	"Chitin derivatives degradation";"Glycolysis";"Chitin degradation I (archaea)";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Amino sugar and nucleotide sugar metabolism"
XP_053950384.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053955208.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053959098.1	10	Reactome: R-HSA-5689880;Reactome: R-HSA-182971;Reactome: R-HSA-9635644;Reactome: R-HSA-432720;Reactome: R-HSA-917729;Reactome: R-HSA-6807004;Reactome: R-HSA-8875360;Reactome: R-HSA-9636383;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Ub-specific processing proteases";"EGFR downregulation";"Inhibition of membrane repair";"Lysosome Vesicle Biogenesis";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Negative regulation of MET activity";"InlB-mediated entry of Listeria monocytogenes into host cell";"Prevention of phagosomal-lysosomal fusion";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053964396.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053946202.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053960466.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053966317.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_053966926.1	2	Reactome: R-HSA-5619039;Reactome: R-HSA-426117	"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)";"Cation-coupled Chloride cotransporters"
XP_053958509.1	8	Reactome: R-HSA-68827;Reactome: R-HSA-68867;Reactome: R-HSA-113507;Reactome: R-HSA-68962;Reactome: R-HSA-68616;Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-68689	"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex"
XP_053957281.1	8	Reactome: R-HSA-5683826;MetaCyc: PWY-7179-1;MetaCyc: PWY-7179;Reactome: R-HSA-74217;Reactome: R-HSA-6798695;KEGG: 00230+3.5.4.4;MetaCyc: PWY-6609;MetaCyc: PWY-6611	"Surfactant metabolism";"Purine deoxyribonucleosides degradation II";"Purine deoxyribonucleosides degradation I";"Purine salvage";"Neutrophil degranulation";"Purine metabolism";"Adenine and adenosine salvage III";"Adenine and adenosine salvage V"
XP_053962155.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053948670.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053957638.1	14	Reactome: R-HSA-75896;MetaCyc: PWY-8053;MetaCyc: PWY-5667;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;KEGG: 00564+2.3.1.15;MetaCyc: PWY-6453;KEGG: 00561+2.3.1.15;MetaCyc: PWY-8051;MetaCyc: PWY-8055;Reactome: R-HSA-9033241;MetaCyc: PWY-7587;KEGG: 00564+2.3.1.42	"Plasmalogen biosynthesis";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Plasmalogen biosynthesis";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis";"Glycerolipid metabolism";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Peroxisomal protein import";"Oleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism"
XP_053959985.1	3	MetaCyc: PWY-5691;KEGG: 00232+1.7.3.3;KEGG: 00230+1.7.3.3	"Urate conversion to allantoin I";"Caffeine metabolism";"Purine metabolism"
XP_053958502.1	40	Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-72165;Reactome: R-HSA-5617472;Reactome: R-HSA-75953;Reactome: R-HSA-6803529;Reactome: R-HSA-167242;Reactome: R-HSA-168325;Reactome: R-HSA-6807505;Reactome: R-HSA-167246;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-72163;Reactome: R-HSA-203927;Reactome: R-HSA-6781823;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-167287;Reactome: R-HSA-77075;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-5578749;Reactome: R-HSA-167172;Reactome: R-HSA-72203;Reactome: R-HSA-73779;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-5601884	"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Minor Pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase II Transcription Initiation";"FGFR2 alternative splicing";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Viral Messenger RNA Synthesis";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Promoter Escape";"mRNA Capping";"mRNA Splicing - Major Pathway";"MicroRNA (miRNA) biogenesis";"Formation of TC-NER Pre-Incision Complex";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"HIV elongation arrest and recovery";"RNA Pol II CTD phosphorylation and interaction with CE";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Transcriptional regulation by small RNAs";"Transcription of the HIV genome";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"PIWI-interacting RNA (piRNA) biogenesis"
XP_053963630.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053952249.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053952724.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053948977.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053952203.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling"
XP_053951139.1	13	KEGG: 00720+4.2.1.2;MetaCyc: PWY-5690;MetaCyc: PWY-6969;MetaCyc: PWY-5392;MetaCyc: PWY-561;KEGG: 00620+4.2.1.2;MetaCyc: PWY-8086;MetaCyc: PWY-7384;MetaCyc: PWY-7254;MetaCyc: PWY-5913;KEGG: 00020+4.2.1.2;Reactome: R-HSA-71403;MetaCyc: PWY-6728	"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"Superpathway of glyoxylate cycle and fatty acid degradation";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle VII (acetate-producers)";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle"
XP_053962898.1	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
XP_053963937.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053954150.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053951161.1	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
XP_053947436.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053962308.1	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053963981.1	2	Reactome: R-HSA-2408508;Reactome: R-HSA-389661	"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Glyoxylate metabolism and glycine degradation"
XP_053950434.1	13	Reactome: R-HSA-1660662;Reactome: R-HSA-2024101;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916	"Glycosphingolipid metabolism";"CS/DS degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Hyaluronan uptake and degradation"
XP_053947391.1	3	MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2;Reactome: R-HSA-1650814	"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism";"Collagen biosynthesis and modifying enzymes"
XP_053946902.1	6	KEGG: 00260+5.4.2.11;MetaCyc: PWY-5484;KEGG: 00010+5.4.2.11;MetaCyc: PWY-1622;MetaCyc: PWY-8004;KEGG: 00680+5.4.2.11	"Glycine, serine and threonine metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation I (serine pathway)";"Entner-Doudoroff pathway I";"Methane metabolism"
XP_053964381.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (q) signalling events";"Peptide ligand-binding receptors"
XP_053946909.1	14	Reactome: R-HSA-1474228;Reactome: R-HSA-9017802;Reactome: R-HSA-193692;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700;Reactome: R-HSA-3928665;Reactome: R-HSA-205043;Reactome: R-HSA-6798695;Reactome: R-HSA-2644606;Reactome: R-HSA-977225;Reactome: R-HSA-2894862	"Degradation of the extracellular matrix";"Noncanonical activation of NOTCH3";"Regulated proteolysis of p75NTR";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"EPH-ephrin mediated repulsion of cells";"NRIF signals cell death from the nucleus";"Neutrophil degranulation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Amyloid fiber formation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053945161.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_053953798.1	14	KEGG: 00561+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-5981;MetaCyc: PWY-6453;MetaCyc: PWY-7589;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8053;MetaCyc: PWY-5667;MetaCyc: PWY-7417	"Glycerolipid metabolism";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Plasmalogen biosynthesis";"CDP-diacylglycerol biosynthesis III";"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)"
XP_053968699.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053954747.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053960649.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053945810.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053964457.1	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
XP_053947628.1	26	Reactome: R-HSA-6807878;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-389977;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-190861;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-9609736;Reactome: R-HSA-389960;Reactome: R-HSA-190840;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-8955332;Reactome: R-HSA-2132295;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434;Reactome: R-HSA-5626467	"COPI-mediated anterograde transport";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Post-chaperonin tubulin folding pathway";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Gap junction assembly";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"Assembly and cell surface presentation of NMDA receptors";"Formation of tubulin folding intermediates by CCT/TriC";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Aggrephagy";"Cilium Assembly";"Carboxyterminal post-translational modifications of tubulin";"MHC class II antigen presentation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs"
XP_053966387.1	9	Reactome: R-HSA-196780;MetaCyc: PWY-8086;Reactome: R-HSA-70263;Reactome: R-HSA-3371599;KEGG: 00020+6.4.1.1;MetaCyc: PWY-6146;KEGG: 00720+6.4.1.1;MetaCyc: PWY-6142;KEGG: 00620+6.4.1.1	"Biotin transport and metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis";"Defective HLCS causes multiple carboxylase deficiency";"Citrate cycle (TCA cycle)";"Methanobacterium thermoautotrophicum biosynthetic metabolism";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pyruvate metabolism"
XP_053946128.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053957211.1	3	Reactome: R-HSA-193681;Reactome: R-HSA-1660662;Reactome: R-HSA-5626978	"Ceramide signalling";"Glycosphingolipid metabolism";"TNFR1-mediated ceramide production"
XP_053957183.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053955847.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053964404.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_053949645.1	11	Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-163359;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555	"PKA activation in glucagon signalling";"Hedgehog 'off' state";"G alpha (i) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon signaling in metabolic regulation";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"G alpha (s) signalling events"
XP_053956852.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053945858.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
XP_053956405.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053969523.1	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
XP_053963251.1	3	Reactome: R-HSA-4419969;Reactome: R-HSA-2995383;Reactome: R-HSA-2980766	"Depolymerisation of the Nuclear Lamina";"Initiation of Nuclear Envelope Reformation";"Nuclear Envelope Breakdown"
XP_053955684.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_053950836.1	7	Reactome: R-HSA-2691232;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2660826	"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant"
XP_053945850.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053945678.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053963426.1	10	Reactome: R-HSA-9627069;Reactome: R-HSA-111463;Reactome: R-HSA-611105;Reactome: R-HSA-3299685;Reactome: R-HSA-5628897;Reactome: R-HSA-2151201;Reactome: R-HSA-111458;Reactome: R-HSA-111459;Reactome: R-HSA-111464;Reactome: R-HSA-111457	"Regulation of the apoptosome activity";"SMAC (DIABLO) binds to IAPs";"Respiratory electron transport";"Detoxification of Reactive Oxygen Species";"TP53 Regulates Metabolic Genes";"Transcriptional activation of mitochondrial biogenesis";"Formation of apoptosome";"Activation of caspases through apoptosome-mediated cleavage";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Release of apoptotic factors from the mitochondria"
XP_053952027.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053958795.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053954861.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053957911.1	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
XP_053958208.1	11	MetaCyc: PWY-8055;MetaCyc: PWY-8052;MetaCyc: PWY-8053;MetaCyc: PWY-8051;Reactome: R-HSA-2029485;KEGG: 00561+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;MetaCyc: PWY-6453;KEGG: 00564+3.1.3.4;KEGG: 00565+3.1.3.4	"Palmitoyl ethanolamide biosynthesis";"2-arachidonoylglycerol biosynthesis";"Anandamide biosynthesis II";"Anandamide biosynthesis I";"Role of phospholipids in phagocytosis";"Glycerolipid metabolism";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Ether lipid metabolism"
XP_053955476.1	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
XP_053947927.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053956812.1	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
XP_053954832.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053947316.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_053960335.1	10	Reactome: R-HSA-73776;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-3214847;Reactome: R-HSA-75953;Reactome: R-HSA-6804756	"RNA Polymerase II Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"HATs acetylate histones";"RNA Polymerase II Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation"
XP_053945818.1	7	Reactome: R-HSA-5632684;Reactome: R-HSA-5632681;Reactome: R-HSA-5362798;Reactome: R-HSA-5658034;Reactome: R-HSA-5358346;Reactome: R-HSA-5635838;Reactome: R-HSA-373080	"Hedgehog 'on' state";"Ligand-receptor interactions";"Release of Hh-Np from the secreting cell";"HHAT G278V abrogates palmitoylation of Hh-Np";"Hedgehog ligand biogenesis";"Activation of SMO";"Class B/2 (Secretin family receptors)"
XP_053946141.1	7	Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912	"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane"
XP_053951277.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_053958607.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053950401.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053961360.1	24	Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-422356;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-8853659;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-381676;Reactome: R-HSA-5610783;Reactome: R-HSA-163560;Reactome: R-HSA-4420097;Reactome: R-HSA-392517;KEGG: 04150+2.7.11.11;Reactome: R-HSA-163358;Reactome: R-HSA-163615;Reactome: R-HSA-111931;Reactome: R-HSA-983231;Reactome: R-HSA-8963896;Reactome: R-HSA-5610785;Reactome: R-HSA-9634600;Reactome: R-HSA-180024;Reactome: R-HSA-5621575;Reactome: R-HSA-9010642	"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"Regulation of insulin secretion";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"RET signaling";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Degradation of GLI2 by the proteasome";"Triglyceride catabolism";"VEGFA-VEGFR2 Pathway";"Rap1 signalling";"mTOR signaling pathway";"PKA-mediated phosphorylation of key metabolic factors";"PKA activation";"PKA-mediated phosphorylation of CREB";"Factors involved in megakaryocyte development and platelet production";"HDL assembly";"GLI3 is processed to GLI3R by the proteasome";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"DARPP-32 events";"CD209 (DC-SIGN) signaling";"ROBO receptors bind AKAP5"
XP_053949361.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053946120.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053948244.1	5	Reactome: R-HSA-1679131;Reactome: R-HSA-1442490;Reactome: R-HSA-6798695;Reactome: R-HSA-2022090;Reactome: R-HSA-2132295	"Trafficking and processing of endosomal TLR";"Collagen degradation";"Neutrophil degranulation";"Assembly of collagen fibrils and other multimeric structures";"MHC class II antigen presentation"
XP_053948729.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_053948321.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053959524.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053954586.1	8	Reactome: R-HSA-69183;Reactome: R-HSA-68962;Reactome: R-HSA-69091;Reactome: R-HSA-174430;Reactome: R-HSA-69166;Reactome: R-HSA-113501;Reactome: R-HSA-174411;Reactome: R-HSA-68952	"Processive synthesis on the lagging strand";"Activation of the pre-replicative complex";"Polymerase switching";"Telomere C-strand synthesis initiation";"Removal of the Flap Intermediate";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Polymerase switching on the C-strand of the telomere";"DNA replication initiation"
XP_053957192.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053955369.1	1	Reactome: R-HSA-4419969	"Depolymerisation of the Nuclear Lamina"
XP_053949762.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_053957199.1	4	Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-5689880;Reactome: R-HSA-111465	"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"Ub-specific processing proteases";"Apoptotic cleavage of cellular proteins"
XP_053945698.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053946368.1	4	Reactome: R-HSA-112311;KEGG: 00564+3.1.1.7;Reactome: R-HSA-1483191;Reactome: R-HSA-422085	"Neurotransmitter clearance";"Glycerophospholipid metabolism";"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin"
XP_053949493.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053950950.1	2	KEGG: 00970+6.1.1.11;MetaCyc: PWY-6281	"Aminoacyl-tRNA biosynthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)"
XP_053965544.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053961128.1	6	Reactome: R-HSA-1474151;MetaCyc: PWY-6983;MetaCyc: PWY-5663;KEGG: 00790+4.2.3.12;MetaCyc: PWY-7442;MetaCyc: PWY-5664	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Threo-tetrahydrobiopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis II"
XP_053964759.1	7	KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053951936.1	9	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-198323;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"AKT phosphorylates targets in the cytosol";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"Relaxin signaling pathway"
XP_053958451.1	11	MetaCyc: PWY-6964;KEGG: 00630+6.3.1.2;MetaCyc: PWY-5675;Reactome: R-HSA-210455;KEGG: 00250+6.3.1.2;MetaCyc: PWY-381;MetaCyc: PWY-6963;KEGG: 00220+6.3.1.2;MetaCyc: PWY-6549;Reactome: R-HSA-8964539;KEGG: 00910+6.3.1.2	"Ammonia assimilation cycle II";"Glyoxylate and dicarboxylate metabolism";"Nitrate reduction V (assimilatory)";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Alanine, aspartate and glutamate metabolism";"Nitrate reduction II (assimilatory)";"Ammonia assimilation cycle I";"Arginine biosynthesis";"L-glutamine biosynthesis III";"Glutamate and glutamine metabolism";"Nitrogen metabolism"
XP_053950657.1	2	Reactome: R-HSA-71336;KEGG: 00030+2.7.1.15	"Pentose phosphate pathway";"Pentose phosphate pathway"
XP_053954442.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053958775.1	3	Reactome: R-HSA-8876725;KEGG: 00310+2.1.1.60;Reactome: R-HSA-2514859	"Protein methylation";"Lysine degradation";"Inactivation, recovery and regulation of the phototransduction cascade"
XP_053964752.1	3	Reactome: R-HSA-418597;Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13	"G alpha (z) signalling events";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_053963400.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053949148.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-375276	"G alpha (i) signalling events";"Peptide ligand-binding receptors"
XP_053954685.1	7	Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-73780	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation"
XP_053950567.1	1	Reactome: R-HSA-9018519	"Estrogen-dependent gene expression"
XP_053961730.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053967184.1	7	MetaCyc: PWY-5921;Reactome: R-HSA-210500;Reactome: R-HSA-5628897;KEGG: 00471+3.5.1.2;Reactome: R-HSA-8964539;KEGG: 00250+3.5.1.2;KEGG: 00220+3.5.1.2	"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate Neurotransmitter Release Cycle";"TP53 Regulates Metabolic Genes";"D-Glutamine and D-glutamate metabolism";"Glutamate and glutamine metabolism";"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis"
XP_053950863.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_053950446.1	13	KEGG: 04926+2.7.11.1;Reactome: R-HSA-3928662;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5627117;Reactome: R-HSA-416572;Reactome: R-HSA-3928663;KEGG: 05163+2.7.11.1;Reactome: R-HSA-4420097;Reactome: R-HSA-416482;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"EPHB-mediated forward signaling";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"RHO GTPases Activate ROCKs";"Sema4D induced cell migration and growth-cone collapse";"EPHA-mediated growth cone collapse";"Human cytomegalovirus infection";"VEGFA-VEGFR2 Pathway";"G alpha (12/13) signalling events";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053960756.1	7	Reactome: R-HSA-446193;KEGG: 00510+2.7.8.15;MetaCyc: PWY-6470;MetaCyc: PWY-5265;Reactome: R-HSA-4549356;KEGG: 00550+2.7.8.13;MetaCyc: PWY-6471	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis II (staphylococci)";"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2";"Peptidoglycan biosynthesis";"Peptidoglycan biosynthesis IV (Enterococcus faecium)"
XP_053947444.1	10	MetaCyc: PWY-7003;MetaCyc: PWY-5484;Reactome: R-HSA-70171;KEGG: 00051+5.3.1.1;KEGG: 00010+5.3.1.1;Reactome: R-HSA-70263;MetaCyc: PWY-1042;KEGG: 00710+5.3.1.1;MetaCyc: PWY-6142;KEGG: 00562+5.3.1.1	"Glycerol degradation to butanol";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Inositol phosphate metabolism"
XP_053966509.1	4	Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823	"Dual Incision in GG-NER";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex"
XP_053950910.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053945236.1	4	Reactome: R-HSA-1650814;Reactome: R-HSA-2243919;Reactome: R-HSA-2214320;Reactome: R-HSA-1474228	"Collagen biosynthesis and modifying enzymes";"Crosslinking of collagen fibrils";"Anchoring fibril formation";"Degradation of the extracellular matrix"
XP_053954591.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_053964712.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053962287.1	5	Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-75035;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897	"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes"
XP_053962262.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053966739.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_053965672.1	3	Reactome: R-HSA-3899300;Reactome: R-HSA-4090294;Reactome: R-HSA-3232118	"SUMOylation of transcription cofactors";"SUMOylation of intracellular receptors";"SUMOylation of transcription factors"
XP_053958411.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053949501.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053950617.1	3	Reactome: R-HSA-8963693;KEGG: 00460+3.5.1.1;KEGG: 00250+3.5.1.1	"Aspartate and asparagine metabolism";"Cyanoamino acid metabolism";"Alanine, aspartate and glutamate metabolism"
XP_053949014.1	27	Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-191859	"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly"
XP_053948427.1	2	Reactome: R-HSA-5633231;Reactome: R-HSA-446193	"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
XP_053958894.1	5	Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389957	"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053951997.1	2	Reactome: R-HSA-444821;Reactome: R-HSA-418555	"Relaxin receptors";"G alpha (s) signalling events"
XP_053962688.1	4	Reactome: R-HSA-6802952;Reactome: R-HSA-6798695;Reactome: R-HSA-1632852;Reactome: R-HSA-983168	"Signaling by BRAF and RAF fusions";"Neutrophil degranulation";"Macroautophagy";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053945690.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-163282	"Transcriptional activation of mitochondrial biogenesis";"Mitochondrial transcription initiation"
XP_053962231.1	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
XP_053966761.1	6	Reactome: R-HSA-428930;Reactome: R-HSA-399997;Reactome: R-HSA-456926;Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-418592	"Thromboxane signalling through TP receptor";"Acetylcholine regulates insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1"
XP_053957400.1	13	Reactome: R-HSA-167590;Reactome: R-HSA-437239;Reactome: R-HSA-177504;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-2132295;Reactome: R-HSA-182218;Reactome: R-HSA-5099900;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-8866427;Reactome: R-HSA-8964038;Reactome: R-HSA-5140745	"Nef Mediated CD4 Down-regulation";"Recycling pathway of L1";"Retrograde neurotrophin signalling";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation";"WNT5A-dependent internalization of FZD4";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"VLDLR internalisation and degradation";"LDL clearance";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2"
XP_053966476.1	7	MetaCyc: PWY-5941;Reactome: R-HSA-70221;MetaCyc: PWY-6737;Reactome: R-HSA-6798695;MetaCyc: PWY-7238;KEGG: 00500+2.4.1.25;MetaCyc: PWY-6724	"Glycogen degradation II";"Glycogen breakdown (glycogenolysis)";"Starch degradation V";"Neutrophil degranulation";"Sucrose biosynthesis II";"Starch and sucrose metabolism";"Starch degradation II"
XP_053958226.1	2	Reactome: R-HSA-1483152;Reactome: R-HSA-1483115	"Hydrolysis of LPE";"Hydrolysis of LPC"
XP_053958481.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053959162.1	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
XP_053962957.1	3	MetaCyc: PWY-7420;Reactome: R-HSA-426048;KEGG: 00561+3.1.1.23	"Monoacylglycerol metabolism (yeast)";"Arachidonate production from DAG";"Glycerolipid metabolism"
XP_053947792.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_053969025.1	5	Reactome: R-HSA-110329;Reactome: R-HSA-3108214;Reactome: R-HSA-110357;Reactome: R-HSA-110328;Reactome: R-HSA-5221030	"Cleavage of the damaged pyrimidine";"SUMOylation of DNA damage response and repair proteins";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"TET1,2,3 and TDG demethylate DNA"
XP_053960383.1	3	Reactome: R-HSA-2514859;MetaCyc: PWY-7800;MetaCyc: PWY-7799	"Inactivation, recovery and regulation of the phototransduction cascade";"Ac/N-end rule pathway";"Arg/N-end rule pathway (eukaryotic)"
XP_053965728.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053950669.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053964782.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053955894.1	8	MetaCyc: PWY-5394;KEGG: 00790+1.14.16.2;MetaCyc: PWY-5049;KEGG: 00950+1.14.16.2;MetaCyc: PWY-6133;MetaCyc: PWY-3581;Reactome: R-HSA-209905;KEGG: 00350+1.14.16.2	"Betalamic acid biosynthesis";"Folate biosynthesis";"Rosmarinic acid biosynthesis II";"Isoquinoline alkaloid biosynthesis";"(S)-reticuline biosynthesis II";"(S)-reticuline biosynthesis I";"Catecholamine biosynthesis";"Tyrosine metabolism"
XP_053951427.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053948997.1	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053965653.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053966607.1	4	KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193	"Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I"
XP_053967107.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053962650.1	20	KEGG: 00720+2.3.3.8;MetaCyc: PWY-6969;MetaCyc: PWY-5392;KEGG: 00720+6.2.1.5;Reactome: R-HSA-75105;MetaCyc: PWY-5690;MetaCyc: PWY-5537;MetaCyc: PWY-5172;MetaCyc: PWY-5913;Reactome: R-HSA-6798695;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-7384;Reactome: R-HSA-1268020;KEGG: 00660+6.2.1.5;KEGG: 00020+2.3.3.8;Reactome: R-HSA-163765;KEGG: 00020+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5538	"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"Fatty acyl-CoA biosynthesis";"TCA cycle II (plants and fungi)";"Pyruvate fermentation to acetate V";"Acetyl-coa biosynthesis III (from citrate)";"Partial TCA cycle (obligate autotrophs)";"Neutrophil degranulation";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Mitochondrial protein import";"C5-Branched dibasic acid metabolism";"Citrate cycle (TCA cycle)";"ChREBP activates metabolic gene expression";"Citrate cycle (TCA cycle)";"Propanoate metabolism";"Pyruvate fermentation to acetate VI"
XP_053965889.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053966795.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053963276.1	5	MetaCyc: PWY-7180;KEGG: 00030+4.1.2.4;Reactome: R-HSA-71336;MetaCyc: PWY-8060;Reactome: R-HSA-6798695	"2-deoxy-alpha-D-ribose 1-phosphate degradation";"Pentose phosphate pathway";"Pentose phosphate pathway";"2-deoxy-D-ribose degradation I";"Neutrophil degranulation"
XP_053954666.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053965882.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053965867.1	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
XP_053962904.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_053947371.1	4	MetaCyc: PWY-7382;Reactome: R-HSA-389661;KEGG: 00785+2.3.1.181;MetaCyc: PWY-6987	"Lipoate biosynthesis and incorporation IV (yeast)";"Glyoxylate metabolism and glycine degradation";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation III (Bacillus)"
XP_053967154.1	10	MetaCyc: PWY-922;MetaCyc: PWY-7571;KEGG: 00650+2.3.3.10;KEGG: 00280+2.3.3.10;Reactome: R-HSA-1989781;KEGG: 00072+2.3.3.10;MetaCyc: PWY-7524;MetaCyc: PWY-7391;KEGG: 00900+2.3.3.10;MetaCyc: PWY-6174	"Mevalonate pathway I";"Ferrichrome A biosynthesis";"Butanoate metabolism";"Valine, leucine and isoleucine degradation";"PPARA activates gene expression";"Synthesis and degradation of ketone bodies";"Mevalonate pathway III (archaea)";"Isoprene biosynthesis II (engineered)";"Terpenoid backbone biosynthesis";"Mevalonate pathway II (archaea)"
XP_053968672.1	4	Reactome: R-HSA-983231;Reactome: R-HSA-1170546;Reactome: R-HSA-2586552;Reactome: R-HSA-982772	"Factors involved in megakaryocyte development and platelet production";"Prolactin receptor signaling";"Signaling by Leptin";"Growth hormone receptor signaling"
XP_053964002.1	7	Reactome: R-HSA-5620922;Reactome: R-HSA-6798695;Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389957	"BBSome-mediated cargo-targeting to cilium";"Neutrophil degranulation";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053954655.1	2	Reactome: R-HSA-1483152;Reactome: R-HSA-1483115	"Hydrolysis of LPE";"Hydrolysis of LPC"
XP_053956706.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053949704.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_053959131.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_053968679.1	4	Reactome: R-HSA-2586552;Reactome: R-HSA-1170546;Reactome: R-HSA-983231;Reactome: R-HSA-982772	"Signaling by Leptin";"Prolactin receptor signaling";"Factors involved in megakaryocyte development and platelet production";"Growth hormone receptor signaling"
XP_053964009.1	3	Reactome: R-HSA-6804760;Reactome: R-HSA-191859;Reactome: R-HSA-3214858	"Regulation of TP53 Activity through Methylation";"snRNP Assembly";"RMTs methylate histone arginines"
XP_053950559.1	6	Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-380994	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress"
XP_053953778.1	2	KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386	"Pyruvate metabolism";"Methylglyoxal degradation I"
XP_053961202.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_053964043.1	2	Reactome: R-HSA-8875656;Reactome: R-HSA-8873719	"MET receptor recycling";"RAB geranylgeranylation"
XP_053963725.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_053962257.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_053956091.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053962917.1	6	MetaCyc: PWY-5723;Reactome: R-HSA-71336;KEGG: 00710+5.1.3.1;KEGG: 00040+5.1.3.1;KEGG: 00030+5.1.3.1;MetaCyc: PWY-1861	"Rubisco shunt";"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"Pentose and glucuronate interconversions";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)"
XP_053953770.1	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
XP_053947477.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_053960372.1	42	Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-5334118;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-3214858;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-2559580;Reactome: R-HSA-912446;Reactome: R-HSA-9018519;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-110331;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-5693607;Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-427413;Reactome: R-HSA-3214842;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-2299718;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638	"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"DNA methylation";"Packaging Of Telomere Ends";"Meiotic synapsis";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"RMTs methylate histone arginines";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"Oxidative Stress Induced Senescence";"Meiotic recombination";"Estrogen-dependent gene expression";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Cleavage of the damaged purine";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Processing of DNA double-strand break ends";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"HDMs demethylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"Condensation of Prophase Chromosomes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"HCMV Late Events";"SUMOylation of chromatin organization proteins"
XP_053948297.1	34	Reactome: R-HSA-75953;Reactome: R-HSA-69656;Reactome: R-HSA-5696395;Reactome: R-HSA-8939236;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-69231;Reactome: R-HSA-167162;Reactome: R-HSA-73762;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-75955;Reactome: R-HSA-427413;Reactome: R-HSA-76042;Reactome: R-HSA-69202;Reactome: R-HSA-167152;Reactome: R-HSA-77075;Reactome: R-HSA-167160;Reactome: R-HSA-72086;Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-6781823;Reactome: R-HSA-113418;Reactome: R-HSA-73772;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-69273;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-167172	"RNA Polymerase II Transcription Initiation";"Cyclin A:Cdk2-associated events at S phase entry";"Formation of Incision Complex in GG-NER";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"Cyclin D associated events in G1";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"RNA Polymerase II Transcription Elongation";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Cyclin E associated events during G1/S transition";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"mRNA Capping";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Formation of the Early Elongation Complex";"RNA Polymerase I Promoter Escape";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"Cyclin A/B1/B2 associated events during G2/M transition";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome"
XP_053962610.1	8	KEGG: 00520+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00524+2.7.1.1;Reactome: R-HSA-70171	"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Neomycin, kanamycin and gentamicin biosynthesis";"Glycolysis"
XP_053966874.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053953154.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053949534.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053960379.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053954516.1	1	Reactome: R-HSA-2468052	"Establishment of Sister Chromatid Cohesion"
XP_053966908.1	2	Reactome: R-HSA-1483115;Reactome: R-HSA-1483152	"Hydrolysis of LPC";"Hydrolysis of LPE"
XP_053963976.1	12	MetaCyc: PWY-7385;Reactome: R-HSA-70263;MetaCyc: PWY-1042;MetaCyc: PWY-1861;KEGG: 00710+4.1.2.13;MetaCyc: PWY-5484;KEGG: 00051+4.1.2.13;MetaCyc: PWY-6142;Reactome: R-HSA-70171;KEGG: 00680+4.1.2.13;KEGG: 00030+4.1.2.13;KEGG: 00010+4.1.2.13	"1,3-propanediol biosynthesis (engineered)";"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Carbon fixation in photosynthetic organisms";"Glycolysis II (from fructose 6-phosphate)";"Fructose and mannose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis";"Methane metabolism";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis"
XP_053968683.1	4	Reactome: R-HSA-1170546;Reactome: R-HSA-2586552;Reactome: R-HSA-983231;Reactome: R-HSA-982772	"Prolactin receptor signaling";"Signaling by Leptin";"Factors involved in megakaryocyte development and platelet production";"Growth hormone receptor signaling"
XP_053952825.1	3	Reactome: R-HSA-5693571;Reactome: R-HSA-164843;Reactome: R-HSA-3108214	"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation";"SUMOylation of DNA damage response and repair proteins"
XP_053962658.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.20	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053959740.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053966614.1	6	KEGG: 04070+3.1.3.64+3.1.3.95;Reactome: R-HSA-1660499;KEGG: 00562+3.1.3.64+3.1.3.95;MetaCyc: PWY-6368;MetaCyc: PWY-6580;MetaCyc: PWY-6367	"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Phosphatidylinositol biosynthesis I (bacteria)";"D-myo-inositol-5-phosphate metabolism"
XP_053965741.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_053965873.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053959078.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053965577.1	15	Reactome: R-HSA-2559585;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-9029569;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593	"Oncogene Induced Senescence";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity"
XP_053955414.1	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
XP_053970065.1	7	MetaCyc: PWY-7219;MetaCyc: PWY-6124;Reactome: R-HSA-73817;MetaCyc: PWY-7234;KEGG: 00250+4.3.2.2;KEGG: 00230+4.3.2.2;MetaCyc: PWY-6123	"Adenosine ribonucleotides de novo biosynthesis";"Inosine-5'-phosphate biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Purine metabolism";"Inosine-5'-phosphate biosynthesis I"
XP_053949872.1	17	Reactome: R-HSA-1169091;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-445989;Reactome: R-HSA-9645460;Reactome: R-HSA-937042;Reactome: R-HSA-450321;Reactome: R-HSA-5607764;Reactome: R-HSA-5689880;Reactome: R-HSA-975163;Reactome: R-HSA-450302;Reactome: R-HSA-9014325;Reactome: R-HSA-937072;Reactome: R-HSA-4086398;Reactome: R-HSA-9020702;Reactome: R-HSA-2871837;Reactome: R-HSA-202424	"Activation of NF-kappaB in B cells";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Alpha-protein kinase 1 signaling pathway";"IRAK2 mediated activation of TAK1 complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"CLEC7A (Dectin-1) signaling";"Ub-specific processing proteases";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"activated TAK1 mediates p38 MAPK activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Ca2+ pathway";"Interleukin-1 signaling";"FCERI mediated NF-kB activation";"Downstream TCR signaling"
XP_053966539.1	3	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
XP_053959134.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950376.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053968108.1	6	Reactome: R-HSA-2046105;Reactome: R-HSA-390247;Reactome: R-HSA-9603798;Reactome: R-HSA-5684045;Reactome: R-HSA-1369062;Reactome: R-HSA-2046106	"Linoleic acid (LA) metabolism";"Beta-oxidation of very long chain fatty acids";"Class I peroxisomal membrane protein import";"Defective ABCD1 causes adrenoleukodystrophy (ALD)";"ABC transporters in lipid homeostasis";"alpha-linolenic acid (ALA) metabolism"
XP_053950634.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053949037.1	3	MetaCyc: PWY-6596;Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6	"Adenosine nucleotides degradation I";"Purine salvage";"Purine metabolism"
XP_053946136.1	4	Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712	"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport"
XP_053949701.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_053952322.1	7	Reactome: R-HSA-168333;Reactome: R-HSA-1655829;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-203927;Reactome: R-HSA-6784531;Reactome: R-HSA-165054	"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"MicroRNA (miRNA) biogenesis";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA"
XP_053967272.1	7	KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053961538.1	14	KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-6803;Reactome: R-HSA-975634;Reactome: R-HSA-1482788;MetaCyc: PWY-7417;MetaCyc: PWY-8053	"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Retinoid metabolism and transport";"Acyl chain remodelling of PC";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II"
XP_053962901.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053963388.1	4	KEGG: 00330+2.5.1.16;KEGG: 00270+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00480+2.5.1.16	"Arginine and proline metabolism";"Cysteine and methionine metabolism";"Metabolism of polyamines";"Glutathione metabolism"
XP_053954379.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053960516.1	42	Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-110331;Reactome: R-HSA-1912408;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-5693607;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-427413;Reactome: R-HSA-3214842;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-2299718;Reactome: R-HSA-3214815;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-73728;Reactome: R-HSA-3214858;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5334118;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-9018519;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-212300;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-2559580;Reactome: R-HSA-912446	"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"Cleavage of the damaged purine";"Pre-NOTCH Transcription and Translation";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Processing of DNA double-strand break ends";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"NoRC negatively regulates rRNA expression";"HDMs demethylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"Condensation of Prophase Chromosomes";"HDACs deacetylate histones";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Opening";"RMTs methylate histone arginines";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"DNA methylation";"Packaging Of Telomere Ends";"Meiotic synapsis";"Estrogen-dependent gene expression";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"PRC2 methylates histones and DNA";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Oxidative Stress Induced Senescence";"Meiotic recombination"
XP_053953283.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053951906.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053963430.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053968355.1	4	KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193;Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48	"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I";"Pyrimidine salvage";"Drug metabolism - other enzymes"
XP_053956413.1	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
XP_053965074.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053948470.1	11	Reactome: R-HSA-210455;MetaCyc: PWY-5675;KEGG: 00630+6.3.1.2;MetaCyc: PWY-6964;MetaCyc: PWY-6549;MetaCyc: PWY-6963;KEGG: 00220+6.3.1.2;KEGG: 00910+6.3.1.2;Reactome: R-HSA-8964539;KEGG: 00250+6.3.1.2;MetaCyc: PWY-381	"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Nitrate reduction V (assimilatory)";"Glyoxylate and dicarboxylate metabolism";"Ammonia assimilation cycle II";"L-glutamine biosynthesis III";"Ammonia assimilation cycle I";"Arginine biosynthesis";"Nitrogen metabolism";"Glutamate and glutamine metabolism";"Alanine, aspartate and glutamate metabolism";"Nitrate reduction II (assimilatory)"
XP_053946275.1	5	Reactome: R-HSA-446210;MetaCyc: PWY-6749;MetaCyc: PWY-8013;KEGG: 00250+2.6.1.16;KEGG: 00520+2.6.1.16	"Synthesis of UDP-N-acetyl-glucosamine";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Amino sugar and nucleotide sugar metabolism"
XP_053955891.1	4	MetaCyc: PWY-7285;MetaCyc: PWY-6829;MetaCyc: PWY-7286;Reactome: R-HSA-6782861	"Methylwyosine biosynthesis";"Trna methylation (yeast)";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Synthesis of wybutosine at G37 of tRNA(Phe)"
XP_053969890.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053945906.1	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
XP_053950820.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053966561.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053947705.1	3	MetaCyc: PWY-5697;MetaCyc: PWY-5698;KEGG: 00230+3.5.2.5	"Allantoin degradation to ureidoglycolate I (urea producing)";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Purine metabolism"
XP_053965744.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053948478.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053966611.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_053961088.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053967283.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_053966346.1	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
XP_053959203.1	22	MetaCyc: PWY-7619;MetaCyc: PWY-7724;MetaCyc: PWY-6598;MetaCyc: PWY-7727;MetaCyc: PWY-7606;Reactome: R-HSA-75876;MetaCyc: PWY-7035;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7725;MetaCyc: PWY-7053;MetaCyc: PWY-8041;MetaCyc: PWY-5353;MetaCyc: PWY-7728;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-7726;MetaCyc: PWY-5080;MetaCyc: PWY-7049;MetaCyc: PWY-7036;MetaCyc: PWY-7592;MetaCyc: PWY-6958	"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Sciadonate biosynthesis";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Icosapentaenoate biosynthesis I (lower eukaryotes)"
XP_053967979.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053952090.1	7	Reactome: R-HSA-70635;MetaCyc: PWY-46;KEGG: 00330+3.5.3.1;MetaCyc: PWY-4984;MetaCyc: PWY-31;MetaCyc: PWY-6922;KEGG: 00220+3.5.3.1	"Urea cycle";"Putrescine biosynthesis III";"Arginine and proline metabolism";"Urea cycle";"Canavanine degradation";"L-Ndelta-acetylornithine biosynthesis";"Arginine biosynthesis"
XP_053949883.1	6	MetaCyc: PWY-5653;MetaCyc: PWY-5381;KEGG: 00760+6.3.5.1;MetaCyc: PWY-7761;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807	"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
XP_053966067.1	6	MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_053968100.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_053955407.1	1	Reactome: R-HSA-8964572	"Lipid particle organization"
XP_053964980.1	10	Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-9022699;Reactome: R-HSA-9022538;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-3899300;Reactome: R-HSA-9022692	"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"SUMOylation of transcription cofactors";"Regulation of MECP2 expression and activity"
XP_053954006.1	4	Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"MHC class II antigen presentation";"RHO GTPases activate KTN1";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053958676.1	6	Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase"
XP_053949531.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;Reactome: R-HSA-2206291	"Neutrophil degranulation";"HS-GAG degradation";"MPS IIIC - Sanfilippo syndrome C"
XP_053950782.1	8	Reactome: R-HSA-5673001;Reactome: R-HSA-438066;MetaCyc: PWY-7221;Reactome: R-HSA-9609736;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-9620244;KEGG: 00230+2.7.4.8	"RAF/MAP kinase cascade";"Unblocking of NMDA receptors, glutamate binding and activation";"Guanosine ribonucleotides de novo biosynthesis";"Assembly and cell surface presentation of NMDA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Long-term potentiation";"Purine metabolism"
XP_053963380.1	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
XP_053946323.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_053946975.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053956094.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053945206.1	2	Reactome: R-HSA-429958;Reactome: R-HSA-390471	"mRNA decay by 3' to 5' exoribonuclease";"Association of TriC/CCT with target proteins during biosynthesis"
XP_053949968.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053966012.1	5	Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712	"Amino acids regulate mTORC1";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport"
XP_053961239.1	4	Reactome: R-HSA-5250958;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361	"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Neurexins and neuroligins"
XP_053955334.1	3	Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067	"Glycogen synthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)"
XP_053949813.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_053964039.1	3	Reactome: R-HSA-3214858;Reactome: R-HSA-191859;Reactome: R-HSA-6804760	"RMTs methylate histone arginines";"snRNP Assembly";"Regulation of TP53 Activity through Methylation"
XP_053959101.1	9	MetaCyc: PWY-241;MetaCyc: PWY-5744;MetaCyc: PWY-7117;Reactome: R-HSA-1475029;MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5789	"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle"
XP_053961232.1	4	Reactome: R-HSA-5250958;Reactome: R-HSA-6794361;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Toxicity of botulinum toxin type B (BoNT/B)";"Neurexins and neuroligins";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053950601.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053947441.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_053954716.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053964877.1	1	Reactome: R-HSA-390696	"Adrenoceptors"
XP_053967213.1	10	KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;MetaCyc: PWY-5030;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-2201;MetaCyc: PWY-1722;MetaCyc: PWY-6613;MetaCyc: PWY-7909;Reactome: R-HSA-196757;MetaCyc: PWY-5497	"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"L-histidine degradation III";"One carbon pool by folate";"Folate transformations I";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"Metabolism of folate and pterines";"Purine nucleobases degradation II (anaerobic)"
XP_053949051.1	1	KEGG: 00270+2.1.1.37	"Cysteine and methionine metabolism"
XP_053958454.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053947015.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_053965541.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053954313.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_053965777.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053957318.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053950712.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053968229.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053963626.1	2	Reactome: R-HSA-389661;Reactome: R-HSA-9033241	"Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import"
XP_053961261.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053962827.1	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_053948324.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053966930.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_053964061.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053957310.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053954756.1	8	Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-8943724;Reactome: R-HSA-2559580;Reactome: R-HSA-3214841;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-8953750	"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of PTEN gene transcription";"Oxidative Stress Induced Senescence";"PKMTs methylate histone lysines";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"Transcriptional Regulation by E2F6"
XP_053956605.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053961932.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053953860.1	4	Reactome: R-HSA-418594;Reactome: R-HSA-112043;Reactome: R-HSA-202040;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"PLC beta mediated events";"G-protein activation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_053964863.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053960097.1	1	Reactome: R-HSA-8964038	"LDL clearance"
XP_053966938.1	5	MetaCyc: PWY-6558;Reactome: R-HSA-3656237;Reactome: R-HSA-3656253;KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"Defective EXT2 causes exostoses 2";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"HS-GAG biosynthesis"
XP_053964589.1	13	MetaCyc: PWY-5123;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-7182;MetaCyc: PWY-7709;MetaCyc: PWY-7721;MetaCyc: PWY-6383;MetaCyc: PWY-5122;MetaCyc: PWY-6859;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410	"Trans, trans-farnesyl diphosphate biosynthesis";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Linalool biosynthesis I";"(3R)-linalool biosynthesis";"Methyl phomopsenoate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"All-trans-farnesol biosynthesis";"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis"
XP_053948906.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053958891.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
XP_053952215.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions"
XP_053966764.1	6	Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-416476;Reactome: R-HSA-399997;Reactome: R-HSA-456926;Reactome: R-HSA-428930	"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"G alpha (q) signalling events";"Acetylcholine regulates insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor"
XP_053957626.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053947599.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053962234.1	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
XP_053951470.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053964582.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_053960403.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053960442.1	42	Reactome: R-HSA-427413;Reactome: R-HSA-2299718;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-110331;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-1912408;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-5693607;Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-2559580;Reactome: R-HSA-912446;Reactome: R-HSA-9018519;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-977225;Reactome: R-HSA-5693571;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5334118;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-3214858;Reactome: R-HSA-3214815;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886	"NoRC negatively regulates rRNA expression";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"Cleavage of the damaged purine";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Pre-NOTCH Transcription and Translation";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Processing of DNA double-strand break ends";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"Oxidative Stress Induced Senescence";"Meiotic recombination";"Estrogen-dependent gene expression";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Amyloid fiber formation";"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Packaging Of Telomere Ends";"Meiotic synapsis";"DNA methylation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RMTs methylate histone arginines";"HDACs deacetylate histones";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"
XP_053949504.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053958414.1	1	Reactome: R-HSA-1614635	"Sulfur amino acid metabolism"
XP_053967570.1	5	Reactome: R-HSA-9033500;MetaCyc: PWY-7782;Reactome: R-HSA-9033241;KEGG: 00565+2.5.1.26;Reactome: R-HSA-75896	"TYSND1 cleaves peroxisomal proteins";"Plasmalogen biosynthesis";"Peroxisomal protein import";"Ether lipid metabolism";"Plasmalogen biosynthesis"
XP_053965499.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053949689.1	5	MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6317	"D-galactose detoxification";"Galactose metabolism";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)"
XP_053962355.1	2	Reactome: R-HSA-8986944;Reactome: R-HSA-203927	"Transcriptional Regulation by MECP2";"MicroRNA (miRNA) biogenesis"
XP_053959739.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053957313.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053945332.1	4	KEGG: 00270+5.3.1.23;Reactome: R-HSA-72731;MetaCyc: PWY-7174;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"Recycling of eIF2:GDP";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053969016.1	16	Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459;Reactome: R-HSA-5628897;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398;Reactome: R-HSA-1912408;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-2559585;Reactome: R-HSA-8943723;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692	"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by MECP2";"Ca2+ pathway";"Pre-NOTCH Transcription and Translation";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Oncogene Induced Senescence";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity"
XP_053948395.1	6	MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_053964860.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053961851.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053970155.1	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
XP_053967061.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053962528.1	1	Reactome: R-HSA-8851805	"MET activates RAS signaling"
XP_053952484.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053967573.1	5	Reactome: R-HSA-75896;Reactome: R-HSA-9033500;KEGG: 00565+2.5.1.26;MetaCyc: PWY-7782;Reactome: R-HSA-9033241	"Plasmalogen biosynthesis";"TYSND1 cleaves peroxisomal proteins";"Ether lipid metabolism";"Plasmalogen biosynthesis";"Peroxisomal protein import"
XP_053962108.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053959476.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053962499.1	7	Reactome: R-HSA-156711;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-69202	"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin E associated events during G1/S transition"
XP_053952865.1	10	Reactome: R-HSA-70370;MetaCyc: PWY-7328;Reactome: R-HSA-5609977;MetaCyc: PWY-6397;MetaCyc: PWY-7344;MetaCyc: PWY-6527;KEGG: 00052+5.1.3.2;MetaCyc: PWY-3821;KEGG: 00520+5.1.3.2;MetaCyc: PWY-6317	"Galactose catabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"UDP-alpha-D-galactose biosynthesis";"Stachyose degradation";"Galactose metabolism";"D-galactose detoxification";"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)"
XP_053958322.1	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
XP_053947191.1	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_053951489.1	5	Reactome: R-HSA-3928665;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"EPH-ephrin mediated repulsion of cells";"Gap junction degradation";"Formation of annular gap junctions";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053954358.1	52	Reactome: R-HSA-9018519;Reactome: R-HSA-1834949;Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-167242;Reactome: R-HSA-76061;Reactome: R-HSA-73776;Reactome: R-HSA-6781823;Reactome: R-HSA-203927;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-6781827;Reactome: R-HSA-167162;Reactome: R-HSA-6782135;Reactome: R-HSA-5578749;Reactome: R-HSA-76071;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-167238;Reactome: R-HSA-5601884;Reactome: R-HSA-8851708;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-72165;Reactome: R-HSA-5617472;Reactome: R-HSA-76066;Reactome: R-HSA-5250924;Reactome: R-HSA-6803529;Reactome: R-HSA-168325;Reactome: R-HSA-6807505;Reactome: R-HSA-167246;Reactome: R-HSA-73863;Reactome: R-HSA-72086;Reactome: R-HSA-72163;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-77075;Reactome: R-HSA-167160;Reactome: R-HSA-72203;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-73772	"Estrogen-dependent gene expression";"Cytosolic sensors of pathogen-associated DNA";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase II Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"MicroRNA (miRNA) biogenesis";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II HIV Promoter Escape";"Dual incision in TC-NER";"Transcriptional regulation by small RNAs";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"Pausing and recovery of Tat-mediated HIV elongation";"PIWI-interacting RNA (piRNA) biogenesis";"Signaling by FGFR2 IIIa TM";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"mRNA Splicing - Minor Pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"B-WICH complex positively regulates rRNA expression";"FGFR2 alternative splicing";"Viral Messenger RNA Synthesis";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase I Transcription Termination";"mRNA Capping";"mRNA Splicing - Major Pathway";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Promoter Escape"
XP_053951467.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053962315.1	1	Reactome: R-HSA-1483255	"PI Metabolism"
XP_053953032.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053962100.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_053955266.1	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_053945467.1	8	Reactome: R-HSA-1483148;KEGG: 04658+3.1.3.16;MetaCyc: PWY-5668;KEGG: 04660+3.1.3.16;MetaCyc: PWY-5269;KEGG: 05235+3.1.3.16;KEGG: 00564+3.1.3.27;MetaCyc: PWY-7817	"Synthesis of PG";"Th1 and Th2 cell differentiation";"Cardiolipin biosynthesis I";"T cell receptor signaling pathway";"Cardiolipin biosynthesis II";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_053954525.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053946585.1	1	Reactome: R-HSA-1169408	"ISG15 antiviral mechanism"
XP_053955255.1	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_053969692.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-6798695	"Protein ubiquitination";"Neutrophil degranulation"
XP_053965934.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053956330.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053959847.1	4	Reactome: R-HSA-419037;Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-112308	"NCAM1 interactions";"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"Presynaptic depolarization and calcium channel opening"
XP_053963313.1	1	Reactome: R-HSA-71288	"Creatine metabolism"
XP_053957756.1	3	Reactome: R-HSA-418457;Reactome: R-HSA-4086398;Reactome: R-HSA-392517	"cGMP effects";"Ca2+ pathway";"Rap1 signalling"
XP_053954105.1	2	Reactome: R-HSA-9603798;Reactome: R-HSA-1369062	"Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis"
XP_053949858.1	2	Reactome: R-HSA-201681;Reactome: R-HSA-3772470	"TCF dependent signaling in response to WNT";"Negative regulation of TCF-dependent signaling by WNT ligand antagonists"
XP_053953617.1	1	Reactome: R-HSA-2565942	"Regulation of PLK1 Activity at G2/M Transition"
XP_053961494.1	4	Reactome: R-HSA-947581;MetaCyc: PWY-7250;Reactome: R-HSA-1362409;KEGG: 00730+2.8.1.7	"Molybdenum cofactor biosynthesis";"[2Fe-2S] iron-sulfur cluster biosynthesis";"Mitochondrial iron-sulfur cluster biogenesis";"Thiamine metabolism"
XP_053959509.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053966104.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053967863.1	4	Reactome: R-HSA-2122947;Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-201722	"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex"
XP_053966933.1	56	Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-202424;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-4608870;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-382556	"Degradation of AXIN";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"Downstream TCR signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Asymmetric localization of PCP proteins";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport"
XP_053957765.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053964868.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053959684.1	1	Reactome: R-HSA-75153	"Apoptotic execution phase"
XP_053964196.1	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
XP_053953250.1	8	Reactome: R-HSA-5099900;Reactome: R-HSA-196025;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-5140745;Reactome: R-HSA-190873;Reactome: R-HSA-432720	"WNT5A-dependent internalization of FZD4";"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Gap junction degradation";"Lysosome Vesicle Biogenesis"
XP_053962229.1	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
XP_053950778.1	12	Reactome: R-HSA-442982;Reactome: R-HSA-9617324;KEGG: 00230+2.7.4.8;Reactome: R-HSA-399719;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001;Reactome: R-HSA-9609736;Reactome: R-HSA-438066;MetaCyc: PWY-7221;Reactome: R-HSA-447038;Reactome: R-HSA-451308;Reactome: R-HSA-8849932	"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Purine metabolism";"Trafficking of AMPA receptors";"Long-term potentiation";"RAF/MAP kinase cascade";"Assembly and cell surface presentation of NMDA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"Guanosine ribonucleotides de novo biosynthesis";"NrCAM interactions";"Activation of Ca-permeable Kainate Receptor";"Synaptic adhesion-like molecules"
XP_053957433.1	4	KEGG: 00900+2.5.1.87;Reactome: R-HSA-446199;MetaCyc: PWY-6129;Reactome: R-HSA-4755609	"Terpenoid backbone biosynthesis";"Synthesis of Dolichyl-phosphate";"Dolichol and dolichyl phosphate biosynthesis";"Defective DHDDS causes retinitis pigmentosa 59"
XP_053970185.1	4	Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
XP_053952454.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053955985.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053961881.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053948645.1	2	Reactome: R-HSA-8854518;Reactome: R-HSA-6804756	"AURKA Activation by TPX2";"Regulation of TP53 Activity through Phosphorylation"
XP_053949880.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053952093.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053949944.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_053951412.1	5	Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-3214815;Reactome: R-HSA-2894862	"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053965201.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_053961924.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_053959614.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053961160.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053964983.1	10	Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-9022699;Reactome: R-HSA-9022538;Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-9022692;Reactome: R-HSA-3899300	"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of MECP2 expression and activity";"SUMOylation of transcription cofactors"
XP_053968103.1	6	Reactome: R-HSA-390247;Reactome: R-HSA-2046105;Reactome: R-HSA-5684045;Reactome: R-HSA-9603798;Reactome: R-HSA-1369062;Reactome: R-HSA-2046106	"Beta-oxidation of very long chain fatty acids";"Linoleic acid (LA) metabolism";"Defective ABCD1 causes adrenoleukodystrophy (ALD)";"Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis";"alpha-linolenic acid (ALA) metabolism"
XP_053959908.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
XP_053948489.1	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
XP_053958915.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_053953095.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053961896.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053950107.1	4	Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_053966070.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053969303.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053946555.1	2	Reactome: R-HSA-8964539;Reactome: R-HSA-2151201	"Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis"
XP_053955285.1	5	MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00020+1.2.4.2	"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)"
XP_053960976.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053946328.1	2	Reactome: R-HSA-8964539;Reactome: R-HSA-2151201	"Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis"
XP_053968760.1	19	Reactome: R-HSA-936837;Reactome: R-HSA-9649948;Reactome: R-HSA-6802946;Reactome: R-HSA-9609736;Reactome: R-HSA-6802955;Reactome: R-HSA-438066;Reactome: R-HSA-9620244;Reactome: R-HSA-399719;Reactome: R-HSA-9022692;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-442982;Reactome: R-HSA-111932;Reactome: R-HSA-5578775;Reactome: R-HSA-877300;Reactome: R-HSA-5673000;Reactome: R-HSA-6802952;Reactome: R-HSA-5673001;Reactome: R-HSA-5576892	"Ion transport by P-type ATPases";"Signaling downstream of RAS mutants";"Signaling by moderate kinase activity BRAF mutants";"Assembly and cell surface presentation of NMDA receptors";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Unblocking of NMDA receptors, glutamate binding and activation";"Long-term potentiation";"Trafficking of AMPA receptors";"Regulation of MECP2 expression and activity";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Ras activation upon Ca2+ influx through NMDA receptor";"CaMK IV-mediated phosphorylation of CREB";"Ion homeostasis";"Interferon gamma signaling";"RAF activation";"Signaling by BRAF and RAF fusions";"RAF/MAP kinase cascade";"Phase 0 - rapid depolarisation"
XP_053956025.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053967687.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053967662.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_053947293.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053951395.1	5	Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"HCMV Late Events"
XP_053967288.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053966131.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053946656.1	2	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_053950154.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_053957786.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053969893.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053964972.1	10	Reactome: R-HSA-9022699;Reactome: R-HSA-9022538;Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-3899300;Reactome: R-HSA-9022692;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-8936459;Reactome: R-HSA-400206	"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"SUMOylation of transcription cofactors";"Regulation of MECP2 expression and activity";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha"
XP_053950823.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053947165.1	9	MetaCyc: PWY-7411;MetaCyc: PWY-7902;MetaCyc: PWY-5981;Reactome: R-HSA-1483166;KEGG: 00564+1.1.1.8;KEGG: 00564+1.1.1.94;MetaCyc: PWY-7385;MetaCyc: PWY-5667;MetaCyc: PWY-6118	"Phosphatidate biosynthesis (yeast)";"Glucosylglycerol biosynthesis";"CDP-diacylglycerol biosynthesis III";"Synthesis of PA";"Glycerophospholipid metabolism";"Glycerophospholipid metabolism";"1,3-propanediol biosynthesis (engineered)";"CDP-diacylglycerol biosynthesis I";"Glycerol-3-phosphate shuttle"
XP_053950527.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053964979.1	10	Reactome: R-HSA-427413;Reactome: R-HSA-983231;Reactome: R-HSA-9022538;Reactome: R-HSA-9022699;Reactome: R-HSA-400206;Reactome: R-HSA-8936459;Reactome: R-HSA-9615017;Reactome: R-HSA-9022702;Reactome: R-HSA-9022692;Reactome: R-HSA-3899300	"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates neuronal receptors and channels";"Regulation of lipid metabolism by PPARalpha";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates transcription of neuronal ligands";"Regulation of MECP2 expression and activity";"SUMOylation of transcription cofactors"
XP_053969597.1	5	Reactome: R-HSA-674695;Reactome: R-HSA-201722;Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"Formation of the beta-catenin:TCF transactivating complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
XP_053958215.1	11	MetaCyc: PWY-8055;MetaCyc: PWY-8052;MetaCyc: PWY-8051;MetaCyc: PWY-8053;Reactome: R-HSA-2029485;KEGG: 00561+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;MetaCyc: PWY-6453;KEGG: 00564+3.1.3.4;KEGG: 00565+3.1.3.4	"Palmitoyl ethanolamide biosynthesis";"2-arachidonoylglycerol biosynthesis";"Anandamide biosynthesis I";"Anandamide biosynthesis II";"Role of phospholipids in phagocytosis";"Glycerolipid metabolism";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Ether lipid metabolism"
XP_053949888.1	6	MetaCyc: PWY-5653;MetaCyc: PWY-5381;KEGG: 00760+6.3.5.1;MetaCyc: PWY-7761;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807	"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
XP_053946099.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_053961306.1	20	Reactome: R-HSA-1632852;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-165159;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5674400;Reactome: R-HSA-1257604;Reactome: R-HSA-3371571;KEGG: 04714+2.7.11.1;Reactome: R-HSA-8943724;KEGG: 05170+2.7.11.1;Reactome: R-HSA-166208;KEGG: 05163+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-9639288;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-380972	"Macroautophagy";"PI3K-Akt signaling pathway";"TP53 Regulates Metabolic Genes";"mTOR signalling";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Constitutive Signaling by AKT1 E17K in Cancer";"PIP3 activates AKT signaling";"HSF1-dependent transactivation";"Thermogenesis";"Regulation of PTEN gene transcription";"Human immunodeficiency virus 1 infection";"mTORC1-mediated signalling";"Human cytomegalovirus infection";"CD28 dependent PI3K/Akt signaling";"Amino acids regulate mTORC1";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_053957666.1	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
XP_053956898.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_053957794.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053946785.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053954725.1	3	Reactome: R-HSA-264870;Reactome: R-HSA-6794361;Reactome: R-HSA-6798695	"Caspase-mediated cleavage of cytoskeletal proteins";"Neurexins and neuroligins";"Neutrophil degranulation"
XP_053945899.1	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
XP_053965326.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053961248.1	2	Reactome: R-HSA-110320;Reactome: R-HSA-983168	"Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053962138.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053961465.1	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
XP_053964770.1	3	Reactome: R-HSA-418597;Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13	"G alpha (z) signalling events";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_053948835.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053951892.1	4	Reactome: R-HSA-6807505;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"RNA polymerase II transcribes snRNA genes";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053961647.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053949941.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053951309.1	4	Reactome: R-HSA-499943;MetaCyc: PWY-7221;Reactome: R-HSA-2161541;KEGG: 00230+2.7.4.8	"Interconversion of nucleotide di- and triphosphates";"Guanosine ribonucleotides de novo biosynthesis";"Abacavir metabolism";"Purine metabolism"
XP_053947468.1	6	MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism"
XP_053955825.1	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
XP_053967767.1	4	Reactome: R-HSA-186763;Reactome: R-HSA-912631;Reactome: R-HSA-8875555;Reactome: R-HSA-8875656	"Downstream signal transduction";"Regulation of signaling by CBL";"MET activates RAP1 and RAC1";"MET receptor recycling"
XP_053967782.1	12	MetaCyc: PWY-6672;MetaCyc: PWY-5108;MetaCyc: PWY-7118;KEGG: 00720+6.2.1.1;KEGG: 00620+6.2.1.1;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5132;MetaCyc: PWY-5133;KEGG: 00630+6.2.1.1;MetaCyc: PWY-7857;KEGG: 00010+6.2.1.1;KEGG: 00640+6.2.1.1	"Cis-genanyl-coa degradation";"L-isoleucine biosynthesis V";"Chitin degradation to ethanol";"Carbon fixation pathways in prokaryotes";"Pyruvate metabolism";"Methane metabolism";"Lupulone and humulone biosynthesis";"Colupulone and cohumulone biosynthesis";"Glyoxylate and dicarboxylate metabolism";"Adlupulone and adhumulone biosynthesis";"Glycolysis / Gluconeogenesis";"Propanoate metabolism"
XP_053947245.1	5	MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085;MetaCyc: PWY-6902	"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate";"Chitin degradation II (Vibrio)"
XP_053949627.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053962741.1	10	Reactome: R-HSA-3214847;Reactome: R-HSA-201722;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5689880;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Ub-specific processing proteases";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053952775.1	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
XP_053959702.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053965658.1	4	Reactome: R-HSA-1655829;Reactome: R-HSA-8874211;Reactome: R-HSA-8963889;Reactome: R-HSA-381033	"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"CREB3 factors activate genes";"Assembly of active LPL and LIPC lipase complexes";"ATF6 (ATF6-alpha) activates chaperones"
XP_053949920.1	42	KEGG: 00903+4.2.1.17;MetaCyc: PWY-6945;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-6883;KEGG: 00592+4.2.1.17;MetaCyc: PWY-6863;MetaCyc: PWY-7606;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;KEGG: 00410+4.2.1.17;MetaCyc: PWY-7007;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-7654;MetaCyc: PWY-7094;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;KEGG: 00627+4.2.1.17;MetaCyc: PWY-5109;MetaCyc: PWY-7778;KEGG: 00623+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;MetaCyc: PWY-5136;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;MetaCyc: PWY-6944;MetaCyc: PWY-7726;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-5138;MetaCyc: PWY-7216;MetaCyc: PWY-5789;MetaCyc: PWY-7401;MetaCyc: PWY-6435;MetaCyc: PWY-6583;MetaCyc: PWY-5177;KEGG: 00930+4.2.1.17+1.1.1.35;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361	"Limonene and pinene degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Butanoate metabolism";"Pyruvate fermentation to butanol II (engineered)";"alpha-Linolenic acid metabolism";"Pyruvate fermentation to hexanol (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Lysine degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"beta-Alanine metabolism";"Methyl ketone biosynthesis (engineered)";"Butanoate metabolism";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Fatty acid salvage";"Benzoate degradation";"Propanoate metabolism";"Geraniol degradation";"Spodoptera littoralis pheromone biosynthesis";"Aminobenzoate degradation";"Fermentation to 2-methylbutanoate";"2-methylpropene degradation";"Toluene degradation";"Fatty acid degradation";"Phenylalanine metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Carbon fixation pathways in prokaryotes";"Methyl tert-butyl ether degradation";"Androstenedione degradation";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid degradation";"Tryptophan metabolism";"Fatty acid beta-oxidation IV (unsaturated, even number)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"4-hydroxybenzoate biosynthesis III (plants)";"Pyruvate fermentation to butanol I";"Glutaryl-coa degradation";"Caprolactam degradation";"Fatty acid elongation";"Valine, leucine and isoleucine degradation";"Benzoyl-coa degradation I (aerobic)"
XP_053969845.1	5	Reactome: R-HSA-73863;Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-427413	"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression"
XP_053945302.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053965870.1	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
XP_053959709.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053959871.1	4	Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_053960380.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053963565.1	52	Reactome: R-HSA-73776;Reactome: R-HSA-76061;Reactome: R-HSA-203927;Reactome: R-HSA-167290;Reactome: R-HSA-6781823;Reactome: R-HSA-113418;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-6781827;Reactome: R-HSA-167162;Reactome: R-HSA-6782135;Reactome: R-HSA-76071;Reactome: R-HSA-5578749;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-167238;Reactome: R-HSA-5601884;Reactome: R-HSA-9018519;Reactome: R-HSA-1834949;Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-167242;Reactome: R-HSA-72086;Reactome: R-HSA-73863;Reactome: R-HSA-72163;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-77075;Reactome: R-HSA-167160;Reactome: R-HSA-72203;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-73772;Reactome: R-HSA-8851708;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-72165;Reactome: R-HSA-5617472;Reactome: R-HSA-76066;Reactome: R-HSA-5250924;Reactome: R-HSA-6803529;Reactome: R-HSA-168325;Reactome: R-HSA-6807505;Reactome: R-HSA-167246	"RNA Polymerase II Promoter Escape";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"MicroRNA (miRNA) biogenesis";"Pausing and recovery of HIV elongation";"Formation of TC-NER Pre-Incision Complex";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II HIV Promoter Escape";"Dual incision in TC-NER";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Transcriptional regulation by small RNAs";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Pausing and recovery of Tat-mediated HIV elongation";"PIWI-interacting RNA (piRNA) biogenesis";"Estrogen-dependent gene expression";"Cytosolic sensors of pathogen-associated DNA";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Capping";"RNA Polymerase I Transcription Termination";"mRNA Splicing - Major Pathway";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Promoter Escape";"Signaling by FGFR2 IIIa TM";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"mRNA Splicing - Minor Pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"B-WICH complex positively regulates rRNA expression";"FGFR2 alternative splicing";"Viral Messenger RNA Synthesis";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript"
XP_053961416.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_053952894.1	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_053952226.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053959532.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_053962653.1	20	Reactome: R-HSA-75105;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00720+2.3.3.8;MetaCyc: PWY-6969;MetaCyc: PWY-5172;MetaCyc: PWY-5537;MetaCyc: PWY-5690;Reactome: R-HSA-1268020;MetaCyc: PWY-7384;MetaCyc: PWY-6728;Reactome: R-HSA-71403;Reactome: R-HSA-6798695;MetaCyc: PWY-5913;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;Reactome: R-HSA-163765;KEGG: 00020+2.3.3.8;KEGG: 00660+6.2.1.5	"Fatty acyl-CoA biosynthesis";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Acetyl-coa biosynthesis III (from citrate)";"Pyruvate fermentation to acetate V";"TCA cycle II (plants and fungi)";"Mitochondrial protein import";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Neutrophil degranulation";"Partial TCA cycle (obligate autotrophs)";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"ChREBP activates metabolic gene expression";"Citrate cycle (TCA cycle)";"C5-Branched dibasic acid metabolism"
XP_053950151.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053965650.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053964114.1	3	Reactome: R-HSA-8856828;Reactome: R-HSA-8854214;Reactome: R-HSA-8875656	"Clathrin-mediated endocytosis";"TBC/RABGAPs";"MET receptor recycling"
XP_053959651.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053952357.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053962071.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_053963666.1	18	Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-167242;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-113418;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-72086;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-77075;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-75955	"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of the Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation"
XP_053961221.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053960438.1	7	Reactome: R-HSA-2660826;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-177929;Reactome: R-HSA-1442490;Reactome: R-HSA-2644606;Reactome: R-HSA-2691232	"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Signaling by EGFR";"Collagen degradation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
XP_053967841.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053964778.1	3	KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508;Reactome: R-HSA-418597	"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"G alpha (z) signalling events"
XP_053958146.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053957516.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053961240.1	4	Reactome: R-HSA-5250958;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361	"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Neurexins and neuroligins"
XP_053961542.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053950196.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053949529.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;Reactome: R-HSA-2206291	"Neutrophil degranulation";"HS-GAG degradation";"MPS IIIC - Sanfilippo syndrome C"
XP_053961549.1	6	Reactome: R-HSA-201722;Reactome: R-HSA-381426;Reactome: R-HSA-5626467;Reactome: R-HSA-2173796;Reactome: R-HSA-3769402;Reactome: R-HSA-8957275	"Formation of the beta-catenin:TCF transactivating complex";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"RHO GTPases activate IQGAPs";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Deactivation of the beta-catenin transactivating complex";"Post-translational protein phosphorylation"
XP_053957097.1	17	KEGG: 00230+2.4.2.1;MetaCyc: PWY-6644;MetaCyc: PWY-6620;MetaCyc: PWY-6611;MetaCyc: PWY-6627;Reactome: R-HSA-6798695;Reactome: R-HSA-74217;KEGG: 00760+2.4.2.1;MetaCyc: PWY-7179;MetaCyc: PWY-4202;MetaCyc: PWY-6608;KEGG: 00240+2.4.2.1;MetaCyc: PWY-7179-1;MetaCyc: PWY-5695;Reactome: R-HSA-74259;MetaCyc: PWY-6609;MetaCyc: PWY-5532	"Purine metabolism";"Fluoroacetate and fluorothreonine biosynthesis";"Guanine and guanosine salvage";"Adenine and adenosine salvage V";"Salinosporamide A biosynthesis";"Neutrophil degranulation";"Purine salvage";"Nicotinate and nicotinamide metabolism";"Purine deoxyribonucleosides degradation I";"Arsenate detoxification I (mammalian)";"Guanosine nucleotides degradation III";"Pyrimidine metabolism";"Purine deoxyribonucleosides degradation II";"Inosine 5'-phosphate degradation";"Purine catabolism";"Adenine and adenosine salvage III";"Nucleoside and nucleotide degradation (archaea)"
XP_053949522.1	11	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-2559580;Reactome: R-HSA-450302;Reactome: R-HSA-4420097	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"p38MAPK events";"Oxidative Stress Induced Senescence";"activated TAK1 mediates p38 MAPK activation";"VEGFA-VEGFR2 Pathway"
XP_053950913.1	27	Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-168271;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-4570464	"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"ISG15 antiviral mechanism";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Transport of Ribonucleoproteins into the Host Nucleus";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"SUMOylation of RNA binding proteins"
XP_053953719.1	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
XP_053959059.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
XP_053948076.1	14	KEGG: 00720+1.3.5.1;MetaCyc: PWY-5690;MetaCyc: PWY-3781;Reactome: R-HSA-611105;MetaCyc: PWY-6969;MetaCyc: PWY-4302;KEGG: 00650+1.3.5.1;MetaCyc: PWY-561;KEGG: 00020+1.3.5.1;MetaCyc: PWY-7254;KEGG: 00190+1.3.5.1;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-7279	"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Aerobic respiration I (cytochrome c)";"Respiratory electron transport";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Aerobic respiration III (alternative oxidase pathway)";"Butanoate metabolism";"Superpathway of glyoxylate cycle and fatty acid degradation";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Oxidative phosphorylation";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Aerobic respiration II (cytochrome c) (yeast)"
XP_053961486.1	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
XP_053959595.1	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
XP_053960525.1	42	Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-9018519;Reactome: R-HSA-912446;Reactome: R-HSA-212300;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-2559580;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-3214815;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-5334118;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-3214842;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-2299718;Reactome: R-HSA-427413;Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-5693607;Reactome: R-HSA-110331;Reactome: R-HSA-1912408;Reactome: R-HSA-73772;Reactome: R-HSA-3214847	"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Estrogen-dependent gene expression";"Meiotic recombination";"PRC2 methylates histones and DNA";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Oxidative Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"HDACs deacetylate histones";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"DNA methylation";"Packaging Of Telomere Ends";"Meiotic synapsis";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"HDMs demethylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"Condensation of Prophase Chromosomes";"NoRC negatively regulates rRNA expression";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Processing of DNA double-strand break ends";"Cleavage of the damaged purine";"Pre-NOTCH Transcription and Translation";"RNA Polymerase I Promoter Escape";"HATs acetylate histones"
XP_053964622.1	7	MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-5469;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-7445;MetaCyc: PWY-6824	"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Sesamin biosynthesis";"Betanidin degradation";"Phenylpropanoid biosynthesis";"Luteolin triglucuronide degradation";"Justicidin B biosynthesis"
XP_053949498.1	8	KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00520+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00524+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1	"Galactose metabolism";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Glycolysis";"Neomycin, kanamycin and gentamicin biosynthesis";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis"
XP_053945693.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053964629.1	14	MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7601;MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7619;MetaCyc: PWY-7724;Reactome: R-HSA-75876	"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs"
XP_053961123.1	26	Reactome: R-HSA-174437;Reactome: R-HSA-6782210;Reactome: R-HSA-1362277;Reactome: R-HSA-5685942;Reactome: R-HSA-5358606;Reactome: R-HSA-174417;Reactome: R-HSA-110320;Reactome: R-HSA-5655862;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-6804114;Reactome: R-HSA-110312;Reactome: R-HSA-8866654;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-5358565;Reactome: R-HSA-5651801;Reactome: R-HSA-69166;Reactome: R-HSA-174414;Reactome: R-HSA-69091;Reactome: R-HSA-6782135;Reactome: R-HSA-69205;Reactome: R-HSA-4615885;Reactome: R-HSA-5656121;Reactome: R-HSA-110314;Reactome: R-HSA-5696400	"Removal of the Flap Intermediate from the C-strand";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription of E2F targets under negative control by DREAM complex";"HDR through Homologous Recombination (HRR)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Telomere C-strand (Lagging Strand) Synthesis";"Translesion Synthesis by POLH";"Translesion synthesis by POLK";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Translesion synthesis by REV1";"E3 ubiquitin ligases ubiquitinate target proteins";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"Processive synthesis on the C-strand of the telomere";"Polymerase switching";"Dual incision in TC-NER";"G1/S-Specific Transcription";"SUMOylation of DNA replication proteins";"Translesion synthesis by POLI";"Recognition of DNA damage by PCNA-containing replication complex";"Dual Incision in GG-NER"
XP_053957442.1	1	Reactome: R-HSA-70350	"Fructose catabolism"
XP_053957403.1	13	Reactome: R-HSA-5099900;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-8964038;Reactome: R-HSA-8866427;Reactome: R-HSA-5140745;Reactome: R-HSA-2132295;Reactome: R-HSA-182218;Reactome: R-HSA-177504;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-167590;Reactome: R-HSA-437239	"WNT5A-dependent internalization of FZD4";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"LDL clearance";"VLDLR internalisation and degradation";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation";"Retrograde neurotrophin signalling";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Nef Mediated CD4 Down-regulation";"Recycling pathway of L1"
XP_053957449.1	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
XP_053953064.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053952369.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053952387.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053952362.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053959681.1	3	Reactome: R-HSA-913709;Reactome: R-HSA-480985;KEGG: 00510+2.4.1.117	"O-linked glycosylation of mucins";"Synthesis of dolichyl-phosphate-glucose";"N-Glycan biosynthesis"
XP_053963403.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053946715.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053948343.1	1	MetaCyc: PWY-6938	"NADH repair"
XP_053959019.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053961491.1	4	Reactome: R-HSA-1362409;KEGG: 00730+2.8.1.7;MetaCyc: PWY-7250;Reactome: R-HSA-947581	"Mitochondrial iron-sulfur cluster biogenesis";"Thiamine metabolism";"[2Fe-2S] iron-sulfur cluster biosynthesis";"Molybdenum cofactor biosynthesis"
XP_053950860.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_053951835.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053950137.1	4	Reactome: R-HSA-70688;KEGG: 00330+1.5.5.2;MetaCyc: PWY-5737;MetaCyc: PWY-6922	"Proline catabolism";"Arginine and proline metabolism";"(5R)-carbapenem carboxylate biosynthesis";"L-Ndelta-acetylornithine biosynthesis"
XP_053960318.1	4	Reactome: R-HSA-917937;KEGG: 00860+1.14.14.18;MetaCyc: PWY-5874;Reactome: R-HSA-189483	"Iron uptake and transport";"Porphyrin and chlorophyll metabolism";"Heme degradation I";"Heme degradation"
XP_053946377.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_053962859.1	7	KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053966540.1	3	Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-674695	"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events"
XP_053967719.1	30	Reactome: R-HSA-211163;Reactome: R-HSA-1257604;Reactome: R-HSA-1358803;Reactome: R-HSA-8941332;Reactome: R-HSA-198693;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69656;Reactome: R-HSA-5674400;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-9634638;Reactome: R-HSA-389357;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9614399;Reactome: R-HSA-69202;Reactome: R-HSA-111447;Reactome: R-HSA-199418;Reactome: R-HSA-389513;Reactome: R-HSA-8876198;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6804757;Reactome: R-HSA-6804758;Reactome: R-HSA-5218920;Reactome: R-HSA-8948751;Reactome: R-HSA-198323;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-392451;Reactome: R-HSA-6804759	"AKT-mediated inactivation of FOXO1A";"PIP3 activates AKT signaling";"Downregulation of ERBB2:ERBB3 signaling";"RUNX2 regulates genes involved in cell migration";"AKT phosphorylates targets in the nucleus";"Relaxin signaling pathway";"Cyclin A:Cdk2-associated events at S phase entry";"Constitutive Signaling by AKT1 E17K in Cancer";"mTOR signaling pathway";"Human papillomavirus infection";"TP53 Regulates Metabolic Genes";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"CD28 dependent PI3K/Akt signaling";"Human cytomegalovirus infection";"Regulation of localization of FOXO transcription factors";"Cyclin E associated events during G1/S transition";"Activation of BAD and translocation to mitochondria";"Negative regulation of the PI3K/AKT network";"CTLA4 inhibitory signaling";"RAB GEFs exchange GTP for GDP on RABs";"PI3K-Akt signaling pathway";"Regulation of TP53 Degradation";"Regulation of TP53 Activity through Acetylation";"VEGFR2 mediated vascular permeability";"Regulation of PTEN stability and activity";"AKT phosphorylates targets in the cytosol";"Thermogenesis";"Human immunodeficiency virus 1 infection";"G beta:gamma signalling through PI3Kgamma";"Regulation of TP53 Activity through Association with Co-factors"
XP_053957036.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053968610.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_053948612.1	16	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72695	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex"
XP_053946503.1	7	Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-380320	"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes"
XP_053946549.1	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
XP_053945557.1	4	MetaCyc: PWY-7426;MetaCyc: PWY-7920;KEGG: 00513+3.2.1.114;KEGG: 00510+3.2.1.114	"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
XP_053967311.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053952739.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053953417.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053946807.1	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
XP_053955027.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053957063.1	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
XP_053961755.1	6	MetaCyc: PWY-7433;KEGG: 00512+2.4.1.122;KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632;MetaCyc: PWY-7290;Reactome: R-HSA-913709	"Mucin core 1 and core 2 O-glycosylation";"Mucin type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Escherichia coli serotype O86 O-antigen biosynthesis";"O-linked glycosylation of mucins"
XP_053963861.1	14	KEGG: 00565+3.1.3.4;Reactome: R-HSA-1483191;MetaCyc: PWY-6453;Reactome: R-HSA-75109;KEGG: 00564+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;KEGG: 00561+3.1.3.4;Reactome: R-HSA-1483213;MetaCyc: PWY-8055;Reactome: R-HSA-4419969;MetaCyc: PWY-8052;MetaCyc: PWY-8053;MetaCyc: PWY-8051	"Ether lipid metabolism";"Synthesis of PC";"Stigma estolide biosynthesis";"Triglyceride biosynthesis";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Glycerolipid metabolism";"Synthesis of PE";"Palmitoyl ethanolamide biosynthesis";"Depolymerisation of the Nuclear Lamina";"2-arachidonoylglycerol biosynthesis";"Anandamide biosynthesis II";"Anandamide biosynthesis I"
XP_053951557.1	14	KEGG: 00561+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-5981;MetaCyc: PWY-7589;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8053;MetaCyc: PWY-5667;MetaCyc: PWY-7417	"Glycerolipid metabolism";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Plasmalogen biosynthesis";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)"
XP_053969528.1	12	Reactome: R-HSA-71240;MetaCyc: PWY-801;MetaCyc: PWY-601;KEGG: 00380+2.6.1.7;MetaCyc: PWY-7901;KEGG: 00450+4.4.1.13;MetaCyc: PWY-6936;MetaCyc: PWY-2821;MetaCyc: PWY-6842;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6309;MetaCyc: PWY-1187	"Tryptophan catabolism";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from tryptophan";"Tryptophan metabolism";"Glucosinolate biosynthesis from tyrosine";"Selenocompound metabolism";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from phenylalanine";"Glutathione-mediated detoxification II";"Cysteine and methionine metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glucosinolate biosynthesis from homomethionine"
XP_053953351.1	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
XP_053946854.1	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
XP_053961363.1	19	Reactome: R-HSA-8963888;Reactome: R-HSA-8963901;Reactome: R-HSA-8964038;Reactome: R-HSA-5686938;Reactome: R-HSA-8964046;Reactome: R-HSA-3000480;Reactome: R-HSA-8866423;Reactome: R-HSA-8856828;Reactome: R-HSA-8964026;Reactome: R-HSA-8856825;Reactome: R-HSA-432142;Reactome: R-HSA-3000497;Reactome: R-HSA-8957275;Reactome: R-HSA-381426;Reactome: R-HSA-8964041;Reactome: R-HSA-3000471;Reactome: R-HSA-202733;Reactome: R-HSA-3000484;Reactome: R-HSA-975634	"Chylomicron assembly";"Chylomicron remodeling";"LDL clearance";"Regulation of TLR by endogenous ligand";"VLDL clearance";"Scavenging by Class A Receptors";"VLDL assembly";"Clathrin-mediated endocytosis";"Chylomicron clearance";"Cargo recognition for clathrin-mediated endocytosis";"Platelet sensitization by LDL";"Scavenging by Class H Receptors";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"LDL remodeling";"Scavenging by Class B Receptors";"Cell surface interactions at the vascular wall";"Scavenging by Class F Receptors";"Retinoid metabolism and transport"
XP_053967457.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053951682.1	9	MetaCyc: PWY-6367;Reactome: R-HSA-416476;Reactome: R-HSA-112043;MetaCyc: PWY-6351;MetaCyc: PWY-8052;MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11;Reactome: R-HSA-1855204	"D-myo-inositol-5-phosphate metabolism";"G alpha (q) signalling events";"PLC beta mediated events";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"2-arachidonoylglycerol biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol"
XP_053945667.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053947623.1	3	Reactome: R-HSA-8964208;KEGG: 00250+3.5.1.1;KEGG: 00460+3.5.1.1	"Phenylalanine metabolism";"Alanine, aspartate and glutamate metabolism";"Cyanoamino acid metabolism"
XP_053951011.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053950429.1	13	KEGG: 00603+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;KEGG: 00511+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916;Reactome: R-HSA-2022857;MetaCyc: PWY-7822	"Glycosphingolipid biosynthesis - globo and isoglobo series";"CS/DS degradation";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Other glycan degradation";"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation";"Keratan sulfate degradation";"Chitin degradation III (Serratia)"
XP_053954951.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_053960254.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_053948659.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_053959676.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053968308.1	12	MetaCyc: PWY-6142;KEGG: 00051+4.1.2.13;MetaCyc: PWY-5484;KEGG: 00710+4.1.2.13;MetaCyc: PWY-1861;MetaCyc: PWY-1042;MetaCyc: PWY-7385;Reactome: R-HSA-70263;KEGG: 00010+4.1.2.13;KEGG: 00030+4.1.2.13;KEGG: 00680+4.1.2.13;Reactome: R-HSA-70171	"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Pentose phosphate pathway";"Methane metabolism";"Glycolysis"
XP_053946674.1	3	Reactome: R-HSA-72165;Reactome: R-HSA-191859;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"snRNP Assembly";"mRNA Splicing - Major Pathway"
XP_053953545.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053962056.1	3	Reactome: R-HSA-525793;Reactome: R-HSA-5663220;Reactome: R-HSA-9634638	"Myogenesis";"RHO GTPases Activate Formins";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling"
XP_053945968.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_053969315.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-3270619;Reactome: R-HSA-1834949;Reactome: R-HSA-5693571;Reactome: R-HSA-164843	"Neutrophil degranulation";"IRF3-mediated induction of type I IFN";"Cytosolic sensors of pathogen-associated DNA";"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation"
XP_053947174.1	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
XP_053969100.1	7	KEGG: 00600+2.4.1.80;MetaCyc: PWY-7838;Reactome: R-HSA-1660662;MetaCyc: PWY-7839;MetaCyc: PWY-5129;MetaCyc: PWY-7836;MetaCyc: PWY-7841	"Sphingolipid metabolism";"Globo-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism";"Lacto-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)";"Ganglio-series glycosphingolipids biosynthesis";"Neolacto-series glycosphingolipids biosynthesis"
XP_053962065.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053963188.1	6	KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;MetaCyc: PWY-7900;Reactome: R-HSA-189085;KEGG: 00500+2.4.1.18;MetaCyc: PWY-622	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Starch biosynthesis"
XP_053957180.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053962699.1	4	KEGG: 00430+1.13.11.20;KEGG: 00270+1.13.11.20;Reactome: R-HSA-1614558;MetaCyc: PWY-5331	"Taurine and hypotaurine metabolism";"Cysteine and methionine metabolism";"Degradation of cysteine and homocysteine";"Taurine biosynthesis I"
XP_053960907.1	5	Reactome: R-HSA-4755579;Reactome: R-HSA-446199;KEGG: 00510+1.3.1.94;MetaCyc: PWY-6129;Reactome: R-HSA-193048	"Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ";"Synthesis of Dolichyl-phosphate";"N-Glycan biosynthesis";"Dolichol and dolichyl phosphate biosynthesis";"Androgen biosynthesis"
XP_053951813.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053969541.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053947718.1	16	KEGG: 00640+6.2.1.4;KEGG: 00660+6.2.1.5;KEGG: 00020+6.2.1.4;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-7384;MetaCyc: PWY-5690;MetaCyc: PWY-5537;MetaCyc: PWY-5392;MetaCyc: PWY-6969;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5749	"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"Citrate cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle II (plants and fungi)";"Pyruvate fermentation to acetate V";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"Itaconate degradation"
XP_053959816.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053945260.1	16	Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956	"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_053952509.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053969520.1	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
XP_053950235.1	26	Reactome: R-HSA-3899300;Reactome: R-HSA-400253;Reactome: R-HSA-3134973;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-1234158;Reactome: R-HSA-9013508;Reactome: R-HSA-1368082;Reactome: R-HSA-5621575;Reactome: R-HSA-1989781;Reactome: R-HSA-933541;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-918233;Reactome: R-HSA-8866907;Reactome: R-HSA-9614657;Reactome: R-HSA-9018519;Reactome: R-HSA-381340;Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-2894862;Reactome: R-HSA-9013695;Reactome: R-HSA-3371568;Reactome: R-HSA-9617629;Reactome: R-HSA-2122947	"SUMOylation of transcription cofactors";"Circadian Clock";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Regulation of gene expression by Hypoxia-inducible Factor";"NOTCH3 Intracellular Domain Regulates Transcription";"RORA activates gene expression";"CD209 (DC-SIGN) signaling";"PPARA activates gene expression";"TRAF6 mediated IRF7 activation";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF3-dependent IRF activation pathway";"Activation of the TFAP2 (AP-2) family of transcription factors";"FOXO-mediated transcription of cell death genes";"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription";"Attenuation phase";"Regulation of FOXO transcriptional activity by acetylation";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053958249.1	1	KEGG: 00970+6.1.1.22	"Aminoacyl-tRNA biosynthesis"
XP_053951051.1	3	MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167	"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol"
XP_053948587.1	20	Reactome: R-HSA-69091;Reactome: R-HSA-6782135;Reactome: R-HSA-5693616;Reactome: R-HSA-69473;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-5685942;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-5696400;Reactome: R-HSA-5685938;Reactome: R-HSA-110314;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5655862;Reactome: R-HSA-176187;Reactome: R-HSA-110320;Reactome: R-HSA-5656121	"Polymerase switching";"Dual incision in TC-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"G2/M DNA damage checkpoint";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual Incision in GG-NER";"HDR through Single Strand Annealing (SSA)";"Recognition of DNA damage by PCNA-containing replication complex";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Translesion synthesis by POLK";"Activation of ATR in response to replication stress";"Translesion Synthesis by POLH";"Translesion synthesis by POLI"
XP_053948260.1	9	Reactome: R-HSA-6804756;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-73776	"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape"
XP_053951883.1	16	Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053963633.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053947008.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_053969744.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053950292.1	10	KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-6842;MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-4061;MetaCyc: PWY-7112;MetaCyc: PWY-7559;MetaCyc: PWY-5826	"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Glutathione-mediated detoxification II";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Glutathione metabolism";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Glutathione degradation (DUG pathway";"Hypoglycin biosynthesis"
XP_053970234.1	9	Reactome: R-HSA-446193;KEGG: 00550+2.4.1.227;KEGG: 00510+2.4.1.141;Reactome: R-HSA-5633231;MetaCyc: PWY-6470;MetaCyc: PWY-5265;MetaCyc: PWY-6385;MetaCyc: PWY-6471;KEGG: 00513+2.4.1.141	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis";"N-Glycan biosynthesis";"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis II (staphylococci)";"Peptidoglycan biosynthesis III (mycobacteria)";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Various types of N-glycan biosynthesis"
XP_053948051.1	10	MetaCyc: PWY-5844;MetaCyc: PWY-5890;MetaCyc: PWY-5891;MetaCyc: PWY-5892;MetaCyc: PWY-5895;MetaCyc: PWY-7996;MetaCyc: PWY-5839;KEGG: 00130+2.1.1.163;Reactome: R-HSA-2142789;MetaCyc: PWY-5849	"Menaquinol-9 biosynthesis";"Menaquinol-10 biosynthesis";"Menaquinol-11 biosynthesis";"Menaquinol-12 biosynthesis";"Menaquinol-13 biosynthesis";"Menaquinol-4 biosynthesis I";"Menaquinol-7 biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol biosynthesis";"Menaquinol-6 biosynthesis"
XP_053963118.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053951587.1	2	KEGG: 00340+2.1.1.22;Reactome: R-HSA-70921	"Histidine metabolism";"Histidine catabolism"
XP_053951562.1	14	KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-7587;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-6453;MetaCyc: PWY-7589;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.51	"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Synthesis of PA";"Plasmalogen biosynthesis";"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism"
XP_053957305.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053962536.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053961344.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053945587.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_053965898.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053967396.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_053969385.1	1	Reactome: R-HSA-71288	"Creatine metabolism"
XP_053965166.1	11	Reactome: R-HSA-3656253;Reactome: R-HSA-1971475;Reactome: R-HSA-4420332;Reactome: R-HSA-202733;Reactome: R-HSA-975634;Reactome: R-HSA-3560801;Reactome: R-HSA-3000170;Reactome: R-HSA-2022928;Reactome: R-HSA-3560783;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096	"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Cell surface interactions at the vascular wall";"Retinoid metabolism and transport";"Defective B3GAT3 causes JDSSDHD";"Syndecan interactions";"HS-GAG biosynthesis";"Defective B4GALT7 causes EDS, progeroid type";"Defective EXT2 causes exostoses 2";"HS-GAG degradation"
XP_053952200.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling"
XP_053946921.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053963774.1	2	KEGG: 00970+6.1.1.1;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
XP_053945652.1	2	Reactome: R-HSA-1663150;Reactome: R-HSA-1660662	"The activation of arylsulfatases";"Glycosphingolipid metabolism"
XP_053948734.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_053948968.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053965308.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053945659.1	4	KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053954824.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053952908.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053946884.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_053961005.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_053967462.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053967487.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_053965300.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053945872.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Sodium/Calcium exchangers";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
XP_053969929.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053959414.1	4	Reactome: R-HSA-196757;KEGG: 00970+2.1.2.9;KEGG: 00670+1.5.1.6;KEGG: 00670+2.1.2.9	"Metabolism of folate and pterines";"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"One carbon pool by folate"
XP_053950999.1	6	Reactome: R-HSA-191859;Reactome: R-HSA-72165;Reactome: R-HSA-77588;Reactome: R-HSA-111367;Reactome: R-HSA-72163;Reactome: R-HSA-73856	"snRNP Assembly";"mRNA Splicing - Minor Pathway";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination"
XP_053950992.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_053956650.1	15	Reactome: R-HSA-70171;MetaCyc: PWY-7383;MetaCyc: PWY-5723;KEGG: 00010+2.7.1.40;MetaCyc: PWY-2221;MetaCyc: PWY-8004;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40;MetaCyc: PWY-7003;MetaCyc: PWY-1042;MetaCyc: PWY-6886;MetaCyc: PWY-6142;KEGG: 00620+2.7.1.40;MetaCyc: PWY-7218;MetaCyc: PWY-6901	"Glycolysis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Rubisco shunt";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Entner-Doudoroff pathway I";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism";"Glycerol degradation to butanol";"Glycolysis IV (plant cytosol)";"1-butanol autotrophic biosynthesis (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pyruvate metabolism";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Superpathway of glucose and xylose degradation"
XP_053947780.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053962086.1	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053951879.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053951701.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053956957.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053964790.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053952564.1	1	Reactome: R-HSA-419771	"Opsins"
XP_053953793.1	14	MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;MetaCyc: PWY-7411;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;MetaCyc: PWY-7589;MetaCyc: PWY-6453	"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Plasmalogen biosynthesis";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis"
XP_053967337.1	27	Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-4570464;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-5578749	"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"SUMOylation of RNA binding proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs"
XP_053954638.1	3	MetaCyc: PWY-2161B;KEGG: 00790+3.4.19.9;Reactome: R-HSA-6798695	"Glutamate removal from folates";"Folate biosynthesis";"Neutrophil degranulation"
XP_053960840.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053948557.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053960984.1	5	KEGG: 00760+6.3.4.21;Reactome: R-HSA-197264;Reactome: R-HSA-1368108;MetaCyc: PWY-5381;Reactome: R-HSA-6798695	"Nicotinate and nicotinamide metabolism";"Nicotinamide salvaging";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Pyridine nucleotide cycling (plants)";"Neutrophil degranulation"
XP_053953431.1	7	Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_053945081.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053952208.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_053960821.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053965890.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053948124.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053956904.1	25	Reactome: R-HSA-8939247;Reactome: R-HSA-8939246;Reactome: R-HSA-8941326;Reactome: R-HSA-8939902;Reactome: R-HSA-8939243;Reactome: R-HSA-8936459;Reactome: R-HSA-8939242;Reactome: R-HSA-8878166;Reactome: R-HSA-8951911;Reactome: R-HSA-8941284;Reactome: R-HSA-8934593;Reactome: R-HSA-8949275;Reactome: R-HSA-8939245;Reactome: R-HSA-8941332;Reactome: R-HSA-8940973;Reactome: R-HSA-8951936;Reactome: R-HSA-8935964;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-8939256;Reactome: R-HSA-9018519;Reactome: R-HSA-8941858;Reactome: R-HSA-8877330;Reactome: R-HSA-8941333;Reactome: R-HSA-8931987	"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX2 regulates bone development";"Regulation of RUNX2 expression and activity";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"Transcriptional regulation by RUNX2";"RUNX3 regulates RUNX1-mediated transcription";"RUNX2 regulates chondrocyte maturation";"Regulation of RUNX1 Expression and Activity";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX2 regulates genes involved in cell migration";"RUNX2 regulates osteoblast differentiation";"RUNX3 regulates p14-ARF";"RUNX1 regulates expression of components of tight junctions";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 regulates transcription of genes involved in WNT signaling";"Estrogen-dependent gene expression";"Regulation of RUNX3 expression and activity";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates estrogen receptor mediated transcription"
XP_053965946.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053958933.1	1	Reactome: R-HSA-5693565	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
XP_053950905.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053948731.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_053960996.1	56	Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-174154;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-69481;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-174184;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346	"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"G2/M Checkpoints";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Neddylation";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Degradation of AXIN";"Hedgehog ligand biogenesis"
XP_053946924.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053959317.1	5	Reactome: R-HSA-3270619;Reactome: R-HSA-6798695;Reactome: R-HSA-164843;Reactome: R-HSA-5693571;Reactome: R-HSA-1834949	"IRF3-mediated induction of type I IFN";"Neutrophil degranulation";"2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA"
XP_053963843.1	5	KEGG: 00520+2.6.1.16;KEGG: 00250+2.6.1.16;MetaCyc: PWY-8013;Reactome: R-HSA-446210;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"Alanine, aspartate and glutamate metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Synthesis of UDP-N-acetyl-glucosamine";"CMP-legionaminate biosynthesis I"
XP_053958104.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_053959926.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-390918	"Peroxisomal protein import";"Peroxisomal lipid metabolism"
XP_053953745.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053965418.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053952346.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053945534.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053945717.1	14	MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7036;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7619;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-8041;MetaCyc: PWY-7725	"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation";"Sciadonate biosynthesis";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)"
XP_053947273.1	4	MetaCyc: PWY-7927;KEGG: 00920+2.8.1.1;MetaCyc: PWY-5350;Reactome: R-HSA-1614558	"Sulfide oxidation IV (mitochondria)";"Sulfur metabolism";"Thiosulfate disproportionation IV (rhodanese)";"Degradation of cysteine and homocysteine"
XP_053969720.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053951923.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053960237.1	3	Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Estrogen-dependent gene expression";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053961341.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053963399.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053948787.1	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_053967434.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053955078.1	5	Reactome: R-HSA-8943724;Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-6804758	"Regulation of PTEN gene transcription";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"Regulation of TP53 Activity through Acetylation"
XP_053962453.1	13	MetaCyc: PWY-5123;MetaCyc: PWY-7709;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-7182;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-6859;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-7721;MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1	"Trans, trans-farnesyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Linalool biosynthesis I";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"All-trans-farnesol biosynthesis";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Methyl phomopsenoate biosynthesis";"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis"
XP_053961320.1	5	Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_053946072.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_053952702.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053948148.1	56	Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-9604323;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-69481;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-5689880;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-450408;Reactome: R-HSA-4608870	"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Negative regulation of NOTCH4 signaling";"Hedgehog 'on' state";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"G2/M Checkpoints";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"Ub-specific processing proteases";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Asymmetric localization of PCP proteins"
XP_053947967.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053969577.1	2	Reactome: R-HSA-6785470;Reactome: R-HSA-6784531	"tRNA processing in the mitochondrion";"tRNA processing in the nucleus"
XP_053970231.1	7	Reactome: R-HSA-212436;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-2173796	"Generic Transcription Pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"
XP_053959451.1	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
XP_053952743.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053946079.1	4	Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_053952709.1	5	Reactome: R-HSA-6798695;MetaCyc: PWY-7282;MetaCyc: PWY-7204;KEGG: 00750+2.7.1.35;Reactome: R-HSA-964975	"Neutrophil degranulation";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Pyridoxal 5'-phosphate salvage II (plants)";"Vitamin B6 metabolism";"Vitamins B6 activation to pyridoxal phosphate"
XP_053957399.1	13	Reactome: R-HSA-5099900;Reactome: R-HSA-416993;Reactome: R-HSA-3928665;Reactome: R-HSA-8964038;Reactome: R-HSA-8866427;Reactome: R-HSA-5140745;Reactome: R-HSA-2132295;Reactome: R-HSA-182218;Reactome: R-HSA-177504;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-167590;Reactome: R-HSA-437239	"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors";"EPH-ephrin mediated repulsion of cells";"LDL clearance";"VLDLR internalisation and degradation";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation";"Retrograde neurotrophin signalling";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Nef Mediated CD4 Down-regulation";"Recycling pathway of L1"
XP_053961555.1	6	Reactome: R-HSA-3769402;Reactome: R-HSA-8957275;Reactome: R-HSA-2173796;Reactome: R-HSA-5626467;Reactome: R-HSA-381426;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Post-translational protein phosphorylation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"RHO GTPases activate IQGAPs";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Formation of the beta-catenin:TCF transactivating complex"
XP_053968480.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053945084.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
XP_053956901.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053951757.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053948121.1	10	MetaCyc: PWY-7559;MetaCyc: PWY-5826;MetaCyc: PWY-7112;MetaCyc: PWY-6842;MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-4061;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041	"Glutathione degradation (DUG pathway";"Hypoglycin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification II";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Glutathione metabolism";"Glutathione-mediated detoxification I";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle"
XP_053969728.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_053958233.1	11	KEGG: 00561+3.1.3.4;Reactome: R-HSA-2029485;MetaCyc: PWY-8051;MetaCyc: PWY-8053;MetaCyc: PWY-8052;MetaCyc: PWY-8055;KEGG: 00565+3.1.3.4;KEGG: 00564+3.1.3.4;MetaCyc: PWY-6453;KEGG: 00600+3.1.3.4;MetaCyc: PWY-7782	"Glycerolipid metabolism";"Role of phospholipids in phagocytosis";"Anandamide biosynthesis I";"Anandamide biosynthesis II";"2-arachidonoylglycerol biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Ether lipid metabolism";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis";"Sphingolipid metabolism";"Plasmalogen biosynthesis"
XP_053955169.1	11	Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-163359;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555	"PKA activation in glucagon signalling";"Hedgehog 'off' state";"G alpha (i) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon signaling in metabolic regulation";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"G alpha (s) signalling events"
XP_053950205.1	7	Reactome: R-HSA-381042;Reactome: R-HSA-983170;Reactome: R-HSA-381183;Reactome: R-HSA-3371453;Reactome: R-HSA-381033;Reactome: R-HSA-114608;Reactome: R-HSA-381070	"PERK regulates gene expression";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"ATF6 (ATF6-alpha) activates chaperone genes";"Regulation of HSF1-mediated heat shock response";"ATF6 (ATF6-alpha) activates chaperones";"Platelet degranulation";"IRE1alpha activates chaperones"
XP_053965458.1	5	MetaCyc: PWY-7268;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23	"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_053952073.1	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
XP_053952539.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053952651.1	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
XP_053953434.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053960981.1	5	Reactome: R-HSA-197264;MetaCyc: PWY-5381;Reactome: R-HSA-1368108;KEGG: 00760+6.3.4.21;Reactome: R-HSA-6798695	"Nicotinamide salvaging";"Pyridine nucleotide cycling (plants)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinate and nicotinamide metabolism";"Neutrophil degranulation"
XP_053959357.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053947510.1	7	Reactome: R-HSA-1268020;MetaCyc: PWY-7980;Reactome: R-HSA-163210;KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;Reactome: R-HSA-2151201;Reactome: R-HSA-8949613	"Mitochondrial protein import";"ATP biosynthesis";"Formation of ATP by chemiosmotic coupling";"Photosynthesis";"Oxidative phosphorylation";"Transcriptional activation of mitochondrial biogenesis";"Cristae formation"
XP_053969889.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053957028.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053957547.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72649	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation"
XP_053957802.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053959304.1	4	MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32	"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism"
XP_053946306.1	2	Reactome: R-HSA-5339700;Reactome: R-HSA-4641265	"TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes"
XP_053961099.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053954848.1	1	Reactome: R-HSA-427652	"Sodium-coupled phosphate cotransporters"
XP_053969130.1	6	Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-4086398;Reactome: R-HSA-8951430;Reactome: R-HSA-4411364;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Ca2+ pathway";"RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex"
XP_053961092.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053945223.1	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
XP_053957843.1	8	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980;KEGG: 00195+7.1.2.2;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Oxidative phosphorylation";"ATP biosynthesis";"Photosynthesis";"Insulin receptor recycling";"Amino acids regulate mTORC1"
XP_053952696.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053960060.1	10	Reactome: R-HSA-2565942;Reactome: R-HSA-983168;Reactome: R-HSA-5684264;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-202424;Reactome: R-HSA-5607764;Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837	"Regulation of PLK1 Activity at G2/M Transition";"Antigen processing: Ubiquitination & Proteasome degradation";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Activation of NF-kappaB in B cells";"Neddylation";"Downstream TCR signaling";"CLEC7A (Dectin-1) signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation"
XP_053951014.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053964590.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_053963485.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053952059.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_053946851.1	11	Reactome: R-HSA-380972;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-9614657;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-163680;KEGG: 05165+2.7.11.1	"Energy dependent regulation of mTOR by LKB1-AMPK";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Human immunodeficiency virus 1 infection";"Thermogenesis";"FOXO-mediated transcription of cell death genes";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"AMPK inhibits chREBP transcriptional activation activity";"Human papillomavirus infection"
XP_053965338.1	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
XP_053967836.1	4	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053949690.1	5	MetaCyc: PWY-6527;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6317;KEGG: 00520+2.7.1.6	"Stachyose degradation";"Galactose metabolism";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism"
XP_053968025.1	2	Reactome: R-HSA-201722;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex"
XP_053947959.1	2	Reactome: R-HSA-5654726;Reactome: R-HSA-190373	"Negative regulation of FGFR1 signaling";"FGFR1c ligand binding and activation"
XP_053951140.1	13	MetaCyc: PWY-6969;MetaCyc: PWY-5392;KEGG: 00720+4.2.1.2;MetaCyc: PWY-5690;MetaCyc: PWY-5913;KEGG: 00020+4.2.1.2;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-7384;MetaCyc: PWY-7254;MetaCyc: PWY-561;KEGG: 00620+4.2.1.2;MetaCyc: PWY-8086	"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle VII (acetate-producers)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen"
XP_053948084.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053947952.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053952230.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_053968246.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_053967314.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053954600.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition"
XP_053969812.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_053949997.1	5	Reactome: R-HSA-5674400;Reactome: R-HSA-6804757;Reactome: R-HSA-5218920;Reactome: R-HSA-1257604;Reactome: R-HSA-389357	"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of TP53 Degradation";"VEGFR2 mediated vascular permeability";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling"
XP_053957335.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_053951121.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053969819.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-5627123	"Clathrin-mediated endocytosis";"RHO GTPases activate PAKs"
XP_053969683.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_053966915.1	13	KEGG: 00230+1.17.4.1;MetaCyc: PWY-7210;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7184;MetaCyc: PWY-7198;MetaCyc: PWY-7226;MetaCyc: PWY-7222;KEGG: 00480+1.17.4.1;KEGG: 00983+1.17.4.1;MetaCyc: PWY-6545;Reactome: R-HSA-499943;MetaCyc: PWY-7220	"Purine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Interconversion of nucleotide di- and triphosphates";"Adenosine deoxyribonucleotides de novo biosynthesis II"
XP_053965488.1	2	Reactome: R-HSA-70895;KEGG: 00280+1.1.1.31	"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation"
XP_053959362.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053949936.1	4	MetaCyc: PWY-6482;Reactome: R-HSA-8849175;MetaCyc: PWY-7546;Reactome: R-HSA-5358493	"Diphthamide biosynthesis I (archaea)";"Threonine catabolism";"Diphthamide biosynthesis II (eukaryotes)";"Synthesis of diphthamide-EEF2"
XP_053951054.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_053958721.1	11	Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-73776;Reactome: R-HSA-5689880;Reactome: R-HSA-6804756;Reactome: R-HSA-3214847;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-73779	"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Promoter Escape";"Ub-specific processing proteases";"Regulation of TP53 Activity through Phosphorylation";"HATs acetylate histones";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
XP_053949698.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053967307.1	11	Reactome: R-HSA-418597;Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-164378;Reactome: R-HSA-418594;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1	"G alpha (z) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"PKA activation in glucagon signalling";"G alpha (i) signalling events";"Hedgehog 'off' state";"PKA activation";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"Purine metabolism"
XP_053961585.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053948375.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_053969544.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053958740.1	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_053958078.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053951762.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053954608.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053960426.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_053956827.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053947252.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053952930.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053967897.1	2	Reactome: R-HSA-5576894;Reactome: R-HSA-1296072	"Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels"
XP_053952637.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053948534.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053959331.1	10	Reactome: R-HSA-3299685;Reactome: R-HSA-611105;Reactome: R-HSA-9627069;Reactome: R-HSA-111463;Reactome: R-HSA-111459;Reactome: R-HSA-111464;Reactome: R-HSA-111457;Reactome: R-HSA-111458;Reactome: R-HSA-2151201;Reactome: R-HSA-5628897	"Detoxification of Reactive Oxygen Species";"Respiratory electron transport";"Regulation of the apoptosome activity";"SMAC (DIABLO) binds to IAPs";"Activation of caspases through apoptosome-mediated cleavage";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Release of apoptotic factors from the mitochondria";"Formation of apoptosome";"Transcriptional activation of mitochondrial biogenesis";"TP53 Regulates Metabolic Genes"
XP_053952072.1	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
XP_053959005.1	5	Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-427413	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression"
XP_053969652.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_053953374.1	1	Reactome: R-HSA-70171	"Glycolysis"
XP_053952079.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_053967990.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053946871.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
XP_053958018.1	4	MetaCyc: PWY-7221;KEGG: 00983+6.3.5.2;Reactome: R-HSA-73817;KEGG: 00230+6.3.5.2	"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism"
XP_053961886.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053969531.1	12	MetaCyc: PWY-7901;KEGG: 00380+2.6.1.7;MetaCyc: PWY-801;MetaCyc: PWY-601;Reactome: R-HSA-71240;KEGG: 00450+4.4.1.13;MetaCyc: PWY-2821;MetaCyc: PWY-6936;MetaCyc: PWY-1187;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6309;MetaCyc: PWY-6842	"Glucosinolate biosynthesis from tyrosine";"Tryptophan metabolism";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from tryptophan";"Tryptophan catabolism";"Selenocompound metabolism";"Glucosinolate biosynthesis from phenylalanine";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from homomethionine";"Cysteine and methionine metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glutathione-mediated detoxification II"
XP_053950468.1	6	Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-380994	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress"
XP_053950026.1	12	Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-6807878;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257	"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"COPI-mediated anterograde transport";"HCMV Early Events";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion"
XP_053958232.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053961407.1	3	Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-5696400	"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Dual Incision in GG-NER"
XP_053954808.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2"
XP_053952924.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053963001.1	7	MetaCyc: PWY-6368;KEGG: 04070+3.1.3.36;KEGG: 00562+3.1.3.36;Reactome: R-HSA-1660499;Reactome: R-HSA-1855183;Reactome: R-HSA-8856828;Reactome: R-HSA-1855204	"3-phosphoinositide degradation";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of PIPs at the plasma membrane";"Synthesis of IP2, IP, and Ins in the cytosol";"Clathrin-mediated endocytosis";"Synthesis of IP3 and IP4 in the cytosol"
XP_053967705.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
XP_053945229.1	4	Reactome: R-HSA-1650814;Reactome: R-HSA-2243919;Reactome: R-HSA-1474228;Reactome: R-HSA-2214320	"Collagen biosynthesis and modifying enzymes";"Crosslinking of collagen fibrils";"Degradation of the extracellular matrix";"Anchoring fibril formation"
XP_053968478.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_053945744.1	5	Reactome: R-HSA-1655829;Reactome: R-HSA-5694530;Reactome: R-HSA-2132295;Reactome: R-HSA-983170;Reactome: R-HSA-204005	"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER";"MHC class II antigen presentation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"COPII-mediated vesicle transport"
XP_053963737.1	6	MetaCyc: PWY-7511;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-72163;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823	"Protein ubiquitination";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"mRNA Splicing - Major Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex"
XP_053957849.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053953535.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053951385.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053957507.1	13	Reactome: R-HSA-2022090;Reactome: R-HSA-419037;Reactome: R-HSA-3000157;Reactome: R-HSA-1442490;Reactome: R-HSA-3000178;Reactome: R-HSA-1474244;Reactome: R-HSA-2243919;Reactome: R-HSA-3000171;Reactome: R-HSA-186797;Reactome: R-HSA-216083;Reactome: R-HSA-2214320;Reactome: R-HSA-1650814;Reactome: R-HSA-8948216	"Assembly of collagen fibrils and other multimeric structures";"NCAM1 interactions";"Laminin interactions";"Collagen degradation";"ECM proteoglycans";"Extracellular matrix organization";"Crosslinking of collagen fibrils";"Non-integrin membrane-ECM interactions";"Signaling by PDGF";"Integrin cell surface interactions";"Anchoring fibril formation";"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization"
XP_053957842.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053945222.1	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
XP_053952881.1	3	KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1;Reactome: R-HSA-73843	"Purine metabolism";"Pentose phosphate pathway";"5-Phosphoribose 1-diphosphate biosynthesis"
XP_053946089.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053957664.1	2	Reactome: R-HSA-4086398;Reactome: R-HSA-418457	"Ca2+ pathway";"cGMP effects"
XP_053969569.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053949166.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053946082.1	4	Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex"
XP_053946067.1	2	Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2	"Signaling by SCF-KIT";"T cell receptor signaling pathway"
XP_053959785.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053955088.1	3	Reactome: R-HSA-1237112;KEGG: 00270+1.13.11.54;MetaCyc: PWY-4361	"Methionine salvage pathway";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053958058.1	15	Reactome: R-HSA-512988;Reactome: R-HSA-2219530;Reactome: R-HSA-389357;Reactome: R-HSA-6811558;Reactome: R-HSA-9009391;Reactome: R-HSA-114604;Reactome: R-HSA-416476;Reactome: R-HSA-912526;Reactome: R-HSA-1660499;Reactome: R-HSA-912631;Reactome: R-HSA-1257604;Reactome: R-HSA-388841;Reactome: R-HSA-8853659;Reactome: R-HSA-1433557;Reactome: R-HSA-1266695	"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"CD28 dependent PI3K/Akt signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Extra-nuclear estrogen signaling";"GPVI-mediated activation cascade";"G alpha (q) signalling events";"Interleukin receptor SHC signaling";"Synthesis of PIPs at the plasma membrane";"Regulation of signaling by CBL";"PIP3 activates AKT signaling";"Costimulation by the CD28 family";"RET signaling";"Signaling by SCF-KIT";"Interleukin-7 signaling"
XP_053955995.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053960119.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053970195.1	2	KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1	"Purine metabolism";"Pentose phosphate pathway"
XP_053963842.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053957514.1	14	MetaCyc: PWY-7411;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;MetaCyc: PWY-7589;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587	"Phosphatidate biosynthesis (yeast)";"Plasmalogen biosynthesis";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Glycerolipid metabolism";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)"
XP_053957001.1	11	Reactome: R-HSA-111457;Reactome: R-HSA-111459;Reactome: R-HSA-111464;Reactome: R-HSA-111458;Reactome: R-HSA-2151201;Reactome: R-HSA-5628897;Reactome: R-HSA-3299685;Reactome: R-HSA-1268020;Reactome: R-HSA-611105;Reactome: R-HSA-111463;Reactome: R-HSA-9627069	"Release of apoptotic factors from the mitochondria";"Activation of caspases through apoptosome-mediated cleavage";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Formation of apoptosome";"Transcriptional activation of mitochondrial biogenesis";"TP53 Regulates Metabolic Genes";"Detoxification of Reactive Oxygen Species";"Mitochondrial protein import";"Respiratory electron transport";"SMAC (DIABLO) binds to IAPs";"Regulation of the apoptosome activity"
XP_053957737.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053967290.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053953705.1	5	Reactome: R-HSA-168164;Reactome: R-HSA-166166;Reactome: R-HSA-936964;Reactome: R-HSA-937072;Reactome: R-HSA-937041	"Toll Like Receptor 3 (TLR3) Cascade";"MyD88-independent TLR4 cascade";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IKK complex recruitment mediated by RIP1"
XP_053958144.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053958939.1	5	Reactome: R-HSA-9020702;Reactome: R-HSA-5205685;Reactome: R-HSA-209543;Reactome: R-HSA-209560;Reactome: R-HSA-205043	"Interleukin-1 signaling";"Pink/Parkin Mediated Mitophagy";"p75NTR recruits signalling complexes";"NF-kB is activated and signals survival";"NRIF signals cell death from the nucleus"
XP_053948528.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6798695	"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation"
XP_053955080.1	5	Reactome: R-HSA-6804758;Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815	"Regulation of TP53 Activity through Acetylation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"Regulation of PTEN gene transcription";"HDACs deacetylate histones"
XP_053962395.1	16	Reactome: R-HSA-1257604;Reactome: R-HSA-1810476;Reactome: R-HSA-975138;Reactome: R-HSA-5603041;Reactome: R-HSA-975871;Reactome: R-HSA-975110;Reactome: R-HSA-209543;Reactome: R-HSA-5602498;Reactome: R-HSA-975155;Reactome: R-HSA-166058;Reactome: R-HSA-6811558;Reactome: R-HSA-3134963;Reactome: R-HSA-9020702;Reactome: R-HSA-1236974;Reactome: R-HSA-5603037;Reactome: R-HSA-5602680	"PIP3 activates AKT signaling";"RIP-mediated NFkB activation via ZBP1";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"IRAK4 deficiency (TLR2/4)";"MyD88 cascade initiated on plasma membrane";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"p75NTR recruits signalling complexes";"MyD88 deficiency (TLR2/4)";"MyD88 dependent cascade initiated on endosome";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"Interleukin-1 signaling";"ER-Phagosome pathway";"IRAK4 deficiency (TLR5)";"MyD88 deficiency (TLR5)"
XP_053958932.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_053946561.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_053949890.1	6	MetaCyc: PWY-7761;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807;MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1	"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism"
XP_053947151.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_053962452.1	13	MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-6859;MetaCyc: PWY-7721;MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-5123;MetaCyc: PWY-7709;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-7182;MetaCyc: PWY-7141;MetaCyc: PWY-7736	"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"All-trans-farnesol biosynthesis";"Methyl phomopsenoate biosynthesis";"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"Linalool biosynthesis I";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis"
XP_053967998.1	3	Reactome: R-HSA-5689877;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394	"Josephin domain DUBs";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER"
XP_053952224.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions"
XP_053946073.1	2	Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2	"Signaling by SCF-KIT";"T cell receptor signaling pathway"
XP_053952703.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053962459.1	13	MetaCyc: PWY-7709;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7182;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-5123;MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-6383;MetaCyc: PWY-5122;MetaCyc: PWY-6859;MetaCyc: PWY-7721	"(3R)-linalool biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"Linalool biosynthesis I";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"All-trans-farnesol biosynthesis";"Methyl phomopsenoate biosynthesis"
XP_053952742.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053946539.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053946651.1	3	Reactome: R-HSA-2468052;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257	"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion"
XP_053964116.1	3	Reactome: R-HSA-8875656;Reactome: R-HSA-8854214;Reactome: R-HSA-8856828	"MET receptor recycling";"TBC/RABGAPs";"Clathrin-mediated endocytosis"
XP_053952168.1	3	KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029;MetaCyc: PWY-7221	"Purine metabolism";"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis"
XP_053951922.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053951435.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053947279.1	1	Reactome: R-HSA-419771	"Opsins"
XP_053961414.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_053952896.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053957609.1	1	KEGG: 00240+3.1.3.89	"Pyrimidine metabolism"
XP_053963475.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053945108.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053958700.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_053948435.1	10	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-437239;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-444257;KEGG: 04151+2.7.11.1;Reactome: R-HSA-442742;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Recycling pathway of L1";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"RSK activation";"PI3K-Akt signaling pathway";"CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling";"Human papillomavirus infection"
XP_053969960.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053970161.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_053951499.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053961865.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053953420.1	7	Reactome: R-HSA-1855183;MetaCyc: PWY-4702;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.25;KEGG: 04070+3.1.3.25;KEGG: 00521+3.1.3.25;MetaCyc: PWY-2301	"Synthesis of IP2, IP, and Ins in the cytosol";"Phytate degradation I";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Streptomycin biosynthesis";"Myo-inositol biosynthesis"
XP_053962361.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053969689.1	2	Reactome: R-HSA-6798695;MetaCyc: PWY-7511	"Neutrophil degranulation";"Protein ubiquitination"
XP_053951528.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053969268.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism"
XP_053961484.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
XP_053965470.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_053948074.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053959755.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_053969853.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053958995.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053946696.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053947253.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053956522.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053951047.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_053958080.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053962645.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053945541.1	3	Reactome: R-HSA-8963684;Reactome: R-HSA-156590;Reactome: R-HSA-204174	"Tyrosine catabolism";"Glutathione conjugation";"Regulation of pyruvate dehydrogenase (PDH) complex"
XP_053969051.1	5	MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.10;KEGG: 00230+2.7.4.3	"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Purine metabolism";"Purine metabolism"
XP_053963711.1	3	Reactome: R-HSA-9609523;Reactome: R-HSA-1799339;Reactome: R-HSA-1236974	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"SRP-dependent cotranslational protein targeting to membrane";"ER-Phagosome pathway"
XP_053947137.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053969260.1	5	Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68962	"Assembly of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"Activation of the pre-replicative complex"
XP_053955261.1	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_053945777.1	2	Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_053945520.1	7	KEGG: 00010+1.2.4.1;Reactome: R-HSA-5362517;KEGG: 00020+1.2.4.1;Reactome: R-HSA-389661;Reactome: R-HSA-204174;Reactome: R-HSA-70268;KEGG: 00620+1.2.4.1	"Glycolysis / Gluconeogenesis";"Signaling by Retinoic Acid";"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Pyruvate metabolism"
XP_053961816.1	17	Reactome: R-HSA-5358606;Reactome: R-HSA-5358565;Reactome: R-HSA-69166;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-5685942;Reactome: R-HSA-174437;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-69091;Reactome: R-HSA-6782135;Reactome: R-HSA-174417;Reactome: R-HSA-174414;Reactome: R-HSA-5696400;Reactome: R-HSA-69183;Reactome: R-HSA-110314	"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Removal of the Flap Intermediate";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate from the C-strand";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching";"Dual incision in TC-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Processive synthesis on the C-strand of the telomere";"Dual Incision in GG-NER";"Processive synthesis on the lagging strand";"Recognition of DNA damage by PCNA-containing replication complex"
XP_053953592.1	29	Reactome: R-HSA-6782135;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-5358565;Reactome: R-HSA-69166;Reactome: R-HSA-5651801;Reactome: R-HSA-110312;Reactome: R-HSA-5696400;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-110314;Reactome: R-HSA-5693607;Reactome: R-HSA-5656121;Reactome: R-HSA-6783310;Reactome: R-HSA-912446;Reactome: R-HSA-5358606;Reactome: R-HSA-5696395;Reactome: R-HSA-3108214;Reactome: R-HSA-174437;Reactome: R-HSA-6782210;Reactome: R-HSA-5685942;Reactome: R-HSA-3371453;Reactome: R-HSA-3371511;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-5655862;Reactome: R-HSA-110320	"Dual incision in TC-NER";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Removal of the Flap Intermediate";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by REV1";"Dual Incision in GG-NER";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Recognition of DNA damage by PCNA-containing replication complex";"Processing of DNA double-strand break ends";"Translesion synthesis by POLI";"Fanconi Anemia Pathway";"Meiotic recombination";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Formation of Incision Complex in GG-NER";"SUMOylation of DNA damage response and repair proteins";"Removal of the Flap Intermediate from the C-strand";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HDR through Homologous Recombination (HRR)";"Regulation of HSF1-mediated heat shock response";"HSF1 activation";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Translesion synthesis by POLK";"Translesion Synthesis by POLH"
XP_053948385.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053951541.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053946930.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053947860.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-6798695	"Neddylation";"Neutrophil degranulation"
XP_053947578.1	2	KEGG: 00380+1.13.11.11;Reactome: R-HSA-71240	"Tryptophan metabolism";"Tryptophan catabolism"
XP_053959715.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053953347.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053969813.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_053957751.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053946012.1	5	KEGG: 00720+4.2.1.3;KEGG: 00630+4.2.1.3;KEGG: 00020+4.2.1.3;KEGG: 00290+4.2.1.33;Reactome: R-HSA-917937	"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism";"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine biosynthesis";"Iron uptake and transport"
XP_053954640.1	3	KEGG: 00790+3.4.19.9;MetaCyc: PWY-2161B;Reactome: R-HSA-6798695	"Folate biosynthesis";"Glutamate removal from folates";"Neutrophil degranulation"
XP_053969734.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_053960838.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053946019.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053962467.1	3	Reactome: R-HSA-70268;KEGG: 00620+4.4.1.5;MetaCyc: PWY-5386	"Pyruvate metabolism";"Pyruvate metabolism";"Methylglyoxal degradation I"
XP_053946681.1	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
XP_053947953.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_053948728.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_053955120.1	4	KEGG: 00513+2.4.1.131;Reactome: R-HSA-4551295;KEGG: 00510+2.4.1.131;Reactome: R-HSA-446193	"Various types of N-glycan biosynthesis";"Defective ALG11 causes ALG11-CDG (CDG-1p)";"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
XP_053952397.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053951812.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053959474.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053952854.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053946476.1	15	KEGG: 00010+2.7.1.40;MetaCyc: PWY-5723;MetaCyc: PWY-7383;Reactome: R-HSA-70171;MetaCyc: PWY-8004;MetaCyc: PWY-2221;MetaCyc: PWY-6886;MetaCyc: PWY-1042;KEGG: 00230+2.7.1.40;MetaCyc: PWY-7003;MetaCyc: PWY-5484;MetaCyc: PWY-6901;KEGG: 00620+2.7.1.40;MetaCyc: PWY-7218;MetaCyc: PWY-6142	"Glycolysis / Gluconeogenesis";"Rubisco shunt";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis";"Entner-Doudoroff pathway I";"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Purine metabolism";"Glycerol degradation to butanol";"Glycolysis II (from fructose 6-phosphate)";"Superpathway of glucose and xylose degradation";"Pyruvate metabolism";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
XP_053945812.1	1	Reactome: R-HSA-163765	"ChREBP activates metabolic gene expression"
XP_053961481.1	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
XP_053965175.1	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
XP_053969140.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053954838.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053963031.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053957581.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053963695.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053952486.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053963087.1	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
XP_053945679.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053948130.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_053969014.1	16	Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-8934593;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-5628897;Reactome: R-HSA-8986944;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-2559585;Reactome: R-HSA-8943723;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884	"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by MECP2";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oncogene Induced Senescence";"Regulation of PTEN mRNA translation";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX"
XP_053970164.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053952542.1	6	Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156827	"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_053953606.1	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_053957087.1	16	Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-975957	"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053963581.1	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
XP_053956977.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053951859.1	19	Reactome: R-HSA-114604;Reactome: R-HSA-525793;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5626467;Reactome: R-HSA-8964616;Reactome: R-HSA-5627123;Reactome: R-HSA-3928662;Reactome: R-HSA-983231;Reactome: R-HSA-5625970;Reactome: R-HSA-8950505;Reactome: R-HSA-389359;Reactome: R-HSA-5687128;Reactome: R-HSA-5663213;Reactome: R-HSA-182971;Reactome: R-HSA-5663220;Reactome: R-HSA-418885;Reactome: R-HSA-428543;Reactome: R-HSA-194840	"GPVI-mediated activation cascade";"Myogenesis";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases activate IQGAPs";"G beta:gamma signalling through CDC42";"RHO GTPases activate PAKs";"EPHB-mediated forward signaling";"Factors involved in megakaryocyte development and platelet production";"RHO GTPases activate KTN1";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"CD28 dependent Vav1 pathway";"MAPK6/MAPK4 signaling";"RHO GTPases Activate WASPs and WAVEs";"EGFR downregulation";"RHO GTPases Activate Formins";"DCC mediated attractive signaling";"Inactivation of CDC42 and RAC1";"Rho GTPase cycle"
XP_053946502.1	9	Reactome: R-HSA-3642279;Reactome: R-HSA-2173788;Reactome: R-HSA-5689603;Reactome: R-HSA-3304356;Reactome: R-HSA-3656532;Reactome: R-HSA-3645790;Reactome: R-HSA-2173791;Reactome: R-HSA-2173789;Reactome: R-HSA-3656535	"TGFBR2 MSI Frameshift Mutants in Cancer";"Downregulation of TGF-beta receptor signaling";"UCH proteinases";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"TGFBR2 Kinase Domain Mutants in Cancer";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGF-beta receptor signaling activates SMADs";"TGFBR1 LBD Mutants in Cancer"
XP_053945859.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
XP_053957754.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053946543.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_053957170.1	11	Reactome: R-HSA-163359;Reactome: R-HSA-170670;Reactome: R-HSA-163615;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-418594	"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway";"PKA activation";"Purine metabolism";"G alpha (s) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"G alpha (i) signalling events"
XP_053965297.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053956858.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053969731.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053947622.1	3	KEGG: 00250+3.5.1.1;Reactome: R-HSA-8964208;KEGG: 00460+3.5.1.1	"Alanine, aspartate and glutamate metabolism";"Phenylalanine metabolism";"Cyanoamino acid metabolism"
XP_053946129.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_053954189.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053969493.1	16	Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053951544.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053955128.1	2	Reactome: R-HSA-8866907;Reactome: R-HSA-8866904	"Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors"
XP_053959585.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257	"RHO GTPases Activate Formins";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion"
XP_053946122.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053948720.1	2	Reactome: R-HSA-8951671;Reactome: R-HSA-2032785	"RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression"
XP_053954182.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053961387.1	12	MetaCyc: PWY-6122;MetaCyc: PWY-6121;KEGG: 00670+2.1.2.2;Reactome: R-HSA-196780;KEGG: 00970+2.1.2.9;MetaCyc: PWY-6277;Reactome: R-HSA-73817;KEGG: 00230+6.3.4.13;KEGG: 00230+2.1.2.2;MetaCyc: PWY-6613;KEGG: 00230+6.3.3.1;KEGG: 00670+2.1.2.9	"5-aminoimidazole ribonucleotide biosynthesis II";"5-aminoimidazole ribonucleotide biosynthesis I";"One carbon pool by folate";"Biotin transport and metabolism";"Aminoacyl-tRNA biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Purine metabolism";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine metabolism";"One carbon pool by folate"
XP_053967505.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_053960648.1	9	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-1368082;Reactome: R-HSA-2151201;Reactome: R-HSA-400253;Reactome: R-HSA-2426168;Reactome: R-HSA-5617472;Reactome: R-HSA-400206;Reactome: R-HSA-1368108	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"RORA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"Circadian Clock";"Activation of gene expression by SREBF (SREBP)";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of lipid metabolism by PPARalpha";"BMAL1:CLOCK,NPAS2 activates circadian gene expression"
XP_053954830.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053955264.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_053957707.1	56	Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-174184;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-180585	"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"Neddylation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G"
XP_053948741.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053964460.1	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
XP_053957661.1	14	Reactome: R-HSA-9648025;Reactome: R-HSA-9634638;Reactome: R-HSA-69273;Reactome: R-HSA-3769402;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-165054;Reactome: R-HSA-68877;Reactome: R-HSA-5687128;Reactome: R-HSA-2173788;Reactome: R-HSA-5663220;Reactome: R-HSA-450520;Reactome: R-HSA-168333;Reactome: R-HSA-141444	"EML4 and NUDC in mitotic spindle formation";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Cyclin A/B1/B2 associated events during G2/M transition";"Deactivation of the beta-catenin transactivating complex";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Rev-mediated nuclear export of HIV RNA";"Mitotic Prometaphase";"MAPK6/MAPK4 signaling";"Downregulation of TGF-beta receptor signaling";"RHO GTPases Activate Formins";"HuR (ELAVL1) binds and stabilizes mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_053945720.1	14	MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-5972	"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)"
XP_053946908.1	14	Reactome: R-HSA-9017802;Reactome: R-HSA-1474228;Reactome: R-HSA-193692;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700;Reactome: R-HSA-3928665;Reactome: R-HSA-205043;Reactome: R-HSA-6798695;Reactome: R-HSA-2644606;Reactome: R-HSA-977225;Reactome: R-HSA-2894862	"Noncanonical activation of NOTCH3";"Degradation of the extracellular matrix";"Regulated proteolysis of p75NTR";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"EPH-ephrin mediated repulsion of cells";"NRIF signals cell death from the nucleus";"Neutrophil degranulation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Amyloid fiber formation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053953792.1	14	MetaCyc: PWY-8053;MetaCyc: PWY-5667;MetaCyc: PWY-7417;KEGG: 00564+2.3.1.51;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51	"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Synthesis of PA";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism"
XP_053951873.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_053946614.1	4	KEGG: 00564+3.1.1.32;KEGG: 00592+3.1.1.32;MetaCyc: PWY-6803;MetaCyc: PWY-8051	"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I"
XP_053945741.1	4	Reactome: R-HSA-8943724;Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-73762	"Regulation of PTEN gene transcription";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation"
XP_053945873.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053962309.1	6	Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_053952921.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053969375.1	2	Reactome: R-HSA-8981607;Reactome: R-HSA-203615	"Intracellular oxygen transport";"eNOS activation"
XP_053965340.1	4	Reactome: R-HSA-3214847;MetaCyc: PWY-7437;Reactome: R-HSA-5689603;KEGG: 00514+2.4.1.255	"HATs acetylate histones";"Protein O-[N-acetyl]-glucosylation";"UCH proteinases";"Other types of O-glycan biosynthesis"
XP_053950993.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_053947114.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053947021.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053949946.1	14	KEGG: 00290+2.6.1.42;MetaCyc: PWY-7767;MetaCyc: PWY-5104;MetaCyc: PWY-5078;MetaCyc: PWY-5057;MetaCyc: PWY-5101;MetaCyc: PWY-5076;Reactome: R-HSA-70895;MetaCyc: PWY-5108;KEGG: 00270+2.6.1.42;KEGG: 00280+2.6.1.42;KEGG: 00770+2.6.1.42;KEGG: 00966+2.6.1.42;MetaCyc: PWY-5103	"Valine, leucine and isoleucine biosynthesis";"L-leucine degradation IV (Stickland reaction)";"L-isoleucine biosynthesis IV";"L-isoleucine degradation II";"L-valine degradation II";"L-isoleucine biosynthesis II";"L-leucine degradation III";"Branched-chain amino acid catabolism";"L-isoleucine biosynthesis V";"Cysteine and methionine metabolism";"Valine, leucine and isoleucine degradation";"Pantothenate and CoA biosynthesis";"Glucosinolate biosynthesis";"L-isoleucine biosynthesis III"
XP_053961317.1	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
XP_053961926.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053963784.1	31	MetaCyc: PWY-5994;MetaCyc: PWY-7388;Reactome: R-HSA-75105;MetaCyc: PWY-8047;MetaCyc: PWY-5147;MetaCyc: PWY-6282;MetaCyc: PWY-8012;MetaCyc: PWY-7746;MetaCyc: PWY-5989;MetaCyc: PWY-5366;MetaCyc: PWY-5973;MetaCyc: PWY-7664;MetaCyc: PWY-5367;Reactome: R-HSA-199220;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-7663;MetaCyc: PWY-6113;MetaCyc: PWY-5142;MetaCyc: PWY-7858;MetaCyc: PWY-6519;MetaCyc: PWYG-321;MetaCyc: PWY-5971;Reactome: R-HSA-9029558;Reactome: R-HSA-2426168;MetaCyc: PWY-5966-1;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7723;MetaCyc: PWY-4381;Reactome: R-HSA-163765;MetaCyc: PWY-6799;MetaCyc: PWY-8049	"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acyl-CoA biosynthesis";"Bryostatin biosynthesis";"Oleate biosynthesis I (plants)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Mupirocin biosynthesis";"Mycobacterial sulfolipid biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Palmitoleate biosynthesis II (plants and bacteria)";"Cis-vaccenate biosynthesis";"Oleate biosynthesis IV (anaerobic)";"Petroselinate biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Fatty acid biosynthesis";"Gondoate biosynthesis (anaerobic)";"Superpathway of mycolate biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"(5Z)-dodecenoate biosynthesis II";"8-amino-7-oxononanoate biosynthesis I";"";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Biotin metabolism";"Bacterial bioluminescence";"Fatty acid biosynthesis initiation (bacteria and plants)";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (plant mitochondria)";"Pederin biosynthesis"
XP_053952248.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053946200.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053948405.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053959515.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053947778.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053962746.1	8	Reactome: R-HSA-71336;Reactome: R-HSA-6791055;MetaCyc: PWY-5723;MetaCyc: PWY-1861;Reactome: R-HSA-6791462;Reactome: R-HSA-163754;KEGG: 00030+2.2.1.2;Reactome: R-HSA-8950505	"Pentose phosphate pathway";"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P";"Rubisco shunt";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P";"Insulin effects increased synthesis of Xylulose-5-Phosphate";"Pentose phosphate pathway";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_053958730.1	5	MetaCyc: PWY-6855;Reactome: R-HSA-70171;MetaCyc: PWY-6906;MetaCyc: PWY-5514;KEGG: 00520+3.5.99.6	"Chitin degradation I (archaea)";"Glycolysis";"Chitin derivatives degradation";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Amino sugar and nucleotide sugar metabolism"
XP_053968297.1	12	KEGG: 00010+4.1.2.13;KEGG: 00030+4.1.2.13;KEGG: 00680+4.1.2.13;Reactome: R-HSA-70171;MetaCyc: PWY-6142;KEGG: 00051+4.1.2.13;MetaCyc: PWY-5484;KEGG: 00710+4.1.2.13;MetaCyc: PWY-1861;MetaCyc: PWY-1042;Reactome: R-HSA-70263;MetaCyc: PWY-7385	"Glycolysis / Gluconeogenesis";"Pentose phosphate pathway";"Methane metabolism";"Glycolysis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis IV (plant cytosol)";"Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)"
XP_053948852.1	6	Reactome: R-HSA-69473;Reactome: R-HSA-176187;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938	"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)"
XP_053954119.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053969534.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_053958508.1	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
XP_053957632.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053963057.1	1	Reactome: R-HSA-912446	"Meiotic recombination"
XP_053969717.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053946795.1	5	Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-72163	"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Major Pathway"
XP_053957784.1	5	Reactome: R-HSA-1834949;Reactome: R-HSA-5693571;Reactome: R-HSA-164843;Reactome: R-HSA-6798695;Reactome: R-HSA-3270619	"Cytosolic sensors of pathogen-associated DNA";"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation";"Neutrophil degranulation";"IRF3-mediated induction of type I IFN"
XP_053961304.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053959099.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053956888.1	12	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-418885;Reactome: R-HSA-194840;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-416476;Reactome: R-HSA-193648	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"G alpha (12/13) signalling events";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"DCC mediated attractive signaling";"Rho GTPase cycle";"Relaxin signaling pathway";"Human cytomegalovirus infection";"G alpha (q) signalling events";"NRAGE signals death through JNK"
XP_053959665.1	20	MetaCyc: PWY-7288;KEGG: 00071+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7854;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-6920;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-6837;MetaCyc: PWY-7291;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-7338;MetaCyc: PWY-7858;MetaCyc: PWY-7007;KEGG: 00410+1.3.3.6	"Fatty acid beta-oxidation VII (yeast peroxisome)";"Fatty acid degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"Peroxisomal protein import";"6-gingerol analog biosynthesis (engineered)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"Methyl ketone biosynthesis (engineered)";"beta-Alanine metabolism"
XP_053945867.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-425561	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Sodium/Calcium exchangers"
XP_053950165.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053955209.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053951867.1	6	Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation"
XP_053951882.1	8	Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Activation of RAC1";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053958500.1	5	Reactome: R-HSA-2871796;Reactome: R-HSA-450321;Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2559580	"FCERI mediated MAPK activation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"mTOR signaling pathway";"Oxidative Stress Induced Senescence"
XP_053963632.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950156.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_053959656.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053951889.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053948679.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_053951563.1	14	KEGG: 00561+2.3.1.51;MetaCyc: PWY-7587;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-5981;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-7417;MetaCyc: PWY-5667;MetaCyc: PWY-8053;KEGG: 00564+2.3.1.51	"Glycerolipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis III";"Plasmalogen biosynthesis";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis II";"Glycerophospholipid metabolism"
XP_053960808.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053969223.1	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440	"RAB GEFs exchange GTP for GDP on RABs";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network"
XP_053961357.1	24	Reactome: R-HSA-5610785;Reactome: R-HSA-180024;Reactome: R-HSA-9634600;Reactome: R-HSA-5621575;Reactome: R-HSA-9010642;Reactome: R-HSA-8963896;Reactome: R-HSA-163615;Reactome: R-HSA-111931;Reactome: R-HSA-983231;Reactome: R-HSA-163358;Reactome: R-HSA-392517;KEGG: 04150+2.7.11.11;Reactome: R-HSA-163560;Reactome: R-HSA-4420097;Reactome: R-HSA-381676;Reactome: R-HSA-5610783;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-8853659;Reactome: R-HSA-422356;Reactome: R-HSA-442720;Reactome: R-HSA-432040	"GLI3 is processed to GLI3R by the proteasome";"DARPP-32 events";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"CD209 (DC-SIGN) signaling";"ROBO receptors bind AKAP5";"HDL assembly";"PKA activation";"PKA-mediated phosphorylation of CREB";"Factors involved in megakaryocyte development and platelet production";"PKA-mediated phosphorylation of key metabolic factors";"Rap1 signalling";"mTOR signaling pathway";"Triglyceride catabolism";"VEGFA-VEGFR2 Pathway";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Degradation of GLI2 by the proteasome";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"RET signaling";"Regulation of insulin secretion";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins"
XP_053956729.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_053961045.1	5	Reactome: R-HSA-3214815;Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606	"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_053959328.1	22	Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-5673000;Reactome: R-HSA-2500257;Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-6811558;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5358751	"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RAF activation";"Resolution of Sister Chromatid Cohesion";"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated"
XP_053967463.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053946900.1	6	KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952;Reactome: R-HSA-975578;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7920;MetaCyc: PWY-7426	"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Reactions specific to the complex N-glycan synthesis pathway";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (plants)";"Complex N-linked glycan biosynthesis (vertebrates)"
XP_053961226.1	4	Reactome: R-HSA-5250958;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361	"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Neurexins and neuroligins"
XP_053949025.1	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
XP_053945728.1	14	MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7619	"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis"
XP_053964468.1	3	Reactome: R-HSA-3214858;Reactome: R-HSA-6804760;Reactome: R-HSA-191859	"RMTs methylate histone arginines";"Regulation of TP53 Activity through Methylation";"snRNP Assembly"
XP_053951728.1	6	Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72706	"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_053967846.1	3	MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2;Reactome: R-HSA-1650814	"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism";"Collagen biosynthesis and modifying enzymes"
XP_053965348.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053948819.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053963017.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053959447.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053950967.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053952005.1	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
XP_053962652.1	20	MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;Reactome: R-HSA-163765;KEGG: 00020+2.3.3.8;KEGG: 00660+6.2.1.5;Reactome: R-HSA-1268020;MetaCyc: PWY-7384;MetaCyc: PWY-6728;Reactome: R-HSA-71403;Reactome: R-HSA-6798695;MetaCyc: PWY-5913;MetaCyc: PWY-5172;MetaCyc: PWY-5537;MetaCyc: PWY-5690;Reactome: R-HSA-75105;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-6969;KEGG: 00720+2.3.3.8	"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"ChREBP activates metabolic gene expression";"Citrate cycle (TCA cycle)";"C5-Branched dibasic acid metabolism";"Mitochondrial protein import";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Neutrophil degranulation";"Partial TCA cycle (obligate autotrophs)";"Acetyl-coa biosynthesis III (from citrate)";"Pyruvate fermentation to acetate V";"TCA cycle II (plants and fungi)";"Fatty acyl-CoA biosynthesis";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes"
XP_053967436.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053950989.1	1	Reactome: R-HSA-203615	"eNOS activation"
XP_053950518.1	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
XP_053962659.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053964780.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_053962096.1	7	KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway"
XP_053951091.1	6	MetaCyc: PWY-6124;Reactome: R-HSA-73817;MetaCyc: PWY-7234;MetaCyc: PWY-6123;KEGG: 00230+4.1.1.21;KEGG: 00230+6.3.2.6	"Inosine-5'-phosphate biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Purine metabolism"
XP_053946926.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053967772.1	4	Reactome: R-HSA-912631;Reactome: R-HSA-8875656;Reactome: R-HSA-8875555;Reactome: R-HSA-186763	"Regulation of signaling by CBL";"MET receptor recycling";"MET activates RAP1 and RAC1";"Downstream signal transduction"
XP_053954986.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053960378.1	42	Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5334118;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-912446;Reactome: R-HSA-9018519;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-427413;Reactome: R-HSA-2299718;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-3214842;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Packaging Of Telomere Ends";"Meiotic synapsis";"DNA methylation";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"Meiotic recombination";"Estrogen-dependent gene expression";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"HDMs demethylate histones";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of chromatin organization proteins";"HCMV Late Events"
XP_053965132.1	8	Reactome: R-HSA-68867;Reactome: R-HSA-68827;Reactome: R-HSA-68616;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-68949;Reactome: R-HSA-176187	"Assembly of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress"
XP_053961200.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_053967801.1	3	Reactome: R-HSA-6783984;KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"Glycine degradation";"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_053950550.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_053952344.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053968670.1	4	Reactome: R-HSA-983231;Reactome: R-HSA-2586552;Reactome: R-HSA-1170546;Reactome: R-HSA-982772	"Factors involved in megakaryocyte development and platelet production";"Signaling by Leptin";"Prolactin receptor signaling";"Growth hormone receptor signaling"
XP_053945536.1	2	Reactome: R-HSA-196819;KEGG: 00230+4.6.1.1	"Vitamin B1 (thiamin) metabolism";"Purine metabolism"
XP_053965139.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053962883.1	34	Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-180910;Reactome: R-HSA-9639288;Reactome: R-HSA-9648025;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-168333;Reactome: R-HSA-141444	"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Vpr-mediated nuclear import of PICs";"Amino acids regulate mTORC1";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_053953779.1	2	MetaCyc: PWY-5386;KEGG: 00620+3.1.2.6	"Methylglyoxal degradation I";"Pyruvate metabolism"
XP_053964008.1	3	Reactome: R-HSA-3214858;Reactome: R-HSA-191859;Reactome: R-HSA-6804760	"RMTs methylate histone arginines";"snRNP Assembly";"Regulation of TP53 Activity through Methylation"
XP_053959306.1	4	KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32;MetaCyc: PWY-6803;MetaCyc: PWY-8051	"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I"
XP_053950558.1	6	Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-429958;Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_053962619.1	3	Reactome: R-HSA-5656121;Reactome: R-HSA-110312;Reactome: R-HSA-5655862	"Translesion synthesis by POLI";"Translesion synthesis by REV1";"Translesion synthesis by POLK"
XP_053945706.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053950289.1	10	MetaCyc: PWY-5826;MetaCyc: PWY-7559;MetaCyc: PWY-7112;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-4061;MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;MetaCyc: PWY-6842;MetaCyc: PWY-4041;KEGG: 00460+2.3.2.2	"Hypoglycin biosynthesis";"Glutathione degradation (DUG pathway";"4-hydroxy-2-nonenal detoxification";"Glutathione metabolism";"Glutathione-mediated detoxification I";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Glutathione-mediated detoxification II";"Gamma-glutamyl cycle";"Cyanoamino acid metabolism"
XP_053962612.1	8	KEGG: 00051+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00010+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00520+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00052+2.7.1.1	"Fructose and mannose metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Glycolysis / Gluconeogenesis";"Glycolysis";"Amino sugar and nucleotide sugar metabolism";"Streptomycin biosynthesis";"Starch and sucrose metabolism";"Galactose metabolism"
XP_053945893.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_053962081.1	2	KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
XP_053964829.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053969395.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053945597.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_053959703.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053962701.1	4	Reactome: R-HSA-1614558;KEGG: 00270+1.13.11.20;KEGG: 00430+1.13.11.20;MetaCyc: PWY-5331	"Degradation of cysteine and homocysteine";"Cysteine and methionine metabolism";"Taurine and hypotaurine metabolism";"Taurine biosynthesis I"
XP_053954991.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053953436.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053962037.1	6	KEGG: 04070+2.7.11.13;Reactome: R-HSA-114516;Reactome: R-HSA-418597;Reactome: R-HSA-76005;Reactome: R-HSA-5099900;Reactome: R-HSA-416993	"Phosphatidylinositol signaling system";"Disinhibition of SNARE formation";"G alpha (z) signalling events";"Response to elevated platelet cytosolic Ca2+";"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors"
XP_053968818.1	6	KEGG: 00730+2.7.6.2;Reactome: R-HSA-196819;MetaCyc: PWY-6908;MetaCyc: PWY-6898;MetaCyc: PWY-7356;MetaCyc: PWY-6907	"Thiamine metabolism";"Vitamin B1 (thiamin) metabolism";"Thiamine diphosphate biosynthesis IV (eukaryotes)";"Thiamine salvage III";"Thiamine salvage IV (yeast)";"Thiamine diphosphate biosynthesis III (Staphylococcus)"
XP_053945349.1	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
XP_053965729.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053958360.1	9	Reactome: R-HSA-6798695;Reactome: R-HSA-380972;Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-5674135;Reactome: R-HSA-8943724	"Neutrophil degranulation";"Energy dependent regulation of mTOR by LKB1-AMPK";"Amino acids regulate mTORC1";"mTOR signalling";"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTORC1-mediated signalling";"MAP2K and MAPK activation";"Regulation of PTEN gene transcription"
XP_053959896.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053953753.1	3	MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783	"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
XP_053963855.1	14	MetaCyc: PWY-8053;KEGG: 00561+3.1.3.4;Reactome: R-HSA-1483213;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;MetaCyc: PWY-6453;KEGG: 00565+3.1.3.4;MetaCyc: PWY-8052;MetaCyc: PWY-8055;Reactome: R-HSA-4419969;MetaCyc: PWY-8051;KEGG: 00564+3.1.3.4;Reactome: R-HSA-75109;Reactome: R-HSA-1483191	"Anandamide biosynthesis II";"Glycerolipid metabolism";"Synthesis of PE";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Stigma estolide biosynthesis";"Ether lipid metabolism";"2-arachidonoylglycerol biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Depolymerisation of the Nuclear Lamina";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Triglyceride biosynthesis";"Synthesis of PC"
XP_053963402.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053967316.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053948342.1	1	MetaCyc: PWY-6938	"NADH repair"
XP_053964174.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_053956997.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053962504.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053962682.1	8	MetaCyc: PWY-2301;MetaCyc: PWY-6664;MetaCyc: PWY-6580;KEGG: 00521+5.5.1.4;KEGG: 00562+5.5.1.4;MetaCyc: PWY-4661;MetaCyc: PWY-6372;Reactome: R-HSA-1855183	"Myo-inositol biosynthesis";"Di-myo-inositol phosphate biosynthesis";"Phosphatidylinositol biosynthesis I (bacteria)";"Streptomycin biosynthesis";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of IP2, IP, and Ins in the cytosol"
XP_053950952.1	7	Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-2500257;Reactome: R-HSA-2468052;Reactome: R-HSA-9018519;Reactome: R-HSA-2470946;Reactome: R-HSA-1221632	"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"Resolution of Sister Chromatid Cohesion";"Establishment of Sister Chromatid Cohesion";"Estrogen-dependent gene expression";"Cohesin Loading onto Chromatin";"Meiotic synapsis"
XP_053962689.1	4	Reactome: R-HSA-983168;Reactome: R-HSA-6802952;Reactome: R-HSA-6798695;Reactome: R-HSA-1632852	"Antigen processing: Ubiquitination & Proteasome degradation";"Signaling by BRAF and RAF fusions";"Neutrophil degranulation";"Macroautophagy"
XP_053953628.1	2	Reactome: R-HSA-2243919;Reactome: R-HSA-1566948	"Crosslinking of collagen fibrils";"Elastic fibre formation"
XP_053961476.1	2	KEGG: 00970+6.1.1.7;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_053952363.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053957815.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053964718.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053966738.1	2	Reactome: R-HSA-5205685;Reactome: R-HSA-1268020	"Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import"
XP_053948706.1	4	MetaCyc: PWY-7286;Reactome: R-HSA-6782315;MetaCyc: PWY-6829;MetaCyc: PWY-7285	"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)";"Methylwyosine biosynthesis"
XP_053962557.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053965850.1	4	Reactome: R-HSA-5696394;Reactome: R-HSA-532668;Reactome: R-HSA-5696395;Reactome: R-HSA-3108214	"DNA Damage Recognition in GG-NER";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Formation of Incision Complex in GG-NER";"SUMOylation of DNA damage response and repair proteins"
XP_053952755.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053967834.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex"
XP_053965678.1	2	Reactome: R-HSA-5362517;Reactome: R-HSA-204174	"Signaling by Retinoic Acid";"Regulation of pyruvate dehydrogenase (PDH) complex"
XP_053957576.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053953365.1	11	Reactome: R-HSA-2644606;Reactome: R-HSA-205043;Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-193692;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700;Reactome: R-HSA-2122948;Reactome: R-HSA-9017802;Reactome: R-HSA-3928665	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NRIF signals cell death from the nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulated proteolysis of p75NTR";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Noncanonical activation of NOTCH3";"EPH-ephrin mediated repulsion of cells"
XP_053961732.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053950171.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_053948536.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053952377.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053965858.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053953713.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053963815.1	2	KEGG: 00970+6.1.1.15;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
XP_053964710.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053962260.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053949827.1	3	KEGG: 00220+3.5.1.14;Reactome: R-HSA-5579007;Reactome: R-HSA-5423646	"Arginine biosynthesis";"Defective ACY1 causes encephalopathy";"Aflatoxin activation and detoxification"
XP_053950252.1	7	Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-73780;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_053961543.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053965195.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_053961847.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053968944.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053969546.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053952715.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053949103.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-3214847	"Ub-specific processing proteases";"HATs acetylate histones"
XP_053949149.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
XP_053950030.1	12	Reactome: R-HSA-6807878;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295	"COPI-mediated anterograde transport";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Mitotic Prometaphase";"Aggrephagy";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation"
XP_053961122.1	6	Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68867	"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"Unwinding of DNA";"Assembly of the pre-replicative complex"
XP_053957443.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_053957855.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053964758.1	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053957402.1	13	Reactome: R-HSA-5099900;Reactome: R-HSA-416993;Reactome: R-HSA-3928665;Reactome: R-HSA-8866427;Reactome: R-HSA-8964038;Reactome: R-HSA-5140745;Reactome: R-HSA-2132295;Reactome: R-HSA-182218;Reactome: R-HSA-177504;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-167590;Reactome: R-HSA-437239	"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors";"EPH-ephrin mediated repulsion of cells";"VLDLR internalisation and degradation";"LDL clearance";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation";"Retrograde neurotrophin signalling";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Nef Mediated CD4 Down-regulation";"Recycling pathway of L1"
XP_053951065.1	9	Reactome: R-HSA-70263;MetaCyc: PWY-1042;MetaCyc: PWY-7003;MetaCyc: PWY-5484;Reactome: R-HSA-70171;KEGG: 00710+1.2.1.12;MetaCyc: PWY-8004;MetaCyc: PWY-6901;KEGG: 00010+1.2.1.12	"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Glycerol degradation to butanol";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Carbon fixation in photosynthetic organisms";"Entner-Doudoroff pathway I";"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis"
XP_053949768.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053954193.1	9	MetaCyc: PWY-241;Reactome: R-HSA-1475029;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1	"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism"
XP_053945699.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053957198.1	4	Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-5689880;Reactome: R-HSA-111465	"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"Ub-specific processing proteases";"Apoptotic cleavage of cellular proteins"
XP_053951056.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_053949934.1	4	Reactome: R-HSA-5358493;MetaCyc: PWY-7546;Reactome: R-HSA-8849175;MetaCyc: PWY-6482	"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)";"Threonine catabolism";"Diphthamide biosynthesis I (archaea)"
XP_053966128.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_053946362.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_053945692.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053957866.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_053952691.1	2	KEGG: 00280+1.3.8.4;Reactome: R-HSA-70895	"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism"
XP_053960916.1	13	Reactome: R-HSA-6802946;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-9649948;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6802948;Reactome: R-HSA-5674135;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6802955;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6802952;KEGG: 05163+2.7.11.1	"Signaling by moderate kinase activity BRAF mutants";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Signaling downstream of RAS mutants";"mTOR signaling pathway";"Signaling by high-kinase activity BRAF mutants";"MAP2K and MAPK activation";"Relaxin signaling pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Signaling by BRAF and RAF fusions";"Human cytomegalovirus infection"
XP_053962121.1	24	Reactome: R-HSA-190840;Reactome: R-HSA-983189;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-6807878;Reactome: R-HSA-8852276;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-9648025;Reactome: R-HSA-1445148;Reactome: R-HSA-2132295;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-190861;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-380320;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833	"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Kinesins";"RHO GTPases Activate Formins";"Recycling pathway of L1";"COPI-mediated anterograde transport";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"EML4 and NUDC in mitotic spindle formation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"MHC class II antigen presentation";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Gap junction assembly";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of NuMA to mitotic centrosomes";"Aggrephagy";"Cilium Assembly"
XP_053947935.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_053959123.1	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
XP_053969693.1	2	Reactome: R-HSA-6798695;MetaCyc: PWY-7511	"Neutrophil degranulation";"Protein ubiquitination"
XP_053946856.1	3	MetaCyc: PWY-8099;MetaCyc: PWY-7158;KEGG: 00790+4.2.1.96	"Tetrahydropteridine recycling";"L-phenylalanine degradation V";"Folate biosynthesis"
XP_053961230.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361;Reactome: R-HSA-5250958	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Neurexins and neuroligins";"Toxicity of botulinum toxin type B (BoNT/B)"
XP_053950758.1	3	Reactome: R-HSA-1369062;Reactome: R-HSA-8964058;Reactome: R-HSA-9029569	"ABC transporters in lipid homeostasis";"HDL remodeling";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_053957352.1	13	KEGG: 00770+3.6.1.9;KEGG: 00500+3.6.1.9;Reactome: R-HSA-74259;MetaCyc: PWY-7821;KEGG: 00230+3.6.1.9;MetaCyc: PWY-7206;MetaCyc: PWY-7187;MetaCyc: PWY-7184;KEGG: 00240+3.6.1.9;KEGG: 00760+3.6.1.9;KEGG: 00740+3.6.1.9;MetaCyc: PWY-6545;KEGG: 00230+3.6.1.66	"Pantothenate and CoA biosynthesis";"Starch and sucrose metabolism";"Purine catabolism";"Tunicamycin biosynthesis";"Purine metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Nicotinate and nicotinamide metabolism";"Riboflavin metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism"
XP_053966010.1	5	KEGG: 00052+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00603+3.2.1.22	"Galactose metabolism";"Sphingolipid metabolism";"Glycerolipid metabolism";"Stachyose degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series"
XP_053951483.1	5	Reactome: R-HSA-196025;Reactome: R-HSA-190873;Reactome: R-HSA-3928665;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Formation of annular gap junctions";"Gap junction degradation";"EPH-ephrin mediated repulsion of cells";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053964030.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053947598.1	2	Reactome: R-HSA-1268020;MetaCyc: PWY-7533	"Mitochondrial protein import";"Gliotoxin biosynthesis"
XP_053966425.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053961052.1	58	Reactome: R-HSA-382556;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-4608870;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-450408;Reactome: R-HSA-6798695;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-5689901;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-174184;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258	"ABC-family proteins mediated transport";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Asymmetric localization of PCP proteins";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neutrophil degranulation";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Metalloprotease DUBs";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL"
XP_053964588.1	13	MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7182;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-7709;MetaCyc: PWY-5123;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-7721;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-6859	"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"Linalool biosynthesis I";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Methyl phomopsenoate biosynthesis";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"All-trans-farnesol biosynthesis"
XP_053966939.1	5	MetaCyc: PWY-6558;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-3656253	"Heparan sulfate biosynthesis (late stages)";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS"
XP_053967869.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053954424.1	14	Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-1912408;Reactome: R-HSA-8943723;Reactome: R-HSA-9022692;Reactome: R-HSA-8934593;Reactome: R-HSA-5687128;Reactome: R-HSA-426486;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-203927;Reactome: R-HSA-8986944;Reactome: R-HSA-9018519	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"Pre-NOTCH Transcription and Translation";"Regulation of PTEN mRNA translation";"Regulation of MECP2 expression and activity";"Regulation of RUNX1 Expression and Activity";"MAPK6/MAPK4 signaling";"Small interfering RNA (siRNA) biogenesis";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"MicroRNA (miRNA) biogenesis";"Transcriptional Regulation by MECP2";"Estrogen-dependent gene expression"
XP_053956470.1	3	KEGG: 04070+3.1.3.78;MetaCyc: PWY-6367;MetaCyc: PWY-6368	"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"3-phosphoinositide degradation"
XP_053950710.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053961938.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053962501.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053966058.1	6	MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_053949931.1	3	Reactome: R-HSA-73621;Reactome: R-HSA-196807;Reactome: R-HSA-74259	"Pyrimidine catabolism";"Nicotinate metabolism";"Purine catabolism"
XP_053951479.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053958726.1	5	MetaCyc: PWY-5514;MetaCyc: PWY-6855;Reactome: R-HSA-70171;MetaCyc: PWY-6906;KEGG: 00520+3.5.99.6	"UDP-N-acetyl-D-galactosamine biosynthesis II";"Chitin degradation I (archaea)";"Glycolysis";"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism"
XP_053961637.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053966050.1	3	MetaCyc: PWY-6117;MetaCyc: PWY-0;KEGG: 00330+2.3.1.57	"Spermine and spermidine degradation I";"Putrescine degradation III";"Arginine and proline metabolism"
XP_053945479.1	3	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
XP_053969835.1	4	Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-8866654	"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_053968228.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053961930.1	7	Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-165159	"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"TP53 Regulates Metabolic Genes";"mTOR signalling"
XP_053953406.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053957312.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053962731.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1482798	"Mitochondrial protein import";"Acyl chain remodeling of CL"
XP_053962787.1	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_053962762.1	6	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-201722;Reactome: R-HSA-8866654;Reactome: R-HSA-112382;Reactome: R-HSA-5632684	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of the beta-catenin:TCF transactivating complex";"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of RNA Pol II elongation complex";"Hedgehog 'on' state"
XP_053958323.1	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
XP_053967572.1	5	Reactome: R-HSA-75896;Reactome: R-HSA-9033500;KEGG: 00565+2.5.1.26;MetaCyc: PWY-7782;Reactome: R-HSA-9033241	"Plasmalogen biosynthesis";"TYSND1 cleaves peroxisomal proteins";"Ether lipid metabolism";"Plasmalogen biosynthesis";"Peroxisomal protein import"
XP_053953831.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_053964038.1	3	Reactome: R-HSA-191859;Reactome: R-HSA-6804760;Reactome: R-HSA-3214858	"snRNP Assembly";"Regulation of TP53 Activity through Methylation";"RMTs methylate histone arginines"
XP_053959336.1	22	Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-2500257;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-5663220;Reactome: R-HSA-195253;Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-6811558;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025	"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Resolution of Sister Chromatid Cohesion";"Beta-catenin phosphorylation cascade";"RAF activation";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"RHO GTPases Activate Formins";"Degradation of beta-catenin by the destruction complex";"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation"
XP_053947176.1	9	MetaCyc: PWY-5789;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5743;MetaCyc: PWY-7115;MetaCyc: PWY-7117;Reactome: R-HSA-1475029;MetaCyc: PWY-5744;MetaCyc: PWY-241	"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Reversible hydration of carbon dioxide";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NADP-ME type"
XP_053962148.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053950750.1	2	KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7	"Aminobenzoate degradation";"Pyruvate metabolism"
XP_053961238.1	4	Reactome: R-HSA-6794361;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-5250958	"Neurexins and neuroligins";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)"
XP_053951845.1	9	Reactome: R-HSA-6802952;Reactome: R-HSA-6798695;Reactome: R-HSA-6802955;Reactome: R-HSA-445355;Reactome: R-HSA-114608;Reactome: R-HSA-6802946;Reactome: R-HSA-9649948;Reactome: R-HSA-6802948;Reactome: R-HSA-5674135	"Signaling by BRAF and RAF fusions";"Neutrophil degranulation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Smooth Muscle Contraction";"Platelet degranulation";"Signaling by moderate kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Signaling by high-kinase activity BRAF mutants";"MAP2K and MAPK activation"
XP_053961871.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_053946886.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053955975.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_053965941.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_053945094.1	5	KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;MetaCyc: PWY-5084	"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"Tryptophan metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA"
XP_053957389.1	1	Reactome: R-HSA-193648	"NRAGE signals death through JNK"
XP_053967270.1	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053951453.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053960991.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-1368108;MetaCyc: PWY-5381;Reactome: R-HSA-197264;KEGG: 00760+6.3.4.21	"Neutrophil degranulation";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Pyridine nucleotide cycling (plants)";"Nicotinamide salvaging";"Nicotinate and nicotinamide metabolism"
XP_053966295.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_053962375.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053962923.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053966530.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053952341.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053945845.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_053969302.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053949870.1	17	Reactome: R-HSA-5607764;Reactome: R-HSA-450321;Reactome: R-HSA-937042;Reactome: R-HSA-168638;Reactome: R-HSA-5357956;Reactome: R-HSA-1169091;Reactome: R-HSA-9645460;Reactome: R-HSA-445989;Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-9014325;Reactome: R-HSA-450302;Reactome: R-HSA-9020702;Reactome: R-HSA-4086398;Reactome: R-HSA-937072;Reactome: R-HSA-975163;Reactome: R-HSA-5689880	"CLEC7A (Dectin-1) signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex";"NOD1/2 Signaling Pathway";"TNFR1-induced NFkappaB signaling pathway";"Activation of NF-kappaB in B cells";"Alpha-protein kinase 1 signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Downstream TCR signaling";"FCERI mediated NF-kB activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"activated TAK1 mediates p38 MAPK activation";"Interleukin-1 signaling";"Ca2+ pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"Ub-specific processing proteases"
XP_053969892.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053967394.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_053964973.1	10	Reactome: R-HSA-9615017;Reactome: R-HSA-9022702;Reactome: R-HSA-400206;Reactome: R-HSA-8936459;Reactome: R-HSA-3899300;Reactome: R-HSA-9022692;Reactome: R-HSA-427413;Reactome: R-HSA-983231;Reactome: R-HSA-9022538;Reactome: R-HSA-9022699	"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates transcription of neuronal ligands";"Regulation of lipid metabolism by PPARalpha";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of transcription cofactors";"Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates neuronal receptors and channels"
XP_053961346.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053950822.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053969899.1	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
XP_053965164.1	11	Reactome: R-HSA-3000170;Reactome: R-HSA-202733;Reactome: R-HSA-975634;Reactome: R-HSA-3560801;Reactome: R-HSA-2024096;Reactome: R-HSA-3656237;Reactome: R-HSA-3560783;Reactome: R-HSA-2022928;Reactome: R-HSA-1971475;Reactome: R-HSA-4420332;Reactome: R-HSA-3656253	"Syndecan interactions";"Cell surface interactions at the vascular wall";"Retinoid metabolism and transport";"Defective B3GAT3 causes JDSSDHD";"HS-GAG degradation";"Defective EXT2 causes exostoses 2";"Defective B4GALT7 causes EDS, progeroid type";"HS-GAG biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS"
XP_053963925.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053963432.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053967857.1	4	Reactome: R-HSA-2122947;Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-201722	"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex"
XP_053961089.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053962534.1	16	Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053963439.1	2	Reactome: R-HSA-8950505;Reactome: R-HSA-1237112	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Methionine salvage pathway"
XP_053967553.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_053948479.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053956906.1	25	Reactome: R-HSA-8939247;Reactome: R-HSA-8939902;Reactome: R-HSA-8941326;Reactome: R-HSA-8939246;Reactome: R-HSA-8936459;Reactome: R-HSA-8939243;Reactome: R-HSA-8939242;Reactome: R-HSA-8878166;Reactome: R-HSA-8941284;Reactome: R-HSA-8951911;Reactome: R-HSA-8949275;Reactome: R-HSA-8941332;Reactome: R-HSA-8939245;Reactome: R-HSA-8934593;Reactome: R-HSA-8951936;Reactome: R-HSA-8940973;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-8935964;Reactome: R-HSA-9018519;Reactome: R-HSA-8939256;Reactome: R-HSA-8877330;Reactome: R-HSA-8941858;Reactome: R-HSA-8941333;Reactome: R-HSA-8931987	"RUNX1 regulates transcription of genes involved in interleukin signaling";"Regulation of RUNX2 expression and activity";"RUNX2 regulates bone development";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"Transcriptional regulation by RUNX2";"RUNX2 regulates chondrocyte maturation";"RUNX3 regulates RUNX1-mediated transcription";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX2 regulates genes involved in cell migration";"RUNX1 regulates transcription of genes involved in BCR signaling";"Regulation of RUNX1 Expression and Activity";"RUNX3 regulates p14-ARF";"RUNX2 regulates osteoblast differentiation";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 regulates expression of components of tight junctions";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in WNT signaling";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"Regulation of RUNX3 expression and activity";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates estrogen receptor mediated transcription"
XP_053946891.1	12	Reactome: R-HSA-2894862;Reactome: R-HSA-193692;Reactome: R-HSA-2691232;Reactome: R-HSA-1442490;Reactome: R-HSA-2644606;Reactome: R-HSA-177929;Reactome: R-HSA-5362798;Reactome: R-HSA-2660826;Reactome: R-HSA-75893;Reactome: R-HSA-1251985;Reactome: R-HSA-2122948;Reactome: R-HSA-982772	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulated proteolysis of p75NTR";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Collagen degradation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Signaling by EGFR";"Release of Hh-Np from the secreting cell";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"TNF signaling";"Nuclear signaling by ERBB4";"Activated NOTCH1 Transmits Signal to the Nucleus";"Growth hormone receptor signaling"
XP_053967677.1	3	MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2;Reactome: R-HSA-1650814	"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism";"Collagen biosynthesis and modifying enzymes"
XP_053957925.1	11	Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-418597;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-164378;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-163615;Reactome: R-HSA-170670	"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events";"Hedgehog 'off' state";"G alpha (i) signalling events";"PKA activation in glucagon signalling";"Purine metabolism";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation";"Adenylate cyclase inhibitory pathway"
XP_053953857.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053960986.1	5	Reactome: R-HSA-197264;Reactome: R-HSA-1368108;MetaCyc: PWY-5381;KEGG: 00760+6.3.4.21;Reactome: R-HSA-6798695	"Nicotinamide salvaging";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"Neutrophil degranulation"
XP_053954378.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053949957.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053950780.1	8	Reactome: R-HSA-9620244;KEGG: 00230+2.7.4.8;Reactome: R-HSA-9609736;Reactome: R-HSA-9617324;Reactome: R-HSA-442982;Reactome: R-HSA-5673001;Reactome: R-HSA-438066;MetaCyc: PWY-7221	"Long-term potentiation";"Purine metabolism";"Assembly and cell surface presentation of NMDA receptors";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Ras activation upon Ca2+ influx through NMDA receptor";"RAF/MAP kinase cascade";"Unblocking of NMDA receptors, glutamate binding and activation";"Guanosine ribonucleotides de novo biosynthesis"
XP_053963382.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053949217.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053952566.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053961073.1	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
XP_053953804.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053966538.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053963225.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053963046.1	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
XP_053968102.1	6	Reactome: R-HSA-1369062;Reactome: R-HSA-2046106;Reactome: R-HSA-390247;Reactome: R-HSA-2046105;Reactome: R-HSA-9603798;Reactome: R-HSA-5684045	"ABC transporters in lipid homeostasis";"alpha-linolenic acid (ALA) metabolism";"Beta-oxidation of very long chain fatty acids";"Linoleic acid (LA) metabolism";"Class I peroxisomal membrane protein import";"Defective ABCD1 causes adrenoleukodystrophy (ALD)"
XP_053964982.1	10	Reactome: R-HSA-427413;Reactome: R-HSA-983231;Reactome: R-HSA-9022538;Reactome: R-HSA-9022699;Reactome: R-HSA-9615017;Reactome: R-HSA-9022702;Reactome: R-HSA-400206;Reactome: R-HSA-8936459;Reactome: R-HSA-3899300;Reactome: R-HSA-9022692	"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates neuronal receptors and channels";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates transcription of neuronal ligands";"Regulation of lipid metabolism by PPARalpha";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of transcription cofactors";"Regulation of MECP2 expression and activity"
XP_053970218.1	3	Reactome: R-HSA-1650814;KEGG: 00330+1.14.11.2;MetaCyc: PWY-7894	"Collagen biosynthesis and modifying enzymes";"Arginine and proline metabolism";"Procollagen hydroxylation and glycosylation"
XP_053966556.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053958077.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053963134.1	10	MetaCyc: PWY-6372;Reactome: R-HSA-1855167;Reactome: R-HSA-1855191;MetaCyc: PWY-4661;KEGG: 04070+2.7.1.158;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6554;MetaCyc: PWY-6362;MetaCyc: PWY-6361;MetaCyc: PWY-6369	"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of pyrophosphates in the cytosol";"Synthesis of IPs in the nucleus";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Inositol diphosphates biosynthesis"
XP_053960743.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053955044.1	5	Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-9615710;Reactome: R-HSA-162588;Reactome: R-HSA-917729	"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Late endosomal microautophagy";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)"
XP_053946152.1	6	Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-5663220	"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"RHO GTPases Activate Formins"
XP_053953300.1	11	Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-212436;Reactome: R-HSA-400253;Reactome: R-HSA-1368108;Reactome: R-HSA-9018519;Reactome: R-HSA-400206;Reactome: R-HSA-1989781;Reactome: R-HSA-383280;Reactome: R-HSA-381340;Reactome: R-HSA-2426168	"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"Generic Transcription Pathway";"Circadian Clock";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Estrogen-dependent gene expression";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression";"Nuclear Receptor transcription pathway";"Transcriptional regulation of white adipocyte differentiation";"Activation of gene expression by SREBF (SREBP)"
XP_053949990.1	5	Reactome: R-HSA-6804757;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-1257604;Reactome: R-HSA-5674400	"Regulation of TP53 Degradation";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling";"Constitutive Signaling by AKT1 E17K in Cancer"
XP_053950453.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_053967308.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053955895.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_053965469.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_053969024.1	5	Reactome: R-HSA-3108214;Reactome: R-HSA-110329;Reactome: R-HSA-5221030;Reactome: R-HSA-110328;Reactome: R-HSA-110357	"SUMOylation of DNA damage response and repair proteins";"Cleavage of the damaged pyrimidine";"TET1,2,3 and TDG demethylate DNA";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Displacement of DNA glycosylase by APEX1"
XP_053966565.1	2	Reactome: R-HSA-8953750;Reactome: R-HSA-8939243	"Transcriptional Regulation by E2F6";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053965462.1	5	Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7269;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23	"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_053951147.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_053961286.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053949705.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_053954654.1	2	Reactome: R-HSA-1483152;Reactome: R-HSA-1483115	"Hydrolysis of LPE";"Hydrolysis of LPC"
XP_053968417.1	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
XP_053970061.1	7	MetaCyc: PWY-5469;MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-7445;MetaCyc: PWY-6824	"Sesamin biosynthesis";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Betanidin degradation";"Phenylpropanoid biosynthesis";"Luteolin triglucuronide degradation";"Justicidin B biosynthesis"
XP_053967155.1	10	MetaCyc: PWY-6174;MetaCyc: PWY-7391;MetaCyc: PWY-7524;KEGG: 00900+2.3.3.10;KEGG: 00280+2.3.3.10;KEGG: 00650+2.3.3.10;KEGG: 00072+2.3.3.10;Reactome: R-HSA-1989781;MetaCyc: PWY-7571;MetaCyc: PWY-922	"Mevalonate pathway II (archaea)";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway III (archaea)";"Terpenoid backbone biosynthesis";"Valine, leucine and isoleucine degradation";"Butanoate metabolism";"Synthesis and degradation of ketone bodies";"PPARA activates gene expression";"Ferrichrome A biosynthesis";"Mevalonate pathway I"
XP_053964706.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053952638.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053967898.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053962905.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_053958861.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053960082.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053956828.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053951008.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-8949215	"Factors involved in megakaryocyte development and platelet production";"Mitochondrial calcium ion transport"
XP_053964597.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_053969979.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053957242.1	1	Reactome: R-HSA-71288	"Creatine metabolism"
XP_053953155.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053959438.1	3	Reactome: R-HSA-3299685;Reactome: R-HSA-5628897;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"TP53 Regulates Metabolic Genes";"Glutathione metabolism"
XP_053966516.1	6	Reactome: R-HSA-399997;Reactome: R-HSA-456926;Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-434316;Reactome: R-HSA-416476	"Acetylcholine regulates insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G alpha (q) signalling events"
XP_053964536.1	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
XP_053946119.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053968311.1	2	Reactome: R-HSA-196819;KEGG: 00230+4.6.1.1	"Vitamin B1 (thiamin) metabolism";"Purine metabolism"
XP_053955633.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053951000.1	29	Reactome: R-HSA-6803204;Reactome: R-HSA-912446;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693579;Reactome: R-HSA-6803207;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693554;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5685942;Reactome: R-HSA-3371453;Reactome: R-HSA-5693571;Reactome: R-HSA-349425;Reactome: R-HSA-5693565;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6804760;Reactome: R-HSA-2559586;Reactome: R-HSA-69473;Reactome: R-HSA-69541;Reactome: R-HSA-5693616;Reactome: R-HSA-5693548;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6804757;Reactome: R-HSA-5693568;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6796648	"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Meiotic recombination";"Relaxin signaling pathway";"Homologous DNA Pairing and Strand Exchange";"TP53 Regulates Transcription of Caspase Activators and Caspases";"mTOR signaling pathway";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Human papillomavirus infection";"HDR through Homologous Recombination (HRR)";"Regulation of HSF1-mediated heat shock response";"Nonhomologous End-Joining (NHEJ)";"Autodegradation of the E3 ubiquitin ligase COP1";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Human cytomegalovirus infection";"Regulation of TP53 Activity through Methylation";"DNA Damage/Telomere Stress Induced Senescence";"G2/M DNA damage checkpoint";"Stabilization of p53";"Presynaptic phase of homologous DNA pairing and strand exchange";"Sensing of DNA Double Strand Breaks";"PI3K-Akt signaling pathway";"Regulation of TP53 Degradation";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Thermogenesis";"Human immunodeficiency virus 1 infection";"TP53 Regulates Transcription of DNA Repair Genes"
XP_053956820.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053961986.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053958063.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053963724.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_053960651.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053967300.1	5	Reactome: R-HSA-204005;Reactome: R-HSA-1655829;Reactome: R-HSA-5694530;Reactome: R-HSA-2132295;Reactome: R-HSA-983170	"COPII-mediated vesicle transport";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER";"MHC class II antigen presentation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"
XP_053949998.1	5	Reactome: R-HSA-5218920;Reactome: R-HSA-1257604;Reactome: R-HSA-389357;Reactome: R-HSA-6804757;Reactome: R-HSA-5674400	"VEGFR2 mediated vascular permeability";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling";"Regulation of TP53 Degradation";"Constitutive Signaling by AKT1 E17K in Cancer"
XP_053966615.1	3	MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II"
XP_053952153.1	5	KEGG: 00510+2.4.1.68;KEGG: 00513+2.4.1.68;KEGG: 00533+2.4.1.68;Reactome: R-HSA-975578;MetaCyc: PWY-7426	"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Glycosaminoglycan biosynthesis - keratan sulfate";"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)"
XP_053958747.1	1	Reactome: R-HSA-5689603	"UCH proteinases"
XP_053969272.1	4	Reactome: R-HSA-964975;MetaCyc: PWY-7204;MetaCyc: PWY-7282;KEGG: 00750+1.4.3.5	"Vitamins B6 activation to pyridoxal phosphate";"Pyridoxal 5'-phosphate salvage II (plants)";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Vitamin B6 metabolism"
XP_053957949.1	3	Reactome: R-HSA-2206302;Reactome: R-HSA-2024101;Reactome: R-HSA-2024096	"MPS I - Hurler syndrome";"CS/DS degradation";"HS-GAG degradation"
XP_053965381.1	3	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-390471	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis"
XP_053959380.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053966442.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053959358.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053958774.1	3	Reactome: R-HSA-8876725;KEGG: 00310+2.1.1.60;Reactome: R-HSA-2514859	"Protein methylation";"Lysine degradation";"Inactivation, recovery and regulation of the phototransduction cascade"
XP_053961256.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053949055.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053956752.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053965457.1	5	KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7269;MetaCyc: PWY-7268	"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
XP_053969570.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053965545.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053947011.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053964699.1	3	Reactome: R-HSA-418597;Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13	"G alpha (z) signalling events";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_053960230.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_053951758.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053947689.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053964692.1	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
XP_053948780.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053946182.1	3	Reactome: R-HSA-110328;Reactome: R-HSA-110357;Reactome: R-HSA-110329	"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Displacement of DNA glycosylase by APEX1";"Cleavage of the damaged pyrimidine"
XP_053965311.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053954847.1	1	Reactome: R-HSA-427652	"Sodium-coupled phosphate cotransporters"
XP_053965404.1	33	Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-3301854;Reactome: R-HSA-5663220;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-141444;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453	"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Separation of Sister Chromatids";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"Nuclear Pore Complex (NPC) Disassembly";"RHO GTPases Activate Formins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Late Events";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response"
XP_053954509.1	6	Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-176187;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607	"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends"
XP_053952179.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053965646.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053945710.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053957548.1	16	Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053955063.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_053957027.1	3	Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"MHC class II antigen presentation";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053952251.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053967185.1	7	MetaCyc: PWY-5921;Reactome: R-HSA-210500;Reactome: R-HSA-5628897;KEGG: 00471+3.5.1.2;Reactome: R-HSA-8964539;KEGG: 00250+3.5.1.2;KEGG: 00220+3.5.1.2	"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate Neurotransmitter Release Cycle";"TP53 Regulates Metabolic Genes";"D-Glutamine and D-glutamate metabolism";"Glutamate and glutamine metabolism";"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis"
XP_053963521.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_053959626.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053960938.1	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
XP_053950126.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053954684.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053945718.1	14	Reactome: R-HSA-75876;MetaCyc: PWY-7619;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-5080	"Synthesis of very long-chain fatty acyl-CoAs";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I"
XP_053946173.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053950472.1	33	Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-159230;Reactome: R-HSA-159236;Reactome: R-HSA-9648025;Reactome: R-HSA-180910;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-5663220;Reactome: R-HSA-3301854;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-168333;Reactome: R-HSA-141444	"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Transport of the SLBP Dependant Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"EML4 and NUDC in mitotic spindle formation";"Vpr-mediated nuclear import of PICs";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"RHO GTPases Activate Formins";"Nuclear Pore Complex (NPC) Disassembly";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_053965417.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053963548.1	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
XP_053959318.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053964016.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_053961956.1	9	Reactome: R-HSA-2173788;Reactome: R-HSA-3642279;Reactome: R-HSA-2173791;Reactome: R-HSA-2173789;Reactome: R-HSA-3656535;Reactome: R-HSA-3645790;Reactome: R-HSA-3656532;Reactome: R-HSA-3304356;Reactome: R-HSA-5689603	"Downregulation of TGF-beta receptor signaling";"TGFBR2 MSI Frameshift Mutants in Cancer";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGF-beta receptor signaling activates SMADs";"TGFBR1 LBD Mutants in Cancer";"TGFBR2 Kinase Domain Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"UCH proteinases"
XP_053953185.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_053957521.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053960930.1	7	Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-5663220	"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins"
XP_053963027.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053966591.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053955832.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053950736.1	1	KEGG: 00970+6.1.1.21	"Aminoacyl-tRNA biosynthesis"
XP_053945750.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053955839.1	4	MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902	"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)"
XP_053965351.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053959350.1	22	Reactome: R-HSA-6811558;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-432142;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-5673000;Reactome: R-HSA-196299;Reactome: R-HSA-2500257;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-5358747	"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RAF activation";"Beta-catenin phosphorylation cascade";"Resolution of Sister Chromatid Cohesion";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S33 mutants of beta-catenin aren't phosphorylated"
XP_053947517.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053951174.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053952951.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_053948788.1	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_053955180.1	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053960238.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_053952183.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053968793.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_053952211.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053958895.1	4	KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32;MetaCyc: PWY-6803;MetaCyc: PWY-8051	"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I"
XP_053958392.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053954238.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053945959.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053962935.1	5	Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568	"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_053962422.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_053967480.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053958399.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053951038.1	11	Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-174437;Reactome: R-HSA-5685942;Reactome: R-HSA-69166;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-5693568	"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Removal of the Flap Intermediate from the C-strand";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_053956032.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053951219.1	3	Reactome: R-HSA-6785470;Reactome: R-HSA-8868766;Reactome: R-HSA-6787450	"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA modification in the mitochondrion"
XP_053946640.1	27	Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-159230;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-3301854;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214	"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP Dependant Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear Pore Complex (NPC) Disassembly";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins"
XP_053960476.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053956039.1	16	Reactome: R-HSA-8847993;Reactome: R-HSA-1250342;Reactome: R-HSA-1963640;Reactome: R-HSA-1963642;Reactome: R-HSA-1250196;Reactome: R-HSA-1227986;Reactome: R-HSA-1257604;Reactome: R-HSA-1251985;Reactome: R-HSA-1236394;Reactome: R-HSA-6785631;Reactome: R-HSA-1250347;Reactome: R-HSA-9664565;Reactome: R-HSA-2219530;Reactome: R-HSA-5673001;Reactome: R-HSA-8863795;Reactome: R-HSA-6811558	"ERBB2 Activates PTK6 Signaling";"PI3K events in ERBB4 signaling";"GRB2 events in ERBB2 signaling";"PI3K events in ERBB2 signaling";"SHC1 events in ERBB2 signaling";"Signaling by ERBB2";"PIP3 activates AKT signaling";"Nuclear signaling by ERBB4";"Signaling by ERBB4";"ERBB2 Regulates Cell Motility";"SHC1 events in ERBB4 signaling";"Signaling by ERBB2 KD Mutants";"Constitutive Signaling by Aberrant PI3K in Cancer";"RAF/MAP kinase cascade";"Downregulation of ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
XP_053951212.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053952207.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_053948325.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053958466.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053954930.1	5	Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-430039;Reactome: R-HSA-450604	"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 5' to 3' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA"
XP_053968745.1	1	Reactome: R-HSA-74217	"Purine salvage"
XP_053958809.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053958771.1	2	KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20	"Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis"
XP_053947014.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_053948289.1	2	Reactome: R-HSA-975957;Reactome: R-HSA-975956	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_053947501.1	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway"
XP_053957117.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053960732.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053958455.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_053962235.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053964126.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053956918.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053956863.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053955485.1	3	Reactome: R-HSA-418594;Reactome: R-HSA-375276;Reactome: R-HSA-416476	"G alpha (i) signalling events";"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_053966765.1	6	Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-399997;Reactome: R-HSA-456926	"G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Acetylcholine regulates insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)"
XP_053951171.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053952214.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053958020.1	3	Reactome: R-HSA-1660662;KEGG: 00600+3.2.1.45;KEGG: 00511+3.2.1.45	"Glycosphingolipid metabolism";"Sphingolipid metabolism";"Other glycan degradation"
XP_053965897.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_053966756.1	6	Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-456926;Reactome: R-HSA-399997	"G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Thrombin signalling through proteinase activated receptors (PARs)";"Acetylcholine regulates insulin secretion"
XP_053951588.1	2	Reactome: R-HSA-70921;KEGG: 00340+2.1.1.22	"Histidine catabolism";"Histidine metabolism"
XP_053951919.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053967330.1	9	MetaCyc: PWY-5663;MetaCyc: PWY-6983;Reactome: R-HSA-1474151;MetaCyc: PWY-7442;MetaCyc: PWY-6703;KEGG: 00790+3.5.4.16;MetaCyc: PWY-6147;MetaCyc: PWY-5664;MetaCyc: PWY-7852	"Erythro-tetrahydrobiopterin biosynthesis I";"Threo-tetrahydrobiopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Drosopterin and aurodrosopterin biosynthesis";"Preq0 biosynthesis";"Folate biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Erythro-tetrahydrobiopterin biosynthesis II";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)"
XP_053945171.1	6	MetaCyc: PWY-5484;KEGG: 00010+5.4.2.11;MetaCyc: PWY-1622;KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;KEGG: 00680+5.4.2.11	"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation I (serine pathway)";"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Methane metabolism"
XP_053947007.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-6783310	"Protein ubiquitination";"Fanconi Anemia Pathway"
XP_053960847.1	5	Reactome: R-HSA-8876198;Reactome: R-HSA-6798695;Reactome: R-HSA-1445148;Reactome: R-HSA-8873719;Reactome: R-HSA-1660499	"RAB GEFs exchange GTP for GDP on RABs";"Neutrophil degranulation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RAB geranylgeranylation";"Synthesis of PIPs at the plasma membrane"
XP_053954052.1	4	Reactome: R-HSA-2206292;Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2160916	"MPS VII - Sly syndrome";"HS-GAG degradation";"Neutrophil degranulation";"Hyaluronan uptake and degradation"
XP_053958041.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_053951030.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
XP_053969622.1	2	Reactome: R-HSA-6782315;Reactome: R-HSA-6787450	"tRNA modification in the nucleus and cytosol";"tRNA modification in the mitochondrion"
XP_053956950.1	8	MetaCyc: PWY-6901;KEGG: 00010+1.1.1.27;KEGG: 00640+1.1.1.27;MetaCyc: PWY-5481;Reactome: R-HSA-70268;KEGG: 00270+1.1.1.27;MetaCyc: PWY-8086;KEGG: 00620+1.1.1.27	"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis";"Propanoate metabolism";"Pyruvate fermentation to (S)-lactate";"Pyruvate metabolism";"Cysteine and methionine metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism"
XP_053960129.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053947493.1	10	KEGG: 05170+2.7.1.153;KEGG: 04150+2.7.1.153;Reactome: R-HSA-9027276;KEGG: 04070+2.7.1.153;KEGG: 00562+2.7.1.153;Reactome: R-HSA-1660499;KEGG: 04151+2.7.1.153;KEGG: 05165+2.7.1.153;MetaCyc: PWY-6352;KEGG: 05163+2.7.1.153	"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of PIPs at the plasma membrane";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"3-phosphoinositide biosynthesis";"Human cytomegalovirus infection"
XP_053947769.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_053956210.1	3	KEGG: 00511+3.2.1.51;Reactome: R-HSA-6798695;MetaCyc: PWY-6807	"Other glycan degradation";"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)"
XP_053966594.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053959199.1	22	MetaCyc: PWY-7726;MetaCyc: PWY-7049;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7592;MetaCyc: PWY-6958;MetaCyc: PWY-7601;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7728;MetaCyc: PWY-7035;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7053;MetaCyc: PWY-7725;MetaCyc: PWY-5353;MetaCyc: PWY-8041;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-7727;MetaCyc: PWY-6598;MetaCyc: PWY-7606;Reactome: R-HSA-75876	"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Sciadonate biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs"
XP_053952907.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053965307.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053958415.1	1	Reactome: R-HSA-1614635	"Sulfur amino acid metabolism"
XP_053949505.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053948967.1	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
XP_053955649.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_053955603.1	11	Reactome: R-HSA-983231;Reactome: R-HSA-8940973;Reactome: R-HSA-5663213;Reactome: R-HSA-8939236;KEGG: 04660+2.7.10.2;Reactome: R-HSA-5693565;Reactome: R-HSA-5685938;Reactome: R-HSA-69231;Reactome: R-HSA-428890;Reactome: R-HSA-525793;Reactome: R-HSA-2029482	"Factors involved in megakaryocyte development and platelet production";"RUNX2 regulates osteoblast differentiation";"RHO GTPases Activate WASPs and WAVEs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"T cell receptor signaling pathway";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDR through Single Strand Annealing (SSA)";"Cyclin D associated events in G1";"Role of ABL in ROBO-SLIT signaling";"Myogenesis";"Regulation of actin dynamics for phagocytic cup formation"
XP_053957721.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053945660.1	4	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"DARPP-32 events";"Th1 and Th2 cell differentiation"
XP_053953025.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053966791.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053960908.1	13	KEGG: 05163+2.7.11.1;Reactome: R-HSA-6802952;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6802955;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6802946;Reactome: R-HSA-6802948;Reactome: R-HSA-5674135;KEGG: 04150+2.7.11.1;Reactome: R-HSA-9649948	"Human cytomegalovirus infection";"Signaling by BRAF and RAF fusions";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Signaling by moderate kinase activity BRAF mutants";"Signaling by high-kinase activity BRAF mutants";"MAP2K and MAPK activation";"mTOR signaling pathway";"Signaling downstream of RAS mutants"
XP_053963187.1	6	MetaCyc: PWY-622;KEGG: 00500+2.4.1.18;Reactome: R-HSA-189085;MetaCyc: PWY-7900;MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1	"Starch biosynthesis";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism"
XP_053951989.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_053965434.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053957078.1	9	Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-167161;Reactome: R-HSA-76042	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance"
XP_053958603.1	2	Reactome: R-HSA-6803157;Reactome: R-HSA-6798695	"Antimicrobial peptides";"Neutrophil degranulation"
XP_053963748.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053954532.1	9	Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942	"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)"
XP_053958649.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_053950635.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053959135.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053945967.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_053970064.1	7	MetaCyc: PWY-6824;MetaCyc: PWY-7214;MetaCyc: PWY-5466;MetaCyc: PWY-5469;MetaCyc: PWY-7445;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7	"Justicidin B biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Matairesinol biosynthesis";"Sesamin biosynthesis";"Luteolin triglucuronide degradation";"Betanidin degradation";"Phenylpropanoid biosynthesis"
XP_053954539.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053969021.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053948588.1	9	MetaCyc: PWY-7533;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7112;KEGG: 00980+2.5.1.18;MetaCyc: PWY-4061;MetaCyc: PWY-6842;Reactome: R-HSA-156590;KEGG: 00480+2.5.1.18;KEGG: 00983+2.5.1.18	"Gliotoxin biosynthesis";"Drug metabolism - cytochrome P450";"4-hydroxy-2-nonenal detoxification";"Metabolism of xenobiotics by cytochrome P450";"Glutathione-mediated detoxification I";"Glutathione-mediated detoxification II";"Glutathione conjugation";"Glutathione metabolism";"Drug metabolism - other enzymes"
XP_053948252.1	24	Reactome: R-HSA-392851;Reactome: R-HSA-9009391;Reactome: R-HSA-6814122;Reactome: R-HSA-416482;Reactome: R-HSA-418592;Reactome: R-HSA-381676;Reactome: R-HSA-392170;Reactome: R-HSA-8964315;Reactome: R-HSA-8964616;Reactome: R-HSA-456926;Reactome: R-HSA-418594;Reactome: R-HSA-500657;Reactome: R-HSA-420092;Reactome: R-HSA-428930;Reactome: R-HSA-432040;Reactome: R-HSA-400042;Reactome: R-HSA-163359;Reactome: R-HSA-392451;Reactome: R-HSA-418217;Reactome: R-HSA-4086398;Reactome: R-HSA-202040;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-416476	"Prostacyclin signalling through prostacyclin receptor";"Extra-nuclear estrogen signaling";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (12/13) signalling events";"ADP signalling through P2Y purinoceptor 1";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through BTK";"G beta:gamma signalling through CDC42";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (i) signalling events";"Presynaptic function of Kainate receptors";"Glucagon-type ligand receptors";"Thromboxane signalling through TP receptor";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adrenaline,noradrenaline inhibits insulin secretion";"Glucagon signaling in metabolic regulation";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through PLC beta";"Ca2+ pathway";"G-protein activation";"G alpha (s) signalling events";"G alpha (z) signalling events";"G alpha (q) signalling events"
XP_053951550.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_053958485.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053948259.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053946274.1	5	KEGG: 00520+2.6.1.16;KEGG: 00250+2.6.1.16;MetaCyc: PWY-8013;Reactome: R-HSA-446210;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"Alanine, aspartate and glutamate metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Synthesis of UDP-N-acetyl-glucosamine";"CMP-legionaminate biosynthesis I"
XP_053952023.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053955041.1	7	Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-8943724;Reactome: R-HSA-166208;Reactome: R-HSA-9639288;Reactome: R-HSA-380972	"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTOR signalling";"Regulation of PTEN gene transcription";"mTORC1-mediated signalling";"Amino acids regulate mTORC1";"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_053947534.1	15	Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-2467813;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-174154;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174184;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-176407;Reactome: R-HSA-179409	"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Separation of Sister Chromatids";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC-Cdc20 mediated degradation of Nek2A"
XP_053962299.1	3	Reactome: R-HSA-5689880;Reactome: R-HSA-110314;Reactome: R-HSA-6783310	"Ub-specific processing proteases";"Recognition of DNA damage by PCNA-containing replication complex";"Fanconi Anemia Pathway"
XP_053969527.1	12	MetaCyc: PWY-6936;MetaCyc: PWY-2821;MetaCyc: PWY-1187;MetaCyc: PWY-6842;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6309;KEGG: 00380+2.6.1.7;MetaCyc: PWY-7901;Reactome: R-HSA-71240;MetaCyc: PWY-601;MetaCyc: PWY-801;KEGG: 00450+4.4.1.13	"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from phenylalanine";"Glucosinolate biosynthesis from homomethionine";"Glutathione-mediated detoxification II";"Cysteine and methionine metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Tryptophan metabolism";"Glucosinolate biosynthesis from tyrosine";"Tryptophan catabolism";"Glucosinolate biosynthesis from tryptophan";"Homocysteine and cysteine interconversion";"Selenocompound metabolism"
XP_053955466.1	12	Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-75955	"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation"
XP_053966786.1	83	Reactome: R-HSA-5654727;Reactome: R-HSA-8856828;Reactome: R-HSA-1433557;Reactome: R-HSA-5655291;Reactome: R-HSA-5654726;Reactome: R-HSA-1963640;Reactome: R-HSA-1963642;Reactome: R-HSA-8853334;Reactome: R-HSA-912526;Reactome: R-HSA-2871809;Reactome: R-HSA-5654704;Reactome: R-HSA-9026519;Reactome: R-HSA-2029482;Reactome: R-HSA-9607240;Reactome: R-HSA-5654720;Reactome: R-HSA-9634285;Reactome: R-HSA-1295596;Reactome: R-HSA-179812;Reactome: R-HSA-2730905;Reactome: R-HSA-5654719;Reactome: R-HSA-167044;Reactome: R-HSA-5654699;Reactome: R-HSA-5637810;Reactome: R-HSA-6807004;Reactome: R-HSA-9028335;Reactome: R-HSA-1250196;Reactome: R-HSA-9034864;Reactome: R-HSA-182971;Reactome: R-HSA-1236382;Reactome: R-HSA-388841;Reactome: R-HSA-1257604;Reactome: R-HSA-5654695;Reactome: R-HSA-354194;Reactome: R-HSA-8875360;Reactome: R-HSA-5654688;Reactome: R-HSA-9664565;Reactome: R-HSA-1250347;Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-180292;Reactome: R-HSA-8851805;Reactome: R-HSA-180336;Reactome: R-HSA-5654706;Reactome: R-HSA-8853338;Reactome: R-HSA-210993;Reactome: R-HSA-5654712;Reactome: R-HSA-8865999;Reactome: R-HSA-9645135;Reactome: R-HSA-5654710;Reactome: R-HSA-1433559;Reactome: R-HSA-391160;Reactome: R-HSA-5663213;Reactome: R-HSA-74751;Reactome: R-HSA-389359;Reactome: R-HSA-912631;Reactome: R-HSA-2424491;Reactome: R-HSA-8983432;Reactome: R-HSA-112412;Reactome: R-HSA-6811558;Reactome: R-HSA-5654693;Reactome: R-HSA-5654700;Reactome: R-HSA-983695;Reactome: R-HSA-8875555;Reactome: R-HSA-2428933;Reactome: R-HSA-9027284;Reactome: R-HSA-8856825;Reactome: R-HSA-5654732;Reactome: R-HSA-74749;Reactome: R-HSA-9028731;Reactome: R-HSA-5655253;Reactome: R-HSA-8851907;Reactome: R-HSA-8853659;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-2871796;Reactome: R-HSA-186763;Reactome: R-HSA-1839117;Reactome: R-HSA-5654733;Reactome: R-HSA-5654689;Reactome: R-HSA-2219530;Reactome: R-HSA-512988;Reactome: R-HSA-5655302;Reactome: R-HSA-8875656	"Negative regulation of FGFR2 signaling";"Clathrin-mediated endocytosis";"Signaling by SCF-KIT";"Signaling by FGFR4 in disease";"Negative regulation of FGFR1 signaling";"GRB2 events in ERBB2 signaling";"PI3K events in ERBB2 signaling";"Signaling by FGFR3 fusions in cancer";"Interleukin receptor SHC signaling";"FCERI mediated Ca+2 mobilization";"SHC-mediated cascade:FGFR3";"Activated NTRK2 signals through RAS";"Regulation of actin dynamics for phagocytic cup formation";"FLT3 Signaling";"PI-3K cascade:FGFR4";"Constitutive Signaling by Overexpressed ERBB2";"Spry regulation of FGF signaling";"GRB2 events in EGFR signaling";"Role of LAT2/NTAL/LAB on calcium mobilization";"SHC-mediated cascade:FGFR4";"Signalling to RAS";"SHC-mediated cascade:FGFR2";"Constitutive Signaling by EGFRvIII";"Negative regulation of MET activity";"Activated NTRK2 signals through PI3K";"SHC1 events in ERBB2 signaling";"Activated NTRK3 signals through RAS";"EGFR downregulation";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Costimulation by the CD28 family";"PIP3 activates AKT signaling";"PI-3K cascade:FGFR2";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"InlB-mediated entry of Listeria monocytogenes into host cell";"SHC-mediated cascade:FGFR1";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB4 signaling";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"GAB1 signalosome";"MET activates RAS signaling";"SHC1 events in EGFR signaling";"FRS-mediated FGFR3 signaling";"Signaling by FGFR3 point mutants in cancer";"Tie2 Signaling";"FRS-mediated FGFR4 signaling";"MET activates PTPN11";"STAT5 Activation";"PI-3K cascade:FGFR3";"Regulation of KIT signaling";"Signal regulatory protein family interactions";"RHO GTPases Activate WASPs and WAVEs";"Insulin receptor signalling cascade";"CD28 dependent Vav1 pathway";"Regulation of signaling by CBL";"DAP12 signaling";"Interleukin-15 signaling";"SOS-mediated signalling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR2 signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"MET activates RAP1 and RAC1";"SHC-related events triggered by IGF1R";"Erythropoietin activates RAS";"Cargo recognition for clathrin-mediated endocytosis";"Negative regulation of FGFR3 signaling";"Signal attenuation";"Activated NTRK2 signals through FRS2 and FRS3";"Signaling by FGFR2 in disease";"MET activates PI3K/AKT signaling";"RET signaling";"EGFR Transactivation by Gastrin";"PI3K Cascade";"FCERI mediated MAPK activation";"Downstream signal transduction";"Signaling by cytosolic FGFR1 fusion mutants";"Negative regulation of FGFR4 signaling";"PI-3K cascade:FGFR1";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Signaling by FGFR1 in disease";"MET receptor recycling"
XP_053946022.1	10	MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-8053;MetaCyc: PWY-5667;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.15;Reactome: R-HSA-1483166;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.15;MetaCyc: PWY-7411	"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Synthesis of PA";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Phosphatidate biosynthesis (yeast)"
XP_053948580.1	4	Reactome: R-HSA-3000178;Reactome: R-HSA-2129379;Reactome: R-HSA-3000170;Reactome: R-HSA-216083	"ECM proteoglycans";"Molecules associated with elastic fibres";"Syndecan interactions";"Integrin cell surface interactions"
XP_053965384.1	3	Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053952840.1	4	Reactome: R-HSA-5696394;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823	"DNA Damage Recognition in GG-NER";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex"
XP_053953418.1	5	Reactome: R-HSA-201722;Reactome: R-HSA-8939243;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695;Reactome: R-HSA-3247509	"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines";"Interleukin-7 signaling";"Chromatin modifying enzymes"
XP_053952984.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_053945289.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
XP_053969154.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053951973.1	1	Reactome: R-HSA-71262	"Carnitine synthesis"
XP_053954346.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053945282.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053947704.1	3	MetaCyc: PWY-5697;KEGG: 00230+3.5.2.5;MetaCyc: PWY-5698	"Allantoin degradation to ureidoglycolate I (urea producing)";"Purine metabolism";"Allantoin degradation to ureidoglycolate II (ammonia producing)"
XP_053956669.1	4	Reactome: R-HSA-389661;Reactome: R-HSA-77289;Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Glyoxylate metabolism and glycine degradation";"Mitochondrial Fatty Acid Beta-Oxidation";"Complex I biogenesis";"Respiratory electron transport"
XP_053947084.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_053960900.1	13	Reactome: R-HSA-6802952;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6802955;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-9649948;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6802946;KEGG: 04151+2.7.11.1	"Signaling by BRAF and RAF fusions";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Relaxin signaling pathway";"mTOR signaling pathway";"Signaling downstream of RAS mutants";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Human papillomavirus infection";"Signaling by moderate kinase activity BRAF mutants";"PI3K-Akt signaling pathway"
XP_053957187.1	2	Reactome: R-HSA-430039;MetaCyc: PWY-6938	"mRNA decay by 5' to 3' exoribonuclease";"NADH repair"
XP_053946974.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053963721.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_053956662.1	4	Reactome: R-HSA-2022090;Reactome: R-HSA-1650814;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216	"Assembly of collagen fibrils and other multimeric structures";"Collagen biosynthesis and modifying enzymes";"Collagen degradation";"Collagen chain trimerization"
XP_053948959.1	1	Reactome: R-HSA-376172	"DSCAM interactions"
XP_053948212.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_053967458.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053954702.1	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
XP_053964453.1	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
XP_053950349.1	18	MetaCyc: PWY-7783;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482839;Reactome: R-HSA-1482801;MetaCyc: PWY-7417;MetaCyc: PWY-8053;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925	"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PE";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG"
XP_053963078.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053954743.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053954871.1	6	MetaCyc: PWY-4981;MetaCyc: PWY-6344;Reactome: R-HSA-8964539;KEGG: 00330+2.6.1.13;MetaCyc: PWY-3341;MetaCyc: PWY-6922	"L-proline biosynthesis II (from arginine)";"L-ornithine degradation II (Stickland reaction)";"Glutamate and glutamine metabolism";"Arginine and proline metabolism";"L-proline biosynthesis III (from L-ornithine)";"L-Ndelta-acetylornithine biosynthesis"
XP_053962999.1	7	Reactome: R-HSA-8856828;Reactome: R-HSA-1855204;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1660499	"Clathrin-mediated endocytosis";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the plasma membrane"
XP_053961826.1	3	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
XP_053966006.1	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
XP_053963285.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-5689603	"Ub-specific processing proteases";"UCH proteinases"
XP_053950873.1	5	Reactome: R-HSA-174403;Reactome: R-HSA-5579006;MetaCyc: PWY-8043;KEGG: 00270+6.3.2.3;KEGG: 00480+6.3.2.3	"Glutathione synthesis and recycling";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Ophthalmate biosynthesis";"Cysteine and methionine metabolism";"Glutathione metabolism"
XP_053964922.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_053958353.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053966415.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053964435.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053952388.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053951116.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053948423.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053951993.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_053966041.1	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
XP_053962111.1	3	Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160	"VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway";"Signal regulatory protein family interactions"
XP_053947412.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053955372.1	1	Reactome: R-HSA-4419969	"Depolymerisation of the Nuclear Lamina"
XP_053962283.1	5	Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-5628897;Reactome: R-HSA-75035;Reactome: R-HSA-5625740	"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"TP53 Regulates Metabolic Genes";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs"
XP_053968604.1	10	Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-3108214;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"SUMOylation of DNA damage response and repair proteins";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_053950138.1	4	KEGG: 00330+1.5.5.2;Reactome: R-HSA-70688;MetaCyc: PWY-6922;MetaCyc: PWY-5737	"Arginine and proline metabolism";"Proline catabolism";"L-Ndelta-acetylornithine biosynthesis";"(5R)-carbapenem carboxylate biosynthesis"
XP_053960926.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257	"RHO GTPases Activate Formins";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion"
XP_053946378.1	4	Reactome: R-HSA-1799339;Reactome: R-HSA-381771;Reactome: R-HSA-422085;Reactome: R-HSA-400511	"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"
XP_053962972.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053962979.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053961022.1	4	Reactome: R-HSA-196741;Reactome: R-HSA-3359462;Reactome: R-HSA-3359463;Reactome: R-HSA-8964011	"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective AMN causes hereditary megaloblastic anemia 1";"Defective CUBN causes hereditary megaloblastic anemia 1";"HDL clearance"
XP_053966802.1	4	Reactome: R-HSA-5419276;Reactome: R-HSA-1268020;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial protein import";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053964744.1	3	Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508	"G alpha (z) signalling events";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis"
XP_053950130.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_053965631.1	1	Reactome: R-HSA-9617828	"FOXO-mediated transcription of cell cycle genes"
XP_053963985.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053951165.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053966466.1	7	Reactome: R-HSA-5083629;Reactome: R-HSA-3000178;Reactome: R-HSA-9010553;Reactome: R-HSA-5083633;Reactome: R-HSA-5173105;Reactome: R-HSA-3000171;Reactome: R-HSA-5083628	"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"ECM proteoglycans";"Regulation of expression of SLITs and ROBOs";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"O-linked glycosylation";"Non-integrin membrane-ECM interactions";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3"
XP_053957098.1	17	MetaCyc: PWY-6620;MetaCyc: PWY-6644;KEGG: 00230+2.4.2.1;Reactome: R-HSA-74217;Reactome: R-HSA-6798695;MetaCyc: PWY-6627;MetaCyc: PWY-6611;MetaCyc: PWY-7179-1;Reactome: R-HSA-74259;MetaCyc: PWY-5695;MetaCyc: PWY-6608;KEGG: 00240+2.4.2.1;MetaCyc: PWY-4202;KEGG: 00760+2.4.2.1;MetaCyc: PWY-7179;MetaCyc: PWY-5532;MetaCyc: PWY-6609	"Guanine and guanosine salvage";"Fluoroacetate and fluorothreonine biosynthesis";"Purine metabolism";"Purine salvage";"Neutrophil degranulation";"Salinosporamide A biosynthesis";"Adenine and adenosine salvage V";"Purine deoxyribonucleosides degradation II";"Purine catabolism";"Inosine 5'-phosphate degradation";"Guanosine nucleotides degradation III";"Pyrimidine metabolism";"Arsenate detoxification I (mammalian)";"Nicotinate and nicotinamide metabolism";"Purine deoxyribonucleosides degradation I";"Nucleoside and nucleotide degradation (archaea)";"Adenine and adenosine salvage III"
XP_053950882.1	6	Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids"
XP_053945165.1	6	MetaCyc: PWY-5484;KEGG: 00010+5.4.2.11;MetaCyc: PWY-1622;KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;KEGG: 00680+5.4.2.11	"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation I (serine pathway)";"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Methane metabolism"
XP_053947395.1	4	KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-6483;MetaCyc: PWY-7119	"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)"
XP_053968250.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_053950889.1	4	MetaCyc: PWY-7375;Reactome: R-HSA-72086;Reactome: R-HSA-167160;Reactome: R-HSA-77075	"Mrna capping I";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE"
XP_053961398.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053962983.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950653.1	56	Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-69481;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-450408;Reactome: R-HSA-180534;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-9604323;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-349425;Reactome: R-HSA-5362768	"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"G2/M Checkpoints";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vpu mediated degradation of CD4";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Negative regulation of NOTCH4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of AXIN";"Hedgehog ligand biogenesis";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD"
XP_053962272.1	57	Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-69481;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-382556;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-6798695;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-4608870;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-9604323;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-202424	"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"G2/M Checkpoints";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"ABC-family proteins mediated transport";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Neutrophil degranulation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"Asymmetric localization of PCP proteins";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Negative regulation of NOTCH4 signaling";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Neddylation";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Degradation of AXIN";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling"
XP_053949497.1	4	Reactome: R-HSA-77075;Reactome: R-HSA-167160;MetaCyc: PWY-7375;Reactome: R-HSA-72086	"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Mrna capping I";"mRNA Capping"
XP_053959824.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053965669.1	3	Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300	"SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors"
XP_053957322.1	57	Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-6798695;Reactome: R-HSA-450408;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-69481;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-174184;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813	"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Neutrophil degranulation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"G2/M Checkpoints";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"Neddylation";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of AXIN";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids"
XP_053946826.1	4	KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174;Reactome: R-HSA-1237112;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053954886.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053962279.1	10	KEGG: 00051+2.7.1.11;KEGG: 00010+2.7.1.11;MetaCyc: PWY-7385;KEGG: 00052+2.7.1.11;MetaCyc: PWY-1042;Reactome: R-HSA-70171;MetaCyc: PWY-1861;KEGG: 00680+2.7.1.11;KEGG: 00030+2.7.1.11;MetaCyc: PWY-5484	"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)";"Galactose metabolism";"Glycolysis IV (plant cytosol)";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Methane metabolism";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)"
XP_053952380.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053967901.1	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
XP_053966392.1	6	Reactome: R-HSA-1483166;Reactome: R-HSA-163560;MetaCyc: PWY-6118;MetaCyc: PWY-6952;KEGG: 00564+1.1.5.3;MetaCyc: PWY-4261	"Synthesis of PA";"Triglyceride catabolism";"Glycerol-3-phosphate shuttle";"Glycerophosphodiester degradation";"Glycerophospholipid metabolism";"Glycerol degradation I"
XP_053949783.1	4	KEGG: 00260+4.2.1.22;MetaCyc: PWY-801;KEGG: 00270+4.2.1.22;Reactome: R-HSA-1614603	"Glycine, serine and threonine metabolism";"Homocysteine and cysteine interconversion";"Cysteine and methionine metabolism";"Cysteine formation from homocysteine"
XP_053952358.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053953142.1	3	Reactome: R-HSA-6782315;MetaCyc: PWY-6700;MetaCyc: PWY-8106	"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis I (de novo)";"Queuosine biosynthesis III (queuosine salvage)"
XP_053950819.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053949316.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053953149.1	17	Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-6790901;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-192823	"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"rRNA modification in the nucleus and cytosol";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation"
XP_053950812.1	2	Reactome: R-HSA-5576886;Reactome: R-HSA-1299308	"Phase 4 - resting membrane potential";"Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)"
XP_053949641.1	11	Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-418594;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-418597	"G alpha (s) signalling events";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Glucagon signaling in metabolic regulation";"G alpha (i) signalling events";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"G alpha (z) signalling events"
XP_053963255.1	6	KEGG: 00500+2.4.1.18;MetaCyc: PWY-622;Reactome: R-HSA-189085;KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;MetaCyc: PWY-7900	"Starch and sucrose metabolism";"Starch biosynthesis";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)"
XP_053960481.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053947361.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_053953768.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053967760.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053947339.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053959172.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053950679.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053962913.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053959911.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053953827.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_053959060.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_053951186.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053961247.1	2	Reactome: R-HSA-110320;Reactome: R-HSA-983168	"Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053946145.1	5	Reactome: R-HSA-8936459;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-3214841;Reactome: R-HSA-3769402	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines";"Deactivation of the beta-catenin transactivating complex"
XP_053956593.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053965589.1	2	Reactome: R-HSA-1221632;Reactome: R-HSA-5601884	"Meiotic synapsis";"PIWI-interacting RNA (piRNA) biogenesis"
XP_053945186.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053956897.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053964528.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053962860.1	7	KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053965567.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-1268020	"Cristae formation";"Mitochondrial protein import"
XP_053967149.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053966642.1	2	KEGG: 00071+2.3.1.21;MetaCyc: PWY-6111	"Fatty acid degradation";"Mitochondrial L-carnitine shuttle"
XP_053967142.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_053965657.1	6	Reactome: R-HSA-73933;Reactome: R-HSA-5651801;Reactome: R-HSA-73930;Reactome: R-HSA-110362;Reactome: R-HSA-110357;Reactome: R-HSA-110373	"Resolution of Abasic Sites (AP sites)";"PCNA-Dependent Long Patch Base Excision Repair";"Abasic sugar-phosphate removal via the single-nucleotide replacement pathway";"POLB-Dependent Long Patch Base Excision Repair";"Displacement of DNA glycosylase by APEX1";"Resolution of AP sites via the multiple-nucleotide patch replacement pathway"
XP_053968512.1	3	Reactome: R-HSA-1660662;KEGG: 00600+3.1.4.12;MetaCyc: PWY-7277	"Glycosphingolipid metabolism";"Sphingolipid metabolism";"Sphingolipid biosynthesis (mammals)"
XP_053966603.1	4	KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193;Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48	"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I";"Pyrimidine salvage";"Drug metabolism - other enzymes"
XP_053952350.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053967768.1	4	Reactome: R-HSA-912631;Reactome: R-HSA-8875555;Reactome: R-HSA-8875656;Reactome: R-HSA-186763	"Regulation of signaling by CBL";"MET activates RAP1 and RAC1";"MET receptor recycling";"Downstream signal transduction"
XP_053959951.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-983168	"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053949628.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053965950.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_053957915.1	20	Reactome: R-HSA-9033241;MetaCyc: PWY-6920;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-7288;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7854;MetaCyc: PWY-5136;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;KEGG: 00410+1.3.3.6;MetaCyc: PWY-6837;MetaCyc: PWY-7291;MetaCyc: PWY-7606;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7858;MetaCyc: PWY-7007	"Peroxisomal protein import";"6-gingerol analog biosynthesis (engineered)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Fatty acid degradation";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"beta-Alanine metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Propanoate metabolism";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"Methyl ketone biosynthesis (engineered)"
XP_053954865.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053947467.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism"
XP_053964499.1	17	Reactome: R-HSA-163765;MetaCyc: PWY-4381;Reactome: R-HSA-3371599;KEGG: 00720+6.4.1.2;MetaCyc: PWY-5744;Reactome: R-HSA-196780;Reactome: R-HSA-2426168;MetaCyc: PWY-5966-1;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6722;KEGG: 00620+6.4.1.2;MetaCyc: PWY-6679;MetaCyc: PWY-5789;KEGG: 00640+6.4.1.2;KEGG: 00254+6.4.1.2;MetaCyc: PWY-5743;Reactome: R-HSA-200425	"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (bacteria and plants)";"Defective HLCS causes multiple carboxylase deficiency";"Carbon fixation pathways in prokaryotes";"Glyoxylate assimilation";"Biotin transport and metabolism";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis";"Candicidin biosynthesis";"Pyruvate metabolism";"Jadomycin biosynthesis";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Propanoate metabolism";"Aflatoxin biosynthesis";"3-hydroxypropanoate cycle";"Carnitine metabolism"
XP_053964763.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053966864.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_053962953.1	3	MetaCyc: PWY-7420;Reactome: R-HSA-426048;KEGG: 00561+3.1.1.23	"Monoacylglycerol metabolism (yeast)";"Arachidonate production from DAG";"Glycerolipid metabolism"
XP_053967688.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_053961830.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053946916.1	2	KEGG: 00450+6.1.1.10;KEGG: 00970+6.1.1.10	"Selenocompound metabolism";"Aminoacyl-tRNA biosynthesis"
XP_053969429.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053953969.1	3	Reactome: R-HSA-5694530;Reactome: R-HSA-948021;Reactome: R-HSA-204005	"Cargo concentration in the ER";"Transport to the Golgi and subsequent modification";"COPII-mediated vesicle transport"
XP_053956545.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_053966571.1	3	Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621	"Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism"
XP_053950108.1	4	Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_053953962.1	13	KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52	"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Glycosphingolipid metabolism";"CS/DS degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation"
XP_053955403.1	1	Reactome: R-HSA-8964572	"Lipid particle organization"
XP_053949887.1	6	KEGG: 00760+6.3.5.1;MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807;MetaCyc: PWY-7761	"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD salvage pathway II (PNC IV cycle)"
XP_053950528.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053966063.1	6	Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_053949869.1	17	Reactome: R-HSA-937042;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-1169091;Reactome: R-HSA-9645460;Reactome: R-HSA-445989;Reactome: R-HSA-5607764;Reactome: R-HSA-450321;Reactome: R-HSA-9014325;Reactome: R-HSA-450302;Reactome: R-HSA-9020702;Reactome: R-HSA-4086398;Reactome: R-HSA-937072;Reactome: R-HSA-975163;Reactome: R-HSA-5689880;Reactome: R-HSA-202424;Reactome: R-HSA-2871837	"IRAK2 mediated activation of TAK1 complex";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"Activation of NF-kappaB in B cells";"Alpha-protein kinase 1 signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"CLEC7A (Dectin-1) signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"TICAM1,TRAF6-dependent induction of TAK1 complex";"activated TAK1 mediates p38 MAPK activation";"Interleukin-1 signaling";"Ca2+ pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"Ub-specific processing proteases";"Downstream TCR signaling";"FCERI mediated NF-kB activation"
XP_053964859.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053957146.1	1	Reactome: R-HSA-977347	"Serine biosynthesis"
XP_053961624.1	18	KEGG: 00400+2.6.1.1;KEGG: 00330+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00401+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00270+2.6.1.1;MetaCyc: PWY-7383;MetaCyc: PWY-6638;MetaCyc: PWY-7115;MetaCyc: PWY-6642;MetaCyc: PWY-5913;KEGG: 00220+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00960+2.6.1.1;MetaCyc: PWY-7117	"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine and proline metabolism";"Coenzyme M biosynthesis II";"Novobiocin biosynthesis";"Carbon fixation in photosynthetic organisms";"Cysteine and methionine metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Sulfolactate degradation III";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"(R)-cysteate degradation";"Partial TCA cycle (obligate autotrophs)";"Arginine biosynthesis";"Alanine, aspartate and glutamate metabolism";"Isoquinoline alkaloid biosynthesis";"Phenylalanine metabolism";"Tyrosine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"C4 photosynthetic carbon assimilation cycle, PEPCK type"
XP_053950047.1	4	Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862	"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053949644.1	11	Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-164378;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-418597;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-170670;Reactome: R-HSA-163615	"Hedgehog 'off' state";"G alpha (i) signalling events";"PKA activation in glucagon signalling";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events";"Purine metabolism";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway";"PKA activation"
XP_053956646.1	7	Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-73780	"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation"
XP_053968841.1	12	Reactome: R-HSA-72702;Reactome: R-HSA-72662;Reactome: R-HSA-450408;Reactome: R-HSA-975957;Reactome: R-HSA-166208;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-72649;Reactome: R-HSA-429947;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-1169408	"Ribosomal scanning and start codon recognition";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mTORC1-mediated signalling";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Deadenylation of mRNA";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"ISG15 antiviral mechanism"
XP_053958794.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053946216.1	1	Reactome: R-HSA-2028269	"Signaling by Hippo"
XP_053968009.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_053950777.1	12	Reactome: R-HSA-8849932;Reactome: R-HSA-438066;MetaCyc: PWY-7221;Reactome: R-HSA-451308;Reactome: R-HSA-447038;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;KEGG: 00230+2.7.4.8;Reactome: R-HSA-9620244;Reactome: R-HSA-399719;Reactome: R-HSA-442982;Reactome: R-HSA-9617324	"Synaptic adhesion-like molecules";"Unblocking of NMDA receptors, glutamate binding and activation";"Guanosine ribonucleotides de novo biosynthesis";"Activation of Ca-permeable Kainate Receptor";"NrCAM interactions";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"Purine metabolism";"Long-term potentiation";"Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission"
XP_053953287.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053953262.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053968002.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053963146.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053968767.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_053948468.1	11	KEGG: 00250+6.3.1.2;MetaCyc: PWY-381;MetaCyc: PWY-6549;KEGG: 00220+6.3.1.2;MetaCyc: PWY-6963;KEGG: 00910+6.3.1.2;Reactome: R-HSA-8964539;KEGG: 00630+6.3.1.2;MetaCyc: PWY-5675;MetaCyc: PWY-6964;Reactome: R-HSA-210455	"Alanine, aspartate and glutamate metabolism";"Nitrate reduction II (assimilatory)";"L-glutamine biosynthesis III";"Arginine biosynthesis";"Ammonia assimilation cycle I";"Nitrogen metabolism";"Glutamate and glutamine metabolism";"Glyoxylate and dicarboxylate metabolism";"Nitrate reduction V (assimilatory)";"Ammonia assimilation cycle II";"Astrocytic Glutamate-Glutamine Uptake And Metabolism"
XP_053953231.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053962629.1	13	KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;KEGG: 00603+3.2.1.52;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;KEGG: 00511+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52	"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Chitin degradation III (Serratia)";"CS/DS degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Other glycan degradation";"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
XP_053961838.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053952199.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_053958565.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053967680.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_053959907.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053949033.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053950100.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053967987.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053959600.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6784531	"Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus"
XP_053964819.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053965789.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053956469.1	3	KEGG: 04070+3.1.3.78;MetaCyc: PWY-6367;MetaCyc: PWY-6368	"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"3-phosphoinositide degradation"
XP_053953957.1	4	MetaCyc: PWY-5188;MetaCyc: PWY-5189;KEGG: 00860+2.5.1.61;Reactome: R-HSA-189451	"Tetrapyrrole biosynthesis I (from glutamate)";"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis"
XP_053960886.1	3	KEGG: 00860+1.3.3.3;Reactome: R-HSA-189451;MetaCyc: PWY-7159	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"
XP_053964728.1	3	Reactome: R-HSA-418597;Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13	"G alpha (z) signalling events";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_053961159.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053945468.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
XP_053945245.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053967204.1	10	MetaCyc: PWY-5497;MetaCyc: PWY-6613;MetaCyc: PWY-7909;Reactome: R-HSA-196757;MetaCyc: PWY-2201;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-1722;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;MetaCyc: PWY-5030	"Purine nucleobases degradation II (anaerobic)";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"Metabolism of folate and pterines";"Folate transformations I";"One carbon pool by folate";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"L-histidine degradation III"
XP_053953650.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-375276	"G alpha (i) signalling events";"Peptide ligand-binding receptors"
XP_053959284.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053951468.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053947309.1	3	Reactome: R-HSA-1660516;Reactome: R-HSA-1660514;Reactome: R-HSA-1660517	"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the late endosome membrane"
XP_053954226.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053952135.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053955556.1	11	Reactome: R-HSA-174430;Reactome: R-HSA-110314;Reactome: R-HSA-68962;Reactome: R-HSA-5696400;Reactome: R-HSA-68952;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-5685942;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801	"Telomere C-strand synthesis initiation";"Recognition of DNA damage by PCNA-containing replication complex";"Activation of the pre-replicative complex";"Dual Incision in GG-NER";"DNA replication initiation";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair"
XP_053956806.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_053962021.1	4	Reactome: R-HSA-1912420;Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Pre-NOTCH Processing in Golgi";"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
XP_053956396.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053967568.1	5	Reactome: R-HSA-9033500;MetaCyc: PWY-7782;Reactome: R-HSA-9033241;KEGG: 00565+2.5.1.26;Reactome: R-HSA-75896	"TYSND1 cleaves peroxisomal proteins";"Plasmalogen biosynthesis";"Peroxisomal protein import";"Ether lipid metabolism";"Plasmalogen biosynthesis"
XP_053958591.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053964867.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053969292.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053955655.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053953618.1	1	Reactome: R-HSA-2565942	"Regulation of PLK1 Activity at G2/M Transition"
XP_053949857.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_053959848.1	4	Reactome: R-HSA-419037;Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-112308	"NCAM1 interactions";"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"Presynaptic depolarization and calcium channel opening"
XP_053953917.1	4	Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-8953750;Reactome: R-HSA-1362277	"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"Transcriptional Regulation by E2F6";"Transcription of E2F targets under negative control by DREAM complex"
XP_053962527.1	1	Reactome: R-HSA-8851805	"MET activates RAS signaling"
XP_053961112.1	3	Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916	"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium"
XP_053967904.1	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
XP_053959840.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053965841.1	6	Reactome: R-HSA-6798695;Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Neutrophil degranulation";"Ion channel transport";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
XP_053954317.1	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
XP_053959984.1	4	KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3	"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism"
XP_053966118.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-426486	"MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis"
XP_053961971.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_053964613.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053947076.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053964720.1	3	KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508;Reactome: R-HSA-418597	"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"G alpha (z) signalling events"
XP_053953723.1	6	Reactome: R-HSA-3769402;Reactome: R-HSA-8951664;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-201722;Reactome: R-HSA-5617472	"Deactivation of the beta-catenin transactivating complex";"Neddylation";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
XP_053953204.1	2	Reactome: R-HSA-5689880;MetaCyc: PWY-7511	"Ub-specific processing proteases";"Protein ubiquitination"
XP_053958586.1	3	Reactome: R-HSA-8963684;KEGG: 00350+1.13.11.5;KEGG: 00643+1.13.11.5	"Tyrosine catabolism";"Tyrosine metabolism";"Styrene degradation"
XP_053950435.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053958449.1	17	MetaCyc: PWY-5913;MetaCyc: PWY-6728;MetaCyc: PWY-7115;KEGG: 00020+1.1.1.37;MetaCyc: PWY-561;MetaCyc: PWY-8086;KEGG: 00620+1.1.1.37;KEGG: 00270+1.1.1.37;KEGG: 00710+1.1.1.37;MetaCyc: PWY-6969;MetaCyc: PWY-5392;KEGG: 00630+1.1.1.37;MetaCyc: PWY-7383;MetaCyc: PWY-5690;KEGG: 00720+1.1.1.37;MetaCyc: PWY-1622;KEGG: 00680+1.1.1.37	"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Citrate cycle (TCA cycle)";"Superpathway of glyoxylate cycle and fatty acid degradation";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Cysteine and methionine metabolism";"Carbon fixation in photosynthetic organisms";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"Glyoxylate and dicarboxylate metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"TCA cycle II (plants and fungi)";"Carbon fixation pathways in prokaryotes";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism"
XP_053966150.1	5	Reactome: R-HSA-3656237;KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-3656253;Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"Defective EXT2 causes exostoses 2";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_053965376.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053964873.1	3	MetaCyc: PWY-6317;KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3	"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Glycolysis / Gluconeogenesis"
XP_053950929.1	3	Reactome: R-HSA-2408508;Reactome: R-HSA-1614603;Reactome: R-HSA-1614558	"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Cysteine formation from homocysteine";"Degradation of cysteine and homocysteine"
XP_053962107.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053950501.1	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
XP_053954377.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053949617.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_053967850.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex"
XP_053953263.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053961251.1	2	Reactome: R-HSA-110320;Reactome: R-HSA-983168	"Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053962710.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053967678.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053949250.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_053963625.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
XP_053958464.1	7	Reactome: R-HSA-9020265;Reactome: R-HSA-9018681;Reactome: R-HSA-6798695;Reactome: R-HSA-2142691;Reactome: R-HSA-9018896;Reactome: R-HSA-9018676;Reactome: R-HSA-9023661	"Biosynthesis of aspirin-triggered D-series resolvins";"Biosynthesis of protectins";"Neutrophil degranulation";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Biosynthesis of E-series 18(S)-resolvins";"Biosynthesis of D-series resolvins";"Biosynthesis of E-series 18(R)-resolvins"
XP_053949061.1	10	MetaCyc: PWY-7849;MetaCyc: PWY-7394;MetaCyc: PWY-5691;Reactome: R-HSA-2453902;KEGG: 00230+3.5.2.17;Reactome: R-HSA-2453864;Reactome: R-HSA-6798695;Reactome: R-HSA-977225;Reactome: R-HSA-975634;Reactome: R-HSA-3000171	"Urate conversion to allantoin III";"Urate conversion to allantoin II";"Urate conversion to allantoin I";"The canonical retinoid cycle in rods (twilight vision)";"Purine metabolism";"Retinoid cycle disease events";"Neutrophil degranulation";"Amyloid fiber formation";"Retinoid metabolism and transport";"Non-integrin membrane-ECM interactions"
XP_053967963.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053954715.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053952448.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053966537.1	3	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
XP_053949039.1	3	KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596	"Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I"
XP_053965641.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053950140.1	4	Reactome: R-HSA-70688;KEGG: 00330+1.5.5.2;MetaCyc: PWY-5737;MetaCyc: PWY-6922	"Proline catabolism";"Arginine and proline metabolism";"(5R)-carbapenem carboxylate biosynthesis";"L-Ndelta-acetylornithine biosynthesis"
XP_053964734.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053952256.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053955190.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_053949958.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_053950121.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis"
XP_053965620.1	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_053964504.1	5	KEGG: 00785+2.3.1.181;Reactome: R-HSA-389661;KEGG: 00785+6.3.1.20;MetaCyc: PWY-6987;MetaCyc: PWY-7382	"Lipoic acid metabolism";"Glyoxylate metabolism and glycine degradation";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoate biosynthesis and incorporation IV (yeast)"
XP_053964960.1	20	MetaCyc: PWY-6837;MetaCyc: PWY-7291;MetaCyc: PWY-7606;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7858;MetaCyc: PWY-7007;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7288;KEGG: 00071+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7854;MetaCyc: PWY-7574;MetaCyc: PWY-7337;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;Reactome: R-HSA-9033241;MetaCyc: PWY-6920;MetaCyc: PWY-7340;MetaCyc: PWY-7726	"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Propanoate metabolism";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"Methyl ketone biosynthesis (engineered)";"beta-Alanine metabolism";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Fatty acid degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"Peroxisomal protein import";"6-gingerol analog biosynthesis (engineered)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"
XP_053962174.1	20	Reactome: R-HSA-5656121;Reactome: R-HSA-110320;Reactome: R-HSA-6804756;Reactome: R-HSA-5655862;Reactome: R-HSA-176187;Reactome: R-HSA-5685938;Reactome: R-HSA-110314;Reactome: R-HSA-5693607;Reactome: R-HSA-5696400;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-5651801;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-69091;Reactome: R-HSA-6782135	"Translesion synthesis by POLI";"Translesion Synthesis by POLH";"Regulation of TP53 Activity through Phosphorylation";"Translesion synthesis by POLK";"Activation of ATR in response to replication stress";"HDR through Single Strand Annealing (SSA)";"Recognition of DNA damage by PCNA-containing replication complex";"Processing of DNA double-strand break ends";"Dual Incision in GG-NER";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"Polymerase switching";"Dual incision in TC-NER"
XP_053955402.1	4	Reactome: R-HSA-8934903;Reactome: R-HSA-936440;Reactome: R-HSA-1632852;Reactome: R-HSA-5205685	"Receptor Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling";"Macroautophagy";"Pink/Parkin Mediated Mitophagy"
XP_053947065.1	57	Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-9604323;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4641257;Reactome: R-HSA-382556;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-174178;Reactome: R-HSA-532668;Reactome: R-HSA-4608870;Reactome: R-HSA-450408;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-5658442	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Downstream TCR signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"Negative regulation of NOTCH4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of AXIN";"ABC-family proteins mediated transport";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Asymmetric localization of PCP proteins";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Regulation of RAS by GAPs"
XP_053949950.1	7	MetaCyc: PWY-6840;MetaCyc: PWY-8043;MetaCyc: PWY-7255;KEGG: 00480+6.3.2.2;Reactome: R-HSA-174403;Reactome: R-HSA-5578999;KEGG: 00270+6.3.2.2	"Homoglutathione biosynthesis";"Ophthalmate biosynthesis";"Ergothioneine biosynthesis I (bacteria)";"Glutathione metabolism";"Glutathione synthesis and recycling";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Cysteine and methionine metabolism"
XP_053948790.1	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_053964667.1	5	Reactome: R-HSA-6804757;Reactome: R-HSA-5218920;Reactome: R-HSA-1257604;Reactome: R-HSA-389357;Reactome: R-HSA-5674400	"Regulation of TP53 Degradation";"VEGFR2 mediated vascular permeability";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling";"Constitutive Signaling by AKT1 E17K in Cancer"
XP_053960585.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053952421.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-159230;Reactome: R-HSA-77588	"RNA Polymerase II Transcription Termination";"Transport of the SLBP Dependant Mature mRNA";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"
XP_053964689.1	3	KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508;Reactome: R-HSA-418597	"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"G alpha (z) signalling events"
XP_053967670.1	7	KEGG: 00195+7.1.2.2;Reactome: R-HSA-163210;MetaCyc: PWY-7980;Reactome: R-HSA-1268020;Reactome: R-HSA-8949613;Reactome: R-HSA-2151201;KEGG: 00190+7.1.2.2	"Photosynthesis";"Formation of ATP by chemiosmotic coupling";"ATP biosynthesis";"Mitochondrial protein import";"Cristae formation";"Transcriptional activation of mitochondrial biogenesis";"Oxidative phosphorylation"
XP_053954471.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053956606.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053964445.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053967263.1	2	Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198	"Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"
XP_053952965.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053950731.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053968772.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053966170.1	1	Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis"
XP_053954755.1	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
XP_053952956.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053959247.1	22	Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-6811558;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-2500257;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337	"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Resolution of Sister Chromatid Cohesion";"Beta-catenin phosphorylation cascade";"RAF activation";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding"
XP_053966062.1	6	Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884	"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I"
XP_053966695.1	6	Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-111367;Reactome: R-HSA-72163;Reactome: R-HSA-191859;Reactome: R-HSA-72165	"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Major Pathway";"snRNP Assembly";"mRNA Splicing - Minor Pathway"
XP_053952216.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling"
XP_053966069.1	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053966551.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053968356.1	4	Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193	"Pyrimidine salvage";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I"
XP_053962008.1	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
XP_053960515.1	42	Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-912446;Reactome: R-HSA-9018519;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-5334118;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-3214815;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-427413;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-2299718;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-110331;Reactome: R-HSA-5693607;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-5578749;Reactome: R-HSA-427359	"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Meiotic recombination";"Estrogen-dependent gene expression";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"DNA methylation";"Meiotic synapsis";"Packaging Of Telomere Ends";"HDACs deacetylate histones";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"NoRC negatively regulates rRNA expression";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"Condensation of Prophase Chromosomes";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Cleavage of the damaged purine";"Processing of DNA double-strand break ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression"
XP_053964612.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053951905.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053947536.1	30	Reactome: R-HSA-5684264;Reactome: R-HSA-2644606;Reactome: R-HSA-5610783;Reactome: R-HSA-2894862;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-2644607;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837;Reactome: R-HSA-2122947;Reactome: R-HSA-69231;Reactome: R-HSA-202424;Reactome: R-HSA-2565942;Reactome: R-HSA-5610780;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-1170546;Reactome: R-HSA-917937;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-9604323;Reactome: R-HSA-400253;Reactome: R-HSA-8951664;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-187577	"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Degradation of GLI2 by the proteasome";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"NOTCH1 Intracellular Domain Regulates Transcription";"Cyclin D associated events in G1";"Downstream TCR signaling";"Regulation of PLK1 Activity at G2/M Transition";"Degradation of GLI1 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Prolactin receptor signaling";"Iron uptake and transport";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Negative regulation of NOTCH4 signaling";"Circadian Clock";"Neddylation";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21"
XP_053968227.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053961638.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053945905.1	1	Reactome: R-HSA-8943724	"Regulation of PTEN gene transcription"
XP_053964081.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053946276.1	5	KEGG: 00520+2.6.1.16;KEGG: 00250+2.6.1.16;MetaCyc: PWY-8013;MetaCyc: PWY-6749;Reactome: R-HSA-446210	"Amino sugar and nucleotide sugar metabolism";"Alanine, aspartate and glutamate metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis III";"CMP-legionaminate biosynthesis I";"Synthesis of UDP-N-acetyl-glucosamine"
XP_053961113.1	3	Reactome: R-HSA-1445148;Reactome: R-HSA-264876;Reactome: R-HSA-5620916	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing";"VxPx cargo-targeting to cilium"
XP_053959274.1	179	Reactome: R-HSA-156902;Reactome: R-HSA-174084;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-175474;Reactome: R-HSA-4641258;Reactome: R-HSA-450302;Reactome: R-HSA-3322077;Reactome: R-HSA-5610785;Reactome: R-HSA-2565942;Reactome: R-HSA-4641263;Reactome: R-HSA-5654732;Reactome: R-HSA-977225;Reactome: R-HSA-9613829;Reactome: R-HSA-9636383;Reactome: R-HSA-2122948;Reactome: R-HSA-2173791;Reactome: R-HSA-69541;Reactome: R-HSA-6781827;Reactome: R-HSA-174154;Reactome: R-HSA-6781823;Reactome: R-HSA-5689901;Reactome: R-HSA-5654727;Reactome: R-HSA-162588;Reactome: R-HSA-211733;Reactome: R-HSA-5654726;Reactome: R-HSA-5658442;Reactome: R-HSA-1236974;Reactome: R-HSA-5689877;Reactome: R-HSA-9033241;Reactome: R-HSA-69601;Reactome: R-HSA-8948747;Reactome: R-HSA-445989;Reactome: R-HSA-182971;Reactome: R-HSA-5687128;Reactome: R-HSA-1358803;Reactome: R-HSA-6807004;Reactome: R-HSA-975163;Reactome: R-HSA-69017;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-8849469;Reactome: R-HSA-8875360;Reactome: R-HSA-4608870;Reactome: R-HSA-532668;Reactome: R-HSA-8876493;Reactome: R-HSA-6791226;Reactome: R-HSA-2173788;Reactome: R-HSA-2173795;Reactome: R-HSA-5689603;Reactome: R-HSA-8951664;Reactome: R-HSA-72706;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-8866652;Reactome: R-HSA-205043;Reactome: R-HSA-6804756;Reactome: R-HSA-6804757;Reactome: R-HSA-156827;Reactome: R-HSA-180585;Reactome: R-HSA-174490;Reactome: R-HSA-2559580;Reactome: R-HSA-6783310;Reactome: R-HSA-5685942;Reactome: R-HSA-975110;Reactome: R-HSA-450321;Reactome: R-HSA-174184;Reactome: R-HSA-936964;Reactome: R-HSA-3769402;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-202424;Reactome: R-HSA-168928;Reactome: R-HSA-9645460;Reactome: R-HSA-195253;Reactome: R-HSA-5696394;Reactome: R-HSA-975956;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-400253;Reactome: R-HSA-110314;Reactome: R-HSA-5656121;Reactome: R-HSA-937039;Reactome: R-HSA-5684264;Reactome: R-HSA-9020702;Reactome: R-HSA-1253288;Reactome: R-HSA-9013973;Reactome: R-HSA-912631;Reactome: R-HSA-9604323;Reactome: R-HSA-209543;Reactome: R-HSA-5357905;Reactome: R-HSA-5693607;Reactome: R-HSA-8948751;Reactome: R-HSA-9014325;Reactome: R-HSA-5675482;Reactome: R-HSA-5696400;Reactome: R-HSA-5205685;Reactome: R-HSA-9615710;Reactome: R-HSA-2408557;Reactome: R-HSA-5689896;Reactome: R-HSA-9010553;Reactome: R-HSA-6782210;Reactome: R-HSA-5654733;Reactome: R-HSA-192823;Reactome: R-HSA-5693565;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-936440;Reactome: R-HSA-6804760;Reactome: R-HSA-975957;Reactome: R-HSA-69481;Reactome: R-HSA-5357956;Reactome: R-HSA-1169091;Reactome: R-HSA-6782135;Reactome: R-HSA-5675221;Reactome: R-HSA-8939902;Reactome: R-HSA-917729;Reactome: R-HSA-1295596;Reactome: R-HSA-209560;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-937072;Reactome: R-HSA-9013507;Reactome: R-HSA-72764;Reactome: R-HSA-201681;Reactome: R-HSA-2559585;Reactome: R-HSA-1236382;Reactome: R-HSA-2173796;Reactome: R-HSA-5696395;Reactome: R-HSA-382556;Reactome: R-HSA-5655862;Reactome: R-HSA-180534;Reactome: R-HSA-9633012;Reactome: R-HSA-2691232;Reactome: R-HSA-68949;Reactome: R-HSA-110312;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-168638;Reactome: R-HSA-2979096;Reactome: R-HSA-2672351;Reactome: R-HSA-901032;Reactome: R-HSA-937042;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-8856825;Reactome: R-HSA-2559582;Reactome: R-HSA-3785653;Reactome: R-HSA-975144;Reactome: R-HSA-174048;Reactome: R-HSA-8863795;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-2871837;Reactome: R-HSA-2122947;Reactome: R-HSA-69231;Reactome: R-HSA-917937;Reactome: R-HSA-983168;Reactome: R-HSA-1169408;Reactome: R-HSA-8856828;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-8866654;Reactome: R-HSA-168927;Reactome: R-HSA-3134975;Reactome: R-HSA-174178;Reactome: R-HSA-72689;Reactome: R-HSA-179409;Reactome: R-HSA-5610780;Reactome: R-HSA-9637628;Reactome: R-HSA-5610783;Reactome: R-HSA-1799339;Reactome: R-HSA-937041;Reactome: R-HSA-9646399;Reactome: R-HSA-110320	"Peptide chain elongation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"Assembly Of The HIV Virion";"Degradation of DVL";"activated TAK1 mediates p38 MAPK activation";"Glycogen synthesis";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PLK1 Activity at G2/M Transition";"Regulation of FZD by ubiquitination";"Negative regulation of FGFR3 signaling";"Amyloid fiber formation";"Chaperone Mediated Autophagy";"Prevention of phagosomal-lysosomal fusion";"Activated NOTCH1 Transmits Signal to the Nucleus";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Stabilization of p53";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"APC/C:Cdc20 mediated degradation of Securin";"Formation of TC-NER Pre-Incision Complex";"Metalloprotease DUBs";"Negative regulation of FGFR2 signaling";"Budding and maturation of HIV virion";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Negative regulation of FGFR1 signaling";"Regulation of RAS by GAPs";"ER-Phagosome pathway";"Josephin domain DUBs";"Peroxisomal protein import";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of PTEN localization";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"EGFR downregulation";"MAPK6/MAPK4 signaling";"Downregulation of ERBB2:ERBB3 signaling";"Negative regulation of MET activity";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"InlB-mediated entry of Listeria monocytogenes into host cell";"Asymmetric localization of PCP proteins";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"InlA-mediated entry of Listeria monocytogenes into host cells";"Major pathway of rRNA processing in the nucleolus and cytosol";"Downregulation of TGF-beta receptor signaling";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"UCH proteinases";"Neddylation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"NRIF signals cell death from the nucleus";"Regulation of TP53 Activity through Phosphorylation";"Regulation of TP53 Degradation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Vif-mediated degradation of APOBEC3G";"Membrane binding and targetting of GAG proteins";"Oxidative Stress Induced Senescence";"Fanconi Anemia Pathway";"HDR through Homologous Recombination (HRR)";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Deactivation of the beta-catenin transactivating complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Downstream TCR signaling";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Alpha-protein kinase 1 signaling pathway";"Degradation of beta-catenin by the destruction complex";"DNA Damage Recognition in GG-NER";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"Circadian Clock";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLI";"IRAK1 recruits IKK complex";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Interleukin-1 signaling";"Downregulation of ERBB4 signaling";"TICAM1-dependent activation of IRF3/IRF7";"Regulation of signaling by CBL";"Negative regulation of NOTCH4 signaling";"p75NTR recruits signalling complexes";"Regulation of TNFR1 signaling";"Processing of DNA double-strand break ends";"Regulation of PTEN stability and activity";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Regulation of necroptotic cell death";"Dual Incision in GG-NER";"Pink/Parkin Mediated Mitophagy";"Late endosomal microautophagy";"Selenocysteine synthesis";"Ovarian tumor domain proteases";"Regulation of expression of SLITs and ROBOs";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Negative regulation of FGFR4 signaling";"Viral mRNA Translation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"Negative regulators of DDX58/IFIH1 signaling";"Regulation of TP53 Activity through Methylation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"G2/M Checkpoints";"TNFR1-induced NFkappaB signaling pathway";"Activation of NF-kappaB in B cells";"Dual incision in TC-NER";"Negative regulation of MAPK pathway";"Regulation of RUNX2 expression and activity";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Spry regulation of FGF signaling";"NF-kB is activated and signals survival";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Eukaryotic Translation Termination";"TCF dependent signaling in response to WNT";"Oncogene Induced Senescence";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of Incision Complex in GG-NER";"ABC-family proteins mediated transport";"Translesion synthesis by POLK";"Vpu mediated degradation of CD4";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Orc1 removal from chromatin";"Translesion synthesis by REV1";"Degradation of AXIN";"Hedgehog ligand biogenesis";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"NOD1/2 Signaling Pathway";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Stimuli-sensing channels";"ER Quality Control Compartment (ERQC)";"IRAK2 mediated activation of TAK1 complex";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cargo recognition for clathrin-mediated endocytosis";"Senescence-Associated Secretory Phenotype (SASP)";"Myoclonic epilepsy of Lafora";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"APC/C:Cdc20 mediated degradation of Cyclin B";"Downregulation of ERBB2 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"FCERI mediated NF-kB activation";"NOTCH1 Intracellular Domain Regulates Transcription";"Cyclin D associated events in G1";"Iron uptake and transport";"Antigen processing: Ubiquitination & Proteasome degradation";"ISG15 antiviral mechanism";"Clathrin-mediated endocytosis";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"E3 ubiquitin ligases ubiquitinate target proteins";"TICAM1, RIP1-mediated IKK complex recruitment";"Regulation of innate immune responses to cytosolic DNA";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Formation of a pool of free 40S subunits";"APC-Cdc20 mediated degradation of Nek2A";"Degradation of GLI1 by the proteasome";"Modulation by Mtb of host immune system";"Degradation of GLI2 by the proteasome";"SRP-dependent cotranslational protein targeting to membrane";"IKK complex recruitment mediated by RIP1";"Aggrephagy";"Translesion Synthesis by POLH"
XP_053961281.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053949512.1	1	Reactome: R-HSA-420029	"Tight junction interactions"
XP_053950375.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053950923.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053961237.1	4	Reactome: R-HSA-5250958;Reactome: R-HSA-8856825;Reactome: R-HSA-6794361;Reactome: R-HSA-8856828	"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis";"Neurexins and neuroligins";"Clathrin-mediated endocytosis"
XP_053964872.1	3	KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3	"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis"
XP_053966017.1	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
XP_053952991.1	15	Reactome: R-HSA-2173796;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-9018519;Reactome: R-HSA-6807505;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-176034;Reactome: R-HSA-674695;Reactome: R-HSA-6796648	"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Estrogen-dependent gene expression";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Interactions of Tat with host cellular proteins";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes"
XP_053949519.1	11	KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-4420097;Reactome: R-HSA-450302;Reactome: R-HSA-2559580;Reactome: R-HSA-171007;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"VEGFA-VEGFR2 Pathway";"activated TAK1 mediates p38 MAPK activation";"Oxidative Stress Induced Senescence";"p38MAPK events";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053947635.1	14	MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876	"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs"
XP_053964701.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053953722.1	5	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-6811438;Reactome: R-HSA-204005;Reactome: R-HSA-6811434	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"Intra-Golgi traffic";"COPII-mediated vesicle transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053959390.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053953244.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053954005.1	4	Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-5625970;Reactome: R-HSA-2132295	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"RHO GTPases activate KTN1";"MHC class II antigen presentation"
XP_053947342.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053949844.1	3	Reactome: R-HSA-446193;Reactome: R-HSA-4724325;KEGG: 00510+2.4.1.265	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG8 causes ALG8-CDG (CDG-1h)";"N-Glycan biosynthesis"
XP_053966511.1	22	Reactome: R-HSA-6798695;MetaCyc: PWY-6981;MetaCyc: PWY-7238;MetaCyc: PWY-6142;MetaCyc: PWY-7347;MetaCyc: PWY-621;KEGG: 00500+5.3.1.9;MetaCyc: PWY-622;MetaCyc: PWY-7385;MetaCyc: PWY-8013;Reactome: R-HSA-70263;MetaCyc: PWY-6992;MetaCyc: PWY-5659;KEGG: 00030+5.3.1.9;KEGG: 00520+5.3.1.9;MetaCyc: PWY-5384;MetaCyc: PWY-5054;Reactome: R-HSA-5628897;KEGG: 00010+5.3.1.9;Reactome: R-HSA-70171;MetaCyc: PWY-3801;MetaCyc: PWY-5514	"Neutrophil degranulation";"Chitin biosynthesis";"Sucrose biosynthesis II";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Sucrose biosynthesis III";"Sucrose degradation III (sucrose invertase)";"Starch and sucrose metabolism";"Starch biosynthesis";"1,3-propanediol biosynthesis (engineered)";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Gluconeogenesis";"1,5-anhydrofructose degradation";"GDP-mannose biosynthesis";"Pentose phosphate pathway";"Amino sugar and nucleotide sugar metabolism";"Sucrose degradation IV (sucrose phosphorylase)";"D-sorbitol biosynthesis I";"TP53 Regulates Metabolic Genes";"Glycolysis / Gluconeogenesis";"Glycolysis";"Sucrose degradation II (sucrose synthase)";"UDP-N-acetyl-D-galactosamine biosynthesis II"
XP_053966004.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_053950757.1	3	Reactome: R-HSA-8964058;Reactome: R-HSA-1369062;Reactome: R-HSA-9029569	"HDL remodeling";"ABC transporters in lipid homeostasis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_053961153.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053960566.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053967722.1	30	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-198323;Reactome: R-HSA-6804759;Reactome: R-HSA-392451;Reactome: R-HSA-6804758;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-8948751;Reactome: R-HSA-389513;KEGG: 04151+2.7.11.1;Reactome: R-HSA-8876198;Reactome: R-HSA-111447;Reactome: R-HSA-69202;Reactome: R-HSA-199418;Reactome: R-HSA-9614399;Reactome: R-HSA-389357;Reactome: R-HSA-9634638;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 05165+2.7.11.1;Reactome: R-HSA-1257604;Reactome: R-HSA-1358803;Reactome: R-HSA-211163;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69656;Reactome: R-HSA-5674400;Reactome: R-HSA-8941332;Reactome: R-HSA-198693	"Thermogenesis";"Human immunodeficiency virus 1 infection";"AKT phosphorylates targets in the cytosol";"Regulation of TP53 Activity through Association with Co-factors";"G beta:gamma signalling through PI3Kgamma";"Regulation of TP53 Activity through Acetylation";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"Regulation of PTEN stability and activity";"CTLA4 inhibitory signaling";"PI3K-Akt signaling pathway";"RAB GEFs exchange GTP for GDP on RABs";"Activation of BAD and translocation to mitochondria";"Cyclin E associated events during G1/S transition";"Negative regulation of the PI3K/AKT network";"Regulation of localization of FOXO transcription factors";"CD28 dependent PI3K/Akt signaling";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Human cytomegalovirus infection";"mTOR signaling pathway";"TP53 Regulates Metabolic Genes";"Human papillomavirus infection";"PIP3 activates AKT signaling";"Downregulation of ERBB2:ERBB3 signaling";"AKT-mediated inactivation of FOXO1A";"Relaxin signaling pathway";"Cyclin A:Cdk2-associated events at S phase entry";"Constitutive Signaling by AKT1 E17K in Cancer";"RUNX2 regulates genes involved in cell migration";"AKT phosphorylates targets in the nucleus"
XP_053966057.1	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_053949631.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053969293.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053966345.1	2	KEGG: 04070+2.7.11.13;Reactome: R-HSA-5625740	"Phosphatidylinositol signaling system";"RHO GTPases activate PKNs"
XP_053950704.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053959808.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053965049.1	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
XP_053949552.1	6	MetaCyc: PWY-6368;Reactome: R-HSA-194840;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1855183;Reactome: R-HSA-1855204	"3-phosphoinositide degradation";"Rho GTPase cycle";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of IP3 and IP4 in the cytosol"
XP_053962000.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_053958815.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053947893.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053960099.1	1	Reactome: R-HSA-8964038	"LDL clearance"
XP_053966784.1	83	Reactome: R-HSA-210993;Reactome: R-HSA-5654712;Reactome: R-HSA-8865999;Reactome: R-HSA-9645135;Reactome: R-HSA-5654706;Reactome: R-HSA-8853338;Reactome: R-HSA-1433559;Reactome: R-HSA-74751;Reactome: R-HSA-389359;Reactome: R-HSA-391160;Reactome: R-HSA-5663213;Reactome: R-HSA-912631;Reactome: R-HSA-5654710;Reactome: R-HSA-2424491;Reactome: R-HSA-112412;Reactome: R-HSA-6811558;Reactome: R-HSA-5654693;Reactome: R-HSA-5654700;Reactome: R-HSA-983695;Reactome: R-HSA-8875555;Reactome: R-HSA-8983432;Reactome: R-HSA-74749;Reactome: R-HSA-9028731;Reactome: R-HSA-2428933;Reactome: R-HSA-8856825;Reactome: R-HSA-9027284;Reactome: R-HSA-5654732;Reactome: R-HSA-8851907;Reactome: R-HSA-5655253;Reactome: R-HSA-8853659;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-186763;Reactome: R-HSA-2871796;Reactome: R-HSA-5655302;Reactome: R-HSA-8875656;Reactome: R-HSA-1839117;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-2219530;Reactome: R-HSA-512988;Reactome: R-HSA-5655291;Reactome: R-HSA-5654726;Reactome: R-HSA-1963640;Reactome: R-HSA-5654727;Reactome: R-HSA-8856828;Reactome: R-HSA-1433557;Reactome: R-HSA-2871809;Reactome: R-HSA-5654704;Reactome: R-HSA-1963642;Reactome: R-HSA-8853334;Reactome: R-HSA-912526;Reactome: R-HSA-9026519;Reactome: R-HSA-2029482;Reactome: R-HSA-2730905;Reactome: R-HSA-5654719;Reactome: R-HSA-167044;Reactome: R-HSA-5654699;Reactome: R-HSA-5637810;Reactome: R-HSA-9607240;Reactome: R-HSA-9634285;Reactome: R-HSA-5654720;Reactome: R-HSA-179812;Reactome: R-HSA-1295596;Reactome: R-HSA-9028335;Reactome: R-HSA-6807004;Reactome: R-HSA-1257604;Reactome: R-HSA-388841;Reactome: R-HSA-1250196;Reactome: R-HSA-9034864;Reactome: R-HSA-182971;Reactome: R-HSA-1236382;Reactome: R-HSA-5654688;Reactome: R-HSA-1250347;Reactome: R-HSA-9664565;Reactome: R-HSA-354194;Reactome: R-HSA-5654695;Reactome: R-HSA-8875360;Reactome: R-HSA-180336;Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-180292;Reactome: R-HSA-8851805	"Tie2 Signaling";"FRS-mediated FGFR4 signaling";"MET activates PTPN11";"STAT5 Activation";"FRS-mediated FGFR3 signaling";"Signaling by FGFR3 point mutants in cancer";"Regulation of KIT signaling";"Insulin receptor signalling cascade";"CD28 dependent Vav1 pathway";"Signal regulatory protein family interactions";"RHO GTPases Activate WASPs and WAVEs";"Regulation of signaling by CBL";"PI-3K cascade:FGFR3";"DAP12 signaling";"SOS-mediated signalling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR2 signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"MET activates RAP1 and RAC1";"Interleukin-15 signaling";"Signal attenuation";"Activated NTRK2 signals through FRS2 and FRS3";"SHC-related events triggered by IGF1R";"Cargo recognition for clathrin-mediated endocytosis";"Erythropoietin activates RAS";"Negative regulation of FGFR3 signaling";"MET activates PI3K/AKT signaling";"Signaling by FGFR2 in disease";"RET signaling";"EGFR Transactivation by Gastrin";"PI3K Cascade";"Downstream signal transduction";"FCERI mediated MAPK activation";"Signaling by FGFR1 in disease";"MET receptor recycling";"Signaling by cytosolic FGFR1 fusion mutants";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Signaling by FGFR4 in disease";"Negative regulation of FGFR1 signaling";"GRB2 events in ERBB2 signaling";"Negative regulation of FGFR2 signaling";"Clathrin-mediated endocytosis";"Signaling by SCF-KIT";"FCERI mediated Ca+2 mobilization";"SHC-mediated cascade:FGFR3";"PI3K events in ERBB2 signaling";"Signaling by FGFR3 fusions in cancer";"Interleukin receptor SHC signaling";"Activated NTRK2 signals through RAS";"Regulation of actin dynamics for phagocytic cup formation";"Role of LAT2/NTAL/LAB on calcium mobilization";"SHC-mediated cascade:FGFR4";"Signalling to RAS";"SHC-mediated cascade:FGFR2";"Constitutive Signaling by EGFRvIII";"FLT3 Signaling";"Constitutive Signaling by Overexpressed ERBB2";"PI-3K cascade:FGFR4";"GRB2 events in EGFR signaling";"Spry regulation of FGF signaling";"Activated NTRK2 signals through PI3K";"Negative regulation of MET activity";"PIP3 activates AKT signaling";"Costimulation by the CD28 family";"SHC1 events in ERBB2 signaling";"Activated NTRK3 signals through RAS";"EGFR downregulation";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"SHC-mediated cascade:FGFR1";"SHC1 events in ERBB4 signaling";"Signaling by ERBB2 KD Mutants";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"PI-3K cascade:FGFR2";"InlB-mediated entry of Listeria monocytogenes into host cell";"SHC1 events in EGFR signaling";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"GAB1 signalosome";"MET activates RAS signaling"
XP_053960665.1	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
XP_053964587.1	13	KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-7721;MetaCyc: PWY-6859;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-7182;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-7709;MetaCyc: PWY-5123	"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Linalool biosynthesis I";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis"
XP_053965386.1	3	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-390471	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis"
XP_053953944.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053961630.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053965394.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053961848.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053954092.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053954665.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053949828.1	3	Reactome: R-HSA-5423646;Reactome: R-HSA-5579007;KEGG: 00220+3.5.1.14	"Aflatoxin activation and detoxification";"Defective ACY1 causes encephalopathy";"Arginine biosynthesis"
XP_053945292.1	8	Reactome: R-HSA-69166;Reactome: R-HSA-68952;Reactome: R-HSA-174411;Reactome: R-HSA-113501;Reactome: R-HSA-69091;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-174430	"Removal of the Flap Intermediate";"DNA replication initiation";"Polymerase switching on the C-strand of the telomere";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Polymerase switching";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Telomere C-strand synthesis initiation"
XP_053966803.1	4	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-1268020;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial protein import";"Mitochondrial translation termination"
XP_053960344.1	10	Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-3214847;Reactome: R-HSA-75953;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776	"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"HATs acetylate histones";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape"
XP_053956298.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1660662	"Neutrophil degranulation";"Glycosphingolipid metabolism"
XP_053958312.1	6	MetaCyc: PWY-7290;Reactome: R-HSA-913709;MetaCyc: PWY-7433;KEGG: 00512+2.4.1.122;KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632	"Escherichia coli serotype O86 O-antigen biosynthesis";"O-linked glycosylation of mucins";"Mucin core 1 and core 2 O-glycosylation";"Mucin type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)"
XP_053964704.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053952378.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053954656.1	2	Reactome: R-HSA-1483115;Reactome: R-HSA-1483152	"Hydrolysis of LPC";"Hydrolysis of LPE"
XP_053952994.1	15	Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-9018519;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-2173796;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-6807505;Reactome: R-HSA-167246;Reactome: R-HSA-176034;Reactome: R-HSA-112382;Reactome: R-HSA-167238	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Estrogen-dependent gene expression";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript";"Interactions of Tat with host cellular proteins";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation"
XP_053962660.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053962273.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053957197.1	4	Reactome: R-HSA-111465;Reactome: R-HSA-5689880;Reactome: R-HSA-176187;Reactome: R-HSA-5693607	"Apoptotic cleavage of cellular proteins";"Ub-specific processing proteases";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends"
XP_053961284.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053949767.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053949782.1	4	MetaCyc: PWY-801;KEGG: 00260+4.2.1.22;Reactome: R-HSA-1614603;KEGG: 00270+4.2.1.22	"Homocysteine and cysteine interconversion";"Glycine, serine and threonine metabolism";"Cysteine formation from homocysteine";"Cysteine and methionine metabolism"
XP_053965663.1	6	Reactome: R-HSA-1650814;Reactome: R-HSA-2022090;Reactome: R-HSA-3000171;Reactome: R-HSA-8948216;Reactome: R-HSA-8874081;Reactome: R-HSA-1442490	"Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures";"Non-integrin membrane-ECM interactions";"Collagen chain trimerization";"MET activates PTK2 signaling";"Collagen degradation"
XP_053965270.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_053963136.1	10	MetaCyc: PWY-6369;MetaCyc: PWY-6554;MetaCyc: PWY-6362;MetaCyc: PWY-6361;KEGG: 04070+2.7.1.158;MetaCyc: PWY-4661;KEGG: 00562+2.7.1.158;Reactome: R-HSA-1855167;Reactome: R-HSA-1855191;MetaCyc: PWY-6372	"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Inositol phosphate metabolism";"Synthesis of pyrophosphates in the cytosol";"Synthesis of IPs in the nucleus";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)"
XP_053964757.1	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053962518.1	5	Reactome: R-HSA-211945;Reactome: R-HSA-8937144;Reactome: R-HSA-211981;Reactome: R-HSA-1989781;Reactome: R-HSA-211976	"Phase I - Functionalization of compounds";"Aryl hydrocarbon receptor signalling";"Xenobiotics";"PPARA activates gene expression";"Endogenous sterols"
XP_053968579.1	6	Reactome: R-HSA-4411364;Reactome: R-HSA-3769402;Reactome: R-HSA-8951430;Reactome: R-HSA-4086398;Reactome: R-HSA-201722;Reactome: R-HSA-4641265	"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex";"RUNX3 regulates WNT signaling";"Ca2+ pathway";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes"
XP_053950659.1	2	Reactome: R-HSA-71336;KEGG: 00030+2.7.1.15	"Pentose phosphate pathway";"Pentose phosphate pathway"
XP_053950531.1	5	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-5620924;Reactome: R-HSA-1445148;Reactome: R-HSA-2132295	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Intraflagellar transport";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"MHC class II antigen presentation"
XP_053966554.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053962982.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950652.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053951999.1	2	Reactome: R-HSA-444821;Reactome: R-HSA-418555	"Relaxin receptors";"G alpha (s) signalling events"
XP_053966781.1	83	Reactome: R-HSA-912631;Reactome: R-HSA-5663213;Reactome: R-HSA-391160;Reactome: R-HSA-74751;Reactome: R-HSA-389359;Reactome: R-HSA-1433559;Reactome: R-HSA-5654710;Reactome: R-HSA-9645135;Reactome: R-HSA-8865999;Reactome: R-HSA-5654712;Reactome: R-HSA-210993;Reactome: R-HSA-8853338;Reactome: R-HSA-5654706;Reactome: R-HSA-983695;Reactome: R-HSA-8875555;Reactome: R-HSA-5654700;Reactome: R-HSA-5654693;Reactome: R-HSA-6811558;Reactome: R-HSA-112412;Reactome: R-HSA-8983432;Reactome: R-HSA-2424491;Reactome: R-HSA-109704;Reactome: R-HSA-2179392;Reactome: R-HSA-8853659;Reactome: R-HSA-8851907;Reactome: R-HSA-5655253;Reactome: R-HSA-9028731;Reactome: R-HSA-74749;Reactome: R-HSA-5654732;Reactome: R-HSA-8856825;Reactome: R-HSA-9027284;Reactome: R-HSA-2428933;Reactome: R-HSA-8875656;Reactome: R-HSA-5655302;Reactome: R-HSA-2219530;Reactome: R-HSA-512988;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-1839117;Reactome: R-HSA-186763;Reactome: R-HSA-2871796;Reactome: R-HSA-5654704;Reactome: R-HSA-2871809;Reactome: R-HSA-912526;Reactome: R-HSA-1963642;Reactome: R-HSA-8853334;Reactome: R-HSA-1963640;Reactome: R-HSA-5654726;Reactome: R-HSA-5655291;Reactome: R-HSA-1433557;Reactome: R-HSA-8856828;Reactome: R-HSA-5654727;Reactome: R-HSA-5637810;Reactome: R-HSA-5654699;Reactome: R-HSA-167044;Reactome: R-HSA-5654719;Reactome: R-HSA-2730905;Reactome: R-HSA-179812;Reactome: R-HSA-1295596;Reactome: R-HSA-5654720;Reactome: R-HSA-9634285;Reactome: R-HSA-9607240;Reactome: R-HSA-2029482;Reactome: R-HSA-9026519;Reactome: R-HSA-388841;Reactome: R-HSA-1257604;Reactome: R-HSA-1236382;Reactome: R-HSA-182971;Reactome: R-HSA-9034864;Reactome: R-HSA-1250196;Reactome: R-HSA-9028335;Reactome: R-HSA-6807004;Reactome: R-HSA-180336;Reactome: R-HSA-8851805;Reactome: R-HSA-5673001;Reactome: R-HSA-180292;Reactome: R-HSA-375165;Reactome: R-HSA-9664565;Reactome: R-HSA-1250347;Reactome: R-HSA-5654688;Reactome: R-HSA-8875360;Reactome: R-HSA-354194;Reactome: R-HSA-5654695	"Regulation of signaling by CBL";"RHO GTPases Activate WASPs and WAVEs";"Signal regulatory protein family interactions";"Insulin receptor signalling cascade";"CD28 dependent Vav1 pathway";"Regulation of KIT signaling";"PI-3K cascade:FGFR3";"STAT5 Activation";"MET activates PTPN11";"FRS-mediated FGFR4 signaling";"Tie2 Signaling";"Signaling by FGFR3 point mutants in cancer";"FRS-mediated FGFR3 signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"MET activates RAP1 and RAC1";"FRS-mediated FGFR2 signaling";"FRS-mediated FGFR1 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SOS-mediated signalling";"Interleukin-15 signaling";"DAP12 signaling";"PI3K Cascade";"EGFR Transactivation by Gastrin";"RET signaling";"MET activates PI3K/AKT signaling";"Signaling by FGFR2 in disease";"Activated NTRK2 signals through FRS2 and FRS3";"Signal attenuation";"Negative regulation of FGFR3 signaling";"Cargo recognition for clathrin-mediated endocytosis";"Erythropoietin activates RAS";"SHC-related events triggered by IGF1R";"MET receptor recycling";"Signaling by FGFR1 in disease";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"Signaling by cytosolic FGFR1 fusion mutants";"Downstream signal transduction";"FCERI mediated MAPK activation";"SHC-mediated cascade:FGFR3";"FCERI mediated Ca+2 mobilization";"Interleukin receptor SHC signaling";"PI3K events in ERBB2 signaling";"Signaling by FGFR3 fusions in cancer";"GRB2 events in ERBB2 signaling";"Negative regulation of FGFR1 signaling";"Signaling by FGFR4 in disease";"Signaling by SCF-KIT";"Clathrin-mediated endocytosis";"Negative regulation of FGFR2 signaling";"Constitutive Signaling by EGFRvIII";"SHC-mediated cascade:FGFR2";"Signalling to RAS";"SHC-mediated cascade:FGFR4";"Role of LAT2/NTAL/LAB on calcium mobilization";"GRB2 events in EGFR signaling";"Spry regulation of FGF signaling";"PI-3K cascade:FGFR4";"Constitutive Signaling by Overexpressed ERBB2";"FLT3 Signaling";"Regulation of actin dynamics for phagocytic cup formation";"Activated NTRK2 signals through RAS";"Costimulation by the CD28 family";"PIP3 activates AKT signaling";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"EGFR downregulation";"Activated NTRK3 signals through RAS";"SHC1 events in ERBB2 signaling";"Activated NTRK2 signals through PI3K";"Negative regulation of MET activity";"SHC1 events in EGFR signaling";"MET activates RAS signaling";"RAF/MAP kinase cascade";"GAB1 signalosome";"NCAM signaling for neurite out-growth";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB4 signaling";"SHC-mediated cascade:FGFR1";"InlB-mediated entry of Listeria monocytogenes into host cell";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"PI-3K cascade:FGFR2"
XP_053955461.1	5	Reactome: R-HSA-3214815;Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606	"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_053951992.1	2	Reactome: R-HSA-444821;Reactome: R-HSA-418555	"Relaxin receptors";"G alpha (s) signalling events"
XP_053948422.1	56	Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-450408;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-4608870;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-9604323	"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Asymmetric localization of PCP proteins";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Hedgehog 'on' state";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Negative regulation of NOTCH4 signaling"
XP_053946380.1	5	MetaCyc: PWY-5532;KEGG: 00240+2.4.2.3;Reactome: R-HSA-73621;Reactome: R-HSA-73614;KEGG: 00983+2.4.2.3	"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine metabolism";"Pyrimidine catabolism";"Pyrimidine salvage";"Drug metabolism - other enzymes"
XP_053965513.1	1	Reactome: R-HSA-198933	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
XP_053950701.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053956998.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053956636.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876	"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing"
XP_053950872.1	5	MetaCyc: PWY-8043;KEGG: 00270+6.3.2.3;KEGG: 00480+6.3.2.3;Reactome: R-HSA-174403;Reactome: R-HSA-5579006	"Ophthalmate biosynthesis";"Cysteine and methionine metabolism";"Glutathione metabolism";"Glutathione synthesis and recycling";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)"
XP_053962510.1	5	KEGG: 00010+4.1.1.32;KEGG: 00620+4.1.1.32;KEGG: 00020+4.1.1.32;Reactome: R-HSA-70263;MetaCyc: PWY-7383	"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)"
XP_053953920.1	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
XP_053945999.1	6	MetaCyc: PWY-6317;KEGG: 00052+2.7.7.12;Reactome: R-HSA-5609978;Reactome: R-HSA-70370;KEGG: 00520+2.7.7.12;MetaCyc: PWY-6527	"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Defective GALT can cause Galactosemia";"Galactose catabolism";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation"
XP_053964923.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_053958352.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053949820.1	3	Reactome: R-HSA-5579007;Reactome: R-HSA-5423646;KEGG: 00220+3.5.1.14	"Defective ACY1 causes encephalopathy";"Aflatoxin activation and detoxification";"Arginine biosynthesis"
XP_053953164.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053963726.1	6	KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I"
XP_053961840.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053949841.1	3	Reactome: R-HSA-1442490;Reactome: R-HSA-1474228;Reactome: R-HSA-1592389	"Collagen degradation";"Degradation of the extracellular matrix";"Activation of Matrix Metalloproteinases"
XP_053965677.1	2	Reactome: R-HSA-204174;Reactome: R-HSA-5362517	"Regulation of pyruvate dehydrogenase (PDH) complex";"Signaling by Retinoic Acid"
XP_053962289.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053952370.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053950612.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_053964717.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053947413.1	1	Reactome: R-HSA-5657655	"MGMT-mediated DNA damage reversal"
XP_053946438.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053961821.1	6	Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-176974	"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Unwinding of DNA"
XP_053964534.1	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
XP_053965887.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053967529.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053954686.1	7	MetaCyc: PWY-6545;MetaCyc: PWY-7198;MetaCyc: PWY-7185;MetaCyc: PWY-7184;KEGG: 00730+3.6.1.15;MetaCyc: PWY-7210;KEGG: 00230+3.6.1.15	"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"UTP and CTP dephosphorylation I";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Thiamine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Purine metabolism"
XP_053965869.1	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
XP_053946310.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_053950853.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053958432.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053966711.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053965644.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053951598.1	1	Reactome: R-HSA-419037	"NCAM1 interactions"
XP_053950445.1	13	Reactome: R-HSA-4420097;Reactome: R-HSA-5627117;Reactome: R-HSA-3928663;KEGG: 05163+2.7.11.1;Reactome: R-HSA-416572;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-3928662;KEGG: 04151+2.7.11.1	"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate ROCKs";"EPHA-mediated growth cone collapse";"Human cytomegalovirus infection";"Sema4D induced cell migration and growth-cone collapse";"Human immunodeficiency virus 1 infection";"Thermogenesis";"G alpha (12/13) signalling events";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"EPHB-mediated forward signaling";"PI3K-Akt signaling pathway"
XP_053950557.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053964007.1	5	Reactome: R-HSA-5610783;Reactome: R-HSA-5610787;Reactome: R-HSA-5610780;Reactome: R-HSA-5632684;Reactome: R-HSA-5610785	"Degradation of GLI2 by the proteasome";"Hedgehog 'off' state";"Degradation of GLI1 by the proteasome";"Hedgehog 'on' state";"GLI3 is processed to GLI3R by the proteasome"
XP_053964762.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053945935.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053954585.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053958461.1	182	Reactome: R-HSA-5654732;Reactome: R-HSA-4641263;Reactome: R-HSA-2565942;Reactome: R-HSA-2122948;Reactome: R-HSA-9613829;Reactome: R-HSA-9636383;Reactome: R-HSA-2173791;Reactome: R-HSA-977225;Reactome: R-HSA-174084;Reactome: R-HSA-156902;Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-5610785;Reactome: R-HSA-3322077;Reactome: R-HSA-4641258;Reactome: R-HSA-175474;Reactome: R-HSA-450302;Reactome: R-HSA-6807004;Reactome: R-HSA-182971;Reactome: R-HSA-8948747;Reactome: R-HSA-445989;Reactome: R-HSA-5687128;Reactome: R-HSA-1358803;Reactome: R-HSA-4608870;Reactome: R-HSA-8875360;Reactome: R-HSA-532668;Reactome: R-HSA-69017;Reactome: R-HSA-975163;Reactome: R-HSA-8849469;Reactome: R-HSA-450408;Reactome: R-HSA-8941858;Reactome: R-HSA-5654727;Reactome: R-HSA-6781823;Reactome: R-HSA-174154;Reactome: R-HSA-5689901;Reactome: R-HSA-5654726;Reactome: R-HSA-211733;Reactome: R-HSA-162588;Reactome: R-HSA-69541;Reactome: R-HSA-6781827;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-9033241;Reactome: R-HSA-5689877;Reactome: R-HSA-5658442;Reactome: R-HSA-450321;Reactome: R-HSA-975110;Reactome: R-HSA-5685942;Reactome: R-HSA-936964;Reactome: R-HSA-174184;Reactome: R-HSA-174490;Reactome: R-HSA-2559580;Reactome: R-HSA-6783310;Reactome: R-HSA-202424;Reactome: R-HSA-3769402;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-5689603;Reactome: R-HSA-5656169;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-5696397;Reactome: R-HSA-72706;Reactome: R-HSA-8951664;Reactome: R-HSA-2173788;Reactome: R-HSA-6791226;Reactome: R-HSA-8876493;Reactome: R-HSA-2173795;Reactome: R-HSA-180585;Reactome: R-HSA-156827;Reactome: R-HSA-6804756;Reactome: R-HSA-205043;Reactome: R-HSA-8866652;Reactome: R-HSA-6804757;Reactome: R-HSA-937039;Reactome: R-HSA-1253288;Reactome: R-HSA-9013973;Reactome: R-HSA-5684264;Reactome: R-HSA-72695;Reactome: R-HSA-9020702;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-400253;Reactome: R-HSA-195253;Reactome: R-HSA-168928;Reactome: R-HSA-9645460;Reactome: R-HSA-5696394;Reactome: R-HSA-975956;Reactome: R-HSA-5656121;Reactome: R-HSA-110314;Reactome: R-HSA-6782210;Reactome: R-HSA-9010553;Reactome: R-HSA-5689896;Reactome: R-HSA-2408557;Reactome: R-HSA-6804760;Reactome: R-HSA-936440;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-975957;Reactome: R-HSA-5654733;Reactome: R-HSA-5693565;Reactome: R-HSA-192823;Reactome: R-HSA-9604323;Reactome: R-HSA-209543;Reactome: R-HSA-912631;Reactome: R-HSA-9615710;Reactome: R-HSA-5205685;Reactome: R-HSA-8948751;Reactome: R-HSA-5693607;Reactome: R-HSA-5357905;Reactome: R-HSA-5696400;Reactome: R-HSA-5675482;Reactome: R-HSA-9014325;Reactome: R-HSA-382556;Reactome: R-HSA-5696395;Reactome: R-HSA-2173796;Reactome: R-HSA-1236382;Reactome: R-HSA-9633012;Reactome: R-HSA-5655862;Reactome: R-HSA-180534;Reactome: R-HSA-1169091;Reactome: R-HSA-5357956;Reactome: R-HSA-72649;Reactome: R-HSA-69481;Reactome: R-HSA-8939902;Reactome: R-HSA-5675221;Reactome: R-HSA-917729;Reactome: R-HSA-6782135;Reactome: R-HSA-72764;Reactome: R-HSA-9013507;Reactome: R-HSA-2559585;Reactome: R-HSA-201681;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-209560;Reactome: R-HSA-1295596;Reactome: R-HSA-937072;Reactome: R-HSA-72702;Reactome: R-HSA-2559582;Reactome: R-HSA-5668541;Reactome: R-HSA-8856825;Reactome: R-HSA-8939236;Reactome: R-HSA-3785653;Reactome: R-HSA-168638;Reactome: R-HSA-937042;Reactome: R-HSA-901032;Reactome: R-HSA-2672351;Reactome: R-HSA-2979096;Reactome: R-HSA-2122947;Reactome: R-HSA-2871837;Reactome: R-HSA-69231;Reactome: R-HSA-975144;Reactome: R-HSA-349425;Reactome: R-HSA-8863795;Reactome: R-HSA-174048;Reactome: R-HSA-5362768;Reactome: R-HSA-110312;Reactome: R-HSA-68949;Reactome: R-HSA-2691232;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-9637628;Reactome: R-HSA-174178;Reactome: R-HSA-3134975;Reactome: R-HSA-5610780;Reactome: R-HSA-72689;Reactome: R-HSA-179409;Reactome: R-HSA-9646399;Reactome: R-HSA-110320;Reactome: R-HSA-5610783;Reactome: R-HSA-937041;Reactome: R-HSA-1799339;Reactome: R-HSA-68827;Reactome: R-HSA-8856828;Reactome: R-HSA-1169408;Reactome: R-HSA-8866654;Reactome: R-HSA-187577;Reactome: R-HSA-983168;Reactome: R-HSA-917937;Reactome: R-HSA-168927	"Negative regulation of FGFR3 signaling";"Regulation of FZD by ubiquitination";"Regulation of PLK1 Activity at G2/M Transition";"Activated NOTCH1 Transmits Signal to the Nucleus";"Chaperone Mediated Autophagy";"Prevention of phagosomal-lysosomal fusion";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Amyloid fiber formation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Peptide chain elongation";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"GLI3 is processed to GLI3R by the proteasome";"Glycogen synthesis";"Degradation of DVL";"Assembly Of The HIV Virion";"activated TAK1 mediates p38 MAPK activation";"Negative regulation of MET activity";"EGFR downregulation";"Regulation of PTEN localization";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"MAPK6/MAPK4 signaling";"Downregulation of ERBB2:ERBB3 signaling";"Asymmetric localization of PCP proteins";"InlB-mediated entry of Listeria monocytogenes into host cell";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"CDK-mediated phosphorylation and removal of Cdc6";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RUNX3 expression and activity";"Negative regulation of FGFR2 signaling";"Formation of TC-NER Pre-Incision Complex";"APC/C:Cdc20 mediated degradation of Securin";"Metalloprotease DUBs";"Negative regulation of FGFR1 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Budding and maturation of HIV virion";"Stabilization of p53";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Peroxisomal protein import";"Josephin domain DUBs";"Regulation of RAS by GAPs";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"HDR through Homologous Recombination (HRR)";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Membrane binding and targetting of GAG proteins";"Oxidative Stress Induced Senescence";"Fanconi Anemia Pathway";"Downstream TCR signaling";"Deactivation of the beta-catenin transactivating complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"UCH proteinases";"Termination of translesion DNA synthesis";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Neddylation";"Downregulation of TGF-beta receptor signaling";"Major pathway of rRNA processing in the nucleolus and cytosol";"InlA-mediated entry of Listeria monocytogenes into host cells";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Vif-mediated degradation of APOBEC3G";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of TP53 Activity through Phosphorylation";"NRIF signals cell death from the nucleus";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Regulation of TP53 Degradation";"IRAK1 recruits IKK complex";"Downregulation of ERBB4 signaling";"TICAM1-dependent activation of IRF3/IRF7";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Formation of the ternary complex, and subsequently, the 43S complex";"Interleukin-1 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"Circadian Clock";"Degradation of beta-catenin by the destruction complex";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Alpha-protein kinase 1 signaling pathway";"DNA Damage Recognition in GG-NER";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Translesion synthesis by POLI";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Regulation of expression of SLITs and ROBOs";"Ovarian tumor domain proteases";"Selenocysteine synthesis";"Regulation of TP53 Activity through Methylation";"Negative regulators of DDX58/IFIH1 signaling";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Negative regulation of FGFR4 signaling";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Viral mRNA Translation";"Negative regulation of NOTCH4 signaling";"p75NTR recruits signalling complexes";"Regulation of signaling by CBL";"Late endosomal microautophagy";"Pink/Parkin Mediated Mitophagy";"Regulation of PTEN stability and activity";"Processing of DNA double-strand break ends";"Regulation of TNFR1 signaling";"Dual Incision in GG-NER";"Regulation of necroptotic cell death";"TICAM1,TRAF6-dependent induction of TAK1 complex";"ABC-family proteins mediated transport";"Formation of Incision Complex in GG-NER";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translesion synthesis by POLK";"Vpu mediated degradation of CD4";"Activation of NF-kappaB in B cells";"TNFR1-induced NFkappaB signaling pathway";"Translation initiation complex formation";"G2/M Checkpoints";"Regulation of RUNX2 expression and activity";"Negative regulation of MAPK pathway";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Dual incision in TC-NER";"Eukaryotic Translation Termination";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Oncogene Induced Senescence";"TCF dependent signaling in response to WNT";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"NF-kB is activated and signals survival";"Spry regulation of FGF signaling";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Ribosomal scanning and start codon recognition";"Senescence-Associated Secretory Phenotype (SASP)";"TNFR2 non-canonical NF-kB pathway";"Cargo recognition for clathrin-mediated endocytosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Myoclonic epilepsy of Lafora";"NOD1/2 Signaling Pathway";"IRAK2 mediated activation of TAK1 complex";"ER Quality Control Compartment (ERQC)";"Stimuli-sensing channels";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH1 Intracellular Domain Regulates Transcription";"FCERI mediated NF-kB activation";"Cyclin D associated events in G1";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Autodegradation of the E3 ubiquitin ligase COP1";"Downregulation of ERBB2 signaling";"APC/C:Cdc20 mediated degradation of Cyclin B";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Translesion synthesis by REV1";"Orc1 removal from chromatin";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"Degradation of AXIN";"Hedgehog ligand biogenesis";"Modulation by Mtb of host immune system";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of innate immune responses to cytosolic DNA";"Degradation of GLI1 by the proteasome";"Formation of a pool of free 40S subunits";"APC-Cdc20 mediated degradation of Nek2A";"Aggrephagy";"Translesion Synthesis by POLH";"Degradation of GLI2 by the proteasome";"IKK complex recruitment mediated by RIP1";"SRP-dependent cotranslational protein targeting to membrane";"CDT1 association with the CDC6:ORC:origin complex";"Clathrin-mediated endocytosis";"ISG15 antiviral mechanism";"E3 ubiquitin ligases ubiquitinate target proteins";"SCF(Skp2)-mediated degradation of p27/p21";"Antigen processing: Ubiquitination & Proteasome degradation";"Iron uptake and transport";"TICAM1, RIP1-mediated IKK complex recruitment"
XP_053947797.1	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
XP_053962952.1	3	KEGG: 00561+3.1.1.23;Reactome: R-HSA-426048;MetaCyc: PWY-7420	"Glycerolipid metabolism";"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)"
XP_053951429.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053948999.1	14	MetaCyc: PWY-2201;KEGG: 00260+2.1.2.1;KEGG: 00630+2.1.2.1;KEGG: 00460+2.1.2.1;MetaCyc: PWY-1622;MetaCyc: PWY-3841;KEGG: 00680+2.1.2.1;MetaCyc: PWY-3661-1;MetaCyc: PWY-5497;MetaCyc: PWY-2161;MetaCyc: PWY-3661;Reactome: R-HSA-196757;MetaCyc: PWY-181;KEGG: 00670+2.1.2.1	"Folate transformations I";"Glycine, serine and threonine metabolism";"Glyoxylate and dicarboxylate metabolism";"Cyanoamino acid metabolism";"Formaldehyde assimilation I (serine pathway)";"Folate transformations II (plants)";"Methane metabolism";"Glycine betaine degradation II (mammalian)";"Purine nucleobases degradation II (anaerobic)";"Folate polyglutamylation";"Glycine betaine degradation I";"Metabolism of folate and pterines";"Photorespiration ";"One carbon pool by folate"
XP_053958776.1	3	KEGG: 00310+2.1.1.60;Reactome: R-HSA-2514859;Reactome: R-HSA-8876725	"Lysine degradation";"Inactivation, recovery and regulation of the phototransduction cascade";"Protein methylation"
XP_053962038.1	6	Reactome: R-HSA-418597;Reactome: R-HSA-76005;Reactome: R-HSA-5099900;Reactome: R-HSA-416993;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114516	"G alpha (z) signalling events";"Response to elevated platelet cytosolic Ca2+";"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors";"Phosphatidylinositol signaling system";"Disinhibition of SNARE formation"
XP_053966643.1	2	MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21	"Mitochondrial L-carnitine shuttle";"Fatty acid degradation"
XP_053966609.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_053967143.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_053948992.1	6	MetaCyc: PWY-6368;Reactome: R-HSA-1660516;Reactome: R-HSA-1660499;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.66;KEGG: 00562+3.1.3.66	"3-phosphoinositide degradation";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the plasma membrane";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism"
XP_053951935.1	9	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-198323;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"AKT phosphorylates targets in the cytosol";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"Relaxin signaling pathway"
XP_053951422.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053966602.1	4	MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48	"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism";"Pyrimidine salvage";"Drug metabolism - other enzymes"
XP_053959830.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053958225.1	11	KEGG: 00561+3.1.3.4;MetaCyc: PWY-8052;MetaCyc: PWY-8055;MetaCyc: PWY-8053;MetaCyc: PWY-8051;Reactome: R-HSA-2029485;KEGG: 00565+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;MetaCyc: PWY-6453;KEGG: 00564+3.1.3.4	"Glycerolipid metabolism";"2-arachidonoylglycerol biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"Anandamide biosynthesis I";"Role of phospholipids in phagocytosis";"Ether lipid metabolism";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism"
XP_053953143.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-2173788	"UCH proteinases";"Downregulation of TGF-beta receptor signaling"
XP_053964140.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_053954474.1	8	KEGG: 00514+2.4.1.109;Reactome: R-HSA-5083629;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922;Reactome: R-HSA-5173105;MetaCyc: PWY-7979;Reactome: R-HSA-5083633	"Other types of O-glycan biosynthesis";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"O-linked glycosylation";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1"
XP_053950517.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053945176.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053950968.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053966475.1	7	MetaCyc: PWY-6737;MetaCyc: PWY-6724;KEGG: 00500+2.4.1.25;MetaCyc: PWY-7238;Reactome: R-HSA-6798695;Reactome: R-HSA-70221;MetaCyc: PWY-5941	"Starch degradation V";"Starch degradation II";"Starch and sucrose metabolism";"Sucrose biosynthesis II";"Neutrophil degranulation";"Glycogen breakdown (glycogenolysis)";"Glycogen degradation II"
XP_053945235.1	4	Reactome: R-HSA-2214320;Reactome: R-HSA-1474228;Reactome: R-HSA-2243919;Reactome: R-HSA-1650814	"Anchoring fibril formation";"Degradation of the extracellular matrix";"Crosslinking of collagen fibrils";"Collagen biosynthesis and modifying enzymes"
XP_053945590.1	8	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Signaling by Hippo";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053955319.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053951590.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053959173.1	19	KEGG: 00630+1.1.1.37;MetaCyc: PWY-6969;MetaCyc: PWY-5392;KEGG: 00720+1.1.1.37;MetaCyc: PWY-1622;KEGG: 00680+1.1.1.37;MetaCyc: PWY-7383;MetaCyc: PWY-5690;KEGG: 00020+1.1.1.37;MetaCyc: PWY-5913;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-7115;KEGG: 00620+1.1.1.37;KEGG: 00270+1.1.1.37;KEGG: 00710+1.1.1.37;MetaCyc: PWY-561;MetaCyc: PWY-8086;Reactome: R-HSA-70263	"Glyoxylate and dicarboxylate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"TCA cycle II (plants and fungi)";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Pyruvate metabolism";"Cysteine and methionine metabolism";"Carbon fixation in photosynthetic organisms";"Superpathway of glyoxylate cycle and fatty acid degradation";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis"
XP_053956015.1	11	Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-5610787;Reactome: R-HSA-164378	"G alpha (s) signalling events";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Glucagon signaling in metabolic regulation";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"G alpha (i) signalling events";"Hedgehog 'off' state";"PKA activation in glucagon signalling"
XP_053951235.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_053948292.1	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
XP_053960377.1	42	Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-3214858;Reactome: R-HSA-73728;Reactome: R-HSA-3214815;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-5334118;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-9018519;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-2299718;Reactome: R-HSA-3214842;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-427413	"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RMTs methylate histone arginines";"RNA Polymerase I Promoter Opening";"HDACs deacetylate histones";"Meiotic synapsis";"Packaging Of Telomere Ends";"DNA methylation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Estrogen-dependent gene expression";"Meiotic recombination";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Condensation of Prophase Chromosomes";"HDMs demethylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"NoRC negatively regulates rRNA expression"
XP_053961626.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053958737.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053960807.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053957144.1	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
XP_053963261.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053958001.1	3	Reactome: R-HSA-983168;Reactome: R-HSA-390471;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Association of TriC/CCT with target proteins during biosynthesis";"Neddylation"
XP_053963050.1	40	MetaCyc: PWY-6883;KEGG: 00592+4.2.1.17;MetaCyc: PWY-6863;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6945;MetaCyc: PWY-7094;MetaCyc: PWY-7654;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-7606;MetaCyc: PWY-6946;MetaCyc: PWY-7007;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00410+4.2.1.17;MetaCyc: PWY-7779;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-6944;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-7726;MetaCyc: PWY-7216;MetaCyc: PWY-5138;KEGG: 00623+1.1.1.35;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7778;MetaCyc: PWY-5109;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-5136;KEGG: 00360+4.2.1.17;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;MetaCyc: PWY-5789;MetaCyc: PWY-7401;MetaCyc: PWY-6583;MetaCyc: PWY-5177;MetaCyc: PWY-6435;KEGG: 00930+4.2.1.17+1.1.1.35	"Pyruvate fermentation to butanol II (engineered)";"alpha-Linolenic acid metabolism";"Pyruvate fermentation to hexanol (engineered)";"Limonene and pinene degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Fatty acid salvage";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Benzoate degradation";"Propanoate metabolism";"Lysine degradation";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Methyl ketone biosynthesis (engineered)";"Butanoate metabolism";"beta-Alanine metabolism";"Methyl tert-butyl ether degradation";"Carbon fixation pathways in prokaryotes";"Androstenedione degradation";"Tryptophan metabolism";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Toluene degradation";"Aminobenzoate degradation";"2-methylpropene degradation";"Fermentation to 2-methylbutanoate";"Geraniol degradation";"Spodoptera littoralis pheromone biosynthesis";"Fatty acid degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"Phenylalanine metabolism";"Valine, leucine and isoleucine degradation";"Fatty acid elongation";"Benzoyl-coa degradation I (aerobic)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Pyruvate fermentation to butanol I";"Glutaryl-coa degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Caprolactam degradation"
XP_053954053.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-5205685	"Mitochondrial protein import";"Pink/Parkin Mediated Mitophagy"
XP_053965592.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053960486.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053945868.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-425561	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Sodium/Calcium exchangers"
XP_053947366.1	2	Reactome: R-HSA-189451;KEGG: 00860+4.99.1.1	"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_053956862.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053946207.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053959448.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053955602.1	57	Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-9604323;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-4641257;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-382556;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-174178;Reactome: R-HSA-4608870;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-6798695	"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Hedgehog 'on' state";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"Negative regulation of NOTCH4 signaling";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Degradation of AXIN";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Downstream TCR signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"ABC-family proteins mediated transport";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Asymmetric localization of PCP proteins";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Neutrophil degranulation"
XP_053963018.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053951727.1	3	Reactome: R-HSA-6785470;Reactome: R-HSA-8868766;Reactome: R-HSA-6784531	"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA processing in the nucleus"
XP_053947499.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway"
XP_053964467.1	3	Reactome: R-HSA-191859;Reactome: R-HSA-6804760;Reactome: R-HSA-3214858	"snRNP Assembly";"Regulation of TP53 Activity through Methylation";"RMTs methylate histone arginines"
XP_053945727.1	14	MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7619	"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis"
XP_053969623.1	2	Reactome: R-HSA-6787450;Reactome: R-HSA-6782315	"tRNA modification in the mitochondrion";"tRNA modification in the nucleus and cytosol"
XP_053965428.1	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
XP_053959256.1	22	Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-6811558;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716	"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Beta-catenin phosphorylation cascade";"RAF activation";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin"
XP_053952947.1	7	MetaCyc: PWY-6122;MetaCyc: PWY-6121;Reactome: R-HSA-73817;MetaCyc: PWY-6277;KEGG: 00250+2.4.2.14;MetaCyc: PWY-7282;KEGG: 00230+2.4.2.14	"5-aminoimidazole ribonucleotide biosynthesis II";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Alanine, aspartate and glutamate metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Purine metabolism"
XP_053950693.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434;Reactome: R-HSA-6798695	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation"
XP_053959916.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053962191.1	11	MetaCyc: PWY-6606;MetaCyc: PWY-7821;KEGG: 00240+3.1.3.5;MetaCyc: PWY-6596;KEGG: 00760+3.1.3.5;MetaCyc: PWY-5695;MetaCyc: PWY-5381;MetaCyc: PWY-6608;MetaCyc: PWY-7185;KEGG: 00230+3.1.3.5;MetaCyc: PWY-6607	"Guanosine nucleotides degradation II";"Tunicamycin biosynthesis";"Pyrimidine metabolism";"Adenosine nucleotides degradation I";"Nicotinate and nicotinamide metabolism";"Inosine 5'-phosphate degradation";"Pyridine nucleotide cycling (plants)";"Guanosine nucleotides degradation III";"UTP and CTP dephosphorylation I";"Purine metabolism";"Guanosine nucleotides degradation I"
XP_053952621.1	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
XP_053969750.1	2	Reactome: R-HSA-1237112;KEGG: 00270+3.1.3.77	"Methionine salvage pathway";"Cysteine and methionine metabolism"
XP_053963010.1	13	Reactome: R-HSA-6798695;Reactome: R-HSA-8876725;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346;Reactome: R-HSA-3371511;Reactome: R-HSA-9646399;Reactome: R-HSA-5678895;Reactome: R-HSA-110320;Reactome: R-HSA-5689877;Reactome: R-HSA-532668;Reactome: R-HSA-5689896;Reactome: R-HSA-382556;Reactome: R-HSA-8866654	"Neutrophil degranulation";"Protein methylation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis";"HSF1 activation";"Aggrephagy";"Defective CFTR causes cystic fibrosis";"Translesion Synthesis by POLH";"Josephin domain DUBs";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Ovarian tumor domain proteases";"ABC-family proteins mediated transport";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_053960336.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053958554.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053961350.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053945213.1	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
XP_053962423.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_053957239.1	1	Reactome: R-HSA-71288	"Creatine metabolism"
XP_053946907.1	40	Reactome: R-HSA-5578749;Reactome: R-HSA-167172;Reactome: R-HSA-72203;Reactome: R-HSA-73779;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167161;Reactome: R-HSA-5601884;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-203927;Reactome: R-HSA-6781823;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-167287;Reactome: R-HSA-6782135;Reactome: R-HSA-167162;Reactome: R-HSA-6781827;Reactome: R-HSA-167160;Reactome: R-HSA-77075;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-6803529;Reactome: R-HSA-167242;Reactome: R-HSA-168325;Reactome: R-HSA-6807505;Reactome: R-HSA-167246;Reactome: R-HSA-8851708;Reactome: R-HSA-9018519;Reactome: R-HSA-6782210;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-72165;Reactome: R-HSA-5617472;Reactome: R-HSA-75953	"Transcriptional regulation by small RNAs";"Transcription of the HIV genome";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"HIV Transcription Initiation";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase II Promoter Escape";"mRNA Capping";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"MicroRNA (miRNA) biogenesis";"Formation of TC-NER Pre-Incision Complex";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV elongation arrest and recovery";"Dual incision in TC-NER";"RNA Polymerase II HIV Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"FGFR2 alternative splicing";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Viral Messenger RNA Synthesis";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript";"Signaling by FGFR2 IIIa TM";"Estrogen-dependent gene expression";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"mRNA Splicing - Minor Pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase II Transcription Initiation"
XP_053947541.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_053969718.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_053959965.1	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"Intra-Golgi traffic"
XP_053963144.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053968298.1	12	KEGG: 00030+4.1.2.13;KEGG: 00680+4.1.2.13;Reactome: R-HSA-70171;KEGG: 00010+4.1.2.13;MetaCyc: PWY-1042;MetaCyc: PWY-7385;Reactome: R-HSA-70263;MetaCyc: PWY-5484;KEGG: 00710+4.1.2.13;MetaCyc: PWY-1861;KEGG: 00051+4.1.2.13;MetaCyc: PWY-6142	"Pentose phosphate pathway";"Methane metabolism";"Glycolysis";"Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Fructose and mannose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
XP_053948979.1	6	Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257	"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion"
XP_053946954.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053951137.1	13	KEGG: 00720+4.2.1.2;MetaCyc: PWY-5690;MetaCyc: PWY-5392;MetaCyc: PWY-6969;KEGG: 00620+4.2.1.2;MetaCyc: PWY-561;MetaCyc: PWY-8086;MetaCyc: PWY-7254;MetaCyc: PWY-7384;KEGG: 00020+4.2.1.2;MetaCyc: PWY-5913;MetaCyc: PWY-6728;Reactome: R-HSA-71403	"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate metabolism";"Superpathway of glyoxylate cycle and fatty acid degradation";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"TCA cycle VII (acetate-producers)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)"
XP_053970049.1	4	KEGG: 00561+2.7.1.30;Reactome: R-HSA-5661270;MetaCyc: PWY-4261;KEGG: 00040+2.7.1.17	"Glycerolipid metabolism";"Formation of xylulose-5-phosphate";"Glycerol degradation I";"Pentose and glucuronate interconversions"
XP_053948972.1	3	KEGG: 00790+1.1.1.153;Reactome: R-HSA-1474151;Reactome: R-HSA-203615	"Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"eNOS activation"
XP_053946214.1	2	Reactome: R-HSA-5223345;Reactome: R-HSA-425393	"Miscellaneous transport and binding events";"Transport of inorganic cations/anions and amino acids/oligopeptides"
XP_053945860.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Sodium/Calcium exchangers";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
XP_053965298.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053951979.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053963177.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053956857.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053955849.1	3	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109	"Glycerol degradation I";"Glycerolipid metabolism";"Triglyceride biosynthesis"
XP_053958034.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053949431.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053955507.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053952800.1	1	Reactome: R-HSA-391908	"Prostanoid ligand receptors"
XP_053947222.1	8	Reactome: R-HSA-6798695;Reactome: R-HSA-74217;MetaCyc: PWY-6611;MetaCyc: PWY-6609;KEGG: 00230+3.5.4.4;MetaCyc: PWY-7179-1;Reactome: R-HSA-5683826;MetaCyc: PWY-7179	"Neutrophil degranulation";"Purine salvage";"Adenine and adenosine salvage V";"Adenine and adenosine salvage III";"Purine metabolism";"Purine deoxyribonucleosides degradation II";"Surfactant metabolism";"Purine deoxyribonucleosides degradation I"
XP_053963995.1	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
XP_053945283.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053968015.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport"
XP_053949396.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053951111.1	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
XP_053955664.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053953906.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_053946023.1	10	KEGG: 00561+2.3.1.15;MetaCyc: PWY-8051;MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;KEGG: 00564+2.3.1.15;MetaCyc: PWY-6453	"Glycerolipid metabolism";"Anandamide biosynthesis I";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis"
XP_053955796.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_053945979.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053964395.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053954224.1	2	Reactome: R-HSA-427413;Reactome: R-HSA-3214847	"NoRC negatively regulates rRNA expression";"HATs acetylate histones"
XP_053954749.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053954703.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-4090294	"Nuclear Receptor transcription pathway";"SUMOylation of intracellular receptors"
XP_053959286.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053962993.1	7	KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1660499;Reactome: R-HSA-8856828;Reactome: R-HSA-1855204	"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the plasma membrane";"Clathrin-mediated endocytosis";"Synthesis of IP3 and IP4 in the cytosol"
XP_053960647.1	9	Reactome: R-HSA-2426168;Reactome: R-HSA-400253;Reactome: R-HSA-1368108;Reactome: R-HSA-400206;Reactome: R-HSA-5617472;Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082	"Activation of gene expression by SREBF (SREBP)";"Circadian Clock";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Regulation of lipid metabolism by PPARalpha";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression"
XP_053958475.1	6	Reactome: R-HSA-8948751;Reactome: R-HSA-2173788;Reactome: R-HSA-8939902;MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-8863795	"Regulation of PTEN stability and activity";"Downregulation of TGF-beta receptor signaling";"Regulation of RUNX2 expression and activity";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Downregulation of ERBB2 signaling"
XP_053964452.1	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
XP_053958751.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_053966225.1	10	KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00531+3.2.1.23;Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2160916;KEGG: 00052+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2206292	"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Glycosaminoglycan degradation";"HS-GAG degradation";"Neutrophil degranulation";"Hyaluronan uptake and degradation";"Galactose metabolism";"Sphingolipid metabolism";"Other glycan degradation";"MPS VII - Sly syndrome"
XP_053948578.1	2	Reactome: R-HSA-975957;Reactome: R-HSA-9010553	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
XP_053960921.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-9020702	"Neutrophil degranulation";"Interleukin-1 signaling"
XP_053957530.1	9	MetaCyc: PWY-6351;Reactome: R-HSA-1855204;MetaCyc: PWY-8052;MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11;Reactome: R-HSA-416476;MetaCyc: PWY-6367;Reactome: R-HSA-112043	"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"2-arachidonoylglycerol biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"G alpha (q) signalling events";"D-myo-inositol-5-phosphate metabolism";"PLC beta mediated events"
XP_053949793.1	4	Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2470946	"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin"
XP_053965697.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053966382.1	1	MetaCyc: PWY-7533	"Gliotoxin biosynthesis"
XP_053966389.1	9	MetaCyc: PWY-6142;KEGG: 00720+6.4.1.1;KEGG: 00620+6.4.1.1;MetaCyc: PWY-6146;Reactome: R-HSA-3371599;KEGG: 00020+6.4.1.1;Reactome: R-HSA-196780;Reactome: R-HSA-70263;MetaCyc: PWY-8086	"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Carbon fixation pathways in prokaryotes";"Pyruvate metabolism";"Methanobacterium thermoautotrophicum biosynthetic metabolism";"Defective HLCS causes multiple carboxylase deficiency";"Citrate cycle (TCA cycle)";"Biotin transport and metabolism";"Gluconeogenesis";"(S)-lactate fermentation to propanoate, acetate and hydrogen"
XP_053955393.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053967206.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053960940.1	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
XP_053948213.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_053960884.1	3	KEGG: 00860+1.3.3.3;Reactome: R-HSA-189451;MetaCyc: PWY-7159	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"
XP_053956513.1	3	KEGG: 00480+4.3.2.9;Reactome: R-HSA-174403;MetaCyc: PWY-4041	"Glutathione metabolism";"Glutathione synthesis and recycling";"Gamma-glutamyl cycle"
XP_053951279.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_053945983.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053947435.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053956817.1	1	KEGG: 00230+3.6.1.29	"Purine metabolism"
XP_053954837.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053954079.1	7	KEGG: 00480+2.5.1.22;Reactome: R-HSA-351202;KEGG: 00480+2.5.1.16;KEGG: 00270+2.5.1.22;KEGG: 00270+2.5.1.16;KEGG: 00330+2.5.1.22;KEGG: 00330+2.5.1.16	"Glutathione metabolism";"Metabolism of polyamines";"Glutathione metabolism";"Cysteine and methionine metabolism";"Cysteine and methionine metabolism";"Arginine and proline metabolism";"Arginine and proline metabolism"
XP_053958584.1	3	KEGG: 00643+1.13.11.5;KEGG: 00350+1.13.11.5;Reactome: R-HSA-8963684	"Styrene degradation";"Tyrosine metabolism";"Tyrosine catabolism"
XP_053962156.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053955514.1	8	Reactome: R-HSA-180024;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-983231;Reactome: R-HSA-381676	"DARPP-32 events";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"Factors involved in megakaryocyte development and platelet production";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"
XP_053966925.1	2	Reactome: R-HSA-426117;Reactome: R-HSA-5619039	"Cation-coupled Chloride cotransporters";"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)"
XP_053966432.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053957080.1	9	Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-6804756	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Regulation of TP53 Activity through Phosphorylation"
XP_053954881.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053952029.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053963088.1	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
XP_053960240.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-9018519	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression"
XP_053952022.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053956970.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_053954240.1	4	KEGG: 00785+2.8.1.8;MetaCyc: PWY-7382;MetaCyc: PWY-6987;Reactome: R-HSA-389661	"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoate biosynthesis and incorporation III (Bacillus)";"Glyoxylate metabolism and glycine degradation"
XP_053960881.1	5	KEGG: 00281+4.1.3.4;KEGG: 00072+4.1.3.4;MetaCyc: PWY-5074;KEGG: 00280+4.1.3.4;KEGG: 00650+4.1.3.4	"Geraniol degradation";"Synthesis and degradation of ketone bodies";"Mevalonate degradation";"Valine, leucine and isoleucine degradation";"Butanoate metabolism"
XP_053951040.1	8	Reactome: R-HSA-5620912;Reactome: R-HSA-5689880;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"Ub-specific processing proteases";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes"
XP_053945040.1	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
XP_053969550.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_053958170.1	9	KEGG: 00511+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7883;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902	"Other glycan degradation";"Various types of N-glycan biosynthesis";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)"
XP_053954221.1	2	Reactome: R-HSA-3214847;Reactome: R-HSA-427413	"HATs acetylate histones";"NoRC negatively regulates rRNA expression"
XP_053960924.1	7	Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-5626467	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"RHO GTPases activate IQGAPs"
XP_053946996.1	2	Reactome: R-HSA-8862803;Reactome: R-HSA-69273	"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Cyclin A/B1/B2 associated events during G2/M transition"
XP_053956391.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053955661.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053958596.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-6803157	"Neutrophil degranulation";"Antimicrobial peptides"
XP_053951114.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053967321.1	4	Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2470946	"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin"
XP_053961135.1	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
XP_053954948.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_053962245.1	5	Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-69205;Reactome: R-HSA-68949;Reactome: R-HSA-68827	"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"G1/S-Specific Transcription";"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex"
XP_053947873.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053958031.1	1	Reactome: R-HSA-2428928	"IRS-related events triggered by IGF1R"
XP_053960079.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053956436.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053960837.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053967340.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053952152.1	5	MetaCyc: PWY-7426;KEGG: 00533+2.4.1.68;Reactome: R-HSA-975578;KEGG: 00513+2.4.1.68;KEGG: 00510+2.4.1.68	"Complex N-linked glycan biosynthesis (vertebrates)";"Glycosaminoglycan biosynthesis - keratan sulfate";"Reactions specific to the complex N-glycan synthesis pathway";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
XP_053953348.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053963909.1	2	Reactome: R-HSA-191859;Reactome: R-HSA-6807505	"snRNP Assembly";"RNA polymerase II transcribes snRNA genes"
XP_053959826.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053954940.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053962460.1	13	MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-7182;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7709;MetaCyc: PWY-5123;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-7721;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-6859	"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"Linalool biosynthesis I";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Methyl phomopsenoate biosynthesis";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"All-trans-farnesol biosynthesis"
XP_053965463.1	5	MetaCyc: PWY-7269;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_053946981.1	4	Reactome: R-HSA-71240;Reactome: R-HSA-210991;Reactome: R-HSA-352230;Reactome: R-HSA-5660862	"Tryptophan catabolism";"Basigin interactions";"Amino acid transport across the plasma membrane";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)"
XP_053958714.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053950452.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_053946296.1	2	Reactome: R-HSA-5682910;Reactome: R-HSA-5250971	"LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)"
XP_053959294.1	22	Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-6811558;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5358751;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-196299;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5673000;Reactome: R-HSA-2500257	"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"RAF activation";"Resolution of Sister Chromatid Cohesion"
XP_053950805.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053955004.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053960703.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053951048.1	3	Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369	"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis"
XP_053950395.1	1	Reactome: R-HSA-211897	"Cytochrome P450 - arranged by substrate type"
XP_053951770.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053960083.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053966464.1	7	Reactome: R-HSA-5083629;Reactome: R-HSA-3000178;Reactome: R-HSA-9010553;Reactome: R-HSA-5173105;Reactome: R-HSA-5083633;Reactome: R-HSA-3000171;Reactome: R-HSA-5083628	"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"ECM proteoglycans";"Regulation of expression of SLITs and ROBOs";"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Non-integrin membrane-ECM interactions";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3"
XP_053957202.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053952971.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_053954465.1	1	Reactome: R-HSA-2465910	"MASTL Facilitates Mitotic Progression"
XP_053964899.1	6	Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68867	"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state";"Unwinding of DNA";"Assembly of the pre-replicative complex"
XP_053961725.1	13	Reactome: R-HSA-3000178;Reactome: R-HSA-1474244;Reactome: R-HSA-2022090;Reactome: R-HSA-419037;Reactome: R-HSA-1442490;Reactome: R-HSA-3000157;Reactome: R-HSA-1650814;Reactome: R-HSA-8948216;Reactome: R-HSA-3000171;Reactome: R-HSA-2243919;Reactome: R-HSA-216083;Reactome: R-HSA-2214320;Reactome: R-HSA-186797	"ECM proteoglycans";"Extracellular matrix organization";"Assembly of collagen fibrils and other multimeric structures";"NCAM1 interactions";"Collagen degradation";"Laminin interactions";"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization";"Non-integrin membrane-ECM interactions";"Crosslinking of collagen fibrils";"Integrin cell surface interactions";"Anchoring fibril formation";"Signaling by PDGF"
XP_053969289.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053964746.1	3	Reactome: R-HSA-6806664;MetaCyc: PWY-7999;KEGG: 00130+1.17.4.4	"Metabolism of vitamin K";"Vitamin K-epoxide cycle";"Ubiquinone and other terpenoid-quinone biosynthesis"
XP_053947130.1	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
XP_053956042.1	16	Reactome: R-HSA-1963640;Reactome: R-HSA-8847993;Reactome: R-HSA-1250342;Reactome: R-HSA-1227986;Reactome: R-HSA-1257604;Reactome: R-HSA-1250196;Reactome: R-HSA-1963642;Reactome: R-HSA-9664565;Reactome: R-HSA-1250347;Reactome: R-HSA-6785631;Reactome: R-HSA-1236394;Reactome: R-HSA-1251985;Reactome: R-HSA-8863795;Reactome: R-HSA-6811558;Reactome: R-HSA-2219530;Reactome: R-HSA-5673001	"GRB2 events in ERBB2 signaling";"ERBB2 Activates PTK6 Signaling";"PI3K events in ERBB4 signaling";"Signaling by ERBB2";"PIP3 activates AKT signaling";"SHC1 events in ERBB2 signaling";"PI3K events in ERBB2 signaling";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB4 signaling";"ERBB2 Regulates Cell Motility";"Signaling by ERBB4";"Nuclear signaling by ERBB4";"Downregulation of ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"RAF/MAP kinase cascade"
XP_053951527.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053948823.1	6	Reactome: R-HSA-416993;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-6811434;Reactome: R-HSA-204005	"Trafficking of GluR2-containing AMPA receptors";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"COPI-dependent Golgi-to-ER retrograde traffic";"COPII-mediated vesicle transport"
XP_053946251.1	11	Reactome: R-HSA-191273;MetaCyc: PWY-6383;MetaCyc: PWY-6859;MetaCyc: PWY-7560;MetaCyc: PWY-7524;MetaCyc: PWY-7391;MetaCyc: PWY-7102;MetaCyc: PWY-6174;MetaCyc: PWY-5123;MetaCyc: PWY-922;KEGG: 00900+5.3.3.2	"Cholesterol biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"All-trans-farnesol biosynthesis";"Methylerythritol phosphate pathway II";"Mevalonate pathway III (archaea)";"Isoprene biosynthesis II (engineered)";"Bisabolene biosynthesis (engineered)";"Mevalonate pathway II (archaea)";"Trans, trans-farnesyl diphosphate biosynthesis";"Mevalonate pathway I";"Terpenoid backbone biosynthesis"
XP_053952624.1	13	MetaCyc: PWY-5690;MetaCyc: PWY-5537;MetaCyc: PWY-5392;MetaCyc: PWY-6969;KEGG: 00720+6.2.1.5;KEGG: 00660+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-7384	"TCA cycle II (plants and fungi)";"Pyruvate fermentation to acetate V";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"C5-Branched dibasic acid metabolism";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)"
XP_053958784.1	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
XP_053948527.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6798695	"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation"
XP_053957738.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053946172.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053963730.1	6	Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_053966815.1	7	MetaCyc: PWY-3561;Reactome: R-HSA-1483166;Reactome: R-HSA-2029485;KEGG: 00565+3.1.4.4;MetaCyc: PWY-7039;Reactome: R-HSA-1483148;KEGG: 00564+3.1.4.4	"Choline biosynthesis III";"Synthesis of PA";"Role of phospholipids in phagocytosis";"Ether lipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Synthesis of PG";"Glycerophospholipid metabolism"
XP_053958057.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053960851.1	4	Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825	"Neddylation";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis"
XP_053949836.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053954491.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053969212.1	5	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Ion channel transport"
XP_053952182.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053952167.1	3	Reactome: R-HSA-420029;MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_053954674.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053958511.1	2	KEGG: 00970+6.1.1.14;Reactome: R-HSA-2151201	"Aminoacyl-tRNA biosynthesis";"Transcriptional activation of mitochondrial biogenesis"
XP_053965735.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053956316.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053954336.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Neddylation"
XP_053955833.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053960013.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053967997.1	3	Reactome: R-HSA-5689877;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394	"Josephin domain DUBs";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER"
XP_053947819.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_053964693.1	2	MetaCyc: PWY-7799;MetaCyc: PWY-7802	"Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)"
XP_053946211.1	2	Reactome: R-HSA-425393;Reactome: R-HSA-5223345	"Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events"
XP_053966866.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_053950467.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053963120.1	13	Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053946183.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053948114.1	1	KEGG: 00450+1.8.1.9	"Selenocompound metabolism"
XP_053954854.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-110320	"Ub-specific processing proteases";"Translesion Synthesis by POLH"
XP_053951629.1	20	KEGG: 00071+1.3.3.6;MetaCyc: PWY-7288;MetaCyc: PWY-7337;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-7854;MetaCyc: PWY-5136;MetaCyc: PWY-7574;Reactome: R-HSA-9033241;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-6920;MetaCyc: PWY-7291;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-6837;MetaCyc: PWY-7007;MetaCyc: PWY-7338;MetaCyc: PWY-7858;KEGG: 00410+1.3.3.6	"Fatty acid degradation";"Fatty acid beta-oxidation VII (yeast peroxisome)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Propanoyl-coa degradation II";"Peroxisomal protein import";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"6-gingerol analog biosynthesis (engineered)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Methyl ketone biosynthesis (engineered)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"beta-Alanine metabolism"
XP_053963141.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053945184.1	8	Reactome: R-HSA-69091;Reactome: R-HSA-69183;Reactome: R-HSA-68962;Reactome: R-HSA-174430;Reactome: R-HSA-69166;Reactome: R-HSA-174411;Reactome: R-HSA-68952;Reactome: R-HSA-113501	"Polymerase switching";"Processive synthesis on the lagging strand";"Activation of the pre-replicative complex";"Telomere C-strand synthesis initiation";"Removal of the Flap Intermediate";"Polymerase switching on the C-strand of the telomere";"DNA replication initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1"
XP_053949593.1	24	Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-983189;Reactome: R-HSA-190840;Reactome: R-HSA-8852276;Reactome: R-HSA-9609736;Reactome: R-HSA-6807878;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-1445148;Reactome: R-HSA-8955332;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-190861;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257	"RHO GTPases Activate Formins";"Recycling pathway of L1";"Kinesins";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Assembly and cell surface presentation of NMDA receptors";"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs";"HCMV Early Events";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Carboxyterminal post-translational modifications of tubulin";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"Aggrephagy";"Cilium Assembly";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Gap junction assembly";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion"
XP_053955087.1	3	KEGG: 00270+1.13.11.54;Reactome: R-HSA-1237112;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053969912.1	8	Reactome: R-HSA-113507;Reactome: R-HSA-68616;Reactome: R-HSA-68962;Reactome: R-HSA-68689;Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-68827	"E2F-enabled inhibition of pre-replication complex formation";"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex"
XP_053946068.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_053947859.1	2	Reactome: R-HSA-3359473;Reactome: R-HSA-196741	"Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD";"Cobalamin (Cbl, vitamin B12) transport and metabolism"
XP_053952173.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053968477.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_053955170.1	11	Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-163359	"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"G alpha (i) signalling events";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Glucagon signaling in metabolic regulation"
XP_053949354.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-8041;MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7619;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601	"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"
XP_053969171.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053947405.1	4	KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-6483;MetaCyc: PWY-7119	"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)"
XP_053954807.1	7	Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380320	"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes"
XP_053968468.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053957491.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053968245.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053963123.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053960239.1	3	Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Estrogen-dependent gene expression";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053968026.1	2	Reactome: R-HSA-201722;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex"
XP_053960232.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_053948789.1	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_053951601.1	1	Reactome: R-HSA-419037	"NCAM1 interactions"
XP_053957336.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053962505.1	33	Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-77075;Reactome: R-HSA-6782135;Reactome: R-HSA-73762;Reactome: R-HSA-167162;Reactome: R-HSA-6781827;Reactome: R-HSA-427413;Reactome: R-HSA-69202;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-113418;Reactome: R-HSA-6781823;Reactome: R-HSA-72086;Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-69273;Reactome: R-HSA-73772;Reactome: R-HSA-112382;Reactome: R-HSA-167161;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-69656;Reactome: R-HSA-75953;Reactome: R-HSA-8939236;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-5696395;Reactome: R-HSA-167246;Reactome: R-HSA-69231	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"Dual incision in TC-NER";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"NoRC negatively regulates rRNA expression";"Cyclin E associated events during G1/S transition";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Formation of the Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"mRNA Capping";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"Cyclin A/B1/B2 associated events during G2/M transition";"RNA Polymerase I Promoter Escape";"Formation of RNA Pol II elongation complex";"HIV Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Cyclin A:Cdk2-associated events at S phase entry";"RNA Polymerase II Transcription Initiation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of Incision Complex in GG-NER";"Tat-mediated elongation of the HIV-1 transcript";"Cyclin D associated events in G1"
XP_053957674.1	7	Reactome: R-HSA-5658034;Reactome: R-HSA-5632681;Reactome: R-HSA-5362798;Reactome: R-HSA-5632684;Reactome: R-HSA-373080;Reactome: R-HSA-5635838;Reactome: R-HSA-5358346	"HHAT G278V abrogates palmitoylation of Hh-Np";"Ligand-receptor interactions";"Release of Hh-Np from the secreting cell";"Hedgehog 'on' state";"Class B/2 (Secretin family receptors)";"Activation of SMO";"Hedgehog ligand biogenesis"
XP_053956750.1	16	Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72695	"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex"
XP_053969572.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053947969.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053958159.1	9	MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00604+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;MetaCyc: PWY-7883;KEGG: 00513+3.2.1.52;KEGG: 00511+3.2.1.52	"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Chitin degradation III (Serratia)";"Glycosphingolipid biosynthesis - ganglio series";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Anhydromuropeptides recycling II";"Various types of N-glycan biosynthesis";"Other glycan degradation"
XP_053948828.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053951712.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-419812	"G alpha (s) signalling events";"Calcitonin-like ligand receptors"
XP_053953364.1	11	Reactome: R-HSA-9013700;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-2122948;Reactome: R-HSA-9017802;Reactome: R-HSA-3928665;Reactome: R-HSA-2644606;Reactome: R-HSA-205043;Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-193692	"NOTCH4 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"Activated NOTCH1 Transmits Signal to the Nucleus";"Noncanonical activation of NOTCH3";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NRIF signals cell death from the nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulated proteolysis of p75NTR"
XP_053954738.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
XP_053959319.1	22	Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-432142;Reactome: R-HSA-6811558;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-5358747;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-2500257	"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Platelet sensitization by LDL";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S33 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"RAF activation";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Resolution of Sister Chromatid Cohesion"
XP_053952754.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053945712.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053962444.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_053945719.1	14	MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7619;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-7036	"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II"
XP_053952170.1	3	KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029;MetaCyc: PWY-7221	"Purine metabolism";"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis"
XP_053957814.1	12	MetaCyc: PWY-5856;Reactome: R-HSA-2142789;MetaCyc: PWY-7233;MetaCyc: PWY-6708;MetaCyc: PWY-5872;MetaCyc: PWY-5871;MetaCyc: PWY-5870;MetaCyc: PWY-7230;MetaCyc: PWY-5855;MetaCyc: PWY-5873;MetaCyc: PWY-5857;KEGG: 00130+2.1.1.222+2.1.1.64	"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis"
XP_053960939.1	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
XP_053969862.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_053948820.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053960932.1	7	Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-68877	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase"
XP_053952178.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053957549.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053957503.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053954508.1	2	MetaCyc: PWY-6981;KEGG: 00520+2.4.1.16	"Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism"
XP_053961097.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053957542.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053964297.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_053957807.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053957397.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053949935.1	4	MetaCyc: PWY-7546;Reactome: R-HSA-8849175;MetaCyc: PWY-6482;Reactome: R-HSA-5358493	"Diphthamide biosynthesis II (eukaryotes)";"Threonine catabolism";"Diphthamide biosynthesis I (archaea)";"Synthesis of diphthamide-EEF2"
XP_053955189.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902	"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation"
XP_053966193.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_053963491.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Amino acids regulate mTORC1"
XP_053966327.1	3	Reactome: R-HSA-383280;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"Nuclear Receptor transcription pathway";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_053951759.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053964698.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053955182.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053968460.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053955167.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053960010.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_053946747.1	1	Reactome: R-HSA-390651	"Dopamine receptors"
XP_053952833.1	1	Reactome: R-HSA-77108	"Utilization of Ketone Bodies"
XP_053957854.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053955830.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053963674.1	4	Reactome: R-HSA-674695;Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
XP_053959359.1	22	Reactome: R-HSA-6811558;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-432142;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-5673000;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-2500257;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-5358747	"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"Platelet sensitization by LDL";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RAF activation";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"Resolution of Sister Chromatid Cohesion";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S33 mutants of beta-catenin aren't phosphorylated"
XP_053958182.1	20	Reactome: R-HSA-9033241;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-6920;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7288;MetaCyc: PWY-7337;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7854;MetaCyc: PWY-7574;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7291;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-6837;MetaCyc: PWY-7007;MetaCyc: PWY-7338;MetaCyc: PWY-7858	"Peroxisomal protein import";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid degradation";"Fatty acid beta-oxidation VII (yeast peroxisome)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Propanoyl-coa degradation II";"beta-Alanine metabolism";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Methyl ketone biosynthesis (engineered)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II"
XP_053965460.1	5	KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;MetaCyc: PWY-7269;Reactome: R-HSA-196807;MetaCyc: PWY-5083	"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation"
XP_053956780.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_053962792.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_053947217.1	4	MetaCyc: PWY-7511;Reactome: R-HSA-9020702;Reactome: R-HSA-975144;Reactome: R-HSA-937039	"Protein ubiquitination";"Interleukin-1 signaling";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"IRAK1 recruits IKK complex"
XP_053962463.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism"
XP_053953302.1	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
XP_053949992.1	5	Reactome: R-HSA-6804757;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-1257604;Reactome: R-HSA-5674400	"Regulation of TP53 Degradation";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling";"Constitutive Signaling by AKT1 E17K in Cancer"
XP_053962846.1	2	Reactome: R-HSA-6804758;Reactome: R-HSA-3214847	"Regulation of TP53 Activity through Acetylation";"HATs acetylate histones"
XP_053969513.1	10	Reactome: R-HSA-2151209;Reactome: R-HSA-1632852;Reactome: R-HSA-163680;Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-380972;Reactome: R-HSA-6804756;Reactome: R-HSA-200425;Reactome: R-HSA-9619483	"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Macroautophagy";"AMPK inhibits chREBP transcriptional activation activity";"Lipophagy";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of TP53 Activity through Phosphorylation";"Carnitine metabolism";"Activation of AMPK downstream of NMDARs"
XP_053952511.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053946774.1	2	Reactome: R-HSA-181429;Reactome: R-HSA-212676	"Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle"
XP_053953343.1	8	KEGG: 04926+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Major pathway of rRNA processing in the nucleolus and cytosol";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053959776.1	2	Reactome: R-HSA-416993;Reactome: R-HSA-202733	"Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall"
XP_053969817.1	2	Reactome: R-HSA-5627123;Reactome: R-HSA-8856828	"RHO GTPases activate PAKs";"Clathrin-mediated endocytosis"
XP_053947650.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053950906.1	3	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
XP_053957240.1	1	Reactome: R-HSA-71288	"Creatine metabolism"
XP_053951841.1	9	Reactome: R-HSA-6802946;Reactome: R-HSA-114608;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-6798695;Reactome: R-HSA-6802955;Reactome: R-HSA-445355	"Signaling by moderate kinase activity BRAF mutants";"Platelet degranulation";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"Neutrophil degranulation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Smooth Muscle Contraction"
XP_053970171.1	3	MetaCyc: PWY-7942;KEGG: 00480+4.3.2.7;Reactome: R-HSA-174403	"5-oxo-L-proline metabolism";"Glutathione metabolism";"Glutathione synthesis and recycling"
XP_053965945.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053952345.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053960177.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053945773.1	2	Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_053946118.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053969677.1	8	KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1	"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Activation of RAC1";"Human cytomegalovirus infection"
XP_053960995.1	4	Reactome: R-HSA-8856828;Reactome: R-HSA-3928662;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_053966291.1	2	Reactome: R-HSA-202433;Reactome: R-HSA-376176	"Generation of second messenger molecules";"Signaling by ROBO receptors"
XP_053959373.1	6	Reactome: R-HSA-5654706;Reactome: R-HSA-9028731;Reactome: R-HSA-5654712;Reactome: R-HSA-5673001;Reactome: R-HSA-5654700;Reactome: R-HSA-5654693	"FRS-mediated FGFR3 signaling";"Activated NTRK2 signals through FRS2 and FRS3";"FRS-mediated FGFR4 signaling";"RAF/MAP kinase cascade";"FRS-mediated FGFR2 signaling";"FRS-mediated FGFR1 signaling"
XP_053953746.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053947257.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_053960088.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053950324.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053951043.1	8	Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-5689880;Reactome: R-HSA-5620912	"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Ub-specific processing proteases";"Anchoring of the basal body to the plasma membrane"
XP_053969394.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053957248.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053967899.1	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
XP_053956822.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053961794.1	1	Reactome: R-HSA-6804756	"Regulation of TP53 Activity through Phosphorylation"
XP_053948719.1	2	Reactome: R-HSA-8951671;Reactome: R-HSA-2032785	"RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression"
XP_053952639.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053969857.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053946305.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_053969553.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_053957940.1	2	Reactome: R-HSA-8873719;Reactome: R-HSA-6811438	"RAB geranylgeranylation";"Intra-Golgi traffic"
XP_053957884.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053959367.1	22	Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-68877;Reactome: R-HSA-5358751;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-6811558;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749	"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Beta-catenin phosphorylation cascade";"RAF activation";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated"
XP_053959382.1	17	Reactome: R-HSA-75035;Reactome: R-HSA-6804756;Reactome: R-HSA-176187;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5693607;Reactome: R-HSA-6796648;Reactome: R-HSA-8953750;Reactome: R-HSA-69601;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-69473;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693616;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-1433557;KEGG: 04150+2.7.11.1	"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Regulation of TP53 Activity through Phosphorylation";"Activation of ATR in response to replication stress";"Human cytomegalovirus infection";"Processing of DNA double-strand break ends";"TP53 Regulates Transcription of DNA Repair Genes";"Transcriptional Regulation by E2F6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Human immunodeficiency virus 1 infection";"Thermogenesis";"G2/M DNA damage checkpoint";"Relaxin signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Signaling by SCF-KIT";"mTOR signaling pathway"
XP_053965026.1	13	Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053969270.1	6	KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_053969663.1	5	Reactome: R-HSA-72165;Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
XP_053961556.1	6	Reactome: R-HSA-381426;Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-8957275;Reactome: R-HSA-2173796;Reactome: R-HSA-5626467	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"Post-translational protein phosphorylation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"RHO GTPases activate IQGAPs"
XP_053965468.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_053967343.1	2	Reactome: R-HSA-6807505;Reactome: R-HSA-72163	"RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway"
XP_053967309.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053951767.1	2	KEGG: 00760+2.3.1.286;Reactome: R-HSA-2151201	"Nicotinate and nicotinamide metabolism";"Transcriptional activation of mitochondrial biogenesis"
XP_053964348.1	13	Reactome: R-HSA-196757;MetaCyc: PWY-6613;MetaCyc: PWY-7909;MetaCyc: PWY-2201;MetaCyc: PWY-3841;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-5497;MetaCyc: PWY-2161;MetaCyc: PWY-1722;KEGG: 00670+1.5.1.5+3.5.4.9;KEGG: 00720+6.3.4.3;KEGG: 00670+6.3.4.3;MetaCyc: PWY-5030	"Metabolism of folate and pterines";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"Folate transformations I";"Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"Purine nucleobases degradation II (anaerobic)";"Folate polyglutamylation";"Formate assimilation into 5,10-methylenetetrahydrofolate";"One carbon pool by folate";"Carbon fixation pathways in prokaryotes";"One carbon pool by folate";"L-histidine degradation III"
XP_053957647.1	14	KEGG: 00564+2.3.1.42;MetaCyc: PWY-7587;Reactome: R-HSA-9033241;MetaCyc: PWY-8055;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.15;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.15;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-5667;MetaCyc: PWY-8053;Reactome: R-HSA-75896	"Glycerophospholipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Peroxisomal protein import";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis II";"Plasmalogen biosynthesis"
XP_053966991.1	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis"
XP_053963416.1	4	Reactome: R-HSA-351202;KEGG: 00480+2.5.1.16;KEGG: 00270+2.5.1.16;KEGG: 00330+2.5.1.16	"Metabolism of polyamines";"Glutathione metabolism";"Cysteine and methionine metabolism";"Arginine and proline metabolism"
XP_053962998.1	7	Reactome: R-HSA-8856828;Reactome: R-HSA-1855204;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1660499	"Clathrin-mediated endocytosis";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the plasma membrane"
XP_053963837.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053945980.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053962636.1	9	Reactome: R-HSA-69205;Reactome: R-HSA-68827;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68689;Reactome: R-HSA-113507;Reactome: R-HSA-68962;Reactome: R-HSA-68616	"G1/S-Specific Transcription";"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"CDC6 association with the ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication"
XP_053951662.1	5	Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-6814122	"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_053948877.1	3	KEGG: 00970+6.1.1.19;Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
XP_053967452.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053962374.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950348.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_053948032.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053966294.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_053961383.1	6	KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I"
XP_053967459.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053963533.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053966826.1	1	Reactome: R-HSA-379716	"Cytosolic tRNA aminoacylation"
XP_053961006.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_053954163.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053945095.1	5	KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2;MetaCyc: PWY-5084	"Citrate cycle (TCA cycle)";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA"
XP_053948958.1	1	Reactome: R-HSA-376172	"DSCAM interactions"
XP_053970174.1	8	Reactome: R-HSA-1989781;MetaCyc: PWY-7391;MetaCyc: PWY-7524;Reactome: R-HSA-2426168;MetaCyc: PWY-6174;KEGG: 00900+1.1.1.34;Reactome: R-HSA-191273;MetaCyc: PWY-922	"PPARA activates gene expression";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway III (archaea)";"Activation of gene expression by SREBF (SREBP)";"Mevalonate pathway II (archaea)";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"Mevalonate pathway I"
XP_053945662.1	4	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"DARPP-32 events";"T cell receptor signaling pathway"
XP_053955974.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_053969783.1	52	Reactome: R-HSA-72163;Reactome: R-HSA-73863;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-77075;Reactome: R-HSA-167243;Reactome: R-HSA-167160;Reactome: R-HSA-73762;Reactome: R-HSA-167287;Reactome: R-HSA-427413;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-72203;Reactome: R-HSA-73772;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-72165;Reactome: R-HSA-167158;Reactome: R-HSA-6782210;Reactome: R-HSA-8851708;Reactome: R-HSA-5617472;Reactome: R-HSA-76066;Reactome: R-HSA-6803529;Reactome: R-HSA-5250924;Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-168325;Reactome: R-HSA-6781823;Reactome: R-HSA-167290;Reactome: R-HSA-203927;Reactome: R-HSA-113418;Reactome: R-HSA-73776;Reactome: R-HSA-76061;Reactome: R-HSA-6781827;Reactome: R-HSA-167162;Reactome: R-HSA-6782135;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-5578749;Reactome: R-HSA-76071;Reactome: R-HSA-5601884;Reactome: R-HSA-167238;Reactome: R-HSA-167200;Reactome: R-HSA-1834949;Reactome: R-HSA-9018519;Reactome: R-HSA-75953;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-167242	"mRNA Splicing - Major Pathway";"RNA Polymerase I Transcription Termination";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"Tat-mediated HIV elongation arrest and recovery";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Transcription Initiation";"HIV elongation arrest and recovery";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase I Promoter Escape";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"mRNA Splicing - Minor Pathway";"Formation of the HIV-1 Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Signaling by FGFR2 IIIa TM";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"FGFR2 alternative splicing";"B-WICH complex positively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"Viral Messenger RNA Synthesis";"Formation of TC-NER Pre-Incision Complex";"Pausing and recovery of HIV elongation";"MicroRNA (miRNA) biogenesis";"Formation of the Early Elongation Complex";"RNA Polymerase II Promoter Escape";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II HIV Promoter Escape";"Dual incision in TC-NER";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"Transcriptional regulation by small RNAs";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"PIWI-interacting RNA (piRNA) biogenesis";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Cytosolic sensors of pathogen-associated DNA";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Initiation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat"
XP_053955398.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053958947.1	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
XP_053951844.1	9	Reactome: R-HSA-445355;Reactome: R-HSA-6802955;Reactome: R-HSA-6798695;Reactome: R-HSA-6802952;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-9649948;Reactome: R-HSA-6802946;Reactome: R-HSA-114608	"Smooth Muscle Contraction";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Neutrophil degranulation";"Signaling by BRAF and RAF fusions";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Signaling by moderate kinase activity BRAF mutants";"Platelet degranulation"
XP_053956668.1	4	Reactome: R-HSA-389661;Reactome: R-HSA-77289;Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Glyoxylate metabolism and glycine degradation";"Mitochondrial Fatty Acid Beta-Oxidation";"Complex I biogenesis";"Respiratory electron transport"
XP_053965293.1	1	Reactome: R-HSA-5689603	"UCH proteinases"
XP_053962290.1	3	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-6807505	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes"
XP_053948617.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-8873719	"RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation"
XP_053945288.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053953419.1	7	Reactome: R-HSA-1855183;MetaCyc: PWY-4702;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.25;KEGG: 04070+3.1.3.25;MetaCyc: PWY-2301;KEGG: 00521+3.1.3.25	"Synthesis of IP2, IP, and Ins in the cytosol";"Phytate degradation I";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Myo-inositol biosynthesis";"Streptomycin biosynthesis"
XP_053946809.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053952514.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053948910.1	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
XP_053955029.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_053951552.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_053965165.1	11	Reactome: R-HSA-3656253;Reactome: R-HSA-4420332;Reactome: R-HSA-1971475;Reactome: R-HSA-3560801;Reactome: R-HSA-202733;Reactome: R-HSA-975634;Reactome: R-HSA-3000170;Reactome: R-HSA-2022928;Reactome: R-HSA-3560783;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096	"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GAT3 causes JDSSDHD";"Cell surface interactions at the vascular wall";"Retinoid metabolism and transport";"Syndecan interactions";"HS-GAG biosynthesis";"Defective B4GALT7 causes EDS, progeroid type";"Defective EXT2 causes exostoses 2";"HS-GAG degradation"
XP_053951631.1	1	Reactome: R-HSA-196741	"Cobalamin (Cbl, vitamin B12) transport and metabolism"
XP_053951559.1	14	MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-6453;MetaCyc: PWY-7589;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51	"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism"
XP_053967395.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_053954088.1	6	MetaCyc: PWY-6906;KEGG: 00520+5.4.2.3;KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749;Reactome: R-HSA-446210;MetaCyc: PWY-5514	"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I";"Synthesis of UDP-N-acetyl-glucosamine";"UDP-N-acetyl-D-galactosamine biosynthesis II"
XP_053969386.1	3	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-6807505	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes"
XP_053948250.1	24	Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-392451;Reactome: R-HSA-418217;Reactome: R-HSA-202040;Reactome: R-HSA-418555;Reactome: R-HSA-4086398;Reactome: R-HSA-432040;Reactome: R-HSA-400042;Reactome: R-HSA-420092;Reactome: R-HSA-500657;Reactome: R-HSA-428930;Reactome: R-HSA-8964616;Reactome: R-HSA-418594;Reactome: R-HSA-456926;Reactome: R-HSA-8964315;Reactome: R-HSA-163359;Reactome: R-HSA-9009391;Reactome: R-HSA-6814122;Reactome: R-HSA-416482;Reactome: R-HSA-392851;Reactome: R-HSA-381676;Reactome: R-HSA-392170;Reactome: R-HSA-418592	"G alpha (z) signalling events";"G alpha (q) signalling events";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through PLC beta";"G-protein activation";"G alpha (s) signalling events";"Ca2+ pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adrenaline,noradrenaline inhibits insulin secretion";"Glucagon-type ligand receptors";"Presynaptic function of Kainate receptors";"Thromboxane signalling through TP receptor";"G beta:gamma signalling through CDC42";"G alpha (i) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through BTK";"Glucagon signaling in metabolic regulation";"Extra-nuclear estrogen signaling";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (12/13) signalling events";"Prostacyclin signalling through prostacyclin receptor";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 12";"ADP signalling through P2Y purinoceptor 1"
XP_053962705.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053952849.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053945280.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053962298.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053955800.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053961372.1	3	MetaCyc: PWY-6689;MetaCyc: PWY-7803;Reactome: R-HSA-6784531	"Trna splicing I";"Trna splicing II";"tRNA processing in the nucleus"
XP_053946020.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053954080.1	7	KEGG: 00330+2.5.1.16;KEGG: 00330+2.5.1.22;KEGG: 00270+2.5.1.16;KEGG: 00270+2.5.1.22;Reactome: R-HSA-351202;KEGG: 00480+2.5.1.16;KEGG: 00480+2.5.1.22	"Arginine and proline metabolism";"Arginine and proline metabolism";"Cysteine and methionine metabolism";"Cysteine and methionine metabolism";"Metabolism of polyamines";"Glutathione metabolism";"Glutathione metabolism"
XP_053948258.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053961433.1	6	KEGG: 00720+4.2.1.3;KEGG: 00290+4.2.1.33;KEGG: 00630+4.2.1.3;Reactome: R-HSA-1268020;KEGG: 00020+4.2.1.3;Reactome: R-HSA-71403	"Carbon fixation pathways in prokaryotes";"Valine, leucine and isoleucine biosynthesis";"Glyoxylate and dicarboxylate metabolism";"Mitochondrial protein import";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)"
XP_053948582.1	4	Reactome: R-HSA-3000170;Reactome: R-HSA-2129379;Reactome: R-HSA-3000178;Reactome: R-HSA-216083	"Syndecan interactions";"Molecules associated with elastic fibres";"ECM proteoglycans";"Integrin cell surface interactions"
XP_053957881.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_053948863.1	5	Reactome: R-HSA-4793954;Reactome: R-HSA-532668;KEGG: 00510+3.2.1.106;MetaCyc: PWY-7919;MetaCyc: PWY-7918	"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"N-Glycan biosynthesis";"Protein N-glycosylation processing phase (plants and animals)";"Protein N-glycosylation processing phase (yeast)"
XP_053948589.1	9	MetaCyc: PWY-7533;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7112;KEGG: 00980+2.5.1.18;MetaCyc: PWY-4061;MetaCyc: PWY-6842;Reactome: R-HSA-156590;KEGG: 00983+2.5.1.18;KEGG: 00480+2.5.1.18	"Gliotoxin biosynthesis";"Drug metabolism - cytochrome P450";"4-hydroxy-2-nonenal detoxification";"Metabolism of xenobiotics by cytochrome P450";"Glutathione-mediated detoxification I";"Glutathione-mediated detoxification II";"Glutathione conjugation";"Drug metabolism - other enzymes";"Glutathione metabolism"
XP_053948918.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053969436.1	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_053954538.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053963742.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053957533.1	3	Reactome: R-HSA-9603798;Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Class I peroxisomal membrane protein import";"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_053950340.1	8	Reactome: R-HSA-380972;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-3371571;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852	"Energy dependent regulation of mTOR by LKB1-AMPK";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"Regulation of PTEN gene transcription";"mTOR signalling";"HSF1-dependent transactivation";"TP53 Regulates Metabolic Genes";"Macroautophagy"
XP_053958648.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053963703.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053963749.1	14	MetaCyc: PWY-3781;MetaCyc: PWY-6969;Reactome: R-HSA-611105;KEGG: 00720+1.3.5.1;MetaCyc: PWY-5690;KEGG: 00190+1.3.5.1;MetaCyc: PWY-7254;KEGG: 00020+1.3.5.1;MetaCyc: PWY-7279;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-4302;KEGG: 00650+1.3.5.1;MetaCyc: PWY-561	"Aerobic respiration I (cytochrome c)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Respiratory electron transport";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Oxidative phosphorylation";"TCA cycle VII (acetate-producers)";"Citrate cycle (TCA cycle)";"Aerobic respiration II (cytochrome c) (yeast)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Aerobic respiration III (alternative oxidase pathway)";"Butanoate metabolism";"Superpathway of glyoxylate cycle and fatty acid degradation"
XP_053954700.1	4	MetaCyc: PWY-8040;KEGG: 00473+5.1.1.1;MetaCyc: PWY-8072;MetaCyc: PWY-7383	"Ansatrienin biosynthesis";"D-Alanine metabolism";"Alanine racemization";"Anaerobic energy metabolism (invertebrates, cytosol)"
XP_053945519.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053953452.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_053957079.1	9	Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-75953	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation"
XP_053956660.1	4	Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814;Reactome: R-HSA-2022090	"Collagen chain trimerization";"Collagen degradation";"Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures"
XP_053951988.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_053956273.1	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
XP_053950321.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053962697.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053968423.1	3	MetaCyc: PWY-7533;Reactome: R-HSA-5423646;Reactome: R-HSA-2142691	"Gliotoxin biosynthesis";"Aflatoxin activation and detoxification";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
XP_053952751.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053947103.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053951210.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053954010.1	4	Reactome: R-HSA-5625970;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"RHO GTPases activate KTN1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053956030.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053962441.1	3	Reactome: R-HSA-9645722;Reactome: R-HSA-140837;Reactome: R-HSA-111471	"Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function";"Intrinsic Pathway of Fibrin Clot Formation";"Apoptotic factor-mediated response"
XP_053959855.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053945657.1	4	KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"DARPP-32 events";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053969753.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053952475.1	1	Reactome: R-HSA-264876	"Insulin processing"
XP_053960128.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053961353.1	24	Reactome: R-HSA-8963896;Reactome: R-HSA-5621575;Reactome: R-HSA-9010642;Reactome: R-HSA-180024;Reactome: R-HSA-9634600;Reactome: R-HSA-5610785;KEGG: 04150+2.7.11.11;Reactome: R-HSA-392517;Reactome: R-HSA-163358;Reactome: R-HSA-983231;Reactome: R-HSA-111931;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-5610783;Reactome: R-HSA-381676;Reactome: R-HSA-4420097;Reactome: R-HSA-163560;Reactome: R-HSA-432040;Reactome: R-HSA-442720;Reactome: R-HSA-422356;Reactome: R-HSA-8853659;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128	"HDL assembly";"CD209 (DC-SIGN) signaling";"ROBO receptors bind AKAP5";"DARPP-32 events";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"GLI3 is processed to GLI3R by the proteasome";"mTOR signaling pathway";"Rap1 signalling";"PKA-mediated phosphorylation of key metabolic factors";"Factors involved in megakaryocyte development and platelet production";"PKA-mediated phosphorylation of CREB";"PKA activation";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"Degradation of GLI2 by the proteasome";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"VEGFA-VEGFR2 Pathway";"Triglyceride catabolism";"Vasopressin regulates renal water homeostasis via Aquaporins";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Regulation of insulin secretion";"RET signaling";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling"
XP_053947934.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_053945210.1	18	MetaCyc: PWY-7783;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-6803;Reactome: R-HSA-1482922;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482839;Reactome: R-HSA-1482801;MetaCyc: PWY-7417;MetaCyc: PWY-8053;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925	"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PI";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PE";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG"
XP_053962420.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_053963851.1	5	MetaCyc: PWY-6749;Reactome: R-HSA-446210;MetaCyc: PWY-8013;KEGG: 00250+2.6.1.16;KEGG: 00520+2.6.1.16	"CMP-legionaminate biosynthesis I";"Synthesis of UDP-N-acetyl-glucosamine";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Amino sugar and nucleotide sugar metabolism"
XP_053953339.1	9	Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-6807505;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-674695	"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events"
XP_053952034.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053945589.1	8	KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Signaling by Hippo";"Human papillomavirus infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053945863.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
XP_053945567.1	3	KEGG: 00680+3.1.3.3;Reactome: R-HSA-977347;KEGG: 00260+3.1.3.3	"Methane metabolism";"Serine biosynthesis";"Glycine, serine and threonine metabolism"
XP_053961756.1	6	KEGG: 00512+2.4.1.122;MetaCyc: PWY-7433;Reactome: R-HSA-5083632;KEGG: 00514+2.4.1.122;MetaCyc: PWY-7290;Reactome: R-HSA-913709	"Mucin type O-glycan biosynthesis";"Mucin core 1 and core 2 O-glycosylation";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Other types of O-glycan biosynthesis";"Escherichia coli serotype O86 O-antigen biosynthesis";"O-linked glycosylation of mucins"
XP_053966424.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053954939.1	1	Reactome: R-HSA-419771	"Opsins"
XP_053956919.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053957851.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053969713.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_053945617.1	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
XP_053952711.1	1	Reactome: R-HSA-5419276	"Mitochondrial translation termination"
XP_053967332.1	9	MetaCyc: PWY-6147;MetaCyc: PWY-5664;MetaCyc: PWY-7852;Reactome: R-HSA-1474151;MetaCyc: PWY-6983;MetaCyc: PWY-5663;KEGG: 00790+3.5.4.16;MetaCyc: PWY-7442;MetaCyc: PWY-6703	"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Erythro-tetrahydrobiopterin biosynthesis II";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Threo-tetrahydrobiopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Preq0 biosynthesis"
XP_053963671.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053951250.1	4	Reactome: R-HSA-4719377;Reactome: R-HSA-4719360;Reactome: R-HSA-162699;Reactome: R-HSA-4717374	"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Synthesis of dolichyl-phosphate mannose";"Defective DPM1 causes DPM1-CDG (CDG-1e)"
XP_053958808.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_053950236.1	26	Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-5621575;Reactome: R-HSA-9013508;Reactome: R-HSA-1368082;Reactome: R-HSA-1234158;Reactome: R-HSA-3134973;Reactome: R-HSA-400253;Reactome: R-HSA-3899300;Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-9617629;Reactome: R-HSA-3371568;Reactome: R-HSA-8866907;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-918233;Reactome: R-HSA-933541;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-9614657	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"CD209 (DC-SIGN) signaling";"NOTCH3 Intracellular Domain Regulates Transcription";"RORA activates gene expression";"Regulation of gene expression by Hypoxia-inducible Factor";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Circadian Clock";"SUMOylation of transcription cofactors";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"Attenuation phase";"Activation of the TFAP2 (AP-2) family of transcription factors";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF3-dependent IRF activation pathway";"TRAF6 mediated IRF7 activation";"PPARA activates gene expression";"Estrogen-dependent gene expression";"FOXO-mediated transcription of cell death genes"
XP_053958022.1	3	KEGG: 00511+3.2.1.45;KEGG: 00600+3.2.1.45;Reactome: R-HSA-1660662	"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid metabolism"
XP_053962592.1	56	Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-5689880;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-4608870;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-450408;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-174184;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541	"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Ub-specific processing proteases";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Asymmetric localization of PCP proteins";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Neddylation";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway"
XP_053962599.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053969927.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053963811.1	6	Reactome: R-HSA-416993;Reactome: R-HSA-5099900;Reactome: R-HSA-76005;Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114516	"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD4";"Response to elevated platelet cytosolic Ca2+";"G alpha (z) signalling events";"Phosphatidylinositol signaling system";"Disinhibition of SNARE formation"
XP_053952643.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_053950997.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_053960141.1	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
XP_053962055.1	27	Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-3301854;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-159227;Reactome: R-HSA-9609690	"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Nuclear Pore Complex (NPC) Disassembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events"
XP_053953546.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053967361.1	13	Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053955947.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053951039.1	8	Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-5689880	"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"Ub-specific processing proteases"
XP_053948662.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_053962066.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053945958.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053969620.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_053960120.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053947760.1	2	Reactome: R-HSA-1799339;Reactome: R-HSA-381038	"SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes"
XP_053965191.1	5	Reactome: R-HSA-2132295;Reactome: R-HSA-1660662;Reactome: R-HSA-4341670;Reactome: R-HSA-6798695;Reactome: R-HSA-4085001	"MHC class II antigen presentation";"Glycosphingolipid metabolism";"Defective NEU1 causes sialidosis";"Neutrophil degranulation";"Sialic acid metabolism"
XP_053956952.1	8	MetaCyc: PWY-8086;KEGG: 00620+1.1.1.27;KEGG: 00270+1.1.1.27;Reactome: R-HSA-70268;MetaCyc: PWY-5481;KEGG: 00010+1.1.1.27;MetaCyc: PWY-6901;KEGG: 00640+1.1.1.27	"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Cysteine and methionine metabolism";"Pyruvate metabolism";"Pyruvate fermentation to (S)-lactate";"Glycolysis / Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Propanoate metabolism"
XP_053951307.1	4	KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541;Reactome: R-HSA-499943;MetaCyc: PWY-7221	"Purine metabolism";"Abacavir metabolism";"Interconversion of nucleotide di- and triphosphates";"Guanosine ribonucleotides de novo biosynthesis"
XP_053959596.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053961642.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053964498.1	17	Reactome: R-HSA-163765;MetaCyc: PWY-4381;Reactome: R-HSA-3371599;KEGG: 00720+6.4.1.2;MetaCyc: PWY-5744;Reactome: R-HSA-196780;Reactome: R-HSA-2426168;MetaCyc: PWY-5966-1;KEGG: 00620+6.4.1.2;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6722;MetaCyc: PWY-6679;MetaCyc: PWY-5789;KEGG: 00640+6.4.1.2;KEGG: 00254+6.4.1.2;MetaCyc: PWY-5743;Reactome: R-HSA-200425	"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (bacteria and plants)";"Defective HLCS causes multiple carboxylase deficiency";"Carbon fixation pathways in prokaryotes";"Glyoxylate assimilation";"Biotin transport and metabolism";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Pyruvate metabolism";"Fatty acid biosynthesis";"Candicidin biosynthesis";"Jadomycin biosynthesis";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Propanoate metabolism";"Aflatoxin biosynthesis";"3-hydroxypropanoate cycle";"Carnitine metabolism"
XP_053967769.1	4	Reactome: R-HSA-8875555;Reactome: R-HSA-8875656;Reactome: R-HSA-912631;Reactome: R-HSA-186763	"MET activates RAP1 and RAC1";"MET receptor recycling";"Regulation of signaling by CBL";"Downstream signal transduction"
XP_053949629.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053963691.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053960526.1	42	Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-2299718;Reactome: R-HSA-3214842;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-427413;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-73728;Reactome: R-HSA-3214815;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-5334118;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-977225;Reactome: R-HSA-5693571;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-9018519;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300	"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Condensation of Prophase Chromosomes";"HDMs demethylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"NoRC negatively regulates rRNA expression";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Opening";"HDACs deacetylate histones";"Meiotic synapsis";"Packaging Of Telomere Ends";"DNA methylation";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Amyloid fiber formation";"Nonhomologous End-Joining (NHEJ)";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Estrogen-dependent gene expression";"Meiotic recombination";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA"
XP_053950810.1	2	Reactome: R-HSA-5576886;Reactome: R-HSA-1299308	"Phase 4 - resting membrane potential";"Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)"
XP_053962033.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053948434.1	10	Reactome: R-HSA-442742;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-444257;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-437239	"CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"RSK activation";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Recycling pathway of L1"
XP_053959707.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053963474.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053951354.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053946765.1	2	Reactome: R-HSA-6783984;KEGG: 00260+1.4.4.2	"Glycine degradation";"Glycine, serine and threonine metabolism"
XP_053959062.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_053945593.1	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Signaling by Hippo";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053959695.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_053965919.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_053955424.1	9	Reactome: R-HSA-68827;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-69017;Reactome: R-HSA-68689;Reactome: R-HSA-68962	"CDT1 association with the CDC6:ORC:origin complex";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"CDK-mediated phosphorylation and removal of Cdc6";"CDC6 association with the ORC:origin complex";"Activation of the pre-replicative complex"
XP_053964522.1	13	Reactome: R-HSA-975163;Reactome: R-HSA-450302;Reactome: R-HSA-9014325;Reactome: R-HSA-937072;Reactome: R-HSA-9020702;Reactome: R-HSA-2871837;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-445989;Reactome: R-HSA-9645460;Reactome: R-HSA-937042;Reactome: R-HSA-450321;Reactome: R-HSA-5607764	"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"activated TAK1 mediates p38 MAPK activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Interleukin-1 signaling";"FCERI mediated NF-kB activation";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Alpha-protein kinase 1 signaling pathway";"IRAK2 mediated activation of TAK1 complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"CLEC7A (Dectin-1) signaling"
XP_053958378.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053951897.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053948075.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053969444.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053961485.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
XP_053959581.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_053950850.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053967501.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_053962644.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053947338.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053950277.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053967121.1	6	KEGG: 04070+2.7.11.13;Reactome: R-HSA-114516;Reactome: R-HSA-76005;Reactome: R-HSA-418597;Reactome: R-HSA-416993;Reactome: R-HSA-5099900	"Phosphatidylinositol signaling system";"Disinhibition of SNARE formation";"Response to elevated platelet cytosolic Ca2+";"G alpha (z) signalling events";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD4"
XP_053964490.1	3	Reactome: R-HSA-3214858;Reactome: R-HSA-191859;Reactome: R-HSA-6804760	"RMTs methylate histone arginines";"snRNP Assembly";"Regulation of TP53 Activity through Methylation"
XP_053957691.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053953769.1	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
XP_053958826.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053953762.1	7	Reactome: R-HSA-2644606;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus"
XP_053965219.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053967140.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_053959833.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053952352.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053969735.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_053962831.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053952359.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053946716.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053959714.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053955826.1	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
XP_053946383.1	5	KEGG: 00240+2.4.2.3;MetaCyc: PWY-5532;Reactome: R-HSA-73621;KEGG: 00983+2.4.2.3;Reactome: R-HSA-73614	"Pyrimidine metabolism";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine catabolism";"Drug metabolism - other enzymes";"Pyrimidine salvage"
XP_053947246.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053962278.1	10	KEGG: 00010+2.7.1.11;KEGG: 00051+2.7.1.11;Reactome: R-HSA-70171;MetaCyc: PWY-1861;KEGG: 00680+2.7.1.11;KEGG: 00030+2.7.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-7385;KEGG: 00052+2.7.1.11;MetaCyc: PWY-1042	"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Methane metabolism";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)";"1,3-propanediol biosynthesis (engineered)";"Galactose metabolism";"Glycolysis IV (plant cytosol)"
XP_053965668.1	3	Reactome: R-HSA-4090294;Reactome: R-HSA-3232118;Reactome: R-HSA-3899300	"SUMOylation of intracellular receptors";"SUMOylation of transcription factors";"SUMOylation of transcription cofactors"
XP_053950729.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053969799.1	16	Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053969846.1	5	Reactome: R-HSA-427413;Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-73762	"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation"
XP_053953375.1	1	Reactome: R-HSA-70171	"Glycolysis"
XP_053947458.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053959511.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053961399.1	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
XP_053946786.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053949527.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053961843.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053961771.1	2	Reactome: R-HSA-2299718;Reactome: R-HSA-2514853	"Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes"
XP_053957665.1	2	Reactome: R-HSA-4086398;Reactome: R-HSA-418457	"Ca2+ pathway";"cGMP effects"
XP_053949823.1	3	Reactome: R-HSA-5579007;Reactome: R-HSA-5423646;KEGG: 00220+3.5.1.14	"Defective ACY1 causes encephalopathy";"Aflatoxin activation and detoxification";"Arginine biosynthesis"
XP_053961547.1	6	Reactome: R-HSA-2173796;Reactome: R-HSA-5626467;Reactome: R-HSA-8957275;Reactome: R-HSA-3769402;Reactome: R-HSA-381426;Reactome: R-HSA-201722	"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"RHO GTPases activate IQGAPs";"Post-translational protein phosphorylation";"Deactivation of the beta-catenin transactivating complex";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Formation of the beta-catenin:TCF transactivating complex"
XP_053962970.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_053959057.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_053969371.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2"
XP_053953717.1	4	Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_053965289.1	2	Reactome: R-HSA-975957;Reactome: R-HSA-9010553	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
XP_053955370.1	1	Reactome: R-HSA-4419969	"Depolymerisation of the Nuclear Lamina"
XP_053959345.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053951384.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053949048.1	40	Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-72163;Reactome: R-HSA-203927;Reactome: R-HSA-167290;Reactome: R-HSA-6781823;Reactome: R-HSA-113418;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-77075;Reactome: R-HSA-167160;Reactome: R-HSA-5578749;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-72203;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-5601884;Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-6782210;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-72165;Reactome: R-HSA-5617472;Reactome: R-HSA-75953;Reactome: R-HSA-6803529;Reactome: R-HSA-167242;Reactome: R-HSA-168325;Reactome: R-HSA-6807505;Reactome: R-HSA-167246	"RNA Polymerase II Promoter Escape";"mRNA Capping";"mRNA Splicing - Major Pathway";"MicroRNA (miRNA) biogenesis";"Pausing and recovery of HIV elongation";"Formation of TC-NER Pre-Incision Complex";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Transcriptional regulation by small RNAs";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"Processing of Capped Intron-Containing Pre-mRNA";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"PIWI-interacting RNA (piRNA) biogenesis";"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"mRNA Splicing - Minor Pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase II Transcription Initiation";"FGFR2 alternative splicing";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Viral Messenger RNA Synthesis";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript"
XP_053967704.1	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053952373.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053952925.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053968252.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_053962394.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053966274.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053961041.1	4	MetaCyc: PWY-5912;MetaCyc: PWY-5041;KEGG: 00270+2.5.1.6;Reactome: R-HSA-156581	"2'-deoxymugineic acid phytosiderophore biosynthesis";"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism";"Methylation"
XP_053963092.1	5	MetaCyc: PWY-7269;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_053959551.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053953704.1	5	Reactome: R-HSA-936964;Reactome: R-HSA-937072;Reactome: R-HSA-937041;Reactome: R-HSA-168164;Reactome: R-HSA-166166	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IKK complex recruitment mediated by RIP1";"Toll Like Receptor 3 (TLR3) Cascade";"MyD88-independent TLR4 cascade"
XP_053959639.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053957515.1	14	KEGG: 00564+2.3.1.51;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;MetaCyc: PWY-7411;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;MetaCyc: PWY-6453;MetaCyc: PWY-7589;MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51	"Glycerophospholipid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Plasmalogen biosynthesis";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism"
XP_053949040.1	3	KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596	"Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I"
XP_053970194.1	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
XP_053946372.1	9	Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-73779	"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
XP_053950132.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_053957876.1	1	Reactome: R-HSA-2142789	"Ubiquinol biosynthesis"
XP_053955994.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053952367.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053952382.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053966390.1	9	Reactome: R-HSA-3371599;KEGG: 00020+6.4.1.1;MetaCyc: PWY-8086;Reactome: R-HSA-70263;Reactome: R-HSA-196780;KEGG: 00720+6.4.1.1;MetaCyc: PWY-6142;KEGG: 00620+6.4.1.1;MetaCyc: PWY-6146	"Defective HLCS causes multiple carboxylase deficiency";"Citrate cycle (TCA cycle)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis";"Biotin transport and metabolism";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pyruvate metabolism";"Methanobacterium thermoautotrophicum biosynthetic metabolism"
XP_053950161.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053962663.1	1	Reactome: R-HSA-419771	"Opsins"
XP_053965989.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_053968030.1	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
XP_053965518.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053963555.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053959017.1	5	KEGG: 00220+1.14.13.39;KEGG: 00330+1.14.13.39;Reactome: R-HSA-1222556;Reactome: R-HSA-392154;MetaCyc: PWY-4983	"Arginine biosynthesis";"Arginine and proline metabolism";"ROS and RNS production in phagocytes";"Nitric oxide stimulates guanylate cyclase";"Nitric oxide biosynthesis II (mammals)"
XP_053953757.1	3	KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783;MetaCyc: PWY-3961	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II"
XP_053947450.1	8	Reactome: R-HSA-912446;Reactome: R-HSA-5693616;Reactome: R-HSA-5685938;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-8953750	"Meiotic recombination";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Single Strand Annealing (SSA)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Transcriptional Regulation by E2F6"
XP_053952225.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_053964928.1	1	Reactome: R-HSA-6803204	"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"
XP_053967375.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053947115.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_053949151.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053967872.1	4	Reactome: R-HSA-2122947;Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-4641265	"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes"
XP_053969374.1	2	Reactome: R-HSA-203615;Reactome: R-HSA-8981607	"eNOS activation";"Intracellular oxygen transport"
XP_053967879.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053967701.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053949983.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_053958916.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_053953096.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053959781.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_053956460.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053945381.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053958256.1	5	Reactome: R-HSA-5610787;Reactome: R-HSA-5635838;Reactome: R-HSA-5632684;Reactome: R-HSA-373080;Reactome: R-HSA-5620922	"Hedgehog 'off' state";"Activation of SMO";"Hedgehog 'on' state";"Class B/2 (Secretin family receptors)";"BBSome-mediated cargo-targeting to cilium"
XP_053962003.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053955986.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053969535.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_053948646.1	2	Reactome: R-HSA-8854518;Reactome: R-HSA-6804756	"AURKA Activation by TPX2";"Regulation of TP53 Activity through Phosphorylation"
XP_053959737.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053962042.1	8	Reactome: R-HSA-5628897;Reactome: R-HSA-9613354;Reactome: R-HSA-1632852;Reactome: R-HSA-2151209;Reactome: R-HSA-9619483;Reactome: R-HSA-6804756;Reactome: R-HSA-380972;Reactome: R-HSA-1445148	"TP53 Regulates Metabolic Genes";"Lipophagy";"Macroautophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Activation of AMPK downstream of NMDARs";"Regulation of TP53 Activity through Phosphorylation";"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053964139.1	17	Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-6790901;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72649	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"rRNA modification in the nucleus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation"
XP_053959514.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053961633.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053956945.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053962386.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053945431.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053959849.1	4	Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-419037	"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"NCAM1 interactions"
XP_053957344.1	5	Reactome: R-HSA-109704;Reactome: R-HSA-1257604;Reactome: R-HSA-6811558;Reactome: R-HSA-2219530;Reactome: R-HSA-5673001	"PI3K Cascade";"PIP3 activates AKT signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"RAF/MAP kinase cascade"
XP_053951396.1	5	Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-9615710;Reactome: R-HSA-917729	"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Budding and maturation of HIV virion";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)"
XP_053959507.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053948417.1	1	Reactome: R-HSA-416476	"G alpha (q) signalling events"
XP_053950164.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_053959664.1	20	MetaCyc: PWY-6837;MetaCyc: PWY-7291;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-7858;MetaCyc: PWY-7338;MetaCyc: PWY-7007;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7288;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7854;MetaCyc: PWY-5136;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-6920;MetaCyc: PWY-7340;MetaCyc: PWY-7726	"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(5Z)-dodecenoate biosynthesis II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Methyl ketone biosynthesis (engineered)";"beta-Alanine metabolism";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Fatty acid degradation";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"Peroxisomal protein import";"6-gingerol analog biosynthesis (engineered)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"
XP_053961305.1	3	Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-73856	"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination"
XP_053958216.1	2	Reactome: R-HSA-5663220;Reactome: R-HSA-376176	"RHO GTPases Activate Formins";"Signaling by ROBO receptors"
XP_053949979.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053953081.1	3	Reactome: R-HSA-3065678;Reactome: R-HSA-983168;Reactome: R-HSA-3065676	"SUMO is transferred from E1 to E2 (UBE2I, UBC9)";"Antigen processing: Ubiquitination & Proteasome degradation";"SUMO is conjugated to E1 (UBA2:SAE1)"
XP_053947166.1	9	MetaCyc: PWY-7411;MetaCyc: PWY-7902;MetaCyc: PWY-5981;Reactome: R-HSA-1483166;KEGG: 00564+1.1.1.8;KEGG: 00564+1.1.1.94;MetaCyc: PWY-7385;MetaCyc: PWY-6118;MetaCyc: PWY-5667	"Phosphatidate biosynthesis (yeast)";"Glucosylglycerol biosynthesis";"CDP-diacylglycerol biosynthesis III";"Synthesis of PA";"Glycerophospholipid metabolism";"Glycerophospholipid metabolism";"1,3-propanediol biosynthesis (engineered)";"Glycerol-3-phosphate shuttle";"CDP-diacylglycerol biosynthesis I"
XP_053953037.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053951487.1	5	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-196025;Reactome: R-HSA-3928665;Reactome: R-HSA-190873	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells";"Gap junction degradation"
XP_053951462.1	14	Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-1632852;Reactome: R-HSA-3371497;Reactome: R-HSA-5620924;Reactome: R-HSA-141444;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878	"RHO GTPases Activate Formins";"HCMV Early Events";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"Mitotic Prometaphase";"Macroautophagy";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Intraflagellar transport";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport"
XP_053955286.1	5	KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2	"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Glyoxylate metabolism and glycine degradation";"Lysine degradation"
XP_053959554.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053951469.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053967659.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837	"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases"
XP_053967531.1	6	KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_053955991.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053970191.1	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
XP_053945469.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
XP_053961158.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053965788.1	15	Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-2559585;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-9029569	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"Oncogene Induced Senescence";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_053956468.1	3	KEGG: 04070+3.1.3.78;MetaCyc: PWY-6367;MetaCyc: PWY-6368	"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"3-phosphoinositide degradation"
XP_053961044.1	4	Reactome: R-HSA-156581;KEGG: 00270+2.5.1.6;MetaCyc: PWY-5912;MetaCyc: PWY-5041	"Methylation";"Cysteine and methionine metabolism";"2'-deoxymugineic acid phytosiderophore biosynthesis";"S-adenosyl-L-methionine cycle II"
XP_053952443.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053965750.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_053957715.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_053949578.1	3	Reactome: R-HSA-430039;Reactome: R-HSA-450385;Reactome: R-HSA-450513	"mRNA decay by 5' to 3' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_053964963.1	5	Reactome: R-HSA-1912399;Reactome: R-HSA-1912420;Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-5083630	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Pre-NOTCH Processing in Golgi";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"Defective LFNG causes SCDO3"
XP_053958286.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053967517.1	3	Reactome: R-HSA-2980766;Reactome: R-HSA-2995383;Reactome: R-HSA-4419969	"Nuclear Envelope Breakdown";"Initiation of Nuclear Envelope Reformation";"Depolymerisation of the Nuclear Lamina"
XP_053952855.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053959475.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053952198.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_053961839.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053948462.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_053948487.1	16	Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-174084;Reactome: R-HSA-174184;Reactome: R-HSA-176407;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-141430;Reactome: R-HSA-8853884;Reactome: R-HSA-2467813;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-176408;Reactome: R-HSA-174048	"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Transcriptional Regulation by VENTX";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B"
XP_053962628.1	13	KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;MetaCyc: PWY-7822;KEGG: 00603+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;KEGG: 00511+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52	"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Chitin degradation III (Serratia)";"Glycosphingolipid biosynthesis - globo and isoglobo series";"CS/DS degradation";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Other glycan degradation";"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
XP_053948469.1	11	MetaCyc: PWY-6964;KEGG: 00630+6.3.1.2;MetaCyc: PWY-5675;Reactome: R-HSA-210455;KEGG: 00250+6.3.1.2;MetaCyc: PWY-381;Reactome: R-HSA-8964539;KEGG: 00910+6.3.1.2;MetaCyc: PWY-6963;KEGG: 00220+6.3.1.2;MetaCyc: PWY-6549	"Ammonia assimilation cycle II";"Glyoxylate and dicarboxylate metabolism";"Nitrate reduction V (assimilatory)";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Alanine, aspartate and glutamate metabolism";"Nitrate reduction II (assimilatory)";"Glutamate and glutamine metabolism";"Nitrogen metabolism";"Ammonia assimilation cycle I";"Arginine biosynthesis";"L-glutamine biosynthesis III"
XP_053961832.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053952866.1	10	Reactome: R-HSA-70370;MetaCyc: PWY-7328;MetaCyc: PWY-6397;Reactome: R-HSA-5609977;MetaCyc: PWY-7344;MetaCyc: PWY-6527;KEGG: 00052+5.1.3.2;MetaCyc: PWY-3821;MetaCyc: PWY-6317;KEGG: 00520+5.1.3.2	"Galactose catabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"UDP-alpha-D-galactose biosynthesis";"Stachyose degradation";"Galactose metabolism";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism"
XP_053970165.1	57	Reactome: R-HSA-382556;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-4608870;Reactome: R-HSA-180534;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-6798695;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-174184;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751	"ABC-family proteins mediated transport";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Asymmetric localization of PCP proteins";"Vpu mediated degradation of CD4";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neutrophil degranulation";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Degradation of DVL";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity"
XP_053966173.1	1	Reactome: R-HSA-427413	"NoRC negatively regulates rRNA expression"
XP_053953853.1	3	Reactome: R-HSA-110320;Reactome: R-HSA-5656169;Reactome: R-HSA-5685942	"Translesion Synthesis by POLH";"Termination of translesion DNA synthesis";"HDR through Homologous Recombination (HRR)"
XP_053961861.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053969015.1	16	Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459;Reactome: R-HSA-8934593;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-1912408	"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX1 Expression and Activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"Pre-NOTCH Transcription and Translation"
XP_053968008.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport"
XP_053949137.1	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
XP_053953268.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053970156.1	6	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition"
XP_053963694.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053949860.1	2	Reactome: R-HSA-201681;Reactome: R-HSA-3772470	"TCF dependent signaling in response to WNT";"Negative regulation of TCF-dependent signaling by WNT ligand antagonists"
XP_053948396.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;Reactome: R-HSA-114508	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Effects of PIP2 hydrolysis"
XP_053953673.1	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
XP_053953260.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053964858.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053953051.1	2	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"COPI-mediated anterograde transport"
XP_053959711.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053961063.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_053954106.1	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
XP_053969592.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053950529.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053964977.1	10	Reactome: R-HSA-9022692;Reactome: R-HSA-3899300;Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-9022699;Reactome: R-HSA-9022538;Reactome: R-HSA-983231;Reactome: R-HSA-427413	"Regulation of MECP2 expression and activity";"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression"
XP_053962316.1	1	Reactome: R-HSA-1483255	"PI Metabolism"
XP_053946442.1	22	Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-5663220;Reactome: R-HSA-195253;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5358751;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-6811558;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-2500257;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-5673000	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"RHO GTPases Activate Formins";"Degradation of beta-catenin by the destruction complex";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RAF activation"
XP_053955265.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_053953734.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053967504.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_053962641.1	1	Reactome: R-HSA-212300	"PRC2 methylates histones and DNA"
XP_053965758.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_053969347.1	3	Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154	"Smooth Muscle Contraction";"Purine metabolism";"Nitric oxide stimulates guanylate cyclase"
XP_053946403.1	9	MetaCyc: PWY-241;MetaCyc: PWY-5744;Reactome: R-HSA-1475029;MetaCyc: PWY-7117;MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-5789;KEGG: 00910+4.2.1.1;MetaCyc: PWY-6142	"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Glyoxylate assimilation";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Nitrogen metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
XP_053959602.1	2	Reactome: R-HSA-68962;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress"
XP_053964810.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053955256.1	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_053946586.1	1	Reactome: R-HSA-1169408	"ISG15 antiviral mechanism"
XP_053954526.1	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
XP_053951545.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053965623.1	1	Reactome: R-HSA-9617828	"FOXO-mediated transcription of cell cycle genes"
XP_053951457.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053967682.1	4	Reactome: R-HSA-9646399;Reactome: R-HSA-9613829;Reactome: R-HSA-3899300;Reactome: R-HSA-9615710	"Aggrephagy";"Chaperone Mediated Autophagy";"SUMOylation of transcription cofactors";"Late endosomal microautophagy"
XP_053966182.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_053962620.1	3	Reactome: R-HSA-110312;Reactome: R-HSA-5655862;Reactome: R-HSA-5656121	"Translesion synthesis by REV1";"Translesion synthesis by POLK";"Translesion synthesis by POLI"
XP_053968780.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_053967689.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053966937.1	5	KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253;Reactome: R-HSA-3656237;MetaCyc: PWY-6558	"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective EXT2 causes exostoses 2";"Heparan sulfate biosynthesis (late stages)"
XP_053965823.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053960098.1	1	Reactome: R-HSA-8964038	"LDL clearance"
XP_053961345.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053957304.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053964610.1	2	KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10	"Glycine, serine and threonine metabolism";"One carbon pool by folate"
XP_053945371.1	3	Reactome: R-HSA-2299718;Reactome: R-HSA-6804760;Reactome: R-HSA-3214841	"Condensation of Prophase Chromosomes";"Regulation of TP53 Activity through Methylation";"PKMTs methylate histone lysines"
XP_053962841.1	27	Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-168333;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-3301854;Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-180910	"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"Vpr-mediated nuclear import of PICs"
XP_053952875.1	3	KEGG: 00350+3.7.1.2;Reactome: R-HSA-8963684;KEGG: 00643+3.7.1.2	"Tyrosine metabolism";"Tyrosine catabolism";"Styrene degradation"
XP_053963926.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053949282.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053959809.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053950901.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053960329.1	10	Reactome: R-HSA-6804756;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-3214847;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776	"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"HATs acetylate histones";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape"
XP_053966824.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053961004.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_053953720.1	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
XP_053955976.1	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
XP_053946885.1	5	KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7922;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109	"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis"
XP_053951463.1	14	Reactome: R-HSA-1632852;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-5620924;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295	"Macroautophagy";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"Intraflagellar transport";"RHO GTPases Activate Formins";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation"
XP_053945846.1	5	Reactome: R-HSA-1632852;Reactome: R-HSA-165181;Reactome: R-HSA-5628897;Reactome: R-HSA-8854214;Reactome: R-HSA-380972	"Macroautophagy";"Inhibition of TSC complex formation by PKB";"TP53 Regulates Metabolic Genes";"TBC/RABGAPs";"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_053949510.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053948735.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_053964870.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053966296.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_053962789.1	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange"
XP_053953728.1	4	Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-9010553	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs"
XP_053962767.1	17	Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-6804756;Reactome: R-HSA-5693568;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-2559586;Reactome: R-HSA-5685939;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-912446;Reactome: R-HSA-5685942;Reactome: R-HSA-5693548;Reactome: R-HSA-3270619;Reactome: R-HSA-5693554;Reactome: R-HSA-1834949	"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"DNA Damage/Telomere Stress Induced Senescence";"HDR through MMEJ (alt-NHEJ)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Meiotic recombination";"HDR through Homologous Recombination (HRR)";"Sensing of DNA Double Strand Breaks";"IRF3-mediated induction of type I IFN";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Cytosolic sensors of pathogen-associated DNA"
XP_053947321.1	4	Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination"
XP_053964878.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053949989.1	5	Reactome: R-HSA-6804757;Reactome: R-HSA-389357;Reactome: R-HSA-1257604;Reactome: R-HSA-5218920;Reactome: R-HSA-5674400	"Regulation of TP53 Degradation";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling";"VEGFR2 mediated vascular permeability";"Constitutive Signaling by AKT1 E17K in Cancer"
XP_053949518.1	11	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-2559580;Reactome: R-HSA-450302;Reactome: R-HSA-4420097	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"p38MAPK events";"Oxidative Stress Induced Senescence";"activated TAK1 mediates p38 MAPK activation";"VEGFA-VEGFR2 Pathway"
XP_053964650.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-111367	"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"SLBP independent Processing of Histone Pre-mRNAs"
XP_053965114.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053953653.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
XP_053949967.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053949982.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_053956905.1	25	Reactome: R-HSA-8939242;Reactome: R-HSA-8941284;Reactome: R-HSA-8951911;Reactome: R-HSA-8878166;Reactome: R-HSA-8939902;Reactome: R-HSA-8939246;Reactome: R-HSA-8941326;Reactome: R-HSA-8939247;Reactome: R-HSA-8936459;Reactome: R-HSA-8939243;Reactome: R-HSA-8877330;Reactome: R-HSA-8941858;Reactome: R-HSA-8931987;Reactome: R-HSA-8941333;Reactome: R-HSA-8951936;Reactome: R-HSA-8940973;Reactome: R-HSA-8939245;Reactome: R-HSA-8941332;Reactome: R-HSA-8949275;Reactome: R-HSA-8934593;Reactome: R-HSA-8939256;Reactome: R-HSA-9018519;Reactome: R-HSA-8935964;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222	"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX2 regulates chondrocyte maturation";"RUNX3 regulates RUNX1-mediated transcription";"Transcriptional regulation by RUNX2";"Regulation of RUNX2 expression and activity";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX2 regulates bone development";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"Regulation of RUNX3 expression and activity";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX3 regulates p14-ARF";"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX2 regulates genes involved in cell migration";"RUNX3 Regulates Immune Response and Cell Migration";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates transcription of genes involved in WNT signaling";"Estrogen-dependent gene expression";"RUNX1 regulates expression of components of tight junctions";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis"
XP_053948125.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053961632.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053950201.1	10	Reactome: R-HSA-6804756;Reactome: R-HSA-8948751;Reactome: R-HSA-1483191;Reactome: R-HSA-6798695;Reactome: R-HSA-2514853;Reactome: R-HSA-201688;Reactome: R-HSA-445144;Reactome: R-HSA-8934903;Reactome: R-HSA-6814122;Reactome: R-HSA-8939243	"Regulation of TP53 Activity through Phosphorylation";"Regulation of PTEN stability and activity";"Synthesis of PC";"Neutrophil degranulation";"Condensation of Prometaphase Chromosomes";"WNT mediated activation of DVL";"Signal transduction by L1";"Receptor Mediated Mitophagy";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053962828.1	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
XP_053961551.1	6	Reactome: R-HSA-8957275;Reactome: R-HSA-3769402;Reactome: R-HSA-5626467;Reactome: R-HSA-2173796;Reactome: R-HSA-201722;Reactome: R-HSA-381426	"Post-translational protein phosphorylation";"Deactivation of the beta-catenin transactivating complex";"RHO GTPases activate IQGAPs";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of the beta-catenin:TCF transactivating complex";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
XP_053964560.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053961639.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053957317.1	16	Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-2467813;Reactome: R-HSA-176412;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-174084;Reactome: R-HSA-174184	"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Separation of Sister Chromatids";"Phosphorylation of the APC/C";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
XP_053962002.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_053966068.1	6	KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_053969897.1	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
XP_053968021.1	2	Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
XP_053961754.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053966426.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053952591.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053945125.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72649	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation"
XP_053951606.1	17	MetaCyc: PWY-7220;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7222;MetaCyc: PWY-7221;MetaCyc: PWY-7198;MetaCyc: PWY-7205;MetaCyc: PWY-7176;MetaCyc: PWY-7227;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7224;MetaCyc: PWY-7210;KEGG: 00230+2.7.4.6;MetaCyc: PWY-6545;MetaCyc: PWY-7197;MetaCyc: PWY-7226;MetaCyc: PWY-7184;MetaCyc: PWY-7187	"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"CMP phosphorylation";"UTP and CTP de novo biosynthesis";"Adenosine deoxyribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotide phosphorylation";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II"
XP_053951125.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053961087.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053948477.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053969354.1	3	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-6807505	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes"
XP_053955192.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_053964688.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053961707.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053967683.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053965622.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
XP_053963481.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053960915.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_053966183.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053955199.1	3	Reactome: R-HSA-430039;Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_053957387.1	1	Reactome: R-HSA-196783	"Coenzyme A biosynthesis"
XP_053946866.1	9	Reactome: R-HSA-110330;Reactome: R-HSA-110328;Reactome: R-HSA-9630221;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-9608287;Reactome: R-HSA-9608290;Reactome: R-HSA-110357;Reactome: R-HSA-9630222	"Recognition and association of DNA glycosylase with site containing an affected purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective NTHL1 substrate processing";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Defective MUTYH substrate binding";"Defective MUTYH substrate processing";"Displacement of DNA glycosylase by APEX1";"Defective NTHL1 substrate binding"
XP_053962601.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053946443.1	22	Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-2500257;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-68877;Reactome: R-HSA-5358751;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-6811558	"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"Beta-catenin phosphorylation cascade";"RAF activation";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
XP_053959603.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053946402.1	5	KEGG: 00983+2.4.2.3;Reactome: R-HSA-73614;Reactome: R-HSA-73621;KEGG: 00240+2.4.2.3;MetaCyc: PWY-5532	"Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine catabolism";"Pyrimidine metabolism";"Nucleoside and nucleotide degradation (archaea)"
XP_053950103.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053953812.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053949959.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053963387.1	6	Reactome: R-HSA-72187;Reactome: R-HSA-975957;Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-9010553	"mRNA 3'-end processing";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"Regulation of expression of SLITs and ROBOs"
XP_053949212.1	14	MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7619;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-7036	"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II"
XP_053946190.1	6	Reactome: R-HSA-427359;Reactome: R-HSA-427413;Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-73762	"SIRT1 negatively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation"
XP_053948792.1	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_053962064.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053953683.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053952442.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053947175.1	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
XP_053949038.1	3	KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596;Reactome: R-HSA-74217	"Purine metabolism";"Adenosine nucleotides degradation I";"Purine salvage"
XP_053955400.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053968107.1	6	Reactome: R-HSA-2046105;Reactome: R-HSA-390247;Reactome: R-HSA-9603798;Reactome: R-HSA-5684045;Reactome: R-HSA-1369062;Reactome: R-HSA-2046106	"Linoleic acid (LA) metabolism";"Beta-oxidation of very long chain fatty acids";"Class I peroxisomal membrane protein import";"Defective ABCD1 causes adrenoleukodystrophy (ALD)";"ABC transporters in lipid homeostasis";"alpha-linolenic acid (ALA) metabolism"
XP_053953544.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053946675.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053964931.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053966060.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_053957437.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053967679.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_053966172.1	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"Intra-Golgi traffic"
XP_053961581.1	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
XP_053948371.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
XP_053952756.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053957575.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053957816.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053948298.1	16	Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956	"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_053962446.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_053965137.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053958430.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053963484.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053952353.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053959832.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053955350.1	3	KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067;Reactome: R-HSA-3322077	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen synthesis"
XP_053949174.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053950987.1	8	Reactome: R-HSA-5340588;Reactome: R-HSA-373080;Reactome: R-HSA-4086398;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-4608870;Reactome: R-HSA-4641263;Reactome: R-HSA-5099900	"RNF mutants show enhanced WNT signaling and proliferation";"Class B/2 (Secretin family receptors)";"Ca2+ pathway";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Asymmetric localization of PCP proteins";"Regulation of FZD by ubiquitination";"WNT5A-dependent internalization of FZD4"
XP_053969351.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_053963856.1	14	MetaCyc: PWY-8052;MetaCyc: PWY-8055;Reactome: R-HSA-4419969;MetaCyc: PWY-8051;Reactome: R-HSA-1483191;KEGG: 00564+3.1.3.4;Reactome: R-HSA-75109;KEGG: 00561+3.1.3.4;Reactome: R-HSA-1483213;MetaCyc: PWY-8053;KEGG: 00565+3.1.3.4;MetaCyc: PWY-6453;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4	"2-arachidonoylglycerol biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Depolymerisation of the Nuclear Lamina";"Anandamide biosynthesis I";"Synthesis of PC";"Glycerophospholipid metabolism";"Triglyceride biosynthesis";"Glycerolipid metabolism";"Synthesis of PE";"Anandamide biosynthesis II";"Ether lipid metabolism";"Stigma estolide biosynthesis";"Plasmalogen biosynthesis";"Sphingolipid metabolism"
XP_053967315.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053951441.1	3	MetaCyc: PWY-7807;MetaCyc: PWY-7805;KEGG: 00190+3.6.1.1	"Glyphosate degradation III";"(aminomethyl)phosphonate degradation";"Oxidative phosphorylation"
XP_053962950.1	3	Reactome: R-HSA-426048;MetaCyc: PWY-7420;KEGG: 00561+3.1.1.23	"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)";"Glycerolipid metabolism"
XP_053962210.1	18	MetaCyc: PWY-7197;MetaCyc: PWY-7226;KEGG: 00230+2.7.4.6;Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7184;MetaCyc: PWY-7187;MetaCyc: PWY-7198;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7220;MetaCyc: PWY-7221;MetaCyc: PWY-7222;MetaCyc: PWY-7227;MetaCyc: PWY-7176;MetaCyc: PWY-7224;MetaCyc: PWY-7210;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7205	"Pyrimidine deoxyribonucleotide phosphorylation";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine ribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"UTP and CTP de novo biosynthesis";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes";"CMP phosphorylation"
XP_053964760.1	7	KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053968024.1	2	Reactome: R-HSA-201722;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex"
XP_053953100.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053962032.1	13	Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits"
XP_053967108.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053952716.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053966608.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_053969545.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053948374.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_053948998.1	14	MetaCyc: PWY-3841;MetaCyc: PWY-1622;KEGG: 00460+2.1.2.1;MetaCyc: PWY-2201;KEGG: 00630+2.1.2.1;KEGG: 00260+2.1.2.1;KEGG: 00670+2.1.2.1;MetaCyc: PWY-3661;MetaCyc: PWY-181;Reactome: R-HSA-196757;MetaCyc: PWY-5497;MetaCyc: PWY-3661-1;KEGG: 00680+2.1.2.1;MetaCyc: PWY-2161	"Folate transformations II (plants)";"Formaldehyde assimilation I (serine pathway)";"Cyanoamino acid metabolism";"Folate transformations I";"Glyoxylate and dicarboxylate metabolism";"Glycine, serine and threonine metabolism";"One carbon pool by folate";"Glycine betaine degradation I";"Photorespiration ";"Metabolism of folate and pterines";"Purine nucleobases degradation II (anaerobic)";"Glycine betaine degradation II (mammalian)";"Methane metabolism";"Folate polyglutamylation"
XP_053951428.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053961584.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053962039.1	6	Reactome: R-HSA-76005;Reactome: R-HSA-418597;Reactome: R-HSA-416993;Reactome: R-HSA-5099900;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114516	"Response to elevated platelet cytosolic Ca2+";"G alpha (z) signalling events";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD4";"Phosphatidylinositol signaling system";"Disinhibition of SNARE formation"
XP_053950231.1	26	Reactome: R-HSA-8866907;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-918233;Reactome: R-HSA-933541;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-9614657;Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-9617629;Reactome: R-HSA-3371568;Reactome: R-HSA-3134973;Reactome: R-HSA-400253;Reactome: R-HSA-3899300;Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-5621575;Reactome: R-HSA-9013508;Reactome: R-HSA-1368082;Reactome: R-HSA-1234158	"Activation of the TFAP2 (AP-2) family of transcription factors";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"TRAF3-dependent IRF activation pathway";"TRAF6 mediated IRF7 activation";"PPARA activates gene expression";"Estrogen-dependent gene expression";"FOXO-mediated transcription of cell death genes";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"Attenuation phase";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Circadian Clock";"SUMOylation of transcription cofactors";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"CD209 (DC-SIGN) signaling";"NOTCH3 Intracellular Domain Regulates Transcription";"RORA activates gene expression";"Regulation of gene expression by Hypoxia-inducible Factor"
XP_053951055.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_053967499.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_053955525.1	4	KEGG: 00590+5.3.99.3;Reactome: R-HSA-499943;Reactome: R-HSA-6798695;Reactome: R-HSA-2162123	"Arachidonic acid metabolism";"Interconversion of nucleotide di- and triphosphates";"Neutrophil degranulation";"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
XP_053961643.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053954255.1	13	MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-5913;MetaCyc: PWY-7384;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-6969;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-5537	"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"C5-Branched dibasic acid metabolism";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Pyruvate fermentation to acetate V"
XP_053962958.1	3	KEGG: 00561+3.1.1.23;MetaCyc: PWY-7420;Reactome: R-HSA-426048	"Glycerolipid metabolism";"Monoacylglycerol metabolism (yeast)";"Arachidonate production from DAG"
XP_053951599.1	1	Reactome: R-HSA-419037	"NCAM1 interactions"
XP_053969404.1	5	Reactome: R-HSA-201681;Reactome: R-HSA-5545619;Reactome: R-HSA-4641257;Reactome: R-HSA-5689880;Reactome: R-HSA-8948751	"TCF dependent signaling in response to WNT";"XAV939 inhibits tankyrase, stabilizing AXIN";"Degradation of AXIN";"Ub-specific processing proteases";"Regulation of PTEN stability and activity"
XP_053953777.1	2	KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386	"Pyruvate metabolism";"Methylglyoxal degradation I"
XP_053947470.1	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_053948290.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_053967355.1	5	MetaCyc: PWY-7766;MetaCyc: PWY-5531;KEGG: 00860+4.1.1.37;Reactome: R-HSA-189451;MetaCyc: PWY-7159	"Heme b biosynthesis IV (Gram-positive bacteria)";"3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"
XP_053948535.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053950287.1	10	MetaCyc: PWY-7112;MetaCyc: PWY-7559;MetaCyc: PWY-5826;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-6842;KEGG: 00430+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13	"4-hydroxy-2-nonenal detoxification";"Glutathione degradation (DUG pathway";"Hypoglycin biosynthesis";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Glutathione-mediated detoxification II";"Taurine and hypotaurine metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Glutathione metabolism"
XP_053953541.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053956598.1	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
XP_053945592.1	8	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"Signaling by Hippo";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053959063.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
XP_053965868.1	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
XP_053967528.1	6	MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884	"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I"
XP_053962061.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053965196.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_053964523.1	13	Reactome: R-HSA-5607764;Reactome: R-HSA-450321;Reactome: R-HSA-937042;Reactome: R-HSA-9645460;Reactome: R-HSA-445989;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-2871837;Reactome: R-HSA-9020702;Reactome: R-HSA-937072;Reactome: R-HSA-9014325;Reactome: R-HSA-450302;Reactome: R-HSA-975163	"CLEC7A (Dectin-1) signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex";"Alpha-protein kinase 1 signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"FCERI mediated NF-kB activation";"Interleukin-1 signaling";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TICAM1,TRAF6-dependent induction of TAK1 complex";"activated TAK1 mediates p38 MAPK activation";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"
XP_053953744.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053950133.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053962288.1	5	Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-5628897;Reactome: R-HSA-75035;Reactome: R-HSA-5625740	"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"TP53 Regulates Metabolic Genes";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs"
XP_053945290.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053946373.1	9	Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-6804756	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation"
XP_053959633.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053946925.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053949000.1	14	MetaCyc: PWY-1622;MetaCyc: PWY-3841;KEGG: 00460+2.1.2.1;MetaCyc: PWY-2201;KEGG: 00630+2.1.2.1;KEGG: 00260+2.1.2.1;KEGG: 00670+2.1.2.1;MetaCyc: PWY-3661;Reactome: R-HSA-196757;MetaCyc: PWY-181;MetaCyc: PWY-3661-1;MetaCyc: PWY-5497;KEGG: 00680+2.1.2.1;MetaCyc: PWY-2161	"Formaldehyde assimilation I (serine pathway)";"Folate transformations II (plants)";"Cyanoamino acid metabolism";"Folate transformations I";"Glyoxylate and dicarboxylate metabolism";"Glycine, serine and threonine metabolism";"One carbon pool by folate";"Glycine betaine degradation I";"Metabolism of folate and pterines";"Photorespiration ";"Glycine betaine degradation II (mammalian)";"Purine nucleobases degradation II (anaerobic)";"Methane metabolism";"Folate polyglutamylation"
XP_053958310.1	6	KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632;KEGG: 00512+2.4.1.122;MetaCyc: PWY-7433;Reactome: R-HSA-913709;MetaCyc: PWY-7290	"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Mucin type O-glycan biosynthesis";"Mucin core 1 and core 2 O-glycosylation";"O-linked glycosylation of mucins";"Escherichia coli serotype O86 O-antigen biosynthesis"
XP_053968253.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_053961001.1	5	KEGG: 00230+6.3.5.3;MetaCyc: PWY-6277;Reactome: R-HSA-73817;MetaCyc: PWY-6122;MetaCyc: PWY-6121	"Purine metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"5-aminoimidazole ribonucleotide biosynthesis I"
XP_053966821.1	8	Reactome: R-HSA-8953750;Reactome: R-HSA-111458;Reactome: R-HSA-111464;Reactome: R-HSA-111459;Reactome: R-HSA-6803207;Reactome: R-HSA-111463;Reactome: R-HSA-6798695;Reactome: R-HSA-9627069	"Transcriptional Regulation by E2F6";"Formation of apoptosome";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Activation of caspases through apoptosome-mediated cleavage";"TP53 Regulates Transcription of Caspase Activators and Caspases";"SMAC (DIABLO) binds to IAPs";"Neutrophil degranulation";"Regulation of the apoptosome activity"
XP_053950560.1	2	Reactome: R-HSA-3214815;Reactome: R-HSA-427413	"HDACs deacetylate histones";"NoRC negatively regulates rRNA expression"
XP_053952786.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053950904.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053953385.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_053962980.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053948347.1	1	Reactome: R-HSA-5617472	"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
XP_053958358.1	5	Reactome: R-HSA-879415;Reactome: R-HSA-8957275;Reactome: R-HSA-381426;Reactome: R-HSA-532668;Reactome: R-HSA-901042	"Advanced glycosylation endproduct receptor signaling";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Calnexin/calreticulin cycle"
XP_053956999.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053959774.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_053950878.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-1660661;Reactome: R-HSA-9609523	"Neutrophil degranulation";"Sphingolipid de novo biosynthesis";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_053952006.1	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
XP_053952383.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053949780.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_053946461.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053965279.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_053951998.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_053969381.1	2	Reactome: R-HSA-5683371;Reactome: R-HSA-1369007	"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)";"Mitochondrial ABC transporters"
XP_053948441.1	32	Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-72203;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-72163;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-77075;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167162;Reactome: R-HSA-167287;Reactome: R-HSA-6803529;Reactome: R-HSA-6807505;Reactome: R-HSA-167246;Reactome: R-HSA-167242;Reactome: R-HSA-168325;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-72165;Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-75953	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Major Pathway";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"RNA Polymerase II Promoter Escape";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape";"HIV elongation arrest and recovery";"FGFR2 alternative splicing";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Viral Messenger RNA Synthesis";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"mRNA Splicing - Minor Pathway";"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Initiation"
XP_053950870.1	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
XP_053961393.1	13	Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053949147.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-375276	"G alpha (i) signalling events";"Peptide ligand-binding receptors"
XP_053953435.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053958350.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053950658.1	2	Reactome: R-HSA-71336;KEGG: 00030+2.7.1.15	"Pentose phosphate pathway";"Pentose phosphate pathway"
XP_053961127.1	6	MetaCyc: PWY-6983;MetaCyc: PWY-5663;Reactome: R-HSA-1474151;MetaCyc: PWY-7442;MetaCyc: PWY-5664;KEGG: 00790+4.2.3.12	"Threo-tetrahydrobiopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Drosopterin and aurodrosopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis II";"Folate biosynthesis"
XP_053950204.1	7	Reactome: R-HSA-3371453;Reactome: R-HSA-381183;Reactome: R-HSA-381070;Reactome: R-HSA-381033;Reactome: R-HSA-114608;Reactome: R-HSA-983170;Reactome: R-HSA-381042	"Regulation of HSF1-mediated heat shock response";"ATF6 (ATF6-alpha) activates chaperone genes";"IRE1alpha activates chaperones";"ATF6 (ATF6-alpha) activates chaperones";"Platelet degranulation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"PERK regulates gene expression"
XP_053951990.1	2	Reactome: R-HSA-444821;Reactome: R-HSA-418555	"Relaxin receptors";"G alpha (s) signalling events"
XP_053969469.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-6791226	"Association of TriC/CCT with target proteins during biosynthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053945697.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053946367.1	4	KEGG: 00564+3.1.1.7;Reactome: R-HSA-112311;Reactome: R-HSA-1483191;Reactome: R-HSA-422085	"Glycerophospholipid metabolism";"Neurotransmitter clearance";"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin"
XP_053946382.1	5	Reactome: R-HSA-73621;Reactome: R-HSA-73614;KEGG: 00983+2.4.2.3;MetaCyc: PWY-5532;KEGG: 00240+2.4.2.3	"Pyrimidine catabolism";"Pyrimidine salvage";"Drug metabolism - other enzymes";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine metabolism"
XP_053961554.1	6	Reactome: R-HSA-2173796;Reactome: R-HSA-5626467;Reactome: R-HSA-8957275;Reactome: R-HSA-3769402;Reactome: R-HSA-381426;Reactome: R-HSA-201722	"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"RHO GTPases activate IQGAPs";"Post-translational protein phosphorylation";"Deactivation of the beta-catenin transactivating complex";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Formation of the beta-catenin:TCF transactivating complex"
XP_053945705.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053952379.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053962280.1	10	KEGG: 00010+2.7.1.11;KEGG: 00051+2.7.1.11;MetaCyc: PWY-7385;KEGG: 00052+2.7.1.11;MetaCyc: PWY-1042;KEGG: 00030+2.7.1.11;MetaCyc: PWY-5484;Reactome: R-HSA-70171;MetaCyc: PWY-1861;KEGG: 00680+2.7.1.11	"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"1,3-propanediol biosynthesis (engineered)";"Galactose metabolism";"Glycolysis IV (plant cytosol)";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Methane metabolism"
XP_053959305.1	4	MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.32;KEGG: 00592+3.1.1.32	"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism"
XP_053952372.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053952433.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053966848.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053961664.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053950610.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_053949829.1	3	KEGG: 00220+3.5.1.14;Reactome: R-HSA-5579007;Reactome: R-HSA-5423646	"Arginine biosynthesis";"Defective ACY1 causes encephalopathy";"Aflatoxin activation and detoxification"
XP_053963891.1	8	Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7198;KEGG: 00240+2.7.4.9;MetaCyc: PWY-7197;MetaCyc: PWY-7187;MetaCyc: PWY-7184;MetaCyc: PWY-7210	"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP"
XP_053961842.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053950326.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053957093.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053949822.1	3	Reactome: R-HSA-5423646;Reactome: R-HSA-5579007;KEGG: 00220+3.5.1.14	"Aflatoxin activation and detoxification";"Defective ACY1 causes encephalopathy";"Arginine biosynthesis"
XP_053961849.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053950890.1	4	Reactome: R-HSA-77075;Reactome: R-HSA-167160;MetaCyc: PWY-7375;Reactome: R-HSA-72086	"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Mrna capping I";"mRNA Capping"
XP_053961432.1	6	Reactome: R-HSA-71403;KEGG: 00630+4.2.1.3;KEGG: 00020+4.2.1.3;Reactome: R-HSA-1268020;KEGG: 00720+4.2.1.3;KEGG: 00290+4.2.1.33	"Citric acid cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism";"Citrate cycle (TCA cycle)";"Mitochondrial protein import";"Carbon fixation pathways in prokaryotes";"Valine, leucine and isoleucine biosynthesis"
XP_053961925.1	13	Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557	"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis"
XP_053948583.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053962384.1	13	MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-6859;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-7721;MetaCyc: PWY-7709;MetaCyc: PWY-7182;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-5123	"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis";"All-trans-farnesol biosynthesis";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Methyl phomopsenoate biosynthesis";"(3R)-linalool biosynthesis";"Linalool biosynthesis I";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis"
XP_053952028.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053945970.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_053969841.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053955984.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053945677.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053952455.1	15	Reactome: R-HSA-912446;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5693548;Reactome: R-HSA-5685942;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-5693565;Reactome: R-HSA-5693568;Reactome: R-HSA-2559586;Reactome: R-HSA-5685939	"Meiotic recombination";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Sensing of DNA Double Strand Breaks";"HDR through Homologous Recombination (HRR)";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Resolution of D-loop Structures through Holliday Junction Intermediates";"DNA Damage/Telomere Stress Induced Senescence";"HDR through MMEJ (alt-NHEJ)"
XP_053970184.1	2	Reactome: R-HSA-190873;Reactome: R-HSA-399719	"Gap junction degradation";"Trafficking of AMPA receptors"
XP_053955840.1	4	MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;MetaCyc: PWY-6855	"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)"
XP_053959516.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_053952771.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_053946781.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053960942.1	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
XP_053953094.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053958914.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_053958608.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053969376.1	2	Reactome: R-HSA-8981607;Reactome: R-HSA-203615	"Intracellular oxygen transport";"eNOS activation"
XP_053954740.1	57	Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-180534;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-6798695;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-4608870;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-68827	"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"Neddylation";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Vpu mediated degradation of CD4";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neutrophil degranulation";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Asymmetric localization of PCP proteins";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex"
XP_053945513.1	7	Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2660826;Reactome: R-HSA-2691232;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-2894862	"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053963702.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_053951278.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_053961461.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053950300.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053964450.1	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
XP_053947941.1	18	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-166208;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-6790901	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mTORC1-mediated signalling";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"rRNA modification in the nucleus and cytosol"
XP_053964246.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053946127.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_053966388.1	9	KEGG: 00620+6.4.1.1;KEGG: 00720+6.4.1.1;MetaCyc: PWY-6142;MetaCyc: PWY-6146;KEGG: 00020+6.4.1.1;Reactome: R-HSA-3371599;MetaCyc: PWY-8086;Reactome: R-HSA-70263;Reactome: R-HSA-196780	"Pyruvate metabolism";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Methanobacterium thermoautotrophicum biosynthetic metabolism";"Citrate cycle (TCA cycle)";"Defective HLCS causes multiple carboxylase deficiency";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis";"Biotin transport and metabolism"
XP_053954162.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053956024.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053945663.1	4	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"DARPP-32 events";"T cell receptor signaling pathway"
XP_053949245.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_053946393.1	6	MetaCyc: PWY-5668;Reactome: R-HSA-1483148;MetaCyc: PWY-5269;Reactome: R-HSA-1483166;KEGG: 00564+2.7.8.5;MetaCyc: PWY-7817	"Cardiolipin biosynthesis I";"Synthesis of PG";"Cardiolipin biosynthesis II";"Synthesis of PA";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_053964458.1	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
XP_053948579.1	4	Reactome: R-HSA-216083;Reactome: R-HSA-2129379;Reactome: R-HSA-3000170;Reactome: R-HSA-3000178	"Integrin cell surface interactions";"Molecules associated with elastic fibres";"Syndecan interactions";"ECM proteoglycans"
XP_053946554.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-8964539	"Transcriptional activation of mitochondrial biogenesis";"Glutamate and glutamine metabolism"
XP_053955284.1	5	Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2	"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Citrate cycle (TCA cycle)"
XP_053967453.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053957743.1	2	Reactome: R-HSA-382556;Reactome: R-HSA-5678895	"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis"
XP_053954748.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053958214.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-5663220	"Signaling by ROBO receptors";"RHO GTPases Activate Formins"
XP_053945978.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053951553.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_053960242.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_053959666.1	20	MetaCyc: PWY-5136;MetaCyc: PWY-7854;MetaCyc: PWY-7574;MetaCyc: PWY-7337;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-7288;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6920;MetaCyc: PWY-7340;MetaCyc: PWY-7726;Reactome: R-HSA-9033241;MetaCyc: PWY-7338;MetaCyc: PWY-7858;MetaCyc: PWY-7007;MetaCyc: PWY-6837;MetaCyc: PWY-7291;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;KEGG: 00410+1.3.3.6	"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Fatty acid degradation";"6-gingerol analog biosynthesis (engineered)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Peroxisomal protein import";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"Methyl ketone biosynthesis (engineered)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"beta-Alanine metabolism"
XP_053947164.1	9	MetaCyc: PWY-7411;MetaCyc: PWY-7902;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;MetaCyc: PWY-7385;KEGG: 00564+1.1.1.94;KEGG: 00564+1.1.1.8;MetaCyc: PWY-6118;MetaCyc: PWY-5667	"Phosphatidate biosynthesis (yeast)";"Glucosylglycerol biosynthesis";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"1,3-propanediol biosynthesis (engineered)";"Glycerophospholipid metabolism";"Glycerophospholipid metabolism";"Glycerol-3-phosphate shuttle";"CDP-diacylglycerol biosynthesis I"
XP_053956979.1	2	Reactome: R-HSA-163841;KEGG: 00900+2.1.1.100	"Gamma carboxylation, hypusine formation and arylsulfatase activation";"Terpenoid backbone biosynthesis"
XP_053946796.1	5	Reactome: R-HSA-6781823;Reactome: R-HSA-72163;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135	"Formation of TC-NER Pre-Incision Complex";"mRNA Splicing - Major Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER"
XP_053950155.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_053946849.1	14	MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199	"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation"
XP_053957611.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053952041.1	5	Reactome: R-HSA-186763;Reactome: R-HSA-5218921;Reactome: R-HSA-8849471;Reactome: R-HSA-5658442;Reactome: R-HSA-3928662	"Downstream signal transduction";"VEGFR2 mediated cell proliferation";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases";"Regulation of RAS by GAPs";"EPHB-mediated forward signaling"
XP_053969043.1	5	KEGG: 00230+2.7.4.3;KEGG: 00230+2.7.4.10;MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3	"Purine metabolism";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism"
XP_053965299.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053957346.1	2	Reactome: R-HSA-446205;KEGG: 00500+2.4.1.15	"Synthesis of GDP-mannose";"Starch and sucrose metabolism"
XP_053952485.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053955954.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053963764.1	20	KEGG: 00410+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-7291;MetaCyc: PWY-7338;MetaCyc: PWY-7858;MetaCyc: PWY-7007;Reactome: R-HSA-9033241;MetaCyc: PWY-6920;MetaCyc: PWY-7726;MetaCyc: PWY-7340;MetaCyc: PWY-7288;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7574;MetaCyc: PWY-5136;MetaCyc: PWY-7854;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-7337	"beta-Alanine metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"Methyl ketone biosynthesis (engineered)";"Peroxisomal protein import";"6-gingerol analog biosynthesis (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Fatty acid degradation";"Propanoyl-coa degradation II";"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"10-cis-heptadecenoyl-CoA degradation (yeast)"
XP_053958023.1	3	KEGG: 00600+3.2.1.45;KEGG: 00511+3.2.1.45;Reactome: R-HSA-1660662	"Sphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid metabolism"
XP_053953126.1	4	MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32	"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism"
XP_053970048.1	4	MetaCyc: PWY-4261;KEGG: 00040+2.7.1.17;Reactome: R-HSA-5661270;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Pentose and glucuronate interconversions";"Formation of xylulose-5-phosphate";"Glycerolipid metabolism"
XP_053962897.1	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
XP_053948394.1	6	Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107	"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_053959591.1	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
XP_053960521.1	42	Reactome: R-HSA-2299718;Reactome: R-HSA-3214842;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-427413;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-9018519;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5334118;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-73728;Reactome: R-HSA-3214815	"Condensation of Prophase Chromosomes";"HDMs demethylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"NoRC negatively regulates rRNA expression";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Meiotic recombination";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Estrogen-dependent gene expression";"Packaging Of Telomere Ends";"Meiotic synapsis";"DNA methylation";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Opening";"HDACs deacetylate histones"
XP_053956860.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053957930.1	5	Reactome: R-HSA-2132295;Reactome: R-HSA-983170;Reactome: R-HSA-1655829;Reactome: R-HSA-5694530;Reactome: R-HSA-204005	"MHC class II antigen presentation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER";"COPII-mediated vesicle transport"
XP_053953605.1	3	MetaCyc: PWY-7999;KEGG: 00130+4.1.1.90;Reactome: R-HSA-159740	"Vitamin K-epoxide cycle";"Ubiquinone and other terpenoid-quinone biosynthesis";"Gamma-carboxylation of protein precursors"
XP_053967479.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053969712.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_053954117.1	1	Reactome: R-HSA-1483101	"Synthesis of PS"
XP_053966318.1	1	Reactome: R-HSA-427359	"SIRT1 negatively regulates rRNA expression"
XP_053969719.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053951579.1	7	Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-6811434;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
XP_053956213.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053953797.1	14	MetaCyc: PWY-6453;MetaCyc: PWY-7589;MetaCyc: PWY-5981;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-7411;MetaCyc: PWY-5667;MetaCyc: PWY-7417;MetaCyc: PWY-8053;KEGG: 00564+2.3.1.51;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7587;MetaCyc: PWY-8055;MetaCyc: PWY-8051	"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Synthesis of PA";"Plasmalogen biosynthesis";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I"
XP_053952864.1	10	MetaCyc: PWY-7328;Reactome: R-HSA-70370;MetaCyc: PWY-6397;Reactome: R-HSA-5609977;MetaCyc: PWY-6527;MetaCyc: PWY-3821;KEGG: 00052+5.1.3.2;MetaCyc: PWY-7344;MetaCyc: PWY-6317;KEGG: 00520+5.1.3.2	"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Galactose catabolism";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Stachyose degradation";"D-galactose detoxification";"Galactose metabolism";"UDP-alpha-D-galactose biosynthesis";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism"
XP_053960101.1	2	KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7	"Pyruvate metabolism";"Aminobenzoate degradation"
XP_053952642.1	4	Reactome: R-HSA-110312;Reactome: R-HSA-5655862;Reactome: R-HSA-5656169;Reactome: R-HSA-5656121	"Translesion synthesis by REV1";"Translesion synthesis by POLK";"Termination of translesion DNA synthesis";"Translesion synthesis by POLI"
XP_053961359.1	24	Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-5610783;Reactome: R-HSA-381676;Reactome: R-HSA-4420097;Reactome: R-HSA-163560;Reactome: R-HSA-432040;Reactome: R-HSA-442720;Reactome: R-HSA-422356;Reactome: R-HSA-5610780;Reactome: R-HSA-8853659;Reactome: R-HSA-5687128;Reactome: R-HSA-8963896;Reactome: R-HSA-5621575;Reactome: R-HSA-9010642;Reactome: R-HSA-5610785;Reactome: R-HSA-180024;Reactome: R-HSA-9634600;KEGG: 04150+2.7.11.11;Reactome: R-HSA-392517;Reactome: R-HSA-163358;Reactome: R-HSA-983231;Reactome: R-HSA-163615;Reactome: R-HSA-111931	"Hedgehog 'off' state";"PKA activation in glucagon signalling";"Degradation of GLI2 by the proteasome";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"VEGFA-VEGFR2 Pathway";"Triglyceride catabolism";"Vasopressin regulates renal water homeostasis via Aquaporins";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Regulation of insulin secretion";"Degradation of GLI1 by the proteasome";"RET signaling";"MAPK6/MAPK4 signaling";"HDL assembly";"CD209 (DC-SIGN) signaling";"ROBO receptors bind AKAP5";"GLI3 is processed to GLI3R by the proteasome";"DARPP-32 events";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"mTOR signaling pathway";"Rap1 signalling";"PKA-mediated phosphorylation of key metabolic factors";"Factors involved in megakaryocyte development and platelet production";"PKA activation";"PKA-mediated phosphorylation of CREB"
XP_053967483.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_053959586.1	11	MetaCyc: PWY-7184;MetaCyc: PWY-7187;KEGG: 00770+3.6.1.9;KEGG: 00500+3.6.1.9;MetaCyc: PWY-7206;MetaCyc: PWY-6545;KEGG: 00740+3.6.1.9;KEGG: 00230+3.6.1.9;KEGG: 00760+3.6.1.9;KEGG: 00240+3.6.1.9;MetaCyc: PWY-7821	"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pantothenate and CoA biosynthesis";"Starch and sucrose metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Riboflavin metabolism";"Purine metabolism";"Nicotinate and nicotinamide metabolism";"Pyrimidine metabolism";"Tunicamycin biosynthesis"
XP_053946584.1	1	Reactome: R-HSA-1169408	"ISG15 antiviral mechanism"
XP_053955254.1	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_053954524.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053970114.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053948278.1	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
XP_053947498.1	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway"
XP_053953736.1	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
XP_053962314.1	1	Reactome: R-HSA-1483255	"PI Metabolism"
XP_053947102.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053963019.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053945831.1	3	Reactome: R-HSA-1483213;KEGG: 00564+4.1.1.65;MetaCyc: PWY-5669	"Synthesis of PE";"Glycerophospholipid metabolism";"Phosphatidylserine and phosphatidylethanolamine biosynthesis I"
XP_053959449.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053969752.1	2	KEGG: 00270+3.1.3.77;Reactome: R-HSA-1237112	"Cysteine and methionine metabolism";"Methionine salvage pathway"
XP_053947143.1	5	Reactome: R-HSA-8964539;MetaCyc: PWY-6344;MetaCyc: PWY-4981;MetaCyc: PWY-3341;KEGG: 00330+1.5.1.2	"Glutamate and glutamine metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism"
XP_053967126.1	2	Reactome: R-HSA-174403;Reactome: R-HSA-5578998	"Glutathione synthesis and recycling";"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)"
XP_053945862.1	33	Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-141444;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-159230;Reactome: R-HSA-9648025;Reactome: R-HSA-159236;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-168271;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-191859;Reactome: R-HSA-165054	"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"Transport of the SLBP Dependant Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Separation of Sister Chromatids";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA"
XP_053950185.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053956913.1	3	Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355	"Nitric oxide stimulates guanylate cyclase";"Purine metabolism";"Smooth Muscle Contraction"
XP_053959097.1	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
XP_053957764.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053945869.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-425561	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Sodium/Calcium exchangers"
XP_053953472.1	18	KEGG: 00260+1.8.1.4;KEGG: 00010+1.8.1.4;MetaCyc: PWY-5046;Reactome: R-HSA-389661;Reactome: R-HSA-204174;Reactome: R-HSA-70895;Reactome: R-HSA-71064;KEGG: 00020+1.8.1.4;KEGG: 00640+1.8.1.4;Reactome: R-HSA-5362517;KEGG: 00310+1.8.1.4;KEGG: 00380+1.8.1.4;Reactome: R-HSA-70268;Reactome: R-HSA-6783984;KEGG: 00620+1.8.1.4;Reactome: R-HSA-71403;MetaCyc: PWY-5084;KEGG: 00280+1.8.1.4	"Glycine, serine and threonine metabolism";"Glycolysis / Gluconeogenesis";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Glyoxylate metabolism and glycine degradation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Branched-chain amino acid catabolism";"Lysine catabolism";"Citrate cycle (TCA cycle)";"Propanoate metabolism";"Signaling by Retinoic Acid";"Lysine degradation";"Tryptophan metabolism";"Pyruvate metabolism";"Glycine degradation";"Pyruvate metabolism";"Citric acid cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Valine, leucine and isoleucine degradation"
XP_053966310.1	10	Reactome: R-HSA-9013508;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-210744;Reactome: R-HSA-2197563;Reactome: R-HSA-2894862;Reactome: R-HSA-9013695;Reactome: R-HSA-1912408	"NOTCH3 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH2 intracellular domain regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation"
XP_053954104.1	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
XP_053962836.1	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_053951887.1	8	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Activation of RAC1";"Human cytomegalovirus infection"
XP_053948677.1	3	KEGG: 00480+1.1.1.44;Reactome: R-HSA-71336;KEGG: 00030+1.1.1.44	"Glutathione metabolism";"Pentose phosphate pathway";"Pentose phosphate pathway"
XP_053945644.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053948779.1	3	KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053953016.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-6784531;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"tRNA processing in the nucleus";"mRNA Splicing - Major Pathway"
XP_053957502.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_053958996.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053945227.1	4	Reactome: R-HSA-1650814;Reactome: R-HSA-2243919;Reactome: R-HSA-1474228;Reactome: R-HSA-2214320	"Collagen biosynthesis and modifying enzymes";"Crosslinking of collagen fibrils";"Degradation of the extracellular matrix";"Anchoring fibril formation"
XP_053963739.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Ion channel transport";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
XP_053957847.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053947263.1	2	Reactome: R-HSA-6782315;MetaCyc: PWY-6829	"tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)"
XP_053950330.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_053946170.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053957543.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053948772.1	2	KEGG: 00770+2.7.1.24;MetaCyc: PWY-7851	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis II (eukaryotic)"
XP_053947858.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053956184.1	8	KEGG: 00270+1.1.1.27;MetaCyc: PWY-8086;KEGG: 00620+1.1.1.27;Reactome: R-HSA-70268;MetaCyc: PWY-6901;KEGG: 00010+1.1.1.27;KEGG: 00640+1.1.1.27;MetaCyc: PWY-5481	"Cysteine and methionine metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis";"Propanoate metabolism";"Pyruvate fermentation to (S)-lactate"
XP_053969567.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053960933.1	7	Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-5663220	"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins"
XP_053969582.1	3	Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916	"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium"
XP_053946069.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_053961866.1	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
XP_053952077.1	6	Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604	"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA"
XP_053946707.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053948436.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053963761.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_053952180.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053967699.1	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053966192.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_053960524.1	42	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-427413;Reactome: R-HSA-2299718;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-3214842;Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-110331;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-1912408;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-5693607;Reactome: R-HSA-9018519;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-2559580;Reactome: R-HSA-912446;Reactome: R-HSA-427389;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-3214858;Reactome: R-HSA-3214815;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-977225;Reactome: R-HSA-5693571;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-5334118	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"NoRC negatively regulates rRNA expression";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"HDMs demethylate histones";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"Cleavage of the damaged purine";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Pre-NOTCH Transcription and Translation";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Processing of DNA double-strand break ends";"Estrogen-dependent gene expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"Oxidative Stress Induced Senescence";"Meiotic recombination";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"RMTs methylate histone arginines";"HDACs deacetylate histones";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Amyloid fiber formation";"Nonhomologous End-Joining (NHEJ)";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Meiotic synapsis";"Packaging Of Telomere Ends";"DNA methylation"
XP_053959594.1	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
XP_053948391.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism"
XP_053955183.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway"
XP_053947963.1	3	Reactome: R-HSA-6799198;Reactome: R-HSA-611105;Reactome: R-HSA-1268020	"Complex I biogenesis";"Respiratory electron transport";"Mitochondrial protein import"
XP_053945927.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053958296.1	27	Reactome: R-HSA-3301854;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-168333;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-180910;Reactome: R-HSA-159230;Reactome: R-HSA-159236;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-4615885;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-191859	"Nuclear Pore Complex (NPC) Disassembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Late Events";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP Dependant Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"SUMOylation of DNA replication proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly"
XP_053969573.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053952747.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053959716.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053946714.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053952571.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053962457.1	13	MetaCyc: PWY-7709;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-7182;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-5123;MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-6859;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-7721	"(3R)-linalool biosynthesis";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Linalool biosynthesis I";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"Trans, trans-farnesyl diphosphate biosynthesis";"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis";"All-trans-farnesol biosynthesis";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Methyl phomopsenoate biosynthesis"
XP_053958981.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_053954101.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053963122.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-171319	"rRNA modification in the nucleus and cytosol";"Telomere Extension By Telomerase"
XP_053953699.1	5	Reactome: R-HSA-936964;Reactome: R-HSA-937041;Reactome: R-HSA-937072;Reactome: R-HSA-168164;Reactome: R-HSA-166166	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Toll Like Receptor 3 (TLR3) Cascade";"MyD88-independent TLR4 cascade"
XP_053947277.1	5	Reactome: R-HSA-8875360;Reactome: R-HSA-6807004;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-182971	"InlB-mediated entry of Listeria monocytogenes into host cell";"Negative regulation of MET activity";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"EGFR downregulation"
XP_053957761.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053945620.1	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
XP_053948497.1	5	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport"
XP_053960233.1	3	Reactome: R-HSA-9018519;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053963543.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_053955172.1	11	Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-163359;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555	"PKA activation in glucagon signalling";"Hedgehog 'off' state";"G alpha (i) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon signaling in metabolic regulation";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"G alpha (s) signalling events"
XP_053962311.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463	"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis"
XP_053954540.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053955179.1	7	KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053947678.1	4	Reactome: R-HSA-381771;Reactome: R-HSA-1799339;Reactome: R-HSA-400511;Reactome: R-HSA-422085	"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin"
XP_053957739.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053958937.1	5	Reactome: R-HSA-209543;Reactome: R-HSA-9020702;Reactome: R-HSA-5205685;Reactome: R-HSA-205043;Reactome: R-HSA-209560	"p75NTR recruits signalling complexes";"Interleukin-1 signaling";"Pink/Parkin Mediated Mitophagy";"NRIF signals cell death from the nucleus";"NF-kB is activated and signals survival"
XP_053951834.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053954521.1	12	Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-5620912;Reactome: R-HSA-381038;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-380320;Reactome: R-HSA-3371497	"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Anchoring of the basal body to the plasma membrane";"XBP1(S) activates chaperone genes";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
XP_053955251.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_053969250.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_053951386.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053960131.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053955630.1	14	MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7601;MetaCyc: PWY-6433;MetaCyc: PWY-7602	"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"
XP_053969552.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_053967706.1	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053957208.1	4	Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-674695	"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events"
XP_053964898.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053949165.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053951042.1	8	Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-5689880;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518	"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Ub-specific processing proteases";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2"
XP_053957795.1	5	KEGG: 04150+2.7.11.24;Reactome: R-HSA-4420097;Reactome: R-HSA-168638;Reactome: R-HSA-376172;Reactome: R-HSA-171007	"mTOR signaling pathway";"VEGFA-VEGFR2 Pathway";"NOD1/2 Signaling Pathway";"DSCAM interactions";"p38MAPK events"
XP_053946784.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053956823.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053951049.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_053958251.1	3	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053957607.1	1	KEGG: 00240+3.1.3.89	"Pyrimidine metabolism"
XP_053969980.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053970181.1	2	Reactome: R-HSA-190873;Reactome: R-HSA-399719	"Gap junction degradation";"Trafficking of AMPA receptors"
XP_053967342.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-6807505	"mRNA Splicing - Major Pathway";"RNA polymerase II transcribes snRNA genes"
XP_053955981.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_053969844.1	5	Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-427413	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"NoRC negatively regulates rRNA expression"
XP_053961885.1	30	Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-73772;Reactome: R-HSA-167161;Reactome: R-HSA-5696400;Reactome: R-HSA-112382;Reactome: R-HSA-6781823;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-77075;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-167162;Reactome: R-HSA-73762;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-427413;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-167246;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-5696395;Reactome: R-HSA-75953;Reactome: R-HSA-2564830	"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase I Promoter Escape";"HIV Transcription Initiation";"Dual Incision in GG-NER";"Formation of RNA Pol II elongation complex";"Formation of TC-NER Pre-Incision Complex";"Formation of the Early Elongation Complex";"mRNA Capping";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Tat-mediated elongation of the HIV-1 transcript";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of Incision Complex in GG-NER";"RNA Polymerase II Transcription Initiation";"Cytosolic iron-sulfur cluster assembly"
XP_053967303.1	16	Reactome: R-HSA-1810476;Reactome: R-HSA-1257604;Reactome: R-HSA-5602498;Reactome: R-HSA-209543;Reactome: R-HSA-975110;Reactome: R-HSA-975871;Reactome: R-HSA-5603041;Reactome: R-HSA-975138;Reactome: R-HSA-9020702;Reactome: R-HSA-6811558;Reactome: R-HSA-166058;Reactome: R-HSA-3134963;Reactome: R-HSA-975155;Reactome: R-HSA-5602680;Reactome: R-HSA-5603037;Reactome: R-HSA-1236974	"RIP-mediated NFkB activation via ZBP1";"PIP3 activates AKT signaling";"MyD88 deficiency (TLR2/4)";"p75NTR recruits signalling complexes";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"MyD88 cascade initiated on plasma membrane";"IRAK4 deficiency (TLR2/4)";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"Interleukin-1 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"MyD88 dependent cascade initiated on endosome";"MyD88 deficiency (TLR5)";"IRAK4 deficiency (TLR5)";"ER-Phagosome pathway"
XP_053952774.1	2	Reactome: R-HSA-6804758;Reactome: R-HSA-3214847	"Regulation of TP53 Activity through Acetylation";"HATs acetylate histones"
XP_053951497.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053959006.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053965205.1	5	Reactome: R-HSA-2132295;Reactome: R-HSA-4085001;Reactome: R-HSA-6798695;Reactome: R-HSA-4341670;Reactome: R-HSA-1660662	"MHC class II antigen presentation";"Sialic acid metabolism";"Neutrophil degranulation";"Defective NEU1 causes sialidosis";"Glycosphingolipid metabolism"
XP_053969662.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72165;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_053947722.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053963908.1	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
XP_053952044.1	5	Reactome: R-HSA-186763;Reactome: R-HSA-5218921;Reactome: R-HSA-5658442;Reactome: R-HSA-3928662;Reactome: R-HSA-8849471	"Downstream signal transduction";"VEGFR2 mediated cell proliferation";"Regulation of RAS by GAPs";"EPHB-mediated forward signaling";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"
XP_053957614.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053953349.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053953303.1	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
XP_053969512.1	10	Reactome: R-HSA-9619483;Reactome: R-HSA-6804756;Reactome: R-HSA-200425;Reactome: R-HSA-380972;Reactome: R-HSA-1445148;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-163680;Reactome: R-HSA-9613354;Reactome: R-HSA-2151209	"Activation of AMPK downstream of NMDARs";"Regulation of TP53 Activity through Phosphorylation";"Carnitine metabolism";"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"TP53 Regulates Metabolic Genes";"Macroautophagy";"AMPK inhibits chREBP transcriptional activation activity";"Lipophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation"
XP_053964115.1	3	Reactome: R-HSA-8875656;Reactome: R-HSA-8854214;Reactome: R-HSA-8856828	"MET receptor recycling";"TBC/RABGAPs";"Clathrin-mediated endocytosis"
XP_053969988.1	8	MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7979;Reactome: R-HSA-5083633;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;KEGG: 00514+2.4.1.109	"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Other types of O-glycan biosynthesis"
XP_053954949.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_053958183.1	20	MetaCyc: PWY-7606;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7291;MetaCyc: PWY-6837;MetaCyc: PWY-7007;MetaCyc: PWY-7858;MetaCyc: PWY-7338;KEGG: 00410+1.3.3.6;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7288;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7337;MetaCyc: PWY-7574;MetaCyc: PWY-5136;MetaCyc: PWY-7854;Reactome: R-HSA-9033241;MetaCyc: PWY-7726;MetaCyc: PWY-7340;MetaCyc: PWY-6920	"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Propanoate metabolism";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Methyl ketone biosynthesis (engineered)";"(5Z)-dodecenoate biosynthesis II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"beta-Alanine metabolism";"Fatty acid degradation";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Peroxisomal protein import";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)"
XP_053945391.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_053962469.1	5	MetaCyc: PWY-7560;KEGG: 00900+2.2.1.7;KEGG: 00730+2.2.1.7;MetaCyc: PWY-6891;MetaCyc: PWY-6892	"Methylerythritol phosphate pathway II";"Terpenoid backbone biosynthesis";"Thiamine metabolism";"Thiazole biosynthesis II (aerobic bacteria)";"Thiazole biosynthesis I (facultative anaerobic bacteria)"
XP_053958211.1	2	Reactome: R-HSA-5663220;Reactome: R-HSA-376176	"RHO GTPases Activate Formins";"Signaling by ROBO receptors"
XP_053952895.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_053963564.1	7	Reactome: R-HSA-5696394;Reactome: R-HSA-5696400;Reactome: R-HSA-2173795;Reactome: R-HSA-5696395;Reactome: R-HSA-3108214;Reactome: R-HSA-5685939;Reactome: R-HSA-110362	"DNA Damage Recognition in GG-NER";"Dual Incision in GG-NER";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Formation of Incision Complex in GG-NER";"SUMOylation of DNA damage response and repair proteins";"HDR through MMEJ (alt-NHEJ)";"POLB-Dependent Long Patch Base Excision Repair"
XP_053962462.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053951436.1	7	Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053956778.1	5	Reactome: R-HSA-380994;Reactome: R-HSA-9648895;KEGG: 00250+6.3.5.4;Reactome: R-HSA-9633012;Reactome: R-HSA-8963693	"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK1 (HRI) to heme deficiency";"Alanine, aspartate and glutamate metabolism";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism"
XP_053956040.1	16	Reactome: R-HSA-2219530;Reactome: R-HSA-5673001;Reactome: R-HSA-8863795;Reactome: R-HSA-6811558;Reactome: R-HSA-1251985;Reactome: R-HSA-1236394;Reactome: R-HSA-6785631;Reactome: R-HSA-9664565;Reactome: R-HSA-1250347;Reactome: R-HSA-1963642;Reactome: R-HSA-1250196;Reactome: R-HSA-1257604;Reactome: R-HSA-1227986;Reactome: R-HSA-8847993;Reactome: R-HSA-1250342;Reactome: R-HSA-1963640	"Constitutive Signaling by Aberrant PI3K in Cancer";"RAF/MAP kinase cascade";"Downregulation of ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Nuclear signaling by ERBB4";"Signaling by ERBB4";"ERBB2 Regulates Cell Motility";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB4 signaling";"PI3K events in ERBB2 signaling";"SHC1 events in ERBB2 signaling";"PIP3 activates AKT signaling";"Signaling by ERBB2";"ERBB2 Activates PTK6 Signaling";"PI3K events in ERBB4 signaling";"GRB2 events in ERBB2 signaling"
XP_053955281.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053945772.1	2	Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_053950418.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_053953706.1	5	Reactome: R-HSA-936964;Reactome: R-HSA-937041;Reactome: R-HSA-937072;Reactome: R-HSA-168164;Reactome: R-HSA-166166	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Toll Like Receptor 3 (TLR3) Cascade";"MyD88-independent TLR4 cascade"
XP_053955996.1	7	Reactome: R-HSA-1660516;MetaCyc: PWY-6351;MetaCyc: PWY-6352;KEGG: 04070+2.7.1.67;KEGG: 00562+2.7.1.67;Reactome: R-HSA-1660499;Reactome: R-HSA-1660514	"Synthesis of PIPs at the early endosome membrane";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"3-phosphoinositide biosynthesis";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the Golgi membrane"
XP_053957874.1	6	Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220	"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins"
XP_053970196.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053962396.1	6	KEGG: 04070+2.7.11.13;Reactome: R-HSA-114516;Reactome: R-HSA-418597;Reactome: R-HSA-76005;Reactome: R-HSA-5099900;Reactome: R-HSA-416993	"Phosphatidylinositol signaling system";"Disinhibition of SNARE formation";"G alpha (z) signalling events";"Response to elevated platelet cytosolic Ca2+";"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors"
XP_053948365.1	13	Reactome: R-HSA-5218920;Reactome: R-HSA-9639288;Reactome: R-HSA-389357;Reactome: R-HSA-380972;Reactome: R-HSA-6804757;Reactome: R-HSA-8943724;Reactome: R-HSA-166208;Reactome: R-HSA-3371571;Reactome: R-HSA-1257604;Reactome: R-HSA-5674400;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-165159	"VEGFR2 mediated vascular permeability";"Amino acids regulate mTORC1";"CD28 dependent PI3K/Akt signaling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of TP53 Degradation";"Regulation of PTEN gene transcription";"mTORC1-mediated signalling";"HSF1-dependent transactivation";"PIP3 activates AKT signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTOR signalling"
XP_053958426.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_053964890.1	4	Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation"
XP_053969665.1	13	KEGG: 00600+3.2.1.23;Reactome: R-HSA-4341670;MetaCyc: PWY-6807;Reactome: R-HSA-2022857;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2206308;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-2024096;Reactome: R-HSA-6798695	"Sphingolipid metabolism";"Defective NEU1 causes sialidosis";"Xyloglucan degradation II (exoglucanase)";"Keratan sulfate degradation";"Galactose metabolism";"Other glycan degradation";"MPS IV - Morquio syndrome B";"Sialic acid metabolism";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"HS-GAG degradation";"Neutrophil degranulation"
XP_053950029.1	12	Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220	"Aggrephagy";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins"
XP_053947725.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053969099.1	7	KEGG: 00600+2.4.1.80;MetaCyc: PWY-7838;Reactome: R-HSA-1660662;MetaCyc: PWY-7839;MetaCyc: PWY-7836;MetaCyc: PWY-5129;MetaCyc: PWY-7841	"Sphingolipid metabolism";"Globo-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism";"Lacto-series glycosphingolipids biosynthesis";"Ganglio-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)";"Neolacto-series glycosphingolipids biosynthesis"
XP_053967345.1	2	Reactome: R-HSA-6807505;Reactome: R-HSA-72163	"RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway"
XP_053962221.1	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
XP_053952076.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053950808.1	2	Reactome: R-HSA-1299308;Reactome: R-HSA-5576886	"Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)";"Phase 4 - resting membrane potential"
XP_053959704.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053963477.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_053948437.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_053969656.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902	"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation"
XP_053959084.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053951045.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_053969566.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053954468.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053962948.1	3	MetaCyc: PWY-7420;Reactome: R-HSA-426048;KEGG: 00561+3.1.1.23	"Monoacylglycerol metabolism (yeast)";"Arachidonate production from DAG";"Glycerolipid metabolism"
XP_053951894.1	4	KEGG: 00030+1.1.1.49;KEGG: 00480+1.1.1.49;MetaCyc: PWY-8004;MetaCyc: PWY-7268	"Pentose phosphate pathway";"Glutathione metabolism";"Entner-Doudoroff pathway I";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
XP_053958997.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053955348.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053964159.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053957846.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_053945226.1	52	Reactome: R-HSA-75953;Reactome: R-HSA-167200;Reactome: R-HSA-9018519;Reactome: R-HSA-1834949;Reactome: R-HSA-73780;Reactome: R-HSA-167242;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-6781827;Reactome: R-HSA-167162;Reactome: R-HSA-6782135;Reactome: R-HSA-203927;Reactome: R-HSA-6781823;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-73776;Reactome: R-HSA-76061;Reactome: R-HSA-5601884;Reactome: R-HSA-167238;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-5578749;Reactome: R-HSA-76071;Reactome: R-HSA-5617472;Reactome: R-HSA-76066;Reactome: R-HSA-167158;Reactome: R-HSA-6782210;Reactome: R-HSA-72165;Reactome: R-HSA-8851708;Reactome: R-HSA-6807505;Reactome: R-HSA-167246;Reactome: R-HSA-168325;Reactome: R-HSA-6803529;Reactome: R-HSA-5250924;Reactome: R-HSA-167243;Reactome: R-HSA-77075;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-167287;Reactome: R-HSA-72163;Reactome: R-HSA-73863;Reactome: R-HSA-72086;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-73772;Reactome: R-HSA-72203;Reactome: R-HSA-6796648;Reactome: R-HSA-674695	"RNA Polymerase II Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Estrogen-dependent gene expression";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Chain Elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II HIV Promoter Escape";"Dual incision in TC-NER";"MicroRNA (miRNA) biogenesis";"Formation of TC-NER Pre-Incision Complex";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"RNA Polymerase II Promoter Escape";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"PIWI-interacting RNA (piRNA) biogenesis";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"Transcriptional regulation by small RNAs";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Formation of the HIV-1 Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Minor Pathway";"Signaling by FGFR2 IIIa TM";"RNA polymerase II transcribes snRNA genes";"Tat-mediated elongation of the HIV-1 transcript";"Viral Messenger RNA Synthesis";"FGFR2 alternative splicing";"B-WICH complex positively regulates rRNA expression";"Tat-mediated HIV elongation arrest and recovery";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"RNA Polymerase I Transcription Termination";"mRNA Capping";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Promoter Escape";"Processing of Capped Intron-Containing Pre-mRNA";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events"
XP_053967004.1	1	Reactome: R-HSA-8953750	"Transcriptional Regulation by E2F6"
XP_053969555.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_053962940.1	12	MetaCyc: PWY-5484;MetaCyc: PWY-1861;KEGG: 00710+4.1.2.13;Reactome: R-HSA-70263;MetaCyc: PWY-7385;MetaCyc: PWY-1042;KEGG: 00051+4.1.2.13;MetaCyc: PWY-6142;KEGG: 00030+4.1.2.13;Reactome: R-HSA-70171;KEGG: 00680+4.1.2.13;KEGG: 00010+4.1.2.13	"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Fructose and mannose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pentose phosphate pathway";"Glycolysis";"Methane metabolism";"Glycolysis / Gluconeogenesis"
XP_053962884.1	4	Reactome: R-HSA-1268020;Reactome: R-HSA-8950505;Reactome: R-HSA-8949613;Reactome: R-HSA-3371453	"Mitochondrial protein import";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Cristae formation";"Regulation of HSF1-mediated heat shock response"
XP_053958936.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053961577.1	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
XP_053954460.1	7	Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-198323;Reactome: R-HSA-8854214;Reactome: R-HSA-165181;Reactome: R-HSA-5674400;Reactome: R-HSA-380972	"Macroautophagy";"TP53 Regulates Metabolic Genes";"AKT phosphorylates targets in the cytosol";"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB";"Constitutive Signaling by AKT1 E17K in Cancer";"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_053967661.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837	"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases"
XP_053958698.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053961873.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053952343.1	3	Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis"
XP_053947135.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053949740.1	3	KEGG: 00790+2.8.1.9;Reactome: R-HSA-947581;MetaCyc: PWY-5963	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Thio-molybdenum cofactor biosynthesis"
XP_053945775.1	2	KEGG: 00770+6.3.2.5;Reactome: R-HSA-196783	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
XP_053960116.1	42	Reactome: R-HSA-9018519;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-2559580;Reactome: R-HSA-912446;Reactome: R-HSA-3214815;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-5334118;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-427413;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-2299718;Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-110331;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-5693607	"Estrogen-dependent gene expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"Oxidative Stress Induced Senescence";"Meiotic recombination";"HDACs deacetylate histones";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"DNA methylation";"Packaging Of Telomere Ends";"Meiotic synapsis";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"NoRC negatively regulates rRNA expression";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"Condensation of Prophase Chromosomes";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"Cleavage of the damaged purine";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Processing of DNA double-strand break ends"
XP_053962647.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes"
XP_053960993.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-197264;MetaCyc: PWY-5381;Reactome: R-HSA-1368108;KEGG: 00760+6.3.4.21	"Neutrophil degranulation";"Nicotinamide salvaging";"Pyridine nucleotide cycling (plants)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinate and nicotinamide metabolism"
XP_053959375.1	4	MetaCyc: PWY-6281;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.11;Reactome: R-HSA-2408557	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenocysteine synthesis"
XP_053955340.1	3	KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067;Reactome: R-HSA-3322077	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen synthesis"
XP_053966880.1	1	Reactome: R-HSA-200425	"Carnitine metabolism"
XP_053952892.1	1	Reactome: R-HSA-1855231	"Synthesis of IPs in the ER lumen"
XP_053950274.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053961138.1	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
XP_053962465.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule"
XP_053948496.1	12	Reactome: R-HSA-3371497;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-141444;Reactome: R-HSA-5663220	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Mitotic Prometaphase";"Aggrephagy";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins"
XP_053945926.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053967551.1	15	Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167242;Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-167290;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-167243;Reactome: R-HSA-167152	"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat"
XP_053969515.1	10	Reactome: R-HSA-200425;Reactome: R-HSA-6804756;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-380972;Reactome: R-HSA-9613354;Reactome: R-HSA-163680;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-2151209	"Carnitine metabolism";"Regulation of TP53 Activity through Phosphorylation";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Energy dependent regulation of mTOR by LKB1-AMPK";"Lipophagy";"AMPK inhibits chREBP transcriptional activation activity";"Macroautophagy";"TP53 Regulates Metabolic Genes";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation"
XP_053952746.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053964112.1	3	Reactome: R-HSA-8875656;Reactome: R-HSA-8854214;Reactome: R-HSA-8856828	"MET receptor recycling";"TBC/RABGAPs";"Clathrin-mediated endocytosis"
XP_053958297.1	27	Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-159230;Reactome: R-HSA-159236;Reactome: R-HSA-180910;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-168333;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-168271	"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Transport of the SLBP Dependant Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Vpr-mediated nuclear import of PICs";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus"
XP_053962456.1	13	MetaCyc: PWY-5123;MetaCyc: PWY-7709;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7182;MetaCyc: PWY-6383;MetaCyc: PWY-5122;MetaCyc: PWY-6859;MetaCyc: PWY-7721;MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1	"Trans, trans-farnesyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Linalool biosynthesis I";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"All-trans-farnesol biosynthesis";"Methyl phomopsenoate biosynthesis";"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis"
XP_053953345.1	7	Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_053959717.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053949933.1	4	Reactome: R-HSA-5358493;MetaCyc: PWY-6482;Reactome: R-HSA-8849175;MetaCyc: PWY-7546	"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)";"Threonine catabolism";"Diphthamide biosynthesis II (eukaryotes)"
XP_053964624.1	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
XP_053967695.1	30	Reactome: R-HSA-199418;Reactome: R-HSA-111447;Reactome: R-HSA-69202;Reactome: R-HSA-8876198;KEGG: 04151+2.7.11.1;Reactome: R-HSA-389513;Reactome: R-HSA-8948751;Reactome: R-HSA-6804757;Reactome: R-HSA-6804758;Reactome: R-HSA-5218920;Reactome: R-HSA-392451;Reactome: R-HSA-6804759;Reactome: R-HSA-198323;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-8941332;Reactome: R-HSA-198693;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69656;Reactome: R-HSA-5674400;Reactome: R-HSA-211163;Reactome: R-HSA-1257604;Reactome: R-HSA-1358803;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-9634638;Reactome: R-HSA-9614399	"Negative regulation of the PI3K/AKT network";"Activation of BAD and translocation to mitochondria";"Cyclin E associated events during G1/S transition";"RAB GEFs exchange GTP for GDP on RABs";"PI3K-Akt signaling pathway";"CTLA4 inhibitory signaling";"Regulation of PTEN stability and activity";"Regulation of TP53 Degradation";"Regulation of TP53 Activity through Acetylation";"VEGFR2 mediated vascular permeability";"G beta:gamma signalling through PI3Kgamma";"Regulation of TP53 Activity through Association with Co-factors";"AKT phosphorylates targets in the cytosol";"Thermogenesis";"Human immunodeficiency virus 1 infection";"RUNX2 regulates genes involved in cell migration";"AKT phosphorylates targets in the nucleus";"Relaxin signaling pathway";"Cyclin A:Cdk2-associated events at S phase entry";"Constitutive Signaling by AKT1 E17K in Cancer";"AKT-mediated inactivation of FOXO1A";"PIP3 activates AKT signaling";"Downregulation of ERBB2:ERBB3 signaling";"Human papillomavirus infection";"TP53 Regulates Metabolic Genes";"mTOR signaling pathway";"Human cytomegalovirus infection";"CD28 dependent PI3K/Akt signaling";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Regulation of localization of FOXO transcription factors"
XP_053945331.1	6	Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-450513	"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_053957606.1	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
XP_053962733.1	2	Reactome: R-HSA-1482798;Reactome: R-HSA-1268020	"Acyl chain remodeling of CL";"Mitochondrial protein import"
XP_053965730.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053946065.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_053968943.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053945369.1	7	Reactome: R-HSA-2660826;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-1442490;Reactome: R-HSA-2691232;Reactome: R-HSA-177929	"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Collagen degradation";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Signaling by EGFR"
XP_053959769.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053961544.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053962336.1	8	Reactome: R-HSA-432040;Reactome: R-HSA-442720;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-180024;Reactome: R-HSA-381676;Reactome: R-HSA-983231;Reactome: R-HSA-163615	"Vasopressin regulates renal water homeostasis via Aquaporins";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"DARPP-32 events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Factors involved in megakaryocyte development and platelet production";"PKA activation"
XP_053957505.1	3	Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.4	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053951387.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053958340.1	7	Reactome: R-HSA-70263;MetaCyc: PWY-5484;KEGG: 00010+3.1.3.11;KEGG: 00051+3.1.3.11;KEGG: 00030+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11	"Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"Methane metabolism"
XP_053953537.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053951369.1	4	KEGG: 00230+2.7.4.3;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219	"Purine metabolism";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis"
XP_053963735.1	3	Reactome: R-HSA-6804760;Reactome: R-HSA-191859;Reactome: R-HSA-3214858	"Regulation of TP53 Activity through Methylation";"snRNP Assembly";"RMTs methylate histone arginines"
XP_053966810.1	7	MetaCyc: PWY-3561;Reactome: R-HSA-1483166;MetaCyc: PWY-7039;Reactome: R-HSA-1483148;KEGG: 00565+3.1.4.4;Reactome: R-HSA-2029485;KEGG: 00564+3.1.4.4	"Choline biosynthesis III";"Synthesis of PA";"Phosphatidate metabolism, as a signaling molecule";"Synthesis of PG";"Ether lipid metabolism";"Role of phospholipids in phagocytosis";"Glycerophospholipid metabolism"
XP_053965264.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_053950648.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_053964830.1	7	Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-4615885;Reactome: R-HSA-68877	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase"
XP_053967707.1	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053959121.1	5	Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-983231	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Factors involved in megakaryocyte development and platelet production"
XP_053962397.1	6	Reactome: R-HSA-5099900;Reactome: R-HSA-416993;Reactome: R-HSA-418597;Reactome: R-HSA-76005;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114516	"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors";"G alpha (z) signalling events";"Response to elevated platelet cytosolic Ca2+";"Phosphatidylinositol signaling system";"Disinhibition of SNARE formation"
XP_053969691.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-6798695	"Protein ubiquitination";"Neutrophil degranulation"
XP_053955690.1	3	Reactome: R-HSA-9029569;Reactome: R-HSA-8964058;Reactome: R-HSA-1369062	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"HDL remodeling";"ABC transporters in lipid homeostasis"
XP_053950947.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053962123.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053959140.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053964838.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053950640.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053953031.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053947400.1	4	KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-7119;MetaCyc: PWY-6483	"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)";"Ceramide degradation (generic)"
XP_053953707.1	5	Reactome: R-HSA-166166;Reactome: R-HSA-168164;Reactome: R-HSA-937072;Reactome: R-HSA-937041;Reactome: R-HSA-936964	"MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IKK complex recruitment mediated by RIP1";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"
XP_053948045.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053958348.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053955997.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053967714.1	30	KEGG: 05163+2.7.11.1;Reactome: R-HSA-9634638;Reactome: R-HSA-389357;Reactome: R-HSA-9614399;Reactome: R-HSA-8941332;Reactome: R-HSA-198693;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5674400;Reactome: R-HSA-69656;Reactome: R-HSA-211163;Reactome: R-HSA-1257604;Reactome: R-HSA-1358803;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 04150+2.7.11.1;Reactome: R-HSA-8948751;Reactome: R-HSA-6804757;Reactome: R-HSA-6804758;Reactome: R-HSA-5218920;Reactome: R-HSA-392451;Reactome: R-HSA-6804759;Reactome: R-HSA-198323;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-199418;Reactome: R-HSA-69202;Reactome: R-HSA-111447;Reactome: R-HSA-8876198;KEGG: 04151+2.7.11.1;Reactome: R-HSA-389513	"Human cytomegalovirus infection";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"CD28 dependent PI3K/Akt signaling";"Regulation of localization of FOXO transcription factors";"RUNX2 regulates genes involved in cell migration";"AKT phosphorylates targets in the nucleus";"Relaxin signaling pathway";"Constitutive Signaling by AKT1 E17K in Cancer";"Cyclin A:Cdk2-associated events at S phase entry";"AKT-mediated inactivation of FOXO1A";"PIP3 activates AKT signaling";"Downregulation of ERBB2:ERBB3 signaling";"Human papillomavirus infection";"TP53 Regulates Metabolic Genes";"mTOR signaling pathway";"Regulation of PTEN stability and activity";"Regulation of TP53 Degradation";"Regulation of TP53 Activity through Acetylation";"VEGFR2 mediated vascular permeability";"G beta:gamma signalling through PI3Kgamma";"Regulation of TP53 Activity through Association with Co-factors";"AKT phosphorylates targets in the cytosol";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Negative regulation of the PI3K/AKT network";"Cyclin E associated events during G1/S transition";"Activation of BAD and translocation to mitochondria";"RAB GEFs exchange GTP for GDP on RABs";"PI3K-Akt signaling pathway";"CTLA4 inhibitory signaling"
XP_053952364.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053967178.1	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
XP_053962503.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053965964.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_053953754.1	3	KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783;MetaCyc: PWY-3961	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II"
XP_053959014.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053946016.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053946479.1	6	KEGG: 00260+2.6.1.52;MetaCyc: PWY-8010;KEGG: 00680+2.6.1.52;KEGG: 00270+2.6.1.52;Reactome: R-HSA-977347;KEGG: 00750+2.6.1.52	"Glycine, serine and threonine metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Methane metabolism";"Cysteine and methionine metabolism";"Serine biosynthesis";"Vitamin B6 metabolism"
XP_053949521.1	11	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-450302;Reactome: R-HSA-4420097;Reactome: R-HSA-2559580;Reactome: R-HSA-171007;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"activated TAK1 mediates p38 MAPK activation";"VEGFA-VEGFR2 Pathway";"Oxidative Stress Induced Senescence";"p38MAPK events";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053961541.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053969715.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053964640.1	14	Reactome: R-HSA-426486;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-8986944;Reactome: R-HSA-203927;Reactome: R-HSA-5628897;Reactome: R-HSA-4086398;Reactome: R-HSA-1912408;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723	"Small interfering RNA (siRNA) biogenesis";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Transcriptional Regulation by MECP2";"MicroRNA (miRNA) biogenesis";"TP53 Regulates Metabolic Genes";"Ca2+ pathway";"Pre-NOTCH Transcription and Translation";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation"
XP_053946736.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_053963066.1	12	Reactome: R-HSA-193692;Reactome: R-HSA-2979096;Reactome: R-HSA-9017802;Reactome: R-HSA-205043;Reactome: R-HSA-2644606;Reactome: R-HSA-977225;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-9013700;Reactome: R-HSA-1251985;Reactome: R-HSA-3928665	"Regulated proteolysis of p75NTR";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"NRIF signals cell death from the nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Amyloid fiber formation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"EPH-ephrin mediated repulsion of cells"
XP_053961100.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053951334.1	7	KEGG: 00230+1.1.1.205;MetaCyc: PWY-7221;Reactome: R-HSA-6798695;Reactome: R-HSA-73817;MetaCyc: PWY-6596;MetaCyc: PWY-5695;KEGG: 00983+1.1.1.205	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Neutrophil degranulation";"Purine ribonucleoside monophosphate biosynthesis";"Adenosine nucleotides degradation I";"Inosine 5'-phosphate degradation";"Drug metabolism - other enzymes"
XP_053945856.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-425561	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Sodium/Calcium exchangers"
XP_053950830.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_053961763.1	13	Reactome: R-HSA-2022857;Reactome: R-HSA-4341670;MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;KEGG: 00052+3.2.1.23;Reactome: R-HSA-2206308;KEGG: 00511+3.2.1.23;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662	"Keratan sulfate degradation";"Defective NEU1 causes sialidosis";"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Neutrophil degranulation";"HS-GAG degradation";"Galactose metabolism";"MPS IV - Morquio syndrome B";"Other glycan degradation";"Sialic acid metabolism";"Glycosphingolipid metabolism"
XP_053961499.1	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
XP_053957347.1	8	MetaCyc: PWY-7573;MetaCyc: PWY-66;MetaCyc: PWY-5738;KEGG: 00520+4.2.1.47;Reactome: R-HSA-6787639;KEGG: 00051+4.2.1.47;MetaCyc: PWY-5740;MetaCyc: PWY-5739	"GDP-mycosamine biosynthesis";"GDP-L-fucose biosynthesis I (from GDP-D-mannose)";"GDP-6-deoxy-D-talose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"GDP-fucose biosynthesis";"Fructose and mannose metabolism";"GDP-L-colitose biosynthesis";"GDP-D-perosamine biosynthesis"
XP_053952361.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053945865.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Sodium/Calcium exchangers";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
XP_053959667.1	20	MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7337;MetaCyc: PWY-7574;MetaCyc: PWY-7854;MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7288;MetaCyc: PWY-7726;MetaCyc: PWY-7340;MetaCyc: PWY-6920;Reactome: R-HSA-9033241;MetaCyc: PWY-7007;MetaCyc: PWY-7858;MetaCyc: PWY-7338;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-7291;MetaCyc: PWY-6837;KEGG: 00410+1.3.3.6	"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"Fatty acid beta-oxidation VII (yeast peroxisome)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Peroxisomal protein import";"Methyl ketone biosynthesis (engineered)";"(5Z)-dodecenoate biosynthesis II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"beta-Alanine metabolism"
XP_053946797.1	5	Reactome: R-HSA-6782210;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827	"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
XP_053959445.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053947310.1	4	Reactome: R-HSA-166058;Reactome: R-HSA-975138;Reactome: R-HSA-6799198;Reactome: R-HSA-975871	"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"Complex I biogenesis";"MyD88 cascade initiated on plasma membrane"
XP_053952339.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053951484.1	5	Reactome: R-HSA-190873;Reactome: R-HSA-3928665;Reactome: R-HSA-196025;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Gap junction degradation";"EPH-ephrin mediated repulsion of cells";"Formation of annular gap junctions";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053959853.1	8	KEGG: 00195+7.1.2.2;MetaCyc: PWY-7980;Reactome: R-HSA-983712;KEGG: 00190+7.1.2.2;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Photosynthesis";"ATP biosynthesis";"Ion channel transport";"Oxidative phosphorylation";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
XP_053969694.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053959124.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053954186.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_053946126.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053961355.1	24	Reactome: R-HSA-983231;Reactome: R-HSA-111931;Reactome: R-HSA-163615;Reactome: R-HSA-163358;Reactome: R-HSA-392517;KEGG: 04150+2.7.11.11;Reactome: R-HSA-5621575;Reactome: R-HSA-9010642;Reactome: R-HSA-180024;Reactome: R-HSA-9634600;Reactome: R-HSA-5610785;Reactome: R-HSA-8963896;Reactome: R-HSA-8853659;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-422356;Reactome: R-HSA-432040;Reactome: R-HSA-442720;Reactome: R-HSA-4420097;Reactome: R-HSA-163560;Reactome: R-HSA-5610783;Reactome: R-HSA-381676;Reactome: R-HSA-5610787;Reactome: R-HSA-164378	"Factors involved in megakaryocyte development and platelet production";"PKA-mediated phosphorylation of CREB";"PKA activation";"PKA-mediated phosphorylation of key metabolic factors";"Rap1 signalling";"mTOR signaling pathway";"CD209 (DC-SIGN) signaling";"ROBO receptors bind AKAP5";"DARPP-32 events";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"GLI3 is processed to GLI3R by the proteasome";"HDL assembly";"RET signaling";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"Regulation of insulin secretion";"Vasopressin regulates renal water homeostasis via Aquaporins";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"VEGFA-VEGFR2 Pathway";"Triglyceride catabolism";"Degradation of GLI2 by the proteasome";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Hedgehog 'off' state";"PKA activation in glucagon signalling"
XP_053965995.1	8	Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68689;Reactome: R-HSA-68962;Reactome: R-HSA-68616;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68867	"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"CDC6 association with the ORC:origin complex";"Activation of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the pre-replicative complex"
XP_053966220.1	10	Reactome: R-HSA-2206292;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.23;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23	"MPS VII - Sly syndrome";"Other glycan degradation";"Galactose metabolism";"Sphingolipid metabolism";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Neutrophil degranulation";"HS-GAG degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series"
XP_053950112.1	56	Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-180534;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-4608870;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-202424	"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Vpu mediated degradation of CD4";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Asymmetric localization of PCP proteins";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"Neddylation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Degradation of AXIN";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"Downstream TCR signaling"
XP_053953803.1	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_053964800.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053947438.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053953796.1	14	Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.51;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-7587	"Synthesis of PA";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)"
XP_053965080.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053962224.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053963990.1	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053968010.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport"
XP_053965538.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053962742.1	10	Reactome: R-HSA-3214847;Reactome: R-HSA-201722;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5689880;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Ub-specific processing proteases";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053949134.1	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
XP_053948856.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_053959701.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053963085.1	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
XP_053953393.1	7	MetaCyc: PWY-7805;Reactome: R-HSA-74217;MetaCyc: PWY-6605;MetaCyc: PWY-7807;Reactome: R-HSA-6798695;MetaCyc: PWY-6610;KEGG: 00230+2.4.2.7	"(aminomethyl)phosphonate degradation";"Purine salvage";"Adenine and adenosine salvage II";"Glyphosate degradation III";"Neutrophil degranulation";"Adenine salvage";"Purine metabolism"
XP_053949949.1	2	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_053960460.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_053948865.1	5	MetaCyc: PWY-7919;MetaCyc: PWY-7918;KEGG: 00510+3.2.1.106;Reactome: R-HSA-532668;Reactome: R-HSA-4793954	"Protein N-glycosylation processing phase (plants and animals)";"Protein N-glycosylation processing phase (yeast)";"N-Glycan biosynthesis";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Defective MOGS causes MOGS-CDG (CDG-2b)"
XP_053953127.1	1	Reactome: R-HSA-2467813	"Separation of Sister Chromatids"
XP_053962896.1	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
XP_053949942.1	2	Reactome: R-HSA-164843;Reactome: R-HSA-5693571	"2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)"
XP_053963697.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053947380.1	4	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Ion channel transport"
XP_053946453.1	6	Reactome: R-HSA-9010553;Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-975957	"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053962072.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_053965295.1	9	MetaCyc: PWY-7003;MetaCyc: PWY-5484;Reactome: R-HSA-70171;KEGG: 00710+1.2.1.12;Reactome: R-HSA-70263;MetaCyc: PWY-1042;KEGG: 00010+1.2.1.12;MetaCyc: PWY-8004;MetaCyc: PWY-6901	"Glycerol degradation to butanol";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway I";"Superpathway of glucose and xylose degradation"
XP_053968018.1	2	Reactome: R-HSA-201722;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex"
XP_053950159.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_053948334.1	2	Reactome: R-HSA-8873719;Reactome: R-HSA-8876198	"RAB geranylgeranylation";"RAB GEFs exchange GTP for GDP on RABs"
XP_053946845.1	14	MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7619;MetaCyc: PWY-7724;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601	"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Sciadonate biosynthesis";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"
XP_053960245.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_053965163.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053956975.1	15	Reactome: R-HSA-8934593;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-2559580;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459;Reactome: R-HSA-9029569;Reactome: R-HSA-4086398;Reactome: R-HSA-1912408;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-2559585	"Regulation of RUNX1 Expression and Activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Oxidative Stress Induced Senescence";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Ca2+ pathway";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Oncogene Induced Senescence"
XP_053964398.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053959096.1	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
XP_053955206.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053960026.1	7	Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-380972;Reactome: R-HSA-166208	"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTOR signalling";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling"
XP_053964974.1	10	Reactome: R-HSA-9022692;Reactome: R-HSA-3899300;Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-9022699;Reactome: R-HSA-9022538;Reactome: R-HSA-983231;Reactome: R-HSA-427413	"Regulation of MECP2 expression and activity";"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression"
XP_053947430.1	17	Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-6790901;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553	"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"rRNA modification in the nucleus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs"
XP_053963290.1	11	Reactome: R-HSA-1660517;Reactome: R-HSA-168138;Reactome: R-HSA-1660516;Reactome: R-HSA-1660514;KEGG: 04070+2.7.1.137;Reactome: R-HSA-1632852;MetaCyc: PWY-6352;Reactome: R-HSA-5668599;Reactome: R-HSA-109704;Reactome: R-HSA-1660499;KEGG: 00562+2.7.1.137	"Synthesis of PIPs at the late endosome membrane";"Toll Like Receptor 9 (TLR9) Cascade";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the Golgi membrane";"Phosphatidylinositol signaling system";"Macroautophagy";"3-phosphoinositide biosynthesis";"RHO GTPases Activate NADPH Oxidases";"PI3K Cascade";"Synthesis of PIPs at the plasma membrane";"Inositol phosphate metabolism"
XP_053962924.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053967842.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053952412.1	2	MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis"
XP_053963535.1	6	Reactome: R-HSA-5632987;Reactome: R-HSA-912446;Reactome: R-HSA-5358606;Reactome: R-HSA-5358565;Reactome: R-HSA-5545483;Reactome: R-HSA-6796648	"Defective Mismatch Repair Associated With PMS2";"Meiotic recombination";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MLH1";"TP53 Regulates Transcription of DNA Repair Genes"
XP_053966228.1	10	KEGG: 00531+3.2.1.23;Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2160916;Reactome: R-HSA-2206292;KEGG: 00600+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23	"Glycosaminoglycan degradation";"HS-GAG degradation";"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Hyaluronan uptake and degradation";"MPS VII - Sly syndrome";"Sphingolipid metabolism";"Galactose metabolism";"Other glycan degradation"
XP_053951454.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053945093.1	2	Reactome: R-HSA-8853659;Reactome: R-HSA-5673001	"RET signaling";"RAF/MAP kinase cascade"
XP_053959587.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053969785.1	2	MetaCyc: PWY-6981;KEGG: 00520+2.4.1.16	"Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism"
XP_053949242.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6807004;Reactome: R-HSA-202427	"Neutrophil degranulation";"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains"
XP_053959883.1	13	KEGG: 00511+3.2.1.52;MetaCyc: PWY-7883;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101;KEGG: 00603+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;KEGG: 00520+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916	"Other glycan degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid metabolism";"CS/DS degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Hyaluronan uptake and degradation"
XP_053966164.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_053961229.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-6794361;Reactome: R-HSA-8856828;Reactome: R-HSA-5250958	"Cargo recognition for clathrin-mediated endocytosis";"Neurexins and neuroligins";"Clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)"
XP_053961413.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_053965275.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (q) signalling events";"Peptide ligand-binding receptors"
XP_053957970.1	3	KEGG: 00860+2.5.1.141;MetaCyc: PWY-7856;Reactome: R-HSA-189451	"Porphyrin and chlorophyll metabolism";"Heme a biosynthesis";"Heme biosynthesis"
XP_053950291.1	10	MetaCyc: PWY-5826;MetaCyc: PWY-7559;MetaCyc: PWY-7112;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;MetaCyc: PWY-6842;MetaCyc: PWY-4041;KEGG: 00460+2.3.2.2	"Hypoglycin biosynthesis";"Glutathione degradation (DUG pathway";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I";"Glutathione metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Glutathione-mediated detoxification II";"Gamma-glutamyl cycle";"Cyanoamino acid metabolism"
XP_053956995.1	3	Reactome: R-HSA-2024101;Reactome: R-HSA-2206296;Reactome: R-HSA-2024096	"CS/DS degradation";"MPS II - Hunter syndrome";"HS-GAG degradation"
XP_053957677.1	4	Reactome: R-HSA-5678895;Reactome: R-HSA-5358346;Reactome: R-HSA-382556;Reactome: R-HSA-5362768	"Defective CFTR causes cystic fibrosis";"Hedgehog ligand biogenesis";"ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD"
XP_053951561.1	14	MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.51;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-5981;MetaCyc: PWY-6453;MetaCyc: PWY-7589;MetaCyc: PWY-7411	"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PA";"Plasmalogen biosynthesis";"CDP-diacylglycerol biosynthesis III";"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)"
XP_053955220.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053963857.1	14	MetaCyc: PWY-8053;Reactome: R-HSA-1483213;KEGG: 00561+3.1.3.4;KEGG: 00600+3.1.3.4;MetaCyc: PWY-7782;MetaCyc: PWY-6453;KEGG: 00565+3.1.3.4;MetaCyc: PWY-8051;MetaCyc: PWY-8052;Reactome: R-HSA-4419969;MetaCyc: PWY-8055;KEGG: 00564+3.1.3.4;Reactome: R-HSA-75109;Reactome: R-HSA-1483191	"Anandamide biosynthesis II";"Synthesis of PE";"Glycerolipid metabolism";"Sphingolipid metabolism";"Plasmalogen biosynthesis";"Stigma estolide biosynthesis";"Ether lipid metabolism";"Anandamide biosynthesis I";"2-arachidonoylglycerol biosynthesis";"Depolymerisation of the Nuclear Lamina";"Palmitoyl ethanolamide biosynthesis";"Glycerophospholipid metabolism";"Triglyceride biosynthesis";"Synthesis of PC"
XP_053964378.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053952223.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053962656.1	5	Reactome: R-HSA-1237112;KEGG: 00270+4.2.1.109;Reactome: R-HSA-111458;MetaCyc: PWY-4361;Reactome: R-HSA-9627069	"Methionine salvage pathway";"Cysteine and methionine metabolism";"Formation of apoptosome";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Regulation of the apoptosome activity"
XP_053954660.1	12	Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-6807878;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-381038;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-5620912;Reactome: R-HSA-2132295	"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"COPI-mediated anterograde transport";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"XBP1(S) activates chaperone genes";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"Anchoring of the basal body to the plasma membrane";"MHC class II antigen presentation"
XP_053963270.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053951651.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053967461.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053953382.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_053953367.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053956538.1	5	KEGG: 00520+2.7.1.6;MetaCyc: PWY-6317;MetaCyc: PWY-3821;MetaCyc: PWY-6527;KEGG: 00052+2.7.1.6	"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification";"Stachyose degradation";"Galactose metabolism"
XP_053954518.1	1	Reactome: R-HSA-2468052	"Establishment of Sister Chromatid Cohesion"
XP_053946929.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053953225.1	12	MetaCyc: PWY-7343;KEGG: 00040+2.7.7.9;KEGG: 00052+2.7.7.9;MetaCyc: PWY-3801;KEGG: 00500+2.7.7.9;MetaCyc: PWY-7817;Reactome: R-HSA-173599;KEGG: 00520+2.7.7.9;Reactome: R-HSA-3322077;MetaCyc: PWY-7238;KEGG: 00561+2.7.7.9;MetaCyc: PWY-6527	"UDP-alpha-D-glucose biosynthesis I";"Pentose and glucuronate interconversions";"Galactose metabolism";"Sucrose degradation II (sucrose synthase)";"Starch and sucrose metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Formation of the active cofactor, UDP-glucuronate";"Amino sugar and nucleotide sugar metabolism";"Glycogen synthesis";"Sucrose biosynthesis II";"Glycerolipid metabolism";"Stachyose degradation"
XP_053957513.1	14	MetaCyc: PWY-7411;MetaCyc: PWY-6453;MetaCyc: PWY-7589;MetaCyc: PWY-5981;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;KEGG: 00564+2.3.1.51;MetaCyc: PWY-5667;MetaCyc: PWY-7417;MetaCyc: PWY-8053;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7587;MetaCyc: PWY-8055;MetaCyc: PWY-8051	"Phosphatidate biosynthesis (yeast)";"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Plasmalogen biosynthesis";"Synthesis of PA";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Glycerolipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I"
XP_053946435.1	2	Reactome: R-HSA-212676;Reactome: R-HSA-181429	"Dopamine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle"
XP_053946922.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053945539.1	3	Reactome: R-HSA-156590;Reactome: R-HSA-204174;Reactome: R-HSA-8963684	"Glutathione conjugation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Tyrosine catabolism"
XP_053962447.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_053969940.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053955941.1	4	Reactome: R-HSA-947581;KEGG: 00790+4.1.99.22;KEGG: 00790+4.6.1.17;MetaCyc: PWY-6823	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
XP_053960788.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053961845.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053957663.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
XP_053949825.1	3	Reactome: R-HSA-5423646;Reactome: R-HSA-5579007;KEGG: 00220+3.5.1.14	"Aflatoxin activation and detoxification";"Defective ACY1 causes encephalopathy";"Arginine biosynthesis"
XP_053951702.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053958490.1	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
XP_053959309.1	4	KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803	"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing"
XP_053959343.1	22	Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-6811558;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5358751;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-5673000;Reactome: R-HSA-2500257	"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RAF activation";"Resolution of Sister Chromatid Cohesion"
XP_053961094.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053950991.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_053956708.1	3	MetaCyc: PWY-7803;MetaCyc: PWY-6689;Reactome: R-HSA-6784531	"Trna splicing II";"Trna splicing I";"tRNA processing in the nucleus"
XP_053964294.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053945709.1	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange"
XP_053959302.1	22	Reactome: R-HSA-2500257;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-68877;Reactome: R-HSA-5358751;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-6811558;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5663220	"Resolution of Sister Chromatid Cohesion";"Beta-catenin phosphorylation cascade";"RAF activation";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins"
XP_053948012.1	3	Reactome: R-HSA-1799339;Reactome: R-HSA-9609523;Reactome: R-HSA-1236974	"SRP-dependent cotranslational protein targeting to membrane";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"ER-Phagosome pathway"
XP_053952375.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053952923.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053954510.1	6	Reactome: R-HSA-69473;Reactome: R-HSA-176187;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938	"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)"
XP_053950286.1	10	KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;KEGG: 00430+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-6842;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-4061;MetaCyc: PWY-7112;MetaCyc: PWY-5826;MetaCyc: PWY-7559	"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Taurine and hypotaurine metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification II";"Glutathione metabolism";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Hypoglycin biosynthesis";"Glutathione degradation (DUG pathway"
XP_053963970.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_053946385.1	5	Reactome: R-HSA-73614;KEGG: 00983+2.4.2.3;Reactome: R-HSA-73621;MetaCyc: PWY-5532;KEGG: 00240+2.4.2.3	"Pyrimidine salvage";"Drug metabolism - other enzymes";"Pyrimidine catabolism";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine metabolism"
XP_053945082.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053955164.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_053957857.1	3	KEGG: 00230+1.7.3.3;KEGG: 00232+1.7.3.3;MetaCyc: PWY-5691	"Purine metabolism";"Caffeine metabolism";"Urate conversion to allantoin I"
XP_053953432.1	7	Reactome: R-HSA-73780;Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053946229.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053963583.1	33	Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-168271;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-2467813;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-159230;Reactome: R-HSA-9648025;Reactome: R-HSA-159236;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-168333;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-3301854	"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Separation of Sister Chromatids";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP Dependant Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear Pore Complex (NPC) Disassembly"
XP_053948067.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053962686.1	4	Reactome: R-HSA-983168;Reactome: R-HSA-6802952;Reactome: R-HSA-1632852;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Signaling by BRAF and RAF fusions";"Macroautophagy";"Neutrophil degranulation"
XP_053951637.1	4	MetaCyc: PWY-7822;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902	"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)"
XP_053948346.1	1	MetaCyc: PWY-6938	"NADH repair"
XP_053969733.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053952731.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_053952007.1	2	Reactome: R-HSA-72706;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition"
XP_053969814.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_053951019.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_053952787.1	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053952762.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_053950421.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (q) signalling events";"Peptide ligand-binding receptors"
XP_053962585.1	6	Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702	"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition"
XP_053947907.1	6	Reactome: R-HSA-446199;MetaCyc: PWY-922;KEGG: 00900+4.1.1.33;MetaCyc: PWY-7391;Reactome: R-HSA-2426168;Reactome: R-HSA-191273	"Synthesis of Dolichyl-phosphate";"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Isoprene biosynthesis II (engineered)";"Activation of gene expression by SREBF (SREBP)";"Cholesterol biosynthesis"
XP_053956239.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053947600.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053969674.1	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Activation of RAC1";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053951681.1	9	MetaCyc: PWY-6351;MetaCyc: PWY-8052;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;KEGG: 04070+3.1.4.11;Reactome: R-HSA-1855204;MetaCyc: PWY-6367;Reactome: R-HSA-416476;Reactome: R-HSA-112043	"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"2-arachidonoylglycerol biosynthesis";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol-5-phosphate metabolism";"G alpha (q) signalling events";"PLC beta mediated events"
XP_053953359.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1660661	"Neutrophil degranulation";"Sphingolipid de novo biosynthesis"
XP_053957572.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053958920.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_053952121.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053950327.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053945230.1	4	Reactome: R-HSA-2214320;Reactome: R-HSA-1474228;Reactome: R-HSA-2243919;Reactome: R-HSA-1650814	"Anchoring fibril formation";"Degradation of the extracellular matrix";"Crosslinking of collagen fibrils";"Collagen biosynthesis and modifying enzymes"
XP_053948539.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053958928.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_053969854.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053957831.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053950448.1	2	Reactome: R-HSA-73621;Reactome: R-HSA-500753	"Pyrimidine catabolism";"Pyrimidine biosynthesis"
XP_053948073.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053948532.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053963572.1	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
XP_053963033.1	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
XP_053961483.1	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
XP_053954030.1	1	Reactome: R-HSA-191273	"Cholesterol biosynthesis"
XP_053951052.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_053954259.1	6	Reactome: R-HSA-983712;Reactome: R-HSA-6798695;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"Ion channel transport";"Neutrophil degranulation";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1"
XP_053945696.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053958241.1	11	Reactome: R-HSA-2029485;MetaCyc: PWY-8055;MetaCyc: PWY-8052;MetaCyc: PWY-8051;MetaCyc: PWY-8053;KEGG: 00561+3.1.3.4;MetaCyc: PWY-6453;KEGG: 00564+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;KEGG: 00565+3.1.3.4	"Role of phospholipids in phagocytosis";"Palmitoyl ethanolamide biosynthesis";"2-arachidonoylglycerol biosynthesis";"Anandamide biosynthesis I";"Anandamide biosynthesis II";"Glycerolipid metabolism";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Ether lipid metabolism"
XP_053946528.1	4	KEGG: 00513+2.4.1.260;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.260;Reactome: R-HSA-4720489	"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Defective ALG12 causes ALG12-CDG (CDG-1g)"
XP_053954919.1	9	Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-73776;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events"
XP_053969549.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_053962035.1	2	Reactome: R-HSA-5658442;Reactome: R-HSA-6802953	"Regulation of RAS by GAPs";"RAS signaling downstream of NF1 loss-of-function variants"
XP_053958220.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-5663220	"Signaling by ROBO receptors";"RHO GTPases Activate Formins"
XP_053969542.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053969807.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_053961126.1	6	MetaCyc: PWY-5664;MetaCyc: PWY-7442;KEGG: 00790+4.2.3.12;MetaCyc: PWY-5663;MetaCyc: PWY-6983;Reactome: R-HSA-1474151	"Erythro-tetrahydrobiopterin biosynthesis II";"Drosopterin and aurodrosopterin biosynthesis";"Folate biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Threo-tetrahydrobiopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"
XP_053955263.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_053945847.1	3	Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916	"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium"
XP_053958139.1	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
XP_053946852.1	11	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-163680;KEGG: 04714+2.7.11.1;Reactome: R-HSA-9614657;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-380972	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"AMPK inhibits chREBP transcriptional activation activity";"Thermogenesis";"FOXO-mediated transcription of cell death genes";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_053957356.1	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
XP_053952673.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_053946405.1	9	MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5789;MetaCyc: PWY-5743;MetaCyc: PWY-7115;MetaCyc: PWY-5744;Reactome: R-HSA-1475029;MetaCyc: PWY-7117;MetaCyc: PWY-241	"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Glyoxylate assimilation";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type"
XP_053966297.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_053955195.1	7	KEGG: 00360+1.14.16.1;MetaCyc: PWY-7158;MetaCyc: PWY-6134;KEGG: 00790+1.14.16.1;KEGG: 00400+1.14.16.1;Reactome: R-HSA-8964208;Reactome: R-HSA-2160456	"Phenylalanine metabolism";"L-phenylalanine degradation V";"L-tyrosine biosynthesis IV";"Folate biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Phenylalanine metabolism";"Phenylketonuria"
XP_053969494.1	26	Reactome: R-HSA-6807878;Reactome: R-HSA-8852276;Reactome: R-HSA-389977;Reactome: R-HSA-5663220;Reactome: R-HSA-983189;Reactome: R-HSA-190861;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-389960;Reactome: R-HSA-437239;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-2132295;Reactome: R-HSA-1445148;Reactome: R-HSA-8955332;Reactome: R-HSA-5626467;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Post-chaperonin tubulin folding pathway";"RHO GTPases Activate Formins";"Kinesins";"Gap junction assembly";"Separation of Sister Chromatids";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Recycling pathway of L1";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Cilium Assembly";"Aggrephagy";"MHC class II antigen presentation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases activate IQGAPs";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053951847.1	4	Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-69205;Reactome: R-HSA-68962	"Unwinding of DNA";"Activation of ATR in response to replication stress";"G1/S-Specific Transcription";"Activation of the pre-replicative complex"
XP_053970177.1	2	Reactome: R-HSA-190873;Reactome: R-HSA-399719	"Gap junction degradation";"Trafficking of AMPA receptors"
XP_053955977.1	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
XP_053951122.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053962715.1	23	Reactome: R-HSA-8964315;Reactome: R-HSA-456926;Reactome: R-HSA-418594;Reactome: R-HSA-8964616;Reactome: R-HSA-428930;Reactome: R-HSA-500657;Reactome: R-HSA-420092;Reactome: R-HSA-400042;Reactome: R-HSA-432040;Reactome: R-HSA-418592;Reactome: R-HSA-392170;Reactome: R-HSA-381676;Reactome: R-HSA-392851;Reactome: R-HSA-416482;Reactome: R-HSA-6814122;Reactome: R-HSA-9009391;Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-4086398;Reactome: R-HSA-418555;Reactome: R-HSA-202040;Reactome: R-HSA-418217;Reactome: R-HSA-392451	"G beta:gamma signalling through BTK";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (i) signalling events";"G beta:gamma signalling through CDC42";"Thromboxane signalling through TP receptor";"Presynaptic function of Kainate receptors";"Glucagon-type ligand receptors";"Adrenaline,noradrenaline inhibits insulin secretion";"Vasopressin regulates renal water homeostasis via Aquaporins";"ADP signalling through P2Y purinoceptor 1";"ADP signalling through P2Y purinoceptor 12";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Prostacyclin signalling through prostacyclin receptor";"G alpha (12/13) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Extra-nuclear estrogen signaling";"G alpha (q) signalling events";"G alpha (z) signalling events";"Ca2+ pathway";"G alpha (s) signalling events";"G-protein activation";"G beta:gamma signalling through PLC beta";"G beta:gamma signalling through PI3Kgamma"
XP_053951129.1	10	KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-4061;MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;MetaCyc: PWY-6842;MetaCyc: PWY-4041;KEGG: 00460+2.3.2.2;MetaCyc: PWY-5826;MetaCyc: PWY-7559;MetaCyc: PWY-7112	"Glutathione metabolism";"Glutathione-mediated detoxification I";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Glutathione-mediated detoxification II";"Gamma-glutamyl cycle";"Cyanoamino acid metabolism";"Hypoglycin biosynthesis";"Glutathione degradation (DUG pathway";"4-hydroxy-2-nonenal detoxification"
XP_053969811.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_053946683.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053963620.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053953190.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053966936.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053948908.1	2	Reactome: R-HSA-5218920;Reactome: R-HSA-418990	"VEGFR2 mediated vascular permeability";"Adherens junctions interactions"
XP_053945476.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053970163.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_053946812.1	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
XP_053957316.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053969013.1	16	Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-2559585;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-9029569	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"Oncogene Induced Senescence";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_053956141.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_053953855.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053951761.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053954750.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053959361.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053948900.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-168138	"Factors involved in megakaryocyte development and platelet production";"Toll Like Receptor 9 (TLR9) Cascade"
XP_053958722.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_053957620.1	1	Reactome: R-HSA-111957	"Cam-PDE 1 activation"
XP_053945761.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation"
XP_053958729.1	5	MetaCyc: PWY-5514;Reactome: R-HSA-70171;MetaCyc: PWY-6906;MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6	"UDP-N-acetyl-D-galactosamine biosynthesis II";"Glycolysis";"Chitin derivatives degradation";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism"
XP_053952689.1	1	Reactome: R-HSA-5689896	"Ovarian tumor domain proteases"
XP_053967190.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-77595;Reactome: R-HSA-159231;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway"
XP_053962363.1	2	Reactome: R-HSA-8986944;Reactome: R-HSA-203927	"Transcriptional Regulation by MECP2";"MicroRNA (miRNA) biogenesis"
XP_053954718.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053952445.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053969851.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053962471.1	2	Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58	"Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis"
XP_053955850.1	3	KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Triglyceride biosynthesis";"Glycerol degradation I"
XP_053967815.1	4	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-3769402	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex"
XP_053945732.1	5	KEGG: 00760+2.7.7.18;MetaCyc: PWY-5381;MetaCyc: PWY-5653;Reactome: R-HSA-196807;MetaCyc: PWY-7761	"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate metabolism";"NAD salvage pathway II (PNC IV cycle)"
XP_053957713.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_053959339.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053952268.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053946679.1	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
XP_053967576.1	5	Reactome: R-HSA-75896;Reactome: R-HSA-9033500;KEGG: 00565+2.5.1.26;Reactome: R-HSA-9033241;MetaCyc: PWY-7782	"Plasmalogen biosynthesis";"TYSND1 cleaves peroxisomal proteins";"Ether lipid metabolism";"Peroxisomal protein import";"Plasmalogen biosynthesis"
XP_053956964.1	4	Reactome: R-HSA-68884;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"Mitotic Telophase/Cytokinesis";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053957834.1	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
XP_053945739.1	4	Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-427389	"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"
XP_053952853.1	4	KEGG: 00250+1.4.1.14;Reactome: R-HSA-73621;MetaCyc: PWY-6963;KEGG: 00910+1.4.1.14	"Alanine, aspartate and glutamate metabolism";"Pyrimidine catabolism";"Ammonia assimilation cycle I";"Nitrogen metabolism"
XP_053964956.1	6	Reactome: R-HSA-9022537;Reactome: R-HSA-1989781;Reactome: R-HSA-9609690;Reactome: R-HSA-9029569;Reactome: R-HSA-3214815;Reactome: R-HSA-9022692	"Loss of MECP2 binding ability to the NCoR/SMRT complex";"PPARA activates gene expression";"HCMV Early Events";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"HDACs deacetylate histones";"Regulation of MECP2 expression and activity"
XP_053947251.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053958888.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_053949955.1	2	Reactome: R-HSA-1483166;Reactome: R-HSA-1483148	"Synthesis of PA";"Synthesis of PG"
XP_053951732.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_053947911.1	2	KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7	"Pyruvate metabolism";"Aminobenzoate degradation"
XP_053948739.1	4	KEGG: 00970+6.1.1.6;Reactome: R-HSA-379716;Reactome: R-HSA-2408522;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation"
XP_053957003.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053954008.1	4	Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-5625970;Reactome: R-HSA-2132295	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"RHO GTPases activate KTN1";"MHC class II antigen presentation"
XP_053950370.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053948732.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_053945654.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053946130.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053951208.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053961706.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053970050.1	4	MetaCyc: PWY-4261;KEGG: 00040+2.7.1.17;Reactome: R-HSA-5661270;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Pentose and glucuronate interconversions";"Formation of xylulose-5-phosphate";"Glycerolipid metabolism"
XP_053951654.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
XP_053946889.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053954829.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053952081.1	12	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9619483;Reactome: R-HSA-380972;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 04151+2.7.11.1;Reactome: R-HSA-1632852;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"Regulation of TP53 Activity through Phosphorylation";"Human cytomegalovirus infection";"Activation of AMPK downstream of NMDARs";"Energy dependent regulation of mTOR by LKB1-AMPK";"Human papillomavirus infection";"TP53 Regulates Metabolic Genes";"PI3K-Akt signaling pathway";"Macroautophagy";"mTOR signaling pathway";"Relaxin signaling pathway"
XP_053946882.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053970232.1	7	Reactome: R-HSA-2122947;Reactome: R-HSA-212436;Reactome: R-HSA-2644606;Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-2173796;Reactome: R-HSA-2894862	"NOTCH1 Intracellular Domain Regulates Transcription";"Generic Transcription Pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053946653.1	3	Reactome: R-HSA-2468052;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257	"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion"
XP_053969742.1	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
XP_053961086.1	8	Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-6804115;Reactome: R-HSA-5620912	"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Anchoring of the basal body to the plasma membrane"
XP_053949285.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053946071.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_053958963.1	2	Reactome: R-HSA-446203;Reactome: R-HSA-1799339	"Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053969168.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053957497.1	2	Reactome: R-HSA-163282;Reactome: R-HSA-2151201	"Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis"
XP_053961303.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053970018.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053961349.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053966427.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053961342.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053946873.1	18	MetaCyc: PWY-5695;MetaCyc: PWY-7179-1;MetaCyc: PWY-4202;MetaCyc: PWY-6608;Reactome: R-HSA-73621;KEGG: 00240+2.4.2.1;MetaCyc: PWY-7179;KEGG: 00760+2.4.2.1;MetaCyc: PWY-5532;MetaCyc: PWY-6609;MetaCyc: PWY-6620;KEGG: 00983+2.4.2.3;KEGG: 00230+2.4.2.1;MetaCyc: PWY-6644;KEGG: 00240+2.4.2.3;MetaCyc: PWY-6611;Reactome: R-HSA-73614;MetaCyc: PWY-6627	"Inosine 5'-phosphate degradation";"Purine deoxyribonucleosides degradation II";"Arsenate detoxification I (mammalian)";"Guanosine nucleotides degradation III";"Pyrimidine catabolism";"Pyrimidine metabolism";"Purine deoxyribonucleosides degradation I";"Nicotinate and nicotinamide metabolism";"Nucleoside and nucleotide degradation (archaea)";"Adenine and adenosine salvage III";"Guanine and guanosine salvage";"Drug metabolism - other enzymes";"Purine metabolism";"Fluoroacetate and fluorothreonine biosynthesis";"Pyrimidine metabolism";"Adenine and adenosine salvage V";"Pyrimidine salvage";"Salinosporamide A biosynthesis"
XP_053958810.1	6	Reactome: R-HSA-1650814;Reactome: R-HSA-2022090;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490	"Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Collagen chain trimerization";"Collagen degradation"
XP_053960982.1	5	KEGG: 00760+6.3.4.21;Reactome: R-HSA-1368108;MetaCyc: PWY-5381;Reactome: R-HSA-197264;Reactome: R-HSA-6798695	"Nicotinate and nicotinamide metabolism";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Pyridine nucleotide cycling (plants)";"Nicotinamide salvaging";"Neutrophil degranulation"
XP_053969533.1	12	KEGG: 00450+4.4.1.13;Reactome: R-HSA-71240;MetaCyc: PWY-601;MetaCyc: PWY-801;KEGG: 00380+2.6.1.7;MetaCyc: PWY-7901;MetaCyc: PWY-6842;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6309;MetaCyc: PWY-1187;MetaCyc: PWY-6936;MetaCyc: PWY-2821	"Selenocompound metabolism";"Tryptophan catabolism";"Glucosinolate biosynthesis from tryptophan";"Homocysteine and cysteine interconversion";"Tryptophan metabolism";"Glucosinolate biosynthesis from tyrosine";"Glutathione-mediated detoxification II";"Cysteine and methionine metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glucosinolate biosynthesis from homomethionine";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from phenylalanine"
XP_053952531.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053966340.1	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
XP_053960989.1	5	KEGG: 00760+6.3.4.21;Reactome: R-HSA-197264;Reactome: R-HSA-1368108;MetaCyc: PWY-5381;Reactome: R-HSA-6798695	"Nicotinate and nicotinamide metabolism";"Nicotinamide salvaging";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Pyridine nucleotide cycling (plants)";"Neutrophil degranulation"
XP_053960518.1	42	Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-2559580;Reactome: R-HSA-912446;Reactome: R-HSA-9018519;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-5334118;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-3214858;Reactome: R-HSA-73728;Reactome: R-HSA-3214815;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-427413;Reactome: R-HSA-2299718;Reactome: R-HSA-3214842;Reactome: R-HSA-110330;Reactome: R-HSA-69473;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-110331;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-5693607;Reactome: R-HSA-5578749;Reactome: R-HSA-427359	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"Oxidative Stress Induced Senescence";"Meiotic recombination";"Estrogen-dependent gene expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Meiotic synapsis";"Packaging Of Telomere Ends";"DNA methylation";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RMTs methylate histone arginines";"RNA Polymerase I Promoter Opening";"HDACs deacetylate histones";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"NoRC negatively regulates rRNA expression";"Condensation of Prophase Chromosomes";"HDMs demethylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"G2/M DNA damage checkpoint";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"Cleavage of the damaged purine";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Processing of DNA double-strand break ends";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression"
XP_053956902.1	2	Reactome: R-HSA-162588;Reactome: R-HSA-917729	"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)"
XP_053963783.1	15	MetaCyc: PWY-2221;MetaCyc: PWY-8004;MetaCyc: PWY-7383;MetaCyc: PWY-5723;KEGG: 00010+2.7.1.40;Reactome: R-HSA-70171;MetaCyc: PWY-7218;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6901;MetaCyc: PWY-6142;MetaCyc: PWY-1042;MetaCyc: PWY-6886;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40;MetaCyc: PWY-7003	"Entner-Doudoroff pathway III (semi-phosphorylative)";"Entner-Doudoroff pathway I";"Anaerobic energy metabolism (invertebrates, cytosol)";"Rubisco shunt";"Glycolysis / Gluconeogenesis";"Glycolysis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism";"Glycerol degradation to butanol"
XP_053954780.1	29	Reactome: R-HSA-167246;Reactome: R-HSA-5696395;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-73772;Reactome: R-HSA-167161;Reactome: R-HSA-5696400;Reactome: R-HSA-112382;Reactome: R-HSA-72086;Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-6781823;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-6781827;Reactome: R-HSA-73762;Reactome: R-HSA-6782135;Reactome: R-HSA-427413;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-167152;Reactome: R-HSA-167160	"Tat-mediated elongation of the HIV-1 transcript";"Formation of Incision Complex in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase I Promoter Escape";"HIV Transcription Initiation";"Dual Incision in GG-NER";"Formation of RNA Pol II elongation complex";"mRNA Capping";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Transcription Initiation";"Dual incision in TC-NER";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection"
XP_053948122.1	10	MetaCyc: PWY-5826;MetaCyc: PWY-7559;MetaCyc: PWY-7112;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-4061;MetaCyc: PWY-6842;KEGG: 00430+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4041;KEGG: 00460+2.3.2.2	"Hypoglycin biosynthesis";"Glutathione degradation (DUG pathway";"4-hydroxy-2-nonenal detoxification";"Glutathione metabolism";"Glutathione-mediated detoxification I";"Glutathione-mediated detoxification II";"Taurine and hypotaurine metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Gamma-glutamyl cycle";"Cyanoamino acid metabolism"
XP_053945908.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053961635.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053952096.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053960660.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053950994.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_053951200.1	18	Reactome: R-HSA-1482801;Reactome: R-HSA-1483166;Reactome: R-HSA-1482839;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482925;Reactome: R-HSA-1482788;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-6803;Reactome: R-HSA-1482922;KEGG: 00592+3.1.1.4	"Acyl chain remodelling of PS";"Synthesis of PA";"Acyl chain remodelling of PE";"Glycerophospholipid metabolism";"Acyl chain remodelling of PG";"Acyl chain remodelling of PC";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"Ether lipid metabolism";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PI";"alpha-Linolenic acid metabolism"
XP_053968106.1	6	Reactome: R-HSA-390247;Reactome: R-HSA-2046105;Reactome: R-HSA-9603798;Reactome: R-HSA-5684045;Reactome: R-HSA-1369062;Reactome: R-HSA-2046106	"Beta-oxidation of very long chain fatty acids";"Linoleic acid (LA) metabolism";"Class I peroxisomal membrane protein import";"Defective ABCD1 causes adrenoleukodystrophy (ALD)";"ABC transporters in lipid homeostasis";"alpha-linolenic acid (ALA) metabolism"
XP_053946138.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387	"Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling"
XP_053961091.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053957772.1	28	Reactome: R-HSA-5656121;Reactome: R-HSA-5696400;Reactome: R-HSA-6804756;Reactome: R-HSA-110314;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-5651801;Reactome: R-HSA-69166;Reactome: R-HSA-5358565;Reactome: R-HSA-110312;Reactome: R-HSA-6782135;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-110320;Reactome: R-HSA-68962;Reactome: R-HSA-3371511;Reactome: R-HSA-176187;Reactome: R-HSA-5655862;Reactome: R-HSA-5696395;Reactome: R-HSA-5358606;Reactome: R-HSA-6782210;Reactome: R-HSA-174437;Reactome: R-HSA-3371453;Reactome: R-HSA-5685942;Reactome: R-HSA-6783310;Reactome: R-HSA-912446	"Translesion synthesis by POLI";"Dual Incision in GG-NER";"Regulation of TP53 Activity through Phosphorylation";"Recognition of DNA damage by PCNA-containing replication complex";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion synthesis by REV1";"Dual incision in TC-NER";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"Translesion Synthesis by POLH";"Activation of the pre-replicative complex";"HSF1 activation";"Activation of ATR in response to replication stress";"Translesion synthesis by POLK";"Formation of Incision Complex in GG-NER";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Removal of the Flap Intermediate from the C-strand";"Regulation of HSF1-mediated heat shock response";"HDR through Homologous Recombination (HRR)";"Fanconi Anemia Pathway";"Meiotic recombination"
XP_053950378.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053954000.1	3	Reactome: R-HSA-72165;Reactome: R-HSA-191859;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"snRNP Assembly";"mRNA Splicing - Major Pathway"
XP_053963049.1	40	MetaCyc: PWY-7654;MetaCyc: PWY-7094;KEGG: 00640+4.2.1.17;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;MetaCyc: PWY-7606;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00410+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-7007;KEGG: 00592+4.2.1.17;MetaCyc: PWY-6883;MetaCyc: PWY-6863;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6945;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;MetaCyc: PWY-5789;MetaCyc: PWY-7401;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;MetaCyc: PWY-6583;MetaCyc: PWY-5177;MetaCyc: PWY-6944;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;MetaCyc: PWY-5138;MetaCyc: PWY-7216;MetaCyc: PWY-7726;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;MetaCyc: PWY-7778;KEGG: 00623+1.1.1.35;KEGG: 00627+4.2.1.17;MetaCyc: PWY-5109;KEGG: 00360+4.2.1.17;MetaCyc: PWY-5136;KEGG: 00071+4.2.1.17+1.1.1.35	"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Fatty acid salvage";"Propanoate metabolism";"Benzoate degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Lysine degradation";"beta-Alanine metabolism";"Butanoate metabolism";"Methyl ketone biosynthesis (engineered)";"alpha-Linolenic acid metabolism";"Pyruvate fermentation to butanol II (engineered)";"Pyruvate fermentation to hexanol (engineered)";"Limonene and pinene degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Fatty acid elongation";"Valine, leucine and isoleucine degradation";"Benzoyl-coa degradation I (aerobic)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Caprolactam degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Pyruvate fermentation to butanol I";"Glutaryl-coa degradation";"Androstenedione degradation";"Carbon fixation pathways in prokaryotes";"Methyl tert-butyl ether degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Tryptophan metabolism";"Geraniol degradation";"Spodoptera littoralis pheromone biosynthesis";"2-methylpropene degradation";"Toluene degradation";"Aminobenzoate degradation";"Fermentation to 2-methylbutanoate";"Phenylalanine metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation"
XP_053963003.1	7	KEGG: 04070+3.1.3.36;KEGG: 00562+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1660499;Reactome: R-HSA-1855183;Reactome: R-HSA-8856828;Reactome: R-HSA-1855204	"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of PIPs at the plasma membrane";"Synthesis of IP2, IP, and Ins in the cytosol";"Clathrin-mediated endocytosis";"Synthesis of IP3 and IP4 in the cytosol"
XP_053946613.1	4	MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32	"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism"
XP_053945874.1	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
XP_053951874.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_053952883.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053952569.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053958723.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_053968825.1	6	KEGG: 05235+3.1.3.16;Reactome: R-HSA-2173788;Reactome: R-HSA-400253;Reactome: R-HSA-163560;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Downregulation of TGF-beta receptor signaling";"Circadian Clock";"Triglyceride catabolism";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053962369.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053970070.1	6	Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-69052;Reactome: R-HSA-68962	"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"Unwinding of DNA";"Assembly of the pre-replicative complex";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex"
XP_053955680.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053955987.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_053953403.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053950350.1	18	MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482839;Reactome: R-HSA-1482801;MetaCyc: PWY-7417;MetaCyc: PWY-8053;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925	"Plasmalogen degradation";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PE";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG"
XP_053970162.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_053945336.1	2	Reactome: R-HSA-380095;Reactome: R-HSA-416476	"Tachykinin receptors bind tachykinins";"G alpha (q) signalling events"
XP_053964400.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053946968.1	1	Reactome: R-HSA-5649702	"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"
XP_053969012.1	16	Reactome: R-HSA-8934593;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-2559585	"Regulation of RUNX1 Expression and Activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"Oncogene Induced Senescence"
XP_053946734.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_053970169.1	3	MetaCyc: PWY-7942;KEGG: 00480+4.3.2.7;Reactome: R-HSA-174403	"5-oxo-L-proline metabolism";"Glutathione metabolism";"Glutathione synthesis and recycling"
XP_053959736.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053969019.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053958326.1	42	Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-5693607;Reactome: R-HSA-110331;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-2299718;Reactome: R-HSA-69473;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-427413;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-5334118;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-912446;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-212300;Reactome: R-HSA-2559580;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-9018519	"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Processing of DNA double-strand break ends";"Cleavage of the damaged purine";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Condensation of Prophase Chromosomes";"G2/M DNA damage checkpoint";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"NoRC negatively regulates rRNA expression";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"Packaging Of Telomere Ends";"Meiotic synapsis";"DNA methylation";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"Meiotic recombination";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PRC2 methylates histones and DNA";"Oxidative Stress Induced Senescence";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Estrogen-dependent gene expression"
XP_053953097.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053958917.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_053958568.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053961835.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_053969930.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053962331.1	4	Reactome: R-HSA-71737;MetaCyc: PWY-7807;MetaCyc: PWY-7805;KEGG: 00190+3.6.1.1	"Pyrophosphate hydrolysis";"Glyphosate degradation III";"(aminomethyl)phosphonate degradation";"Oxidative phosphorylation"
XP_053956540.1	5	MetaCyc: PWY-6527;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6317;KEGG: 00520+2.7.1.6	"Stachyose degradation";"Galactose metabolism";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism"
XP_053947173.1	9	MetaCyc: PWY-5789;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-5744;MetaCyc: PWY-7117;Reactome: R-HSA-1475029;MetaCyc: PWY-241	"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, NADP-ME type"
XP_053957712.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053945733.1	5	KEGG: 00760+2.7.7.18;MetaCyc: PWY-5653;MetaCyc: PWY-5381;Reactome: R-HSA-196807;MetaCyc: PWY-7761	"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)";"Nicotinate metabolism";"NAD salvage pathway II (PNC IV cycle)"
XP_053952405.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053946260.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053952852.1	4	KEGG: 00250+1.4.1.14;KEGG: 00910+1.4.1.14;Reactome: R-HSA-73621;MetaCyc: PWY-6963	"Alanine, aspartate and glutamate metabolism";"Nitrogen metabolism";"Pyrimidine catabolism";"Ammonia assimilation cycle I"
XP_053959472.1	6	Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604	"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA"
XP_053954184.1	14	Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-167152;Reactome: R-HSA-167243	"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery"
XP_053946124.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_053951542.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_053967685.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_053948240.1	1	KEGG: 04150+2.7.11.24	"mTOR signaling pathway"
XP_053951549.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-1268020	"Citric acid cycle (TCA cycle)";"Mitochondrial protein import"
XP_053951486.1	5	Reactome: R-HSA-196025;Reactome: R-HSA-3928665;Reactome: R-HSA-190873;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells";"Gap junction degradation";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053946557.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053955262.1	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_053955287.1	5	KEGG: 00380+1.2.4.2;MetaCyc: PWY-5084;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2	"Tryptophan metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"Citrate cycle (TCA cycle)"
XP_053946853.1	11	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-9614657;KEGG: 04151+2.7.11.1;Reactome: R-HSA-163680;KEGG: 05165+2.7.11.1;Reactome: R-HSA-380972;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6804756	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"FOXO-mediated transcription of cell death genes";"PI3K-Akt signaling pathway";"AMPK inhibits chREBP transcriptional activation activity";"Human papillomavirus infection";"Energy dependent regulation of mTOR by LKB1-AMPK";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Regulation of TP53 Activity through Phosphorylation"
XP_053950105.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053956548.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_053950525.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053946682.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053954622.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_053958217.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-5663220	"Signaling by ROBO receptors";"RHO GTPases Activate Formins"
XP_053946689.1	5	Reactome: R-HSA-901042;Reactome: R-HSA-532668;Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-879415	"Calnexin/calreticulin cycle";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Advanced glycosylation endproduct receptor signaling"
XP_053969230.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_053951854.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053947167.1	9	MetaCyc: PWY-7902;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;MetaCyc: PWY-7385;KEGG: 00564+1.1.1.94;KEGG: 00564+1.1.1.8;MetaCyc: PWY-6118;MetaCyc: PWY-5667	"Glucosylglycerol biosynthesis";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"1,3-propanediol biosynthesis (engineered)";"Glycerophospholipid metabolism";"Glycerophospholipid metabolism";"Glycerol-3-phosphate shuttle";"CDP-diacylglycerol biosynthesis I"
XP_053967442.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_053958650.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_053963601.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_053967449.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053948416.1	3	KEGG: 00860+1.16.3.1;Reactome: R-HSA-1268020;Reactome: R-HSA-1362409	"Porphyrin and chlorophyll metabolism";"Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis"
XP_053959506.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
XP_053946011.1	57	Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-5658442;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-6798695;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-4608870;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-174184	"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Regulation of RAS by GAPs";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Neutrophil degranulation";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Asymmetric localization of PCP proteins";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"Degradation of AXIN";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"Neddylation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
XP_053946504.1	42	Reactome: R-HSA-977225;Reactome: R-HSA-5693571;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-5334118;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-3214815;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-73728;Reactome: R-HSA-3214858;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-2559580;Reactome: R-HSA-912446;Reactome: R-HSA-9018519;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-110331;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-5693607;Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-427413;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-2299718;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638	"Amyloid fiber formation";"Nonhomologous End-Joining (NHEJ)";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"DNA methylation";"Meiotic synapsis";"Packaging Of Telomere Ends";"HDACs deacetylate histones";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Opening";"RMTs methylate histone arginines";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"Oxidative Stress Induced Senescence";"Meiotic recombination";"Estrogen-dependent gene expression";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Cleavage of the damaged purine";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Processing of DNA double-strand break ends";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"Condensation of Prophase Chromosomes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"HCMV Late Events";"SUMOylation of chromatin organization proteins"
XP_053956949.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053970157.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950380.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053960279.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053945948.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_053948397.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053952653.1	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
XP_053946872.1	18	MetaCyc: PWY-7179;KEGG: 00760+2.4.2.1;KEGG: 00240+2.4.2.1;MetaCyc: PWY-6608;Reactome: R-HSA-73621;MetaCyc: PWY-4202;MetaCyc: PWY-7179-1;MetaCyc: PWY-5695;MetaCyc: PWY-6609;MetaCyc: PWY-5532;KEGG: 00230+2.4.2.1;MetaCyc: PWY-6644;KEGG: 00983+2.4.2.3;MetaCyc: PWY-6620;MetaCyc: PWY-6627;Reactome: R-HSA-73614;MetaCyc: PWY-6611;KEGG: 00240+2.4.2.3	"Purine deoxyribonucleosides degradation I";"Nicotinate and nicotinamide metabolism";"Pyrimidine metabolism";"Guanosine nucleotides degradation III";"Pyrimidine catabolism";"Arsenate detoxification I (mammalian)";"Purine deoxyribonucleosides degradation II";"Inosine 5'-phosphate degradation";"Adenine and adenosine salvage III";"Nucleoside and nucleotide degradation (archaea)";"Purine metabolism";"Fluoroacetate and fluorothreonine biosynthesis";"Drug metabolism - other enzymes";"Guanine and guanosine salvage";"Salinosporamide A biosynthesis";"Pyrimidine salvage";"Adenine and adenosine salvage V";"Pyrimidine metabolism"
XP_053962226.1	57	Reactome: R-HSA-382556;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-174178;Reactome: R-HSA-4608870;Reactome: R-HSA-450408;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-6798695;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-202424;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-5676590;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-9604323;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-4641257	"ABC-family proteins mediated transport";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Asymmetric localization of PCP proteins";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Neutrophil degranulation";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Downstream TCR signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"NIK-->noncanonical NF-kB signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Neddylation";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"Negative regulation of NOTCH4 signaling";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Degradation of AXIN"
XP_053955878.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053960983.1	5	KEGG: 00760+6.3.4.21;MetaCyc: PWY-5381;Reactome: R-HSA-1368108;Reactome: R-HSA-197264;Reactome: R-HSA-6798695	"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinamide salvaging";"Neutrophil degranulation"
XP_053969532.1	12	MetaCyc: PWY-6936;MetaCyc: PWY-2821;MetaCyc: PWY-1187;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6309;MetaCyc: PWY-6842;MetaCyc: PWY-7901;KEGG: 00380+2.6.1.7;MetaCyc: PWY-601;MetaCyc: PWY-801;Reactome: R-HSA-71240;KEGG: 00450+4.4.1.13	"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from phenylalanine";"Glucosinolate biosynthesis from homomethionine";"Cysteine and methionine metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glutathione-mediated detoxification II";"Glucosinolate biosynthesis from tyrosine";"Tryptophan metabolism";"Glucosinolate biosynthesis from tryptophan";"Homocysteine and cysteine interconversion";"Tryptophan catabolism";"Selenocompound metabolism"
XP_053952071.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053946879.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053969539.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053949136.1	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
XP_053969651.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_053948486.1	2	Reactome: R-HSA-8953750;Reactome: R-HSA-389957	"Transcriptional Regulation by E2F6";"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053952889.1	4	Reactome: R-HSA-72187;Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72163	"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway"
XP_053954021.1	3	Reactome: R-HSA-4085001;KEGG: 00540+2.7.7.38;MetaCyc: PWY-1269	"Sialic acid metabolism";"Lipopolysaccharide biosynthesis";"CMP-3-deoxy-D-manno-octulosonate biosynthesis"
XP_053963828.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053946081.1	4	Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex"
XP_053952563.1	1	Reactome: R-HSA-419771	"Opsins"
XP_053953794.1	14	MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-5981;MetaCyc: PWY-7411	"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)"
XP_053955904.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053964276.1	4	Reactome: R-HSA-446193;Reactome: R-HSA-4720454;KEGG: 00513+2.4.1.261;KEGG: 00510+2.4.1.259+2.4.1.261	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG9 causes ALG9-CDG (CDG-1l)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
XP_053947112.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053950438.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053945221.1	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
XP_053963002.1	7	Reactome: R-HSA-8856828;Reactome: R-HSA-1855204;MetaCyc: PWY-6368;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1855183;Reactome: R-HSA-1660499	"Clathrin-mediated endocytosis";"Synthesis of IP3 and IP4 in the cytosol";"3-phosphoinositide degradation";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the plasma membrane"
XP_053951240.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053946612.1	4	MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32	"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism"
XP_053960979.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053958931.1	2	KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7	"Pyruvate metabolism";"Aminobenzoate degradation"
XP_053954527.1	6	Reactome: R-HSA-9033241;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;KEGG: 00630+1.11.1.6;Reactome: R-HSA-6798695	"Peroxisomal protein import";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"Glyoxylate and dicarboxylate metabolism";"Neutrophil degranulation"
XP_053946587.1	1	Reactome: R-HSA-1169408	"ISG15 antiviral mechanism"
XP_053955257.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_053951456.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053955568.1	7	Reactome: R-HSA-264870;Reactome: R-HSA-445095;Reactome: R-HSA-373753;Reactome: R-HSA-6807878;Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-6798695	"Caspase-mediated cleavage of cytoskeletal proteins";"Interaction between L1 and Ankyrins";"Nephrin family interactions";"COPI-mediated anterograde transport";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"Neutrophil degranulation"
XP_053966166.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053955326.1	3	Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067	"Glycogen synthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)"
XP_053954823.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053962317.1	1	Reactome: R-HSA-1483255	"PI Metabolism"
XP_053953516.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053957002.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053960111.1	44	Reactome: R-HSA-9634638;Reactome: R-HSA-6802952;Reactome: R-HSA-5654733;Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-881907;Reactome: R-HSA-5674499;Reactome: R-HSA-445144;Reactome: R-HSA-2871796;Reactome: R-HSA-879415;Reactome: R-HSA-170968;Reactome: R-HSA-8940973;Reactome: R-HSA-2559580;Reactome: R-HSA-198753;Reactome: R-HSA-9627069;Reactome: R-HSA-74749;Reactome: R-HSA-456926;Reactome: R-HSA-5674135;Reactome: R-HSA-2559582;Reactome: R-HSA-5668599;Reactome: R-HSA-3371453;Reactome: R-HSA-5654732;Reactome: R-HSA-6811558;KEGG: 04150+2.7.11.24;Reactome: R-HSA-8939211;Reactome: R-HSA-1295596;Reactome: R-HSA-450341;Reactome: R-HSA-202670;Reactome: R-HSA-2559585;Reactome: R-HSA-8943724;Reactome: R-HSA-9635465;Reactome: R-HSA-2029482;Reactome: R-HSA-6802955;Reactome: R-HSA-5675221;Reactome: R-HSA-112409;Reactome: R-HSA-162658;Reactome: R-HSA-5663213;Reactome: R-HSA-5654726;Reactome: R-HSA-444257;Reactome: R-HSA-9649948;Reactome: R-HSA-6802948;Reactome: R-HSA-5654727;Reactome: R-HSA-982772;Reactome: R-HSA-6802946	"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Signaling by BRAF and RAF fusions";"Negative regulation of FGFR4 signaling";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"Gastrin-CREB signalling pathway via PKC and MAPK";"Negative feedback regulation of MAPK pathway";"Signal transduction by L1";"FCERI mediated MAPK activation";"Advanced glycosylation endproduct receptor signaling";"Frs2-mediated activation";"RUNX2 regulates osteoblast differentiation";"Oxidative Stress Induced Senescence";"ERK/MAPK targets";"Regulation of the apoptosome activity";"Signal attenuation";"Thrombin signalling through proteinase activated receptors (PARs)";"MAP2K and MAPK activation";"Senescence-Associated Secretory Phenotype (SASP)";"RHO GTPases Activate NADPH Oxidases";"Regulation of HSF1-mediated heat shock response";"Negative regulation of FGFR3 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"mTOR signaling pathway";"ESR-mediated signaling";"Spry regulation of FGF signaling";"Activation of the AP-1 family of transcription factors";"ERKs are inactivated";"Oncogene Induced Senescence";"Regulation of PTEN gene transcription";"Suppression of apoptosis";"Regulation of actin dynamics for phagocytic cup formation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Negative regulation of MAPK pathway";"RAF-independent MAPK1/3 activation";"Golgi Cisternae Pericentriolar Stack Reorganization";"RHO GTPases Activate WASPs and WAVEs";"Negative regulation of FGFR1 signaling";"RSK activation";"Signaling downstream of RAS mutants";"Signaling by high-kinase activity BRAF mutants";"Negative regulation of FGFR2 signaling";"Growth hormone receptor signaling";"Signaling by moderate kinase activity BRAF mutants"
XP_053948733.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_053950430.1	13	MetaCyc: PWY-7822;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-1660662;KEGG: 00603+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7883	"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"CS/DS degradation";"Other glycan degradation";"Anhydromuropeptides recycling II"
XP_053963773.1	10	MetaCyc: PWY-1042;KEGG: 00052+2.7.1.11;MetaCyc: PWY-7385;MetaCyc: PWY-5484;KEGG: 00030+2.7.1.11;KEGG: 00680+2.7.1.11;Reactome: R-HSA-70171;MetaCyc: PWY-1861;KEGG: 00010+2.7.1.11;KEGG: 00051+2.7.1.11	"Glycolysis IV (plant cytosol)";"Galactose metabolism";"1,3-propanediol biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Methane metabolism";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism"
XP_053949323.1	3	Reactome: R-HSA-5696394;Reactome: R-HSA-5689877;Reactome: R-HSA-5696395	"DNA Damage Recognition in GG-NER";"Josephin domain DUBs";"Formation of Incision Complex in GG-NER"
XP_053957789.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-5689896	"Ub-specific processing proteases";"Ovarian tumor domain proteases"
XP_053952720.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_053964976.1	10	Reactome: R-HSA-9022699;Reactome: R-HSA-9022538;Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-9022692;Reactome: R-HSA-3899300;Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017	"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"Regulation of MECP2 expression and activity";"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
XP_053957782.1	6	Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-429958;Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_053955204.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053961343.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053951921.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053948491.1	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
XP_053945921.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053955658.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053970233.1	57	Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-6798695;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-4608870;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-202424	"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"Neutrophil degranulation";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Asymmetric localization of PCP proteins";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Degradation of AXIN";"Degradation of DVL";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Downstream TCR signaling"
XP_053946652.1	3	Reactome: R-HSA-2468052;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813	"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids"
XP_053959845.1	4	Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-112308;Reactome: R-HSA-5576893	"NCAM1 interactions";"Phase 0 - rapid depolarisation";"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase"
XP_053952577.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053963634.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053962451.1	13	KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-7721;MetaCyc: PWY-6859;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-7182;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7709;MetaCyc: PWY-5123	"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Linalool biosynthesis I";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis"
XP_053969743.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053948336.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053954107.1	3	Reactome: R-HSA-5632968;Reactome: R-HSA-5358565;Reactome: R-HSA-5632928	"Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH2"
XP_053966308.1	10	Reactome: R-HSA-210744;Reactome: R-HSA-2894862;Reactome: R-HSA-2197563;Reactome: R-HSA-9013695;Reactome: R-HSA-1912408;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508;Reactome: R-HSA-350054;Reactome: R-HSA-2122947	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 intracellular domain regulates transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053946659.1	2	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_053957844.1	8	Reactome: R-HSA-983712;KEGG: 00190+7.1.2.2;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;KEGG: 00195+7.1.2.2;MetaCyc: PWY-7980;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"Ion channel transport";"Oxidative phosphorylation";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Photosynthesis";"ATP biosynthesis";"Insulin receptor recycling";"Amino acids regulate mTORC1"
XP_053963988.1	7	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053963519.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_053959303.1	4	MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32	"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism"
XP_053948013.1	3	Reactome: R-HSA-1236974;Reactome: R-HSA-1799339;Reactome: R-HSA-9609523	"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_053945742.1	4	Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724	"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"Regulation of PTEN gene transcription"
XP_053956070.1	1	Reactome: R-HSA-204626	"Hypusine synthesis from eIF5A-lysine"
XP_053967006.1	1	Reactome: R-HSA-8953750	"Transcriptional Regulation by E2F6"
XP_053952435.1	3	KEGG: 00860+1.3.3.4;Reactome: R-HSA-189451;MetaCyc: PWY-7159	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"
XP_053952922.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053953791.1	14	MetaCyc: PWY-7411;MetaCyc: PWY-5981;MetaCyc: PWY-6453;MetaCyc: PWY-7589;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7417;MetaCyc: PWY-5667;MetaCyc: PWY-8053;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7587;MetaCyc: PWY-8051;MetaCyc: PWY-8055	"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Stigma estolide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Synthesis of PA";"Plasmalogen biosynthesis";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis II";"Glycerolipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis"
XP_053957095.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053950976.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_053956162.1	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
XP_053945896.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_053951749.1	6	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-6798695	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Ion channel transport";"Neutrophil degranulation"
XP_053947398.1	4	MetaCyc: PWY-7119;MetaCyc: PWY-6483;KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662	"Ceramide and sphingolipid recycling and degradation (yeast)";"Ceramide degradation (generic)";"Sphingolipid metabolism";"Glycosphingolipid metabolism"
XP_053960048.1	8	MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5789;MetaCyc: PWY-241;MetaCyc: PWY-5744;MetaCyc: PWY-7117	"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type"
XP_053957631.1	5	MetaCyc: PWY-3781;MetaCyc: PWY-6692;MetaCyc: PWY-7082;KEGG: 00190+7.1.1.8;MetaCyc: PWY-7279	"Aerobic respiration I (cytochrome c)";"Fe(II) oxidation";"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Oxidative phosphorylation";"Aerobic respiration II (cytochrome c) (yeast)"
XP_053957559.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053959706.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_053953379.1	14	Reactome: R-HSA-975634;MetaCyc: PWY-8053;MetaCyc: PWY-7417;Reactome: R-HSA-1482788;MetaCyc: PWY-7783;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00592+3.1.1.4	"Retinoid metabolism and transport";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PC";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism"
XP_053952074.1	7	KEGG: 00564+2.7.8.11;KEGG: 00562+2.7.8.11;KEGG: 04070+2.7.8.11;MetaCyc: PWY-7625;MetaCyc: PWY-6351;MetaCyc: PWY-6352;Reactome: R-HSA-1483226	"Glycerophospholipid metabolism";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Phosphatidylinositol biosynthesis II (eukaryotes)";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"3-phosphoinositide biosynthesis";"Synthesis of PI"
XP_053958234.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053951306.1	4	Reactome: R-HSA-2161541;KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221;Reactome: R-HSA-499943	"Abacavir metabolism";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates"
XP_053963288.1	1	Reactome: R-HSA-5617833	"Cilium Assembly"
XP_053952744.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053952229.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions"
XP_053951881.1	8	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Activation of RAC1";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053952222.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053946534.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_053959536.1	5	Reactome: R-HSA-5625740;Reactome: R-HSA-75035;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-111447	"RHO GTPases activate PKNs";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria"
XP_053947800.1	56	Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-4608870;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-187577;Reactome: R-HSA-211733	"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of AXIN";"Degradation of DVL";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Asymmetric localization of PCP proteins";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation"
XP_053963631.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053962454.1	13	KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-7721;MetaCyc: PWY-6859;MetaCyc: PWY-6383;MetaCyc: PWY-5122;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7182;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-7709;MetaCyc: PWY-5123	"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Linalool biosynthesis I";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis"
XP_053965985.1	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
XP_053960040.1	8	MetaCyc: PWY-5789;KEGG: 00910+4.2.1.1;MetaCyc: PWY-6142;MetaCyc: PWY-5743;MetaCyc: PWY-7115;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-241	"3-hydroxypropanoate/4-hydroxybutanate cycle";"Nitrogen metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NADP-ME type"
XP_053946717.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053950276.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053952385.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053958523.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053958827.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053959091.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053957512.1	14	MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8053;MetaCyc: PWY-5667;MetaCyc: PWY-7417;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-7411	"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Phosphatidate biosynthesis (yeast)"
XP_053963844.1	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
XP_053946923.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053950135.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053945837.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053945079.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053957988.1	25	Reactome: R-HSA-437239;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-5626467;Reactome: R-HSA-6811434;Reactome: R-HSA-9619483;Reactome: R-HSA-2132295;Reactome: R-HSA-1445148;Reactome: R-HSA-8955332;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-5663220;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-380270;Reactome: R-HSA-6807878;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-3371497;Reactome: R-HSA-68877;Reactome: R-HSA-190861;Reactome: R-HSA-2467813	"Recycling pathway of L1";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"RHO GTPases activate IQGAPs";"COPI-dependent Golgi-to-ER retrograde traffic";"Activation of AMPK downstream of NMDARs";"MHC class II antigen presentation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Carboxyterminal post-translational modifications of tubulin";"Aggrephagy";"Cilium Assembly";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Recruitment of mitotic centrosome proteins and complexes";"COPI-mediated anterograde transport";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Mitotic Prometaphase";"Gap junction assembly";"Separation of Sister Chromatids"
XP_053947390.1	3	KEGG: 00330+1.14.11.2;MetaCyc: PWY-7894;Reactome: R-HSA-1650814	"Arginine and proline metabolism";"Procollagen hydroxylation and glycosylation";"Collagen biosynthesis and modifying enzymes"
XP_053951837.1	1	Reactome: R-HSA-5250924	"B-WICH complex positively regulates rRNA expression"
XP_053951533.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053958768.1	5	MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109	"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis"
XP_053945160.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053963095.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053953716.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_053947648.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053962334.1	8	Reactome: R-HSA-164378;Reactome: R-HSA-180024;Reactome: R-HSA-5610787;Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-983231;Reactome: R-HSA-381676	"PKA activation in glucagon signalling";"DARPP-32 events";"Hedgehog 'off' state";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"Factors involved in megakaryocyte development and platelet production";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"
XP_053948533.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053948072.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053946148.1	5	Reactome: R-HSA-8936459;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-3214841;Reactome: R-HSA-3769402	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines";"Deactivation of the beta-catenin transactivating complex"
XP_053945811.1	1	Reactome: R-HSA-163765	"ChREBP activates metabolic gene expression"
XP_053954570.1	3	Reactome: R-HSA-1650814;MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2	"Collagen biosynthesis and modifying enzymes";"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism"
XP_053957657.1	14	MetaCyc: PWY-7411;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.15;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;Reactome: R-HSA-75896;MetaCyc: PWY-5667;MetaCyc: PWY-8053;KEGG: 00564+2.3.1.42;KEGG: 00561+2.3.1.15;MetaCyc: PWY-7587;MetaCyc: PWY-8055;Reactome: R-HSA-9033241;MetaCyc: PWY-8051	"Phosphatidate biosynthesis (yeast)";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Plasmalogen biosynthesis";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis II";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Palmitoyl ethanolamide biosynthesis";"Peroxisomal protein import";"Anandamide biosynthesis I"
XP_053961482.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
XP_053950199.1	10	Reactome: R-HSA-8939243;Reactome: R-HSA-8934903;Reactome: R-HSA-445144;Reactome: R-HSA-6814122;Reactome: R-HSA-2514853;Reactome: R-HSA-201688;Reactome: R-HSA-6804756;Reactome: R-HSA-1483191;Reactome: R-HSA-8948751;Reactome: R-HSA-6798695	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Receptor Mediated Mitophagy";"Signal transduction by L1";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Condensation of Prometaphase Chromosomes";"WNT mediated activation of DVL";"Regulation of TP53 Activity through Phosphorylation";"Synthesis of PC";"Regulation of PTEN stability and activity";"Neutrophil degranulation"
XP_053946762.1	7	Reactome: R-HSA-606279;Reactome: R-HSA-5689603;Reactome: R-HSA-5689880;Reactome: R-HSA-201722;Reactome: R-HSA-5696394;Reactome: R-HSA-3214847;Reactome: R-HSA-171319	"Deposition of new CENPA-containing nucleosomes at the centromere";"UCH proteinases";"Ub-specific processing proteases";"Formation of the beta-catenin:TCF transactivating complex";"DNA Damage Recognition in GG-NER";"HATs acetylate histones";"Telomere Extension By Telomerase"
XP_053959699.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053946787.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053969129.1	6	Reactome: R-HSA-4086398;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-4411364;Reactome: R-HSA-8951430	"Ca2+ pathway";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"RUNX3 regulates WNT signaling"
XP_053951811.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053955768.1	3	Reactome: R-HSA-381426;Reactome: R-HSA-5362798;Reactome: R-HSA-8957275	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Release of Hh-Np from the secreting cell";"Post-translational protein phosphorylation"
XP_053961546.1	6	Reactome: R-HSA-201722;Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-3769402;Reactome: R-HSA-5626467;Reactome: R-HSA-2173796	"Formation of the beta-catenin:TCF transactivating complex";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Deactivation of the beta-catenin transactivating complex";"RHO GTPases activate IQGAPs";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"
XP_053957210.1	26	Reactome: R-HSA-5626467;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-1445148;Reactome: R-HSA-8955332;Reactome: R-HSA-380320;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-437239;Reactome: R-HSA-190840;Reactome: R-HSA-389960;Reactome: R-HSA-9609736;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-3371497;Reactome: R-HSA-190861;Reactome: R-HSA-2467813;Reactome: R-HSA-389977;Reactome: R-HSA-5663220;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878	"RHO GTPases activate IQGAPs";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Carboxyterminal post-translational modifications of tubulin";"Recruitment of NuMA to mitotic centrosomes";"Aggrephagy";"Cilium Assembly";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Recycling pathway of L1";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Assembly and cell surface presentation of NMDA receptors";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Gap junction assembly";"Separation of Sister Chromatids";"Post-chaperonin tubulin folding pathway";"RHO GTPases Activate Formins";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport"
XP_053965255.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053952541.1	2	Reactome: R-HSA-5619061;Reactome: R-HSA-425397	"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)";"Transport of vitamins, nucleosides, and related molecules"
XP_053969543.1	7	Reactome: R-HSA-110362;Reactome: R-HSA-5696400;Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-5685939;Reactome: R-HSA-3108214;Reactome: R-HSA-2173795	"POLB-Dependent Long Patch Base Excision Repair";"Dual Incision in GG-NER";"DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"HDR through MMEJ (alt-NHEJ)";"SUMOylation of DNA damage response and repair proteins";"Downregulation of SMAD2/3:SMAD4 transcriptional activity"
XP_053963617.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053951053.1	3	MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167	"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol"
XP_053957589.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053954868.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053947247.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053967765.1	4	Reactome: R-HSA-186763;Reactome: R-HSA-8875555;Reactome: R-HSA-912631;Reactome: R-HSA-8875656	"Downstream signal transduction";"MET activates RAP1 and RAC1";"Regulation of signaling by CBL";"MET receptor recycling"
XP_053961645.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_053945851.1	33	Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-3301854;Reactome: R-HSA-5663220;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-168333;Reactome: R-HSA-141444;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-9648025;Reactome: R-HSA-159230;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-4615885	"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"Nuclear Pore Complex (NPC) Disassembly";"RHO GTPases Activate Formins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"EML4 and NUDC in mitotic spindle formation";"Transport of the SLBP Dependant Mature mRNA";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Separation of Sister Chromatids";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins"
XP_053957617.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053952355.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053969732.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053948306.1	4	Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163	"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway"
XP_053954137.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_053953756.1	3	MetaCyc: PWY-3961;Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33	"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_053969739.1	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
XP_053967313.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053952366.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053963582.1	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
XP_053965215.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053963258.1	6	MetaCyc: PWY-7900;MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085;MetaCyc: PWY-622;KEGG: 00500+2.4.1.18	"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate";"Starch biosynthesis";"Starch and sucrose metabolism"
XP_053963589.1	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
XP_053963918.1	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
XP_053961339.1	7	Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-6783310	"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Fanconi Anemia Pathway"
XP_053954860.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053954578.1	24	Reactome: R-HSA-389357;KEGG: 05163+2.7.11.1;Reactome: R-HSA-202424;Reactome: R-HSA-114604;Reactome: R-HSA-2871837;Reactome: R-HSA-1257604;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5674400;Reactome: R-HSA-354192;Reactome: R-HSA-165158;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5625740;KEGG: 05165+2.7.11.1;Reactome: R-HSA-9634635;Reactome: R-HSA-5218921;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-2730905;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-392451;Reactome: R-HSA-5607764;Reactome: R-HSA-444257;KEGG: 04151+2.7.11.1	"CD28 dependent PI3K/Akt signaling";"Human cytomegalovirus infection";"Downstream TCR signaling";"GPVI-mediated activation cascade";"FCERI mediated NF-kB activation";"PIP3 activates AKT signaling";"Relaxin signaling pathway";"Constitutive Signaling by AKT1 E17K in Cancer";"Integrin signaling";"Activation of AKT2";"mTOR signaling pathway";"RHO GTPases activate PKNs";"Human papillomavirus infection";"Estrogen-stimulated signaling through PRKCZ";"VEGFR2 mediated cell proliferation";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"Role of LAT2/NTAL/LAB on calcium mobilization";"Thermogenesis";"Human immunodeficiency virus 1 infection";"G beta:gamma signalling through PI3Kgamma";"CLEC7A (Dectin-1) signaling";"RSK activation";"PI3K-Akt signaling pathway"
XP_053948742.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053957573.1	2	Reactome: R-HSA-6804758;Reactome: R-HSA-3214847	"Regulation of TP53 Activity through Acetylation";"HATs acetylate histones"
XP_053946140.1	4	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Ion channel transport"
XP_053961361.1	24	Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-163560;Reactome: R-HSA-4420097;Reactome: R-HSA-381676;Reactome: R-HSA-5610783;Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-5687128;Reactome: R-HSA-8853659;Reactome: R-HSA-5610780;Reactome: R-HSA-422356;Reactome: R-HSA-180024;Reactome: R-HSA-9634600;Reactome: R-HSA-5610785;Reactome: R-HSA-5621575;Reactome: R-HSA-9010642;Reactome: R-HSA-8963896;KEGG: 04150+2.7.11.11;Reactome: R-HSA-392517;Reactome: R-HSA-111931;Reactome: R-HSA-163615;Reactome: R-HSA-983231;Reactome: R-HSA-163358	"PKA activation in glucagon signalling";"Hedgehog 'off' state";"Triglyceride catabolism";"VEGFA-VEGFR2 Pathway";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Degradation of GLI2 by the proteasome";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"MAPK6/MAPK4 signaling";"RET signaling";"Degradation of GLI1 by the proteasome";"Regulation of insulin secretion";"DARPP-32 events";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"GLI3 is processed to GLI3R by the proteasome";"CD209 (DC-SIGN) signaling";"ROBO receptors bind AKAP5";"HDL assembly";"mTOR signaling pathway";"Rap1 signalling";"PKA-mediated phosphorylation of CREB";"PKA activation";"Factors involved in megakaryocyte development and platelet production";"PKA-mediated phosphorylation of key metabolic factors"
XP_053950400.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053953353.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_053948749.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053952763.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053946121.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_053951013.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-162658;Reactome: R-HSA-204005	"COPI-mediated anterograde transport";"Golgi Cisternae Pericentriolar Stack Reorganization";"COPII-mediated vesicle transport"
XP_053948168.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053948320.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053966768.1	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_053969369.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053962681.1	16	Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706	"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_053969387.1	3	KEGG: 00240+1.3.5.2;Reactome: R-HSA-500753;MetaCyc: PWY-5686	"Pyrimidine metabolism";"Pyrimidine biosynthesis";"UMP biosynthesis I"
XP_053949128.1	9	Reactome: R-HSA-416482;Reactome: R-HSA-2029482;Reactome: R-HSA-2871796;Reactome: R-HSA-114604;Reactome: R-HSA-194840;Reactome: R-HSA-5218920;Reactome: R-HSA-193648;Reactome: R-HSA-2871809;Reactome: R-HSA-4420097	"G alpha (12/13) signalling events";"Regulation of actin dynamics for phagocytic cup formation";"FCERI mediated MAPK activation";"GPVI-mediated activation cascade";"Rho GTPase cycle";"VEGFR2 mediated vascular permeability";"NRAGE signals death through JNK";"FCERI mediated Ca+2 mobilization";"VEGFA-VEGFR2 Pathway"
XP_053950951.1	1	MetaCyc: PWY-7379	"Mrna capping II"
XP_053954429.1	8	MetaCyc: PWY-7179;MetaCyc: PWY-7179-1;Reactome: R-HSA-5683826;KEGG: 00230+3.5.4.4;MetaCyc: PWY-6611;MetaCyc: PWY-6609;Reactome: R-HSA-74217;Reactome: R-HSA-6798695	"Purine deoxyribonucleosides degradation I";"Purine deoxyribonucleosides degradation II";"Surfactant metabolism";"Purine metabolism";"Adenine and adenosine salvage V";"Adenine and adenosine salvage III";"Purine salvage";"Neutrophil degranulation"
XP_053961493.1	57	Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-450408;Reactome: R-HSA-6798695;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-4608870;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-5632684;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-174184;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541	"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neutrophil degranulation";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Asymmetric localization of PCP proteins";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of DVL";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Hedgehog 'on' state";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway"
XP_053948341.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053958450.1	1	Reactome: R-HSA-8849175	"Threonine catabolism"
XP_053957307.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_053968740.1	1	Reactome: R-HSA-74217	"Purine salvage"
XP_053961762.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053962019.1	4	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-1912420	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi"
XP_053963401.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053954598.1	11	KEGG: 00480+1.1.1.42;MetaCyc: PWY-6549;KEGG: 00020+1.1.1.42;MetaCyc: PWY-6969;KEGG: 00720+1.1.1.42;MetaCyc: PWY-7254;MetaCyc: PWY-7124;MetaCyc: PWY-5913;MetaCyc: PWY-6728;MetaCyc: PWY-7268;Reactome: R-HSA-71403	"Glutathione metabolism";"L-glutamine biosynthesis III";"Citrate cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"TCA cycle VII (acetate-producers)";"Ethylene biosynthesis V (engineered)";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Citric acid cycle (TCA cycle)"
XP_053961731.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053957897.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053958418.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053949508.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053962637.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053952333.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053964954.1	6	Reactome: R-HSA-1989781;Reactome: R-HSA-9022537;Reactome: R-HSA-9029569;Reactome: R-HSA-9609690;Reactome: R-HSA-9022692;Reactome: R-HSA-3214815	"PPARA activates gene expression";"Loss of MECP2 binding ability to the NCoR/SMRT complex";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"HCMV Early Events";"Regulation of MECP2 expression and activity";"HDACs deacetylate histones"
XP_053954590.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_053962764.1	27	Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-4570464;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377	"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"SUMOylation of RNA binding proteins";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of SUMOylation proteins"
XP_053962059.1	7	KEGG: 00230+2.4.2.14;MetaCyc: PWY-6277;Reactome: R-HSA-73817;KEGG: 00250+2.4.2.14;MetaCyc: PWY-7282;MetaCyc: PWY-6122;MetaCyc: PWY-6121	"Purine metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Alanine, aspartate and glutamate metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"5-aminoimidazole ribonucleotide biosynthesis I"
XP_053945035.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053950172.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_053967574.1	5	Reactome: R-HSA-75896;Reactome: R-HSA-9033500;KEGG: 00565+2.5.1.26;MetaCyc: PWY-7782;Reactome: R-HSA-9033241	"Plasmalogen biosynthesis";"TYSND1 cleaves peroxisomal proteins";"Ether lipid metabolism";"Plasmalogen biosynthesis";"Peroxisomal protein import"
XP_053946361.1	16	Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-9010553;Reactome: R-HSA-8951664;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-75955;Reactome: R-HSA-983168;Reactome: R-HSA-167287;Reactome: R-HSA-180585;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-1234176;Reactome: R-HSA-167246;Reactome: R-HSA-167238;Reactome: R-HSA-112382	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Regulation of expression of SLITs and ROBOs";"Neddylation";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Antigen processing: Ubiquitination & Proteasome degradation";"HIV elongation arrest and recovery";"Vif-mediated degradation of APOBEC3G";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex"
XP_053962230.1	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
XP_053948328.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_053966760.1	6	Reactome: R-HSA-418592;Reactome: R-HSA-434316;Reactome: R-HSA-416476;Reactome: R-HSA-399997;Reactome: R-HSA-456926;Reactome: R-HSA-428930	"ADP signalling through P2Y purinoceptor 1";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G alpha (q) signalling events";"Acetylcholine regulates insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor"
XP_053957314.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053957401.1	13	Reactome: R-HSA-2132295;Reactome: R-HSA-182218;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-5099900;Reactome: R-HSA-5140745;Reactome: R-HSA-8866427;Reactome: R-HSA-8964038;Reactome: R-HSA-167590;Reactome: R-HSA-437239;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-177504	"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD4";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"VLDLR internalisation and degradation";"LDL clearance";"Nef Mediated CD4 Down-regulation";"Recycling pathway of L1";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Retrograde neurotrophin signalling"
XP_053945474.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_053951555.1	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
XP_053956322.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053967399.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_053945566.1	3	Reactome: R-HSA-6787639;Reactome: R-HSA-727802;Reactome: R-HSA-5619078	"GDP-fucose biosynthesis";"Transport of nucleotide sugars";"Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)"
XP_053950824.1	8	Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-6804757;Reactome: R-HSA-8866652;Reactome: R-HSA-6781823;Reactome: R-HSA-8948747;Reactome: R-HSA-6782210;Reactome: R-HSA-5689880	"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Regulation of TP53 Degradation";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Formation of TC-NER Pre-Incision Complex";"Regulation of PTEN localization";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Ub-specific processing proteases"
XP_053955025.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053969894.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053961757.1	6	KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632;MetaCyc: PWY-7433;KEGG: 00512+2.4.1.122;Reactome: R-HSA-913709;MetaCyc: PWY-7290	"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Mucin core 1 and core 2 O-glycosylation";"Mucin type O-glycan biosynthesis";"O-linked glycosylation of mucins";"Escherichia coli serotype O86 O-antigen biosynthesis"
XP_053946452.1	6	Reactome: R-HSA-9010553;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-975957;Reactome: R-HSA-72187	"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA 3'-end processing"
XP_053950153.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_053946805.1	4	Reactome: R-HSA-446210;MetaCyc: PWY-6517;KEGG: 00520+2.7.1.59;MetaCyc: PWY-6906	"Synthesis of UDP-N-acetyl-glucosamine";"N-acetylglucosamine degradation II";"Amino sugar and nucleotide sugar metabolism";"Chitin derivatives degradation"
XP_053962532.1	2	Reactome: R-HSA-1799339;Reactome: R-HSA-446203	"SRP-dependent cotranslational protein targeting to membrane";"Asparagine N-linked glycosylation"
XP_053962073.1	5	MetaCyc: PWY-7863;KEGG: 00740+2.7.1.26;Reactome: R-HSA-196843;MetaCyc: PWY-6168;MetaCyc: PWY-5523	"Roseoflavin biosynthesis";"Riboflavin metabolism";"Vitamin B2 (riboflavin) metabolism";"Flavin biosynthesis III (fungi)";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)"
XP_053953415.1	7	MetaCyc: PWY-6363;KEGG: 00562+3.1.3.25;KEGG: 04070+3.1.3.25;KEGG: 00521+3.1.3.25;MetaCyc: PWY-2301;Reactome: R-HSA-1855183;MetaCyc: PWY-4702	"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Streptomycin biosynthesis";"Myo-inositol biosynthesis";"Synthesis of IP2, IP, and Ins in the cytosol";"Phytate degradation I"
XP_053948474.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053947294.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053951656.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053950937.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053959867.1	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Major pathway of rRNA processing in the nucleolus and cytosol";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053945665.1	4	KEGG: 05235+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"DARPP-32 events";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053967802.1	3	Reactome: R-HSA-6783984;KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"Glycine degradation";"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_053947370.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053969304.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_053967547.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053967771.1	4	Reactome: R-HSA-186763;Reactome: R-HSA-912631;Reactome: R-HSA-8875656;Reactome: R-HSA-8875555	"Downstream signal transduction";"Regulation of signaling by CBL";"MET receptor recycling";"MET activates RAP1 and RAC1"
XP_053967843.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex"
XP_053965131.1	8	Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68689;Reactome: R-HSA-68616;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68867	"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"CDC6 association with the ORC:origin complex";"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the pre-replicative complex"
XP_053959130.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053953028.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053962067.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053969317.1	1	Reactome: R-HSA-390696	"Adrenoceptors"
XP_053953809.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053959138.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_053969926.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053968104.1	6	Reactome: R-HSA-5684045;Reactome: R-HSA-9603798;Reactome: R-HSA-2046105;Reactome: R-HSA-390247;Reactome: R-HSA-2046106;Reactome: R-HSA-1369062	"Defective ABCD1 causes adrenoleukodystrophy (ALD)";"Class I peroxisomal membrane protein import";"Linoleic acid (LA) metabolism";"Beta-oxidation of very long chain fatty acids";"alpha-linolenic acid (ALA) metabolism";"ABC transporters in lipid homeostasis"
XP_053945515.1	1	Reactome: R-HSA-480985	"Synthesis of dolichyl-phosphate-glucose"
XP_053950996.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_053945876.1	5	MetaCyc: PWY-3341;KEGG: 00330+1.5.1.2;Reactome: R-HSA-8964539;MetaCyc: PWY-6344;MetaCyc: PWY-4981	"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism";"Glutamate and glutamine metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)"
XP_053953547.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053947378.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
XP_053961375.1	8	Reactome: R-HSA-9636467;Reactome: R-HSA-182218;Reactome: R-HSA-167590;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Blockage of phagosome acidification";"Nef Mediated CD8 Down-regulation";"Nef Mediated CD4 Down-regulation";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
XP_053961923.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053950237.1	26	Reactome: R-HSA-3899300;Reactome: R-HSA-3134973;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-9013508;Reactome: R-HSA-1234158;Reactome: R-HSA-5621575;Reactome: R-HSA-210744;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-9018519;Reactome: R-HSA-9614657;Reactome: R-HSA-1989781;Reactome: R-HSA-918233;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-8866907;Reactome: R-HSA-933541;Reactome: R-HSA-9617629;Reactome: R-HSA-2122947;Reactome: R-HSA-3371568;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-381340;Reactome: R-HSA-2894862;Reactome: R-HSA-9013695	"SUMOylation of transcription cofactors";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Circadian Clock";"RORA activates gene expression";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of gene expression by Hypoxia-inducible Factor";"CD209 (DC-SIGN) signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"Estrogen-dependent gene expression";"FOXO-mediated transcription of cell death genes";"PPARA activates gene expression";"TRAF3-dependent IRF activation pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"Activation of the TFAP2 (AP-2) family of transcription factors";"TRAF6 mediated IRF7 activation";"Regulation of FOXO transcriptional activity by acetylation";"NOTCH1 Intracellular Domain Regulates Transcription";"Attenuation phase";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription"
XP_053948585.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053953392.1	6	Reactome: R-HSA-72165;Reactome: R-HSA-191859;Reactome: R-HSA-72163;Reactome: R-HSA-77588;Reactome: R-HSA-111367;Reactome: R-HSA-73856	"mRNA Splicing - Minor Pathway";"snRNP Assembly";"mRNA Splicing - Major Pathway";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"SLBP independent Processing of Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination"
XP_053952094.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053949943.1	1	Reactome: R-HSA-2995383	"Initiation of Nuclear Envelope Reformation"
XP_053945616.1	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
XP_053954992.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053957434.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_053959873.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
XP_053965078.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053952453.1	5	Reactome: R-HSA-211976;Reactome: R-HSA-1362409;Reactome: R-HSA-196108;Reactome: R-HSA-5579026;Reactome: R-HSA-2395516	"Endogenous sterols";"Mitochondrial iron-sulfur cluster biogenesis";"Pregnenolone biosynthesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Electron transport from NADPH to Ferredoxin"
XP_053959577.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053962743.1	10	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5689880;Reactome: R-HSA-3214847;Reactome: R-HSA-201722	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Ub-specific processing proteases";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex"
XP_053962871.1	6	KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7039;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_053952342.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053967150.1	1	Reactome: R-HSA-5368286	"Mitochondrial translation initiation"
XP_053952349.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053960992.1	5	Reactome: R-HSA-6798695;KEGG: 00760+6.3.4.21;MetaCyc: PWY-5381;Reactome: R-HSA-1368108;Reactome: R-HSA-197264	"Neutrophil degranulation";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinamide salvaging"
XP_053953044.1	3	Reactome: R-HSA-8939243;Reactome: R-HSA-2559580;Reactome: R-HSA-8943724	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Oxidative Stress Induced Senescence";"Regulation of PTEN gene transcription"
XP_053959435.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_053961879.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053966957.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053963462.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053952086.1	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
XP_053962900.1	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
XP_053964237.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053963469.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053953305.1	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
XP_053949995.1	5	Reactome: R-HSA-5674400;Reactome: R-HSA-389357;Reactome: R-HSA-1257604;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757	"Constitutive Signaling by AKT1 E17K in Cancer";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation"
XP_053964113.1	3	Reactome: R-HSA-8856828;Reactome: R-HSA-8854214;Reactome: R-HSA-8875656	"Clathrin-mediated endocytosis";"TBC/RABGAPs";"MET receptor recycling"
XP_053962654.1	19	MetaCyc: PWY-7384;Reactome: R-HSA-6798695;MetaCyc: PWY-5913;MetaCyc: PWY-6728;Reactome: R-HSA-71403;Reactome: R-HSA-163765;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;KEGG: 00020+2.3.3.8;KEGG: 00660+6.2.1.5;KEGG: 00720+6.2.1.5;Reactome: R-HSA-75105;MetaCyc: PWY-5392;MetaCyc: PWY-6969;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5537;MetaCyc: PWY-5172;MetaCyc: PWY-5690	"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Neutrophil degranulation";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"ChREBP activates metabolic gene expression";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"C5-Branched dibasic acid metabolism";"Carbon fixation pathways in prokaryotes";"Fatty acyl-CoA biosynthesis";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"Acetyl-coa biosynthesis III (from citrate)";"TCA cycle II (plants and fungi)"
XP_053963431.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053958185.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_053952893.1	16	Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-1799339	"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane"
XP_053969891.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053963396.1	4	KEGG: 00330+2.5.1.16;KEGG: 00480+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00270+2.5.1.16	"Arginine and proline metabolism";"Glutathione metabolism";"Metabolism of polyamines";"Cysteine and methionine metabolism"
XP_053961619.1	5	MetaCyc: PWY-6855;MetaCyc: PWY-7822;Reactome: R-HSA-189085;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902	"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Digestion of dietary carbohydrate";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)"
XP_053950821.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053961569.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053957431.1	13	Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053966610.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_053948377.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_053951344.1	2	Reactome: R-HSA-2022377;Reactome: R-HSA-6798695	"Metabolism of Angiotensinogen to Angiotensins";"Neutrophil degranulation"
XP_053946899.1	6	KEGG: 00510+2.4.1.143;MetaCyc: PWY-7426;MetaCyc: PWY-7920;KEGG: 00513+2.4.1.143;Reactome: R-HSA-975578;Reactome: R-HSA-4793952	"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Various types of N-glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)"
XP_053952091.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053966326.1	4	Reactome: R-HSA-112043;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-6814122	"PLC beta mediated events";"G alpha (i) signalling events";"G-protein activation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_053955166.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053946309.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_053961096.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053964981.1	10	Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-9022692;Reactome: R-HSA-3899300;Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-9022699;Reactome: R-HSA-9022538	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of MECP2 expression and activity";"SUMOylation of transcription cofactors";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA"
XP_053953774.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_053967158.1	10	MetaCyc: PWY-7391;MetaCyc: PWY-7524;KEGG: 00900+2.3.3.10;MetaCyc: PWY-6174;Reactome: R-HSA-1989781;KEGG: 00072+2.3.3.10;KEGG: 00650+2.3.3.10;KEGG: 00280+2.3.3.10;MetaCyc: PWY-7571;MetaCyc: PWY-922	"Isoprene biosynthesis II (engineered)";"Mevalonate pathway III (archaea)";"Terpenoid backbone biosynthesis";"Mevalonate pathway II (archaea)";"PPARA activates gene expression";"Synthesis and degradation of ketone bodies";"Butanoate metabolism";"Valine, leucine and isoleucine degradation";"Ferrichrome A biosynthesis";"Mevalonate pathway I"
XP_053949530.1	3	Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2206291	"HS-GAG degradation";"Neutrophil degranulation";"MPS IIIC - Sanfilippo syndrome C"
XP_053957806.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053957793.1	1	Reactome: R-HSA-5624958	"ARL13B-mediated ciliary trafficking of INPP5E"
XP_053961531.1	5	KEGG: 00220+1.14.13.39;Reactome: R-HSA-1222556;KEGG: 00330+1.14.13.39;MetaCyc: PWY-4983;Reactome: R-HSA-392154	"Arginine biosynthesis";"ROS and RNS production in phagocytes";"Arginine and proline metabolism";"Nitric oxide biosynthesis II (mammals)";"Nitric oxide stimulates guanylate cyclase"
XP_053956825.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053958308.1	6	MetaCyc: PWY-7433;KEGG: 00512+2.4.1.122;KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632;MetaCyc: PWY-7290;Reactome: R-HSA-913709	"Mucin core 1 and core 2 O-glycosylation";"Mucin type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Escherichia coli serotype O86 O-antigen biosynthesis";"O-linked glycosylation of mucins"
XP_053969676.1	8	KEGG: 04926+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Activation of RAC1";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053949018.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053945715.1	14	MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-7619;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5972;MetaCyc: PWY-7035	"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis"
XP_053959100.1	10	Reactome: R-HSA-432720;Reactome: R-HSA-917729;Reactome: R-HSA-9635644;Reactome: R-HSA-5689880;Reactome: R-HSA-182971;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6807004;Reactome: R-HSA-9636383;Reactome: R-HSA-8875360	"Lysosome Vesicle Biogenesis";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Inhibition of membrane repair";"Ub-specific processing proteases";"EGFR downregulation";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Negative regulation of MET activity";"Prevention of phagosomal-lysosomal fusion";"InlB-mediated entry of Listeria monocytogenes into host cell"
XP_053967077.1	3	Reactome: R-HSA-5696394;Reactome: R-HSA-3108214;Reactome: R-HSA-5696395	"DNA Damage Recognition in GG-NER";"SUMOylation of DNA damage response and repair proteins";"Formation of Incision Complex in GG-NER"
XP_053950600.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053953747.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053961734.1	8	Reactome: R-HSA-6798695;KEGG: 00240+3.5.4.5;Reactome: R-HSA-73614;MetaCyc: PWY-6556;MetaCyc: PWY-7181;MetaCyc: PWY-7193;KEGG: 00983+3.5.4.5;MetaCyc: PWY-7199	"Neutrophil degranulation";"Pyrimidine metabolism";"Pyrimidine salvage";"Pyrimidine ribonucleosides salvage II";"Pyrimidine deoxyribonucleosides degradation";"Pyrimidine ribonucleosides salvage I";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleosides salvage"
XP_053967180.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_053952699.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053953188.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053962502.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053947965.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053948344.1	1	MetaCyc: PWY-6938	"NADH repair"
XP_053962847.1	2	Reactome: R-HSA-3214847;Reactome: R-HSA-6804758	"HATs acetylate histones";"Regulation of TP53 Activity through Acetylation"
XP_053965540.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053969816.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-5627123	"Clathrin-mediated endocytosis";"RHO GTPases activate PAKs"
XP_053959777.1	2	Reactome: R-HSA-416993;Reactome: R-HSA-202733	"Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall"
XP_053963404.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053962509.1	5	Reactome: R-HSA-1989781;Reactome: R-HSA-211981;Reactome: R-HSA-211976;Reactome: R-HSA-211945;Reactome: R-HSA-8937144	"PPARA activates gene expression";"Xenobiotics";"Endogenous sterols";"Phase I - Functionalization of compounds";"Aryl hydrocarbon receptor signalling"
XP_053961260.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053948785.1	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_053966931.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053960235.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_053968249.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_053961051.1	58	Reactome: R-HSA-6798695;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-450408;Reactome: R-HSA-4608870;Reactome: R-HSA-174178;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-5658442;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-69481;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-5689901;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-9604323;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050	"Neutrophil degranulation";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Asymmetric localization of PCP proteins";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Regulation of RAS by GAPs";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"G2/M Checkpoints";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Metalloprotease DUBs";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Negative regulation of NOTCH4 signaling";"Neddylation";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"
XP_053964060.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053945471.1	7	Reactome: R-HSA-389957;Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-5620922;Reactome: R-HSA-8950505;Reactome: R-HSA-390471;Reactome: R-HSA-389960	"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC"
XP_053957311.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053959047.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_053962732.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1482798	"Mitochondrial protein import";"Acyl chain remodeling of CL"
XP_053965548.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053961124.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053957646.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_053952016.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_053949058.1	10	KEGG: 00230+3.5.2.17;Reactome: R-HSA-2453864;Reactome: R-HSA-6798695;Reactome: R-HSA-977225;Reactome: R-HSA-975634;Reactome: R-HSA-3000171;MetaCyc: PWY-7849;MetaCyc: PWY-7394;MetaCyc: PWY-5691;Reactome: R-HSA-2453902	"Purine metabolism";"Retinoid cycle disease events";"Neutrophil degranulation";"Amyloid fiber formation";"Retinoid metabolism and transport";"Non-integrin membrane-ECM interactions";"Urate conversion to allantoin III";"Urate conversion to allantoin II";"Urate conversion to allantoin I";"The canonical retinoid cycle in rods (twilight vision)"
XP_053964068.1	2	KEGG: 00514+2.4.1.221;Reactome: R-HSA-1912399	"Other types of O-glycan biosynthesis";"Pre-NOTCH Processing in the Endoplasmic Reticulum"
XP_053951755.1	18	Reactome: R-HSA-1483166;Reactome: R-HSA-1482839;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482801;MetaCyc: PWY-8053;MetaCyc: PWY-7417;Reactome: R-HSA-1482925;Reactome: R-HSA-1482788;MetaCyc: PWY-7783;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-6803;Reactome: R-HSA-1482922;KEGG: 00592+3.1.1.4	"Synthesis of PA";"Acyl chain remodelling of PE";"Glycerophospholipid metabolism";"Acyl chain remodelling of PS";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PG";"Acyl chain remodelling of PC";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"Ether lipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PI";"alpha-Linolenic acid metabolism"
XP_053945694.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053949932.1	3	Reactome: R-HSA-73621;Reactome: R-HSA-196807;Reactome: R-HSA-74259	"Pyrimidine catabolism";"Nicotinate metabolism";"Purine catabolism"
XP_053961557.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_053951471.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_053969856.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053950608.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_053947265.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-8876725	"Respiratory electron transport";"Protein methylation"
XP_053949010.1	3	Reactome: R-HSA-72165;Reactome: R-HSA-72163;Reactome: R-HSA-5250924	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway";"B-WICH complex positively regulates rRNA expression"
XP_053958300.1	27	Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-3301854;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-168271	"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Nuclear Pore Complex (NPC) Disassembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Transport of Ribonucleoproteins into the Host Nucleus"
XP_053967571.1	5	Reactome: R-HSA-75896;Reactome: R-HSA-9033500;KEGG: 00565+2.5.1.26;MetaCyc: PWY-7782;Reactome: R-HSA-9033241	"Plasmalogen biosynthesis";"TYSND1 cleaves peroxisomal proteins";"Ether lipid metabolism";"Plasmalogen biosynthesis";"Peroxisomal protein import"
XP_053947256.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_053959763.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_053960935.1	7	Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5626467;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
XP_053947815.1	1	Reactome: R-HSA-5635838	"Activation of SMO"
XP_053965732.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053956437.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053960836.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_053969966.1	1	Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis"
XP_053967179.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_053964861.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053961850.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053952185.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053969955.1	3	Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916	"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium"
XP_053958349.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053966812.1	7	MetaCyc: PWY-3561;Reactome: R-HSA-1483166;KEGG: 00565+3.1.4.4;Reactome: R-HSA-2029485;MetaCyc: PWY-7039;Reactome: R-HSA-1483148;KEGG: 00564+3.1.4.4	"Choline biosynthesis III";"Synthesis of PA";"Ether lipid metabolism";"Role of phospholipids in phagocytosis";"Phosphatidate metabolism, as a signaling molecule";"Synthesis of PG";"Glycerophospholipid metabolism"
XP_053951360.1	1	Reactome: R-HSA-381038	"XBP1(S) activates chaperone genes"
XP_053966819.1	8	Reactome: R-HSA-111463;Reactome: R-HSA-9627069;Reactome: R-HSA-6798695;Reactome: R-HSA-111458;Reactome: R-HSA-8953750;Reactome: R-HSA-6803207;Reactome: R-HSA-111459;Reactome: R-HSA-111464	"SMAC (DIABLO) binds to IAPs";"Regulation of the apoptosome activity";"Neutrophil degranulation";"Formation of apoptosome";"Transcriptional Regulation by E2F6";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Activation of caspases through apoptosome-mediated cleavage";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes"
XP_053945360.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053950649.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_053959149.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053964747.1	6	Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-912446	"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Meiotic recombination"
XP_053951368.1	4	KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3	"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism"
XP_053964571.1	8	KEGG: 00710+5.3.1.6;KEGG: 00030+5.3.1.6;MetaCyc: PWY-1861;Reactome: R-HSA-5659996;KEGG: 00051+5.3.1.6;Reactome: R-HSA-6791461;MetaCyc: PWY-5723;Reactome: R-HSA-71336	"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"RPIA deficiency: failed conversion of R5P to RU5P";"Fructose and mannose metabolism";"RPIA deficiency: failed conversion of RU5P to R5P";"Rubisco shunt";"Pentose phosphate pathway"
XP_053947402.1	4	MetaCyc: PWY-7119;MetaCyc: PWY-6483;Reactome: R-HSA-1660662;KEGG: 00600+3.5.1.23	"Ceramide and sphingolipid recycling and degradation (yeast)";"Ceramide degradation (generic)";"Glycosphingolipid metabolism";"Sphingolipid metabolism"
XP_053962101.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_053949811.1	2	Reactome: R-HSA-2564830;Reactome: R-HSA-5693554	"Cytosolic iron-sulfur cluster assembly";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_053951526.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053950864.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_053945526.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-202427;Reactome: R-HSA-6807004	"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity"
XP_053965129.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_053945368.1	7	Reactome: R-HSA-2894862;Reactome: R-HSA-2660826;Reactome: R-HSA-2691232;Reactome: R-HSA-2644606;Reactome: R-HSA-2122948;Reactome: R-HSA-1442490;Reactome: R-HSA-177929	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Collagen degradation";"Signaling by EGFR"
XP_053956362.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053967211.1	29	Reactome: R-HSA-167246;Reactome: R-HSA-5696395;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-5696400;Reactome: R-HSA-167161;Reactome: R-HSA-73772;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-73863;Reactome: R-HSA-113418;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-427413;Reactome: R-HSA-75955;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-73762;Reactome: R-HSA-167162;Reactome: R-HSA-167160;Reactome: R-HSA-77075;Reactome: R-HSA-167152	"Tat-mediated elongation of the HIV-1 transcript";"Formation of Incision Complex in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Dual Incision in GG-NER";"HIV Transcription Initiation";"RNA Polymerase I Promoter Escape";"RNA Polymerase II Promoter Escape";"mRNA Capping";"RNA Polymerase I Transcription Termination";"Formation of the Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Elongation";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV elongation complex in the absence of HIV Tat"
XP_053961977.1	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
XP_053965543.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053966852.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_053953172.1	11	KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-163615;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-164378;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-418597	"Purine metabolism";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"G alpha (i) signalling events";"PKA activation in glucagon signalling";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events"
XP_053945106.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_053959827.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053964063.1	56	Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5689603;Reactome: R-HSA-174084;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5610783;Reactome: R-HSA-69017;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-69481;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880	"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"UCH proteinases";"Autodegradation of Cdh1 by Cdh1:APC/C";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Neddylation";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of DVL";"Degradation of AXIN";"Hedgehog ligand biogenesis";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"Degradation of GLI2 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"G2/M Checkpoints";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases"
XP_053961858.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_053953251.1	8	Reactome: R-HSA-196025;Reactome: R-HSA-5099900;Reactome: R-HSA-3928665;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-5140745;Reactome: R-HSA-190873;Reactome: R-HSA-432720	"Formation of annular gap junctions";"WNT5A-dependent internalization of FZD4";"EPH-ephrin mediated repulsion of cells";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Gap junction degradation";"Lysosome Vesicle Biogenesis"
XP_053966613.1	6	Reactome: R-HSA-1660499;KEGG: 00562+3.1.3.64+3.1.3.95;MetaCyc: PWY-6368;MetaCyc: PWY-6367;MetaCyc: PWY-6580;KEGG: 04070+3.1.3.64+3.1.3.95	"Synthesis of PIPs at the plasma membrane";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol biosynthesis I (bacteria)";"Phosphatidylinositol signaling system"
XP_053965874.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053967996.1	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053952155.1	5	KEGG: 00513+2.4.1.68;Reactome: R-HSA-975578;KEGG: 00533+2.4.1.68;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.68	"Various types of N-glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway";"Glycosaminoglycan biosynthesis - keratan sulfate";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis"
XP_053961139.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-4090294	"Nuclear Receptor transcription pathway";"SUMOylation of intracellular receptors"
XP_053949881.1	6	MetaCyc: PWY-5653;MetaCyc: PWY-5381;KEGG: 00760+6.3.5.1;MetaCyc: PWY-7761;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807	"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
XP_053962249.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_053952166.1	3	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221;Reactome: R-HSA-420029	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Tight junction interactions"
XP_053949533.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053950415.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053953153.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053961161.1	1	Reactome: R-HSA-3000471	"Scavenging by Class B Receptors"
XP_053965908.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_053968122.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_053958699.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_053954381.1	15	Reactome: R-HSA-70171;MetaCyc: PWY-7383;MetaCyc: PWY-5723;KEGG: 00010+2.7.1.40;MetaCyc: PWY-2221;MetaCyc: PWY-8004;MetaCyc: PWY-5484;MetaCyc: PWY-7003;KEGG: 00230+2.7.1.40;MetaCyc: PWY-1042;MetaCyc: PWY-6886;MetaCyc: PWY-6142;KEGG: 00620+2.7.1.40;MetaCyc: PWY-7218;MetaCyc: PWY-6901	"Glycolysis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Rubisco shunt";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Entner-Doudoroff pathway I";"Glycolysis II (from fructose 6-phosphate)";"Glycerol degradation to butanol";"Purine metabolism";"Glycolysis IV (plant cytosol)";"1-butanol autotrophic biosynthesis (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pyruvate metabolism";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Superpathway of glucose and xylose degradation"
XP_053949703.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_053964158.1	16	Reactome: R-HSA-2559582;Reactome: R-HSA-174084;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-176407;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-141430;Reactome: R-HSA-8853884;Reactome: R-HSA-2467813;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-174048;Reactome: R-HSA-176408	"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Transcriptional Regulation by VENTX";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase"
XP_053961729.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053967296.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053955303.1	13	Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_053955086.1	3	Reactome: R-HSA-1237112;KEGG: 00270+1.13.11.54;MetaCyc: PWY-4361	"Methionine salvage pathway";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053962903.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_053964895.1	5	Reactome: R-HSA-2426168;MetaCyc: PWY-7391;KEGG: 00900+2.7.4.2;Reactome: R-HSA-191273;MetaCyc: PWY-922	"Activation of gene expression by SREBF (SREBP)";"Isoprene biosynthesis II (engineered)";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"Mevalonate pathway I"
XP_053954469.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053950399.1	17	Reactome: R-HSA-176187;Reactome: R-HSA-1221632;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5685938;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6796648;Reactome: R-HSA-6783310;Reactome: R-HSA-69473;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693616;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-3371453;KEGG: 04151+2.7.11.1	"Activation of ATR in response to replication stress";"Meiotic synapsis";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Human cytomegalovirus infection";"HDR through Single Strand Annealing (SSA)";"Thermogenesis";"Human immunodeficiency virus 1 infection";"TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway";"G2/M DNA damage checkpoint";"Relaxin signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"mTOR signaling pathway";"Human papillomavirus infection";"Regulation of HSF1-mediated heat shock response";"PI3K-Akt signaling pathway"
XP_053954462.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053947885.1	3	Reactome: R-HSA-8951664;Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Neddylation";"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053956894.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_053946427.1	2	Reactome: R-HSA-204005;Reactome: R-HSA-5694530	"COPII-mediated vesicle transport";"Cargo concentration in the ER"
XP_053965900.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053949896.1	6	MetaCyc: PWY-7761;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807;MetaCyc: PWY-5653;MetaCyc: PWY-5381;KEGG: 00760+6.3.5.1	"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism"
XP_053967630.1	7	KEGG: 00190+7.1.2.2;Reactome: R-HSA-8949613;Reactome: R-HSA-2151201;Reactome: R-HSA-1268020;KEGG: 00195+7.1.2.2;MetaCyc: PWY-7980;Reactome: R-HSA-163210	"Oxidative phosphorylation";"Cristae formation";"Transcriptional activation of mitochondrial biogenesis";"Mitochondrial protein import";"Photosynthesis";"ATP biosynthesis";"Formation of ATP by chemiosmotic coupling"
XP_053950809.1	2	Reactome: R-HSA-1299308;Reactome: R-HSA-5576886	"Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)";"Phase 4 - resting membrane potential"
XP_053953281.1	29	Reactome: R-HSA-167246;Reactome: R-HSA-5696395;Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-75953;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-73772;Reactome: R-HSA-112382;Reactome: R-HSA-167161;Reactome: R-HSA-5696400;Reactome: R-HSA-73863;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-113418;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-167162;Reactome: R-HSA-6781827;Reactome: R-HSA-73762;Reactome: R-HSA-75955;Reactome: R-HSA-427413;Reactome: R-HSA-76042;Reactome: R-HSA-167160;Reactome: R-HSA-77075;Reactome: R-HSA-167152	"Tat-mediated elongation of the HIV-1 transcript";"Formation of Incision Complex in GG-NER";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase I Promoter Escape";"Formation of RNA Pol II elongation complex";"HIV Transcription Initiation";"Dual Incision in GG-NER";"RNA Polymerase I Transcription Termination";"mRNA Capping";"RNA Polymerase II Promoter Escape";"Formation of the Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"RNA Polymerase II HIV Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Elongation";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV elongation complex in the absence of HIV Tat"
XP_053965654.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053947464.1	6	KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_053965795.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053969098.1	7	KEGG: 00600+2.4.1.80;MetaCyc: PWY-7838;Reactome: R-HSA-1660662;MetaCyc: PWY-7839;MetaCyc: PWY-7836;MetaCyc: PWY-5129;MetaCyc: PWY-7841	"Sphingolipid metabolism";"Globo-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism";"Lacto-series glycosphingolipids biosynthesis";"Ganglio-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)";"Neolacto-series glycosphingolipids biosynthesis"
XP_053950028.1	12	Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-3371497;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-5663220;Reactome: R-HSA-6807878;Reactome: R-HSA-141444	"HCMV Early Events";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"COPI-mediated anterograde transport";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_053966882.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
XP_053966867.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053950466.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053945726.1	14	MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433	"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)"
XP_053961228.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-6794361;Reactome: R-HSA-8856828;Reactome: R-HSA-5250958	"Cargo recognition for clathrin-mediated endocytosis";"Neurexins and neuroligins";"Clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)"
XP_053966385.1	9	KEGG: 00020+6.4.1.1;Reactome: R-HSA-3371599;MetaCyc: PWY-8086;Reactome: R-HSA-70263;Reactome: R-HSA-196780;KEGG: 00620+6.4.1.1;KEGG: 00720+6.4.1.1;MetaCyc: PWY-6142;MetaCyc: PWY-6146	"Citrate cycle (TCA cycle)";"Defective HLCS causes multiple carboxylase deficiency";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis";"Biotin transport and metabolism";"Pyruvate metabolism";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Methanobacterium thermoautotrophicum biosynthetic metabolism"
XP_053956093.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053959917.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053946324.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_053949248.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation"
XP_053966229.1	10	KEGG: 00604+3.2.1.23;Reactome: R-HSA-2024096;KEGG: 00531+3.2.1.23;Reactome: R-HSA-6798695;MetaCyc: PWY-6807;Reactome: R-HSA-2160916;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2206292	"Glycosphingolipid biosynthesis - ganglio series";"HS-GAG degradation";"Glycosaminoglycan degradation";"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Hyaluronan uptake and degradation";"Galactose metabolism";"Other glycan degradation";"Sphingolipid metabolism";"MPS VII - Sly syndrome"
XP_053958472.1	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
XP_053958333.1	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
XP_053964455.1	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
XP_053966222.1	10	KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;Reactome: R-HSA-2160916;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2206292	"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"Neutrophil degranulation";"HS-GAG degradation";"Hyaluronan uptake and degradation";"Other glycan degradation";"Galactose metabolism";"Sphingolipid metabolism";"MPS VII - Sly syndrome"
XP_053952418.1	2	Reactome: R-HSA-8866654;Reactome: R-HSA-9033241	"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import"
XP_053951726.1	3	Reactome: R-HSA-8868766;Reactome: R-HSA-6785470;Reactome: R-HSA-6784531	"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion";"tRNA processing in the nucleus"
XP_053964399.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053947382.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387	"Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling"
XP_053947367.1	2	Reactome: R-HSA-189451;KEGG: 00860+4.99.1.1	"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_053949884.1	6	KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807;MetaCyc: PWY-7761;KEGG: 00760+6.3.5.1;MetaCyc: PWY-5381;MetaCyc: PWY-5653	"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde"
XP_053959204.1	22	MetaCyc: PWY-7726;MetaCyc: PWY-7049;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7592;MetaCyc: PWY-6958;MetaCyc: PWY-7602;MetaCyc: PWY-7728;MetaCyc: PWY-6433;MetaCyc: PWY-7601;MetaCyc: PWY-7035;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7053;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5353;MetaCyc: PWY-7619;MetaCyc: PWY-7724;MetaCyc: PWY-6598;MetaCyc: PWY-7727;MetaCyc: PWY-7606;Reactome: R-HSA-75876	"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Sciadonate biosynthesis";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs"
XP_053947389.1	3	MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2;Reactome: R-HSA-1650814	"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism";"Collagen biosynthesis and modifying enzymes"
XP_053946206.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053964392.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053968238.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053967284.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_053950158.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_053951323.1	27	Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-3301854;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-168333;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-4551638;Reactome: R-HSA-170822	"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein"
XP_053947225.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_053950044.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862	"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053963992.1	13	MetaCyc: PWY-7721;MetaCyc: PWY-6383;MetaCyc: PWY-5122;MetaCyc: PWY-6859;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-5123;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7182;MetaCyc: PWY-7709	"Methyl phomopsenoate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"All-trans-farnesol biosynthesis";"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Linalool biosynthesis I";"(3R)-linalool biosynthesis"
XP_053955845.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053968012.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport"
XP_053968230.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053960381.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053962187.1	2	Reactome: R-HSA-204626;MetaCyc: PWY-5905	"Hypusine synthesis from eIF5A-lysine";"Hypusine biosynthesis"
XP_053949948.1	2	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_053958483.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053952025.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053965651.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053965539.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053959650.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_053962070.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_053953284.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053966922.1	2	Reactome: R-HSA-5619039;Reactome: R-HSA-426117	"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)";"Cation-coupled Chloride cotransporters"
XP_053964415.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053962748.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053967821.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053945275.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053946906.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-2894862	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_053959904.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053947439.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053967840.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_053967984.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053953848.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053964041.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053944994.1	1	Reactome: R-HSA-6783984	"Glycine degradation"
XP_053947373.1	6	Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72649	"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation"
XP_053951275.1	5	Reactome: R-HSA-5685938;Reactome: R-HSA-5696400;Reactome: R-HSA-6783310;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135	"HDR through Single Strand Annealing (SSA)";"Dual Incision in GG-NER";"Fanconi Anemia Pathway";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER"
XP_053960337.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053950118.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_053965696.1	1	Reactome: R-HSA-71262	"Carnitine synthesis"
XP_053955126.1	2	Reactome: R-HSA-8866907;Reactome: R-HSA-8866904	"Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors"
XP_053954593.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_053967207.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053954897.1	3	Reactome: R-HSA-379716;Reactome: R-HSA-379726;KEGG: 00970+6.1.1.14	"Cytosolic tRNA aminoacylation";"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053947495.1	10	KEGG: 05165+2.7.1.153;KEGG: 00562+2.7.1.153;KEGG: 04070+2.7.1.153;KEGG: 04151+2.7.1.153;Reactome: R-HSA-1660499;KEGG: 05170+2.7.1.153;KEGG: 04150+2.7.1.153;Reactome: R-HSA-9027276;KEGG: 05163+2.7.1.153;MetaCyc: PWY-6352	"Human papillomavirus infection";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"PI3K-Akt signaling pathway";"Synthesis of PIPs at the plasma membrane";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"Human cytomegalovirus infection";"3-phosphoinositide biosynthesis"
XP_053959287.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053969146.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053958413.1	1	Reactome: R-HSA-1614635	"Sulfur amino acid metabolism"
XP_053962117.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_053962233.1	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
XP_053966763.1	6	Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-456926;Reactome: R-HSA-399997	"G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Thrombin signalling through proteinase activated receptors (PARs)";"Acetylcholine regulates insulin secretion"
XP_053956865.1	5	MetaCyc: PWY-6614;KEGG: 00670+1.5.1.3;KEGG: 00790+1.5.1.3;MetaCyc: PWY-3841;Reactome: R-HSA-196757	"Tetrahydrofolate biosynthesis";"One carbon pool by folate";"Folate biosynthesis";"Folate transformations II (plants)";"Metabolism of folate and pterines"
XP_053957935.1	29	MetaCyc: PWY-6802;KEGG: 00592+1.1.1.1;MetaCyc: PWY-6313;MetaCyc: PWY-5486;MetaCyc: PWY-5057;MetaCyc: PWY-7396;MetaCyc: PWY-6871;KEGG: 00626+1.1.1.1;KEGG: 00982+1.1.1.1;KEGG: 00980+1.1.1.1;MetaCyc: PWY-7111;MetaCyc: PWY-5480;MetaCyc: PWY-7118;MetaCyc: PWY-6333;KEGG: 00350+1.1.1.1;KEGG: 00260+1.1.1.1;KEGG: 00071+1.1.1.1;MetaCyc: PWY-5078;KEGG: 00010+1.1.1.1;MetaCyc: PWY-5751;MetaCyc: PWY-5079;MetaCyc: PWY-5076;KEGG: 00625+1.1.1.1;MetaCyc: PWY-6587;MetaCyc: PWY-5082;MetaCyc: PWY-6342;MetaCyc: PWY-7013;KEGG: 00830+1.1.1.1;MetaCyc: PWY-3162	"Salidroside biosynthesis";"alpha-Linolenic acid metabolism";"Serotonin degradation";"Pyruvate fermentation to ethanol II";"L-valine degradation II";"Butanol and isobutanol biosynthesis (engineered)";"3-methylbutanol biosynthesis (engineered)";"Naphthalene degradation";"Drug metabolism - cytochrome P450";"Metabolism of xenobiotics by cytochrome P450";"Pyruvate fermentation to isobutanol (engineered)";"Pyruvate fermentation to ethanol I";"Chitin degradation to ethanol";"Acetaldehyde biosynthesis I";"Tyrosine metabolism";"Glycine, serine and threonine metabolism";"Fatty acid degradation";"L-isoleucine degradation II";"Glycolysis / Gluconeogenesis";"Phenylethanol biosynthesis";"L-phenylalanine degradation III";"L-leucine degradation III";"Chloroalkane and chloroalkene degradation";"Pyruvate fermentation to ethanol III";"L-methionine degradation III";"Noradrenaline and adrenaline degradation";"(S)-propane-1,2-diol degradation";"Retinol metabolism";"L-tryptophan degradation V (side chain pathway)"
XP_053957429.1	7	Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;MetaCyc: PWY-7511;Reactome: R-HSA-2894862;Reactome: R-HSA-2979096;Reactome: R-HSA-2644606;Reactome: R-HSA-2691232	"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
XP_053961102.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053955797.1	14	MetaCyc: PWY-7601;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7725;MetaCyc: PWY-8041	"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis"
XP_053966492.1	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
XP_053964864.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053963176.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053956856.1	13	Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053964642.1	14	Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-8948700;Reactome: R-HSA-426486;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-203927	"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Small interfering RNA (siRNA) biogenesis";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"MicroRNA (miRNA) biogenesis"
XP_053964603.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053970226.1	3	Reactome: R-HSA-5358493;MetaCyc: PWY-6482;MetaCyc: PWY-7546	"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)"
XP_053953914.1	2	Reactome: R-HSA-3214847;Reactome: R-HSA-171319	"HATs acetylate histones";"Telomere Extension By Telomerase"
XP_053963429.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053953254.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053948323.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053963935.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053950180.1	2	Reactome: R-HSA-5205685;Reactome: R-HSA-983231	"Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production"
XP_053949674.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053959962.1	8	MetaCyc: PWY-5;Reactome: R-HSA-70635;KEGG: 00250+4.3.2.1;MetaCyc: PWY-4983;MetaCyc: PWY-7400;KEGG: 00220+4.3.2.1;MetaCyc: PWY-4984;MetaCyc: PWY-5154	"Canavanine biosynthesis";"Urea cycle";"Alanine, aspartate and glutamate metabolism";"Nitric oxide biosynthesis II (mammals)";"L-arginine biosynthesis IV (archaebacteria)";"Arginine biosynthesis";"Urea cycle";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)"
XP_053954314.1	3	Reactome: R-HSA-1358803;MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Downregulation of ERBB2:ERBB3 signaling";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053961490.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_053959969.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053966315.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053957235.1	16	Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation"
XP_053950861.1	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
XP_053965930.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_053957590.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053948726.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053965637.1	1	Reactome: R-HSA-9617828	"FOXO-mediated transcription of cell cycle genes"
XP_053966541.1	3	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
XP_053956816.1	3	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109	"Glycerol degradation I";"Glycerolipid metabolism";"Triglyceride biosynthesis"
XP_053954836.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053947312.1	4	Reactome: R-HSA-6799198;Reactome: R-HSA-975138;Reactome: R-HSA-975871;Reactome: R-HSA-166058	"Complex I biogenesis";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"MyD88 cascade initiated on plasma membrane";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane"
XP_053946478.1	15	MetaCyc: PWY-6901;MetaCyc: PWY-7218;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6142;MetaCyc: PWY-6886;MetaCyc: PWY-1042;KEGG: 00230+2.7.1.40;MetaCyc: PWY-7003;MetaCyc: PWY-5484;MetaCyc: PWY-8004;MetaCyc: PWY-2221;KEGG: 00010+2.7.1.40;MetaCyc: PWY-5723;MetaCyc: PWY-7383;Reactome: R-HSA-70171	"Superpathway of glucose and xylose degradation";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Pyruvate metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Purine metabolism";"Glycerol degradation to butanol";"Glycolysis II (from fructose 6-phosphate)";"Entner-Doudoroff pathway I";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Glycolysis / Gluconeogenesis";"Rubisco shunt";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis"
XP_053955355.1	3	Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067	"Glycogen synthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)"
XP_053963137.1	10	MetaCyc: PWY-6372;Reactome: R-HSA-1855167;Reactome: R-HSA-1855191;KEGG: 04070+2.7.1.158;MetaCyc: PWY-4661;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6554;MetaCyc: PWY-6362;MetaCyc: PWY-6361;MetaCyc: PWY-6369	"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of pyrophosphates in the cytosol";"Synthesis of IPs in the nucleus";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Inositol diphosphates biosynthesis"
XP_053954604.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-380284	"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_053967310.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053962966.1	1	Reactome: R-HSA-2142789	"Ubiquinol biosynthesis"
XP_053951425.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_053951932.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053969548.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_053966605.1	4	Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48	"Pyrimidine salvage";"Drug metabolism - other enzymes";"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism"
XP_053946529.1	4	Reactome: R-HSA-4720489;KEGG: 00510+2.4.1.260;Reactome: R-HSA-446193;KEGG: 00513+2.4.1.260	"Defective ALG12 causes ALG12-CDG (CDG-1g)";"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis"
XP_053964765.1	57	Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-174184;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-4641258;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641257;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-9604323;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-4608870;Reactome: R-HSA-450408;Reactome: R-HSA-180534;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-6798695;Reactome: R-HSA-382556;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-174178;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-69481	"Downstream TCR signaling";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Degradation of DVL";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of AXIN";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"Negative regulation of NOTCH4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Asymmetric localization of PCP proteins";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vpu mediated degradation of CD4";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Neutrophil degranulation";"ABC-family proteins mediated transport";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"G2/M Checkpoints"
XP_053963860.1	5	KEGG: 00520+2.6.1.16;KEGG: 00250+2.6.1.16;MetaCyc: PWY-8013;MetaCyc: PWY-6749;Reactome: R-HSA-446210	"Amino sugar and nucleotide sugar metabolism";"Alanine, aspartate and glutamate metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis III";"CMP-legionaminate biosynthesis I";"Synthesis of UDP-N-acetyl-glucosamine"
XP_053945932.1	6	KEGG: 00670+2.1.2.3;Reactome: R-HSA-73817;KEGG: 00230+3.5.4.10+2.1.2.3;MetaCyc: PWY-6123;MetaCyc: PWY-7234;MetaCyc: PWY-6124	"One carbon pool by folate";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis II"
XP_053954863.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053949694.1	4	Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_053959185.1	5	Reactome: R-HSA-70895;KEGG: 00640+1.2.4.4;KEGG: 00280+1.2.4.4;MetaCyc: PWY-5046;Reactome: R-HSA-389661	"Branched-chain amino acid catabolism";"Propanoate metabolism";"Valine, leucine and isoleucine degradation";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Glyoxylate metabolism and glycine degradation"
XP_053952234.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling"
XP_053957196.1	4	Reactome: R-HSA-111465;Reactome: R-HSA-5693607;Reactome: R-HSA-5689880;Reactome: R-HSA-176187	"Apoptotic cleavage of cellular proteins";"Processing of DNA double-strand break ends";"Ub-specific processing proteases";"Activation of ATR in response to replication stress"
XP_053954582.1	5	Reactome: R-HSA-380994;Reactome: R-HSA-9614657;Reactome: R-HSA-2426168;Reactome: R-HSA-381183;Reactome: R-HSA-1989781	"ATF4 activates genes in response to endoplasmic reticulum stress";"FOXO-mediated transcription of cell death genes";"Activation of gene expression by SREBF (SREBP)";"ATF6 (ATF6-alpha) activates chaperone genes";"PPARA activates gene expression"
XP_053962955.1	3	KEGG: 00561+3.1.1.23;Reactome: R-HSA-426048;MetaCyc: PWY-7420	"Glycerolipid metabolism";"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)"
XP_053949766.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053945939.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_053960752.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_053948700.1	9	Reactome: R-HSA-110357;Reactome: R-HSA-5649702;Reactome: R-HSA-9656256;Reactome: R-HSA-110329;Reactome: R-HSA-9657050;Reactome: R-HSA-110331;Reactome: R-HSA-110330;Reactome: R-HSA-110328;Reactome: R-HSA-9656255	"Displacement of DNA glycosylase by APEX1";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway";"Defective OGG1 Substrate Processing";"Cleavage of the damaged pyrimidine";"Defective OGG1 Localization";"Cleavage of the damaged purine";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective OGG1 Substrate Binding"
XP_053953350.1	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
XP_053964353.1	13	KEGG: 00670+6.3.4.3;MetaCyc: PWY-5030;KEGG: 00720+6.3.4.3;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-1722;MetaCyc: PWY-2161;MetaCyc: PWY-5497;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;MetaCyc: PWY-2201;MetaCyc: PWY-6613;MetaCyc: PWY-7909;Reactome: R-HSA-196757	"One carbon pool by folate";"L-histidine degradation III";"Carbon fixation pathways in prokaryotes";"One carbon pool by folate";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate polyglutamylation";"Purine nucleobases degradation II (anaerobic)";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Folate transformations I";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"Metabolism of folate and pterines"
XP_053958435.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_053950449.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_053945961.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053958929.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_053966506.1	4	Reactome: R-HSA-2173789;Reactome: R-HSA-2173788;Reactome: R-HSA-3656532;Reactome: R-HSA-3304356	"TGF-beta receptor signaling activates SMADs";"Downregulation of TGF-beta receptor signaling";"TGFBR1 KD Mutants in Cancer";"SMAD2/3 Phosphorylation Motif Mutants in Cancer"
XP_053954657.1	2	Reactome: R-HSA-1483115;Reactome: R-HSA-1483152	"Hydrolysis of LPC";"Hydrolysis of LPE"
XP_053968301.1	12	MetaCyc: PWY-1861;KEGG: 00710+4.1.2.13;MetaCyc: PWY-5484;MetaCyc: PWY-7385;Reactome: R-HSA-70263;MetaCyc: PWY-1042;KEGG: 00051+4.1.2.13;MetaCyc: PWY-6142;Reactome: R-HSA-70171;KEGG: 00680+4.1.2.13;KEGG: 00030+4.1.2.13;KEGG: 00010+4.1.2.13	"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Carbon fixation in photosynthetic organisms";"Glycolysis II (from fructose 6-phosphate)";"1,3-propanediol biosynthesis (engineered)";"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Fructose and mannose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis";"Methane metabolism";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis"
XP_053965865.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_053957727.1	10	Reactome: R-HSA-5693568;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5693579;Reactome: R-HSA-5685938;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-912446;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"Homologous DNA Pairing and Strand Exchange";"HDR through Single Strand Annealing (SSA)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Meiotic recombination";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_053966483.1	20	Reactome: R-HSA-5693616;Reactome: R-HSA-69473;Reactome: R-HSA-6782135;Reactome: R-HSA-69091;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-6782210;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-5693607;Reactome: R-HSA-110314;Reactome: R-HSA-5685938;Reactome: R-HSA-5655862;Reactome: R-HSA-176187;Reactome: R-HSA-6804756;Reactome: R-HSA-5696400;Reactome: R-HSA-110320;Reactome: R-HSA-5656121	"Presynaptic phase of homologous DNA pairing and strand exchange";"G2/M DNA damage checkpoint";"Dual incision in TC-NER";"Polymerase switching";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"Processing of DNA double-strand break ends";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Single Strand Annealing (SSA)";"Translesion synthesis by POLK";"Activation of ATR in response to replication stress";"Regulation of TP53 Activity through Phosphorylation";"Dual Incision in GG-NER";"Translesion Synthesis by POLH";"Translesion synthesis by POLI"
XP_053951010.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-983231	"Mitochondrial calcium ion transport";"Factors involved in megakaryocyte development and platelet production"
XP_053954950.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_053955492.1	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
XP_053957578.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-8869496	"rRNA modification in the nucleus and cytosol";"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"
XP_053949715.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053965676.1	6	MetaCyc: PWY-7900;MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085;MetaCyc: PWY-622;KEGG: 00500+2.4.1.18	"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate";"Starch biosynthesis";"Starch and sucrose metabolism"
XP_053947751.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053964716.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053956019.1	2	Reactome: R-HSA-8983711;Reactome: R-HSA-909733	"OAS antiviral response";"Interferon alpha/beta signaling"
XP_053969101.1	7	MetaCyc: PWY-7838;KEGG: 00600+2.4.1.80;MetaCyc: PWY-7839;MetaCyc: PWY-7836;MetaCyc: PWY-5129;MetaCyc: PWY-7841;Reactome: R-HSA-1660662	"Globo-series glycosphingolipids biosynthesis";"Sphingolipid metabolism";"Lacto-series glycosphingolipids biosynthesis";"Ganglio-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)";"Neolacto-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism"
XP_053948295.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_053945232.1	4	Reactome: R-HSA-2243919;Reactome: R-HSA-1650814;Reactome: R-HSA-2214320;Reactome: R-HSA-1474228	"Crosslinking of collagen fibrils";"Collagen biosynthesis and modifying enzymes";"Anchoring fibril formation";"Degradation of the extracellular matrix"
XP_053957181.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053962915.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_053945239.1	4	Reactome: R-HSA-1650814;Reactome: R-HSA-2243919;Reactome: R-HSA-1474228;Reactome: R-HSA-2214320	"Collagen biosynthesis and modifying enzymes";"Crosslinking of collagen fibrils";"Degradation of the extracellular matrix";"Anchoring fibril formation"
XP_053963727.1	6	KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_053962255.1	2	Reactome: R-HSA-8849175;KEGG: 00260+2.3.1.29	"Threonine catabolism";"Glycine, serine and threonine metabolism"
XP_053969540.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053968454.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053954617.1	7	KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1	"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection"
XP_053956637.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876	"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing"
XP_053969521.1	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
XP_053963253.1	6	Reactome: R-HSA-189085;MetaCyc: PWY-7900;KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;MetaCyc: PWY-622;KEGG: 00500+2.4.1.18	"Digestion of dietary carbohydrate";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch biosynthesis";"Starch and sucrose metabolism"
XP_053951050.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_053954061.1	12	Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-9013695;Reactome: R-HSA-1912408;Reactome: R-HSA-2894862;Reactome: R-HSA-3214847;Reactome: R-HSA-210744;Reactome: R-HSA-2122947;Reactome: R-HSA-9013508;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"NOTCH4 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"HATs acetylate histones";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH3 Intracellular Domain Regulates Transcription";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"Notch-HLH transcription pathway"
XP_053958777.1	3	KEGG: 00310+2.1.1.60;Reactome: R-HSA-2514859;Reactome: R-HSA-8876725	"Lysine degradation";"Inactivation, recovery and regulation of the phototransduction cascade";"Protein methylation"
XP_053948261.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053953438.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053947849.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053962985.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053957283.1	8	Reactome: R-HSA-74217;Reactome: R-HSA-6798695;KEGG: 00230+3.5.4.4;MetaCyc: PWY-6609;MetaCyc: PWY-6611;Reactome: R-HSA-5683826;MetaCyc: PWY-7179-1;MetaCyc: PWY-7179	"Purine salvage";"Neutrophil degranulation";"Purine metabolism";"Adenine and adenosine salvage III";"Adenine and adenosine salvage V";"Surfactant metabolism";"Purine deoxyribonucleosides degradation II";"Purine deoxyribonucleosides degradation I"
XP_053955222.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053956089.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053969724.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053957972.1	3	Reactome: R-HSA-189451;MetaCyc: PWY-7856;KEGG: 00860+2.5.1.141	"Heme biosynthesis";"Heme a biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_053956082.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053952201.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions"
XP_053947796.1	18	MetaCyc: PWY-7221;MetaCyc: PWY-7222;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7220;MetaCyc: PWY-7198;MetaCyc: PWY-7205;MetaCyc: PWY-7224;MetaCyc: PWY-7210;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7227;MetaCyc: PWY-7176;Reactome: R-HSA-499943;MetaCyc: PWY-6545;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7226;MetaCyc: PWY-7197;MetaCyc: PWY-7187;MetaCyc: PWY-7184	"Guanosine ribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"CMP phosphorylation";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis";"UTP and CTP de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I"
XP_053958520.1	3	Reactome: R-HSA-3299685;KEGG: 00230+3.6.1.17;KEGG: 00240+3.6.1.17	"Detoxification of Reactive Oxygen Species";"Purine metabolism";"Pyrimidine metabolism"
XP_053963983.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053946920.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053966845.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053951163.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053950556.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053953380.1	14	KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7783;KEGG: 00565+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-7417;MetaCyc: PWY-8053;Reactome: R-HSA-1482788;Reactome: R-HSA-975634	"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Plasmalogen degradation";"Ether lipid metabolism";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PC";"Retinoid metabolism and transport"
XP_053965886.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053947127.1	3	Reactome: R-HSA-913709;Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"O-linked glycosylation of mucins";"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
XP_053947393.1	4	KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-6483;MetaCyc: PWY-7119	"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)"
XP_053963272.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053966094.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053965301.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053945538.1	3	Reactome: R-HSA-156590;Reactome: R-HSA-204174;Reactome: R-HSA-8963684	"Glutathione conjugation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Tyrosine catabolism"
XP_053954512.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_053956532.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_053950615.1	3	KEGG: 00250+3.5.1.1;KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693	"Alanine, aspartate and glutamate metabolism";"Cyanoamino acid metabolism";"Aspartate and asparagine metabolism"
XP_053956539.1	5	MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6317	"D-galactose detoxification";"Galactose metabolism";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)"
XP_053946928.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053969134.1	6	Reactome: R-HSA-4086398;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-4411364;Reactome: R-HSA-3769402;Reactome: R-HSA-8951430	"Ca2+ pathway";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex";"RUNX3 regulates WNT signaling"
XP_053954988.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053962285.1	5	Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-75035;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897	"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes"
XP_053957272.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053951700.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053963024.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053953388.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_053950516.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_053960841.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053945177.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_053950875.1	5	Reactome: R-HSA-174403;Reactome: R-HSA-5579006;MetaCyc: PWY-8043;KEGG: 00270+6.3.2.3;KEGG: 00480+6.3.2.3	"Glutathione synthesis and recycling";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Ophthalmate biosynthesis";"Cysteine and methionine metabolism";"Glutathione metabolism"
XP_053953430.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053966413.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053968484.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053946241.1	14	Reactome: R-HSA-167242;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-113418;Reactome: R-HSA-167290	"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"Formation of the Early Elongation Complex";"Pausing and recovery of HIV elongation"
XP_053951995.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053963972.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_053952568.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053946880.1	6	MetaCyc: PWY-6608;Reactome: R-HSA-74259;MetaCyc: PWY-6606;MetaCyc: PWY-7442;MetaCyc: PWY-5497;KEGG: 00230+3.5.4.3	"Guanosine nucleotides degradation III";"Purine catabolism";"Guanosine nucleotides degradation II";"Drosopterin and aurodrosopterin biosynthesis";"Purine nucleobases degradation II (anaerobic)";"Purine metabolism"
XP_053953725.1	4	Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72764	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination"
XP_053950372.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053958405.1	11	Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-6804756;Reactome: R-HSA-5693568;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5358565;Reactome: R-HSA-5358606	"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"
XP_053950433.1	13	KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916;MetaCyc: PWY-7822;KEGG: 00603+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;KEGG: 00511+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52	"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Keratan sulfate degradation";"Hyaluronan uptake and degradation";"Chitin degradation III (Serratia)";"Glycosphingolipid biosynthesis - globo and isoglobo series";"CS/DS degradation";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Other glycan degradation";"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
XP_053957778.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053948730.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_053946132.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053964875.1	3	KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3	"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis"
XP_053954773.1	10	MetaCyc: PWY-4321;Reactome: R-HSA-916853;MetaCyc: PWY-6535;MetaCyc: PWY-5022;MetaCyc: PWY-6536;KEGG: 00640+2.6.1.19;KEGG: 00650+2.6.1.19;KEGG: 00410+2.6.1.19;MetaCyc: PWY-6537;KEGG: 00250+2.6.1.19	"L-glutamate degradation IV";"Degradation of GABA";"4-aminobutanoate degradation I";"4-aminobutanoate degradation V";"4-aminobutanoate degradation III";"Propanoate metabolism";"Butanoate metabolism";"beta-Alanine metabolism";"4-aminobutanoate degradation II";"Alanine, aspartate and glutamate metabolism"
XP_053946139.1	4	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Ion channel transport"
XP_053950379.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053969721.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053948128.1	10	KEGG: 00670+2.1.1.45;Reactome: R-HSA-499943;MetaCyc: PWY-7198;Reactome: R-HSA-69205;KEGG: 00240+2.1.1.45;MetaCyc: PWY-7184;MetaCyc: PWY-7187;MetaCyc: PWY-7199;MetaCyc: PWY-3841;MetaCyc: PWY-7210	"One carbon pool by folate";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"G1/S-Specific Transcription";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleosides salvage";"Folate transformations II (plants)";"Pyrimidine deoxyribonucleotides biosynthesis from CTP"
XP_053961340.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053945909.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053952204.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_053946161.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053969740.1	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
XP_053960519.1	42	Reactome: R-HSA-427359;Reactome: R-HSA-5578749;Reactome: R-HSA-5693607;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-1912408;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-110331;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-69473;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-2299718;Reactome: R-HSA-427413;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-3214815;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-5334118;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-110329;Reactome: R-HSA-5693565;Reactome: R-HSA-977225;Reactome: R-HSA-5693571;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-9018519;Reactome: R-HSA-912446;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-201722	"SIRT1 negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Processing of DNA double-strand break ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Pre-NOTCH Transcription and Translation";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Cleavage of the damaged purine";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"G2/M DNA damage checkpoint";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"Condensation of Prophase Chromosomes";"NoRC negatively regulates rRNA expression";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"HDACs deacetylate histones";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"DNA methylation";"Meiotic synapsis";"Packaging Of Telomere Ends";"Cleavage of the damaged pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Amyloid fiber formation";"Nonhomologous End-Joining (NHEJ)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Estrogen-dependent gene expression";"Meiotic recombination";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex"
XP_053954376.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053960988.1	5	KEGG: 00760+6.3.4.21;Reactome: R-HSA-197264;Reactome: R-HSA-1368108;MetaCyc: PWY-5381;Reactome: R-HSA-6798695	"Nicotinate and nicotinamide metabolism";"Nicotinamide salvaging";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Pyridine nucleotide cycling (plants)";"Neutrophil degranulation"
XP_053964615.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_053970230.1	5	KEGG: 04070+2.7.7.41;MetaCyc: PWY-5667;MetaCyc: PWY-5981;KEGG: 00564+2.7.7.41;MetaCyc: PWY-7817	"Phosphatidylinositol signaling system";"CDP-diacylglycerol biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_053959450.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_053952870.1	1	Reactome: R-HSA-5666185	"RHO GTPases Activate Rhotekin and Rhophilins"
XP_053946244.1	1	MetaCyc: PWY-7437	"Protein O-[N-acetyl]-glucosylation"
XP_053952957.1	3	Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916	"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium"
XP_053960662.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053964565.1	3	Reactome: R-HSA-3214858;Reactome: R-HSA-191859;Reactome: R-HSA-6804760	"RMTs methylate histone arginines";"snRNP Assembly";"Regulation of TP53 Activity through Methylation"
XP_053969187.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053961348.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053946722.1	5	Reactome: R-HSA-72163;Reactome: R-HSA-159231;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"Transport of Mature mRNA Derived from an Intronless Transcript";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
XP_053950383.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053952217.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053952878.1	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
XP_053956607.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053965226.1	4	Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-983712	"Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Ion channel transport"
XP_053966342.1	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
XP_053963114.1	6	Reactome: R-HSA-174437;Reactome: R-HSA-162594;Reactome: R-HSA-69166;Reactome: R-HSA-5651801;Reactome: R-HSA-5685939;Reactome: R-HSA-110362	"Removal of the Flap Intermediate from the C-strand";"Early Phase of HIV Life Cycle";"Removal of the Flap Intermediate";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through MMEJ (alt-NHEJ)";"POLB-Dependent Long Patch Base Excision Repair"
XP_053952650.1	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
XP_053953135.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_053955071.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_053957107.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_053954828.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053952904.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053963021.1	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
XP_053946888.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053945243.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_053945209.1	4	Reactome: R-HSA-5696394;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823	"DNA Damage Recognition in GG-NER";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex"
XP_053951243.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053958672.1	8	KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6791226	"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_053965304.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053956654.1	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
XP_053969131.1	6	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-4086398;Reactome: R-HSA-8951430;Reactome: R-HSA-4411364;Reactome: R-HSA-3769402	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Ca2+ pathway";"RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex"
XP_053954009.1	4	Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"MHC class II antigen presentation";"RHO GTPases activate KTN1";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053951202.1	18	KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00592+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;Reactome: R-HSA-1482801;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482839;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925;MetaCyc: PWY-7417;MetaCyc: PWY-8053	"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"Acyl chain remodelling of PS";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PE";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II"
XP_053951964.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_053948243.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_053964591.1	13	MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-6383;MetaCyc: PWY-5122;MetaCyc: PWY-6859;MetaCyc: PWY-7721;MetaCyc: PWY-7709;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-7182;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-5123	"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"All-trans-farnesol biosynthesis";"Methyl phomopsenoate biosynthesis";"(3R)-linalool biosynthesis";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"Linalool biosynthesis I";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis"
XP_053960250.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053952262.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053961236.1	4	Reactome: R-HSA-5250958;Reactome: R-HSA-6794361;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Toxicity of botulinum toxin type B (BoNT/B)";"Neurexins and neuroligins";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053949035.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053946850.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_053947178.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053958130.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053954712.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_053946678.1	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
XP_053966016.1	2	Reactome: R-HSA-8950505;Reactome: R-HSA-1237112	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Methionine salvage pathway"
XP_053959338.1	4	Reactome: R-HSA-2029482;Reactome: R-HSA-8856828;Reactome: R-HSA-3928662;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs"
XP_053954719.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053970082.1	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
XP_053963629.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053958728.1	5	MetaCyc: PWY-5514;MetaCyc: PWY-6855;MetaCyc: PWY-6906;Reactome: R-HSA-70171;KEGG: 00520+3.5.99.6	"UDP-N-acetyl-D-galactosamine biosynthesis II";"Chitin degradation I (archaea)";"Chitin derivatives degradation";"Glycolysis";"Amino sugar and nucleotide sugar metabolism"
XP_053952688.1	37	Reactome: R-HSA-2467813;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-9639288;Reactome: R-HSA-159236;Reactome: R-HSA-159230;Reactome: R-HSA-9648025;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-141444;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-168325;Reactome: R-HSA-168276;Reactome: R-HSA-2132295;Reactome: R-HSA-983170;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-6784531;Reactome: R-HSA-204005;Reactome: R-HSA-3371453;Reactome: R-HSA-168271	"Separation of Sister Chromatids";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"Amino acids regulate mTORC1";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP Dependant Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"Viral Messenger RNA Synthesis";"NS1 Mediated Effects on Host Pathways";"MHC class II antigen presentation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"tRNA processing in the nucleus";"COPII-mediated vesicle transport";"Regulation of HSF1-mediated heat shock response";"Transport of Ribonucleoproteins into the Host Nucleus"
XP_053961997.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_053951141.1	13	KEGG: 00720+4.2.1.2;MetaCyc: PWY-5690;MetaCyc: PWY-5392;MetaCyc: PWY-6969;KEGG: 00620+4.2.1.2;MetaCyc: PWY-561;MetaCyc: PWY-8086;MetaCyc: PWY-5913;KEGG: 00020+4.2.1.2;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-7254;MetaCyc: PWY-7384	"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate metabolism";"Superpathway of glyoxylate cycle and fatty acid degradation";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Anaerobic energy metabolism (invertebrates, mitochondrial)"
XP_053963622.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053953192.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053952231.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_053946963.1	6	KEGG: 05235+3.1.3.16;Reactome: R-HSA-8939211;KEGG: 04660+3.1.3.16;Reactome: R-HSA-5693565;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5675221	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"ESR-mediated signaling";"T cell receptor signaling pathway";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Th1 and Th2 cell differentiation";"Negative regulation of MAPK pathway"
XP_053967400.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_053954601.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942	"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition"
XP_053953408.1	4	Reactome: R-HSA-156581;Reactome: R-HSA-6782315;Reactome: R-HSA-72764;Reactome: R-HSA-6790901	"Methylation";"tRNA modification in the nucleus and cytosol";"Eukaryotic Translation Termination";"rRNA modification in the nucleus and cytosol"
XP_053960573.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053951120.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053968226.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053947537.1	30	Reactome: R-HSA-2871837;Reactome: R-HSA-2122947;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-69231;Reactome: R-HSA-5610783;Reactome: R-HSA-5684264;Reactome: R-HSA-2644606;Reactome: R-HSA-180534;Reactome: R-HSA-2894862;Reactome: R-HSA-2644607;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-2565942;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-174113;Reactome: R-HSA-9604323;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-8854050;Reactome: R-HSA-400253;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-1170546;Reactome: R-HSA-917937	"FCERI mediated NF-kB activation";"NOTCH1 Intracellular Domain Regulates Transcription";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Cyclin D associated events in G1";"Degradation of GLI2 by the proteasome";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Vpu mediated degradation of CD4";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"Regulation of PLK1 Activity at G2/M Transition";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"Negative regulation of NOTCH4 signaling";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Circadian Clock";"Neddylation";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"Prolactin receptor signaling";"Iron uptake and transport"
XP_053955683.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_053969524.1	19	Reactome: R-HSA-380320;MetaCyc: PWY-7184;MetaCyc: PWY-7187;KEGG: 00230+2.7.4.6;MetaCyc: PWY-6545;MetaCyc: PWY-7197;MetaCyc: PWY-7226;MetaCyc: PWY-7205;Reactome: R-HSA-380270;MetaCyc: PWY-7227;MetaCyc: PWY-7176;MetaCyc: PWY-7224;MetaCyc: PWY-7210;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7220;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7221;MetaCyc: PWY-7222;MetaCyc: PWY-7198	"Recruitment of NuMA to mitotic centrosomes";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotide phosphorylation";"Guanosine deoxyribonucleotides de novo biosynthesis I";"CMP phosphorylation";"Recruitment of mitotic centrosome proteins and complexes";"Adenosine deoxyribonucleotides de novo biosynthesis";"UTP and CTP de novo biosynthesis";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV"
XP_053966065.1	6	Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884	"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I"
XP_053948909.1	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
XP_053965387.1	3	Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053958720.1	11	Reactome: R-HSA-73776;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-3214847;Reactome: R-HSA-6804756;Reactome: R-HSA-5689880	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"HATs acetylate histones";"Regulation of TP53 Activity through Phosphorylation";"Ub-specific processing proteases"
XP_053947596.1	5	KEGG: 00190+7.1.1.8;MetaCyc: PWY-7279;MetaCyc: PWY-6692;MetaCyc: PWY-3781;MetaCyc: PWY-7082	"Oxidative phosphorylation";"Aerobic respiration II (cytochrome c) (yeast)";"Fe(II) oxidation";"Aerobic respiration I (cytochrome c)";"Ammonia oxidation IV (autotrophic ammonia oxidizers)"
XP_053968451.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_053960657.1	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
XP_053958577.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053964442.1	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
XP_053954759.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_053951128.1	16	Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_053952962.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053964449.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053954752.1	3	KEGG: 00230+2.7.1.20;Reactome: R-HSA-74217;MetaCyc: PWY-6619	"Purine metabolism";"Purine salvage";"Adenine and adenosine salvage VI"
XP_053957184.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053969933.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053964097.1	4	Reactome: R-HSA-418594;Reactome: R-HSA-201681;Reactome: R-HSA-5689880;Reactome: R-HSA-4641257	"G alpha (i) signalling events";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"Degradation of AXIN"
XP_053947069.1	7	Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-76066;Reactome: R-HSA-73780	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation"
XP_053952931.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053960918.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_053956502.1	4	Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Laminin interactions";"MET activates PTK2 signaling"
XP_053959330.1	10	Reactome: R-HSA-3299685;Reactome: R-HSA-111463;Reactome: R-HSA-9627069;Reactome: R-HSA-611105;Reactome: R-HSA-111457;Reactome: R-HSA-111464;Reactome: R-HSA-111459;Reactome: R-HSA-5628897;Reactome: R-HSA-111458;Reactome: R-HSA-2151201	"Detoxification of Reactive Oxygen Species";"SMAC (DIABLO) binds to IAPs";"Regulation of the apoptosome activity";"Respiratory electron transport";"Release of apoptotic factors from the mitochondria";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Activation of caspases through apoptosome-mediated cleavage";"TP53 Regulates Metabolic Genes";"Formation of apoptosome";"Transcriptional activation of mitochondrial biogenesis"
XP_053945508.1	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis"
XP_053956543.1	7	Reactome: R-HSA-1989781;KEGG: 00071+1.3.8.7;Reactome: R-HSA-77288;MetaCyc: PWY-7094;Reactome: R-HSA-77346;Reactome: R-HSA-77348;KEGG: 00280+1.3.8.7	"PPARA activates gene expression";"Fatty acid degradation";"mitochondrial fatty acid beta-oxidation of unsaturated fatty acids";"Fatty acid salvage";"Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA";"Beta oxidation of octanoyl-CoA to hexanoyl-CoA";"Valine, leucine and isoleucine degradation"
XP_053955852.1	3	KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Triglyceride biosynthesis";"Glycerol degradation I"
XP_053966309.1	10	Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-2197563;Reactome: R-HSA-2894862;Reactome: R-HSA-9013695;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-9013508;Reactome: R-HSA-2122947;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"NOTCH2 intracellular domain regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
XP_053946658.1	2	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_053966343.1	2	KEGG: 04070+2.7.11.13;Reactome: R-HSA-5625740	"Phosphatidylinositol signaling system";"RHO GTPases activate PKNs"
XP_053948101.1	1	Reactome: R-HSA-3214815	"HDACs deacetylate histones"
XP_053967286.1	8	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Thermogenesis";"Activation of RAC1";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_053958517.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053957147.1	1	Reactome: R-HSA-977347	"Serine biosynthesis"
XP_053956647.1	7	Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-76066	"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_053950046.1	4	Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2122947	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_053969530.1	12	MetaCyc: PWY-1187;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6309;MetaCyc: PWY-6842;MetaCyc: PWY-6936;MetaCyc: PWY-2821;KEGG: 00450+4.4.1.13;MetaCyc: PWY-7901;KEGG: 00380+2.6.1.7;MetaCyc: PWY-801;MetaCyc: PWY-601;Reactome: R-HSA-71240	"Glucosinolate biosynthesis from homomethionine";"Cysteine and methionine metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glutathione-mediated detoxification II";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from phenylalanine";"Selenocompound metabolism";"Glucosinolate biosynthesis from tyrosine";"Tryptophan metabolism";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from tryptophan";"Tryptophan catabolism"
XP_053955659.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053949886.1	6	KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807;MetaCyc: PWY-7761;KEGG: 00760+6.3.5.1;MetaCyc: PWY-5381;MetaCyc: PWY-5653	"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde"
XP_053954783.1	3	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394;Reactome: R-HSA-3214847	"UCH proteinases";"DNA Damage Recognition in GG-NER";"HATs acetylate histones"
XP_053957788.1	18	MetaCyc: PWY-5913;MetaCyc: PWY-7115;MetaCyc: PWY-6728;KEGG: 00020+1.1.1.37;MetaCyc: PWY-561;Reactome: R-HSA-70263;MetaCyc: PWY-8086;KEGG: 00620+1.1.1.37;KEGG: 00710+1.1.1.37;KEGG: 00270+1.1.1.37;MetaCyc: PWY-6969;MetaCyc: PWY-5392;KEGG: 00630+1.1.1.37;MetaCyc: PWY-7383;MetaCyc: PWY-5690;KEGG: 00720+1.1.1.37;KEGG: 00680+1.1.1.37;MetaCyc: PWY-1622	"Partial TCA cycle (obligate autotrophs)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Methylaspartate cycle";"Citrate cycle (TCA cycle)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Gluconeogenesis";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Carbon fixation in photosynthetic organisms";"Cysteine and methionine metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"Glyoxylate and dicarboxylate metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"TCA cycle II (plants and fungi)";"Carbon fixation pathways in prokaryotes";"Methane metabolism";"Formaldehyde assimilation I (serine pathway)"
XP_053950382.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053963000.1	7	Reactome: R-HSA-1855204;Reactome: R-HSA-8856828;Reactome: R-HSA-1660499;Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368	"Synthesis of IP3 and IP4 in the cytosol";"Clathrin-mediated endocytosis";"Synthesis of PIPs at the plasma membrane";"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation"
XP_053951242.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053951724.1	3	Reactome: R-HSA-6784531;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470	"tRNA processing in the nucleus";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion"
XP_053951203.1	18	Reactome: R-HSA-1482788;Reactome: R-HSA-1482925;MetaCyc: PWY-7417;MetaCyc: PWY-8053;Reactome: R-HSA-1482801;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482839;Reactome: R-HSA-1483166;KEGG: 00592+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416	"Acyl chain remodelling of PC";"Acyl chain remodelling of PG";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PS";"Glycerophospholipid metabolism";"Acyl chain remodelling of PE";"Synthesis of PA";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Linoleic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)"
XP_053952139.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053948540.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053953986.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_053952880.1	3	Reactome: R-HSA-73843;KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"5-Phosphoribose 1-diphosphate biosynthesis";"Pentose phosphate pathway";"Purine metabolism"
XP_053946257.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_053952944.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_053945724.1	14	Reactome: R-HSA-75876;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7601;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-5080	"Synthesis of very long-chain fatty acyl-CoAs";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I"
XP_053945249.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-6796648	"Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes"
XP_053955569.1	7	Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-6798695;Reactome: R-HSA-445095;Reactome: R-HSA-373753;Reactome: R-HSA-264870;Reactome: R-HSA-6807878	"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"Neutrophil degranulation";"Interaction between L1 and Ankyrins";"Nephrin family interactions";"Caspase-mediated cleavage of cytoskeletal proteins";"COPI-mediated anterograde transport"
XP_053960978.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053956465.1	6	Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation"
XP_053965785.1	3	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_053946917.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053946133.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053950373.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053950432.1	13	KEGG: 00511+3.2.1.52;MetaCyc: PWY-7883;Reactome: R-HSA-1660662;KEGG: 00603+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;KEGG: 00520+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;Reactome: R-HSA-2160916	"Other glycan degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"CS/DS degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Hyaluronan uptake and degradation"
XP_053950925.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053967291.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053955081.1	5	Reactome: R-HSA-8943724;Reactome: R-HSA-3214815;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-6804758	"Regulation of PTEN gene transcription";"HDACs deacetylate histones";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation"
XP_053946904.1	6	KEGG: 00680+5.4.2.11;MetaCyc: PWY-8004;KEGG: 00260+5.4.2.11;MetaCyc: PWY-5484;MetaCyc: PWY-1622;KEGG: 00010+5.4.2.11	"Methane metabolism";"Entner-Doudoroff pathway I";"Glycine, serine and threonine metabolism";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation I (serine pathway)";"Glycolysis / Gluconeogenesis"
XP_053949891.1	6	MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1;MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+6.3.1.5	"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism"
XP_053969538.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053958504.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053958011.1	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
XP_053950776.1	12	Reactome: R-HSA-5673001;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-399719;Reactome: R-HSA-9620244;KEGG: 00230+2.7.4.8;Reactome: R-HSA-447038;Reactome: R-HSA-451308;MetaCyc: PWY-7221;Reactome: R-HSA-438066;Reactome: R-HSA-8849932;Reactome: R-HSA-9609736	"RAF/MAP kinase cascade";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Trafficking of AMPA receptors";"Long-term potentiation";"Purine metabolism";"NrCAM interactions";"Activation of Ca-permeable Kainate Receptor";"Guanosine ribonucleotides de novo biosynthesis";"Unblocking of NMDA receptors, glutamate binding and activation";"Synaptic adhesion-like molecules";"Assembly and cell surface presentation of NMDA receptors"
XP_053946650.1	3	Reactome: R-HSA-2468052;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257	"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion"
XP_053961115.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053946217.1	1	Reactome: R-HSA-2028269	"Signaling by Hippo"
XP_053961300.1	13	Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-6969;MetaCyc: PWY-5913;MetaCyc: PWY-5392;MetaCyc: PWY-7384;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5690;KEGG: 00660+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5538;MetaCyc: PWY-5537;KEGG: 00020+6.2.1.5	"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)";"Reductive TCA cycle II";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"C5-Branched dibasic acid metabolism";"Propanoate metabolism";"Pyruvate fermentation to acetate VI";"Pyruvate fermentation to acetate V";"Citrate cycle (TCA cycle)"
XP_053952722.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_053956948.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053964443.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_053953440.1	57	Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-69481;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-69601;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-5687128;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-6798695;Reactome: R-HSA-450408;Reactome: R-HSA-180534;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-4608870;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-4641257;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5668541;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-349425;Reactome: R-HSA-5362768;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5676590;Reactome: R-HSA-202424	"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"G2/M Checkpoints";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"MAPK6/MAPK4 signaling";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Neutrophil degranulation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vpu mediated degradation of CD4";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Asymmetric localization of PCP proteins";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"Degradation of DVL";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"Degradation of AXIN";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"TNFR2 non-canonical NF-kB pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Autodegradation of the E3 ubiquitin ligase COP1";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling"
XP_053958701.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling"
XP_053949856.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_053952963.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053969961.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_053950352.1	18	Reactome: R-HSA-1482801;Reactome: R-HSA-1482839;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482925;Reactome: R-HSA-1482788;MetaCyc: PWY-8053;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7783;Reactome: R-HSA-1482922;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.4	"Acyl chain remodelling of PS";"Acyl chain remodelling of PE";"Synthesis of PA";"Glycerophospholipid metabolism";"Acyl chain remodelling of PG";"Acyl chain remodelling of PC";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Plasmalogen degradation";"Acyl chain remodelling of PI";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism"
XP_053963750.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_053955682.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_053955667.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053953421.1	7	KEGG: 00521+3.1.3.25;MetaCyc: PWY-2301;KEGG: 04070+3.1.3.25;KEGG: 00562+3.1.3.25;MetaCyc: PWY-6363;MetaCyc: PWY-4702;Reactome: R-HSA-1855183	"Streptomycin biosynthesis";"Myo-inositol biosynthesis";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Phytate degradation I";"Synthesis of IP2, IP, and Ins in the cytosol"
XP_053949865.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053948942.1	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
XP_053962360.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053964866.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_053967916.1	7	KEGG: 00983+2.7.4.14;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;MetaCyc: PWY-7176;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00240+2.7.4.14	"Drug metabolism - other enzymes";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"UTP and CTP de novo biosynthesis";"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Pyrimidine metabolism"
XP_053955689.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053967327.1	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
XP_053965471.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_053954227.1	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
XP_053955853.1	3	Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Triglyceride biosynthesis";"Glycerolipid metabolism";"Glycerol degradation I"
XP_053965755.1	4	Reactome: R-HSA-4755583;KEGG: 00510+2.7.1.108;Reactome: R-HSA-446199;MetaCyc: PWY-6129	"Defective DOLK causes DOLK-CDG (CDG-1m)";"N-Glycan biosynthesis";"Synthesis of Dolichyl-phosphate";"Dolichol and dolichyl phosphate biosynthesis"
XP_053957710.1	3	Reactome: R-HSA-3899300;Reactome: R-HSA-9609690;Reactome: R-HSA-6804757	"SUMOylation of transcription cofactors";"HCMV Early Events";"Regulation of TP53 Degradation"
XP_053951027.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053951548.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-71403	"Mitochondrial protein import";"Citric acid cycle (TCA cycle)"
XP_053969932.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053953956.1	4	KEGG: 00860+2.5.1.61;Reactome: R-HSA-189451;MetaCyc: PWY-5188;MetaCyc: PWY-5189	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Tetrapyrrole biosynthesis II (from glycine)"
XP_053969939.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053965766.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053958081.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_053945540.1	3	Reactome: R-HSA-8963684;Reactome: R-HSA-204174;Reactome: R-HSA-156590	"Tyrosine catabolism";"Regulation of pyruvate dehydrogenase (PDH) complex";"Glutathione conjugation"
XP_053965377.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053954713.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053964815.1	2	Reactome: R-HSA-9033500;Reactome: R-HSA-9033241	"TYSND1 cleaves peroxisomal proteins";"Peroxisomal protein import"
XP_053950319.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_053949816.1	7	Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-156711;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-1362300;Reactome: R-HSA-69202	"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin E associated events during G1/S transition"
XP_053970083.1	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
XP_053962106.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_053955260.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_053954834.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053956814.1	3	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109	"Glycerol degradation I";"Glycerolipid metabolism";"Triglyceride biosynthesis"
XP_053945521.1	7	KEGG: 00010+1.2.4.1;KEGG: 00020+1.2.4.1;Reactome: R-HSA-5362517;Reactome: R-HSA-389661;Reactome: R-HSA-204174;Reactome: R-HSA-70268;KEGG: 00620+1.2.4.1	"Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)";"Signaling by Retinoic Acid";"Glyoxylate metabolism and glycine degradation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Pyruvate metabolism"
XP_053948242.1	2	Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_053958569.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053947861.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053960579.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053949676.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053969018.1	16	Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-2559585;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-9029569	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"Oncogene Induced Senescence";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_053954316.1	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
XP_053970168.1	3	MetaCyc: PWY-7942;KEGG: 00480+4.3.2.7;Reactome: R-HSA-174403	"5-oxo-L-proline metabolism";"Glutathione metabolism";"Glutathione synthesis and recycling"
XP_053954641.1	3	MetaCyc: PWY-2161B;KEGG: 00790+3.4.19.9;Reactome: R-HSA-6798695	"Glutamate removal from folates";"Folate biosynthesis";"Neutrophil degranulation"
XP_053958652.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_053955734.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053968005.1	7	KEGG: 00600+2.4.1.80;MetaCyc: PWY-7838;Reactome: R-HSA-1660662;MetaCyc: PWY-7839;MetaCyc: PWY-7836;MetaCyc: PWY-5129;MetaCyc: PWY-7841	"Sphingolipid metabolism";"Globo-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism";"Lacto-series glycosphingolipids biosynthesis";"Ganglio-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)";"Neolacto-series glycosphingolipids biosynthesis"
XP_053953265.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection"
XP_053945101.1	3	Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355	"Nitric oxide stimulates guanylate cyclase";"Purine metabolism";"Smooth Muscle Contraction"
XP_053947077.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053958096.1	1	Reactome: R-HSA-140342	"Apoptosis induced DNA fragmentation"
XP_053970224.1	5	Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-73762	"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation"
XP_053963623.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053946680.1	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
XP_053953256.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053964190.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053948169.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_053955121.1	8	Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-8943724;Reactome: R-HSA-6798695;Reactome: R-HSA-380972;Reactome: R-HSA-9639288	"mTOR signalling";"Macroautophagy";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"Regulation of PTEN gene transcription";"Neutrophil degranulation";"Energy dependent regulation of mTOR by LKB1-AMPK";"Amino acids regulate mTORC1"
XP_053958084.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053957038.1	6	Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-429958;Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_053963030.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053947335.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
XP_053960927.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257	"RHO GTPases Activate Formins";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion"
XP_053954579.1	3	Reactome: R-HSA-1650814;KEGG: 00330+1.14.11.2;MetaCyc: PWY-7894	"Collagen biosynthesis and modifying enzymes";"Arginine and proline metabolism";"Procollagen hydroxylation and glycosylation"
XP_053963252.1	3	Reactome: R-HSA-2980766;Reactome: R-HSA-2995383;Reactome: R-HSA-4419969	"Nuclear Envelope Breakdown";"Initiation of Nuclear Envelope Reformation";"Depolymerisation of the Nuclear Lamina"
XP_053968665.1	4	Reactome: R-HSA-982772;Reactome: R-HSA-983231;Reactome: R-HSA-2586552;Reactome: R-HSA-1170546	"Growth hormone receptor signaling";"Factors involved in megakaryocyte development and platelet production";"Signaling by Leptin";"Prolactin receptor signaling"
XP_053952529.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.5	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053963588.1	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
XP_053951117.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053961338.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_053963259.1	6	KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;MetaCyc: PWY-7900;Reactome: R-HSA-189085;KEGG: 00500+2.4.1.18;MetaCyc: PWY-622	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Starch biosynthesis"
XP_053959236.1	22	Reactome: R-HSA-2500257;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-2467813;Reactome: R-HSA-5467348;Reactome: R-HSA-68877;Reactome: R-HSA-5358751;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-6811558;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5663220	"Resolution of Sister Chromatid Cohesion";"Beta-catenin phosphorylation cascade";"RAF activation";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"Truncations of AMER1 destabilize the destruction complex";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins"
XP_053946234.1	2	Reactome: R-HSA-5689896;Reactome: R-HSA-195253	"Ovarian tumor domain proteases";"Degradation of beta-catenin by the destruction complex"
XP_053969738.1	4	Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_053960834.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_053965035.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053958704.1	5	Reactome: R-HSA-6798695;KEGG: 00230+3.6.1.6;KEGG: 00240+3.6.1.6;MetaCyc: PWY-7210;MetaCyc: PWY-7185	"Neutrophil degranulation";"Purine metabolism";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"UTP and CTP dephosphorylation I"
XP_053966339.1	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
XP_053948131.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053969964.1	4	MetaCyc: PWY-7887;Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+2.8.1.12	"Protein SAMPylation and SAMP-mediated thiolation";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis"
XP_053957912.1	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
XP_053946827.1	4	Reactome: R-HSA-1237112;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361	"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_053951104.1	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
XP_053945933.1	6	MetaCyc: PWY-7234;MetaCyc: PWY-6124;MetaCyc: PWY-6123;KEGG: 00230+3.5.4.10+2.1.2.3;Reactome: R-HSA-73817;KEGG: 00670+2.1.2.3	"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"One carbon pool by folate"
XP_053954583.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_053963580.1	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
XP_053964495.1	17	KEGG: 00254+6.4.1.2;KEGG: 00640+6.4.1.2;MetaCyc: PWY-5789;Reactome: R-HSA-200425;MetaCyc: PWY-5743;MetaCyc: PWY-6722;KEGG: 00620+6.4.1.2;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6679;Reactome: R-HSA-2426168;MetaCyc: PWY-5966-1;MetaCyc: PWY-5744;KEGG: 00720+6.4.1.2;Reactome: R-HSA-3371599;MetaCyc: PWY-4381;Reactome: R-HSA-163765;Reactome: R-HSA-196780	"Aflatoxin biosynthesis";"Propanoate metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Carnitine metabolism";"3-hydroxypropanoate cycle";"Candicidin biosynthesis";"Pyruvate metabolism";"Fatty acid biosynthesis";"Jadomycin biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Glyoxylate assimilation";"Carbon fixation pathways in prokaryotes";"Defective HLCS causes multiple carboxylase deficiency";"Fatty acid biosynthesis initiation (bacteria and plants)";"ChREBP activates metabolic gene expression";"Biotin transport and metabolism"
XP_053965686.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_053954869.1	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
XP_053957588.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053958534.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_053966645.1	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
XP_053945104.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053969730.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053955762.1	6	MetaCyc: PWY-7290;Reactome: R-HSA-913709;KEGG: 00512+2.4.1.122;MetaCyc: PWY-7433;KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632	"Escherichia coli serotype O86 O-antigen biosynthesis";"O-linked glycosylation of mucins";"Mucin type O-glycan biosynthesis";"Mucin core 1 and core 2 O-glycosylation";"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)"
XP_053966482.1	5	Reactome: R-HSA-5674400;Reactome: R-HSA-3371571;Reactome: R-HSA-165159;Reactome: R-HSA-198323;Reactome: R-HSA-166208	"Constitutive Signaling by AKT1 E17K in Cancer";"HSF1-dependent transactivation";"mTOR signalling";"AKT phosphorylates targets in the cytosol";"mTORC1-mediated signalling"
XP_053966467.1	7	Reactome: R-HSA-3000178;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;Reactome: R-HSA-5083633;Reactome: R-HSA-9010553;Reactome: R-HSA-3000171;Reactome: R-HSA-5083628	"ECM proteoglycans";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Regulation of expression of SLITs and ROBOs";"Non-integrin membrane-ECM interactions";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3"
XP_053945524.1	1	Reactome: R-HSA-480985	"Synthesis of dolichyl-phosphate-glucose"
XP_053949362.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053969128.1	6	Reactome: R-HSA-4086398;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-4411364;Reactome: R-HSA-3769402;Reactome: R-HSA-8951430	"Ca2+ pathway";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex";"RUNX3 regulates WNT signaling"
XP_053950198.1	10	Reactome: R-HSA-6804756;Reactome: R-HSA-8948751;Reactome: R-HSA-1483191;Reactome: R-HSA-6798695;Reactome: R-HSA-2514853;Reactome: R-HSA-201688;Reactome: R-HSA-8934903;Reactome: R-HSA-445144;Reactome: R-HSA-6814122;Reactome: R-HSA-8939243	"Regulation of TP53 Activity through Phosphorylation";"Regulation of PTEN stability and activity";"Synthesis of PC";"Neutrophil degranulation";"Condensation of Prometaphase Chromosomes";"WNT mediated activation of DVL";"Receptor Mediated Mitophagy";"Signal transduction by L1";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_053948721.1	2	Reactome: R-HSA-2032785;Reactome: R-HSA-8951671	"YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription"
XP_053960753.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_053954831.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_053951524.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_053948740.1	4	Reactome: R-HSA-2408522;Reactome: R-HSA-379716;Reactome: R-HSA-379726;KEGG: 00970+6.1.1.6	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053950443.1	13	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-3928662;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-416482;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3928663;KEGG: 05163+2.7.11.1;Reactome: R-HSA-416572;Reactome: R-HSA-5627117;Reactome: R-HSA-4420097	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"EPHB-mediated forward signaling";"mTOR signaling pathway";"Relaxin signaling pathway";"G alpha (12/13) signalling events";"Human immunodeficiency virus 1 infection";"Thermogenesis";"EPHA-mediated growth cone collapse";"Human cytomegalovirus infection";"Sema4D induced cell migration and growth-cone collapse";"RHO GTPases Activate ROCKs";"VEGFA-VEGFR2 Pathway"
XP_053964461.1	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
XP_053961450.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_053957660.1	14	Reactome: R-HSA-9634638;Reactome: R-HSA-9648025;Reactome: R-HSA-3769402;Reactome: R-HSA-69273;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-165054;Reactome: R-HSA-5687128;Reactome: R-HSA-450520;Reactome: R-HSA-5663220;Reactome: R-HSA-2173788;Reactome: R-HSA-141444;Reactome: R-HSA-168333	"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"EML4 and NUDC in mitotic spindle formation";"Deactivation of the beta-catenin transactivating complex";"Cyclin A/B1/B2 associated events during G2/M transition";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Rev-mediated nuclear export of HIV RNA";"MAPK6/MAPK4 signaling";"HuR (ELAVL1) binds and stabilizes mRNA";"RHO GTPases Activate Formins";"Downregulation of TGF-beta receptor signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"NEP/NS2 Interacts with the Cellular Export Machinery"
XP_053962975.1	17	KEGG: 04658+3.1.3.16;Reactome: R-HSA-113418;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-167243;Reactome: R-HSA-167152;KEGG: 04660+3.1.3.16;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167242;Reactome: R-HSA-167238;KEGG: 05235+3.1.3.16;Reactome: R-HSA-167246	"Th1 and Th2 cell differentiation";"Formation of the Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"T cell receptor signaling pathway";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Tat-mediated elongation of the HIV-1 transcript"
XP_053959321.1	2	Reactome: R-HSA-456926;Reactome: R-HSA-416482	"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (12/13) signalling events"
XP_053948524.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053951740.1	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.20	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_053958762.1	4	Reactome: R-HSA-5663213;Reactome: R-HSA-8856828;Reactome: R-HSA-3928662;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation"
XP_053945078.1	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
XP_053945740.1	4	Reactome: R-HSA-8943724;Reactome: R-HSA-3214815;Reactome: R-HSA-73762;Reactome: R-HSA-427389	"Regulation of PTEN gene transcription";"HDACs deacetylate histones";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"
XP_053957989.1	25	Reactome: R-HSA-190840;Reactome: R-HSA-437239;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-1445148;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-9619483;Reactome: R-HSA-5626467;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-380320;Reactome: R-HSA-983189;Reactome: R-HSA-5663220;Reactome: R-HSA-6807878;Reactome: R-HSA-380270;Reactome: R-HSA-8852276;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-190861;Reactome: R-HSA-3371497;Reactome: R-HSA-68877	"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Recycling pathway of L1";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Activation of AMPK downstream of NMDARs";"RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Cilium Assembly";"Recruitment of NuMA to mitotic centrosomes";"Kinesins";"RHO GTPases Activate Formins";"COPI-mediated anterograde transport";"Recruitment of mitotic centrosome proteins and complexes";"The role of GTSE1 in G2/M progression after G2 checkpoint";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"Separation of Sister Chromatids";"Gap junction assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Mitotic Prometaphase"
XP_053956533.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_053958148.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053952920.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_053964776.1	4	Reactome: R-HSA-5696394;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823	"DNA Damage Recognition in GG-NER";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex"
XP_053947415.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053965341.1	4	MetaCyc: PWY-7437;Reactome: R-HSA-3214847;Reactome: R-HSA-5689603;KEGG: 00514+2.4.1.255	"Protein O-[N-acetyl]-glucosylation";"HATs acetylate histones";"UCH proteinases";"Other types of O-glycan biosynthesis"
XP_053960436.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053956079.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053963973.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_053965515.1	1	Reactome: R-HSA-198933	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
XP_053949317.1	1	Reactome: R-HSA-977443	"GABA receptor activation"
XP_053963267.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053954677.1	17	MetaCyc: PWY-7179-1;MetaCyc: PWY-5695;Reactome: R-HSA-74259;KEGG: 00760+2.4.2.1;MetaCyc: PWY-7179;MetaCyc: PWY-4202;MetaCyc: PWY-6608;KEGG: 00240+2.4.2.1;MetaCyc: PWY-5532;MetaCyc: PWY-6609;MetaCyc: PWY-6620;MetaCyc: PWY-6644;KEGG: 00230+2.4.2.1;Reactome: R-HSA-6798695;Reactome: R-HSA-74217;MetaCyc: PWY-6611;MetaCyc: PWY-6627	"Purine deoxyribonucleosides degradation II";"Inosine 5'-phosphate degradation";"Purine catabolism";"Nicotinate and nicotinamide metabolism";"Purine deoxyribonucleosides degradation I";"Arsenate detoxification I (mammalian)";"Guanosine nucleotides degradation III";"Pyrimidine metabolism";"Nucleoside and nucleotide degradation (archaea)";"Adenine and adenosine salvage III";"Guanine and guanosine salvage";"Fluoroacetate and fluorothreonine biosynthesis";"Purine metabolism";"Neutrophil degranulation";"Purine salvage";"Adenine and adenosine salvage V";"Salinosporamide A biosynthesis"
XP_053957550.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_053948104.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_053952228.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling"
XP_053957973.1	3	KEGG: 00860+2.5.1.141;Reactome: R-HSA-189451;MetaCyc: PWY-7856	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Heme a biosynthesis"
XP_053957325.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053947466.1	6	Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107	"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_053956083.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053965665.1	6	Reactome: R-HSA-8948216;Reactome: R-HSA-8874081;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814;Reactome: R-HSA-2022090;Reactome: R-HSA-3000171	"Collagen chain trimerization";"MET activates PTK2 signaling";"Collagen degradation";"Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures";"Non-integrin membrane-ECM interactions"
XP_053947028.1	6	Reactome: R-HSA-6803204;Reactome: R-HSA-6803211;Reactome: R-HSA-139915;Reactome: R-HSA-6803205;Reactome: R-HSA-6803207;Reactome: R-HSA-6804759	"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"TP53 Regulates Transcription of Death Receptors and Ligands";"Activation of PUMA and translocation to mitochondria";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Regulation of TP53 Activity through Association with Co-factors"
XP_053953378.1	14	Reactome: R-HSA-1482788;MetaCyc: PWY-8053;MetaCyc: PWY-7417;Reactome: R-HSA-975634;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783	"Acyl chain remodelling of PC";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Retinoid metabolism and transport";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Plasmalogen degradation"
XP_053952220.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171	"MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions"
XP_053957289.1	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
XP_053957558.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053955223.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053968035.1	7	KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053957282.1	8	MetaCyc: PWY-7179;MetaCyc: PWY-7179-1;Reactome: R-HSA-5683826;MetaCyc: PWY-6609;MetaCyc: PWY-6611;KEGG: 00230+3.5.4.4;Reactome: R-HSA-6798695;Reactome: R-HSA-74217	"Purine deoxyribonucleosides degradation I";"Purine deoxyribonucleosides degradation II";"Surfactant metabolism";"Adenine and adenosine salvage III";"Adenine and adenosine salvage V";"Purine metabolism";"Neutrophil degranulation";"Purine salvage"
XP_053947399.1	4	MetaCyc: PWY-7119;MetaCyc: PWY-6483;Reactome: R-HSA-1660662;KEGG: 00600+3.5.1.23	"Ceramide and sphingolipid recycling and degradation (yeast)";"Ceramide degradation (generic)";"Glycosphingolipid metabolism";"Sphingolipid metabolism"
XP_053945162.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_053945187.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053965328.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053947392.1	4	KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-7119;MetaCyc: PWY-6483	"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)";"Ceramide degradation (generic)"
XP_053963273.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_053946901.1	6	KEGG: 00010+5.4.2.11;MetaCyc: PWY-5484;MetaCyc: PWY-1622;KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;KEGG: 00680+5.4.2.11	"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation I (serine pathway)";"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Methane metabolism"
XP_053949894.1	6	MetaCyc: PWY-7761;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807;MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1	"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism"
XP_053963660.1	3	Reactome: R-HSA-212676;Reactome: R-HSA-6794361;Reactome: R-HSA-9609736	"Dopamine Neurotransmitter Release Cycle";"Neurexins and neuroligins";"Assembly and cell surface presentation of NMDA receptors"
XP_053965566.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8949613	"Mitochondrial protein import";"Cristae formation"
XP_053968691.1	4	Reactome: R-HSA-1170546;Reactome: R-HSA-2586552;Reactome: R-HSA-983231;Reactome: R-HSA-982772	"Prolactin receptor signaling";"Signaling by Leptin";"Factors involved in megakaryocyte development and platelet production";"Growth hormone receptor signaling"
XP_053951169.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053963967.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_053959348.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_053964046.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_053952928.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_053954804.1	4	Reactome: R-HSA-400511;Reactome: R-HSA-422085;Reactome: R-HSA-381771;Reactome: R-HSA-1799339	"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"SRP-dependent cotranslational protein targeting to membrane"
XP_053963989.1	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
XP_053967294.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053951162.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_053957510.1	14	KEGG: 00564+2.3.1.51;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5667;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-5981;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51	"Glycerophospholipid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Plasmalogen biosynthesis";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism"
XP_053949045.1	2	Reactome: R-HSA-6803157;Reactome: R-HSA-6798695	"Antimicrobial peptides";"Neutrophil degranulation"
XP_053957993.1	11	Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-3214847;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-5689880	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HATs acetylate histones";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"Ub-specific processing proteases"
XP_053965079.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053966923.1	2	Reactome: R-HSA-5619039;Reactome: R-HSA-426117	"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)";"Cation-coupled Chloride cotransporters"
XP_053962530.1	34	Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-180910;Reactome: R-HSA-9639288;Reactome: R-HSA-159230;Reactome: R-HSA-159236;Reactome: R-HSA-9648025;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-159231;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-168333;Reactome: R-HSA-141444;Reactome: R-HSA-168276;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214	"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Vpr-mediated nuclear import of PICs";"Amino acids regulate mTORC1";"Transport of the SLBP Dependant Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"NS1 Mediated Effects on Host Pathways";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins"
XP_053965837.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_053958489.1	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
XP_053948255.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_053948915.1	5	Reactome: R-HSA-5663213;Reactome: R-HSA-8856828;Reactome: R-HSA-3928662;Reactome: R-HSA-6798695;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling";"Neutrophil degranulation";"Regulation of actin dynamics for phagocytic cup formation"
XP_053952206.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling"
XP_053956320.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053947791.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_053947379.1	4	Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-983712	"Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Ion channel transport"
XP_053959132.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053961201.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_053967800.1	3	Reactome: R-HSA-6783984;KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"Glycine degradation";"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_053947433.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_053947372.1	4	MetaCyc: PWY-7382;KEGG: 00785+2.3.1.181;Reactome: R-HSA-389661;MetaCyc: PWY-6987	"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation III (Bacillus)"
XP_053945985.1	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_053959139.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_053950551.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_053953808.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053966534.1	9	MetaCyc: PWY-1042;Reactome: R-HSA-70263;KEGG: 00710+1.2.1.12;Reactome: R-HSA-70171;MetaCyc: PWY-5484;MetaCyc: PWY-7003;MetaCyc: PWY-6901;MetaCyc: PWY-8004;KEGG: 00010+1.2.1.12	"Glycolysis IV (plant cytosol)";"Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"Glycerol degradation to butanol";"Superpathway of glucose and xylose degradation";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis"
XP_053946418.1	15	Reactome: R-HSA-5467333;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-196299;Reactome: R-HSA-5358752;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-3769402;Reactome: R-HSA-5358747;Reactome: R-HSA-5689896;Reactome: R-HSA-111465;Reactome: R-HSA-5358749;Reactome: R-HSA-5467340;Reactome: R-HSA-5339716;Reactome: R-HSA-195253	"APC truncation mutants are not K63 polyubiquitinated";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"T41 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Deactivation of the beta-catenin transactivating complex";"S33 mutants of beta-catenin aren't phosphorylated";"Ovarian tumor domain proteases";"Apoptotic cleavage of cellular proteins";"S37 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"Misspliced GSK3beta mutants stabilize beta-catenin";"Degradation of beta-catenin by the destruction complex"
XP_053950639.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_053965881.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053951985.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053953022.1	1	Reactome: R-HSA-2514859	"Inactivation, recovery and regulation of the phototransduction cascade"
XP_053953029.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_053952324.1	7	Reactome: R-HSA-6784531;Reactome: R-HSA-203927;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-1655829;Reactome: R-HSA-5578749;Reactome: R-HSA-180746	"tRNA processing in the nucleus";"MicroRNA (miRNA) biogenesis";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein"
XP_053964849.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_053965306.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053954705.1	5	MetaCyc: PWY-7511;Reactome: R-HSA-201681;Reactome: R-HSA-5689880;Reactome: R-HSA-8948751;Reactome: R-HSA-4641257	"Protein ubiquitination";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"Regulation of PTEN stability and activity";"Degradation of AXIN"
XP_053962995.1	7	Reactome: R-HSA-8856828;Reactome: R-HSA-1855204;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1660499	"Clathrin-mediated endocytosis";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the plasma membrane"
XP_053966223.1	10	KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2206292;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-2024096;MetaCyc: PWY-6807;Reactome: R-HSA-6798695;Reactome: R-HSA-2160916	"Other glycan degradation";"Galactose metabolism";"Sphingolipid metabolism";"MPS VII - Sly syndrome";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"HS-GAG degradation";"Xyloglucan degradation II (exoglucanase)";"Neutrophil degranulation";"Hyaluronan uptake and degradation"
XP_053958339.1	7	KEGG: 00030+3.1.3.11;KEGG: 00680+3.1.3.11;KEGG: 00710+3.1.3.11;Reactome: R-HSA-70263;MetaCyc: PWY-5484;KEGG: 00051+3.1.3.11;KEGG: 00010+3.1.3.11	"Pentose phosphate pathway";"Methane metabolism";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis"
XP_053964664.1	12	Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-75955	"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation"
XP_053962080.1	6	MetaCyc: PWY-7900;KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;Reactome: R-HSA-189085;MetaCyc: PWY-622;KEGG: 00500+2.4.1.18	"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Digestion of dietary carbohydrate";"Starch biosynthesis";"Starch and sucrose metabolism"
XP_053956092.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053955395.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053952906.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_053948215.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_053966757.1	6	Reactome: R-HSA-456926;Reactome: R-HSA-399997;Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-434316;Reactome: R-HSA-416476	"Thrombin signalling through proteinase activated receptors (PARs)";"Acetylcholine regulates insulin secretion";"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G alpha (q) signalling events"
XP_053960846.1	5	Reactome: R-HSA-8876198;Reactome: R-HSA-6798695;Reactome: R-HSA-1445148;Reactome: R-HSA-8873719;Reactome: R-HSA-1660499	"RAB GEFs exchange GTP for GDP on RABs";"Neutrophil degranulation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RAB geranylgeranylation";"Synthesis of PIPs at the plasma membrane"
XP_053954990.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053945285.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_053968013.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport"
XP_053963993.1	13	MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-5122;MetaCyc: PWY-6383;MetaCyc: PWY-6859;MetaCyc: PWY-7721;MetaCyc: PWY-7709;MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-7182;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-5123	"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis";"Geranyl diphosphate biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"All-trans-farnesol biosynthesis";"Methyl phomopsenoate biosynthesis";"(3R)-linalool biosynthesis";"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"Linalool biosynthesis I";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis"
XP_053954085.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053956566.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053967398.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_053964393.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_053965896.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_053953390.1	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
XP_053950714.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053956474.1	9	Reactome: R-HSA-73776;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-6804756	"RNA Polymerase II Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation"
XP_053958805.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_053953648.1	1	KEGG: 04150+2.7.11.24	"mTOR signaling pathway"
XP_053968749.1	1	Reactome: R-HSA-74217	"Purine salvage"
XP_053968224.1	19	Reactome: R-HSA-3000497;Reactome: R-HSA-8957275;Reactome: R-HSA-8856828;Reactome: R-HSA-8964026;Reactome: R-HSA-8856825;Reactome: R-HSA-432142;Reactome: R-HSA-381426;Reactome: R-HSA-8964041;Reactome: R-HSA-3000471;Reactome: R-HSA-202733;Reactome: R-HSA-3000484;Reactome: R-HSA-975634;Reactome: R-HSA-8964038;Reactome: R-HSA-8963888;Reactome: R-HSA-8963901;Reactome: R-HSA-5686938;Reactome: R-HSA-8964046;Reactome: R-HSA-8866423;Reactome: R-HSA-3000480	"Scavenging by Class H Receptors";"Post-translational protein phosphorylation";"Clathrin-mediated endocytosis";"Chylomicron clearance";"Cargo recognition for clathrin-mediated endocytosis";"Platelet sensitization by LDL";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"LDL remodeling";"Scavenging by Class B Receptors";"Cell surface interactions at the vascular wall";"Scavenging by Class F Receptors";"Retinoid metabolism and transport";"LDL clearance";"Chylomicron assembly";"Chylomicron remodeling";"Regulation of TLR by endogenous ligand";"VLDL clearance";"VLDL assembly";"Scavenging by Class A Receptors"
XP_053958452.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053948329.1	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
XP_053948322.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_053963423.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_053959277.1	22	Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5673000;Reactome: R-HSA-196299;Reactome: R-HSA-2500257;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-5358747;Reactome: R-HSA-6811558;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-5358751;Reactome: R-HSA-68877;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-432142;Reactome: R-HSA-389513;Reactome: R-HSA-141444	"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"RAF activation";"Beta-catenin phosphorylation cascade";"Resolution of Sister Chromatid Cohesion";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"S33 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"S45 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_053959850.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053961234.1	4	Reactome: R-HSA-5250958;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361	"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Neurexins and neuroligins"
XP_053965851.1	4	Reactome: R-HSA-5696394;Reactome: R-HSA-532668;Reactome: R-HSA-3108214;Reactome: R-HSA-5696395	"DNA Damage Recognition in GG-NER";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"SUMOylation of DNA damage response and repair proteins";"Formation of Incision Complex in GG-NER"
XP_053945966.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_053962058.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_053949739.1	3	KEGG: 00790+2.8.1.9;MetaCyc: PWY-5963;Reactome: R-HSA-947581	"Folate biosynthesis";"Thio-molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
XP_053958395.1	42	Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-73772;Reactome: R-HSA-110331;Reactome: R-HSA-5693607;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-427413;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-2299718;Reactome: R-HSA-3214815;Reactome: R-HSA-3214858;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-427389;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-5334118;Reactome: R-HSA-171306;Reactome: R-HSA-1221632;Reactome: R-HSA-9018519;Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-912446	"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"RNA Polymerase I Promoter Escape";"Cleavage of the damaged purine";"Processing of DNA double-strand break ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"NoRC negatively regulates rRNA expression";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"Condensation of Prophase Chromosomes";"HDACs deacetylate histones";"RMTs methylate histone arginines";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"DNA methylation";"Packaging Of Telomere Ends";"Meiotic synapsis";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"Meiotic recombination"
XP_053962425.1	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
XP_053951966.1	7	Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-5693571;Reactome: R-HSA-3108214;Reactome: R-HSA-5693565;Reactome: R-HSA-69473;Reactome: R-HSA-5693607	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Nonhomologous End-Joining (NHEJ)";"SUMOylation of DNA damage response and repair proteins";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends"
XP_053953247.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_053965671.1	3	Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300	"SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors"
XP_053947756.1	4	MetaCyc: PWY-2781;Reactome: R-HSA-6787450;Reactome: R-HSA-6782315;KEGG: 00908+2.5.1.75	"Cis-zeatin biosynthesis";"tRNA modification in the mitochondrion";"tRNA modification in the nucleus and cytosol";"Zeatin biosynthesis"
XP_053960444.1	42	Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-110331;Reactome: R-HSA-5693607;Reactome: R-HSA-9609690;Reactome: R-HSA-110328;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-427413;Reactome: R-HSA-2299718;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-73728;Reactome: R-HSA-5250924;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-5334118;Reactome: R-HSA-9018519;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-606279;Reactome: R-HSA-2559580;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-212300;Reactome: R-HSA-912446	"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged purine";"Processing of DNA double-strand break ends";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"NoRC negatively regulates rRNA expression";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"RNA Polymerase I Promoter Opening";"B-WICH complex positively regulates rRNA expression";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Meiotic synapsis";"Packaging Of Telomere Ends";"DNA methylation";"Estrogen-dependent gene expression";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Deposition of new CENPA-containing nucleosomes at the centromere";"Oxidative Stress Induced Senescence";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PRC2 methylates histones and DNA";"Meiotic recombination"
XP_053965053.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-1799339	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane"
XP_053959858.1	4	Reactome: R-HSA-3371497;Reactome: R-HSA-3371568;Reactome: R-HSA-8939211;Reactome: R-HSA-9018519	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Attenuation phase";"ESR-mediated signaling";"Estrogen-dependent gene expression"
XP_053950754.1	3	Reactome: R-HSA-9029569;Reactome: R-HSA-1369062;Reactome: R-HSA-8964058	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"ABC transporters in lipid homeostasis";"HDL remodeling"
XP_053966731.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053964711.1	3	Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13;Reactome: R-HSA-418597	"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"G alpha (z) signalling events"
XP_053966007.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-3134975;Reactome: R-HSA-3249367;Reactome: R-HSA-1834941;Reactome: R-HSA-3270619	"Neutrophil degranulation";"Regulation of innate immune responses to cytosolic DNA";"STAT6-mediated induction of chemokines";"STING mediated induction of host immune responses";"IRF3-mediated induction of type I IFN"
XP_053962261.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053961827.1	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_053958419.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_053949509.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_053969625.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053960125.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_053947765.1	7	Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-165159	"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTOR signalling"
XP_053954592.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053954599.1	7	Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-380320	"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes"
XP_053962018.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_053950707.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053966054.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_053964643.1	14	Reactome: R-HSA-8943723;Reactome: R-HSA-9022692;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-203927;Reactome: R-HSA-8986944;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-426486	"Regulation of PTEN mRNA translation";"Regulation of MECP2 expression and activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"MicroRNA (miRNA) biogenesis";"Transcriptional Regulation by MECP2";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Small interfering RNA (siRNA) biogenesis"
XP_053954055.1	2	Reactome: R-HSA-5205685;Reactome: R-HSA-1268020	"Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import"
XP_053954347.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053949129.1	9	Reactome: R-HSA-114604;Reactome: R-HSA-2871796;Reactome: R-HSA-2029482;Reactome: R-HSA-416482;Reactome: R-HSA-4420097;Reactome: R-HSA-2871809;Reactome: R-HSA-193648;Reactome: R-HSA-5218920;Reactome: R-HSA-194840	"GPVI-mediated activation cascade";"FCERI mediated MAPK activation";"Regulation of actin dynamics for phagocytic cup formation";"G alpha (12/13) signalling events";"VEGFA-VEGFR2 Pathway";"FCERI mediated Ca+2 mobilization";"NRAGE signals death through JNK";"VEGFR2 mediated vascular permeability";"Rho GTPase cycle"
XP_053964584.1	2	Reactome: R-HSA-419812;Reactome: R-HSA-418555	"Calcitonin-like ligand receptors";"G alpha (s) signalling events"
XP_053962232.1	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
XP_053969526.1	12	KEGG: 00450+4.4.1.13;Reactome: R-HSA-71240;MetaCyc: PWY-801;MetaCyc: PWY-601;KEGG: 00380+2.6.1.7;MetaCyc: PWY-7901;MetaCyc: PWY-6842;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6309;MetaCyc: PWY-1187;MetaCyc: PWY-2821;MetaCyc: PWY-6936	"Selenocompound metabolism";"Tryptophan catabolism";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from tryptophan";"Tryptophan metabolism";"Glucosinolate biosynthesis from tyrosine";"Glutathione-mediated detoxification II";"Cysteine and methionine metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glucosinolate biosynthesis from homomethionine";"Glucosinolate biosynthesis from phenylalanine";"Seleno-amino acid biosynthesis (plants)"
XP_053966787.1	83	Reactome: R-HSA-9607240;Reactome: R-HSA-9634285;Reactome: R-HSA-5654720;Reactome: R-HSA-1295596;Reactome: R-HSA-179812;Reactome: R-HSA-2730905;Reactome: R-HSA-5654719;Reactome: R-HSA-167044;Reactome: R-HSA-5654699;Reactome: R-HSA-5637810;Reactome: R-HSA-9026519;Reactome: R-HSA-2029482;Reactome: R-HSA-1963642;Reactome: R-HSA-8853334;Reactome: R-HSA-912526;Reactome: R-HSA-2871809;Reactome: R-HSA-5654704;Reactome: R-HSA-5654727;Reactome: R-HSA-8856828;Reactome: R-HSA-1433557;Reactome: R-HSA-5655291;Reactome: R-HSA-5654726;Reactome: R-HSA-1963640;Reactome: R-HSA-180292;Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-8851805;Reactome: R-HSA-180336;Reactome: R-HSA-5654695;Reactome: R-HSA-354194;Reactome: R-HSA-8875360;Reactome: R-HSA-5654688;Reactome: R-HSA-9664565;Reactome: R-HSA-1250347;Reactome: R-HSA-1250196;Reactome: R-HSA-9034864;Reactome: R-HSA-182971;Reactome: R-HSA-1236382;Reactome: R-HSA-388841;Reactome: R-HSA-1257604;Reactome: R-HSA-6807004;Reactome: R-HSA-9028335;Reactome: R-HSA-8983432;Reactome: R-HSA-112412;Reactome: R-HSA-6811558;Reactome: R-HSA-5654693;Reactome: R-HSA-5654700;Reactome: R-HSA-8875555;Reactome: R-HSA-983695;Reactome: R-HSA-2424491;Reactome: R-HSA-5654710;Reactome: R-HSA-1433559;Reactome: R-HSA-389359;Reactome: R-HSA-5663213;Reactome: R-HSA-391160;Reactome: R-HSA-74751;Reactome: R-HSA-912631;Reactome: R-HSA-5654706;Reactome: R-HSA-8853338;Reactome: R-HSA-210993;Reactome: R-HSA-5654712;Reactome: R-HSA-8865999;Reactome: R-HSA-9645135;Reactome: R-HSA-1839117;Reactome: R-HSA-5654733;Reactome: R-HSA-5654689;Reactome: R-HSA-512988;Reactome: R-HSA-2219530;Reactome: R-HSA-5655302;Reactome: R-HSA-8875656;Reactome: R-HSA-2871796;Reactome: R-HSA-186763;Reactome: R-HSA-5655253;Reactome: R-HSA-8851907;Reactome: R-HSA-8853659;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-2428933;Reactome: R-HSA-8856825;Reactome: R-HSA-9027284;Reactome: R-HSA-5654732;Reactome: R-HSA-74749;Reactome: R-HSA-9028731	"FLT3 Signaling";"Constitutive Signaling by Overexpressed ERBB2";"PI-3K cascade:FGFR4";"Spry regulation of FGF signaling";"GRB2 events in EGFR signaling";"Role of LAT2/NTAL/LAB on calcium mobilization";"SHC-mediated cascade:FGFR4";"Signalling to RAS";"SHC-mediated cascade:FGFR2";"Constitutive Signaling by EGFRvIII";"Activated NTRK2 signals through RAS";"Regulation of actin dynamics for phagocytic cup formation";"PI3K events in ERBB2 signaling";"Signaling by FGFR3 fusions in cancer";"Interleukin receptor SHC signaling";"FCERI mediated Ca+2 mobilization";"SHC-mediated cascade:FGFR3";"Negative regulation of FGFR2 signaling";"Clathrin-mediated endocytosis";"Signaling by SCF-KIT";"Signaling by FGFR4 in disease";"Negative regulation of FGFR1 signaling";"GRB2 events in ERBB2 signaling";"GAB1 signalosome";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"MET activates RAS signaling";"SHC1 events in EGFR signaling";"PI-3K cascade:FGFR2";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"InlB-mediated entry of Listeria monocytogenes into host cell";"SHC-mediated cascade:FGFR1";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB4 signaling";"SHC1 events in ERBB2 signaling";"Activated NTRK3 signals through RAS";"EGFR downregulation";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Costimulation by the CD28 family";"PIP3 activates AKT signaling";"Negative regulation of MET activity";"Activated NTRK2 signals through PI3K";"Interleukin-15 signaling";"SOS-mediated signalling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR2 signaling";"MET activates RAP1 and RAC1";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"DAP12 signaling";"PI-3K cascade:FGFR3";"Regulation of KIT signaling";"CD28 dependent Vav1 pathway";"RHO GTPases Activate WASPs and WAVEs";"Signal regulatory protein family interactions";"Insulin receptor signalling cascade";"Regulation of signaling by CBL";"FRS-mediated FGFR3 signaling";"Signaling by FGFR3 point mutants in cancer";"Tie2 Signaling";"FRS-mediated FGFR4 signaling";"MET activates PTPN11";"STAT5 Activation";"Signaling by cytosolic FGFR1 fusion mutants";"Negative regulation of FGFR4 signaling";"PI-3K cascade:FGFR1";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Signaling by FGFR1 in disease";"MET receptor recycling";"FCERI mediated MAPK activation";"Downstream signal transduction";"Signaling by FGFR2 in disease";"MET activates PI3K/AKT signaling";"RET signaling";"EGFR Transactivation by Gastrin";"PI3K Cascade";"SHC-related events triggered by IGF1R";"Cargo recognition for clathrin-mediated endocytosis";"Erythropoietin activates RAS";"Negative regulation of FGFR3 signaling";"Signal attenuation";"Activated NTRK2 signals through FRS2 and FRS3"
XP_053966762.1	6	Reactome: R-HSA-428930;Reactome: R-HSA-456926;Reactome: R-HSA-399997;Reactome: R-HSA-416476;Reactome: R-HSA-418592;Reactome: R-HSA-434316	"Thromboxane signalling through TP receptor";"Thrombin signalling through proteinase activated receptors (PARs)";"Acetylcholine regulates insulin secretion";"G alpha (q) signalling events";"ADP signalling through P2Y purinoceptor 1";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"
XP_053969368.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_053954066.1	7	MetaCyc: PWY-7586;MetaCyc: PWY-882;KEGG: 00051+5.4.2.8;KEGG: 00520+5.4.2.8;MetaCyc: PWY-7456;Reactome: R-HSA-446205;MetaCyc: PWY-5659	"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"L-ascorbate biosynthesis I (L-galactose pathway)";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Beta-(1,4)-mannan degradation";"Synthesis of GDP-mannose";"GDP-mannose biosynthesis"
XP_053955489.1	4	Reactome: R-HSA-5676590;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"NIK-->noncanonical NF-kB signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_053959498.1	13	MetaCyc: PWY-7222;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-7198;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7210;MetaCyc: PWY-7227;MetaCyc: PWY-6545;Reactome: R-HSA-499943;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7226;MetaCyc: PWY-7184;KEGG: 00240+1.17.4.1	"Guanosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Purine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Interconversion of nucleotide di- and triphosphates";"Drug metabolism - other enzymes";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism"
XP_053952175.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_053950609.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_053966011.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Ion channel transport";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
XP_053966504.1	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
XP_053964707.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053947403.1	4	MetaCyc: PWY-6483;MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662	"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism";"Glycosphingolipid metabolism"
XP_053966124.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_053964062.1	56	Reactome: R-HSA-5362768;Reactome: R-HSA-349425;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-5668541;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-4641258;Reactome: R-HSA-1236978;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-180585;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-5632684;Reactome: R-HSA-8854050;Reactome: R-HSA-5607764;Reactome: R-HSA-174084;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-450408;Reactome: R-HSA-69017;Reactome: R-HSA-5610783;Reactome: R-HSA-4608870;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-5689880;Reactome: R-HSA-5658442;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-1236974;Reactome: R-HSA-983168;Reactome: R-HSA-8939902;Reactome: R-HSA-69481;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-174154;Reactome: R-HSA-8852276;Reactome: R-HSA-174113;Reactome: R-HSA-68827	"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of the E3 ubiquitin ligase COP1";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TNFR2 non-canonical NF-kB pathway";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Degradation of DVL";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Hedgehog 'on' state";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"CLEC7A (Dectin-1) signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI2 by the proteasome";"Asymmetric localization of PCP proteins";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"Ub-specific processing proteases";"Regulation of RAS by GAPs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ER-Phagosome pathway";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX2 expression and activity";"G2/M Checkpoints";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdc20 mediated degradation of Securin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF-beta-TrCP mediated degradation of Emi1";"CDT1 association with the CDC6:ORC:origin complex"
XP_053964695.1	2	MetaCyc: PWY-7799;MetaCyc: PWY-7802	"Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)"
XP_053961287.1	16	Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72695	"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex"
XP_053961262.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053957194.1	4	Reactome: R-HSA-111465;Reactome: R-HSA-5689880;Reactome: R-HSA-176187;Reactome: R-HSA-5693607	"Apoptotic cleavage of cellular proteins";"Ub-specific processing proteases";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends"
XP_053964069.1	1	Reactome: R-HSA-196783	"Coenzyme A biosynthesis"
XP_053946185.1	2	Reactome: R-HSA-140875;Reactome: R-HSA-202733	"Common Pathway of Fibrin Clot Formation";"Cell surface interactions at the vascular wall"
XP_053954606.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_053949059.1	10	Reactome: R-HSA-977225;Reactome: R-HSA-975634;Reactome: R-HSA-3000171;KEGG: 00230+3.5.2.17;Reactome: R-HSA-2453864;Reactome: R-HSA-6798695;MetaCyc: PWY-7394;MetaCyc: PWY-7849;MetaCyc: PWY-5691;Reactome: R-HSA-2453902	"Amyloid fiber formation";"Retinoid metabolism and transport";"Non-integrin membrane-ECM interactions";"Purine metabolism";"Retinoid cycle disease events";"Neutrophil degranulation";"Urate conversion to allantoin II";"Urate conversion to allantoin III";"Urate conversion to allantoin I";"The canonical retinoid cycle in rods (twilight vision)"
XP_053966557.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053956471.1	3	MetaCyc: PWY-6368;KEGG: 04070+3.1.3.78;MetaCyc: PWY-6367	"3-phosphoinositide degradation";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism"
XP_053950711.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053965549.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_053962500.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_053954444.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053949052.1	5	Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-983712	"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Ion channel transport"
XP_053962964.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053966853.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_053965542.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053968248.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_053949930.1	3	Reactome: R-HSA-73621;Reactome: R-HSA-196807;Reactome: R-HSA-74259	"Pyrimidine catabolism";"Nicotinate metabolism";"Purine catabolism"
XP_053965733.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_053962508.1	5	Reactome: R-HSA-70263;KEGG: 00620+4.1.1.32;KEGG: 00020+4.1.1.32;MetaCyc: PWY-7383;KEGG: 00010+4.1.1.32	"Gluconeogenesis";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis / Gluconeogenesis"
XP_053961931.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_053960015.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_053958746.1	1	Reactome: R-HSA-5689603	"UCH proteinases"
XP_053948825.1	4	Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"DARPP-32 events";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_053953189.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_053962128.1	6	Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-156827	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_053961962.1	14	MetaCyc: PWY-6969;Reactome: R-HSA-611105;MetaCyc: PWY-3781;MetaCyc: PWY-5690;KEGG: 00720+1.3.5.1;MetaCyc: PWY-7279;Reactome: R-HSA-71403;MetaCyc: PWY-6728;KEGG: 00190+1.3.5.1;KEGG: 00020+1.3.5.1;MetaCyc: PWY-7254;MetaCyc: PWY-561;KEGG: 00650+1.3.5.1;MetaCyc: PWY-4302	"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Respiratory electron transport";"Aerobic respiration I (cytochrome c)";"TCA cycle II (plants and fungi)";"Carbon fixation pathways in prokaryotes";"Aerobic respiration II (cytochrome c) (yeast)";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Oxidative phosphorylation";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Butanoate metabolism";"Aerobic respiration III (alternative oxidase pathway)"
XP_053952698.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053949012.1	4	Reactome: R-HSA-6798695;Reactome: R-HSA-879415;Reactome: R-HSA-1799339;Reactome: R-HSA-446203	"Neutrophil degranulation";"Advanced glycosylation endproduct receptor signaling";"SRP-dependent cotranslational protein targeting to membrane";"Asparagine N-linked glycosylation"
XP_053950475.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_053965674.1	3	Reactome: R-HSA-3232118;Reactome: R-HSA-3899300;Reactome: R-HSA-4090294	"SUMOylation of transcription factors";"SUMOylation of transcription cofactors";"SUMOylation of intracellular receptors"
XP_053953830.1	6	MetaCyc: PWY-7346;KEGG: 00040+1.1.1.22;KEGG: 00520+1.1.1.22;Reactome: R-HSA-173599;MetaCyc: PWY-7820;KEGG: 00053+1.1.1.22	"UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)";"Pentose and glucuronate interconversions";"Amino sugar and nucleotide sugar metabolism";"Formation of the active cofactor, UDP-glucuronate";"Teichuronic acid biosynthesis (B. subtilis 168)";"Ascorbate and aldarate metabolism"
XP_053956715.1	6	Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68867	"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"Unwinding of DNA";"Assembly of the pre-replicative complex"
XP_053965336.1	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
XP_053966813.1	7	KEGG: 00565+3.1.4.4;Reactome: R-HSA-2029485;Reactome: R-HSA-1483148;MetaCyc: PWY-7039;KEGG: 00564+3.1.4.4;Reactome: R-HSA-1483166;MetaCyc: PWY-3561	"Ether lipid metabolism";"Role of phospholipids in phagocytosis";"Synthesis of PG";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Synthesis of PA";"Choline biosynthesis III"
XP_053964833.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_053958309.1	6	MetaCyc: PWY-7433;KEGG: 00512+2.4.1.122;Reactome: R-HSA-5083632;KEGG: 00514+2.4.1.122;MetaCyc: PWY-7290;Reactome: R-HSA-913709	"Mucin core 1 and core 2 O-glycosylation";"Mucin type O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Other types of O-glycan biosynthesis";"Escherichia coli serotype O86 O-antigen biosynthesis";"O-linked glycosylation of mucins"
XP_053964537.1	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
XP_053966517.1	5	MetaCyc: PWY-7511;Reactome: R-HSA-381038;Reactome: R-HSA-5358346;Reactome: R-HSA-901032;Reactome: R-HSA-5362768	"Protein ubiquitination";"XBP1(S) activates chaperone genes";"Hedgehog ligand biogenesis";"ER Quality Control Compartment (ERQC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD"
XP_053962264.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_053966734.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_053964714.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_053957026.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_053962902.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_053965884.1	18	KEGG: 00592+3.1.1.4;Reactome: R-HSA-1482922;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00565+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7783;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925;MetaCyc: PWY-7417;MetaCyc: PWY-8053;Reactome: R-HSA-1482801;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482839	"alpha-Linolenic acid metabolism";"Acyl chain remodelling of PI";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Ether lipid metabolism";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Plasmalogen degradation";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PS";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PE"
XP_053969323.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_053969197.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
XP_053968491.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_053950127.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_053967271.1	7	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
XP_053960990.1	5	Reactome: R-HSA-197264;MetaCyc: PWY-5381;Reactome: R-HSA-1368108;KEGG: 00760+6.3.4.21;Reactome: R-HSA-6798695	"Nicotinamide salvaging";"Pyridine nucleotide cycling (plants)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinate and nicotinamide metabolism";"Neutrophil degranulation"
XP_053949702.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_053946308.1	2	Reactome: R-HSA-5339700;Reactome: R-HSA-4641265	"TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes"
XP_053966531.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_053964004.1	23	Reactome: R-HSA-4086398;Reactome: R-HSA-202040;Reactome: R-HSA-418555;Reactome: R-HSA-392451;Reactome: R-HSA-418217;Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-381676;Reactome: R-HSA-392170;Reactome: R-HSA-418592;Reactome: R-HSA-6814122;Reactome: R-HSA-9009391;Reactome: R-HSA-416482;Reactome: R-HSA-392851;Reactome: R-HSA-500657;Reactome: R-HSA-420092;Reactome: R-HSA-428930;Reactome: R-HSA-432040;Reactome: R-HSA-400042;Reactome: R-HSA-8964315;Reactome: R-HSA-8964616;Reactome: R-HSA-418594;Reactome: R-HSA-456926	"Ca2+ pathway";"G-protein activation";"G alpha (s) signalling events";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through PLC beta";"G alpha (q) signalling events";"G alpha (z) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 12";"ADP signalling through P2Y purinoceptor 1";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Extra-nuclear estrogen signaling";"G alpha (12/13) signalling events";"Prostacyclin signalling through prostacyclin receptor";"Presynaptic function of Kainate receptors";"Glucagon-type ligand receptors";"Thromboxane signalling through TP receptor";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adrenaline,noradrenaline inhibits insulin secretion";"G beta:gamma signalling through BTK";"G beta:gamma signalling through CDC42";"G alpha (i) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)"
XP_053950554.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_053952340.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_053965647.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_053949871.1	17	Reactome: R-HSA-450321;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-445989;Reactome: R-HSA-9645460;Reactome: R-HSA-937042;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-5689880;Reactome: R-HSA-975163;Reactome: R-HSA-450302;Reactome: R-HSA-9014325;Reactome: R-HSA-4086398;Reactome: R-HSA-937072;Reactome: R-HSA-9020702	"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Alpha-protein kinase 1 signaling pathway";"IRAK2 mediated activation of TAK1 complex";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Ub-specific processing proteases";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"activated TAK1 mediates p38 MAPK activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Ca2+ pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Interleukin-1 signaling"
XP_053969726.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_053963945.1	3	MetaCyc: PWY-6829;MetaCyc: PWY-7888;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"Trna-uridine 2-thiolation (cytoplasmic)";"tRNA modification in the nucleus and cytosol"
XP_053946898.1	6	KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952;Reactome: R-HSA-975578;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7426;MetaCyc: PWY-7920	"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Reactions specific to the complex N-glycan synthesis pathway";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)"
XP_053966562.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_053965248.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_053964057.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_053961326.1	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
XP_053947655.1	6	Reactome: R-HSA-446210;MetaCyc: PWY-6906;MetaCyc: PWY-7395;KEGG: 00520+3.5.1.25;KEGG: 00052+3.5.1.25;MetaCyc: PWY-7077	"Synthesis of UDP-N-acetyl-glucosamine";"Chitin derivatives degradation";"D-galactosamine and N-acetyl-D-galactosamine degradation";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"N-acetyl-D-galactosamine degradation"
XP_053961257.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_053961568.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_053960705.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053950849.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_053965456.1	5	MetaCyc: PWY-7269;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_053961618.1	5	MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085;MetaCyc: PWY-7822;MetaCyc: PWY-6855	"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate";"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)"
XP_053962202.1	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
XP_053967971.1	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_053946890.1	12	Reactome: R-HSA-177929;Reactome: R-HSA-2691232;Reactome: R-HSA-2644606;Reactome: R-HSA-1442490;Reactome: R-HSA-193692;Reactome: R-HSA-2894862;Reactome: R-HSA-982772;Reactome: R-HSA-1251985;Reactome: R-HSA-2122948;Reactome: R-HSA-75893;Reactome: R-HSA-5362798;Reactome: R-HSA-2660826	"Signaling by EGFR";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Collagen degradation";"Regulated proteolysis of p75NTR";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Growth hormone receptor signaling";"Nuclear signaling by ERBB4";"Activated NOTCH1 Transmits Signal to the Nucleus";"TNF signaling";"Release of Hh-Np from the secreting cell";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant"
XP_053962209.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_053949561.1	6	Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_053959220.1	22	Reactome: R-HSA-195253;Reactome: R-HSA-5663220;Reactome: R-HSA-5467340;Reactome: R-HSA-5675221;Reactome: R-HSA-432142;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-6811558;Reactome: R-HSA-68877;Reactome: R-HSA-5358751;Reactome: R-HSA-5467348;Reactome: R-HSA-2467813;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-5673000;Reactome: R-HSA-196299;Reactome: R-HSA-2500257	"Degradation of beta-catenin by the destruction complex";"RHO GTPases Activate Formins";"AXIN missense mutants destabilize the destruction complex";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Mitotic Prometaphase";"S45 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"Separation of Sister Chromatids";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"RAF activation";"Beta-catenin phosphorylation cascade";"Resolution of Sister Chromatid Cohesion"
XP_053964639.1	14	Reactome: R-HSA-8986944;Reactome: R-HSA-203927;Reactome: R-HSA-5628897;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-426486;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398	"Transcriptional Regulation by MECP2";"MicroRNA (miRNA) biogenesis";"TP53 Regulates Metabolic Genes";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Small interfering RNA (siRNA) biogenesis";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway"
XP_053950514.1	10	Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-6807505;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-167162	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA polymerase II transcribes snRNA genes";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape"
XP_053950737.1	2	KEGG: 00970+6.1.1.21;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_053961904.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_053964632.1	3	Reactome: R-HSA-6804760;Reactome: R-HSA-191859;Reactome: R-HSA-3214858	"Regulation of TP53 Activity through Methylation";"snRNP Assembly";"RMTs methylate histone arginines"
XP_053950781.1	8	Reactome: R-HSA-438066;MetaCyc: PWY-7221;Reactome: R-HSA-5673001;KEGG: 00230+2.7.4.8;Reactome: R-HSA-9620244;Reactome: R-HSA-9617324;Reactome: R-HSA-442982;Reactome: R-HSA-9609736	"Unblocking of NMDA receptors, glutamate binding and activation";"Guanosine ribonucleotides de novo biosynthesis";"RAF/MAP kinase cascade";"Purine metabolism";"Long-term potentiation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Ras activation upon Ca2+ influx through NMDA receptor";"Assembly and cell surface presentation of NMDA receptors"
XP_053963026.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_053946115.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_053949532.1	3	Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2206291	"HS-GAG degradation";"Neutrophil degranulation";"MPS IIIC - Sanfilippo syndrome C"
XP_053952348.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_053946300.1	1	Reactome: R-HSA-6785631	"ERBB2 Regulates Cell Motility"
XP_053965416.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_053953152.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling"
XP_053966037.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_053949651.1	11	Reactome: R-HSA-9013508;Reactome: R-HSA-2122947;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-210744;Reactome: R-HSA-2894862;Reactome: R-HSA-1912408;Reactome: R-HSA-9013695;Reactome: R-HSA-72163;Reactome: R-HSA-350054;Reactome: R-HSA-2173796	"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"NOTCH4 Intracellular Domain Regulates Transcription";"mRNA Splicing - Major Pathway";"Notch-HLH transcription pathway";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"
XP_053960374.1	42	Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-1912408;Reactome: R-HSA-73772;Reactome: R-HSA-3214847;Reactome: R-HSA-110331;Reactome: R-HSA-5693607;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-427413;Reactome: R-HSA-69473;Reactome: R-HSA-110330;Reactome: R-HSA-3214842;Reactome: R-HSA-2299718;Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-5250924;Reactome: R-HSA-73728;Reactome: R-HSA-3214858;Reactome: R-HSA-5625886;Reactome: R-HSA-2559586;Reactome: R-HSA-5693565;Reactome: R-HSA-110329;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-5334118;Reactome: R-HSA-1221632;Reactome: R-HSA-171306;Reactome: R-HSA-9018519;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-606279;Reactome: R-HSA-2559582;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-912446	"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"Pre-NOTCH Transcription and Translation";"RNA Polymerase I Promoter Escape";"HATs acetylate histones";"Cleavage of the damaged purine";"Processing of DNA double-strand break ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"NoRC negatively regulates rRNA expression";"G2/M DNA damage checkpoint";"Recognition and association of DNA glycosylase with site containing an affected purine";"HDMs demethylate histones";"Condensation of Prophase Chromosomes";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Opening";"RMTs methylate histone arginines";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"DNA Damage/Telomere Stress Induced Senescence";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cleavage of the damaged pyrimidine";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"DNA methylation";"Meiotic synapsis";"Packaging Of Telomere Ends";"Estrogen-dependent gene expression";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere";"Senescence-Associated Secretory Phenotype (SASP)";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"Meiotic recombination"
XP_053969136.1	6	Reactome: R-HSA-4411364;Reactome: R-HSA-3769402;Reactome: R-HSA-8951430;Reactome: R-HSA-4086398;Reactome: R-HSA-4641265;Reactome: R-HSA-201722	"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex";"RUNX3 regulates WNT signaling";"Ca2+ pathway";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex"
XP_053947615.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"