Accession_ID Pathway_Count Pathway_IDs Pathway_Names lcl|NW_020311294.1_prot_XP_020711023.1_868 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311966.1_prot_XP_020708440.1_14447 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" lcl|NW_020311925.1_prot_XP_012252618.1_10528 7 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase" lcl|NW_020311381.1_prot_XP_012252346.1_6828 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311334.1_prot_XP_020711364.1_4381 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311294.1_prot_XP_020711012.1_879 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311292.1_prot_XP_012252463.1_529 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" lcl|NW_020311984.1_prot_XP_012254602.1_19911 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" lcl|NW_020311308.1_prot_XP_020707136.1_2226 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311993.1_prot_XP_012265174.1_21491 1 Reactome: R-HSA-6790901 "rRNA modification in the nucleus and cytosol" lcl|NW_020311995.1_prot_XP_012256179.2_21994 6 Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68949;Reactome: R-HSA-68867 "Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex" lcl|NW_020311318.1_prot_XP_012253631.1_3273 6 Reactome: R-HSA-201722;Reactome: R-HSA-2173796;Reactome: R-HSA-3769402;Reactome: R-HSA-5626467;Reactome: R-HSA-381426;Reactome: R-HSA-8957275 "Formation of the beta-catenin:TCF transactivating complex";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Deactivation of the beta-catenin transactivating complex";"RHO GTPases activate IQGAPs";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation" lcl|NW_020311346.1_prot_XP_012262958.1_4987 7 MetaCyc: PWY-7839;MetaCyc: PWY-7838;MetaCyc: PWY-7836;MetaCyc: PWY-5129;KEGG: 00600+2.4.1.80;Reactome: R-HSA-1660662;MetaCyc: PWY-7841 "Lacto-series glycosphingolipids biosynthesis";"Globo-series glycosphingolipids biosynthesis";"Ganglio-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)";"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Neolacto-series glycosphingolipids biosynthesis" lcl|NW_020311369.1_prot_XP_012264137.1_6235 5 MetaCyc: PWY-6168;KEGG: 00740+2.7.1.26;Reactome: R-HSA-196843;MetaCyc: PWY-5523;MetaCyc: PWY-7863 "Flavin biosynthesis III (fungi)";"Riboflavin metabolism";"Vitamin B2 (riboflavin) metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Roseoflavin biosynthesis" lcl|NW_020311974.1_prot_XP_012259794.1_16734 6 KEGG: 00230+3.5.4.3;MetaCyc: PWY-5497;MetaCyc: PWY-7442;Reactome: R-HSA-74259;MetaCyc: PWY-6608;MetaCyc: PWY-6606 "Purine metabolism";"Purine nucleobases degradation II (anaerobic)";"Drosopterin and aurodrosopterin biosynthesis";"Purine catabolism";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II" lcl|NW_020311943.1_prot_XP_012255287.1_11633 6 Reactome: R-HSA-9029569;Reactome: R-HSA-1989781;Reactome: R-HSA-9022692;Reactome: R-HSA-9609690;Reactome: R-HSA-9022537;Reactome: R-HSA-3214815 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"PPARA activates gene expression";"Regulation of MECP2 expression and activity";"HCMV Early Events";"Loss of MECP2 binding ability to the NCoR/SMRT complex";"HDACs deacetylate histones" lcl|NW_020311973.1_prot_XP_012258649.1_16568 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" lcl|NW_020311965.1_prot_XP_012260179.1_14109 1 Reactome: R-HSA-8943724 "Regulation of PTEN gene transcription" lcl|NW_020311356.1_prot_XP_020711745.1_5552 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" lcl|NW_020311300.1_prot_XP_012253148.1_1499 7 Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311395.1_prot_XP_012260734.1_7229 7 Reactome: R-HSA-203927;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-1655829;Reactome: R-HSA-180746 "MicroRNA (miRNA) biogenesis";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Nuclear import of Rev protein" lcl|NW_020311401.1_prot_XP_020707761.1_7584 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311976.1_prot_XP_012253442.1_17218 2 Reactome: R-HSA-983168;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation" lcl|NW_020311934.1_prot_XP_012255028.1_10830 6 Reactome: R-HSA-1268020;MetaCyc: PWY-7980;Reactome: R-HSA-8949613;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2;Reactome: R-HSA-163210 "Mitochondrial protein import";"ATP biosynthesis";"Cristae formation";"Oxidative phosphorylation";"Photosynthesis";"Formation of ATP by chemiosmotic coupling" lcl|NW_020311432.1_prot_XP_012268911.1_8343 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311401.1_prot_XP_012255376.1_7620 30 Reactome: R-HSA-211163;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-111447;KEGG: 04714+2.7.11.1;Reactome: R-HSA-69202;Reactome: R-HSA-9634638;KEGG: 04150+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-8948751;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5218920;Reactome: R-HSA-5674400;Reactome: R-HSA-6804758;Reactome: R-HSA-6804759;Reactome: R-HSA-198323;Reactome: R-HSA-5628897;KEGG: 04926+2.7.11.1;Reactome: R-HSA-8941332;Reactome: R-HSA-8876198;KEGG: 05170+2.7.11.1;Reactome: R-HSA-392451;Reactome: R-HSA-1358803;KEGG: 04151+2.7.11.1;Reactome: R-HSA-389513;KEGG: 05165+2.7.11.1;Reactome: R-HSA-69656;Reactome: R-HSA-198693;Reactome: R-HSA-9614399;Reactome: R-HSA-199418 "AKT-mediated inactivation of FOXO1A";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"Activation of BAD and translocation to mitochondria";"Thermogenesis";"Cyclin E associated events during G1/S transition";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"mTOR signaling pathway";"CD28 dependent PI3K/Akt signaling";"Regulation of PTEN stability and activity";"Human cytomegalovirus infection";"VEGFR2 mediated vascular permeability";"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of TP53 Activity through Acetylation";"Regulation of TP53 Activity through Association with Co-factors";"AKT phosphorylates targets in the cytosol";"TP53 Regulates Metabolic Genes";"Relaxin signaling pathway";"RUNX2 regulates genes involved in cell migration";"RAB GEFs exchange GTP for GDP on RABs";"Human immunodeficiency virus 1 infection";"G beta:gamma signalling through PI3Kgamma";"Downregulation of ERBB2:ERBB3 signaling";"PI3K-Akt signaling pathway";"CTLA4 inhibitory signaling";"Human papillomavirus infection";"Cyclin A:Cdk2-associated events at S phase entry";"AKT phosphorylates targets in the nucleus";"Regulation of localization of FOXO transcription factors";"Negative regulation of the PI3K/AKT network" lcl|NW_020311982.1_prot_XP_020708731.1_19230 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311934.1_prot_XP_012255340.1_10858 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311360.1_prot_XP_012251601.1_5749 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311983.1_prot_XP_020712111.1_19635 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311302.1_prot_XP_012264513.1_1686 26 Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-437239;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-8955332;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-1445148;Reactome: R-HSA-389977;Reactome: R-HSA-389960;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-190861;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-5617833;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276 "RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"Recycling pathway of L1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"RHO GTPases Activate Formins";"Carboxyterminal post-translational modifications of tubulin";"Aggrephagy";"Separation of Sister Chromatids";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Post-chaperonin tubulin folding pathway";"Formation of tubulin folding intermediates by CCT/TriC";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"Gap junction assembly";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Cilium Assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint" lcl|NW_020311992.1_prot_XP_020711546.1_21137 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" lcl|NW_020311980.1_prot_XP_012261338.1_18785 7 Reactome: R-HSA-1855183;MetaCyc: PWY-2301;KEGG: 00562+3.1.3.25;KEGG: 00521+3.1.3.25;KEGG: 04070+3.1.3.25;MetaCyc: PWY-4702;MetaCyc: PWY-6363 "Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"Inositol phosphate metabolism";"Streptomycin biosynthesis";"Phosphatidylinositol signaling system";"Phytate degradation I";"D-myo-inositol (1,4,5)-trisphosphate degradation" lcl|NW_020311373.1_prot_XP_012266699.1_6485 16 Reactome: R-HSA-141430;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-174084;Reactome: R-HSA-983168;Reactome: R-HSA-176412;Reactome: R-HSA-176408;Reactome: R-HSA-179409;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-174178;Reactome: R-HSA-176407 "Inactivation of APC/C via direct inhibition of the APC/C complex";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"Phosphorylation of the APC/C";"Regulation of APC/C activators between G1/S and early anaphase";"APC-Cdc20 mediated degradation of Nek2A";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" lcl|NW_020311476.1_prot_XP_020707405.1_9417 5 Reactome: R-HSA-4655427;Reactome: R-HSA-5334118;Reactome: R-HSA-427413;KEGG: 00270+2.1.1.37;Reactome: R-HSA-212300 "SUMOylation of DNA methylation proteins";"DNA methylation";"NoRC negatively regulates rRNA expression";"Cysteine and methionine metabolism";"PRC2 methylates histones and DNA" lcl|NW_020311917.1_prot_XP_012250988.1_10251 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311971.1_prot_XP_012263603.1_16036 3 Reactome: R-HSA-2024096;Reactome: R-HSA-2206291;Reactome: R-HSA-6798695 "HS-GAG degradation";"MPS IIIC - Sanfilippo syndrome C";"Neutrophil degranulation" lcl|NW_020311978.1_prot_XP_012257710.1_18113 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311978.1_prot_XP_025602794.1_18035 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" lcl|NW_020311973.1_prot_XP_020708835.1_16399 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311962.1_prot_XP_012251913.1_13662 4 Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942 "Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)" lcl|NW_020311477.1_prot_XP_012262232.1_9425 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311940.1_prot_XP_012252805.1_11131 6 Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695 "Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex" lcl|NW_020311980.1_prot_XP_025602831.1_18757 2 Reactome: R-HSA-975577;Reactome: R-HSA-2022854 "N-Glycan antennae elongation";"Keratan sulfate biosynthesis" lcl|NW_020311977.1_prot_XP_020710649.1_17803 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311977.1_prot_XP_012263704.1_17721 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" lcl|NW_020311994.1_prot_XP_012267538.1_21759 3 KEGG: 00240+1.3.5.2;MetaCyc: PWY-5686;Reactome: R-HSA-500753 "Pyrimidine metabolism";"UMP biosynthesis I";"Pyrimidine biosynthesis" lcl|NW_020311313.1_prot_XP_012261847.1_2906 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311984.1_prot_XP_025602898.1_19844 4 Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex" lcl|NW_020311966.1_prot_XP_012256377.1_14951 7 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5626467;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins" lcl|NW_020311994.1_prot_XP_012267523.1_21682 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311984.1_prot_XP_012254617.1_19908 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" lcl|NW_020311349.1_prot_XP_012262426.1_5159 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311368.1_prot_XP_012264428.1_6215 4 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"DARPP-32 events" lcl|NW_020311950.1_prot_XP_012250672.1_12183 2 Reactome: R-HSA-189451;KEGG: 00860+4.99.1.1 "Heme biosynthesis";"Porphyrin and chlorophyll metabolism" lcl|NW_020311987.1_prot_XP_012266015.1_20359 7 Reactome: R-HSA-6807878;Reactome: R-HSA-264870;Reactome: R-HSA-373753;Reactome: R-HSA-5673001;Reactome: R-HSA-445095;Reactome: R-HSA-6798695;Reactome: R-HSA-375165 "COPI-mediated anterograde transport";"Caspase-mediated cleavage of cytoskeletal proteins";"Nephrin family interactions";"RAF/MAP kinase cascade";"Interaction between L1 and Ankyrins";"Neutrophil degranulation";"NCAM signaling for neurite out-growth" lcl|NW_020311943.1_prot_XP_020707685.1_11743 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311994.1_prot_XP_020710043.1_21842 4 Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-2022090;Reactome: R-HSA-1650814 "Collagen chain trimerization";"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures";"Collagen biosynthesis and modifying enzymes" lcl|NW_020311961.1_prot_XP_020710186.1_13430 1 Reactome: R-HSA-9033241 "Peroxisomal protein import" lcl|NW_020311293.1_prot_XP_012263597.1_858 1 Reactome: R-HSA-532668 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" lcl|NW_020311932.1_prot_XP_012257424.1_10711 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" lcl|NW_020311342.1_prot_XP_020707960.1_4727 10 Reactome: R-HSA-9013508;Reactome: R-HSA-350054;Reactome: R-HSA-8941856;Reactome: R-HSA-210744;Reactome: R-HSA-2197563;Reactome: R-HSA-2122947;Reactome: R-HSA-1912408;Reactome: R-HSA-2894862;Reactome: R-HSA-9013695;Reactome: R-HSA-2644606 "NOTCH3 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"RUNX3 regulates NOTCH signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH2 intracellular domain regulates transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" lcl|NW_020311983.1_prot_XP_012255544.1_19747 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311939.1_prot_XP_012251679.1_11068 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" lcl|NW_020311990.1_prot_XP_012266707.1_20823 1 KEGG: 00970+6.1.1.7 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311995.1_prot_XP_020708172.1_22065 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311513.1_prot_XP_020711446.1_9718 1 Reactome: R-HSA-2142789 "Ubiquinol biosynthesis" lcl|NW_020311976.1_prot_XP_012257270.1_17416 1 Reactome: R-HSA-5693565 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" lcl|NW_020311360.1_prot_XP_012251592.1_5732 6 Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-69052;Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-68949 "Unwinding of DNA";"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin" lcl|NW_020311347.1_prot_XP_020711382.1_5036 10 MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2206292;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2160916 "Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"MPS VII - Sly syndrome";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Neutrophil degranulation";"HS-GAG degradation";"Glycosaminoglycan degradation";"Other glycan degradation";"Hyaluronan uptake and degradation" lcl|NW_020311441.1_prot_XP_012251198.1_8906 4 Reactome: R-HSA-379716;Reactome: R-HSA-2408522;Reactome: R-HSA-379726;KEGG: 00970+6.1.1.6 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311918.1_prot_XP_012265011.1_10357 13 Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-6791226 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311984.1_prot_XP_012267667.1_20122 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" lcl|NW_020311502.1_prot_XP_012251082.1_9601 17 Reactome: R-HSA-2559586;Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568;Reactome: R-HSA-912446;Reactome: R-HSA-3270619;Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;Reactome: R-HSA-5685942;Reactome: R-HSA-5685939;Reactome: R-HSA-5685938;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-5693548;Reactome: R-HSA-5693554 "DNA Damage/Telomere Stress Induced Senescence";"Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic recombination";"IRF3-mediated induction of type I IFN";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"HDR through Homologous Recombination (HRR)";"HDR through MMEJ (alt-NHEJ)";"HDR through Single Strand Annealing (SSA)";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"Sensing of DNA Double Strand Breaks";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" lcl|NW_020311306.1_prot_XP_012264239.1_2057 5 Reactome: R-HSA-1237112;Reactome: R-HSA-111458;KEGG: 00270+4.2.1.109;Reactome: R-HSA-9627069;MetaCyc: PWY-4361 "Methionine salvage pathway";"Formation of apoptosome";"Cysteine and methionine metabolism";"Regulation of the apoptosome activity";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I" lcl|NW_020311334.1_prot_XP_012265935.1_4350 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311978.1_prot_XP_020708605.1_18243 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311978.1_prot_XP_012257963.1_18238 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311326.1_prot_XP_012261518.1_3719 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311425.1_prot_XP_012265062.1_8241 3 Reactome: R-HSA-6807004;Reactome: R-HSA-6798695;Reactome: R-HSA-202427 "Negative regulation of MET activity";"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains" lcl|NW_020311917.1_prot_XP_020706447.1_10240 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311667.1_prot_XP_012261221.1_10096 1 KEGG: 00970+6.1.1.2 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311513.1_prot_XP_012266153.1_9828 6 MetaCyc: PWY-6118;MetaCyc: PWY-6952;Reactome: R-HSA-1483166;Reactome: R-HSA-163560;MetaCyc: PWY-4261;KEGG: 00564+1.1.5.3 "Glycerol-3-phosphate shuttle";"Glycerophosphodiester degradation";"Synthesis of PA";"Triglyceride catabolism";"Glycerol degradation I";"Glycerophospholipid metabolism" lcl|NW_020311995.1_prot_XP_012256710.1_21914 3 KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317 "Glycolysis / Gluconeogenesis";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)" lcl|NW_020311918.1_prot_XP_020710195.1_10301 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" lcl|NW_020311992.1_prot_XP_012266556.1_21111 1 Reactome: R-HSA-71403 "Citric acid cycle (TCA cycle)" lcl|NW_020311940.1_prot_XP_012265673.1_11248 1 Reactome: R-HSA-140342 "Apoptosis induced DNA fragmentation" lcl|NW_020311365.1_prot_XP_012260304.1_5939 1 Reactome: R-HSA-71288 "Creatine metabolism" lcl|NW_020311966.1_prot_XP_020708408.1_15109 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" lcl|NW_020311354.1_prot_XP_025601845.1_5470 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311400.1_prot_XP_012264256.1_7396 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311436.1_prot_XP_012258223.1_8783 3 MetaCyc: PWY-6596;Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6 "Adenosine nucleotides degradation I";"Purine salvage";"Purine metabolism" lcl|NW_020311940.1_prot_XP_012265589.1_11223 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311973.1_prot_XP_025602689.1_16363 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311333.1_prot_XP_012256071.1_4295 4 Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination" lcl|NW_020311970.1_prot_XP_012260236.1_15605 33 Reactome: R-HSA-9648025;Reactome: R-HSA-165054;Reactome: R-HSA-180910;Reactome: R-HSA-68877;Reactome: R-HSA-6784531;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-159231;Reactome: R-HSA-5663220;Reactome: R-HSA-1169408;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-168271;Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-168325;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-2467813;Reactome: R-HSA-191859;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "EML4 and NUDC in mitotic spindle formation";"Rev-mediated nuclear export of HIV RNA";"Vpr-mediated nuclear import of PICs";"Mitotic Prometaphase";"tRNA processing in the nucleus";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"RHO GTPases Activate Formins";"ISG15 antiviral mechanism";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Viral Messenger RNA Synthesis";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Separation of Sister Chromatids";"snRNP Assembly";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" lcl|NW_020311469.1_prot_XP_012266619.1_9299 1 Reactome: R-HSA-2028269 "Signaling by Hippo" lcl|NW_020311978.1_prot_XP_020708587.1_18355 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311980.1_prot_XP_012261250.1_18844 2 Reactome: R-HSA-8876198;Reactome: R-HSA-204005 "RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport" lcl|NW_020311292.1_prot_XP_012252465.1_525 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311956.1_prot_XP_020706566.1_12640 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311959.1_prot_XP_020710104.1_13115 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311935.1_prot_XP_020711612.1_10912 4 MetaCyc: PWY-5912;MetaCyc: PWY-5041;Reactome: R-HSA-156581;KEGG: 00270+2.5.1.6 "2'-deoxymugineic acid phytosiderophore biosynthesis";"S-adenosyl-L-methionine cycle II";"Methylation";"Cysteine and methionine metabolism" lcl|NW_020311375.1_prot_XP_012256321.1_6547 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" lcl|NW_020311296.1_prot_XP_012265420.1_1006 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311389.1_prot_XP_025601959.1_7000 7 KEGG: 00240+2.4.2.10;MetaCyc: PWY-7791;KEGG: 00983+2.4.2.10;MetaCyc: PWY-5686;KEGG: 00240+4.1.1.23;MetaCyc: PWY-7790;Reactome: R-HSA-500753 "Pyrimidine metabolism";"UMP biosynthesis III";"Drug metabolism - other enzymes";"UMP biosynthesis I";"Pyrimidine metabolism";"UMP biosynthesis II";"Pyrimidine biosynthesis" lcl|NW_020311286.1_prot_XP_020708394.1_223 5 KEGG: 00052+2.7.1.6;KEGG: 00520+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6527;MetaCyc: PWY-6317 "Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"D-galactose detoxification";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)" lcl|NW_020311323.1_prot_XP_020712044.1_3456 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311372.1_prot_XP_020712130.1_6377 9 Reactome: R-HSA-2173788;Reactome: R-HSA-5689603;Reactome: R-HSA-2173791;Reactome: R-HSA-3645790;Reactome: R-HSA-3656535;Reactome: R-HSA-3304356;Reactome: R-HSA-2173789;Reactome: R-HSA-3656532;Reactome: R-HSA-3642279 "Downregulation of TGF-beta receptor signaling";"UCH proteinases";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGFBR2 Kinase Domain Mutants in Cancer";"TGFBR1 LBD Mutants in Cancer";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGF-beta receptor signaling activates SMADs";"TGFBR1 KD Mutants in Cancer";"TGFBR2 MSI Frameshift Mutants in Cancer" lcl|NW_020311417.1_prot_XP_012259081.1_7949 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311401.1_prot_XP_012254962.1_7612 3 KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029;MetaCyc: PWY-7221 "Purine metabolism";"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311424.1_prot_XP_012255441.1_8181 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311311.1_prot_XP_012250806.1_2494 1 KEGG: 00900+3.4.24.84 "Terpenoid backbone biosynthesis" lcl|NW_020311432.1_prot_XP_012268808.1_8373 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311410.1_prot_XP_012269694.1_7834 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311298.1_prot_XP_012250560.1_1130 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311988.1_prot_XP_025602936.1_20533 1 MetaCyc: PWY-7799 "Arg/N-end rule pathway (eukaryotic)" lcl|NW_020311984.1_prot_XP_020707543.1_20069 6 Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-68949 "Switching of origins to a post-replicative state";"Unwinding of DNA";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin" lcl|NW_020311401.1_prot_XP_012255362.1_7525 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311974.1_prot_XP_020709334.1_16716 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311365.1_prot_XP_012259959.1_5964 4 Reactome: R-HSA-2129379;Reactome: R-HSA-216083;Reactome: R-HSA-3000170;Reactome: R-HSA-3000178 "Molecules associated with elastic fibres";"Integrin cell surface interactions";"Syndecan interactions";"ECM proteoglycans" lcl|NW_020311329.1_prot_XP_020706138.1_3967 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311290.1_prot_XP_020706974.1_439 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311953.1_prot_XP_012260667.1_12322 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311292.1_prot_XP_012262809.1_703 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311393.1_prot_XP_012265787.1_7197 2 Reactome: R-HSA-4086398;Reactome: R-HSA-418457 "Ca2+ pathway";"cGMP effects" lcl|NW_020311984.1_prot_XP_012254486.1_19926 11 Reactome: R-HSA-389948;Reactome: R-HSA-909733;Reactome: R-HSA-512988;Reactome: R-HSA-877312;Reactome: R-HSA-912694;Reactome: R-HSA-114604;Reactome: R-HSA-391160;Reactome: R-HSA-432142;Reactome: R-HSA-9008059;Reactome: R-HSA-210990;Reactome: R-HSA-388841 "PD-1 signaling";"Interferon alpha/beta signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of IFNG signaling";"Regulation of IFNA signaling";"GPVI-mediated activation cascade";"Signal regulatory protein family interactions";"Platelet sensitization by LDL";"Interleukin-37 signaling";"PECAM1 interactions";"Costimulation by the CD28 family" lcl|NW_020311966.1_prot_XP_012256328.1_14927 4 Reactome: R-HSA-72086;Reactome: R-HSA-77075;Reactome: R-HSA-167160;MetaCyc: PWY-7375 "mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Mrna capping I" lcl|NW_020311988.1_prot_XP_012261192.1_20712 2 Reactome: R-HSA-163841;KEGG: 00900+2.1.1.100 "Gamma carboxylation, hypusine formation and arylsulfatase activation";"Terpenoid backbone biosynthesis" lcl|NW_020311346.1_prot_XP_020710305.1_4956 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311320.1_prot_XP_012268079.1_3396 4 Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066 "RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" lcl|NW_020311958.1_prot_XP_012255657.1_12938 1 Reactome: R-HSA-5368286 "Mitochondrial translation initiation" lcl|NW_020311313.1_prot_XP_020709884.1_2848 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311966.1_prot_XP_012252945.1_14425 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311958.1_prot_XP_012255625.1_12935 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311974.1_prot_XP_020709425.1_16645 6 Reactome: R-HSA-210500;Reactome: R-HSA-181430;Reactome: R-HSA-181429;Reactome: R-HSA-388844;Reactome: R-HSA-264642;Reactome: R-HSA-212676 "Glutamate Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle" lcl|NW_020311966.1_prot_XP_012256749.1_15082 7 MetaCyc: PWY-882;KEGG: 00520+5.4.2.8;MetaCyc: PWY-7586;MetaCyc: PWY-5659;MetaCyc: PWY-7456;Reactome: R-HSA-446205;KEGG: 00051+5.4.2.8 "L-ascorbate biosynthesis I (L-galactose pathway)";"Amino sugar and nucleotide sugar metabolism";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"GDP-mannose biosynthesis";"Beta-(1,4)-mannan degradation";"Synthesis of GDP-mannose";"Fructose and mannose metabolism" lcl|NW_020311347.1_prot_XP_012266210.1_5075 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311432.1_prot_XP_012268672.1_8387 1 Reactome: R-HSA-373753 "Nephrin family interactions" lcl|NW_020311338.1_prot_XP_012263050.1_4578 13 Reactome: R-HSA-9646399;Reactome: R-HSA-382556;Reactome: R-HSA-8866654;Reactome: R-HSA-5689896;Reactome: R-HSA-110320;Reactome: R-HSA-6798695;Reactome: R-HSA-5689877;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-532668;Reactome: R-HSA-5358346;Reactome: R-HSA-8876725;Reactome: R-HSA-3371511 "Aggrephagy";"ABC-family proteins mediated transport";"E3 ubiquitin ligases ubiquitinate target proteins";"Ovarian tumor domain proteases";"Translesion Synthesis by POLH";"Neutrophil degranulation";"Josephin domain DUBs";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Hedgehog ligand biogenesis";"Protein methylation";"HSF1 activation" lcl|NW_020311317.1_prot_XP_012251851.1_3244 6 MetaCyc: PWY-7391;KEGG: 00900+2.7.1.36;Reactome: R-HSA-191273;Reactome: R-HSA-2426168;MetaCyc: PWY-6174;MetaCyc: PWY-922 "Isoprene biosynthesis II (engineered)";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Mevalonate pathway II (archaea)";"Mevalonate pathway I" lcl|NW_020311972.1_prot_XP_012267866.1_16258 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" lcl|NW_020311965.1_prot_XP_012259841.1_14050 32 Reactome: R-HSA-6796648;Reactome: R-HSA-167242;Reactome: R-HSA-6807505;Reactome: R-HSA-112382;Reactome: R-HSA-167158;Reactome: R-HSA-76042;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-168325;Reactome: R-HSA-9018519;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167162;Reactome: R-HSA-167238;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-77075;Reactome: R-HSA-72165;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-8851708;Reactome: R-HSA-167172;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-72086;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-75955 "TP53 Regulates Transcription of DNA Repair Genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA polymerase II transcribes snRNA genes";"Formation of RNA Pol II elongation complex";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"Viral Messenger RNA Synthesis";"Estrogen-dependent gene expression";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"RNA Polymerase II HIV Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Signaling by FGFR2 IIIa TM";"Transcription of the HIV genome";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"mRNA Capping";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Elongation" lcl|NW_020311364.1_prot_XP_012258858.1_5931 9 Reactome: R-HSA-9630222;Reactome: R-HSA-110357;Reactome: R-HSA-9630221;Reactome: R-HSA-110331;Reactome: R-HSA-110328;Reactome: R-HSA-110329;Reactome: R-HSA-9608287;Reactome: R-HSA-110330;Reactome: R-HSA-9608290 "Defective NTHL1 substrate binding";"Displacement of DNA glycosylase by APEX1";"Defective NTHL1 substrate processing";"Cleavage of the damaged purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged pyrimidine";"Defective MUTYH substrate binding";"Recognition and association of DNA glycosylase with site containing an affected purine";"Defective MUTYH substrate processing" lcl|NW_020311977.1_prot_XP_012263847.1_17742 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" lcl|NW_020311350.1_prot_XP_020706618.1_5344 6 Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311373.1_prot_XP_012266706.1_6465 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311365.1_prot_XP_012269339.1_6000 4 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription" lcl|NW_020311323.1_prot_XP_012267988.1_3459 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311401.1_prot_XP_012254954.1_7595 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311298.1_prot_XP_012269909.1_1381 13 Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557 "Formation of a pool of free 40S subunits";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis" lcl|NW_020311971.1_prot_XP_012263536.1_16084 12 Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids" lcl|NW_020311970.1_prot_XP_012267424.1_15805 6 Reactome: R-HSA-1655829;Reactome: R-HSA-381426;Reactome: R-HSA-381033;Reactome: R-HSA-8963889;Reactome: R-HSA-8957275;Reactome: R-HSA-8874211 "Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"ATF6 (ATF6-alpha) activates chaperones";"Assembly of active LPL and LIPC lipase complexes";"Post-translational protein phosphorylation";"CREB3 factors activate genes" lcl|NW_020311436.1_prot_XP_012258221.1_8782 3 Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596 "Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I" lcl|NW_020311975.1_prot_XP_012250983.1_17165 6 Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-156827 "Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression" lcl|NW_020311397.1_prot_XP_012258203.1_7282 3 Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-936837 "Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Ion transport by P-type ATPases" lcl|NW_020311965.1_prot_XP_012259401.1_14328 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311499.1_prot_XP_012269266.1_9558 1 KEGG: 00051+4.2.1.68 "Fructose and mannose metabolism" lcl|NW_020311342.1_prot_XP_012255780.1_4730 10 Reactome: R-HSA-2644606;Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2197563;Reactome: R-HSA-1912408;Reactome: R-HSA-350054;Reactome: R-HSA-8941856;Reactome: R-HSA-210744;Reactome: R-HSA-9013508 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"Pre-NOTCH Transcription and Translation";"Notch-HLH transcription pathway";"RUNX3 regulates NOTCH signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH3 Intracellular Domain Regulates Transcription" lcl|NW_020311983.1_prot_XP_020707884.1_19796 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311940.1_prot_XP_020711268.1_11343 3 KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3 "Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis" lcl|NW_020311945.1_prot_XP_012269647.1_11804 8 Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-912446;Reactome: R-HSA-5693579;Reactome: R-HSA-8953750;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554 "HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic recombination";"Homologous DNA Pairing and Strand Exchange";"Transcriptional Regulation by E2F6";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" lcl|NW_020311329.1_prot_XP_012269542.1_4005 6 Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311368.1_prot_XP_012264430.1_6214 4 Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311362.1_prot_XP_020710998.1_5875 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311397.1_prot_XP_012258195.1_7297 3 Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311993.1_prot_XP_012262696.1_21340 2 KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710 "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311410.1_prot_XP_025602002.1_7827 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311422.1_prot_XP_020707474.1_8140 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311943.1_prot_XP_020707699.1_11652 5 MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-6902;Reactome: R-HSA-189085 "Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Digestion of dietary carbohydrate" lcl|NW_020311297.1_prot_XP_020707428.1_1084 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311306.1_prot_XP_012264225.1_2098 4 MetaCyc: PWY-6823;KEGG: 00790+4.1.99.22;KEGG: 00790+4.6.1.17;Reactome: R-HSA-947581 "Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis" lcl|NW_020311967.1_prot_XP_025602606.1_15256 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311303.1_prot_XP_012264562.1_1716 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311388.1_prot_XP_012262195.1_6951 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311367.1_prot_XP_012258948.1_6073 3 Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-429947 "ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Deadenylation of mRNA" lcl|NW_020311513.1_prot_XP_020711460.1_9869 4 Reactome: R-HSA-8849175;Reactome: R-HSA-5358493;MetaCyc: PWY-7546;MetaCyc: PWY-6482 "Threonine catabolism";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)" lcl|NW_020311289.1_prot_XP_012253985.1_384 27 Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-3371453;Reactome: R-HSA-168271;Reactome: R-HSA-5619107;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-159227;Reactome: R-HSA-3301854;Reactome: R-HSA-180746;Reactome: R-HSA-3232142;Reactome: R-HSA-4615885;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-9609690;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-180910;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-5578749;Reactome: R-HSA-168276 "SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Regulation of HSF1-mediated heat shock response";"Transport of Ribonucleoproteins into the Host Nucleus";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA replication proteins";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"HCMV Early Events";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"Vpr-mediated nuclear import of PICs";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways" lcl|NW_020311980.1_prot_XP_012255739.1_18920 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311461.1_prot_XP_012269175.1_9207 3 Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-6783310 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Fanconi Anemia Pathway" lcl|NW_020311306.1_prot_XP_020710756.1_2049 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311334.1_prot_XP_025601754.1_4343 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311969.1_prot_XP_012264790.1_15546 1 Reactome: R-HSA-191859 "snRNP Assembly" lcl|NW_020311995.1_prot_XP_020708170.1_22066 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311424.1_prot_XP_012255448.1_8189 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311539.1_prot_XP_012262355.1_9992 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311528.1_prot_XP_012258494.1_9965 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311326.1_prot_XP_012261520.1_3720 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311934.1_prot_XP_012255368.1_10851 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311365.1_prot_XP_012260305.1_5940 1 Reactome: R-HSA-71288 "Creatine metabolism" lcl|NW_020311324.1_prot_XP_012269361.1_3566 5 MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;Reactome: R-HSA-189085 "Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Digestion of dietary carbohydrate" lcl|NW_020311425.1_prot_XP_012265060.1_8243 3 Reactome: R-HSA-202427;Reactome: R-HSA-6798695;Reactome: R-HSA-6807004 "Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation";"Negative regulation of MET activity" lcl|NW_020311992.1_prot_XP_012266497.1_21045 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" lcl|NW_020311980.1_prot_XP_012261310.1_18856 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311992.1_prot_XP_012266344.1_20988 2 Reactome: R-HSA-74217;KEGG: 00230+1.7.1.7 "Purine salvage";"Purine metabolism" lcl|NW_020311432.1_prot_XP_012268797.1_8509 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" lcl|NW_020311965.1_prot_XP_012260273.1_14161 1 Reactome: R-HSA-71262 "Carnitine synthesis" lcl|NW_020311417.1_prot_XP_025602028.1_7959 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" lcl|NW_020311380.1_prot_XP_012268219.1_6758 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" lcl|NW_020311590.1_prot_XP_012254410.1_10063 2 Reactome: R-HSA-446193;Reactome: R-HSA-4549349 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG2 causes ALG2-CDG (CDG-1i)" lcl|NW_020311981.1_prot_XP_012257557.1_19150 7 Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-73980 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination" lcl|NW_020311973.1_prot_XP_025602688.1_16366 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311426.1_prot_XP_012268524.1_8260 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311962.1_prot_XP_025602500.1_13658 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" lcl|NW_020311313.1_prot_XP_012261862.1_2901 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311984.1_prot_XP_012254438.1_19905 16 Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-156827 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression" lcl|NW_020311436.1_prot_XP_012258213.1_8775 3 KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596 "Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I" lcl|NW_020311296.1_prot_XP_020711157.1_995 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311983.1_prot_XP_020707870.1_19805 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311985.1_prot_XP_012265296.1_20189 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311318.1_prot_XP_012253501.1_3312 14 MetaCyc: PWY-6367;Reactome: R-HSA-434316;Reactome: R-HSA-418217;MetaCyc: PWY-8052;MetaCyc: PWY-6351;Reactome: R-HSA-112043;Reactome: R-HSA-500657;KEGG: 00562+3.1.4.11;Reactome: R-HSA-4086398;MetaCyc: PWY-7039;Reactome: R-HSA-416476;Reactome: R-HSA-399997;KEGG: 04070+3.1.4.11;Reactome: R-HSA-1855204 "D-myo-inositol-5-phosphate metabolism";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G beta:gamma signalling through PLC beta";"2-arachidonoylglycerol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"PLC beta mediated events";"Presynaptic function of Kainate receptors";"Inositol phosphate metabolism";"Ca2+ pathway";"Phosphatidate metabolism, as a signaling molecule";"G alpha (q) signalling events";"Acetylcholine regulates insulin secretion";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol" lcl|NW_020311300.1_prot_XP_012253162.1_1527 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311296.1_prot_XP_012265316.1_988 5 Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556 "Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes" lcl|NW_020311977.1_prot_XP_020710600.1_17963 11 Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-3214847;Reactome: R-HSA-6804756;Reactome: R-HSA-5689880;Reactome: R-HSA-167161;Reactome: R-HSA-73779;Reactome: R-HSA-76042 "RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"HATs acetylate histones";"Regulation of TP53 Activity through Phosphorylation";"Ub-specific processing proteases";"HIV Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance" lcl|NW_020311966.1_prot_XP_012256804.1_15198 4 MetaCyc: PWY-7887;Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+2.8.1.12 "Protein SAMPylation and SAMP-mediated thiolation";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis" lcl|NW_020311325.1_prot_XP_012251438.1_3681 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" lcl|NW_020311983.1_prot_XP_020707879.1_19791 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311984.1_prot_XP_012264696.2_19817 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311962.1_prot_XP_012251836.1_13734 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311368.1_prot_XP_020710819.1_6193 19 Reactome: R-HSA-3371571;Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-5673000;Reactome: R-HSA-6802952;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-111932;Reactome: R-HSA-9649948;Reactome: R-HSA-877300;Reactome: R-HSA-6802955;Reactome: R-HSA-442982;Reactome: R-HSA-438066;Reactome: R-HSA-399719;Reactome: R-HSA-9022692;Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001 "HSF1-dependent transactivation";"Ion transport by P-type ATPases";"Ion homeostasis";"RAF activation";"Signaling by BRAF and RAF fusions";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"CaMK IV-mediated phosphorylation of CREB";"Signaling downstream of RAS mutants";"Interferon gamma signaling";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ras activation upon Ca2+ influx through NMDA receptor";"Unblocking of NMDA receptors, glutamate binding and activation";"Trafficking of AMPA receptors";"Regulation of MECP2 expression and activity";"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade" lcl|NW_020311305.1_prot_XP_012251485.1_2033 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311324.1_prot_XP_020712512.1_3589 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311432.1_prot_XP_025602073.1_8557 2 Reactome: R-HSA-418594;Reactome: R-HSA-6814122 "G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" lcl|NW_020311980.1_prot_XP_012255761.1_18880 7 Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061 "RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" lcl|NW_020311943.1_prot_XP_012255254.1_11684 1 Reactome: R-HSA-6803204 "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" lcl|NW_020311377.1_prot_XP_012266628.1_6621 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311968.1_prot_XP_012253089.1_15431 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" lcl|NW_020311948.1_prot_XP_012253458.1_12098 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311939.1_prot_XP_012263617.1_11051 2 Reactome: R-HSA-983168;Reactome: R-HSA-110320 "Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH" lcl|NW_020311347.1_prot_XP_020711381.1_5038 10 Reactome: R-HSA-6798695;KEGG: 00052+3.2.1.23;Reactome: R-HSA-2160916;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2024096;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2206292;KEGG: 00600+3.2.1.23 "Neutrophil degranulation";"Galactose metabolism";"Hyaluronan uptake and degradation";"Other glycan degradation";"HS-GAG degradation";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"MPS VII - Sly syndrome";"Sphingolipid metabolism" lcl|NW_020311286.1_prot_XP_012256674.1_54 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311403.1_prot_XP_012258124.1_7727 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311977.1_prot_XP_012252244.1_17467 5 MetaCyc: PWY-6344;Reactome: R-HSA-8964539;MetaCyc: PWY-3341;MetaCyc: PWY-4981;KEGG: 00330+1.5.1.2 "L-ornithine degradation II (Stickland reaction)";"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)";"L-proline biosynthesis II (from arginine)";"Arginine and proline metabolism" lcl|NW_020311411.1_prot_XP_012254211.1_7839 6 Reactome: R-HSA-3299685;Reactome: R-HSA-9033241;Reactome: R-HSA-9615017;KEGG: 00630+1.11.1.6;Reactome: R-HSA-6798695;KEGG: 00380+1.11.1.6 "Detoxification of Reactive Oxygen Species";"Peroxisomal protein import";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Glyoxylate and dicarboxylate metabolism";"Neutrophil degranulation";"Tryptophan metabolism" lcl|NW_020311966.1_prot_XP_012256983.1_14732 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311940.1_prot_XP_020711227.1_11179 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311969.1_prot_XP_012264787.1_15541 1 Reactome: R-HSA-264876 "Insulin processing" lcl|NW_020311386.1_prot_XP_012268143.1_6916 10 MetaCyc: PWY-7524;MetaCyc: PWY-6174;Reactome: R-HSA-1989781;KEGG: 00900+2.3.3.10;MetaCyc: PWY-922;KEGG: 00650+2.3.3.10;KEGG: 00280+2.3.3.10;MetaCyc: PWY-7391;KEGG: 00072+2.3.3.10;MetaCyc: PWY-7571 "Mevalonate pathway III (archaea)";"Mevalonate pathway II (archaea)";"PPARA activates gene expression";"Terpenoid backbone biosynthesis";"Mevalonate pathway I";"Butanoate metabolism";"Valine, leucine and isoleucine degradation";"Isoprene biosynthesis II (engineered)";"Synthesis and degradation of ketone bodies";"Ferrichrome A biosynthesis" lcl|NW_020311976.1_prot_XP_012253643.1_17223 10 MetaCyc: PWY-7661;Reactome: R-HSA-4719360;MetaCyc: PWY-7921;Reactome: R-HSA-162699;Reactome: R-HSA-913709;KEGG: 00510+2.4.1.83;MetaCyc: PWY-7979;MetaCyc: PWY-7922;Reactome: R-HSA-4719377;Reactome: R-HSA-4717374 "Protein N-glycosylation (Haloferax volcanii)";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Protein O-mannosylation I (yeast)";"Synthesis of dolichyl-phosphate mannose";"O-linked glycosylation of mucins";"N-Glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM1 causes DPM1-CDG (CDG-1e)" lcl|NW_020311432.1_prot_XP_020712308.1_8390 1 Reactome: R-HSA-373753 "Nephrin family interactions" lcl|NW_020311432.1_prot_XP_012268719.1_8453 4 Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387 "Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling" lcl|NW_020311982.1_prot_XP_012258436.1_19268 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311973.1_prot_XP_012258795.1_16444 7 Reactome: R-HSA-204174;Reactome: R-HSA-70268;Reactome: R-HSA-389661;KEGG: 00010+2.3.1.12;KEGG: 00020+2.3.1.12;KEGG: 00620+2.3.1.12;Reactome: R-HSA-5362517 "Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)";"Pyruvate metabolism";"Signaling by Retinoic Acid" lcl|NW_020311965.1_prot_XP_012259500.1_14367 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311981.1_prot_XP_012257531.1_18998 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311325.1_prot_XP_012253376.1_3694 2 Reactome: R-HSA-6798695;Reactome: R-HSA-6811434 "Neutrophil degranulation";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311961.1_prot_XP_012262619.1_13532 5 Reactome: R-HSA-6804758;Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-427389 "Regulation of TP53 Activity through Acetylation";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" lcl|NW_020311975.1_prot_XP_012251026.1_17059 4 KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9;Reactome: R-HSA-196757;KEGG: 00670+1.5.1.6 "Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"Metabolism of folate and pterines";"One carbon pool by folate" lcl|NW_020311966.1_prot_XP_012251763.1_14598 4 KEGG: 00270+2.5.1.16;KEGG: 00330+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00480+2.5.1.16 "Cysteine and methionine metabolism";"Arginine and proline metabolism";"Metabolism of polyamines";"Glutathione metabolism" lcl|NW_020311432.1_prot_XP_020712306.1_8406 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311432.1_prot_XP_012268932.1_8514 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311326.1_prot_XP_012261529.1_3731 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311342.1_prot_XP_012255763.1_4752 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311973.1_prot_XP_020708831.1_16393 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311966.1_prot_XP_020708276.1_15126 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311327.1_prot_XP_012252846.1_3773 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311966.1_prot_XP_012256844.1_14988 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311397.1_prot_XP_012258205.1_7302 3 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases" lcl|NW_020311917.1_prot_XP_012250981.1_10246 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311953.1_prot_XP_012260510.1_12244 6 Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107 "Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism" lcl|NW_020311367.1_prot_XP_012258949.1_6087 2 Reactome: R-HSA-2393930;MetaCyc: PWY-6502 "Phosphate bond hydrolysis by NUDT proteins";"8-oxo-(d)GTP detoxification I" lcl|NW_020311994.1_prot_XP_012267551.1_21801 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311298.1_prot_XP_012269863.1_1314 5 Reactome: R-HSA-5674400;Reactome: R-HSA-3371571;Reactome: R-HSA-166208;Reactome: R-HSA-198323;Reactome: R-HSA-165159 "Constitutive Signaling by AKT1 E17K in Cancer";"HSF1-dependent transactivation";"mTORC1-mediated signalling";"AKT phosphorylates targets in the cytosol";"mTOR signalling" lcl|NW_020311943.1_prot_XP_012255152.1_11642 3 KEGG: 00250+3.5.1.1;KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693 "Alanine, aspartate and glutamate metabolism";"Cyanoamino acid metabolism";"Aspartate and asparagine metabolism" lcl|NW_020311403.1_prot_XP_025601998.1_7735 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311941.1_prot_XP_012253133.1_11426 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311324.1_prot_XP_012269462.1_3559 5 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-6784531 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"tRNA processing in the nucleus" lcl|NW_020311408.1_prot_XP_012262130.1_7819 1 MetaCyc: PWY-7942 "5-oxo-L-proline metabolism" lcl|NW_020311958.1_prot_XP_012260385.1_12900 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311355.1_prot_XP_020706980.1_5500 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311970.1_prot_XP_012256552.1_15719 3 Reactome: R-HSA-5628897;Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "TP53 Regulates Metabolic Genes";"Detoxification of Reactive Oxygen Species";"Glutathione metabolism" lcl|NW_020311983.1_prot_XP_012255622.1_19729 2 Reactome: R-HSA-4641265;Reactome: R-HSA-5339700 "Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP" lcl|NW_020311433.1_prot_XP_012263836.1_8625 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311970.1_prot_XP_012260180.1_15582 2 Reactome: R-HSA-8854518;Reactome: R-HSA-6804756 "AURKA Activation by TPX2";"Regulation of TP53 Activity through Phosphorylation" lcl|NW_020311977.1_prot_XP_012253844.1_17568 14 MetaCyc: PWY-5695;KEGG: 00983+1.17.3.2;MetaCyc: PWY-6607;MetaCyc: PWY-6596;KEGG: 00230+1.17.1.4;MetaCyc: PWY-5497;KEGG: 00230+1.17.1.4+1.17.3.2;Reactome: R-HSA-8851680;MetaCyc: PWY-6538;Reactome: R-HSA-74259;KEGG: 00232+1.17.3.2;MetaCyc: PWY-6608;MetaCyc: PWY-6606;MetaCyc: PWY-6999 "Inosine 5'-phosphate degradation";"Drug metabolism - other enzymes";"Guanosine nucleotides degradation I";"Adenosine nucleotides degradation I";"Purine metabolism";"Purine nucleobases degradation II (anaerobic)";"Purine metabolism";"Butyrophilin (BTN) family interactions";"Caffeine degradation III (bacteria, via demethylation)";"Purine catabolism";"Caffeine metabolism";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Theophylline degradation" lcl|NW_020311974.1_prot_XP_012260264.1_16768 2 Reactome: R-HSA-1566948;Reactome: R-HSA-2243919 "Elastic fibre formation";"Crosslinking of collagen fibrils" lcl|NW_020311305.1_prot_XP_012264131.1_2005 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311977.1_prot_XP_012263702.1_18012 1 Reactome: R-HSA-525793 "Myogenesis" lcl|NW_020311962.1_prot_XP_025602501.1_13659 2 MetaCyc: PWY-6854;Reactome: R-HSA-3299685 "Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species" lcl|NW_020311940.1_prot_XP_012265566.1_11191 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311966.1_prot_XP_012257247.1_14863 2 Reactome: R-HSA-427413;Reactome: R-HSA-3214847 "NoRC negatively regulates rRNA expression";"HATs acetylate histones" lcl|NW_020311960.1_prot_XP_012254159.1_13231 5 MetaCyc: PWY-6317;MetaCyc: PWY-6527;MetaCyc: PWY-3821;KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6 "D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"D-galactose detoxification";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism" lcl|NW_020311917.1_prot_XP_012250974.1_10257 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311959.1_prot_XP_020707484.1_13206 1 Reactome: R-HSA-525793 "Myogenesis" lcl|NW_020311994.1_prot_XP_012262170.1_21822 1 Reactome: R-HSA-5676934 "Protein repair" lcl|NW_020311977.1_prot_XP_012264094.1_17855 6 Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656 "Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311982.1_prot_XP_020708739.1_19259 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311286.1_prot_XP_025602636.1_144 6 KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;Reactome: R-HSA-114508 "Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Effects of PIP2 hydrolysis" lcl|NW_020311299.1_prot_XP_012267801.1_1404 14 MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-7036;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-7725;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-8041 "Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis" lcl|NW_020311992.1_prot_XP_012266504.1_21015 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311988.1_prot_XP_020709725.1_20696 3 Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081 "Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling" lcl|NW_020311990.1_prot_XP_012266615.1_20839 2 KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336 "Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway" lcl|NW_020311974.1_prot_XP_012260019.1_16659 3 MetaCyc: PWY-6100;Reactome: R-HSA-71262;KEGG: 00310+1.14.11.8 "L-carnitine biosynthesis";"Carnitine synthesis";"Lysine degradation" lcl|NW_020311298.1_prot_XP_012250494.1_1307 1 Reactome: R-HSA-191859 "snRNP Assembly" lcl|NW_020311917.1_prot_XP_012250973.1_10255 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311992.1_prot_XP_012266428.1_21223 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311356.1_prot_XP_012267078.1_5572 1 Reactome: R-HSA-163560 "Triglyceride catabolism" lcl|NW_020311494.1_prot_XP_012261244.1_9493 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311513.1_prot_XP_012266187.1_9891 6 Reactome: R-HSA-4793952;KEGG: 00510+2.4.1.143;KEGG: 00513+2.4.1.143;Reactome: R-HSA-975578;MetaCyc: PWY-7920;MetaCyc: PWY-7426 "Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (plants)";"Complex N-linked glycan biosynthesis (vertebrates)" lcl|NW_020311362.1_prot_XP_012264951.1_5866 22 MetaCyc: PWY-7619;MetaCyc: PWY-7049;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-6598;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-7727;MetaCyc: PWY-7726;Reactome: R-HSA-75876;MetaCyc: PWY-7728;KEGG: 00062+4.2.1.134;MetaCyc: PWY-6958;MetaCyc: PWY-5353;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-7035;MetaCyc: PWY-7592;MetaCyc: PWY-7606;MetaCyc: PWY-7053;MetaCyc: PWY-7601 "Juniperonate biosynthesis";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Synthesis of very long-chain fatty acyl-CoAs";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Fatty acid elongation";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)" lcl|NW_020311983.1_prot_XP_012267216.1_19502 2 KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600 "Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" lcl|NW_020311419.1_prot_XP_012254059.1_8075 1 Reactome: R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" lcl|NW_020311983.1_prot_XP_020707885.1_19798 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311322.1_prot_XP_012267976.1_3444 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" lcl|NW_020311971.1_prot_XP_012263520.1_16068 13 Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553 "Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311359.1_prot_XP_012252065.1_5717 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311354.1_prot_XP_012260704.1_5474 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311380.1_prot_XP_020709814.1_6683 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311441.1_prot_XP_020706505.1_8901 1 Reactome: R-HSA-2564830 "Cytosolic iron-sulfur cluster assembly" lcl|NW_020311306.1_prot_XP_012264248.1_2066 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" lcl|NW_020311321.1_prot_XP_020710419.1_3411 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311971.1_prot_XP_012260836.1_15902 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" lcl|NW_020311327.1_prot_XP_012252864.1_3785 56 Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-1236978;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902 "Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"G2/M Checkpoints";"Regulation of RAS by GAPs";"Cross-presentation of soluble exogenous antigens (endosomes)";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Ub-specific processing proteases";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity" lcl|NW_020311347.1_prot_XP_012266158.1_5067 7 Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476 "RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311976.1_prot_XP_012257240.1_17415 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311942.1_prot_XP_012252454.1_11459 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" lcl|NW_020311325.1_prot_XP_025603097.1_3662 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311430.1_prot_XP_012253305.2_8291 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311975.1_prot_XP_012253057.1_17079 9 Reactome: R-HSA-4420097;Reactome: R-HSA-2871809;Reactome: R-HSA-5218920;Reactome: R-HSA-2029482;Reactome: R-HSA-2871796;Reactome: R-HSA-416482;Reactome: R-HSA-114604;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "VEGFA-VEGFR2 Pathway";"FCERI mediated Ca+2 mobilization";"VEGFR2 mediated vascular permeability";"Regulation of actin dynamics for phagocytic cup formation";"FCERI mediated MAPK activation";"G alpha (12/13) signalling events";"GPVI-mediated activation cascade";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311959.1_prot_XP_012262390.1_13076 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" lcl|NW_020311988.1_prot_XP_012269363.1_20487 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311976.1_prot_XP_012253598.1_17214 3 KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160;Reactome: R-HSA-4420097 "T cell receptor signaling pathway";"Signal regulatory protein family interactions";"VEGFA-VEGFR2 Pathway" lcl|NW_020311962.1_prot_XP_012251888.1_13602 3 Reactome: R-HSA-450513;Reactome: R-HSA-430039;Reactome: R-HSA-450385 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" lcl|NW_020311978.1_prot_XP_020708668.1_18121 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311961.1_prot_XP_020710184.1_13428 1 Reactome: R-HSA-9033241 "Peroxisomal protein import" lcl|NW_020311973.1_prot_XP_020708833.1_16395 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311441.1_prot_XP_012251248.1_8894 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311995.1_prot_XP_020708153.1_21928 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311925.1_prot_XP_012265828.1_10569 1 Reactome: R-HSA-176974 "Unwinding of DNA" lcl|NW_020311329.1_prot_XP_020706137.1_3969 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311954.1_prot_XP_012268173.1_12336 2 Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13 "RHO GTPases activate PKNs";"Phosphatidylinositol signaling system" lcl|NW_020311993.1_prot_XP_012268384.1_21475 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311298.1_prot_XP_020706299.1_1306 1 Reactome: R-HSA-191859 "snRNP Assembly" lcl|NW_020311973.1_prot_XP_012258574.1_16345 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311327.1_prot_XP_020706971.1_3787 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311970.1_prot_XP_012259967.1_15586 4 Reactome: R-HSA-446203;Reactome: R-HSA-1799339;Reactome: R-HSA-879415;Reactome: R-HSA-6798695 "Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane";"Advanced glycosylation endproduct receptor signaling";"Neutrophil degranulation" lcl|NW_020311308.1_prot_XP_012253334.1_2227 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311315.1_prot_XP_012265293.1_3116 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311513.1_prot_XP_012266121.1_9840 4 MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943 "Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates" lcl|NW_020311424.1_prot_XP_020707852.1_8218 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" lcl|NW_020311962.1_prot_XP_012251930.1_13822 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311977.1_prot_XP_012263777.1_17704 6 Reactome: R-HSA-3371599;KEGG: 00785+2.3.1.181;KEGG: 00780+6.3.4.15;Reactome: R-HSA-196780;MetaCyc: PWY-7382;MetaCyc: PWY-6987 "Defective HLCS causes multiple carboxylase deficiency";"Lipoic acid metabolism";"Biotin metabolism";"Biotin transport and metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoate biosynthesis and incorporation III (Bacillus)" lcl|NW_020311961.1_prot_XP_020710225.1_13510 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311398.1_prot_XP_025601988.1_7371 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311967.1_prot_XP_012256133.1_15260 3 Reactome: R-HSA-8868766;Reactome: R-HSA-6787450;Reactome: R-HSA-6785470 "rRNA processing in the mitochondrion";"tRNA modification in the mitochondrion";"tRNA processing in the mitochondrion" lcl|NW_020311978.1_prot_XP_020708567.1_18065 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311959.1_prot_XP_012262382.1_13122 2 KEGG: 00280+1.1.1.31;Reactome: R-HSA-70895 "Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism" lcl|NW_020311947.1_prot_XP_012260651.1_11953 1 Reactome: R-HSA-429958 "mRNA decay by 3' to 5' exoribonuclease" lcl|NW_020311332.1_prot_XP_020712188.1_4127 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311971.1_prot_XP_012260953.1_15925 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311975.1_prot_XP_012251945.1_17042 1 Reactome: R-HSA-433137 "Sodium-coupled sulphate, di- and tri-carboxylate transporters" lcl|NW_020311309.1_prot_XP_020709039.1_2349 3 Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing" lcl|NW_020311294.1_prot_XP_012264897.1_895 15 Reactome: R-HSA-5693568;Reactome: R-HSA-912446;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-5693579;Reactome: R-HSA-2559586;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5685939;Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-5693548;Reactome: R-HSA-5693616 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic recombination";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"Homologous DNA Pairing and Strand Exchange";"DNA Damage/Telomere Stress Induced Senescence";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"HDR through MMEJ (alt-NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Sensing of DNA Double Strand Breaks";"Presynaptic phase of homologous DNA pairing and strand exchange" lcl|NW_020311984.1_prot_XP_012254470.1_19973 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311980.1_prot_XP_012261297.1_18786 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311994.1_prot_XP_025602992.1_21570 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.2 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311973.1_prot_XP_020708876.1_16335 1 Reactome: R-HSA-72203 "Processing of Capped Intron-Containing Pre-mRNA" lcl|NW_020311312.1_prot_XP_012266790.1_2598 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311966.1_prot_XP_012256380.1_14960 7 Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025 "Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311983.1_prot_XP_012268325.1_19553 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311932.1_prot_XP_012257418.1_10714 6 Reactome: R-HSA-1855183;Reactome: R-HSA-1855204;KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368;KEGG: 00562+3.1.3.36;Reactome: R-HSA-194840 "Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Inositol phosphate metabolism";"Rho GTPase cycle" lcl|NW_020311364.1_prot_XP_020708951.1_5926 6 Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025 "RHO GTPases Activate Formins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311965.1_prot_XP_012260253.1_14131 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311976.1_prot_XP_012257033.1_17397 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311971.1_prot_XP_012263575.1_16007 1 Reactome: R-HSA-8876725 "Protein methylation" lcl|NW_020311448.1_prot_XP_020706926.1_9005 1 Reactome: R-HSA-977347 "Serine biosynthesis" lcl|NW_020311983.1_prot_XP_020711769.1_19493 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" lcl|NW_020311338.1_prot_XP_012263072.1_4537 4 Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664 "DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation" lcl|NW_020311990.1_prot_XP_020711514.1_20827 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311300.1_prot_XP_012253113.1_1593 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311969.1_prot_XP_020710978.1_15545 2 Reactome: R-HSA-9010553;Reactome: R-HSA-975957 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311925.1_prot_XP_012258460.1_10517 7 Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066 "Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" lcl|NW_020311969.1_prot_XP_012264768.1_15560 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311289.1_prot_XP_012253823.1_365 9 MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5744;Reactome: R-HSA-1475029;MetaCyc: PWY-7115;MetaCyc: PWY-241;MetaCyc: PWY-7117 "3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"Glyoxylate assimilation";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type" lcl|NW_020311347.1_prot_XP_012266209.1_5074 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311433.1_prot_XP_012263840.1_8652 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" lcl|NW_020311994.1_prot_XP_012267385.1_21710 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311966.1_prot_XP_012256391.1_14948 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311983.1_prot_XP_012255535.1_19649 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" lcl|NW_020311977.1_prot_XP_020706775.1_17465 5 MetaCyc: PWY-6344;Reactome: R-HSA-8964539;KEGG: 00330+1.5.1.2;MetaCyc: PWY-4981;MetaCyc: PWY-3341 "L-ornithine degradation II (Stickland reaction)";"Glutamate and glutamine metabolism";"Arginine and proline metabolism";"L-proline biosynthesis II (from arginine)";"L-proline biosynthesis III (from L-ornithine)" lcl|NW_020311298.1_prot_XP_012269912.1_1281 2 Reactome: R-HSA-3214815;Reactome: R-HSA-427413 "HDACs deacetylate histones";"NoRC negatively regulates rRNA expression" lcl|NW_020311315.1_prot_XP_012265202.1_3129 2 Reactome: R-HSA-1483191;Reactome: R-HSA-425366 "Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds" lcl|NW_020311959.1_prot_XP_012262441.1_13135 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311974.1_prot_XP_012260299.1_16893 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311436.1_prot_XP_012258215.1_8777 3 MetaCyc: PWY-6596;KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217 "Adenosine nucleotides degradation I";"Purine metabolism";"Purine salvage" lcl|NW_020311988.1_prot_XP_012260678.1_20558 5 Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084 "Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism";"Lysine degradation";"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA" lcl|NW_020311418.1_prot_XP_012260991.1_7970 7 Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-380270 "AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311956.1_prot_XP_012251354.1_12645 1 Reactome: R-HSA-211897 "Cytochrome P450 - arranged by substrate type" lcl|NW_020311360.1_prot_XP_012251632.1_5747 5 MetaCyc: PWY-5532;Reactome: R-HSA-73614;Reactome: R-HSA-73621;KEGG: 00983+2.4.2.3;KEGG: 00240+2.4.2.3 "Nucleoside and nucleotide degradation (archaea)";"Pyrimidine salvage";"Pyrimidine catabolism";"Drug metabolism - other enzymes";"Pyrimidine metabolism" lcl|NW_020311988.1_prot_XP_020707696.1_20590 1 Reactome: R-HSA-2514853 "Condensation of Prometaphase Chromosomes" lcl|NW_020311994.1_prot_XP_020711881.1_21600 4 KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541;Reactome: R-HSA-499943;MetaCyc: PWY-7221 "Purine metabolism";"Abacavir metabolism";"Interconversion of nucleotide di- and triphosphates";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311329.1_prot_XP_012258974.1_3942 4 Reactome: R-HSA-1912420;Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Pre-NOTCH Processing in Golgi";"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311955.1_prot_XP_020711173.1_12405 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311995.1_prot_XP_012256252.1_22030 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" lcl|NW_020311313.1_prot_XP_020709931.1_2836 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311993.1_prot_XP_012263259.1_21350 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311961.1_prot_XP_012262585.1_13409 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311970.1_prot_XP_025602641.1_15702 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311962.1_prot_XP_012252115.1_13831 3 Reactome: R-HSA-5632928;Reactome: R-HSA-5358565;Reactome: R-HSA-5632968 "Defective Mismatch Repair Associated With MSH2";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH6" lcl|NW_020311286.1_prot_XP_012256556.1_156 13 KEGG: 00720+4.2.1.2;MetaCyc: PWY-561;MetaCyc: PWY-5392;MetaCyc: PWY-6728;MetaCyc: PWY-5690;MetaCyc: PWY-7254;MetaCyc: PWY-6969;KEGG: 00020+4.2.1.2;MetaCyc: PWY-5913;KEGG: 00620+4.2.1.2;MetaCyc: PWY-7384;Reactome: R-HSA-71403;MetaCyc: PWY-8086 "Carbon fixation pathways in prokaryotes";"Superpathway of glyoxylate cycle and fatty acid degradation";"Reductive TCA cycle II";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"TCA cycle VII (acetate-producers)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Pyruvate metabolism";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citric acid cycle (TCA cycle)";"(S)-lactate fermentation to propanoate, acetate and hydrogen" lcl|NW_020311981.1_prot_XP_012257446.1_18944 14 Reactome: R-HSA-196757;MetaCyc: PWY-1622;KEGG: 00680+2.1.2.1;MetaCyc: PWY-3841;MetaCyc: PWY-3661-1;MetaCyc: PWY-5497;MetaCyc: PWY-3661;KEGG: 00630+2.1.2.1;KEGG: 00460+2.1.2.1;MetaCyc: PWY-2201;MetaCyc: PWY-2161;KEGG: 00670+2.1.2.1;KEGG: 00260+2.1.2.1;MetaCyc: PWY-181 "Metabolism of folate and pterines";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Folate transformations II (plants)";"Glycine betaine degradation II (mammalian)";"Purine nucleobases degradation II (anaerobic)";"Glycine betaine degradation I";"Glyoxylate and dicarboxylate metabolism";"Cyanoamino acid metabolism";"Folate transformations I";"Folate polyglutamylation";"One carbon pool by folate";"Glycine, serine and threonine metabolism";"Photorespiration " lcl|NW_020311966.1_prot_XP_020708231.1_14750 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311329.1_prot_XP_012269610.1_3996 1 Reactome: R-HSA-196836 "Vitamin C (ascorbate) metabolism" lcl|NW_020311513.1_prot_XP_020711415.1_9826 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311362.1_prot_XP_012264953.1_5868 22 MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6958;MetaCyc: PWY-5353;MetaCyc: PWY-7053;MetaCyc: PWY-7606;MetaCyc: PWY-7601;MetaCyc: PWY-7592;MetaCyc: PWY-7035;MetaCyc: PWY-5080;MetaCyc: PWY-7049;MetaCyc: PWY-7619;Reactome: R-HSA-75876;MetaCyc: PWY-7727;MetaCyc: PWY-7724;MetaCyc: PWY-7726;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7728;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-6598;MetaCyc: PWY-6433 "Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid elongation";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)" lcl|NW_020311374.1_prot_XP_012264661.1_6530 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311946.1_prot_XP_012268826.1_11945 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311987.1_prot_XP_012251896.1_20452 5 Reactome: R-HSA-380994;Reactome: R-HSA-9614657;Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-381183 "ATF4 activates genes in response to endoplasmic reticulum stress";"FOXO-mediated transcription of cell death genes";"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"ATF6 (ATF6-alpha) activates chaperone genes" lcl|NW_020311934.1_prot_XP_012255030.1_10828 1 Reactome: R-HSA-5389840 "Mitochondrial translation elongation" lcl|NW_020311970.1_prot_XP_012267508.1_15788 13 Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557 "Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis" lcl|NW_020311397.1_prot_XP_012253756.1_7353 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311983.1_prot_XP_012267176.1_19530 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311962.1_prot_XP_020706713.1_13823 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311298.1_prot_XP_012250521.1_1364 3 Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-3108214 "DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"SUMOylation of DNA damage response and repair proteins" lcl|NW_020311308.1_prot_XP_025603034.1_2168 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" lcl|NW_020311311.1_prot_XP_012250757.1_2543 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311975.1_prot_XP_020707568.1_17034 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311983.1_prot_XP_012267208.1_19486 4 Reactome: R-HSA-3000178;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081 "ECM proteoglycans";"Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling" lcl|NW_020311983.1_prot_XP_012268301.1_19597 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311946.1_prot_XP_012268866.1_11874 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311975.1_prot_XP_012252963.1_16961 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311423.1_prot_XP_012251562.1_8163 6 MetaCyc: PWY-622;MetaCyc: PWY-7900;KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085 "Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate" lcl|NW_020311959.1_prot_XP_012254249.1_13198 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" lcl|NW_020311980.1_prot_XP_012261294.1_18789 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311962.1_prot_XP_012251862.1_13711 3 Reactome: R-HSA-1483213;KEGG: 00564+4.1.1.65;MetaCyc: PWY-5669 "Synthesis of PE";"Glycerophospholipid metabolism";"Phosphatidylserine and phosphatidylethanolamine biosynthesis I" lcl|NW_020311961.1_prot_XP_012262625.1_13302 1 Reactome: R-HSA-1483166 "Synthesis of PA" lcl|NW_020311970.1_prot_XP_012267433.1_15809 5 Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-77387 "Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Insulin receptor recycling" lcl|NW_020311327.1_prot_XP_012263456.1_3871 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311333.1_prot_XP_012255897.1_4301 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311971.1_prot_XP_012263627.1_16135 4 Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295 "COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation" lcl|NW_020311356.1_prot_XP_012267054.1_5570 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311943.1_prot_XP_020707704.1_11637 3 KEGG: 00250+3.5.1.1;KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693 "Alanine, aspartate and glutamate metabolism";"Cyanoamino acid metabolism";"Aspartate and asparagine metabolism" lcl|NW_020311308.1_prot_XP_020710836.1_2180 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311981.1_prot_XP_020708430.1_19015 4 Reactome: R-HSA-2173788;Reactome: R-HSA-2173789;Reactome: R-HSA-3656532;Reactome: R-HSA-3304356 "Downregulation of TGF-beta receptor signaling";"TGF-beta receptor signaling activates SMADs";"TGFBR1 KD Mutants in Cancer";"SMAD2/3 Phosphorylation Motif Mutants in Cancer" lcl|NW_020311962.1_prot_XP_012252071.1_13691 1 Reactome: R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" lcl|NW_020311919.1_prot_XP_012257633.1_10476 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" lcl|NW_020311961.1_prot_XP_020710180.1_13525 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311985.1_prot_XP_012265154.1_20207 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" lcl|NW_020311337.1_prot_XP_012251810.1_4445 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311977.1_prot_XP_020710730.1_17869 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311992.1_prot_XP_012266313.1_21102 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311982.1_prot_XP_012258422.1_19190 7 Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-1362300;Reactome: R-HSA-1538133;Reactome: R-HSA-156711;Reactome: R-HSA-69656 "G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G0 and Early G1";"Polo-like kinase mediated events";"Cyclin A:Cdk2-associated events at S phase entry" lcl|NW_020311423.1_prot_XP_012251563.1_8164 6 MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085;MetaCyc: PWY-622;MetaCyc: PWY-7900;KEGG: 00500+2.4.1.18 "Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate";"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism" lcl|NW_020311992.1_prot_XP_020711562.1_20989 2 KEGG: 00230+1.7.1.7;Reactome: R-HSA-74217 "Purine metabolism";"Purine salvage" lcl|NW_020311980.1_prot_XP_020709793.1_18853 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311967.1_prot_XP_012254338.1_15341 1 Reactome: R-HSA-70350 "Fructose catabolism" lcl|NW_020311991.1_prot_XP_020706216.1_20944 6 Reactome: R-HSA-5685939;Reactome: R-HSA-110362;Reactome: R-HSA-174437;Reactome: R-HSA-69166;Reactome: R-HSA-162594;Reactome: R-HSA-5651801 "HDR through MMEJ (alt-NHEJ)";"POLB-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate from the C-strand";"Removal of the Flap Intermediate";"Early Phase of HIV Life Cycle";"PCNA-Dependent Long Patch Base Excision Repair" lcl|NW_020311348.1_prot_XP_012269849.1_5107 11 Reactome: R-HSA-9664565;Reactome: R-HSA-1250196;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993;Reactome: R-HSA-5673001;Reactome: R-HSA-1963642;Reactome: R-HSA-1227986;Reactome: R-HSA-8863795;Reactome: R-HSA-6785631;Reactome: R-HSA-6811558;Reactome: R-HSA-2219530 "Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB2 signaling";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling";"RAF/MAP kinase cascade";"PI3K events in ERBB2 signaling";"Signaling by ERBB2";"Downregulation of ERBB2 signaling";"ERBB2 Regulates Cell Motility";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Constitutive Signaling by Aberrant PI3K in Cancer" lcl|NW_020311329.1_prot_XP_020706139.1_3968 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311402.1_prot_XP_012267026.1_7710 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311313.1_prot_XP_020709934.1_2840 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311919.1_prot_XP_012257630.1_10491 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" lcl|NW_020311962.1_prot_XP_020706711.1_13819 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" lcl|NW_020311981.1_prot_XP_012257535.1_19042 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311948.1_prot_XP_020707182.1_12035 1 Reactome: R-HSA-2468052 "Establishment of Sister Chromatid Cohesion" lcl|NW_020311978.1_prot_XP_012257991.1_18069 1 KEGG: 00480+3.4.11.1 "Glutathione metabolism" lcl|NW_020311940.1_prot_XP_012265588.1_11222 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311286.1_prot_XP_012256886.1_149 7 Reactome: R-HSA-2470946;Reactome: R-HSA-2500257;Reactome: R-HSA-9018519;Reactome: R-HSA-1221632;Reactome: R-HSA-3108214;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052 "Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion";"Estrogen-dependent gene expression";"Meiotic synapsis";"SUMOylation of DNA damage response and repair proteins";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion" lcl|NW_020311388.1_prot_XP_025601955.1_6991 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311973.1_prot_XP_012258660.1_16582 7 Reactome: R-HSA-5083628;Reactome: R-HSA-5083633;Reactome: R-HSA-3000171;Reactome: R-HSA-5083629;Reactome: R-HSA-3000178;Reactome: R-HSA-9010553;Reactome: R-HSA-5173105 "Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Non-integrin membrane-ECM interactions";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"ECM proteoglycans";"Regulation of expression of SLITs and ROBOs";"O-linked glycosylation" lcl|NW_020311976.1_prot_XP_012257160.1_17392 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311309.1_prot_XP_020709025.1_2317 2 KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7 "Pyruvate metabolism";"Aminobenzoate degradation" lcl|NW_020311995.1_prot_XP_012256784.1_21907 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311320.1_prot_XP_012267628.1_3388 2 MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10 "CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311977.1_prot_XP_012264059.1_17852 6 KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656 "Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311972.1_prot_XP_012267857.1_16268 2 Reactome: R-HSA-2564830;Reactome: R-HSA-5693554 "Cytosolic iron-sulfur cluster assembly";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" lcl|NW_020311978.1_prot_XP_020708582.1_18057 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311978.1_prot_XP_020708590.1_18358 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311424.1_prot_XP_012255415.1_8201 2 Reactome: R-HSA-379716;Reactome: R-HSA-2408522 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism" lcl|NW_020311968.1_prot_XP_020707043.1_15444 2 Reactome: R-HSA-1296072;Reactome: R-HSA-5576894 "Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels" lcl|NW_020311966.1_prot_XP_020708237.1_14729 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311475.1_prot_XP_012253318.1_9396 16 Reactome: R-HSA-1660499;Reactome: R-HSA-1433557;Reactome: R-HSA-1257604;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558;Reactome: R-HSA-389357;Reactome: R-HSA-416476;Reactome: R-HSA-512988;Reactome: R-HSA-912631;Reactome: R-HSA-8853659;Reactome: R-HSA-912526;Reactome: R-HSA-114604;Reactome: R-HSA-194840;Reactome: R-HSA-9009391;Reactome: R-HSA-388841;Reactome: R-HSA-1266695 "Synthesis of PIPs at the plasma membrane";"Signaling by SCF-KIT";"PIP3 activates AKT signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"CD28 dependent PI3K/Akt signaling";"G alpha (q) signalling events";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of signaling by CBL";"RET signaling";"Interleukin receptor SHC signaling";"GPVI-mediated activation cascade";"Rho GTPase cycle";"Extra-nuclear estrogen signaling";"Costimulation by the CD28 family";"Interleukin-7 signaling" lcl|NW_020311992.1_prot_XP_012266561.1_21192 4 Reactome: R-HSA-69205;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-176187 "G1/S-Specific Transcription";"Activation of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress" lcl|NW_020311448.1_prot_XP_020706924.1_9006 1 Reactome: R-HSA-977347 "Serine biosynthesis" lcl|NW_020311974.1_prot_XP_012260279.1_16706 7 MetaCyc: PWY-5484;KEGG: 00030+3.1.3.11;KEGG: 00051+3.1.3.11;Reactome: R-HSA-70263;KEGG: 00680+3.1.3.11;KEGG: 00010+3.1.3.11;KEGG: 00710+3.1.3.11 "Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Fructose and mannose metabolism";"Gluconeogenesis";"Methane metabolism";"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms" lcl|NW_020311940.1_prot_XP_012265515.1_11288 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" lcl|NW_020311298.1_prot_XP_020706280.1_1211 3 Reactome: R-HSA-392154;Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2 "Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction";"Purine metabolism" lcl|NW_020311973.1_prot_XP_025602698.1_16570 1 Reactome: R-HSA-186797 "Signaling by PDGF" lcl|NW_020311962.1_prot_XP_012251927.1_13820 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" lcl|NW_020311986.1_prot_XP_012258849.1_20337 7 Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-2660826 "NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant" lcl|NW_020311290.1_prot_XP_025601786.1_444 1 Reactome: R-HSA-8964038 "LDL clearance" lcl|NW_020311962.1_prot_XP_012252114.1_13832 3 Reactome: R-HSA-5632968;Reactome: R-HSA-5358565;Reactome: R-HSA-5632928 "Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH2" lcl|NW_020311987.1_prot_XP_012256588.1_20375 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" lcl|NW_020311991.1_prot_XP_012269777.1_20872 4 Reactome: R-HSA-70688;KEGG: 00330+1.5.5.2;MetaCyc: PWY-6922;MetaCyc: PWY-5737 "Proline catabolism";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis";"(5R)-carbapenem carboxylate biosynthesis" lcl|NW_020311286.1_prot_XP_012256438.1_225 5 MetaCyc: PWY-6527;MetaCyc: PWY-6317;KEGG: 00052+2.7.1.6;KEGG: 00520+2.7.1.6;MetaCyc: PWY-3821 "Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"D-galactose detoxification" lcl|NW_020311974.1_prot_XP_020709389.1_16924 2 Reactome: R-HSA-416993;Reactome: R-HSA-202733 "Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall" lcl|NW_020311993.1_prot_XP_012262947.1_21378 3 Reactome: R-HSA-2022928;MetaCyc: PWY-6558;KEGG: 00534+5.1.3.17 "HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin" lcl|NW_020311308.1_prot_XP_020710840.1_2178 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311977.1_prot_XP_012264108.1_18005 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311513.1_prot_XP_012266082.1_9876 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311407.1_prot_XP_020707769.1_7770 20 MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7337;MetaCyc: PWY-7291;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7858;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-6920;MetaCyc: PWY-7288;MetaCyc: PWY-7007;Reactome: R-HSA-9033241;MetaCyc: PWY-735;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7574;MetaCyc: PWY-7854;MetaCyc: PWY-7606 "Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"alpha-Linolenic acid metabolism";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"beta-Alanine metabolism";"(5Z)-dodecenoate biosynthesis II";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Methyl ketone biosynthesis (engineered)";"Peroxisomal protein import";"Jasmonic acid biosynthesis";"Propanoate metabolism";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoyl-coa degradation II";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)" lcl|NW_020311619.1_prot_XP_020709573.1_10077 2 Reactome: R-HSA-2029482;Reactome: R-HSA-5663213 "Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs" lcl|NW_020311992.1_prot_XP_012260884.1_20960 1 Reactome: R-HSA-3295583 "TRP channels" lcl|NW_020311513.1_prot_XP_012265958.1_9717 1 Reactome: R-HSA-2142789 "Ubiquinol biosynthesis" lcl|NW_020311925.1_prot_XP_020711310.1_10568 1 Reactome: R-HSA-176974 "Unwinding of DNA" lcl|NW_020311979.1_prot_XP_012259516.1_18526 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311329.1_prot_XP_020706134.1_3965 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311919.1_prot_XP_020708517.1_10474 4 KEGG: 00970+6.1.1.10;KEGG: 00450+6.1.1.10;Reactome: R-HSA-379716;Reactome: R-HSA-2408522 "Aminoacyl-tRNA biosynthesis";"Selenocompound metabolism";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism" lcl|NW_020311423.1_prot_XP_020706612.1_8158 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311973.1_prot_XP_012258722.1_16634 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311982.1_prot_XP_012258242.1_19249 11 KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-171007;KEGG: 05165+2.7.11.1;Reactome: R-HSA-450302;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-2559580;Reactome: R-HSA-4420097 "Thermogenesis";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"p38MAPK events";"Human papillomavirus infection";"activated TAK1 mediates p38 MAPK activation";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Oxidative Stress Induced Senescence";"VEGFA-VEGFR2 Pathway" lcl|NW_020311333.1_prot_XP_012256067.1_4292 4 Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311312.1_prot_XP_020711710.1_2777 7 KEGG: 00562+2.7.8.11;MetaCyc: PWY-7625;KEGG: 04070+2.7.8.11;KEGG: 00564+2.7.8.11;MetaCyc: PWY-6351;Reactome: R-HSA-1483226;MetaCyc: PWY-6352 "Inositol phosphate metabolism";"Phosphatidylinositol biosynthesis II (eukaryotes)";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of PI";"3-phosphoinositide biosynthesis" lcl|NW_020311981.1_prot_XP_012257559.1_19133 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311983.1_prot_XP_012268329.1_19559 7 Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476 "RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311380.1_prot_XP_012268218.1_6709 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311322.1_prot_XP_012267982.1_3446 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" lcl|NW_020311971.1_prot_XP_012263566.1_16033 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311975.1_prot_XP_012253065.1_17078 9 Reactome: R-HSA-2871809;Reactome: R-HSA-4420097;Reactome: R-HSA-5218920;Reactome: R-HSA-2029482;Reactome: R-HSA-2871796;Reactome: R-HSA-114604;Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "FCERI mediated Ca+2 mobilization";"VEGFA-VEGFR2 Pathway";"VEGFR2 mediated vascular permeability";"Regulation of actin dynamics for phagocytic cup formation";"FCERI mediated MAPK activation";"GPVI-mediated activation cascade";"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" lcl|NW_020311391.1_prot_XP_020706601.1_7045 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311395.1_prot_XP_012260731.1_7227 7 Reactome: R-HSA-165054;Reactome: R-HSA-203927;Reactome: R-HSA-1655829;Reactome: R-HSA-180746;Reactome: R-HSA-168333;Reactome: R-HSA-5578749;Reactome: R-HSA-6784531 "Rev-mediated nuclear export of HIV RNA";"MicroRNA (miRNA) biogenesis";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Nuclear import of Rev protein";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transcriptional regulation by small RNAs";"tRNA processing in the nucleus" lcl|NW_020311401.1_prot_XP_020707764.1_7540 22 Reactome: R-HSA-9648025;Reactome: R-HSA-5467340;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-68877;Reactome: R-HSA-432142;Reactome: R-HSA-5673000;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-5358752;Reactome: R-HSA-6811558;Reactome: R-HSA-5663220;Reactome: R-HSA-5467348;Reactome: R-HSA-5358747;Reactome: R-HSA-195253;Reactome: R-HSA-5675221;Reactome: R-HSA-4641262;Reactome: R-HSA-196299;Reactome: R-HSA-5358751;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "EML4 and NUDC in mitotic spindle formation";"AXIN missense mutants destabilize the destruction complex";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Platelet sensitization by LDL";"RAF activation";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"T41 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RHO GTPases Activate Formins";"Truncations of AMER1 destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"Negative regulation of MAPK pathway";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Beta-catenin phosphorylation cascade";"S45 mutants of beta-catenin aren't phosphorylated";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" lcl|NW_020311964.1_prot_XP_025602513.1_13868 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311988.1_prot_XP_012261202.1_20674 5 Reactome: R-HSA-977347;KEGG: 00680+1.1.1.95;KEGG: 00270+1.1.1.95;KEGG: 00260+1.1.1.95;MetaCyc: PWY-8010 "Serine biosynthesis";"Methane metabolism";"Cysteine and methionine metabolism";"Glycine, serine and threonine metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)" lcl|NW_020311477.1_prot_XP_012262229.1_9432 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311974.1_prot_XP_020709329.1_16709 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311918.1_prot_XP_020710279.1_10300 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" lcl|NW_020311977.1_prot_XP_012263676.1_17792 17 MetaCyc: PWY-6679;MetaCyc: PWY-4381;Reactome: R-HSA-196780;KEGG: 00640+6.4.1.2;KEGG: 00254+6.4.1.2;Reactome: R-HSA-2426168;Reactome: R-HSA-200425;Reactome: R-HSA-163765;Reactome: R-HSA-3371599;MetaCyc: PWY-5966-1;KEGG: 00720+6.4.1.2;MetaCyc: PWY-5744;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6722;KEGG: 00620+6.4.1.2;MetaCyc: PWY-5743;MetaCyc: PWY-5789 "Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Biotin transport and metabolism";"Propanoate metabolism";"Aflatoxin biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Carnitine metabolism";"ChREBP activates metabolic gene expression";"Defective HLCS causes multiple carboxylase deficiency";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Carbon fixation pathways in prokaryotes";"Glyoxylate assimilation";"Fatty acid biosynthesis";"Candicidin biosynthesis";"Pyruvate metabolism";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle" lcl|NW_020311961.1_prot_XP_012262516.1_13320 2 KEGG: 00970+6.1.1.7;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" lcl|NW_020311917.1_prot_XP_020706446.1_10211 1 Reactome: R-HSA-380320 "Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311356.1_prot_XP_012267079.1_5573 1 Reactome: R-HSA-163560 "Triglyceride catabolism" lcl|NW_020311977.1_prot_XP_012263999.1_17659 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311993.1_prot_XP_012262112.1_21423 6 Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-9010553;Reactome: R-HSA-975957 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311298.1_prot_XP_012250571.1_1271 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311961.1_prot_XP_012262536.1_13413 1 Reactome: R-HSA-9603798 "Class I peroxisomal membrane protein import" lcl|NW_020311943.1_prot_XP_012254873.2_11536 9 KEGG: 00052+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.25;KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23;Reactome: R-HSA-8853383 "Galactose metabolism";"Neutrophil degranulation";"Other glycan degradation";"Glycosaminoglycan degradation";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Lysosomal oligosaccharide catabolism" lcl|NW_020311985.1_prot_XP_012265236.1_20198 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311957.1_prot_XP_025602440.1_12674 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" lcl|NW_020311292.1_prot_XP_012252538.1_672 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" lcl|NW_020311979.1_prot_XP_012259408.1_18551 20 Reactome: R-HSA-5693607;Reactome: R-HSA-110312;Reactome: R-HSA-5696400;Reactome: R-HSA-6804756;Reactome: R-HSA-110320;Reactome: R-HSA-5696397;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-69473;Reactome: R-HSA-5685942;Reactome: R-HSA-174411;Reactome: R-HSA-5656121;Reactome: R-HSA-5685938;Reactome: R-HSA-69091;Reactome: R-HSA-110314;Reactome: R-HSA-5693616;Reactome: R-HSA-176187;Reactome: R-HSA-5655862;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135 "Processing of DNA double-strand break ends";"Translesion synthesis by REV1";"Dual Incision in GG-NER";"Regulation of TP53 Activity through Phosphorylation";"Translesion Synthesis by POLH";"Gap-filling DNA repair synthesis and ligation in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"G2/M DNA damage checkpoint";"HDR through Homologous Recombination (HRR)";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by POLI";"HDR through Single Strand Annealing (SSA)";"Polymerase switching";"Recognition of DNA damage by PCNA-containing replication complex";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER" lcl|NW_020311324.1_prot_XP_012269431.1_3582 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311984.1_prot_XP_012267656.1_20182 6 Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-69052 "Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Unwinding of DNA";"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state" lcl|NW_020311365.1_prot_XP_012269333.1_5993 4 Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862 "NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants" lcl|NW_020311513.1_prot_XP_012266152.1_9830 6 KEGG: 00564+1.1.5.3;Reactome: R-HSA-163560;MetaCyc: PWY-4261;Reactome: R-HSA-1483166;MetaCyc: PWY-6118;MetaCyc: PWY-6952 "Glycerophospholipid metabolism";"Triglyceride catabolism";"Glycerol degradation I";"Synthesis of PA";"Glycerol-3-phosphate shuttle";"Glycerophosphodiester degradation" lcl|NW_020311984.1_prot_XP_020707592.1_20057 2 Reactome: R-HSA-6814122;Reactome: R-HSA-418594 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events" lcl|NW_020311978.1_prot_XP_012257874.1_18377 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311977.1_prot_XP_012253853.1_17572 22 Reactome: R-HSA-6798695;MetaCyc: PWY-621;MetaCyc: PWY-7385;Reactome: R-HSA-5628897;MetaCyc: PWY-3801;KEGG: 00520+5.3.1.9;KEGG: 00010+5.3.1.9;KEGG: 00500+5.3.1.9;MetaCyc: PWY-5054;MetaCyc: PWY-5659;Reactome: R-HSA-70171;MetaCyc: PWY-5514;MetaCyc: PWY-6981;MetaCyc: PWY-5384;MetaCyc: PWY-622;MetaCyc: PWY-6142;MetaCyc: PWY-7238;Reactome: R-HSA-70263;KEGG: 00030+5.3.1.9;MetaCyc: PWY-8013;MetaCyc: PWY-7347;MetaCyc: PWY-6992 "Neutrophil degranulation";"Sucrose degradation III (sucrose invertase)";"1,3-propanediol biosynthesis (engineered)";"TP53 Regulates Metabolic Genes";"Sucrose degradation II (sucrose synthase)";"Amino sugar and nucleotide sugar metabolism";"Glycolysis / Gluconeogenesis";"Starch and sucrose metabolism";"D-sorbitol biosynthesis I";"GDP-mannose biosynthesis";"Glycolysis";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Chitin biosynthesis";"Sucrose degradation IV (sucrose phosphorylase)";"Starch biosynthesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Sucrose biosynthesis II";"Gluconeogenesis";"Pentose phosphate pathway";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Sucrose biosynthesis III";"1,5-anhydrofructose degradation" lcl|NW_020311929.1_prot_XP_012268022.1_10669 2 Reactome: R-HSA-382556;Reactome: R-HSA-5678895 "ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis" lcl|NW_020311965.1_prot_XP_020709421.1_14213 4 KEGG: 00970+2.9.1.2;KEGG: 00450+2.9.1.2;Reactome: R-HSA-2408557;MetaCyc: PWY-6281 "Aminoacyl-tRNA biosynthesis";"Selenocompound metabolism";"Selenocysteine synthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)" lcl|NW_020311973.1_prot_XP_020708899.1_16604 20 KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724;Reactome: R-HSA-380972;Reactome: R-HSA-165159;KEGG: 05170+2.7.11.1;Reactome: R-HSA-1632852;Reactome: R-HSA-3371571;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;KEGG: 04714+2.7.11.1;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;KEGG: 04150+2.7.11.1 "Human papillomavirus infection";"PI3K-Akt signaling pathway";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"Relaxin signaling pathway";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Human immunodeficiency virus 1 infection";"Macroautophagy";"HSF1-dependent transactivation";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"Thermogenesis";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"mTOR signaling pathway" lcl|NW_020311972.1_prot_XP_012267844.1_16253 10 Reactome: R-HSA-69473;Reactome: R-HSA-5693568;Reactome: R-HSA-5693607;Reactome: R-HSA-5693579;Reactome: R-HSA-3108214;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616 "G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Processing of DNA double-strand break ends";"Homologous DNA Pairing and Strand Exchange";"SUMOylation of DNA damage response and repair proteins";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange" lcl|NW_020311980.1_prot_XP_012261305.1_18860 4 KEGG: 00250+1.4.1.14;Reactome: R-HSA-73621;KEGG: 00910+1.4.1.14;MetaCyc: PWY-6963 "Alanine, aspartate and glutamate metabolism";"Pyrimidine catabolism";"Nitrogen metabolism";"Ammonia assimilation cycle I" lcl|NW_020311958.1_prot_XP_012255695.1_12963 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311940.1_prot_XP_020711269.1_11345 3 KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3 "Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis" lcl|NW_020311968.1_prot_XP_012265683.1_15465 2 MetaCyc: PWY-6829;Reactome: R-HSA-6782315 "Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol" lcl|NW_020311994.1_prot_XP_012267467.1_21794 2 KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753 "Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism" lcl|NW_020311332.1_prot_XP_012256284.1_4147 2 MetaCyc: PWY-7851;KEGG: 00770+2.7.1.24 "Coenzyme A biosynthesis II (eukaryotic)";"Pantothenate and CoA biosynthesis" lcl|NW_020311380.1_prot_XP_012261407.1_6691 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311977.1_prot_XP_012263922.1_17862 6 KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656 "Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311985.1_prot_XP_012253908.1_20290 2 Reactome: R-HSA-8964539;Reactome: R-HSA-2151201 "Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311973.1_prot_XP_012258658.1_16455 2 Reactome: R-HSA-373080;Reactome: R-HSA-3238698 "Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking" lcl|NW_020311396.1_prot_XP_020706140.1_7258 3 Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-8876198 "Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311980.1_prot_XP_012261360.2_18873 2 Reactome: R-HSA-8949664;Reactome: R-HSA-8949215 "Processing of SMDT1";"Mitochondrial calcium ion transport" lcl|NW_020311314.1_prot_XP_020706758.1_3071 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311956.1_prot_XP_012254452.1_12574 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311450.1_prot_XP_012260325.1_9038 17 Reactome: R-HSA-5696400;Reactome: R-HSA-174417;Reactome: R-HSA-5358565;Reactome: R-HSA-69166;Reactome: R-HSA-5696397;Reactome: R-HSA-174414;Reactome: R-HSA-174411;Reactome: R-HSA-5685942;Reactome: R-HSA-69183;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801;Reactome: R-HSA-174437;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-110314;Reactome: R-HSA-5358606;Reactome: R-HSA-69091 "Dual Incision in GG-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Removal of the Flap Intermediate";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Processive synthesis on the C-strand of the telomere";"Polymerase switching on the C-strand of the telomere";"HDR through Homologous Recombination (HRR)";"Processive synthesis on the lagging strand";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate from the C-strand";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Polymerase switching" lcl|NW_020311438.1_prot_XP_012269007.1_8812 4 Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2470946;Reactome: R-HSA-2500257 "Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion" lcl|NW_020311324.1_prot_XP_012269366.1_3570 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311513.1_prot_XP_020711461.1_9867 4 MetaCyc: PWY-6482;MetaCyc: PWY-7546;Reactome: R-HSA-5358493;Reactome: R-HSA-8849175 "Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)";"Synthesis of diphthamide-EEF2";"Threonine catabolism" lcl|NW_020311981.1_prot_XP_012257434.1_18949 8 Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-8948747;Reactome: R-HSA-5689880;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-8866652;Reactome: R-HSA-6804757 "Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Regulation of PTEN localization";"Ub-specific processing proteases";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Regulation of TP53 Degradation" lcl|NW_020311978.1_prot_XP_012257818.1_18056 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311472.1_prot_XP_020712447.1_9308 9 Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-6807505;Reactome: R-HSA-167161 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA polymerase II transcribes snRNA genes";"HIV Transcription Initiation" lcl|NW_020311312.1_prot_XP_012266809.1_2664 3 Reactome: R-HSA-975574;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.144 "Reactions specific to the hybrid N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis" lcl|NW_020311324.1_prot_XP_012269360.1_3565 5 MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-6902;Reactome: R-HSA-189085 "Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Digestion of dietary carbohydrate" lcl|NW_020311992.1_prot_XP_012266358.1_21139 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311353.1_prot_XP_020708031.1_5399 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311988.1_prot_XP_020709707.1_20715 6 Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-450513 "mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" lcl|NW_020311513.1_prot_XP_012266189.1_9893 6 Reactome: R-HSA-975578;MetaCyc: PWY-7920;MetaCyc: PWY-7426;Reactome: R-HSA-4793952;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143 "Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (plants)";"Complex N-linked glycan biosynthesis (vertebrates)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis" lcl|NW_020311404.1_prot_XP_012262736.1_7747 1 Reactome: R-HSA-176974 "Unwinding of DNA" lcl|NW_020311961.1_prot_XP_020710185.1_13429 1 Reactome: R-HSA-9033241 "Peroxisomal protein import" lcl|NW_020311995.1_prot_XP_012256662.1_22055 2 KEGG: 00071+2.3.1.21;MetaCyc: PWY-6111 "Fatty acid degradation";"Mitochondrial L-carnitine shuttle" lcl|NW_020311983.1_prot_XP_012255552.1_19735 2 Reactome: R-HSA-5689896;Reactome: R-HSA-195253 "Ovarian tumor domain proteases";"Degradation of beta-catenin by the destruction complex" lcl|NW_020311962.1_prot_XP_012251889.1_13603 3 Reactome: R-HSA-450385;Reactome: R-HSA-430039;Reactome: R-HSA-450513 "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" lcl|NW_020311432.1_prot_XP_012268789.1_8480 6 Reactome: R-HSA-434316;Reactome: R-HSA-456926;Reactome: R-HSA-418592;Reactome: R-HSA-416476;Reactome: R-HSA-399997;Reactome: R-HSA-428930 "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"ADP signalling through P2Y purinoceptor 1";"G alpha (q) signalling events";"Acetylcholine regulates insulin secretion";"Thromboxane signalling through TP receptor" lcl|NW_020311957.1_prot_XP_012263295.1_12830 13 Reactome: R-HSA-2022857;MetaCyc: PWY-6902;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7883;Reactome: R-HSA-2160916;Reactome: R-HSA-1660662;KEGG: 00513+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52 "Keratan sulfate degradation";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"CS/DS degradation";"Glycosphingolipid biosynthesis - ganglio series";"Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation";"Glycosphingolipid metabolism";"Various types of N-glycan biosynthesis";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series" lcl|NW_020311969.1_prot_XP_020710961.1_15555 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311994.1_prot_XP_012267484.1_21742 5 MetaCyc: PWY-7268;MetaCyc: PWY-5083;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7269 "NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)" lcl|NW_020311292.1_prot_XP_020706819.1_670 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" lcl|NW_020311441.1_prot_XP_020706511.1_8886 3 Reactome: R-HSA-189451;MetaCyc: PWY-7159;KEGG: 00860+1.3.3.4 "Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism" lcl|NW_020311982.1_prot_XP_012258359.1_19319 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311438.1_prot_XP_012269010.1_8811 5 Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-5689901 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Metalloprotease DUBs" lcl|NW_020311973.1_prot_XP_012258773.1_16403 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311957.1_prot_XP_012263338.1_12784 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311978.1_prot_XP_012257778.1_18384 2 Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198 "Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis" lcl|NW_020311286.1_prot_XP_012256885.1_147 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311539.1_prot_XP_012262216.1_10017 3 Reactome: R-HSA-110330;Reactome: R-HSA-110357;Reactome: R-HSA-110331 "Recognition and association of DNA glycosylase with site containing an affected purine";"Displacement of DNA glycosylase by APEX1";"Cleavage of the damaged purine" lcl|NW_020311988.1_prot_XP_012267179.1_20619 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311943.1_prot_XP_020707841.1_11577 1 Reactome: R-HSA-196819 "Vitamin B1 (thiamin) metabolism" lcl|NW_020311994.1_prot_XP_025602989.1_21834 13 Reactome: R-HSA-2160916;MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2024101;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;MetaCyc: PWY-6902;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-1660662 "Hyaluronan uptake and degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series";"CS/DS degradation";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Various types of N-glycan biosynthesis";"Glycosphingolipid metabolism" lcl|NW_020311397.1_prot_XP_012253730.1_7340 3 KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261;Reactome: R-HSA-75109 "Glycerolipid metabolism";"Glycerol degradation I";"Triglyceride biosynthesis" lcl|NW_020311329.1_prot_XP_012258971.1_3940 4 Reactome: R-HSA-936837;Reactome: R-HSA-1912420;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Pre-NOTCH Processing in Golgi";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" lcl|NW_020311982.1_prot_XP_020708767.1_19215 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" lcl|NW_020311982.1_prot_XP_012258255.1_19219 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311946.1_prot_XP_012268748.1_11899 8 KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00051+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00524+2.7.1.1 "Starch and sucrose metabolism";"Streptomycin biosynthesis";"Glycolysis";"Fructose and mannose metabolism";"Galactose metabolism";"Glycolysis / Gluconeogenesis";"Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis" lcl|NW_020311966.1_prot_XP_020708234.1_14749 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311985.1_prot_XP_012265252.1_20212 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311316.1_prot_XP_012269014.1_3168 1 Reactome: R-HSA-420029 "Tight junction interactions" lcl|NW_020311955.1_prot_XP_012265359.1_12466 24 Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-190861;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-3371497;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-5617833;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-437239;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-8955332;Reactome: R-HSA-380320;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399 "COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Gap junction assembly";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Kinesins";"Resolution of Sister Chromatid Cohesion";"Cilium Assembly";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Recycling pathway of L1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"HCMV Early Events";"RHO GTPases Activate Formins";"Carboxyterminal post-translational modifications of tubulin";"Recruitment of NuMA to mitotic centrosomes";"Separation of Sister Chromatids";"Aggrephagy" lcl|NW_020311315.1_prot_XP_012265276.1_3105 19 Reactome: R-HSA-5687128;Reactome: R-HSA-525793;Reactome: R-HSA-8964616;Reactome: R-HSA-5627123;Reactome: R-HSA-983231;Reactome: R-HSA-5625970;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-182971;Reactome: R-HSA-5663220;Reactome: R-HSA-428543;Reactome: R-HSA-4420097;Reactome: R-HSA-3928662;Reactome: R-HSA-389359;Reactome: R-HSA-5663213;Reactome: R-HSA-5626467;Reactome: R-HSA-418885;Reactome: R-HSA-8950505;Reactome: R-HSA-2029482 "MAPK6/MAPK4 signaling";"Myogenesis";"G beta:gamma signalling through CDC42";"RHO GTPases activate PAKs";"Factors involved in megakaryocyte development and platelet production";"RHO GTPases activate KTN1";"Rho GTPase cycle";"GPVI-mediated activation cascade";"EGFR downregulation";"RHO GTPases Activate Formins";"Inactivation of CDC42 and RAC1";"VEGFA-VEGFR2 Pathway";"EPHB-mediated forward signaling";"CD28 dependent Vav1 pathway";"RHO GTPases Activate WASPs and WAVEs";"RHO GTPases activate IQGAPs";"DCC mediated attractive signaling";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Regulation of actin dynamics for phagocytic cup formation" lcl|NW_020311995.1_prot_XP_012256975.2_21989 5 Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-3232118 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"SUMOylation of transcription factors" lcl|NW_020311966.1_prot_XP_025602592.1_14482 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" lcl|NW_020311432.1_prot_XP_012268812.1_8427 6 MetaCyc: PWY-4981;MetaCyc: PWY-3341;MetaCyc: PWY-6922;Reactome: R-HSA-8964539;KEGG: 00330+2.6.1.13;MetaCyc: PWY-6344 "L-proline biosynthesis II (from arginine)";"L-proline biosynthesis III (from L-ornithine)";"L-Ndelta-acetylornithine biosynthesis";"Glutamate and glutamine metabolism";"Arginine and proline metabolism";"L-ornithine degradation II (Stickland reaction)" lcl|NW_020311403.1_prot_XP_020708796.1_7732 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311292.1_prot_XP_012262853.1_685 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-112308 "NCAM1 interactions";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening" lcl|NW_020311296.1_prot_XP_020711184.1_999 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311334.1_prot_XP_025601751.1_4347 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311923.1_prot_XP_012264604.1_10507 2 Reactome: R-HSA-3928665;Reactome: R-HSA-2682334 "EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling" lcl|NW_020311980.1_prot_XP_012261311.1_18857 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311370.1_prot_XP_020710067.1_6265 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311992.1_prot_XP_012266341.1_20998 5 KEGG: 00480+6.3.2.3;Reactome: R-HSA-174403;MetaCyc: PWY-8043;Reactome: R-HSA-5579006;KEGG: 00270+6.3.2.3 "Glutathione metabolism";"Glutathione synthesis and recycling";"Ophthalmate biosynthesis";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Cysteine and methionine metabolism" lcl|NW_020311966.1_prot_XP_012256819.1_15179 4 Reactome: R-HSA-71240;Reactome: R-HSA-352230;Reactome: R-HSA-210991;Reactome: R-HSA-5660862 "Tryptophan catabolism";"Amino acid transport across the plasma membrane";"Basigin interactions";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)" lcl|NW_020311294.1_prot_XP_020711017.1_875 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311354.1_prot_XP_012260713.1_5488 2 Reactome: R-HSA-72706;Reactome: R-HSA-72702 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition" lcl|NW_020311934.1_prot_XP_012255034.1_10861 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311977.1_prot_XP_020710579.1_17851 6 MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733 "Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis" lcl|NW_020311988.1_prot_XP_012253478.1_20555 1 Reactome: R-HSA-6790901 "rRNA modification in the nucleus and cytosol" lcl|NW_020311978.1_prot_XP_012258103.1_18398 7 Reactome: R-HSA-2894862;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-2691232 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants" lcl|NW_020311970.1_prot_XP_012259971.1_15588 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311353.1_prot_XP_012255970.1_5458 11 KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05170+2.7.11.1;Reactome: R-HSA-380972;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-9614657;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-163680 "Relaxin signaling pathway";"Thermogenesis";"Regulation of TP53 Activity through Phosphorylation";"Human immunodeficiency virus 1 infection";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"FOXO-mediated transcription of cell death genes";"Human cytomegalovirus infection";"Human papillomavirus infection";"AMPK inhibits chREBP transcriptional activation activity" lcl|NW_020311973.1_prot_XP_012258771.1_16402 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311968.1_prot_XP_012253086.1_15432 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" lcl|NW_020311295.1_prot_XP_012255617.1_921 7 Reactome: R-HSA-2160456;KEGG: 00790+1.14.16.1;KEGG: 00400+1.14.16.1;Reactome: R-HSA-8964208;KEGG: 00360+1.14.16.1;MetaCyc: PWY-7158;MetaCyc: PWY-6134 "Phenylketonuria";"Folate biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Phenylalanine metabolism";"Phenylalanine metabolism";"L-phenylalanine degradation V";"L-tyrosine biosynthesis IV" lcl|NW_020311965.1_prot_XP_012259974.1_14217 5 MetaCyc: PWY-7919;Reactome: R-HSA-532668;Reactome: R-HSA-4793954;KEGG: 00510+3.2.1.106;MetaCyc: PWY-7918 "Protein N-glycosylation processing phase (plants and animals)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-Glycan biosynthesis";"Protein N-glycosylation processing phase (yeast)" lcl|NW_020311995.1_prot_XP_012256976.1_21988 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311350.1_prot_XP_020706616.1_5343 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"RHO GTPases Activate Formins" lcl|NW_020311984.1_prot_XP_012254485.1_19923 11 Reactome: R-HSA-9008059;Reactome: R-HSA-432142;Reactome: R-HSA-391160;Reactome: R-HSA-388841;Reactome: R-HSA-210990;Reactome: R-HSA-909733;Reactome: R-HSA-389948;Reactome: R-HSA-114604;Reactome: R-HSA-912694;Reactome: R-HSA-512988;Reactome: R-HSA-877312 "Interleukin-37 signaling";"Platelet sensitization by LDL";"Signal regulatory protein family interactions";"Costimulation by the CD28 family";"PECAM1 interactions";"Interferon alpha/beta signaling";"PD-1 signaling";"GPVI-mediated activation cascade";"Regulation of IFNA signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of IFNG signaling" lcl|NW_020311995.1_prot_XP_012256758.1_21974 3 Reactome: R-HSA-73843;KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1 "5-Phosphoribose 1-diphosphate biosynthesis";"Pentose phosphate pathway";"Purine metabolism" lcl|NW_020311929.1_prot_XP_012268023.1_10670 2 Reactome: R-HSA-382556;Reactome: R-HSA-5678895 "ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis" lcl|NW_020311286.1_prot_XP_012256194.1_136 5 MetaCyc: PWY-922;KEGG: 00900+2.7.4.2;Reactome: R-HSA-191273;Reactome: R-HSA-2426168;MetaCyc: PWY-7391 "Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Isoprene biosynthesis II (engineered)" lcl|NW_020311978.1_prot_XP_020708669.1_18120 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311982.1_prot_XP_012264643.1_19380 1 Reactome: R-HSA-399956 "CRMPs in Sema3A signaling" lcl|NW_020311401.1_prot_XP_012254997.1_7498 10 KEGG: 00520+5.1.3.2;KEGG: 00052+5.1.3.2;MetaCyc: PWY-7344;MetaCyc: PWY-7328;MetaCyc: PWY-6397;MetaCyc: PWY-3821;Reactome: R-HSA-70370;MetaCyc: PWY-6527;MetaCyc: PWY-6317;Reactome: R-HSA-5609977 "Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"UDP-alpha-D-galactose biosynthesis";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose detoxification";"Galactose catabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)" lcl|NW_020311323.1_prot_XP_012268107.1_3508 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311349.1_prot_XP_012251226.1_5288 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311325.1_prot_XP_012251482.1_3686 3 Reactome: R-HSA-196757;MetaCyc: PWY-2161;KEGG: 00790+6.3.2.17 "Metabolism of folate and pterines";"Folate polyglutamylation";"Folate biosynthesis" lcl|NW_020311975.1_prot_XP_012252352.1_17111 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" lcl|NW_020311973.1_prot_XP_012258637.1_16485 12 MetaCyc: PWY-5873;MetaCyc: PWY-5857;MetaCyc: PWY-5855;MetaCyc: PWY-6708;MetaCyc: PWY-7230;MetaCyc: PWY-5856;Reactome: R-HSA-2142789;MetaCyc: PWY-5870;KEGG: 00130+1.14.99.60;MetaCyc: PWY-5871;MetaCyc: PWY-5872;MetaCyc: PWY-7233 "Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)" lcl|NW_020311925.1_prot_XP_012258418.1_10516 1 Reactome: R-HSA-532668 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" lcl|NW_020311357.1_prot_XP_012266993.1_5599 10 Reactome: R-HSA-2453864;MetaCyc: PWY-5691;Reactome: R-HSA-975634;KEGG: 00230+3.5.2.17;MetaCyc: PWY-7849;Reactome: R-HSA-3000171;MetaCyc: PWY-7394;Reactome: R-HSA-6798695;Reactome: R-HSA-2453902;Reactome: R-HSA-977225 "Retinoid cycle disease events";"Urate conversion to allantoin I";"Retinoid metabolism and transport";"Purine metabolism";"Urate conversion to allantoin III";"Non-integrin membrane-ECM interactions";"Urate conversion to allantoin II";"Neutrophil degranulation";"The canonical retinoid cycle in rods (twilight vision)";"Amyloid fiber formation" lcl|NW_020311939.1_prot_XP_025602338.1_11049 2 Reactome: R-HSA-983168;Reactome: R-HSA-110320 "Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH" lcl|NW_020311407.1_prot_XP_012254810.1_7774 20 MetaCyc: PWY-7338;MetaCyc: PWY-7574;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7007;Reactome: R-HSA-9033241;MetaCyc: PWY-735;MetaCyc: PWY-7606;MetaCyc: PWY-7854;MetaCyc: PWY-7337;MetaCyc: PWY-7291;KEGG: 00592+1.3.3.6;MetaCyc: PWY-6837;MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7288;MetaCyc: PWY-6920;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-7858;KEGG: 00410+1.3.3.6 "10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoyl-coa degradation II";"Propanoate metabolism";"Methyl ketone biosynthesis (engineered)";"Peroxisomal protein import";"Jasmonic acid biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"Fatty acid beta-oxidation VII (yeast peroxisome)";"6-gingerol analog biosynthesis (engineered)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"(5Z)-dodecenoate biosynthesis II";"beta-Alanine metabolism" lcl|NW_020311372.1_prot_XP_020712129.1_6376 9 Reactome: R-HSA-2173791;Reactome: R-HSA-5689603;Reactome: R-HSA-2173788;Reactome: R-HSA-3304356;Reactome: R-HSA-3656535;Reactome: R-HSA-3645790;Reactome: R-HSA-3642279;Reactome: R-HSA-3656532;Reactome: R-HSA-2173789 "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"UCH proteinases";"Downregulation of TGF-beta receptor signaling";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 LBD Mutants in Cancer";"TGFBR2 Kinase Domain Mutants in Cancer";"TGFBR2 MSI Frameshift Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"TGF-beta receptor signaling activates SMADs" lcl|NW_020311973.1_prot_XP_012258609.1_16598 1 Reactome: R-HSA-8964038 "LDL clearance" lcl|NW_020311992.1_prot_XP_012266420.1_21238 6 MetaCyc: PWY-6731;MetaCyc: PWY-6737;KEGG: 00500+2.4.1.1;MetaCyc: PWY-5941;Reactome: R-HSA-70221;MetaCyc: PWY-7238 "Starch degradation III";"Starch degradation V";"Starch and sucrose metabolism";"Glycogen degradation II";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II" lcl|NW_020311892.1_prot_XP_012264708.1_10130 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311503.1_prot_XP_012255260.1_9612 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311977.1_prot_XP_012264036.1_17889 6 Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656 "Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311988.1_prot_XP_012261210.1_20668 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311286.1_prot_XP_012256849.1_59 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311978.1_prot_XP_012257989.1_18085 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311365.1_prot_XP_012269443.1_6020 2 Reactome: R-HSA-5205685;Reactome: R-HSA-983231 "Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production" lcl|NW_020311974.1_prot_XP_012260233.1_16895 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311975.1_prot_XP_012251330.1_16950 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311364.1_prot_XP_020708940.1_5906 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311365.1_prot_XP_020712499.1_6019 2 Reactome: R-HSA-5205685;Reactome: R-HSA-983231 "Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production" lcl|NW_020311298.1_prot_XP_012269884.1_1321 3 Reactome: R-HSA-2024096;Reactome: R-HSA-2206296;Reactome: R-HSA-2024101 "HS-GAG degradation";"MPS II - Hunter syndrome";"CS/DS degradation" lcl|NW_020311296.1_prot_XP_012262836.1_1063 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311994.1_prot_XP_012267464.1_21791 2 KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753 "Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism" lcl|NW_020311432.1_prot_XP_012268936.1_8400 1 Reactome: R-HSA-8850843 "Phosphate bond hydrolysis by NTPDase proteins" lcl|NW_020311343.1_prot_XP_012268662.1_4767 6 MetaCyc: PWY-7900;Reactome: R-HSA-3878781;MetaCyc: PWY-622;KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067;Reactome: R-HSA-3322077 "Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen storage disease type IV (GBE1)";"Starch biosynthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen synthesis" lcl|NW_020311308.1_prot_XP_012264419.1_2187 8 Reactome: R-HSA-9620244;Reactome: R-HSA-438066;Reactome: R-HSA-442982;KEGG: 00230+2.7.4.8;Reactome: R-HSA-9617324;MetaCyc: PWY-7221;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001 "Long-term potentiation";"Unblocking of NMDA receptors, glutamate binding and activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Purine metabolism";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Guanosine ribonucleotides de novo biosynthesis";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade" lcl|NW_020311436.1_prot_XP_012258380.1_8748 1 MetaCyc: PWY-7533 "Gliotoxin biosynthesis" lcl|NW_020311329.1_prot_XP_012269514.1_3985 1 Reactome: R-HSA-73621 "Pyrimidine catabolism" lcl|NW_020311973.1_prot_XP_020708832.1_16394 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311303.1_prot_XP_020710859.1_1717 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311977.1_prot_XP_012263919.1_17859 6 KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656 "Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311958.1_prot_XP_012260388.1_12903 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311966.1_prot_XP_020708249.1_14712 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" lcl|NW_020311975.1_prot_XP_025602711.1_16948 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311289.1_prot_XP_020707371.1_364 9 MetaCyc: PWY-5744;KEGG: 00910+4.2.1.1;Reactome: R-HSA-1475029;MetaCyc: PWY-7115;MetaCyc: PWY-241;MetaCyc: PWY-7117;MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142 "Glyoxylate assimilation";"Nitrogen metabolism";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)" lcl|NW_020311353.1_prot_XP_012255966.1_5463 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311289.1_prot_XP_012253951.1_356 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311393.1_prot_XP_020711300.1_7207 10 KEGG: 00052+2.7.1.11;MetaCyc: PWY-7385;KEGG: 00680+2.7.1.11;Reactome: R-HSA-70171;MetaCyc: PWY-1861;MetaCyc: PWY-5484;KEGG: 00030+2.7.1.11;MetaCyc: PWY-1042;KEGG: 00010+2.7.1.11;KEGG: 00051+2.7.1.11 "Galactose metabolism";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism" lcl|NW_020311978.1_prot_XP_012258110.1_18441 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311331.1_prot_XP_012264308.1_4080 5 Reactome: R-HSA-111457;Reactome: R-HSA-111464;Reactome: R-HSA-9627069;Reactome: R-HSA-111463;Reactome: R-HSA-111469 "Release of apoptotic factors from the mitochondria";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Regulation of the apoptosome activity";"SMAC (DIABLO) binds to IAPs";"SMAC, XIAP-regulated apoptotic response" lcl|NW_020311513.1_prot_XP_020711455.1_9860 29 KEGG: 04151+2.7.11.1;Reactome: R-HSA-5685942;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5685938;Reactome: R-HSA-6803204;Reactome: R-HSA-5693579;Reactome: R-HSA-6804760;Reactome: R-HSA-3371453;Reactome: R-HSA-69473;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693616;Reactome: R-HSA-5693548;KEGG: 05170+2.7.11.1;Reactome: R-HSA-349425;Reactome: R-HSA-5693554;Reactome: R-HSA-2559586;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5693571;Reactome: R-HSA-5693568;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-6804757;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6796648;Reactome: R-HSA-69541;Reactome: R-HSA-6803207 "PI3K-Akt signaling pathway";"HDR through Homologous Recombination (HRR)";"Human papillomavirus infection";"HDR through Single Strand Annealing (SSA)";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Methylation";"Regulation of HSF1-mediated heat shock response";"G2/M DNA damage checkpoint";"Relaxin signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"Sensing of DNA Double Strand Breaks";"Human immunodeficiency virus 1 infection";"Autodegradation of the E3 ubiquitin ligase COP1";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"DNA Damage/Telomere Stress Induced Senescence";"Human cytomegalovirus infection";"Nonhomologous End-Joining (NHEJ)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic recombination";"Processing of DNA double-strand break ends";"Regulation of TP53 Degradation";"Thermogenesis";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"mTOR signaling pathway";"TP53 Regulates Transcription of DNA Repair Genes";"Stabilization of p53";"TP53 Regulates Transcription of Caspase Activators and Caspases" lcl|NW_020311401.1_prot_XP_012254895.1_7528 6 Reactome: R-HSA-1489509;Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13;Reactome: R-HSA-418597;Reactome: R-HSA-2029485;Reactome: R-HSA-1250196 "DAG and IP3 signaling";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"G alpha (z) signalling events";"Role of phospholipids in phagocytosis";"SHC1 events in ERBB2 signaling" lcl|NW_020311981.1_prot_XP_012257600.1_19020 1 Reactome: R-HSA-2024096 "HS-GAG degradation" lcl|NW_020311981.1_prot_XP_012257397.1_19026 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311292.1_prot_XP_012252504.1_584 1 KEGG: 00970+6.1.1.16 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311957.1_prot_XP_012263292.1_12827 2 Reactome: R-HSA-373080;Reactome: R-HSA-3238698 "Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking" lcl|NW_020311973.1_prot_XP_012258822.1_16377 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" lcl|NW_020311465.1_prot_XP_012268980.1_9273 33 MetaCyc: PWY-7396;KEGG: 00350+1.1.1.1;MetaCyc: PWY-5057;MetaCyc: PWY-7111;KEGG: 00830+1.1.1.1;MetaCyc: PWY-7798;KEGG: 00626+1.1.1.1;MetaCyc: PWY-7013;KEGG: 00260+1.1.1.1;KEGG: 00982+1.1.1.1;MetaCyc: PWY-5079;MetaCyc: PWY-7118;MetaCyc: PWY-5751;MetaCyc: PWY-5480;MetaCyc: PWY-6802;MetaCyc: PWY-6313;MetaCyc: PWY-6333;MetaCyc: PWY-5076;KEGG: 00680+1.1.1.284;MetaCyc: PWY-6587;MetaCyc: PWY-5082;MetaCyc: PWY-6342;Reactome: R-HSA-71384;KEGG: 00980+1.1.1.1;MetaCyc: PWY-5486;MetaCyc: PWY-1801;MetaCyc: PWY-3162;KEGG: 00071+1.1.1.1;KEGG: 00592+1.1.1.1;KEGG: 00010+1.1.1.1;MetaCyc: PWY-5078;KEGG: 00625+1.1.1.1;MetaCyc: PWY-6871 "Butanol and isobutanol biosynthesis (engineered)";"Tyrosine metabolism";"L-valine degradation II";"Pyruvate fermentation to isobutanol (engineered)";"Retinol metabolism";"Protein S-nitrosylation and denitrosylation";"Naphthalene degradation";"(S)-propane-1,2-diol degradation";"Glycine, serine and threonine metabolism";"Drug metabolism - cytochrome P450";"L-phenylalanine degradation III";"Chitin degradation to ethanol";"Phenylethanol biosynthesis";"Pyruvate fermentation to ethanol I";"Salidroside biosynthesis";"Serotonin degradation";"Acetaldehyde biosynthesis I";"L-leucine degradation III";"Methane metabolism";"Pyruvate fermentation to ethanol III";"L-methionine degradation III";"Noradrenaline and adrenaline degradation";"Ethanol oxidation";"Metabolism of xenobiotics by cytochrome P450";"Pyruvate fermentation to ethanol II";"Formaldehyde oxidation II (glutathione-dependent)";"L-tryptophan degradation V (side chain pathway)";"Fatty acid degradation";"alpha-Linolenic acid metabolism";"Glycolysis / Gluconeogenesis";"L-isoleucine degradation II";"Chloroalkane and chloroalkene degradation";"3-methylbutanol biosynthesis (engineered)" lcl|NW_020311327.1_prot_XP_012263445.1_3863 13 Reactome: R-HSA-2022857;MetaCyc: PWY-6902;Reactome: R-HSA-2024101;MetaCyc: PWY-7822;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7883;Reactome: R-HSA-2160916;Reactome: R-HSA-1660662;KEGG: 00513+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52 "Keratan sulfate degradation";"Chitin degradation II (Vibrio)";"CS/DS degradation";"Chitin degradation III (Serratia)";"Glycosphingolipid biosynthesis - ganglio series";"Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation";"Glycosphingolipid metabolism";"Various types of N-glycan biosynthesis";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation" lcl|NW_020311943.1_prot_XP_012255222.1_11548 3 Reactome: R-HSA-110328;Reactome: R-HSA-110329;Reactome: R-HSA-110357 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged pyrimidine";"Displacement of DNA glycosylase by APEX1" lcl|NW_020311978.1_prot_XP_012258087.1_18246 3 Reactome: R-HSA-192456;KEGG: 00561+3.1.1.3;MetaCyc: PWY-6857 "Digestion of dietary lipid";"Glycerolipid metabolism";"Retinol biosynthesis" lcl|NW_020311308.1_prot_XP_012253333.1_2224 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311962.1_prot_XP_012252004.1_13708 3 KEGG: 00790+1.1.1.153;Reactome: R-HSA-1474151;Reactome: R-HSA-203615 "Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"eNOS activation" lcl|NW_020311313.1_prot_XP_012261761.1_3064 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311311.1_prot_XP_020706390.1_2470 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311356.1_prot_XP_012267080.1_5577 8 Reactome: R-HSA-77387;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980;KEGG: 00195+7.1.2.2;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-1222556 "Insulin receptor recycling";"Oxidative phosphorylation";"ATP biosynthesis";"Photosynthesis";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Ion channel transport";"ROS and RNS production in phagocytes" lcl|NW_020311956.1_prot_XP_012254589.1_12580 4 Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"RHO GTPases activate KTN1";"Kinesins" lcl|NW_020311977.1_prot_XP_012263905.1_17725 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311393.1_prot_XP_020711319.1_7147 7 MetaCyc: PWY-5698;MetaCyc: PWY-5697;KEGG: 00230+3.5.2.5;MetaCyc: PWY-7790;MetaCyc: PWY-5686;MetaCyc: PWY-7791;KEGG: 00240+3.5.2.3 "Allantoin degradation to ureidoglycolate II (ammonia producing)";"Allantoin degradation to ureidoglycolate I (urea producing)";"Purine metabolism";"UMP biosynthesis II";"UMP biosynthesis I";"UMP biosynthesis III";"Pyrimidine metabolism" lcl|NW_020311955.1_prot_XP_012265478.1_12430 6 Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease" lcl|NW_020311978.1_prot_XP_012257829.1_18042 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311950.1_prot_XP_012264350.1_12102 7 Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311983.1_prot_XP_012267205.1_19474 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311982.1_prot_XP_020708706.1_19223 2 Reactome: R-HSA-975577;Reactome: R-HSA-2022854 "N-Glycan antennae elongation";"Keratan sulfate biosynthesis" lcl|NW_020311995.1_prot_XP_012256891.1_21958 3 Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.51;MetaCyc: PWY-6807 "Neutrophil degranulation";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)" lcl|NW_020311311.1_prot_XP_012250795.1_2471 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311321.1_prot_XP_012263249.1_3434 2 Reactome: R-HSA-2682334;Reactome: R-HSA-3928665 "EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells" lcl|NW_020311513.1_prot_XP_020711388.1_9888 6 Reactome: R-HSA-975578;MetaCyc: PWY-7920;MetaCyc: PWY-7426;Reactome: R-HSA-4793952;KEGG: 00510+2.4.1.143;KEGG: 00513+2.4.1.143 "Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (plants)";"Complex N-linked glycan biosynthesis (vertebrates)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis" lcl|NW_020311976.1_prot_XP_012253605.1_17287 2 MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10 "CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311292.1_prot_XP_025601866.1_732 1 Reactome: R-HSA-5601884 "PIWI-interacting RNA (piRNA) biogenesis" lcl|NW_020311382.1_prot_XP_012268015.1_6858 8 Reactome: R-HSA-2426168;Reactome: R-HSA-191273;MetaCyc: PWY-922;MetaCyc: PWY-7391;MetaCyc: PWY-7524;MetaCyc: PWY-6174;KEGG: 00900+1.1.1.34;Reactome: R-HSA-1989781 "Activation of gene expression by SREBF (SREBP)";"Cholesterol biosynthesis";"Mevalonate pathway I";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway III (archaea)";"Mevalonate pathway II (archaea)";"Terpenoid backbone biosynthesis";"PPARA activates gene expression" lcl|NW_020311441.1_prot_XP_012251257.1_8857 3 MetaCyc: PWY-5386;KEGG: 00620+4.4.1.5;Reactome: R-HSA-70268 "Methylglyoxal degradation I";"Pyruvate metabolism";"Pyruvate metabolism" lcl|NW_020311356.1_prot_XP_012267063.1_5558 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" lcl|NW_020311955.1_prot_XP_012265391.1_12414 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" lcl|NW_020311984.1_prot_XP_012267709.1_20137 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" lcl|NW_020311294.1_prot_XP_020711025.1_872 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311432.1_prot_XP_012268706.1_8461 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311943.1_prot_XP_020707818.1_11702 14 Reactome: R-HSA-2565942;Reactome: R-HSA-5663220;Reactome: R-HSA-380259;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-141444;Reactome: R-HSA-6811436;Reactome: R-HSA-380270;Reactome: R-HSA-2467813;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-380284 "Regulation of PLK1 Activity at G2/M Transition";"RHO GTPases Activate Formins";"Loss of Nlp from mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"COPI-independent Golgi-to-ER retrograde traffic";"Recruitment of mitotic centrosome proteins and complexes";"Separation of Sister Chromatids";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Loss of proteins required for interphase microtubule organization from the centrosome" lcl|NW_020311975.1_prot_XP_012253191.1_16969 4 Reactome: R-HSA-2395516;Reactome: R-HSA-5579026;Reactome: R-HSA-211976;Reactome: R-HSA-196108 "Electron transport from NADPH to Ferredoxin";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Endogenous sterols";"Pregnenolone biosynthesis" lcl|NW_020311309.1_prot_XP_012259097.1_2393 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" lcl|NW_020311975.1_prot_XP_012252634.1_17099 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311985.1_prot_XP_012265229.1_20233 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311461.1_prot_XP_012269158.1_9199 3 Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.5;Reactome: R-HSA-379716 "Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" lcl|NW_020311426.1_prot_XP_020712191.1_8255 3 Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081 "Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling" lcl|NW_020311976.1_prot_XP_012257815.1_17347 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311974.1_prot_XP_020709390.1_16925 2 Reactome: R-HSA-416993;Reactome: R-HSA-202733 "Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall" lcl|NW_020311943.1_prot_XP_012255141.1_11678 2 Reactome: R-HSA-72165;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" lcl|NW_020311977.1_prot_XP_012264060.1_17853 6 MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84 "Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis" lcl|NW_020311975.1_prot_XP_012253818.1_16974 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311332.1_prot_XP_012268505.1_4134 4 Reactome: R-HSA-6798695;Reactome: R-HSA-2162123;Reactome: R-HSA-499943;KEGG: 00590+5.3.99.3 "Neutrophil degranulation";"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)";"Interconversion of nucleotide di- and triphosphates";"Arachidonic acid metabolism" lcl|NW_020311962.1_prot_XP_012251996.1_13702 2 Reactome: R-HSA-6783310;MetaCyc: PWY-7511 "Fanconi Anemia Pathway";"Protein ubiquitination" lcl|NW_020311313.1_prot_XP_012261767.1_2942 5 KEGG: 00670+1.5.1.3;MetaCyc: PWY-3841;KEGG: 00790+1.5.1.3;MetaCyc: PWY-6614;Reactome: R-HSA-196757 "One carbon pool by folate";"Folate transformations II (plants)";"Folate biosynthesis";"Tetrahydrofolate biosynthesis";"Metabolism of folate and pterines" lcl|NW_020311294.1_prot_XP_020711015.1_878 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311961.1_prot_XP_012262747.1_13350 3 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" lcl|NW_020311991.1_prot_XP_012269721.1_20891 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311917.1_prot_XP_012250990.1_10254 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311365.1_prot_XP_012259877.1_5945 16 MetaCyc: PWY-8004;MetaCyc: PWY-6142;MetaCyc: PWY-1042;Reactome: R-HSA-70263;MetaCyc: PWY-6886;MetaCyc: PWY-7124;Reactome: R-HSA-70171;MetaCyc: PWY-1622;KEGG: 00680+4.2.1.11;MetaCyc: PWY-7003;MetaCyc: PWY-6901;MetaCyc: PWY-2221;KEGG: 00010+4.2.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-5723;MetaCyc: PWY-7218 "Entner-Doudoroff pathway I";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)";"Gluconeogenesis";"1-butanol autotrophic biosynthesis (engineered)";"Ethylene biosynthesis V (engineered)";"Glycolysis";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Glycerol degradation to butanol";"Superpathway of glucose and xylose degradation";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Rubisco shunt";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)" lcl|NW_020311977.1_prot_XP_020710648.1_17798 17 MetaCyc: PWY-6679;MetaCyc: PWY-4381;KEGG: 00640+6.4.1.2;Reactome: R-HSA-196780;Reactome: R-HSA-2426168;Reactome: R-HSA-200425;KEGG: 00254+6.4.1.2;Reactome: R-HSA-3371599;Reactome: R-HSA-163765;MetaCyc: PWY-5744;MetaCyc: PWY-5966-1;KEGG: 00720+6.4.1.2;MetaCyc: PWY-6722;KEGG: 00061+6.4.1.2;MetaCyc: PWY-5743;KEGG: 00620+6.4.1.2;MetaCyc: PWY-5789 "Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Propanoate metabolism";"Biotin transport and metabolism";"Activation of gene expression by SREBF (SREBP)";"Carnitine metabolism";"Aflatoxin biosynthesis";"Defective HLCS causes multiple carboxylase deficiency";"ChREBP activates metabolic gene expression";"Glyoxylate assimilation";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Carbon fixation pathways in prokaryotes";"Candicidin biosynthesis";"Fatty acid biosynthesis";"3-hydroxypropanoate cycle";"Pyruvate metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle" lcl|NW_020311325.1_prot_XP_012251463.1_3683 3 Reactome: R-HSA-196757;MetaCyc: PWY-2161;KEGG: 00790+6.3.2.17 "Metabolism of folate and pterines";"Folate polyglutamylation";"Folate biosynthesis" lcl|NW_020311977.1_prot_XP_020707344.1_17546 8 Reactome: R-HSA-68689;Reactome: R-HSA-68827;Reactome: R-HSA-176187;Reactome: R-HSA-113507;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-68616;Reactome: R-HSA-68949 "CDC6 association with the ORC:origin complex";"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"Orc1 removal from chromatin" lcl|NW_020311958.1_prot_XP_025602453.1_12914 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311955.1_prot_XP_012265361.1_12398 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311941.1_prot_XP_020707059.1_11448 2 MetaCyc: PWY-7799;MetaCyc: PWY-7802 "Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)" lcl|NW_020311313.1_prot_XP_012261765.1_2939 7 MetaCyc: PWY-6614;Reactome: R-HSA-69205;KEGG: 00670+1.5.1.3;MetaCyc: PWY-3841;KEGG: 00790+1.5.1.3;Reactome: R-HSA-1474151;Reactome: R-HSA-196757 "Tetrahydrofolate biosynthesis";"G1/S-Specific Transcription";"One carbon pool by folate";"Folate transformations II (plants)";"Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Metabolism of folate and pterines" lcl|NW_020311985.1_prot_XP_020711135.1_20222 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311299.1_prot_XP_012267817.1_1397 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311994.1_prot_XP_012267373.1_21686 5 Reactome: R-HSA-977225;Reactome: R-HSA-5689877;Reactome: R-HSA-9646399;Reactome: R-HSA-983168;Reactome: R-HSA-5205685 "Amyloid fiber formation";"Josephin domain DUBs";"Aggrephagy";"Antigen processing: Ubiquitination & Proteasome degradation";"Pink/Parkin Mediated Mitophagy" lcl|NW_020311989.1_prot_XP_012263188.1_20773 12 MetaCyc: PWY-5857;MetaCyc: PWY-5873;MetaCyc: PWY-5855;MetaCyc: PWY-6708;KEGG: 00130+2.5.1.39;MetaCyc: PWY-6978;MetaCyc: PWY-5870;MetaCyc: PWY-5856;Reactome: R-HSA-2142789;MetaCyc: PWY-5872;Reactome: R-HSA-1268020;MetaCyc: PWY-5871 "Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Plastoquinol-9 biosynthesis II";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-10 biosynthesis (eukaryotic)";"Mitochondrial protein import";"Ubiquinol-9 biosynthesis (eukaryotic)" lcl|NW_020311392.1_prot_XP_012250931.1_7092 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311346.1_prot_XP_020710321.1_5005 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311974.1_prot_XP_012260251.1_16815 1 Reactome: R-HSA-200425 "Carnitine metabolism" lcl|NW_020311346.1_prot_XP_012268605.1_5019 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311296.1_prot_XP_012262835.1_1060 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311959.1_prot_XP_012262413.1_13070 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" lcl|NW_020311424.1_prot_XP_012255408.1_8226 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311978.1_prot_XP_025602791.1_18037 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" lcl|NW_020311317.1_prot_XP_012252443.1_3229 2 KEGG: 00500+2.4.1.15;Reactome: R-HSA-446205 "Starch and sucrose metabolism";"Synthesis of GDP-mannose" lcl|NW_020311977.1_prot_XP_020710728.1_17699 11 Reactome: R-HSA-380270;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-3371497;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-2132295;Reactome: R-HSA-380284;Reactome: R-HSA-6807878;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518 "Recruitment of mitotic centrosome proteins and complexes";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"MHC class II antigen presentation";"Loss of proteins required for interphase microtubule organization from the centrosome";"COPI-mediated anterograde transport";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2" lcl|NW_020311298.1_prot_XP_012250523.1_1359 2 Reactome: R-HSA-416482;Reactome: R-HSA-456926 "G alpha (12/13) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)" lcl|NW_020311973.1_prot_XP_012258581.1_16341 1 Reactome: R-HSA-112126 "ALKBH3 mediated reversal of alkylation damage" lcl|NW_020311298.1_prot_XP_020706286.1_1349 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311994.1_prot_XP_012267587.1_21552 2 Reactome: R-HSA-5663213;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation" lcl|NW_020311984.1_prot_XP_012254557.1_20016 1 Reactome: R-HSA-400253 "Circadian Clock" lcl|NW_020311978.1_prot_XP_012257709.1_18346 13 Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72689 "SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits" lcl|NW_020311401.1_prot_XP_020707757.1_7578 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311983.1_prot_XP_012267255.1_19414 6 Reactome: R-HSA-912446;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-5693616;Reactome: R-HSA-5685942 "Meiotic recombination";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)" lcl|NW_020311980.1_prot_XP_012255708.1_18925 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311417.1_prot_XP_025602033.1_7962 3 Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095 "COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins" lcl|NW_020311304.1_prot_XP_012261105.1_1913 10 Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-2871837;Reactome: R-HSA-5684264;Reactome: R-HSA-5607764;Reactome: R-HSA-2565942 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"CLEC7A (Dectin-1) signaling";"Regulation of PLK1 Activity at G2/M Transition" lcl|NW_020311304.1_prot_XP_012260881.1_1766 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311962.1_prot_XP_012252120.1_13634 1 KEGG: 00860+4.4.1.17 "Porphyrin and chlorophyll metabolism" lcl|NW_020311978.1_prot_XP_012258089.1_18132 3 Reactome: R-HSA-8964058;Reactome: R-HSA-1369062;Reactome: R-HSA-9029569 "HDL remodeling";"ABC transporters in lipid homeostasis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" lcl|NW_020311971.1_prot_XP_012260924.1_15962 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311334.1_prot_XP_020711368.1_4367 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311304.1_prot_XP_012261173.1_1756 5 Reactome: R-HSA-8856825;Reactome: R-HSA-182971;Reactome: R-HSA-8875360;Reactome: R-HSA-8856828;Reactome: R-HSA-6807004 "Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation";"InlB-mediated entry of Listeria monocytogenes into host cell";"Clathrin-mediated endocytosis";"Negative regulation of MET activity" lcl|NW_020311312.1_prot_XP_012266773.1_2676 13 Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-156827 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression" lcl|NW_020311313.1_prot_XP_012261945.1_2860 4 KEGG: 00640+4.1.1.9;KEGG: 00410+4.1.1.9;Reactome: R-HSA-390247;Reactome: R-HSA-9033241 "Propanoate metabolism";"beta-Alanine metabolism";"Beta-oxidation of very long chain fatty acids";"Peroxisomal protein import" lcl|NW_020311329.1_prot_XP_012269598.2_3999 2 KEGG: 00030+2.7.1.15;Reactome: R-HSA-71336 "Pentose phosphate pathway";"Pentose phosphate pathway" lcl|NW_020311433.1_prot_XP_012263639.1_8658 3 Reactome: R-HSA-381426;Reactome: R-HSA-5362798;Reactome: R-HSA-8957275 "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Release of Hh-Np from the secreting cell";"Post-translational protein phosphorylation" lcl|NW_020311287.1_prot_XP_012268115.1_263 4 KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-6483;MetaCyc: PWY-7119 "Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)" lcl|NW_020311340.1_prot_XP_012269667.1_4692 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311393.1_prot_XP_012265770.1_7210 5 Reactome: R-HSA-5625740;Reactome: R-HSA-111447;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-75035 "RHO GTPases activate PKNs";"Activation of BAD and translocation to mitochondria";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" lcl|NW_020311995.1_prot_XP_012257133.1_21937 1 Reactome: R-HSA-429958 "mRNA decay by 3' to 5' exoribonuclease" lcl|NW_020311432.1_prot_XP_020712303.1_8414 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" lcl|NW_020311407.1_prot_XP_020707772.1_7775 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311322.1_prot_XP_012267978.1_3445 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" lcl|NW_020311324.1_prot_XP_020712480.1_3580 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311313.1_prot_XP_020709932.1_2838 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311359.1_prot_XP_012252059.1_5711 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311304.1_prot_XP_012260197.1_1857 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311316.1_prot_XP_012269032.1_3166 2 Reactome: R-HSA-418594;Reactome: R-HSA-375276 "G alpha (i) signalling events";"Peptide ligand-binding receptors" lcl|NW_020311953.1_prot_XP_012260589.1_12264 4 Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163 "Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway" lcl|NW_020311973.1_prot_XP_020708868.1_16361 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311298.1_prot_XP_012269950.1_1186 3 KEGG: 00230+2.7.1.20;MetaCyc: PWY-6619;Reactome: R-HSA-74217 "Purine metabolism";"Adenine and adenosine salvage VI";"Purine salvage" lcl|NW_020311937.1_prot_XP_012252650.1_11024 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311388.1_prot_XP_025601956.1_6992 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311943.1_prot_XP_012255228.1_11544 16 Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339 "Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311978.1_prot_XP_012257987.1_18084 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311426.1_prot_XP_012268511.1_8257 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" lcl|NW_020311940.1_prot_XP_012265695.1_11245 14 MetaCyc: PWY-7619;MetaCyc: PWY-5972;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7601;MetaCyc: PWY-7724;Reactome: R-HSA-75876 "Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Fatty acid elongation";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs" lcl|NW_020311401.1_prot_XP_020707733.1_7648 4 Reactome: R-HSA-4641257;Reactome: R-HSA-418594;Reactome: R-HSA-201681;Reactome: R-HSA-5689880 "Degradation of AXIN";"G alpha (i) signalling events";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases" lcl|NW_020311373.1_prot_XP_012263113.1_6416 5 MetaCyc: PWY-7279;MetaCyc: PWY-3781;MetaCyc: PWY-6692;MetaCyc: PWY-7082;KEGG: 00190+7.1.1.8 "Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration I (cytochrome c)";"Fe(II) oxidation";"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Oxidative phosphorylation" lcl|NW_020311970.1_prot_XP_012267507.1_15787 13 Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-192823 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation" lcl|NW_020311368.1_prot_XP_012264453.1_6206 1 Reactome: R-HSA-8963889 "Assembly of active LPL and LIPC lipase complexes" lcl|NW_020311296.1_prot_XP_012262833.1_1059 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311988.1_prot_XP_020712199.1_20610 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" lcl|NW_020311940.1_prot_XP_012265539.1_11347 3 KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317 "Glycolysis / Gluconeogenesis";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)" lcl|NW_020311959.1_prot_XP_012260470.1_13058 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311380.1_prot_XP_012261405.1_6690 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311396.1_prot_XP_012269588.1_7275 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311992.1_prot_XP_012266536.1_21072 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" lcl|NW_020311970.1_prot_XP_012267575.1_15791 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.4 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311317.1_prot_XP_012254755.1_3194 14 MetaCyc: PWY-7601;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-5972;MetaCyc: PWY-7619 "Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis" lcl|NW_020311957.1_prot_XP_012262083.1_12693 1 Reactome: R-HSA-446203 "Asparagine N-linked glycosylation" lcl|NW_020311977.1_prot_XP_025602765.1_17921 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311393.1_prot_XP_012265744.1_7149 7 KEGG: 00230+3.5.2.5;MetaCyc: PWY-5697;MetaCyc: PWY-5698;MetaCyc: PWY-7791;KEGG: 00240+3.5.2.3;MetaCyc: PWY-5686;MetaCyc: PWY-7790 "Purine metabolism";"Allantoin degradation to ureidoglycolate I (urea producing)";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"UMP biosynthesis III";"Pyrimidine metabolism";"UMP biosynthesis I";"UMP biosynthesis II" lcl|NW_020311992.1_prot_XP_012266328.1_21208 2 Reactome: R-HSA-6798695;Reactome: R-HSA-983168 "Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311475.1_prot_XP_020707125.1_9389 16 Reactome: R-HSA-416476;Reactome: R-HSA-512988;Reactome: R-HSA-114604;Reactome: R-HSA-912631;Reactome: R-HSA-912526;Reactome: R-HSA-8853659;Reactome: R-HSA-194840;Reactome: R-HSA-9009391;Reactome: R-HSA-388841;Reactome: R-HSA-1266695;Reactome: R-HSA-1660499;Reactome: R-HSA-1433557;Reactome: R-HSA-1257604;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558;Reactome: R-HSA-389357 "G alpha (q) signalling events";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"GPVI-mediated activation cascade";"Regulation of signaling by CBL";"Interleukin receptor SHC signaling";"RET signaling";"Rho GTPase cycle";"Extra-nuclear estrogen signaling";"Costimulation by the CD28 family";"Interleukin-7 signaling";"Synthesis of PIPs at the plasma membrane";"Signaling by SCF-KIT";"PIP3 activates AKT signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"CD28 dependent PI3K/Akt signaling" lcl|NW_020311934.1_prot_XP_012255039.1_10865 5 Reactome: R-HSA-6798695;Reactome: R-HSA-1660499;Reactome: R-HSA-8876198;Reactome: R-HSA-8873719;Reactome: R-HSA-1445148 "Neutrophil degranulation";"Synthesis of PIPs at the plasma membrane";"RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311432.1_prot_XP_012268935.1_8399 1 Reactome: R-HSA-8850843 "Phosphate bond hydrolysis by NTPDase proteins" lcl|NW_020311308.1_prot_XP_020707135.1_2225 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311995.1_prot_XP_012257126.2_22002 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311994.1_prot_XP_012267381.1_21762 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311955.1_prot_XP_012265322.1_12482 6 KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23 "Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Glycosaminoglycan degradation";"Galactose metabolism" lcl|NW_020311329.1_prot_XP_012258932.1_3935 13 Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706 "Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311306.1_prot_XP_012264178.1_2111 1 Reactome: R-HSA-5632928 "Defective Mismatch Repair Associated With MSH2" lcl|NW_020311983.1_prot_XP_012268303.1_19602 1 Reactome: R-HSA-379716 "Cytosolic tRNA aminoacylation" lcl|NW_020311933.1_prot_XP_012252841.1_10766 18 MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;KEGG: 00564+3.1.1.4;KEGG: 00590+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-7417;Reactome: R-HSA-1483166;Reactome: R-HSA-1482922;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-8053;Reactome: R-HSA-1482788;Reactome: R-HSA-1482801;MetaCyc: PWY-8051;Reactome: R-HSA-1482839;Reactome: R-HSA-1482925;MetaCyc: PWY-7783 "Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Glycerophospholipid metabolism";"Arachidonic acid metabolism";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidate, yeast)";"Synthesis of PA";"Acyl chain remodelling of PI";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PC";"Acyl chain remodelling of PS";"Anandamide biosynthesis I";"Acyl chain remodelling of PE";"Acyl chain remodelling of PG";"Plasmalogen degradation" lcl|NW_020311373.1_prot_XP_012262984.1_6403 1 Reactome: R-HSA-417973 "Adenosine P1 receptors" lcl|NW_020311970.1_prot_XP_012269108.1_15649 19 Reactome: R-HSA-8856825;Reactome: R-HSA-8866423;Reactome: R-HSA-8957275;Reactome: R-HSA-3000480;Reactome: R-HSA-8964046;Reactome: R-HSA-8964041;Reactome: R-HSA-202733;Reactome: R-HSA-8964038;Reactome: R-HSA-8964026;Reactome: R-HSA-8856828;Reactome: R-HSA-8963888;Reactome: R-HSA-3000497;Reactome: R-HSA-3000484;Reactome: R-HSA-975634;Reactome: R-HSA-8963901;Reactome: R-HSA-3000471;Reactome: R-HSA-432142;Reactome: R-HSA-381426;Reactome: R-HSA-5686938 "Cargo recognition for clathrin-mediated endocytosis";"VLDL assembly";"Post-translational protein phosphorylation";"Scavenging by Class A Receptors";"VLDL clearance";"LDL remodeling";"Cell surface interactions at the vascular wall";"LDL clearance";"Chylomicron clearance";"Clathrin-mediated endocytosis";"Chylomicron assembly";"Scavenging by Class H Receptors";"Scavenging by Class F Receptors";"Retinoid metabolism and transport";"Chylomicron remodeling";"Scavenging by Class B Receptors";"Platelet sensitization by LDL";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Regulation of TLR by endogenous ligand" lcl|NW_020311985.1_prot_XP_020707335.1_20297 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" lcl|NW_020311298.1_prot_XP_012269868.1_1315 6 Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-72689 "Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits" lcl|NW_020311966.1_prot_XP_012256822.1_15183 22 Reactome: R-HSA-5467340;Reactome: R-HSA-5339716;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5358749;Reactome: R-HSA-5358752;Reactome: R-HSA-6811558;Reactome: R-HSA-5673000;Reactome: R-HSA-432142;Reactome: R-HSA-5467337;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-195253;Reactome: R-HSA-5467348;Reactome: R-HSA-5358747;Reactome: R-HSA-4641262;Reactome: R-HSA-5675221;Reactome: R-HSA-389513;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-196299;Reactome: R-HSA-5358751 "AXIN missense mutants destabilize the destruction complex";"Misspliced GSK3beta mutants stabilize beta-catenin";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"S37 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RAF activation";"Platelet sensitization by LDL";"APC truncation mutants have impaired AXIN binding";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Degradation of beta-catenin by the destruction complex";"Truncations of AMER1 destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Negative regulation of MAPK pathway";"CTLA4 inhibitory signaling";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Beta-catenin phosphorylation cascade";"S45 mutants of beta-catenin aren't phosphorylated" lcl|NW_020311992.1_prot_XP_012266369.1_21152 1 Reactome: R-HSA-912446 "Meiotic recombination" lcl|NW_020311382.1_prot_XP_012268030.1_6870 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311994.1_prot_XP_020710046.1_21846 4 Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-2022090;Reactome: R-HSA-1650814 "Collagen chain trimerization";"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures";"Collagen biosynthesis and modifying enzymes" lcl|NW_020311968.1_prot_XP_012253082.1_15425 11 Reactome: R-HSA-6804114;Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-2426168;Reactome: R-HSA-9018519;Reactome: R-HSA-1368082;Reactome: R-HSA-3214858;Reactome: R-HSA-400206;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-381340 "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"Activation of gene expression by SREBF (SREBP)";"Estrogen-dependent gene expression";"RORA activates gene expression";"RMTs methylate histone arginines";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311359.1_prot_XP_012252101.1_5707 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" lcl|NW_020311988.1_prot_XP_020709731.1_20702 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157 "MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions" lcl|NW_020311983.1_prot_XP_012267230.1_19430 8 Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-983231;Reactome: R-HSA-432040;Reactome: R-HSA-381676;Reactome: R-HSA-442720;Reactome: R-HSA-180024 "PKA activation";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"Factors involved in megakaryocyte development and platelet production";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"DARPP-32 events" lcl|NW_020311367.1_prot_XP_020709009.1_6074 3 Reactome: R-HSA-429947;Reactome: R-HSA-380994;Reactome: R-HSA-450604 "Deadenylation of mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA" lcl|NW_020311477.1_prot_XP_020710088.1_9429 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311977.1_prot_XP_012264079.1_17773 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311984.1_prot_XP_012264709.1_19821 8 MetaCyc: PWY-6901;Reactome: R-HSA-70268;KEGG: 00270+1.1.1.27;MetaCyc: PWY-8086;KEGG: 00620+1.1.1.27;KEGG: 00010+1.1.1.27;MetaCyc: PWY-5481;KEGG: 00640+1.1.1.27 "Superpathway of glucose and xylose degradation";"Pyruvate metabolism";"Cysteine and methionine metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Pyruvate fermentation to (S)-lactate";"Propanoate metabolism" lcl|NW_020311392.1_prot_XP_020706412.1_7084 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311373.1_prot_XP_012266677.1_6431 13 Reactome: R-HSA-3928662;Reactome: R-HSA-4420097;Reactome: R-HSA-416572;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5627117;Reactome: R-HSA-3928663;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-416482 "EPHB-mediated forward signaling";"VEGFA-VEGFR2 Pathway";"Sema4D induced cell migration and growth-cone collapse";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"RHO GTPases Activate ROCKs";"EPHA-mediated growth cone collapse";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"G alpha (12/13) signalling events" lcl|NW_020311994.1_prot_XP_012267335.1_21646 7 MetaCyc: PWY-6596;KEGG: 00983+1.1.1.205;Reactome: R-HSA-6798695;Reactome: R-HSA-73817;MetaCyc: PWY-7221;MetaCyc: PWY-5695;KEGG: 00230+1.1.1.205 "Adenosine nucleotides degradation I";"Drug metabolism - other enzymes";"Neutrophil degranulation";"Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Inosine 5'-phosphate degradation";"Purine metabolism" lcl|NW_020311369.1_prot_XP_012264140.1_6237 5 MetaCyc: PWY-7863;MetaCyc: PWY-5523;Reactome: R-HSA-196843;KEGG: 00740+2.7.1.26;MetaCyc: PWY-6168 "Roseoflavin biosynthesis";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Vitamin B2 (riboflavin) metabolism";"Riboflavin metabolism";"Flavin biosynthesis III (fungi)" lcl|NW_020311310.1_prot_XP_012255724.1_2440 5 Reactome: R-HSA-189085;KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902 "Digestion of dietary carbohydrate";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)" lcl|NW_020311984.1_prot_XP_012267650.1_20075 6 MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782 "Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311985.1_prot_XP_020707349.1_20292 9 MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5744;MetaCyc: PWY-241;MetaCyc: PWY-7117;MetaCyc: PWY-7115 "3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type" lcl|NW_020311983.1_prot_XP_020711784.1_19445 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" lcl|NW_020311967.1_prot_XP_012256016.1_15263 9 KEGG: 05165+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-198323;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"AKT phosphorylates targets in the cytosol";"Thermogenesis";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311317.1_prot_XP_012254747.1_3193 14 KEGG: 00062+2.3.1.199;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7601;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7725 "Fatty acid elongation";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)" lcl|NW_020311917.1_prot_XP_012250976.1_10258 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311940.1_prot_XP_012265570.1_11201 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311286.1_prot_XP_012256884.1_146 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311420.1_prot_XP_020709539.1_8123 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311966.1_prot_XP_012256955.1_14726 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311976.1_prot_XP_012257895.1_17362 3 Reactome: R-HSA-9033241;Reactome: R-HSA-8866654;Reactome: R-HSA-9603798 "Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Class I peroxisomal membrane protein import" lcl|NW_020311978.1_prot_XP_025602793.1_18034 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" lcl|NW_020311984.1_prot_XP_020711940.1_20081 2 Reactome: R-HSA-8939243;Reactome: R-HSA-8953750 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Transcriptional Regulation by E2F6" lcl|NW_020311974.1_prot_XP_012260118.1_16870 1 Reactome: R-HSA-446210 "Synthesis of UDP-N-acetyl-glucosamine" lcl|NW_020311448.1_prot_XP_012252688.1_9007 1 Reactome: R-HSA-977347 "Serine biosynthesis" lcl|NW_020311436.1_prot_XP_012258435.1_8785 1 Reactome: R-HSA-5689877 "Josephin domain DUBs" lcl|NW_020311974.1_prot_XP_020709330.1_16710 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311995.1_prot_XP_012257306.1_22031 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" lcl|NW_020311966.1_prot_XP_020708091.1_14944 2 Reactome: R-HSA-5205685;Reactome: R-HSA-1268020 "Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import" lcl|NW_020311976.1_prot_XP_020707193.1_17306 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" lcl|NW_020311306.1_prot_XP_012265947.1_2139 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311971.1_prot_XP_020710499.1_16126 2 Reactome: R-HSA-190873;Reactome: R-HSA-399719 "Gap junction degradation";"Trafficking of AMPA receptors" lcl|NW_020311994.1_prot_XP_012267499.1_21659 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311961.1_prot_XP_012262653.1_13462 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311978.1_prot_XP_020708584.1_18058 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311988.1_prot_XP_012266694.1_20625 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311943.1_prot_XP_012255147.1_11635 3 KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00250+3.5.1.1 "Cyanoamino acid metabolism";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311312.1_prot_XP_012266946.1_2594 3 Reactome: R-HSA-8866654;Reactome: R-HSA-9033241;Reactome: R-HSA-9603798 "E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import";"Class I peroxisomal membrane protein import" lcl|NW_020311943.1_prot_XP_012254704.1_11618 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311302.1_prot_XP_025602692.1_1711 4 Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex" lcl|NW_020311985.1_prot_XP_020711136.1_20223 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311373.1_prot_XP_012263114.1_6415 5 MetaCyc: PWY-3781;MetaCyc: PWY-7279;KEGG: 00190+7.1.1.8;MetaCyc: PWY-7082;MetaCyc: PWY-6692 "Aerobic respiration I (cytochrome c)";"Aerobic respiration II (cytochrome c) (yeast)";"Oxidative phosphorylation";"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Fe(II) oxidation" lcl|NW_020311966.1_prot_XP_012257383.1_14450 2 Reactome: R-HSA-5694530;Reactome: R-HSA-204005 "Cargo concentration in the ER";"COPII-mediated vesicle transport" lcl|NW_020311983.1_prot_XP_012255514.1_19782 8 Reactome: R-HSA-6787639;KEGG: 00051+4.2.1.47;MetaCyc: PWY-5738;MetaCyc: PWY-66;KEGG: 00520+4.2.1.47;MetaCyc: PWY-7573;MetaCyc: PWY-5739;MetaCyc: PWY-5740 "GDP-fucose biosynthesis";"Fructose and mannose metabolism";"GDP-6-deoxy-D-talose biosynthesis";"GDP-L-fucose biosynthesis I (from GDP-D-mannose)";"Amino sugar and nucleotide sugar metabolism";"GDP-mycosamine biosynthesis";"GDP-D-perosamine biosynthesis";"GDP-L-colitose biosynthesis" lcl|NW_020311991.1_prot_XP_012269724.1_20940 16 Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902 "Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation" lcl|NW_020311287.1_prot_XP_012268121.1_282 6 Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311946.1_prot_XP_012268642.1_11919 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311298.1_prot_XP_012269878.1_1339 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" lcl|NW_020311292.1_prot_XP_025601936.1_520 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311983.1_prot_XP_025602881.1_19713 2 KEGG: 00970+6.1.1.10;KEGG: 00450+6.1.1.10 "Aminoacyl-tRNA biosynthesis";"Selenocompound metabolism" lcl|NW_020311315.1_prot_XP_012265249.1_3100 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" lcl|NW_020311973.1_prot_XP_012258820.1_16629 2 MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311971.1_prot_XP_012263525.1_16108 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311917.1_prot_XP_012251535.1_10200 17 Reactome: R-HSA-167238;Reactome: R-HSA-167242;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-167287;KEGG: 04658+3.1.3.16;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-167158;KEGG: 05235+3.1.3.16;Reactome: R-HSA-167152;KEGG: 04660+3.1.3.16;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-113418 "Pausing and recovery of Tat-mediated HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Th1 and Th2 cell differentiation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Formation of HIV elongation complex in the absence of HIV Tat";"T cell receptor signaling pathway";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Formation of the Early Elongation Complex" lcl|NW_020311332.1_prot_XP_025601738.1_4131 1 KEGG: 00970+6.1.1.1 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311980.1_prot_XP_012253973.1_18736 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311978.1_prot_XP_012258071.1_18249 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311285.1_prot_XP_012256108.1_32 5 Reactome: R-HSA-5610785;Reactome: R-HSA-5632684;Reactome: R-HSA-5610787;Reactome: R-HSA-5610783;Reactome: R-HSA-5610780 "GLI3 is processed to GLI3R by the proteasome";"Hedgehog 'on' state";"Hedgehog 'off' state";"Degradation of GLI2 by the proteasome";"Degradation of GLI1 by the proteasome" lcl|NW_020311299.1_prot_XP_012263277.1_1435 1 Reactome: R-HSA-4419969 "Depolymerisation of the Nuclear Lamina" lcl|NW_020311975.1_prot_XP_012252954.1_16960 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311304.1_prot_XP_012260527.1_1774 5 Reactome: R-HSA-5218921;Reactome: R-HSA-186763;Reactome: R-HSA-8849471;Reactome: R-HSA-3928662;Reactome: R-HSA-5658442 "VEGFR2 mediated cell proliferation";"Downstream signal transduction";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases";"EPHB-mediated forward signaling";"Regulation of RAS by GAPs" lcl|NW_020311991.1_prot_XP_012269807.1_20861 1 Reactome: R-HSA-442660 "Na+/Cl- dependent neurotransmitter transporters" lcl|NW_020311380.1_prot_XP_020712080.1_6697 3 Reactome: R-HSA-416476;Reactome: R-HSA-375276;Reactome: R-HSA-418594 "G alpha (q) signalling events";"Peptide ligand-binding receptors";"G alpha (i) signalling events" lcl|NW_020311482.1_prot_XP_020708503.1_9476 1 Reactome: R-HSA-114608 "Platelet degranulation" lcl|NW_020311329.1_prot_XP_012258973.1_3941 4 Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-1912420;Reactome: R-HSA-936837 "Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Pre-NOTCH Processing in Golgi";"Ion transport by P-type ATPases" lcl|NW_020311317.1_prot_XP_012250732.1_3259 10 Reactome: R-HSA-201688;Reactome: R-HSA-445144;Reactome: R-HSA-2514853;Reactome: R-HSA-8948751;Reactome: R-HSA-8934903;Reactome: R-HSA-1483191;Reactome: R-HSA-6798695;Reactome: R-HSA-8939243;Reactome: R-HSA-6804756;Reactome: R-HSA-6814122 "WNT mediated activation of DVL";"Signal transduction by L1";"Condensation of Prometaphase Chromosomes";"Regulation of PTEN stability and activity";"Receptor Mediated Mitophagy";"Synthesis of PC";"Neutrophil degranulation";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Regulation of TP53 Activity through Phosphorylation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" lcl|NW_020311966.1_prot_XP_012256390.1_14947 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311961.1_prot_XP_012262672.1_13432 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311403.1_prot_XP_025601997.1_7734 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311294.1_prot_XP_020711009.1_884 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311313.1_prot_XP_012261888.1_2877 16 Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-6791226 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Translation initiation complex formation";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311391.1_prot_XP_012257042.1_7019 2 KEGG: 00511+3.2.1.96;Reactome: R-HSA-532668 "Other glycan degradation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle" lcl|NW_020311944.1_prot_XP_012254208.1_11776 2 Reactome: R-HSA-877312;Reactome: R-HSA-6807004 "Regulation of IFNG signaling";"Negative regulation of MET activity" lcl|NW_020311967.1_prot_XP_012256025.1_15255 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311958.1_prot_XP_020707835.1_12925 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311334.1_prot_XP_012265836.1_4353 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311984.1_prot_XP_012267651.1_20076 6 MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782 "Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311312.1_prot_XP_012266939.1_2589 14 Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-1632852;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-5620924;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025 "Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Macroautophagy";"HCMV Early Events";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Intraflagellar transport";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311995.1_prot_XP_012256780.1_21910 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311957.1_prot_XP_012263392.1_12864 8 Reactome: R-HSA-917977;Reactome: R-HSA-9636467;Reactome: R-HSA-182218;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-167590 "Transferrin endocytosis and recycling";"Blockage of phagosome acidification";"Nef Mediated CD8 Down-regulation";"Amino acids regulate mTORC1";"Ion channel transport";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Nef Mediated CD4 Down-regulation" lcl|NW_020311292.1_prot_XP_012252414.1_567 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311982.1_prot_XP_012264610.1_19385 1 Reactome: R-HSA-611105 "Respiratory electron transport" lcl|NW_020311964.1_prot_XP_012261666.1_14004 2 Reactome: R-HSA-425397;Reactome: R-HSA-5619061 "Transport of vitamins, nucleosides, and related molecules";"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)" lcl|NW_020311311.1_prot_XP_020706401.1_2510 3 Reactome: R-HSA-114608;Reactome: R-HSA-195399;Reactome: R-HSA-194313 "Platelet degranulation";"VEGF binds to VEGFR leading to receptor dimerization";"VEGF ligand-receptor interactions" lcl|NW_020311971.1_prot_XP_025602663.1_15860 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311983.1_prot_XP_012268356.1_19636 13 Reactome: R-HSA-6798695;Reactome: R-HSA-2022857;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2024096;KEGG: 00531+3.2.1.23;Reactome: R-HSA-2206308;Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;Reactome: R-HSA-4341670;KEGG: 00604+3.2.1.23 "Neutrophil degranulation";"Keratan sulfate degradation";"Galactose metabolism";"Other glycan degradation";"HS-GAG degradation";"Glycosaminoglycan degradation";"MPS IV - Morquio syndrome B";"Glycosphingolipid metabolism";"Sialic acid metabolism";"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Defective NEU1 causes sialidosis";"Glycosphingolipid biosynthesis - ganglio series" lcl|NW_020311983.1_prot_XP_025602879.1_19525 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311977.1_prot_XP_012263779.1_17706 6 Reactome: R-HSA-3371599;KEGG: 00785+2.3.1.181;KEGG: 00780+6.3.4.15;Reactome: R-HSA-196780;MetaCyc: PWY-7382;MetaCyc: PWY-6987 "Defective HLCS causes multiple carboxylase deficiency";"Lipoic acid metabolism";"Biotin metabolism";"Biotin transport and metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoate biosynthesis and incorporation III (Bacillus)" lcl|NW_020311966.1_prot_XP_020708232.1_14751 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311340.1_prot_XP_012269650.1_4681 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311976.1_prot_XP_020707170.1_17216 3 Reactome: R-HSA-4420097;Reactome: R-HSA-391160;KEGG: 04660+2.7.10.2 "VEGFA-VEGFR2 Pathway";"Signal regulatory protein family interactions";"T cell receptor signaling pathway" lcl|NW_020311984.1_prot_XP_012254569.1_19992 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311971.1_prot_XP_020710529.1_16078 12 Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-68877 "COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"HCMV Early Events";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Mitotic Prometaphase" lcl|NW_020311992.1_prot_XP_012266366.1_21151 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311934.1_prot_XP_012255369.1_10852 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311943.1_prot_XP_012254980.1_11667 3 KEGG: 00260+3.1.3.3;KEGG: 00680+3.1.3.3;Reactome: R-HSA-977347 "Glycine, serine and threonine metabolism";"Methane metabolism";"Serine biosynthesis" lcl|NW_020311966.1_prot_XP_012256420.1_15156 11 Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-380270 "AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311294.1_prot_XP_020711024.1_876 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" lcl|NW_020311971.1_prot_XP_012260812.1_15859 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311962.1_prot_XP_012252076.1_13696 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311995.1_prot_XP_012256660.1_22052 2 MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21 "Mitochondrial L-carnitine shuttle";"Fatty acid degradation" lcl|NW_020311967.1_prot_XP_012254326.1_15277 7 Reactome: R-HSA-1538133;Reactome: R-HSA-1362300;Reactome: R-HSA-69202;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-156711 "G0 and Early G1";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Polo-like kinase mediated events" lcl|NW_020311418.1_prot_XP_012261011.1_8009 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311367.1_prot_XP_012258979.1_6097 10 KEGG: 00460+2.3.2.2;MetaCyc: PWY-7559;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-5826;MetaCyc: PWY-4041;MetaCyc: PWY-6842;MetaCyc: PWY-8001;MetaCyc: PWY-7112 "Cyanoamino acid metabolism";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification I";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"Hypoglycin biosynthesis";"Gamma-glutamyl cycle";"Glutathione-mediated detoxification II";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"4-hydroxy-2-nonenal detoxification" lcl|NW_020311983.1_prot_XP_012268319.1_19551 6 MetaCyc: PWY-7511;Reactome: R-HSA-8948751;Reactome: R-HSA-8863795;Reactome: R-HSA-8939902;Reactome: R-HSA-2173788;Reactome: R-HSA-983168 "Protein ubiquitination";"Regulation of PTEN stability and activity";"Downregulation of ERBB2 signaling";"Regulation of RUNX2 expression and activity";"Downregulation of TGF-beta receptor signaling";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311286.1_prot_XP_012256851.1_60 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311971.1_prot_XP_020710528.1_16076 12 Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436 "Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311513.1_prot_XP_020711387.1_9887 6 MetaCyc: PWY-7920;Reactome: R-HSA-975578;MetaCyc: PWY-7426;Reactome: R-HSA-4793952;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143 "Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis" lcl|NW_020311370.1_prot_XP_020710069.1_6267 3 KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16 "Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer" lcl|NW_020311965.1_prot_XP_020709340.1_14183 1 Reactome: R-HSA-1614517 "Sulfide oxidation to sulfate" lcl|NW_020311296.1_prot_XP_012264908.1_1002 2 Reactome: R-HSA-381038;Reactome: R-HSA-1799339 "XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311984.1_prot_XP_012254506.1_19947 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311286.1_prot_XP_012257193.1_100 2 Reactome: R-HSA-72163;Reactome: R-HSA-6807505 "mRNA Splicing - Major Pathway";"RNA polymerase II transcribes snRNA genes" lcl|NW_020311969.1_prot_XP_020710941.1_15569 7 Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-8854518 "Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2" lcl|NW_020311381.1_prot_XP_012252332.1_6834 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5689880 "UCH proteinases";"Ub-specific processing proteases" lcl|NW_020311332.1_prot_XP_020708076.1_4199 5 Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes" lcl|NW_020311962.1_prot_XP_012251970.1_13775 4 Reactome: R-HSA-4551295;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.131;KEGG: 00513+2.4.1.131 "Defective ALG11 causes ALG11-CDG (CDG-1p)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis" lcl|NW_020311959.1_prot_XP_012262290.1_13090 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311353.1_prot_XP_020708029.1_5397 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311975.1_prot_XP_012251342.1_16946 1 Reactome: R-HSA-163560 "Triglyceride catabolism" lcl|NW_020311993.1_prot_XP_012261872.1_21406 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" lcl|NW_020311408.1_prot_XP_020710020.1_7799 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311300.1_prot_XP_012253147.1_1502 7 Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912 "Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane" lcl|NW_020311397.1_prot_XP_020708719.1_7303 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" lcl|NW_020311985.1_prot_XP_012265298.1_20191 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311349.1_prot_XP_012251139.1_5282 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311936.1_prot_XP_012261260.1_10983 2 Reactome: R-HSA-110320;Reactome: R-HSA-983168 "Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311418.1_prot_XP_020709684.1_7990 2 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.1 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311974.1_prot_XP_020709328.1_16708 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311917.1_prot_XP_012250933.1_10214 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311298.1_prot_XP_012269887.1_1337 3 Reactome: R-HSA-480985;KEGG: 00510+2.4.1.117;Reactome: R-HSA-913709 "Synthesis of dolichyl-phosphate-glucose";"N-Glycan biosynthesis";"O-linked glycosylation of mucins" lcl|NW_020311993.1_prot_XP_012261946.1_21397 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311361.1_prot_XP_012261590.1_5836 7 MetaCyc: PWY-7039;Reactome: R-HSA-2029485;MetaCyc: PWY-3561;Reactome: R-HSA-1483166;KEGG: 00565+3.1.4.4;Reactome: R-HSA-1483148;KEGG: 00564+3.1.4.4 "Phosphatidate metabolism, as a signaling molecule";"Role of phospholipids in phagocytosis";"Choline biosynthesis III";"Synthesis of PA";"Ether lipid metabolism";"Synthesis of PG";"Glycerophospholipid metabolism" lcl|NW_020311331.1_prot_XP_012264300.1_4076 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311957.1_prot_XP_012262119.1_12730 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311982.1_prot_XP_012258135.1_19224 2 Reactome: R-HSA-2022854;Reactome: R-HSA-975577 "Keratan sulfate biosynthesis";"N-Glycan antennae elongation" lcl|NW_020311334.1_prot_XP_012265918.1_4374 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311973.1_prot_XP_020708931.1_16628 2 KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261 "Glycerolipid metabolism";"Glycerol degradation I" lcl|NW_020311327.1_prot_XP_012252913.1_3751 2 Reactome: R-HSA-8963888;Reactome: R-HSA-8866423 "Chylomicron assembly";"VLDL assembly" lcl|NW_020311958.1_prot_XP_012260387.1_12904 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311988.1_prot_XP_020706217.1_20621 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311994.1_prot_XP_012267616.1_21765 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" lcl|NW_020311425.1_prot_XP_012265061.1_8240 3 Reactome: R-HSA-6798695;Reactome: R-HSA-202427;Reactome: R-HSA-6807004 "Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity" lcl|NW_020311994.1_prot_XP_012267550.1_21800 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311961.1_prot_XP_020710175.1_13328 2 Reactome: R-HSA-72163;Reactome: R-HSA-430039 "mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311436.1_prot_XP_020708770.1_8773 3 Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596 "Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I" lcl|NW_020311965.1_prot_XP_012259842.1_14051 32 Reactome: R-HSA-6807505;Reactome: R-HSA-167242;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167158;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-168325;Reactome: R-HSA-9018519;Reactome: R-HSA-76042;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-167238;Reactome: R-HSA-73776;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-77075;Reactome: R-HSA-72165;Reactome: R-HSA-8851708;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-167161;Reactome: R-HSA-75955;Reactome: R-HSA-6803529;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-167290;Reactome: R-HSA-72086 "RNA polymerase II transcribes snRNA genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Formation of the HIV-1 Early Elongation Complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Viral Messenger RNA Synthesis";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Promoter Escape";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Splicing - Minor Pathway";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"HIV Transcription Initiation";"RNA Polymerase II Transcription Elongation";"FGFR2 alternative splicing";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Pausing and recovery of HIV elongation";"mRNA Capping" lcl|NW_020311291.1_prot_XP_012259618.1_457 3 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" lcl|NW_020311995.1_prot_XP_020708160.1_22036 9 Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-76042;Reactome: R-HSA-73779 "Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311497.1_prot_XP_012252145.1_9506 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" lcl|NW_020311965.1_prot_XP_025602551.1_14265 5 Reactome: R-HSA-6782861;Reactome: R-HSA-196843;MetaCyc: PWY-7285;MetaCyc: PWY-6829;MetaCyc: PWY-7286 "Synthesis of wybutosine at G37 of tRNA(Phe)";"Vitamin B2 (riboflavin) metabolism";"Methylwyosine biosynthesis";"Trna methylation (yeast)";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis" lcl|NW_020311979.1_prot_XP_012259474.1_18557 8 KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Human papillomavirus infection";"Activation of RAC1";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311958.1_prot_XP_025602448.1_12917 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311981.1_prot_XP_012257353.1_19066 52 Reactome: R-HSA-112382;Reactome: R-HSA-167158;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-76066;Reactome: R-HSA-76042;Reactome: R-HSA-73762;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-76061;Reactome: R-HSA-6807505;Reactome: R-HSA-167242;Reactome: R-HSA-6796648;Reactome: R-HSA-73863;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-167172;Reactome: R-HSA-72165;Reactome: R-HSA-77075;Reactome: R-HSA-75953;Reactome: R-HSA-8851708;Reactome: R-HSA-674695;Reactome: R-HSA-72203;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-203927;Reactome: R-HSA-167161;Reactome: R-HSA-75955;Reactome: R-HSA-6803529;Reactome: R-HSA-6781827;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-5601884;Reactome: R-HSA-73980;Reactome: R-HSA-72086;Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-5578749;Reactome: R-HSA-167162;Reactome: R-HSA-167238;Reactome: R-HSA-73776;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-5617472;Reactome: R-HSA-1834949;Reactome: R-HSA-5250924;Reactome: R-HSA-73780 "Formation of RNA Pol II elongation complex";"Formation of the HIV-1 Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA polymerase II transcribes snRNA genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"Transcription of the HIV genome";"mRNA Splicing - Minor Pathway";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Pre-transcription Events";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"MicroRNA (miRNA) biogenesis";"HIV Transcription Initiation";"RNA Polymerase II Transcription Elongation";"FGFR2 alternative splicing";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase III Transcription Termination";"mRNA Capping";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"Transcriptional regulation by small RNAs";"RNA Polymerase II HIV Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Promoter Escape";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Cytosolic sensors of pathogen-associated DNA";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Chain Elongation" lcl|NW_020311992.1_prot_XP_020711592.2_21244 14 MetaCyc: PWY-6433;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-5972;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7602 "Hydroxylated fatty acid biosynthesis (plants)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)" lcl|NW_020311978.1_prot_XP_012257885.1_18438 6 MetaCyc: PWY-2221;KEGG: 00930+3.1.1.17;MetaCyc: PWY-7165;KEGG: 00053+3.1.1.17;KEGG: 00030+3.1.1.17;MetaCyc: PWY-5530 "Entner-Doudoroff pathway III (semi-phosphorylative)";"Caprolactam degradation";"L-ascorbate biosynthesis VI (engineered pathway)";"Ascorbate and aldarate metabolism";"Pentose phosphate pathway";"Sorbitol biosynthesis II" lcl|NW_020311966.1_prot_XP_012256958.1_14723 3 MetaCyc: PWY-7286;MetaCyc: PWY-7285;MetaCyc: PWY-6829 "7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Methylwyosine biosynthesis";"Trna methylation (yeast)" lcl|NW_020311955.1_prot_XP_012265320.1_12481 6 KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23 "Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Galactose metabolism" lcl|NW_020311460.1_prot_XP_020707531.1_9190 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" lcl|NW_020311947.1_prot_XP_012260479.1_11966 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" lcl|NW_020311965.1_prot_XP_012260274.1_14158 4 KEGG: 00510+2.4.1.258;Reactome: R-HSA-446193;Reactome: R-HSA-4720475;KEGG: 00513+2.4.1.258 "N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG3 causes ALG3-CDG (CDG-1d)";"Various types of N-glycan biosynthesis" lcl|NW_020311988.1_prot_XP_020709739.1_20710 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" lcl|NW_020311432.1_prot_XP_012268728.1_8415 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" lcl|NW_020311962.1_prot_XP_012251846.1_13598 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311423.1_prot_XP_012251558.1_8159 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311957.1_prot_XP_012263404.1_12825 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311946.1_prot_XP_012268658.1_11907 17 MetaCyc: PWY-6545;MetaCyc: PWY-7221;MetaCyc: PWY-7184;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7227;MetaCyc: PWY-7198;MetaCyc: PWY-7176;MetaCyc: PWY-7210;MetaCyc: PWY-7187;MetaCyc: PWY-7205;MetaCyc: PWY-7220;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7226;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7224;MetaCyc: PWY-7197;MetaCyc: PWY-7222 "Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"CMP phosphorylation";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotide phosphorylation";"Guanosine deoxyribonucleotides de novo biosynthesis II" lcl|NW_020311962.1_prot_XP_012251892.1_13604 3 Reactome: R-HSA-430039;Reactome: R-HSA-450513;Reactome: R-HSA-450385 "mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" lcl|NW_020311976.1_prot_XP_012257908.1_17363 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" lcl|NW_020311298.1_prot_XP_012250597.1_1167 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311513.1_prot_XP_020711468.1_9850 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311974.1_prot_XP_012260189.1_16714 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311992.1_prot_XP_020711594.1_21210 2 Reactome: R-HSA-983168;Reactome: R-HSA-6798695 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation" lcl|NW_020311984.1_prot_XP_012254427.1_20068 6 Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-176974 "Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Unwinding of DNA" lcl|NW_020311334.1_prot_XP_012265869.1_4406 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311448.1_prot_XP_012252690.1_9003 1 Reactome: R-HSA-977347 "Serine biosynthesis" lcl|NW_020311945.1_prot_XP_012269649.1_11811 1 Reactome: R-HSA-4085001 "Sialic acid metabolism" lcl|NW_020311292.1_prot_XP_020706865.1_556 4 KEGG: 00030+1.1.1.49;MetaCyc: PWY-8004;MetaCyc: PWY-7268;KEGG: 00480+1.1.1.49 "Pentose phosphate pathway";"Entner-Doudoroff pathway I";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism" lcl|NW_020311292.1_prot_XP_020710262.1_686 4 Reactome: R-HSA-112308;Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-419037 "Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"NCAM1 interactions" lcl|NW_020311985.1_prot_XP_012265224.1_20228 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311325.1_prot_XP_020706309.1_3677 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" lcl|NW_020311356.1_prot_XP_012267062.1_5560 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" lcl|NW_020311975.1_prot_XP_012251937.1_17041 1 Reactome: R-HSA-433137 "Sodium-coupled sulphate, di- and tri-carboxylate transporters" lcl|NW_020311976.1_prot_XP_020707247.1_17239 2 Reactome: R-HSA-8866907;Reactome: R-HSA-8866904 "Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors" lcl|NW_020311513.1_prot_XP_012266132.1_9859 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" lcl|NW_020311980.1_prot_XP_012261234.1_18803 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311988.1_prot_XP_012269629.1_20589 1 Reactome: R-HSA-2514853 "Condensation of Prometaphase Chromosomes" lcl|NW_020311398.1_prot_XP_012260573.1_7384 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311995.1_prot_XP_020708308.1_22053 2 KEGG: 00071+2.3.1.21;MetaCyc: PWY-6111 "Fatty acid degradation";"Mitochondrial L-carnitine shuttle" lcl|NW_020311441.1_prot_XP_020706513.1_8889 3 Reactome: R-HSA-189451;KEGG: 00860+1.3.3.4;MetaCyc: PWY-7159 "Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)" lcl|NW_020311354.1_prot_XP_020709563.1_5489 2 Reactome: R-HSA-72702;Reactome: R-HSA-72706 "Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311966.1_prot_XP_012256448.1_14617 1 Reactome: R-HSA-4615885 "SUMOylation of DNA replication proteins" lcl|NW_020311979.1_prot_XP_020709812.1_18657 1 Reactome: R-HSA-2514859 "Inactivation, recovery and regulation of the phototransduction cascade" lcl|NW_020311365.1_prot_XP_020709373.1_5938 1 Reactome: R-HSA-71288 "Creatine metabolism" lcl|NW_020311926.1_prot_XP_012250743.1_10596 1 Reactome: R-HSA-418886 "Netrin mediated repulsion signals" lcl|NW_020311291.1_prot_XP_012259520.1_473 1 Reactome: R-HSA-1660499 "Synthesis of PIPs at the plasma membrane" lcl|NW_020311344.1_prot_XP_012250694.1_4893 3 Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154 "Smooth Muscle Contraction";"Purine metabolism";"Nitric oxide stimulates guanylate cyclase" lcl|NW_020311961.1_prot_XP_012262745.1_13354 4 Reactome: R-HSA-3000178;Reactome: R-HSA-3000170;Reactome: R-HSA-216083;Reactome: R-HSA-2129379 "ECM proteoglycans";"Syndecan interactions";"Integrin cell surface interactions";"Molecules associated with elastic fibres" lcl|NW_020311982.1_prot_XP_012258405.1_19200 2 Reactome: R-HSA-73980;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311966.1_prot_XP_012256806.1_15196 1 Reactome: R-HSA-947581 "Molybdenum cofactor biosynthesis" lcl|NW_020311978.1_prot_XP_012257936.1_18127 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311396.1_prot_XP_012269578.1_7273 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311967.1_prot_XP_012254281.1_15287 5 Reactome: R-HSA-379716;Reactome: R-HSA-2408522;Reactome: R-HSA-6782315;KEGG: 00970+6.1.1.15;Reactome: R-HSA-379726 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"tRNA modification in the nucleus and cytosol";"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" lcl|NW_020311917.1_prot_XP_012250969.1_10217 1 Reactome: R-HSA-9633012 "Response of EIF2AK4 (GCN2) to amino acid deficiency" lcl|NW_020311943.1_prot_XP_012255146.1_11634 3 KEGG: 00250+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00460+3.5.1.1 "Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism";"Cyanoamino acid metabolism" lcl|NW_020311332.1_prot_XP_012256841.1_4197 5 Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-5625740 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs" lcl|NW_020311359.1_prot_XP_020706674.1_5710 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311917.1_prot_XP_012250951.1_10230 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311940.1_prot_XP_020706960.1_11091 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311984.1_prot_XP_025602893.1_20149 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311327.1_prot_XP_020710468.1_3889 2 Reactome: R-HSA-8866423;Reactome: R-HSA-8963888 "VLDL assembly";"Chylomicron assembly" lcl|NW_020311316.1_prot_XP_020712355.1_3154 7 MetaCyc: PWY-6124;MetaCyc: PWY-7219;Reactome: R-HSA-73817;MetaCyc: PWY-6123;KEGG: 00230+4.3.2.2;KEGG: 00250+4.3.2.2;MetaCyc: PWY-7234 "Inosine-5'-phosphate biosynthesis II";"Adenosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Alanine, aspartate and glutamate metabolism";"Inosine-5'-phosphate biosynthesis III" lcl|NW_020311401.1_prot_XP_012254930.1_7583 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311401.1_prot_XP_012262255.2_7412 3 KEGG: 00790+3.4.19.9;Reactome: R-HSA-6798695;MetaCyc: PWY-2161B "Folate biosynthesis";"Neutrophil degranulation";"Glutamate removal from folates" lcl|NW_020311968.1_prot_XP_012265998.1_15469 3 KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1 "Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis" lcl|NW_020311971.1_prot_XP_020709645.1_15905 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" lcl|NW_020311993.1_prot_XP_020710188.1_21452 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311961.1_prot_XP_020710194.1_13425 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311407.1_prot_XP_012254814.1_7755 2 Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" lcl|NW_020311308.1_prot_XP_025603032.1_2229 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311349.1_prot_XP_012251125.1_5270 1 Reactome: R-HSA-350562 "Regulation of ornithine decarboxylase (ODC)" lcl|NW_020311559.1_prot_XP_025602219.1_10041 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311974.1_prot_XP_012260156.1_16764 27 Reactome: R-HSA-5619107;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-3108214;Reactome: R-HSA-3371453;Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-3301854;Reactome: R-HSA-159227;Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-4615885;Reactome: R-HSA-4085377;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-165054;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-4551638 "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"SUMOylation of DNA damage response and repair proteins";"Regulation of HSF1-mediated heat shock response";"HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP independent Mature mRNA";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"SUMOylation of DNA replication proteins";"SUMOylation of SUMOylation proteins";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"ISG15 antiviral mechanism";"Rev-mediated nuclear export of HIV RNA";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins" lcl|NW_020311995.1_prot_XP_012257271.1_22076 5 Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-917729 "Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)" lcl|NW_020311946.1_prot_XP_020712322.1_11889 16 Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-174154;Reactome: R-HSA-2559582;Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-176408;Reactome: R-HSA-179409 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Securin";"Senescence-Associated Secretory Phenotype (SASP)";"Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of APC/C activators between G1/S and early anaphase";"APC-Cdc20 mediated degradation of Nek2A" lcl|NW_020311940.1_prot_XP_020711231.1_11182 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311994.1_prot_XP_012267360.1_21605 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311955.1_prot_XP_012265385.1_12410 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" lcl|NW_020311399.1_prot_XP_012262342.1_7388 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311966.1_prot_XP_012256920.1_14697 6 Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" lcl|NW_020311959.1_prot_XP_012262293.1_13086 3 Reactome: R-HSA-110314;Reactome: R-HSA-5689880;Reactome: R-HSA-6783310 "Recognition of DNA damage by PCNA-containing replication complex";"Ub-specific processing proteases";"Fanconi Anemia Pathway" lcl|NW_020311985.1_prot_XP_012265227.1_20231 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311966.1_prot_XP_020708293.1_15194 4 Reactome: R-HSA-947581;MetaCyc: PWY-7887;MetaCyc: PWY-6823;KEGG: 00790+2.8.1.12 "Molybdenum cofactor biosynthesis";"Protein SAMPylation and SAMP-mediated thiolation";"Molybdenum cofactor biosynthesis";"Folate biosynthesis" lcl|NW_020311982.1_prot_XP_012258412.1_19295 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" lcl|NW_020311981.1_prot_XP_012257466.1_18972 3 Reactome: R-HSA-5696400;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135 "Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER" lcl|NW_020311985.1_prot_XP_012253833.1_20296 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311334.1_prot_XP_012265853.2_4359 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311302.1_prot_XP_012264553.1_1678 3 MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783 "Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis" lcl|NW_020311393.1_prot_XP_020711298.1_7202 10 MetaCyc: PWY-1861;Reactome: R-HSA-70171;MetaCyc: PWY-5484;KEGG: 00030+2.7.1.11;KEGG: 00052+2.7.1.11;MetaCyc: PWY-7385;KEGG: 00680+2.7.1.11;KEGG: 00051+2.7.1.11;MetaCyc: PWY-1042;KEGG: 00010+2.7.1.11 "Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Galactose metabolism";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism";"Fructose and mannose metabolism";"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis" lcl|NW_020311334.1_prot_XP_012265864.1_4401 2 Reactome: R-HSA-426486;Reactome: R-HSA-203927 "Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis" lcl|NW_020311367.1_prot_XP_012258967.1_6128 14 Reactome: R-HSA-71403;KEGG: 00650+1.3.5.1;MetaCyc: PWY-3781;Reactome: R-HSA-611105;MetaCyc: PWY-7279;KEGG: 00020+1.3.5.1;KEGG: 00720+1.3.5.1;KEGG: 00190+1.3.5.1;MetaCyc: PWY-6728;MetaCyc: PWY-5690;MetaCyc: PWY-4302;MetaCyc: PWY-561;MetaCyc: PWY-6969;MetaCyc: PWY-7254 "Citric acid cycle (TCA cycle)";"Butanoate metabolism";"Aerobic respiration I (cytochrome c)";"Respiratory electron transport";"Aerobic respiration II (cytochrome c) (yeast)";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Oxidative phosphorylation";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle VII (acetate-producers)" lcl|NW_020311958.1_prot_XP_012255603.1_12934 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311408.1_prot_XP_020710016.1_7807 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311982.1_prot_XP_012258470.1_19231 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311432.1_prot_XP_012268717.1_8449 4 Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556 "Transferrin endocytosis and recycling";"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes" lcl|NW_020311994.1_prot_XP_012267466.1_21793 2 KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753 "Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism" lcl|NW_020311940.1_prot_XP_012265528.1_11339 5 Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-389357;Reactome: R-HSA-1257604 "Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling" lcl|NW_020311985.1_prot_XP_020711110.1_20255 6 MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782 "Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311362.1_prot_XP_020710999.1_5876 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311375.1_prot_XP_020708209.1_6536 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311441.1_prot_XP_012251241.1_8883 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311991.1_prot_XP_012269773.1_20875 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311974.1_prot_XP_020709397.1_16793 10 MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-7587;MetaCyc: PWY-5667;Reactome: R-HSA-1483166;KEGG: 00561+2.3.1.15;MetaCyc: PWY-8055;MetaCyc: PWY-8053;MetaCyc: PWY-7411;KEGG: 00564+2.3.1.15 "Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"Phosphatidate biosynthesis (yeast)";"Glycerophospholipid metabolism" lcl|NW_020311978.1_prot_XP_012258042.1_18284 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311976.1_prot_XP_012257086.1_17447 6 Reactome: R-HSA-390450;Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-5620922;Reactome: R-HSA-390471 "Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"BBSome-mediated cargo-targeting to cilium";"Association of TriC/CCT with target proteins during biosynthesis" lcl|NW_020311976.1_prot_XP_020708441.1_17452 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311334.1_prot_XP_012265861.1_4391 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311989.1_prot_XP_012263226.1_20777 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311925.1_prot_XP_012252600.1_10536 4 Reactome: R-HSA-5358346;Reactome: R-HSA-382556;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895 "Hedgehog ligand biogenesis";"ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis" lcl|NW_020311966.1_prot_XP_012256650.1_14692 1 KEGG: 00450+1.8.1.9 "Selenocompound metabolism" lcl|NW_020311343.1_prot_XP_012258466.1_4836 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311984.1_prot_XP_012254587.1_20063 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" lcl|NW_020311970.1_prot_XP_012267423.1_15804 6 Reactome: R-HSA-1655829;Reactome: R-HSA-381033;Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-8963889;Reactome: R-HSA-8874211 "Regulation of cholesterol biosynthesis by SREBP (SREBF)";"ATF6 (ATF6-alpha) activates chaperones";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Assembly of active LPL and LIPC lipase complexes";"CREB3 factors activate genes" lcl|NW_020311316.1_prot_XP_012269020.1_3151 7 MetaCyc: PWY-6124;MetaCyc: PWY-7219;Reactome: R-HSA-73817;MetaCyc: PWY-6123;KEGG: 00250+4.3.2.2;KEGG: 00230+4.3.2.2;MetaCyc: PWY-7234 "Inosine-5'-phosphate biosynthesis II";"Adenosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis I";"Alanine, aspartate and glutamate metabolism";"Purine metabolism";"Inosine-5'-phosphate biosynthesis III" lcl|NW_020311313.1_prot_XP_012261852.1_2853 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311978.1_prot_XP_012257960.1_18237 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311994.1_prot_XP_012267524.1_21681 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311393.1_prot_XP_020711292.1_7213 5 Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-5625740;Reactome: R-HSA-111447;Reactome: R-HSA-5628897 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate PKNs";"Activation of BAD and translocation to mitochondria";"TP53 Regulates Metabolic Genes" lcl|NW_020311513.1_prot_XP_012266149.1_9829 6 MetaCyc: PWY-6118;MetaCyc: PWY-6952;Reactome: R-HSA-1483166;MetaCyc: PWY-4261;Reactome: R-HSA-163560;KEGG: 00564+1.1.5.3 "Glycerol-3-phosphate shuttle";"Glycerophosphodiester degradation";"Synthesis of PA";"Glycerol degradation I";"Triglyceride catabolism";"Glycerophospholipid metabolism" lcl|NW_020311982.1_prot_XP_020708736.1_19251 11 KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-171007;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-450302;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-2559580;Reactome: R-HSA-4420097 "Relaxin signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"p38MAPK events";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"activated TAK1 mediates p38 MAPK activation";"Human papillomavirus infection";"Human cytomegalovirus infection";"Oxidative Stress Induced Senescence";"VEGFA-VEGFR2 Pathway" lcl|NW_020311349.1_prot_XP_020706495.1_5229 7 Reactome: R-HSA-5628897;KEGG: 00471+3.5.1.2;Reactome: R-HSA-210500;KEGG: 00250+3.5.1.2;MetaCyc: PWY-5921;Reactome: R-HSA-8964539;KEGG: 00220+3.5.1.2 "TP53 Regulates Metabolic Genes";"D-Glutamine and D-glutamate metabolism";"Glutamate Neurotransmitter Release Cycle";"Alanine, aspartate and glutamate metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate and glutamine metabolism";"Arginine biosynthesis" lcl|NW_020311343.1_prot_XP_012258279.1_4791 14 Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167243 "Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery" lcl|NW_020311372.1_prot_XP_012268446.1_6299 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311401.1_prot_XP_012254765.1_7466 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" lcl|NW_020311984.1_prot_XP_012267710.1_20138 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311992.1_prot_XP_012266288.1_21031 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311306.1_prot_XP_012251697.1_2135 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311400.1_prot_XP_012264255.1_7398 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311940.1_prot_XP_020711270.1_11346 3 MetaCyc: PWY-6317;KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3 "D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Glycolysis / Gluconeogenesis" lcl|NW_020311308.1_prot_XP_012253331.1_2231 3 MetaCyc: PWY-7799;MetaCyc: PWY-7800;Reactome: R-HSA-2514859 "Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway";"Inactivation, recovery and regulation of the phototransduction cascade" lcl|NW_020311401.1_prot_XP_012254951.1_7594 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311539.1_prot_XP_012262369.1_9989 4 Reactome: R-HSA-1632852;Reactome: R-HSA-936440;Reactome: R-HSA-8934903;Reactome: R-HSA-5205685 "Macroautophagy";"Negative regulators of DDX58/IFIH1 signaling";"Receptor Mediated Mitophagy";"Pink/Parkin Mediated Mitophagy" lcl|NW_020311315.1_prot_XP_012265204.1_3132 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311513.1_prot_XP_012266190.1_9894 6 MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578;KEGG: 00510+2.4.1.143;KEGG: 00513+2.4.1.143;Reactome: R-HSA-4793952 "Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)" lcl|NW_020311343.1_prot_XP_012258138.1_4770 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" lcl|NW_020311975.1_prot_XP_012252651.1_17101 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311965.1_prot_XP_012260277.1_14053 57 Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-187577;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-6798695;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-174113;Reactome: R-HSA-202424 "Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RAS by GAPs";"G2/M Checkpoints";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"SCF(Skp2)-mediated degradation of p27/p21";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Neutrophil degranulation";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling" lcl|NW_020311957.1_prot_XP_025602441.1_12751 4 KEGG: 00983+6.3.5.2;Reactome: R-HSA-73817;MetaCyc: PWY-7221;KEGG: 00230+6.3.5.2 "Drug metabolism - other enzymes";"Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311973.1_prot_XP_012258752.1_16494 2 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase" lcl|NW_020311966.1_prot_XP_012251733.1_14583 5 Reactome: R-HSA-389661;Reactome: R-HSA-70688;KEGG: 00330+1.2.1.88;MetaCyc: PWY-6853;KEGG: 00250+1.2.1.88 "Glyoxylate metabolism and glycine degradation";"Proline catabolism";"Arginine and proline metabolism";"Ethylene biosynthesis II (microbes)";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311982.1_prot_XP_012264628.1_19388 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311964.1_prot_XP_012261994.1_13964 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" lcl|NW_020311320.1_prot_XP_020709104.1_3349 2 Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13 "Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system" lcl|NW_020311983.1_prot_XP_012267194.1_19481 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311983.1_prot_XP_012268314.1_19611 1 Reactome: R-HSA-2514853 "Condensation of Prometaphase Chromosomes" lcl|NW_020311987.1_prot_XP_020712073.1_20420 3 KEGG: 00790+2.8.1.9;MetaCyc: PWY-5963;Reactome: R-HSA-947581 "Folate biosynthesis";"Thio-molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis" lcl|NW_020311433.1_prot_XP_020710646.1_8608 5 MetaCyc: PWY-8013;KEGG: 00520+2.6.1.16;Reactome: R-HSA-446210;KEGG: 00250+2.6.1.16;MetaCyc: PWY-6749 "UDP-N-acetyl-D-galactosamine biosynthesis III";"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"Alanine, aspartate and glutamate metabolism";"CMP-legionaminate biosynthesis I" lcl|NW_020311329.1_prot_XP_012258975.1_3937 4 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-1912420;Reactome: R-HSA-936837 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi";"Ion transport by P-type ATPases" lcl|NW_020311311.1_prot_XP_012250901.1_2456 6 Reactome: R-HSA-427359;Reactome: R-HSA-73772;Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-73762 "SIRT1 negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation" lcl|NW_020311977.1_prot_XP_012253878.1_17587 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311349.1_prot_XP_020706482.1_5264 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311304.1_prot_XP_012259543.1_1786 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311397.1_prot_XP_012258194.1_7296 3 Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-936837 "Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Ion transport by P-type ATPases" lcl|NW_020311439.1_prot_XP_012264166.1_8826 14 MetaCyc: PWY-7619;MetaCyc: PWY-5972;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-7724 "Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)" lcl|NW_020311315.1_prot_XP_020711113.1_3115 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311333.1_prot_XP_012256068.1_4293 4 Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" lcl|NW_020311353.1_prot_XP_025601837.1_5394 13 Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689 "Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits" lcl|NW_020311397.1_prot_XP_020707297.1_7350 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311475.1_prot_XP_020707130.1_9385 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311296.1_prot_XP_020711236.1_1028 1 Reactome: R-HSA-428890 "Role of ABL in ROBO-SLIT signaling" lcl|NW_020311582.1_prot_XP_025602223.1_10055 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311447.1_prot_XP_025602124.1_8966 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311362.1_prot_XP_012264952.1_5867 22 MetaCyc: PWY-6958;MetaCyc: PWY-5353;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7592;MetaCyc: PWY-7035;MetaCyc: PWY-7053;MetaCyc: PWY-7606;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-5080;MetaCyc: PWY-7049;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-6433;Reactome: R-HSA-75876;MetaCyc: PWY-7727;MetaCyc: PWY-7724;MetaCyc: PWY-7726;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7728 "Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Synthesis of very long-chain fatty acyl-CoAs";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid elongation";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)" lcl|NW_020311977.1_prot_XP_020710542.1_18032 14 MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7725;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-7036;KEGG: 00062+2.3.1.199 "(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation" lcl|NW_020311982.1_prot_XP_012258417.1_19195 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" lcl|NW_020311289.1_prot_XP_012253837.1_390 2 Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" lcl|NW_020311362.1_prot_XP_012264926.1_5847 7 MetaCyc: PWY-8043;Reactome: R-HSA-5578999;MetaCyc: PWY-7255;KEGG: 00270+6.3.2.2;KEGG: 00480+6.3.2.2;MetaCyc: PWY-6840;Reactome: R-HSA-174403 "Ophthalmate biosynthesis";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Ergothioneine biosynthesis I (bacteria)";"Cysteine and methionine metabolism";"Glutathione metabolism";"Homoglutathione biosynthesis";"Glutathione synthesis and recycling" lcl|NW_020311989.1_prot_XP_012263274.1_20745 2 Reactome: R-HSA-9610379;Reactome: R-HSA-917729 "HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)" lcl|NW_020311513.1_prot_XP_012266162.1_9808 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311995.1_prot_XP_012256948.1_22061 27 Reactome: R-HSA-5619107;Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-159230;Reactome: R-HSA-168333;Reactome: R-HSA-3301854;Reactome: R-HSA-159227;Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-4085377;Reactome: R-HSA-4615885;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-6784531;Reactome: R-HSA-4551638 "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP Dependant Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP independent Mature mRNA";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"SUMOylation of SUMOylation proteins";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"HCMV Early Events";"ISG15 antiviral mechanism";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"tRNA processing in the nucleus";"SUMOylation of chromatin organization proteins" lcl|NW_020311286.1_prot_XP_012256430.1_236 1 Reactome: R-HSA-427601 "Multifunctional anion exchangers" lcl|NW_020311438.1_prot_XP_012269002.1_8802 4 MetaCyc: PWY-7805;Reactome: R-HSA-71737;MetaCyc: PWY-7807;KEGG: 00190+3.6.1.1 "(aminomethyl)phosphonate degradation";"Pyrophosphate hydrolysis";"Glyphosate degradation III";"Oxidative phosphorylation" lcl|NW_020311953.1_prot_XP_012260519.1_12257 6 KEGG: 00270+2.6.1.52;KEGG: 00260+2.6.1.52;Reactome: R-HSA-977347;KEGG: 00680+2.6.1.52;MetaCyc: PWY-8010;KEGG: 00750+2.6.1.52 "Cysteine and methionine metabolism";"Glycine, serine and threonine metabolism";"Serine biosynthesis";"Methane metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Vitamin B6 metabolism" lcl|NW_020311941.1_prot_XP_012253276.1_11429 13 Reactome: R-HSA-937072;Reactome: R-HSA-5607764;Reactome: R-HSA-450302;Reactome: R-HSA-2871837;Reactome: R-HSA-445989;Reactome: R-HSA-168638;Reactome: R-HSA-975163;Reactome: R-HSA-5357956;Reactome: R-HSA-9014325;Reactome: R-HSA-9645460;Reactome: R-HSA-937042;Reactome: R-HSA-9020702;Reactome: R-HSA-450321 "TRAF6-mediated induction of TAK1 complex within TLR4 complex";"CLEC7A (Dectin-1) signaling";"activated TAK1 mediates p38 MAPK activation";"FCERI mediated NF-kB activation";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"NOD1/2 Signaling Pathway";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TNFR1-induced NFkappaB signaling pathway";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Alpha-protein kinase 1 signaling pathway";"IRAK2 mediated activation of TAK1 complex";"Interleukin-1 signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" lcl|NW_020311995.1_prot_XP_012256814.1_21929 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311966.1_prot_XP_020706991.1_14415 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311968.1_prot_XP_012253070.1_15458 3 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" lcl|NW_020311313.1_prot_XP_012261849.1_2850 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311299.1_prot_XP_020710416.1_1477 1 KEGG: 00970+6.1.1.21 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311940.1_prot_XP_020711242.1_11336 5 Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757 "Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation" lcl|NW_020311984.1_prot_XP_012267729.1_20131 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311312.1_prot_XP_012266893.1_2694 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311965.1_prot_XP_020709474.1_14180 7 Reactome: R-HSA-77111;KEGG: 00281+4.1.3.4;KEGG: 00280+4.1.3.4;KEGG: 00650+4.1.3.4;MetaCyc: PWY-5074;Reactome: R-HSA-9033241;KEGG: 00072+4.1.3.4 "Synthesis of Ketone Bodies";"Geraniol degradation";"Valine, leucine and isoleucine degradation";"Butanoate metabolism";"Mevalonate degradation";"Peroxisomal protein import";"Synthesis and degradation of ketone bodies" lcl|NW_020311995.1_prot_XP_012256978.1_21987 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" lcl|NW_020311341.1_prot_XP_012257996.1_4700 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311370.1_prot_XP_020710068.1_6266 3 KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16 "Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer" lcl|NW_020311424.1_prot_XP_012255426.1_8202 2 Reactome: R-HSA-1268020;Reactome: R-HSA-5205685 "Mitochondrial protein import";"Pink/Parkin Mediated Mitophagy" lcl|NW_020311971.1_prot_XP_012260801.1_15851 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311971.1_prot_XP_012260955.1_15990 42 MetaCyc: PWY-6583;MetaCyc: PWY-6945;MetaCyc: PWY-5138;MetaCyc: PWY-7778;MetaCyc: PWY-5789;MetaCyc: PWY-7779;MetaCyc: PWY-6944;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-7094;KEGG: 00071+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-7606;MetaCyc: PWY-1361;MetaCyc: PWY-7401;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;MetaCyc: PWY-7007;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00623+1.1.1.35;KEGG: 00903+4.2.1.17;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;MetaCyc: PWY-7726;MetaCyc: PWY-6883;MetaCyc: PWY-7654;KEGG: 00592+4.2.1.17;MetaCyc: PWY-5136;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;KEGG: 00410+4.2.1.17;MetaCyc: PWY-7656;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-6863;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;MetaCyc: PWY-7216;MetaCyc: PWY-5109 "Pyruvate fermentation to butanol I";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Fatty acid beta-oxidation IV (unsaturated, even number)";"2-methylpropene degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Methyl tert-butyl ether degradation";"Androstenedione degradation";"Caprolactam degradation";"Fatty acid salvage";"Fatty acid degradation";"Aminobenzoate degradation";"Carbon fixation pathways in prokaryotes";"Fatty acid elongation";"Phenylalanine metabolism";"Fatty acid degradation";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Benzoyl-coa degradation I (aerobic)";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Valine, leucine and isoleucine degradation";"Propanoate metabolism";"Methyl ketone biosynthesis (engineered)";"Butanoate metabolism";"Toluene degradation";"Limonene and pinene degradation";"Benzoate degradation";"Tryptophan metabolism";"4-hydroxybenzoate biosynthesis III (plants)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Pyruvate fermentation to butanol II (engineered)";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Lysine degradation";"Glutaryl-coa degradation";"beta-Alanine metabolism";"Spodoptera littoralis pheromone biosynthesis";"Geraniol degradation";"Pyruvate fermentation to hexanol (engineered)";"Butanoate metabolism";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Fermentation to 2-methylbutanoate" lcl|NW_020311959.1_prot_XP_012259598.1_13151 1 Reactome: R-HSA-71288 "Creatine metabolism" lcl|NW_020311978.1_prot_XP_020708562.1_18099 1 Reactome: R-HSA-70171 "Glycolysis" lcl|NW_020311513.1_prot_XP_012266124.1_9843 4 KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943 "Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates" lcl|NW_020311513.1_prot_XP_012266122.1_9841 4 KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3 "Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311959.1_prot_XP_012254237.1_13212 1 Reactome: R-HSA-525793 "Myogenesis" lcl|NW_020311418.1_prot_XP_012261021.1_8029 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311984.1_prot_XP_012254495.1_19920 12 MetaCyc: PWY-7817;Reactome: R-HSA-3322077;KEGG: 00520+2.7.7.9;MetaCyc: PWY-7238;KEGG: 00561+2.7.7.9;KEGG: 00040+2.7.7.9;MetaCyc: PWY-7343;MetaCyc: PWY-3801;KEGG: 00052+2.7.7.9;KEGG: 00500+2.7.7.9;MetaCyc: PWY-6527;Reactome: R-HSA-173599 "Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycogen synthesis";"Amino sugar and nucleotide sugar metabolism";"Sucrose biosynthesis II";"Glycerolipid metabolism";"Pentose and glucuronate interconversions";"UDP-alpha-D-glucose biosynthesis I";"Sucrose degradation II (sucrose synthase)";"Galactose metabolism";"Starch and sucrose metabolism";"Stachyose degradation";"Formation of the active cofactor, UDP-glucuronate" lcl|NW_020311982.1_prot_XP_012258440.1_19271 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311965.1_prot_XP_012260192.1_14223 13 Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957 "L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311361.1_prot_XP_012261507.1_5788 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311992.1_prot_XP_012266514.1_21166 4 Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942 "Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)" lcl|NW_020311984.1_prot_XP_012254568.1_19990 1 Reactome: R-HSA-901032 "ER Quality Control Compartment (ERQC)" lcl|NW_020311302.1_prot_XP_020710884.1_1699 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311965.1_prot_XP_012260319.1_14060 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311304.1_prot_XP_012260907.1_1770 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311977.1_prot_XP_012263848.1_17743 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" lcl|NW_020311978.1_prot_XP_012257723.1_18306 57 Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-5687128;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5689880;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-6798695;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902 "Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"G2/M Checkpoints";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"MAPK6/MAPK4 signaling";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Ub-specific processing proteases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Neutrophil degranulation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity" lcl|NW_020311953.1_prot_XP_012260518.1_12256 6 MetaCyc: PWY-8010;KEGG: 00750+2.6.1.52;KEGG: 00260+2.6.1.52;KEGG: 00270+2.6.1.52;KEGG: 00680+2.6.1.52;Reactome: R-HSA-977347 "L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Vitamin B6 metabolism";"Glycine, serine and threonine metabolism";"Cysteine and methionine metabolism";"Methane metabolism";"Serine biosynthesis" lcl|NW_020311981.1_prot_XP_012257551.1_19148 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311915.1_prot_XP_012262415.1_10158 24 Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-5617833;Reactome: R-HSA-3371497;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-6807878;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-68877 "The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Cilium Assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"COPI-mediated anterograde transport";"Aggrephagy";"Separation of Sister Chromatids";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"RHO GTPases Activate Formins";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Mitotic Prometaphase" lcl|NW_020311934.1_prot_XP_012254915.1_10896 13 Reactome: R-HSA-8948216;Reactome: R-HSA-2243919;Reactome: R-HSA-186797;Reactome: R-HSA-3000178;Reactome: R-HSA-2214320;Reactome: R-HSA-216083;Reactome: R-HSA-1650814;Reactome: R-HSA-3000157;Reactome: R-HSA-1474244;Reactome: R-HSA-1442490;Reactome: R-HSA-2022090;Reactome: R-HSA-3000171;Reactome: R-HSA-419037 "Collagen chain trimerization";"Crosslinking of collagen fibrils";"Signaling by PDGF";"ECM proteoglycans";"Anchoring fibril formation";"Integrin cell surface interactions";"Collagen biosynthesis and modifying enzymes";"Laminin interactions";"Extracellular matrix organization";"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures";"Non-integrin membrane-ECM interactions";"NCAM1 interactions" lcl|NW_020311356.1_prot_XP_012267059.1_5563 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" lcl|NW_020311981.1_prot_XP_012257370.1_19175 2 Reactome: R-HSA-1660662;Reactome: R-HSA-390471 "Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis" lcl|NW_020311976.1_prot_XP_012256939.2_17393 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311980.1_prot_XP_012254909.1_18711 9 Reactome: R-HSA-110330;Reactome: R-HSA-110331;Reactome: R-HSA-9656256;Reactome: R-HSA-110328;Reactome: R-HSA-110329;Reactome: R-HSA-9657050;Reactome: R-HSA-9656255;Reactome: R-HSA-110357;Reactome: R-HSA-5649702 "Recognition and association of DNA glycosylase with site containing an affected purine";"Cleavage of the damaged purine";"Defective OGG1 Substrate Processing";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged pyrimidine";"Defective OGG1 Localization";"Defective OGG1 Substrate Binding";"Displacement of DNA glycosylase by APEX1";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" lcl|NW_020311984.1_prot_XP_012254606.1_19916 10 Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167161;Reactome: R-HSA-3214847;Reactome: R-HSA-6804756;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-167172 "RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HIV Transcription Initiation";"HATs acetylate histones";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome" lcl|NW_020311286.1_prot_XP_020708395.1_224 5 KEGG: 00520+2.7.1.6;MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6317;MetaCyc: PWY-6527 "Amino sugar and nucleotide sugar metabolism";"D-galactose detoxification";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation" lcl|NW_020311308.1_prot_XP_020710841.1_2176 12 Reactome: R-HSA-447038;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-8849932;MetaCyc: PWY-7221;Reactome: R-HSA-9617324;KEGG: 00230+2.7.4.8;Reactome: R-HSA-451308;Reactome: R-HSA-442982;Reactome: R-HSA-438066;Reactome: R-HSA-399719;Reactome: R-HSA-9620244 "NrCAM interactions";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"Synaptic adhesion-like molecules";"Guanosine ribonucleotides de novo biosynthesis";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Purine metabolism";"Activation of Ca-permeable Kainate Receptor";"Ras activation upon Ca2+ influx through NMDA receptor";"Unblocking of NMDA receptors, glutamate binding and activation";"Trafficking of AMPA receptors";"Long-term potentiation" lcl|NW_020311436.1_prot_XP_012258384.1_8752 7 MetaCyc: PWY-7790;Reactome: R-HSA-500753;KEGG: 00240+4.1.1.23;MetaCyc: PWY-5686;KEGG: 00983+2.4.2.10;KEGG: 00240+2.4.2.10;MetaCyc: PWY-7791 "UMP biosynthesis II";"Pyrimidine biosynthesis";"Pyrimidine metabolism";"UMP biosynthesis I";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"UMP biosynthesis III" lcl|NW_020311974.1_prot_XP_012260108.1_16862 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311339.1_prot_XP_020707697.1_4604 2 Reactome: R-HSA-6783310;Reactome: R-HSA-6796648 "Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes" lcl|NW_020311401.1_prot_XP_012255235.1_7482 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" lcl|NW_020311943.1_prot_XP_012255011.1_11721 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311432.1_prot_XP_012268704.1_8459 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311401.1_prot_XP_012255086.1_7492 52 Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-73863;Reactome: R-HSA-6796648;Reactome: R-HSA-6807505;Reactome: R-HSA-76061;Reactome: R-HSA-167242;Reactome: R-HSA-73762;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-76042;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-76066;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-112382;Reactome: R-HSA-5250924;Reactome: R-HSA-1834949;Reactome: R-HSA-73780;Reactome: R-HSA-167287;Reactome: R-HSA-5617472;Reactome: R-HSA-167243;Reactome: R-HSA-749476;Reactome: R-HSA-73776;Reactome: R-HSA-167238;Reactome: R-HSA-5578749;Reactome: R-HSA-167162;Reactome: R-HSA-72086;Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-5601884;Reactome: R-HSA-73779;Reactome: R-HSA-6803529;Reactome: R-HSA-6781827;Reactome: R-HSA-167161;Reactome: R-HSA-203927;Reactome: R-HSA-73772;Reactome: R-HSA-72203;Reactome: R-HSA-167152;Reactome: R-HSA-72165;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-77075;Reactome: R-HSA-8851708 "NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase I Transcription Termination";"TP53 Regulates Transcription of DNA Repair Genes";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase I Transcription Initiation";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of RNA Pol II elongation complex";"B-WICH complex positively regulates rRNA expression";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Chain Elongation";"HIV elongation arrest and recovery";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase II Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"Transcriptional regulation by small RNAs";"RNA Polymerase II HIV Promoter Escape";"mRNA Capping";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"FGFR2 alternative splicing";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"HIV Transcription Initiation";"MicroRNA (miRNA) biogenesis";"RNA Polymerase I Promoter Escape";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Pol II CTD phosphorylation and interaction with CE";"Signaling by FGFR2 IIIa TM" lcl|NW_020311292.1_prot_XP_012252574.1_630 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311955.1_prot_XP_012265399.1_12511 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311448.1_prot_XP_020706915.1_9022 3 MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783 "Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis" lcl|NW_020311983.1_prot_XP_012267174.1_19524 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311961.1_prot_XP_020710216.1_13352 4 MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943 "Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates" lcl|NW_020311966.1_prot_XP_012256511.1_14758 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311961.1_prot_XP_020710226.1_13517 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311419.1_prot_XP_012254064.1_8070 1 Reactome: R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" lcl|NW_020311933.1_prot_XP_012258793.1_10737 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" lcl|NW_020311962.1_prot_XP_012252108.1_13549 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311959.1_prot_XP_012262297.1_13094 5 MetaCyc: PWY-5083;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7269 "NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)" lcl|NW_020311332.1_prot_XP_012256550.1_4190 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311955.1_prot_XP_020711182.1_12508 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311989.1_prot_XP_012263198.1_20757 1 Reactome: R-HSA-6804760 "Regulation of TP53 Activity through Methylation" lcl|NW_020311981.1_prot_XP_012257527.1_19017 4 Reactome: R-HSA-2173788;Reactome: R-HSA-2173789;Reactome: R-HSA-3656532;Reactome: R-HSA-3304356 "Downregulation of TGF-beta receptor signaling";"TGF-beta receptor signaling activates SMADs";"TGFBR1 KD Mutants in Cancer";"SMAD2/3 Phosphorylation Motif Mutants in Cancer" lcl|NW_020311327.1_prot_XP_012263457.1_3872 2 Reactome: R-HSA-877300;Reactome: R-HSA-2132295 "Interferon gamma signaling";"MHC class II antigen presentation" lcl|NW_020311983.1_prot_XP_020707937.1_19732 2 Reactome: R-HSA-2564830;Reactome: R-HSA-83936 "Cytosolic iron-sulfur cluster assembly";"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" lcl|NW_020311959.1_prot_XP_012262298.1_13095 5 MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7268 "NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)" lcl|NW_020311994.1_prot_XP_020711895.1_21536 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311290.1_prot_XP_025601781.1_420 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311983.1_prot_XP_012267210.1_19489 3 MetaCyc: PWY-7511;Reactome: R-HSA-1358803;Reactome: R-HSA-983168 "Protein ubiquitination";"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311401.1_prot_XP_020707784.1_7504 4 Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-427389 "Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" lcl|NW_020311392.1_prot_XP_020706411.1_7085 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311374.1_prot_XP_012264581.1_6524 30 Reactome: R-HSA-180534;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-2644606;Reactome: R-HSA-1170546;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-2894862;Reactome: R-HSA-400253;Reactome: R-HSA-2644607;Reactome: R-HSA-5676590;Reactome: R-HSA-2122947;Reactome: R-HSA-5610785;Reactome: R-HSA-9020702;Reactome: R-HSA-5610783;Reactome: R-HSA-5607764;Reactome: R-HSA-5684264;Reactome: R-HSA-5607761;Reactome: R-HSA-2565942;Reactome: R-HSA-917937;Reactome: R-HSA-68949;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-9604323;Reactome: R-HSA-69231;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-8951664 "Vpu mediated degradation of CD4";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Prolactin receptor signaling";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Circadian Clock";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"NIK-->noncanonical NF-kB signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"GLI3 is processed to GLI3R by the proteasome";"Interleukin-1 signaling";"Degradation of GLI2 by the proteasome";"CLEC7A (Dectin-1) signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of PLK1 Activity at G2/M Transition";"Iron uptake and transport";"Orc1 removal from chromatin";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Negative regulation of NOTCH4 signaling";"Cyclin D associated events in G1";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Neddylation" lcl|NW_020311441.1_prot_XP_012251245.1_8891 3 Reactome: R-HSA-189451;MetaCyc: PWY-7159;KEGG: 00860+1.3.3.4 "Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism" lcl|NW_020311969.1_prot_XP_012264788.1_15542 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311955.1_prot_XP_012265331.1_12371 13 Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557 "Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis" lcl|NW_020311946.1_prot_XP_025602390.1_11943 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311977.1_prot_XP_012253809.1_17498 6 Reactome: R-HSA-5685938;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756 "HDR through Single Strand Annealing (SSA)";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation" lcl|NW_020311920.1_prot_XP_025602268.1_10502 5 Reactome: R-HSA-5696397;Reactome: R-HSA-5685939;Reactome: R-HSA-110381;Reactome: R-HSA-5649702;Reactome: R-HSA-6782210 "Gap-filling DNA repair synthesis and ligation in GG-NER";"HDR through MMEJ (alt-NHEJ)";"Resolution of AP sites via the single-nucleotide replacement pathway";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER" lcl|NW_020311448.1_prot_XP_020706927.1_9002 1 Reactome: R-HSA-977347 "Serine biosynthesis" lcl|NW_020311436.1_prot_XP_012258217.1_8779 3 KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596 "Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I" lcl|NW_020311312.1_prot_XP_012266794.1_2608 5 Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-917977 "ROS and RNS production in phagocytes";"Ion channel transport";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Transferrin endocytosis and recycling" lcl|NW_020311973.1_prot_XP_020708895.1_16587 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" lcl|NW_020311995.1_prot_XP_012257174.1_21889 9 Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-167161 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation" lcl|NW_020311966.1_prot_XP_012256914.1_14717 2 Reactome: R-HSA-429958;Reactome: R-HSA-390471 "mRNA decay by 3' to 5' exoribonuclease";"Association of TriC/CCT with target proteins during biosynthesis" lcl|NW_020311329.1_prot_XP_020708994.1_3939 4 Reactome: R-HSA-1912420;Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Pre-NOTCH Processing in Golgi";"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311967.1_prot_XP_020707513.1_15283 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311334.1_prot_XP_020711365.1_4382 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311948.1_prot_XP_012253462.1_12050 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311312.1_prot_XP_012266746.1_2580 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311313.1_prot_XP_012261783.1_3066 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311995.1_prot_XP_012256973.1_21991 5 Reactome: R-HSA-5693571;Reactome: R-HSA-5693565;Reactome: R-HSA-69473;Reactome: R-HSA-3232118;Reactome: R-HSA-5693607 "Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"G2/M DNA damage checkpoint";"SUMOylation of transcription factors";"Processing of DNA double-strand break ends" lcl|NW_020311356.1_prot_XP_012267093.1_5551 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" lcl|NW_020311436.1_prot_XP_012258373.1_8765 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311940.1_prot_XP_012265516.1_11289 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" lcl|NW_020311377.1_prot_XP_012260424.1_6611 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311980.1_prot_XP_012254910.1_18709 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311977.1_prot_XP_012264037.1_17890 6 MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733 "Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis" lcl|NW_020311449.1_prot_XP_025602127.1_9033 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311966.1_prot_XP_012256999.1_15089 8 Reactome: R-HSA-3371571;Reactome: R-HSA-1632852;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-8943724 "HSF1-dependent transactivation";"Macroautophagy";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Regulation of PTEN gene transcription" lcl|NW_020311346.1_prot_XP_020710328.1_4998 2 Reactome: R-HSA-419812;Reactome: R-HSA-418555 "Calcitonin-like ligand receptors";"G alpha (s) signalling events" lcl|NW_020311965.1_prot_XP_012259998.1_14267 1 Reactome: R-HSA-8849175 "Threonine catabolism" lcl|NW_020311360.1_prot_XP_025601872.1_5778 1 Reactome: R-HSA-5628897 "TP53 Regulates Metabolic Genes" lcl|NW_020311974.1_prot_XP_020709406.1_16868 1 Reactome: R-HSA-446210 "Synthesis of UDP-N-acetyl-glucosamine" lcl|NW_020311407.1_prot_XP_012254807.1_7772 20 MetaCyc: PWY-7338;MetaCyc: PWY-7574;MetaCyc: PWY-7007;MetaCyc: PWY-735;Reactome: R-HSA-9033241;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-7854;KEGG: 00592+1.3.3.6;MetaCyc: PWY-6837;MetaCyc: PWY-7337;MetaCyc: PWY-7291;KEGG: 00071+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-7288;MetaCyc: PWY-6920;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7858 "10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoyl-coa degradation II";"Methyl ketone biosynthesis (engineered)";"Jasmonic acid biosynthesis";"Peroxisomal protein import";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"6-gingerol analog biosynthesis (engineered)";"beta-Alanine metabolism";"(5Z)-dodecenoate biosynthesis II" lcl|NW_020311992.1_prot_XP_012266476.1_21269 4 MetaCyc: PWY-5912;MetaCyc: PWY-5041;Reactome: R-HSA-156581;KEGG: 00270+2.5.1.6 "2'-deoxymugineic acid phytosiderophore biosynthesis";"S-adenosyl-L-methionine cycle II";"Methylation";"Cysteine and methionine metabolism" lcl|NW_020311965.1_prot_XP_012260313.1_14168 4 KEGG: 00330+4.1.1.50;KEGG: 00270+4.1.1.50;Reactome: R-HSA-351202;MetaCyc: PWY-6834 "Arginine and proline metabolism";"Cysteine and methionine metabolism";"Metabolism of polyamines";"Spermidine biosynthesis III" lcl|NW_020311980.1_prot_XP_012261343.1_18814 2 Reactome: R-HSA-5357956;Reactome: R-HSA-5357905 "TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling" lcl|NW_020311995.1_prot_XP_012256360.1_22072 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311513.1_prot_XP_020711390.1_9890 6 KEGG: 00510+2.4.1.143;KEGG: 00513+2.4.1.143;Reactome: R-HSA-4793952;MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578 "N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway" lcl|NW_020311313.1_prot_XP_012261651.1_2844 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311978.1_prot_XP_025602789.1_18038 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" lcl|NW_020311962.1_prot_XP_012251962.1_13765 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311298.1_prot_XP_012250598.1_1169 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311499.1_prot_XP_012269249.1_9567 3 Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482 "Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events" lcl|NW_020311395.1_prot_XP_012260732.1_7228 7 Reactome: R-HSA-165054;Reactome: R-HSA-203927;Reactome: R-HSA-180746;Reactome: R-HSA-1655829;Reactome: R-HSA-168333;Reactome: R-HSA-5578749;Reactome: R-HSA-6784531 "Rev-mediated nuclear export of HIV RNA";"MicroRNA (miRNA) biogenesis";"Nuclear import of Rev protein";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transcriptional regulation by small RNAs";"tRNA processing in the nucleus" lcl|NW_020311966.1_prot_XP_012256392.1_14949 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311973.1_prot_XP_012258580.1_16340 1 Reactome: R-HSA-112126 "ALKBH3 mediated reversal of alkylation damage" lcl|NW_020311401.1_prot_XP_012255117.1_7447 11 Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-68952;Reactome: R-HSA-5696397;Reactome: R-HSA-68962;Reactome: R-HSA-5696400;Reactome: R-HSA-174430;Reactome: R-HSA-5685942;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801 "Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"DNA replication initiation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Activation of the pre-replicative complex";"Dual Incision in GG-NER";"Telomere C-strand synthesis initiation";"HDR through Homologous Recombination (HRR)";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair" lcl|NW_020311286.1_prot_XP_012256441.1_212 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311972.1_prot_XP_012264452.1_16289 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311977.1_prot_XP_020710550.1_17881 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311397.1_prot_XP_020707302.1_7343 3 Reactome: R-HSA-75109;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Triglyceride biosynthesis";"Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311293.1_prot_XP_012251391.1_762 1 Reactome: R-HSA-5685939 "HDR through MMEJ (alt-NHEJ)" lcl|NW_020311365.1_prot_XP_012269476.1_6036 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311380.1_prot_XP_012268179.1_6696 3 Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594 "Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events" lcl|NW_020311304.1_prot_XP_012260916.1_1769 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311961.1_prot_XP_012262686.1_13363 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311324.1_prot_XP_012269384.1_3512 10 MetaCyc: PWY-8053;MetaCyc: PWY-8055;KEGG: 00564+2.3.1.15;MetaCyc: PWY-7411;MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.15;Reactome: R-HSA-1483166;MetaCyc: PWY-5667;MetaCyc: PWY-7587 "Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Glycerophospholipid metabolism";"Phosphatidate biosynthesis (yeast)";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Synthesis of PA";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)" lcl|NW_020311975.1_prot_XP_012266214.1_17200 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311513.1_prot_XP_020711413.1_9689 1 Reactome: R-HSA-426486 "Small interfering RNA (siRNA) biogenesis" lcl|NW_020311955.1_prot_XP_012265371.1_12446 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311287.1_prot_XP_020711798.1_260 4 KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-6483;MetaCyc: PWY-7119 "Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)" lcl|NW_020311360.1_prot_XP_012251624.1_5740 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311295.1_prot_XP_012255615.1_922 7 MetaCyc: PWY-7158;KEGG: 00360+1.14.16.1;MetaCyc: PWY-6134;KEGG: 00400+1.14.16.1;Reactome: R-HSA-8964208;KEGG: 00790+1.14.16.1;Reactome: R-HSA-2160456 "L-phenylalanine degradation V";"Phenylalanine metabolism";"L-tyrosine biosynthesis IV";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Phenylalanine metabolism";"Folate biosynthesis";"Phenylketonuria" lcl|NW_020311436.1_prot_XP_025602101.1_8798 4 Reactome: R-HSA-212300;KEGG: 00270+2.1.1.37;Reactome: R-HSA-4655427;Reactome: R-HSA-5334118 "PRC2 methylates histones and DNA";"Cysteine and methionine metabolism";"SUMOylation of DNA methylation proteins";"DNA methylation" lcl|NW_020311327.1_prot_XP_012252899.1_3758 1 Reactome: R-HSA-6811438 "Intra-Golgi traffic" lcl|NW_020311994.1_prot_XP_012262180.1_21849 2 Reactome: R-HSA-1483166;Reactome: R-HSA-1483148 "Synthesis of PA";"Synthesis of PG" lcl|NW_020311321.1_prot_XP_012263204.1_3412 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311940.1_prot_XP_020711224.1_11198 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311312.1_prot_XP_012266863.1_2684 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311985.1_prot_XP_012265251.1_20211 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311973.1_prot_XP_020708841.1_16332 1 Reactome: R-HSA-912446 "Meiotic recombination" lcl|NW_020311299.1_prot_XP_025602566.1_1416 5 KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7921 "Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)" lcl|NW_020311353.1_prot_XP_012256075.1_5402 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311959.1_prot_XP_025602470.1_13189 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311971.1_prot_XP_012260796.1_15824 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311975.1_prot_XP_012252625.1_17098 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311360.1_prot_XP_012251646.1_5722 1 Reactome: R-HSA-9018519 "Estrogen-dependent gene expression" lcl|NW_020311982.1_prot_XP_020708766.1_19210 5 Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.10;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3 "Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311318.1_prot_XP_025603082.1_3266 4 Reactome: R-HSA-9031525;MetaCyc: PWY-7511;Reactome: R-HSA-8866427;Reactome: R-HSA-983168 "NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake";"Protein ubiquitination";"VLDLR internalisation and degradation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311315.1_prot_XP_020711104.1_3096 1 Reactome: R-HSA-8866654 "E3 ubiquitin ligases ubiquitinate target proteins" lcl|NW_020311436.1_prot_XP_012258385.1_8750 4 Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-77595 "mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs" lcl|NW_020311943.1_prot_XP_012255096.1_11742 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311315.1_prot_XP_012265155.1_3108 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311373.1_prot_XP_012251289.1_6510 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311968.1_prot_XP_012253071.1_15457 3 Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311966.1_prot_XP_012256447.1_14616 1 Reactome: R-HSA-4615885 "SUMOylation of DNA replication proteins" lcl|NW_020311372.1_prot_XP_012268409.1_6330 4 Reactome: R-HSA-72731;MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174 "Recycling of eIF2:GDP";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II" lcl|NW_020311361.1_prot_XP_020709847.1_5809 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311974.1_prot_XP_020709333.1_16713 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311943.1_prot_XP_012255344.1_11701 14 Reactome: R-HSA-380284;Reactome: R-HSA-9648025;Reactome: R-HSA-8854518;Reactome: R-HSA-68877;Reactome: R-HSA-5620912;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-380270;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-141444;Reactome: R-HSA-2565942;Reactome: R-HSA-5663220;Reactome: R-HSA-380259 "Loss of proteins required for interphase microtubule organization from the centrosome";"EML4 and NUDC in mitotic spindle formation";"AURKA Activation by TPX2";"Mitotic Prometaphase";"Anchoring of the basal body to the plasma membrane";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Recruitment of mitotic centrosome proteins and complexes";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Regulation of PLK1 Activity at G2/M Transition";"RHO GTPases Activate Formins";"Loss of Nlp from mitotic centrosomes" lcl|NW_020311290.1_prot_XP_020706880.1_438 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" lcl|NW_020311292.1_prot_XP_012252584.1_627 3 MetaCyc: PWY-7887;Reactome: R-HSA-6787450;MetaCyc: PWY-7892 "Protein SAMPylation and SAMP-mediated thiolation";"tRNA modification in the mitochondrion";"Trna-uridine 2-thiolation and selenation (bacteria)" lcl|NW_020311966.1_prot_XP_012256386.1_14962 7 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" lcl|NW_020311966.1_prot_XP_012251742.1_14572 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311918.1_prot_XP_012264204.1_10296 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311943.1_prot_XP_020707743.1_11547 3 Reactome: R-HSA-110329;Reactome: R-HSA-110328;Reactome: R-HSA-110357 "Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Displacement of DNA glycosylase by APEX1" lcl|NW_020311973.1_prot_XP_012258768.1_16398 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311311.1_prot_XP_020706399.1_2532 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311292.1_prot_XP_020706867.1_557 4 KEGG: 00030+1.1.1.49;MetaCyc: PWY-8004;MetaCyc: PWY-7268;KEGG: 00480+1.1.1.49 "Pentose phosphate pathway";"Entner-Doudoroff pathway I";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism" lcl|NW_020311353.1_prot_XP_012255918.1_5416 3 Reactome: R-HSA-1660661;KEGG: 00600+1.14.19.17;MetaCyc: PWY-5129 "Sphingolipid de novo biosynthesis";"Sphingolipid metabolism";"Sphingolipid biosynthesis (plants)" lcl|NW_020311970.1_prot_XP_025602643.1_15704 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311973.1_prot_XP_012258606.1_16596 1 Reactome: R-HSA-8964038 "LDL clearance" lcl|NW_020311965.1_prot_XP_012259840.1_14049 32 Reactome: R-HSA-167238;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-75955;Reactome: R-HSA-72086;Reactome: R-HSA-72165;Reactome: R-HSA-75953;Reactome: R-HSA-77075;Reactome: R-HSA-8851708;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-167161;Reactome: R-HSA-167242;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-76042;Reactome: R-HSA-113418;Reactome: R-HSA-72163;Reactome: R-HSA-112382;Reactome: R-HSA-167158 "Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Elongation";"mRNA Capping";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"HIV Transcription Initiation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of the Early Elongation Complex";"mRNA Splicing - Major Pathway";"Formation of RNA Pol II elongation complex";"Formation of the HIV-1 Early Elongation Complex" lcl|NW_020311978.1_prot_XP_012257707.1_18467 2 Reactome: R-HSA-3214847;Reactome: R-HSA-171319 "HATs acetylate histones";"Telomere Extension By Telomerase" lcl|NW_020311304.1_prot_XP_012261098.1_1912 10 Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-5607761;Reactome: R-HSA-5684264;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-2565942 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"FCERI mediated NF-kB activation";"Dectin-1 mediated noncanonical NF-kB signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Regulation of PLK1 Activity at G2/M Transition" lcl|NW_020311380.1_prot_XP_012268223.1_6755 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" lcl|NW_020311403.1_prot_XP_020708791.1_7730 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311934.1_prot_XP_012254848.1_10879 1 Reactome: R-HSA-1474151 "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" lcl|NW_020311946.1_prot_XP_012268652.1_11918 1 Reactome: R-HSA-197264 "Nicotinamide salvaging" lcl|NW_020311324.1_prot_XP_012269304.1_3548 11 Reactome: R-HSA-500753;KEGG: 00240+2.1.3.2;MetaCyc: PWY-5686;KEGG: 00240+6.3.5.5;KEGG: 00250+2.1.3.2;KEGG: 00250+6.3.5.5;MetaCyc: PWY-7400;MetaCyc: PWY-7790;KEGG: 00240+3.5.2.3;MetaCyc: PWY-7791;MetaCyc: PWY-5154 "Pyrimidine biosynthesis";"Pyrimidine metabolism";"UMP biosynthesis I";"Pyrimidine metabolism";"Alanine, aspartate and glutamate metabolism";"Alanine, aspartate and glutamate metabolism";"L-arginine biosynthesis IV (archaebacteria)";"UMP biosynthesis II";"Pyrimidine metabolism";"UMP biosynthesis III";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)" lcl|NW_020311983.1_prot_XP_012267173.1_19527 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311494.1_prot_XP_025602168.1_9491 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311343.1_prot_XP_020708749.1_4785 3 Reactome: R-HSA-983168;Reactome: R-HSA-6798695;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"Protein ubiquitination" lcl|NW_020311513.1_prot_XP_020711462.1_9870 4 Reactome: R-HSA-5358493;MetaCyc: PWY-7546;MetaCyc: PWY-6482;Reactome: R-HSA-8849175 "Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)";"Threonine catabolism" lcl|NW_020311309.1_prot_XP_020709042.1_2355 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" lcl|NW_020311325.1_prot_XP_020706321.1_3682 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" lcl|NW_020311298.1_prot_XP_012269876.1_1338 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" lcl|NW_020311992.1_prot_XP_012266310.1_21274 14 MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-8053;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482788;KEGG: 00592+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-975634 "Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Plasmalogen degradation";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Arachidonic acid metabolism";"Acyl chain remodelling of PC";"alpha-Linolenic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Retinoid metabolism and transport" lcl|NW_020311988.1_prot_XP_012261106.1_20736 14 MetaCyc: PWY-7619;MetaCyc: PWY-5972;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-5080;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7601;MetaCyc: PWY-7724;Reactome: R-HSA-75876 "Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs" lcl|NW_020311383.1_prot_XP_012251556.1_6885 12 Reactome: R-HSA-76066;Reactome: R-HSA-73980;Reactome: R-HSA-427413;Reactome: R-HSA-1834949;Reactome: R-HSA-5250924;Reactome: R-HSA-76071;Reactome: R-HSA-73762;Reactome: R-HSA-73780;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-73772;Reactome: R-HSA-73863 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination";"NoRC negatively regulates rRNA expression";"Cytosolic sensors of pathogen-associated DNA";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase I Transcription Initiation";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination" lcl|NW_020311346.1_prot_XP_020709639.1_5030 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311948.1_prot_XP_012253472.1_11997 3 Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311323.1_prot_XP_012268134.1_3488 4 KEGG: 00532+2.4.2.26;KEGG: 00534+2.4.2.26;Reactome: R-HSA-1971475;MetaCyc: PWY-6557 "Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"A tetrasaccharide linker sequence is required for GAG synthesis";"Glycosaminoglycan-protein linkage region biosynthesis" lcl|NW_020311994.1_prot_XP_012267362.1_21604 2 Reactome: R-HSA-9610379;Reactome: R-HSA-917729 "HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)" lcl|NW_020311978.1_prot_XP_012257919.1_18426 2 Reactome: R-HSA-6783984;KEGG: 00260+1.4.4.2 "Glycine degradation";"Glycine, serine and threonine metabolism" lcl|NW_020311292.1_prot_XP_012252410.1_564 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311964.1_prot_XP_012261967.1_13878 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311365.1_prot_XP_012259876.1_5944 16 MetaCyc: PWY-6142;MetaCyc: PWY-8004;Reactome: R-HSA-70263;MetaCyc: PWY-1042;MetaCyc: PWY-6886;Reactome: R-HSA-70171;MetaCyc: PWY-7124;MetaCyc: PWY-1622;KEGG: 00680+4.2.1.11;MetaCyc: PWY-7003;MetaCyc: PWY-6901;MetaCyc: PWY-2221;MetaCyc: PWY-5484;KEGG: 00010+4.2.1.11;MetaCyc: PWY-7218;MetaCyc: PWY-5723 "Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway I";"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis";"Ethylene biosynthesis V (engineered)";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Glycerol degradation to butanol";"Superpathway of glucose and xylose degradation";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Rubisco shunt" lcl|NW_020311994.1_prot_XP_020711894.1_21535 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311382.1_prot_XP_012268018.1_6860 1 Reactome: R-HSA-69273 "Cyclin A/B1/B2 associated events during G2/M transition" lcl|NW_020311298.1_prot_XP_012250572.1_1272 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311477.1_prot_XP_012262345.1_9446 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" lcl|NW_020311291.1_prot_XP_012259521.1_472 1 Reactome: R-HSA-1660499 "Synthesis of PIPs at the plasma membrane" lcl|NW_020311962.1_prot_XP_012252154.1_13735 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" lcl|NW_020311944.1_prot_XP_012254209.1_11777 2 Reactome: R-HSA-6807004;Reactome: R-HSA-877312 "Negative regulation of MET activity";"Regulation of IFNG signaling" lcl|NW_020311397.1_prot_XP_012258197.1_7299 3 Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" lcl|NW_020311294.1_prot_XP_012264956.1_913 4 MetaCyc: PWY-7204;Reactome: R-HSA-964975;KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282 "Pyridoxal 5'-phosphate salvage II (plants)";"Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis" lcl|NW_020311961.1_prot_XP_012262525.1_13264 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311388.1_prot_XP_020710954.1_6995 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311971.1_prot_XP_020710524.1_16074 12 Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Mitotic Prometaphase";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"HCMV Early Events";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" lcl|NW_020311430.1_prot_XP_020707123.1_8292 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311334.1_prot_XP_020711369.1_4373 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311966.1_prot_XP_025602591.1_14480 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" lcl|NW_020311432.1_prot_XP_012268675.1_8386 1 Reactome: R-HSA-373753 "Nephrin family interactions" lcl|NW_020311477.1_prot_XP_012262347.1_9449 4 Reactome: R-HSA-73614;MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48;KEGG: 00983+2.7.1.48 "Pyrimidine salvage";"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism";"Drug metabolism - other enzymes" lcl|NW_020311312.1_prot_XP_012266774.1_2727 4 Reactome: R-HSA-8856828;Reactome: R-HSA-5663213;Reactome: R-HSA-3928662;Reactome: R-HSA-2029482 "Clathrin-mediated endocytosis";"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation" lcl|NW_020311983.1_prot_XP_012255671.1_19698 29 Reactome: R-HSA-427413;Reactome: R-HSA-5696400;Reactome: R-HSA-6781823;Reactome: R-HSA-6796648;Reactome: R-HSA-73863;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-76042;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-72086;Reactome: R-HSA-6781827;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-73772;Reactome: R-HSA-5696395;Reactome: R-HSA-167152;Reactome: R-HSA-6782210 "NoRC negatively regulates rRNA expression";"Dual Incision in GG-NER";"Formation of TC-NER Pre-Incision Complex";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"mRNA Capping";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase I Promoter Escape";"Formation of Incision Complex in GG-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER" lcl|NW_020311401.1_prot_XP_020707807.1_7599 3 Reactome: R-HSA-422085;Reactome: R-HSA-112311;Reactome: R-HSA-1483191 "Synthesis, secretion, and deacylation of Ghrelin";"Neurotransmitter clearance";"Synthesis of PC" lcl|NW_020311292.1_prot_XP_012252562.1_568 4 Reactome: R-HSA-202040;Reactome: R-HSA-418594;Reactome: R-HSA-6814122;Reactome: R-HSA-112043 "G-protein activation";"G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"PLC beta mediated events" lcl|NW_020311992.1_prot_XP_012266294.1_21138 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" lcl|NW_020311978.1_prot_XP_020708566.1_18064 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311979.1_prot_XP_012261415.1_18666 3 Reactome: R-HSA-6783984;KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine degradation";"Glycine, serine and threonine metabolism";"One carbon pool by folate" lcl|NW_020311976.1_prot_XP_012253539.1_17267 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311934.1_prot_XP_012255274.1_10846 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" lcl|NW_020311958.1_prot_XP_020708041.1_12983 13 Reactome: R-HSA-381676;Reactome: R-HSA-139853;Reactome: R-HSA-5218921;Reactome: R-HSA-112043;Reactome: R-HSA-4086398;Reactome: R-HSA-983695;Reactome: R-HSA-422356;Reactome: R-HSA-1489509;Reactome: R-HSA-114508;Reactome: R-HSA-2871809;Reactome: R-HSA-5578775;Reactome: R-HSA-5607763;Reactome: R-HSA-2029485 "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Elevation of cytosolic Ca2+ levels";"VEGFR2 mediated cell proliferation";"PLC beta mediated events";"Ca2+ pathway";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Regulation of insulin secretion";"DAG and IP3 signaling";"Effects of PIP2 hydrolysis";"FCERI mediated Ca+2 mobilization";"Ion homeostasis";"CLEC7A (Dectin-1) induces NFAT activation";"Role of phospholipids in phagocytosis" lcl|NW_020311926.1_prot_XP_012250865.1_10615 56 Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-5610780;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5610785;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-1236978;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-5668541;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-349425;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050 "Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI1 by the proteasome";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of RAS by GAPs";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis" lcl|NW_020311311.1_prot_XP_012250754.1_2541 8 KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04151+2.7.11.1 "Thermogenesis";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Human papillomavirus infection";"Major pathway of rRNA processing in the nucleolus and cytosol";"PI3K-Akt signaling pathway" lcl|NW_020311958.1_prot_XP_012255836.1_12941 3 KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16 "Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer" lcl|NW_020311917.1_prot_XP_012251024.1_10210 1 Reactome: R-HSA-380320 "Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311983.1_prot_XP_012255653.1_19721 12 Reactome: R-HSA-6807878;Reactome: R-HSA-5620912;Reactome: R-HSA-381038;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-6811436 "COPI-mediated anterograde transport";"Anchoring of the basal body to the plasma membrane";"XBP1(S) activates chaperone genes";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311456.1_prot_XP_012255847.1_9116 10 MetaCyc: PWY-6535;Reactome: R-HSA-916853;MetaCyc: PWY-5022;KEGG: 00250+2.6.1.19;MetaCyc: PWY-6537;KEGG: 00640+2.6.1.19;KEGG: 00650+2.6.1.19;MetaCyc: PWY-6536;MetaCyc: PWY-4321;KEGG: 00410+2.6.1.19 "4-aminobutanoate degradation I";"Degradation of GABA";"4-aminobutanoate degradation V";"Alanine, aspartate and glutamate metabolism";"4-aminobutanoate degradation II";"Propanoate metabolism";"Butanoate metabolism";"4-aminobutanoate degradation III";"L-glutamate degradation IV";"beta-Alanine metabolism" lcl|NW_020311971.1_prot_XP_012263631.1_16117 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311981.1_prot_XP_012257368.1_19173 2 Reactome: R-HSA-1660662;Reactome: R-HSA-390471 "Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis" lcl|NW_020311994.1_prot_XP_020710955.1_21810 8 Reactome: R-HSA-6798695;Reactome: R-HSA-9627069;Reactome: R-HSA-111459;Reactome: R-HSA-6803207;Reactome: R-HSA-111464;Reactome: R-HSA-8953750;Reactome: R-HSA-111458;Reactome: R-HSA-111463 "Neutrophil degranulation";"Regulation of the apoptosome activity";"Activation of caspases through apoptosome-mediated cleavage";"TP53 Regulates Transcription of Caspase Activators and Caspases";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Transcriptional Regulation by E2F6";"Formation of apoptosome";"SMAC (DIABLO) binds to IAPs" lcl|NW_020311948.1_prot_XP_012253528.1_12018 2 KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10 "One carbon pool by folate";"Glycine, serine and threonine metabolism" lcl|NW_020311377.1_prot_XP_012260464.1_6596 5 MetaCyc: PWY-8060;Reactome: R-HSA-71336;Reactome: R-HSA-6798695;MetaCyc: PWY-7180;KEGG: 00030+4.1.2.4 "2-deoxy-D-ribose degradation I";"Pentose phosphate pathway";"Neutrophil degranulation";"2-deoxy-alpha-D-ribose 1-phosphate degradation";"Pentose phosphate pathway" lcl|NW_020311973.1_prot_XP_012258573.1_16344 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311347.1_prot_XP_020711465.1_5072 5 Reactome: R-HSA-1655829;Reactome: R-HSA-983170;Reactome: R-HSA-204005;Reactome: R-HSA-5694530;Reactome: R-HSA-2132295 "Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"COPII-mediated vesicle transport";"Cargo concentration in the ER";"MHC class II antigen presentation" lcl|NW_020311350.1_prot_XP_020706627.1_5346 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins" lcl|NW_020311549.1_prot_XP_025602213.1_10035 31 MetaCyc: PWY-4381;MetaCyc: PWY-5367;MetaCyc: PWYG-321;MetaCyc: PWY-5142;MetaCyc: PWY-6519;Reactome: R-HSA-2426168;MetaCyc: PWY-5147;MetaCyc: PWY-5973;Reactome: R-HSA-163765;Reactome: R-HSA-199220;Reactome: R-HSA-75105;MetaCyc: PWY-7664;MetaCyc: PWY-5966-1;MetaCyc: PWY-6282;MetaCyc: PWY-7723;MetaCyc: PWY-5366;MetaCyc: PWY-8049;MetaCyc: PWY-7388;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-9029558;MetaCyc: PWY-8012;MetaCyc: PWY-5971;MetaCyc: PWY-5994;MetaCyc: PWY-6799;MetaCyc: PWY-5989;MetaCyc: PWY-8047;MetaCyc: PWY-7746;MetaCyc: PWY-6113;MetaCyc: PWY-7858;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-7663 "Fatty acid biosynthesis initiation (bacteria and plants)";"Petroselinate biosynthesis";"";"Acyl-[acyl-carrier protein] thioesterase pathway";"8-amino-7-oxononanoate biosynthesis I";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis I (plants)";"Cis-vaccenate biosynthesis";"ChREBP activates metabolic gene expression";"Vitamin B5 (pantothenate) metabolism";"Fatty acyl-CoA biosynthesis";"Oleate biosynthesis IV (anaerobic)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Bacterial bioluminescence";"Palmitoleate biosynthesis II (plants and bacteria)";"Pederin biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Biotin metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Mupirocin biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Stearate biosynthesis II (bacteria and plants)";"Bryostatin biosynthesis";"Mycobacterial sulfolipid biosynthesis";"Superpathway of mycolate biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Fatty acid biosynthesis";"Gondoate biosynthesis (anaerobic)" lcl|NW_020311993.1_prot_XP_020709833.1_21300 2 Reactome: R-HSA-917729;Reactome: R-HSA-9610379 "Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events" lcl|NW_020311977.1_prot_XP_012252245.1_17468 5 Reactome: R-HSA-8964539;MetaCyc: PWY-6344;MetaCyc: PWY-3341;KEGG: 00330+1.5.1.2;MetaCyc: PWY-4981 "Glutamate and glutamine metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism";"L-proline biosynthesis II (from arginine)" lcl|NW_020311994.1_prot_XP_012267382.1_21763 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311300.1_prot_XP_012253163.1_1526 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311958.1_prot_XP_020708072.1_12994 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311985.1_prot_XP_012265213.1_20260 6 MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782 "Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311973.1_prot_XP_012258622.1_16480 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" lcl|NW_020311353.1_prot_XP_012256047.1_5447 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" lcl|NW_020311312.1_prot_XP_012266760.1_2685 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311308.1_prot_XP_012264455.1_2200 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311477.1_prot_XP_012262234.1_9424 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311373.1_prot_XP_012266676.1_6433 13 KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-3928662;Reactome: R-HSA-4420097;Reactome: R-HSA-416572;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5627117;Reactome: R-HSA-3928663;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"EPHB-mediated forward signaling";"VEGFA-VEGFR2 Pathway";"Sema4D induced cell migration and growth-cone collapse";"Thermogenesis";"G alpha (12/13) signalling events";"Relaxin signaling pathway";"mTOR signaling pathway";"RHO GTPases Activate ROCKs";"EPHA-mediated growth cone collapse";"Human immunodeficiency virus 1 infection" lcl|NW_020311289.1_prot_XP_020708093.1_411 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311393.1_prot_XP_012265749.1_7154 7 KEGG: 00230+3.5.2.5;MetaCyc: PWY-5698;MetaCyc: PWY-5697;KEGG: 00240+3.5.2.3;MetaCyc: PWY-7791;MetaCyc: PWY-5686;MetaCyc: PWY-7790 "Purine metabolism";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Allantoin degradation to ureidoglycolate I (urea producing)";"Pyrimidine metabolism";"UMP biosynthesis III";"UMP biosynthesis I";"UMP biosynthesis II" lcl|NW_020311943.1_prot_XP_012255330.1_11693 12 MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7409 "Plasmalogen degradation";"Linoleic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)" lcl|NW_020311970.1_prot_XP_012256765.1_15708 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311971.1_prot_XP_020710523.1_16072 3 Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148 "Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311974.1_prot_XP_012260009.1_16655 6 Reactome: R-HSA-210500;Reactome: R-HSA-181429;Reactome: R-HSA-181430;Reactome: R-HSA-388844;Reactome: R-HSA-264642;Reactome: R-HSA-212676 "Glutamate Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle" lcl|NW_020311973.1_prot_XP_020708900.1_16602 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" lcl|NW_020311292.1_prot_XP_012252505.1_578 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311955.1_prot_XP_012265368.1_12428 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311317.1_prot_XP_012250753.1_3241 13 Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689 "Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits" lcl|NW_020311978.1_prot_XP_025602778.1_18048 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311995.1_prot_XP_012257085.1_22104 5 Reactome: R-HSA-8854214;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-165181 "TBC/RABGAPs";"Macroautophagy";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Inhibition of TSC complex formation by PKB" lcl|NW_020311296.1_prot_XP_012264857.1_994 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311310.1_prot_XP_012255822.1_2408 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311971.1_prot_XP_012263535.1_16083 12 Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-68877 "Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"HCMV Early Events";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Mitotic Prometaphase" lcl|NW_020311393.1_prot_XP_012265753.1_7157 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311907.1_prot_XP_020710987.1_10145 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311967.1_prot_XP_025602609.1_15254 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311940.1_prot_XP_012265574.1_11212 7 KEGG: 00500+2.4.1.25;MetaCyc: PWY-6737;MetaCyc: PWY-5941;Reactome: R-HSA-70221;Reactome: R-HSA-6798695;MetaCyc: PWY-6724;MetaCyc: PWY-7238 "Starch and sucrose metabolism";"Starch degradation V";"Glycogen degradation II";"Glycogen breakdown (glycogenolysis)";"Neutrophil degranulation";"Starch degradation II";"Sucrose biosynthesis II" lcl|NW_020311994.1_prot_XP_025603014.1_21538 2 Reactome: R-HSA-877300;Reactome: R-HSA-2132295 "Interferon gamma signaling";"MHC class II antigen presentation" lcl|NW_020311415.1_prot_XP_020712444.1_7931 2 Reactome: R-HSA-389661;Reactome: R-HSA-9033241 "Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import" lcl|NW_020311313.1_prot_XP_012261814.1_2814 22 MetaCyc: PWY-7049;MetaCyc: PWY-5080;MetaCyc: PWY-7619;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7728;Reactome: R-HSA-75876;MetaCyc: PWY-7727;MetaCyc: PWY-7724;MetaCyc: PWY-7726;MetaCyc: PWY-7725;MetaCyc: PWY-6598;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6958;MetaCyc: PWY-5353;MetaCyc: PWY-7601;MetaCyc: PWY-7053;MetaCyc: PWY-7606;MetaCyc: PWY-7592;MetaCyc: PWY-7035 "Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Juniperonate biosynthesis";"Fatty acid elongation";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Synthesis of very long-chain fatty acyl-CoAs";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"(9Z)-tricosene biosynthesis" lcl|NW_020311475.1_prot_XP_012253324.1_9386 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311445.1_prot_XP_012266735.1_8922 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311327.1_prot_XP_012252823.2_3774 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311353.1_prot_XP_012255967.1_5464 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311375.1_prot_XP_012256604.1_6538 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection" lcl|NW_020311971.1_prot_XP_025602671.1_15840 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311286.1_prot_XP_020708273.1_158 7 MetaCyc: PWY-31;Reactome: R-HSA-70635;MetaCyc: PWY-6922;KEGG: 00220+3.5.3.1;KEGG: 00330+3.5.3.1;MetaCyc: PWY-46;MetaCyc: PWY-4984 "Canavanine degradation";"Urea cycle";"L-Ndelta-acetylornithine biosynthesis";"Arginine biosynthesis";"Arginine and proline metabolism";"Putrescine biosynthesis III";"Urea cycle" lcl|NW_020311978.1_prot_XP_012257956.1_18369 7 MetaCyc: PWY-6470;Reactome: R-HSA-5633231;MetaCyc: PWY-6385;MetaCyc: PWY-5265;KEGG: 00550+2.4.1.227;Reactome: R-HSA-446193;MetaCyc: PWY-6471 "Peptidoglycan biosynthesis V (beta-lactam resistance)";"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Peptidoglycan biosynthesis III (mycobacteria)";"Peptidoglycan biosynthesis II (staphylococci)";"Peptidoglycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis IV (Enterococcus faecium)" lcl|NW_020311995.1_prot_XP_025603031.1_22074 14 Reactome: R-HSA-167152;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167238;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-113418 "Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex" lcl|NW_020311469.1_prot_XP_012266617.1_9297 1 Reactome: R-HSA-2028269 "Signaling by Hippo" lcl|NW_020311361.1_prot_XP_012261548.1_5801 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311943.1_prot_XP_012255331.1_11694 18 MetaCyc: PWY-6803;MetaCyc: PWY-7417;Reactome: R-HSA-1483166;Reactome: R-HSA-1482922;KEGG: 00591+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482801;MetaCyc: PWY-8051;Reactome: R-HSA-1482839;Reactome: R-HSA-1482925;MetaCyc: PWY-7783;MetaCyc: PWY-7409;MetaCyc: PWY-8053;Reactome: R-HSA-1482788 "Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidate, yeast)";"Synthesis of PA";"Acyl chain remodelling of PI";"Linoleic acid metabolism";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Acyl chain remodelling of PS";"Anandamide biosynthesis I";"Acyl chain remodelling of PE";"Acyl chain remodelling of PG";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PC" lcl|NW_020311967.1_prot_XP_012254339.1_15342 1 Reactome: R-HSA-70350 "Fructose catabolism" lcl|NW_020311499.1_prot_XP_012269240.1_9528 18 KEGG: 00401+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00250+2.6.1.1;MetaCyc: PWY-6638;KEGG: 00270+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00960+2.6.1.1;MetaCyc: PWY-5913;MetaCyc: PWY-6643;KEGG: 00330+2.6.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-7117;MetaCyc: PWY-7383;KEGG: 00360+2.6.1.1;MetaCyc: PWY-6642;KEGG: 00710+2.6.1.1;KEGG: 00400+2.6.1.1 "Novobiocin biosynthesis";"Isoquinoline alkaloid biosynthesis";"Tyrosine metabolism";"Alanine, aspartate and glutamate metabolism";"Sulfolactate degradation III";"Cysteine and methionine metabolism";"Arginine biosynthesis";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Coenzyme M biosynthesis II";"Arginine and proline metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Phenylalanine metabolism";"(R)-cysteate degradation";"Carbon fixation in photosynthetic organisms";"Phenylalanine, tyrosine and tryptophan biosynthesis" lcl|NW_020311995.1_prot_XP_012256268.1_21896 3 MetaCyc: PWY-6700;Reactome: R-HSA-6782315;MetaCyc: PWY-8106 "Queuosine biosynthesis I (de novo)";"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis III (queuosine salvage)" lcl|NW_020311334.1_prot_XP_012265860.1_4390 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311417.1_prot_XP_012259090.1_7950 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311302.1_prot_XP_020710868.1_1674 3 Reactome: R-HSA-196783;MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33 "Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis" lcl|NW_020311502.1_prot_XP_012251086.1_9598 15 MetaCyc: PWY-7003;MetaCyc: PWY-6142;MetaCyc: PWY-8004;MetaCyc: PWY-6901;MetaCyc: PWY-1042;MetaCyc: PWY-7383;MetaCyc: PWY-2221;MetaCyc: PWY-5484;KEGG: 00010+2.7.1.40;MetaCyc: PWY-6886;KEGG: 00230+2.7.1.40;Reactome: R-HSA-70171;MetaCyc: PWY-7218;MetaCyc: PWY-5723;KEGG: 00620+2.7.1.40 "Glycerol degradation to butanol";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway I";"Superpathway of glucose and xylose degradation";"Glycolysis IV (plant cytosol)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"1-butanol autotrophic biosynthesis (engineered)";"Purine metabolism";"Glycolysis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Rubisco shunt";"Pyruvate metabolism" lcl|NW_020311370.1_prot_XP_020710070.1_6268 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311981.1_prot_XP_012257360.1_19172 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311946.1_prot_XP_012268746.1_11897 8 KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00052+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00520+2.7.1.1 "Starch and sucrose metabolism";"Streptomycin biosynthesis";"Glycolysis";"Galactose metabolism";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Neomycin, kanamycin and gentamicin biosynthesis";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311325.1_prot_XP_012253363.1_3689 4 Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00983+2.7.1.48 "Pyrimidine salvage";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I";"Drug metabolism - other enzymes" lcl|NW_020311993.1_prot_XP_012262126.1_21422 15 Reactome: R-HSA-113418;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-6807505;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-167158;Reactome: R-HSA-167152;Reactome: R-HSA-167242 "Formation of the Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"RNA polymerase II transcribes snRNA genes";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat" lcl|NW_020311330.1_prot_XP_012267959.1_4046 4 Reactome: R-HSA-189483;Reactome: R-HSA-917937;MetaCyc: PWY-5874;KEGG: 00860+1.14.14.18 "Heme degradation";"Iron uptake and transport";"Heme degradation I";"Porphyrin and chlorophyll metabolism" lcl|NW_020311970.1_prot_XP_012269093.1_15616 4 Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394 "Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER" lcl|NW_020311985.1_prot_XP_012265217.1_20258 6 MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782 "Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311976.1_prot_XP_012253543.1_17273 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311993.1_prot_XP_012268371.1_21479 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311528.1_prot_XP_025602202.1_9968 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311356.1_prot_XP_020711755.1_5555 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" lcl|NW_020311971.1_prot_XP_020709599.1_15963 2 Reactome: R-HSA-430039;MetaCyc: PWY-6938 "mRNA decay by 5' to 3' exoribonuclease";"NADH repair" lcl|NW_020311332.1_prot_XP_012256840.1_4196 5 Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes" lcl|NW_020311971.1_prot_XP_012260853.1_15972 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311984.1_prot_XP_012254610.1_19892 13 Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557 "Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis" lcl|NW_020311918.1_prot_XP_012265019.1_10369 3 Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311992.1_prot_XP_012260882.1_20957 1 Reactome: R-HSA-3295583 "TRP channels" lcl|NW_020311386.1_prot_XP_012268136.1_6923 7 Reactome: R-HSA-6798695;KEGG: 00230+2.4.2.7;Reactome: R-HSA-74217;MetaCyc: PWY-6610;MetaCyc: PWY-6605;MetaCyc: PWY-7805;MetaCyc: PWY-7807 "Neutrophil degranulation";"Purine metabolism";"Purine salvage";"Adenine salvage";"Adenine and adenosine salvage II";"(aminomethyl)phosphonate degradation";"Glyphosate degradation III" lcl|NW_020311966.1_prot_XP_012256529.1_15016 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311312.1_prot_XP_012266831.1_2699 19 MetaCyc: PWY-6969;KEGG: 00630+1.1.1.37;KEGG: 00680+1.1.1.37;KEGG: 00720+1.1.1.37;KEGG: 00710+1.1.1.37;MetaCyc: PWY-561;MetaCyc: PWY-5392;MetaCyc: PWY-5690;MetaCyc: PWY-6728;KEGG: 00020+1.1.1.37;MetaCyc: PWY-5913;MetaCyc: PWY-1622;KEGG: 00270+1.1.1.37;MetaCyc: PWY-7115;MetaCyc: PWY-7383;KEGG: 00620+1.1.1.37;Reactome: R-HSA-70263;Reactome: R-HSA-71403;MetaCyc: PWY-8086 "TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Glyoxylate and dicarboxylate metabolism";"Methane metabolism";"Carbon fixation pathways in prokaryotes";"Carbon fixation in photosynthetic organisms";"Superpathway of glyoxylate cycle and fatty acid degradation";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Formaldehyde assimilation I (serine pathway)";"Cysteine and methionine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Pyruvate metabolism";"Gluconeogenesis";"Citric acid cycle (TCA cycle)";"(S)-lactate fermentation to propanoate, acetate and hydrogen" lcl|NW_020311441.1_prot_XP_012251240.1_8882 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311298.1_prot_XP_020706313.1_1128 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311962.1_prot_XP_012252119.1_13633 1 KEGG: 00860+4.4.1.17 "Porphyrin and chlorophyll metabolism" lcl|NW_020311333.1_prot_XP_012256009.1_4275 10 Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568;Reactome: R-HSA-912446;Reactome: R-HSA-69473;Reactome: R-HSA-5693579 "Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic recombination";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange" lcl|NW_020311298.1_prot_XP_012250594.1_1165 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311976.1_prot_XP_012257958.1_17370 6 Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72649 "Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation" lcl|NW_020311338.1_prot_XP_012263066.1_4532 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" lcl|NW_020311988.1_prot_XP_012260754.1_20563 5 KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2;MetaCyc: PWY-5084 "Citrate cycle (TCA cycle)";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA" lcl|NW_020311925.1_prot_XP_012252599.1_10535 4 Reactome: R-HSA-382556;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-5358346 "ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Hedgehog ligand biogenesis" lcl|NW_020311887.1_prot_XP_012267021.1_10128 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311959.1_prot_XP_020710136.1_13101 1 Reactome: R-HSA-196108 "Pregnenolone biosynthesis" lcl|NW_020311326.1_prot_XP_012261559.1_3701 2 Reactome: R-HSA-975577;Reactome: R-HSA-2022854 "N-Glycan antennae elongation";"Keratan sulfate biosynthesis" lcl|NW_020311338.1_prot_XP_012263027.1_4563 5 Reactome: R-HSA-6798695;Reactome: R-HSA-164843;Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;Reactome: R-HSA-3270619 "Neutrophil degranulation";"2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"IRF3-mediated induction of type I IFN" lcl|NW_020311995.1_prot_XP_012257267.1_21999 13 Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72689 "Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits" lcl|NW_020311978.1_prot_XP_020708600.1_18381 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins" lcl|NW_020311353.1_prot_XP_012256054.1_5412 3 KEGG: 00500+2.4.1.11;Reactome: R-HSA-3322077;MetaCyc: PWY-5067 "Starch and sucrose metabolism";"Glycogen synthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)" lcl|NW_020311354.1_prot_XP_012260724.1_5477 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311986.1_prot_XP_012258852.1_20331 8 Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-69166;Reactome: R-HSA-69183;Reactome: R-HSA-113501;Reactome: R-HSA-174411;Reactome: R-HSA-174430;Reactome: R-HSA-68962 "Polymerase switching";"DNA replication initiation";"Removal of the Flap Intermediate";"Processive synthesis on the lagging strand";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand synthesis initiation";"Activation of the pre-replicative complex" lcl|NW_020311426.1_prot_XP_012268514.1_8258 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" lcl|NW_020311967.1_prot_XP_020707527.1_15343 1 Reactome: R-HSA-70350 "Fructose catabolism" lcl|NW_020311313.1_prot_XP_012262023.1_3012 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311940.1_prot_XP_020711225.1_11199 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311976.1_prot_XP_012253548.1_17270 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311417.1_prot_XP_012259102.1_7951 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311977.1_prot_XP_020710717.1_17644 1 Reactome: R-HSA-427652 "Sodium-coupled phosphate cotransporters" lcl|NW_020311356.1_prot_XP_020711751.1_5574 1 Reactome: R-HSA-163560 "Triglyceride catabolism" lcl|NW_020311955.1_prot_XP_020711181.1_12512 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311433.1_prot_XP_020710686.1_8650 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" lcl|NW_020311292.1_prot_XP_020706869.1_559 4 KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268;MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49 "Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Entner-Doudoroff pathway I";"Pentose phosphate pathway" lcl|NW_020311343.1_prot_XP_020708748.1_4789 3 Reactome: R-HSA-983168;Reactome: R-HSA-6798695;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"Protein ubiquitination" lcl|NW_020311349.1_prot_XP_012251168.1_5227 7 KEGG: 00220+3.5.1.2;Reactome: R-HSA-8964539;MetaCyc: PWY-5921;Reactome: R-HSA-210500;KEGG: 00250+3.5.1.2;KEGG: 00471+3.5.1.2;Reactome: R-HSA-5628897 "Arginine biosynthesis";"Glutamate and glutamine metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate Neurotransmitter Release Cycle";"Alanine, aspartate and glutamate metabolism";"D-Glutamine and D-glutamate metabolism";"TP53 Regulates Metabolic Genes" lcl|NW_020311292.1_prot_XP_020710261.1_684 4 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-419037 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"NCAM1 interactions" lcl|NW_020311975.1_prot_XP_012254396.1_17006 14 MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-7417;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5667;MetaCyc: PWY-7587 "Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PA";"Plasmalogen biosynthesis";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)" lcl|NW_020311619.1_prot_XP_012260749.1_10078 2 Reactome: R-HSA-2029482;Reactome: R-HSA-5663213 "Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs" lcl|NW_020311959.1_prot_XP_012260439.1_13044 2 Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24 "Lysosomal oligosaccharide catabolism";"Other glycan degradation" lcl|NW_020311458.1_prot_XP_012264672.1_9160 5 Reactome: R-HSA-1660662;Reactome: R-HSA-2132295;Reactome: R-HSA-6798695;Reactome: R-HSA-4341670;Reactome: R-HSA-4085001 "Glycosphingolipid metabolism";"MHC class II antigen presentation";"Neutrophil degranulation";"Defective NEU1 causes sialidosis";"Sialic acid metabolism" lcl|NW_020311985.1_prot_XP_012265219.1_20224 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311499.1_prot_XP_012269241.1_9529 18 MetaCyc: PWY-6642;KEGG: 00710+2.6.1.1;KEGG: 00400+2.6.1.1;MetaCyc: PWY-7383;KEGG: 00360+2.6.1.1;KEGG: 00330+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-7115;MetaCyc: PWY-7117;MetaCyc: PWY-5913;KEGG: 00960+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00270+2.6.1.1;MetaCyc: PWY-6638;KEGG: 00250+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00401+2.6.1.1 "(R)-cysteate degradation";"Carbon fixation in photosynthetic organisms";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Phenylalanine metabolism";"Arginine and proline metabolism";"Coenzyme M biosynthesis II";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Partial TCA cycle (obligate autotrophs)";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Arginine biosynthesis";"Cysteine and methionine metabolism";"Sulfolactate degradation III";"Alanine, aspartate and glutamate metabolism";"Tyrosine metabolism";"Isoquinoline alkaloid biosynthesis";"Novobiocin biosynthesis" lcl|NW_020311312.1_prot_XP_012266908.1_2752 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" lcl|NW_020311995.1_prot_XP_012256785.1_21908 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311995.1_prot_XP_012256759.1_21979 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311956.1_prot_XP_025602425.1_12585 2 Reactome: R-HSA-72702;Reactome: R-HSA-72706 "Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311372.1_prot_XP_025601909.1_6324 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" lcl|NW_020311966.1_prot_XP_020708235.1_14753 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311309.1_prot_XP_020709072.1_2397 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311992.1_prot_XP_020711593.1_21013 13 Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72689 "Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits" lcl|NW_020311937.1_prot_XP_012252645.1_11032 6 Reactome: R-HSA-6814122;Reactome: R-HSA-389960;Reactome: R-HSA-5620922;Reactome: R-HSA-390471;Reactome: R-HSA-390450;Reactome: R-HSA-389957 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Formation of tubulin folding intermediates by CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Association of TriC/CCT with target proteins during biosynthesis";"Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC" lcl|NW_020311420.1_prot_XP_012260619.2_8122 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311961.1_prot_XP_012262523.1_13324 1 KEGG: 00970+6.1.1.20 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311971.1_prot_XP_020710491.1_16029 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311983.1_prot_XP_012255598.1_19661 6 Reactome: R-HSA-6798695;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210 "Neutrophil degranulation";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER" lcl|NW_020311343.1_prot_XP_020708746.1_4788 3 Reactome: R-HSA-983168;Reactome: R-HSA-6798695;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"Protein ubiquitination" lcl|NW_020311993.1_prot_XP_012262960.1_21330 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311362.1_prot_XP_020710995.1_5872 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311983.1_prot_XP_020711781.1_19449 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311992.1_prot_XP_012266471.1_21292 1 Reactome: R-HSA-70895 "Branched-chain amino acid catabolism" lcl|NW_020311401.1_prot_XP_012254960.1_7615 3 KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029;MetaCyc: PWY-7221 "Purine metabolism";"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311978.1_prot_XP_020708589.1_18357 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311396.1_prot_XP_012269614.1_7257 3 Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-8876198 "Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311934.1_prot_XP_012255035.1_10862 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311988.1_prot_XP_012255980.1_20518 6 Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-450513 "ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" lcl|NW_020311334.1_prot_XP_020711374.1_4372 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311393.1_prot_XP_012265720.1_7114 3 Reactome: R-HSA-1660516;Reactome: R-HSA-1660517;Reactome: R-HSA-1660514 "Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the late endosome membrane";"Synthesis of PIPs at the Golgi membrane" lcl|NW_020311982.1_prot_NP_001295471.1_19393 19 Reactome: R-HSA-8964026;Reactome: R-HSA-8963888;Reactome: R-HSA-8856828;Reactome: R-HSA-8866423;Reactome: R-HSA-8856825;Reactome: R-HSA-8957275;Reactome: R-HSA-3000480;Reactome: R-HSA-8964046;Reactome: R-HSA-8964041;Reactome: R-HSA-202733;Reactome: R-HSA-8964038;Reactome: R-HSA-8963901;Reactome: R-HSA-975634;Reactome: R-HSA-432142;Reactome: R-HSA-3000471;Reactome: R-HSA-381426;Reactome: R-HSA-5686938;Reactome: R-HSA-3000484;Reactome: R-HSA-3000497 "Chylomicron clearance";"Chylomicron assembly";"Clathrin-mediated endocytosis";"VLDL assembly";"Cargo recognition for clathrin-mediated endocytosis";"Post-translational protein phosphorylation";"Scavenging by Class A Receptors";"VLDL clearance";"LDL remodeling";"Cell surface interactions at the vascular wall";"LDL clearance";"Chylomicron remodeling";"Retinoid metabolism and transport";"Platelet sensitization by LDL";"Scavenging by Class B Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Regulation of TLR by endogenous ligand";"Scavenging by Class F Receptors";"Scavenging by Class H Receptors" lcl|NW_020311977.1_prot_XP_012263700.1_17875 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311308.1_prot_XP_020710839.1_2182 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311361.1_prot_XP_020709846.1_5805 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311940.1_prot_XP_012265571.1_11202 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311380.1_prot_XP_012268184.1_6768 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311992.1_prot_XP_020711551.1_21143 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311966.1_prot_XP_012252976.1_14538 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311397.1_prot_XP_012258202.1_7284 3 Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311982.1_prot_XP_020708764.1_19211 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311992.1_prot_XP_012266362.1_21147 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311946.1_prot_XP_020712294.1_11944 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311381.1_prot_XP_020706798.1_6835 2 Reactome: R-HSA-5689880;Reactome: R-HSA-5689603 "Ub-specific processing proteases";"UCH proteinases" lcl|NW_020311361.1_prot_XP_012261511.1_5792 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311966.1_prot_XP_012256504.1_14765 6 Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817 "Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)" lcl|NW_020311956.1_prot_XP_012254593.1_12578 4 Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-5625970;Reactome: R-HSA-983189 "MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate KTN1";"Kinesins" lcl|NW_020311967.1_prot_XP_025602601.1_15252 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311298.1_prot_XP_012250529.1_1358 2 Reactome: R-HSA-6798695;Reactome: R-HSA-9020702 "Neutrophil degranulation";"Interleukin-1 signaling" lcl|NW_020311312.1_prot_XP_020711714.1_2683 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311946.1_prot_XP_020712313.1_11901 1 Reactome: R-HSA-5689901 "Metalloprotease DUBs" lcl|NW_020311436.1_prot_XP_012258214.1_8776 3 Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596 "Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I" lcl|NW_020311426.1_prot_XP_012268522.1_8261 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311325.1_prot_XP_012266775.1_3652 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" lcl|NW_020311360.1_prot_XP_012251618.1_5719 4 Reactome: R-HSA-1483191;KEGG: 00564+3.1.1.7;Reactome: R-HSA-112311;Reactome: R-HSA-422085 "Synthesis of PC";"Glycerophospholipid metabolism";"Neurotransmitter clearance";"Synthesis, secretion, and deacylation of Ghrelin" lcl|NW_020311964.1_prot_XP_012261650.1_13961 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311401.1_prot_XP_012255067.1_7635 16 Reactome: R-HSA-9029569;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-8853884;Reactome: R-HSA-2559585;Reactome: R-HSA-8936459;Reactome: R-HSA-8934593;Reactome: R-HSA-8943723 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Transcriptional Regulation by VENTX";"Oncogene Induced Senescence";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX1 Expression and Activity";"Regulation of PTEN mRNA translation" lcl|NW_020311413.1_prot_XP_012254394.1_7902 1 Reactome: R-HSA-5624958 "ARL13B-mediated ciliary trafficking of INPP5E" lcl|NW_020311418.1_prot_XP_012261050.1_8020 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311329.1_prot_XP_025601730.1_3972 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311388.1_prot_XP_012264836.1_6957 2 Reactome: R-HSA-376176;Reactome: R-HSA-202433 "Signaling by ROBO receptors";"Generation of second messenger molecules" lcl|NW_020311293.1_prot_XP_012251396.1_780 6 Reactome: R-HSA-72163;Reactome: R-HSA-6782135;MetaCyc: PWY-7511;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823 "mRNA Splicing - Major Pathway";"Dual incision in TC-NER";"Protein ubiquitination";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex" lcl|NW_020311373.1_prot_XP_025601917.1_6398 6 Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450513 "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" lcl|NW_020311993.1_prot_XP_012265161.1_21494 2 KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20 "Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism" lcl|NW_020311983.1_prot_XP_012268353.1_19633 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311980.1_prot_XP_020709786.1_18864 1 Reactome: R-HSA-73621 "Pyrimidine catabolism" lcl|NW_020311294.1_prot_XP_020711021.1_869 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311966.1_prot_XP_012256870.1_14849 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311948.1_prot_XP_012253634.1_11992 12 KEGG: 00710+4.1.2.13;Reactome: R-HSA-70263;MetaCyc: PWY-1042;KEGG: 00680+4.1.2.13;MetaCyc: PWY-6142;KEGG: 00010+4.1.2.13;MetaCyc: PWY-7385;MetaCyc: PWY-1861;Reactome: R-HSA-70171;KEGG: 00030+4.1.2.13;KEGG: 00051+4.1.2.13;MetaCyc: PWY-5484 "Carbon fixation in photosynthetic organisms";"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Methane metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis / Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis";"Pentose phosphate pathway";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)" lcl|NW_020311349.1_prot_XP_012251140.1_5283 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311329.1_prot_XP_025601732.1_3970 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311298.1_prot_XP_012269932.1_1257 56 Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-1236978;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-174084;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-5668541;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-8951664;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9010553;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610785;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684 "G2/M Checkpoints";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"Cross-presentation of soluble exogenous antigens (endosomes)";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Autodegradation of Cdh1 by Cdh1:APC/C";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"TNFR2 non-canonical NF-kB pathway";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Neddylation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Regulation of expression of SLITs and ROBOs";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"GLI3 is processed to GLI3R by the proteasome";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state" lcl|NW_020311991.1_prot_XP_012269804.1_20945 6 Reactome: R-HSA-5651801;Reactome: R-HSA-5685939;Reactome: R-HSA-110362;Reactome: R-HSA-69166;Reactome: R-HSA-174437;Reactome: R-HSA-162594 "PCNA-Dependent Long Patch Base Excision Repair";"HDR through MMEJ (alt-NHEJ)";"POLB-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"Removal of the Flap Intermediate from the C-strand";"Early Phase of HIV Life Cycle" lcl|NW_020311292.1_prot_XP_020710259.1_681 4 Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-419037 "Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"NCAM1 interactions" lcl|NW_020311995.1_prot_XP_012257175.1_21890 9 Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73779;Reactome: R-HSA-76042 "RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance" lcl|NW_020311987.1_prot_XP_012266103.1_20358 7 Reactome: R-HSA-6798695;Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-264870;Reactome: R-HSA-373753 "Neutrophil degranulation";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Caspase-mediated cleavage of cytoskeletal proteins";"Nephrin family interactions" lcl|NW_020311976.1_prot_XP_012253620.1_17276 18 MetaCyc: PWY-8086;KEGG: 00620+1.1.1.37;Reactome: R-HSA-70263;MetaCyc: PWY-7383;MetaCyc: PWY-7115;KEGG: 00270+1.1.1.37;MetaCyc: PWY-5913;MetaCyc: PWY-1622;KEGG: 00020+1.1.1.37;MetaCyc: PWY-5392;MetaCyc: PWY-6728;MetaCyc: PWY-5690;KEGG: 00710+1.1.1.37;KEGG: 00720+1.1.1.37;MetaCyc: PWY-561;KEGG: 00680+1.1.1.37;KEGG: 00630+1.1.1.37;MetaCyc: PWY-6969 "(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Cysteine and methionine metabolism";"Partial TCA cycle (obligate autotrophs)";"Formaldehyde assimilation I (serine pathway)";"Citrate cycle (TCA cycle)";"Reductive TCA cycle II";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Carbon fixation in photosynthetic organisms";"Carbon fixation pathways in prokaryotes";"Superpathway of glyoxylate cycle and fatty acid degradation";"Methane metabolism";"Glyoxylate and dicarboxylate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)" lcl|NW_020311973.1_prot_XP_012258750.1_16496 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" lcl|NW_020311983.1_prot_XP_012255627.1_19806 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311995.1_prot_XP_012256756.1_21977 3 KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1;Reactome: R-HSA-73843 "Purine metabolism";"Pentose phosphate pathway";"5-Phosphoribose 1-diphosphate biosynthesis" lcl|NW_020311418.1_prot_XP_020709691.1_8040 3 Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807 "Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism" lcl|NW_020311315.1_prot_XP_020711116.1_3117 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311971.1_prot_XP_012263595.1_16064 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311988.1_prot_XP_012269118.1_20586 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311349.1_prot_XP_012251149.1_5206 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311984.1_prot_XP_012254573.1_19994 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311331.1_prot_XP_012264321.1_4085 4 Reactome: R-HSA-445095;Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-6807878 "Interaction between L1 and Ankyrins";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"COPI-mediated anterograde transport" lcl|NW_020311976.1_prot_XP_012253524.1_17326 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311959.1_prot_XP_012254240.1_13204 1 Reactome: R-HSA-197264 "Nicotinamide salvaging" lcl|NW_020311955.1_prot_XP_012265479.1_12431 6 Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-6791226 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311299.1_prot_XP_012263254.1_1423 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311978.1_prot_XP_012257893.1_18187 3 Reactome: R-HSA-1614603;Reactome: R-HSA-1614558;Reactome: R-HSA-2408508 "Cysteine formation from homocysteine";"Degradation of cysteine and homocysteine";"Metabolism of ingested SeMet, Sec, MeSec into H2Se" lcl|NW_020311932.1_prot_XP_012257425.1_10712 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" lcl|NW_020311373.1_prot_XP_020710375.1_6408 1 Reactome: R-HSA-111957 "Cam-PDE 1 activation" lcl|NW_020311971.1_prot_XP_012263615.1_16071 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311982.1_prot_XP_012258368.1_19209 5 MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.10 "Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism" lcl|NW_020311974.1_prot_XP_020709396.1_16790 10 MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-5667;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.15;Reactome: R-HSA-1483166;MetaCyc: PWY-8055;MetaCyc: PWY-8053;KEGG: 00564+2.3.1.15;MetaCyc: PWY-7411 "Anandamide biosynthesis I";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Synthesis of PA";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"Glycerophospholipid metabolism";"Phosphatidate biosynthesis (yeast)" lcl|NW_020311313.1_prot_XP_012261803.1_2885 1 Reactome: R-HSA-8849932 "Synaptic adhesion-like molecules" lcl|NW_020311918.1_prot_XP_012265041.1_10471 6 Reactome: R-HSA-196807;MetaCyc: PWY-5653;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5381;KEGG: 00760+6.3.5.1;MetaCyc: PWY-7761 "Nicotinate metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)" lcl|NW_020311887.1_prot_XP_012267022.1_10129 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311389.1_prot_XP_012250639.1_7007 1 Reactome: R-HSA-611105 "Respiratory electron transport" lcl|NW_020311982.1_prot_XP_012258468.1_19232 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311302.1_prot_XP_025602690.1_1710 4 Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-3769402 "Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex" lcl|NW_020311940.1_prot_XP_012265538.1_11334 2 Reactome: R-HSA-2142691;Reactome: R-HSA-2142700 "Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)" lcl|NW_020311377.1_prot_XP_012268462.1_6579 6 Reactome: R-HSA-4086398;Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-8951430;Reactome: R-HSA-4411364 "Ca2+ pathway";"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters" lcl|NW_020311298.1_prot_XP_020706233.1_1143 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311965.1_prot_XP_012260244.1_14192 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" lcl|NW_020311933.1_prot_XP_012252875.1_10759 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311373.1_prot_XP_012266668.1_6494 2 Reactome: R-HSA-3238698;Reactome: R-HSA-373080 "WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)" lcl|NW_020311439.1_prot_XP_012264168.1_8841 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311499.1_prot_XP_012269265.1_9559 3 Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533 "Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis" lcl|NW_020311966.1_prot_XP_012256572.1_14836 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311312.1_prot_XP_012266806.1_2671 5 MetaCyc: PWY-8043;Reactome: R-HSA-5579006;KEGG: 00270+6.3.2.3;Reactome: R-HSA-174403;KEGG: 00480+6.3.2.3 "Ophthalmate biosynthesis";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Cysteine and methionine metabolism";"Glutathione synthesis and recycling";"Glutathione metabolism" lcl|NW_020311915.1_prot_XP_020710081.1_10162 2 Reactome: R-HSA-975957;Reactome: R-HSA-9010553 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311323.1_prot_XP_012268084.1_3492 1 MetaCyc: PWY-7379 "Mrna capping II" lcl|NW_020311313.1_prot_XP_020709861.1_2852 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311978.1_prot_XP_012257900.1_18343 13 MetaCyc: PWY-5537;MetaCyc: PWY-7384;Reactome: R-HSA-71403;KEGG: 00660+6.2.1.5;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-5690;MetaCyc: PWY-6728;MetaCyc: PWY-6969;MetaCyc: PWY-5538;MetaCyc: PWY-5913;KEGG: 00020+6.2.1.5;KEGG: 00640+6.2.1.5 "Pyruvate fermentation to acetate V";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citric acid cycle (TCA cycle)";"C5-Branched dibasic acid metabolism";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"Propanoate metabolism" lcl|NW_020311380.1_prot_XP_012261408.1_6675 9 Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-6804756 "HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Regulation of TP53 Activity through Phosphorylation" lcl|NW_020311286.1_prot_XP_012256315.1_64 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311953.1_prot_XP_012260590.1_12265 4 Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-77595 "RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs" lcl|NW_020311975.1_prot_XP_020706658.1_16971 4 Reactome: R-HSA-196108;Reactome: R-HSA-5579026;Reactome: R-HSA-211976;Reactome: R-HSA-2395516 "Pregnenolone biosynthesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Endogenous sterols";"Electron transport from NADPH to Ferredoxin" lcl|NW_020311983.1_prot_XP_020707865.1_19714 2 KEGG: 00450+6.1.1.10;KEGG: 00970+6.1.1.10 "Selenocompound metabolism";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311381.1_prot_XP_012252339.1_6839 52 Reactome: R-HSA-167287;Reactome: R-HSA-5617472;Reactome: R-HSA-167243;Reactome: R-HSA-749476;Reactome: R-HSA-73776;Reactome: R-HSA-5578749;Reactome: R-HSA-167238;Reactome: R-HSA-167162;Reactome: R-HSA-1834949;Reactome: R-HSA-5250924;Reactome: R-HSA-73780;Reactome: R-HSA-203927;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-73772;Reactome: R-HSA-75953;Reactome: R-HSA-8851708;Reactome: R-HSA-77075;Reactome: R-HSA-72165;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-72086;Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-73779;Reactome: R-HSA-5601884;Reactome: R-HSA-6803529;Reactome: R-HSA-6781827;Reactome: R-HSA-73863;Reactome: R-HSA-6796648;Reactome: R-HSA-76061;Reactome: R-HSA-6807505;Reactome: R-HSA-167242;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-76042;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-168325;Reactome: R-HSA-9018519;Reactome: R-HSA-76066 "HIV elongation arrest and recovery";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase II Promoter Escape";"Transcriptional regulation by small RNAs";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II HIV Promoter Escape";"Cytosolic sensors of pathogen-associated DNA";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Chain Elongation";"MicroRNA (miRNA) biogenesis";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase I Promoter Escape";"RNA Polymerase II Transcription Initiation";"Signaling by FGFR2 IIIa TM";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"mRNA Capping";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"PIWI-interacting RNA (piRNA) biogenesis";"FGFR2 alternative splicing";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Transcription Termination";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA polymerase II transcribes snRNA genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Viral Messenger RNA Synthesis";"Estrogen-dependent gene expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" lcl|NW_020311408.1_prot_XP_020710017.1_7800 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311964.1_prot_XP_012261972.1_13879 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311989.1_prot_XP_012263191.1_20772 12 MetaCyc: PWY-5857;MetaCyc: PWY-5873;MetaCyc: PWY-5855;MetaCyc: PWY-6708;KEGG: 00130+2.5.1.39;MetaCyc: PWY-5870;MetaCyc: PWY-6978;Reactome: R-HSA-2142789;MetaCyc: PWY-5856;MetaCyc: PWY-5872;MetaCyc: PWY-5871;Reactome: R-HSA-1268020 "Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-8 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Mitochondrial protein import" lcl|NW_020311306.1_prot_XP_012265846.1_2158 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311382.1_prot_XP_012268033.1_6873 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311961.1_prot_XP_012262473.1_13349 9 Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167161;Reactome: R-HSA-6807505;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-73776 "RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HIV Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape" lcl|NW_020311988.1_prot_XP_020709726.1_20703 3 Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081 "Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling" lcl|NW_020311313.1_prot_XP_012261811.1_2817 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" lcl|NW_020311980.1_prot_XP_012261318.1_18859 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311296.1_prot_XP_012262830.1_1058 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311943.1_prot_XP_012254702.1_11617 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311980.1_prot_XP_012261313.1_18858 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311306.1_prot_XP_012251696.1_2134 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311971.1_prot_XP_025602667.1_15857 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311292.1_prot_XP_012252423.1_652 3 Reactome: R-HSA-6807004;Reactome: R-HSA-6798695;Reactome: R-HSA-202427 "Negative regulation of MET activity";"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains" lcl|NW_020311293.1_prot_XP_012251511.1_842 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311968.1_prot_XP_012253088.1_15434 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" lcl|NW_020311396.1_prot_XP_020712530.1_7268 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311291.1_prot_XP_012259519.1_474 1 Reactome: R-HSA-1660499 "Synthesis of PIPs at the plasma membrane" lcl|NW_020311971.1_prot_XP_020710492.1_16030 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311983.1_prot_XP_012267148.1_19454 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" lcl|NW_020311955.1_prot_XP_012265476.1_12406 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311990.1_prot_XP_012266465.1_20856 2 KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1 "Purine metabolism";"Pentose phosphate pathway" lcl|NW_020311332.1_prot_XP_012268552.1_4115 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" lcl|NW_020311396.1_prot_XP_012269546.1_7235 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311381.1_prot_XP_012252308.1_6794 11 Reactome: R-HSA-164378;Reactome: R-HSA-432040;Reactome: R-HSA-418555;Reactome: R-HSA-418594;Reactome: R-HSA-163359;Reactome: R-HSA-163615;Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-418597;Reactome: R-HSA-5610787 "PKA activation in glucagon signalling";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (s) signalling events";"G alpha (i) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation";"Adenylate cyclase activating pathway";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"G alpha (z) signalling events";"Hedgehog 'off' state" lcl|NW_020311980.1_prot_XP_012261332.1_18782 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311373.1_prot_XP_025601919.1_6423 7 Reactome: R-HSA-2894862;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-2691232 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants" lcl|NW_020311995.1_prot_XP_020708155.1_21930 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311327.1_prot_XP_012263475.1_3886 2 Reactome: R-HSA-8963888;Reactome: R-HSA-8866423 "Chylomicron assembly";"VLDL assembly" lcl|NW_020311361.1_prot_XP_012261501.1_5828 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311953.1_prot_XP_012260512.1_12248 5 Reactome: R-HSA-432722;Reactome: R-HSA-8856828;Reactome: R-HSA-6811440;Reactome: R-HSA-8856825;Reactome: R-HSA-6798695 "Golgi Associated Vesicle Biogenesis";"Clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network";"Cargo recognition for clathrin-mediated endocytosis";"Neutrophil degranulation" lcl|NW_020311935.1_prot_XP_012258965.1_10962 7 Reactome: R-HSA-389661;Reactome: R-HSA-70268;Reactome: R-HSA-204174;KEGG: 00020+1.2.4.1;KEGG: 00620+1.2.4.1;KEGG: 00010+1.2.4.1;Reactome: R-HSA-5362517 "Glyoxylate metabolism and glycine degradation";"Pyruvate metabolism";"Regulation of pyruvate dehydrogenase (PDH) complex";"Citrate cycle (TCA cycle)";"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Signaling by Retinoic Acid" lcl|NW_020311940.1_prot_XP_012265669.1_11266 18 MetaCyc: PWY-5084;KEGG: 00620+1.8.1.4;Reactome: R-HSA-5362517;KEGG: 00010+1.8.1.4;KEGG: 00260+1.8.1.4;Reactome: R-HSA-6783984;MetaCyc: PWY-5046;Reactome: R-HSA-389661;KEGG: 00380+1.8.1.4;Reactome: R-HSA-70895;KEGG: 00020+1.8.1.4;KEGG: 00280+1.8.1.4;Reactome: R-HSA-204174;KEGG: 00640+1.8.1.4;Reactome: R-HSA-71064;Reactome: R-HSA-71403;Reactome: R-HSA-70268;KEGG: 00310+1.8.1.4 "2-oxoglutarate decarboxylation to succinyl-CoA";"Pyruvate metabolism";"Signaling by Retinoic Acid";"Glycolysis / Gluconeogenesis";"Glycine, serine and threonine metabolism";"Glycine degradation";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism";"Branched-chain amino acid catabolism";"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine degradation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Propanoate metabolism";"Lysine catabolism";"Citric acid cycle (TCA cycle)";"Pyruvate metabolism";"Lysine degradation" lcl|NW_020311940.1_prot_XP_025602342.1_11178 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311961.1_prot_XP_012262695.1_13283 13 Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation" lcl|NW_020311965.1_prot_XP_012260230.1_14173 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311955.1_prot_XP_020711185.1_12402 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311962.1_prot_XP_020706747.1_13767 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311294.1_prot_XP_020710994.1_914 2 Reactome: R-HSA-1799339;Reactome: R-HSA-381038 "SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes" lcl|NW_020311979.1_prot_XP_012259508.1_18531 3 Reactome: R-HSA-5358493;MetaCyc: PWY-6482;MetaCyc: PWY-7546 "Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)" lcl|NW_020311393.1_prot_XP_012265732.1_7109 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311300.1_prot_XP_012253145.1_1498 7 Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942 "Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition" lcl|NW_020311401.1_prot_XP_020707669.1_7678 9 MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-6902;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00513+3.2.1.52 "Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Various types of N-glycan biosynthesis" lcl|NW_020311977.1_prot_XP_012264105.1_17763 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311994.1_prot_XP_025603004.1_21728 2 KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600 "Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" lcl|NW_020311975.1_prot_XP_012253942.1_17072 1 Reactome: R-HSA-212300 "PRC2 methylates histones and DNA" lcl|NW_020311360.1_prot_XP_020706631.1_5777 8 Reactome: R-HSA-70171;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00051+2.7.1.1 "Glycolysis";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Glycolysis / Gluconeogenesis";"Galactose metabolism";"Fructose and mannose metabolism" lcl|NW_020311940.1_prot_XP_012265575.1_11213 7 KEGG: 00500+2.4.1.25;MetaCyc: PWY-6737;MetaCyc: PWY-5941;Reactome: R-HSA-70221;Reactome: R-HSA-6798695;MetaCyc: PWY-6724;MetaCyc: PWY-7238 "Starch and sucrose metabolism";"Starch degradation V";"Glycogen degradation II";"Glycogen breakdown (glycogenolysis)";"Neutrophil degranulation";"Starch degradation II";"Sucrose biosynthesis II" lcl|NW_020311971.1_prot_XP_012260927.1_15961 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311411.1_prot_XP_012256336.1_7852 56 Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-174084;Reactome: R-HSA-5687128;Reactome: R-HSA-75815 "Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Regulation of RAS by GAPs";"G2/M Checkpoints";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D" lcl|NW_020311337.1_prot_XP_025601761.1_4432 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311331.1_prot_XP_012264305.1_4067 10 KEGG: 00562+2.7.1.134+2.7.1.159;MetaCyc: PWY-6365;KEGG: 04070+2.7.1.159;Reactome: R-HSA-1855167;MetaCyc: PWY-6366;MetaCyc: PWY-4661;MetaCyc: PWY-6554;Reactome: R-HSA-1855204;MetaCyc: PWY-6362;Reactome: R-HSA-983231 "Inositol phosphate metabolism";"D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol";"D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"Synthesis of IP3 and IP4 in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Factors involved in megakaryocyte development and platelet production" lcl|NW_020311978.1_prot_XP_012257951.1_18370 13 KEGG: 00720+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-6728;MetaCyc: PWY-5392;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-7384;MetaCyc: PWY-5537;Reactome: R-HSA-71403 "Carbon fixation pathways in prokaryotes";"C5-Branched dibasic acid metabolism";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Reductive TCA cycle II";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Pyruvate fermentation to acetate V";"Citric acid cycle (TCA cycle)" lcl|NW_020311298.1_prot_XP_012269911.1_1280 6 Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-429958;Reactome: R-HSA-380994 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress" lcl|NW_020311311.1_prot_XP_020706398.1_2531 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311988.1_prot_XP_012261205.1_20664 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311373.1_prot_XP_012266729.1_6458 8 KEGG: 04714+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Signaling by Hippo";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway" lcl|NW_020311967.1_prot_XP_025602602.1_15248 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311942.1_prot_XP_012252523.1_11469 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311961.1_prot_XP_012262683.1_13358 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311978.1_prot_XP_012258049.1_18289 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311980.1_prot_XP_012261358.1_18870 2 MetaCyc: PWY-6558;Reactome: R-HSA-2022928 "Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis" lcl|NW_020311980.1_prot_XP_020709753.1_18777 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311966.1_prot_XP_012251738.1_14570 3 Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955 "Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation" lcl|NW_020311971.1_prot_XP_020709623.1_15988 2 Reactome: R-HSA-201722;Reactome: R-HSA-3769402 "Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex" lcl|NW_020311978.1_prot_XP_012257760.1_18198 10 MetaCyc: PWY-5484;KEGG: 00051+5.3.1.1;Reactome: R-HSA-70171;KEGG: 00562+5.3.1.1;KEGG: 00710+5.3.1.1;KEGG: 00010+5.3.1.1;MetaCyc: PWY-7003;MetaCyc: PWY-6142;Reactome: R-HSA-70263;MetaCyc: PWY-1042 "Glycolysis II (from fructose 6-phosphate)";"Fructose and mannose metabolism";"Glycolysis";"Inositol phosphate metabolism";"Carbon fixation in photosynthetic organisms";"Glycolysis / Gluconeogenesis";"Glycerol degradation to butanol";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Gluconeogenesis";"Glycolysis IV (plant cytosol)" lcl|NW_020311329.1_prot_XP_020706135.1_3966 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311974.1_prot_XP_012259902.1_16847 56 Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-1236978;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5689880 "CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"G2/M Checkpoints";"Regulation of RAS by GAPs";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Ub-specific processing proteases" lcl|NW_020311292.1_prot_XP_020706841.1_664 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311977.1_prot_XP_020710678.1_17856 6 MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733 "Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis" lcl|NW_020311339.1_prot_XP_012253624.1_4656 6 Reactome: R-HSA-5654712;Reactome: R-HSA-9028731;Reactome: R-HSA-5654693;Reactome: R-HSA-5654706;Reactome: R-HSA-5673001;Reactome: R-HSA-5654700 "FRS-mediated FGFR4 signaling";"Activated NTRK2 signals through FRS2 and FRS3";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR3 signaling";"RAF/MAP kinase cascade";"FRS-mediated FGFR2 signaling" lcl|NW_020311347.1_prot_XP_012266156.1_5073 5 Reactome: R-HSA-983170;Reactome: R-HSA-1655829;Reactome: R-HSA-204005;Reactome: R-HSA-5694530;Reactome: R-HSA-2132295 "Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"COPII-mediated vesicle transport";"Cargo concentration in the ER";"MHC class II antigen presentation" lcl|NW_020311955.1_prot_XP_012265365.1_12424 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311966.1_prot_XP_020706992.1_14432 6 MetaCyc: PWY-4381;MetaCyc: PWY-5744;MetaCyc: PWY-5743;MetaCyc: PWY-5789;Reactome: R-HSA-196780;MetaCyc: PWY-6722 "Fatty acid biosynthesis initiation (bacteria and plants)";"Glyoxylate assimilation";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Biotin transport and metabolism";"Candicidin biosynthesis" lcl|NW_020311977.1_prot_XP_012263674.1_17795 17 Reactome: R-HSA-3371599;Reactome: R-HSA-163765;Reactome: R-HSA-2426168;Reactome: R-HSA-200425;KEGG: 00254+6.4.1.2;KEGG: 00640+6.4.1.2;Reactome: R-HSA-196780;MetaCyc: PWY-6679;MetaCyc: PWY-4381;MetaCyc: PWY-5789;MetaCyc: PWY-5743;KEGG: 00620+6.4.1.2;MetaCyc: PWY-6722;KEGG: 00061+6.4.1.2;MetaCyc: PWY-5744;MetaCyc: PWY-5966-1;KEGG: 00720+6.4.1.2 "Defective HLCS causes multiple carboxylase deficiency";"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)";"Carnitine metabolism";"Aflatoxin biosynthesis";"Propanoate metabolism";"Biotin transport and metabolism";"Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"3-hydroxypropanoate cycle";"Pyruvate metabolism";"Candicidin biosynthesis";"Fatty acid biosynthesis";"Glyoxylate assimilation";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Carbon fixation pathways in prokaryotes" lcl|NW_020311286.1_prot_XP_012257177.1_138 6 Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107 "Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism" lcl|NW_020311966.1_prot_XP_012256743.1_15081 2 Reactome: R-HSA-2024096;Reactome: R-HSA-2206307 "HS-GAG degradation";"MPS IIIA - Sanfilippo syndrome A" lcl|NW_020311360.1_prot_XP_012251615.1_5763 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" lcl|NW_020311977.1_prot_XP_012263845.1_17741 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" lcl|NW_020311965.1_prot_XP_012259996.1_14266 1 Reactome: R-HSA-419771 "Opsins" lcl|NW_020311992.1_prot_XP_012266364.1_21149 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311962.1_prot_XP_012252075.1_13695 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311970.1_prot_XP_025602632.1_15808 5 Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977 "ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling" lcl|NW_020311446.1_prot_XP_012261107.1_8937 2 KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710 "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311993.1_prot_XP_012262637.1_21372 14 Reactome: R-HSA-71403;KEGG: 00650+1.3.5.1;Reactome: R-HSA-611105;MetaCyc: PWY-3781;MetaCyc: PWY-7279;KEGG: 00020+1.3.5.1;KEGG: 00190+1.3.5.1;MetaCyc: PWY-6728;MetaCyc: PWY-5690;KEGG: 00720+1.3.5.1;MetaCyc: PWY-561;MetaCyc: PWY-4302;MetaCyc: PWY-7254;MetaCyc: PWY-6969 "Citric acid cycle (TCA cycle)";"Butanoate metabolism";"Respiratory electron transport";"Aerobic respiration I (cytochrome c)";"Aerobic respiration II (cytochrome c) (yeast)";"Citrate cycle (TCA cycle)";"Oxidative phosphorylation";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Carbon fixation pathways in prokaryotes";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration III (alternative oxidase pathway)";"TCA cycle VII (acetate-producers)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)" lcl|NW_020311373.1_prot_XP_012251292.1_6496 2 Reactome: R-HSA-373080;Reactome: R-HSA-3238698 "Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking" lcl|NW_020311424.1_prot_XP_012255388.1_8228 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" lcl|NW_020311959.1_prot_XP_020710132.1_13102 1 Reactome: R-HSA-196108 "Pregnenolone biosynthesis" lcl|NW_020311513.1_prot_XP_020711445.1_9714 1 Reactome: R-HSA-2142789 "Ubiquinol biosynthesis" lcl|NW_020311309.1_prot_XP_012259041.1_2271 8 Reactome: R-HSA-71336;MetaCyc: PWY-1861;MetaCyc: PWY-5723;KEGG: 00710+5.3.1.6;Reactome: R-HSA-5659996;KEGG: 00030+5.3.1.6;Reactome: R-HSA-6791461;KEGG: 00051+5.3.1.6 "Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Rubisco shunt";"Carbon fixation in photosynthetic organisms";"RPIA deficiency: failed conversion of R5P to RU5P";"Pentose phosphate pathway";"RPIA deficiency: failed conversion of RU5P to R5P";"Fructose and mannose metabolism" lcl|NW_020311976.1_prot_XP_012253504.1_17294 14 Reactome: R-HSA-3769402;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-5687128;Reactome: R-HSA-69273;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2173788;Reactome: R-HSA-450520;Reactome: R-HSA-9634638;Reactome: R-HSA-9648025;Reactome: R-HSA-165054 "Deactivation of the beta-catenin transactivating complex";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"MAPK6/MAPK4 signaling";"Cyclin A/B1/B2 associated events during G2/M transition";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Downregulation of TGF-beta receptor signaling";"HuR (ELAVL1) binds and stabilizes mRNA";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"EML4 and NUDC in mitotic spindle formation";"Rev-mediated nuclear export of HIV RNA" lcl|NW_020311975.1_prot_XP_020707596.1_17032 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311950.1_prot_XP_012264348.1_12145 4 Reactome: R-HSA-1268020;Reactome: R-HSA-8949613;Reactome: R-HSA-8950505;Reactome: R-HSA-3371453 "Mitochondrial protein import";"Cristae formation";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Regulation of HSF1-mediated heat shock response" lcl|NW_020311334.1_prot_XP_020711372.1_4376 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311312.1_prot_XP_012266811.1_2662 7 MetaCyc: PWY-5265;MetaCyc: PWY-6471;Reactome: R-HSA-446193;MetaCyc: PWY-6470;KEGG: 00510+2.7.8.15;Reactome: R-HSA-4549356;KEGG: 00550+2.7.8.13 "Peptidoglycan biosynthesis II (staphylococci)";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis V (beta-lactam resistance)";"N-Glycan biosynthesis";"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2";"Peptidoglycan biosynthesis" lcl|NW_020311969.1_prot_XP_020710970.1_15561 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" lcl|NW_020311993.1_prot_XP_012262938.1_21379 3 Reactome: R-HSA-2022928;MetaCyc: PWY-6558;KEGG: 00534+5.1.3.17 "HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin" lcl|NW_020311304.1_prot_XP_012261144.1_1758 5 Reactome: R-HSA-6807004;Reactome: R-HSA-8856828;Reactome: R-HSA-8875360;Reactome: R-HSA-8856825;Reactome: R-HSA-182971 "Negative regulation of MET activity";"Clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation" lcl|NW_020311988.1_prot_XP_020706163.1_20472 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" lcl|NW_020311984.1_prot_XP_020707616.1_20011 1 Reactome: R-HSA-400253 "Circadian Clock" lcl|NW_020311513.1_prot_XP_012266195.2_9896 6 KEGG: 00010+5.4.2.11;MetaCyc: PWY-1622;KEGG: 00680+5.4.2.11;KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;MetaCyc: PWY-5484 "Glycolysis / Gluconeogenesis";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Glycolysis II (from fructose 6-phosphate)" lcl|NW_020311975.1_prot_XP_012253479.1_17025 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" lcl|NW_020311978.1_prot_XP_025602790.1_18039 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" lcl|NW_020311941.1_prot_XP_020707099.1_11404 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311957.1_prot_XP_012263401.1_12823 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311367.1_prot_XP_012258937.1_6091 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311286.1_prot_XP_012256439.1_226 5 KEGG: 00052+2.7.1.6;KEGG: 00520+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6527;MetaCyc: PWY-6317 "Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"D-galactose detoxification";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)" lcl|NW_020311959.1_prot_XP_012262442.1_13134 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311948.1_prot_XP_012253567.1_11994 12 KEGG: 00680+4.1.2.13;MetaCyc: PWY-6142;Reactome: R-HSA-70263;MetaCyc: PWY-1042;KEGG: 00710+4.1.2.13;MetaCyc: PWY-5484;Reactome: R-HSA-70171;MetaCyc: PWY-1861;KEGG: 00030+4.1.2.13;KEGG: 00051+4.1.2.13;MetaCyc: PWY-7385;KEGG: 00010+4.1.2.13 "Methane metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Carbon fixation in photosynthetic organisms";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"Fructose and mannose metabolism";"1,3-propanediol biosynthesis (engineered)";"Glycolysis / Gluconeogenesis" lcl|NW_020311331.1_prot_XP_012264324.1_4090 2 KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685 "Glutathione metabolism";"Detoxification of Reactive Oxygen Species" lcl|NW_020311993.1_prot_XP_020710401.1_21399 2 Reactome: R-HSA-6790901;Reactome: R-HSA-8869496 "rRNA modification in the nucleus and cytosol";"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" lcl|NW_020311985.1_prot_XP_012265176.1_20213 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" lcl|NW_020311978.1_prot_XP_020708673.1_18123 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311985.1_prot_XP_012265230.1_20232 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311331.1_prot_XP_012264301.1_4077 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311984.1_prot_XP_012254497.1_19918 9 Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-73776;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-73779 "HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311397.1_prot_XP_012258191.1_7294 3 Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311973.1_prot_XP_012258624.1_16478 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311432.1_prot_XP_025602079.1_8402 8 KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Human papillomavirus infection";"Activation of RAC1";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311309.1_prot_XP_020709033.1_2364 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311332.1_prot_XP_012268528.1_4108 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311968.1_prot_XP_012267641.1_15381 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" lcl|NW_020311306.1_prot_XP_012265896.1_2146 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" lcl|NW_020311955.1_prot_XP_012265392.1_12415 1 KEGG: 04150+2.7.11.24 "mTOR signaling pathway" lcl|NW_020311966.1_prot_XP_020708274.1_15124 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311292.1_prot_XP_012252507.1_579 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311977.1_prot_XP_012263699.1_17854 6 MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463 "Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis" lcl|NW_020311419.1_prot_XP_012254067.2_8089 3 Reactome: R-HSA-749476;Reactome: R-HSA-6807505;Reactome: R-HSA-76071 "RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" lcl|NW_020311940.1_prot_XP_020711230.1_11181 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311361.1_prot_XP_012261556.1_5808 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311948.1_prot_XP_020707196.1_12029 7 KEGG: 00230+2.4.2.14;MetaCyc: PWY-6121;MetaCyc: PWY-6277;Reactome: R-HSA-73817;MetaCyc: PWY-7282;MetaCyc: PWY-6122;KEGG: 00250+2.4.2.14 "Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311419.1_prot_XP_012254063.1_8076 1 Reactome: R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" lcl|NW_020311298.1_prot_XP_020706238.1_1136 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311966.1_prot_XP_012252949.1_14430 6 MetaCyc: PWY-5789;Reactome: R-HSA-196780;MetaCyc: PWY-6722;MetaCyc: PWY-4381;MetaCyc: PWY-5744;MetaCyc: PWY-5743 "3-hydroxypropanoate/4-hydroxybutanate cycle";"Biotin transport and metabolism";"Candicidin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Glyoxylate assimilation";"3-hydroxypropanoate cycle" lcl|NW_020311978.1_prot_XP_012257864.1_18094 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" lcl|NW_020311977.1_prot_XP_020710685.1_17719 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" lcl|NW_020311967.1_prot_XP_020707519.1_15327 6 Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-5685938 "Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Single Strand Annealing (SSA)" lcl|NW_020311479.1_prot_XP_012253340.1_9456 12 MetaCyc: PWY-5132;MetaCyc: PWY-5133;MetaCyc: PWY-6672;MetaCyc: PWY-5108;KEGG: 00630+6.2.1.1;KEGG: 00620+6.2.1.1;MetaCyc: PWY-7118;MetaCyc: PWY-7857;KEGG: 00680+6.2.1.1;KEGG: 00720+6.2.1.1;KEGG: 00010+6.2.1.1;KEGG: 00640+6.2.1.1 "Lupulone and humulone biosynthesis";"Colupulone and cohumulone biosynthesis";"Cis-genanyl-coa degradation";"L-isoleucine biosynthesis V";"Glyoxylate and dicarboxylate metabolism";"Pyruvate metabolism";"Chitin degradation to ethanol";"Adlupulone and adhumulone biosynthesis";"Methane metabolism";"Carbon fixation pathways in prokaryotes";"Glycolysis / Gluconeogenesis";"Propanoate metabolism" lcl|NW_020311959.1_prot_XP_012259592.1_13174 4 Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" lcl|NW_020311320.1_prot_XP_025603088.1_3346 6 Reactome: R-HSA-446210;MetaCyc: PWY-5514;KEGG: 00520+5.4.2.3;KEGG: 00520+5.4.2.10;MetaCyc: PWY-6906;MetaCyc: PWY-6749 "Synthesis of UDP-N-acetyl-glucosamine";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Amino sugar and nucleotide sugar metabolism";"Amino sugar and nucleotide sugar metabolism";"Chitin derivatives degradation";"CMP-legionaminate biosynthesis I" lcl|NW_020311965.1_prot_XP_012259862.1_14191 26 Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-380320;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-437239;Reactome: R-HSA-3371497;Reactome: R-HSA-5617833;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-389960;Reactome: R-HSA-389977;Reactome: R-HSA-1445148;Reactome: R-HSA-190861;Reactome: R-HSA-9609736;Reactome: R-HSA-190840 "Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"HCMV Early Events";"Recruitment of NuMA to mitotic centrosomes";"Separation of Sister Chromatids";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Cilium Assembly";"Kinesins";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Formation of tubulin folding intermediates by CCT/TriC";"Post-chaperonin tubulin folding pathway";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Gap junction assembly";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" lcl|NW_020311324.1_prot_XP_012269359.1_3564 5 MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902;Reactome: R-HSA-189085 "Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)";"Digestion of dietary carbohydrate" lcl|NW_020311318.1_prot_XP_012253595.1_3281 1 Reactome: R-HSA-68962 "Activation of the pre-replicative complex" lcl|NW_020311983.1_prot_XP_012255539.1_19647 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311372.1_prot_XP_012268401.1_6333 2 KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557 "T cell receptor signaling pathway";"Signaling by SCF-KIT" lcl|NW_020311961.1_prot_XP_020710230.1_13521 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311967.1_prot_XP_020707514.1_15281 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311976.1_prot_XP_012253654.2_17242 2 Reactome: R-HSA-8866904;Reactome: R-HSA-8866907 "Negative regulation of activity of TFAP2 (AP-2) family transcription factors";"Activation of the TFAP2 (AP-2) family of transcription factors" lcl|NW_020311386.1_prot_XP_012268140.1_6925 7 MetaCyc: PWY-6610;Reactome: R-HSA-74217;Reactome: R-HSA-6798695;KEGG: 00230+2.4.2.7;MetaCyc: PWY-7807;MetaCyc: PWY-7805;MetaCyc: PWY-6605 "Adenine salvage";"Purine salvage";"Neutrophil degranulation";"Purine metabolism";"Glyphosate degradation III";"(aminomethyl)phosphonate degradation";"Adenine and adenosine salvage II" lcl|NW_020311982.1_prot_XP_012258295.1_19289 26 Reactome: R-HSA-3371497;Reactome: R-HSA-5617833;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-9619483;Reactome: R-HSA-6807878;Reactome: R-HSA-389960;Reactome: R-HSA-389977;Reactome: R-HSA-1445148;Reactome: R-HSA-190861;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-380320;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-437239 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Cilium Assembly";"Resolution of Sister Chromatid Cohesion";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Activation of AMPK downstream of NMDARs";"COPI-mediated anterograde transport";"Formation of tubulin folding intermediates by CCT/TriC";"Post-chaperonin tubulin folding pathway";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Gap junction assembly";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"HCMV Early Events";"Recruitment of NuMA to mitotic centrosomes";"Separation of Sister Chromatids";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Recycling pathway of L1" lcl|NW_020311309.1_prot_XP_020709070.1_2395 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311327.1_prot_XP_012252859.1_3788 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311980.1_prot_XP_012261341.1_18812 2 Reactome: R-HSA-5357956;Reactome: R-HSA-5357905 "TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling" lcl|NW_020311472.1_prot_XP_020712450.1_9363 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311526.1_prot_XP_020712510.1_9954 5 Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-176187 "Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress" lcl|NW_020311416.1_prot_XP_012253690.1_7938 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311349.1_prot_XP_020706483.1_5272 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311957.1_prot_XP_012263336.1_12843 5 KEGG: 04150+2.7.11.24;Reactome: R-HSA-4420097;Reactome: R-HSA-171007;Reactome: R-HSA-376172;Reactome: R-HSA-168638 "mTOR signaling pathway";"VEGFA-VEGFR2 Pathway";"p38MAPK events";"DSCAM interactions";"NOD1/2 Signaling Pathway" lcl|NW_020311925.1_prot_XP_020706886.1_10538 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311965.1_prot_XP_012260254.1_14132 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311974.1_prot_XP_012259783.1_16737 3 Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482 "Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events" lcl|NW_020311327.1_prot_XP_012252829.1_3759 13 Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-192823 "Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation" lcl|NW_020311298.1_prot_XP_012250558.1_1129 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311401.1_prot_XP_012254952.1_7596 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311313.1_prot_XP_012261818.1_2816 16 Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557 "Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis" lcl|NW_020311393.1_prot_XP_012265706.1_7166 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311356.1_prot_XP_012267055.1_5571 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311976.1_prot_XP_012253604.1_17286 2 KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749 "Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I" lcl|NW_020311976.1_prot_XP_012257023.1_17398 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311965.1_prot_XP_012259819.1_14165 4 Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-8856828;Reactome: R-HSA-5663213 "Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis";"RHO GTPases Activate WASPs and WAVEs" lcl|NW_020311334.1_prot_XP_020711362.1_4379 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311619.1_prot_XP_012260741.1_10080 5 MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;MetaCyc: PWY-6902;Reactome: R-HSA-189085 "Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Digestion of dietary carbohydrate" lcl|NW_020311472.1_prot_XP_012269197.1_9309 9 Reactome: R-HSA-167161;Reactome: R-HSA-6807505;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-76042;Reactome: R-HSA-73779 "HIV Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311926.1_prot_XP_020706364.1_10597 1 Reactome: R-HSA-418886 "Netrin mediated repulsion signals" lcl|NW_020311968.1_prot_XP_012253056.1_15453 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311978.1_prot_XP_012257825.1_18043 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311313.1_prot_XP_020709863.1_2843 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311966.1_prot_XP_012256966.1_14933 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" lcl|NW_020311984.1_prot_XP_012267683.1_20156 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311984.1_prot_XP_012254668.1_19846 4 Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-3769402 "NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex" lcl|NW_020311976.1_prot_XP_020707167.1_17212 3 KEGG: 04660+2.7.10.2;Reactome: R-HSA-4420097;Reactome: R-HSA-391160 "T cell receptor signaling pathway";"VEGFA-VEGFR2 Pathway";"Signal regulatory protein family interactions" lcl|NW_020311362.1_prot_XP_012264907.1_5860 2 KEGG: 00240+4.2.1.70;MetaCyc: PWY-6019 "Pyrimidine metabolism";"Pseudouridine degradation" lcl|NW_020311977.1_prot_XP_020710716.1_17643 1 Reactome: R-HSA-427652 "Sodium-coupled phosphate cotransporters" lcl|NW_020311993.1_prot_XP_020710385.1_21402 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" lcl|NW_020311977.1_prot_XP_020710548.1_17879 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311994.1_prot_XP_012267454.1_21785 14 Reactome: R-HSA-203927;Reactome: R-HSA-9029569;Reactome: R-HSA-4086398;Reactome: R-HSA-426486;Reactome: R-HSA-426496;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-8934593;Reactome: R-HSA-8943723;Reactome: R-HSA-9018519;Reactome: R-HSA-9022692;Reactome: R-HSA-8986944;Reactome: R-HSA-5687128 "MicroRNA (miRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Ca2+ pathway";"Small interfering RNA (siRNA) biogenesis";"Post-transcriptional silencing by small RNAs";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of RUNX1 Expression and Activity";"Regulation of PTEN mRNA translation";"Estrogen-dependent gene expression";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by MECP2";"MAPK6/MAPK4 signaling" lcl|NW_020311994.1_prot_XP_020711907.1_21746 5 KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7269;MetaCyc: PWY-5083;MetaCyc: PWY-7268 "Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)" lcl|NW_020311297.1_prot_XP_012254108.1_1093 3 KEGG: 00670+2.1.2.9;Reactome: R-HSA-5368286;KEGG: 00970+2.1.2.9 "One carbon pool by folate";"Mitochondrial translation initiation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311983.1_prot_XP_012255590.1_19665 1 Reactome: R-HSA-8964572 "Lipid particle organization" lcl|NW_020311317.1_prot_XP_012250612.1_3231 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311994.1_prot_XP_025603015.1_21784 14 Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-426486;Reactome: R-HSA-9029569;Reactome: R-HSA-203927;Reactome: R-HSA-8986944;Reactome: R-HSA-5687128;Reactome: R-HSA-9018519;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-8934593;Reactome: R-HSA-8948700 "TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"Small interfering RNA (siRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"MicroRNA (miRNA) biogenesis";"Transcriptional Regulation by MECP2";"MAPK6/MAPK4 signaling";"Estrogen-dependent gene expression";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Regulation of RUNX1 Expression and Activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation" lcl|NW_020311511.1_prot_XP_012250965.1_9657 6 MetaCyc: PWY-5663;MetaCyc: PWY-6983;KEGG: 00790+4.2.3.12;MetaCyc: PWY-7442;Reactome: R-HSA-1474151;MetaCyc: PWY-5664 "Erythro-tetrahydrobiopterin biosynthesis I";"Threo-tetrahydrobiopterin biosynthesis";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis II" lcl|NW_020311292.1_prot_XP_012252408.1_553 4 KEGG: 00030+1.1.1.49;KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268;MetaCyc: PWY-8004 "Pentose phosphate pathway";"Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Entner-Doudoroff pathway I" lcl|NW_020311309.1_prot_XP_012259087.1_2265 5 KEGG: 00860+2.3.1.37;Reactome: R-HSA-189451;KEGG: 00260+2.3.1.37;MetaCyc: PWY-5189;MetaCyc: PWY-7536 "Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Glycine, serine and threonine metabolism";"Tetrapyrrole biosynthesis II (from glycine)";"2-amino-3-hydroxycyclopent-2-enone biosynthesis" lcl|NW_020311346.1_prot_XP_020710323.1_5007 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311514.1_prot_XP_012265811.1_9927 1 Reactome: R-HSA-9640463 "Wax biosynthesis" lcl|NW_020311964.1_prot_XP_025602533.1_13912 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311432.1_prot_XP_012268785.1_8476 6 Reactome: R-HSA-434316;Reactome: R-HSA-456926;Reactome: R-HSA-418592;Reactome: R-HSA-416476;Reactome: R-HSA-428930;Reactome: R-HSA-399997 "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"ADP signalling through P2Y purinoceptor 1";"G alpha (q) signalling events";"Thromboxane signalling through TP receptor";"Acetylcholine regulates insulin secretion" lcl|NW_020311294.1_prot_XP_020711013.1_882 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" lcl|NW_020311401.1_prot_XP_012255354.1_7649 4 Reactome: R-HSA-4641257;Reactome: R-HSA-418594;Reactome: R-HSA-201681;Reactome: R-HSA-5689880 "Degradation of AXIN";"G alpha (i) signalling events";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases" lcl|NW_020311959.1_prot_XP_020710138.1_13105 1 Reactome: R-HSA-196108 "Pregnenolone biosynthesis" lcl|NW_020311338.1_prot_XP_012262989.1_4571 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311925.1_prot_XP_020708942.1_10513 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311958.1_prot_XP_012255470.1_12979 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311988.1_prot_XP_020709699.1_20733 27 Reactome: R-HSA-168271;Reactome: R-HSA-5619107;Reactome: R-HSA-3371453;Reactome: R-HSA-4570464;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-159230;Reactome: R-HSA-168333;Reactome: R-HSA-3301854;Reactome: R-HSA-159227;Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-4085377;Reactome: R-HSA-4615885;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-1169408;Reactome: R-HSA-9609690;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-6784531;Reactome: R-HSA-4551638 "Transport of Ribonucleoproteins into the Host Nucleus";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of HSF1-mediated heat shock response";"SUMOylation of RNA binding proteins";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"Transport of the SLBP Dependant Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP independent Mature mRNA";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"SUMOylation of SUMOylation proteins";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"ISG15 antiviral mechanism";"HCMV Early Events";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"tRNA processing in the nucleus";"SUMOylation of chromatin organization proteins" lcl|NW_020311314.1_prot_XP_012252166.1_3070 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311436.1_prot_XP_012258383.1_8751 7 MetaCyc: PWY-7790;Reactome: R-HSA-500753;KEGG: 00240+4.1.1.23;MetaCyc: PWY-5686;KEGG: 00983+2.4.2.10;MetaCyc: PWY-7791;KEGG: 00240+2.4.2.10 "UMP biosynthesis II";"Pyrimidine biosynthesis";"Pyrimidine metabolism";"UMP biosynthesis I";"Drug metabolism - other enzymes";"UMP biosynthesis III";"Pyrimidine metabolism" lcl|NW_020311372.1_prot_XP_012268405.1_6334 2 KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557 "T cell receptor signaling pathway";"Signaling by SCF-KIT" lcl|NW_020311995.1_prot_XP_020708161.1_22037 9 Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-73779 "Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311373.1_prot_XP_020710376.1_6404 1 Reactome: R-HSA-111957 "Cam-PDE 1 activation" lcl|NW_020311401.1_prot_XP_020707755.1_7576 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311988.1_prot_XP_012261126.1_20708 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" lcl|NW_020311347.1_prot_XP_012266005.1_5048 3 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" lcl|NW_020311383.1_prot_XP_012251550.1_6881 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311935.1_prot_XP_012259125.1_10943 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311970.1_prot_XP_020712388.1_15617 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311302.1_prot_XP_012264541.1_1682 1 Reactome: R-HSA-189451 "Heme biosynthesis" lcl|NW_020311453.1_prot_XP_012252714.1_9061 5 MetaCyc: PWY-3341;KEGG: 00330+1.5.1.2;MetaCyc: PWY-4981;Reactome: R-HSA-8964539;MetaCyc: PWY-6344 "L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism";"L-proline biosynthesis II (from arginine)";"Glutamate and glutamine metabolism";"L-ornithine degradation II (Stickland reaction)" lcl|NW_020311424.1_prot_XP_012255438.1_8179 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311966.1_prot_XP_012256877.1_15168 20 MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7337;MetaCyc: PWY-7291;MetaCyc: PWY-6837;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7858;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7288;MetaCyc: PWY-6920;MetaCyc: PWY-7340;MetaCyc: PWY-7726;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7007;Reactome: R-HSA-9033241;MetaCyc: PWY-735;MetaCyc: PWY-7338;MetaCyc: PWY-7574;MetaCyc: PWY-7854;MetaCyc: PWY-7606 "Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"alpha-Linolenic acid metabolism";"(5Z)-dodecenoate biosynthesis II";"beta-Alanine metabolism";"Fatty acid beta-oxidation VII (yeast peroxisome)";"6-gingerol analog biosynthesis (engineered)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Propanoate metabolism";"Methyl ketone biosynthesis (engineered)";"Peroxisomal protein import";"Jasmonic acid biosynthesis";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoyl-coa degradation II";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)" lcl|NW_020311315.1_prot_XP_020711088.1_3109 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311309.1_prot_XP_012259108.1_2309 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311311.1_prot_XP_020706354.1_2479 6 Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-69052 "Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Unwinding of DNA";"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state" lcl|NW_020311985.1_prot_XP_012265221.1_20226 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311984.1_prot_XP_012254609.1_19891 2 Reactome: R-HSA-5696394;Reactome: R-HSA-5689603 "DNA Damage Recognition in GG-NER";"UCH proteinases" lcl|NW_020311977.1_prot_XP_012263686.1_17782 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" lcl|NW_020311984.1_prot_XP_020707577.1_19991 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311982.1_prot_XP_012258407.1_19203 2 Reactome: R-HSA-73980;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311401.1_prot_XP_012254899.1_7538 22 Reactome: R-HSA-195253;Reactome: R-HSA-5358747;Reactome: R-HSA-5467348;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-2500257;Reactome: R-HSA-5358751;Reactome: R-HSA-196299;Reactome: R-HSA-4641262;Reactome: R-HSA-5675221;Reactome: R-HSA-68877;Reactome: R-HSA-5358749;Reactome: R-HSA-5467340;Reactome: R-HSA-5339716;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-6811558;Reactome: R-HSA-5358752;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-432142;Reactome: R-HSA-5673000 "Degradation of beta-catenin by the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Resolution of Sister Chromatid Cohesion";"S45 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Negative regulation of MAPK pathway";"Mitotic Prometaphase";"S37 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"Misspliced GSK3beta mutants stabilize beta-catenin";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"Platelet sensitization by LDL";"RAF activation" lcl|NW_020311418.1_prot_XP_012261013.1_8006 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311313.1_prot_XP_012261887.1_2876 16 Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-72689 "SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits" lcl|NW_020311338.1_prot_XP_012263098.1_4553 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311419.1_prot_XP_012254043.1_8094 13 MetaCyc: PWY-7227;MetaCyc: PWY-7226;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7222;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7220;KEGG: 00230+1.17.4.1;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7184 "Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis I" lcl|NW_020311332.1_prot_XP_012268530.1_4104 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" lcl|NW_020311308.1_prot_XP_012253332.1_2223 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311958.1_prot_XP_025602454.1_12909 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311982.1_prot_XP_012258293.1_19291 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311977.1_prot_XP_012253880.1_17584 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" lcl|NW_020311995.1_prot_XP_012256760.1_21980 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311298.1_prot_XP_012269906.1_1214 3 Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154 "Smooth Muscle Contraction";"Purine metabolism";"Nitric oxide stimulates guanylate cyclase" lcl|NW_020311966.1_prot_XP_012252971.1_14533 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" lcl|NW_020311324.1_prot_XP_012269307.1_3577 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311939.1_prot_XP_012251672.1_11066 2 MetaCyc: PWY-6854;Reactome: R-HSA-3299685 "Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species" lcl|NW_020311475.1_prot_XP_020707126.1_9390 16 Reactome: R-HSA-6811558;Reactome: R-HSA-2219530;Reactome: R-HSA-389357;Reactome: R-HSA-1433557;Reactome: R-HSA-1660499;Reactome: R-HSA-1257604;Reactome: R-HSA-9009391;Reactome: R-HSA-1266695;Reactome: R-HSA-388841;Reactome: R-HSA-416476;Reactome: R-HSA-912631;Reactome: R-HSA-194840;Reactome: R-HSA-912526;Reactome: R-HSA-114604;Reactome: R-HSA-8853659;Reactome: R-HSA-512988 "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"CD28 dependent PI3K/Akt signaling";"Signaling by SCF-KIT";"Synthesis of PIPs at the plasma membrane";"PIP3 activates AKT signaling";"Extra-nuclear estrogen signaling";"Interleukin-7 signaling";"Costimulation by the CD28 family";"G alpha (q) signalling events";"Regulation of signaling by CBL";"Rho GTPase cycle";"Interleukin receptor SHC signaling";"GPVI-mediated activation cascade";"RET signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling" lcl|NW_020311915.1_prot_XP_020710082.1_10163 2 Reactome: R-HSA-975957;Reactome: R-HSA-9010553 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311418.1_prot_XP_012261010.1_8008 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311957.1_prot_XP_012263390.1_12865 8 Reactome: R-HSA-77387;Reactome: R-HSA-167590;Reactome: R-HSA-917977;Reactome: R-HSA-9636467;Reactome: R-HSA-182218;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-1222556 "Insulin receptor recycling";"Nef Mediated CD4 Down-regulation";"Transferrin endocytosis and recycling";"Blockage of phagosome acidification";"Nef Mediated CD8 Down-regulation";"Amino acids regulate mTORC1";"Ion channel transport";"ROS and RNS production in phagocytes" lcl|NW_020311978.1_prot_XP_012257703.1_18440 2 Reactome: R-HSA-1236974;Reactome: R-HSA-1799339 "ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311934.1_prot_XP_012255132.1_10807 2 MetaCyc: PWY-5386;KEGG: 00620+3.1.2.6 "Methylglyoxal degradation I";"Pyruvate metabolism" lcl|NW_020311313.1_prot_NP_001295467.1_3035 1 Reactome: R-HSA-419771 "Opsins" lcl|NW_020311309.1_prot_XP_020709041.1_2354 2 Reactome: R-HSA-6807878;Reactome: R-HSA-6811434 "COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311309.1_prot_XP_012259052.1_2389 5 Reactome: R-HSA-1169408;Reactome: R-HSA-936440;Reactome: R-HSA-6811555;Reactome: R-HSA-6804756;Reactome: R-HSA-5668599 "ISG15 antiviral mechanism";"Negative regulators of DDX58/IFIH1 signaling";"PI5P Regulates TP53 Acetylation";"Regulation of TP53 Activity through Phosphorylation";"RHO GTPases Activate NADPH Oxidases" lcl|NW_020311313.1_prot_XP_020709962.1_3031 1 Reactome: R-HSA-419771 "Opsins" lcl|NW_020311286.1_prot_XP_012256563.1_160 7 KEGG: 00220+3.5.3.1;KEGG: 00330+3.5.3.1;MetaCyc: PWY-46;MetaCyc: PWY-4984;MetaCyc: PWY-31;Reactome: R-HSA-70635;MetaCyc: PWY-6922 "Arginine biosynthesis";"Arginine and proline metabolism";"Putrescine biosynthesis III";"Urea cycle";"Canavanine degradation";"Urea cycle";"L-Ndelta-acetylornithine biosynthesis" lcl|NW_020311432.1_prot_XP_012268887.1_8495 6 Reactome: R-HSA-5099900;Reactome: R-HSA-76005;KEGG: 04070+2.7.11.13;Reactome: R-HSA-416993;Reactome: R-HSA-418597;Reactome: R-HSA-114516 "WNT5A-dependent internalization of FZD4";"Response to elevated platelet cytosolic Ca2+";"Phosphatidylinositol signaling system";"Trafficking of GluR2-containing AMPA receptors";"G alpha (z) signalling events";"Disinhibition of SNARE formation" lcl|NW_020311935.1_prot_XP_012266612.1_10919 6 Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-111367;Reactome: R-HSA-191859;Reactome: R-HSA-72165;Reactome: R-HSA-77588 "RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"SLBP independent Processing of Histone Pre-mRNAs";"snRNP Assembly";"mRNA Splicing - Minor Pathway";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" lcl|NW_020311984.1_prot_XP_020707618.1_20013 1 Reactome: R-HSA-400253 "Circadian Clock" lcl|NW_020311388.1_prot_XP_012262197.1_6950 2 Reactome: R-HSA-983168;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation" lcl|NW_020311334.1_prot_XP_020711341.1_4352 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311349.1_prot_XP_012262427.1_5160 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311343.1_prot_XP_020708753.1_4778 3 Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716 "Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" lcl|NW_020311992.1_prot_XP_012266425.1_21221 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311973.1_prot_XP_012258643.1_16563 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" lcl|NW_020311966.1_prot_XP_012256996.1_15092 8 Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-8943724;Reactome: R-HSA-1632852;Reactome: R-HSA-3371571;Reactome: R-HSA-9639288 "mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of PTEN gene transcription";"Macroautophagy";"HSF1-dependent transactivation";"Amino acids regulate mTORC1" lcl|NW_020311377.1_prot_XP_012260454.1_6595 3 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901;Reactome: R-HSA-8951664 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol";"Neddylation" lcl|NW_020311965.1_prot_XP_012259805.1_14198 11 Reactome: R-HSA-4043916;MetaCyc: PWY-7586;MetaCyc: PWY-5659;KEGG: 00520+5.3.1.8;MetaCyc: PWY-3861;MetaCyc: PWY-3881;Reactome: R-HSA-446205;KEGG: 00051+5.3.1.8;MetaCyc: PWY-882;MetaCyc: PWY-7456;MetaCyc: PWY-6992 "Defective MPI causes MPI-CDG (CDG-1b)";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"GDP-mannose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Mannitol degradation II";"Mannitol biosynthesis";"Synthesis of GDP-mannose";"Fructose and mannose metabolism";"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-(1,4)-mannan degradation";"1,5-anhydrofructose degradation" lcl|NW_020311333.1_prot_XP_012256094.1_4241 3 Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-674695 "RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events" lcl|NW_020311967.1_prot_XP_020707522.1_15331 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311962.1_prot_XP_012252112.1_13547 1 Reactome: R-HSA-191859 "snRNP Assembly" lcl|NW_020311968.1_prot_XP_012253081.1_15423 11 Reactome: R-HSA-400206;Reactome: R-HSA-1368082;Reactome: R-HSA-3214858;Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-1368108;Reactome: R-HSA-6804114;Reactome: R-HSA-2151201;Reactome: R-HSA-9018519;Reactome: R-HSA-2426168 "Regulation of lipid metabolism by PPARalpha";"RORA activates gene expression";"RMTs methylate histone arginines";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcriptional activation of mitochondrial biogenesis";"Estrogen-dependent gene expression";"Activation of gene expression by SREBF (SREBP)" lcl|NW_020311973.1_prot_XP_012258577.1_16347 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311472.1_prot_XP_020712446.1_9307 9 Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-6807505;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-167161 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"HIV Transcription Initiation" lcl|NW_020311994.1_prot_XP_012262166.1_21838 13 MetaCyc: PWY-7883;Reactome: R-HSA-2160916;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;MetaCyc: PWY-6902;Reactome: R-HSA-2022857;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-1660662;KEGG: 00513+3.2.1.52 "Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation";"Glycosphingolipid biosynthesis - ganglio series";"Chitin degradation III (Serratia)";"CS/DS degradation";"Chitin degradation II (Vibrio)";"Keratan sulfate degradation";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid metabolism";"Various types of N-glycan biosynthesis" lcl|NW_020311962.1_prot_XP_012251920.1_13818 4 Reactome: R-HSA-75955;Reactome: R-HSA-8866654;Reactome: R-HSA-674695;Reactome: R-HSA-112382 "RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex" lcl|NW_020311993.1_prot_XP_012263187.1_21344 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311962.1_prot_XP_012251931.1_13816 12 Reactome: R-HSA-9013700;Reactome: R-HSA-205043;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-193692;Reactome: R-HSA-3928665;Reactome: R-HSA-1251985;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-9017802;Reactome: R-HSA-977225 "NOTCH4 Activation and Transmission of Signal to the Nucleus";"NRIF signals cell death from the nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulated proteolysis of p75NTR";"EPH-ephrin mediated repulsion of cells";"Nuclear signaling by ERBB4";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Amyloid fiber formation" lcl|NW_020311980.1_prot_XP_020709760.1_18869 2 MetaCyc: PWY-6558;Reactome: R-HSA-2022928 "Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis" lcl|NW_020311973.1_prot_XP_012258821.1_16442 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" lcl|NW_020311962.1_prot_XP_012251865.1_13838 3 KEGG: 00643+3.7.1.2;Reactome: R-HSA-8963684;KEGG: 00350+3.7.1.2 "Styrene degradation";"Tyrosine catabolism";"Tyrosine metabolism" lcl|NW_020311349.1_prot_XP_012251118.1_5262 6 Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68867 "Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Unwinding of DNA";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex" lcl|NW_020311298.1_prot_XP_012250561.1_1131 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311984.1_prot_XP_012267719.1_20112 8 Reactome: R-HSA-113501;Reactome: R-HSA-69183;Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-174430;Reactome: R-HSA-68952;Reactome: R-HSA-69091;Reactome: R-HSA-69166 "Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Processive synthesis on the lagging strand";"Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand synthesis initiation";"DNA replication initiation";"Polymerase switching";"Removal of the Flap Intermediate" lcl|NW_020311994.1_prot_XP_012267544.1_21690 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" lcl|NW_020311346.1_prot_XP_020710301.1_4986 29 Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-77075;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-72086;Reactome: R-HSA-76042;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-6781827;Reactome: R-HSA-73779;Reactome: R-HSA-167246;Reactome: R-HSA-6796648;Reactome: R-HSA-73863;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-5696400 "HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Capping";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Tat-mediated elongation of the HIV-1 transcript";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER" lcl|NW_020311338.1_prot_XP_012263065.1_4512 1 Reactome: R-HSA-499943 "Interconversion of nucleotide di- and triphosphates" lcl|NW_020311982.1_prot_XP_012258439.1_19270 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311956.1_prot_XP_020707557.1_12582 4 Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-5625970 "COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Kinesins";"RHO GTPases activate KTN1" lcl|NW_020311298.1_prot_XP_012250513.1_1137 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311339.1_prot_XP_012252116.1_4622 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" lcl|NW_020311982.1_prot_XP_012258471.1_19228 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311951.1_prot_XP_012259198.1_12227 3 Reactome: R-HSA-6807505;Reactome: R-HSA-749476;Reactome: R-HSA-76071 "RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" lcl|NW_020311298.1_prot_XP_012250588.1_1223 3 Reactome: R-HSA-202427;Reactome: R-HSA-6798695;Reactome: R-HSA-6807004 "Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation";"Negative regulation of MET activity" lcl|NW_020311974.1_prot_XP_012260298.1_16892 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311292.1_prot_XP_020710267.1_693 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-112308 "NCAM1 interactions";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening" lcl|NW_020311992.1_prot_XP_012266537.1_21017 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311985.1_prot_XP_012265260.1_20241 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311975.1_prot_XP_012251319.1_16942 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311386.1_prot_XP_012268141.1_6926 7 MetaCyc: PWY-6610;KEGG: 00230+2.4.2.7;Reactome: R-HSA-6798695;Reactome: R-HSA-74217;MetaCyc: PWY-7807;MetaCyc: PWY-6605;MetaCyc: PWY-7805 "Adenine salvage";"Purine metabolism";"Neutrophil degranulation";"Purine salvage";"Glyphosate degradation III";"Adenine and adenosine salvage II";"(aminomethyl)phosphonate degradation" lcl|NW_020311977.1_prot_XP_012263767.1_17678 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311619.1_prot_XP_012260701.1_10075 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311961.1_prot_XP_012262616.1_13245 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311981.1_prot_XP_012257477.1_19038 11 Reactome: R-HSA-205043;Reactome: R-HSA-2894862;Reactome: R-HSA-9013700;Reactome: R-HSA-3928665;Reactome: R-HSA-193692;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-9017802;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096 "NRIF signals cell death from the nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"EPH-ephrin mediated repulsion of cells";"Regulated proteolysis of p75NTR";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"Noncanonical activation of NOTCH3";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus" lcl|NW_020311339.1_prot_XP_012252316.1_4606 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311298.1_prot_XP_012250584.1_1221 3 Reactome: R-HSA-6807004;Reactome: R-HSA-202427;Reactome: R-HSA-6798695 "Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation" lcl|NW_020311961.1_prot_XP_020710229.1_13520 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311961.1_prot_XP_012262547.1_13512 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311312.1_prot_XP_012266950.1_2782 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311401.1_prot_XP_020707787.1_7506 4 Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-8943724;Reactome: R-HSA-73762 "HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation" lcl|NW_020311346.1_prot_XP_020710304.1_4954 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311964.1_prot_XP_012261974.1_14023 6 Reactome: R-HSA-5545483;Reactome: R-HSA-5358565;Reactome: R-HSA-6796648;Reactome: R-HSA-5632987;Reactome: R-HSA-5358606;Reactome: R-HSA-912446 "Defective Mismatch Repair Associated With MLH1";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With PMS2";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Meiotic recombination" lcl|NW_020311382.1_prot_XP_012268031.1_6871 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311971.1_prot_XP_012260866.1_15891 3 Reactome: R-HSA-5656169;Reactome: R-HSA-110320;Reactome: R-HSA-5685942 "Termination of translesion DNA synthesis";"Translesion Synthesis by POLH";"HDR through Homologous Recombination (HRR)" lcl|NW_020311373.1_prot_XP_020710374.1_6409 1 Reactome: R-HSA-111957 "Cam-PDE 1 activation" lcl|NW_020311984.1_prot_XP_020707620.1_20015 1 Reactome: R-HSA-400253 "Circadian Clock" lcl|NW_020311346.1_prot_XP_020710325.1_4993 2 Reactome: R-HSA-419812;Reactome: R-HSA-418555 "Calcitonin-like ligand receptors";"G alpha (s) signalling events" lcl|NW_020311313.1_prot_XP_020709886.1_2898 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311977.1_prot_XP_012264102.1_17760 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311966.1_prot_XP_012256311.1_14866 25 Reactome: R-HSA-8941284;Reactome: R-HSA-9616222;Reactome: R-HSA-8939242;Reactome: R-HSA-8949275;Reactome: R-HSA-8939246;Reactome: R-HSA-8934593;Reactome: R-HSA-8936459;Reactome: R-HSA-8951936;Reactome: R-HSA-8939247;Reactome: R-HSA-8941858;Reactome: R-HSA-8935964;Reactome: R-HSA-8939236;Reactome: R-HSA-8939245;Reactome: R-HSA-9018519;Reactome: R-HSA-8940973;Reactome: R-HSA-8951911;Reactome: R-HSA-8931987;Reactome: R-HSA-8939902;Reactome: R-HSA-8941332;Reactome: R-HSA-8941326;Reactome: R-HSA-8941333;Reactome: R-HSA-8939256;Reactome: R-HSA-8939243;Reactome: R-HSA-8877330;Reactome: R-HSA-8878166 "RUNX2 regulates chondrocyte maturation";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX3 regulates p14-ARF";"RUNX1 regulates transcription of genes involved in interleukin signaling";"Regulation of RUNX3 expression and activity";"RUNX1 regulates expression of components of tight junctions";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 regulates transcription of genes involved in BCR signaling";"Estrogen-dependent gene expression";"RUNX2 regulates osteoblast differentiation";"RUNX3 regulates RUNX1-mediated transcription";"RUNX1 regulates estrogen receptor mediated transcription";"Regulation of RUNX2 expression and activity";"RUNX2 regulates genes involved in cell migration";"RUNX2 regulates bone development";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates transcription of genes involved in WNT signaling";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"Transcriptional regulation by RUNX2" lcl|NW_020311353.1_prot_XP_020708033.1_5404 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311418.1_prot_XP_012261046.1_7994 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311408.1_prot_XP_012262141.1_7810 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311502.1_prot_XP_012251079.1_9588 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311317.1_prot_XP_012254429.1_3216 3 Reactome: R-HSA-2299718;Reactome: R-HSA-6804760;Reactome: R-HSA-3214841 "Condensation of Prophase Chromosomes";"Regulation of TP53 Activity through Methylation";"PKMTs methylate histone lysines" lcl|NW_020311311.1_prot_XP_012250905.1_2459 6 Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-427359;Reactome: R-HSA-73772 "NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"SIRT1 negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape" lcl|NW_020311292.1_prot_XP_012262858.1_695 4 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-419037 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"NCAM1 interactions" lcl|NW_020311965.1_prot_XP_012259711.1_14329 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311983.1_prot_XP_012255526.1_19804 3 Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311559.1_prot_XP_020712364.1_10042 1 Reactome: R-HSA-611105 "Respiratory electron transport" lcl|NW_020311298.1_prot_XP_012269902.1_1235 5 KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00561+3.2.1.22 "Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Stachyose degradation";"Galactose metabolism";"Glycerolipid metabolism" lcl|NW_020311992.1_prot_XP_012266289.1_21021 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311944.1_prot_XP_012254167.1_11800 1 Reactome: R-HSA-5617833 "Cilium Assembly" lcl|NW_020311984.1_prot_XP_012254503.1_19955 3 Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434 "Kinesins";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311288.1_prot_XP_012267089.1_336 7 Reactome: R-HSA-5625886;Reactome: R-HSA-9029569;Reactome: R-HSA-8943724;Reactome: R-HSA-983231;Reactome: R-HSA-3214815;Reactome: R-HSA-9018519;Reactome: R-HSA-3214842 "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of PTEN gene transcription";"Factors involved in megakaryocyte development and platelet production";"HDACs deacetylate histones";"Estrogen-dependent gene expression";"HDMs demethylate histones" lcl|NW_020311958.1_prot_XP_012255504.1_12956 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" lcl|NW_020311321.1_prot_XP_012263248.1_3432 2 Reactome: R-HSA-3928665;Reactome: R-HSA-2682334 "EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling" lcl|NW_020311966.1_prot_XP_012256985.1_14733 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311961.1_prot_XP_020710227.1_13518 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311974.1_prot_XP_012260157.2_16765 25 Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-190861;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-3371497;Reactome: R-HSA-5617833;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-380270;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-437239;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-380320;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399 "COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Gap junction assembly";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Cilium Assembly";"Kinesins";"Resolution of Sister Chromatid Cohesion";"Recruitment of mitotic centrosome proteins and complexes";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Recycling pathway of L1";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"HCMV Early Events";"Recruitment of NuMA to mitotic centrosomes";"Separation of Sister Chromatids";"Aggrephagy" lcl|NW_020311955.1_prot_XP_012265459.1_12348 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311936.1_prot_XP_025602327.1_10992 5 Reactome: R-HSA-2559580;Reactome: R-HSA-2871796;Reactome: R-HSA-450321;Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24 "Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"mTOR signaling pathway" lcl|NW_020311974.1_prot_XP_012259889.1_16917 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" lcl|NW_020311932.1_prot_XP_012252927.1_10703 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311980.1_prot_XP_020709787.1_18849 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311393.1_prot_XP_012265746.1_7151 7 MetaCyc: PWY-5686;MetaCyc: PWY-7790;MetaCyc: PWY-7791;KEGG: 00240+3.5.2.3;MetaCyc: PWY-5698;MetaCyc: PWY-5697;KEGG: 00230+3.5.2.5 "UMP biosynthesis I";"UMP biosynthesis II";"UMP biosynthesis III";"Pyrimidine metabolism";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Allantoin degradation to ureidoglycolate I (urea producing)";"Purine metabolism" lcl|NW_020311974.1_prot_XP_012259827.1_16692 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311513.1_prot_XP_020711386.1_9886 6 MetaCyc: PWY-7920;Reactome: R-HSA-975578;MetaCyc: PWY-7426;Reactome: R-HSA-4793952;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143 "Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis" lcl|NW_020311356.1_prot_XP_020711754.1_5569 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311419.1_prot_XP_012254031.1_8111 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311975.1_prot_XP_025602713.1_16973 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311979.1_prot_XP_012259732.1_18548 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" lcl|NW_020311962.1_prot_XP_012252155.1_13737 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" lcl|NW_020311332.1_prot_XP_012256969.1_4163 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311987.1_prot_XP_012269163.1_20371 13 Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9010553 "Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311984.1_prot_XP_020707576.1_20001 5 Reactome: R-HSA-6798695;Reactome: R-HSA-197264;Reactome: R-HSA-1368108;MetaCyc: PWY-5381;KEGG: 00760+6.3.4.21 "Neutrophil degranulation";"Nicotinamide salvaging";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism" lcl|NW_020311988.1_prot_XP_012269134.1_20587 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311995.1_prot_XP_012256816.1_21926 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311373.1_prot_XP_012266689.1_6448 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311286.1_prot_XP_012256887.1_148 4 Reactome: R-HSA-1799339;Reactome: R-HSA-381771;Reactome: R-HSA-422085;Reactome: R-HSA-400511 "SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)" lcl|NW_020311982.1_prot_XP_012258130.1_19344 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" lcl|NW_020311991.1_prot_XP_012269740.1_20922 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311286.1_prot_XP_012257263.1_111 9 Reactome: R-HSA-4420332;Reactome: R-HSA-3560801;Reactome: R-HSA-3656253;Reactome: R-HSA-975634;Reactome: R-HSA-2022928;Reactome: R-HSA-1971475;Reactome: R-HSA-3560783;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096 "Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective B3GAT3 causes JDSSDHD";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Retinoid metabolism and transport";"HS-GAG biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B4GALT7 causes EDS, progeroid type";"Defective EXT2 causes exostoses 2";"HS-GAG degradation" lcl|NW_020311299.1_prot_XP_012263233.1_1444 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" lcl|NW_020311966.1_prot_XP_012252975.1_14534 2 KEGG: 00760+2.3.1.286;Reactome: R-HSA-2151201 "Nicotinate and nicotinamide metabolism";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311981.1_prot_XP_012257525.1_19019 4 Reactome: R-HSA-2173789;Reactome: R-HSA-3304356;Reactome: R-HSA-3656532;Reactome: R-HSA-2173788 "TGF-beta receptor signaling activates SMADs";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"Downregulation of TGF-beta receptor signaling" lcl|NW_020311401.1_prot_XP_020707786.1_7505 4 Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-8943724 "HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"Regulation of PTEN gene transcription" lcl|NW_020311978.1_prot_XP_012257950.1_18366 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" lcl|NW_020311432.1_prot_XP_012268943.1_8321 1 Reactome: R-HSA-71403 "Citric acid cycle (TCA cycle)" lcl|NW_020311957.1_prot_XP_012262131.1_12719 3 Reactome: R-HSA-159740;MetaCyc: PWY-7999;KEGG: 00130+4.1.1.90 "Gamma-carboxylation of protein precursors";"Vitamin K-epoxide cycle";"Ubiquinone and other terpenoid-quinone biosynthesis" lcl|NW_020311987.1_prot_XP_020712074.1_20419 3 MetaCyc: PWY-5963;KEGG: 00790+2.8.1.9;Reactome: R-HSA-947581 "Thio-molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis" lcl|NW_020311312.1_prot_XP_020711706.1_2763 5 Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-162588;Reactome: R-HSA-917729;Reactome: R-HSA-9610379 "Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events" lcl|NW_020311977.1_prot_XP_020710732.1_17871 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311408.1_prot_XP_020710023.1_7796 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311408.1_prot_XP_020710019.1_7804 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311964.1_prot_XP_025602537.1_13907 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311971.1_prot_XP_012263538.1_16087 12 Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids" lcl|NW_020311983.1_prot_XP_012255674.1_19653 3 Reactome: R-HSA-264870;Reactome: R-HSA-6798695;Reactome: R-HSA-6794361 "Caspase-mediated cleavage of cytoskeletal proteins";"Neutrophil degranulation";"Neurexins and neuroligins" lcl|NW_020311310.1_prot_XP_012255712.1_2411 3 Reactome: R-HSA-5423646;Reactome: R-HSA-2142691;MetaCyc: PWY-7533 "Aflatoxin activation and detoxification";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis" lcl|NW_020311292.1_prot_XP_012252549.1_644 2 Reactome: R-HSA-9033241;Reactome: R-HSA-8866654 "Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins" lcl|NW_020311286.1_prot_XP_020708389.1_240 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311419.1_prot_XP_012254038.1_8115 7 Reactome: R-HSA-165159;Reactome: R-HSA-8943724;Reactome: R-HSA-380972;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-1632852 "mTOR signalling";"Regulation of PTEN gene transcription";"Energy dependent regulation of mTOR by LKB1-AMPK";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"Macroautophagy" lcl|NW_020311961.1_prot_XP_012262650.1_13463 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311937.1_prot_XP_020706895.1_11025 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311994.1_prot_XP_012267456.1_21796 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311389.1_prot_XP_025601958.1_6999 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" lcl|NW_020311982.1_prot_XP_025602859.1_19336 2 Reactome: R-HSA-3769402;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex" lcl|NW_020311365.1_prot_XP_020712496.1_6021 2 Reactome: R-HSA-5205685;Reactome: R-HSA-983231 "Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production" lcl|NW_020311300.1_prot_XP_012253235.1_1535 1 Reactome: R-HSA-6811436 "COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311959.1_prot_XP_012254239.1_13203 1 Reactome: R-HSA-197264 "Nicotinamide salvaging" lcl|NW_020311396.1_prot_XP_025601983.1_7271 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311317.1_prot_XP_012250956.1_3235 5 Reactome: R-HSA-2022857;KEGG: 00531+3.1.6.14;Reactome: R-HSA-2206305;Reactome: R-HSA-6798695;Reactome: R-HSA-432720 "Keratan sulfate degradation";"Glycosaminoglycan degradation";"MPS IIID - Sanfilippo syndrome D";"Neutrophil degranulation";"Lysosome Vesicle Biogenesis" lcl|NW_020311974.1_prot_XP_012260295.1_16889 1 Reactome: R-HSA-1614558 "Degradation of cysteine and homocysteine" lcl|NW_020311994.1_prot_XP_025602990.1_21835 13 Reactome: R-HSA-1660662;KEGG: 00513+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;MetaCyc: PWY-6902;Reactome: R-HSA-2022857;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7883;Reactome: R-HSA-2160916 "Glycosphingolipid metabolism";"Various types of N-glycan biosynthesis";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Chitin degradation II (Vibrio)";"Keratan sulfate degradation";"Chitin degradation III (Serratia)";"CS/DS degradation";"Glycosphingolipid biosynthesis - ganglio series";"Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation" lcl|NW_020311381.1_prot_XP_012252342.1_6841 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311373.1_prot_XP_012266722.1_6474 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311992.1_prot_XP_012266276.1_21093 17 Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-6790901;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"rRNA modification in the nucleus and cytosol";"Viral mRNA Translation";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination" lcl|NW_020311432.1_prot_XP_012268716.1_8470 10 Reactome: R-HSA-76042;Reactome: R-HSA-9018519;Reactome: R-HSA-73779;Reactome: R-HSA-167161;Reactome: R-HSA-6807505;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-674695;Reactome: R-HSA-73776 "RNA Polymerase II Transcription Initiation And Promoter Clearance";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HIV Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape" lcl|NW_020311317.1_prot_XP_012250745.1_3240 13 Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72689 "Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits" lcl|NW_020311377.1_prot_XP_020709520.1_6609 1 Reactome: R-HSA-5693607 "Processing of DNA double-strand break ends" lcl|NW_020311289.1_prot_XP_012253885.1_378 2 Reactome: R-HSA-6804758;Reactome: R-HSA-3214847 "Regulation of TP53 Activity through Acetylation";"HATs acetylate histones" lcl|NW_020311327.1_prot_XP_012252872.1_3800 9 MetaCyc: PWY-6142;MetaCyc: PWY-5789;MetaCyc: PWY-5743;MetaCyc: PWY-7115;MetaCyc: PWY-7117;MetaCyc: PWY-241;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5744;Reactome: R-HSA-1475029 "Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Nitrogen metabolism";"Glyoxylate assimilation";"Reversible hydration of carbon dioxide" lcl|NW_020311432.1_prot_XP_012268913.1_8345 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311934.1_prot_XP_020707746.1_10820 2 KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20 "Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis" lcl|NW_020311407.1_prot_XP_012255244.1_7782 2 Reactome: R-HSA-983168;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation" lcl|NW_020311353.1_prot_XP_020707979.1_5390 1 Reactome: R-HSA-880009 "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" lcl|NW_020311513.1_prot_XP_020711470.1_9852 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311984.1_prot_XP_012267711.1_20139 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" lcl|NW_020311983.1_prot_XP_012255659.1_19755 1 Reactome: R-HSA-71403 "Citric acid cycle (TCA cycle)" lcl|NW_020311977.1_prot_XP_012253866.1_17558 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311391.1_prot_XP_012251529.1_7049 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311969.1_prot_XP_012264844.1_15526 4 Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-8866654 "RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"E3 ubiquitin ligases ubiquitinate target proteins" lcl|NW_020311361.1_prot_XP_020709841.1_5786 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311966.1_prot_XP_020708087.1_14957 7 Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025 "Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311971.1_prot_XP_020710493.1_16032 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311953.1_prot_XP_012260604.1_12235 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311311.1_prot_XP_020706388.1_2468 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311971.1_prot_XP_012263505.1_16055 14 Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-5685942;Reactome: R-HSA-5696400;Reactome: R-HSA-5656121;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-5655862;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-110320;Reactome: R-HSA-5696397;Reactome: R-HSA-69091;Reactome: R-HSA-110314 "Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"HDR through Homologous Recombination (HRR)";"Dual Incision in GG-NER";"Translesion synthesis by POLI";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Translesion synthesis by POLK";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion Synthesis by POLH";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Polymerase switching";"Recognition of DNA damage by PCNA-containing replication complex" lcl|NW_020311992.1_prot_XP_020711549.1_21141 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311946.1_prot_XP_020712233.1_11917 1 Reactome: R-HSA-197264 "Nicotinamide salvaging" lcl|NW_020311957.1_prot_XP_012263406.1_12776 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311933.1_prot_XP_012258714.1_10747 26 Reactome: R-HSA-174414;Reactome: R-HSA-5696397;Reactome: R-HSA-110320;Reactome: R-HSA-1362277;Reactome: R-HSA-69166;Reactome: R-HSA-4615885;Reactome: R-HSA-6804114;Reactome: R-HSA-5696400;Reactome: R-HSA-5358565;Reactome: R-HSA-174417;Reactome: R-HSA-110312;Reactome: R-HSA-110314;Reactome: R-HSA-5358606;Reactome: R-HSA-69091;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-174437;Reactome: R-HSA-5655862;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-69183;Reactome: R-HSA-5656121;Reactome: R-HSA-69205;Reactome: R-HSA-8866654;Reactome: R-HSA-174411;Reactome: R-HSA-5685942 "Processive synthesis on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion Synthesis by POLH";"Transcription of E2F targets under negative control by DREAM complex";"Removal of the Flap Intermediate";"SUMOylation of DNA replication proteins";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Dual Incision in GG-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Telomere C-strand (Lagging Strand) Synthesis";"Translesion synthesis by REV1";"Recognition of DNA damage by PCNA-containing replication complex";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Polymerase switching";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Removal of the Flap Intermediate from the C-strand";"Translesion synthesis by POLK";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Processive synthesis on the lagging strand";"Translesion synthesis by POLI";"G1/S-Specific Transcription";"E3 ubiquitin ligases ubiquitinate target proteins";"Polymerase switching on the C-strand of the telomere";"HDR through Homologous Recombination (HRR)" lcl|NW_020311619.1_prot_XP_012260696.1_10082 23 Reactome: R-HSA-500657;Reactome: R-HSA-418555;Reactome: R-HSA-381676;Reactome: R-HSA-418592;Reactome: R-HSA-202040;Reactome: R-HSA-418597;Reactome: R-HSA-428930;Reactome: R-HSA-6814122;Reactome: R-HSA-416482;Reactome: R-HSA-456926;Reactome: R-HSA-432040;Reactome: R-HSA-4086398;Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-8964315;Reactome: R-HSA-392451;Reactome: R-HSA-392851;Reactome: R-HSA-418217;Reactome: R-HSA-420092;Reactome: R-HSA-400042;Reactome: R-HSA-392170;Reactome: R-HSA-9009391;Reactome: R-HSA-8964616 "Presynaptic function of Kainate receptors";"G alpha (s) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"ADP signalling through P2Y purinoceptor 1";"G-protein activation";"G alpha (z) signalling events";"Thromboxane signalling through TP receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (12/13) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"Vasopressin regulates renal water homeostasis via Aquaporins";"Ca2+ pathway";"G alpha (i) signalling events";"G alpha (q) signalling events";"G beta:gamma signalling through BTK";"G beta:gamma signalling through PI3Kgamma";"Prostacyclin signalling through prostacyclin receptor";"G beta:gamma signalling through PLC beta";"Glucagon-type ligand receptors";"Adrenaline,noradrenaline inhibits insulin secretion";"ADP signalling through P2Y purinoceptor 12";"Extra-nuclear estrogen signaling";"G beta:gamma signalling through CDC42" lcl|NW_020311312.1_prot_XP_012266807.1_2672 5 MetaCyc: PWY-8043;KEGG: 00270+6.3.2.3;Reactome: R-HSA-5579006;Reactome: R-HSA-174403;KEGG: 00480+6.3.2.3 "Ophthalmate biosynthesis";"Cysteine and methionine metabolism";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Glutathione synthesis and recycling";"Glutathione metabolism" lcl|NW_020311287.1_prot_XP_012268062.1_292 3 KEGG: 00330+1.14.11.2;MetaCyc: PWY-7894;Reactome: R-HSA-1650814 "Arginine and proline metabolism";"Procollagen hydroxylation and glycosylation";"Collagen biosynthesis and modifying enzymes" lcl|NW_020311401.1_prot_XP_012255267.1_7417 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311979.1_prot_XP_012259379.1_18549 16 Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339 "Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311959.1_prot_XP_025602469.1_13065 2 Reactome: R-HSA-72165;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" lcl|NW_020311333.1_prot_XP_012256135.1_4218 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311401.1_prot_XP_020707760.1_7581 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311325.1_prot_XP_012269663.1_3659 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311511.1_prot_XP_012250964.1_9655 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311347.1_prot_XP_012266211.1_5076 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311974.1_prot_XP_012260294.1_16888 1 Reactome: R-HSA-1614558 "Degradation of cysteine and homocysteine" lcl|NW_020311359.1_prot_XP_012251872.1_5693 33 Reactome: R-HSA-69231;Reactome: R-HSA-112382;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-167158;Reactome: R-HSA-6782210;Reactome: R-HSA-167160;Reactome: R-HSA-8939236;Reactome: R-HSA-167200;Reactome: R-HSA-76042;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-69656;Reactome: R-HSA-6796648;Reactome: R-HSA-73863;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-77075;Reactome: R-HSA-167172;Reactome: R-HSA-73772;Reactome: R-HSA-167152;Reactome: R-HSA-167161;Reactome: R-HSA-6781827;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-75955;Reactome: R-HSA-72086;Reactome: R-HSA-167162;Reactome: R-HSA-69202;Reactome: R-HSA-73776;Reactome: R-HSA-69273 "Cyclin D associated events in G1";"Formation of RNA Pol II elongation complex";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"Cyclin A:Cdk2-associated events at S phase entry";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcription of the HIV genome";"RNA Polymerase I Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Elongation";"mRNA Capping";"RNA Polymerase II HIV Promoter Escape";"Cyclin E associated events during G1/S transition";"RNA Polymerase II Promoter Escape";"Cyclin A/B1/B2 associated events during G2/M transition" lcl|NW_020311318.1_prot_XP_020707255.1_3308 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" lcl|NW_020311526.1_prot_XP_025602199.1_9939 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311305.1_prot_XP_025602889.1_2042 3 Reactome: R-HSA-8939243;Reactome: R-HSA-2559580;Reactome: R-HSA-8943724 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Oxidative Stress Induced Senescence";"Regulation of PTEN gene transcription" lcl|NW_020311970.1_prot_XP_012267438.1_15811 2 Reactome: R-HSA-1237112;Reactome: R-HSA-8950505 "Methionine salvage pathway";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" lcl|NW_020311315.1_prot_XP_012265242.1_3125 2 Reactome: R-HSA-1660662;Reactome: R-HSA-1663150 "Glycosphingolipid metabolism";"The activation of arylsulfatases" lcl|NW_020311987.1_prot_XP_012269208.1_20356 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311298.1_prot_XP_020706236.1_1146 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311954.1_prot_XP_012268169.1_12334 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" lcl|NW_020311353.1_prot_XP_020708035.1_5403 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311979.1_prot_XP_020709164.1_18515 1 Reactome: R-HSA-446199 "Synthesis of Dolichyl-phosphate" lcl|NW_020311965.1_prot_XP_012260316.1_14059 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311953.1_prot_XP_020709485.1_12246 6 Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817 "Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)" lcl|NW_020311978.1_prot_XP_020708563.1_18066 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311441.1_prot_XP_025602112.1_8887 3 KEGG: 00860+1.3.3.4;MetaCyc: PWY-7159;Reactome: R-HSA-189451 "Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis" lcl|NW_020311436.1_prot_XP_020708705.1_8764 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311995.1_prot_XP_012257272.1_22075 14 Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-167158;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-6796648 "RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes" lcl|NW_020311513.1_prot_XP_012266192.1_9884 6 MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952 "Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)" lcl|NW_020311994.1_prot_XP_012267556.1_21805 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311306.1_prot_XP_012265929.1_2150 1 KEGG: 00010+5.1.3.15 "Glycolysis / Gluconeogenesis" lcl|NW_020311992.1_prot_XP_012266557.1_21020 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311327.1_prot_XP_012263474.1_3885 2 Reactome: R-HSA-8866423;Reactome: R-HSA-8963888 "VLDL assembly";"Chylomicron assembly" lcl|NW_020311391.1_prot_XP_012256739.1_7025 4 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing" lcl|NW_020311958.1_prot_XP_020708064.1_12988 13 Reactome: R-HSA-114508;Reactome: R-HSA-1489509;Reactome: R-HSA-2871809;Reactome: R-HSA-5578775;Reactome: R-HSA-422356;Reactome: R-HSA-2029485;Reactome: R-HSA-5607763;Reactome: R-HSA-139853;Reactome: R-HSA-381676;Reactome: R-HSA-4086398;Reactome: R-HSA-983695;Reactome: R-HSA-5218921;Reactome: R-HSA-112043 "Effects of PIP2 hydrolysis";"DAG and IP3 signaling";"FCERI mediated Ca+2 mobilization";"Ion homeostasis";"Regulation of insulin secretion";"Role of phospholipids in phagocytosis";"CLEC7A (Dectin-1) induces NFAT activation";"Elevation of cytosolic Ca2+ levels";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Ca2+ pathway";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"VEGFR2 mediated cell proliferation";"PLC beta mediated events" lcl|NW_020311327.1_prot_XP_012263301.1_3864 18 MetaCyc: PWY-7226;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7224;MetaCyc: PWY-7222;MetaCyc: PWY-7197;MetaCyc: PWY-7220;KEGG: 00230+2.7.4.6;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7227;MetaCyc: PWY-7198;MetaCyc: PWY-7176;MetaCyc: PWY-7210;MetaCyc: PWY-7187;MetaCyc: PWY-7205;Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7221;MetaCyc: PWY-7184 "Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Purine deoxyribonucleosides salvage";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"CMP phosphorylation";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I" lcl|NW_020311975.1_prot_XP_020706538.1_17007 14 Reactome: R-HSA-1483166;MetaCyc: PWY-7782;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5667;MetaCyc: PWY-7587;MetaCyc: PWY-6453;MetaCyc: PWY-7417;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-7589;MetaCyc: PWY-8053;MetaCyc: PWY-8055 "Synthesis of PA";"Plasmalogen biosynthesis";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Palmitoleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis" lcl|NW_020311967.1_prot_XP_012254365.1_15293 1 Reactome: R-HSA-606279 "Deposition of new CENPA-containing nucleosomes at the centromere" lcl|NW_020311286.1_prot_XP_012257178.1_139 6 KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508 "Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis" lcl|NW_020311343.1_prot_XP_020708745.1_4786 3 Reactome: R-HSA-983168;Reactome: R-HSA-6798695;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"Protein ubiquitination" lcl|NW_020311401.1_prot_XP_012254897.1_7539 22 Reactome: R-HSA-5358747;Reactome: R-HSA-5467348;Reactome: R-HSA-195253;Reactome: R-HSA-5358751;Reactome: R-HSA-196299;Reactome: R-HSA-389513;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5675221;Reactome: R-HSA-4641262;Reactome: R-HSA-5358749;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5339716;Reactome: R-HSA-5467340;Reactome: R-HSA-5663220;Reactome: R-HSA-5467337;Reactome: R-HSA-2467813;Reactome: R-HSA-5673000;Reactome: R-HSA-432142;Reactome: R-HSA-6811558;Reactome: R-HSA-5358752 "S33 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"CTLA4 inhibitory signaling";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Negative regulation of MAPK pathway";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S37 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex";"RHO GTPases Activate Formins";"APC truncation mutants have impaired AXIN binding";"Separation of Sister Chromatids";"RAF activation";"Platelet sensitization by LDL";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated" lcl|NW_020311310.1_prot_XP_020707969.1_2438 5 Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902 "Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)" lcl|NW_020311475.1_prot_XP_020707127.1_9391 16 Reactome: R-HSA-9009391;Reactome: R-HSA-388841;Reactome: R-HSA-1266695;Reactome: R-HSA-416476;Reactome: R-HSA-512988;Reactome: R-HSA-912526;Reactome: R-HSA-912631;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-8853659;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558;Reactome: R-HSA-389357;Reactome: R-HSA-1660499;Reactome: R-HSA-1433557;Reactome: R-HSA-1257604 "Extra-nuclear estrogen signaling";"Costimulation by the CD28 family";"Interleukin-7 signaling";"G alpha (q) signalling events";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Interleukin receptor SHC signaling";"Regulation of signaling by CBL";"Rho GTPase cycle";"GPVI-mediated activation cascade";"RET signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"CD28 dependent PI3K/Akt signaling";"Synthesis of PIPs at the plasma membrane";"Signaling by SCF-KIT";"PIP3 activates AKT signaling" lcl|NW_020311356.1_prot_XP_012267112.1_5539 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311417.1_prot_XP_025602027.1_7953 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" lcl|NW_020311311.1_prot_XP_020706344.1_2449 10 MetaCyc: PWY-4041;MetaCyc: PWY-6842;MetaCyc: PWY-8001;MetaCyc: PWY-7112;MetaCyc: PWY-5826;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-4061;KEGG: 00460+2.3.2.2;MetaCyc: PWY-7559 "Gamma-glutamyl cycle";"Glutathione-mediated detoxification II";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"4-hydroxy-2-nonenal detoxification";"Hypoglycin biosynthesis";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"Glutathione-mediated detoxification I";"Cyanoamino acid metabolism";"Glutathione degradation (DUG pathway" lcl|NW_020311974.1_prot_XP_012260190.1_16715 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311357.1_prot_XP_012259676.1_5625 4 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-6807505 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"RNA polymerase II transcribes snRNA genes" lcl|NW_020311321.1_prot_XP_012263207.1_3408 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311299.1_prot_XP_020711975.1_1403 14 MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-8041;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-7036;KEGG: 00062+2.3.1.199 "(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation" lcl|NW_020311948.1_prot_XP_020707195.1_12024 7 MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-3108214;Reactome: R-HSA-5693565 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"SUMOylation of DNA damage response and repair proteins";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" lcl|NW_020311315.1_prot_XP_012265241.1_3124 2 Reactome: R-HSA-1660662;Reactome: R-HSA-1663150 "Glycosphingolipid metabolism";"The activation of arylsulfatases" lcl|NW_020311966.1_prot_XP_012251731.1_14582 5 KEGG: 00250+1.2.1.88;Reactome: R-HSA-389661;MetaCyc: PWY-6853;Reactome: R-HSA-70688;KEGG: 00330+1.2.1.88 "Alanine, aspartate and glutamate metabolism";"Glyoxylate metabolism and glycine degradation";"Ethylene biosynthesis II (microbes)";"Proline catabolism";"Arginine and proline metabolism" lcl|NW_020311965.1_prot_XP_012260369.1_14057 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311959.1_prot_XP_012262289.1_13089 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311959.1_prot_XP_012254234.1_13210 1 Reactome: R-HSA-525793 "Myogenesis" lcl|NW_020311966.1_prot_XP_012251728.1_14592 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311302.1_prot_XP_012264462.1_1698 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311946.1_prot_XP_012268854.1_11852 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311966.1_prot_XP_012251729.1_14591 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311946.1_prot_XP_020712229.1_11915 2 Reactome: R-HSA-975956;Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311419.1_prot_XP_012254050.1_8082 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" lcl|NW_020311289.1_prot_XP_025601744.1_413 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311433.1_prot_XP_012264043.1_8697 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311479.1_prot_XP_012253348.1_9460 7 Reactome: R-HSA-3108214;Reactome: R-HSA-2173795;Reactome: R-HSA-5685939;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394;Reactome: R-HSA-110362;Reactome: R-HSA-5696400 "SUMOylation of DNA damage response and repair proteins";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"HDR through MMEJ (alt-NHEJ)";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER";"POLB-Dependent Long Patch Base Excision Repair";"Dual Incision in GG-NER" lcl|NW_020311941.1_prot_XP_012253212.1_11410 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311977.1_prot_XP_012253832.1_17499 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" lcl|NW_020311334.1_prot_XP_012265871.1_4408 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311292.1_prot_XP_012262807.1_711 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311962.1_prot_XP_020706676.1_13692 1 Reactome: R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" lcl|NW_020311946.1_prot_XP_012268643.1_11921 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311357.1_prot_XP_020711721.1_5597 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311955.1_prot_XP_012265386.1_12409 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" lcl|NW_020311291.1_prot_XP_012259656.1_465 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" lcl|NW_020311943.1_prot_XP_012255151.1_11641 3 Reactome: R-HSA-8963693;KEGG: 00460+3.5.1.1;KEGG: 00250+3.5.1.1 "Aspartate and asparagine metabolism";"Cyanoamino acid metabolism";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311959.1_prot_XP_012260428.1_13032 2 Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" lcl|NW_020311333.1_prot_XP_012256066.1_4298 4 Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" lcl|NW_020311950.1_prot_XP_012264284.1_12117 56 Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-5610780;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-1236978;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323 "SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Degradation of GLI1 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"G2/M Checkpoints";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling" lcl|NW_020311965.1_prot_XP_012260271.1_14143 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311966.1_prot_XP_012253695.1_14512 3 Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-427413 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"NoRC negatively regulates rRNA expression" lcl|NW_020311292.1_prot_XP_012252422.2_621 3 MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1 "Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism" lcl|NW_020311957.1_prot_XP_012263480.1_12834 3 Reactome: R-HSA-8854214;Reactome: R-HSA-8856828;Reactome: R-HSA-8875656 "TBC/RABGAPs";"Clathrin-mediated endocytosis";"MET receptor recycling" lcl|NW_020311373.1_prot_XP_012266708.1_6466 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311926.1_prot_XP_020706363.1_10598 1 Reactome: R-HSA-418886 "Netrin mediated repulsion signals" lcl|NW_020311972.1_prot_XP_012267907.1_16218 2 MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11 "L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311983.1_prot_XP_012267175.1_19529 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311401.1_prot_XP_012255258.1_7503 4 Reactome: R-HSA-73762;Reactome: R-HSA-8943724;Reactome: R-HSA-427389;Reactome: R-HSA-3214815 "RNA Polymerase I Transcription Initiation";"Regulation of PTEN gene transcription";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones" lcl|NW_020311971.1_prot_XP_020709642.1_15900 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" lcl|NW_020311302.1_prot_XP_012264543.1_1683 1 Reactome: R-HSA-189451 "Heme biosynthesis" lcl|NW_020311331.1_prot_XP_012264307.1_4079 5 Reactome: R-HSA-111457;Reactome: R-HSA-111464;Reactome: R-HSA-9627069;Reactome: R-HSA-111463;Reactome: R-HSA-111469 "Release of apoptotic factors from the mitochondria";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Regulation of the apoptosome activity";"SMAC (DIABLO) binds to IAPs";"SMAC, XIAP-regulated apoptotic response" lcl|NW_020311402.1_prot_XP_012267001.1_7704 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311419.1_prot_XP_020707393.1_8112 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311286.1_prot_XP_020708393.1_222 5 MetaCyc: PWY-6317;MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6 "D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"D-galactose detoxification";"Galactose metabolism" lcl|NW_020311382.1_prot_XP_012268029.1_6850 2 Reactome: R-HSA-5689880;Reactome: R-HSA-8949215 "Ub-specific processing proteases";"Mitochondrial calcium ion transport" lcl|NW_020311418.1_prot_XP_025602044.1_8003 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311391.1_prot_XP_012256741.1_7029 2 Reactome: R-HSA-432722;Reactome: R-HSA-432720 "Golgi Associated Vesicle Biogenesis";"Lysosome Vesicle Biogenesis" lcl|NW_020311981.1_prot_XP_012257369.1_19174 2 Reactome: R-HSA-1660662;Reactome: R-HSA-390471 "Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis" lcl|NW_020311984.1_prot_XP_012254502.1_19954 3 Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Kinesins" lcl|NW_020311932.1_prot_XP_012257419.1_10715 6 KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1855204;KEGG: 00562+3.1.3.36;Reactome: R-HSA-194840 "Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Rho GTPase cycle" lcl|NW_020311513.1_prot_XP_020711391.1_9903 1 Reactome: R-HSA-1483255 "PI Metabolism" lcl|NW_020311309.1_prot_XP_020709061.1_2365 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311974.1_prot_XP_012260002.1_16652 6 Reactome: R-HSA-181429;Reactome: R-HSA-181430;Reactome: R-HSA-210500;Reactome: R-HSA-212676;Reactome: R-HSA-264642;Reactome: R-HSA-388844 "Serotonin Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases" lcl|NW_020311994.1_prot_XP_012260748.1_21518 2 KEGG: 00230+1.7.1.7;Reactome: R-HSA-74217 "Purine metabolism";"Purine salvage" lcl|NW_020311991.1_prot_XP_020706215.1_20913 8 MetaCyc: PWY-7198;MetaCyc: PWY-7210;MetaCyc: PWY-7187;MetaCyc: PWY-7197;Reactome: R-HSA-499943;MetaCyc: PWY-6545;KEGG: 00240+2.7.4.9;MetaCyc: PWY-7184 "Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I" lcl|NW_020311978.1_prot_XP_025602775.1_18051 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311980.1_prot_XP_012261307.1_18862 4 MetaCyc: PWY-6963;KEGG: 00910+1.4.1.14;KEGG: 00250+1.4.1.14;Reactome: R-HSA-73621 "Ammonia assimilation cycle I";"Nitrogen metabolism";"Alanine, aspartate and glutamate metabolism";"Pyrimidine catabolism" lcl|NW_020311395.1_prot_XP_012260695.1_7217 2 Reactome: R-HSA-375276;Reactome: R-HSA-418594 "Peptide ligand-binding receptors";"G alpha (i) signalling events" lcl|NW_020311292.1_prot_XP_020706818.1_673 2 Reactome: R-HSA-446193;KEGG: 00510+2.4.1.256 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis" lcl|NW_020311401.1_prot_XP_012255238.1_7589 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311959.1_prot_XP_012260438.1_13043 2 Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24 "Lysosomal oligosaccharide catabolism";"Other glycan degradation" lcl|NW_020311966.1_prot_XP_012256906.1_14664 1 Reactome: R-HSA-112126 "ALKBH3 mediated reversal of alkylation damage" lcl|NW_020311965.1_prot_XP_012259393.1_14320 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311380.1_prot_XP_012268217.1_6708 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311959.1_prot_XP_012254229.1_13208 1 Reactome: R-HSA-525793 "Myogenesis" lcl|NW_020311436.1_prot_XP_012258114.1_8759 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" lcl|NW_020311958.1_prot_XP_012255299.1_12951 4 Reactome: R-HSA-3359463;Reactome: R-HSA-8964011;Reactome: R-HSA-196741;Reactome: R-HSA-3359462 "Defective CUBN causes hereditary megaloblastic anemia 1";"HDL clearance";"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective AMN causes hereditary megaloblastic anemia 1" lcl|NW_020311975.1_prot_XP_012254384.1_17084 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311300.1_prot_XP_012253164.1_1528 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311448.1_prot_XP_012252702.1_9019 4 KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3 "Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311962.1_prot_XP_012251847.1_13597 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311401.1_prot_XP_012255372.1_7629 2 Reactome: R-HSA-2132295;Reactome: R-HSA-877300 "MHC class II antigen presentation";"Interferon gamma signaling" lcl|NW_020311966.1_prot_XP_012257384.1_14435 1 KEGG: 00970+6.1.1.22 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311974.1_prot_XP_012260200.1_16936 4 KEGG: 00330+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00480+2.5.1.16;KEGG: 00270+2.5.1.16 "Arginine and proline metabolism";"Metabolism of polyamines";"Glutathione metabolism";"Cysteine and methionine metabolism" lcl|NW_020311323.1_prot_XP_020712047.1_3453 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" lcl|NW_020311401.1_prot_XP_020707830.1_7478 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" lcl|NW_020311381.1_prot_XP_020706797.1_6836 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5689880 "UCH proteinases";"Ub-specific processing proteases" lcl|NW_020311983.1_prot_XP_020711788.1_19455 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" lcl|NW_020311369.1_prot_XP_012264138.1_6236 5 MetaCyc: PWY-6168;Reactome: R-HSA-196843;MetaCyc: PWY-5523;KEGG: 00740+2.7.1.26;MetaCyc: PWY-7863 "Flavin biosynthesis III (fungi)";"Vitamin B2 (riboflavin) metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Riboflavin metabolism";"Roseoflavin biosynthesis" lcl|NW_020311971.1_prot_XP_025602673.1_15847 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311977.1_prot_XP_012253999.1_17519 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311313.1_prot_XP_012261815.1_2815 22 MetaCyc: PWY-7601;MetaCyc: PWY-7053;MetaCyc: PWY-7606;MetaCyc: PWY-7592;MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5353;MetaCyc: PWY-6958;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7728;Reactome: R-HSA-75876;MetaCyc: PWY-7726;MetaCyc: PWY-7724;MetaCyc: PWY-7727;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-5080;MetaCyc: PWY-7049;MetaCyc: PWY-7619 "Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Fatty acid elongation";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Synthesis of very long-chain fatty acyl-CoAs";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Juniperonate biosynthesis" lcl|NW_020311982.1_prot_XP_020710897.1_19390 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311995.1_prot_XP_012257012.1_21875 6 MetaCyc: PWY-6906;MetaCyc: PWY-8004;MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6;KEGG: 00030+3.1.1.31;MetaCyc: PWY-5514 "Chitin derivatives degradation";"Entner-Doudoroff pathway I";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Pentose phosphate pathway";"UDP-N-acetyl-D-galactosamine biosynthesis II" lcl|NW_020311966.1_prot_XP_020708233.1_14752 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311983.1_prot_XP_012267229.1_19429 8 Reactome: R-HSA-381676;Reactome: R-HSA-442720;Reactome: R-HSA-180024;Reactome: R-HSA-983231;Reactome: R-HSA-164378;Reactome: R-HSA-432040;Reactome: R-HSA-5610787;Reactome: R-HSA-163615 "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"DARPP-32 events";"Factors involved in megakaryocyte development and platelet production";"PKA activation in glucagon signalling";"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state";"PKA activation" lcl|NW_020311918.1_prot_XP_012265066.1_10409 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase" lcl|NW_020311353.1_prot_XP_020708032.1_5400 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311316.1_prot_XP_025603067.1_3160 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311323.1_prot_XP_012268068.1_3497 1 MetaCyc: PWY-7533 "Gliotoxin biosynthesis" lcl|NW_020311401.1_prot_XP_012254836.1_7486 1 Reactome: R-HSA-3214815 "HDACs deacetylate histones" lcl|NW_020311287.1_prot_XP_012268056.1_287 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311298.1_prot_XP_020706247.1_1230 5 KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00561+3.2.1.22 "Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism";"Stachyose degradation";"Glycerolipid metabolism" lcl|NW_020311507.1_prot_XP_012259670.1_9620 52 Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-76061;Reactome: R-HSA-6807505;Reactome: R-HSA-167242;Reactome: R-HSA-73863;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-168325;Reactome: R-HSA-76066;Reactome: R-HSA-9018519;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-76042;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-112382;Reactome: R-HSA-5250924;Reactome: R-HSA-1834949;Reactome: R-HSA-73780;Reactome: R-HSA-749476;Reactome: R-HSA-73776;Reactome: R-HSA-167238;Reactome: R-HSA-5578749;Reactome: R-HSA-167162;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-5617472;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-5601884;Reactome: R-HSA-73779;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-6781827;Reactome: R-HSA-72086;Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-72203;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-8851708;Reactome: R-HSA-72165;Reactome: R-HSA-203927;Reactome: R-HSA-167161 "Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA polymerase II transcribes snRNA genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase I Transcription Termination";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Viral Messenger RNA Synthesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Estrogen-dependent gene expression";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of RNA Pol II elongation complex";"B-WICH complex positively regulates rRNA expression";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase II Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"Transcriptional regulation by small RNAs";"RNA Polymerase II HIV Promoter Escape";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Capping";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"Processing of Capped Intron-Containing Pre-mRNA";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"Signaling by FGFR2 IIIa TM";"mRNA Splicing - Minor Pathway";"MicroRNA (miRNA) biogenesis";"HIV Transcription Initiation" lcl|NW_020311353.1_prot_XP_020708038.1_5405 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311980.1_prot_XP_012261339.1_18813 2 Reactome: R-HSA-5357956;Reactome: R-HSA-5357905 "TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling" lcl|NW_020311358.1_prot_XP_012255944.1_5673 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" lcl|NW_020311977.1_prot_XP_012263754.1_17882 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311946.1_prot_XP_012268640.1_11928 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311308.1_prot_XP_020710835.1_2181 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311325.1_prot_XP_012253569.1_3664 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311955.1_prot_XP_012265318.1_12366 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311306.1_prot_XP_012264231.1_2082 9 MetaCyc: PWY-6147;MetaCyc: PWY-6703;MetaCyc: PWY-7852;MetaCyc: PWY-6983;KEGG: 00790+3.5.4.16;MetaCyc: PWY-5664;MetaCyc: PWY-7442;Reactome: R-HSA-1474151;MetaCyc: PWY-5663 "6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Preq0 biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Threo-tetrahydrobiopterin biosynthesis";"Folate biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis II";"Drosopterin and aurodrosopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis I" lcl|NW_020311974.1_prot_XP_012259888.1_16916 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" lcl|NW_020311946.1_prot_XP_012268890.1_11882 2 Reactome: R-HSA-72165;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" lcl|NW_020311327.1_prot_XP_012263415.1_3880 3 Reactome: R-HSA-392517;Reactome: R-HSA-418457;Reactome: R-HSA-4086398 "Rap1 signalling";"cGMP effects";"Ca2+ pathway" lcl|NW_020311977.1_prot_XP_012263758.1_17876 2 Reactome: R-HSA-71384;KEGG: 00030+1.1.1.47 "Ethanol oxidation";"Pentose phosphate pathway" lcl|NW_020311296.1_prot_XP_012265471.1_1023 27 Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-3371453;Reactome: R-HSA-5619107;Reactome: R-HSA-168271;Reactome: R-HSA-180746;Reactome: R-HSA-3232142;Reactome: R-HSA-159227;Reactome: R-HSA-3301854;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-4615885;Reactome: R-HSA-4085377;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-165054;Reactome: R-HSA-180910 "NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Regulation of HSF1-mediated heat shock response";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"HCMV Early Events";"ISG15 antiviral mechanism";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA replication proteins";"SUMOylation of SUMOylation proteins";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Rev-mediated nuclear export of HIV RNA";"Vpr-mediated nuclear import of PICs" lcl|NW_020311940.1_prot_XP_012265517.1_11225 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311439.1_prot_XP_020710761.1_8848 2 Reactome: R-HSA-2151201;Reactome: R-HSA-400253 "Transcriptional activation of mitochondrial biogenesis";"Circadian Clock" lcl|NW_020311306.1_prot_XP_012264209.1_2106 1 Reactome: R-HSA-947581 "Molybdenum cofactor biosynthesis" lcl|NW_020311966.1_prot_XP_012256220.1_15044 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311971.1_prot_XP_012263580.1_16122 2 Reactome: R-HSA-399719;Reactome: R-HSA-190873 "Trafficking of AMPA receptors";"Gap junction degradation" lcl|NW_020311364.1_prot_XP_020708946.1_5904 1 Reactome: R-HSA-204626 "Hypusine synthesis from eIF5A-lysine" lcl|NW_020311971.1_prot_XP_012263608.1_16093 7 Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-1834949 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"Cytosolic sensors of pathogen-associated DNA" lcl|NW_020311436.1_prot_XP_020708771.1_8774 3 Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596 "Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I" lcl|NW_020311354.1_prot_XP_025601842.1_5468 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311985.1_prot_XP_012265211.1_20261 6 MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782 "Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311925.1_prot_XP_012252603.1_10527 3 Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340 "PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311973.1_prot_XP_012258786.1_16465 13 Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72706 "Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311396.1_prot_XP_012269545.1_7234 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311458.1_prot_XP_012260972.1_9148 1 Reactome: R-HSA-1483101 "Synthesis of PS" lcl|NW_020311995.1_prot_XP_012257268.1_22000 13 Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-975956 "L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" lcl|NW_020311292.1_prot_XP_012252471.1_503 5 Reactome: R-HSA-8856828;KEGG: 00562+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.36 "Clathrin-mediated endocytosis";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system" lcl|NW_020311432.1_prot_XP_020712307.1_8405 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311353.1_prot_XP_012255968.1_5456 11 Reactome: R-HSA-163680;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9614657;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05170+2.7.11.1;Reactome: R-HSA-380972;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1 "AMPK inhibits chREBP transcriptional activation activity";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"FOXO-mediated transcription of cell death genes";"Human papillomavirus infection";"Regulation of TP53 Activity through Phosphorylation";"Human immunodeficiency virus 1 infection";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signaling pathway";"Relaxin signaling pathway";"Thermogenesis" lcl|NW_020311298.1_prot_XP_020706248.1_1191 5 KEGG: 00230+6.3.5.3;MetaCyc: PWY-6121;MetaCyc: PWY-6122;MetaCyc: PWY-6277;Reactome: R-HSA-73817 "Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"5-aminoimidazole ribonucleotide biosynthesis II";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis" lcl|NW_020311433.1_prot_XP_012263837.1_8654 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" lcl|NW_020311966.1_prot_XP_012256649.1_14684 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311934.1_prot_XP_012255377.1_10823 2 KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20 "Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis" lcl|NW_020311972.1_prot_XP_025602686.1_16238 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" lcl|NW_020311298.1_prot_XP_012250510.1_1145 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311321.1_prot_XP_020710421.1_3410 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311977.1_prot_XP_020710684.1_17728 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311408.1_prot_XP_020710018.1_7801 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311456.1_prot_XP_012255843.1_9114 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311917.1_prot_XP_020706420.1_10227 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311346.1_prot_XP_020710324.1_4992 2 Reactome: R-HSA-418555;Reactome: R-HSA-419812 "G alpha (s) signalling events";"Calcitonin-like ligand receptors" lcl|NW_020311932.1_prot_XP_012252994.1_10685 3 Reactome: R-HSA-6807505;Reactome: R-HSA-749476;Reactome: R-HSA-76071 "RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" lcl|NW_020311982.1_prot_XP_012258408.1_19198 2 Reactome: R-HSA-73980;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311375.1_prot_XP_020708201.1_6535 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311446.1_prot_XP_012261162.1_8949 5 Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-917729;Reactome: R-HSA-162588 "Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion" lcl|NW_020311948.1_prot_XP_012253486.1_12027 6 MetaCyc: PWY-7234;KEGG: 00230+6.3.2.6;MetaCyc: PWY-6123;Reactome: R-HSA-73817;MetaCyc: PWY-6124;KEGG: 00230+4.1.1.21 "Inosine-5'-phosphate biosynthesis III";"Purine metabolism";"Inosine-5'-phosphate biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis II";"Purine metabolism" lcl|NW_020311985.1_prot_XP_012265220.1_20225 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311982.1_prot_XP_012264621.1_19376 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311513.1_prot_XP_012266095.1_9847 19 Reactome: R-HSA-975634;Reactome: R-HSA-8963901;Reactome: R-HSA-3000471;Reactome: R-HSA-432142;Reactome: R-HSA-381426;Reactome: R-HSA-5686938;Reactome: R-HSA-3000497;Reactome: R-HSA-3000484;Reactome: R-HSA-8964026;Reactome: R-HSA-8856828;Reactome: R-HSA-8963888;Reactome: R-HSA-8856825;Reactome: R-HSA-8866423;Reactome: R-HSA-8964046;Reactome: R-HSA-3000480;Reactome: R-HSA-8957275;Reactome: R-HSA-8964041;Reactome: R-HSA-202733;Reactome: R-HSA-8964038 "Retinoid metabolism and transport";"Chylomicron remodeling";"Scavenging by Class B Receptors";"Platelet sensitization by LDL";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Regulation of TLR by endogenous ligand";"Scavenging by Class H Receptors";"Scavenging by Class F Receptors";"Chylomicron clearance";"Clathrin-mediated endocytosis";"Chylomicron assembly";"Cargo recognition for clathrin-mediated endocytosis";"VLDL assembly";"VLDL clearance";"Scavenging by Class A Receptors";"Post-translational protein phosphorylation";"LDL remodeling";"Cell surface interactions at the vascular wall";"LDL clearance" lcl|NW_020311955.1_prot_XP_020711202.1_12426 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311964.1_prot_XP_025602517.1_13872 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311462.1_prot_XP_012252268.1_9216 4 Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387 "Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling" lcl|NW_020311315.1_prot_XP_020711114.1_3113 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311290.1_prot_XP_020707000.1_441 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311539.1_prot_XP_012262776.1_9978 7 Reactome: R-HSA-6811436;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877 "COPI-independent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase" lcl|NW_020311303.1_prot_XP_012264573.1_1722 9 MetaCyc: PWY-8052;MetaCyc: PWY-6351;MetaCyc: PWY-6367;Reactome: R-HSA-416476;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11;Reactome: R-HSA-112043;MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11 "2-arachidonoylglycerol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"D-myo-inositol-5-phosphate metabolism";"G alpha (q) signalling events";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"PLC beta mediated events";"Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism" lcl|NW_020311418.1_prot_XP_020709653.1_8046 3 Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621 "Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism" lcl|NW_020311915.1_prot_XP_020710083.1_10164 2 Reactome: R-HSA-9010553;Reactome: R-HSA-975957 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311971.1_prot_XP_012260824.1_15846 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311978.1_prot_XP_020708560.1_18400 7 Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;MetaCyc: PWY-7511;Reactome: R-HSA-2691232;Reactome: R-HSA-2644606;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096 "NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus" lcl|NW_020311980.1_prot_XP_012261306.1_18861 4 MetaCyc: PWY-6963;KEGG: 00910+1.4.1.14;Reactome: R-HSA-73621;KEGG: 00250+1.4.1.14 "Ammonia assimilation cycle I";"Nitrogen metabolism";"Pyrimidine catabolism";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311401.1_prot_XP_012254757.1_7471 3 Reactome: R-HSA-8876198;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" lcl|NW_020311950.1_prot_XP_012264369.1_12124 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311948.1_prot_XP_012253450.1_12099 5 Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-917977 "ROS and RNS production in phagocytes";"Ion channel transport";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Transferrin endocytosis and recycling" lcl|NW_020311966.1_prot_XP_012256379.1_14953 7 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"RHO GTPases Activate Formins" lcl|NW_020311475.1_prot_XP_020707128.1_9387 16 Reactome: R-HSA-1257604;Reactome: R-HSA-1433557;Reactome: R-HSA-1660499;Reactome: R-HSA-389357;Reactome: R-HSA-6811558;Reactome: R-HSA-2219530;Reactome: R-HSA-912526;Reactome: R-HSA-912631;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-8853659;Reactome: R-HSA-512988;Reactome: R-HSA-416476;Reactome: R-HSA-1266695;Reactome: R-HSA-388841;Reactome: R-HSA-9009391 "PIP3 activates AKT signaling";"Signaling by SCF-KIT";"Synthesis of PIPs at the plasma membrane";"CD28 dependent PI3K/Akt signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin receptor SHC signaling";"Regulation of signaling by CBL";"Rho GTPase cycle";"GPVI-mediated activation cascade";"RET signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"G alpha (q) signalling events";"Interleukin-7 signaling";"Costimulation by the CD28 family";"Extra-nuclear estrogen signaling" lcl|NW_020311298.1_prot_XP_020706281.1_1212 3 Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355 "Nitric oxide stimulates guanylate cyclase";"Purine metabolism";"Smooth Muscle Contraction" lcl|NW_020311450.1_prot_XP_012260286.1_9047 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311993.1_prot_XP_020710336.1_21343 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311441.1_prot_XP_012251179.1_8868 9 Reactome: R-HSA-113501;Reactome: R-HSA-69183;Reactome: R-HSA-69205;Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-174430;Reactome: R-HSA-68952;Reactome: R-HSA-69091;Reactome: R-HSA-69166 "Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Processive synthesis on the lagging strand";"G1/S-Specific Transcription";"Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand synthesis initiation";"DNA replication initiation";"Polymerase switching";"Removal of the Flap Intermediate" lcl|NW_020311436.1_prot_XP_012258432.1_8786 1 Reactome: R-HSA-5689877 "Josephin domain DUBs" lcl|NW_020311979.1_prot_XP_020709210.1_18555 8 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Thermogenesis";"Activation of RAC1";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection" lcl|NW_020311980.1_prot_XP_020709751.1_18874 2 Reactome: R-HSA-8949664;Reactome: R-HSA-8949215 "Processing of SMDT1";"Mitochondrial calcium ion transport" lcl|NW_020311314.1_prot_XP_012252175.1_3085 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" lcl|NW_020311306.1_prot_XP_012264193.1_2076 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311332.1_prot_XP_012256293.1_4158 1 KEGG: 00230+4.6.1.2 "Purine metabolism" lcl|NW_020311980.1_prot_XP_025602829.1_18755 2 Reactome: R-HSA-975577;Reactome: R-HSA-2022854 "N-Glycan antennae elongation";"Keratan sulfate biosynthesis" lcl|NW_020311918.1_prot_XP_012268455.1_10267 4 Reactome: R-HSA-198693;Reactome: R-HSA-9614399;Reactome: R-HSA-9615017;Reactome: R-HSA-5674400 "AKT phosphorylates targets in the nucleus";"Regulation of localization of FOXO transcription factors";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Constitutive Signaling by AKT1 E17K in Cancer" lcl|NW_020311507.1_prot_XP_012259686.1_9624 11 Reactome: R-HSA-418597;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-418594;Reactome: R-HSA-418555;Reactome: R-HSA-432040;Reactome: R-HSA-164378 "G alpha (z) signalling events";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase activating pathway";"PKA activation";"Glucagon signaling in metabolic regulation";"G alpha (i) signalling events";"G alpha (s) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation in glucagon signalling" lcl|NW_020311966.1_prot_XP_012256521.1_14755 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311973.1_prot_XP_012258748.1_16382 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311326.1_prot_XP_012261535.1_3749 2 Reactome: R-HSA-71240;KEGG: 00380+1.13.11.11 "Tryptophan catabolism";"Tryptophan metabolism" lcl|NW_020311287.1_prot_XP_012268112.1_257 3 Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594 "Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events" lcl|NW_020311984.1_prot_XP_012254558.1_20017 1 Reactome: R-HSA-400253 "Circadian Clock" lcl|NW_020311962.1_prot_XP_020706709.1_13810 7 KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311290.1_prot_XP_020706856.1_436 3 Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482 "Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events" lcl|NW_020311983.1_prot_XP_012255624.1_19727 2 Reactome: R-HSA-4641265;Reactome: R-HSA-5339700 "Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP" lcl|NW_020311943.1_prot_XP_020707705.1_11638 3 Reactome: R-HSA-8963693;KEGG: 00460+3.5.1.1;KEGG: 00250+3.5.1.1 "Aspartate and asparagine metabolism";"Cyanoamino acid metabolism";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311313.1_prot_XP_012262022.2_2846 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311463.1_prot_XP_012259279.1_9231 12 MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7409 "Plasmalogen degradation";"Linoleic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)" lcl|NW_020311312.1_prot_XP_020711647.1_2670 5 KEGG: 00480+6.3.2.3;Reactome: R-HSA-174403;MetaCyc: PWY-8043;Reactome: R-HSA-5579006;KEGG: 00270+6.3.2.3 "Glutathione metabolism";"Glutathione synthesis and recycling";"Ophthalmate biosynthesis";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Cysteine and methionine metabolism" lcl|NW_020311966.1_prot_XP_012256290.1_14986 6 Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-176187 "Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Activation of ATR in response to replication stress" lcl|NW_020311286.1_prot_XP_012257181.1_143 6 MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508 "Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis" lcl|NW_020311980.1_prot_XP_020709781.1_18790 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311978.1_prot_XP_020708583.1_18049 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311965.1_prot_XP_020709438.1_14054 57 Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-1236978;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-5687128;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5689880;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-349425;Reactome: R-HSA-6798695;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236 "Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Regulation of RAS by GAPs";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"Cross-presentation of soluble exogenous antigens (endosomes)";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"MAPK6/MAPK4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ub-specific processing proteases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Neutrophil degranulation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs" lcl|NW_020311953.1_prot_XP_012260521.1_12253 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" lcl|NW_020311995.1_prot_XP_012256661.1_22054 2 MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21 "Mitochondrial L-carnitine shuttle";"Fatty acid degradation" lcl|NW_020311940.1_prot_XP_012265620.1_11283 2 Reactome: R-HSA-6807878;Reactome: R-HSA-6811434 "COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311956.1_prot_XP_012254588.1_12581 4 Reactome: R-HSA-5625970;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434 "RHO GTPases activate KTN1";"Kinesins";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311292.1_prot_XP_012262805.1_710 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311286.1_prot_XP_012256277.1_190 8 Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-4615885;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-165054 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"SUMOylation of DNA replication proteins";"Separation of Sister Chromatids";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Rev-mediated nuclear export of HIV RNA" lcl|NW_020311309.1_prot_XP_012259110.1_2247 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311962.1_prot_XP_020706748.1_13771 4 Reactome: R-HSA-446193;Reactome: R-HSA-4551295;KEGG: 00513+2.4.1.131;KEGG: 00510+2.4.1.131 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG11 causes ALG11-CDG (CDG-1p)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis" lcl|NW_020311978.1_prot_XP_012257685.1_18116 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" lcl|NW_020311976.1_prot_XP_012253401.1_17305 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" lcl|NW_020311477.1_prot_XP_012262228.1_9431 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311286.1_prot_XP_012257176.1_142 6 KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;Reactome: R-HSA-114508 "Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Effects of PIP2 hydrolysis" lcl|NW_020311958.1_prot_XP_012254976.1_12922 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311419.1_prot_XP_012254055.1_8087 5 MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109 "Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis" lcl|NW_020311994.1_prot_XP_012267555.1_21804 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311992.1_prot_XP_012266480.1_21270 4 MetaCyc: PWY-5041;MetaCyc: PWY-5912;KEGG: 00270+2.5.1.6;Reactome: R-HSA-156581 "S-adenosyl-L-methionine cycle II";"2'-deoxymugineic acid phytosiderophore biosynthesis";"Cysteine and methionine metabolism";"Methylation" lcl|NW_020311982.1_prot_XP_012258370.1_19205 4 Reactome: R-HSA-3928662;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-8856828 "EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"Clathrin-mediated endocytosis" lcl|NW_020311977.1_prot_XP_012263938.1_17873 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311958.1_prot_XP_012260389.1_12905 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311298.1_prot_XP_020706266.1_1365 3 Reactome: R-HSA-5696395;Reactome: R-HSA-5696394;Reactome: R-HSA-3108214 "Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER";"SUMOylation of DNA damage response and repair proteins" lcl|NW_020311956.1_prot_XP_020706560.1_12636 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311306.1_prot_XP_012264210.1_2104 6 Reactome: R-HSA-5609978;Reactome: R-HSA-70370;KEGG: 00520+2.7.7.12;MetaCyc: PWY-6317;MetaCyc: PWY-6527;KEGG: 00052+2.7.7.12 "Defective GALT can cause Galactosemia";"Galactose catabolism";"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Galactose metabolism" lcl|NW_020311312.1_prot_XP_012266756.1_2636 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311348.1_prot_XP_012269845.1_5127 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311966.1_prot_XP_012251691.1_14566 2 MetaCyc: PWY-7800;MetaCyc: PWY-7799 "Ac/N-end rule pathway";"Arg/N-end rule pathway (eukaryotic)" lcl|NW_020311962.1_prot_XP_012252107.1_13550 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311332.1_prot_XP_012268537.1_4122 3 Reactome: R-HSA-9603798;Reactome: R-HSA-8866654;Reactome: R-HSA-9033241 "Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import" lcl|NW_020311988.1_prot_XP_020706226.1_20624 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311982.1_prot_XP_020708769.1_19275 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311979.1_prot_XP_012259490.1_18571 3 MetaCyc: PWY-1801;KEGG: 00680+3.1.2.12;Reactome: R-HSA-156590 "Formaldehyde oxidation II (glutathione-dependent)";"Methane metabolism";"Glutathione conjugation" lcl|NW_020311958.1_prot_XP_012255288.1_12949 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311943.1_prot_XP_012254978.1_11666 3 KEGG: 00260+3.1.3.3;KEGG: 00680+3.1.3.3;Reactome: R-HSA-977347 "Glycine, serine and threonine metabolism";"Methane metabolism";"Serine biosynthesis" lcl|NW_020311976.1_prot_XP_020707245.1_17241 2 Reactome: R-HSA-8866904;Reactome: R-HSA-8866907 "Negative regulation of activity of TFAP2 (AP-2) family transcription factors";"Activation of the TFAP2 (AP-2) family of transcription factors" lcl|NW_020311327.1_prot_XP_012263417.1_3881 2 Reactome: R-HSA-418457;Reactome: R-HSA-4086398 "cGMP effects";"Ca2+ pathway" lcl|NW_020311956.1_prot_XP_020707530.1_12559 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311312.1_prot_XP_012266861.1_2682 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311961.1_prot_XP_020710234.1_13250 1 MetaCyc: PWY-6829 "Trna methylation (yeast)" lcl|NW_020311976.1_prot_XP_012256913.1_17424 4 KEGG: 00564+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32 "Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism" lcl|NW_020311965.1_prot_XP_012259505.1_14363 3 KEGG: 00270+1.13.11.54;MetaCyc: PWY-4361;Reactome: R-HSA-1237112 "Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Methionine salvage pathway" lcl|NW_020311358.1_prot_XP_012256128.1_5655 5 Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-389957;Reactome: R-HSA-390450 "Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC" lcl|NW_020311918.1_prot_XP_025602261.1_10356 1 Reactome: R-HSA-977443 "GABA receptor activation" lcl|NW_020311984.1_prot_XP_012254560.1_20018 1 Reactome: R-HSA-400253 "Circadian Clock" lcl|NW_020311982.1_prot_XP_012264619.1_19374 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311955.1_prot_XP_012265397.1_12510 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311978.1_prot_XP_012257730.1_18153 1 Reactome: R-HSA-70350 "Fructose catabolism" lcl|NW_020311959.1_prot_XP_020710102.1_13110 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311327.1_prot_XP_012263421.1_3846 3 Reactome: R-HSA-3065678;Reactome: R-HSA-983168;Reactome: R-HSA-3065676 "SUMO is transferred from E1 to E2 (UBE2I, UBC9)";"Antigen processing: Ubiquitination & Proteasome degradation";"SUMO is conjugated to E1 (UBA2:SAE1)" lcl|NW_020311978.1_prot_XP_020708578.1_18045 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311977.1_prot_XP_012263677.1_17796 17 Reactome: R-HSA-163765;Reactome: R-HSA-3371599;KEGG: 00254+6.4.1.2;Reactome: R-HSA-2426168;Reactome: R-HSA-200425;Reactome: R-HSA-196780;KEGG: 00640+6.4.1.2;MetaCyc: PWY-6679;MetaCyc: PWY-4381;MetaCyc: PWY-5789;KEGG: 00620+6.4.1.2;MetaCyc: PWY-5743;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6722;KEGG: 00720+6.4.1.2;MetaCyc: PWY-5966-1;MetaCyc: PWY-5744 "ChREBP activates metabolic gene expression";"Defective HLCS causes multiple carboxylase deficiency";"Aflatoxin biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Carnitine metabolism";"Biotin transport and metabolism";"Propanoate metabolism";"Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Pyruvate metabolism";"3-hydroxypropanoate cycle";"Fatty acid biosynthesis";"Candicidin biosynthesis";"Carbon fixation pathways in prokaryotes";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Glyoxylate assimilation" lcl|NW_020311974.1_prot_XP_012260011.1_16649 6 Reactome: R-HSA-181429;Reactome: R-HSA-181430;Reactome: R-HSA-210500;Reactome: R-HSA-264642;Reactome: R-HSA-212676;Reactome: R-HSA-388844 "Serotonin Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases" lcl|NW_020311978.1_prot_XP_012257953.1_18362 6 MetaCyc: PWY-5097;MetaCyc: PWY-2941;KEGG: 00300+4.3.3.7;MetaCyc: PWY-2942;MetaCyc: PWY-8088;KEGG: 00261+4.3.3.7 "L-lysine biosynthesis VI";"L-lysine biosynthesis II";"Lysine biosynthesis";"L-lysine biosynthesis III";"Dipicolinate biosynthesis";"Monobactam biosynthesis" lcl|NW_020311995.1_prot_XP_012256813.1_21927 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311970.1_prot_XP_012256829.1_15706 10 Reactome: R-HSA-111457;Reactome: R-HSA-611105;Reactome: R-HSA-111463;Reactome: R-HSA-2151201;Reactome: R-HSA-111458;Reactome: R-HSA-3299685;Reactome: R-HSA-111464;Reactome: R-HSA-5628897;Reactome: R-HSA-111459;Reactome: R-HSA-9627069 "Release of apoptotic factors from the mitochondria";"Respiratory electron transport";"SMAC (DIABLO) binds to IAPs";"Transcriptional activation of mitochondrial biogenesis";"Formation of apoptosome";"Detoxification of Reactive Oxygen Species";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"TP53 Regulates Metabolic Genes";"Activation of caspases through apoptosome-mediated cleavage";"Regulation of the apoptosome activity" lcl|NW_020311356.1_prot_XP_020711759.1_5556 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" lcl|NW_020311392.1_prot_XP_012269710.1_7067 12 MetaCyc: PWY-7857;KEGG: 00680+6.2.1.1;KEGG: 00010+6.2.1.1;KEGG: 00640+6.2.1.1;KEGG: 00720+6.2.1.1;MetaCyc: PWY-7118;MetaCyc: PWY-5108;KEGG: 00630+6.2.1.1;MetaCyc: PWY-6672;KEGG: 00620+6.2.1.1;MetaCyc: PWY-5132;MetaCyc: PWY-5133 "Adlupulone and adhumulone biosynthesis";"Methane metabolism";"Glycolysis / Gluconeogenesis";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Chitin degradation to ethanol";"L-isoleucine biosynthesis V";"Glyoxylate and dicarboxylate metabolism";"Cis-genanyl-coa degradation";"Pyruvate metabolism";"Lupulone and humulone biosynthesis";"Colupulone and cohumulone biosynthesis" lcl|NW_020311397.1_prot_XP_020707300.1_7341 3 KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261;Reactome: R-HSA-75109 "Glycerolipid metabolism";"Glycerol degradation I";"Triglyceride biosynthesis" lcl|NW_020311942.1_prot_XP_025602382.1_11457 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" lcl|NW_020311324.1_prot_XP_025603094.1_3547 11 KEGG: 00240+6.3.5.5;KEGG: 00240+2.1.3.2;MetaCyc: PWY-5686;Reactome: R-HSA-500753;KEGG: 00250+6.3.5.5;KEGG: 00250+2.1.3.2;MetaCyc: PWY-7791;KEGG: 00240+3.5.2.3;MetaCyc: PWY-7790;MetaCyc: PWY-7400;MetaCyc: PWY-5154 "Pyrimidine metabolism";"Pyrimidine metabolism";"UMP biosynthesis I";"Pyrimidine biosynthesis";"Alanine, aspartate and glutamate metabolism";"Alanine, aspartate and glutamate metabolism";"UMP biosynthesis III";"Pyrimidine metabolism";"UMP biosynthesis II";"L-arginine biosynthesis IV (archaebacteria)";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)" lcl|NW_020311992.1_prot_XP_012266513.1_21168 24 Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-190861;Reactome: R-HSA-5617833;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-3371497;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-437239;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"Gap junction assembly";"Cilium Assembly";"Resolution of Sister Chromatid Cohesion";"Kinesins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids" lcl|NW_020311959.1_prot_XP_012262407.1_13082 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311977.1_prot_XP_012263909.1_17733 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311941.1_prot_XP_012253211.1_11409 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311993.1_prot_XP_020710379.1_21403 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" lcl|NW_020311373.1_prot_XP_012266711.1_6443 5 KEGG: 00073+2.3.1.20;Reactome: R-HSA-6798695;Reactome: R-HSA-1482883;KEGG: 00561+2.3.1.20;Reactome: R-HSA-75109 "Cutin, suberine and wax biosynthesis";"Neutrophil degranulation";"Acyl chain remodeling of DAG and TAG";"Glycerolipid metabolism";"Triglyceride biosynthesis" lcl|NW_020311299.1_prot_XP_025602563.1_1479 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311648.1_prot_XP_012258828.2_10092 8 MetaCyc: PWY-7863;KEGG: 00740+2.7.7.2;Reactome: R-HSA-196843;MetaCyc: PWY-6167;KEGG: 00740+2.7.1.26+2.7.7.2;KEGG: 00740+2.7.1.26;MetaCyc: PWY-5523;MetaCyc: PWY-6168 "Roseoflavin biosynthesis";"Riboflavin metabolism";"Vitamin B2 (riboflavin) metabolism";"Flavin biosynthesis II (archaea)";"Riboflavin metabolism";"Riboflavin metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Flavin biosynthesis III (fungi)" lcl|NW_020311988.1_prot_XP_012268166.1_20498 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311365.1_prot_XP_012259875.1_5950 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311919.1_prot_XP_012257634.1_10477 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" lcl|NW_020311345.1_prot_XP_020707518.1_4909 26 Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-437239;Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5663220;Reactome: R-HSA-8955332;Reactome: R-HSA-9609690;Reactome: R-HSA-380320;Reactome: R-HSA-190861;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-9619483;Reactome: R-HSA-6807878;Reactome: R-HSA-389960;Reactome: R-HSA-389977;Reactome: R-HSA-1445148;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-3371497;Reactome: R-HSA-5617833;Reactome: R-HSA-2500257;Reactome: R-HSA-983189 "EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Recycling pathway of L1";"Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"Separation of Sister Chromatids";"Aggrephagy";"RHO GTPases Activate Formins";"Carboxyterminal post-translational modifications of tubulin";"HCMV Early Events";"Recruitment of NuMA to mitotic centrosomes";"Gap junction assembly";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Activation of AMPK downstream of NMDARs";"COPI-mediated anterograde transport";"Formation of tubulin folding intermediates by CCT/TriC";"Post-chaperonin tubulin folding pathway";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Cilium Assembly";"Resolution of Sister Chromatid Cohesion";"Kinesins" lcl|NW_020311966.1_prot_XP_012252990.1_14530 1 Reactome: R-HSA-373752 "Netrin-1 signaling" lcl|NW_020311993.1_prot_XP_012262906.1_21454 10 Reactome: R-HSA-8856828;Reactome: R-HSA-917729;Reactome: R-HSA-8875360;Reactome: R-HSA-9635644;Reactome: R-HSA-9636383;Reactome: R-HSA-432720;Reactome: R-HSA-6807004;Reactome: R-HSA-5689880;Reactome: R-HSA-8856825;Reactome: R-HSA-182971 "Clathrin-mediated endocytosis";"Endosomal Sorting Complex Required For Transport (ESCRT)";"InlB-mediated entry of Listeria monocytogenes into host cell";"Inhibition of membrane repair";"Prevention of phagosomal-lysosomal fusion";"Lysosome Vesicle Biogenesis";"Negative regulation of MET activity";"Ub-specific processing proteases";"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation" lcl|NW_020311477.1_prot_XP_012262344.1_9445 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" lcl|NW_020311966.1_prot_XP_020708227.1_14785 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311380.1_prot_XP_012261403.1_6688 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311445.1_prot_XP_012266740.1_8921 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311988.1_prot_XP_020712360.1_20495 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311353.1_prot_XP_012255974.1_5451 13 Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-156827 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression" lcl|NW_020311887.1_prot_XP_012267025.1_10124 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311940.1_prot_XP_012265541.1_11349 3 KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317 "Glycolysis / Gluconeogenesis";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)" lcl|NW_020311966.1_prot_XP_012256374.1_14958 7 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins" lcl|NW_020311950.1_prot_XP_012250674.1_12161 3 Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-6807878 "Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"COPI-mediated anterograde transport" lcl|NW_020311416.1_prot_XP_012253689.1_7940 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311313.1_prot_XP_020709933.1_2839 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311957.1_prot_XP_012262078.1_12727 12 KEGG: 00230+2.7.7.4;KEGG: 00450+2.7.7.4;Reactome: R-HSA-174362;KEGG: 00230+2.7.1.25;KEGG: 00920+2.7.1.25;KEGG: 00920+2.7.7.4;MetaCyc: PWY-5340;MetaCyc: PWY-6932;KEGG: 00261+2.7.7.4;MetaCyc: PWY-6683;Reactome: R-HSA-2408550;MetaCyc: PWY-5278 "Purine metabolism";"Selenocompound metabolism";"Transport and synthesis of PAPS";"Purine metabolism";"Sulfur metabolism";"Sulfur metabolism";"Sulfate activation for sulfonation";"Selenate reduction";"Monobactam biosynthesis";"Assimilatory sulfate reduction III";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Sulfite oxidation III" lcl|NW_020311317.1_prot_XP_012251811.1_3246 1 Reactome: R-HSA-446193 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" lcl|NW_020311432.1_prot_XP_025602074.1_8558 2 Reactome: R-HSA-418594;Reactome: R-HSA-6814122 "G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" lcl|NW_020311964.1_prot_XP_012261975.1_14022 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311971.1_prot_XP_020710526.1_16077 12 Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-6807878 "Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"HCMV Early Events";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"COPI-mediated anterograde transport" lcl|NW_020311943.1_prot_XP_020707677.1_11664 3 KEGG: 00260+3.1.3.3;Reactome: R-HSA-977347;KEGG: 00680+3.1.3.3 "Glycine, serine and threonine metabolism";"Serine biosynthesis";"Methane metabolism" lcl|NW_020311962.1_prot_XP_012252043.1_13741 11 Reactome: R-HSA-202733;Reactome: R-HSA-2024096;Reactome: R-HSA-3656237;Reactome: R-HSA-3000170;Reactome: R-HSA-4420332;Reactome: R-HSA-3656253;Reactome: R-HSA-975634;Reactome: R-HSA-3560801;Reactome: R-HSA-1971475;Reactome: R-HSA-2022928;Reactome: R-HSA-3560783 "Cell surface interactions at the vascular wall";"HS-GAG degradation";"Defective EXT2 causes exostoses 2";"Syndecan interactions";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Retinoid metabolism and transport";"Defective B3GAT3 causes JDSSDHD";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG biosynthesis";"Defective B4GALT7 causes EDS, progeroid type" lcl|NW_020311971.1_prot_XP_020709613.1_15831 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection" lcl|NW_020311333.1_prot_XP_012256014.1_4305 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311961.1_prot_XP_020710190.1_13424 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311943.1_prot_XP_012255181.1_11565 7 Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-606279;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025 "Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Deposition of new CENPA-containing nucleosomes at the centromere";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311396.1_prot_XP_020706142.1_7265 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311513.1_prot_XP_012266089.1_9872 4 Reactome: R-HSA-8849175;MetaCyc: PWY-6482;MetaCyc: PWY-7546;Reactome: R-HSA-5358493 "Threonine catabolism";"Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)";"Synthesis of diphthamide-EEF2" lcl|NW_020311975.1_prot_XP_012251261.1_16955 1 Reactome: R-HSA-5250924 "B-WICH complex positively regulates rRNA expression" lcl|NW_020311472.1_prot_XP_012269261.1_9373 2 Reactome: R-HSA-8866654;MetaCyc: PWY-7511 "E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination" lcl|NW_020311940.1_prot_XP_012265671.1_11268 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" lcl|NW_020311982.1_prot_XP_012258153.1_19308 1 Reactome: R-HSA-6807878 "COPI-mediated anterograde transport" lcl|NW_020311313.1_prot_XP_012261802.1_2886 1 Reactome: R-HSA-8849932 "Synaptic adhesion-like molecules" lcl|NW_020311966.1_prot_XP_012256845.1_14987 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311958.1_prot_XP_012260403.1_12894 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311979.1_prot_XP_012261461.2_18658 1 Reactome: R-HSA-2514859 "Inactivation, recovery and regulation of the phototransduction cascade" lcl|NW_020311934.1_prot_XP_012254847.1_10878 1 Reactome: R-HSA-1474151 "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" lcl|NW_020311343.1_prot_XP_012258464.1_4858 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311298.1_prot_XP_012250595.1_1166 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311991.1_prot_XP_020706211.1_20927 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311393.1_prot_XP_012265788.1_7198 2 Reactome: R-HSA-418457;Reactome: R-HSA-4086398 "cGMP effects";"Ca2+ pathway" lcl|NW_020311333.1_prot_XP_012256095.1_4242 3 Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-674695 "RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events" lcl|NW_020311979.1_prot_XP_020709216.1_18569 3 Reactome: R-HSA-156590;KEGG: 00680+3.1.2.12;MetaCyc: PWY-1801 "Glutathione conjugation";"Methane metabolism";"Formaldehyde oxidation II (glutathione-dependent)" lcl|NW_020311968.1_prot_XP_020707044.1_15445 2 Reactome: R-HSA-5576894;Reactome: R-HSA-1296072 "Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels" lcl|NW_020311974.1_prot_XP_012260338.1_16843 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311983.1_prot_XP_020707904.1_19699 29 Reactome: R-HSA-6796648;Reactome: R-HSA-73863;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-5696400;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-167152;Reactome: R-HSA-6782135;Reactome: R-HSA-73772;Reactome: R-HSA-5696395;Reactome: R-HSA-167158;Reactome: R-HSA-6782210;Reactome: R-HSA-72086;Reactome: R-HSA-76042;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-6781827;Reactome: R-HSA-167246;Reactome: R-HSA-73779 "TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"Dual incision in TC-NER";"RNA Polymerase I Promoter Escape";"Formation of Incision Complex in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Capping";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311354.1_prot_XP_012260723.1_5478 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311957.1_prot_XP_012263402.1_12824 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311364.1_prot_XP_012258904.1_5901 6 MetaCyc: PWY-7346;KEGG: 00053+1.1.1.22;Reactome: R-HSA-173599;MetaCyc: PWY-7820;KEGG: 00520+1.1.1.22;KEGG: 00040+1.1.1.22 "UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)";"Ascorbate and aldarate metabolism";"Formation of the active cofactor, UDP-glucuronate";"Teichuronic acid biosynthesis (B. subtilis 168)";"Amino sugar and nucleotide sugar metabolism";"Pentose and glucuronate interconversions" lcl|NW_020311978.1_prot_XP_012257942.1_18231 4 Reactome: R-HSA-6798695;Reactome: R-HSA-983168;Reactome: R-HSA-6802952;Reactome: R-HSA-1632852 "Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Signaling by BRAF and RAF fusions";"Macroautophagy" lcl|NW_020311438.1_prot_XP_012269009.1_8810 5 Reactome: R-HSA-5689901;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-5693565 "Metalloprotease DUBs";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" lcl|NW_020311393.1_prot_XP_012265731.1_7108 13 Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553 "Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311372.1_prot_XP_020712164.1_6347 1 MetaCyc: PWY-6938 "NADH repair" lcl|NW_020311397.1_prot_XP_012253729.1_7339 3 KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109;MetaCyc: PWY-4261 "Glycerolipid metabolism";"Triglyceride biosynthesis";"Glycerol degradation I" lcl|NW_020311292.1_prot_XP_020706846.1_635 3 MetaCyc: PWY-7159;KEGG: 00860+1.3.3.3;Reactome: R-HSA-189451 "3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis" lcl|NW_020311948.1_prot_XP_012253480.1_12021 7 Reactome: R-HSA-3108214;Reactome: R-HSA-5693571;Reactome: R-HSA-5693565;Reactome: R-HSA-69473;Reactome: R-HSA-983168;Reactome: R-HSA-5693607;MetaCyc: PWY-7511 "SUMOylation of DNA damage response and repair proteins";"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"G2/M DNA damage checkpoint";"Antigen processing: Ubiquitination & Proteasome degradation";"Processing of DNA double-strand break ends";"Protein ubiquitination" lcl|NW_020311338.1_prot_XP_020710373.1_4513 1 Reactome: R-HSA-499943 "Interconversion of nucleotide di- and triphosphates" lcl|NW_020311418.1_prot_XP_012261015.1_8004 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311984.1_prot_XP_012254424.1_19893 1 Reactome: R-HSA-6787450 "tRNA modification in the mitochondrion" lcl|NW_020311327.1_prot_XP_020706976.1_3772 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311973.1_prot_XP_012258769.1_16400 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311969.1_prot_XP_012264804.1_15523 1 Reactome: R-HSA-5626467 "RHO GTPases activate IQGAPs" lcl|NW_020311940.1_prot_XP_012265686.1_11239 56 Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684 "Regulation of RAS by GAPs";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state" lcl|NW_020311907.1_prot_XP_012264882.1_10150 5 Reactome: R-HSA-110329;Reactome: R-HSA-110328;Reactome: R-HSA-5221030;Reactome: R-HSA-110357;Reactome: R-HSA-3108214 "Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"TET1,2,3 and TDG demethylate DNA";"Displacement of DNA glycosylase by APEX1";"SUMOylation of DNA damage response and repair proteins" lcl|NW_020311993.1_prot_XP_012261538.1_21296 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311975.1_prot_XP_012252659.1_17102 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311316.1_prot_XP_012269033.1_3165 2 Reactome: R-HSA-418594;Reactome: R-HSA-375276 "G alpha (i) signalling events";"Peptide ligand-binding receptors" lcl|NW_020311962.1_prot_XP_012251967.1_13772 4 Reactome: R-HSA-446193;Reactome: R-HSA-4551295;KEGG: 00513+2.4.1.131;KEGG: 00510+2.4.1.131 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG11 causes ALG11-CDG (CDG-1p)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis" lcl|NW_020311333.1_prot_XP_020708055.1_4258 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311392.1_prot_XP_012251017.1_7071 1 Reactome: R-HSA-74217 "Purine salvage" lcl|NW_020311360.1_prot_XP_012251633.1_5746 5 Reactome: R-HSA-73621;MetaCyc: PWY-5532;Reactome: R-HSA-73614;KEGG: 00983+2.4.2.3;KEGG: 00240+2.4.2.3 "Pyrimidine catabolism";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine salvage";"Drug metabolism - other enzymes";"Pyrimidine metabolism" lcl|NW_020311298.1_prot_XP_012250543.1_1354 1 Reactome: R-HSA-1614635 "Sulfur amino acid metabolism" lcl|NW_020311975.1_prot_XP_012254061.1_17144 2 Reactome: R-HSA-804914;Reactome: R-HSA-9029569 "Transport of fatty acids";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" lcl|NW_020311972.1_prot_XP_020712004.1_16282 6 Reactome: R-HSA-114508;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7039 "Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Phosphatidate metabolism, as a signaling molecule" lcl|NW_020311397.1_prot_XP_020708710.1_7287 3 Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" lcl|NW_020311973.1_prot_XP_012258721.1_16537 5 Reactome: R-HSA-2132295;Reactome: R-HSA-204005;Reactome: R-HSA-983170;Reactome: R-HSA-1655829;Reactome: R-HSA-5694530 "MHC class II antigen presentation";"COPII-mediated vesicle transport";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER" lcl|NW_020311286.1_prot_XP_012256316.1_63 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311977.1_prot_XP_012253846.1_17570 14 MetaCyc: PWY-5695;KEGG: 00983+1.17.3.2;MetaCyc: PWY-6607;MetaCyc: PWY-6596;KEGG: 00230+1.17.1.4;MetaCyc: PWY-5497;KEGG: 00230+1.17.1.4+1.17.3.2;Reactome: R-HSA-8851680;MetaCyc: PWY-6538;KEGG: 00232+1.17.3.2;Reactome: R-HSA-74259;MetaCyc: PWY-6608;MetaCyc: PWY-6606;MetaCyc: PWY-6999 "Inosine 5'-phosphate degradation";"Drug metabolism - other enzymes";"Guanosine nucleotides degradation I";"Adenosine nucleotides degradation I";"Purine metabolism";"Purine nucleobases degradation II (anaerobic)";"Purine metabolism";"Butyrophilin (BTN) family interactions";"Caffeine degradation III (bacteria, via demethylation)";"Caffeine metabolism";"Purine catabolism";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Theophylline degradation" lcl|NW_020311961.1_prot_XP_012262595.1_13287 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311937.1_prot_XP_012252646.1_11029 3 Reactome: R-HSA-3928662;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213 "EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs" lcl|NW_020311327.1_prot_XP_012263477.1_3888 2 Reactome: R-HSA-8963888;Reactome: R-HSA-8866423 "Chylomicron assembly";"VLDL assembly" lcl|NW_020311396.1_prot_XP_025601984.1_7272 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311971.1_prot_XP_012260852.1_15971 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311966.1_prot_XP_012252934.1_14420 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311966.1_prot_XP_012256878.1_15169 20 KEGG: 00410+1.3.3.6;MetaCyc: PWY-7858;MetaCyc: PWY-7726;MetaCyc: PWY-7340;MetaCyc: PWY-6920;MetaCyc: PWY-7288;MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;KEGG: 00592+1.3.3.6;MetaCyc: PWY-6837;MetaCyc: PWY-7291;MetaCyc: PWY-7337;MetaCyc: PWY-7854;MetaCyc: PWY-7606;Reactome: R-HSA-9033241;MetaCyc: PWY-735;MetaCyc: PWY-7007;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7574;MetaCyc: PWY-7338 "beta-Alanine metabolism";"(5Z)-dodecenoate biosynthesis II";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Peroxisomal protein import";"Jasmonic acid biosynthesis";"Methyl ketone biosynthesis (engineered)";"Propanoate metabolism";"Propanoyl-coa degradation II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)" lcl|NW_020311309.1_prot_XP_012259138.1_2314 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311438.1_prot_XP_012269008.1_8809 2 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.20 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311402.1_prot_XP_012267016.1_7702 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311346.1_prot_XP_012268499.1_5031 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311977.1_prot_XP_012264047.1_17615 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311298.1_prot_XP_012269877.1_1340 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" lcl|NW_020311312.1_prot_XP_012266875.1_2674 5 Reactome: R-HSA-8856825;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Gap junction degradation";"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis" lcl|NW_020311286.1_prot_XP_012256340.1_65 2 Reactome: R-HSA-9033241;Reactome: R-HSA-389661 "Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation" lcl|NW_020311993.1_prot_XP_012261754.1_21456 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311978.1_prot_XP_012257706.1_18136 4 KEGG: 00250+6.3.4.4;Reactome: R-HSA-73817;MetaCyc: PWY-7219;KEGG: 00230+6.3.4.4 "Alanine, aspartate and glutamate metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311980.1_prot_XP_012255740.1_18919 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311374.1_prot_XP_012264517.1_6518 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311965.1_prot_XP_020709472.1_14172 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311959.1_prot_XP_012259599.1_13152 1 Reactome: R-HSA-71288 "Creatine metabolism" lcl|NW_020311303.1_prot_XP_012264575.1_1721 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311994.1_prot_XP_012267546.2_21687 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" lcl|NW_020311357.1_prot_XP_012259415.1_5648 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311966.1_prot_XP_012252946.1_14426 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311365.1_prot_XP_012259761.1_5943 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" lcl|NW_020311955.1_prot_XP_012265317.1_12437 2 Reactome: R-HSA-174403;Reactome: R-HSA-5578998 "Glutathione synthesis and recycling";"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)" lcl|NW_020311984.1_prot_XP_012267687.1_20151 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311361.1_prot_XP_012261554.1_5802 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311353.1_prot_XP_012255933.1_5431 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311433.1_prot_XP_020710668.1_8698 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311304.1_prot_XP_012261090.1_1888 5 Reactome: R-HSA-109704;Reactome: R-HSA-1257604;Reactome: R-HSA-5673001;Reactome: R-HSA-6811558;Reactome: R-HSA-2219530 "PI3K Cascade";"PIP3 activates AKT signaling";"RAF/MAP kinase cascade";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Constitutive Signaling by Aberrant PI3K in Cancer" lcl|NW_020311979.1_prot_XP_012259572.1_18627 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311992.1_prot_XP_012266538.1_21018 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311346.1_prot_XP_012262959.1_4935 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311961.1_prot_XP_012262538.1_13241 1 Reactome: R-HSA-111465 "Apoptotic cleavage of cellular proteins" lcl|NW_020311940.1_prot_XP_012265670.1_11267 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" lcl|NW_020311977.1_prot_XP_012263703.1_17720 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" lcl|NW_020311991.1_prot_XP_012269757.1_20889 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6784531 "Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus" lcl|NW_020311974.1_prot_XP_012260003.1_16651 6 Reactome: R-HSA-388844;Reactome: R-HSA-264642;Reactome: R-HSA-212676;Reactome: R-HSA-210500;Reactome: R-HSA-181430;Reactome: R-HSA-181429 "Receptor-type tyrosine-protein phosphatases";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle" lcl|NW_020311966.1_prot_XP_020707002.1_14413 5 Reactome: R-HSA-5696400;Reactome: R-HSA-5696395;Reactome: R-HSA-5685938;Reactome: R-HSA-6782135;Reactome: R-HSA-6783310 "Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER";"HDR through Single Strand Annealing (SSA)";"Dual incision in TC-NER";"Fanconi Anemia Pathway" lcl|NW_020311298.1_prot_XP_025602428.1_1341 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" lcl|NW_020311372.1_prot_XP_012268406.1_6315 5 Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-77595;Reactome: R-HSA-159231 "RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript" lcl|NW_020311961.1_prot_XP_020710233.1_13253 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311311.1_prot_XP_012250904.1_2458 6 Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-73772;Reactome: R-HSA-427359 "RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"SIRT1 negatively regulates rRNA expression" lcl|NW_020311965.1_prot_XP_012259972.1_14215 5 Reactome: R-HSA-4793954;Reactome: R-HSA-532668;KEGG: 00510+3.2.1.106;MetaCyc: PWY-7918;MetaCyc: PWY-7919 "Defective MOGS causes MOGS-CDG (CDG-2b)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"N-Glycan biosynthesis";"Protein N-glycosylation processing phase (yeast)";"Protein N-glycosylation processing phase (plants and animals)" lcl|NW_020311973.1_prot_XP_012258666.1_16585 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" lcl|NW_020311958.1_prot_XP_012255494.1_12982 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311918.1_prot_XP_012265115.1_10311 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311439.1_prot_XP_012264164.1_8820 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311362.1_prot_XP_012264891.1_5871 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311984.1_prot_XP_020707573.1_19998 5 Reactome: R-HSA-197264;Reactome: R-HSA-1368108;Reactome: R-HSA-6798695;KEGG: 00760+6.3.4.21;MetaCyc: PWY-5381 "Nicotinamide salvaging";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Neutrophil degranulation";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)" lcl|NW_020311984.1_prot_XP_020707572.1_20000 5 MetaCyc: PWY-5381;KEGG: 00760+6.3.4.21;Reactome: R-HSA-6798695;Reactome: R-HSA-1368108;Reactome: R-HSA-197264 "Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"Neutrophil degranulation";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinamide salvaging" lcl|NW_020311978.1_prot_XP_020708569.1_18063 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311941.1_prot_XP_012253138.1_11417 2 Reactome: R-HSA-375276;Reactome: R-HSA-416476 "Peptide ligand-binding receptors";"G alpha (q) signalling events" lcl|NW_020311992.1_prot_XP_012266319.1_21230 8 Reactome: R-HSA-8854518;Reactome: R-HSA-6804115;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-380270 "AURKA Activation by TPX2";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311327.1_prot_XP_012252873.1_3799 9 MetaCyc: PWY-5743;MetaCyc: PWY-6142;MetaCyc: PWY-5789;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5744;MetaCyc: PWY-7117;MetaCyc: PWY-241;MetaCyc: PWY-7115 "3-hydroxypropanoate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type" lcl|NW_020311407.1_prot_XP_020707768.1_7769 20 MetaCyc: PWY-7338;MetaCyc: PWY-7574;MetaCyc: PWY-7007;MetaCyc: PWY-735;Reactome: R-HSA-9033241;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-7854;MetaCyc: PWY-6837;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7337;MetaCyc: PWY-7291;MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-6920;MetaCyc: PWY-7288;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7858 "10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoyl-coa degradation II";"Methyl ketone biosynthesis (engineered)";"Jasmonic acid biosynthesis";"Peroxisomal protein import";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"alpha-Linolenic acid metabolism";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"beta-Alanine metabolism";"(5Z)-dodecenoate biosynthesis II" lcl|NW_020311419.1_prot_XP_020707412.1_8059 15 Reactome: R-HSA-167242;Reactome: R-HSA-167152;Reactome: R-HSA-167158;Reactome: R-HSA-9603505;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-113418 "Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the HIV-1 Early Elongation Complex";"NTRK3 as a dependence receptor";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the Early Elongation Complex" lcl|NW_020311346.1_prot_XP_020710318.1_4939 2 KEGG: 00970+6.1.1.3;Reactome: R-HSA-114608 "Aminoacyl-tRNA biosynthesis";"Platelet degranulation" lcl|NW_020311418.1_prot_XP_025602042.1_8019 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311402.1_prot_XP_012267002.1_7705 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311977.1_prot_XP_025602760.1_17922 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311357.1_prot_XP_012266992.1_5598 10 KEGG: 00230+3.5.2.17;Reactome: R-HSA-3000171;MetaCyc: PWY-7849;Reactome: R-HSA-2453864;Reactome: R-HSA-975634;MetaCyc: PWY-5691;Reactome: R-HSA-2453902;Reactome: R-HSA-977225;MetaCyc: PWY-7394;Reactome: R-HSA-6798695 "Purine metabolism";"Non-integrin membrane-ECM interactions";"Urate conversion to allantoin III";"Retinoid cycle disease events";"Retinoid metabolism and transport";"Urate conversion to allantoin I";"The canonical retinoid cycle in rods (twilight vision)";"Amyloid fiber formation";"Urate conversion to allantoin II";"Neutrophil degranulation" lcl|NW_020311294.1_prot_XP_020711010.1_871 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" lcl|NW_020311526.1_prot_XP_012269451.1_9946 4 MetaCyc: PWY-801;KEGG: 00260+4.2.1.22;Reactome: R-HSA-1614603;KEGG: 00270+4.2.1.22 "Homocysteine and cysteine interconversion";"Glycine, serine and threonine metabolism";"Cysteine formation from homocysteine";"Cysteine and methionine metabolism" lcl|NW_020311966.1_prot_XP_020708409.1_15110 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" lcl|NW_020311380.1_prot_XP_012268222.1_6754 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" lcl|NW_020311968.1_prot_XP_012267694.1_15383 5 Reactome: R-HSA-6811438;Reactome: R-HSA-6811434;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-204005 "Intra-Golgi traffic";"COPI-dependent Golgi-to-ER retrograde traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"COPII-mediated vesicle transport" lcl|NW_020311396.1_prot_XP_025601980.1_7231 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311401.1_prot_XP_012254767.1_7452 5 Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-72163 "Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"mRNA Splicing - Major Pathway" lcl|NW_020311989.1_prot_XP_012263190.1_20775 12 KEGG: 00130+2.5.1.39;MetaCyc: PWY-5857;MetaCyc: PWY-5873;MetaCyc: PWY-5855;MetaCyc: PWY-6708;MetaCyc: PWY-6978;MetaCyc: PWY-5856;Reactome: R-HSA-2142789;MetaCyc: PWY-5870;MetaCyc: PWY-5872;Reactome: R-HSA-1268020;MetaCyc: PWY-5871 "Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Mitochondrial protein import";"Ubiquinol-9 biosynthesis (eukaryotic)" lcl|NW_020311311.1_prot_XP_012250874.1_2478 6 Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68962 "Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Unwinding of DNA";"Activation of the pre-replicative complex" lcl|NW_020311968.1_prot_XP_012253079.1_15455 10 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5357905;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5357956;KEGG: 05165+2.7.11.1;KEGG: 04660+2.7.10.2;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Regulation of TNFR1 signaling";"Relaxin signaling pathway";"TNFR1-induced NFkappaB signaling pathway";"Human papillomavirus infection";"T cell receptor signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway" lcl|NW_020311992.1_prot_XP_012266290.1_21014 13 Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557 "Formation of a pool of free 40S subunits";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis" lcl|NW_020311953.1_prot_XP_012260602.1_12282 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311983.1_prot_XP_020711801.1_19478 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311978.1_prot_XP_012258006.1_18098 1 Reactome: R-HSA-70171 "Glycolysis" lcl|NW_020311432.1_prot_XP_012268872.1_8595 2 Reactome: R-HSA-6783310;Reactome: R-HSA-5693568 "Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311981.1_prot_XP_012257403.1_19032 2 Reactome: R-HSA-163282;Reactome: R-HSA-2151201 "Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311290.1_prot_XP_020706962.1_440 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311298.1_prot_XP_020706290.1_1269 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311380.1_prot_XP_012268221.1_6757 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" lcl|NW_020311955.1_prot_XP_012265407.1_12387 10 MetaCyc: PWY-7328;MetaCyc: PWY-6397;Reactome: R-HSA-70370;MetaCyc: PWY-3821;MetaCyc: PWY-6527;Reactome: R-HSA-5609977;MetaCyc: PWY-6317;KEGG: 00520+5.1.3.2;KEGG: 00052+5.1.3.2;MetaCyc: PWY-7344 "Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Galactose catabolism";"D-galactose detoxification";"Stachyose degradation";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"UDP-alpha-D-galactose biosynthesis" lcl|NW_020311955.1_prot_XP_012265464.1_12488 42 Reactome: R-HSA-5693571;Reactome: R-HSA-427413;Reactome: R-HSA-912446;Reactome: R-HSA-9616222;Reactome: R-HSA-3214841;Reactome: R-HSA-9609690;Reactome: R-HSA-427389;Reactome: R-HSA-212300;Reactome: R-HSA-73728;Reactome: R-HSA-1221632;Reactome: R-HSA-4551638;Reactome: R-HSA-171306;Reactome: R-HSA-69473;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-427359;Reactome: R-HSA-9018519;Reactome: R-HSA-110330;Reactome: R-HSA-3214858;Reactome: R-HSA-110331;Reactome: R-HSA-110328;Reactome: R-HSA-5250924;Reactome: R-HSA-2299718;Reactome: R-HSA-5693607;Reactome: R-HSA-2559586;Reactome: R-HSA-5625886;Reactome: R-HSA-5693565;Reactome: R-HSA-5617472;Reactome: R-HSA-8936459;Reactome: R-HSA-977225;Reactome: R-HSA-5578749;Reactome: R-HSA-3214842;Reactome: R-HSA-2559580;Reactome: R-HSA-3214815;Reactome: R-HSA-9610379;Reactome: R-HSA-3214847;Reactome: R-HSA-606279;Reactome: R-HSA-1912408;Reactome: R-HSA-201722;Reactome: R-HSA-73772;Reactome: R-HSA-5334118;Reactome: R-HSA-110329 "Nonhomologous End-Joining (NHEJ)";"NoRC negatively regulates rRNA expression";"Meiotic recombination";"Transcriptional regulation of granulopoiesis";"PKMTs methylate histone lysines";"HCMV Early Events";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"PRC2 methylates histones and DNA";"RNA Polymerase I Promoter Opening";"Meiotic synapsis";"SUMOylation of chromatin organization proteins";"Packaging Of Telomere Ends";"G2/M DNA damage checkpoint";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"SIRT1 negatively regulates rRNA expression";"Estrogen-dependent gene expression";"Recognition and association of DNA glycosylase with site containing an affected purine";"RMTs methylate histone arginines";"Cleavage of the damaged purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"B-WICH complex positively regulates rRNA expression";"Condensation of Prophase Chromosomes";"Processing of DNA double-strand break ends";"DNA Damage/Telomere Stress Induced Senescence";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Amyloid fiber formation";"Transcriptional regulation by small RNAs";"HDMs demethylate histones";"Oxidative Stress Induced Senescence";"HDACs deacetylate histones";"HCMV Late Events";"HATs acetylate histones";"Deposition of new CENPA-containing nucleosomes at the centromere";"Pre-NOTCH Transcription and Translation";"Formation of the beta-catenin:TCF transactivating complex";"RNA Polymerase I Promoter Escape";"DNA methylation";"Cleavage of the damaged pyrimidine" lcl|NW_020311994.1_prot_XP_020711897.1_21712 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311325.1_prot_XP_012251472.1_3687 3 Reactome: R-HSA-196757;MetaCyc: PWY-2161;KEGG: 00790+6.3.2.17 "Metabolism of folate and pterines";"Folate polyglutamylation";"Folate biosynthesis" lcl|NW_020311984.1_prot_XP_025602890.1_20183 9 Reactome: R-HSA-4420332;Reactome: R-HSA-975634;Reactome: R-HSA-3656253;Reactome: R-HSA-3560801;Reactome: R-HSA-3560783;Reactome: R-HSA-1971475;Reactome: R-HSA-2022928;Reactome: R-HSA-2024096;Reactome: R-HSA-3656237 "Defective B3GALT6 causes EDSP2 and SEMDJL1";"Retinoid metabolism and transport";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective B3GAT3 causes JDSSDHD";"Defective B4GALT7 causes EDS, progeroid type";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG biosynthesis";"HS-GAG degradation";"Defective EXT2 causes exostoses 2" lcl|NW_020311988.1_prot_XP_012260607.1_20561 5 MetaCyc: PWY-5084;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2 "2-oxoglutarate decarboxylation to succinyl-CoA";"Citrate cycle (TCA cycle)";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism" lcl|NW_020311984.1_prot_XP_012254434.1_19971 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311299.1_prot_XP_025602564.1_1414 5 MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922 "Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)" lcl|NW_020311966.1_prot_XP_025602595.1_15115 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" lcl|NW_020311966.1_prot_XP_012257141.2_14964 44 Reactome: R-HSA-2559582;Reactome: R-HSA-74749;Reactome: R-HSA-6802955;Reactome: R-HSA-9635465;Reactome: R-HSA-8939211;Reactome: R-HSA-5675221;Reactome: R-HSA-3371453;Reactome: R-HSA-5654726;Reactome: R-HSA-456926;Reactome: R-HSA-2871796;Reactome: R-HSA-5673001;Reactome: R-HSA-170968;Reactome: R-HSA-198753;Reactome: R-HSA-445144;Reactome: R-HSA-5668599;Reactome: R-HSA-2559585;Reactome: R-HSA-6802952;Reactome: R-HSA-2029482;Reactome: R-HSA-5674499;Reactome: R-HSA-1295596;Reactome: R-HSA-9649948;Reactome: R-HSA-8940973;Reactome: R-HSA-881907;Reactome: R-HSA-450341;Reactome: R-HSA-444257;Reactome: R-HSA-2559580;KEGG: 04150+2.7.11.24;Reactome: R-HSA-6802946;Reactome: R-HSA-162658;Reactome: R-HSA-8943724;Reactome: R-HSA-9627069;Reactome: R-HSA-5654727;Reactome: R-HSA-6811558;Reactome: R-HSA-879415;Reactome: R-HSA-5654733;Reactome: R-HSA-5674135;Reactome: R-HSA-982772;Reactome: R-HSA-112409;Reactome: R-HSA-5663213;Reactome: R-HSA-202670;Reactome: R-HSA-9634638;Reactome: R-HSA-375165;Reactome: R-HSA-6802948;Reactome: R-HSA-5654732 "Senescence-Associated Secretory Phenotype (SASP)";"Signal attenuation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Suppression of apoptosis";"ESR-mediated signaling";"Negative regulation of MAPK pathway";"Regulation of HSF1-mediated heat shock response";"Negative regulation of FGFR1 signaling";"Thrombin signalling through proteinase activated receptors (PARs)";"FCERI mediated MAPK activation";"RAF/MAP kinase cascade";"Frs2-mediated activation";"ERK/MAPK targets";"Signal transduction by L1";"RHO GTPases Activate NADPH Oxidases";"Oncogene Induced Senescence";"Signaling by BRAF and RAF fusions";"Regulation of actin dynamics for phagocytic cup formation";"Negative feedback regulation of MAPK pathway";"Spry regulation of FGF signaling";"Signaling downstream of RAS mutants";"RUNX2 regulates osteoblast differentiation";"Gastrin-CREB signalling pathway via PKC and MAPK";"Activation of the AP-1 family of transcription factors";"RSK activation";"Oxidative Stress Induced Senescence";"mTOR signaling pathway";"Signaling by moderate kinase activity BRAF mutants";"Golgi Cisternae Pericentriolar Stack Reorganization";"Regulation of PTEN gene transcription";"Regulation of the apoptosome activity";"Negative regulation of FGFR2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Advanced glycosylation endproduct receptor signaling";"Negative regulation of FGFR4 signaling";"MAP2K and MAPK activation";"Growth hormone receptor signaling";"RAF-independent MAPK1/3 activation";"RHO GTPases Activate WASPs and WAVEs";"ERKs are inactivated";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"NCAM signaling for neurite out-growth";"Signaling by high-kinase activity BRAF mutants";"Negative regulation of FGFR3 signaling" lcl|NW_020311991.1_prot_XP_012269730.1_20915 8 MetaCyc: PWY-7184;KEGG: 00240+2.7.4.9;MetaCyc: PWY-6545;Reactome: R-HSA-499943;MetaCyc: PWY-7187;MetaCyc: PWY-7197;MetaCyc: PWY-7210;MetaCyc: PWY-7198 "Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV" lcl|NW_020311968.1_prot_XP_020707041.1_15437 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311987.1_prot_XP_020709169.1_20454 5 Reactome: R-HSA-2426168;Reactome: R-HSA-9614657;Reactome: R-HSA-380994;Reactome: R-HSA-1989781;Reactome: R-HSA-381183 "Activation of gene expression by SREBF (SREBP)";"FOXO-mediated transcription of cell death genes";"ATF4 activates genes in response to endoplasmic reticulum stress";"PPARA activates gene expression";"ATF6 (ATF6-alpha) activates chaperone genes" lcl|NW_020311994.1_prot_XP_020711901.1_21744 5 MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7268 "NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)" lcl|NW_020311994.1_prot_XP_012267563.1_21548 9 MetaCyc: PWY-5484;KEGG: 00010+1.2.1.12;Reactome: R-HSA-70171;MetaCyc: PWY-6901;Reactome: R-HSA-70263;MetaCyc: PWY-1042;KEGG: 00710+1.2.1.12;MetaCyc: PWY-7003;MetaCyc: PWY-8004 "Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Glycolysis";"Superpathway of glucose and xylose degradation";"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Carbon fixation in photosynthetic organisms";"Glycerol degradation to butanol";"Entner-Doudoroff pathway I" lcl|NW_020311967.1_prot_XP_012254303.1_15319 31 MetaCyc: PWY-7746;MetaCyc: PWY-5989;MetaCyc: PWY-8047;MetaCyc: PWY-6799;MetaCyc: PWY-5994;MetaCyc: PWY-8012;MetaCyc: PWY-5971;Reactome: R-HSA-9029558;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7388;MetaCyc: PWY-7723;MetaCyc: PWY-5366;MetaCyc: PWY-8049;MetaCyc: PWY-7664;MetaCyc: PWY-5966-1;MetaCyc: PWY-6282;MetaCyc: PWY-7663;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-6113;MetaCyc: PWY-7858;MetaCyc: PWY-5142;MetaCyc: PWYG-321;MetaCyc: PWY-4381;MetaCyc: PWY-5367;Reactome: R-HSA-75105;Reactome: R-HSA-199220;Reactome: R-HSA-163765;MetaCyc: PWY-5973;Reactome: R-HSA-2426168;MetaCyc: PWY-5147;MetaCyc: PWY-6519 "Mycobacterial sulfolipid biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Bryostatin biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Mupirocin biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Biotin metabolism";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Bacterial bioluminescence";"Palmitoleate biosynthesis II (plants and bacteria)";"Pederin biosynthesis";"Oleate biosynthesis IV (anaerobic)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Gondoate biosynthesis (anaerobic)";"Fatty acid biosynthesis";"Superpathway of mycolate biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Acyl-[acyl-carrier protein] thioesterase pathway";"";"Fatty acid biosynthesis initiation (bacteria and plants)";"Petroselinate biosynthesis";"Fatty acyl-CoA biosynthesis";"Vitamin B5 (pantothenate) metabolism";"ChREBP activates metabolic gene expression";"Cis-vaccenate biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis I (plants)";"8-amino-7-oxononanoate biosynthesis I" lcl|NW_020311940.1_prot_XP_012265542.1_11350 3 MetaCyc: PWY-6317;KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3 "D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Glycolysis / Gluconeogenesis" lcl|NW_020311978.1_prot_XP_012257792.1_18446 3 Reactome: R-HSA-5579007;Reactome: R-HSA-5423646;KEGG: 00220+3.5.1.14 "Defective ACY1 causes encephalopathy";"Aflatoxin activation and detoxification";"Arginine biosynthesis" lcl|NW_020311353.1_prot_XP_020708030.1_5398 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311418.1_prot_XP_012261032.1_8045 3 Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621 "Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism" lcl|NW_020311320.1_prot_XP_020712041.1_3370 5 Reactome: R-HSA-73772;Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-73863 "RNA Polymerase I Promoter Escape";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination" lcl|NW_020311970.1_prot_XP_012269107.1_15648 19 Reactome: R-HSA-8866423;Reactome: R-HSA-8856825;Reactome: R-HSA-8964046;Reactome: R-HSA-3000480;Reactome: R-HSA-8957275;Reactome: R-HSA-8964041;Reactome: R-HSA-8964038;Reactome: R-HSA-202733;Reactome: R-HSA-8964026;Reactome: R-HSA-8963888;Reactome: R-HSA-8856828;Reactome: R-HSA-3000484;Reactome: R-HSA-3000497;Reactome: R-HSA-8963901;Reactome: R-HSA-975634;Reactome: R-HSA-432142;Reactome: R-HSA-3000471;Reactome: R-HSA-381426;Reactome: R-HSA-5686938 "VLDL assembly";"Cargo recognition for clathrin-mediated endocytosis";"VLDL clearance";"Scavenging by Class A Receptors";"Post-translational protein phosphorylation";"LDL remodeling";"LDL clearance";"Cell surface interactions at the vascular wall";"Chylomicron clearance";"Chylomicron assembly";"Clathrin-mediated endocytosis";"Scavenging by Class F Receptors";"Scavenging by Class H Receptors";"Chylomicron remodeling";"Retinoid metabolism and transport";"Platelet sensitization by LDL";"Scavenging by Class B Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Regulation of TLR by endogenous ligand" lcl|NW_020311472.1_prot_XP_012269198.1_9310 9 Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-73776;Reactome: R-HSA-6807505;Reactome: R-HSA-76042;Reactome: R-HSA-73779 "HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Promoter Escape";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311976.1_prot_XP_012253583.1_17234 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311383.1_prot_XP_012251554.1_6889 3 KEGG: 00860+2.5.1.141;MetaCyc: PWY-7856;Reactome: R-HSA-189451 "Porphyrin and chlorophyll metabolism";"Heme a biosynthesis";"Heme biosynthesis" lcl|NW_020311292.1_prot_XP_012252475.1_501 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311957.1_prot_XP_020710038.1_12718 3 KEGG: 00130+4.1.1.90;MetaCyc: PWY-7999;Reactome: R-HSA-159740 "Ubiquinone and other terpenoid-quinone biosynthesis";"Vitamin K-epoxide cycle";"Gamma-carboxylation of protein precursors" lcl|NW_020311294.1_prot_XP_012264948.1_861 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" lcl|NW_020311962.1_prot_XP_012252040.1_13567 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311977.1_prot_XP_012263955.1_18030 14 MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-7036;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7725;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601 "Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)" lcl|NW_020311957.1_prot_XP_012263312.1_12853 13 Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557 "Formation of a pool of free 40S subunits";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis" lcl|NW_020311968.1_prot_XP_012253064.1_15442 2 Reactome: R-HSA-1296072;Reactome: R-HSA-5576894 "Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels" lcl|NW_020311982.1_prot_XP_012258403.1_19202 2 Reactome: R-HSA-749476;Reactome: R-HSA-73980 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination" lcl|NW_020311985.1_prot_XP_012265222.1_20227 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311983.1_prot_XP_012267212.1_19490 3 Reactome: R-HSA-983168;Reactome: R-HSA-1358803;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Downregulation of ERBB2:ERBB3 signaling";"Protein ubiquitination" lcl|NW_020311954.1_prot_XP_012268170.1_12335 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" lcl|NW_020311306.1_prot_XP_012264226.1_2100 3 Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+4.1.99.22 "Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis" lcl|NW_020311973.1_prot_XP_012258547.1_16453 57 Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5689880;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-6798695;Reactome: R-HSA-349425;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168 "Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Ub-specific processing proteases";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Neutrophil degranulation";"Autodegradation of the E3 ubiquitin ligase COP1";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of RAS by GAPs";"G2/M Checkpoints";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311970.1_prot_XP_012269097.1_15683 5 Reactome: R-HSA-189451;Reactome: R-HSA-6798695;MetaCyc: PWY-5189;KEGG: 00860+4.2.1.24;MetaCyc: PWY-5188 "Heme biosynthesis";"Neutrophil degranulation";"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)" lcl|NW_020311987.1_prot_XP_012268402.1_20368 3 Reactome: R-HSA-73856;Reactome: R-HSA-111367;Reactome: R-HSA-77588 "RNA Polymerase II Transcription Termination";"SLBP independent Processing of Histone Pre-mRNAs";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" lcl|NW_020311323.1_prot_XP_020712048.1_3458 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311983.1_prot_XP_012267256.1_19412 5 Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-427413 "RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression" lcl|NW_020311995.1_prot_XP_012256757.1_21976 3 Reactome: R-HSA-73843;KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1 "5-Phosphoribose 1-diphosphate biosynthesis";"Purine metabolism";"Pentose phosphate pathway" lcl|NW_020311955.1_prot_XP_012265366.1_12425 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311361.1_prot_XP_012261503.1_5829 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311964.1_prot_XP_025602519.1_13874 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311961.1_prot_XP_012262553.1_13523 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311961.1_prot_XP_012262534.1_13414 9 Reactome: R-HSA-69205;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-69017;Reactome: R-HSA-68949;Reactome: R-HSA-1362277;Reactome: R-HSA-68689;Reactome: R-HSA-68827;Reactome: R-HSA-176187 "G1/S-Specific Transcription";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"CDK-mediated phosphorylation and removal of Cdc6";"Orc1 removal from chromatin";"Transcription of E2F targets under negative control by DREAM complex";"CDC6 association with the ORC:origin complex";"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress" lcl|NW_020311352.1_prot_XP_012253352.1_5370 4 MetaCyc: PWY-8040;MetaCyc: PWY-8072;KEGG: 00473+5.1.1.1;MetaCyc: PWY-7383 "Ansatrienin biosynthesis";"Alanine racemization";"D-Alanine metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)" lcl|NW_020311932.1_prot_XP_012257423.1_10710 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" lcl|NW_020311978.1_prot_XP_020708676.1_18416 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311988.1_prot_XP_020712531.1_20519 6 Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-429958;Reactome: R-HSA-380994 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress" lcl|NW_020311367.1_prot_XP_020709018.1_6093 4 Reactome: R-HSA-77289;Reactome: R-HSA-6799198;Reactome: R-HSA-611105;Reactome: R-HSA-389661 "Mitochondrial Fatty Acid Beta-Oxidation";"Complex I biogenesis";"Respiratory electron transport";"Glyoxylate metabolism and glycine degradation" lcl|NW_020311993.1_prot_XP_012265162.1_21495 2 KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20 "Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism" lcl|NW_020311304.1_prot_XP_012261386.1_1892 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311304.1_prot_XP_012260698.1_1938 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311958.1_prot_XP_025602452.1_12912 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311966.1_prot_XP_012257279.1_14605 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311959.1_prot_XP_012262409.1_13066 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" lcl|NW_020311965.1_prot_XP_020709430.1_14138 1 Reactome: R-HSA-5693568 "Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311959.1_prot_XP_012262292.1_13085 3 Reactome: R-HSA-110314;Reactome: R-HSA-5689880;Reactome: R-HSA-6783310 "Recognition of DNA damage by PCNA-containing replication complex";"Ub-specific processing proteases";"Fanconi Anemia Pathway" lcl|NW_020311377.1_prot_XP_012266629.1_6612 2 Reactome: R-HSA-399719;Reactome: R-HSA-190873 "Trafficking of AMPA receptors";"Gap junction degradation" lcl|NW_020311966.1_prot_XP_012256378.1_14952 7 Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311432.1_prot_XP_020712262.1_8507 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" lcl|NW_020311293.1_prot_XP_012251450.1_796 2 Reactome: R-HSA-9033241;Reactome: R-HSA-389661 "Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation" lcl|NW_020311978.1_prot_XP_025602779.1_18050 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311401.1_prot_XP_012255313.1_7424 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311962.1_prot_XP_020706701.1_13595 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311988.1_prot_XP_020709729.1_20701 3 Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081 "Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling" lcl|NW_020311991.1_prot_XP_012269768.1_20867 14 KEGG: 00561+2.3.1.51;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-7417;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-7411;MetaCyc: PWY-5981;MetaCyc: PWY-7589;MetaCyc: PWY-8053;MetaCyc: PWY-8055 "Glycerolipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis" lcl|NW_020311424.1_prot_XP_012255444.1_8186 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311333.1_prot_XP_012255872.1_4303 7 Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948 "NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus" lcl|NW_020311298.1_prot_XP_020706279.1_1210 3 KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154 "Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase" lcl|NW_020311955.1_prot_XP_012265395.1_12468 24 Reactome: R-HSA-9648025;Reactome: R-HSA-437239;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-380320;Reactome: R-HSA-190861;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-5617833 "EML4 and NUDC in mitotic spindle formation";"Recycling pathway of L1";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Aggrephagy";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"Recruitment of NuMA to mitotic centrosomes";"Gap junction assembly";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Kinesins";"Resolution of Sister Chromatid Cohesion";"Cilium Assembly" lcl|NW_020311993.1_prot_XP_012263205.1_21346 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311326.1_prot_XP_012261524.1_3718 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311393.1_prot_XP_020711295.1_7209 5 Reactome: R-HSA-5628897;Reactome: R-HSA-5625740;Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-75035 "TP53 Regulates Metabolic Genes";"RHO GTPases activate PKNs";"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" lcl|NW_020311984.1_prot_XP_012254667.1_19847 4 Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription" lcl|NW_020311961.1_prot_XP_012262684.1_13359 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311977.1_prot_XP_012263663.1_17849 6 MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84 "Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis" lcl|NW_020311375.1_prot_XP_012256485.2_6557 1 Reactome: R-HSA-1296061 "HCN channels" lcl|NW_020311955.1_prot_XP_012265352.1_12487 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311977.1_prot_XP_020707334.1_17503 1 Reactome: R-HSA-5649702 "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" lcl|NW_020311432.1_prot_XP_012268721.1_8452 4 Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-917977 "ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"Transferrin endocytosis and recycling" lcl|NW_020311313.1_prot_XP_012261973.1_2830 1 MetaCyc: PWY-7799 "Arg/N-end rule pathway (eukaryotic)" lcl|NW_020311358.1_prot_XP_012255905.1_5663 1 Reactome: R-HSA-201681 "TCF dependent signaling in response to WNT" lcl|NW_020311401.1_prot_XP_012255065.1_7632 16 Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-9018519;Reactome: R-HSA-9022692;Reactome: R-HSA-8986944;Reactome: R-HSA-5687128;Reactome: R-HSA-9029569;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-8934593;Reactome: R-HSA-8943723;Reactome: R-HSA-8853884;Reactome: R-HSA-2559585;Reactome: R-HSA-8936459 "Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"Estrogen-dependent gene expression";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by MECP2";"MAPK6/MAPK4 signaling";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"Regulation of RUNX1 Expression and Activity";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by VENTX";"Oncogene Induced Senescence";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311980.1_prot_XP_012253814.1_18743 6 Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-5632684;Reactome: R-HSA-201722 "Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"Hedgehog 'on' state";"Formation of the beta-catenin:TCF transactivating complex" lcl|NW_020311966.1_prot_XP_012256488.1_14885 1 Reactome: R-HSA-202733 "Cell surface interactions at the vascular wall" lcl|NW_020311372.1_prot_XP_025601911.1_6326 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" lcl|NW_020311978.1_prot_XP_012258109.1_18442 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311967.1_prot_XP_012254305.1_15326 6 Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-176187;Reactome: R-HSA-5693616 "G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange" lcl|NW_020311315.1_prot_XP_012265205.1_3133 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311353.1_prot_XP_025601838.1_5461 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311588.1_prot_XP_020708947.2_10057 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311332.1_prot_XP_012268527.1_4109 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311946.1_prot_XP_012268870.1_11876 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311472.1_prot_XP_012269221.1_9325 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311423.1_prot_XP_012251588.1_8162 6 KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.18;MetaCyc: PWY-622;MetaCyc: PWY-7900 "Starch and sucrose metabolism";"Digestion of dietary carbohydrate";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)" lcl|NW_020311401.1_prot_XP_025601994.1_7603 8 Reactome: R-HSA-9639288;Reactome: R-HSA-917977;KEGG: 00195+7.1.2.2;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;MetaCyc: PWY-7980;KEGG: 00190+7.1.2.2 "Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Photosynthesis";"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"ATP biosynthesis";"Oxidative phosphorylation" lcl|NW_020311944.1_prot_XP_020707455.1_11772 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311982.1_prot_XP_012258416.1_19193 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" lcl|NW_020311982.1_prot_XP_020708781.1_19267 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311943.1_prot_XP_020707798.1_11625 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311333.1_prot_XP_012256148.1_4215 13 Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012 "Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency" lcl|NW_020311955.1_prot_XP_020711148.1_12386 10 Reactome: R-HSA-5609977;MetaCyc: PWY-6317;MetaCyc: PWY-6527;MetaCyc: PWY-6397;MetaCyc: PWY-3821;Reactome: R-HSA-70370;MetaCyc: PWY-7328;MetaCyc: PWY-7344;KEGG: 00052+5.1.3.2;KEGG: 00520+5.1.3.2 "Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose detoxification";"Galactose catabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"UDP-alpha-D-galactose biosynthesis";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311458.1_prot_XP_012264682.1_9161 1 Reactome: R-HSA-69273 "Cyclin A/B1/B2 associated events during G2/M transition" lcl|NW_020311312.1_prot_XP_012266892.1_2711 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311960.1_prot_XP_012254158.1_13229 5 MetaCyc: PWY-3821;KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6317;MetaCyc: PWY-6527 "D-galactose detoxification";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation" lcl|NW_020311365.1_prot_XP_020712498.1_6023 2 Reactome: R-HSA-5205685;Reactome: R-HSA-983231 "Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production" lcl|NW_020311418.1_prot_XP_020709690.1_8042 3 Reactome: R-HSA-73621;Reactome: R-HSA-196807;Reactome: R-HSA-74259 "Pyrimidine catabolism";"Nicotinate metabolism";"Purine catabolism" lcl|NW_020311995.1_prot_XP_012256657.1_22056 2 MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21 "Mitochondrial L-carnitine shuttle";"Fatty acid degradation" lcl|NW_020311936.1_prot_XP_012261347.1_10997 5 Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2559580;Reactome: R-HSA-450321;Reactome: R-HSA-2871796 "Activation of the AP-1 family of transcription factors";"mTOR signaling pathway";"Oxidative Stress Induced Senescence";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"FCERI mediated MAPK activation" lcl|NW_020311979.1_prot_XP_012259494.1_18562 1 Reactome: R-HSA-5676934 "Protein repair" lcl|NW_020311289.1_prot_XP_012253949.1_357 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311367.1_prot_XP_012258950.1_6088 2 MetaCyc: PWY-6502;Reactome: R-HSA-2393930 "8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins" lcl|NW_020311356.1_prot_XP_020711758.1_5553 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" lcl|NW_020311965.1_prot_XP_012260080.1_14150 6 Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex" lcl|NW_020311981.1_prot_XP_012257373.1_18983 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311943.1_prot_XP_012255153.1_11643 3 KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00250+3.5.1.1 "Cyanoamino acid metabolism";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311340.1_prot_XP_020706185.1_4684 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311402.1_prot_XP_012267004.1_7696 11 Reactome: R-HSA-163615;Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-5610787;Reactome: R-HSA-170670;Reactome: R-HSA-418597;Reactome: R-HSA-164378;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-418555;Reactome: R-HSA-163359 "PKA activation";"Adenylate cyclase activating pathway";"Purine metabolism";"Hedgehog 'off' state";"Adenylate cyclase inhibitory pathway";"G alpha (z) signalling events";"PKA activation in glucagon signalling";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation" lcl|NW_020311320.1_prot_XP_012259288.1_3353 3 KEGG: 00790+4.2.1.96;MetaCyc: PWY-7158;MetaCyc: PWY-8099 "Folate biosynthesis";"L-phenylalanine degradation V";"Tetrahydropteridine recycling" lcl|NW_020311984.1_prot_XP_012267730.1_20132 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311327.1_prot_XP_012252860.1_3789 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311286.1_prot_XP_012256683.1_52 7 KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311970.1_prot_XP_012259836.1_15594 2 Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" lcl|NW_020311971.1_prot_XP_012260822.1_15845 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311436.1_prot_XP_012258386.1_8749 3 Reactome: R-HSA-212676;Reactome: R-HSA-6794361;Reactome: R-HSA-9609736 "Dopamine Neurotransmitter Release Cycle";"Neurexins and neuroligins";"Assembly and cell surface presentation of NMDA receptors" lcl|NW_020311991.1_prot_XP_020706210.1_20926 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311312.1_prot_XP_012266819.1_2765 5 Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379;Reactome: R-HSA-9615710;Reactome: R-HSA-174490 "Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events";"Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins" lcl|NW_020311291.1_prot_XP_012259657.1_466 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" lcl|NW_020311943.1_prot_XP_012255140.1_11677 2 Reactome: R-HSA-72165;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" lcl|NW_020311976.1_prot_XP_020708623.1_17421 2 Reactome: R-HSA-5620924;Reactome: R-HSA-5610787 "Intraflagellar transport";"Hedgehog 'off' state" lcl|NW_020311955.1_prot_XP_012265456.1_12507 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311312.1_prot_XP_012266833.1_2701 5 Reactome: R-HSA-1445148;Reactome: R-HSA-5628897;Reactome: R-HSA-5625740;Reactome: R-HSA-111447;Reactome: R-HSA-75035 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"TP53 Regulates Metabolic Genes";"RHO GTPases activate PKNs";"Activation of BAD and translocation to mitochondria";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" lcl|NW_020311403.1_prot_XP_012253791.1_7717 5 MetaCyc: PWY-6891;MetaCyc: PWY-6892;KEGG: 00730+2.2.1.7;KEGG: 00900+2.2.1.7;MetaCyc: PWY-7560 "Thiazole biosynthesis II (aerobic bacteria)";"Thiazole biosynthesis I (facultative anaerobic bacteria)";"Thiamine metabolism";"Terpenoid backbone biosynthesis";"Methylerythritol phosphate pathway II" lcl|NW_020311978.1_prot_XP_012257800.1_18280 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection" lcl|NW_020311990.1_prot_XP_012266607.1_20838 2 Reactome: R-HSA-71336;KEGG: 00710+2.7.1.14 "Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms" lcl|NW_020311940.1_prot_XP_020711267.1_11344 3 KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3 "Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis" lcl|NW_020311476.1_prot_XP_012254084.1_9406 11 KEGG: 00230+3.6.1.9;MetaCyc: PWY-6545;KEGG: 00760+3.6.1.9;KEGG: 00240+3.6.1.9;MetaCyc: PWY-7184;KEGG: 00770+3.6.1.9;MetaCyc: PWY-7821;KEGG: 00740+3.6.1.9;MetaCyc: PWY-7206;KEGG: 00500+3.6.1.9;MetaCyc: PWY-7187 "Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Nicotinate and nicotinamide metabolism";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pantothenate and CoA biosynthesis";"Tunicamycin biosynthesis";"Riboflavin metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation";"Starch and sucrose metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II" lcl|NW_020311312.1_prot_XP_012266850.1_2778 7 KEGG: 00562+2.7.8.11;MetaCyc: PWY-7625;KEGG: 04070+2.7.8.11;KEGG: 00564+2.7.8.11;MetaCyc: PWY-6351;Reactome: R-HSA-1483226;MetaCyc: PWY-6352 "Inositol phosphate metabolism";"Phosphatidylinositol biosynthesis II (eukaryotes)";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of PI";"3-phosphoinositide biosynthesis" lcl|NW_020311332.1_prot_XP_012268502.1_4125 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311983.1_prot_XP_012255644.1_19799 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311304.1_prot_XP_012260621.1_1798 6 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311391.1_prot_XP_020708390.1_7035 57 Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-6798695;Reactome: R-HSA-349425;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813 "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Neutrophil degranulation";"Autodegradation of the E3 ubiquitin ligase COP1";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"G2/M Checkpoints";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids" lcl|NW_020311374.1_prot_XP_020710831.1_6523 30 Reactome: R-HSA-5676590;Reactome: R-HSA-2122947;Reactome: R-HSA-5610785;Reactome: R-HSA-400253;Reactome: R-HSA-2644607;Reactome: R-HSA-9020702;Reactome: R-HSA-5610783;Reactome: R-HSA-2644606;Reactome: R-HSA-1170546;Reactome: R-HSA-180534;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-2894862;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-69231;Reactome: R-HSA-9604323;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-2565942;Reactome: R-HSA-5607764;Reactome: R-HSA-5684264;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-187577;Reactome: R-HSA-917937 "NIK-->noncanonical NF-kB signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"GLI3 is processed to GLI3R by the proteasome";"Circadian Clock";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Interleukin-1 signaling";"Degradation of GLI2 by the proteasome";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Prolactin receptor signaling";"Vpu mediated degradation of CD4";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cyclin D associated events in G1";"Negative regulation of NOTCH4 signaling";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"Regulation of PLK1 Activity at G2/M Transition";"CLEC7A (Dectin-1) signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"SCF(Skp2)-mediated degradation of p27/p21";"Iron uptake and transport" lcl|NW_020311448.1_prot_XP_012252671.1_9023 3 KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961;Reactome: R-HSA-196783 "Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis" lcl|NW_020311408.1_prot_XP_020710022.1_7797 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311317.1_prot_XP_012252757.1_3223 2 Reactome: R-HSA-6811438;Reactome: R-HSA-6807878 "Intra-Golgi traffic";"COPI-mediated anterograde transport" lcl|NW_020311966.1_prot_XP_012257244.1_14862 2 Reactome: R-HSA-427413;Reactome: R-HSA-3214847 "NoRC negatively regulates rRNA expression";"HATs acetylate histones" lcl|NW_020311918.1_prot_XP_012264997.1_10374 4 MetaCyc: PWY-7849;MetaCyc: PWY-5691;MetaCyc: PWY-7394;KEGG: 00230+4.1.1.97 "Urate conversion to allantoin III";"Urate conversion to allantoin I";"Urate conversion to allantoin II";"Purine metabolism" lcl|NW_020311971.1_prot_XP_012260875.1_15887 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" lcl|NW_020311499.1_prot_XP_025602182.1_9566 2 Reactome: R-HSA-390471;Reactome: R-HSA-1660662 "Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism" lcl|NW_020311961.1_prot_XP_012262555.1_13524 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311380.1_prot_XP_020711604.1_6659 1 Reactome: R-HSA-419771 "Opsins" lcl|NW_020311528.1_prot_XP_020708817.1_9967 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311978.1_prot_XP_012257768.1_18379 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins" lcl|NW_020311971.1_prot_XP_012263541.1_16088 12 Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-68877 "COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"HCMV Early Events";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Mitotic Prometaphase" lcl|NW_020311500.1_prot_XP_012260029.1_9583 56 Reactome: R-HSA-349425;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-5689880;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-5668541;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-9010553;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610785;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-5610780;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837 "Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"Ub-specific processing proteases";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of RAS by GAPs";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"TNFR2 non-canonical NF-kB pathway";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of expression of SLITs and ROBOs";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"GLI3 is processed to GLI3R by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI1 by the proteasome";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation" lcl|NW_020311292.1_prot_XP_020706874.1_512 10 KEGG: 04070+2.7.1.158;MetaCyc: PWY-6554;MetaCyc: PWY-4661;Reactome: R-HSA-1855167;MetaCyc: PWY-6369;MetaCyc: PWY-6361;MetaCyc: PWY-6372;MetaCyc: PWY-6362;KEGG: 00562+2.7.1.158;Reactome: R-HSA-1855191 "Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol phosphate metabolism";"Synthesis of IPs in the nucleus" lcl|NW_020311971.1_prot_XP_020710495.1_16098 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311976.1_prot_XP_020707168.1_17213 3 Reactome: R-HSA-4420097;Reactome: R-HSA-391160;KEGG: 04660+2.7.10.2 "VEGFA-VEGFR2 Pathway";"Signal regulatory protein family interactions";"T cell receptor signaling pathway" lcl|NW_020311982.1_prot_XP_012258154.1_19307 1 Reactome: R-HSA-6807878 "COPI-mediated anterograde transport" lcl|NW_020311973.1_prot_XP_012258770.1_16397 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311994.1_prot_XP_012267553.1_21802 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311977.1_prot_XP_020710677.1_17761 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311967.1_prot_XP_012254351.1_15310 1 Reactome: R-HSA-5617472 "Activation of anterior HOX genes in hindbrain development during early embryogenesis" lcl|NW_020311992.1_prot_XP_012266360.1_21145 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311419.1_prot_XP_020707394.1_8113 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311343.1_prot_XP_012268671.1_4766 4 Reactome: R-HSA-8875555;Reactome: R-HSA-8875656;Reactome: R-HSA-912631;Reactome: R-HSA-186763 "MET activates RAP1 and RAC1";"MET receptor recycling";"Regulation of signaling by CBL";"Downstream signal transduction" lcl|NW_020311941.1_prot_XP_012253277.1_11427 13 Reactome: R-HSA-5357956;Reactome: R-HSA-975163;Reactome: R-HSA-168638;Reactome: R-HSA-445989;Reactome: R-HSA-937072;Reactome: R-HSA-5607764;Reactome: R-HSA-450302;Reactome: R-HSA-2871837;Reactome: R-HSA-937042;Reactome: R-HSA-9020702;Reactome: R-HSA-450321;Reactome: R-HSA-9645460;Reactome: R-HSA-9014325 "TNFR1-induced NFkappaB signaling pathway";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"NOD1/2 Signaling Pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"CLEC7A (Dectin-1) signaling";"activated TAK1 mediates p38 MAPK activation";"FCERI mediated NF-kB activation";"IRAK2 mediated activation of TAK1 complex";"Interleukin-1 signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Alpha-protein kinase 1 signaling pathway";"TICAM1,TRAF6-dependent induction of TAK1 complex" lcl|NW_020311984.1_prot_XP_012267649.1_20074 6 MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782 "Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311332.1_prot_XP_020712187.1_4126 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311401.1_prot_XP_012255064.1_7634 16 Reactome: R-HSA-8943723;Reactome: R-HSA-8934593;Reactome: R-HSA-2559585;Reactome: R-HSA-8936459;Reactome: R-HSA-8853884;Reactome: R-HSA-9018519;Reactome: R-HSA-9022692;Reactome: R-HSA-8986944;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-9029569 "Regulation of PTEN mRNA translation";"Regulation of RUNX1 Expression and Activity";"Oncogene Induced Senescence";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by VENTX";"Estrogen-dependent gene expression";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by MECP2";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" lcl|NW_020311968.1_prot_XP_012253054.1_15451 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311970.1_prot_XP_012269038.1_15639 4 Reactome: R-HSA-209931;KEGG: 00380+1.14.16.4;MetaCyc: PWY-6030;KEGG: 00790+1.14.16.4 "Serotonin and melatonin biosynthesis";"Tryptophan metabolism";"Serotonin and melatonin biosynthesis";"Folate biosynthesis" lcl|NW_020311955.1_prot_XP_020711203.1_12427 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311994.1_prot_XP_020711855.1_21711 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311982.1_prot_XP_012258402.1_19201 2 Reactome: R-HSA-73980;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311432.1_prot_XP_012268807.2_8371 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311939.1_prot_XP_012251680.1_11069 2 MetaCyc: PWY-6854;Reactome: R-HSA-3299685 "Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species" lcl|NW_020311441.1_prot_XP_012251200.1_8904 2 MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311992.1_prot_XP_020709597.1_20958 1 Reactome: R-HSA-3295583 "TRP channels" lcl|NW_020311971.1_prot_XP_020710530.1_16080 12 Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311936.1_prot_XP_025602331.1_10995 5 Reactome: R-HSA-2559580;Reactome: R-HSA-2871796;Reactome: R-HSA-450321;Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24 "Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"mTOR signaling pathway" lcl|NW_020311367.1_prot_XP_012258936.1_6090 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311965.1_prot_XP_020709185.1_14314 8 KEGG: 00910+4.2.1.1;MetaCyc: PWY-5744;MetaCyc: PWY-241;MetaCyc: PWY-7117;MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142 "Nitrogen metabolism";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)" lcl|NW_020311982.1_prot_XP_012264630.1_19386 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311940.1_prot_XP_012265687.1_11251 2 Reactome: R-HSA-425393;Reactome: R-HSA-5223345 "Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events" lcl|NW_020311978.1_prot_XP_020708564.1_18067 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311966.1_prot_XP_012253681.1_14505 4 Reactome: R-HSA-70263;KEGG: 00500+3.1.3.9;KEGG: 00010+3.1.3.9;KEGG: 00052+3.1.3.9 "Gluconeogenesis";"Starch and sucrose metabolism";"Glycolysis / Gluconeogenesis";"Galactose metabolism" lcl|NW_020311292.1_prot_XP_012252407.1_555 4 KEGG: 00030+1.1.1.49;MetaCyc: PWY-8004;KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268 "Pentose phosphate pathway";"Entner-Doudoroff pathway I";"Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)" lcl|NW_020311300.1_prot_XP_012253192.1_1553 3 Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148 "Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311991.1_prot_XP_012269722.1_20939 10 Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72731;Reactome: R-HSA-381042;Reactome: R-HSA-382556;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-9648895;Reactome: R-HSA-72695;Reactome: R-HSA-72706 "L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Recycling of eIF2:GDP";"PERK regulates gene expression";"ABC-family proteins mediated transport";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Response of EIF2AK1 (HRI) to heme deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311361.1_prot_XP_012261552.1_5806 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311984.1_prot_XP_012264714.1_19831 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311993.1_prot_XP_012261906.1_21401 2 Reactome: R-HSA-8869496;Reactome: R-HSA-6790901 "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation";"rRNA modification in the nucleus and cytosol" lcl|NW_020311917.1_prot_XP_012250982.1_10247 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311396.1_prot_XP_012269591.1_7279 2 Reactome: R-HSA-204626;MetaCyc: PWY-5905 "Hypusine synthesis from eIF5A-lysine";"Hypusine biosynthesis" lcl|NW_020311961.1_prot_XP_012262682.1_13356 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311940.1_prot_XP_020711223.1_11197 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311948.1_prot_XP_012253466.1_12097 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311978.1_prot_XP_020708592.1_18360 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311966.1_prot_XP_012257392.1_14434 8 Reactome: R-HSA-9639288;Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-8943724;Reactome: R-HSA-6798695;Reactome: R-HSA-166208;Reactome: R-HSA-5628897 "Amino acids regulate mTORC1";"Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Regulation of PTEN gene transcription";"Neutrophil degranulation";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes" lcl|NW_020311961.1_prot_XP_012262573.1_13327 1 Reactome: R-HSA-379726 "Mitochondrial tRNA aminoacylation" lcl|NW_020311432.1_prot_XP_012268722.1_8448 5 MetaCyc: PWY-7176;Reactome: R-HSA-499943;MetaCyc: PWY-7177;KEGG: 00240+6.3.4.2;MetaCyc: PWY-7185 "UTP and CTP de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"UTP and CTP dephosphorylation II";"Pyrimidine metabolism";"UTP and CTP dephosphorylation I" lcl|NW_020311477.1_prot_XP_012262227.1_9430 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311372.1_prot_XP_020712149.1_6336 2 KEGG: 00770+6.3.2.5;Reactome: R-HSA-196783 "Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis" lcl|NW_020311970.1_prot_XP_025602642.1_15703 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311302.1_prot_XP_012264493.1_1634 1 Reactome: R-HSA-5656169 "Termination of translesion DNA synthesis" lcl|NW_020311994.1_prot_XP_012267354.1_21601 4 KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541;Reactome: R-HSA-499943;MetaCyc: PWY-7221 "Purine metabolism";"Abacavir metabolism";"Interconversion of nucleotide di- and triphosphates";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311945.1_prot_XP_012261785.1_11828 1 Reactome: R-HSA-8953750 "Transcriptional Regulation by E2F6" lcl|NW_020311965.1_prot_XP_012259601.1_14276 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" lcl|NW_020311824.1_prot_XP_012265000.1_10107 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311965.1_prot_XP_012259825.1_14140 1 Reactome: R-HSA-5693568 "Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311362.1_prot_XP_020710996.1_5873 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311976.1_prot_XP_012257441.1_17359 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" lcl|NW_020311981.1_prot_XP_012257460.1_19074 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311968.1_prot_XP_020707045.1_15443 2 Reactome: R-HSA-5576894;Reactome: R-HSA-1296072 "Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels" lcl|NW_020311925.1_prot_XP_012252605.1_10558 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" lcl|NW_020311345.1_prot_XP_012254293.1_4910 3 Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148 "Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311958.1_prot_XP_025602449.1_12913 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311353.1_prot_XP_012255969.1_5459 11 Reactome: R-HSA-163680;Reactome: R-HSA-9614657;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-380972;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1 "AMPK inhibits chREBP transcriptional activation activity";"FOXO-mediated transcription of cell death genes";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway" lcl|NW_020311981.1_prot_XP_012257552.1_19147 1 Reactome: R-HSA-2142789 "Ubiquinol biosynthesis" lcl|NW_020311973.1_prot_XP_012258578.1_16351 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311970.1_prot_XP_012256560.1_15720 2 Reactome: R-HSA-3299685;Reactome: R-HSA-5628897 "Detoxification of Reactive Oxygen Species";"TP53 Regulates Metabolic Genes" lcl|NW_020311334.1_prot_XP_020711348.1_4340 3 MetaCyc: PWY-4261;Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30 "Glycerol degradation I";"Triglyceride biosynthesis";"Glycerolipid metabolism" lcl|NW_020311304.1_prot_XP_012260017.1_1849 1 Reactome: R-HSA-3108214 "SUMOylation of DNA damage response and repair proteins" lcl|NW_020311981.1_prot_XP_012257608.1_19068 8 Reactome: R-HSA-69166;Reactome: R-HSA-68952;Reactome: R-HSA-69091;Reactome: R-HSA-68962;Reactome: R-HSA-174430;Reactome: R-HSA-174411;Reactome: R-HSA-113501;Reactome: R-HSA-69183 "Removal of the Flap Intermediate";"DNA replication initiation";"Polymerase switching";"Activation of the pre-replicative complex";"Telomere C-strand synthesis initiation";"Polymerase switching on the C-strand of the telomere";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Processive synthesis on the lagging strand" lcl|NW_020311948.1_prot_XP_012253516.1_12092 24 Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-6807878;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-5617833;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-437239;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"COPI-mediated anterograde transport";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Cilium Assembly";"Kinesins";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids" lcl|NW_020311973.1_prot_XP_012258664.1_16577 3 Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340 "PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311309.1_prot_XP_020709059.1_2371 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311976.1_prot_XP_012253585.1_17236 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311286.1_prot_XP_025602289.1_76 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311302.1_prot_XP_020710870.1_1676 3 MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783 "Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis" lcl|NW_020311985.1_prot_XP_012265261.2_20239 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311333.1_prot_XP_012256072.1_4297 4 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311955.1_prot_XP_020711142.1_12380 10 MetaCyc: PWY-7344;KEGG: 00052+5.1.3.2;KEGG: 00520+5.1.3.2;MetaCyc: PWY-6527;MetaCyc: PWY-6317;Reactome: R-HSA-5609977;MetaCyc: PWY-6397;MetaCyc: PWY-3821;Reactome: R-HSA-70370;MetaCyc: PWY-7328 "UDP-alpha-D-galactose biosynthesis";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose detoxification";"Galactose catabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis" lcl|NW_020311330.1_prot_XP_012267956.1_4049 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311973.1_prot_XP_020708874.1_16338 1 Reactome: R-HSA-112126 "ALKBH3 mediated reversal of alkylation damage" lcl|NW_020311403.1_prot_XP_012253786.1_7713 10 Reactome: R-HSA-444257;KEGG: 04151+2.7.11.1;Reactome: R-HSA-442742;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-437239;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1 "RSK activation";"PI3K-Akt signaling pathway";"CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling";"Human papillomavirus infection";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Recycling pathway of L1";"Relaxin signaling pathway";"Thermogenesis" lcl|NW_020311948.1_prot_XP_012253483.1_12028 7 KEGG: 00250+2.4.2.14;MetaCyc: PWY-6121;KEGG: 00230+2.4.2.14;MetaCyc: PWY-6122;MetaCyc: PWY-7282;MetaCyc: PWY-6277;Reactome: R-HSA-73817 "Alanine, aspartate and glutamate metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis II";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis" lcl|NW_020311977.1_prot_XP_012263906.1_17730 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311962.1_prot_XP_012252002.1_13705 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311978.1_prot_XP_020708614.1_18278 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection" lcl|NW_020311346.1_prot_XP_020710317.1_4938 2 Reactome: R-HSA-114608;KEGG: 00970+6.1.1.3 "Platelet degranulation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311978.1_prot_XP_012257695.1_18244 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311971.1_prot_XP_012260830.1_15907 8 KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-437239;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Recycling pathway of L1";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311513.1_prot_XP_020711378.1_9748 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" lcl|NW_020311321.1_prot_XP_012263216.1_3423 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" lcl|NW_020311513.1_prot_XP_012266133.1_9858 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311966.1_prot_XP_012256748.1_15083 7 MetaCyc: PWY-882;MetaCyc: PWY-5659;MetaCyc: PWY-7586;KEGG: 00520+5.4.2.8;MetaCyc: PWY-7456;KEGG: 00051+5.4.2.8;Reactome: R-HSA-446205 "L-ascorbate biosynthesis I (L-galactose pathway)";"GDP-mannose biosynthesis";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Amino sugar and nucleotide sugar metabolism";"Beta-(1,4)-mannan degradation";"Fructose and mannose metabolism";"Synthesis of GDP-mannose" lcl|NW_020311967.1_prot_XP_020707511.1_15280 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311933.1_prot_XP_012252843.1_10767 1 Reactome: R-HSA-499943 "Interconversion of nucleotide di- and triphosphates" lcl|NW_020311962.1_prot_XP_012251863.1_13712 3 MetaCyc: PWY-5669;KEGG: 00564+4.1.1.65;Reactome: R-HSA-1483213 "Phosphatidylserine and phosphatidylethanolamine biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PE" lcl|NW_020311995.1_prot_XP_012257102.1_22069 1 Reactome: R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" lcl|NW_020311984.1_prot_XP_012254468.1_19974 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311971.1_prot_XP_020710497.1_16124 2 Reactome: R-HSA-399719;Reactome: R-HSA-190873 "Trafficking of AMPA receptors";"Gap junction degradation" lcl|NW_020311300.1_prot_XP_020707111.1_1500 7 Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942 "Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition" lcl|NW_020311408.1_prot_XP_020710021.1_7798 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311383.1_prot_XP_012251553.1_6888 3 Reactome: R-HSA-189451;MetaCyc: PWY-7856;KEGG: 00860+2.5.1.141 "Heme biosynthesis";"Heme a biosynthesis";"Porphyrin and chlorophyll metabolism" lcl|NW_020311974.1_prot_XP_012260163.1_16796 3 KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16 "Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer" lcl|NW_020311374.1_prot_XP_012264528.1_6519 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311448.1_prot_XP_012252672.1_9024 3 Reactome: R-HSA-196783;MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33 "Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis" lcl|NW_020311994.1_prot_XP_025603018.1_21513 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311942.1_prot_XP_012252452.1_11460 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" lcl|NW_020311978.1_prot_XP_012257872.1_18374 1 Reactome: R-HSA-203641 "NOSTRIN mediated eNOS trafficking" lcl|NW_020311974.1_prot_XP_012259843.1_16698 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311298.1_prot_XP_012250519.1_1161 6 MetaCyc: PWY-7077;KEGG: 00052+3.5.1.25;Reactome: R-HSA-446210;MetaCyc: PWY-6906;MetaCyc: PWY-7395;KEGG: 00520+3.5.1.25 "N-acetyl-D-galactosamine degradation";"Galactose metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"Chitin derivatives degradation";"D-galactosamine and N-acetyl-D-galactosamine degradation";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311432.1_prot_XP_012268790.1_8481 6 Reactome: R-HSA-428930;Reactome: R-HSA-399997;Reactome: R-HSA-416476;Reactome: R-HSA-418592;Reactome: R-HSA-456926;Reactome: R-HSA-434316 "Thromboxane signalling through TP receptor";"Acetylcholine regulates insulin secretion";"G alpha (q) signalling events";"ADP signalling through P2Y purinoceptor 1";"Thrombin signalling through proteinase activated receptors (PARs)";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion" lcl|NW_020311393.1_prot_XP_012265776.1_7160 16 Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72706 "Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Viral mRNA Translation";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311974.1_prot_XP_012260008.1_16648 6 Reactome: R-HSA-210500;Reactome: R-HSA-181430;Reactome: R-HSA-181429;Reactome: R-HSA-388844;Reactome: R-HSA-264642;Reactome: R-HSA-212676 "Glutamate Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle" lcl|NW_020311513.1_prot_XP_012266219.1_9907 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311502.1_prot_XP_012251084.1_9600 15 KEGG: 00620+2.7.1.40;Reactome: R-HSA-70171;MetaCyc: PWY-7218;MetaCyc: PWY-5723;MetaCyc: PWY-6886;KEGG: 00010+2.7.1.40;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40;MetaCyc: PWY-7383;MetaCyc: PWY-2221;MetaCyc: PWY-6901;MetaCyc: PWY-1042;MetaCyc: PWY-7003;MetaCyc: PWY-6142;MetaCyc: PWY-8004 "Pyruvate metabolism";"Glycolysis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Rubisco shunt";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Superpathway of glucose and xylose degradation";"Glycolysis IV (plant cytosol)";"Glycerol degradation to butanol";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway I" lcl|NW_020311330.1_prot_XP_012267971.1_4034 6 KEGG: 04660+3.1.3.16;Reactome: R-HSA-163560;Reactome: R-HSA-400253;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-2173788 "T cell receptor signaling pathway";"Triglyceride catabolism";"Circadian Clock";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"Downregulation of TGF-beta receptor signaling" lcl|NW_020311978.1_prot_XP_025602780.1_18046 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311321.1_prot_XP_012263256.1_3406 1 KEGG: 00531+3.2.1.35 "Glycosaminoglycan degradation" lcl|NW_020311959.1_prot_XP_012259593.1_13175 4 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription" lcl|NW_020311417.1_prot_XP_025602035.1_7964 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" lcl|NW_020311513.1_prot_XP_012266222.1_9909 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" lcl|NW_020311433.1_prot_XP_012263694.1_8659 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311958.1_prot_XP_012260383.1_12899 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311980.1_prot_XP_020709788.1_18850 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311397.1_prot_XP_020707301.1_7342 3 Reactome: R-HSA-75109;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Triglyceride biosynthesis";"Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311953.1_prot_XP_012260522.1_12254 2 KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685 "Glutathione metabolism";"Detoxification of Reactive Oxygen Species" lcl|NW_020311359.1_prot_XP_020706733.1_5706 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" lcl|NW_020311935.1_prot_XP_012266603.1_10913 4 Reactome: R-HSA-156581;KEGG: 00270+2.5.1.6;MetaCyc: PWY-5041;MetaCyc: PWY-5912 "Methylation";"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II";"2'-deoxymugineic acid phytosiderophore biosynthesis" lcl|NW_020311946.1_prot_XP_020712230.1_11920 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311332.1_prot_XP_012268504.1_4128 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311299.1_prot_XP_012263155.1_1443 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" lcl|NW_020311346.1_prot_XP_012262911.1_5006 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311966.1_prot_XP_020708245.1_14693 3 Reactome: R-HSA-1592389;Reactome: R-HSA-1474228;Reactome: R-HSA-1442490 "Activation of Matrix Metalloproteinases";"Degradation of the extracellular matrix";"Collagen degradation" lcl|NW_020311433.1_prot_XP_020710705.1_8628 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311994.1_prot_XP_012262164.1_21837 13 Reactome: R-HSA-2024101;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;MetaCyc: PWY-6902;MetaCyc: PWY-7883;Reactome: R-HSA-2160916;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-1660662;KEGG: 00513+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00520+3.2.1.52 "CS/DS degradation";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Glycosphingolipid metabolism";"Various types of N-glycan biosynthesis";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311887.1_prot_XP_012267023.1_10125 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311356.1_prot_XP_020711760.1_5557 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" lcl|NW_020311286.1_prot_XP_012256678.1_51 7 KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311980.1_prot_XP_025602832.1_18758 2 Reactome: R-HSA-2022854;Reactome: R-HSA-975577 "Keratan sulfate biosynthesis";"N-Glycan antennae elongation" lcl|NW_020311977.1_prot_XP_025602758.1_17919 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311966.1_prot_XP_012253699.1_14515 3 Reactome: R-HSA-427413;Reactome: R-HSA-400206;Reactome: R-HSA-8936459 "NoRC negatively regulates rRNA expression";"Regulation of lipid metabolism by PPARalpha";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311955.1_prot_XP_012265422.1_12527 179 Reactome: R-HSA-8849469;Reactome: R-HSA-445989;Reactome: R-HSA-8939236;Reactome: R-HSA-2173796;Reactome: R-HSA-5607761;Reactome: R-HSA-975956;Reactome: R-HSA-2173791;Reactome: R-HSA-8948751;Reactome: R-HSA-2644606;Reactome: R-HSA-192823;Reactome: R-HSA-975144;Reactome: R-HSA-1295596;Reactome: R-HSA-5689877;Reactome: R-HSA-1236382;Reactome: R-HSA-450408;Reactome: R-HSA-2691232;Reactome: R-HSA-2559580;Reactome: R-HSA-917937;Reactome: R-HSA-8856828;Reactome: R-HSA-174084;Reactome: R-HSA-9013973;Reactome: R-HSA-8866654;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-110314;Reactome: R-HSA-9613829;Reactome: R-HSA-4641257;Reactome: R-HSA-2894862;Reactome: R-HSA-2467813;Reactome: R-HSA-5610780;Reactome: R-HSA-1234176;Reactome: R-HSA-5654727;Reactome: R-HSA-1236974;Reactome: R-HSA-9010553;Reactome: R-HSA-5693565;Reactome: R-HSA-450321;Reactome: R-HSA-69541;Reactome: R-HSA-5358346;Reactome: R-HSA-9645460;Reactome: R-HSA-2122947;Reactome: R-HSA-162588;Reactome: R-HSA-5675221;Reactome: R-HSA-382556;Reactome: R-HSA-2565942;Reactome: R-HSA-5689901;Reactome: R-HSA-8863795;Reactome: R-HSA-5656121;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-9615710;Reactome: R-HSA-349425;Reactome: R-HSA-936440;Reactome: R-HSA-8854050;Reactome: R-HSA-6782210;Reactome: R-HSA-5654726;Reactome: R-HSA-69231;Reactome: R-HSA-901032;Reactome: R-HSA-209560;Reactome: R-HSA-110312;Reactome: R-HSA-6783310;Reactome: R-HSA-8875360;Reactome: R-HSA-975957;Reactome: R-HSA-209543;Reactome: R-HSA-5689880;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-936964;Reactome: R-HSA-8948747;Reactome: R-HSA-2173788;Reactome: R-HSA-2559585;Reactome: R-HSA-5357956;Reactome: R-HSA-187577;Reactome: R-HSA-5685942;Reactome: R-HSA-2979096;Reactome: R-HSA-174184;Reactome: R-HSA-1253288;Reactome: R-HSA-72764;Reactome: R-HSA-5675482;Reactome: R-HSA-1169091;Reactome: R-HSA-5696400;Reactome: R-HSA-156902;Reactome: R-HSA-4641258;Reactome: R-HSA-2122948;Reactome: R-HSA-2408557;Reactome: R-HSA-3134975;Reactome: R-HSA-5610785;Reactome: R-HSA-174178;Reactome: R-HSA-977225;Reactome: R-HSA-9014325;Reactome: R-HSA-72689;Reactome: R-HSA-68949;Reactome: R-HSA-201681;Reactome: R-HSA-975163;Reactome: R-HSA-937039;Reactome: R-HSA-1358803;Reactome: R-HSA-9636383;Reactome: R-HSA-3322077;Reactome: R-HSA-168927;Reactome: R-HSA-8856825;Reactome: R-HSA-175474;Reactome: R-HSA-8939902;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-202424;Reactome: R-HSA-9646399;Reactome: R-HSA-156827;Reactome: R-HSA-110320;Reactome: R-HSA-9013507;Reactome: R-HSA-5357905;Reactome: R-HSA-5689603;Reactome: R-HSA-400253;Reactome: R-HSA-6804760;Reactome: R-HSA-8852276;Reactome: R-HSA-69017;Reactome: R-HSA-975110;Reactome: R-HSA-69481;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-5668541;Reactome: R-HSA-5607764;Reactome: R-HSA-5689896;Reactome: R-HSA-69601;Reactome: R-HSA-5684264;Reactome: R-HSA-917729;Reactome: R-HSA-182971;Reactome: R-HSA-8951664;Reactome: R-HSA-9633012;Reactome: R-HSA-912631;Reactome: R-HSA-5655862;Reactome: R-HSA-8866652;Reactome: R-HSA-4608870;Reactome: R-HSA-5654733;Reactome: R-HSA-5693607;Reactome: R-HSA-168928;Reactome: R-HSA-6791226;Reactome: R-HSA-937072;Reactome: R-HSA-9637628;Reactome: R-HSA-174490;Reactome: R-HSA-4641263;Reactome: R-HSA-937042;Reactome: R-HSA-6807004;Reactome: R-HSA-174113;Reactome: R-HSA-168638;Reactome: R-HSA-6781823;Reactome: R-HSA-1169408;Reactome: R-HSA-180534;Reactome: R-HSA-174048;Reactome: R-HSA-211733;Reactome: R-HSA-2672351;Reactome: R-HSA-532668;Reactome: R-HSA-72706;Reactome: R-HSA-5632684;Reactome: R-HSA-6804757;Reactome: R-HSA-8876493;Reactome: R-HSA-9033241;Reactome: R-HSA-5656169;Reactome: R-HSA-205043;Reactome: R-HSA-5658442;Reactome: R-HSA-450302;Reactome: R-HSA-6781827;Reactome: R-HSA-5205685;Reactome: R-HSA-2173795;Reactome: R-HSA-179409;Reactome: R-HSA-9604323;Reactome: R-HSA-3785653;Reactome: R-HSA-180585;Reactome: R-HSA-3769402;Reactome: R-HSA-2871837;Reactome: R-HSA-5696397;Reactome: R-HSA-5654732;Reactome: R-HSA-6804756;Reactome: R-HSA-9020702;Reactome: R-HSA-937041;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-5676590;Reactome: R-HSA-1799339;Reactome: R-HSA-5696394;Reactome: R-HSA-68827 "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Dectin-1 mediated noncanonical NF-kB signaling";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Regulation of PTEN stability and activity";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Viral mRNA Translation";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Spry regulation of FGF signaling";"Josephin domain DUBs";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Oxidative Stress Induced Senescence";"Iron uptake and transport";"Clathrin-mediated endocytosis";"Autodegradation of Cdh1 by Cdh1:APC/C";"TICAM1-dependent activation of IRF3/IRF7";"E3 ubiquitin ligases ubiquitinate target proteins";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Recognition of DNA damage by PCNA-containing replication complex";"Chaperone Mediated Autophagy";"Degradation of AXIN";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Separation of Sister Chromatids";"Degradation of GLI1 by the proteasome";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Negative regulation of FGFR2 signaling";"ER-Phagosome pathway";"Regulation of expression of SLITs and ROBOs";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Stabilization of p53";"Hedgehog ligand biogenesis";"Alpha-protein kinase 1 signaling pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Budding and maturation of HIV virion";"Negative regulation of MAPK pathway";"ABC-family proteins mediated transport";"Regulation of PLK1 Activity at G2/M Transition";"Metalloprotease DUBs";"Downregulation of ERBB2 signaling";"Translesion synthesis by POLI";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Late endosomal microautophagy";"Autodegradation of the E3 ubiquitin ligase COP1";"Negative regulators of DDX58/IFIH1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Negative regulation of FGFR1 signaling";"Cyclin D associated events in G1";"ER Quality Control Compartment (ERQC)";"NF-kB is activated and signals survival";"Translesion synthesis by REV1";"Fanconi Anemia Pathway";"InlB-mediated entry of Listeria monocytogenes into host cell";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"p75NTR recruits signalling complexes";"Ub-specific processing proteases";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Regulation of PTEN localization";"Downregulation of TGF-beta receptor signaling";"Oncogene Induced Senescence";"TNFR1-induced NFkappaB signaling pathway";"SCF(Skp2)-mediated degradation of p27/p21";"HDR through Homologous Recombination (HRR)";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Downregulation of ERBB4 signaling";"Eukaryotic Translation Termination";"Regulation of necroptotic cell death";"Activation of NF-kappaB in B cells";"Dual Incision in GG-NER";"Peptide chain elongation";"Degradation of DVL";"Activated NOTCH1 Transmits Signal to the Nucleus";"Selenocysteine synthesis";"Regulation of innate immune responses to cytosolic DNA";"GLI3 is processed to GLI3R by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Amyloid fiber formation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Formation of a pool of free 40S subunits";"Orc1 removal from chromatin";"TCF dependent signaling in response to WNT";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"IRAK1 recruits IKK complex";"Downregulation of ERBB2:ERBB3 signaling";"Prevention of phagosomal-lysosomal fusion";"Glycogen synthesis";"TICAM1, RIP1-mediated IKK complex recruitment";"Cargo recognition for clathrin-mediated endocytosis";"Assembly Of The HIV Virion";"Regulation of RUNX2 expression and activity";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Downstream TCR signaling";"Aggrephagy";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translesion Synthesis by POLH";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Regulation of TNFR1 signaling";"UCH proteinases";"Circadian Clock";"Regulation of TP53 Activity through Methylation";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDK-mediated phosphorylation and removal of Cdc6";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"G2/M Checkpoints";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"TNFR2 non-canonical NF-kB pathway";"CLEC7A (Dectin-1) signaling";"Ovarian tumor domain proteases";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Endosomal Sorting Complex Required For Transport (ESCRT)";"EGFR downregulation";"Neddylation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of signaling by CBL";"Translesion synthesis by POLK";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Asymmetric localization of PCP proteins";"Negative regulation of FGFR4 signaling";"Processing of DNA double-strand break ends";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Major pathway of rRNA processing in the nucleolus and cytosol";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Modulation by Mtb of host immune system";"Membrane binding and targetting of GAG proteins";"Regulation of FZD by ubiquitination";"IRAK2 mediated activation of TAK1 complex";"Negative regulation of MET activity";"SCF-beta-TrCP mediated degradation of Emi1";"NOD1/2 Signaling Pathway";"Formation of TC-NER Pre-Incision Complex";"ISG15 antiviral mechanism";"Vpu mediated degradation of CD4";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Stimuli-sensing channels";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Hedgehog 'on' state";"Regulation of TP53 Degradation";"InlA-mediated entry of Listeria monocytogenes into host cells";"Peroxisomal protein import";"Termination of translesion DNA synthesis";"NRIF signals cell death from the nucleus";"Regulation of RAS by GAPs";"activated TAK1 mediates p38 MAPK activation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Pink/Parkin Mediated Mitophagy";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"APC-Cdc20 mediated degradation of Nek2A";"Negative regulation of NOTCH4 signaling";"Myoclonic epilepsy of Lafora";"Vif-mediated degradation of APOBEC3G";"Deactivation of the beta-catenin transactivating complex";"FCERI mediated NF-kB activation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Negative regulation of FGFR3 signaling";"Regulation of TP53 Activity through Phosphorylation";"Interleukin-1 signaling";"IKK complex recruitment mediated by RIP1";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"NIK-->noncanonical NF-kB signaling";"SRP-dependent cotranslational protein targeting to membrane";"DNA Damage Recognition in GG-NER";"CDT1 association with the CDC6:ORC:origin complex" lcl|NW_020311965.1_prot_XP_012259407.1_14358 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311289.1_prot_XP_012256178.1_395 1 Reactome: R-HSA-611105 "Respiratory electron transport" lcl|NW_020311917.1_prot_XP_020706418.1_10225 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311365.1_prot_XP_012260211.1_5968 2 Reactome: R-HSA-2173788;Reactome: R-HSA-5689603 "Downregulation of TGF-beta receptor signaling";"UCH proteinases" lcl|NW_020311373.1_prot_XP_012251293.1_6495 2 Reactome: R-HSA-373080;Reactome: R-HSA-3238698 "Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking" lcl|NW_020311978.1_prot_XP_020708670.1_18125 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311359.1_prot_XP_012252063.1_5713 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311292.1_prot_XP_012252474.1_500 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311441.1_prot_XP_012251247.1_8893 3 Reactome: R-HSA-189451;MetaCyc: PWY-7159;KEGG: 00860+1.3.3.4 "Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism" lcl|NW_020311974.1_prot_XP_012260284.1_16777 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311292.1_prot_XP_012262856.1_689 4 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-419037 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"NCAM1 interactions" lcl|NW_020311979.1_prot_XP_012259405.1_18492 5 Reactome: R-HSA-211976;Reactome: R-HSA-5579026;Reactome: R-HSA-1362409;Reactome: R-HSA-2395516;Reactome: R-HSA-196108 "Endogenous sterols";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Mitochondrial iron-sulfur cluster biogenesis";"Electron transport from NADPH to Ferredoxin";"Pregnenolone biosynthesis" lcl|NW_020311973.1_prot_XP_012258813.1_16590 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311984.1_prot_XP_020707617.1_20012 1 Reactome: R-HSA-400253 "Circadian Clock" lcl|NW_020311287.1_prot_XP_012267140.1_289 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311965.1_prot_XP_020709361.1_14159 1 Reactome: R-HSA-71262 "Carnitine synthesis" lcl|NW_020311995.1_prot_XP_012256755.1_21975 3 Reactome: R-HSA-73843;KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1 "5-Phosphoribose 1-diphosphate biosynthesis";"Purine metabolism";"Pentose phosphate pathway" lcl|NW_020311966.1_prot_XP_020708277.1_15127 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311975.1_prot_XP_020707602.1_17036 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311994.1_prot_XP_012267554.1_21803 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311976.1_prot_XP_012253523.1_17334 8 Reactome: R-HSA-6804756;Reactome: R-HSA-380972;Reactome: R-HSA-9619483;Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-2151209;Reactome: R-HSA-1632852 "Regulation of TP53 Activity through Phosphorylation";"Energy dependent regulation of mTOR by LKB1-AMPK";"Activation of AMPK downstream of NMDARs";"Lipophagy";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Macroautophagy" lcl|NW_020311961.1_prot_XP_020710200.1_13357 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311948.1_prot_XP_012253487.1_12026 6 MetaCyc: PWY-7234;Reactome: R-HSA-73817;KEGG: 00230+6.3.2.6;MetaCyc: PWY-6123;KEGG: 00230+4.1.1.21;MetaCyc: PWY-6124 "Inosine-5'-phosphate biosynthesis III";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Inosine-5'-phosphate biosynthesis II" lcl|NW_020311961.1_prot_XP_012262710.1_13249 1 MetaCyc: PWY-6829 "Trna methylation (yeast)" lcl|NW_020311302.1_prot_XP_012264584.1_1646 4 Reactome: R-HSA-9020702;Reactome: R-HSA-975144;MetaCyc: PWY-7511;Reactome: R-HSA-937039 "Interleukin-1 signaling";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Protein ubiquitination";"IRAK1 recruits IKK complex" lcl|NW_020311973.1_prot_XP_012258579.1_16339 1 Reactome: R-HSA-112126 "ALKBH3 mediated reversal of alkylation damage" lcl|NW_020311300.1_prot_XP_020707101.1_1541 3 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394;Reactome: R-HSA-3214847 "UCH proteinases";"DNA Damage Recognition in GG-NER";"HATs acetylate histones" lcl|NW_020311326.1_prot_XP_012261528.1_3727 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311993.1_prot_XP_012262601.1_21370 5 Reactome: R-HSA-1222556;KEGG: 00330+1.14.13.39;KEGG: 00220+1.14.13.39;MetaCyc: PWY-4983;Reactome: R-HSA-392154 "ROS and RNS production in phagocytes";"Arginine and proline metabolism";"Arginine biosynthesis";"Nitric oxide biosynthesis II (mammals)";"Nitric oxide stimulates guanylate cyclase" lcl|NW_020311943.1_prot_XP_012255179.1_11562 7 Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-606279;Reactome: R-HSA-9648025 "RHO GTPases Activate Formins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Deposition of new CENPA-containing nucleosomes at the centromere";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311287.1_prot_XP_012268057.1_288 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311982.1_prot_XP_020708778.1_19296 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" lcl|NW_020311289.1_prot_XP_012253891.1_377 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311983.1_prot_XP_020711800.1_19477 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311502.1_prot_XP_012251085.1_9599 15 KEGG: 00620+2.7.1.40;MetaCyc: PWY-7218;Reactome: R-HSA-70171;MetaCyc: PWY-5723;MetaCyc: PWY-6886;KEGG: 00010+2.7.1.40;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40;MetaCyc: PWY-7383;MetaCyc: PWY-2221;MetaCyc: PWY-6901;MetaCyc: PWY-1042;MetaCyc: PWY-7003;MetaCyc: PWY-6142;MetaCyc: PWY-8004 "Pyruvate metabolism";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis";"Rubisco shunt";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Superpathway of glucose and xylose degradation";"Glycolysis IV (plant cytosol)";"Glycerol degradation to butanol";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway I" lcl|NW_020311920.1_prot_XP_012268562.1_10499 6 Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220 "EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins" lcl|NW_020311962.1_prot_XP_012252074.1_13694 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311936.1_prot_XP_025602330.1_10994 5 KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341;Reactome: R-HSA-450321;Reactome: R-HSA-2871796;Reactome: R-HSA-2559580 "mTOR signaling pathway";"Activation of the AP-1 family of transcription factors";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"FCERI mediated MAPK activation";"Oxidative Stress Induced Senescence" lcl|NW_020311985.1_prot_XP_012265153.1_20206 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" lcl|NW_020311955.1_prot_XP_012265449.1_12503 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311365.1_prot_XP_012269357.1_6008 28 Reactome: R-HSA-174437;Reactome: R-HSA-5655862;Reactome: R-HSA-5696395;Reactome: R-HSA-6782210;Reactome: R-HSA-3371511;Reactome: R-HSA-6782135;Reactome: R-HSA-5693616;Reactome: R-HSA-176187;Reactome: R-HSA-110314;Reactome: R-HSA-5358606;Reactome: R-HSA-5656121;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-69473;Reactome: R-HSA-3371453;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801;Reactome: R-HSA-69166;Reactome: R-HSA-6804756;Reactome: R-HSA-5696397;Reactome: R-HSA-110320;Reactome: R-HSA-5696400;Reactome: R-HSA-68962;Reactome: R-HSA-6783310;Reactome: R-HSA-110312;Reactome: R-HSA-5358565;Reactome: R-HSA-5693607;Reactome: R-HSA-912446 "Removal of the Flap Intermediate from the C-strand";"Translesion synthesis by POLK";"Formation of Incision Complex in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HSF1 activation";"Dual incision in TC-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"Recognition of DNA damage by PCNA-containing replication complex";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Translesion synthesis by POLI";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"G2/M DNA damage checkpoint";"Regulation of HSF1-mediated heat shock response";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"Regulation of TP53 Activity through Phosphorylation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion Synthesis by POLH";"Dual Incision in GG-NER";"Activation of the pre-replicative complex";"Fanconi Anemia Pathway";"Translesion synthesis by REV1";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Processing of DNA double-strand break ends";"Meiotic recombination" lcl|NW_020311347.1_prot_XP_012266256.1_5060 1 Reactome: R-HSA-2514853 "Condensation of Prometaphase Chromosomes" lcl|NW_020311988.1_prot_XP_012261004.1_20564 5 KEGG: 00020+1.2.4.2;KEGG: 00380+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084 "Citrate cycle (TCA cycle)";"Tryptophan metabolism";"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA" lcl|NW_020311309.1_prot_XP_012259119.1_2347 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311962.1_prot_XP_020706710.1_13811 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311970.1_prot_XP_020711811.1_15784 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" lcl|NW_020311472.1_prot_XP_012269258.1_9370 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" lcl|NW_020311973.1_prot_XP_020708894.1_16583 3 Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340 "PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311977.1_prot_XP_012263705.1_17718 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" lcl|NW_020311929.1_prot_XP_020712025.1_10672 9 Reactome: R-HSA-1632852;Reactome: R-HSA-9639288;Reactome: R-HSA-5674135;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-6798695 "Macroautophagy";"Amino acids regulate mTORC1";"MAP2K and MAPK activation";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Neutrophil degranulation" lcl|NW_020311972.1_prot_XP_012267867.1_16259 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" lcl|NW_020311432.1_prot_XP_012268598.1_8489 2 Reactome: R-HSA-2022377;Reactome: R-HSA-6798695 "Metabolism of Angiotensinogen to Angiotensins";"Neutrophil degranulation" lcl|NW_020311472.1_prot_XP_012269231.1_9328 1 Reactome: R-HSA-2564830 "Cytosolic iron-sulfur cluster assembly" lcl|NW_020311356.1_prot_XP_012267104.1_5547 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311292.1_prot_XP_012252413.1_566 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311966.1_prot_XP_012256471.1_14883 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311946.1_prot_XP_012268745.1_11898 8 Reactome: R-HSA-70171;KEGG: 00521+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1 "Glycolysis";"Streptomycin biosynthesis";"Starch and sucrose metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis" lcl|NW_020311334.1_prot_XP_020711340.1_4360 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311422.1_prot_XP_020707477.1_8141 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311980.1_prot_XP_025602830.1_18756 2 Reactome: R-HSA-2022854;Reactome: R-HSA-975577 "Keratan sulfate biosynthesis";"N-Glycan antennae elongation" lcl|NW_020311955.1_prot_XP_012265396.1_12509 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311983.1_prot_XP_020711783.1_19446 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311977.1_prot_XP_012253925.1_17505 1 Reactome: R-HSA-5649702 "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" lcl|NW_020311296.1_prot_XP_012265412.1_1004 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311988.1_prot_XP_012254545.1_20502 5 Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-983231;Reactome: R-HSA-3371497 "MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"Factors involved in megakaryocyte development and platelet production";"HSP90 chaperone cycle for steroid hormone receptors (SHR)" lcl|NW_020311513.1_prot_XP_020711408.1_9766 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311971.1_prot_XP_020709643.1_15901 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" lcl|NW_020311432.1_prot_XP_012268607.1_8565 4 Reactome: R-HSA-400511;Reactome: R-HSA-1799339;Reactome: R-HSA-422085;Reactome: R-HSA-381771 "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)" lcl|NW_020311317.1_prot_XP_012250946.1_3236 5 Reactome: R-HSA-2022857;KEGG: 00531+3.1.6.14;Reactome: R-HSA-2206305;Reactome: R-HSA-6798695;Reactome: R-HSA-432720 "Keratan sulfate degradation";"Glycosaminoglycan degradation";"MPS IIID - Sanfilippo syndrome D";"Neutrophil degranulation";"Lysosome Vesicle Biogenesis" lcl|NW_020311992.1_prot_XP_012266329.1_21209 2 Reactome: R-HSA-983168;Reactome: R-HSA-6798695 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation" lcl|NW_020311978.1_prot_XP_012257762.1_18196 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311304.1_prot_XP_012261134.1_1757 5 Reactome: R-HSA-8875360;Reactome: R-HSA-8856828;Reactome: R-HSA-6807004;Reactome: R-HSA-8856825;Reactome: R-HSA-182971 "InlB-mediated entry of Listeria monocytogenes into host cell";"Clathrin-mediated endocytosis";"Negative regulation of MET activity";"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation" lcl|NW_020311948.1_prot_XP_012253481.1_12022 7 MetaCyc: PWY-7511;Reactome: R-HSA-3108214;Reactome: R-HSA-5693571;Reactome: R-HSA-5693565;Reactome: R-HSA-983168;Reactome: R-HSA-69473;Reactome: R-HSA-5693607 "Protein ubiquitination";"SUMOylation of DNA damage response and repair proteins";"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends" lcl|NW_020311994.1_prot_XP_020711900.1_21795 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311971.1_prot_XP_012260844.1_15896 3 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" lcl|NW_020311965.1_prot_XP_020709471.1_14171 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311977.1_prot_XP_012263969.1_17777 2 Reactome: R-HSA-8949613;Reactome: R-HSA-1268020 "Cristae formation";"Mitochondrial protein import" lcl|NW_020311983.1_prot_XP_012255629.1_19808 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311559.1_prot_XP_025602216.1_10040 1 Reactome: R-HSA-611105 "Respiratory electron transport" lcl|NW_020311973.1_prot_XP_012258500.1_16374 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" lcl|NW_020311311.1_prot_XP_025603049.1_2492 1 KEGG: 00900+3.4.24.84 "Terpenoid backbone biosynthesis" lcl|NW_020311361.1_prot_XP_012261502.1_5827 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311963.1_prot_XP_012257660.1_13859 1 Reactome: R-HSA-419771 "Opsins" lcl|NW_020311417.1_prot_XP_020709064.1_7948 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311298.1_prot_XP_020706312.1_1127 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311918.1_prot_XP_012265042.1_10468 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311411.1_prot_XP_012252194.1_7861 1 Reactome: R-HSA-5389840 "Mitochondrial translation elongation" lcl|NW_020311401.1_prot_XP_020707756.1_7577 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311392.1_prot_XP_012269691.1_7058 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311973.1_prot_XP_012258720.1_16536 5 Reactome: R-HSA-2132295;Reactome: R-HSA-983170;Reactome: R-HSA-1655829;Reactome: R-HSA-204005;Reactome: R-HSA-5694530 "MHC class II antigen presentation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"COPII-mediated vesicle transport";"Cargo concentration in the ER" lcl|NW_020311936.1_prot_XP_012261272.1_11013 2 MetaCyc: PWY-5697;KEGG: 00230+3.5.3.4 "Allantoin degradation to ureidoglycolate I (urea producing)";"Purine metabolism" lcl|NW_020311292.1_prot_XP_020706871.1_561 4 KEGG: 00030+1.1.1.49;KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268;MetaCyc: PWY-8004 "Pentose phosphate pathway";"Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Entner-Doudoroff pathway I" lcl|NW_020311936.1_prot_XP_025602329.1_10993 5 Reactome: R-HSA-2871796;Reactome: R-HSA-450321;Reactome: R-HSA-2559580;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341 "FCERI mediated MAPK activation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence";"mTOR signaling pathway";"Activation of the AP-1 family of transcription factors" lcl|NW_020311980.1_prot_XP_012255784.1_18913 26 Reactome: R-HSA-9614657;Reactome: R-HSA-2644606;Reactome: R-HSA-1234158;Reactome: R-HSA-2894862;Reactome: R-HSA-3899300;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-918233;Reactome: R-HSA-3371568;Reactome: R-HSA-5617472;Reactome: R-HSA-933541;Reactome: R-HSA-9018519;Reactome: R-HSA-9013695;Reactome: R-HSA-3134973;Reactome: R-HSA-201722;Reactome: R-HSA-1912408;Reactome: R-HSA-1368082;Reactome: R-HSA-5621575;Reactome: R-HSA-8941856;Reactome: R-HSA-210744;Reactome: R-HSA-9013508;Reactome: R-HSA-9617629;Reactome: R-HSA-8866907;Reactome: R-HSA-3214847;Reactome: R-HSA-1989781 "FOXO-mediated transcription of cell death genes";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of gene expression by Hypoxia-inducible Factor";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SUMOylation of transcription cofactors";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"TRAF3-dependent IRF activation pathway";"Attenuation phase";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF6 mediated IRF7 activation";"Estrogen-dependent gene expression";"NOTCH4 Intracellular Domain Regulates Transcription";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Formation of the beta-catenin:TCF transactivating complex";"Pre-NOTCH Transcription and Translation";"RORA activates gene expression";"CD209 (DC-SIGN) signaling";"RUNX3 regulates NOTCH signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"Activation of the TFAP2 (AP-2) family of transcription factors";"HATs acetylate histones";"PPARA activates gene expression" lcl|NW_020311992.1_prot_XP_012266376.1_21054 4 KEGG: 00053+1.13.99.1;KEGG: 00562+1.13.99.1;Reactome: R-HSA-1855183;MetaCyc: PWY-4841 "Ascorbate and aldarate metabolism";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)" lcl|NW_020311961.1_prot_XP_012262580.2_13408 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" lcl|NW_020311971.1_prot_XP_025602666.1_15862 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311513.1_prot_XP_012266044.1_9775 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311302.1_prot_XP_012264492.1_1633 3 Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination" lcl|NW_020311417.1_prot_XP_025602031.1_7958 3 Reactome: R-HSA-445095;Reactome: R-HSA-8963901;Reactome: R-HSA-6807878 "Interaction between L1 and Ankyrins";"Chylomicron remodeling";"COPI-mediated anterograde transport" lcl|NW_020311976.1_prot_XP_020707169.1_17215 3 Reactome: R-HSA-4420097;Reactome: R-HSA-391160;KEGG: 04660+2.7.10.2 "VEGFA-VEGFR2 Pathway";"Signal regulatory protein family interactions";"T cell receptor signaling pathway" lcl|NW_020311982.1_prot_XP_025602860.1_19337 2 Reactome: R-HSA-3769402;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex" lcl|NW_020311980.1_prot_XP_012261330.1_18780 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311292.1_prot_XP_012252535.1_675 3 KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16 "Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer" lcl|NW_020311296.1_prot_XP_012262875.2_1075 2 Reactome: R-HSA-8873719;Reactome: R-HSA-6803205 "RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" lcl|NW_020311294.1_prot_XP_012264889.1_873 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311971.1_prot_XP_012263542.1_16086 12 Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025 "Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311967.1_prot_XP_012254335.1_15339 4 Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72764 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination" lcl|NW_020311994.1_prot_XP_012267607.1_21533 4 Reactome: R-HSA-162699;Reactome: R-HSA-4719377;Reactome: R-HSA-4717374;Reactome: R-HSA-4719360 "Synthesis of dolichyl-phosphate mannose";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM1 causes DPM1-CDG (CDG-1e)";"Defective DPM3 causes DPM3-CDG (CDG-1o)" lcl|NW_020311978.1_prot_XP_020708667.1_18126 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311329.1_prot_XP_012258912.1_3945 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311453.1_prot_XP_012252705.1_9084 1 Reactome: R-HSA-6811438 "Intra-Golgi traffic" lcl|NW_020311936.1_prot_XP_012261356.1_10999 2 Reactome: R-HSA-8866654;Reactome: R-HSA-9033241 "E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import" lcl|NW_020311965.1_prot_XP_012259709.1_14330 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311304.1_prot_XP_012261435.1_1891 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311374.1_prot_XP_012264648.1_6528 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311979.1_prot_XP_012259696.1_18491 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440 "COPI-mediated anterograde transport";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311943.1_prot_XP_012254969.1_11662 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311982.1_prot_XP_012258136.1_19225 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311360.1_prot_XP_012251597.1_5735 1 Reactome: R-HSA-425366 "Transport of bile salts and organic acids, metal ions and amine compounds" lcl|NW_020311953.1_prot_XP_012260588.1_12270 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311940.1_prot_XP_020711263.1_11250 2 Reactome: R-HSA-425393;Reactome: R-HSA-5223345 "Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events" lcl|NW_020311513.1_prot_XP_012266040.1_9770 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311994.1_prot_XP_012267350.1_21621 4 Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation" lcl|NW_020311934.1_prot_XP_012254711.1_10898 9 KEGG: 00270+2.6.1.5;KEGG: 00401+2.6.1.5;KEGG: 00360+2.6.1.5;KEGG: 00950+2.6.1.5;Reactome: R-HSA-8963684;KEGG: 00130+2.6.1.5;KEGG: 00350+2.6.1.5;KEGG: 00960+2.6.1.5;KEGG: 00400+2.6.1.5 "Cysteine and methionine metabolism";"Novobiocin biosynthesis";"Phenylalanine metabolism";"Isoquinoline alkaloid biosynthesis";"Tyrosine catabolism";"Ubiquinone and other terpenoid-quinone biosynthesis";"Tyrosine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis" lcl|NW_020311984.1_prot_XP_012254505.1_19946 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311988.1_prot_XP_012268189.1_20499 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" lcl|NW_020311321.1_prot_XP_012263245.1_3437 2 Reactome: R-HSA-3928665;Reactome: R-HSA-2682334 "EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling" lcl|NW_020311962.1_prot_XP_012252018.1_13805 2 Reactome: R-HSA-9603798;Reactome: R-HSA-1369062 "Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis" lcl|NW_020311962.1_prot_XP_020706672.1_13566 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311305.1_prot_XP_012264123.1_2004 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311982.1_prot_XP_025602858.1_19335 2 Reactome: R-HSA-201722;Reactome: R-HSA-3769402 "Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex" lcl|NW_020311401.1_prot_XP_012255060.1_7641 16 Reactome: R-HSA-8936459;Reactome: R-HSA-2559585;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-8934593;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-9029569;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Oncogene Induced Senescence";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"Regulation of RUNX1 Expression and Activity";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation" lcl|NW_020311285.1_prot_XP_012255879.1_12 1 KEGG: 00970+6.1.1.22 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311432.1_prot_XP_012268882.1_8314 11 Reactome: R-HSA-5668599;KEGG: 00562+2.7.1.137;MetaCyc: PWY-6352;KEGG: 04070+2.7.1.137;Reactome: R-HSA-1632852;Reactome: R-HSA-168138;Reactome: R-HSA-1660516;Reactome: R-HSA-1660499;Reactome: R-HSA-1660514;Reactome: R-HSA-1660517;Reactome: R-HSA-109704 "RHO GTPases Activate NADPH Oxidases";"Inositol phosphate metabolism";"3-phosphoinositide biosynthesis";"Phosphatidylinositol signaling system";"Macroautophagy";"Toll Like Receptor 9 (TLR9) Cascade";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the late endosome membrane";"PI3K Cascade" lcl|NW_020311971.1_prot_XP_025602664.1_15863 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311559.1_prot_XP_025602218.1_10045 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311917.1_prot_XP_020706424.1_10218 1 Reactome: R-HSA-9633012 "Response of EIF2AK4 (GCN2) to amino acid deficiency" lcl|NW_020311995.1_prot_XP_012256970.1_21946 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311433.1_prot_XP_020710704.1_8627 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311966.1_prot_XP_020707017.1_14536 9 MetaCyc: PWY-7902;KEGG: 00564+1.1.1.94;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-6118;MetaCyc: PWY-5667;KEGG: 00564+1.1.1.8;Reactome: R-HSA-1483166;MetaCyc: PWY-7385 "Glucosylglycerol biosynthesis";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Glycerol-3-phosphate shuttle";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PA";"1,3-propanediol biosynthesis (engineered)" lcl|NW_020311940.1_prot_XP_020711282.1_11214 7 MetaCyc: PWY-5941;MetaCyc: PWY-6737;KEGG: 00500+2.4.1.25;Reactome: R-HSA-6798695;MetaCyc: PWY-6724;MetaCyc: PWY-7238;Reactome: R-HSA-70221 "Glycogen degradation II";"Starch degradation V";"Starch and sucrose metabolism";"Neutrophil degranulation";"Starch degradation II";"Sucrose biosynthesis II";"Glycogen breakdown (glycogenolysis)" lcl|NW_020311299.1_prot_XP_012263170.1_1438 3 Reactome: R-HSA-114608;Reactome: R-HSA-195399;Reactome: R-HSA-194313 "Platelet degranulation";"VEGF binds to VEGFR leading to receptor dimerization";"VEGF ligand-receptor interactions" lcl|NW_020311373.1_prot_XP_020711641.1_6459 8 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Signaling by Hippo";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway" lcl|NW_020311940.1_prot_XP_012265623.1_11285 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311956.1_prot_XP_020706565.1_12639 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311513.1_prot_XP_012266001.1_9904 1 Reactome: R-HSA-1483255 "PI Metabolism" lcl|NW_020311411.1_prot_XP_012256350.1_7855 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311971.1_prot_XP_020710498.1_16125 2 Reactome: R-HSA-190873;Reactome: R-HSA-399719 "Gap junction degradation";"Trafficking of AMPA receptors" lcl|NW_020311961.1_prot_XP_012262699.1_13471 57 Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-174084;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-6798695;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-174113;Reactome: R-HSA-202424 "Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RAS by GAPs";"G2/M Checkpoints";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Neutrophil degranulation";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling" lcl|NW_020311974.1_prot_XP_012260158.1_16766 1 MetaCyc: PWY-6829 "Trna methylation (yeast)" lcl|NW_020311971.1_prot_XP_012263517.1_16099 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311964.1_prot_XP_012261996.1_13951 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311960.1_prot_XP_012255464.1_13227 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311313.1_prot_XP_020709959.1_2841 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311995.1_prot_XP_020708166.1_22103 5 Reactome: R-HSA-8854214;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-165181 "TBC/RABGAPs";"Macroautophagy";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Inhibition of TSC complex formation by PKB" lcl|NW_020311946.1_prot_XP_012268645.1_11923 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311950.1_prot_XP_012250673.1_12182 1 Reactome: R-HSA-8876725 "Protein methylation" lcl|NW_020311311.1_prot_XP_012250805.1_2493 1 KEGG: 00900+3.4.24.84 "Terpenoid backbone biosynthesis" lcl|NW_020311976.1_prot_XP_012253661.2_17282 2 Reactome: R-HSA-6783310;Reactome: R-HSA-5693568 "Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311318.1_prot_XP_012253499.1_3311 14 KEGG: 00562+3.1.4.11;Reactome: R-HSA-4086398;MetaCyc: PWY-7039;Reactome: R-HSA-500657;Reactome: R-HSA-112043;Reactome: R-HSA-1855204;Reactome: R-HSA-399997;KEGG: 04070+3.1.4.11;Reactome: R-HSA-416476;Reactome: R-HSA-418217;MetaCyc: PWY-6367;Reactome: R-HSA-434316;MetaCyc: PWY-6351;MetaCyc: PWY-8052 "Inositol phosphate metabolism";"Ca2+ pathway";"Phosphatidate metabolism, as a signaling molecule";"Presynaptic function of Kainate receptors";"PLC beta mediated events";"Synthesis of IP3 and IP4 in the cytosol";"Acetylcholine regulates insulin secretion";"Phosphatidylinositol signaling system";"G alpha (q) signalling events";"G beta:gamma signalling through PLC beta";"D-myo-inositol-5-phosphate metabolism";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"2-arachidonoylglycerol biosynthesis" lcl|NW_020311372.1_prot_XP_012268449.1_6387 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311304.1_prot_XP_012261402.1_1894 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311966.1_prot_XP_012256327.1_14928 4 Reactome: R-HSA-167160;MetaCyc: PWY-7375;Reactome: R-HSA-77075;Reactome: R-HSA-72086 "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Mrna capping I";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping" lcl|NW_020311961.1_prot_XP_012262688.1_13362 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311957.1_prot_XP_012262118.1_12729 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311970.1_prot_XP_012267574.1_15790 2 KEGG: 00970+6.1.1.4;Reactome: R-HSA-379726 "Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" lcl|NW_020311974.1_prot_XP_012260110.1_16864 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311332.1_prot_XP_012256533.1_4194 14 MetaCyc: PWY-8055;MetaCyc: PWY-8053;Reactome: R-HSA-4419969;KEGG: 00600+3.1.3.4;Reactome: R-HSA-1483213;KEGG: 00561+3.1.3.4;KEGG: 00564+3.1.3.4;MetaCyc: PWY-8052;Reactome: R-HSA-75109;MetaCyc: PWY-8051;MetaCyc: PWY-6453;Reactome: R-HSA-1483191;KEGG: 00565+3.1.3.4;MetaCyc: PWY-7782 "Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"Depolymerisation of the Nuclear Lamina";"Sphingolipid metabolism";"Synthesis of PE";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"2-arachidonoylglycerol biosynthesis";"Triglyceride biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Synthesis of PC";"Ether lipid metabolism";"Plasmalogen biosynthesis" lcl|NW_020311302.1_prot_XP_012264540.1_1680 1 Reactome: R-HSA-2564830 "Cytosolic iron-sulfur cluster assembly" lcl|NW_020311977.1_prot_XP_012263755.1_17848 6 MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656 "Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311287.1_prot_XP_012268133.1_327 8 Reactome: R-HSA-9609690;Reactome: R-HSA-3214841;Reactome: R-HSA-2559580;Reactome: R-HSA-8953750;Reactome: R-HSA-4551638;Reactome: R-HSA-8943724;Reactome: R-HSA-212300;Reactome: R-HSA-5617472 "HCMV Early Events";"PKMTs methylate histone lysines";"Oxidative Stress Induced Senescence";"Transcriptional Regulation by E2F6";"SUMOylation of chromatin organization proteins";"Regulation of PTEN gene transcription";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis" lcl|NW_020311966.1_prot_XP_012256389.1_14946 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311971.1_prot_XP_025602669.1_15838 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311966.1_prot_XP_012257183.1_15074 7 Reactome: R-HSA-5628897;Reactome: R-HSA-8854214;Reactome: R-HSA-5674400;Reactome: R-HSA-1632852;Reactome: R-HSA-198323;Reactome: R-HSA-165181;Reactome: R-HSA-380972 "TP53 Regulates Metabolic Genes";"TBC/RABGAPs";"Constitutive Signaling by AKT1 E17K in Cancer";"Macroautophagy";"AKT phosphorylates targets in the cytosol";"Inhibition of TSC complex formation by PKB";"Energy dependent regulation of mTOR by LKB1-AMPK" lcl|NW_020311976.1_prot_XP_012253549.1_17271 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311945.1_prot_XP_012269659.1_11818 13 KEGG: 00670+6.3.4.3;MetaCyc: PWY-7909;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-2161;MetaCyc: PWY-2201;MetaCyc: PWY-6613;MetaCyc: PWY-5497;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;KEGG: 00720+6.3.4.3;MetaCyc: PWY-5030;Reactome: R-HSA-196757;MetaCyc: PWY-1722 "One carbon pool by folate";"Formaldehyde oxidation VII (THF pathway)";"One carbon pool by folate";"Folate polyglutamylation";"Folate transformations I";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine nucleobases degradation II (anaerobic)";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"L-histidine degradation III";"Metabolism of folate and pterines";"Formate assimilation into 5,10-methylenetetrahydrofolate" lcl|NW_020311977.1_prot_XP_020710693.1_17886 6 MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782 "Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311358.1_prot_XP_012255854.1_5659 1 Reactome: R-HSA-201681 "TCF dependent signaling in response to WNT" lcl|NW_020311305.1_prot_XP_012263685.1_1992 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311970.1_prot_XP_012269094.1_15614 4 Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825 "DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311365.1_prot_XP_012269338.1_5999 4 Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" lcl|NW_020311407.1_prot_XP_012254813.1_7756 2 Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" lcl|NW_020311956.1_prot_XP_012251383.1_12622 1 Reactome: R-HSA-162658 "Golgi Cisternae Pericentriolar Stack Reorganization" lcl|NW_020311983.1_prot_XP_020711799.1_19476 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311972.1_prot_XP_020710811.1_16303 7 Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-156711 "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"Polo-like kinase mediated events" lcl|NW_020311988.1_prot_XP_020709722.1_20735 14 MetaCyc: PWY-6598;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-7725;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-5972;MetaCyc: PWY-7619;MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-7036;KEGG: 00062+2.3.1.199 "Sciadonate biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation" lcl|NW_020311974.1_prot_XP_012260117.1_16869 1 Reactome: R-HSA-446210 "Synthesis of UDP-N-acetyl-glucosamine" lcl|NW_020311413.1_prot_XP_012254381.1_7912 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311995.1_prot_XP_012256285.1_21996 6 Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-72702 "Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition" lcl|NW_020311979.1_prot_XP_012259574.1_18629 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection" lcl|NW_020311965.1_prot_XP_012260178.1_14108 1 Reactome: R-HSA-8943724 "Regulation of PTEN gene transcription" lcl|NW_020311987.1_prot_XP_012269491.1_20369 15 Reactome: R-HSA-141430;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-174048;Reactome: R-HSA-174154;Reactome: R-HSA-2559582;Reactome: R-HSA-174084;Reactome: R-HSA-8853884;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-179409;Reactome: R-HSA-176407;Reactome: R-HSA-176408 "Inactivation of APC/C via direct inhibition of the APC/C complex";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC/C:Cdc20 mediated degradation of Securin";"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Transcriptional Regulation by VENTX";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC-Cdc20 mediated degradation of Nek2A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Regulation of APC/C activators between G1/S and early anaphase" lcl|NW_020311976.1_prot_XP_012257187.1_17375 2 Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" lcl|NW_020311312.1_prot_XP_012266770.1_2773 1 Reactome: R-HSA-381038 "XBP1(S) activates chaperone genes" lcl|NW_020311383.1_prot_XP_012251548.1_6882 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311299.1_prot_XP_012263253.1_1422 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311981.1_prot_XP_012257480.1_19039 11 Reactome: R-HSA-9013700;Reactome: R-HSA-2894862;Reactome: R-HSA-205043;Reactome: R-HSA-2644606;Reactome: R-HSA-193692;Reactome: R-HSA-3928665;Reactome: R-HSA-1251985;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-9017802 "NOTCH4 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NRIF signals cell death from the nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulated proteolysis of p75NTR";"EPH-ephrin mediated repulsion of cells";"Nuclear signaling by ERBB4";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Noncanonical activation of NOTCH3" lcl|NW_020311984.1_prot_XP_025602884.1_20142 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311299.1_prot_XP_012263260.1_1442 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311985.1_prot_XP_012253903.1_20288 11 Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-75955 "Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation" lcl|NW_020311975.1_prot_XP_012269802.1_17009 14 MetaCyc: PWY-8055;MetaCyc: PWY-8053;MetaCyc: PWY-7589;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7417;MetaCyc: PWY-6453;MetaCyc: PWY-5667;MetaCyc: PWY-7587;Reactome: R-HSA-1483166;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7782 "Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Synthesis of PA";"Glycerolipid metabolism";"Plasmalogen biosynthesis" lcl|NW_020311298.1_prot_XP_012269933.1_1260 4 Reactome: R-HSA-400511;Reactome: R-HSA-1799339;Reactome: R-HSA-422085;Reactome: R-HSA-381771 "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)" lcl|NW_020311991.1_prot_XP_012269792.1_20938 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311956.1_prot_XP_012251358.1_12631 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311992.1_prot_XP_012266434.1_21219 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311983.1_prot_XP_012255543.1_19746 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311984.1_prot_XP_012267728.1_20130 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311298.1_prot_XP_020706289.1_1270 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311977.1_prot_XP_012264057.1_17677 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311511.1_prot_XP_012250944.1_9670 2 Reactome: R-HSA-8873719;Reactome: R-HSA-6803205 "RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" lcl|NW_020311976.1_prot_XP_012257869.1_17453 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311290.1_prot_XP_012267511.1_433 5 Reactome: R-HSA-964975;Reactome: R-HSA-6798695;MetaCyc: PWY-7282;MetaCyc: PWY-7204;KEGG: 00750+2.7.1.35 "Vitamins B6 activation to pyridoxal phosphate";"Neutrophil degranulation";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Pyridoxal 5'-phosphate salvage II (plants)";"Vitamin B6 metabolism" lcl|NW_020311439.1_prot_XP_012264167.1_8834 1 Reactome: R-HSA-2465910 "MASTL Facilitates Mitotic Progression" lcl|NW_020311974.1_prot_XP_012260001.1_16644 6 Reactome: R-HSA-210500;Reactome: R-HSA-181430;Reactome: R-HSA-181429;Reactome: R-HSA-388844;Reactome: R-HSA-264642;Reactome: R-HSA-212676 "Glutamate Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle" lcl|NW_020311970.1_prot_XP_012269056.1_15680 3 Reactome: R-HSA-72165;Reactome: R-HSA-430039;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway" lcl|NW_020311365.1_prot_XP_012269356.1_6015 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" lcl|NW_020311978.1_prot_XP_012257766.1_18195 42 Reactome: R-HSA-1221632;Reactome: R-HSA-4551638;Reactome: R-HSA-73728;Reactome: R-HSA-212300;Reactome: R-HSA-9609690;Reactome: R-HSA-9616222;Reactome: R-HSA-3214841;Reactome: R-HSA-427389;Reactome: R-HSA-427413;Reactome: R-HSA-5693571;Reactome: R-HSA-912446;Reactome: R-HSA-110331;Reactome: R-HSA-110328;Reactome: R-HSA-110330;Reactome: R-HSA-3214858;Reactome: R-HSA-8939236;Reactome: R-HSA-427359;Reactome: R-HSA-9018519;Reactome: R-HSA-2559582;Reactome: R-HSA-171306;Reactome: R-HSA-69473;Reactome: R-HSA-8936459;Reactome: R-HSA-5578749;Reactome: R-HSA-3214842;Reactome: R-HSA-977225;Reactome: R-HSA-5693565;Reactome: R-HSA-5625886;Reactome: R-HSA-5617472;Reactome: R-HSA-2559586;Reactome: R-HSA-5250924;Reactome: R-HSA-5693607;Reactome: R-HSA-2299718;Reactome: R-HSA-201722;Reactome: R-HSA-1912408;Reactome: R-HSA-110329;Reactome: R-HSA-5334118;Reactome: R-HSA-73772;Reactome: R-HSA-606279;Reactome: R-HSA-3214847;Reactome: R-HSA-3214815;Reactome: R-HSA-9610379;Reactome: R-HSA-2559580 "Meiotic synapsis";"SUMOylation of chromatin organization proteins";"RNA Polymerase I Promoter Opening";"PRC2 methylates histones and DNA";"HCMV Early Events";"Transcriptional regulation of granulopoiesis";"PKMTs methylate histone lysines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"NoRC negatively regulates rRNA expression";"Nonhomologous End-Joining (NHEJ)";"Meiotic recombination";"Cleavage of the damaged purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected purine";"RMTs methylate histone arginines";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"SIRT1 negatively regulates rRNA expression";"Estrogen-dependent gene expression";"Senescence-Associated Secretory Phenotype (SASP)";"Packaging Of Telomere Ends";"G2/M DNA damage checkpoint";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional regulation by small RNAs";"HDMs demethylate histones";"Amyloid fiber formation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"DNA Damage/Telomere Stress Induced Senescence";"B-WICH complex positively regulates rRNA expression";"Processing of DNA double-strand break ends";"Condensation of Prophase Chromosomes";"Formation of the beta-catenin:TCF transactivating complex";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged pyrimidine";"DNA methylation";"RNA Polymerase I Promoter Escape";"Deposition of new CENPA-containing nucleosomes at the centromere";"HATs acetylate histones";"HDACs deacetylate histones";"HCMV Late Events";"Oxidative Stress Induced Senescence" lcl|NW_020311984.1_prot_XP_012254496.1_19921 12 KEGG: 00052+2.7.7.9;MetaCyc: PWY-3801;KEGG: 00500+2.7.7.9;KEGG: 00040+2.7.7.9;MetaCyc: PWY-7343;MetaCyc: PWY-6527;Reactome: R-HSA-173599;Reactome: R-HSA-3322077;KEGG: 00520+2.7.7.9;MetaCyc: PWY-7817;MetaCyc: PWY-7238;KEGG: 00561+2.7.7.9 "Galactose metabolism";"Sucrose degradation II (sucrose synthase)";"Starch and sucrose metabolism";"Pentose and glucuronate interconversions";"UDP-alpha-D-glucose biosynthesis I";"Stachyose degradation";"Formation of the active cofactor, UDP-glucuronate";"Glycogen synthesis";"Amino sugar and nucleotide sugar metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Sucrose biosynthesis II";"Glycerolipid metabolism" lcl|NW_020311976.1_prot_XP_012253630.1_17323 2 Reactome: R-HSA-8876198;Reactome: R-HSA-204005 "RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport" lcl|NW_020311365.1_prot_XP_012269439.1_6028 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311983.1_prot_XP_012255537.1_19645 15 Reactome: R-HSA-5685942;Reactome: R-HSA-5685939;Reactome: R-HSA-5685938;Reactome: R-HSA-2559586;Reactome: R-HSA-5693571;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-69473;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-5693548;Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554 "HDR through Homologous Recombination (HRR)";"HDR through MMEJ (alt-NHEJ)";"HDR through Single Strand Annealing (SSA)";"DNA Damage/Telomere Stress Induced Senescence";"Nonhomologous End-Joining (NHEJ)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"G2/M DNA damage checkpoint";"Meiotic recombination";"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"Sensing of DNA Double Strand Breaks";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" lcl|NW_020311988.1_prot_XP_012269577.1_20594 5 Reactome: R-HSA-3249367;Reactome: R-HSA-1834941;Reactome: R-HSA-6798695;Reactome: R-HSA-3270619;Reactome: R-HSA-3134975 "STAT6-mediated induction of chemokines";"STING mediated induction of host immune responses";"Neutrophil degranulation";"IRF3-mediated induction of type I IFN";"Regulation of innate immune responses to cytosolic DNA" lcl|NW_020311289.1_prot_XP_012253811.1_381 5 Reactome: R-HSA-390471;Reactome: R-HSA-6814122;Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390450 "Association of TriC/CCT with target proteins during biosynthesis";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC" lcl|NW_020311940.1_prot_XP_012265586.1_11220 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311308.1_prot_XP_020710852.1_2171 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" lcl|NW_020311373.1_prot_XP_020710377.1_6405 1 Reactome: R-HSA-111957 "Cam-PDE 1 activation" lcl|NW_020311955.1_prot_XP_012265384.1_12412 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" lcl|NW_020311961.1_prot_XP_012262551.1_13522 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311298.1_prot_XP_012269899.1_1233 5 KEGG: 00052+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00561+3.2.1.22 "Galactose metabolism";"Stachyose degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycerolipid metabolism" lcl|NW_020311966.1_prot_XP_012257239.1_15079 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311977.1_prot_XP_012263908.1_17732 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311964.1_prot_XP_012261960.1_13877 5 KEGG: 04070+2.7.7.41;MetaCyc: PWY-7817;MetaCyc: PWY-5667;KEGG: 00564+2.7.7.41;MetaCyc: PWY-5981 "Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III" lcl|NW_020311955.1_prot_XP_012265434.1_12347 3 Reactome: R-HSA-3299685;Reactome: R-HSA-5628897;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"TP53 Regulates Metabolic Genes";"Glutathione metabolism" lcl|NW_020311934.1_prot_XP_012255133.1_10808 2 KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386 "Pyruvate metabolism";"Methylglyoxal degradation I" lcl|NW_020311972.1_prot_XP_012267847.1_16249 2 Reactome: R-HSA-8873719;Reactome: R-HSA-8876198 "RAB geranylgeranylation";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311312.1_prot_XP_012266929.1_2728 6 Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-111367;Reactome: R-HSA-191859;Reactome: R-HSA-72165;Reactome: R-HSA-77588 "mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"SLBP independent Processing of Histone Pre-mRNAs";"snRNP Assembly";"mRNA Splicing - Minor Pathway";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" lcl|NW_020311983.1_prot_XP_012267224.1_19497 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" lcl|NW_020311299.1_prot_XP_012263179.1_1478 1 KEGG: 00970+6.1.1.21 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311401.1_prot_XP_012255265.1_7507 5 Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-427413 "RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression" lcl|NW_020311970.1_prot_NP_001295473.1_15775 13 Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689 "Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits" lcl|NW_020311418.1_prot_XP_012261085.1_7969 2 Reactome: R-HSA-4641262;Reactome: R-HSA-196299 "Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Beta-catenin phosphorylation cascade" lcl|NW_020311432.1_prot_XP_012268937.1_8401 1 Reactome: R-HSA-8850843 "Phosphate bond hydrolysis by NTPDase proteins" lcl|NW_020311976.1_prot_XP_012257428.1_17360 6 Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450513 "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" lcl|NW_020311934.1_prot_XP_012255339.1_10857 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311961.1_prot_XP_012262531.1_13263 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311983.1_prot_XP_012255592.1_19666 2 Reactome: R-HSA-2142691;Reactome: R-HSA-2142700 "Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)" lcl|NW_020311298.1_prot_XP_012269949.1_1187 3 MetaCyc: PWY-6619;Reactome: R-HSA-74217;KEGG: 00230+2.7.1.20 "Adenine and adenosine salvage VI";"Purine salvage";"Purine metabolism" lcl|NW_020311977.1_prot_XP_012263903.1_17714 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311977.1_prot_XP_020710549.1_17880 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311966.1_prot_XP_012256399.1_14945 2 Reactome: R-HSA-5205685;Reactome: R-HSA-1268020 "Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import" lcl|NW_020311305.1_prot_XP_012263660.1_1967 1 Reactome: R-HSA-6787450 "tRNA modification in the mitochondrion" lcl|NW_020311309.1_prot_XP_012259147.1_2346 5 Reactome: R-HSA-68827;Reactome: R-HSA-69205;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68867 "CDT1 association with the CDC6:ORC:origin complex";"G1/S-Specific Transcription";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex" lcl|NW_020311974.1_prot_XP_012260109.1_16863 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311326.1_prot_XP_012261530.1_3730 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311965.1_prot_XP_012259977.1_14220 5 Reactome: R-HSA-4793954;Reactome: R-HSA-532668;MetaCyc: PWY-7918;KEGG: 00510+3.2.1.106;MetaCyc: PWY-7919 "Defective MOGS causes MOGS-CDG (CDG-2b)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Protein N-glycosylation processing phase (yeast)";"N-Glycan biosynthesis";"Protein N-glycosylation processing phase (plants and animals)" lcl|NW_020311374.1_prot_XP_012264385.1_6532 2 Reactome: R-HSA-983168;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation" lcl|NW_020311988.1_prot_XP_012267964.1_20547 7 MetaCyc: PWY-7854;MetaCyc: PWY-6969;MetaCyc: PWY-7295;KEGG: 00630+2.3.3.9;MetaCyc: PWY-7294;MetaCyc: PWY-7118;KEGG: 00620+2.3.3.9 "Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"L-arabinose degradation IV";"Glyoxylate and dicarboxylate metabolism";"D-xylose degradation IV";"Chitin degradation to ethanol";"Pyruvate metabolism" lcl|NW_020311934.1_prot_XP_020707809.1_10856 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311290.1_prot_XP_012267421.1_434 5 Reactome: R-HSA-964975;MetaCyc: PWY-7282;Reactome: R-HSA-6798695;KEGG: 00750+2.7.1.35;MetaCyc: PWY-7204 "Vitamins B6 activation to pyridoxal phosphate";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Neutrophil degranulation";"Vitamin B6 metabolism";"Pyridoxal 5'-phosphate salvage II (plants)" lcl|NW_020311991.1_prot_XP_012269738.1_20921 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311966.1_prot_XP_012256509.1_14756 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311978.1_prot_XP_025602788.1_18342 13 MetaCyc: PWY-5537;MetaCyc: PWY-7384;Reactome: R-HSA-71403;MetaCyc: PWY-6969;MetaCyc: PWY-5538;MetaCyc: PWY-5913;KEGG: 00020+6.2.1.5;KEGG: 00640+6.2.1.5;KEGG: 00660+6.2.1.5;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-6728;MetaCyc: PWY-5690 "Pyruvate fermentation to acetate V";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citric acid cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Methylaspartate cycle";"TCA cycle II (plants and fungi)" lcl|NW_020311988.1_prot_XP_012253568.1_20556 1 Reactome: R-HSA-6790901 "rRNA modification in the nucleus and cytosol" lcl|NW_020311423.1_prot_XP_012251578.1_8157 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311970.1_prot_XP_012260237.1_15606 33 Reactome: R-HSA-3301854;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-2500257;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-2467813;Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-168325;Reactome: R-HSA-170822;Reactome: R-HSA-159230;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-168276;Reactome: R-HSA-68877;Reactome: R-HSA-6784531;Reactome: R-HSA-4551638;Reactome: R-HSA-180910;Reactome: R-HSA-9648025;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-4085377 "Nuclear Pore Complex (NPC) Disassembly";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Resolution of Sister Chromatid Cohesion";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transcriptional regulation by small RNAs";"snRNP Assembly";"SUMOylation of DNA replication proteins";"Separation of Sister Chromatids";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"Viral Messenger RNA Synthesis";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP Dependant Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"NS1 Mediated Effects on Host Pathways";"Mitotic Prometaphase";"tRNA processing in the nucleus";"SUMOylation of chromatin organization proteins";"Vpr-mediated nuclear import of PICs";"EML4 and NUDC in mitotic spindle formation";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"HCMV Early Events";"RHO GTPases Activate Formins";"SUMOylation of SUMOylation proteins" lcl|NW_020311918.1_prot_XP_012269456.1_10277 2 Reactome: R-HSA-5689880;Reactome: R-HSA-3214847 "Ub-specific processing proteases";"HATs acetylate histones" lcl|NW_020311308.1_prot_XP_020710834.1_2177 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311383.1_prot_XP_012251552.1_6887 3 Reactome: R-HSA-189451;KEGG: 00860+2.5.1.141;MetaCyc: PWY-7856 "Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"Heme a biosynthesis" lcl|NW_020311993.1_prot_XP_012268383.1_21474 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311994.1_prot_XP_012267495.1_21539 2 Reactome: R-HSA-877300;Reactome: R-HSA-2132295 "Interferon gamma signaling";"MHC class II antigen presentation" lcl|NW_020311940.1_prot_XP_020711226.1_11186 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311318.1_prot_XP_012253380.1_3277 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311401.1_prot_XP_012255353.1_7544 2 Reactome: R-HSA-6798695;Reactome: R-HSA-1799339 "Neutrophil degranulation";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311975.1_prot_XP_012251175.1_17086 10 MetaCyc: PWY-7198;Reactome: R-HSA-69205;MetaCyc: PWY-7210;MetaCyc: PWY-7187;MetaCyc: PWY-7199;Reactome: R-HSA-499943;KEGG: 00240+2.1.1.45;KEGG: 00670+2.1.1.45;MetaCyc: PWY-7184;MetaCyc: PWY-3841 "Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"G1/S-Specific Transcription";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleosides salvage";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine metabolism";"One carbon pool by folate";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Folate transformations II (plants)" lcl|NW_020311994.1_prot_XP_012267463.1_21790 2 Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7 "Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311973.1_prot_XP_012258665.1_16586 3 Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340 "PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311937.1_prot_XP_012252638.1_11037 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" lcl|NW_020311333.1_prot_XP_012255950.1_4259 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311320.1_prot_XP_012259281.1_3351 2 Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13 "Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system" lcl|NW_020311304.1_prot_XP_012259554.1_1881 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311469.1_prot_XP_012266616.1_9296 1 Reactome: R-HSA-2028269 "Signaling by Hippo" lcl|NW_020311526.1_prot_XP_012269452.1_9947 4 MetaCyc: PWY-801;Reactome: R-HSA-1614603;KEGG: 00260+4.2.1.22;KEGG: 00270+4.2.1.22 "Homocysteine and cysteine interconversion";"Cysteine formation from homocysteine";"Glycine, serine and threonine metabolism";"Cysteine and methionine metabolism" lcl|NW_020311992.1_prot_XP_012266318.1_21229 8 Reactome: R-HSA-5620912;Reactome: R-HSA-6804115;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Anchoring of the basal body to the plasma membrane";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311364.1_prot_XP_012258903.1_5900 6 KEGG: 00520+1.1.1.22;MetaCyc: PWY-7820;Reactome: R-HSA-173599;KEGG: 00040+1.1.1.22;KEGG: 00053+1.1.1.22;MetaCyc: PWY-7346 "Amino sugar and nucleotide sugar metabolism";"Teichuronic acid biosynthesis (B. subtilis 168)";"Formation of the active cofactor, UDP-glucuronate";"Pentose and glucuronate interconversions";"Ascorbate and aldarate metabolism";"UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)" lcl|NW_020311964.1_prot_NP_001295475.1_13914 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311317.1_prot_XP_020706639.1_3262 3 Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878 "Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport" lcl|NW_020311991.1_prot_XP_012269772.1_20876 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311286.1_prot_XP_012256852.1_58 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311990.1_prot_XP_012266955.2_20820 16 Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012 "Translation initiation complex formation";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency" lcl|NW_020311456.1_prot_XP_012255830.1_9113 2 Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" lcl|NW_020311943.1_prot_XP_012255182.1_11566 7 Reactome: R-HSA-606279;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877 "Deposition of new CENPA-containing nucleosomes at the centromere";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase" lcl|NW_020311352.1_prot_XP_025601832.1_5384 4 Reactome: R-HSA-2214320;Reactome: R-HSA-1650814;Reactome: R-HSA-1474228;Reactome: R-HSA-2243919 "Anchoring fibril formation";"Collagen biosynthesis and modifying enzymes";"Degradation of the extracellular matrix";"Crosslinking of collagen fibrils" lcl|NW_020311424.1_prot_XP_012255428.1_8235 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311992.1_prot_XP_012266286.1_21028 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311309.1_prot_XP_020709062.1_2366 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311380.1_prot_XP_012268210.1_6713 8 Reactome: R-HSA-5099900;Reactome: R-HSA-432720;Reactome: R-HSA-8856825;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828;Reactome: R-HSA-5140745;Reactome: R-HSA-196025;Reactome: R-HSA-190873 "WNT5A-dependent internalization of FZD4";"Lysosome Vesicle Biogenesis";"Cargo recognition for clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Formation of annular gap junctions";"Gap junction degradation" lcl|NW_020311983.1_prot_XP_012267209.1_19488 3 Reactome: R-HSA-1358803;MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Downregulation of ERBB2:ERBB3 signaling";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311294.1_prot_XP_020711019.1_866 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" lcl|NW_020311439.1_prot_XP_020710763.1_8847 2 Reactome: R-HSA-400253;Reactome: R-HSA-2151201 "Circadian Clock";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311309.1_prot_XP_020709063.1_2367 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311286.1_prot_XP_012256564.1_161 7 MetaCyc: PWY-6922;MetaCyc: PWY-31;Reactome: R-HSA-70635;MetaCyc: PWY-4984;KEGG: 00220+3.5.3.1;KEGG: 00330+3.5.3.1;MetaCyc: PWY-46 "L-Ndelta-acetylornithine biosynthesis";"Canavanine degradation";"Urea cycle";"Urea cycle";"Arginine biosynthesis";"Arginine and proline metabolism";"Putrescine biosynthesis III" lcl|NW_020311993.1_prot_XP_012263300.1_21376 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" lcl|NW_020311432.1_prot_XP_012268707.1_8462 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311943.1_prot_XP_020707698.1_11651 5 MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;Reactome: R-HSA-189085 "Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Digestion of dietary carbohydrate" lcl|NW_020311441.1_prot_XP_012251259.1_8859 3 Reactome: R-HSA-70268;KEGG: 00620+4.4.1.5;MetaCyc: PWY-5386 "Pyruvate metabolism";"Pyruvate metabolism";"Methylglyoxal degradation I" lcl|NW_020311992.1_prot_XP_012266469.1_21290 1 Reactome: R-HSA-70895 "Branched-chain amino acid catabolism" lcl|NW_020311391.1_prot_XP_012256737.1_7026 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311407.1_prot_XP_020707770.1_7771 20 MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7337;MetaCyc: PWY-7291;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7858;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-6920;MetaCyc: PWY-7288;MetaCyc: PWY-7007;Reactome: R-HSA-9033241;MetaCyc: PWY-735;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7574;MetaCyc: PWY-7854;MetaCyc: PWY-7606 "Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"alpha-Linolenic acid metabolism";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"beta-Alanine metabolism";"(5Z)-dodecenoate biosynthesis II";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Methyl ketone biosynthesis (engineered)";"Peroxisomal protein import";"Jasmonic acid biosynthesis";"Propanoate metabolism";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoyl-coa degradation II";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)" lcl|NW_020311968.1_prot_XP_012253067.1_15436 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311978.1_prot_XP_012258047.1_18290 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311976.1_prot_XP_012253445.1_17265 1 Reactome: R-HSA-5689896 "Ovarian tumor domain proteases" lcl|NW_020311975.1_prot_XP_012254206.1_16994 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311961.1_prot_XP_012262698.1_13540 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311973.1_prot_XP_012258819.1_16627 2 KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261 "Glycerolipid metabolism";"Glycerol degradation I" lcl|NW_020311377.1_prot_XP_012266630.1_6613 2 Reactome: R-HSA-399719;Reactome: R-HSA-190873 "Trafficking of AMPA receptors";"Gap junction degradation" lcl|NW_020311985.1_prot_XP_012265216.1_20262 6 MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656 "Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311979.1_prot_XP_012259507.1_18532 3 Reactome: R-HSA-5358493;MetaCyc: PWY-7546;MetaCyc: PWY-6482 "Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)" lcl|NW_020311975.1_prot_XP_012253200.1_16970 4 Reactome: R-HSA-196108;Reactome: R-HSA-2395516;Reactome: R-HSA-5579026;Reactome: R-HSA-211976 "Pregnenolone biosynthesis";"Electron transport from NADPH to Ferredoxin";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Endogenous sterols" lcl|NW_020311936.1_prot_XP_012261240.1_10984 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" lcl|NW_020311958.1_prot_XP_012255545.1_12928 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311932.1_prot_XP_012257427.1_10728 1 Reactome: R-HSA-611105 "Respiratory electron transport" lcl|NW_020311940.1_prot_XP_012252793.1_11141 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" lcl|NW_020311953.1_prot_XP_025602414.1_12232 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311966.1_prot_XP_012257114.1_14897 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311957.1_prot_XP_012263296.1_12831 13 Reactome: R-HSA-2160916;MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;Reactome: R-HSA-2022857;MetaCyc: PWY-6902;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-1660662 "Hyaluronan uptake and degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series";"Chitin degradation III (Serratia)";"CS/DS degradation";"Keratan sulfate degradation";"Chitin degradation II (Vibrio)";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Various types of N-glycan biosynthesis";"Glycosphingolipid metabolism" lcl|NW_020311434.1_prot_XP_020706764.1_8737 3 Reactome: R-HSA-1483191;Reactome: R-HSA-112311;Reactome: R-HSA-422085 "Synthesis of PC";"Neurotransmitter clearance";"Synthesis, secretion, and deacylation of Ghrelin" lcl|NW_020311976.1_prot_XP_012257651.1_17391 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311975.1_prot_XP_012252830.1_17076 5 Reactome: R-HSA-1912408;Reactome: R-HSA-1912420;Reactome: R-HSA-1912399;Reactome: R-HSA-350054;Reactome: R-HSA-5083630 "Pre-NOTCH Transcription and Translation";"Pre-NOTCH Processing in Golgi";"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Notch-HLH transcription pathway";"Defective LFNG causes SCDO3" lcl|NW_020311977.1_prot_XP_012263927.1_17863 16 Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits" lcl|NW_020311954.1_prot_XP_012268176.1_12340 3 MetaCyc: PWY-6689;Reactome: R-HSA-6784531;MetaCyc: PWY-7803 "Trna splicing I";"tRNA processing in the nucleus";"Trna splicing II" lcl|NW_020311312.1_prot_XP_012266772.1_2675 13 Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689 "Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits" lcl|NW_020311966.1_prot_XP_025602593.1_14481 2 Reactome: R-HSA-5620924;Reactome: R-HSA-5610787 "Intraflagellar transport";"Hedgehog 'off' state" lcl|NW_020311978.1_prot_XP_012257803.1_18277 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311942.1_prot_XP_012252449.1_11461 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" lcl|NW_020311292.1_prot_XP_020710266.1_692 4 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-419037 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"NCAM1 interactions" lcl|NW_020311920.1_prot_XP_025602269.1_10501 5 Reactome: R-HSA-5696397;Reactome: R-HSA-5649702;Reactome: R-HSA-6782210;Reactome: R-HSA-110381;Reactome: R-HSA-5685939 "Gap-filling DNA repair synthesis and ligation in GG-NER";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Resolution of AP sites via the single-nucleotide replacement pathway";"HDR through MMEJ (alt-NHEJ)" lcl|NW_020311976.1_prot_XP_020708431.1_17344 5 MetaCyc: PWY-7921;MetaCyc: PWY-7979;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;KEGG: 00515+2.4.1.109 "Protein O-mannosylation I (yeast)";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Mannose type O-glycan biosynthesis" lcl|NW_020311978.1_prot_XP_020708697.1_18367 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" lcl|NW_020311977.1_prot_XP_020710544.1_17770 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311939.1_prot_XP_012263556.1_11047 2 Reactome: R-HSA-1268020;Reactome: R-HSA-1482798 "Mitochondrial protein import";"Acyl chain remodeling of CL" lcl|NW_020311977.1_prot_XP_012264042.1_17610 3 Reactome: R-HSA-174403;KEGG: 00480+4.3.2.7;MetaCyc: PWY-7942 "Glutathione synthesis and recycling";"Glutathione metabolism";"5-oxo-L-proline metabolism" lcl|NW_020311976.1_prot_XP_012257672.1_17388 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311948.1_prot_XP_020707260.1_12017 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" lcl|NW_020311441.1_prot_XP_012251196.1_8907 4 KEGG: 00970+6.1.1.6;Reactome: R-HSA-379726;Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" lcl|NW_020311286.1_prot_XP_012257036.1_134 9 KEGG: 00620+6.4.1.1;Reactome: R-HSA-196780;MetaCyc: PWY-6146;Reactome: R-HSA-70263;KEGG: 00720+6.4.1.1;MetaCyc: PWY-6142;KEGG: 00020+6.4.1.1;MetaCyc: PWY-8086;Reactome: R-HSA-3371599 "Pyruvate metabolism";"Biotin transport and metabolism";"Methanobacterium thermoautotrophicum biosynthetic metabolism";"Gluconeogenesis";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Citrate cycle (TCA cycle)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Defective HLCS causes multiple carboxylase deficiency" lcl|NW_020311401.1_prot_XP_012255087.2_7440 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311973.1_prot_XP_012258799.1_16549 16 Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9633012 "Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency" lcl|NW_020311397.1_prot_XP_012253731.1_7347 3 Reactome: R-HSA-75109;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Triglyceride biosynthesis";"Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311977.1_prot_XP_012264106.1_18003 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311934.1_prot_XP_012254841.1_10871 1 Reactome: R-HSA-380972 "Energy dependent regulation of mTOR by LKB1-AMPK" lcl|NW_020311401.1_prot_XP_012255059.1_7640 16 Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-9018519;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459;Reactome: R-HSA-2559585;Reactome: R-HSA-8934593;Reactome: R-HSA-8943723 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"Estrogen-dependent gene expression";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Oncogene Induced Senescence";"Regulation of RUNX1 Expression and Activity";"Regulation of PTEN mRNA translation" lcl|NW_020311316.1_prot_XP_020712356.1_3155 7 MetaCyc: PWY-7219;MetaCyc: PWY-6124;MetaCyc: PWY-7234;KEGG: 00230+4.3.2.2;KEGG: 00250+4.3.2.2;MetaCyc: PWY-6123;Reactome: R-HSA-73817 "Adenosine ribonucleotides de novo biosynthesis";"Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis III";"Purine metabolism";"Alanine, aspartate and glutamate metabolism";"Inosine-5'-phosphate biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis" lcl|NW_020311983.1_prot_XP_020711793.1_19531 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311462.1_prot_XP_012252266.1_9214 4 Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-917977 "ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"Transferrin endocytosis and recycling" lcl|NW_020311413.1_prot_XP_020707534.1_7904 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311983.1_prot_XP_012267195.1_19482 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311308.1_prot_XP_012264418.1_2188 8 Reactome: R-HSA-5673001;Reactome: R-HSA-9609736;MetaCyc: PWY-7221;Reactome: R-HSA-9617324;KEGG: 00230+2.7.4.8;Reactome: R-HSA-442982;Reactome: R-HSA-438066;Reactome: R-HSA-9620244 "RAF/MAP kinase cascade";"Assembly and cell surface presentation of NMDA receptors";"Guanosine ribonucleotides de novo biosynthesis";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Purine metabolism";"Ras activation upon Ca2+ influx through NMDA receptor";"Unblocking of NMDA receptors, glutamate binding and activation";"Long-term potentiation" lcl|NW_020311359.1_prot_XP_012252060.1_5712 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311887.1_prot_XP_020711739.1_10127 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311513.1_prot_XP_020711417.1_9825 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311313.1_prot_XP_012261646.1_2934 2 Reactome: R-HSA-909733;Reactome: R-HSA-8983711 "Interferon alpha/beta signaling";"OAS antiviral response" lcl|NW_020311320.1_prot_XP_012259264.1_3347 6 Reactome: R-HSA-446210;MetaCyc: PWY-5514;KEGG: 00520+5.4.2.3;KEGG: 00520+5.4.2.10;MetaCyc: PWY-6906;MetaCyc: PWY-6749 "Synthesis of UDP-N-acetyl-glucosamine";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Amino sugar and nucleotide sugar metabolism";"Amino sugar and nucleotide sugar metabolism";"Chitin derivatives degradation";"CMP-legionaminate biosynthesis I" lcl|NW_020311977.1_prot_XP_012252235.1_17460 27 Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-159230;Reactome: R-HSA-168333;Reactome: R-HSA-5619107;Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-4570464;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-3301854;Reactome: R-HSA-159227;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-4615885;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-6784531;Reactome: R-HSA-4551638;Reactome: R-HSA-180910;Reactome: R-HSA-165054 "Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"Transport of the SLBP Dependant Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of RNA binding proteins";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"HCMV Early Events";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"SUMOylation of DNA replication proteins";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"tRNA processing in the nucleus";"SUMOylation of chromatin organization proteins";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA" lcl|NW_020311380.1_prot_XP_012261434.1_6682 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311943.1_prot_XP_012255079.1_11709 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311500.1_prot_XP_012260034.1_9581 56 Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5689880 "CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"G2/M Checkpoints";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Ub-specific processing proteases" lcl|NW_020311379.1_prot_XP_012261904.1_6651 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311983.1_prot_XP_012255534.1_19650 2 Reactome: R-HSA-71403;Reactome: R-HSA-611105 "Citric acid cycle (TCA cycle)";"Respiratory electron transport" lcl|NW_020311977.1_prot_XP_012253822.1_17581 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" lcl|NW_020311966.1_prot_XP_012256802.1_15193 4 MetaCyc: PWY-7887;Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+2.8.1.12 "Protein SAMPylation and SAMP-mediated thiolation";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis" lcl|NW_020311933.1_prot_XP_025602311.1_10763 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311441.1_prot_XP_012251268.1_8855 4 Reactome: R-HSA-189451;MetaCyc: PWY-5189;MetaCyc: PWY-5188;KEGG: 00860+2.5.1.61 "Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism" lcl|NW_020311357.1_prot_XP_012266991.1_5596 1 Reactome: R-HSA-2151201 "Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311297.1_prot_XP_012254110.1_1108 8 Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68616;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-68827;Reactome: R-HSA-113507 "Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation" lcl|NW_020311362.1_prot_XP_020710997.1_5874 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311361.1_prot_XP_012261473.1_5813 8 Reactome: R-HSA-68616;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68689;Reactome: R-HSA-176187 "Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress" lcl|NW_020311290.1_prot_XP_020707024.1_443 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311443.1_prot_XP_020710922.1_8913 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311397.1_prot_XP_020708720.1_7306 4 Reactome: R-HSA-9646399;Reactome: R-HSA-9615710;Reactome: R-HSA-3899300;Reactome: R-HSA-9613829 "Aggrephagy";"Late endosomal microautophagy";"SUMOylation of transcription cofactors";"Chaperone Mediated Autophagy" lcl|NW_020311306.1_prot_XP_012264195.1_2078 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311397.1_prot_XP_012253728.1_7338 3 KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109;MetaCyc: PWY-4261 "Glycerolipid metabolism";"Triglyceride biosynthesis";"Glycerol degradation I" lcl|NW_020311993.1_prot_XP_012262979.1_21359 12 Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-6804756;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-167200 "Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat" lcl|NW_020311933.1_prot_XP_020706968.1_10761 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" lcl|NW_020311962.1_prot_XP_020706712.1_13821 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311392.1_prot_XP_020706410.1_7083 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311966.1_prot_XP_012256732.1_14714 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" lcl|NW_020311292.1_prot_XP_020706873.1_563 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311289.1_prot_XP_012256046.1_410 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311984.1_prot_XP_012267666.1_20121 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" lcl|NW_020311956.1_prot_XP_020706562.1_12629 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311980.1_prot_XP_020709752.1_18776 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" lcl|NW_020311296.1_prot_XP_012262867.1_1051 1 Reactome: R-HSA-9033241 "Peroxisomal protein import" lcl|NW_020311965.1_prot_XP_012259609.1_14281 1 Reactome: R-HSA-5223345 "Miscellaneous transport and binding events" lcl|NW_020311964.1_prot_XP_025602515.1_13870 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311968.1_prot_XP_012253084.1_15433 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" lcl|NW_020311977.1_prot_XP_012263824.1_17620 4 Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)" lcl|NW_020311958.1_prot_XP_012255647.1_12939 1 Reactome: R-HSA-5368286 "Mitochondrial translation initiation" lcl|NW_020311497.1_prot_XP_012252144.1_9505 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" lcl|NW_020311960.1_prot_XP_020707439.1_13230 5 KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-6317 "Galactose metabolism";"D-galactose detoxification";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)" lcl|NW_020311313.1_prot_XP_012261900.1_3043 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" lcl|NW_020311395.1_prot_XP_012260730.1_7226 1 Reactome: R-HSA-5389840 "Mitochondrial translation elongation" lcl|NW_020311349.1_prot_XP_012251121.1_5266 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311994.1_prot_XP_012267419.1_21735 2 KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600 "Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" lcl|NW_020311978.1_prot_XP_012258063.1_18361 7 MetaCyc: PWY-8052;MetaCyc: PWY-6351;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11 "2-arachidonoylglycerol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism" lcl|NW_020311315.1_prot_XP_012265207.1_3134 1 Reactome: R-HSA-6807878 "COPI-mediated anterograde transport" lcl|NW_020311346.1_prot_XP_012262935.1_5010 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311333.1_prot_XP_012256064.1_4296 4 Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311966.1_prot_XP_012256357.1_15128 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311966.1_prot_XP_020708439.1_14448 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" lcl|NW_020311323.1_prot_XP_020712058.1_3507 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311977.1_prot_XP_012263709.1_17647 1 Reactome: R-HSA-427652 "Sodium-coupled phosphate cotransporters" lcl|NW_020311333.1_prot_XP_020708054.1_4260 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311972.1_prot_XP_020711994.1_16256 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" lcl|NW_020311943.1_prot_XP_012255317.1_11731 12 KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04926+2.7.11.1;Reactome: R-HSA-1839117;Reactome: R-HSA-193648;KEGG: 04714+2.7.11.1;Reactome: R-HSA-194840;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5655302;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"G alpha (12/13) signalling events";"Relaxin signaling pathway";"Signaling by cytosolic FGFR1 fusion mutants";"NRAGE signals death through JNK";"Thermogenesis";"Rho GTPase cycle";"Human immunodeficiency virus 1 infection";"Signaling by FGFR1 in disease";"mTOR signaling pathway" lcl|NW_020311988.1_prot_XP_012252743.1_20468 4 Reactome: R-HSA-389661;MetaCyc: PWY-7382;MetaCyc: PWY-6987;KEGG: 00785+2.3.1.181 "Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism" lcl|NW_020311971.1_prot_XP_012263547.1_16141 19 Reactome: R-HSA-5686938;Reactome: R-HSA-381426;Reactome: R-HSA-432142;Reactome: R-HSA-3000471;Reactome: R-HSA-8963901;Reactome: R-HSA-975634;Reactome: R-HSA-3000484;Reactome: R-HSA-3000497;Reactome: R-HSA-8963888;Reactome: R-HSA-8856828;Reactome: R-HSA-8964026;Reactome: R-HSA-202733;Reactome: R-HSA-8964038;Reactome: R-HSA-8964041;Reactome: R-HSA-3000480;Reactome: R-HSA-8964046;Reactome: R-HSA-8957275;Reactome: R-HSA-8866423;Reactome: R-HSA-8856825 "Regulation of TLR by endogenous ligand";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Platelet sensitization by LDL";"Scavenging by Class B Receptors";"Chylomicron remodeling";"Retinoid metabolism and transport";"Scavenging by Class F Receptors";"Scavenging by Class H Receptors";"Chylomicron assembly";"Clathrin-mediated endocytosis";"Chylomicron clearance";"Cell surface interactions at the vascular wall";"LDL clearance";"LDL remodeling";"Scavenging by Class A Receptors";"VLDL clearance";"Post-translational protein phosphorylation";"VLDL assembly";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311309.1_prot_XP_012259088.1_2264 26 Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-437239;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-380320;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-389960;Reactome: R-HSA-389977;Reactome: R-HSA-1445148;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-3371497;Reactome: R-HSA-5617833;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436 "Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"HCMV Early Events";"Recruitment of NuMA to mitotic centrosomes";"Separation of Sister Chromatids";"Aggrephagy";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Formation of tubulin folding intermediates by CCT/TriC";"Post-chaperonin tubulin folding pathway";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Cilium Assembly";"Kinesins";"Resolution of Sister Chromatid Cohesion";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311992.1_prot_XP_020711591.2_21207 4 KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3 "Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311907.1_prot_XP_012264866.1_10146 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311286.1_prot_XP_012256274.1_154 14 MetaCyc: PWY-7587;MetaCyc: PWY-5667;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-7417;MetaCyc: PWY-7589;MetaCyc: PWY-7411;MetaCyc: PWY-5981;MetaCyc: PWY-8055;MetaCyc: PWY-8053 "Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Glycerolipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Palmitoleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II" lcl|NW_020311974.1_prot_XP_012260113.1_16866 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311318.1_prot_XP_012253436.1_3309 2 Reactome: R-HSA-5620924;Reactome: R-HSA-5610787 "Intraflagellar transport";"Hedgehog 'off' state" lcl|NW_020311513.1_prot_XP_012266154.1_9832 3 Reactome: R-HSA-1236974;Reactome: R-HSA-1799339;Reactome: R-HSA-9609523 "ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" lcl|NW_020311978.1_prot_XP_020708675.1_18415 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311983.1_prot_XP_012255533.1_19648 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" lcl|NW_020311971.1_prot_XP_020709614.1_15835 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311945.1_prot_XP_012261697.1_11831 14 MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725 "Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)" lcl|NW_020311957.1_prot_XP_012263345.1_12887 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" lcl|NW_020311978.1_prot_XP_012258070.1_18250 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311973.1_prot_XP_020708864.1_16358 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311367.1_prot_XP_020709000.1_6098 10 MetaCyc: PWY-7559;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4061;MetaCyc: PWY-5826;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-7112;MetaCyc: PWY-4041;MetaCyc: PWY-6842;MetaCyc: PWY-8001 "Glutathione degradation (DUG pathway";"Cyanoamino acid metabolism";"Glutathione-mediated detoxification I";"Hypoglycin biosynthesis";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"4-hydroxy-2-nonenal detoxification";"Gamma-glutamyl cycle";"Glutathione-mediated detoxification II";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis" lcl|NW_020311984.1_prot_XP_012254484.1_19924 11 Reactome: R-HSA-909733;Reactome: R-HSA-389948;Reactome: R-HSA-912694;Reactome: R-HSA-114604;Reactome: R-HSA-512988;Reactome: R-HSA-877312;Reactome: R-HSA-9008059;Reactome: R-HSA-391160;Reactome: R-HSA-432142;Reactome: R-HSA-210990;Reactome: R-HSA-388841 "Interferon alpha/beta signaling";"PD-1 signaling";"Regulation of IFNA signaling";"GPVI-mediated activation cascade";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of IFNG signaling";"Interleukin-37 signaling";"Signal regulatory protein family interactions";"Platelet sensitization by LDL";"PECAM1 interactions";"Costimulation by the CD28 family" lcl|NW_020311313.1_prot_XP_020709966.1_2941 5 Reactome: R-HSA-196757;KEGG: 00670+1.5.1.3;MetaCyc: PWY-3841;KEGG: 00790+1.5.1.3;MetaCyc: PWY-6614 "Metabolism of folate and pterines";"One carbon pool by folate";"Folate transformations II (plants)";"Folate biosynthesis";"Tetrahydrofolate biosynthesis" lcl|NW_020311977.1_prot_XP_012263679.1_17791 17 MetaCyc: PWY-4381;MetaCyc: PWY-6679;Reactome: R-HSA-196780;KEGG: 00640+6.4.1.2;KEGG: 00254+6.4.1.2;Reactome: R-HSA-200425;Reactome: R-HSA-2426168;Reactome: R-HSA-163765;Reactome: R-HSA-3371599;KEGG: 00720+6.4.1.2;MetaCyc: PWY-5966-1;MetaCyc: PWY-5744;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6722;KEGG: 00620+6.4.1.2;MetaCyc: PWY-5743;MetaCyc: PWY-5789 "Fatty acid biosynthesis initiation (bacteria and plants)";"Jadomycin biosynthesis";"Biotin transport and metabolism";"Propanoate metabolism";"Aflatoxin biosynthesis";"Carnitine metabolism";"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression";"Defective HLCS causes multiple carboxylase deficiency";"Carbon fixation pathways in prokaryotes";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Glyoxylate assimilation";"Fatty acid biosynthesis";"Candicidin biosynthesis";"Pyruvate metabolism";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle" lcl|NW_020311988.1_prot_XP_025602939.1_20737 14 MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7602;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7725;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601 "Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Fatty acid elongation";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)" lcl|NW_020311935.1_prot_XP_012266608.1_10918 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311343.1_prot_XP_020708741.1_4779 3 MetaCyc: PWY-7511;Reactome: R-HSA-6798695;Reactome: R-HSA-983168 "Protein ubiquitination";"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311292.1_prot_XP_012252374.1_612 1 Reactome: R-HSA-390648 "Muscarinic acetylcholine receptors" lcl|NW_020311978.1_prot_XP_012257699.2_18302 4 Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187 "Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing" lcl|NW_020311961.1_prot_XP_012262579.2_13407 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" lcl|NW_020311957.1_prot_XP_020710485.1_12836 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" lcl|NW_020311947.1_prot_XP_012260636.1_11964 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" lcl|NW_020311382.1_prot_XP_012268017.1_6859 1 Reactome: R-HSA-69273 "Cyclin A/B1/B2 associated events during G2/M transition" lcl|NW_020311293.1_prot_XP_012251478.1_850 2 Reactome: R-HSA-2299718;Reactome: R-HSA-2514853 "Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes" lcl|NW_020311990.1_prot_XP_012266436.1_20853 2 KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1 "Purine metabolism";"Pentose phosphate pathway" lcl|NW_020311977.1_prot_XP_012253875.1_17585 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311315.1_prot_XP_012265240.1_3121 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311356.1_prot_XP_012267064.1_5565 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" lcl|NW_020311292.1_prot_XP_012262774.1_723 18 Reactome: R-HSA-1482839;Reactome: R-HSA-1482801;MetaCyc: PWY-8051;MetaCyc: PWY-7783;Reactome: R-HSA-1482925;MetaCyc: PWY-8053;MetaCyc: PWY-7409;Reactome: R-HSA-1482788;MetaCyc: PWY-7417;MetaCyc: PWY-6803;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482922;Reactome: R-HSA-1483166;KEGG: 00590+3.1.1.4;KEGG: 00592+3.1.1.4;KEGG: 00565+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7416 "Acyl chain remodelling of PE";"Acyl chain remodelling of PS";"Anandamide biosynthesis I";"Plasmalogen degradation";"Acyl chain remodelling of PG";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PC";"Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidylcholine acyl editing";"Linoleic acid metabolism";"Acyl chain remodelling of PI";"Synthesis of PA";"Arachidonic acid metabolism";"alpha-Linolenic acid metabolism";"Ether lipid metabolism";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)" lcl|NW_020311419.1_prot_XP_012254042.1_8093 13 MetaCyc: PWY-7220;MetaCyc: PWY-6545;Reactome: R-HSA-499943;MetaCyc: PWY-7184;KEGG: 00983+1.17.4.1;KEGG: 00230+1.17.4.1;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198;MetaCyc: PWY-7226;MetaCyc: PWY-7227;MetaCyc: PWY-7210;MetaCyc: PWY-7222;KEGG: 00480+1.17.4.1 "Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Purine metabolism";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism" lcl|NW_020311511.1_prot_XP_012250966.1_9656 6 MetaCyc: PWY-6983;MetaCyc: PWY-5663;MetaCyc: PWY-5664;MetaCyc: PWY-7442;Reactome: R-HSA-1474151;KEGG: 00790+4.2.3.12 "Threo-tetrahydrobiopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Erythro-tetrahydrobiopterin biosynthesis II";"Drosopterin and aurodrosopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis" lcl|NW_020311400.1_prot_XP_020710757.1_7395 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311432.1_prot_XP_020712259.1_8504 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" lcl|NW_020311966.1_prot_XP_012257321.1_14825 2 Reactome: R-HSA-376176;Reactome: R-HSA-5663220 "Signaling by ROBO receptors";"RHO GTPases Activate Formins" lcl|NW_020311967.1_prot_XP_020708009.1_15222 5 KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-112409;Reactome: R-HSA-5675221 "Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"RAF-independent MAPK1/3 activation";"Negative regulation of MAPK pathway" lcl|NW_020311985.1_prot_XP_020711087.1_20201 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311982.1_prot_XP_012258155.1_19343 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311961.1_prot_XP_012262550.1_13515 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311401.1_prot_XP_012254950.1_7597 3 Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482 "Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events" lcl|NW_020311978.1_prot_XP_020708577.1_18044 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311975.1_prot_XP_020711377.1_17194 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" lcl|NW_020311391.1_prot_XP_025601970.1_7055 3 Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482 "Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events" lcl|NW_020311974.1_prot_XP_020709386.1_16922 2 Reactome: R-HSA-202733;Reactome: R-HSA-416993 "Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors" lcl|NW_020311441.1_prot_XP_012251214.1_8873 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311301.1_prot_XP_012253053.1_1618 1 Reactome: R-HSA-211981 "Xenobiotics" lcl|NW_020311983.1_prot_XP_020707883.1_19795 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311503.1_prot_XP_012255250.1_9611 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311955.1_prot_XP_012265314.1_12498 42 Reactome: R-HSA-977225;Reactome: R-HSA-3214842;Reactome: R-HSA-5578749;Reactome: R-HSA-8936459;Reactome: R-HSA-5617472;Reactome: R-HSA-5625886;Reactome: R-HSA-5693565;Reactome: R-HSA-2559586;Reactome: R-HSA-2299718;Reactome: R-HSA-5693607;Reactome: R-HSA-5250924;Reactome: R-HSA-73772;Reactome: R-HSA-5334118;Reactome: R-HSA-110329;Reactome: R-HSA-1912408;Reactome: R-HSA-201722;Reactome: R-HSA-3214847;Reactome: R-HSA-606279;Reactome: R-HSA-9610379;Reactome: R-HSA-3214815;Reactome: R-HSA-2559580;Reactome: R-HSA-1221632;Reactome: R-HSA-4551638;Reactome: R-HSA-73728;Reactome: R-HSA-212300;Reactome: R-HSA-427389;Reactome: R-HSA-3214841;Reactome: R-HSA-9616222;Reactome: R-HSA-9609690;Reactome: R-HSA-912446;Reactome: R-HSA-5693571;Reactome: R-HSA-427413;Reactome: R-HSA-110328;Reactome: R-HSA-110331;Reactome: R-HSA-3214858;Reactome: R-HSA-110330;Reactome: R-HSA-2559582;Reactome: R-HSA-427359;Reactome: R-HSA-9018519;Reactome: R-HSA-8939236;Reactome: R-HSA-171306;Reactome: R-HSA-69473 "Amyloid fiber formation";"HDMs demethylate histones";"Transcriptional regulation by small RNAs";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"DNA Damage/Telomere Stress Induced Senescence";"Condensation of Prophase Chromosomes";"Processing of DNA double-strand break ends";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"DNA methylation";"Cleavage of the damaged pyrimidine";"Pre-NOTCH Transcription and Translation";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones";"Deposition of new CENPA-containing nucleosomes at the centromere";"HCMV Late Events";"HDACs deacetylate histones";"Oxidative Stress Induced Senescence";"Meiotic synapsis";"SUMOylation of chromatin organization proteins";"RNA Polymerase I Promoter Opening";"PRC2 methylates histones and DNA";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"PKMTs methylate histone lysines";"Transcriptional regulation of granulopoiesis";"HCMV Early Events";"Meiotic recombination";"Nonhomologous End-Joining (NHEJ)";"NoRC negatively regulates rRNA expression";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged purine";"RMTs methylate histone arginines";"Recognition and association of DNA glycosylase with site containing an affected purine";"Senescence-Associated Secretory Phenotype (SASP)";"SIRT1 negatively regulates rRNA expression";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Packaging Of Telomere Ends";"G2/M DNA damage checkpoint" lcl|NW_020311995.1_prot_XP_012256762.1_21978 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311291.1_prot_XP_012259655.1_464 2 Reactome: R-HSA-2032785;Reactome: R-HSA-8951671 "YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription" lcl|NW_020311992.1_prot_XP_012266282.1_21091 17 Reactome: R-HSA-69473;Reactome: R-HSA-75035;KEGG: 05165+2.7.11.1;Reactome: R-HSA-69601;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693616;KEGG: 04926+2.7.11.1;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6796648;Reactome: R-HSA-1433557;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6804756;Reactome: R-HSA-8953750;KEGG: 04714+2.7.11.1 "G2/M DNA damage checkpoint";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Human papillomavirus infection";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Presynaptic phase of homologous DNA pairing and strand exchange";"Relaxin signaling pathway";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"Human cytomegalovirus infection";"TP53 Regulates Transcription of DNA Repair Genes";"Signaling by SCF-KIT";"mTOR signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Transcriptional Regulation by E2F6";"Thermogenesis" lcl|NW_020311317.1_prot_XP_012251516.1_3199 31 MetaCyc: PWY-5973;Reactome: R-HSA-163765;Reactome: R-HSA-199220;Reactome: R-HSA-75105;MetaCyc: PWY-6519;MetaCyc: PWY-5147;Reactome: R-HSA-2426168;MetaCyc: PWY-5367;MetaCyc: PWY-4381;MetaCyc: PWY-5142;MetaCyc: PWYG-321;MetaCyc: PWY-6113;MetaCyc: PWY-7858;MetaCyc: PWY-7663;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5994;MetaCyc: PWY-6799;MetaCyc: PWY-8012;MetaCyc: PWY-5971;MetaCyc: PWY-7746;MetaCyc: PWY-5989;MetaCyc: PWY-8047;MetaCyc: PWY-5366;MetaCyc: PWY-7723;MetaCyc: PWY-8049;MetaCyc: PWY-5966-1;MetaCyc: PWY-6282;MetaCyc: PWY-7664;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-9029558;MetaCyc: PWY-7388 "Cis-vaccenate biosynthesis";"ChREBP activates metabolic gene expression";"Vitamin B5 (pantothenate) metabolism";"Fatty acyl-CoA biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Oleate biosynthesis I (plants)";"Activation of gene expression by SREBF (SREBP)";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Acyl-[acyl-carrier protein] thioesterase pathway";"";"Superpathway of mycolate biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Gondoate biosynthesis (anaerobic)";"Fatty acid biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Mupirocin biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Mycobacterial sulfolipid biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Bryostatin biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Bacterial bioluminescence";"Pederin biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Oleate biosynthesis IV (anaerobic)";"Biotin metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)" lcl|NW_020311373.1_prot_XP_020711632.1_6439 8 Reactome: R-HSA-5083633;MetaCyc: PWY-7921;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109 "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis" lcl|NW_020311966.1_prot_XP_020708100.1_15068 8 MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5173105;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;Reactome: R-HSA-5083629 "Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"O-linked glycosylation";"Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2" lcl|NW_020311970.1_prot_XP_012267506.1_15786 13 Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72689 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits" lcl|NW_020311994.1_prot_XP_025603022.1_21512 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311513.1_prot_XP_012265962.2_9849 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311979.1_prot_XP_020709208.1_18553 8 Reactome: R-HSA-428540;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1 "Activation of RAC1";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Thermogenesis" lcl|NW_020311978.1_prot_XP_020708572.1_18062 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311957.1_prot_XP_012262068.1_12749 4 Reactome: R-HSA-110312;Reactome: R-HSA-5655862;Reactome: R-HSA-5656121;Reactome: R-HSA-5656169 "Translesion synthesis by REV1";"Translesion synthesis by POLK";"Translesion synthesis by POLI";"Termination of translesion DNA synthesis" lcl|NW_020311296.1_prot_XP_012265113.1_1027 1 Reactome: R-HSA-428890 "Role of ABL in ROBO-SLIT signaling" lcl|NW_020311513.1_prot_XP_020711474.1_9732 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311472.1_prot_XP_012269235.1_9319 16 Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339 "Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311940.1_prot_XP_012265680.1_11279 3 MetaCyc: PWY-7800;MetaCyc: PWY-7799;Reactome: R-HSA-2514859 "Ac/N-end rule pathway";"Arg/N-end rule pathway (eukaryotic)";"Inactivation, recovery and regulation of the phototransduction cascade" lcl|NW_020311987.1_prot_XP_012256770.1_20377 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311966.1_prot_XP_012256954.1_14724 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311933.1_prot_XP_012258794.1_10738 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" lcl|NW_020311372.1_prot_XP_025601910.1_6325 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" lcl|NW_020311397.1_prot_XP_020708714.1_7289 3 Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311392.1_prot_XP_012250953.1_7082 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311977.1_prot_XP_012263850.1_17737 12 MetaCyc: PWY-5872;MetaCyc: PWY-5871;MetaCyc: PWY-5856;Reactome: R-HSA-2142789;MetaCyc: PWY-5870;MetaCyc: PWY-7233;KEGG: 00130+2.1.1.222+2.1.1.64;MetaCyc: PWY-6708;MetaCyc: PWY-5855;MetaCyc: PWY-5857;MetaCyc: PWY-5873;MetaCyc: PWY-7230 "Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)" lcl|NW_020311940.1_prot_XP_012265521.1_11241 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311327.1_prot_XP_025601726.1_3806 2 Reactome: R-HSA-171319;Reactome: R-HSA-6790901 "Telomere Extension By Telomerase";"rRNA modification in the nucleus and cytosol" lcl|NW_020311391.1_prot_XP_025601964.1_7051 3 Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482 "Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events" lcl|NW_020311298.1_prot_XP_012269922.1_1256 4 KEGG: 00785+2.8.1.8;MetaCyc: PWY-6987;Reactome: R-HSA-389661;MetaCyc: PWY-7382 "Lipoic acid metabolism";"Lipoate biosynthesis and incorporation III (Bacillus)";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation IV (yeast)" lcl|NW_020311977.1_prot_XP_012252236.1_17470 6 Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025 "RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311966.1_prot_XP_012256449.1_14618 1 Reactome: R-HSA-4615885 "SUMOylation of DNA replication proteins" lcl|NW_020311309.1_prot_XP_012259039.1_2287 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311309.1_prot_XP_012259067.1_2270 8 KEGG: 00030+5.3.1.6;Reactome: R-HSA-6791461;KEGG: 00051+5.3.1.6;MetaCyc: PWY-1861;MetaCyc: PWY-5723;Reactome: R-HSA-5659996;KEGG: 00710+5.3.1.6;Reactome: R-HSA-71336 "Pentose phosphate pathway";"RPIA deficiency: failed conversion of RU5P to R5P";"Fructose and mannose metabolism";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Rubisco shunt";"RPIA deficiency: failed conversion of R5P to RU5P";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway" lcl|NW_020311979.1_prot_XP_012259571.1_18625 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311995.1_prot_XP_012257083.1_21880 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311987.1_prot_XP_020709211.1_20456 5 Reactome: R-HSA-380994;Reactome: R-HSA-2426168;Reactome: R-HSA-9614657;Reactome: R-HSA-1989781;Reactome: R-HSA-381183 "ATF4 activates genes in response to endoplasmic reticulum stress";"Activation of gene expression by SREBF (SREBP)";"FOXO-mediated transcription of cell death genes";"PPARA activates gene expression";"ATF6 (ATF6-alpha) activates chaperone genes" lcl|NW_020311296.1_prot_XP_012264855.1_1003 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311432.1_prot_XP_012268798.1_8510 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" lcl|NW_020311420.1_prot_XP_020709538.1_8121 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311961.1_prot_XP_012262517.1_13317 2 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.7 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311988.1_prot_XP_020709738.1_20709 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" lcl|NW_020311292.1_prot_XP_012262808.1_712 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311966.1_prot_XP_012257248.1_14861 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311334.1_prot_XP_025601755.1_4346 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311943.1_prot_XP_012255255.1_11685 1 Reactome: R-HSA-6803204 "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" lcl|NW_020311992.1_prot_XP_020711533.1_21261 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311418.1_prot_XP_012261009.1_8007 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311992.1_prot_XP_020711524.1_21273 14 MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;MetaCyc: PWY-7416;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1482788;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7409 "Plasmalogen degradation";"Linoleic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Retinoid metabolism and transport";"Phospholipid remodeling (phosphatidylcholine, yeast)";"alpha-Linolenic acid metabolism";"Acyl chain remodelling of PC";"Arachidonic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)" lcl|NW_020311432.1_prot_XP_012268839.1_8357 13 Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-156827 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression" lcl|NW_020311915.1_prot_XP_012262416.1_10179 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311982.1_prot_XP_012258399.1_19274 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311324.1_prot_XP_012269321.1_3532 2 KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7 "Pyruvate metabolism";"Aminobenzoate degradation" lcl|NW_020311992.1_prot_XP_020711526.1_21016 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311983.1_prot_XP_020711792.1_19528 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311961.1_prot_XP_012262617.1_13530 5 Reactome: R-HSA-6804758;Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-427389 "Regulation of TP53 Activity through Acetylation";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" lcl|NW_020311296.1_prot_XP_012262834.1_1061 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311308.1_prot_XP_020710842.1_2186 8 Reactome: R-HSA-438066;Reactome: R-HSA-442982;Reactome: R-HSA-9620244;Reactome: R-HSA-9617324;KEGG: 00230+2.7.4.8;Reactome: R-HSA-5673001;Reactome: R-HSA-9609736;MetaCyc: PWY-7221 "Unblocking of NMDA receptors, glutamate binding and activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Long-term potentiation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Purine metabolism";"RAF/MAP kinase cascade";"Assembly and cell surface presentation of NMDA receptors";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311355.1_prot_XP_020706982.1_5502 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311961.1_prot_XP_020710193.1_13422 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311940.1_prot_XP_012265572.1_11203 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311978.1_prot_XP_012257886.1_18439 6 KEGG: 00030+3.1.1.17;MetaCyc: PWY-5530;KEGG: 00053+3.1.1.17;MetaCyc: PWY-2221;KEGG: 00930+3.1.1.17;MetaCyc: PWY-7165 "Pentose phosphate pathway";"Sorbitol biosynthesis II";"Ascorbate and aldarate metabolism";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Caprolactam degradation";"L-ascorbate biosynthesis VI (engineered pathway)" lcl|NW_020311361.1_prot_XP_012261549.1_5804 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311360.1_prot_XP_020706615.1_5733 6 Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68867 "Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Unwinding of DNA";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex" lcl|NW_020311507.1_prot_XP_012259687.1_9625 11 Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-163359;Reactome: R-HSA-163615;Reactome: R-HSA-418597;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660 "PKA activation in glucagon signalling";"G alpha (s) signalling events";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon signaling in metabolic regulation";"PKA activation";"G alpha (z) signalling events";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase activating pathway" lcl|NW_020311925.1_prot_XP_012258433.1_10515 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311313.1_prot_XP_012261860.1_2899 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311957.1_prot_XP_012263335.1_12842 5 Reactome: R-HSA-4420097;Reactome: R-HSA-171007;Reactome: R-HSA-376172;Reactome: R-HSA-168638;KEGG: 04150+2.7.11.24 "VEGFA-VEGFR2 Pathway";"p38MAPK events";"DSCAM interactions";"NOD1/2 Signaling Pathway";"mTOR signaling pathway" lcl|NW_020311946.1_prot_XP_012268602.1_11895 2 Reactome: R-HSA-6782315;Reactome: R-HSA-6787450 "tRNA modification in the nucleus and cytosol";"tRNA modification in the mitochondrion" lcl|NW_020311975.1_prot_XP_020707593.1_17029 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311373.1_prot_XP_012266678.1_6434 13 Reactome: R-HSA-3928662;Reactome: R-HSA-4420097;Reactome: R-HSA-416572;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5627117;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3928663;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04926+2.7.11.1 "EPHB-mediated forward signaling";"VEGFA-VEGFR2 Pathway";"Sema4D induced cell migration and growth-cone collapse";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"RHO GTPases Activate ROCKs";"mTOR signaling pathway";"EPHA-mediated growth cone collapse";"Human immunodeficiency virus 1 infection";"Thermogenesis";"G alpha (12/13) signalling events";"Relaxin signaling pathway" lcl|NW_020311965.1_prot_XP_012260315.1_14058 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311311.1_prot_XP_012250862.1_2550 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311987.1_prot_XP_020709188.1_20455 5 Reactome: R-HSA-1989781;Reactome: R-HSA-381183;Reactome: R-HSA-9614657;Reactome: R-HSA-2426168;Reactome: R-HSA-380994 "PPARA activates gene expression";"ATF6 (ATF6-alpha) activates chaperone genes";"FOXO-mediated transcription of cell death genes";"Activation of gene expression by SREBF (SREBP)";"ATF4 activates genes in response to endoplasmic reticulum stress" lcl|NW_020311992.1_prot_XP_012266419.1_21188 5 Reactome: R-HSA-2122947;Reactome: R-HSA-3214815;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862 "NOTCH1 Intracellular Domain Regulates Transcription";"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants" lcl|NW_020311334.1_prot_XP_020711339.1_4354 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311964.1_prot_XP_025602534.1_13913 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311305.1_prot_XP_012264026.1_1982 3 KEGG: 00860+2.5.1.17;Reactome: R-HSA-196741;Reactome: R-HSA-3359471 "Porphyrin and chlorophyll metabolism";"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective MMAB causes methylmalonic aciduria type cblB" lcl|NW_020311958.1_prot_XP_012260390.1_12902 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311959.1_prot_XP_012262299.1_13098 5 MetaCyc: PWY-5083;MetaCyc: PWY-7268;Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269 "NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)" lcl|NW_020311992.1_prot_XP_012266432.1_21227 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311291.1_prot_XP_012259384.1_485 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311926.1_prot_XP_012250863.1_10616 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" lcl|NW_020311955.1_prot_XP_020711187.1_12399 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311418.1_prot_XP_012261030.1_8041 3 Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807 "Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism" lcl|NW_020311907.1_prot_XP_012264881.1_10140 4 KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361;MetaCyc: PWY-7174;Reactome: R-HSA-1237112 "Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Methionine salvage pathway" lcl|NW_020311382.1_prot_XP_012268028.1_6851 4 Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825 "Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311977.1_prot_XP_012263756.1_17648 1 Reactome: R-HSA-6811438 "Intra-Golgi traffic" lcl|NW_020311934.1_prot_XP_020707781.1_10806 2 KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386 "Pyruvate metabolism";"Methylglyoxal degradation I" lcl|NW_020311988.1_prot_XP_020712292.1_20581 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311416.1_prot_XP_012253687.1_7937 5 Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-3214815;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription" lcl|NW_020311300.1_prot_XP_012253265.1_1513 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311970.1_prot_XP_012267572.1_15789 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.4 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311300.1_prot_XP_012253250.1_1570 1 Reactome: R-HSA-8876725 "Protein methylation" lcl|NW_020311984.1_prot_XP_020711921.1_20141 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311365.1_prot_XP_012259874.1_5948 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311482.1_prot_XP_020712162.1_9474 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311978.1_prot_XP_020708657.1_18102 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311955.1_prot_XP_020711219.1_12417 1 KEGG: 04150+2.7.11.24 "mTOR signaling pathway" lcl|NW_020311955.1_prot_XP_020711147.1_12385 10 MetaCyc: PWY-7328;MetaCyc: PWY-6397;MetaCyc: PWY-3821;Reactome: R-HSA-70370;MetaCyc: PWY-6317;Reactome: R-HSA-5609977;MetaCyc: PWY-6527;KEGG: 00520+5.1.3.2;MetaCyc: PWY-7344;KEGG: 00052+5.1.3.2 "Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose detoxification";"Galactose catabolism";"D-galactose degradation I (Leloir pathway)";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"UDP-alpha-D-galactose biosynthesis";"Galactose metabolism" lcl|NW_020311305.1_prot_XP_012263808.1_1999 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311957.1_prot_XP_012262144.1_12748 2 Reactome: R-HSA-191859;Reactome: R-HSA-6807505 "snRNP Assembly";"RNA polymerase II transcribes snRNA genes" lcl|NW_020311994.1_prot_XP_020710047.1_21844 4 Reactome: R-HSA-2022090;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216;Reactome: R-HSA-1650814 "Assembly of collagen fibrils and other multimeric structures";"Collagen degradation";"Collagen chain trimerization";"Collagen biosynthesis and modifying enzymes" lcl|NW_020311308.1_prot_XP_020710832.1_2185 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311988.1_prot_XP_012269222.1_20633 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311995.1_prot_XP_012256972.1_21948 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311418.1_prot_XP_012260995.1_7979 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311298.1_prot_XP_012250539.1_1202 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311977.1_prot_XP_012264041.1_17883 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311978.1_prot_XP_012257898.1_18344 3 MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174 "S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II" lcl|NW_020311365.1_prot_XP_012269440.1_6029 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" lcl|NW_020311973.1_prot_XP_012258646.1_16566 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" lcl|NW_020311957.1_prot_XP_012262075.1_12754 7 Reactome: R-HSA-9023661;Reactome: R-HSA-9020265;Reactome: R-HSA-9018676;Reactome: R-HSA-9018681;Reactome: R-HSA-2142691;Reactome: R-HSA-9018896;Reactome: R-HSA-6798695 "Biosynthesis of E-series 18(R)-resolvins";"Biosynthesis of aspirin-triggered D-series resolvins";"Biosynthesis of D-series resolvins";"Biosynthesis of protectins";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Biosynthesis of E-series 18(S)-resolvins";"Neutrophil degranulation" lcl|NW_020311941.1_prot_XP_020707086.1_11428 13 Reactome: R-HSA-445989;Reactome: R-HSA-2871837;Reactome: R-HSA-5607764;Reactome: R-HSA-450302;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-975163;Reactome: R-HSA-168638;Reactome: R-HSA-9645460;Reactome: R-HSA-9014325;Reactome: R-HSA-450321;Reactome: R-HSA-9020702;Reactome: R-HSA-937042 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"FCERI mediated NF-kB activation";"CLEC7A (Dectin-1) signaling";"activated TAK1 mediates p38 MAPK activation";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"NOD1/2 Signaling Pathway";"Alpha-protein kinase 1 signaling pathway";"TICAM1,TRAF6-dependent induction of TAK1 complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Interleukin-1 signaling";"IRAK2 mediated activation of TAK1 complex" lcl|NW_020311917.1_prot_XP_012251031.1_10239 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311289.1_prot_XP_012256149.1_400 2 Reactome: R-HSA-1268020;Reactome: R-HSA-1362409 "Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis" lcl|NW_020311995.1_prot_XP_012256358.1_21986 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311393.1_prot_XP_020711294.1_7214 5 Reactome: R-HSA-1445148;Reactome: R-HSA-5625740;Reactome: R-HSA-111447;Reactome: R-HSA-5628897;Reactome: R-HSA-75035 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate PKNs";"Activation of BAD and translocation to mitochondria";"TP53 Regulates Metabolic Genes";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" lcl|NW_020311984.1_prot_XP_012254483.1_19925 11 Reactome: R-HSA-9008059;Reactome: R-HSA-391160;Reactome: R-HSA-432142;Reactome: R-HSA-210990;Reactome: R-HSA-388841;Reactome: R-HSA-909733;Reactome: R-HSA-389948;Reactome: R-HSA-912694;Reactome: R-HSA-114604;Reactome: R-HSA-512988;Reactome: R-HSA-877312 "Interleukin-37 signaling";"Signal regulatory protein family interactions";"Platelet sensitization by LDL";"PECAM1 interactions";"Costimulation by the CD28 family";"Interferon alpha/beta signaling";"PD-1 signaling";"Regulation of IFNA signaling";"GPVI-mediated activation cascade";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of IFNG signaling" lcl|NW_020311966.1_prot_XP_012256376.1_14956 7 Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "RHO GTPases Activate Formins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311287.1_prot_XP_012268114.1_262 4 KEGG: 00600+3.5.1.23;MetaCyc: PWY-6483;Reactome: R-HSA-1660662;MetaCyc: PWY-7119 "Sphingolipid metabolism";"Ceramide degradation (generic)";"Glycosphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)" lcl|NW_020311976.1_prot_XP_012253607.1_17288 1 Reactome: R-HSA-1483191 "Synthesis of PC" lcl|NW_020311432.1_prot_XP_012268705.1_8460 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311359.1_prot_XP_012252102.1_5708 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" lcl|NW_020311419.1_prot_XP_012254058.1_8074 1 Reactome: R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" lcl|NW_020311994.1_prot_XP_012267548.1_21688 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" lcl|NW_020311418.1_prot_XP_020709689.1_8039 3 Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621 "Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism" lcl|NW_020311932.1_prot_XP_012257421.1_10717 6 KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1855204;KEGG: 00562+3.1.3.36;Reactome: R-HSA-194840 "Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Rho GTPase cycle" lcl|NW_020311967.1_prot_XP_020708008.1_15221 5 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-112409;Reactome: R-HSA-5675221 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"RAF-independent MAPK1/3 activation";"Negative regulation of MAPK pathway" lcl|NW_020311286.1_prot_XP_012257180.1_140 6 MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508 "Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis" lcl|NW_020311995.1_prot_XP_012257154.1_21945 3 KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16 "Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer" lcl|NW_020311985.1_prot_XP_012265192.1_20244 42 Reactome: R-HSA-427413;Reactome: R-HSA-5693571;Reactome: R-HSA-912446;Reactome: R-HSA-9609690;Reactome: R-HSA-9616222;Reactome: R-HSA-3214841;Reactome: R-HSA-427389;Reactome: R-HSA-73728;Reactome: R-HSA-212300;Reactome: R-HSA-1221632;Reactome: R-HSA-4551638;Reactome: R-HSA-69473;Reactome: R-HSA-171306;Reactome: R-HSA-8939236;Reactome: R-HSA-9018519;Reactome: R-HSA-427359;Reactome: R-HSA-2559582;Reactome: R-HSA-110330;Reactome: R-HSA-3214858;Reactome: R-HSA-110331;Reactome: R-HSA-110328;Reactome: R-HSA-5250924;Reactome: R-HSA-5693607;Reactome: R-HSA-2299718;Reactome: R-HSA-2559586;Reactome: R-HSA-5693565;Reactome: R-HSA-5625886;Reactome: R-HSA-5617472;Reactome: R-HSA-8936459;Reactome: R-HSA-5578749;Reactome: R-HSA-3214842;Reactome: R-HSA-977225;Reactome: R-HSA-2559580;Reactome: R-HSA-3214815;Reactome: R-HSA-9610379;Reactome: R-HSA-606279;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-1912408;Reactome: R-HSA-110329;Reactome: R-HSA-73772;Reactome: R-HSA-5334118 "NoRC negatively regulates rRNA expression";"Nonhomologous End-Joining (NHEJ)";"Meiotic recombination";"HCMV Early Events";"Transcriptional regulation of granulopoiesis";"PKMTs methylate histone lysines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Opening";"PRC2 methylates histones and DNA";"Meiotic synapsis";"SUMOylation of chromatin organization proteins";"G2/M DNA damage checkpoint";"Packaging Of Telomere Ends";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Estrogen-dependent gene expression";"SIRT1 negatively regulates rRNA expression";"Senescence-Associated Secretory Phenotype (SASP)";"Recognition and association of DNA glycosylase with site containing an affected purine";"RMTs methylate histone arginines";"Cleavage of the damaged purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"B-WICH complex positively regulates rRNA expression";"Processing of DNA double-strand break ends";"Condensation of Prophase Chromosomes";"DNA Damage/Telomere Stress Induced Senescence";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional regulation by small RNAs";"HDMs demethylate histones";"Amyloid fiber formation";"Oxidative Stress Induced Senescence";"HDACs deacetylate histones";"HCMV Late Events";"Deposition of new CENPA-containing nucleosomes at the centromere";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Pre-NOTCH Transcription and Translation";"Cleavage of the damaged pyrimidine";"RNA Polymerase I Promoter Escape";"DNA methylation" lcl|NW_020311988.1_prot_XP_020709736.1_20705 3 Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081 "Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling" lcl|NW_020311929.1_prot_XP_020712024.1_10671 9 Reactome: R-HSA-1632852;Reactome: R-HSA-9639288;Reactome: R-HSA-5674135;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-6798695 "Macroautophagy";"Amino acids regulate mTORC1";"MAP2K and MAPK activation";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Neutrophil degranulation" lcl|NW_020311313.1_prot_XP_012261861.1_2900 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311984.1_prot_XP_012254494.1_19922 12 KEGG: 00561+2.7.7.9;MetaCyc: PWY-7238;MetaCyc: PWY-7817;KEGG: 00520+2.7.7.9;Reactome: R-HSA-3322077;Reactome: R-HSA-173599;MetaCyc: PWY-6527;MetaCyc: PWY-7343;KEGG: 00040+2.7.7.9;KEGG: 00500+2.7.7.9;KEGG: 00052+2.7.7.9;MetaCyc: PWY-3801 "Glycerolipid metabolism";"Sucrose biosynthesis II";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Amino sugar and nucleotide sugar metabolism";"Glycogen synthesis";"Formation of the active cofactor, UDP-glucuronate";"Stachyose degradation";"UDP-alpha-D-glucose biosynthesis I";"Pentose and glucuronate interconversions";"Starch and sucrose metabolism";"Galactose metabolism";"Sucrose degradation II (sucrose synthase)" lcl|NW_020311958.1_prot_XP_012255536.1_12926 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311970.1_prot_XP_012256817.1_15730 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311992.1_prot_XP_020709598.1_20962 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311419.1_prot_XP_012254051.1_8083 5 MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109 "Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis" lcl|NW_020311961.1_prot_XP_020710192.1_13421 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311915.1_prot_XP_020710161.1_10180 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311287.1_prot_XP_020711795.1_259 4 MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23;MetaCyc: PWY-6483;Reactome: R-HSA-1660662 "Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism";"Ceramide degradation (generic)";"Glycosphingolipid metabolism" lcl|NW_020311976.1_prot_XP_012257856.1_17356 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" lcl|NW_020311360.1_prot_XP_012251616.1_5764 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" lcl|NW_020311298.1_prot_XP_012269900.1_1234 5 KEGG: 00561+3.2.1.22;KEGG: 00052+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;MetaCyc: PWY-6527 "Glycerolipid metabolism";"Galactose metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Stachyose degradation" lcl|NW_020311388.1_prot_XP_012262174.1_6949 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" lcl|NW_020311448.1_prot_XP_012252661.1_9032 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311974.1_prot_XP_012259847.1_16700 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311941.1_prot_XP_012253274.1_11389 7 MetaCyc: PWY-6596;KEGG: 00230+1.1.1.205;MetaCyc: PWY-5695;Reactome: R-HSA-73817;MetaCyc: PWY-7221;Reactome: R-HSA-6798695;KEGG: 00983+1.1.1.205 "Adenosine nucleotides degradation I";"Purine metabolism";"Inosine 5'-phosphate degradation";"Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Neutrophil degranulation";"Drug metabolism - other enzymes" lcl|NW_020311354.1_prot_XP_020709561.1_5492 13 MetaCyc: PWY-8052;Reactome: R-HSA-2871809;Reactome: R-HSA-202433;MetaCyc: PWY-6351;MetaCyc: PWY-6367;Reactome: R-HSA-2029485;Reactome: R-HSA-9027277;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11;Reactome: R-HSA-2871796;KEGG: 00562+3.1.4.11;Reactome: R-HSA-2424491;MetaCyc: PWY-7039 "2-arachidonoylglycerol biosynthesis";"FCERI mediated Ca+2 mobilization";"Generation of second messenger molecules";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"D-myo-inositol-5-phosphate metabolism";"Role of phospholipids in phagocytosis";"Erythropoietin activates Phospholipase C gamma (PLCG)";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"FCERI mediated MAPK activation";"Inositol phosphate metabolism";"DAP12 signaling";"Phosphatidate metabolism, as a signaling molecule" lcl|NW_020311940.1_prot_XP_012265674.1_11246 14 MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-5972;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-7036 "Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II" lcl|NW_020311994.1_prot_XP_020710044.1_21845 4 Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814 "Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"Collagen degradation";"Collagen biosynthesis and modifying enzymes" lcl|NW_020311973.1_prot_XP_012258644.1_16564 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" lcl|NW_020311970.1_prot_XP_012269074.1_15609 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311972.1_prot_XP_012267845.1_16248 2 Reactome: R-HSA-8876198;Reactome: R-HSA-8873719 "RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation" lcl|NW_020311513.1_prot_XP_012266188.1_9892 6 KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952;MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578 "Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway" lcl|NW_020311325.1_prot_XP_020706329.1_3684 3 KEGG: 00790+6.3.2.17;Reactome: R-HSA-196757;MetaCyc: PWY-2161 "Folate biosynthesis";"Metabolism of folate and pterines";"Folate polyglutamylation" lcl|NW_020311995.1_prot_XP_012257040.1_21884 7 KEGG: 00562+3.1.3.25;MetaCyc: PWY-2301;Reactome: R-HSA-1855183;MetaCyc: PWY-6363;MetaCyc: PWY-4702;KEGG: 00521+3.1.3.25;KEGG: 04070+3.1.3.25 "Inositol phosphate metabolism";"Myo-inositol biosynthesis";"Synthesis of IP2, IP, and Ins in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Phytate degradation I";"Streptomycin biosynthesis";"Phosphatidylinositol signaling system" lcl|NW_020311292.1_prot_XP_012252462.1_528 7 KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311973.1_prot_XP_020708929.1_16632 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311315.1_prot_XP_012265169.1_3110 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311981.1_prot_XP_012257453.1_19069 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311373.1_prot_XP_012263112.1_6393 3 Reactome: R-HSA-425561;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Sodium/Calcium exchangers";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311373.1_prot_XP_012266723.1_6475 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311388.1_prot_XP_012264837.1_6968 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311370.1_prot_XP_020710065.1_6263 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311432.1_prot_XP_012268809.1_8423 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" lcl|NW_020311966.1_prot_XP_012256608.1_15112 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" lcl|NW_020311417.1_prot_XP_025602030.1_7961 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" lcl|NW_020311966.1_prot_XP_012256382.1_14959 7 Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-141444;Reactome: R-HSA-68877 "EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase" lcl|NW_020311359.1_prot_XP_012252106.1_5701 1 Reactome: R-HSA-419037 "NCAM1 interactions" lcl|NW_020311977.1_prot_XP_012253847.1_17571 14 KEGG: 00230+1.17.1.4;MetaCyc: PWY-6596;MetaCyc: PWY-6607;KEGG: 00983+1.17.3.2;MetaCyc: PWY-5695;MetaCyc: PWY-6999;MetaCyc: PWY-6606;MetaCyc: PWY-6608;Reactome: R-HSA-74259;KEGG: 00232+1.17.3.2;MetaCyc: PWY-6538;Reactome: R-HSA-8851680;KEGG: 00230+1.17.1.4+1.17.3.2;MetaCyc: PWY-5497 "Purine metabolism";"Adenosine nucleotides degradation I";"Guanosine nucleotides degradation I";"Drug metabolism - other enzymes";"Inosine 5'-phosphate degradation";"Theophylline degradation";"Guanosine nucleotides degradation II";"Guanosine nucleotides degradation III";"Purine catabolism";"Caffeine metabolism";"Caffeine degradation III (bacteria, via demethylation)";"Butyrophilin (BTN) family interactions";"Purine metabolism";"Purine nucleobases degradation II (anaerobic)" lcl|NW_020311334.1_prot_XP_020711363.1_4380 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311448.1_prot_XP_012252689.1_9004 1 Reactome: R-HSA-977347 "Serine biosynthesis" lcl|NW_020311304.1_prot_XP_012259997.1_1848 1 Reactome: R-HSA-3108214 "SUMOylation of DNA damage response and repair proteins" lcl|NW_020311978.1_prot_XP_012257771.1_18389 2 Reactome: R-HSA-71403;Reactome: R-HSA-1268020 "Citric acid cycle (TCA cycle)";"Mitochondrial protein import" lcl|NW_020311973.1_prot_XP_012258572.1_16342 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311943.1_prot_XP_020707819.1_11700 6 Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA" lcl|NW_020311976.1_prot_XP_020708596.1_17417 1 Reactome: R-HSA-5693565 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" lcl|NW_020311302.1_prot_XP_020710869.1_1675 3 Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961 "Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II" lcl|NW_020311984.1_prot_XP_020711920.1_20073 6 MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84 "Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis" lcl|NW_020311978.1_prot_XP_012257772.1_18388 5 MetaCyc: PWY-3841;KEGG: 00720+1.5.1.20;KEGG: 00670+1.5.1.20;MetaCyc: PWY-2201;Reactome: R-HSA-196757 "Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"One carbon pool by folate";"Folate transformations I";"Metabolism of folate and pterines" lcl|NW_020311981.1_prot_XP_012257524.1_19016 4 Reactome: R-HSA-2173789;Reactome: R-HSA-3304356;Reactome: R-HSA-3656532;Reactome: R-HSA-2173788 "TGF-beta receptor signaling activates SMADs";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"Downregulation of TGF-beta receptor signaling" lcl|NW_020311979.1_prot_XP_012259491.1_18560 1 Reactome: R-HSA-5676934 "Protein repair" lcl|NW_020311383.1_prot_XP_012251549.1_6883 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311313.1_prot_XP_012261927.1_2950 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311528.1_prot_XP_012258495.1_9966 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311301.1_prot_XP_020707030.1_1621 1 Reactome: R-HSA-211981 "Xenobiotics" lcl|NW_020311413.1_prot_XP_012254392.1_7894 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311393.1_prot_XP_020711293.1_7211 5 Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-5625740 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs" lcl|NW_020311286.1_prot_XP_012256562.1_159 7 MetaCyc: PWY-46;KEGG: 00220+3.5.3.1;KEGG: 00330+3.5.3.1;MetaCyc: PWY-4984;MetaCyc: PWY-31;Reactome: R-HSA-70635;MetaCyc: PWY-6922 "Putrescine biosynthesis III";"Arginine biosynthesis";"Arginine and proline metabolism";"Urea cycle";"Canavanine degradation";"Urea cycle";"L-Ndelta-acetylornithine biosynthesis" lcl|NW_020311333.1_prot_XP_012255893.1_4221 20 Reactome: R-HSA-5696400;Reactome: R-HSA-110312;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5696397;Reactome: R-HSA-110320;Reactome: R-HSA-5656121;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-174411;Reactome: R-HSA-69473;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-5655862;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-5693616;Reactome: R-HSA-176187;Reactome: R-HSA-110314;Reactome: R-HSA-69091 "Dual Incision in GG-NER";"Translesion synthesis by REV1";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion Synthesis by POLH";"Translesion synthesis by POLI";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Polymerase switching on the C-strand of the telomere";"G2/M DNA damage checkpoint";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"Recognition of DNA damage by PCNA-containing replication complex";"Polymerase switching" lcl|NW_020311329.1_prot_XP_012258933.1_3936 13 Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9010553 "Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311373.1_prot_XP_012251298.1_6500 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" lcl|NW_020311971.1_prot_XP_012260784.1_15945 1 Reactome: R-HSA-72165 "mRNA Splicing - Minor Pathway" lcl|NW_020311993.1_prot_XP_012261856.1_21404 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" lcl|NW_020311436.1_prot_XP_012258220.1_8780 3 MetaCyc: PWY-6596;Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6 "Adenosine nucleotides degradation I";"Purine salvage";"Purine metabolism" lcl|NW_020311294.1_prot_XP_012264895.1_894 15 Reactome: R-HSA-5693616;Reactome: R-HSA-5693548;Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5685939;Reactome: R-HSA-2559586;Reactome: R-HSA-5685938;Reactome: R-HSA-5693571;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-912446;Reactome: R-HSA-5693568 "Presynaptic phase of homologous DNA pairing and strand exchange";"Sensing of DNA Double Strand Breaks";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"HDR through MMEJ (alt-NHEJ)";"DNA Damage/Telomere Stress Induced Senescence";"HDR through Single Strand Annealing (SSA)";"Nonhomologous End-Joining (NHEJ)";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Meiotic recombination";"Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311365.1_prot_XP_012259878.1_5951 3 Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-191859 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"snRNP Assembly" lcl|NW_020311968.1_prot_XP_020711939.1_15390 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311971.1_prot_XP_012260805.1_15852 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311313.1_prot_XP_012261868.1_2936 2 Reactome: R-HSA-204174;Reactome: R-HSA-5362517 "Regulation of pyruvate dehydrogenase (PDH) complex";"Signaling by Retinoic Acid" lcl|NW_020311995.1_prot_XP_020708158.1_22034 9 Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-167162;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-76042;Reactome: R-HSA-73779 "HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311373.1_prot_XP_012266696.1_6463 16 Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557 "Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis" lcl|NW_020311959.1_prot_XP_020710140.1_13097 5 MetaCyc: PWY-7268;MetaCyc: PWY-5083;Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269 "NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)" lcl|NW_020311988.1_prot_XP_012268442.1_20640 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311940.1_prot_XP_012265682.1_11236 3 KEGG: 00970+6.1.1.14;Reactome: R-HSA-379716;Reactome: R-HSA-379726 "Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Mitochondrial tRNA aminoacylation" lcl|NW_020311985.1_prot_XP_012265188.1_20243 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311957.1_prot_XP_012261025.1_12679 2 Reactome: R-HSA-430039;Reactome: R-HSA-72163 "mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway" lcl|NW_020311343.1_prot_XP_012258479.1_4854 182 Reactome: R-HSA-937042;Reactome: R-HSA-6807004;Reactome: R-HSA-174490;Reactome: R-HSA-4641263;Reactome: R-HSA-2672351;Reactome: R-HSA-211733;Reactome: R-HSA-532668;Reactome: R-HSA-72706;Reactome: R-HSA-8876493;Reactome: R-HSA-9033241;Reactome: R-HSA-5632684;Reactome: R-HSA-6804757;Reactome: R-HSA-174113;Reactome: R-HSA-168638;Reactome: R-HSA-180534;Reactome: R-HSA-174048;Reactome: R-HSA-6781823;Reactome: R-HSA-1169408;Reactome: R-HSA-2173795;Reactome: R-HSA-5205685;Reactome: R-HSA-9604323;Reactome: R-HSA-179409;Reactome: R-HSA-5658442;Reactome: R-HSA-5656169;Reactome: R-HSA-205043;Reactome: R-HSA-450302;Reactome: R-HSA-6781827;Reactome: R-HSA-9020702;Reactome: R-HSA-937041;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-5696397;Reactome: R-HSA-5654732;Reactome: R-HSA-6804756;Reactome: R-HSA-1799339;Reactome: R-HSA-5696394;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-72695;Reactome: R-HSA-3785653;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-3769402;Reactome: R-HSA-8856825;Reactome: R-HSA-168927;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-175474;Reactome: R-HSA-8939902;Reactome: R-HSA-975163;Reactome: R-HSA-201681;Reactome: R-HSA-72689;Reactome: R-HSA-68949;Reactome: R-HSA-9636383;Reactome: R-HSA-3322077;Reactome: R-HSA-937039;Reactome: R-HSA-1358803;Reactome: R-HSA-9013507;Reactome: R-HSA-110320;Reactome: R-HSA-400253;Reactome: R-HSA-5689603;Reactome: R-HSA-5357905;Reactome: R-HSA-202424;Reactome: R-HSA-9646399;Reactome: R-HSA-156827;Reactome: R-HSA-182971;Reactome: R-HSA-8951664;Reactome: R-HSA-9633012;Reactome: R-HSA-912631;Reactome: R-HSA-8866652;Reactome: R-HSA-5655862;Reactome: R-HSA-69481;Reactome: R-HSA-975110;Reactome: R-HSA-6804760;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5689896;Reactome: R-HSA-917729;Reactome: R-HSA-5684264;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-9637628;Reactome: R-HSA-5654733;Reactome: R-HSA-5693607;Reactome: R-HSA-168928;Reactome: R-HSA-4608870;Reactome: R-HSA-937072;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-9615710;Reactome: R-HSA-349425;Reactome: R-HSA-6782210;Reactome: R-HSA-8854050;Reactome: R-HSA-5654726;Reactome: R-HSA-69231;Reactome: R-HSA-936440;Reactome: R-HSA-382556;Reactome: R-HSA-5675221;Reactome: R-HSA-174154;Reactome: R-HSA-5656121;Reactome: R-HSA-2559582;Reactome: R-HSA-8863795;Reactome: R-HSA-5689901;Reactome: R-HSA-2565942;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-936964;Reactome: R-HSA-8948747;Reactome: R-HSA-975957;Reactome: R-HSA-209543;Reactome: R-HSA-5689880;Reactome: R-HSA-2559585;Reactome: R-HSA-2173788;Reactome: R-HSA-901032;Reactome: R-HSA-6783310;Reactome: R-HSA-8875360;Reactome: R-HSA-209560;Reactome: R-HSA-110312;Reactome: R-HSA-2979096;Reactome: R-HSA-5357956;Reactome: R-HSA-187577;Reactome: R-HSA-5685942;Reactome: R-HSA-4641258;Reactome: R-HSA-156902;Reactome: R-HSA-174178;Reactome: R-HSA-977225;Reactome: R-HSA-9014325;Reactome: R-HSA-2122948;Reactome: R-HSA-5610785;Reactome: R-HSA-2408557;Reactome: R-HSA-3134975;Reactome: R-HSA-174184;Reactome: R-HSA-1253288;Reactome: R-HSA-5675482;Reactome: R-HSA-5696400;Reactome: R-HSA-1169091;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-2173791;Reactome: R-HSA-2173796;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236;Reactome: R-HSA-445989;Reactome: R-HSA-8849469;Reactome: R-HSA-5689877;Reactome: R-HSA-1295596;Reactome: R-HSA-2691232;Reactome: R-HSA-450408;Reactome: R-HSA-1236382;Reactome: R-HSA-192823;Reactome: R-HSA-975144;Reactome: R-HSA-8948751;Reactome: R-HSA-2644606;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-110314;Reactome: R-HSA-4641257;Reactome: R-HSA-9613829;Reactome: R-HSA-917937;Reactome: R-HSA-72702;Reactome: R-HSA-2559580;Reactome: R-HSA-8866654;Reactome: R-HSA-174084;Reactome: R-HSA-8856828;Reactome: R-HSA-9013973;Reactome: R-HSA-69541;Reactome: R-HSA-450321;Reactome: R-HSA-9010553;Reactome: R-HSA-5693565;Reactome: R-HSA-162588;Reactome: R-HSA-5358346;Reactome: R-HSA-9645460;Reactome: R-HSA-2122947;Reactome: R-HSA-5610780;Reactome: R-HSA-2894862;Reactome: R-HSA-2467813;Reactome: R-HSA-5654727;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974 "IRAK2 mediated activation of TAK1 complex";"Negative regulation of MET activity";"Membrane binding and targetting of GAG proteins";"Regulation of FZD by ubiquitination";"Stimuli-sensing channels";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"GTP hydrolysis and joining of the 60S ribosomal subunit";"InlA-mediated entry of Listeria monocytogenes into host cells";"Peroxisomal protein import";"Hedgehog 'on' state";"Regulation of TP53 Degradation";"SCF-beta-TrCP mediated degradation of Emi1";"NOD1/2 Signaling Pathway";"Vpu mediated degradation of CD4";"APC/C:Cdc20 mediated degradation of Cyclin B";"Formation of TC-NER Pre-Incision Complex";"ISG15 antiviral mechanism";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Pink/Parkin Mediated Mitophagy";"Negative regulation of NOTCH4 signaling";"APC-Cdc20 mediated degradation of Nek2A";"Regulation of RAS by GAPs";"Termination of translesion DNA synthesis";"NRIF signals cell death from the nucleus";"activated TAK1 mediates p38 MAPK activation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Interleukin-1 signaling";"IKK complex recruitment mediated by RIP1";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Negative regulation of FGFR3 signaling";"Regulation of TP53 Activity through Phosphorylation";"SRP-dependent cotranslational protein targeting to membrane";"DNA Damage Recognition in GG-NER";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Formation of the ternary complex, and subsequently, the 43S complex";"Myoclonic epilepsy of Lafora";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"Deactivation of the beta-catenin transactivating complex";"Cargo recognition for clathrin-mediated endocytosis";"TICAM1, RIP1-mediated IKK complex recruitment";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Assembly Of The HIV Virion";"Regulation of RUNX2 expression and activity";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TCF dependent signaling in response to WNT";"Formation of a pool of free 40S subunits";"Orc1 removal from chromatin";"Prevention of phagosomal-lysosomal fusion";"Glycogen synthesis";"IRAK1 recruits IKK complex";"Downregulation of ERBB2:ERBB3 signaling";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Translesion Synthesis by POLH";"Circadian Clock";"UCH proteinases";"Regulation of TNFR1 signaling";"Downstream TCR signaling";"Aggrephagy";"L13a-mediated translational silencing of Ceruloplasmin expression";"EGFR downregulation";"Neddylation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of signaling by CBL";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Translesion synthesis by POLK";"G2/M Checkpoints";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"Regulation of TP53 Activity through Methylation";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Ovarian tumor domain proteases";"Endosomal Sorting Complex Required For Transport (ESCRT)";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Modulation by Mtb of host immune system";"Negative regulation of FGFR4 signaling";"Processing of DNA double-strand break ends";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Asymmetric localization of PCP proteins";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Late endosomal microautophagy";"Autodegradation of the E3 ubiquitin ligase COP1";"Gap-filling DNA repair synthesis and ligation in TC-NER";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Negative regulation of FGFR1 signaling";"Cyclin D associated events in G1";"Negative regulators of DDX58/IFIH1 signaling";"ABC-family proteins mediated transport";"Negative regulation of MAPK pathway";"APC/C:Cdc20 mediated degradation of Securin";"Translesion synthesis by POLI";"Senescence-Associated Secretory Phenotype (SASP)";"Downregulation of ERBB2 signaling";"Metalloprotease DUBs";"Regulation of PLK1 Activity at G2/M Transition";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Regulation of PTEN localization";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"p75NTR recruits signalling complexes";"Ub-specific processing proteases";"Oncogene Induced Senescence";"Downregulation of TGF-beta receptor signaling";"ER Quality Control Compartment (ERQC)";"Fanconi Anemia Pathway";"InlB-mediated entry of Listeria monocytogenes into host cell";"NF-kB is activated and signals survival";"Translesion synthesis by REV1";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"TNFR1-induced NFkappaB signaling pathway";"SCF(Skp2)-mediated degradation of p27/p21";"HDR through Homologous Recombination (HRR)";"Degradation of DVL";"Peptide chain elongation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Amyloid fiber formation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Activated NOTCH1 Transmits Signal to the Nucleus";"GLI3 is processed to GLI3R by the proteasome";"Selenocysteine synthesis";"Regulation of innate immune responses to cytosolic DNA";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Downregulation of ERBB4 signaling";"Regulation of necroptotic cell death";"Dual Incision in GG-NER";"Activation of NF-kappaB in B cells";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"Josephin domain DUBs";"Spry regulation of FGF signaling";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Viral mRNA Translation";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Regulation of PTEN stability and activity";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Recognition of DNA damage by PCNA-containing replication complex";"Degradation of AXIN";"Chaperone Mediated Autophagy";"Iron uptake and transport";"Ribosomal scanning and start codon recognition";"Oxidative Stress Induced Senescence";"E3 ubiquitin ligases ubiquitinate target proteins";"Autodegradation of Cdh1 by Cdh1:APC/C";"Clathrin-mediated endocytosis";"TICAM1-dependent activation of IRF3/IRF7";"Stabilization of p53";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Regulation of expression of SLITs and ROBOs";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Budding and maturation of HIV virion";"Hedgehog ligand biogenesis";"Alpha-protein kinase 1 signaling pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Degradation of GLI1 by the proteasome";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Separation of Sister Chromatids";"Negative regulation of FGFR2 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway" lcl|NW_020311343.1_prot_XP_020708743.1_4781 3 Reactome: R-HSA-983168;Reactome: R-HSA-6798695;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"Protein ubiquitination" lcl|NW_020311413.1_prot_XP_012254383.1_7909 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311499.1_prot_XP_012269262.1_9562 3 Reactome: R-HSA-5423646;Reactome: R-HSA-2142691;MetaCyc: PWY-7533 "Aflatoxin activation and detoxification";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis" lcl|NW_020311982.1_prot_XP_012258469.1_19229 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311956.1_prot_XP_020707542.1_12596 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311991.1_prot_XP_012269733.1_20923 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311457.1_prot_XP_012259311.1_9146 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311992.1_prot_XP_012266375.1_21053 4 MetaCyc: PWY-4841;Reactome: R-HSA-1855183;KEGG: 00562+1.13.99.1;KEGG: 00053+1.13.99.1 "UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)";"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Ascorbate and aldarate metabolism" lcl|NW_020311380.1_prot_XP_020711605.1_6660 1 Reactome: R-HSA-419771 "Opsins" lcl|NW_020311300.1_prot_XP_012253151.1_1504 7 Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-380284 "Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome" lcl|NW_020311988.1_prot_XP_020712201.1_20609 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" lcl|NW_020311984.1_prot_XP_012267663.1_20145 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311983.1_prot_XP_025602880.1_19543 6 Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311424.1_prot_XP_012255405.1_8223 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311981.1_prot_XP_012257448.1_18942 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" lcl|NW_020311993.1_prot_XP_012263196.1_21345 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311365.1_prot_XP_012269341.1_6009 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311978.1_prot_XP_012257828.1_18047 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311312.1_prot_XP_012266781.1_2599 11 Reactome: R-HSA-174437;Reactome: R-HSA-69166;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568;Reactome: R-HSA-69473;Reactome: R-HSA-5693579 "Removal of the Flap Intermediate from the C-strand";"Removal of the Flap Intermediate";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange" lcl|NW_020311966.1_prot_XP_012257322.1_14826 2 Reactome: R-HSA-5663220;Reactome: R-HSA-376176 "RHO GTPases Activate Formins";"Signaling by ROBO receptors" lcl|NW_020311332.1_prot_XP_012268535.1_4123 16 Reactome: R-HSA-3928665;Reactome: R-HSA-8866427;Reactome: R-HSA-8856828;Reactome: R-HSA-182218;Reactome: R-HSA-196025;Reactome: R-HSA-190873;Reactome: R-HSA-5099900;Reactome: R-HSA-8964038;Reactome: R-HSA-8856825;Reactome: R-HSA-177504;Reactome: R-HSA-164939;Reactome: R-HSA-416993;Reactome: R-HSA-5140745;Reactome: R-HSA-167590;Reactome: R-HSA-2132295;Reactome: R-HSA-437239 "EPH-ephrin mediated repulsion of cells";"VLDLR internalisation and degradation";"Clathrin-mediated endocytosis";"Nef Mediated CD8 Down-regulation";"Formation of annular gap junctions";"Gap junction degradation";"WNT5A-dependent internalization of FZD4";"LDL clearance";"Cargo recognition for clathrin-mediated endocytosis";"Retrograde neurotrophin signalling";"Nef mediated downregulation of CD28 cell surface expression";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Nef Mediated CD4 Down-regulation";"MHC class II antigen presentation";"Recycling pathway of L1" lcl|NW_020311417.1_prot_XP_025602034.1_7963 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" lcl|NW_020311974.1_prot_XP_012260004.1_16653 6 Reactome: R-HSA-181429;Reactome: R-HSA-181430;Reactome: R-HSA-210500;Reactome: R-HSA-264642;Reactome: R-HSA-212676;Reactome: R-HSA-388844 "Serotonin Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases" lcl|NW_020311417.1_prot_XP_025602036.1_7965 3 Reactome: R-HSA-445095;Reactome: R-HSA-8963901;Reactome: R-HSA-6807878 "Interaction between L1 and Ankyrins";"Chylomicron remodeling";"COPI-mediated anterograde transport" lcl|NW_020311961.1_prot_XP_012262529.1_13262 2 Reactome: R-HSA-8876198;Reactome: R-HSA-204005 "RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport" lcl|NW_020311365.1_prot_XP_020712485.1_5996 4 Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-2894862 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants" lcl|NW_020311932.1_prot_XP_012257413.1_10725 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311962.1_prot_XP_012251935.1_13687 2 Reactome: R-HSA-8876198;Reactome: R-HSA-6811436 "RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311980.1_prot_XP_012261379.1_18835 3 Reactome: R-HSA-8963684;KEGG: 00350+1.13.11.5;KEGG: 00643+1.13.11.5 "Tyrosine catabolism";"Tyrosine metabolism";"Styrene degradation" lcl|NW_020311982.1_prot_XP_012258309.1_19288 57 Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5689880;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-6798695;Reactome: R-HSA-349425;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-5607761;Reactome: R-HSA-174154 "Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of RAS by GAPs";"G2/M Checkpoints";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"Ub-specific processing proteases";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"Neutrophil degranulation";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin" lcl|NW_020311962.1_prot_XP_012252042.1_13568 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311401.1_prot_XP_020707829.1_7480 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" lcl|NW_020311946.1_prot_XP_020712321.1_11946 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311962.1_prot_XP_012251859.1_13581 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311397.1_prot_XP_012258201.1_7286 3 Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-936837 "Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Ion transport by P-type ATPases" lcl|NW_020311971.1_prot_XP_012260804.1_15854 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311961.1_prot_XP_012262522.1_13323 1 KEGG: 00970+6.1.1.20 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311448.1_prot_XP_012252699.1_8997 2 KEGG: 00230+1.7.1.7;Reactome: R-HSA-74217 "Purine metabolism";"Purine salvage" lcl|NW_020311918.1_prot_XP_012265046.1_10351 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311299.1_prot_XP_012263276.1_1436 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311947.1_prot_XP_012260662.1_11961 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311956.1_prot_XP_012251359.1_12638 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311443.1_prot_XP_020712022.1_8914 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" lcl|NW_020311317.1_prot_XP_012251557.1_3202 4 Reactome: R-HSA-983231;Reactome: R-HSA-1170546;Reactome: R-HSA-2586552;Reactome: R-HSA-982772 "Factors involved in megakaryocyte development and platelet production";"Prolactin receptor signaling";"Signaling by Leptin";"Growth hormone receptor signaling" lcl|NW_020311310.1_prot_XP_012255775.1_2426 13 Reactome: R-HSA-2132295;Reactome: R-HSA-8856825;Reactome: R-HSA-437239;Reactome: R-HSA-167590;Reactome: R-HSA-8964038;Reactome: R-HSA-5099900;Reactome: R-HSA-416993;Reactome: R-HSA-5140745;Reactome: R-HSA-182218;Reactome: R-HSA-8856828;Reactome: R-HSA-177504;Reactome: R-HSA-3928665;Reactome: R-HSA-8866427 "MHC class II antigen presentation";"Cargo recognition for clathrin-mediated endocytosis";"Recycling pathway of L1";"Nef Mediated CD4 Down-regulation";"LDL clearance";"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Nef Mediated CD8 Down-regulation";"Clathrin-mediated endocytosis";"Retrograde neurotrophin signalling";"EPH-ephrin mediated repulsion of cells";"VLDLR internalisation and degradation" lcl|NW_020311971.1_prot_XP_012263540.1_16089 12 Reactome: R-HSA-9609690;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295 "HCMV Early Events";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"COPI-mediated anterograde transport";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation" lcl|NW_020311966.1_prot_XP_012256730.1_14710 7 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-76071 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" lcl|NW_020311985.1_prot_XP_012265287.1_20264 4 Reactome: R-HSA-379716;MetaCyc: PWY-6281;Reactome: R-HSA-2408557;KEGG: 00970+6.1.1.11 "Cytosolic tRNA aminoacylation";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocysteine synthesis";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311962.1_prot_XP_020706694.1_13656 2 MetaCyc: PWY-6854;Reactome: R-HSA-3299685 "Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species" lcl|NW_020311966.1_prot_XP_012252935.1_14421 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311349.1_prot_XP_012251279.1_5248 5 Reactome: R-HSA-159231;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856 "Transport of Mature mRNA Derived from an Intronless Transcript";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination" lcl|NW_020311966.1_prot_XP_012256807.1_15006 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311987.1_prot_XP_012256502.1_20374 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311988.1_prot_XP_012261119.1_20726 2 Reactome: R-HSA-6791226;Reactome: R-HSA-8849473 "Major pathway of rRNA processing in the nucleolus and cytosol";"PTK6 Expression" lcl|NW_020311326.1_prot_XP_012261526.1_3729 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311982.1_prot_XP_012258410.1_19297 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" lcl|NW_020311992.1_prot_XP_012266531.1_21073 7 Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68827;Reactome: R-HSA-69205;Reactome: R-HSA-68689 "Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex";"G1/S-Specific Transcription";"CDC6 association with the ORC:origin complex" lcl|NW_020311976.1_prot_XP_012253666.1_17229 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311439.1_prot_XP_020710764.1_8849 2 Reactome: R-HSA-2151201;Reactome: R-HSA-400253 "Transcriptional activation of mitochondrial biogenesis";"Circadian Clock" lcl|NW_020311956.1_prot_XP_012254421.1_12594 6 Reactome: R-HSA-917977;Reactome: R-HSA-6798695;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556 "Transferrin endocytosis and recycling";"Neutrophil degranulation";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes" lcl|NW_020311995.1_prot_XP_012256763.1_21981 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311291.1_prot_XP_012259524.1_478 1 Reactome: R-HSA-211981 "Xenobiotics" lcl|NW_020311391.1_prot_XP_025601968.1_7053 3 Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482 "Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events" lcl|NW_020311977.1_prot_XP_012263907.1_17731 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311958.1_prot_XP_020708056.1_12986 13 Reactome: R-HSA-139853;Reactome: R-HSA-381676;Reactome: R-HSA-983695;Reactome: R-HSA-4086398;Reactome: R-HSA-5218921;Reactome: R-HSA-112043;Reactome: R-HSA-5578775;Reactome: R-HSA-2871809;Reactome: R-HSA-114508;Reactome: R-HSA-1489509;Reactome: R-HSA-422356;Reactome: R-HSA-2029485;Reactome: R-HSA-5607763 "Elevation of cytosolic Ca2+ levels";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Ca2+ pathway";"VEGFR2 mediated cell proliferation";"PLC beta mediated events";"Ion homeostasis";"FCERI mediated Ca+2 mobilization";"Effects of PIP2 hydrolysis";"DAG and IP3 signaling";"Regulation of insulin secretion";"Role of phospholipids in phagocytosis";"CLEC7A (Dectin-1) induces NFAT activation" lcl|NW_020311433.1_prot_XP_012264001.1_8614 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" lcl|NW_020311918.1_prot_XP_020710302.1_10304 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" lcl|NW_020311971.1_prot_XP_012260823.1_15844 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311959.1_prot_XP_020710139.1_13096 5 Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;MetaCyc: PWY-7268;MetaCyc: PWY-5083 "Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation" lcl|NW_020311948.1_prot_XP_020707160.1_12010 6 Reactome: R-HSA-8948216;Reactome: R-HSA-8874081;Reactome: R-HSA-1442490;Reactome: R-HSA-2022090;Reactome: R-HSA-3000171;Reactome: R-HSA-1650814 "Collagen chain trimerization";"MET activates PTK2 signaling";"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures";"Non-integrin membrane-ECM interactions";"Collagen biosynthesis and modifying enzymes" lcl|NW_020311327.1_prot_XP_012263360.1_3825 27 Reactome: R-HSA-3371453;Reactome: R-HSA-4570464;Reactome: R-HSA-3108214;Reactome: R-HSA-168271;Reactome: R-HSA-5619107;Reactome: R-HSA-159230;Reactome: R-HSA-168333;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-159227;Reactome: R-HSA-3301854;Reactome: R-HSA-180746;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-4615885;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-4551638;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-6784531 "Regulation of HSF1-mediated heat shock response";"SUMOylation of RNA binding proteins";"SUMOylation of DNA damage response and repair proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP Dependant Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"SUMOylation of DNA replication proteins";"HCMV Early Events";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of chromatin organization proteins";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"tRNA processing in the nucleus" lcl|NW_020311459.1_prot_XP_020709532.1_9167 18 MetaCyc: PWY-7417;MetaCyc: PWY-6803;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482922;Reactome: R-HSA-1483166;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;KEGG: 00564+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-1482839;Reactome: R-HSA-1482801;MetaCyc: PWY-8051;Reactome: R-HSA-1482925;MetaCyc: PWY-7783;MetaCyc: PWY-7409;MetaCyc: PWY-8053;Reactome: R-HSA-1482788 "Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidylcholine acyl editing";"Linoleic acid metabolism";"Acyl chain remodelling of PI";"Synthesis of PA";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PE";"Acyl chain remodelling of PS";"Anandamide biosynthesis I";"Acyl chain remodelling of PG";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PC" lcl|NW_020311978.1_prot_XP_012258000.1_18318 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311966.1_prot_XP_012251720.1_14578 19 MetaCyc: PWY-5913;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5172;MetaCyc: PWY-7384;Reactome: R-HSA-75105;Reactome: R-HSA-71403;Reactome: R-HSA-163765;MetaCyc: PWY-6969;MetaCyc: PWY-5538;KEGG: 00720+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-6728;MetaCyc: PWY-5392;Reactome: R-HSA-6798695;KEGG: 00020+2.3.3.8;MetaCyc: PWY-5537 "Partial TCA cycle (obligate autotrophs)";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Acetyl-coa biosynthesis III (from citrate)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Fatty acyl-CoA biosynthesis";"Citric acid cycle (TCA cycle)";"ChREBP activates metabolic gene expression";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Carbon fixation pathways in prokaryotes";"C5-Branched dibasic acid metabolism";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Reductive TCA cycle II";"Neutrophil degranulation";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate V" lcl|NW_020311981.1_prot_XP_020708479.1_18943 14 MetaCyc: PWY-3841;MetaCyc: PWY-3661-1;KEGG: 00680+2.1.2.1;MetaCyc: PWY-1622;Reactome: R-HSA-196757;MetaCyc: PWY-181;KEGG: 00260+2.1.2.1;KEGG: 00670+2.1.2.1;KEGG: 00460+2.1.2.1;MetaCyc: PWY-2201;MetaCyc: PWY-2161;MetaCyc: PWY-5497;MetaCyc: PWY-3661;KEGG: 00630+2.1.2.1 "Folate transformations II (plants)";"Glycine betaine degradation II (mammalian)";"Methane metabolism";"Formaldehyde assimilation I (serine pathway)";"Metabolism of folate and pterines";"Photorespiration ";"Glycine, serine and threonine metabolism";"One carbon pool by folate";"Cyanoamino acid metabolism";"Folate transformations I";"Folate polyglutamylation";"Purine nucleobases degradation II (anaerobic)";"Glycine betaine degradation I";"Glyoxylate and dicarboxylate metabolism" lcl|NW_020311401.1_prot_XP_012255125.1_7441 56 Reactome: R-HSA-5610780;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5689880;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902 "Degradation of GLI1 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"G2/M Checkpoints";"Regulation of RAS by GAPs";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Ub-specific processing proteases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity" lcl|NW_020311309.1_prot_XP_020709032.1_2405 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311419.1_prot_XP_012254049.1_8081 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" lcl|NW_020311966.1_prot_XP_020708303.1_15008 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311313.1_prot_XP_012261643.1_2903 3 Reactome: R-HSA-191859;Reactome: R-HSA-3214858;Reactome: R-HSA-6804760 "snRNP Assembly";"RMTs methylate histone arginines";"Regulation of TP53 Activity through Methylation" lcl|NW_020311940.1_prot_XP_012265647.1_11244 14 MetaCyc: PWY-7619;MetaCyc: PWY-5972;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-5080;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-7601;MetaCyc: PWY-7724;Reactome: R-HSA-75876 "Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs" lcl|NW_020311965.1_prot_XP_012259864.1_14184 2 KEGG: 00970+6.1.1.15;Reactome: R-HSA-379726 "Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" lcl|NW_020311940.1_prot_XP_025602373.1_11276 11 Reactome: R-HSA-163615;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;Reactome: R-HSA-418597;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-418594;Reactome: R-HSA-418555;Reactome: R-HSA-432040;Reactome: R-HSA-164378;Reactome: R-HSA-163359 "PKA activation";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"G alpha (z) signalling events";"Purine metabolism";"Adenylate cyclase activating pathway";"G alpha (i) signalling events";"G alpha (s) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation" lcl|NW_020311988.1_prot_XP_012269113.1_20585 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311973.1_prot_XP_012258627.1_16479 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311323.1_prot_XP_012268090.1_3489 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311312.1_prot_XP_012266758.1_2779 1 KEGG: 00970+6.1.1.20 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311619.1_prot_XP_020709575.1_10081 23 Reactome: R-HSA-428930;Reactome: R-HSA-418597;Reactome: R-HSA-202040;Reactome: R-HSA-418592;Reactome: R-HSA-381676;Reactome: R-HSA-418555;Reactome: R-HSA-500657;Reactome: R-HSA-9009391;Reactome: R-HSA-8964616;Reactome: R-HSA-392170;Reactome: R-HSA-400042;Reactome: R-HSA-418217;Reactome: R-HSA-420092;Reactome: R-HSA-392851;Reactome: R-HSA-392451;Reactome: R-HSA-8964315;Reactome: R-HSA-416476;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-4086398;Reactome: R-HSA-456926;Reactome: R-HSA-6814122;Reactome: R-HSA-416482 "Thromboxane signalling through TP receptor";"G alpha (z) signalling events";"G-protein activation";"ADP signalling through P2Y purinoceptor 1";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G alpha (s) signalling events";"Presynaptic function of Kainate receptors";"Extra-nuclear estrogen signaling";"G beta:gamma signalling through CDC42";"ADP signalling through P2Y purinoceptor 12";"Adrenaline,noradrenaline inhibits insulin secretion";"G beta:gamma signalling through PLC beta";"Glucagon-type ligand receptors";"Prostacyclin signalling through prostacyclin receptor";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through BTK";"G alpha (q) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Ca2+ pathway";"Thrombin signalling through proteinase activated receptors (PARs)";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (12/13) signalling events" lcl|NW_020311413.1_prot_XP_012254401.1_7905 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311966.1_prot_XP_025602594.1_15114 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" lcl|NW_020311994.1_prot_XP_012267367.1_21569 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.2 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311977.1_prot_XP_012253924.1_17504 1 Reactome: R-HSA-5649702 "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" lcl|NW_020311983.1_prot_XP_012255645.1_19790 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311982.1_prot_XP_012258238.1_19257 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311966.1_prot_XP_012251734.1_14581 5 Reactome: R-HSA-389661;MetaCyc: PWY-6853;Reactome: R-HSA-70688;KEGG: 00330+1.2.1.88;KEGG: 00250+1.2.1.88 "Glyoxylate metabolism and glycine degradation";"Ethylene biosynthesis II (microbes)";"Proline catabolism";"Arginine and proline metabolism";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311980.1_prot_XP_012261256.1_18800 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311940.1_prot_XP_012265652.1_11229 12 MetaCyc: PWY-8053;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783 "Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Plasmalogen degradation" lcl|NW_020311349.1_prot_XP_012262429.1_5161 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311446.1_prot_XP_012261108.1_8936 2 KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710 "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311332.1_prot_XP_020708077.1_4200 5 Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes" lcl|NW_020311310.1_prot_XP_012255808.2_2412 7 KEGG: 00983+2.7.4.14;Reactome: R-HSA-499943;KEGG: 00240+2.7.4.14;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7176;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3 "Drug metabolism - other enzymes";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine metabolism";"Thiamine metabolism";"UTP and CTP de novo biosynthesis";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311327.1_prot_XP_012252850.1_3765 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" lcl|NW_020311976.1_prot_XP_012257934.1_17372 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311290.1_prot_XP_012250907.1_432 1 Reactome: R-HSA-6804754 "Regulation of TP53 Expression" lcl|NW_020311964.1_prot_XP_012261679.1_14018 4 MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.32;KEGG: 00592+3.1.1.32 "Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism" lcl|NW_020311292.1_prot_XP_012252586.1_610 17 KEGG: 04926+2.7.11.1;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5685938;KEGG: 05165+2.7.11.1;Reactome: R-HSA-3371453;Reactome: R-HSA-69473;Reactome: R-HSA-1221632;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6796648;Reactome: R-HSA-6783310;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5693607 "Relaxin signaling pathway";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"HDR through Single Strand Annealing (SSA)";"Human papillomavirus infection";"Regulation of HSF1-mediated heat shock response";"G2/M DNA damage checkpoint";"Meiotic synapsis";"Thermogenesis";"Regulation of TP53 Activity through Phosphorylation";"mTOR signaling pathway";"TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway";"Human cytomegalovirus infection";"Processing of DNA double-strand break ends" lcl|NW_020311286.1_prot_XP_012256831.1_189 16 Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72649 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Translation initiation complex formation" lcl|NW_020311974.1_prot_XP_012260005.1_16654 6 Reactome: R-HSA-388844;Reactome: R-HSA-212676;Reactome: R-HSA-264642;Reactome: R-HSA-210500;Reactome: R-HSA-181430;Reactome: R-HSA-181429 "Receptor-type tyrosine-protein phosphatases";"Dopamine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle" lcl|NW_020311971.1_prot_XP_012263622.1_16035 5 Reactome: R-HSA-5694530;Reactome: R-HSA-204005;Reactome: R-HSA-983170;Reactome: R-HSA-1655829;Reactome: R-HSA-2132295 "Cargo concentration in the ER";"COPII-mediated vesicle transport";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"MHC class II antigen presentation" lcl|NW_020311333.1_prot_XP_012255937.1_4307 3 Reactome: R-HSA-174403;MetaCyc: PWY-7942;KEGG: 00480+4.3.2.7 "Glutathione synthesis and recycling";"5-oxo-L-proline metabolism";"Glutathione metabolism" lcl|NW_020311347.1_prot_XP_012265973.1_5037 10 KEGG: 00531+3.2.1.23;Reactome: R-HSA-2024096;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2160916;KEGG: 00052+3.2.1.23;Reactome: R-HSA-6798695;Reactome: R-HSA-2206292;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807 "Glycosaminoglycan degradation";"HS-GAG degradation";"Other glycan degradation";"Hyaluronan uptake and degradation";"Galactose metabolism";"Neutrophil degranulation";"MPS VII - Sly syndrome";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)" lcl|NW_020311966.1_prot_XP_012256281.1_14718 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311966.1_prot_XP_012256803.1_15197 4 MetaCyc: PWY-7887;Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+2.8.1.12 "Protein SAMPylation and SAMP-mediated thiolation";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis" lcl|NW_020311424.1_prot_XP_012255413.1_8199 2 Reactome: R-HSA-379716;Reactome: R-HSA-2408522 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism" lcl|NW_020311983.1_prot_XP_012255650.1_19724 12 Reactome: R-HSA-380270;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-2132295;Reactome: R-HSA-380284;Reactome: R-HSA-6807878;Reactome: R-HSA-5620912;Reactome: R-HSA-381038;Reactome: R-HSA-8854518 "Recruitment of mitotic centrosome proteins and complexes";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"MHC class II antigen presentation";"Loss of proteins required for interphase microtubule organization from the centrosome";"COPI-mediated anterograde transport";"Anchoring of the basal body to the plasma membrane";"XBP1(S) activates chaperone genes";"AURKA Activation by TPX2" lcl|NW_020311309.1_prot_XP_020709040.1_2353 2 Reactome: R-HSA-6807878;Reactome: R-HSA-6811434 "COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311983.1_prot_XP_020707887.1_19802 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311995.1_prot_XP_012257004.1_21960 3 Reactome: R-HSA-72165;Reactome: R-HSA-72163;Reactome: R-HSA-5250924 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway";"B-WICH complex positively regulates rRNA expression" lcl|NW_020311988.1_prot_XP_012254306.1_20470 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311973.1_prot_XP_012258645.1_16565 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" lcl|NW_020311975.1_prot_XP_020707585.1_17030 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311978.1_prot_XP_020708686.1_18320 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311981.1_prot_XP_012257457.1_19070 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311296.1_prot_XP_020711180.1_1000 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311974.1_prot_XP_012260049.1_16927 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311961.1_prot_XP_012262513.1_13316 2 KEGG: 00970+6.1.1.7;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" lcl|NW_020311380.1_prot_XP_020712077.1_6712 8 Reactome: R-HSA-8856828;Reactome: R-HSA-3928665;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-5140745;Reactome: R-HSA-432720;Reactome: R-HSA-5099900;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"Gap junction degradation";"Formation of annular gap junctions";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Lysosome Vesicle Biogenesis";"WNT5A-dependent internalization of FZD4";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311966.1_prot_XP_012257246.1_14864 2 Reactome: R-HSA-3214847;Reactome: R-HSA-427413 "HATs acetylate histones";"NoRC negatively regulates rRNA expression" lcl|NW_020311298.1_prot_XP_012269881.1_1323 3 Reactome: R-HSA-2024096;Reactome: R-HSA-2206296;Reactome: R-HSA-2024101 "HS-GAG degradation";"MPS II - Hunter syndrome";"CS/DS degradation" lcl|NW_020311994.1_prot_XP_020711905.1_21739 5 MetaCyc: PWY-7268;MetaCyc: PWY-5083;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7269 "NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)" lcl|NW_020311934.1_prot_XP_012255378.1_10822 2 KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20 "Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism" lcl|NW_020311974.1_prot_XP_012260012.1_16650 6 Reactome: R-HSA-388844;Reactome: R-HSA-212676;Reactome: R-HSA-264642;Reactome: R-HSA-210500;Reactome: R-HSA-181430;Reactome: R-HSA-181429 "Receptor-type tyrosine-protein phosphatases";"Dopamine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle" lcl|NW_020311981.1_prot_XP_012257455.1_19071 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311418.1_prot_XP_020709663.1_8021 3 Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300 "SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors" lcl|NW_020311943.1_prot_XP_020707665.1_11723 2 Reactome: R-HSA-375280;Reactome: R-HSA-416476 "Amine ligand-binding receptors";"G alpha (q) signalling events" lcl|NW_020311492.1_prot_XP_020711929.1_9490 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311377.1_prot_XP_020711607.1_6614 2 Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7 "Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311432.1_prot_XP_012268884.1_8493 6 Reactome: R-HSA-418597;Reactome: R-HSA-114516;KEGG: 04070+2.7.11.13;Reactome: R-HSA-416993;Reactome: R-HSA-76005;Reactome: R-HSA-5099900 "G alpha (z) signalling events";"Disinhibition of SNARE formation";"Phosphatidylinositol signaling system";"Trafficking of GluR2-containing AMPA receptors";"Response to elevated platelet cytosolic Ca2+";"WNT5A-dependent internalization of FZD4" lcl|NW_020311962.1_prot_XP_012252001.1_13704 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311988.1_prot_XP_012261208.1_20667 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311925.1_prot_XP_012265829.1_10570 1 Reactome: R-HSA-176974 "Unwinding of DNA" lcl|NW_020311977.1_prot_XP_012263957.1_18033 14 MetaCyc: PWY-5972;MetaCyc: PWY-7619;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-7724 "Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)" lcl|NW_020311959.1_prot_XP_012262295.1_13087 3 Reactome: R-HSA-6783310;Reactome: R-HSA-110314;Reactome: R-HSA-5689880 "Fanconi Anemia Pathway";"Recognition of DNA damage by PCNA-containing replication complex";"Ub-specific processing proteases" lcl|NW_020311983.1_prot_XP_020707936.1_19734 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" lcl|NW_020311976.1_prot_XP_012257691.1_17385 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311943.1_prot_XP_012255149.1_11639 3 KEGG: 00250+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00460+3.5.1.1 "Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism";"Cyanoamino acid metabolism" lcl|NW_020311349.1_prot_XP_012251150.1_5207 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311292.1_prot_XP_012252537.1_671 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" lcl|NW_020311377.1_prot_XP_012268460.1_6577 6 Reactome: R-HSA-8951430;Reactome: R-HSA-4411364;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-4086398 "RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"Ca2+ pathway" lcl|NW_020311974.1_prot_XP_012260164.1_16797 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311983.1_prot_XP_020707886.1_19801 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311362.1_prot_XP_012264954.1_5869 13 Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557 "Formation of a pool of free 40S subunits";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis" lcl|NW_020311943.1_prot_XP_020707843.1_11570 4 Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)" lcl|NW_020311498.1_prot_XP_012255048.1_9521 18 Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7221;MetaCyc: PWY-7184;MetaCyc: PWY-7227;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7176;MetaCyc: PWY-7198;MetaCyc: PWY-7187;MetaCyc: PWY-7210;MetaCyc: PWY-7205;MetaCyc: PWY-7220;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7226;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7224;MetaCyc: PWY-7197;MetaCyc: PWY-7222 "Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"CMP phosphorylation";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotide phosphorylation";"Guanosine deoxyribonucleotides de novo biosynthesis II" lcl|NW_020311418.1_prot_XP_012261022.1_8030 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311309.1_prot_XP_012259066.1_2252 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311984.1_prot_XP_020707564.1_19989 1 Reactome: R-HSA-901032 "ER Quality Control Compartment (ERQC)" lcl|NW_020311961.1_prot_XP_012262548.1_13513 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311324.1_prot_XP_020712508.1_3531 2 KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7 "Pyruvate metabolism";"Aminobenzoate degradation" lcl|NW_020311298.1_prot_XP_012250528.1_1355 8 Reactome: R-HSA-71336;KEGG: 00030+2.2.1.2;Reactome: R-HSA-6791055;Reactome: R-HSA-163754;MetaCyc: PWY-5723;MetaCyc: PWY-1861;Reactome: R-HSA-8950505;Reactome: R-HSA-6791462 "Pentose phosphate pathway";"Pentose phosphate pathway";"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P";"Insulin effects increased synthesis of Xylulose-5-Phosphate";"Rubisco shunt";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" lcl|NW_020311966.1_prot_XP_012252937.1_14422 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311971.1_prot_XP_025602662.1_15856 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311975.1_prot_XP_020707578.1_17031 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311965.1_prot_XP_012260311.1_14169 4 MetaCyc: PWY-6834;Reactome: R-HSA-351202;KEGG: 00270+4.1.1.50;KEGG: 00330+4.1.1.50 "Spermidine biosynthesis III";"Metabolism of polyamines";"Cysteine and methionine metabolism";"Arginine and proline metabolism" lcl|NW_020311751.1_prot_XP_025602241.1_10102 1 Reactome: R-HSA-1614603 "Cysteine formation from homocysteine" lcl|NW_020311349.1_prot_XP_012251227.1_5289 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311333.1_prot_XP_025601746.1_4290 4 Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311287.1_prot_XP_012268111.1_256 3 Reactome: R-HSA-418594;Reactome: R-HSA-375276;Reactome: R-HSA-416476 "G alpha (i) signalling events";"Peptide ligand-binding receptors";"G alpha (q) signalling events" lcl|NW_020311447.1_prot_XP_020706803.1_8964 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311972.1_prot_XP_012267821.1_16184 3 Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533 "Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis" lcl|NW_020311975.1_prot_XP_012253161.1_17143 18 MetaCyc: PWY-8053;MetaCyc: PWY-7409;Reactome: R-HSA-1482788;Reactome: R-HSA-1482801;MetaCyc: PWY-8051;Reactome: R-HSA-1482839;MetaCyc: PWY-7783;Reactome: R-HSA-1482925;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-6803;Reactome: R-HSA-1483166;Reactome: R-HSA-1482922;KEGG: 00591+3.1.1.4 "Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PC";"Acyl chain remodelling of PS";"Anandamide biosynthesis I";"Acyl chain remodelling of PE";"Plasmalogen degradation";"Acyl chain remodelling of PG";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidylcholine acyl editing";"Synthesis of PA";"Acyl chain remodelling of PI";"Linoleic acid metabolism" lcl|NW_020311984.1_prot_XP_012267786.1_20082 2 Reactome: R-HSA-8953750;Reactome: R-HSA-8939243 "Transcriptional Regulation by E2F6";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311302.1_prot_XP_020710858.1_1687 26 Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-5617833;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-389960;Reactome: R-HSA-9619483;Reactome: R-HSA-6807878;Reactome: R-HSA-389977;Reactome: R-HSA-1445148;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-380320;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-437239;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Cilium Assembly";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Formation of tubulin folding intermediates by CCT/TriC";"Activation of AMPK downstream of NMDARs";"COPI-mediated anterograde transport";"Post-chaperonin tubulin folding pathway";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"Recruitment of NuMA to mitotic centrosomes";"Separation of Sister Chromatids";"Aggrephagy";"RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Recycling pathway of L1";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation" lcl|NW_020311971.1_prot_XP_020710496.1_16121 2 Reactome: R-HSA-399719;Reactome: R-HSA-190873 "Trafficking of AMPA receptors";"Gap junction degradation" lcl|NW_020311919.1_prot_XP_012257625.1_10475 4 Reactome: R-HSA-379716;Reactome: R-HSA-2408522;KEGG: 00450+6.1.1.10;KEGG: 00970+6.1.1.10 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Selenocompound metabolism";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311315.1_prot_XP_020711119.1_3120 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311962.1_prot_XP_012251890.1_13605 3 Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-430039 "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311966.1_prot_XP_012256486.1_14873 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311984.1_prot_XP_012254627.1_20060 2 Reactome: R-HSA-418594;Reactome: R-HSA-6814122 "G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" lcl|NW_020311966.1_prot_XP_020708095.1_14800 1 Reactome: R-HSA-5689877 "Josephin domain DUBs" lcl|NW_020311977.1_prot_XP_012253854.1_17532 2 Reactome: R-HSA-201722;Reactome: R-HSA-171319 "Formation of the beta-catenin:TCF transactivating complex";"Telomere Extension By Telomerase" lcl|NW_020311365.1_prot_XP_012269337.1_5995 4 Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862 "NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants" lcl|NW_020311300.1_prot_XP_012253104.1_1480 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311286.1_prot_XP_025602279.1_78 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311940.1_prot_XP_020711283.1_11218 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311939.1_prot_XP_020706642.1_11070 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" lcl|NW_020311958.1_prot_XP_020707840.1_12929 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311966.1_prot_XP_012253700.1_14514 3 Reactome: R-HSA-8936459;Reactome: R-HSA-427413;Reactome: R-HSA-400206 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"NoRC negatively regulates rRNA expression";"Regulation of lipid metabolism by PPARalpha" lcl|NW_020311970.1_prot_XP_012269075.1_15610 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311977.1_prot_XP_012263778.1_17705 6 Reactome: R-HSA-196780;KEGG: 00780+6.3.4.15;KEGG: 00785+2.3.1.181;Reactome: R-HSA-3371599;MetaCyc: PWY-6987;MetaCyc: PWY-7382 "Biotin transport and metabolism";"Biotin metabolism";"Lipoic acid metabolism";"Defective HLCS causes multiple carboxylase deficiency";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoate biosynthesis and incorporation IV (yeast)" lcl|NW_020311961.1_prot_XP_012262587.1_13405 4 Reactome: R-HSA-186763;Reactome: R-HSA-428540;Reactome: R-HSA-373753;Reactome: R-HSA-4420097 "Downstream signal transduction";"Activation of RAC1";"Nephrin family interactions";"VEGFA-VEGFR2 Pathway" lcl|NW_020311965.1_prot_XP_012260083.1_14151 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311966.1_prot_XP_025602581.1_14535 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311292.1_prot_XP_012252495.1_504 1 Reactome: R-HSA-5689603 "UCH proteinases" lcl|NW_020311984.1_prot_XP_012254603.1_19913 1 Reactome: R-HSA-6785631 "ERBB2 Regulates Cell Motility" lcl|NW_020311312.1_prot_XP_012266938.1_2588 10 Reactome: R-HSA-2142789;MetaCyc: PWY-5844;MetaCyc: PWY-5890;MetaCyc: PWY-5839;MetaCyc: PWY-5891;MetaCyc: PWY-5892;MetaCyc: PWY-5849;KEGG: 00130+2.1.1.163;MetaCyc: PWY-5895;MetaCyc: PWY-7996 "Ubiquinol biosynthesis";"Menaquinol-9 biosynthesis";"Menaquinol-10 biosynthesis";"Menaquinol-7 biosynthesis";"Menaquinol-11 biosynthesis";"Menaquinol-12 biosynthesis";"Menaquinol-6 biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Menaquinol-13 biosynthesis";"Menaquinol-4 biosynthesis I" lcl|NW_020311393.1_prot_XP_020711297.1_7206 10 KEGG: 00010+2.7.1.11;MetaCyc: PWY-1042;KEGG: 00051+2.7.1.11;KEGG: 00680+2.7.1.11;MetaCyc: PWY-7385;KEGG: 00052+2.7.1.11;MetaCyc: PWY-5484;KEGG: 00030+2.7.1.11;MetaCyc: PWY-1861;Reactome: R-HSA-70171 "Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Fructose and mannose metabolism";"Methane metabolism";"1,3-propanediol biosynthesis (engineered)";"Galactose metabolism";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis" lcl|NW_020311408.1_prot_XP_012262142.1_7811 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311309.1_prot_XP_012259096.1_2391 11 MetaCyc: PWY-6549;MetaCyc: PWY-6963;KEGG: 00910+6.3.1.2;MetaCyc: PWY-381;KEGG: 00220+6.3.1.2;MetaCyc: PWY-6964;MetaCyc: PWY-5675;Reactome: R-HSA-8964539;Reactome: R-HSA-210455;KEGG: 00630+6.3.1.2;KEGG: 00250+6.3.1.2 "L-glutamine biosynthesis III";"Ammonia assimilation cycle I";"Nitrogen metabolism";"Nitrate reduction II (assimilatory)";"Arginine biosynthesis";"Ammonia assimilation cycle II";"Nitrate reduction V (assimilatory)";"Glutamate and glutamine metabolism";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Glyoxylate and dicarboxylate metabolism";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311966.1_prot_XP_012256415.1_15162 12 Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-6804756;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167152 "Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"Regulation of TP53 Activity through Phosphorylation";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of HIV elongation complex in the absence of HIV Tat" lcl|NW_020311292.1_prot_XP_020710257.1_679 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-112308;Reactome: R-HSA-5576893 "NCAM1 interactions";"Phase 0 - rapid depolarisation";"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase" lcl|NW_020311975.1_prot_XP_020707600.1_17035 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311314.1_prot_XP_020706759.1_3072 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311994.1_prot_XP_012267470.1_21737 5 MetaCyc: PWY-5083;MetaCyc: PWY-7268;Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269 "NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)" lcl|NW_020311373.1_prot_XP_012266727.1_6479 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311994.1_prot_XP_012267461.1_21789 2 KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753 "Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism" lcl|NW_020311297.1_prot_XP_012254106.1_1092 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311940.1_prot_XP_012265501.1_11234 6 MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782 "Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311333.1_prot_XP_012256147.1_4216 2 MetaCyc: PWY-6829;Reactome: R-HSA-6782315 "Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol" lcl|NW_020311982.1_prot_XP_020708735.1_19250 11 KEGG: 04151+2.7.11.1;Reactome: R-HSA-450302;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-2559580;Reactome: R-HSA-4420097;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-171007;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"activated TAK1 mediates p38 MAPK activation";"Human papillomavirus infection";"Human cytomegalovirus infection";"Oxidative Stress Induced Senescence";"VEGFA-VEGFR2 Pathway";"Relaxin signaling pathway";"Thermogenesis";"p38MAPK events";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311286.1_prot_XP_020708264.1_141 6 MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;Reactome: R-HSA-114508 "Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Effects of PIP2 hydrolysis" lcl|NW_020311369.1_prot_XP_020710745.1_6233 5 KEGG: 00740+2.7.1.26;MetaCyc: PWY-5523;Reactome: R-HSA-196843;MetaCyc: PWY-6168;MetaCyc: PWY-7863 "Riboflavin metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Vitamin B2 (riboflavin) metabolism";"Flavin biosynthesis III (fungi)";"Roseoflavin biosynthesis" lcl|NW_020311983.1_prot_XP_012255569.1_19657 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311317.1_prot_XP_012251013.1_3211 17 Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-6790901;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557 "Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"rRNA modification in the nucleus and cytosol";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis" lcl|NW_020311286.1_prot_XP_012256679.1_55 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection" lcl|NW_020311980.1_prot_XP_012254906.1_18705 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311446.1_prot_XP_012261110.1_8938 2 Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198 "Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis" lcl|NW_020311304.1_prot_XP_012260890.1_1767 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311499.1_prot_XP_012269263.1_9560 3 Reactome: R-HSA-5423646;Reactome: R-HSA-2142691;MetaCyc: PWY-7533 "Aflatoxin activation and detoxification";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis" lcl|NW_020311974.1_prot_XP_012260006.1_16647 6 Reactome: R-HSA-181429;Reactome: R-HSA-181430;Reactome: R-HSA-210500;Reactome: R-HSA-264642;Reactome: R-HSA-212676;Reactome: R-HSA-388844 "Serotonin Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases" lcl|NW_020311966.1_prot_XP_012256483.1_14872 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311976.1_prot_XP_012253527.1_17327 42 Reactome: R-HSA-5617472;Reactome: R-HSA-5625886;Reactome: R-HSA-5693565;Reactome: R-HSA-977225;Reactome: R-HSA-5578749;Reactome: R-HSA-3214842;Reactome: R-HSA-8936459;Reactome: R-HSA-2299718;Reactome: R-HSA-5693607;Reactome: R-HSA-5250924;Reactome: R-HSA-2559586;Reactome: R-HSA-3214847;Reactome: R-HSA-606279;Reactome: R-HSA-5334118;Reactome: R-HSA-73772;Reactome: R-HSA-110329;Reactome: R-HSA-1912408;Reactome: R-HSA-201722;Reactome: R-HSA-2559580;Reactome: R-HSA-9610379;Reactome: R-HSA-3214815;Reactome: R-HSA-212300;Reactome: R-HSA-73728;Reactome: R-HSA-1221632;Reactome: R-HSA-4551638;Reactome: R-HSA-912446;Reactome: R-HSA-5693571;Reactome: R-HSA-427413;Reactome: R-HSA-427389;Reactome: R-HSA-9616222;Reactome: R-HSA-3214841;Reactome: R-HSA-9609690;Reactome: R-HSA-3214858;Reactome: R-HSA-110330;Reactome: R-HSA-110328;Reactome: R-HSA-110331;Reactome: R-HSA-69473;Reactome: R-HSA-171306;Reactome: R-HSA-2559582;Reactome: R-HSA-9018519;Reactome: R-HSA-427359;Reactome: R-HSA-8939236 "Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Amyloid fiber formation";"Transcriptional regulation by small RNAs";"HDMs demethylate histones";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Condensation of Prophase Chromosomes";"Processing of DNA double-strand break ends";"B-WICH complex positively regulates rRNA expression";"DNA Damage/Telomere Stress Induced Senescence";"HATs acetylate histones";"Deposition of new CENPA-containing nucleosomes at the centromere";"DNA methylation";"RNA Polymerase I Promoter Escape";"Cleavage of the damaged pyrimidine";"Pre-NOTCH Transcription and Translation";"Formation of the beta-catenin:TCF transactivating complex";"Oxidative Stress Induced Senescence";"HCMV Late Events";"HDACs deacetylate histones";"PRC2 methylates histones and DNA";"RNA Polymerase I Promoter Opening";"Meiotic synapsis";"SUMOylation of chromatin organization proteins";"Meiotic recombination";"Nonhomologous End-Joining (NHEJ)";"NoRC negatively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Transcriptional regulation of granulopoiesis";"PKMTs methylate histone lysines";"HCMV Early Events";"RMTs methylate histone arginines";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged purine";"G2/M DNA damage checkpoint";"Packaging Of Telomere Ends";"Senescence-Associated Secretory Phenotype (SASP)";"Estrogen-dependent gene expression";"SIRT1 negatively regulates rRNA expression";"RUNX1 regulates transcription of genes involved in differentiation of HSCs" lcl|NW_020311983.1_prot_XP_012268333.1_19546 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311343.1_prot_XP_025601793.1_4764 12 KEGG: 04714+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-9619483;KEGG: 04926+2.7.11.1;Reactome: R-HSA-380972;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-1632852;KEGG: 04151+2.7.11.1 "Thermogenesis";"TP53 Regulates Metabolic Genes";"Activation of AMPK downstream of NMDARs";"Relaxin signaling pathway";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Human papillomavirus infection";"Macroautophagy";"PI3K-Akt signaling pathway" lcl|NW_020311432.1_prot_XP_020712261.1_8506 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" lcl|NW_020311397.1_prot_XP_012258196.1_7298 3 Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311961.1_prot_XP_012262748.1_13351 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311989.1_prot_XP_012263189.1_20774 12 MetaCyc: PWY-5855;MetaCyc: PWY-6708;MetaCyc: PWY-5873;MetaCyc: PWY-5857;KEGG: 00130+2.5.1.39;Reactome: R-HSA-1268020;MetaCyc: PWY-5871;MetaCyc: PWY-5872;MetaCyc: PWY-5856;MetaCyc: PWY-5870;MetaCyc: PWY-6978;Reactome: R-HSA-2142789 "Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Mitochondrial protein import";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol biosynthesis" lcl|NW_020311966.1_prot_XP_012256764.1_15188 3 Reactome: R-HSA-8963684;Reactome: R-HSA-156590;Reactome: R-HSA-204174 "Tyrosine catabolism";"Glutathione conjugation";"Regulation of pyruvate dehydrogenase (PDH) complex" lcl|NW_020311966.1_prot_XP_012256750.1_15084 7 MetaCyc: PWY-7456;KEGG: 00051+5.4.2.8;Reactome: R-HSA-446205;MetaCyc: PWY-882;MetaCyc: PWY-5659;MetaCyc: PWY-7586;KEGG: 00520+5.4.2.8 "Beta-(1,4)-mannan degradation";"Fructose and mannose metabolism";"Synthesis of GDP-mannose";"L-ascorbate biosynthesis I (L-galactose pathway)";"GDP-mannose biosynthesis";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311300.1_prot_XP_012253230.1_1589 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311989.1_prot_XP_012263273.1_20744 2 Reactome: R-HSA-917729;Reactome: R-HSA-9610379 "Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events" lcl|NW_020311974.1_prot_XP_020709281.1_16915 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" lcl|NW_020311339.1_prot_XP_012252264.1_4605 2 Reactome: R-HSA-6783310;Reactome: R-HSA-6796648 "Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes" lcl|NW_020311287.1_prot_XP_020711794.1_258 4 MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-6483 "Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide degradation (generic)" lcl|NW_020311286.1_prot_XP_012256440.1_227 5 KEGG: 00520+2.7.1.6;MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6317;MetaCyc: PWY-6527 "Amino sugar and nucleotide sugar metabolism";"D-galactose detoxification";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation" lcl|NW_020311978.1_prot_XP_012258033.1_18479 52 Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-349425;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-9010553;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-4641257 "SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Regulation of expression of SLITs and ROBOs";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of RAS by GAPs";"G2/M Checkpoints";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN" lcl|NW_020311976.1_prot_XP_012256987.1_17395 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311393.1_prot_XP_012265777.1_7205 10 KEGG: 00051+2.7.1.11;KEGG: 00010+2.7.1.11;MetaCyc: PWY-1042;KEGG: 00030+2.7.1.11;MetaCyc: PWY-5484;Reactome: R-HSA-70171;MetaCyc: PWY-1861;MetaCyc: PWY-7385;KEGG: 00680+2.7.1.11;KEGG: 00052+2.7.1.11 "Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism";"Galactose metabolism" lcl|NW_020311396.1_prot_XP_025601981.1_7269 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311360.1_prot_XP_020706626.1_5738 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311958.1_prot_XP_020708046.1_12992 13 Reactome: R-HSA-139853;Reactome: R-HSA-381676;Reactome: R-HSA-4086398;Reactome: R-HSA-983695;Reactome: R-HSA-5218921;Reactome: R-HSA-112043;Reactome: R-HSA-114508;Reactome: R-HSA-1489509;Reactome: R-HSA-5578775;Reactome: R-HSA-2871809;Reactome: R-HSA-422356;Reactome: R-HSA-2029485;Reactome: R-HSA-5607763 "Elevation of cytosolic Ca2+ levels";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Ca2+ pathway";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"VEGFR2 mediated cell proliferation";"PLC beta mediated events";"Effects of PIP2 hydrolysis";"DAG and IP3 signaling";"Ion homeostasis";"FCERI mediated Ca+2 mobilization";"Regulation of insulin secretion";"Role of phospholipids in phagocytosis";"CLEC7A (Dectin-1) induces NFAT activation" lcl|NW_020311313.1_prot_XP_012261832.1_3029 1 Reactome: R-HSA-176974 "Unwinding of DNA" lcl|NW_020311477.1_prot_XP_020710085.1_9427 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311984.1_prot_XP_012254553.1_19936 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311285.1_prot_XP_012256114.1_35 3 KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361;MetaCyc: PWY-7174 "Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II" lcl|NW_020311943.1_prot_XP_020707701.1_11654 5 Reactome: R-HSA-189085;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;MetaCyc: PWY-6902 "Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)" lcl|NW_020311981.1_prot_XP_012257399.1_19024 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311513.1_prot_XP_012266091.1_9879 2 Reactome: R-HSA-8862803;Reactome: R-HSA-69273 "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Cyclin A/B1/B2 associated events during G2/M transition" lcl|NW_020311943.1_prot_XP_020707842.1_11574 1 Reactome: R-HSA-196819 "Vitamin B1 (thiamin) metabolism" lcl|NW_020311300.1_prot_XP_012253146.1_1501 7 Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-380284 "Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome" lcl|NW_020311513.1_prot_XP_012266041.1_9771 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311959.1_prot_XP_020709510.1_13031 2 Reactome: R-HSA-6807878;Reactome: R-HSA-445095 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins" lcl|NW_020311418.1_prot_XP_012261052.1_8022 3 Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300 "SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors" lcl|NW_020311397.1_prot_XP_012258188.1_7291 3 Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" lcl|NW_020311940.1_prot_XP_012252772.1_11112 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311977.1_prot_XP_020710546.1_17772 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311334.1_prot_XP_025601752.1_4344 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311966.1_prot_XP_012256875.1_15167 20 KEGG: 00640+1.3.3.6;MetaCyc: PWY-7007;Reactome: R-HSA-9033241;MetaCyc: PWY-735;MetaCyc: PWY-7338;MetaCyc: PWY-7574;MetaCyc: PWY-7854;MetaCyc: PWY-7606;MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7337;MetaCyc: PWY-7291;KEGG: 00592+1.3.3.6;MetaCyc: PWY-6837;MetaCyc: PWY-7858;KEGG: 00410+1.3.3.6;MetaCyc: PWY-6920;MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7726 "Propanoate metabolism";"Methyl ketone biosynthesis (engineered)";"Peroxisomal protein import";"Jasmonic acid biosynthesis";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoyl-coa degradation II";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"(5Z)-dodecenoate biosynthesis II";"beta-Alanine metabolism";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)" lcl|NW_020311365.1_prot_XP_012269334.1_5992 4 Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription" lcl|NW_020311312.1_prot_XP_012266761.1_2686 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311940.1_prot_XP_012265684.1_11238 3 Reactome: R-HSA-379726;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.14 "Mitochondrial tRNA aminoacylation";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311298.1_prot_XP_012269905.1_1213 3 KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154 "Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase" lcl|NW_020311313.1_prot_XP_012261866.1_2895 2 Reactome: R-HSA-428890;KEGG: 04660+2.7.10.2 "Role of ABL in ROBO-SLIT signaling";"T cell receptor signaling pathway" lcl|NW_020311995.1_prot_XP_012256267.1_21895 3 MetaCyc: PWY-6700;Reactome: R-HSA-6782315;MetaCyc: PWY-8106 "Queuosine biosynthesis I (de novo)";"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis III (queuosine salvage)" lcl|NW_020311980.1_prot_XP_020709754.1_18778 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311958.1_prot_XP_012255616.1_12937 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311977.1_prot_XP_012263920.1_17860 6 MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463 "Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis" lcl|NW_020311972.1_prot_XP_012264671.1_16304 7 Reactome: R-HSA-1538133;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-156711 "G0 and Early G1";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"Polo-like kinase mediated events" lcl|NW_020311297.1_prot_XP_012254111.1_1109 8 Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68616;Reactome: R-HSA-68867 "Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex" lcl|NW_020311313.1_prot_XP_012261682.1_2926 17 Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-174437;Reactome: R-HSA-110314;Reactome: R-HSA-5358606;Reactome: R-HSA-69091;Reactome: R-HSA-174411;Reactome: R-HSA-5685942;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801;Reactome: R-HSA-69183;Reactome: R-HSA-69166;Reactome: R-HSA-174414;Reactome: R-HSA-5696397;Reactome: R-HSA-5696400;Reactome: R-HSA-5358565;Reactome: R-HSA-174417 "Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Removal of the Flap Intermediate from the C-strand";"Recognition of DNA damage by PCNA-containing replication complex";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Polymerase switching";"Polymerase switching on the C-strand of the telomere";"HDR through Homologous Recombination (HRR)";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate";"Processive synthesis on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Dual Incision in GG-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Telomere C-strand (Lagging Strand) Synthesis" lcl|NW_020311966.1_prot_XP_012252988.1_14529 1 Reactome: R-HSA-373752 "Netrin-1 signaling" lcl|NW_020311975.1_prot_XP_020707589.1_17028 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311977.1_prot_XP_020710541.1_18028 14 MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7725 "Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)" lcl|NW_020311970.1_prot_XP_012267503.1_15783 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" lcl|NW_020311932.1_prot_XP_012253018.1_10695 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" lcl|NW_020311365.1_prot_XP_020712481.1_5987 4 Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" lcl|NW_020311291.1_prot_XP_012259659.1_461 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" lcl|NW_020311937.1_prot_XP_012252639.1_11042 16 Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557 "Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis" lcl|NW_020311294.1_prot_XP_020710992.2_890 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311995.1_prot_XP_012256700.1_21917 1 Reactome: R-HSA-5693607 "Processing of DNA double-strand break ends" lcl|NW_020311937.1_prot_XP_020706894.1_11026 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311969.1_prot_XP_020710965.1_15558 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection" lcl|NW_020311984.1_prot_XP_012264710.1_19822 8 KEGG: 00010+1.1.1.27;MetaCyc: PWY-5481;KEGG: 00640+1.1.1.27;MetaCyc: PWY-6901;Reactome: R-HSA-70268;KEGG: 00270+1.1.1.27;KEGG: 00620+1.1.1.27;MetaCyc: PWY-8086 "Glycolysis / Gluconeogenesis";"Pyruvate fermentation to (S)-lactate";"Propanoate metabolism";"Superpathway of glucose and xylose degradation";"Pyruvate metabolism";"Cysteine and methionine metabolism";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen" lcl|NW_020311969.1_prot_XP_012264805.1_15522 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" lcl|NW_020311407.1_prot_XP_020707775.1_7783 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311433.1_prot_XP_012263839.1_8655 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" lcl|NW_020311313.1_prot_XP_025603061.1_2801 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311330.1_prot_XP_012267983.1_4051 24 Reactome: R-HSA-114604;Reactome: R-HSA-9634635;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5607764;Reactome: R-HSA-392451;Reactome: R-HSA-354192;Reactome: R-HSA-5625740;KEGG: 04151+2.7.11.1;Reactome: R-HSA-444257;KEGG: 04714+2.7.11.1;Reactome: R-HSA-165158;Reactome: R-HSA-6804757;Reactome: R-HSA-1257604;Reactome: R-HSA-5218921;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5218920;Reactome: R-HSA-2871837;Reactome: R-HSA-5674400;Reactome: R-HSA-389357;Reactome: R-HSA-2730905;Reactome: R-HSA-202424 "GPVI-mediated activation cascade";"Estrogen-stimulated signaling through PRKCZ";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"CLEC7A (Dectin-1) signaling";"G beta:gamma signalling through PI3Kgamma";"Integrin signaling";"RHO GTPases activate PKNs";"PI3K-Akt signaling pathway";"RSK activation";"Thermogenesis";"Activation of AKT2";"Regulation of TP53 Degradation";"PIP3 activates AKT signaling";"VEGFR2 mediated cell proliferation";"mTOR signaling pathway";"Human cytomegalovirus infection";"VEGFR2 mediated vascular permeability";"FCERI mediated NF-kB activation";"Constitutive Signaling by AKT1 E17K in Cancer";"CD28 dependent PI3K/Akt signaling";"Role of LAT2/NTAL/LAB on calcium mobilization";"Downstream TCR signaling" lcl|NW_020311432.1_prot_XP_012268674.1_8389 1 Reactome: R-HSA-373753 "Nephrin family interactions" lcl|NW_020311462.1_prot_XP_012252270.1_9218 4 Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-983712 "Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Ion channel transport" lcl|NW_020311957.1_prot_XP_012263342.1_12886 5 Reactome: R-HSA-5620922;Reactome: R-HSA-5632684;Reactome: R-HSA-373080;Reactome: R-HSA-5635838;Reactome: R-HSA-5610787 "BBSome-mediated cargo-targeting to cilium";"Hedgehog 'on' state";"Class B/2 (Secretin family receptors)";"Activation of SMO";"Hedgehog 'off' state" lcl|NW_020311316.1_prot_XP_020712357.1_3153 7 KEGG: 00250+4.3.2.2;KEGG: 00230+4.3.2.2;MetaCyc: PWY-7234;Reactome: R-HSA-73817;MetaCyc: PWY-6123;MetaCyc: PWY-7219;MetaCyc: PWY-6124 "Alanine, aspartate and glutamate metabolism";"Purine metabolism";"Inosine-5'-phosphate biosynthesis III";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis I";"Adenosine ribonucleotides de novo biosynthesis";"Inosine-5'-phosphate biosynthesis II" lcl|NW_020311943.1_prot_XP_012254979.1_11665 3 Reactome: R-HSA-977347;KEGG: 00680+3.1.3.3;KEGG: 00260+3.1.3.3 "Serine biosynthesis";"Methane metabolism";"Glycine, serine and threonine metabolism" lcl|NW_020311325.1_prot_XP_020711707.1_3656 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311965.1_prot_XP_012260340.1_14155 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311962.1_prot_XP_012251946.1_13636 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311974.1_prot_XP_012260010.1_16646 6 Reactome: R-HSA-388844;Reactome: R-HSA-212676;Reactome: R-HSA-264642;Reactome: R-HSA-210500;Reactome: R-HSA-181430;Reactome: R-HSA-181429 "Receptor-type tyrosine-protein phosphatases";"Dopamine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle" lcl|NW_020311324.1_prot_XP_012269362.1_3567 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311955.1_prot_XP_020711159.1_12462 5 Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379;Reactome: R-HSA-9615710;Reactome: R-HSA-174490 "Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events";"Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins" lcl|NW_020311432.1_prot_XP_020712198.1_8320 1 Reactome: R-HSA-71403 "Citric acid cycle (TCA cycle)" lcl|NW_020311955.1_prot_XP_020711145.1_12383 10 KEGG: 00052+5.1.3.2;MetaCyc: PWY-7344;KEGG: 00520+5.1.3.2;MetaCyc: PWY-6527;Reactome: R-HSA-5609977;MetaCyc: PWY-6317;MetaCyc: PWY-6397;Reactome: R-HSA-70370;MetaCyc: PWY-3821;MetaCyc: PWY-7328 "Galactose metabolism";"UDP-alpha-D-galactose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose degradation I (Leloir pathway)";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Galactose catabolism";"D-galactose detoxification";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis" lcl|NW_020311971.1_prot_XP_012263519.1_16050 56 Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-187577;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684 "Regulation of RAS by GAPs";"G2/M Checkpoints";"SCF(Skp2)-mediated degradation of p27/p21";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state" lcl|NW_020311936.1_prot_XP_025602326.1_10991 5 Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2559580;Reactome: R-HSA-450321;Reactome: R-HSA-2871796 "Activation of the AP-1 family of transcription factors";"mTOR signaling pathway";"Oxidative Stress Induced Senescence";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"FCERI mediated MAPK activation" lcl|NW_020311418.1_prot_XP_012261035.1_7989 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311992.1_prot_XP_012266312.1_21276 14 MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-6803;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7409 "Plasmalogen degradation";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Ether lipid metabolism";"Retinoid metabolism and transport";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)" lcl|NW_020311313.1_prot_XP_012261644.1_2904 3 Reactome: R-HSA-191859;Reactome: R-HSA-6804760;Reactome: R-HSA-3214858 "snRNP Assembly";"Regulation of TP53 Activity through Methylation";"RMTs methylate histone arginines" lcl|NW_020311424.1_prot_XP_020707850.1_8196 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311953.1_prot_XP_020709490.1_12269 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311992.1_prot_XP_012266311.1_21275 14 KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1482788;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;MetaCyc: PWY-8053;MetaCyc: PWY-7409 "Linoleic acid metabolism";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Acyl chain remodelling of PC";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Retinoid metabolism and transport";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)" lcl|NW_020311966.1_prot_XP_012253680.1_14506 4 KEGG: 00500+3.1.3.9;KEGG: 00010+3.1.3.9;KEGG: 00052+3.1.3.9;Reactome: R-HSA-70263 "Starch and sucrose metabolism";"Glycolysis / Gluconeogenesis";"Galactose metabolism";"Gluconeogenesis" lcl|NW_020311978.1_prot_XP_012257912.1_18417 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311974.1_prot_XP_012260297.1_16794 8 KEGG: 00195+7.1.2.2;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980 "Photosynthesis";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Ion channel transport";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Oxidative phosphorylation";"ATP biosynthesis" lcl|NW_020311946.1_prot_XP_012268572.1_11877 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311970.1_prot_XP_025602644.1_15650 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311299.1_prot_XP_012263166.1_1437 3 Reactome: R-HSA-194313;Reactome: R-HSA-114608;Reactome: R-HSA-195399 "VEGF ligand-receptor interactions";"Platelet degranulation";"VEGF binds to VEGFR leading to receptor dimerization" lcl|NW_020311975.1_prot_XP_020706542.1_17008 14 MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7411;MetaCyc: PWY-5981;MetaCyc: PWY-7589;MetaCyc: PWY-6453;MetaCyc: PWY-7417;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-5667 "Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I" lcl|NW_020311300.1_prot_XP_020707117.1_1491 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311349.1_prot_XP_020706494.1_5228 7 Reactome: R-HSA-5628897;KEGG: 00250+3.5.1.2;Reactome: R-HSA-210500;KEGG: 00471+3.5.1.2;MetaCyc: PWY-5921;Reactome: R-HSA-8964539;KEGG: 00220+3.5.1.2 "TP53 Regulates Metabolic Genes";"Alanine, aspartate and glutamate metabolism";"Glutamate Neurotransmitter Release Cycle";"D-Glutamine and D-glutamate metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate and glutamine metabolism";"Arginine biosynthesis" lcl|NW_020311968.1_prot_XP_012253080.1_15424 11 Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-400206;Reactome: R-HSA-3214858;Reactome: R-HSA-1368082;Reactome: R-HSA-2426168;Reactome: R-HSA-9018519;Reactome: R-HSA-2151201;Reactome: R-HSA-6804114;Reactome: R-HSA-1368108 "Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"RMTs methylate histone arginines";"RORA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"Estrogen-dependent gene expression";"Transcriptional activation of mitochondrial biogenesis";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"BMAL1:CLOCK,NPAS2 activates circadian gene expression" lcl|NW_020311426.1_prot_XP_012268555.1_8249 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311373.1_prot_XP_020711633.1_6441 14 Reactome: R-HSA-5656121;Reactome: R-HSA-5696400;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-5685942;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-5655862;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-69091;Reactome: R-HSA-110320 "Translesion synthesis by POLI";"Dual Incision in GG-NER";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"HDR through Homologous Recombination (HRR)";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Translesion synthesis by POLK";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Polymerase switching";"Translesion Synthesis by POLH" lcl|NW_020311966.1_prot_XP_012253007.1_14392 6 KEGG: 00030+5.1.3.1;KEGG: 00710+5.1.3.1;Reactome: R-HSA-71336;MetaCyc: PWY-1861;KEGG: 00040+5.1.3.1;MetaCyc: PWY-5723 "Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose and glucuronate interconversions";"Rubisco shunt" lcl|NW_020311976.1_prot_XP_012257001.1_17394 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311959.1_prot_XP_012262301.1_13088 3 MetaCyc: PWY-6689;Reactome: R-HSA-6784531;MetaCyc: PWY-7803 "Trna splicing I";"tRNA processing in the nucleus";"Trna splicing II" lcl|NW_020311971.1_prot_XP_012263581.1_16120 12 Reactome: R-HSA-1442490;Reactome: R-HSA-75893;Reactome: R-HSA-982772;Reactome: R-HSA-2894862;Reactome: R-HSA-2660826;Reactome: R-HSA-2644606;Reactome: R-HSA-193692;Reactome: R-HSA-5362798;Reactome: R-HSA-1251985;Reactome: R-HSA-177929;Reactome: R-HSA-2691232;Reactome: R-HSA-2122948 "Collagen degradation";"TNF signaling";"Growth hormone receptor signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulated proteolysis of p75NTR";"Release of Hh-Np from the secreting cell";"Nuclear signaling by ERBB4";"Signaling by EGFR";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus" lcl|NW_020311955.1_prot_XP_012265481.1_12434 6 Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-6791226 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311977.1_prot_XP_012253852.1_17566 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311978.1_prot_XP_020708561.1_18401 7 Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;MetaCyc: PWY-7511;Reactome: R-HSA-2691232;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948 "NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus" lcl|NW_020311957.1_prot_XP_012262074.1_12753 4 Reactome: R-HSA-73817;MetaCyc: PWY-7221;KEGG: 00230+6.3.5.2;KEGG: 00983+6.3.5.2 "Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Drug metabolism - other enzymes" lcl|NW_020311419.1_prot_XP_012254052.1_8084 5 MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109 "Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis" lcl|NW_020311961.1_prot_XP_012262527.1_13261 2 Reactome: R-HSA-8876198;Reactome: R-HSA-204005 "RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport" lcl|NW_020311947.1_prot_XP_012260640.1_11949 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311356.1_prot_XP_012267060.1_5562 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" lcl|NW_020311367.1_prot_XP_012262760.1_6185 2 KEGG: 00450+2.7.9.3;MetaCyc: PWY-6281 "Selenocompound metabolism";"L-selenocysteine biosynthesis II (archaea and eukaryotes)" lcl|NW_020311310.1_prot_XP_012255805.1_2442 14 KEGG: 00290+2.6.1.42;MetaCyc: PWY-5108;MetaCyc: PWY-5057;MetaCyc: PWY-5076;Reactome: R-HSA-70895;KEGG: 00770+2.6.1.42;MetaCyc: PWY-5101;KEGG: 00280+2.6.1.42;MetaCyc: PWY-7767;MetaCyc: PWY-5104;MetaCyc: PWY-5103;KEGG: 00270+2.6.1.42;KEGG: 00966+2.6.1.42;MetaCyc: PWY-5078 "Valine, leucine and isoleucine biosynthesis";"L-isoleucine biosynthesis V";"L-valine degradation II";"L-leucine degradation III";"Branched-chain amino acid catabolism";"Pantothenate and CoA biosynthesis";"L-isoleucine biosynthesis II";"Valine, leucine and isoleucine degradation";"L-leucine degradation IV (Stickland reaction)";"L-isoleucine biosynthesis IV";"L-isoleucine biosynthesis III";"Cysteine and methionine metabolism";"Glucosinolate biosynthesis";"L-isoleucine degradation II" lcl|NW_020311988.1_prot_XP_025602940.1_20738 14 MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-8041;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7602;KEGG: 00062+2.3.1.199 "Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Fatty acid elongation" lcl|NW_020311381.1_prot_XP_012252344.1_6842 56 Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-5687128;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902 "Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"G2/M Checkpoints";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"MAPK6/MAPK4 signaling";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity" lcl|NW_020311965.1_prot_XP_020709162.1_14387 4 Reactome: R-HSA-6787450;KEGG: 00908+2.5.1.75;Reactome: R-HSA-6782315;MetaCyc: PWY-2781 "tRNA modification in the mitochondrion";"Zeatin biosynthesis";"tRNA modification in the nucleus and cytosol";"Cis-zeatin biosynthesis" lcl|NW_020311292.1_prot_XP_012252513.1_583 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311286.1_prot_XP_012256424.1_218 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311937.1_prot_XP_012252636.1_11035 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" lcl|NW_020311403.1_prot_XP_012258442.1_7744 16 KEGG: 00020+6.2.1.4;MetaCyc: PWY-5538;MetaCyc: PWY-6969;MetaCyc: PWY-5690;MetaCyc: PWY-6728;MetaCyc: PWY-5392;KEGG: 00720+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5537;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-5749;KEGG: 00640+6.2.1.4;Reactome: R-HSA-71403;MetaCyc: PWY-7384 "Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"C5-Branched dibasic acid metabolism";"Pyruvate fermentation to acetate V";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Itaconate degradation";"Propanoate metabolism";"Citric acid cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)" lcl|NW_020311945.1_prot_XP_012269658.1_11815 13 KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;KEGG: 00720+6.3.4.3;MetaCyc: PWY-5030;Reactome: R-HSA-196757;MetaCyc: PWY-1722;KEGG: 00670+6.3.4.3;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-7909;MetaCyc: PWY-2161;MetaCyc: PWY-2201;MetaCyc: PWY-6613;MetaCyc: PWY-5497 "Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"L-histidine degradation III";"Metabolism of folate and pterines";"Formate assimilation into 5,10-methylenetetrahydrofolate";"One carbon pool by folate";"One carbon pool by folate";"Formaldehyde oxidation VII (THF pathway)";"Folate polyglutamylation";"Folate transformations I";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine nucleobases degradation II (anaerobic)" lcl|NW_020311961.1_prot_XP_012262741.1_13299 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" lcl|NW_020311973.1_prot_XP_012258527.1_16635 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311334.1_prot_XP_012265919.1_4369 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311978.1_prot_XP_025602776.1_18041 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311966.1_prot_XP_012251721.1_14579 19 Reactome: R-HSA-163765;Reactome: R-HSA-71403;Reactome: R-HSA-75105;MetaCyc: PWY-7384;MetaCyc: PWY-5172;KEGG: 00720+2.3.3.8;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-5537;KEGG: 00020+2.3.3.8;MetaCyc: PWY-6728;MetaCyc: PWY-5690;Reactome: R-HSA-6798695;MetaCyc: PWY-5392;KEGG: 00720+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5538;MetaCyc: PWY-6969 "ChREBP activates metabolic gene expression";"Citric acid cycle (TCA cycle)";"Fatty acyl-CoA biosynthesis";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Acetyl-coa biosynthesis III (from citrate)";"Carbon fixation pathways in prokaryotes";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Pyruvate fermentation to acetate V";"Citrate cycle (TCA cycle)";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Neutrophil degranulation";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"C5-Branched dibasic acid metabolism";"Pyruvate fermentation to acetate VI";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)" lcl|NW_020311983.1_prot_XP_012268317.1_19614 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311380.1_prot_XP_012268178.2_6692 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" lcl|NW_020311339.1_prot_XP_012252104.1_4629 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311329.1_prot_XP_020706136.1_3971 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311995.1_prot_XP_012256269.1_21897 3 MetaCyc: PWY-6700;Reactome: R-HSA-6782315;MetaCyc: PWY-8106 "Queuosine biosynthesis I (de novo)";"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis III (queuosine salvage)" lcl|NW_020311983.1_prot_XP_012267207.1_19475 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311353.1_prot_XP_025601840.1_5438 1 Reactome: R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins" lcl|NW_020311973.1_prot_XP_012258647.1_16567 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" lcl|NW_020311918.1_prot_XP_020711071.1_10416 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311375.1_prot_XP_012256594.1_6541 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311434.1_prot_XP_012252202.1_8738 3 Reactome: R-HSA-112311;Reactome: R-HSA-1483191;Reactome: R-HSA-422085 "Neurotransmitter clearance";"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin" lcl|NW_020311971.1_prot_XP_012260920.1_15832 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection" lcl|NW_020311933.1_prot_XP_012252876.1_10760 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311376.1_prot_XP_012251041.1_6568 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311925.1_prot_XP_012252606.1_10552 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311479.1_prot_XP_012253338.1_9458 1 Reactome: R-HSA-5689603 "UCH proteinases" lcl|NW_020311957.1_prot_XP_012262079.1_12728 12 MetaCyc: PWY-6683;KEGG: 00261+2.7.7.4;Reactome: R-HSA-2408550;MetaCyc: PWY-5278;KEGG: 00230+2.7.7.4;Reactome: R-HSA-174362;KEGG: 00450+2.7.7.4;KEGG: 00230+2.7.1.25;MetaCyc: PWY-6932;MetaCyc: PWY-5340;KEGG: 00920+2.7.7.4;KEGG: 00920+2.7.1.25 "Assimilatory sulfate reduction III";"Monobactam biosynthesis";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Sulfite oxidation III";"Purine metabolism";"Transport and synthesis of PAPS";"Selenocompound metabolism";"Purine metabolism";"Selenate reduction";"Sulfate activation for sulfonation";"Sulfur metabolism";"Sulfur metabolism" lcl|NW_020311984.1_prot_XP_020707559.1_19912 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" lcl|NW_020311992.1_prot_XP_012266454.1_21119 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311964.1_prot_XP_012261786.1_13889 56 Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-5668541;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610785;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-9010553;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-5610780;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-349425;Reactome: R-HSA-8939236;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-382556;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5689880;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-174113;Reactome: R-HSA-202424 "Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of RAS by GAPs";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"GLI3 is processed to GLI3R by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of expression of SLITs and ROBOs";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Degradation of GLI1 by the proteasome";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Autodegradation of the E3 ubiquitin ligase COP1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"ABC-family proteins mediated transport";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Ub-specific processing proteases";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling" lcl|NW_020311959.1_prot_XP_012262389.1_13075 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" lcl|NW_020311419.1_prot_XP_012254041.1_8092 13 MetaCyc: PWY-7184;KEGG: 00983+1.17.4.1;KEGG: 00230+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7220;Reactome: R-HSA-499943;MetaCyc: PWY-7222;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7210;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7226 "Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I" lcl|NW_020311313.1_prot_XP_012261655.1_3052 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311992.1_prot_XP_012266433.1_21220 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311294.1_prot_XP_020711022.1_865 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" lcl|NW_020311419.1_prot_XP_020707413.1_8060 15 Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-9603505;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167238;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-167200 "Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"NTRK3 as a dependence receptor";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat" lcl|NW_020311308.1_prot_XP_012264393.1_2219 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection" lcl|NW_020311368.1_prot_XP_020710820.1_6194 19 Reactome: R-HSA-3371571;Reactome: R-HSA-936837;Reactome: R-HSA-5673000;Reactome: R-HSA-5578775;Reactome: R-HSA-9617324;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-111932;Reactome: R-HSA-5576892;Reactome: R-HSA-9620244;Reactome: R-HSA-442982;Reactome: R-HSA-9022692;Reactome: R-HSA-6802955;Reactome: R-HSA-438066;Reactome: R-HSA-399719;Reactome: R-HSA-877300;Reactome: R-HSA-6802946;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001 "HSF1-dependent transactivation";"Ion transport by P-type ATPases";"RAF activation";"Ion homeostasis";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"CaMK IV-mediated phosphorylation of CREB";"Phase 0 - rapid depolarisation";"Long-term potentiation";"Ras activation upon Ca2+ influx through NMDA receptor";"Regulation of MECP2 expression and activity";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Unblocking of NMDA receptors, glutamate binding and activation";"Trafficking of AMPA receptors";"Interferon gamma signaling";"Signaling by moderate kinase activity BRAF mutants";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade" lcl|NW_020311994.1_prot_XP_012267457.1_21797 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311957.1_prot_XP_012263302.1_12863 5 Reactome: R-HSA-73772;Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-73762 "RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation" lcl|NW_020311403.1_prot_XP_012253790.1_7716 5 MetaCyc: PWY-6892;MetaCyc: PWY-6891;KEGG: 00900+2.2.1.7;MetaCyc: PWY-7560;KEGG: 00730+2.2.1.7 "Thiazole biosynthesis I (facultative anaerobic bacteria)";"Thiazole biosynthesis II (aerobic bacteria)";"Terpenoid backbone biosynthesis";"Methylerythritol phosphate pathway II";"Thiamine metabolism" lcl|NW_020311983.1_prot_XP_012267150.1_19457 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" lcl|NW_020311970.1_prot_XP_012256810.1_15729 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311391.1_prot_XP_025601965.1_7050 3 Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482 "Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events" lcl|NW_020311995.1_prot_XP_012257207.1_22013 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311323.1_prot_XP_020712046.1_3454 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" lcl|NW_020311988.1_prot_XP_020709728.1_20694 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" lcl|NW_020311297.1_prot_XP_012254107.1_1091 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311401.1_prot_XP_025601995.1_7593 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" lcl|NW_020311970.1_prot_XP_012260726.1_15654 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311991.1_prot_XP_012269766.1_20864 5 Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-1257604;Reactome: R-HSA-389357;Reactome: R-HSA-6804757 "Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling";"Regulation of TP53 Degradation" lcl|NW_020311978.1_prot_XP_012257704.1_18135 4 KEGG: 00250+6.3.4.4;Reactome: R-HSA-73817;MetaCyc: PWY-7219;KEGG: 00230+6.3.4.4 "Alanine, aspartate and glutamate metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311472.1_prot_XP_012269228.1_9320 18 Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-167152;Reactome: R-HSA-167158;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167238;Reactome: R-HSA-167242;Reactome: R-HSA-6807505 "RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the HIV-1 Early Elongation Complex";"Formation of the Early Elongation Complex";"mRNA Capping";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA polymerase II transcribes snRNA genes" lcl|NW_020311469.1_prot_XP_012266618.1_9298 1 Reactome: R-HSA-2028269 "Signaling by Hippo" lcl|NW_020311332.1_prot_XP_012256253.1_4151 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311993.1_prot_XP_020710403.1_21400 2 Reactome: R-HSA-8869496;Reactome: R-HSA-6790901 "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation";"rRNA modification in the nucleus and cytosol" lcl|NW_020311958.1_prot_XP_012254967.1_12923 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311983.1_prot_XP_012267149.1_19456 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" lcl|NW_020311984.1_prot_XP_020707597.1_19845 4 Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-3769402 "Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex" lcl|NW_020311364.1_prot_XP_020708941.1_5907 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311918.1_prot_XP_012265096.1_10411 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311988.1_prot_XP_012261123.1_20727 2 KEGG: 00983+3.6.1.23;KEGG: 00240+3.6.1.23 "Drug metabolism - other enzymes";"Pyrimidine metabolism" lcl|NW_020311940.1_prot_XP_012265585.1_11219 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311432.1_prot_XP_012268575.1_8340 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311965.1_prot_XP_020709441.1_14048 32 Reactome: R-HSA-167162;Reactome: R-HSA-167238;Reactome: R-HSA-73776;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-72165;Reactome: R-HSA-77075;Reactome: R-HSA-75953;Reactome: R-HSA-8851708;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-72203;Reactome: R-HSA-167152;Reactome: R-HSA-167161;Reactome: R-HSA-75955;Reactome: R-HSA-6803529;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-73779;Reactome: R-HSA-72086;Reactome: R-HSA-6807505;Reactome: R-HSA-167242;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-168325;Reactome: R-HSA-9018519;Reactome: R-HSA-76042;Reactome: R-HSA-113418;Reactome: R-HSA-72163 "RNA Polymerase II HIV Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Promoter Escape";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"mRNA Splicing - Minor Pathway";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV Transcription Initiation";"RNA Polymerase II Transcription Elongation";"FGFR2 alternative splicing";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Capping";"RNA polymerase II transcribes snRNA genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Viral Messenger RNA Synthesis";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of the Early Elongation Complex";"mRNA Splicing - Major Pathway" lcl|NW_020311948.1_prot_XP_012253488.1_12031 3 Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" lcl|NW_020311945.1_prot_XP_020706187.1_11806 7 KEGG: 00380+2.3.1.61;KEGG: 00310+2.3.1.61;Reactome: R-HSA-389661;MetaCyc: PWY-5084;Reactome: R-HSA-71403;KEGG: 00020+2.3.1.61;Reactome: R-HSA-71064 "Tryptophan metabolism";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Lysine catabolism" lcl|NW_020311940.1_prot_XP_012265519.1_11168 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" lcl|NW_020311503.1_prot_XP_012255233.1_9609 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311976.1_prot_XP_012257728.1_17373 1 Reactome: R-HSA-420029 "Tight junction interactions" lcl|NW_020311334.1_prot_XP_012265912.1_4375 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311957.1_prot_XP_012262072.1_12752 4 KEGG: 00230+6.3.5.2;Reactome: R-HSA-73817;MetaCyc: PWY-7221;KEGG: 00983+6.3.5.2 "Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes" lcl|NW_020311992.1_prot_XP_012266330.1_21212 2 Reactome: R-HSA-6798695;Reactome: R-HSA-983168 "Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311994.1_prot_XP_012264834.1_21809 8 Reactome: R-HSA-111464;Reactome: R-HSA-111458;Reactome: R-HSA-8953750;Reactome: R-HSA-6798695;Reactome: R-HSA-111459;Reactome: R-HSA-9627069;Reactome: R-HSA-6803207;Reactome: R-HSA-111463 "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Formation of apoptosome";"Transcriptional Regulation by E2F6";"Neutrophil degranulation";"Activation of caspases through apoptosome-mediated cleavage";"Regulation of the apoptosome activity";"TP53 Regulates Transcription of Caspase Activators and Caspases";"SMAC (DIABLO) binds to IAPs" lcl|NW_020311424.1_prot_XP_020707855.1_8178 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311965.1_prot_XP_012259976.1_14219 5 MetaCyc: PWY-7919;Reactome: R-HSA-532668;Reactome: R-HSA-4793954;KEGG: 00510+3.2.1.106;MetaCyc: PWY-7918 "Protein N-glycosylation processing phase (plants and animals)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-Glycan biosynthesis";"Protein N-glycosylation processing phase (yeast)" lcl|NW_020311980.1_prot_XP_012253813.1_18725 4 Reactome: R-HSA-5205685;Reactome: R-HSA-8934903;Reactome: R-HSA-936440;Reactome: R-HSA-1632852 "Pink/Parkin Mediated Mitophagy";"Receptor Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling";"Macroautophagy" lcl|NW_020311472.1_prot_XP_012269224.1_9326 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311943.1_prot_XP_012255251.1_11681 1 Reactome: R-HSA-6803204 "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" lcl|NW_020311982.1_prot_XP_020708774.1_19192 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" lcl|NW_020311333.1_prot_XP_012255949.1_4257 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311973.1_prot_XP_012258780.1_16466 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311439.1_prot_XP_020710759.1_8844 2 Reactome: R-HSA-400253;Reactome: R-HSA-2151201 "Circadian Clock";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311312.1_prot_XP_012266796.1_2610 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311974.1_prot_XP_020709387.1_16921 2 Reactome: R-HSA-416993;Reactome: R-HSA-202733 "Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall" lcl|NW_020311332.1_prot_XP_012256842.1_4198 5 Reactome: R-HSA-75035;Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311917.1_prot_XP_012250980.1_10245 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311325.1_prot_XP_020706325.1_3673 7 Reactome: R-HSA-381042;Reactome: R-HSA-983170;Reactome: R-HSA-381033;Reactome: R-HSA-114608;Reactome: R-HSA-381070;Reactome: R-HSA-3371453;Reactome: R-HSA-381183 "PERK regulates gene expression";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"ATF6 (ATF6-alpha) activates chaperones";"Platelet degranulation";"IRE1alpha activates chaperones";"Regulation of HSF1-mediated heat shock response";"ATF6 (ATF6-alpha) activates chaperone genes" lcl|NW_020311973.1_prot_XP_012258639.1_16474 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" lcl|NW_020311918.1_prot_XP_012265012.1_10358 13 Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-156902 "Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation" lcl|NW_020311482.1_prot_XP_012269653.1_9477 1 Reactome: R-HSA-114608 "Platelet degranulation" lcl|NW_020311979.1_prot_XP_012259371.1_18495 2 Reactome: R-HSA-5658442;Reactome: R-HSA-6802953 "Regulation of RAS by GAPs";"RAS signaling downstream of NF1 loss-of-function variants" lcl|NW_020311298.1_prot_XP_012250514.1_1138 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311992.1_prot_XP_012266280.1_21090 17 Reactome: R-HSA-6796648;KEGG: 04150+2.7.11.1;Reactome: R-HSA-1433557;Reactome: R-HSA-6804756;KEGG: 04714+2.7.11.1;Reactome: R-HSA-8953750;Reactome: R-HSA-5693607;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693616;Reactome: R-HSA-176187;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69473;Reactome: R-HSA-75035;KEGG: 05165+2.7.11.1;Reactome: R-HSA-69601;KEGG: 04151+2.7.11.1 "TP53 Regulates Transcription of DNA Repair Genes";"mTOR signaling pathway";"Signaling by SCF-KIT";"Regulation of TP53 Activity through Phosphorylation";"Thermogenesis";"Transcriptional Regulation by E2F6";"Processing of DNA double-strand break ends";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"Relaxin signaling pathway";"G2/M DNA damage checkpoint";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Human papillomavirus infection";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"PI3K-Akt signaling pathway" lcl|NW_020311978.1_prot_XP_020708571.1_18061 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311995.1_prot_XP_012257087.1_22102 5 Reactome: R-HSA-380972;Reactome: R-HSA-165181;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-8854214 "Energy dependent regulation of mTOR by LKB1-AMPK";"Inhibition of TSC complex formation by PKB";"TP53 Regulates Metabolic Genes";"Macroautophagy";"TBC/RABGAPs" lcl|NW_020311966.1_prot_XP_012256412.1_15160 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" lcl|NW_020311309.1_prot_XP_012259107.1_2306 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" lcl|NW_020311983.1_prot_XP_020707871.1_19810 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311984.1_prot_XP_020710933.1_19819 8 Reactome: R-HSA-70268;MetaCyc: PWY-6901;KEGG: 00620+1.1.1.27;MetaCyc: PWY-8086;KEGG: 00270+1.1.1.27;KEGG: 00010+1.1.1.27;KEGG: 00640+1.1.1.27;MetaCyc: PWY-5481 "Pyruvate metabolism";"Superpathway of glucose and xylose degradation";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Cysteine and methionine metabolism";"Glycolysis / Gluconeogenesis";"Propanoate metabolism";"Pyruvate fermentation to (S)-lactate" lcl|NW_020311887.1_prot_XP_012267024.1_10126 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311419.1_prot_XP_012254068.2_8088 3 Reactome: R-HSA-76071;Reactome: R-HSA-6807505;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311980.1_prot_XP_012255714.1_18924 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" lcl|NW_020311299.1_prot_XP_012267798.1_1396 6 Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-6798695;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-9639288 "Ion channel transport";"ROS and RNS production in phagocytes";"Neutrophil degranulation";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Amino acids regulate mTORC1" lcl|NW_020311436.1_prot_XP_025602104.1_8771 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311418.1_prot_XP_012261029.1_8037 3 Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621 "Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism" lcl|NW_020311971.1_prot_XP_012260921.1_15834 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311312.1_prot_XP_012266812.1_2661 7 MetaCyc: PWY-5265;MetaCyc: PWY-6471;Reactome: R-HSA-446193;KEGG: 00510+2.7.8.15;Reactome: R-HSA-4549356;MetaCyc: PWY-6470;KEGG: 00550+2.7.8.13 "Peptidoglycan biosynthesis II (staphylococci)";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2";"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis" lcl|NW_020311304.1_prot_XP_012261395.1_1893 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311984.1_prot_XP_012254616.1_19901 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" lcl|NW_020311986.1_prot_XP_012258839.1_20353 19 KEGG: 00020+1.1.1.37;KEGG: 00630+1.1.1.37;MetaCyc: PWY-6969;KEGG: 00680+1.1.1.37;KEGG: 00710+1.1.1.37;KEGG: 00720+1.1.1.37;MetaCyc: PWY-561;MetaCyc: PWY-5392;MetaCyc: PWY-5690;MetaCyc: PWY-6728;MetaCyc: PWY-7383;KEGG: 00620+1.1.1.37;Reactome: R-HSA-70263;Reactome: R-HSA-71403;MetaCyc: PWY-8086;MetaCyc: PWY-5913;MetaCyc: PWY-1622;KEGG: 00270+1.1.1.37;MetaCyc: PWY-7115 "Citrate cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methane metabolism";"Carbon fixation in photosynthetic organisms";"Carbon fixation pathways in prokaryotes";"Superpathway of glyoxylate cycle and fatty acid degradation";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Anaerobic energy metabolism (invertebrates, cytosol)";"Pyruvate metabolism";"Gluconeogenesis";"Citric acid cycle (TCA cycle)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Partial TCA cycle (obligate autotrophs)";"Formaldehyde assimilation I (serine pathway)";"Cysteine and methionine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type" lcl|NW_020311943.1_prot_XP_020707700.1_11653 5 MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-6902;Reactome: R-HSA-189085 "Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Digestion of dietary carbohydrate" lcl|NW_020311302.1_prot_XP_012264546.2_1671 1 Reactome: R-HSA-5635838 "Activation of SMO" lcl|NW_020311970.1_prot_XP_012269079.1_15619 9 Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-6807505 "RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HIV Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA polymerase II transcribes snRNA genes" lcl|NW_020311298.1_prot_XP_012250540.1_1201 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311309.1_prot_XP_012259135.1_2374 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311975.1_prot_XP_012266009.1_17172 2 Reactome: R-HSA-196780;Reactome: R-HSA-3371599 "Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency" lcl|NW_020311992.1_prot_XP_012266295.1_21136 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" lcl|NW_020311967.1_prot_XP_012254334.1_15338 4 Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-975957 "Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311298.1_prot_XP_012269890.1_1329 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311300.1_prot_XP_012253241.1_1494 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311381.1_prot_XP_012252347.1_6829 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311391.1_prot_XP_025601967.1_7052 3 Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482 "Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events" lcl|NW_020311365.1_prot_XP_020712497.1_6022 2 Reactome: R-HSA-5205685;Reactome: R-HSA-983231 "Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production" lcl|NW_020311965.1_prot_XP_020709429.1_14137 1 Reactome: R-HSA-5693568 "Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311477.1_prot_XP_020710086.1_9428 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311304.1_prot_XP_012261428.1_1890 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311393.1_prot_XP_012265751.1_7155 7 KEGG: 00240+3.5.2.3;MetaCyc: PWY-7791;MetaCyc: PWY-7790;MetaCyc: PWY-5686;KEGG: 00230+3.5.2.5;MetaCyc: PWY-5698;MetaCyc: PWY-5697 "Pyrimidine metabolism";"UMP biosynthesis III";"UMP biosynthesis II";"UMP biosynthesis I";"Purine metabolism";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Allantoin degradation to ureidoglycolate I (urea producing)" lcl|NW_020311312.1_prot_XP_012266915.1_2592 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" lcl|NW_020311401.1_prot_XP_020707670.1_7683 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" lcl|NW_020311941.1_prot_XP_012253216.1_11407 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311958.1_prot_XP_012255513.1_12957 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" lcl|NW_020311346.1_prot_XP_012262934.1_4940 2 KEGG: 00970+6.1.1.3;Reactome: R-HSA-114608 "Aminoacyl-tRNA biosynthesis";"Platelet degranulation" lcl|NW_020311966.1_prot_XP_012256916.1_14715 6 Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex" lcl|NW_020311915.1_prot_XP_012262417.1_10181 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311977.1_prot_XP_012263780.1_17707 6 MetaCyc: PWY-6987;MetaCyc: PWY-7382;KEGG: 00785+2.3.1.181;KEGG: 00780+6.3.4.15;Reactome: R-HSA-196780;Reactome: R-HSA-3371599 "Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism";"Biotin metabolism";"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency" lcl|NW_020311374.1_prot_XP_012264655.1_6529 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311299.1_prot_XP_012263154.1_1468 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311955.1_prot_XP_012265409.1_12389 10 MetaCyc: PWY-7328;MetaCyc: PWY-6397;MetaCyc: PWY-3821;Reactome: R-HSA-70370;MetaCyc: PWY-6527;MetaCyc: PWY-6317;Reactome: R-HSA-5609977;KEGG: 00520+5.1.3.2;MetaCyc: PWY-7344;KEGG: 00052+5.1.3.2 "Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose detoxification";"Galactose catabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Amino sugar and nucleotide sugar metabolism";"UDP-alpha-D-galactose biosynthesis";"Galactose metabolism" lcl|NW_020311995.1_prot_XP_012257188.1_22062 1 KEGG: 00970+6.1.1.9 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311985.1_prot_XP_012265212.1_20259 6 Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733 "Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis" lcl|NW_020311311.1_prot_XP_012250843.1_2517 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311977.1_prot_XP_012253923.1_17501 27 Reactome: R-HSA-4570464;Reactome: R-HSA-3108214;Reactome: R-HSA-3371453;Reactome: R-HSA-5619107;Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-159227;Reactome: R-HSA-3301854;Reactome: R-HSA-180746;Reactome: R-HSA-3232142;Reactome: R-HSA-4615885;Reactome: R-HSA-4085377;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-180910;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-168276;Reactome: R-HSA-5578749 "SUMOylation of RNA binding proteins";"SUMOylation of DNA damage response and repair proteins";"Regulation of HSF1-mediated heat shock response";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA replication proteins";"SUMOylation of SUMOylation proteins";"HCMV Early Events";"ISG15 antiviral mechanism";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"Vpr-mediated nuclear import of PICs";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs" lcl|NW_020311995.1_prot_XP_012257101.1_22068 7 MetaCyc: PWY-7214;MetaCyc: PWY-6824;MetaCyc: PWY-7445;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461;MetaCyc: PWY-5466;MetaCyc: PWY-5469 "Baicalein degradation (hydrogen peroxide detoxification)";"Justicidin B biosynthesis";"Luteolin triglucuronide degradation";"Phenylpropanoid biosynthesis";"Betanidin degradation";"Matairesinol biosynthesis";"Sesamin biosynthesis" lcl|NW_020311349.1_prot_XP_012251228.1_5285 40 Reactome: R-HSA-72086;Reactome: R-HSA-75955;Reactome: R-HSA-6781827;Reactome: R-HSA-6803529;Reactome: R-HSA-5601884;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-73779;Reactome: R-HSA-203927;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-77075;Reactome: R-HSA-8851708;Reactome: R-HSA-75953;Reactome: R-HSA-72165;Reactome: R-HSA-72203;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-5617472;Reactome: R-HSA-167243;Reactome: R-HSA-167162;Reactome: R-HSA-167238;Reactome: R-HSA-5578749;Reactome: R-HSA-73776;Reactome: R-HSA-76042;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-112382;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-6796648;Reactome: R-HSA-6807505;Reactome: R-HSA-167242 "mRNA Capping";"RNA Polymerase II Transcription Elongation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"FGFR2 alternative splicing";"PIWI-interacting RNA (piRNA) biogenesis";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"MicroRNA (miRNA) biogenesis";"HIV Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Pol II CTD phosphorylation and interaction with CE";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Initiation";"mRNA Splicing - Minor Pathway";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II HIV Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"Transcriptional regulation by small RNAs";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"Formation of RNA Pol II elongation complex";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"TP53 Regulates Transcription of DNA Repair Genes";"RNA polymerase II transcribes snRNA genes";"Abortive elongation of HIV-1 transcript in the absence of Tat" lcl|NW_020311966.1_prot_XP_012256630.1_14969 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311940.1_prot_XP_020711254.1_11316 14 MetaCyc: PWY-6453;MetaCyc: PWY-7417;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7411;MetaCyc: PWY-5981;MetaCyc: PWY-7589 "Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)" lcl|NW_020311975.1_prot_XP_012252227.1_17061 1 Reactome: R-HSA-196741 "Cobalamin (Cbl, vitamin B12) transport and metabolism" lcl|NW_020311977.1_prot_XP_012263680.1_17804 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311401.1_prot_XP_012254683.1_7472 2 KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710 "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311513.1_prot_XP_012266051.1_9778 2 Reactome: R-HSA-430039;Reactome: R-HSA-72163 "mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway" lcl|NW_020311413.1_prot_XP_012254403.1_7907 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311985.1_prot_XP_012265225.1_20229 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311313.1_prot_XP_012261813.1_2813 22 MetaCyc: PWY-5080;MetaCyc: PWY-7049;MetaCyc: PWY-7619;MetaCyc: PWY-7728;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7727;MetaCyc: PWY-7724;MetaCyc: PWY-7726;Reactome: R-HSA-75876;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-6433;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-6958;MetaCyc: PWY-5353;MetaCyc: PWY-7601;MetaCyc: PWY-7606;MetaCyc: PWY-7053;MetaCyc: PWY-7035;MetaCyc: PWY-7592 "Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Juniperonate biosynthesis";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Fatty acid elongation";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Synthesis of very long-chain fatty acyl-CoAs";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis III (6-desaturase, mammals)" lcl|NW_020311375.1_prot_XP_012256469.2_6555 1 Reactome: R-HSA-1296061 "HCN channels" lcl|NW_020311917.1_prot_XP_012250950.1_10229 7 KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311988.1_prot_XP_020709724.1_20698 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157 "MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions" lcl|NW_020311292.1_prot_XP_020706835.1_585 1 KEGG: 00970+6.1.1.16 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311332.1_prot_XP_012256967.1_4162 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311977.1_prot_XP_012263956.1_18031 14 Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7602;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-5972 "Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Fatty acid elongation";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)" lcl|NW_020311324.1_prot_XP_012269365.1_3569 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311975.1_prot_XP_012266213.1_17199 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311992.1_prot_XP_012266459.1_21122 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311353.1_prot_XP_012255932.1_5429 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311974.1_prot_XP_012260234.1_16896 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311401.1_prot_XP_020707759.1_7580 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311292.1_prot_XP_012252417.1_633 1 Reactome: R-HSA-426486 "Small interfering RNA (siRNA) biogenesis" lcl|NW_020311314.1_prot_XP_025603064.1_3067 6 MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84 "Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis" lcl|NW_020311940.1_prot_XP_012265580.1_11216 7 MetaCyc: PWY-7238;MetaCyc: PWY-6724;Reactome: R-HSA-6798695;Reactome: R-HSA-70221;MetaCyc: PWY-5941;MetaCyc: PWY-6737;KEGG: 00500+2.4.1.25 "Sucrose biosynthesis II";"Starch degradation II";"Neutrophil degranulation";"Glycogen breakdown (glycogenolysis)";"Glycogen degradation II";"Starch degradation V";"Starch and sucrose metabolism" lcl|NW_020311349.1_prot_XP_012251164.1_5332 3 Reactome: R-HSA-3299685;KEGG: 00230+3.6.1.17;KEGG: 00240+3.6.1.17 "Detoxification of Reactive Oxygen Species";"Purine metabolism";"Pyrimidine metabolism" lcl|NW_020311320.1_prot_XP_020709103.1_3350 2 KEGG: 04070+2.7.11.13;Reactome: R-HSA-1660661 "Phosphatidylinositol signaling system";"Sphingolipid de novo biosynthesis" lcl|NW_020311959.1_prot_XP_012262379.1_13117 5 MetaCyc: PWY-5667;KEGG: 00564+2.7.7.41;MetaCyc: PWY-5981;KEGG: 04070+2.7.7.41;MetaCyc: PWY-7817 "CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)" lcl|NW_020311432.1_prot_XP_012268730.1_8416 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" lcl|NW_020311291.1_prot_XP_020709165.1_460 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" lcl|NW_020311926.1_prot_XP_012250728.1_10612 8 Reactome: R-HSA-4608870;Reactome: R-HSA-4641263;Reactome: R-HSA-373080;Reactome: R-HSA-8856828;Reactome: R-HSA-5340588;Reactome: R-HSA-8856825;Reactome: R-HSA-5099900;Reactome: R-HSA-4086398 "Asymmetric localization of PCP proteins";"Regulation of FZD by ubiquitination";"Class B/2 (Secretin family receptors)";"Clathrin-mediated endocytosis";"RNF mutants show enhanced WNT signaling and proliferation";"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD4";"Ca2+ pathway" lcl|NW_020311424.1_prot_XP_012255442.1_8185 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311979.1_prot_XP_012259721.1_18540 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311304.1_prot_XP_012261163.1_1755 5 Reactome: R-HSA-8856828;Reactome: R-HSA-6807004;Reactome: R-HSA-8875360;Reactome: R-HSA-182971;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Negative regulation of MET activity";"InlB-mediated entry of Listeria monocytogenes into host cell";"EGFR downregulation";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311966.1_prot_XP_012257002.1_15088 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311971.1_prot_XP_025602668.1_15837 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311946.1_prot_XP_012268639.1_11916 2 Reactome: R-HSA-975956;Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311359.1_prot_XP_020706699.1_5702 1 Reactome: R-HSA-419037 "NCAM1 interactions" lcl|NW_020311477.1_prot_XP_020710084.1_9426 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311434.1_prot_XP_020706763.1_8736 3 Reactome: R-HSA-112311;Reactome: R-HSA-1483191;Reactome: R-HSA-422085 "Neurotransmitter clearance";"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin" lcl|NW_020311945.1_prot_XP_012269646.1_11805 7 KEGG: 00380+2.3.1.61;KEGG: 00310+2.3.1.61;Reactome: R-HSA-389661;MetaCyc: PWY-5084;Reactome: R-HSA-71403;KEGG: 00020+2.3.1.61;Reactome: R-HSA-71064 "Tryptophan metabolism";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Lysine catabolism" lcl|NW_020311985.1_prot_XP_020707352.1_20295 9 Reactome: R-HSA-1475029;MetaCyc: PWY-5744;KEGG: 00910+4.2.1.1;MetaCyc: PWY-241;MetaCyc: PWY-7117;MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142 "Reversible hydration of carbon dioxide";"Glyoxylate assimilation";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)" lcl|NW_020311310.1_prot_XP_012255773.1_2424 13 Reactome: R-HSA-8856828;Reactome: R-HSA-177504;Reactome: R-HSA-8866427;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-5140745;Reactome: R-HSA-182218;Reactome: R-HSA-8964038;Reactome: R-HSA-167590;Reactome: R-HSA-5099900;Reactome: R-HSA-437239;Reactome: R-HSA-2132295;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Retrograde neurotrophin signalling";"VLDLR internalisation and degradation";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Nef Mediated CD8 Down-regulation";"LDL clearance";"Nef Mediated CD4 Down-regulation";"WNT5A-dependent internalization of FZD4";"Recycling pathway of L1";"MHC class II antigen presentation";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311338.1_prot_XP_020710338.1_4587 2 Reactome: R-HSA-2514853;Reactome: R-HSA-2299718 "Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes" lcl|NW_020311325.1_prot_XP_020706315.1_3678 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" lcl|NW_020311294.1_prot_XP_012264955.1_912 4 Reactome: R-HSA-964975;KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282;MetaCyc: PWY-7204 "Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Pyridoxal 5'-phosphate salvage II (plants)" lcl|NW_020311291.1_prot_XP_012259526.1_470 19 Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-8876725;Reactome: R-HSA-3214858;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-6790901;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9010553 "Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Protein methylation";"RMTs methylate histone arginines";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"rRNA modification in the nucleus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311350.1_prot_XP_012250765.1_5347 6 Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220 "EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins" lcl|NW_020311499.1_prot_XP_012269213.1_9553 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311983.1_prot_XP_020711766.1_19498 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" lcl|NW_020311995.1_prot_XP_012256858.1_22021 8 Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-174430;Reactome: R-HSA-113501;Reactome: R-HSA-69183;Reactome: R-HSA-69166;Reactome: R-HSA-68952;Reactome: R-HSA-69091 "Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand synthesis initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate";"DNA replication initiation";"Polymerase switching" lcl|NW_020311408.1_prot_XP_012262108.1_7805 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311971.1_prot_XP_020710531.1_16081 12 Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-6807878 "Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"HCMV Early Events";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"COPI-mediated anterograde transport" lcl|NW_020311459.1_prot_XP_012260499.1_9170 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311344.1_prot_XP_012251148.1_4876 7 Reactome: R-HSA-5362798;Reactome: R-HSA-373080;Reactome: R-HSA-5632681;Reactome: R-HSA-5635838;Reactome: R-HSA-5358346;Reactome: R-HSA-5632684;Reactome: R-HSA-5658034 "Release of Hh-Np from the secreting cell";"Class B/2 (Secretin family receptors)";"Ligand-receptor interactions";"Activation of SMO";"Hedgehog ligand biogenesis";"Hedgehog 'on' state";"HHAT G278V abrogates palmitoylation of Hh-Np" lcl|NW_020311982.1_prot_XP_020708815.1_19304 4 Reactome: R-HSA-77075;Reactome: R-HSA-167160;MetaCyc: PWY-7375;Reactome: R-HSA-72086 "RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Mrna capping I";"mRNA Capping" lcl|NW_020311962.1_prot_XP_012251966.1_13768 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311994.1_prot_XP_020711904.1_21740 5 MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083 "NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation" lcl|NW_020311985.1_prot_XP_020711134.1_20221 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311391.1_prot_XP_012256738.1_7024 4 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311308.1_prot_XP_020710829.1_2196 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311331.1_prot_XP_012264333.1_4060 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311292.1_prot_XP_012262843.1_697 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311918.1_prot_XP_012265010.1_10435 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311980.1_prot_XP_020709779.1_18787 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311967.1_prot_XP_025602604.1_15250 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311948.1_prot_XP_012253484.1_12030 7 MetaCyc: PWY-6121;KEGG: 00230+2.4.2.14;MetaCyc: PWY-6122;MetaCyc: PWY-7282;MetaCyc: PWY-6277;Reactome: R-HSA-73817;KEGG: 00250+2.4.2.14 "5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis II";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311966.1_prot_XP_020708191.1_15043 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311984.1_prot_XP_012254447.1_19864 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311984.1_prot_XP_012267658.1_20167 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311974.1_prot_XP_012259804.1_16736 3 MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2 "Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism" lcl|NW_020311978.1_prot_XP_020708685.1_18319 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311973.1_prot_XP_012258542.1_16498 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" lcl|NW_020311331.1_prot_XP_012264322.1_4087 4 Reactome: R-HSA-5673001;Reactome: R-HSA-445095;Reactome: R-HSA-375165;Reactome: R-HSA-6807878 "RAF/MAP kinase cascade";"Interaction between L1 and Ankyrins";"NCAM signaling for neurite out-growth";"COPI-mediated anterograde transport" lcl|NW_020311970.1_prot_XP_012267613.1_15780 1 Reactome: R-HSA-72165 "mRNA Splicing - Minor Pathway" lcl|NW_020311994.1_prot_XP_025603016.1_21786 14 Reactome: R-HSA-426486;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-203927;Reactome: R-HSA-9029569;Reactome: R-HSA-8943723;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-8948700;Reactome: R-HSA-8934593 "Small interfering RNA (siRNA) biogenesis";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"MicroRNA (miRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of PTEN mRNA translation";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of RUNX1 Expression and Activity" lcl|NW_020311313.1_prot_XP_012261693.1_3034 1 Reactome: R-HSA-419771 "Opsins" lcl|NW_020311994.1_prot_XP_012267543.1_21691 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" lcl|NW_020311994.1_prot_XP_012267462.1_21788 2 Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7 "Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311340.1_prot_XP_020706183.1_4685 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311312.1_prot_XP_012266877.1_2673 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311940.1_prot_XP_020711232.1_11183 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311982.1_prot_XP_012258260.1_19212 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311917.1_prot_XP_012250979.1_10244 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311349.1_prot_XP_012251120.1_5265 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311958.1_prot_XP_025602450.1_12915 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311329.1_prot_XP_025601733.1_3946 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311980.1_prot_XP_020707963.1_18895 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" lcl|NW_020311971.1_prot_XP_012263518.1_16100 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311286.1_prot_XP_020708333.1_50 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311966.1_prot_XP_012252943.1_14416 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311364.1_prot_XP_012258859.1_5923 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins" lcl|NW_020311976.1_prot_XP_012257664.1_17389 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311432.1_prot_XP_020712263.1_8508 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" lcl|NW_020311401.1_prot_XP_012255300.1_7438 8 KEGG: 04714+2.7.11.1;Reactome: R-HSA-9633012;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway" lcl|NW_020311984.1_prot_XP_012254605.1_19914 11 Reactome: R-HSA-5693616;Reactome: R-HSA-5358606;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938;Reactome: R-HSA-5358565;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5693579 "Presynaptic phase of homologous DNA pairing and strand exchange";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Homologous DNA Pairing and Strand Exchange" lcl|NW_020311962.1_prot_XP_012252041.1_13565 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311966.1_prot_XP_020708372.1_15154 13 Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689 "Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits" lcl|NW_020311955.1_prot_XP_020711171.1_12506 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311968.1_prot_XP_012253085.1_15435 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" lcl|NW_020311978.1_prot_XP_012257873.1_18375 1 Reactome: R-HSA-203641 "NOSTRIN mediated eNOS trafficking" lcl|NW_020311981.1_prot_XP_012257459.1_19075 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311346.1_prot_XP_012262954.1_4955 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311304.1_prot_XP_020709583.1_1914 10 Reactome: R-HSA-202424;Reactome: R-HSA-2565942;Reactome: R-HSA-5607764;Reactome: R-HSA-2871837;Reactome: R-HSA-5607761;Reactome: R-HSA-1169091;Reactome: R-HSA-5684264;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-5676590 "Downstream TCR signaling";"Regulation of PLK1 Activity at G2/M Transition";"CLEC7A (Dectin-1) signaling";"FCERI mediated NF-kB activation";"Dectin-1 mediated noncanonical NF-kB signaling";"Activation of NF-kappaB in B cells";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"NIK-->noncanonical NF-kB signaling" lcl|NW_020311306.1_prot_XP_020710746.1_2099 4 MetaCyc: PWY-6823;KEGG: 00790+4.1.99.22;KEGG: 00790+4.6.1.17;Reactome: R-HSA-947581 "Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis" lcl|NW_020311966.1_prot_XP_012256401.1_14941 2 Reactome: R-HSA-8949664;Reactome: R-HSA-8949215 "Processing of SMDT1";"Mitochondrial calcium ion transport" lcl|NW_020311299.1_prot_XP_012263177.1_1474 2 KEGG: 00970+6.1.1.21;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" lcl|NW_020311372.1_prot_XP_012268404.1_6332 2 Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2 "Signaling by SCF-KIT";"T cell receptor signaling pathway" lcl|NW_020311966.1_prot_XP_012253698.1_14513 3 Reactome: R-HSA-400206;Reactome: R-HSA-427413;Reactome: R-HSA-8936459 "Regulation of lipid metabolism by PPARalpha";"NoRC negatively regulates rRNA expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311294.1_prot_XP_020711027.1_864 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311967.1_prot_XP_020707517.1_15294 1 Reactome: R-HSA-606279 "Deposition of new CENPA-containing nucleosomes at the centromere" lcl|NW_020311977.1_prot_XP_020710545.1_17771 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311436.1_prot_XP_012258374.1_8766 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311401.1_prot_XP_012255061.1_7633 16 Reactome: R-HSA-8936459;Reactome: R-HSA-2559585;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-8934593;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-9029569;Reactome: R-HSA-9018519;Reactome: R-HSA-9022692;Reactome: R-HSA-8986944;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Oncogene Induced Senescence";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"Regulation of RUNX1 Expression and Activity";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Estrogen-dependent gene expression";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by MECP2";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence" lcl|NW_020311974.1_prot_XP_012260213.1_16678 3 Reactome: R-HSA-2980766;Reactome: R-HSA-4419969;Reactome: R-HSA-2995383 "Nuclear Envelope Breakdown";"Depolymerisation of the Nuclear Lamina";"Initiation of Nuclear Envelope Reformation" lcl|NW_020311345.1_prot_XP_012254294.1_4911 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" lcl|NW_020311990.1_prot_XP_012266682.1_20833 7 Reactome: R-HSA-9648025;Reactome: R-HSA-606279;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220 "EML4 and NUDC in mitotic spindle formation";"Deposition of new CENPA-containing nucleosomes at the centromere";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins" lcl|NW_020311317.1_prot_XP_012250725.1_3258 10 Reactome: R-HSA-201688;Reactome: R-HSA-445144;Reactome: R-HSA-2514853;Reactome: R-HSA-8948751;Reactome: R-HSA-8934903;Reactome: R-HSA-1483191;Reactome: R-HSA-6798695;Reactome: R-HSA-6804756;Reactome: R-HSA-8939243;Reactome: R-HSA-6814122 "WNT mediated activation of DVL";"Signal transduction by L1";"Condensation of Prometaphase Chromosomes";"Regulation of PTEN stability and activity";"Receptor Mediated Mitophagy";"Synthesis of PC";"Neutrophil degranulation";"Regulation of TP53 Activity through Phosphorylation";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" lcl|NW_020311382.1_prot_XP_020712034.1_6849 2 Reactome: R-HSA-8949215;Reactome: R-HSA-5689880 "Mitochondrial calcium ion transport";"Ub-specific processing proteases" lcl|NW_020311983.1_prot_XP_012255652.1_19723 12 Reactome: R-HSA-381038;Reactome: R-HSA-5620912;Reactome: R-HSA-6807878;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-2132295;Reactome: R-HSA-2565942;Reactome: R-HSA-3371497;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-6811436;Reactome: R-HSA-380270 "XBP1(S) activates chaperone genes";"Anchoring of the basal body to the plasma membrane";"COPI-mediated anterograde transport";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"MHC class II antigen presentation";"Regulation of PLK1 Activity at G2/M Transition";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311973.1_prot_XP_012258669.1_16588 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311977.1_prot_XP_012264027.1_17964 11 Reactome: R-HSA-3214847;Reactome: R-HSA-5689880;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-73779 "HATs acetylate histones";"Ub-specific processing proteases";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311312.1_prot_XP_012266792.1_2607 5 Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-1222556 "Transferrin endocytosis and recycling";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Ion channel transport";"ROS and RNS production in phagocytes" lcl|NW_020311419.1_prot_XP_012254053.1_8085 5 KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7979 "Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation III (mammals, core M3)" lcl|NW_020311401.1_prot_XP_012255058.1_7639 16 Reactome: R-HSA-9029569;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-8986944;Reactome: R-HSA-5687128;Reactome: R-HSA-8853884;Reactome: R-HSA-2559585;Reactome: R-HSA-8936459;Reactome: R-HSA-8934593;Reactome: R-HSA-8943723 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Transcriptional Regulation by MECP2";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by VENTX";"Oncogene Induced Senescence";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX1 Expression and Activity";"Regulation of PTEN mRNA translation" lcl|NW_020311962.1_prot_XP_012251963.1_13769 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311978.1_prot_XP_012257907.1_18295 12 Reactome: R-HSA-210744;Reactome: R-HSA-350054;Reactome: R-HSA-8941856;Reactome: R-HSA-3214847;Reactome: R-HSA-9013508;Reactome: R-HSA-1912408;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Notch-HLH transcription pathway";"RUNX3 regulates NOTCH signaling";"HATs acetylate histones";"NOTCH3 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" lcl|NW_020311994.1_prot_XP_012267465.1_21792 2 KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753 "Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism" lcl|NW_020311943.1_prot_XP_012255093.1_11746 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311315.1_prot_XP_020711115.1_3114 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311513.1_prot_XP_012266066.1_9822 2 Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" lcl|NW_020311292.1_prot_XP_020710277.1_704 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311360.1_prot_XP_020706625.1_5737 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311964.1_prot_XP_012262006.1_13960 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311292.1_prot_XP_012252412.1_565 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311514.1_prot_XP_025602191.1_9926 6 MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782 "Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311966.1_prot_XP_012256818.1_15178 4 Reactome: R-HSA-5660862;Reactome: R-HSA-352230;Reactome: R-HSA-71240;Reactome: R-HSA-210991 "Defective SLC7A7 causes lysinuric protein intolerance (LPI)";"Amino acid transport across the plasma membrane";"Tryptophan catabolism";"Basigin interactions" lcl|NW_020311976.1_prot_XP_012253628.1_17321 2 Reactome: R-HSA-8936459;Reactome: R-HSA-3214841 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines" lcl|NW_020311983.1_prot_XP_012268324.1_19552 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311364.1_prot_XP_012258905.1_5902 6 MetaCyc: PWY-7346;KEGG: 00053+1.1.1.22;KEGG: 00040+1.1.1.22;MetaCyc: PWY-7820;Reactome: R-HSA-173599;KEGG: 00520+1.1.1.22 "UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)";"Ascorbate and aldarate metabolism";"Pentose and glucuronate interconversions";"Teichuronic acid biosynthesis (B. subtilis 168)";"Formation of the active cofactor, UDP-glucuronate";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311973.1_prot_XP_012258546.1_16562 1 Reactome: R-HSA-193648 "NRAGE signals death through JNK" lcl|NW_020311977.1_prot_XP_020710692.1_17893 5 Reactome: R-HSA-350054;Reactome: R-HSA-5083630;Reactome: R-HSA-1912399;Reactome: R-HSA-1912420;Reactome: R-HSA-1912408 "Notch-HLH transcription pathway";"Defective LFNG causes SCDO3";"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Pre-NOTCH Processing in Golgi";"Pre-NOTCH Transcription and Translation" lcl|NW_020311966.1_prot_XP_012257165.1_14807 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311291.1_prot_XP_025601794.1_463 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" lcl|NW_020311976.1_prot_XP_020707180.1_17279 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311955.1_prot_XP_020711206.1_12444 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311981.1_prot_XP_012257533.1_19040 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311982.1_prot_XP_020708783.1_19292 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311982.1_prot_XP_012264644.1_19381 1 Reactome: R-HSA-399956 "CRMPs in Sema3A signaling" lcl|NW_020311982.1_prot_XP_012258241.1_19252 11 KEGG: 05170+2.7.11.1;Reactome: R-HSA-171007;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-4420097;Reactome: R-HSA-2559580;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-450302;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"p38MAPK events";"mTOR signaling pathway";"Relaxin signaling pathway";"Thermogenesis";"VEGFA-VEGFR2 Pathway";"Oxidative Stress Induced Senescence";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"activated TAK1 mediates p38 MAPK activation";"Human papillomavirus infection" lcl|NW_020311383.1_prot_XP_012251555.1_6884 12 Reactome: R-HSA-73863;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-73772;Reactome: R-HSA-73980;Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-73762;Reactome: R-HSA-73780;Reactome: R-HSA-76066 "RNA Polymerase I Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase I Promoter Escape";"RNA Polymerase III Transcription Termination";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase I Transcription Initiation";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" lcl|NW_020311364.1_prot_XP_020708945.1_5899 6 MetaCyc: PWY-7346;KEGG: 00053+1.1.1.22;Reactome: R-HSA-173599;MetaCyc: PWY-7820;KEGG: 00520+1.1.1.22;KEGG: 00040+1.1.1.22 "UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)";"Ascorbate and aldarate metabolism";"Formation of the active cofactor, UDP-glucuronate";"Teichuronic acid biosynthesis (B. subtilis 168)";"Amino sugar and nucleotide sugar metabolism";"Pentose and glucuronate interconversions" lcl|NW_020311966.1_prot_XP_020708142.1_14867 25 Reactome: R-HSA-8941284;Reactome: R-HSA-9616222;Reactome: R-HSA-8949275;Reactome: R-HSA-8939242;Reactome: R-HSA-8939246;Reactome: R-HSA-8934593;Reactome: R-HSA-8936459;Reactome: R-HSA-8951936;Reactome: R-HSA-8939247;Reactome: R-HSA-8941858;Reactome: R-HSA-8935964;Reactome: R-HSA-8939236;Reactome: R-HSA-8939245;Reactome: R-HSA-8940973;Reactome: R-HSA-9018519;Reactome: R-HSA-8951911;Reactome: R-HSA-8931987;Reactome: R-HSA-8939902;Reactome: R-HSA-8941332;Reactome: R-HSA-8941326;Reactome: R-HSA-8939256;Reactome: R-HSA-8941333;Reactome: R-HSA-8939243;Reactome: R-HSA-8877330;Reactome: R-HSA-8878166 "RUNX2 regulates chondrocyte maturation";"Transcriptional regulation of granulopoiesis";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX3 regulates p14-ARF";"RUNX1 regulates transcription of genes involved in interleukin signaling";"Regulation of RUNX3 expression and activity";"RUNX1 regulates expression of components of tight junctions";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX2 regulates osteoblast differentiation";"Estrogen-dependent gene expression";"RUNX3 regulates RUNX1-mediated transcription";"RUNX1 regulates estrogen receptor mediated transcription";"Regulation of RUNX2 expression and activity";"RUNX2 regulates genes involved in cell migration";"RUNX2 regulates bone development";"RUNX1 regulates transcription of genes involved in WNT signaling";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"Transcriptional regulation by RUNX2" lcl|NW_020311961.1_prot_XP_012262472.1_13348 9 Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-167161 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"HIV Transcription Initiation" lcl|NW_020311304.1_prot_XP_012260855.1_1803 27 Reactome: R-HSA-9610379;Reactome: R-HSA-170822;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-5619107;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-3108214;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-3301854;Reactome: R-HSA-159227;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-9609690;Reactome: R-HSA-4615885;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-165054;Reactome: R-HSA-180910 "HCMV Late Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"SUMOylation of DNA damage response and repair proteins";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP independent Mature mRNA";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"HCMV Early Events";"SUMOylation of DNA replication proteins";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"Rev-mediated nuclear export of HIV RNA";"Vpr-mediated nuclear import of PICs" lcl|NW_020311432.1_prot_XP_012268883.1_8312 18 Reactome: R-HSA-6790901;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-166208 "rRNA modification in the nucleus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"mTORC1-mediated signalling" lcl|NW_020311988.1_prot_XP_012261207.1_20666 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311312.1_prot_XP_020711705.1_2762 5 Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-917729;Reactome: R-HSA-174490;Reactome: R-HSA-9615710 "HCMV Late Events";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy" lcl|NW_020311285.1_prot_XP_012256109.1_33 5 Reactome: R-HSA-5610787;Reactome: R-HSA-5610783;Reactome: R-HSA-5610780;Reactome: R-HSA-5610785;Reactome: R-HSA-5632684 "Hedgehog 'off' state";"Degradation of GLI2 by the proteasome";"Degradation of GLI1 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog 'on' state" lcl|NW_020311946.1_prot_XP_012268644.1_11922 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311973.1_prot_XP_012258746.1_16381 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311593.1_prot_XP_012254371.1_10065 18 Reactome: R-HSA-167238;Reactome: R-HSA-167242;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-167158;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-113418;Reactome: R-HSA-72086 "Pausing and recovery of Tat-mediated HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"Formation of the Early Elongation Complex";"mRNA Capping" lcl|NW_020311956.1_prot_XP_020706563.1_12637 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311294.1_prot_XP_012264944.1_859 5 KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;Reactome: R-HSA-389661;MetaCyc: PWY-5084 "Citrate cycle (TCA cycle)";"Lysine degradation";"Tryptophan metabolism";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA" lcl|NW_020311313.1_prot_XP_012261652.1_2842 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311971.1_prot_XP_012260843.1_15897 3 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311975.1_prot_XP_012254255.1_17010 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311981.1_prot_XP_012257468.1_18974 3 Reactome: R-HSA-5696400;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135 "Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER" lcl|NW_020311962.1_prot_XP_012251968.1_13773 4 KEGG: 00513+2.4.1.131;KEGG: 00510+2.4.1.131;Reactome: R-HSA-446193;Reactome: R-HSA-4551295 "Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG11 causes ALG11-CDG (CDG-1p)" lcl|NW_020311984.1_prot_XP_012267685.1_20150 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311959.1_prot_XP_012262392.1_13078 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" lcl|NW_020311982.1_prot_XP_020708782.1_19290 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311966.1_prot_XP_012253023.1_14548 2 KEGG: 00340+2.1.1.22;Reactome: R-HSA-70921 "Histidine metabolism";"Histidine catabolism" lcl|NW_020311985.1_prot_XP_012265258.1_20238 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311965.1_prot_XP_012259673.1_14312 8 MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142;MetaCyc: PWY-5744;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-241;MetaCyc: PWY-7117 "3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glyoxylate assimilation";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type" lcl|NW_020311973.1_prot_XP_020708859.1_16357 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311993.1_prot_XP_012263009.1_21430 3 Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311513.1_prot_XP_020711464.1_9873 4 Reactome: R-HSA-5358493;MetaCyc: PWY-6482;MetaCyc: PWY-7546;Reactome: R-HSA-8849175 "Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)";"Threonine catabolism" lcl|NW_020311981.1_prot_XP_012257436.1_18946 8 Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-8866652;Reactome: R-HSA-6804757;Reactome: R-HSA-8948747;Reactome: R-HSA-5689880;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823 "Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Regulation of TP53 Degradation";"Regulation of PTEN localization";"Ub-specific processing proteases";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex" lcl|NW_020311979.1_prot_XP_020709213.1_18558 8 KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Human papillomavirus infection";"Activation of RAC1";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311381.1_prot_XP_012252309.2_6793 11 Reactome: R-HSA-170670;Reactome: R-HSA-418597;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-418555;Reactome: R-HSA-164378 "Adenylate cyclase inhibitory pathway";"G alpha (z) signalling events";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase activating pathway";"PKA activation";"Glucagon signaling in metabolic regulation";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (s) signalling events";"PKA activation in glucagon signalling" lcl|NW_020311292.1_prot_XP_012252512.1_582 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311870.1_prot_XP_025602242.1_10113 3 KEGG: 00195+7.1.2.2;MetaCyc: PWY-7980;KEGG: 00190+7.1.2.2 "Photosynthesis";"ATP biosynthesis";"Oxidative phosphorylation" lcl|NW_020311995.1_prot_XP_012257206.1_22012 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311393.1_prot_XP_012265745.1_7150 7 KEGG: 00240+3.5.2.3;MetaCyc: PWY-7791;MetaCyc: PWY-5686;MetaCyc: PWY-7790;KEGG: 00230+3.5.2.5;MetaCyc: PWY-5698;MetaCyc: PWY-5697 "Pyrimidine metabolism";"UMP biosynthesis III";"UMP biosynthesis I";"UMP biosynthesis II";"Purine metabolism";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Allantoin degradation to ureidoglycolate I (urea producing)" lcl|NW_020311380.1_prot_XP_012268192.1_6735 3 KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154 "Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase" lcl|NW_020311974.1_prot_XP_012260111.1_16865 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311373.1_prot_XP_012262968.1_6410 1 Reactome: R-HSA-111957 "Cam-PDE 1 activation" lcl|NW_020311321.1_prot_XP_012263210.1_3407 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311339.1_prot_XP_012254291.1_4642 7 Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-4615885;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"SUMOylation of DNA replication proteins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311320.1_prot_XP_012267573.1_3377 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" lcl|NW_020311994.1_prot_XP_025603020.1_21509 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311976.1_prot_XP_020707258.1_17283 2 KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749 "Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I" lcl|NW_020311958.1_prot_XP_020708070.1_12993 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311977.1_prot_XP_012263658.1_17734 2 KEGG: 00970+6.1.1.5;Reactome: R-HSA-379726 "Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" lcl|NW_020311958.1_prot_XP_025602455.1_12911 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311985.1_prot_XP_012253978.1_20301 3 Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916 "Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium" lcl|NW_020311391.1_prot_XP_025601971.1_7046 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311936.1_prot_XP_012261267.1_11012 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311967.1_prot_XP_012254314.1_15334 11 Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-212436;Reactome: R-HSA-400206;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-2426168;Reactome: R-HSA-1368108;Reactome: R-HSA-383280;Reactome: R-HSA-2151201 "Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"RORA activates gene expression";"Generic Transcription Pathway";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression";"Estrogen-dependent gene expression";"Activation of gene expression by SREBF (SREBP)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nuclear Receptor transcription pathway";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311979.1_prot_XP_020709232.1_18543 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311312.1_prot_XP_012266797.1_2611 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311979.1_prot_XP_012259580.1_18574 6 Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-72702 "Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition" lcl|NW_020311983.1_prot_XP_012255538.1_19646 15 Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5693548;Reactome: R-HSA-5693571;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-5693568;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-5685939;Reactome: R-HSA-2559586;Reactome: R-HSA-5685938 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Sensing of DNA Double Strand Breaks";"Nonhomologous End-Joining (NHEJ)";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic recombination";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"HDR through MMEJ (alt-NHEJ)";"DNA Damage/Telomere Stress Induced Senescence";"HDR through Single Strand Annealing (SSA)" lcl|NW_020311994.1_prot_XP_020711882.1_21602 4 Reactome: R-HSA-499943;MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541 "Interconversion of nucleotide di- and triphosphates";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Abacavir metabolism" lcl|NW_020311353.1_prot_XP_012255972.1_5457 11 KEGG: 05165+2.7.11.1;Reactome: R-HSA-9614657;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-163680;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-380972;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6804756 "Human papillomavirus infection";"FOXO-mediated transcription of cell death genes";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"AMPK inhibits chREBP transcriptional activation activity";"Thermogenesis";"Relaxin signaling pathway";"mTOR signaling pathway";"Energy dependent regulation of mTOR by LKB1-AMPK";"Human immunodeficiency virus 1 infection";"Regulation of TP53 Activity through Phosphorylation" lcl|NW_020311287.1_prot_XP_012268132.1_325 8 Reactome: R-HSA-3214841;Reactome: R-HSA-9609690;Reactome: R-HSA-2559580;Reactome: R-HSA-8953750;Reactome: R-HSA-4551638;Reactome: R-HSA-5617472;Reactome: R-HSA-212300;Reactome: R-HSA-8943724 "PKMTs methylate histone lysines";"HCMV Early Events";"Oxidative Stress Induced Senescence";"Transcriptional Regulation by E2F6";"SUMOylation of chromatin organization proteins";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PRC2 methylates histones and DNA";"Regulation of PTEN gene transcription" lcl|NW_020311941.1_prot_XP_012253214.1_11412 1 Reactome: R-HSA-427413 "NoRC negatively regulates rRNA expression" lcl|NW_020311318.1_prot_XP_020707252.1_3306 2 Reactome: R-HSA-5620924;Reactome: R-HSA-5610787 "Intraflagellar transport";"Hedgehog 'off' state" lcl|NW_020311332.1_prot_XP_012256292.1_4159 1 KEGG: 00230+4.6.1.2 "Purine metabolism" lcl|NW_020311302.1_prot_XP_020710867.1_1673 3 Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961 "Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II" lcl|NW_020311324.1_prot_XP_012269429.1_3583 3 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311970.1_prot_XP_012256838.1_15707 10 Reactome: R-HSA-111463;Reactome: R-HSA-2151201;Reactome: R-HSA-611105;Reactome: R-HSA-111457;Reactome: R-HSA-9627069;Reactome: R-HSA-111459;Reactome: R-HSA-111458;Reactome: R-HSA-3299685;Reactome: R-HSA-111464;Reactome: R-HSA-5628897 "SMAC (DIABLO) binds to IAPs";"Transcriptional activation of mitochondrial biogenesis";"Respiratory electron transport";"Release of apoptotic factors from the mitochondria";"Regulation of the apoptosome activity";"Activation of caspases through apoptosome-mediated cleavage";"Formation of apoptosome";"Detoxification of Reactive Oxygen Species";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"TP53 Regulates Metabolic Genes" lcl|NW_020311304.1_prot_XP_012261412.1_1895 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311298.1_prot_XP_012269939.1_1194 5 MetaCyc: PWY-6277;Reactome: R-HSA-73817;MetaCyc: PWY-6122;MetaCyc: PWY-6121;KEGG: 00230+6.3.5.3 "Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism" lcl|NW_020311953.1_prot_XP_012260525.1_12288 15 Reactome: R-HSA-5339716;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5467348;Reactome: R-HSA-5358747;Reactome: R-HSA-111465;Reactome: R-HSA-5467333;Reactome: R-HSA-5358749;Reactome: R-HSA-5358752;Reactome: R-HSA-4641262;Reactome: R-HSA-5467337;Reactome: R-HSA-3769402;Reactome: R-HSA-5689896;Reactome: R-HSA-196299;Reactome: R-HSA-5358751 "Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"Truncations of AMER1 destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"Apoptotic cleavage of cellular proteins";"APC truncation mutants are not K63 polyubiquitinated";"S37 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"APC truncation mutants have impaired AXIN binding";"Deactivation of the beta-catenin transactivating complex";"Ovarian tumor domain proteases";"Beta-catenin phosphorylation cascade";"S45 mutants of beta-catenin aren't phosphorylated" lcl|NW_020311978.1_prot_XP_012257759.1_18200 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311304.1_prot_XP_012260415.1_1945 2 Reactome: R-HSA-6798695;Reactome: R-HSA-8964038 "Neutrophil degranulation";"LDL clearance" lcl|NW_020311448.1_prot_XP_012252662.1_8975 27 Reactome: R-HSA-4085377;Reactome: R-HSA-4615885;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-4551638;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-5619107;Reactome: R-HSA-168271;Reactome: R-HSA-159230;Reactome: R-HSA-168333;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-159227;Reactome: R-HSA-3301854;Reactome: R-HSA-180746;Reactome: R-HSA-3232142 "SUMOylation of SUMOylation proteins";"SUMOylation of DNA replication proteins";"HCMV Early Events";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of chromatin organization proteins";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP Dependant Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins" lcl|NW_020311323.1_prot_XP_012267992.1_3460 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311979.1_prot_XP_012259573.1_18628 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection" lcl|NW_020311994.1_prot_XP_025603005.1_21727 2 KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600 "Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" lcl|NW_020311292.1_prot_XP_020706866.1_554 4 KEGG: 00030+1.1.1.49;MetaCyc: PWY-8004;KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268 "Pentose phosphate pathway";"Entner-Doudoroff pathway I";"Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)" lcl|NW_020311539.1_prot_XP_012262314.1_9988 57 Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-5668541;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-9010553;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-349425;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-5689603;Reactome: R-HSA-450408 "SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of RAS by GAPs";"TNFR2 non-canonical NF-kB pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"Regulation of expression of SLITs and ROBOs";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Degradation of DVL";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA" lcl|NW_020311974.1_prot_XP_012259890.1_16914 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311978.1_prot_XP_020708581.1_18053 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311356.1_prot_XP_012267111.1_5538 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311966.1_prot_XP_012252941.1_14423 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311371.1_prot_XP_025601906.1_6296 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" lcl|NW_020311619.1_prot_XP_012260697.1_10083 23 Reactome: R-HSA-418597;Reactome: R-HSA-428930;Reactome: R-HSA-202040;Reactome: R-HSA-418592;Reactome: R-HSA-381676;Reactome: R-HSA-500657;Reactome: R-HSA-418555;Reactome: R-HSA-9009391;Reactome: R-HSA-392170;Reactome: R-HSA-8964616;Reactome: R-HSA-400042;Reactome: R-HSA-392851;Reactome: R-HSA-392451;Reactome: R-HSA-420092;Reactome: R-HSA-418217;Reactome: R-HSA-416476;Reactome: R-HSA-8964315;Reactome: R-HSA-6814122;Reactome: R-HSA-416482;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-4086398;Reactome: R-HSA-456926 "G alpha (z) signalling events";"Thromboxane signalling through TP receptor";"G-protein activation";"ADP signalling through P2Y purinoceptor 1";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Presynaptic function of Kainate receptors";"G alpha (s) signalling events";"Extra-nuclear estrogen signaling";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through CDC42";"Adrenaline,noradrenaline inhibits insulin secretion";"Prostacyclin signalling through prostacyclin receptor";"G beta:gamma signalling through PI3Kgamma";"Glucagon-type ligand receptors";"G beta:gamma signalling through PLC beta";"G alpha (q) signalling events";"G beta:gamma signalling through BTK";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (12/13) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Ca2+ pathway";"Thrombin signalling through proteinase activated receptors (PARs)" lcl|NW_020311978.1_prot_XP_012257851.1_18202 2 Reactome: R-HSA-8869496;Reactome: R-HSA-1268020 "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation";"Mitochondrial protein import" lcl|NW_020311349.1_prot_XP_012251239.1_5304 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311984.1_prot_XP_020710934.1_19820 8 KEGG: 00640+1.1.1.27;MetaCyc: PWY-5481;KEGG: 00010+1.1.1.27;MetaCyc: PWY-8086;KEGG: 00620+1.1.1.27;KEGG: 00270+1.1.1.27;Reactome: R-HSA-70268;MetaCyc: PWY-6901 "Propanoate metabolism";"Pyruvate fermentation to (S)-lactate";"Glycolysis / Gluconeogenesis";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Cysteine and methionine metabolism";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation" lcl|NW_020311948.1_prot_XP_012253529.1_12019 2 KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10 "One carbon pool by folate";"Glycine, serine and threonine metabolism" lcl|NW_020311321.1_prot_XP_012263203.1_3409 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311447.1_prot_XP_020706805.1_8965 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311446.1_prot_XP_012261164.1_8950 5 Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-917729;Reactome: R-HSA-174490;Reactome: R-HSA-9615710 "HCMV Late Events";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy" lcl|NW_020311982.1_prot_XP_012258236.1_19256 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311978.1_prot_XP_025602777.1_18059 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311477.1_prot_XP_012262341.1_9444 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" lcl|NW_020311286.1_prot_XP_012257191.1_101 2 Reactome: R-HSA-6807505;Reactome: R-HSA-72163 "RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway" lcl|NW_020311423.1_prot_XP_012251571.1_8173 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311513.1_prot_XP_012266198.1_9898 3 Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-159230 "RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"Transport of the SLBP Dependant Mature mRNA" lcl|NW_020311967.1_prot_XP_012256040.1_15207 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311286.1_prot_XP_020708271.1_152 14 Reactome: R-HSA-1483166;MetaCyc: PWY-7782;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5667;MetaCyc: PWY-7587;MetaCyc: PWY-6453;MetaCyc: PWY-7417;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-5981;MetaCyc: PWY-7411;MetaCyc: PWY-7589;MetaCyc: PWY-8053;MetaCyc: PWY-8055 "Synthesis of PA";"Plasmalogen biosynthesis";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Palmitoleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis" lcl|NW_020311967.1_prot_XP_012256024.1_15253 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311964.1_prot_XP_020709948.1_14024 6 Reactome: R-HSA-6796648;Reactome: R-HSA-5358606;Reactome: R-HSA-5632987;Reactome: R-HSA-912446;Reactome: R-HSA-5545483;Reactome: R-HSA-5358565 "TP53 Regulates Transcription of DNA Repair Genes";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With PMS2";"Meiotic recombination";"Defective Mismatch Repair Associated With MLH1";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)" lcl|NW_020311971.1_prot_XP_020709612.1_15829 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311918.1_prot_XP_020710215.1_10303 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" lcl|NW_020311919.1_prot_XP_012257631.1_10492 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" lcl|NW_020311371.1_prot_XP_025601905.1_6297 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" lcl|NW_020311968.1_prot_XP_025602615.1_15398 9 Reactome: R-HSA-3656253;Reactome: R-HSA-975634;Reactome: R-HSA-3560801;Reactome: R-HSA-4420332;Reactome: R-HSA-2022928;Reactome: R-HSA-1971475;Reactome: R-HSA-3560783;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096 "Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Retinoid metabolism and transport";"Defective B3GAT3 causes JDSSDHD";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"HS-GAG biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B4GALT7 causes EDS, progeroid type";"Defective EXT2 causes exostoses 2";"HS-GAG degradation" lcl|NW_020311982.1_prot_XP_020708775.1_19194 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" lcl|NW_020311401.1_prot_XP_012255239.1_7588 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311983.1_prot_XP_012255553.1_19736 2 Reactome: R-HSA-5689896;Reactome: R-HSA-195253 "Ovarian tumor domain proteases";"Degradation of beta-catenin by the destruction complex" lcl|NW_020311983.1_prot_XP_012255628.1_19807 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311317.1_prot_XP_012253988.1_3238 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311306.1_prot_XP_012264196.1_2077 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311334.1_prot_XP_020711370.1_4368 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311424.1_prot_XP_012255450.1_8182 4 Reactome: R-HSA-400511;Reactome: R-HSA-1799339;Reactome: R-HSA-422085;Reactome: R-HSA-381771 "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)" lcl|NW_020311994.1_prot_XP_012262163.1_21836 13 KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-1660662;Reactome: R-HSA-2160916;MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2024101;MetaCyc: PWY-7822;MetaCyc: PWY-6902;Reactome: R-HSA-2022857 "Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Various types of N-glycan biosynthesis";"Glycosphingolipid metabolism";"Hyaluronan uptake and degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series";"CS/DS degradation";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Keratan sulfate degradation" lcl|NW_020311368.1_prot_XP_012264401.1_6198 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311918.1_prot_XP_012265016.1_10458 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311286.1_prot_XP_012256557.1_170 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311313.1_prot_XP_020709998.1_2956 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" lcl|NW_020311941.1_prot_XP_012253219.1_11414 1 Reactome: R-HSA-8851805 "MET activates RAS signaling" lcl|NW_020311962.1_prot_XP_012252005.1_13710 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311331.1_prot_XP_012264357.1_4063 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311977.1_prot_XP_012264030.1_17779 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311326.1_prot_XP_012261521.1_3728 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311294.1_prot_XP_020711020.1_874 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311967.1_prot_XP_025602607.1_15257 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311296.1_prot_XP_012265197.1_998 2 Reactome: R-HSA-8936459;Reactome: R-HSA-3214841 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines" lcl|NW_020311373.1_prot_XP_012266725.1_6477 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311396.1_prot_XP_020706141.1_7264 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311292.1_prot_XP_012252472.1_498 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" lcl|NW_020311979.1_prot_XP_012259493.1_18561 1 Reactome: R-HSA-5676934 "Protein repair" lcl|NW_020311978.1_prot_XP_025602774.1_18054 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311988.1_prot_XP_012269521.1_20541 14 MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-7782;KEGG: 00561+2.3.1.51;Reactome: R-HSA-1483166;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-7417;MetaCyc: PWY-7589;MetaCyc: PWY-7411;MetaCyc: PWY-5981;MetaCyc: PWY-8055;MetaCyc: PWY-8053 "Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Plasmalogen biosynthesis";"Glycerolipid metabolism";"Synthesis of PA";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Palmitoleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II" lcl|NW_020311985.1_prot_XP_025602915.1_20203 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311432.1_prot_XP_012268806.1_8372 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311978.1_prot_XP_020708698.1_18368 3 Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916 "Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium" lcl|NW_020311980.1_prot_XP_012261263.1_18775 3 Reactome: R-HSA-611105;Reactome: R-HSA-1268020;Reactome: R-HSA-6799198 "Respiratory electron transport";"Mitochondrial protein import";"Complex I biogenesis" lcl|NW_020311397.1_prot_XP_012258206.1_7304 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" lcl|NW_020311417.1_prot_XP_025602024.1_7956 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" lcl|NW_020311993.1_prot_XP_012262918.1_21380 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311966.1_prot_XP_020708086.1_14950 7 Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025 "RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311979.1_prot_XP_020709264.1_18626 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311296.1_prot_XP_012265447.1_1009 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311983.1_prot_XP_012267252.1_19416 13 KEGG: 00982+2.5.1.18;KEGG: 00480+2.5.1.18+1.8.5.1;MetaCyc: PWY-4061;MetaCyc: PWY-2261;KEGG: 00980+2.5.1.18;MetaCyc: PWY-6370;KEGG: 00053+1.8.5.1;MetaCyc: PWY-6842;Reactome: R-HSA-196836;Reactome: R-HSA-156590;MetaCyc: PWY-7533;MetaCyc: PWY-7112;KEGG: 00983+2.5.1.18 "Drug metabolism - cytochrome P450";"Glutathione metabolism";"Glutathione-mediated detoxification I";"Ascorbate glutathione cycle";"Metabolism of xenobiotics by cytochrome P450";"Ascorbate recycling (cytosolic)";"Ascorbate and aldarate metabolism";"Glutathione-mediated detoxification II";"Vitamin C (ascorbate) metabolism";"Glutathione conjugation";"Gliotoxin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Drug metabolism - other enzymes" lcl|NW_020311989.1_prot_XP_012263186.1_20776 1 Reactome: R-HSA-446193 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" lcl|NW_020311986.1_prot_XP_012258892.1_20340 1 Reactome: R-HSA-480985 "Synthesis of dolichyl-phosphate-glucose" lcl|NW_020311936.1_prot_XP_012261354.1_10996 5 KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341;Reactome: R-HSA-450321;Reactome: R-HSA-2871796;Reactome: R-HSA-2559580 "mTOR signaling pathway";"Activation of the AP-1 family of transcription factors";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"FCERI mediated MAPK activation";"Oxidative Stress Induced Senescence" lcl|NW_020311961.1_prot_XP_020710181.1_13533 5 Reactome: R-HSA-6804758;Reactome: R-HSA-73762;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815;Reactome: R-HSA-427389 "Regulation of TP53 Activity through Acetylation";"RNA Polymerase I Transcription Initiation";"Regulation of PTEN gene transcription";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" lcl|NW_020311344.1_prot_XP_012252329.1_4879 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311354.1_prot_XP_025601843.1_5472 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311977.1_prot_XP_025602763.1_17917 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311381.1_prot_XP_020706785.1_6792 11 KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-170670;Reactome: R-HSA-418597;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-418594;Reactome: R-HSA-432040 "Purine metabolism";"Adenylate cyclase activating pathway";"Adenylate cyclase inhibitory pathway";"G alpha (z) signalling events";"Hedgehog 'off' state";"PKA activation";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins" lcl|NW_020311302.1_prot_XP_012264585.1_1647 4 Reactome: R-HSA-9020702;Reactome: R-HSA-937039;MetaCyc: PWY-7511;Reactome: R-HSA-975144 "Interleukin-1 signaling";"IRAK1 recruits IKK complex";"Protein ubiquitination";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation" lcl|NW_020311432.1_prot_XP_012268718.1_8450 4 Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387 "Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling" lcl|NW_020311353.1_prot_XP_012256044.1_5392 1 Reactome: R-HSA-880009 "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" lcl|NW_020311377.1_prot_XP_012260446.1_6593 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" lcl|NW_020311971.1_prot_XP_020710532.1_16085 12 Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436 "Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311936.1_prot_XP_012261355.1_10990 5 Reactome: R-HSA-2559580;Reactome: R-HSA-2871796;Reactome: R-HSA-450321;Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24 "Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"mTOR signaling pathway" lcl|NW_020311979.1_prot_XP_012259563.1_18480 8 KEGG: 04150+2.7.11.1;Reactome: R-HSA-975957;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway" lcl|NW_020311975.1_prot_XP_012252642.1_17100 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311959.1_prot_XP_012262375.1_13114 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311983.1_prot_XP_012267193.1_19480 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311992.1_prot_XP_025602969.1_21214 2 Reactome: R-HSA-6798695;Reactome: R-HSA-983168 "Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311979.1_prot_XP_012261445.1_18681 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311289.1_prot_XP_012253946.1_367 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311315.1_prot_XP_012265177.1_3097 1 Reactome: R-HSA-8866654 "E3 ubiquitin ligases ubiquitinate target proteins" lcl|NW_020311359.1_prot_XP_012252064.1_5714 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311980.1_prot_XP_020709780.1_18788 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311396.1_prot_XP_020712536.1_7248 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311393.1_prot_XP_012265779.1_7204 10 KEGG: 00051+2.7.1.11;KEGG: 00010+2.7.1.11;MetaCyc: PWY-1042;MetaCyc: PWY-5484;KEGG: 00030+2.7.1.11;MetaCyc: PWY-1861;Reactome: R-HSA-70171;MetaCyc: PWY-7385;KEGG: 00680+2.7.1.11;KEGG: 00052+2.7.1.11 "Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism";"Galactose metabolism" lcl|NW_020311364.1_prot_XP_012258870.1_5915 56 Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610785;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-8951664;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-174084;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-5668541 "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ub-specific processing proteases";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Interleukin-1 signaling";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"GLI3 is processed to GLI3R by the proteasome";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Neddylation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Regulation of RAS by GAPs";"G2/M Checkpoints";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Autodegradation of Cdh1 by Cdh1:APC/C";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"TNFR2 non-canonical NF-kB pathway" lcl|NW_020311972.1_prot_XP_012264678.1_16305 27 Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-3301854;Reactome: R-HSA-159227;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-159230;Reactome: R-HSA-168333;Reactome: R-HSA-5619107;Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-4570464;Reactome: R-HSA-3108214;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-6784531;Reactome: R-HSA-4551638;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-4615885 "SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"Transport of the SLBP Dependant Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of RNA binding proteins";"SUMOylation of DNA damage response and repair proteins";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"tRNA processing in the nucleus";"SUMOylation of chromatin organization proteins";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"HCMV Early Events";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"SUMOylation of DNA replication proteins" lcl|NW_020311302.1_prot_XP_012264526.1_1648 3 Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311985.1_prot_XP_012265235.1_20197 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311424.1_prot_XP_012255439.1_8180 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311943.1_prot_XP_012255053.1_11571 4 Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568 "HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311965.1_prot_XP_020709473.1_14185 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.15 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311977.1_prot_XP_012263954.1_18029 14 MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199 "Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation" lcl|NW_020311961.1_prot_XP_012262618.1_13531 5 Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-6804758;Reactome: R-HSA-8943724;Reactome: R-HSA-73762 "HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation" lcl|NW_020311983.1_prot_XP_020711785.1_19447 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" lcl|NW_020311325.1_prot_XP_012251451.1_3674 7 Reactome: R-HSA-381033;Reactome: R-HSA-114608;Reactome: R-HSA-381070;Reactome: R-HSA-381042;Reactome: R-HSA-983170;Reactome: R-HSA-381183;Reactome: R-HSA-3371453 "ATF6 (ATF6-alpha) activates chaperones";"Platelet degranulation";"IRE1alpha activates chaperones";"PERK regulates gene expression";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"ATF6 (ATF6-alpha) activates chaperone genes";"Regulation of HSF1-mediated heat shock response" lcl|NW_020311292.1_prot_XP_012262801.1_707 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311292.1_prot_XP_020710264.1_690 4 Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-419037 "Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"NCAM1 interactions" lcl|NW_020311321.1_prot_XP_012263247.1_3440 2 Reactome: R-HSA-3928665;Reactome: R-HSA-2682334 "EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling" lcl|NW_020311967.1_prot_XP_020708010.1_15223 5 Reactome: R-HSA-112409;Reactome: R-HSA-5675221;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "RAF-independent MAPK1/3 activation";"Negative regulation of MAPK pathway";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311325.1_prot_XP_012251287.2_3660 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311436.1_prot_XP_020708799.2_8799 4 Reactome: R-HSA-212300;KEGG: 00270+2.1.1.37;Reactome: R-HSA-5334118;Reactome: R-HSA-4655427 "PRC2 methylates histones and DNA";"Cysteine and methionine metabolism";"DNA methylation";"SUMOylation of DNA methylation proteins" lcl|NW_020311932.1_prot_XP_012257420.1_10716 6 KEGG: 00562+3.1.3.36;Reactome: R-HSA-194840;Reactome: R-HSA-1855183;Reactome: R-HSA-1855204;KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368 "Inositol phosphate metabolism";"Rho GTPase cycle";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation" lcl|NW_020311315.1_prot_XP_025603065.1_3099 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" lcl|NW_020311349.1_prot_XP_012251160.1_5331 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311391.1_prot_XP_012256740.1_7028 2 Reactome: R-HSA-432720;Reactome: R-HSA-432722 "Lysosome Vesicle Biogenesis";"Golgi Associated Vesicle Biogenesis" lcl|NW_020311971.1_prot_XP_012263578.1_16123 2 Reactome: R-HSA-190873;Reactome: R-HSA-399719 "Gap junction degradation";"Trafficking of AMPA receptors" lcl|NW_020311433.1_prot_XP_012263743.1_8669 2 Reactome: R-HSA-446199;Reactome: R-HSA-4755609 "Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59" lcl|NW_020311334.1_prot_XP_012265866.1_4402 1 Reactome: R-HSA-2129379 "Molecules associated with elastic fibres" lcl|NW_020311292.1_prot_XP_012252437.1_593 13 Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72706 "Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311967.1_prot_XP_020707515.1_15284 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311287.1_prot_XP_012268113.1_261 4 KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-6483;MetaCyc: PWY-7119 "Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)" lcl|NW_020311308.1_prot_XP_012253330.1_2222 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311981.1_prot_XP_012257467.1_18973 3 Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-5696400 "Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Dual Incision in GG-NER" lcl|NW_020311988.1_prot_XP_025602941.1_20739 14 MetaCyc: PWY-5972;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-7601 "Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)" lcl|NW_020311432.1_prot_XP_012268928.1_8560 2 Reactome: R-HSA-6814122;Reactome: R-HSA-418594 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events" lcl|NW_020311962.1_prot_XP_012252014.1_13804 10 MetaCyc: PWY-5484;MetaCyc: PWY-6886;Reactome: R-HSA-70171;KEGG: 00710+2.7.2.3;MetaCyc: PWY-7003;MetaCyc: PWY-8004;KEGG: 00010+2.7.2.3;Reactome: R-HSA-70263;MetaCyc: PWY-6901;MetaCyc: PWY-1042 "Glycolysis II (from fructose 6-phosphate)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis";"Carbon fixation in photosynthetic organisms";"Glycerol degradation to butanol";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Glycolysis IV (plant cytosol)" lcl|NW_020311380.1_prot_XP_012268187.1_6737 3 KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154 "Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase" lcl|NW_020311940.1_prot_XP_012265689.1_11252 2 Reactome: R-HSA-425393;Reactome: R-HSA-5223345 "Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events" lcl|NW_020311955.1_prot_XP_012265405.1_12391 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" lcl|NW_020311994.1_prot_XP_012267487.1_21724 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311298.1_prot_XP_012269883.1_1322 3 Reactome: R-HSA-2024101;Reactome: R-HSA-2206296;Reactome: R-HSA-2024096 "CS/DS degradation";"MPS II - Hunter syndrome";"HS-GAG degradation" lcl|NW_020311304.1_prot_XP_012261362.1_1873 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311975.1_prot_XP_020707580.1_17027 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311936.1_prot_XP_012261367.1_10988 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311974.1_prot_XP_012260013.1_16656 6 Reactome: R-HSA-388844;Reactome: R-HSA-264642;Reactome: R-HSA-212676;Reactome: R-HSA-210500;Reactome: R-HSA-181429;Reactome: R-HSA-181430 "Receptor-type tyrosine-protein phosphatases";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle" lcl|NW_020311984.1_prot_XP_012264707.1_19825 17 Reactome: R-HSA-69183;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-174411;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-5358606;Reactome: R-HSA-69091;Reactome: R-HSA-174437;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-5696400;Reactome: R-HSA-174417;Reactome: R-HSA-5358565;Reactome: R-HSA-5696397;Reactome: R-HSA-174414;Reactome: R-HSA-69166 "Processive synthesis on the lagging strand";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Polymerase switching on the C-strand of the telomere";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Polymerase switching";"Removal of the Flap Intermediate from the C-strand";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual Incision in GG-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Processive synthesis on the C-strand of the telomere";"Removal of the Flap Intermediate" lcl|NW_020311992.1_prot_XP_012266554.1_21262 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311993.1_prot_XP_012261766.1_21357 2 Reactome: R-HSA-6782315;MetaCyc: PWY-6829 "tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)" lcl|NW_020311917.1_prot_XP_020706421.1_10231 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311419.1_prot_XP_020707409.1_8072 1 Reactome: R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" lcl|NW_020311925.1_prot_XP_012252595.1_10539 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311955.1_prot_XP_012265389.1_12413 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" lcl|NW_020311991.1_prot_XP_012269805.1_20946 6 Reactome: R-HSA-5651801;Reactome: R-HSA-5685939;Reactome: R-HSA-162594;Reactome: R-HSA-110362;Reactome: R-HSA-69166;Reactome: R-HSA-174437 "PCNA-Dependent Long Patch Base Excision Repair";"HDR through MMEJ (alt-NHEJ)";"Early Phase of HIV Life Cycle";"POLB-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"Removal of the Flap Intermediate from the C-strand" lcl|NW_020311424.1_prot_XP_012255427.1_8234 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311981.1_prot_XP_025602852.1_18951 8 Reactome: R-HSA-8948747;Reactome: R-HSA-5689880;Reactome: R-HSA-8866652;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6804757;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823 "Regulation of PTEN localization";"Ub-specific processing proteases";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Regulation of TP53 Degradation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex" lcl|NW_020311285.1_prot_XP_012255878.1_11 1 KEGG: 00970+6.1.1.22 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311983.1_prot_XP_012268354.1_19632 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311943.1_prot_XP_012255320.1_11699 6 Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA" lcl|NW_020311424.1_prot_XP_012255446.1_8187 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311945.1_prot_XP_012269660.1_11819 13 MetaCyc: PWY-5030;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;KEGG: 00720+6.3.4.3;MetaCyc: PWY-1722;Reactome: R-HSA-196757;KEGG: 00670+1.5.1.5+3.5.4.9;KEGG: 00670+6.3.4.3;MetaCyc: PWY-7909;MetaCyc: PWY-6613;MetaCyc: PWY-5497;MetaCyc: PWY-2161;MetaCyc: PWY-2201 "L-histidine degradation III";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Metabolism of folate and pterines";"One carbon pool by folate";"One carbon pool by folate";"Formaldehyde oxidation VII (THF pathway)";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine nucleobases degradation II (anaerobic)";"Folate polyglutamylation";"Folate transformations I" lcl|NW_020311934.1_prot_XP_012255370.1_10853 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311401.1_prot_XP_012255293.1_7449 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311962.1_prot_XP_020706693.1_13657 2 MetaCyc: PWY-6854;Reactome: R-HSA-3299685 "Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species" lcl|NW_020311958.1_prot_XP_020707947.1_12933 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311968.1_prot_XP_012253063.1_15440 2 Reactome: R-HSA-1296072;Reactome: R-HSA-5576894 "Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels" lcl|NW_020311994.1_prot_XP_012267545.1_21689 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" lcl|NW_020311995.1_prot_XP_012256348.1_22028 1 Reactome: R-HSA-380320 "Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311974.1_prot_XP_020709332.1_16712 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311966.1_prot_XP_012251719.1_14577 19 Reactome: R-HSA-71403;Reactome: R-HSA-163765;Reactome: R-HSA-75105;MetaCyc: PWY-7384;MetaCyc: PWY-5172;KEGG: 00720+2.3.3.8;KEGG: 00020+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-5537;KEGG: 00020+2.3.3.8;Reactome: R-HSA-6798695;MetaCyc: PWY-5392;MetaCyc: PWY-6728;MetaCyc: PWY-5690;KEGG: 00660+6.2.1.5;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5538;MetaCyc: PWY-6969 "Citric acid cycle (TCA cycle)";"ChREBP activates metabolic gene expression";"Fatty acyl-CoA biosynthesis";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Acetyl-coa biosynthesis III (from citrate)";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)";"Pyruvate fermentation to acetate V";"Citrate cycle (TCA cycle)";"Neutrophil degranulation";"Reductive TCA cycle II";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"C5-Branched dibasic acid metabolism";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate VI";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)" lcl|NW_020311338.1_prot_XP_012263097.1_4552 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311995.1_prot_XP_012257189.1_22063 1 KEGG: 00970+6.1.1.9 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311995.1_prot_XP_020708375.1_22029 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" lcl|NW_020311309.1_prot_XP_012259166.1_2350 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" lcl|NW_020311374.1_prot_XP_020710887.1_6531 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311402.1_prot_XP_020711730.1_7703 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311391.1_prot_XP_012256735.1_7027 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311926.1_prot_XP_012250897.1_10617 2 Reactome: R-HSA-6783310;Reactome: R-HSA-6796648 "Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes" lcl|NW_020311423.1_prot_XP_012251560.1_8161 6 MetaCyc: PWY-622;MetaCyc: PWY-7900;KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085 "Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate" lcl|NW_020311959.1_prot_XP_020709522.1_13041 1 Reactome: R-HSA-6804756 "Regulation of TP53 Activity through Phosphorylation" lcl|NW_020311981.1_prot_XP_012257534.1_19041 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311314.1_prot_XP_020706757.1_3069 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311992.1_prot_XP_012266429.1_21224 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311966.1_prot_XP_012256882.1_15173 1 Reactome: R-HSA-112308 "Presynaptic depolarization and calcium channel opening" lcl|NW_020311401.1_prot_XP_012255057.1_7638 16 Reactome: R-HSA-2559580;Reactome: R-HSA-8948700;Reactome: R-HSA-8986944;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-9029569;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-8934593;Reactome: R-HSA-8943723;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459;Reactome: R-HSA-2559585 "Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Transcriptional Regulation by MECP2";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"Regulation of RUNX1 Expression and Activity";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Oncogene Induced Senescence" lcl|NW_020311957.1_prot_XP_012263325.1_12820 2 KEGG: 00260+2.3.1.29;Reactome: R-HSA-8849175 "Glycine, serine and threonine metabolism";"Threonine catabolism" lcl|NW_020311432.1_prot_XP_012268914.1_8344 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311388.1_prot_XP_020710951.1_6994 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311315.1_prot_XP_012265201.1_3130 2 Reactome: R-HSA-425366;Reactome: R-HSA-1483191 "Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC" lcl|NW_020311365.1_prot_XP_012269340.1_5990 4 Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" lcl|NW_020311984.1_prot_XP_012254504.1_19951 1 Reactome: R-HSA-2467813 "Separation of Sister Chromatids" lcl|NW_020311975.1_prot_XP_012252840.1_17077 5 Reactome: R-HSA-1912408;Reactome: R-HSA-1912420;Reactome: R-HSA-1912399;Reactome: R-HSA-5083630;Reactome: R-HSA-350054 "Pre-NOTCH Transcription and Translation";"Pre-NOTCH Processing in Golgi";"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Defective LFNG causes SCDO3";"Notch-HLH transcription pathway" lcl|NW_020311377.1_prot_XP_020712177.1_6581 6 Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-4086398;Reactome: R-HSA-8951430;Reactome: R-HSA-4411364 "Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"Ca2+ pathway";"RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters" lcl|NW_020311985.1_prot_XP_020707351.1_20294 9 MetaCyc: PWY-7117;MetaCyc: PWY-241;MetaCyc: PWY-7115;Reactome: R-HSA-1475029;MetaCyc: PWY-5744;KEGG: 00910+4.2.1.1;MetaCyc: PWY-6142;MetaCyc: PWY-5789;MetaCyc: PWY-5743 "C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Reversible hydration of carbon dioxide";"Glyoxylate assimilation";"Nitrogen metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"3-hydroxypropanoate cycle" lcl|NW_020311971.1_prot_XP_012260865.1_15890 3 Reactome: R-HSA-110320;Reactome: R-HSA-5656169;Reactome: R-HSA-5685942 "Translesion Synthesis by POLH";"Termination of translesion DNA synthesis";"HDR through Homologous Recombination (HRR)" lcl|NW_020311462.1_prot_XP_020706780.1_9213 4 Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-983712 "Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Ion channel transport" lcl|NW_020311962.1_prot_XP_012252003.1_13706 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311973.1_prot_XP_012258663.1_16580 7 Reactome: R-HSA-9010553;Reactome: R-HSA-5173105;Reactome: R-HSA-5083628;Reactome: R-HSA-5083633;Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-5083629 "Regulation of expression of SLITs and ROBOs";"O-linked glycosylation";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2" lcl|NW_020311971.1_prot_XP_012260854.1_15973 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311994.1_prot_XP_025603019.1_21510 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311994.1_prot_XP_020711908.1_21745 5 MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083 "NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation" lcl|NW_020311971.1_prot_XP_012260811.1_15855 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311985.1_prot_XP_012265295.1_20188 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311966.1_prot_XP_012256820.1_15181 22 Reactome: R-HSA-195253;Reactome: R-HSA-5467348;Reactome: R-HSA-5358747;Reactome: R-HSA-389513;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-196299;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-5675221;Reactome: R-HSA-68877;Reactome: R-HSA-5358749;Reactome: R-HSA-5339716;Reactome: R-HSA-5467340;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-5358752;Reactome: R-HSA-6811558;Reactome: R-HSA-5673000;Reactome: R-HSA-432142;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337 "Degradation of beta-catenin by the destruction complex";"Truncations of AMER1 destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"CTLA4 inhibitory signaling";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Beta-catenin phosphorylation cascade";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Negative regulation of MAPK pathway";"Mitotic Prometaphase";"S37 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"T41 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RAF activation";"Platelet sensitization by LDL";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding" lcl|NW_020311436.1_prot_XP_020708772.1_8770 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311977.1_prot_XP_012263707.1_17646 1 Reactome: R-HSA-427652 "Sodium-coupled phosphate cotransporters" lcl|NW_020311432.1_prot_XP_012268720.1_8451 4 Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556 "Transferrin endocytosis and recycling";"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes" lcl|NW_020311995.1_prot_XP_012256709.1_21913 3 KEGG: 00010+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00052+5.1.3.3 "Glycolysis / Gluconeogenesis";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism" lcl|NW_020311955.1_prot_XP_020711158.1_12461 5 Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379;Reactome: R-HSA-9615710;Reactome: R-HSA-174490 "Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events";"Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins" lcl|NW_020311987.1_prot_XP_020710418.1_20392 9 MetaCyc: PWY-7385;KEGG: 00564+1.1.1.8;MetaCyc: PWY-5667;MetaCyc: PWY-6118;Reactome: R-HSA-1483166;MetaCyc: PWY-7902;MetaCyc: PWY-7411;MetaCyc: PWY-5981;KEGG: 00564+1.1.1.94 "1,3-propanediol biosynthesis (engineered)";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Glycerol-3-phosphate shuttle";"Synthesis of PA";"Glucosylglycerol biosynthesis";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism" lcl|NW_020311972.1_prot_XP_020710964.1_16287 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311327.1_prot_XP_020710433.1_3860 13 MetaCyc: PWY-7822;Reactome: R-HSA-2024101;Reactome: R-HSA-2022857;MetaCyc: PWY-6902;Reactome: R-HSA-2160916;MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-1660662;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00520+3.2.1.52 "Chitin degradation III (Serratia)";"CS/DS degradation";"Keratan sulfate degradation";"Chitin degradation II (Vibrio)";"Hyaluronan uptake and degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Various types of N-glycan biosynthesis";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311934.1_prot_XP_020707808.1_10855 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311978.1_prot_XP_012258044.1_18286 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311393.1_prot_XP_012265719.1_7113 5 Reactome: R-HSA-936440;Reactome: R-HSA-9013973;Reactome: R-HSA-933541;Reactome: R-HSA-936964;Reactome: R-HSA-918233 "Negative regulators of DDX58/IFIH1 signaling";"TICAM1-dependent activation of IRF3/IRF7";"TRAF6 mediated IRF7 activation";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF3-dependent IRF activation pathway" lcl|NW_020311369.1_prot_XP_012264136.1_6234 5 MetaCyc: PWY-6168;KEGG: 00740+2.7.1.26;MetaCyc: PWY-5523;Reactome: R-HSA-196843;MetaCyc: PWY-7863 "Flavin biosynthesis III (fungi)";"Riboflavin metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Vitamin B2 (riboflavin) metabolism";"Roseoflavin biosynthesis" lcl|NW_020311977.1_prot_XP_012263913.1_17722 5 Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-9639288 "Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Amino acids regulate mTORC1" lcl|NW_020311948.1_prot_XP_012253635.1_11988 2 Reactome: R-HSA-1268020;Reactome: R-HSA-71403 "Mitochondrial protein import";"Citric acid cycle (TCA cycle)" lcl|NW_020311417.1_prot_XP_025602025.1_7952 3 Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095 "COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins" lcl|NW_020311961.1_prot_XP_012262724.1_13460 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311976.1_prot_XP_012253505.1_17295 14 Reactome: R-HSA-2173788;Reactome: R-HSA-68877;Reactome: R-HSA-9634638;Reactome: R-HSA-450520;Reactome: R-HSA-9648025;Reactome: R-HSA-165054;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-5687128;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-3769402;Reactome: R-HSA-69273;Reactome: R-HSA-2467813 "Downregulation of TGF-beta receptor signaling";"Mitotic Prometaphase";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"HuR (ELAVL1) binds and stabilizes mRNA";"EML4 and NUDC in mitotic spindle formation";"Rev-mediated nuclear export of HIV RNA";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"MAPK6/MAPK4 signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Deactivation of the beta-catenin transactivating complex";"Cyclin A/B1/B2 associated events during G2/M transition";"Separation of Sister Chromatids" lcl|NW_020311925.1_prot_XP_012252601.1_10534 12 Reactome: R-HSA-1251985;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-977225;Reactome: R-HSA-9017802;Reactome: R-HSA-2894862;Reactome: R-HSA-205043;Reactome: R-HSA-9013700;Reactome: R-HSA-193692;Reactome: R-HSA-2644606;Reactome: R-HSA-3928665 "Nuclear signaling by ERBB4";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Amyloid fiber formation";"Noncanonical activation of NOTCH3";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NRIF signals cell death from the nucleus";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Regulated proteolysis of p75NTR";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"EPH-ephrin mediated repulsion of cells" lcl|NW_020311971.1_prot_XP_025602672.1_15842 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311988.1_prot_XP_012261183.1_20717 1 Reactome: R-HSA-2565942 "Regulation of PLK1 Activity at G2/M Transition" lcl|NW_020311432.1_prot_XP_012268599.1_8490 2 Reactome: R-HSA-2022377;Reactome: R-HSA-6798695 "Metabolism of Angiotensinogen to Angiotensins";"Neutrophil degranulation" lcl|NW_020311973.1_prot_XP_012258615.1_16603 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" lcl|NW_020311980.1_prot_XP_012255715.1_18923 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" lcl|NW_020311984.1_prot_XP_012254571.1_19993 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311966.1_prot_XP_020708134.1_14880 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311969.1_prot_XP_020710963.1_15557 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311397.1_prot_XP_012258200.1_7301 3 Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-936837 "Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Ion transport by P-type ATPases" lcl|NW_020311943.1_prot_XP_020707641.1_11564 7 Reactome: R-HSA-2467813;Reactome: R-HSA-606279;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"Deposition of new CENPA-containing nucleosomes at the centromere";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins" lcl|NW_020311346.1_prot_XP_012268467.1_5033 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311513.1_prot_XP_012266090.1_9878 2 Reactome: R-HSA-69273;Reactome: R-HSA-8862803 "Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" lcl|NW_020311992.1_prot_XP_012266279.1_21089 17 KEGG: 05163+2.7.11.1;Reactome: R-HSA-5693607;Reactome: R-HSA-8953750;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6796648;Reactome: R-HSA-1433557;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05165+2.7.11.1;Reactome: R-HSA-69601;KEGG: 04151+2.7.11.1;Reactome: R-HSA-69473;Reactome: R-HSA-75035;Reactome: R-HSA-5693616;KEGG: 04926+2.7.11.1;Reactome: R-HSA-176187;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Processing of DNA double-strand break ends";"Transcriptional Regulation by E2F6";"Thermogenesis";"TP53 Regulates Transcription of DNA Repair Genes";"Signaling by SCF-KIT";"mTOR signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Human papillomavirus infection";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"PI3K-Akt signaling pathway";"G2/M DNA damage checkpoint";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Presynaptic phase of homologous DNA pairing and strand exchange";"Relaxin signaling pathway";"Activation of ATR in response to replication stress";"Human immunodeficiency virus 1 infection" lcl|NW_020311969.1_prot_XP_020710968.1_15564 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection" lcl|NW_020311973.1_prot_XP_020708836.1_16401 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311980.1_prot_XP_020709792.1_18852 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311994.1_prot_XP_020711903.1_21738 5 MetaCyc: PWY-7269;Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;MetaCyc: PWY-5083 "NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation" lcl|NW_020311300.1_prot_XP_012253160.1_1525 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311365.1_prot_XP_012269477.1_6034 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311377.1_prot_XP_020709526.1_6592 2 Reactome: R-HSA-168276;Reactome: R-HSA-1169408 "NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism" lcl|NW_020311967.1_prot_XP_012254332.1_15340 2 Reactome: R-HSA-176187;Reactome: R-HSA-68962 "Activation of ATR in response to replication stress";"Activation of the pre-replicative complex" lcl|NW_020311953.1_prot_XP_012260513.1_12247 5 Reactome: R-HSA-8856828;Reactome: R-HSA-432722;Reactome: R-HSA-6798695;Reactome: R-HSA-8856825;Reactome: R-HSA-6811440 "Clathrin-mediated endocytosis";"Golgi Associated Vesicle Biogenesis";"Neutrophil degranulation";"Cargo recognition for clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311984.1_prot_XP_020707591.1_20056 2 Reactome: R-HSA-418594;Reactome: R-HSA-6814122 "G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" lcl|NW_020311349.1_prot_XP_012251171.1_5230 7 Reactome: R-HSA-5628897;KEGG: 00471+3.5.1.2;Reactome: R-HSA-210500;KEGG: 00250+3.5.1.2;MetaCyc: PWY-5921;KEGG: 00220+3.5.1.2;Reactome: R-HSA-8964539 "TP53 Regulates Metabolic Genes";"D-Glutamine and D-glutamate metabolism";"Glutamate Neurotransmitter Release Cycle";"Alanine, aspartate and glutamate metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Arginine biosynthesis";"Glutamate and glutamine metabolism" lcl|NW_020311316.1_prot_XP_012269019.1_3163 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" lcl|NW_020311980.1_prot_XP_020709791.1_18851 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311978.1_prot_XP_020708615.1_18279 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311979.1_prot_XP_020709231.1_18542 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311955.1_prot_XP_020711146.1_12384 10 MetaCyc: PWY-6397;MetaCyc: PWY-3821;Reactome: R-HSA-70370;MetaCyc: PWY-7328;Reactome: R-HSA-5609977;MetaCyc: PWY-6317;MetaCyc: PWY-6527;KEGG: 00520+5.1.3.2;MetaCyc: PWY-7344;KEGG: 00052+5.1.3.2 "Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose detoxification";"Galactose catabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"UDP-alpha-D-galactose biosynthesis";"Galactose metabolism" lcl|NW_020311974.1_prot_XP_012260020.1_16660 3 MetaCyc: PWY-6100;Reactome: R-HSA-71262;KEGG: 00310+1.14.11.8 "L-carnitine biosynthesis";"Carnitine synthesis";"Lysine degradation" lcl|NW_020311472.1_prot_XP_012269220.1_9324 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311983.1_prot_XP_012255665.1_19692 1 KEGG: 00480+3.4.11.1 "Glutathione metabolism" lcl|NW_020311448.1_prot_XP_012252691.1_9001 1 Reactome: R-HSA-977347 "Serine biosynthesis" lcl|NW_020311476.1_prot_XP_012254091.1_9418 5 Reactome: R-HSA-5334118;Reactome: R-HSA-4655427;Reactome: R-HSA-212300;KEGG: 00270+2.1.1.37;Reactome: R-HSA-427413 "DNA methylation";"SUMOylation of DNA methylation proteins";"PRC2 methylates histones and DNA";"Cysteine and methionine metabolism";"NoRC negatively regulates rRNA expression" lcl|NW_020311917.1_prot_XP_012250989.1_10252 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311967.1_prot_XP_012254292.1_15278 5 Reactome: R-HSA-3270619;Reactome: R-HSA-1834949;Reactome: R-HSA-5693571;Reactome: R-HSA-164843;Reactome: R-HSA-6798695 "IRF3-mediated induction of type I IFN";"Cytosolic sensors of pathogen-associated DNA";"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation";"Neutrophil degranulation" lcl|NW_020311976.1_prot_XP_012257683.1_17384 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311325.1_prot_XP_012266956.1_3629 1 Reactome: R-HSA-442660 "Na+/Cl- dependent neurotransmitter transporters" lcl|NW_020311957.1_prot_XP_012263469.1_12837 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" lcl|NW_020311373.1_prot_XP_012262988.1_6402 3 KEGG: 00600+3.1.4.12;MetaCyc: PWY-7277;Reactome: R-HSA-1660662 "Sphingolipid metabolism";"Sphingolipid biosynthesis (mammals)";"Glycosphingolipid metabolism" lcl|NW_020311992.1_prot_XP_012266331.1_21211 2 Reactome: R-HSA-6798695;Reactome: R-HSA-983168 "Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311966.1_prot_XP_020708275.1_15125 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311971.1_prot_XP_012260923.1_15960 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311956.1_prot_XP_012251349.1_12635 2 Reactome: R-HSA-983168;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation" lcl|NW_020311984.1_prot_XP_012267661.1_20144 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311970.1_prot_XP_012267402.1_15776 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311966.1_prot_XP_020708126.1_14829 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311401.1_prot_XP_012254928.1_7582 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311397.1_prot_XP_020707298.1_7351 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311513.1_prot_XP_020711414.1_9685 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311304.1_prot_XP_012259567.1_1760 4 MetaCyc: PWY-5188;KEGG: 00860+4.2.1.75;Reactome: R-HSA-189451;MetaCyc: PWY-5189 "Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)" lcl|NW_020311973.1_prot_XP_012258667.1_16584 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" lcl|NW_020311401.1_prot_XP_012254939.1_7684 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" lcl|NW_020311315.1_prot_XP_020711109.1_3111 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311393.1_prot_XP_012265771.1_7208 5 Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-75035 "Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" lcl|NW_020311450.1_prot_XP_012260287.1_9049 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311979.1_prot_XP_012259735.1_18516 1 Reactome: R-HSA-446199 "Synthesis of Dolichyl-phosphate" lcl|NW_020311957.1_prot_XP_012263337.1_12783 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311325.1_prot_XP_012251491.1_3688 3 KEGG: 00790+6.3.2.17;Reactome: R-HSA-196757;MetaCyc: PWY-2161 "Folate biosynthesis";"Metabolism of folate and pterines";"Folate polyglutamylation" lcl|NW_020311988.1_prot_XP_012260312.1_20575 2 Reactome: R-HSA-204005;Reactome: R-HSA-5694530 "COPII-mediated vesicle transport";"Cargo concentration in the ER" lcl|NW_020311982.1_prot_XP_012264629.1_19389 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311292.1_prot_XP_020706875.1_513 10 MetaCyc: PWY-6369;MetaCyc: PWY-6361;MetaCyc: PWY-6372;MetaCyc: PWY-6362;KEGG: 00562+2.7.1.158;Reactome: R-HSA-1855191;KEGG: 04070+2.7.1.158;MetaCyc: PWY-6554;MetaCyc: PWY-4661;Reactome: R-HSA-1855167 "Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol phosphate metabolism";"Synthesis of IPs in the nucleus";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Synthesis of pyrophosphates in the cytosol" lcl|NW_020311985.1_prot_XP_012265297.1_20190 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311331.1_prot_XP_012264309.1_4078 5 Reactome: R-HSA-111457;Reactome: R-HSA-111464;Reactome: R-HSA-9627069;Reactome: R-HSA-111463;Reactome: R-HSA-111469 "Release of apoptotic factors from the mitochondria";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Regulation of the apoptosome activity";"SMAC (DIABLO) binds to IAPs";"SMAC, XIAP-regulated apoptotic response" lcl|NW_020311994.1_prot_XP_025603024.1_21515 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311475.1_prot_XP_012253317.1_9395 16 Reactome: R-HSA-1660499;Reactome: R-HSA-1433557;Reactome: R-HSA-1257604;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558;Reactome: R-HSA-389357;Reactome: R-HSA-416476;Reactome: R-HSA-512988;Reactome: R-HSA-912631;Reactome: R-HSA-114604;Reactome: R-HSA-912526;Reactome: R-HSA-194840;Reactome: R-HSA-8853659;Reactome: R-HSA-9009391;Reactome: R-HSA-388841;Reactome: R-HSA-1266695 "Synthesis of PIPs at the plasma membrane";"Signaling by SCF-KIT";"PIP3 activates AKT signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"CD28 dependent PI3K/Akt signaling";"G alpha (q) signalling events";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of signaling by CBL";"GPVI-mediated activation cascade";"Interleukin receptor SHC signaling";"Rho GTPase cycle";"RET signaling";"Extra-nuclear estrogen signaling";"Costimulation by the CD28 family";"Interleukin-7 signaling" lcl|NW_020311302.1_prot_XP_020710872.1_1672 3 Reactome: R-HSA-196783;MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33 "Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis" lcl|NW_020311969.1_prot_XP_020710966.1_15563 7 KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311359.1_prot_XP_012252100.1_5709 11 Reactome: R-HSA-110314;Reactome: R-HSA-68952;Reactome: R-HSA-5696397;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801;Reactome: R-HSA-68962;Reactome: R-HSA-5696400;Reactome: R-HSA-174430;Reactome: R-HSA-5685942 "Recognition of DNA damage by PCNA-containing replication complex";"DNA replication initiation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"Activation of the pre-replicative complex";"Dual Incision in GG-NER";"Telomere C-strand synthesis initiation";"HDR through Homologous Recombination (HRR)" lcl|NW_020311988.1_prot_XP_012268415.1_20639 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" lcl|NW_020311965.1_prot_XP_012259992.1_14214 4 KEGG: 00970+2.9.1.2;KEGG: 00450+2.9.1.2;MetaCyc: PWY-6281;Reactome: R-HSA-2408557 "Aminoacyl-tRNA biosynthesis";"Selenocompound metabolism";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocysteine synthesis" lcl|NW_020311432.1_prot_XP_020712311.1_8404 2 Reactome: R-HSA-2408508;Reactome: R-HSA-389661 "Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Glyoxylate metabolism and glycine degradation" lcl|NW_020311983.1_prot_XP_020711782.1_19450 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection" lcl|NW_020311441.1_prot_XP_020706512.1_8888 3 Reactome: R-HSA-189451;KEGG: 00860+1.3.3.4;MetaCyc: PWY-7159 "Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)" lcl|NW_020311982.1_prot_XP_020710900.1_19377 2 Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28 "Digestion of dietary carbohydrate";"Starch and sucrose metabolism" lcl|NW_020311977.1_prot_XP_012263719.1_17669 5 Reactome: R-HSA-159231;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163 "Transport of Mature mRNA Derived from an Intronless Transcript";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway" lcl|NW_020311337.1_prot_XP_012251780.1_4474 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311959.1_prot_XP_020710134.1_13104 1 Reactome: R-HSA-196108 "Pregnenolone biosynthesis" lcl|NW_020311980.1_prot_XP_012255727.1_18896 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" lcl|NW_020311372.1_prot_XP_025601912.1_6327 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" lcl|NW_020311961.1_prot_XP_012262731.1_13511 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311970.1_prot_XP_012269095.1_15615 4 Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394 "Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER" lcl|NW_020311975.1_prot_XP_025602710.1_16947 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311980.1_prot_XP_025602827.1_18912 26 Reactome: R-HSA-8866907;Reactome: R-HSA-9013508;Reactome: R-HSA-9617629;Reactome: R-HSA-1989781;Reactome: R-HSA-3214847;Reactome: R-HSA-210744;Reactome: R-HSA-5621575;Reactome: R-HSA-8941856;Reactome: R-HSA-1368082;Reactome: R-HSA-201722;Reactome: R-HSA-1912408;Reactome: R-HSA-3134973;Reactome: R-HSA-9013695;Reactome: R-HSA-9018519;Reactome: R-HSA-933541;Reactome: R-HSA-3371568;Reactome: R-HSA-918233;Reactome: R-HSA-5617472;Reactome: R-HSA-2122947;Reactome: R-HSA-3899300;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-1234158;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-9614657 "Activation of the TFAP2 (AP-2) family of transcription factors";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"PPARA activates gene expression";"HATs acetylate histones";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"CD209 (DC-SIGN) signaling";"RUNX3 regulates NOTCH signaling";"RORA activates gene expression";"Formation of the beta-catenin:TCF transactivating complex";"Pre-NOTCH Transcription and Translation";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"NOTCH4 Intracellular Domain Regulates Transcription";"Estrogen-dependent gene expression";"TRAF6 mediated IRF7 activation";"Attenuation phase";"TRAF3-dependent IRF activation pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"NOTCH1 Intracellular Domain Regulates Transcription";"SUMOylation of transcription cofactors";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"Regulation of gene expression by Hypoxia-inducible Factor";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"FOXO-mediated transcription of cell death genes" lcl|NW_020311343.1_prot_XP_012258268.1_4784 3 MetaCyc: PWY-7511;Reactome: R-HSA-6798695;Reactome: R-HSA-983168 "Protein ubiquitination";"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311419.1_prot_XP_012254069.1_8061 15 Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-113418;Reactome: R-HSA-167152;Reactome: R-HSA-167158;Reactome: R-HSA-9603505;Reactome: R-HSA-167242;Reactome: R-HSA-167238;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-167287 "Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the HIV-1 Early Elongation Complex";"NTRK3 as a dependence receptor";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery" lcl|NW_020311977.1_prot_XP_012264107.1_18004 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311975.1_prot_XP_020706963.1_17074 1 Reactome: R-HSA-212300 "PRC2 methylates histones and DNA" lcl|NW_020311417.1_prot_XP_025602029.1_7960 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" lcl|NW_020311966.1_prot_XP_020708098.1_15066 8 Reactome: R-HSA-5083629;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;Reactome: R-HSA-5173105;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109 "Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"O-linked glycosylation";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis" lcl|NW_020311313.1_prot_XP_012261778.1_2932 9 Reactome: R-HSA-9617324;Reactome: R-HSA-8849932;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-438066;Reactome: R-HSA-442982;Reactome: R-HSA-9620244;Reactome: R-HSA-3928662;Reactome: R-HSA-6794361 "Negative regulation of NMDA receptor-mediated neuronal transmission";"Synaptic adhesion-like molecules";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"Unblocking of NMDA receptors, glutamate binding and activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Long-term potentiation";"EPHB-mediated forward signaling";"Neurexins and neuroligins" lcl|NW_020311994.1_prot_XP_012262168.1_21848 3 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311425.1_prot_XP_012264987.1_8245 3 Reactome: R-HSA-416476;Reactome: R-HSA-375276;Reactome: R-HSA-881907 "G alpha (q) signalling events";"Peptide ligand-binding receptors";"Gastrin-CREB signalling pathway via PKC and MAPK" lcl|NW_020311965.1_prot_XP_012260062.1_14101 3 Reactome: R-HSA-70350;KEGG: 00051+2.7.1.3;Reactome: R-HSA-5657562 "Fructose catabolism";"Fructose and mannose metabolism";"Essential fructosuria" lcl|NW_020311982.1_prot_XP_012258409.1_19204 2 Reactome: R-HSA-73980;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation" lcl|NW_020311971.1_prot_XP_012269147.2_16151 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311356.1_prot_XP_020711757.1_5564 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" lcl|NW_020311981.1_prot_XP_012257607.1_19067 8 Reactome: R-HSA-69166;Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-174430;Reactome: R-HSA-174411;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-113501 "Removal of the Flap Intermediate";"Polymerase switching";"DNA replication initiation";"Telomere C-strand synthesis initiation";"Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Inhibition of replication initiation of damaged DNA by RB1/E2F1" lcl|NW_020311286.1_prot_XP_020708334.1_49 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311359.1_prot_XP_012252062.1_5716 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311944.1_prot_XP_012254210.1_11775 2 Reactome: R-HSA-6807004;Reactome: R-HSA-877312 "Negative regulation of MET activity";"Regulation of IFNG signaling" lcl|NW_020311391.1_prot_XP_025601969.1_7056 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311340.1_prot_XP_020706184.1_4686 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311941.1_prot_XP_012253169.1_11416 4 Reactome: R-HSA-6814122;Reactome: R-HSA-112043;Reactome: R-HSA-202040;Reactome: R-HSA-418594 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"PLC beta mediated events";"G-protein activation";"G alpha (i) signalling events" lcl|NW_020311401.1_prot_XP_012255234.1_7481 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" lcl|NW_020311991.1_prot_XP_012269742.1_20925 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311983.1_prot_XP_020707882.1_19794 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311978.1_prot_XP_012257724.1_18427 2 Reactome: R-HSA-3214847;Reactome: R-HSA-171319 "HATs acetylate histones";"Telomere Extension By Telomerase" lcl|NW_020311364.1_prot_XP_020708949.1_5924 6 Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311419.1_prot_XP_012254040.1_8091 13 MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7226;MetaCyc: PWY-7222;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7210;MetaCyc: PWY-7220;MetaCyc: PWY-6545;Reactome: R-HSA-499943;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7184;KEGG: 00230+1.17.4.1 "Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Interconversion of nucleotide di- and triphosphates";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism" lcl|NW_020311292.1_prot_XP_012262848.1_680 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-112308 "NCAM1 interactions";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening" lcl|NW_020311286.1_prot_XP_025603025.1_47 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311991.1_prot_XP_012269739.1_20917 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311979.1_prot_XP_020709233.1_18539 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311326.1_prot_XP_012261527.1_3725 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311289.1_prot_XP_012256141.1_399 2 Reactome: R-HSA-1268020;Reactome: R-HSA-1362409 "Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis" lcl|NW_020311526.1_prot_XP_020712511.1_9955 5 Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-176187 "Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress" lcl|NW_020311971.1_prot_XP_012263533.1_16082 12 Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids" lcl|NW_020311334.1_prot_XP_020711343.1_4349 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311324.1_prot_XP_020712522.1_3546 8 KEGG: 00240+6.3.5.5;MetaCyc: PWY-5686;KEGG: 00250+6.3.5.5;MetaCyc: PWY-7791;KEGG: 00240+3.5.2.3;MetaCyc: PWY-7790;MetaCyc: PWY-7400;MetaCyc: PWY-5154 "Pyrimidine metabolism";"UMP biosynthesis I";"Alanine, aspartate and glutamate metabolism";"UMP biosynthesis III";"Pyrimidine metabolism";"UMP biosynthesis II";"L-arginine biosynthesis IV (archaebacteria)";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)" lcl|NW_020311966.1_prot_XP_025602561.1_14419 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311966.1_prot_XP_012256423.1_15155 13 Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-72706 "Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311935.1_prot_XP_012266606.1_10917 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311983.1_prot_XP_020707881.1_19793 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311959.1_prot_XP_012259462.1_13183 56 Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5689880;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-5668541;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5610785;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9010553 "APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ub-specific processing proteases";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"TNFR2 non-canonical NF-kB pathway";"G2/M Checkpoints";"Regulation of RAS by GAPs";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311984.1_prot_XP_025602883.1_19818 8 KEGG: 00640+1.1.1.27;MetaCyc: PWY-5481;KEGG: 00010+1.1.1.27;KEGG: 00620+1.1.1.27;KEGG: 00270+1.1.1.27;MetaCyc: PWY-8086;Reactome: R-HSA-70268;MetaCyc: PWY-6901 "Propanoate metabolism";"Pyruvate fermentation to (S)-lactate";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Cysteine and methionine metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation" lcl|NW_020311925.1_prot_XP_012252622.1_10555 16 Reactome: R-HSA-176408;Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-176412;Reactome: R-HSA-174154;Reactome: R-HSA-2559582;Reactome: R-HSA-174084;Reactome: R-HSA-141430;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-176407;Reactome: R-HSA-8853884;Reactome: R-HSA-174048;Reactome: R-HSA-174184;Reactome: R-HSA-2467813 "Regulation of APC/C activators between G1/S and early anaphase";"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"Phosphorylation of the APC/C";"APC/C:Cdc20 mediated degradation of Securin";"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of Cyclin B";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids" lcl|NW_020311330.1_prot_XP_020712015.1_4035 6 Reactome: R-HSA-2173788;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-400253;Reactome: R-HSA-163560;KEGG: 04660+3.1.3.16 "Downregulation of TGF-beta receptor signaling";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Circadian Clock";"Triglyceride catabolism";"T cell receptor signaling pathway" lcl|NW_020311312.1_prot_XP_012266917.1_2591 5 Reactome: R-HSA-159236;Reactome: R-HSA-72165;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Minor Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway" lcl|NW_020311943.1_prot_XP_012255095.1_11741 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection" lcl|NW_020311382.1_prot_XP_020712033.1_6855 4 Reactome: R-HSA-6781823;Reactome: R-HSA-5696400;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135 "Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER" lcl|NW_020311323.1_prot_XP_020712045.1_3455 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311353.1_prot_XP_012255934.1_5432 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311971.1_prot_XP_012263567.1_16034 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311292.1_prot_XP_012252469.1_514 10 KEGG: 04070+2.7.1.158;MetaCyc: PWY-6554;Reactome: R-HSA-1855167;MetaCyc: PWY-4661;MetaCyc: PWY-6369;MetaCyc: PWY-6361;MetaCyc: PWY-6362;MetaCyc: PWY-6372;Reactome: R-HSA-1855191;KEGG: 00562+2.7.1.158 "Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of IPs in the nucleus";"Inositol phosphate metabolism" lcl|NW_020311971.1_prot_XP_012263596.1_16065 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311325.1_prot_XP_020706332.1_3685 3 Reactome: R-HSA-196757;MetaCyc: PWY-2161;KEGG: 00790+6.3.2.17 "Metabolism of folate and pterines";"Folate polyglutamylation";"Folate biosynthesis" lcl|NW_020311318.1_prot_XP_012253594.1_3283 7 Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-4615885 "RHO GTPases Activate Formins";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"SUMOylation of DNA replication proteins" lcl|NW_020311311.1_prot_XP_012250889.1_2448 10 MetaCyc: PWY-4061;KEGG: 00460+2.3.2.2;MetaCyc: PWY-7559;MetaCyc: PWY-4041;MetaCyc: PWY-6842;MetaCyc: PWY-8001;MetaCyc: PWY-7112;MetaCyc: PWY-5826;KEGG: 00430+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13 "Glutathione-mediated detoxification I";"Cyanoamino acid metabolism";"Glutathione degradation (DUG pathway";"Gamma-glutamyl cycle";"Glutathione-mediated detoxification II";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"4-hydroxy-2-nonenal detoxification";"Hypoglycin biosynthesis";"Taurine and hypotaurine metabolism";"Glutathione metabolism" lcl|NW_020311378.1_prot_XP_012260670.1_6624 5 Reactome: R-HSA-209543;Reactome: R-HSA-5205685;Reactome: R-HSA-205043;Reactome: R-HSA-9020702;Reactome: R-HSA-209560 "p75NTR recruits signalling complexes";"Pink/Parkin Mediated Mitophagy";"NRIF signals cell death from the nucleus";"Interleukin-1 signaling";"NF-kB is activated and signals survival" lcl|NW_020311977.1_prot_XP_012252239.1_17471 6 Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"RHO GTPases Activate Formins" lcl|NW_020311465.1_prot_XP_012268966.1_9271 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311966.1_prot_XP_020708247.1_14709 7 Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-73980 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination" lcl|NW_020311965.1_prot_XP_012259807.1_14200 11 MetaCyc: PWY-6992;MetaCyc: PWY-7456;MetaCyc: PWY-882;KEGG: 00051+5.3.1.8;Reactome: R-HSA-446205;MetaCyc: PWY-3881;MetaCyc: PWY-3861;KEGG: 00520+5.3.1.8;MetaCyc: PWY-5659;MetaCyc: PWY-7586;Reactome: R-HSA-4043916 "1,5-anhydrofructose degradation";"Beta-(1,4)-mannan degradation";"L-ascorbate biosynthesis I (L-galactose pathway)";"Fructose and mannose metabolism";"Synthesis of GDP-mannose";"Mannitol biosynthesis";"Mannitol degradation II";"Amino sugar and nucleotide sugar metabolism";"GDP-mannose biosynthesis";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Defective MPI causes MPI-CDG (CDG-1b)" lcl|NW_020311397.1_prot_XP_012258193.1_7295 3 Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311974.1_prot_XP_012259850.1_16705 5 Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977 "ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling" lcl|NW_020311937.1_prot_XP_012252654.1_11016 1 Reactome: R-HSA-1483191 "Synthesis of PC" lcl|NW_020311969.1_prot_XP_020710962.1_15556 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311966.1_prot_XP_012251730.1_14584 5 MetaCyc: PWY-6853;Reactome: R-HSA-70688;KEGG: 00330+1.2.1.88;Reactome: R-HSA-389661;KEGG: 00250+1.2.1.88 "Ethylene biosynthesis II (microbes)";"Proline catabolism";"Arginine and proline metabolism";"Glyoxylate metabolism and glycine degradation";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311344.1_prot_XP_012250635.1_4875 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" lcl|NW_020311304.1_prot_XP_012259575.1_1761 4 MetaCyc: PWY-5189;Reactome: R-HSA-189451;KEGG: 00860+4.2.1.75;MetaCyc: PWY-5188 "Tetrapyrrole biosynthesis II (from glycine)";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)" lcl|NW_020311971.1_prot_XP_012260825.1_15841 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311985.1_prot_XP_012265191.1_20248 42 Reactome: R-HSA-5625886;Reactome: R-HSA-5693565;Reactome: R-HSA-5617472;Reactome: R-HSA-8936459;Reactome: R-HSA-977225;Reactome: R-HSA-5578749;Reactome: R-HSA-3214842;Reactome: R-HSA-5250924;Reactome: R-HSA-2299718;Reactome: R-HSA-5693607;Reactome: R-HSA-2559586;Reactome: R-HSA-606279;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-201722;Reactome: R-HSA-5334118;Reactome: R-HSA-73772;Reactome: R-HSA-110329;Reactome: R-HSA-2559580;Reactome: R-HSA-3214815;Reactome: R-HSA-9610379;Reactome: R-HSA-212300;Reactome: R-HSA-73728;Reactome: R-HSA-1221632;Reactome: R-HSA-4551638;Reactome: R-HSA-5693571;Reactome: R-HSA-427413;Reactome: R-HSA-912446;Reactome: R-HSA-3214841;Reactome: R-HSA-9616222;Reactome: R-HSA-9609690;Reactome: R-HSA-427389;Reactome: R-HSA-110330;Reactome: R-HSA-3214858;Reactome: R-HSA-110331;Reactome: R-HSA-110328;Reactome: R-HSA-171306;Reactome: R-HSA-69473;Reactome: R-HSA-8939236;Reactome: R-HSA-2559582;Reactome: R-HSA-9018519;Reactome: R-HSA-427359 "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Amyloid fiber formation";"Transcriptional regulation by small RNAs";"HDMs demethylate histones";"B-WICH complex positively regulates rRNA expression";"Condensation of Prophase Chromosomes";"Processing of DNA double-strand break ends";"DNA Damage/Telomere Stress Induced Senescence";"Deposition of new CENPA-containing nucleosomes at the centromere";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"Formation of the beta-catenin:TCF transactivating complex";"DNA methylation";"RNA Polymerase I Promoter Escape";"Cleavage of the damaged pyrimidine";"Oxidative Stress Induced Senescence";"HDACs deacetylate histones";"HCMV Late Events";"PRC2 methylates histones and DNA";"RNA Polymerase I Promoter Opening";"Meiotic synapsis";"SUMOylation of chromatin organization proteins";"Nonhomologous End-Joining (NHEJ)";"NoRC negatively regulates rRNA expression";"Meiotic recombination";"PKMTs methylate histone lysines";"Transcriptional regulation of granulopoiesis";"HCMV Early Events";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Recognition and association of DNA glycosylase with site containing an affected purine";"RMTs methylate histone arginines";"Cleavage of the damaged purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Packaging Of Telomere Ends";"G2/M DNA damage checkpoint";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Senescence-Associated Secretory Phenotype (SASP)";"Estrogen-dependent gene expression";"SIRT1 negatively regulates rRNA expression" lcl|NW_020311977.1_prot_XP_012252243.1_17466 5 Reactome: R-HSA-8964539;MetaCyc: PWY-6344;MetaCyc: PWY-3341;KEGG: 00330+1.5.1.2;MetaCyc: PWY-4981 "Glutamate and glutamine metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism";"L-proline biosynthesis II (from arginine)" lcl|NW_020311326.1_prot_XP_012261531.1_3733 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311433.1_prot_XP_012264020.1_8606 5 MetaCyc: PWY-8013;Reactome: R-HSA-446210;KEGG: 00520+2.6.1.16;KEGG: 00250+2.6.1.16;MetaCyc: PWY-6749 "UDP-N-acetyl-D-galactosamine biosynthesis III";"Synthesis of UDP-N-acetyl-glucosamine";"Amino sugar and nucleotide sugar metabolism";"Alanine, aspartate and glutamate metabolism";"CMP-legionaminate biosynthesis I" lcl|NW_020311973.1_prot_XP_012258571.1_16343 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311298.1_prot_XP_012250590.1_1219 3 KEGG: 00970+6.1.1.19;Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" lcl|NW_020311401.1_prot_XP_012255355.1_7650 4 Reactome: R-HSA-5689880;Reactome: R-HSA-201681;Reactome: R-HSA-418594;Reactome: R-HSA-4641257 "Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"G alpha (i) signalling events";"Degradation of AXIN" lcl|NW_020311959.1_prot_XP_012262391.1_13077 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" lcl|NW_020311978.1_prot_XP_020708554.1_18248 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311964.1_prot_XP_012261673.1_14016 4 KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803 "alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing" lcl|NW_020311356.1_prot_XP_012267076.1_5510 2 Reactome: R-HSA-1369007;Reactome: R-HSA-5683371 "Mitochondrial ABC transporters";"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)" lcl|NW_020311988.1_prot_XP_020709737.1_20706 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157 "MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions" lcl|NW_020311973.1_prot_XP_012258662.1_16579 7 Reactome: R-HSA-9010553;Reactome: R-HSA-5173105;Reactome: R-HSA-5083633;Reactome: R-HSA-5083628;Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-5083629 "Regulation of expression of SLITs and ROBOs";"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2" lcl|NW_020311418.1_prot_XP_012261045.1_7992 1 Reactome: R-HSA-5666185 "RHO GTPases Activate Rhotekin and Rhophilins" lcl|NW_020311349.1_prot_XP_012251119.1_5263 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311966.1_prot_XP_012256388.1_14940 2 Reactome: R-HSA-8854214;Reactome: R-HSA-977225 "TBC/RABGAPs";"Amyloid fiber formation" lcl|NW_020311992.1_prot_XP_012266431.1_21226 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311958.1_prot_XP_012255478.1_12980 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311975.1_prot_XP_012253751.1_17033 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311939.1_prot_XP_012251678.1_11067 2 MetaCyc: PWY-6854;Reactome: R-HSA-3299685 "Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species" lcl|NW_020311988.1_prot_XP_012261206.1_20665 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311343.1_prot_XP_025601792.1_4769 5 Reactome: R-HSA-3108214;Reactome: R-HSA-110357;Reactome: R-HSA-5221030;Reactome: R-HSA-110328;Reactome: R-HSA-110329 "SUMOylation of DNA damage response and repair proteins";"Displacement of DNA glycosylase by APEX1";"TET1,2,3 and TDG demethylate DNA";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged pyrimidine" lcl|NW_020311372.1_prot_XP_012268457.1_6388 4 Reactome: R-HSA-5661270;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30;KEGG: 00040+2.7.1.17 "Formation of xylulose-5-phosphate";"Glycerol degradation I";"Glycerolipid metabolism";"Pentose and glucuronate interconversions" lcl|NW_020311299.1_prot_XP_012263178.1_1475 2 KEGG: 00970+6.1.1.21;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" lcl|NW_020311985.1_prot_XP_012265292.1_20254 1 Reactome: R-HSA-1483148 "Synthesis of PG" lcl|NW_020311988.1_prot_XP_020706218.1_20622 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311983.1_prot_XP_012267226.1_19492 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" lcl|NW_020311983.1_prot_XP_012255542.1_19745 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311432.1_prot_XP_020712260.1_8505 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" lcl|NW_020311448.1_prot_XP_020706910.1_9016 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" lcl|NW_020311433.1_prot_XP_012264004.1_8612 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" lcl|NW_020311968.1_prot_XP_012267692.1_15382 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" lcl|NW_020311967.1_prot_XP_012254325.1_15276 7 Reactome: R-HSA-1538133;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-156711 "G0 and Early G1";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Polo-like kinase mediated events" lcl|NW_020311940.1_prot_XP_012265568.1_11188 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311973.1_prot_XP_025602696.1_16431 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311513.1_prot_XP_020711404.1_9773 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311983.1_prot_XP_012267143.1_19432 14 Reactome: R-HSA-167152;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-113418 "Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the Early Elongation Complex" lcl|NW_020311401.1_prot_XP_012255256.1_7630 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311513.1_prot_XP_012266218.1_9686 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311380.1_prot_XP_012268198.1_6745 16 Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-141430;Reactome: R-HSA-179409;Reactome: R-HSA-176408;Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-174048;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-8853884 "Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC-Cdc20 mediated degradation of Nek2A";"Regulation of APC/C activators between G1/S and early anaphase";"Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Cyclin B";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Transcriptional Regulation by VENTX" lcl|NW_020311386.1_prot_XP_012268137.1_6922 7 MetaCyc: PWY-6605;MetaCyc: PWY-7805;MetaCyc: PWY-7807;Reactome: R-HSA-6798695;KEGG: 00230+2.4.2.7;Reactome: R-HSA-74217;MetaCyc: PWY-6610 "Adenine and adenosine salvage II";"(aminomethyl)phosphonate degradation";"Glyphosate degradation III";"Neutrophil degranulation";"Purine metabolism";"Purine salvage";"Adenine salvage" lcl|NW_020311289.1_prot_XP_020707383.1_379 2 Reactome: R-HSA-6804758;Reactome: R-HSA-3214847 "Regulation of TP53 Activity through Acetylation";"HATs acetylate histones" lcl|NW_020311513.1_prot_XP_012266141.1_9749 2 KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10 "One carbon pool by folate";"Glycine, serine and threonine metabolism" lcl|NW_020311294.1_prot_XP_012264905.1_892 13 Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-72706 "Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311946.1_prot_XP_012268603.1_11896 2 Reactome: R-HSA-6787450;Reactome: R-HSA-6782315 "tRNA modification in the mitochondrion";"tRNA modification in the nucleus and cytosol" lcl|NW_020311365.1_prot_XP_012269442.1_6030 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311983.1_prot_XP_012255541.1_19643 2 Reactome: R-HSA-983231;Reactome: R-HSA-168138 "Factors involved in megakaryocyte development and platelet production";"Toll Like Receptor 9 (TLR9) Cascade" lcl|NW_020311918.1_prot_XP_012264974.1_10377 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311306.1_prot_XP_012264222.1_2095 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311984.1_prot_XP_020711915.1_20120 2 Reactome: R-HSA-71403;Reactome: R-HSA-611105 "Citric acid cycle (TCA cycle)";"Respiratory electron transport" lcl|NW_020311397.1_prot_XP_020707305.1_7346 3 KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109;MetaCyc: PWY-4261 "Glycerolipid metabolism";"Triglyceride biosynthesis";"Glycerol degradation I" lcl|NW_020311375.1_prot_XP_012256612.1_6539 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311292.1_prot_XP_012252536.1_674 2 Reactome: R-HSA-446193;KEGG: 00510+2.4.1.256 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis" lcl|NW_020311397.1_prot_XP_012258198.1_7300 3 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases" lcl|NW_020311981.1_prot_XP_012257493.1_19057 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311971.1_prot_XP_012260877.1_15944 3 Reactome: R-HSA-383280;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "Nuclear Receptor transcription pathway";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311401.1_prot_XP_012255085.1_7494 2 Reactome: R-HSA-8876725;Reactome: R-HSA-611105 "Protein methylation";"Respiratory electron transport" lcl|NW_020311973.1_prot_XP_020708930.1_16633 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311619.1_prot_XP_020709574.1_10076 2 Reactome: R-HSA-5663213;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation" lcl|NW_020311978.1_prot_XP_012257906.1_18294 12 Reactome: R-HSA-1912408;Reactome: R-HSA-2122947;Reactome: R-HSA-3214847;Reactome: R-HSA-9013508;Reactome: R-HSA-210744;Reactome: R-HSA-8941856;Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-5250924;Reactome: R-HSA-2894862;Reactome: R-HSA-73762;Reactome: R-HSA-9013695 "Pre-NOTCH Transcription and Translation";"NOTCH1 Intracellular Domain Regulates Transcription";"HATs acetylate histones";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"RUNX3 regulates NOTCH signaling";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"B-WICH complex positively regulates rRNA expression";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"RNA Polymerase I Transcription Initiation";"NOTCH4 Intracellular Domain Regulates Transcription" lcl|NW_020311971.1_prot_XP_020709644.1_15903 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" lcl|NW_020311312.1_prot_XP_012266810.1_2665 3 KEGG: 00510+2.4.1.144;Reactome: R-HSA-975574;MetaCyc: PWY-7426 "N-Glycan biosynthesis";"Reactions specific to the hybrid N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)" lcl|NW_020311292.1_prot_XP_020710260.1_683 4 Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-419037 "Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"NCAM1 interactions" lcl|NW_020311967.1_prot_XP_020707505.1_15336 4 Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-975956 "Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" lcl|NW_020311966.1_prot_XP_012256375.1_14955 7 Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311993.1_prot_XP_012262662.1_21342 27 Reactome: R-HSA-4085377;Reactome: R-HSA-4615885;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-1169408;Reactome: R-HSA-9609690;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-6784531;Reactome: R-HSA-4551638;Reactome: R-HSA-168271;Reactome: R-HSA-5619107;Reactome: R-HSA-3371453;Reactome: R-HSA-4570464;Reactome: R-HSA-3108214;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-159230;Reactome: R-HSA-168333;Reactome: R-HSA-3301854;Reactome: R-HSA-159227;Reactome: R-HSA-3232142;Reactome: R-HSA-180746 "SUMOylation of SUMOylation proteins";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"ISG15 antiviral mechanism";"HCMV Early Events";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"tRNA processing in the nucleus";"SUMOylation of chromatin organization proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of HSF1-mediated heat shock response";"SUMOylation of RNA binding proteins";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"Transport of the SLBP Dependant Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP independent Mature mRNA";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein" lcl|NW_020311979.1_prot_XP_012259697.1_18490 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" lcl|NW_020311447.1_prot_XP_020706804.1_8967 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311964.1_prot_XP_025602518.1_13873 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311940.1_prot_XP_025602371.1_11172 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311436.1_prot_XP_012258434.1_8787 1 Reactome: R-HSA-5689877 "Josephin domain DUBs" lcl|NW_020311958.1_prot_XP_025602451.1_12916 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311338.1_prot_XP_020710333.1_4531 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" lcl|NW_020311933.1_prot_XP_012252890.1_10778 10 MetaCyc: PWY-5030;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;MetaCyc: PWY-1722;Reactome: R-HSA-196757;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-7909;MetaCyc: PWY-5497;MetaCyc: PWY-6613;MetaCyc: PWY-2201 "L-histidine degradation III";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Metabolism of folate and pterines";"One carbon pool by folate";"Formaldehyde oxidation VII (THF pathway)";"Purine nucleobases degradation II (anaerobic)";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Folate transformations I" lcl|NW_020311513.1_prot_XP_020711469.1_9851 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311955.1_prot_XP_012265319.1_12367 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311330.1_prot_XP_012267968.2_4033 6 Reactome: R-HSA-2173788;KEGG: 04658+3.1.3.16;Reactome: R-HSA-163560;KEGG: 04660+3.1.3.16;Reactome: R-HSA-400253;KEGG: 05235+3.1.3.16 "Downregulation of TGF-beta receptor signaling";"Th1 and Th2 cell differentiation";"Triglyceride catabolism";"T cell receptor signaling pathway";"Circadian Clock";"PD-L1 expression and PD-1 checkpoint pathway in cancer" lcl|NW_020311398.1_prot_XP_020709481.1_7382 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311364.1_prot_XP_020708952.1_5927 6 Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "RHO GTPases Activate Formins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311286.1_prot_XP_012257264.1_112 9 Reactome: R-HSA-3656237;Reactome: R-HSA-2024096;Reactome: R-HSA-3560783;Reactome: R-HSA-1971475;Reactome: R-HSA-2022928;Reactome: R-HSA-4420332;Reactome: R-HSA-975634;Reactome: R-HSA-3656253;Reactome: R-HSA-3560801 "Defective EXT2 causes exostoses 2";"HS-GAG degradation";"Defective B4GALT7 causes EDS, progeroid type";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG biosynthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Retinoid metabolism and transport";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective B3GAT3 causes JDSSDHD" lcl|NW_020311500.1_prot_XP_012260032.1_9582 56 Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-349425;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-5668541;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-174178 "Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"G2/M Checkpoints";"Regulation of RAS by GAPs";"TNFR2 non-canonical NF-kB pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" lcl|NW_020311976.1_prot_XP_012253438.1_17221 2 Reactome: R-HSA-983168;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation" lcl|NW_020311318.1_prot_XP_012253591.1_3282 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311959.1_prot_XP_020709511.1_13034 2 Reactome: R-HSA-6807878;Reactome: R-HSA-445095 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins" lcl|NW_020311286.1_prot_XP_025601768.1_219 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311955.1_prot_XP_012265324.1_12484 6 KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807 "Galactose metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)" lcl|NW_020311965.1_prot_XP_012259826.1_14141 1 Reactome: R-HSA-5693568 "Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311993.1_prot_XP_020710389.1_21407 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" lcl|NW_020311325.1_prot_XP_025603101.1_3661 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311977.1_prot_XP_012264078.1_17758 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311375.1_prot_XP_012256582.1_6540 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311977.1_prot_XP_012253912.1_17589 16 Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-6791226 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311973.1_prot_XP_012258636.1_16484 12 MetaCyc: PWY-6708;MetaCyc: PWY-5855;MetaCyc: PWY-5873;MetaCyc: PWY-5857;MetaCyc: PWY-7230;MetaCyc: PWY-5871;MetaCyc: PWY-5872;Reactome: R-HSA-2142789;MetaCyc: PWY-5856;MetaCyc: PWY-5870;KEGG: 00130+1.14.99.60;MetaCyc: PWY-7233 "Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-6 bypass biosynthesis (eukaryotic)" lcl|NW_020311526.1_prot_XP_012269454.1_9948 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311338.1_prot_XP_025601765.1_4562 5 Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;Reactome: R-HSA-6798695;Reactome: R-HSA-164843;Reactome: R-HSA-3270619 "Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"Neutrophil degranulation";"2-LTR circle formation";"IRF3-mediated induction of type I IFN" lcl|NW_020311983.1_prot_XP_020711765.1_19501 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" lcl|NW_020311958.1_prot_XP_020708049.1_12984 13 Reactome: R-HSA-381676;Reactome: R-HSA-139853;Reactome: R-HSA-112043;Reactome: R-HSA-5218921;Reactome: R-HSA-983695;Reactome: R-HSA-4086398;Reactome: R-HSA-422356;Reactome: R-HSA-2871809;Reactome: R-HSA-5578775;Reactome: R-HSA-1489509;Reactome: R-HSA-114508;Reactome: R-HSA-5607763;Reactome: R-HSA-2029485 "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Elevation of cytosolic Ca2+ levels";"PLC beta mediated events";"VEGFR2 mediated cell proliferation";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Ca2+ pathway";"Regulation of insulin secretion";"FCERI mediated Ca+2 mobilization";"Ion homeostasis";"DAG and IP3 signaling";"Effects of PIP2 hydrolysis";"CLEC7A (Dectin-1) induces NFAT activation";"Role of phospholipids in phagocytosis" lcl|NW_020311993.1_prot_XP_012262754.1_21335 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311976.1_prot_XP_020707166.1_17211 3 Reactome: R-HSA-391160;Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2 "Signal regulatory protein family interactions";"VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway" lcl|NW_020311991.1_prot_XP_020706212.1_20928 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311974.1_prot_XP_012259891.1_16913 2 Reactome: R-HSA-5678895;Reactome: R-HSA-382556 "Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport" lcl|NW_020311320.1_prot_XP_012267557.1_3375 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" lcl|NW_020311973.1_prot_XP_012258676.1_16372 14 KEGG: 00062+2.3.1.199;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7601;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-8041 "Fatty acid elongation";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis" lcl|NW_020311971.1_prot_XP_020709605.1_15836 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311953.1_prot_XP_012260511.1_12245 6 Reactome: R-HSA-114508;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107 "Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism" lcl|NW_020311962.1_prot_XP_020706746.1_13766 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311323.1_prot_XP_025603092.1_3457 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" lcl|NW_020311962.1_prot_XP_012251900.1_13618 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311984.1_prot_XP_020711910.1_20111 8 Reactome: R-HSA-69166;Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-174430;Reactome: R-HSA-174411;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-113501 "Removal of the Flap Intermediate";"Polymerase switching";"DNA replication initiation";"Telomere C-strand synthesis initiation";"Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Inhibition of replication initiation of damaged DNA by RB1/E2F1" lcl|NW_020311347.1_prot_XP_012266180.1_5049 56 Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-174084;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323 "Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"G2/M Checkpoints";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling" lcl|NW_020311962.1_prot_XP_012252000.1_13703 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311315.1_prot_XP_020711118.1_3119 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311396.1_prot_XP_012269518.1_7263 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311419.1_prot_XP_020707395.1_8114 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311955.1_prot_XP_012265423.1_12528 179 Reactome: R-HSA-72764;Reactome: R-HSA-5696400;Reactome: R-HSA-1169091;Reactome: R-HSA-5675482;Reactome: R-HSA-174184;Reactome: R-HSA-1253288;Reactome: R-HSA-2408557;Reactome: R-HSA-5610785;Reactome: R-HSA-3134975;Reactome: R-HSA-2122948;Reactome: R-HSA-9014325;Reactome: R-HSA-174178;Reactome: R-HSA-977225;Reactome: R-HSA-156902;Reactome: R-HSA-4641258;Reactome: R-HSA-5685942;Reactome: R-HSA-187577;Reactome: R-HSA-5357956;Reactome: R-HSA-2979096;Reactome: R-HSA-110312;Reactome: R-HSA-209560;Reactome: R-HSA-8875360;Reactome: R-HSA-6783310;Reactome: R-HSA-901032;Reactome: R-HSA-2559585;Reactome: R-HSA-2173788;Reactome: R-HSA-5689880;Reactome: R-HSA-209543;Reactome: R-HSA-975957;Reactome: R-HSA-8948747;Reactome: R-HSA-936964;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-8863795;Reactome: R-HSA-5689901;Reactome: R-HSA-2565942;Reactome: R-HSA-5656121;Reactome: R-HSA-174154;Reactome: R-HSA-2559582;Reactome: R-HSA-5675221;Reactome: R-HSA-382556;Reactome: R-HSA-936440;Reactome: R-HSA-69231;Reactome: R-HSA-8854050;Reactome: R-HSA-6782210;Reactome: R-HSA-5654726;Reactome: R-HSA-349425;Reactome: R-HSA-9615710;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5654727;Reactome: R-HSA-2467813;Reactome: R-HSA-2894862;Reactome: R-HSA-5610780;Reactome: R-HSA-9645460;Reactome: R-HSA-2122947;Reactome: R-HSA-5358346;Reactome: R-HSA-162588;Reactome: R-HSA-5693565;Reactome: R-HSA-9010553;Reactome: R-HSA-450321;Reactome: R-HSA-69541;Reactome: R-HSA-9013973;Reactome: R-HSA-174084;Reactome: R-HSA-8856828;Reactome: R-HSA-8866654;Reactome: R-HSA-2559580;Reactome: R-HSA-917937;Reactome: R-HSA-9613829;Reactome: R-HSA-4641257;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-110314;Reactome: R-HSA-2644606;Reactome: R-HSA-8948751;Reactome: R-HSA-975144;Reactome: R-HSA-192823;Reactome: R-HSA-1236382;Reactome: R-HSA-450408;Reactome: R-HSA-2691232;Reactome: R-HSA-1295596;Reactome: R-HSA-5689877;Reactome: R-HSA-8939236;Reactome: R-HSA-445989;Reactome: R-HSA-8849469;Reactome: R-HSA-5607761;Reactome: R-HSA-2173796;Reactome: R-HSA-2173791;Reactome: R-HSA-975956;Reactome: R-HSA-180585;Reactome: R-HSA-3769402;Reactome: R-HSA-2871837;Reactome: R-HSA-3785653;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-1799339;Reactome: R-HSA-5696394;Reactome: R-HSA-6804756;Reactome: R-HSA-5696397;Reactome: R-HSA-5654732;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-937041;Reactome: R-HSA-9020702;Reactome: R-HSA-6781827;Reactome: R-HSA-450302;Reactome: R-HSA-5656169;Reactome: R-HSA-205043;Reactome: R-HSA-5658442;Reactome: R-HSA-179409;Reactome: R-HSA-9604323;Reactome: R-HSA-5205685;Reactome: R-HSA-2173795;Reactome: R-HSA-6781823;Reactome: R-HSA-1169408;Reactome: R-HSA-174048;Reactome: R-HSA-180534;Reactome: R-HSA-168638;Reactome: R-HSA-174113;Reactome: R-HSA-6804757;Reactome: R-HSA-5632684;Reactome: R-HSA-9033241;Reactome: R-HSA-8876493;Reactome: R-HSA-72706;Reactome: R-HSA-211733;Reactome: R-HSA-532668;Reactome: R-HSA-2672351;Reactome: R-HSA-4641263;Reactome: R-HSA-174490;Reactome: R-HSA-6807004;Reactome: R-HSA-937042;Reactome: R-HSA-6791226;Reactome: R-HSA-937072;Reactome: R-HSA-4608870;Reactome: R-HSA-168928;Reactome: R-HSA-5654733;Reactome: R-HSA-5693607;Reactome: R-HSA-9637628;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-917729;Reactome: R-HSA-5684264;Reactome: R-HSA-5607764;Reactome: R-HSA-5689896;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-6804760;Reactome: R-HSA-975110;Reactome: R-HSA-69481;Reactome: R-HSA-8866652;Reactome: R-HSA-912631;Reactome: R-HSA-5655862;Reactome: R-HSA-9633012;Reactome: R-HSA-8951664;Reactome: R-HSA-182971;Reactome: R-HSA-156827;Reactome: R-HSA-9646399;Reactome: R-HSA-202424;Reactome: R-HSA-5357905;Reactome: R-HSA-400253;Reactome: R-HSA-5689603;Reactome: R-HSA-110320;Reactome: R-HSA-9013507;Reactome: R-HSA-1358803;Reactome: R-HSA-937039;Reactome: R-HSA-3322077;Reactome: R-HSA-9636383;Reactome: R-HSA-68949;Reactome: R-HSA-72689;Reactome: R-HSA-201681;Reactome: R-HSA-975163;Reactome: R-HSA-8939902;Reactome: R-HSA-175474;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-168927;Reactome: R-HSA-8856825 "Eukaryotic Translation Termination";"Dual Incision in GG-NER";"Activation of NF-kappaB in B cells";"Regulation of necroptotic cell death";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Downregulation of ERBB4 signaling";"Selenocysteine synthesis";"GLI3 is processed to GLI3R by the proteasome";"Regulation of innate immune responses to cytosolic DNA";"Activated NOTCH1 Transmits Signal to the Nucleus";"TICAM1,TRAF6-dependent induction of TAK1 complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Amyloid fiber formation";"Peptide chain elongation";"Degradation of DVL";"HDR through Homologous Recombination (HRR)";"SCF(Skp2)-mediated degradation of p27/p21";"TNFR1-induced NFkappaB signaling pathway";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Translesion synthesis by REV1";"NF-kB is activated and signals survival";"InlB-mediated entry of Listeria monocytogenes into host cell";"Fanconi Anemia Pathway";"ER Quality Control Compartment (ERQC)";"Oncogene Induced Senescence";"Downregulation of TGF-beta receptor signaling";"Ub-specific processing proteases";"p75NTR recruits signalling complexes";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of PTEN localization";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Downregulation of ERBB2 signaling";"Metalloprotease DUBs";"Regulation of PLK1 Activity at G2/M Transition";"Translesion synthesis by POLI";"APC/C:Cdc20 mediated degradation of Securin";"Senescence-Associated Secretory Phenotype (SASP)";"Negative regulation of MAPK pathway";"ABC-family proteins mediated transport";"Negative regulators of DDX58/IFIH1 signaling";"Cyclin D associated events in G1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Negative regulation of FGFR1 signaling";"Autodegradation of the E3 ubiquitin ligase COP1";"Late endosomal microautophagy";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Negative regulation of FGFR2 signaling";"Separation of Sister Chromatids";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Degradation of GLI1 by the proteasome";"Alpha-protein kinase 1 signaling pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Hedgehog ligand biogenesis";"Budding and maturation of HIV virion";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of expression of SLITs and ROBOs";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Stabilization of p53";"TICAM1-dependent activation of IRF3/IRF7";"Autodegradation of Cdh1 by Cdh1:APC/C";"Clathrin-mediated endocytosis";"E3 ubiquitin ligases ubiquitinate target proteins";"Oxidative Stress Induced Senescence";"Iron uptake and transport";"Chaperone Mediated Autophagy";"Degradation of AXIN";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Recognition of DNA damage by PCNA-containing replication complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of PTEN stability and activity";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Viral mRNA Translation";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Spry regulation of FGF signaling";"Josephin domain DUBs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"Dectin-1 mediated noncanonical NF-kB signaling";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Vif-mediated degradation of APOBEC3G";"Deactivation of the beta-catenin transactivating complex";"FCERI mediated NF-kB activation";"Myoclonic epilepsy of Lafora";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"SRP-dependent cotranslational protein targeting to membrane";"DNA Damage Recognition in GG-NER";"Regulation of TP53 Activity through Phosphorylation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Negative regulation of FGFR3 signaling";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"IKK complex recruitment mediated by RIP1";"Interleukin-1 signaling";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"activated TAK1 mediates p38 MAPK activation";"Termination of translesion DNA synthesis";"NRIF signals cell death from the nucleus";"Regulation of RAS by GAPs";"APC-Cdc20 mediated degradation of Nek2A";"Negative regulation of NOTCH4 signaling";"Pink/Parkin Mediated Mitophagy";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Formation of TC-NER Pre-Incision Complex";"ISG15 antiviral mechanism";"APC/C:Cdc20 mediated degradation of Cyclin B";"Vpu mediated degradation of CD4";"NOD1/2 Signaling Pathway";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of TP53 Degradation";"Hedgehog 'on' state";"Peroxisomal protein import";"InlA-mediated entry of Listeria monocytogenes into host cells";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Stimuli-sensing channels";"Regulation of FZD by ubiquitination";"Membrane binding and targetting of GAG proteins";"Negative regulation of MET activity";"IRAK2 mediated activation of TAK1 complex";"Major pathway of rRNA processing in the nucleolus and cytosol";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Asymmetric localization of PCP proteins";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Negative regulation of FGFR4 signaling";"Processing of DNA double-strand break ends";"Modulation by Mtb of host immune system";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Endosomal Sorting Complex Required For Transport (ESCRT)";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"CLEC7A (Dectin-1) signaling";"Ovarian tumor domain proteases";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of TP53 Activity through Methylation";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"G2/M Checkpoints";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Regulation of signaling by CBL";"Translesion synthesis by POLK";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Neddylation";"EGFR downregulation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Aggrephagy";"Downstream TCR signaling";"Regulation of TNFR1 signaling";"Circadian Clock";"UCH proteinases";"Translesion Synthesis by POLH";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Downregulation of ERBB2:ERBB3 signaling";"IRAK1 recruits IKK complex";"Glycogen synthesis";"Prevention of phagosomal-lysosomal fusion";"Orc1 removal from chromatin";"Formation of a pool of free 40S subunits";"TCF dependent signaling in response to WNT";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"Regulation of RUNX2 expression and activity";"Assembly Of The HIV Virion";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"TICAM1, RIP1-mediated IKK complex recruitment";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311311.1_prot_XP_012250849.1_2574 2 Reactome: R-HSA-446193;Reactome: R-HSA-4570571 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective RFT1 causes RFT1-CDG (CDG-1n)" lcl|NW_020311513.1_prot_XP_012266092.1_9880 2 Reactome: R-HSA-69273;Reactome: R-HSA-8862803 "Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" lcl|NW_020311401.1_prot_XP_012255356.1_7651 4 Reactome: R-HSA-201681;Reactome: R-HSA-5689880;Reactome: R-HSA-4641257;Reactome: R-HSA-418594 "TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"Degradation of AXIN";"G alpha (i) signalling events" lcl|NW_020311940.1_prot_XP_012265565.1_11190 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311944.1_prot_XP_012254197.1_11771 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311462.1_prot_XP_012252267.1_9215 4 Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-983712 "Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Ion channel transport" lcl|NW_020311974.1_prot_XP_012259848.1_16701 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311995.1_prot_XP_020708159.1_22035 9 Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-73779 "Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311966.1_prot_XP_012253701.1_14509 4 MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855 "Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)" lcl|NW_020311975.1_prot_XP_012251273.1_16941 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311982.1_prot_XP_020708732.1_19253 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311334.1_prot_XP_025601756.1_4342 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311432.1_prot_XP_012268886.1_8492 6 Reactome: R-HSA-5099900;KEGG: 04070+2.7.11.13;Reactome: R-HSA-416993;Reactome: R-HSA-76005;Reactome: R-HSA-418597;Reactome: R-HSA-114516 "WNT5A-dependent internalization of FZD4";"Phosphatidylinositol signaling system";"Trafficking of GluR2-containing AMPA receptors";"Response to elevated platelet cytosolic Ca2+";"G alpha (z) signalling events";"Disinhibition of SNARE formation" lcl|NW_020311970.1_prot_XP_012267576.1_15792 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.4 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311339.1_prot_XP_012254182.1_4613 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311294.1_prot_XP_020711011.1_881 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" lcl|NW_020311942.1_prot_XP_012252457.1_11458 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" lcl|NW_020311984.1_prot_XP_020711943.1_20148 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311286.1_prot_XP_012256682.1_53 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311961.1_prot_XP_020710228.1_13519 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311401.1_prot_XP_012254830.1_7483 3 Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148 "Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311969.1_prot_XP_020710972.1_15566 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311985.1_prot_XP_012265173.1_20283 3 Reactome: R-HSA-1474151;Reactome: R-HSA-203615;KEGG: 00790+1.1.1.153 "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"eNOS activation";"Folate biosynthesis" lcl|NW_020311966.1_prot_XP_012256209.1_14746 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311980.1_prot_XP_020709789.1_18854 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311992.1_prot_XP_012266378.1_21049 2 Reactome: R-HSA-3108214;MetaCyc: PWY-7511 "SUMOylation of DNA damage response and repair proteins";"Protein ubiquitination" lcl|NW_020311935.1_prot_XP_012266613.1_10920 6 Reactome: R-HSA-111367;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-72165;Reactome: R-HSA-191859 "SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"mRNA Splicing - Minor Pathway";"snRNP Assembly" lcl|NW_020311980.1_prot_XP_012261329.1_18779 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311965.1_prot_XP_012259498.2_14366 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311401.1_prot_XP_012262404.1_7413 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311424.1_prot_XP_012255437.1_8238 7 KEGG: 00195+7.1.2.2;Reactome: R-HSA-2151201;Reactome: R-HSA-163210;Reactome: R-HSA-1268020;Reactome: R-HSA-8949613;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980 "Photosynthesis";"Transcriptional activation of mitochondrial biogenesis";"Formation of ATP by chemiosmotic coupling";"Mitochondrial protein import";"Cristae formation";"Oxidative phosphorylation";"ATP biosynthesis" lcl|NW_020311332.1_prot_XP_012256532.1_4193 14 KEGG: 00565+3.1.3.4;MetaCyc: PWY-7782;Reactome: R-HSA-1483191;MetaCyc: PWY-6453;MetaCyc: PWY-8051;Reactome: R-HSA-75109;MetaCyc: PWY-8052;KEGG: 00561+3.1.3.4;KEGG: 00564+3.1.3.4;Reactome: R-HSA-1483213;KEGG: 00600+3.1.3.4;Reactome: R-HSA-4419969;MetaCyc: PWY-8053;MetaCyc: PWY-8055 "Ether lipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PC";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Triglyceride biosynthesis";"2-arachidonoylglycerol biosynthesis";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Synthesis of PE";"Sphingolipid metabolism";"Depolymerisation of the Nuclear Lamina";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis" lcl|NW_020311382.1_prot_XP_012268032.1_6872 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311985.1_prot_XP_025602914.1_20205 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311964.1_prot_XP_025602516.1_13871 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311334.1_prot_XP_020711366.1_4383 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311393.1_prot_XP_020711320.1_7148 7 MetaCyc: PWY-7790;MetaCyc: PWY-5686;MetaCyc: PWY-7791;KEGG: 00240+3.5.2.3;MetaCyc: PWY-5698;MetaCyc: PWY-5697;KEGG: 00230+3.5.2.5 "UMP biosynthesis II";"UMP biosynthesis I";"UMP biosynthesis III";"Pyrimidine metabolism";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Allantoin degradation to ureidoglycolate I (urea producing)";"Purine metabolism" lcl|NW_020311966.1_prot_XP_012256808.1_15007 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311353.1_prot_XP_012255916.1_5439 1 Reactome: R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins" lcl|NW_020311973.1_prot_XP_012258707.1_16544 2 Reactome: R-HSA-3108214;Reactome: R-HSA-5685938 "SUMOylation of DNA damage response and repair proteins";"HDR through Single Strand Annealing (SSA)" lcl|NW_020311300.1_prot_XP_012253168.1_1531 1 Reactome: R-HSA-176974 "Unwinding of DNA" lcl|NW_020311346.1_prot_XP_012262945.1_4985 29 Reactome: R-HSA-5696400;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-6796648;Reactome: R-HSA-73863;Reactome: R-HSA-6781827;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-167161 "Dual Incision in GG-NER";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"mRNA Capping";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HIV Transcription Initiation" lcl|NW_020311955.1_prot_XP_020711186.1_12400 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311982.1_prot_XP_012258420.1_19197 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" lcl|NW_020311962.1_prot_XP_012252010.1_13744 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311325.1_prot_XP_012251296.1_3658 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311314.1_prot_XP_020706756.1_3082 4 MetaCyc: PWY-3722;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163;MetaCyc: PWY-7494 "Glycine betaine biosynthesis II (Gram-positive bacteria)";"Glycine, serine and threonine metabolism";"Choline catabolism";"Choline degradation IV" lcl|NW_020311321.1_prot_XP_012263252.2_3439 2 Reactome: R-HSA-2682334;Reactome: R-HSA-3928665 "EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells" lcl|NW_020311973.1_prot_XP_012258628.1_16477 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311974.1_prot_XP_020709388.1_16920 2 Reactome: R-HSA-416993;Reactome: R-HSA-202733 "Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall" lcl|NW_020311961.1_prot_XP_012262546.1_13234 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311957.1_prot_XP_012263343.1_12888 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" lcl|NW_020311994.1_prot_XP_012267537.1_21761 8 Reactome: R-HSA-1855183;MetaCyc: PWY-6664;MetaCyc: PWY-2301;MetaCyc: PWY-6372;KEGG: 00521+5.5.1.4;MetaCyc: PWY-6580;MetaCyc: PWY-4661;KEGG: 00562+5.5.1.4 "Synthesis of IP2, IP, and Ins in the cytosol";"Di-myo-inositol phosphate biosynthesis";"Myo-inositol biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Streptomycin biosynthesis";"Phosphatidylinositol biosynthesis I (bacteria)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Inositol phosphate metabolism" lcl|NW_020311961.1_prot_XP_012262526.1_13260 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311975.1_prot_XP_025602709.1_16972 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311982.1_prot_XP_012258406.1_19199 2 Reactome: R-HSA-749476;Reactome: R-HSA-73980 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination" lcl|NW_020311984.1_prot_XP_012267682.1_20155 18 KEGG: 00270+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00250+2.6.1.1;MetaCyc: PWY-6638;MetaCyc: PWY-7383;KEGG: 00360+2.6.1.1;MetaCyc: PWY-6642;KEGG: 00400+2.6.1.1;KEGG: 00710+2.6.1.1;MetaCyc: PWY-5913;MetaCyc: PWY-7115;MetaCyc: PWY-6643;KEGG: 00330+2.6.1.1;MetaCyc: PWY-7117 "Cysteine and methionine metabolism";"Arginine biosynthesis";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Novobiocin biosynthesis";"Tyrosine metabolism";"Isoquinoline alkaloid biosynthesis";"Alanine, aspartate and glutamate metabolism";"Sulfolactate degradation III";"Anaerobic energy metabolism (invertebrates, cytosol)";"Phenylalanine metabolism";"(R)-cysteate degradation";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Carbon fixation in photosynthetic organisms";"Partial TCA cycle (obligate autotrophs)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Coenzyme M biosynthesis II";"Arginine and proline metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type" lcl|NW_020311976.1_prot_XP_020708677.1_17361 3 Reactome: R-HSA-9603798;Reactome: R-HSA-9033241;Reactome: R-HSA-8866654 "Class I peroxisomal membrane protein import";"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins" lcl|NW_020311403.1_prot_XP_020708789.1_7728 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311979.1_prot_XP_020709212.1_18556 8 KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Activation of RAC1";"Thermogenesis";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311967.1_prot_XP_025602608.1_15251 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311433.1_prot_XP_012264048.1_8703 3 Reactome: R-HSA-1660662;KEGG: 00600+3.2.1.45;KEGG: 00511+3.2.1.45 "Glycosphingolipid metabolism";"Sphingolipid metabolism";"Other glycan degradation" lcl|NW_020311992.1_prot_XP_012266365.1_21150 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311462.1_prot_XP_012252269.1_9217 4 Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387 "Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling" lcl|NW_020311940.1_prot_XP_025602344.1_11189 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311975.1_prot_XP_012252674.1_17104 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311334.1_prot_XP_020711344.1_4348 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311953.1_prot_XP_012260514.1_12249 5 Reactome: R-HSA-432722;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-6811440;Reactome: R-HSA-6798695 "Golgi Associated Vesicle Biogenesis";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network";"Neutrophil degranulation" lcl|NW_020311401.1_prot_XP_012254904.1_7531 1 Reactome: R-HSA-1362409 "Mitochondrial iron-sulfur cluster biogenesis" lcl|NW_020311964.1_prot_XP_012261751.1_13984 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311972.1_prot_XP_012264758.1_16308 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311375.1_prot_XP_012256503.2_6559 1 Reactome: R-HSA-1296061 "HCN channels" lcl|NW_020311982.1_prot_XP_020708734.1_19255 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311992.1_prot_XP_012266285.1_21029 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311324.1_prot_XP_012269457.1_3541 2 Reactome: R-HSA-5218920;Reactome: R-HSA-418990 "VEGFR2 mediated vascular permeability";"Adherens junctions interactions" lcl|NW_020311372.1_prot_XP_012268390.1_6298 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311992.1_prot_XP_012266361.1_21146 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311934.1_prot_XP_020707810.1_10864 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311513.1_prot_XP_012266140.1_9751 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" lcl|NW_020311298.1_prot_XP_012269930.1_1259 6 Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450513 "mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" lcl|NW_020311943.1_prot_XP_020707663.1_11722 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311981.1_prot_XP_012257341.1_19108 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311925.1_prot_XP_012252597.1_10557 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" lcl|NW_020311296.1_prot_XP_012265135.1_1037 19 MetaCyc: PWY-7220;KEGG: 00230+2.7.4.6;KEGG: 00240+2.7.4.6;Reactome: R-HSA-380270;MetaCyc: PWY-7226;MetaCyc: PWY-7222;MetaCyc: PWY-7224;MetaCyc: PWY-7197;MetaCyc: PWY-7221;MetaCyc: PWY-6545;MetaCyc: PWY-7184;MetaCyc: PWY-7198;MetaCyc: PWY-7176;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7227;MetaCyc: PWY-7205;MetaCyc: PWY-7210;Reactome: R-HSA-380320;MetaCyc: PWY-7187 "Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Pyrimidine metabolism";"Recruitment of mitotic centrosome proteins and complexes";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotide phosphorylation";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"UTP and CTP de novo biosynthesis";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis";"CMP phosphorylation";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Recruitment of NuMA to mitotic centrosomes";"Pyrimidine deoxyribonucleotides de novo biosynthesis II" lcl|NW_020311979.1_prot_XP_012259615.1_18504 15 Reactome: R-HSA-9665233;Reactome: R-HSA-9665245;Reactome: R-HSA-1236382;Reactome: R-HSA-9665246;Reactome: R-HSA-9664565;Reactome: R-HSA-9652282;Reactome: R-HSA-9634285;Reactome: R-HSA-9665247;Reactome: R-HSA-9665251;Reactome: R-HSA-9665250;Reactome: R-HSA-9665249;Reactome: R-HSA-8863795;Reactome: R-HSA-1227986;Reactome: R-HSA-5637810;Reactome: R-HSA-9665244 "Resistance of ERBB2 KD mutants to trastuzumab";"Resistance of ERBB2 KD mutants to tesevatinib";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Resistance of ERBB2 KD mutants to neratinib";"Signaling by ERBB2 KD Mutants";"Drug-mediated inhibition of ERBB2 signaling";"Constitutive Signaling by Overexpressed ERBB2";"Resistance of ERBB2 KD mutants to osimertinib";"Resistance of ERBB2 KD mutants to lapatinib";"Resistance of ERBB2 KD mutants to AEE788";"Resistance of ERBB2 KD mutants to afatinib";"Downregulation of ERBB2 signaling";"Signaling by ERBB2";"Constitutive Signaling by EGFRvIII";"Resistance of ERBB2 KD mutants to sapitinib" lcl|NW_020311966.1_prot_XP_012256931.1_14914 1 Reactome: R-HSA-5389840 "Mitochondrial translation elongation" lcl|NW_020311419.1_prot_XP_012254044.1_8095 13 KEGG: 00230+1.17.4.1;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7184;Reactome: R-HSA-499943;MetaCyc: PWY-7220;MetaCyc: PWY-6545;MetaCyc: PWY-7222;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7210;MetaCyc: PWY-7227;MetaCyc: PWY-7226;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1 "Purine metabolism";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism" lcl|NW_020311299.1_prot_XP_012263158.1_1433 1 Reactome: R-HSA-427359 "SIRT1 negatively regulates rRNA expression" lcl|NW_020311316.1_prot_XP_012269016.1_3161 6 KEGG: 00630+4.2.1.3;KEGG: 00290+4.2.1.33;Reactome: R-HSA-1268020;KEGG: 00720+4.2.1.3;KEGG: 00020+4.2.1.3;Reactome: R-HSA-71403 "Glyoxylate and dicarboxylate metabolism";"Valine, leucine and isoleucine biosynthesis";"Mitochondrial protein import";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)" lcl|NW_020311357.1_prot_XP_012259644.1_5652 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311511.1_prot_XP_012250947.1_9669 2 Reactome: R-HSA-8873719;Reactome: R-HSA-6803205 "RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" lcl|NW_020311995.1_prot_XP_020708248.1_21906 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311961.1_prot_XP_012262542.1_13238 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311302.1_prot_XP_025602691.1_1712 4 Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-3769402 "Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex" lcl|NW_020311918.1_prot_XP_012265134.1_10391 5 MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922 "Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)" lcl|NW_020311961.1_prot_XP_012262665.1_13418 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6784531 "Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus" lcl|NW_020311361.1_prot_XP_012261550.1_5803 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311966.1_prot_XP_012252984.1_14527 1 Reactome: R-HSA-373752 "Netrin-1 signaling" lcl|NW_020311436.1_prot_XP_012258116.1_8768 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311966.1_prot_XP_012256490.1_14884 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311994.1_prot_XP_020711906.1_21743 5 KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7269;MetaCyc: PWY-7268;MetaCyc: PWY-5083 "Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation" lcl|NW_020311988.1_prot_XP_020709730.1_20704 3 Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081 "Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling" lcl|NW_020311380.1_prot_XP_012268220.1_6753 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" lcl|NW_020311985.1_prot_XP_012253801.1_20291 9 Reactome: R-HSA-1475029;MetaCyc: PWY-5744;KEGG: 00910+4.2.1.1;MetaCyc: PWY-241;MetaCyc: PWY-7117;MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142 "Reversible hydration of carbon dioxide";"Glyoxylate assimilation";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)" lcl|NW_020311918.1_prot_XP_012265133.1_10412 8 KEGG: 00230+3.5.4.4;Reactome: R-HSA-6798695;Reactome: R-HSA-74217;Reactome: R-HSA-5683826;MetaCyc: PWY-7179-1;MetaCyc: PWY-7179;MetaCyc: PWY-6609;MetaCyc: PWY-6611 "Purine metabolism";"Neutrophil degranulation";"Purine salvage";"Surfactant metabolism";"Purine deoxyribonucleosides degradation II";"Purine deoxyribonucleosides degradation I";"Adenine and adenosine salvage III";"Adenine and adenosine salvage V" lcl|NW_020311396.1_prot_XP_012269592.1_7280 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311925.1_prot_XP_012265827.1_10571 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311983.1_prot_XP_020707880.1_19792 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311309.1_prot_XP_012259148.1_2345 5 Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-68962;Reactome: R-HSA-68827;Reactome: R-HSA-69205 "Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex";"G1/S-Specific Transcription" lcl|NW_020311368.1_prot_XP_012264427.1_6217 4 Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311977.1_prot_XP_025602752.1_17729 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311976.1_prot_XP_012253443.1_17219 2 Reactome: R-HSA-983168;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation" lcl|NW_020311298.1_prot_XP_012250608.1_1369 13 Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72689 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits" lcl|NW_020311975.1_prot_XP_012266008.1_17197 60 KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-7606;KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.211;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-7401;MetaCyc: PWY-1361;KEGG: 00281+4.2.1.17;MetaCyc: PWY-7007;Reactome: R-HSA-1482798;KEGG: 00640+4.2.1.17;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-5789;MetaCyc: PWY-6944;MetaCyc: PWY-7779;KEGG: 00062+4.2.1.17+1.1.1.211;MetaCyc: PWY-6583;MetaCyc: PWY-5138;MetaCyc: PWY-7778;MetaCyc: PWY-6945;KEGG: 00930+4.2.1.17;Reactome: R-HSA-77350;KEGG: 00720+4.2.1.17;KEGG: 00071+4.2.1.17+1.1.1.35;Reactome: R-HSA-77348;MetaCyc: PWY-7094;MetaCyc: PWY-7216;MetaCyc: PWY-6946;MetaCyc: PWY-6863;KEGG: 00280+4.2.1.17;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;KEGG: 00362+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;Reactome: R-HSA-77288;MetaCyc: PWY-5109;Reactome: R-HSA-77310;KEGG: 00650+4.2.1.17;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;MetaCyc: PWY-6883;MetaCyc: PWY-7654;MetaCyc: PWY-7726;KEGG: 00903+4.2.1.17;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00623+1.1.1.35;KEGG: 00310+4.2.1.17;Reactome: R-HSA-77285;MetaCyc: PWY-5177;KEGG: 00410+4.2.1.17;Reactome: R-HSA-77346;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00592+4.2.1.17;MetaCyc: PWY-5136;KEGG: 00380+4.2.1.17;Reactome: R-HSA-77305 "Fatty acid degradation";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Carbon fixation pathways in prokaryotes";"Aminobenzoate degradation";"Fatty acid elongation";"Phenylalanine metabolism";"Butanoate metabolism";"Fatty acid degradation";"Valine, leucine and isoleucine degradation";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Benzoyl-coa degradation I (aerobic)";"Geraniol degradation";"Methyl ketone biosynthesis (engineered)";"Acyl chain remodeling of CL";"Propanoate metabolism";"Caprolactam degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Androstenedione degradation";"Methyl tert-butyl ether degradation";"Fatty acid elongation";"Pyruvate fermentation to butanol I";"Fatty acid beta-oxidation IV (unsaturated, even number)";"2-methylpropene degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Caprolactam degradation";"Beta oxidation of hexanoyl-CoA to butanoyl-CoA";"Carbon fixation pathways in prokaryotes";"Fatty acid degradation";"Beta oxidation of octanoyl-CoA to hexanoyl-CoA";"Fatty acid salvage";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Pyruvate fermentation to hexanol (engineered)";"Valine, leucine and isoleucine degradation";"Geraniol degradation";"Spodoptera littoralis pheromone biosynthesis";"Benzoate degradation";"Butanoate metabolism";"mitochondrial fatty acid beta-oxidation of unsaturated fatty acids";"Fermentation to 2-methylbutanoate";"Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA";"Butanoate metabolism";"Tryptophan metabolism";"4-hydroxybenzoate biosynthesis III (plants)";"Pyruvate fermentation to butanol II (engineered)";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Limonene and pinene degradation";"Benzoate degradation";"Toluene degradation";"Lysine degradation";"Beta oxidation of myristoyl-CoA to lauroyl-CoA";"Glutaryl-coa degradation";"beta-Alanine metabolism";"Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA";"Lysine degradation";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Tryptophan metabolism";"Beta oxidation of palmitoyl-CoA to myristoyl-CoA" lcl|NW_020311993.1_prot_XP_012263215.1_21347 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311966.1_prot_XP_012256573.1_14834 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311976.1_prot_XP_012257407.1_17357 9 Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-1368082;Reactome: R-HSA-5617472;Reactome: R-HSA-400206;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-1368108;Reactome: R-HSA-2151201 "Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"RORA activates gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311375.1_prot_XP_020708263.1_6560 1 Reactome: R-HSA-1296061 "HCN channels" lcl|NW_020311977.1_prot_XP_012253843.2_17567 14 MetaCyc: PWY-6538;KEGG: 00230+1.17.1.4+1.17.3.2;Reactome: R-HSA-8851680;MetaCyc: PWY-5497;MetaCyc: PWY-6999;MetaCyc: PWY-6606;MetaCyc: PWY-6608;KEGG: 00232+1.17.3.2;Reactome: R-HSA-74259;KEGG: 00983+1.17.3.2;MetaCyc: PWY-5695;KEGG: 00230+1.17.1.4;MetaCyc: PWY-6596;MetaCyc: PWY-6607 "Caffeine degradation III (bacteria, via demethylation)";"Purine metabolism";"Butyrophilin (BTN) family interactions";"Purine nucleobases degradation II (anaerobic)";"Theophylline degradation";"Guanosine nucleotides degradation II";"Guanosine nucleotides degradation III";"Caffeine metabolism";"Purine catabolism";"Drug metabolism - other enzymes";"Inosine 5'-phosphate degradation";"Purine metabolism";"Adenosine nucleotides degradation I";"Guanosine nucleotides degradation I" lcl|NW_020311956.1_prot_XP_012251350.1_12644 2 Reactome: R-HSA-1237112;KEGG: 00270+3.1.3.77 "Methionine salvage pathway";"Cysteine and methionine metabolism" lcl|NW_020311315.1_prot_XP_012265278.1_3107 19 Reactome: R-HSA-5687128;Reactome: R-HSA-525793;Reactome: R-HSA-5627123;Reactome: R-HSA-8964616;Reactome: R-HSA-983231;Reactome: R-HSA-5625970;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-182971;Reactome: R-HSA-5663220;Reactome: R-HSA-4420097;Reactome: R-HSA-428543;Reactome: R-HSA-3928662;Reactome: R-HSA-5626467;Reactome: R-HSA-5663213;Reactome: R-HSA-389359;Reactome: R-HSA-8950505;Reactome: R-HSA-418885;Reactome: R-HSA-2029482 "MAPK6/MAPK4 signaling";"Myogenesis";"RHO GTPases activate PAKs";"G beta:gamma signalling through CDC42";"Factors involved in megakaryocyte development and platelet production";"RHO GTPases activate KTN1";"Rho GTPase cycle";"GPVI-mediated activation cascade";"EGFR downregulation";"RHO GTPases Activate Formins";"VEGFA-VEGFR2 Pathway";"Inactivation of CDC42 and RAC1";"EPHB-mediated forward signaling";"RHO GTPases activate IQGAPs";"RHO GTPases Activate WASPs and WAVEs";"CD28 dependent Vav1 pathway";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"DCC mediated attractive signaling";"Regulation of actin dynamics for phagocytic cup formation" lcl|NW_020311312.1_prot_XP_012266940.1_2590 14 Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-5620924;Reactome: R-HSA-6811436;Reactome: R-HSA-1632852;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-6807878 "Aggrephagy";"Separation of Sister Chromatids";"Intraflagellar transport";"COPI-independent Golgi-to-ER retrograde traffic";"Macroautophagy";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"HCMV Early Events";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"COPI-mediated anterograde transport" lcl|NW_020311974.1_prot_XP_020709391.1_16926 2 Reactome: R-HSA-202733;Reactome: R-HSA-416993 "Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors" lcl|NW_020311368.1_prot_XP_012264431.1_6213 4 Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "DARPP-32 events";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311332.1_prot_XP_012256531.1_4191 14 MetaCyc: PWY-7782;KEGG: 00565+3.1.3.4;Reactome: R-HSA-1483191;MetaCyc: PWY-6453;MetaCyc: PWY-8051;Reactome: R-HSA-75109;KEGG: 00564+3.1.3.4;KEGG: 00561+3.1.3.4;MetaCyc: PWY-8052;Reactome: R-HSA-1483213;KEGG: 00600+3.1.3.4;Reactome: R-HSA-4419969;MetaCyc: PWY-8053;MetaCyc: PWY-8055 "Plasmalogen biosynthesis";"Ether lipid metabolism";"Synthesis of PC";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Triglyceride biosynthesis";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"2-arachidonoylglycerol biosynthesis";"Synthesis of PE";"Sphingolipid metabolism";"Depolymerisation of the Nuclear Lamina";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis" lcl|NW_020311966.1_prot_XP_012251692.1_14567 2 MetaCyc: PWY-7800;MetaCyc: PWY-7799 "Ac/N-end rule pathway";"Arg/N-end rule pathway (eukaryotic)" lcl|NW_020311320.1_prot_XP_012267565.1_3376 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" lcl|NW_020311292.1_prot_XP_012262854.1_688 4 Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-419037 "Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"NCAM1 interactions" lcl|NW_020311429.1_prot_XP_012265645.1_8285 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" lcl|NW_020311407.1_prot_XP_020707773.1_7786 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311424.1_prot_XP_012255420.1_8217 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" lcl|NW_020311441.1_prot_XP_012251178.1_8867 9 Reactome: R-HSA-113501;Reactome: R-HSA-69183;Reactome: R-HSA-68962;Reactome: R-HSA-69205;Reactome: R-HSA-174430;Reactome: R-HSA-174411;Reactome: R-HSA-68952;Reactome: R-HSA-69091;Reactome: R-HSA-69166 "Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Processive synthesis on the lagging strand";"Activation of the pre-replicative complex";"G1/S-Specific Transcription";"Telomere C-strand synthesis initiation";"Polymerase switching on the C-strand of the telomere";"DNA replication initiation";"Polymerase switching";"Removal of the Flap Intermediate" lcl|NW_020311955.1_prot_XP_012265448.1_12471 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311413.1_prot_XP_012254393.1_7896 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311977.1_prot_XP_012253839.1_17573 4 Reactome: R-HSA-379716;Reactome: R-HSA-2408522;Reactome: R-HSA-379726;KEGG: 00970+6.1.1.18 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311988.1_prot_XP_025602942.1_20740 14 MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7725 "Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)" lcl|NW_020311994.1_prot_XP_012267417.1_21555 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311313.1_prot_XP_012261895.1_3050 26 Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-437239;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-389977;Reactome: R-HSA-1445148;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-389960;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-190861;Reactome: R-HSA-5617833;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276 "Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Recycling pathway of L1";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"Post-chaperonin tubulin folding pathway";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Formation of tubulin folding intermediates by CCT/TriC";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"Gap junction assembly";"Cilium Assembly";"Kinesins";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint" lcl|NW_020311365.1_prot_XP_020712482.1_5989 4 Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" lcl|NW_020311311.1_prot_XP_020706375.1_2560 17 Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-141430;Reactome: R-HSA-179409;Reactome: R-HSA-176408;Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-174048;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-8853884 "Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC-Cdc20 mediated degradation of Nek2A";"Regulation of APC/C activators between G1/S and early anaphase";"Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"APC/C:Cdc20 mediated degradation of Cyclin B";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Transcriptional Regulation by VENTX" lcl|NW_020311325.1_prot_XP_012251430.1_3679 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" lcl|NW_020311971.1_prot_XP_012263515.1_16091 4 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.18;Reactome: R-HSA-379716;Reactome: R-HSA-2408522 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism" lcl|NW_020311339.1_prot_XP_020707293.1_4643 7 Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-4615885;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"SUMOylation of DNA replication proteins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311973.1_prot_XP_012258728.1_16330 42 KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-7606;MetaCyc: PWY-1361;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-7401;KEGG: 00640+4.2.1.17;MetaCyc: PWY-7007;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-6583;MetaCyc: PWY-7778;MetaCyc: PWY-5138;MetaCyc: PWY-6945;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;MetaCyc: PWY-5789;MetaCyc: PWY-6944;MetaCyc: PWY-7094;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-6863;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-7216;MetaCyc: PWY-6946;MetaCyc: PWY-5109;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;KEGG: 00623+1.1.1.35;MetaCyc: PWY-6435;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-6883;MetaCyc: PWY-7654;MetaCyc: PWY-7726;KEGG: 00592+4.2.1.17;MetaCyc: PWY-5136;MetaCyc: PWY-5177;KEGG: 00410+4.2.1.17;KEGG: 00310+4.2.1.17+1.1.1.35 "Carbon fixation pathways in prokaryotes";"Aminobenzoate degradation";"Fatty acid elongation";"Phenylalanine metabolism";"Fatty acid degradation";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Benzoyl-coa degradation I (aerobic)";"Valine, leucine and isoleucine degradation";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Propanoate metabolism";"Methyl ketone biosynthesis (engineered)";"Butanoate metabolism";"Pyruvate fermentation to butanol I";"2-methylpropene degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Caprolactam degradation";"Methyl tert-butyl ether degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Androstenedione degradation";"Fatty acid salvage";"Fatty acid degradation";"Pyruvate fermentation to hexanol (engineered)";"Geraniol degradation";"Spodoptera littoralis pheromone biosynthesis";"Butanoate metabolism";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Fermentation to 2-methylbutanoate";"Benzoate degradation";"Limonene and pinene degradation";"Toluene degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Tryptophan metabolism";"Pyruvate fermentation to butanol II (engineered)";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Glutaryl-coa degradation";"beta-Alanine metabolism";"Lysine degradation" lcl|NW_020311966.1_prot_XP_012256513.1_14770 3 Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340 "PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311298.1_prot_XP_020706314.1_1132 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311294.1_prot_XP_012264904.1_886 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311951.1_prot_XP_012259245.1_12210 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311317.1_prot_XP_025603079.1_3198 31 MetaCyc: PWY-6519;MetaCyc: PWY-5147;Reactome: R-HSA-2426168;MetaCyc: PWY-5973;Reactome: R-HSA-163765;Reactome: R-HSA-75105;Reactome: R-HSA-199220;MetaCyc: PWY-5367;MetaCyc: PWY-4381;MetaCyc: PWY-5142;MetaCyc: PWYG-321;MetaCyc: PWY-6113;MetaCyc: PWY-7858;MetaCyc: PWY-7663;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5366;MetaCyc: PWY-7723;MetaCyc: PWY-8049;MetaCyc: PWY-5966-1;MetaCyc: PWY-7664;MetaCyc: PWY-6282;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-9029558;MetaCyc: PWY-7388;MetaCyc: PWY-6799;MetaCyc: PWY-5994;MetaCyc: PWY-8012;MetaCyc: PWY-5971;MetaCyc: PWY-7746;MetaCyc: PWY-8047;MetaCyc: PWY-5989 "8-amino-7-oxononanoate biosynthesis I";"Oleate biosynthesis I (plants)";"Activation of gene expression by SREBF (SREBP)";"Cis-vaccenate biosynthesis";"ChREBP activates metabolic gene expression";"Fatty acyl-CoA biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Acyl-[acyl-carrier protein] thioesterase pathway";"";"Superpathway of mycolate biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Gondoate biosynthesis (anaerobic)";"Fatty acid biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Bacterial bioluminescence";"Pederin biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Oleate biosynthesis IV (anaerobic)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Biotin metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Mupirocin biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Mycobacterial sulfolipid biosynthesis";"Bryostatin biosynthesis";"Stearate biosynthesis II (bacteria and plants)" lcl|NW_020311407.1_prot_XP_012255310.1_7794 5 Reactome: R-HSA-381183;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-9614657;Reactome: R-HSA-380994 "ATF6 (ATF6-alpha) activates chaperone genes";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"FOXO-mediated transcription of cell death genes";"ATF4 activates genes in response to endoplasmic reticulum stress" lcl|NW_020311966.1_prot_XP_012256510.1_14757 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311424.1_prot_XP_020707851.1_8225 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311975.1_prot_XP_020706570.1_17058 4 KEGG: 00670+2.1.2.9;KEGG: 00970+2.1.2.9;KEGG: 00670+1.5.1.6;Reactome: R-HSA-196757 "One carbon pool by folate";"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"Metabolism of folate and pterines" lcl|NW_020311325.1_prot_XP_020706476.1_3663 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311995.1_prot_XP_012256659.1_22051 2 KEGG: 00071+2.3.1.21;MetaCyc: PWY-6111 "Fatty acid degradation";"Mitochondrial L-carnitine shuttle" lcl|NW_020311992.1_prot_XP_012266535.1_21071 2 Reactome: R-HSA-72764;Reactome: R-HSA-156581 "Eukaryotic Translation Termination";"Methylation" lcl|NW_020311994.1_prot_XP_012267606.1_21532 4 Reactome: R-HSA-4719360;Reactome: R-HSA-162699;Reactome: R-HSA-4719377;Reactome: R-HSA-4717374 "Defective DPM3 causes DPM3-CDG (CDG-1o)";"Synthesis of dolichyl-phosphate mannose";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM1 causes DPM1-CDG (CDG-1e)" lcl|NW_020311968.1_prot_XP_025602614.1_15397 9 Reactome: R-HSA-4420332;Reactome: R-HSA-3656253;Reactome: R-HSA-975634;Reactome: R-HSA-3560801;Reactome: R-HSA-2022928;Reactome: R-HSA-1971475;Reactome: R-HSA-3560783;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096 "Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Retinoid metabolism and transport";"Defective B3GAT3 causes JDSSDHD";"HS-GAG biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B4GALT7 causes EDS, progeroid type";"Defective EXT2 causes exostoses 2";"HS-GAG degradation" lcl|NW_020311992.1_prot_XP_025602968.1_21213 2 Reactome: R-HSA-983168;Reactome: R-HSA-6798695 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation" lcl|NW_020311961.1_prot_XP_012262483.1_13346 3 KEGG: 00230+1.7.3.3;KEGG: 00232+1.7.3.3;MetaCyc: PWY-5691 "Purine metabolism";"Caffeine metabolism";"Urate conversion to allantoin I" lcl|NW_020311918.1_prot_XP_020710252.1_10299 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" lcl|NW_020311988.1_prot_XP_020706221.1_20623 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311990.1_prot_XP_020711561.1_20803 5 Reactome: R-HSA-199220;MetaCyc: PWY-6012-1;MetaCyc: PWY-6012;KEGG: 00770+2.7.8.7;MetaCyc: PWY-6289 "Vitamin B5 (pantothenate) metabolism";"Acyl carrier protein activation";"Acyl carrier protein metabolism";"Pantothenate and CoA biosynthesis";"Petrobactin biosynthesis" lcl|NW_020311472.1_prot_XP_012269195.1_9366 13 MetaCyc: PWY-7883;Reactome: R-HSA-2160916;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;MetaCyc: PWY-6902;Reactome: R-HSA-2022857;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-1660662;KEGG: 00513+3.2.1.52 "Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation";"Glycosphingolipid biosynthesis - ganglio series";"Chitin degradation III (Serratia)";"CS/DS degradation";"Chitin degradation II (Vibrio)";"Keratan sulfate degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid metabolism";"Various types of N-glycan biosynthesis" lcl|NW_020311315.1_prot_XP_020711124.1_3131 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311975.1_prot_NP_001295472.1_17195 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" lcl|NW_020311436.1_prot_XP_012258372.1_8760 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" lcl|NW_020311978.1_prot_XP_012257896.1_18189 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311982.1_prot_XP_012258296.1_19294 5 Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-983712 "Amino acids regulate mTORC1";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Ion channel transport" lcl|NW_020311943.1_prot_XP_012254981.1_11668 3 KEGG: 00260+3.1.3.3;Reactome: R-HSA-977347;KEGG: 00680+3.1.3.3 "Glycine, serine and threonine metabolism";"Serine biosynthesis";"Methane metabolism" lcl|NW_020311313.1_prot_XP_012261848.1_2905 2 Reactome: R-HSA-6783984;Reactome: R-HSA-389661 "Glycine degradation";"Glyoxylate metabolism and glycine degradation" lcl|NW_020311477.1_prot_XP_012262346.1_9447 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" lcl|NW_020311300.1_prot_XP_020707118.1_1492 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311513.1_prot_XP_012266065.1_9821 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311292.1_prot_XP_012252544.1_594 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" lcl|NW_020311513.1_prot_XP_012266123.1_9842 4 KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943 "Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates" lcl|NW_020311962.1_prot_XP_012252129.1_13809 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311338.1_prot_XP_012263068.1_4534 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" lcl|NW_020311313.1_prot_XP_020709862.1_2845 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311971.1_prot_XP_012260895.1_15935 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311966.1_prot_XP_012256998.1_15090 8 Reactome: R-HSA-9639288;Reactome: R-HSA-1632852;Reactome: R-HSA-3371571;Reactome: R-HSA-165159;Reactome: R-HSA-8943724;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-5628897 "Amino acids regulate mTORC1";"Macroautophagy";"HSF1-dependent transactivation";"mTOR signalling";"Regulation of PTEN gene transcription";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes" lcl|NW_020311304.1_prot_XP_012261082.1_1889 5 Reactome: R-HSA-6811558;Reactome: R-HSA-5673001;Reactome: R-HSA-2219530;Reactome: R-HSA-1257604;Reactome: R-HSA-109704 "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RAF/MAP kinase cascade";"Constitutive Signaling by Aberrant PI3K in Cancer";"PIP3 activates AKT signaling";"PI3K Cascade" lcl|NW_020311976.1_prot_XP_012257414.1_17358 9 Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-2426168;Reactome: R-HSA-400206;Reactome: R-HSA-5617472;Reactome: R-HSA-1368082;Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-400253 "BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"Activation of gene expression by SREBF (SREBP)";"Regulation of lipid metabolism by PPARalpha";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RORA activates gene expression";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock" lcl|NW_020311978.1_prot_XP_012258088.1_18131 3 Reactome: R-HSA-9029569;Reactome: R-HSA-1369062;Reactome: R-HSA-8964058 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"ABC transporters in lipid homeostasis";"HDL remodeling" lcl|NW_020311309.1_prot_XP_012259069.1_2376 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311334.1_prot_XP_012265946.1_4399 13 Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-9010553 "L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311976.1_prot_XP_012253440.1_17222 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311513.1_prot_XP_020711385.1_9885 6 KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952;MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578 "Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway" lcl|NW_020311940.1_prot_XP_020711235.1_11235 6 MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782 "Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311290.1_prot_XP_020706900.1_437 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311292.1_prot_XP_012252547.1_645 2 Reactome: R-HSA-1632852;Reactome: R-HSA-1660499 "Macroautophagy";"Synthesis of PIPs at the plasma membrane" lcl|NW_020311939.1_prot_XP_012263492.1_11052 2 Reactome: R-HSA-5696394;Reactome: R-HSA-5689603 "DNA Damage Recognition in GG-NER";"UCH proteinases" lcl|NW_020311324.1_prot_XP_012269308.1_3590 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311388.1_prot_XP_020710952.1_6997 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311292.1_prot_XP_012252446.1_650 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311334.1_prot_XP_025601750.1_4341 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311993.1_prot_XP_020710516.1_21367 2 MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311388.1_prot_XP_012264835.1_6958 2 Reactome: R-HSA-376176;Reactome: R-HSA-202433 "Signaling by ROBO receptors";"Generation of second messenger molecules" lcl|NW_020311971.1_prot_XP_012263532.1_16073 3 Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing" lcl|NW_020311975.1_prot_XP_020706657.1_16968 4 Reactome: R-HSA-211976;Reactome: R-HSA-5579026;Reactome: R-HSA-2395516;Reactome: R-HSA-196108 "Endogenous sterols";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Electron transport from NADPH to Ferredoxin";"Pregnenolone biosynthesis" lcl|NW_020311433.1_prot_XP_012263841.1_8653 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" lcl|NW_020311346.1_prot_XP_020710327.1_4995 2 Reactome: R-HSA-418555;Reactome: R-HSA-419812 "G alpha (s) signalling events";"Calcitonin-like ligand receptors" lcl|NW_020311988.1_prot_XP_012268691.1_20480 32 Reactome: R-HSA-73779;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-75955;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-72165;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-8851708;Reactome: R-HSA-77075;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-76042;Reactome: R-HSA-167158;Reactome: R-HSA-112382;Reactome: R-HSA-167242;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"RNA Polymerase II Transcription Elongation";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"Signaling by FGFR2 IIIa TM";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of the HIV-1 Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes" lcl|NW_020311934.1_prot_XP_012254840.1_10870 1 Reactome: R-HSA-380972 "Energy dependent regulation of mTOR by LKB1-AMPK" lcl|NW_020311990.1_prot_XP_012266447.1_20854 2 KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1 "Purine metabolism";"Pentose phosphate pathway" lcl|NW_020311965.1_prot_XP_020709431.1_14139 1 Reactome: R-HSA-5693568 "Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311304.1_prot_XP_012261277.1_1812 6 Reactome: R-HSA-139915;Reactome: R-HSA-6804759;Reactome: R-HSA-6803211;Reactome: R-HSA-6803207;Reactome: R-HSA-6803205;Reactome: R-HSA-6803204 "Activation of PUMA and translocation to mitochondria";"Regulation of TP53 Activity through Association with Co-factors";"TP53 Regulates Transcription of Death Receptors and Ligands";"TP53 Regulates Transcription of Caspase Activators and Caspases";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" lcl|NW_020311287.1_prot_XP_012268127.1_253 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311559.1_prot_XP_020712363.1_10044 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311432.1_prot_XP_012268788.1_8479 6 Reactome: R-HSA-418592;Reactome: R-HSA-416476;Reactome: R-HSA-399997;Reactome: R-HSA-428930;Reactome: R-HSA-434316;Reactome: R-HSA-456926 "ADP signalling through P2Y purinoceptor 1";"G alpha (q) signalling events";"Acetylcholine regulates insulin secretion";"Thromboxane signalling through TP receptor";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)" lcl|NW_020311334.1_prot_XP_020711361.1_4378 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311424.1_prot_XP_012255431.1_8237 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311965.1_prot_XP_012259446.1_14299 3 MetaCyc: PWY-6689;Reactome: R-HSA-6784531;MetaCyc: PWY-7803 "Trna splicing I";"tRNA processing in the nucleus";"Trna splicing II" lcl|NW_020311967.1_prot_XP_012254364.1_15292 1 Reactome: R-HSA-606279 "Deposition of new CENPA-containing nucleosomes at the centromere" lcl|NW_020311401.1_prot_XP_020707763.1_7530 6 KEGG: 04070+2.7.11.13;Reactome: R-HSA-1489509;Reactome: R-HSA-114508;Reactome: R-HSA-418597;Reactome: R-HSA-2029485;Reactome: R-HSA-1250196 "Phosphatidylinositol signaling system";"DAG and IP3 signaling";"Effects of PIP2 hydrolysis";"G alpha (z) signalling events";"Role of phospholipids in phagocytosis";"SHC1 events in ERBB2 signaling" lcl|NW_020311943.1_prot_XP_012255154.1_11644 3 KEGG: 00250+3.5.1.1;KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693 "Alanine, aspartate and glutamate metabolism";"Cyanoamino acid metabolism";"Aspartate and asparagine metabolism" lcl|NW_020311915.1_prot_XP_012262240.1_10197 8 KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04151+2.7.11.1 "Thermogenesis";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Major pathway of rRNA processing in the nucleolus and cytosol";"PI3K-Akt signaling pathway" lcl|NW_020311955.1_prot_XP_012265461.1_12349 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311955.1_prot_XP_020711179.1_12480 6 MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23 "Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Other glycan degradation";"Galactose metabolism" lcl|NW_020311346.1_prot_XP_020710320.1_5004 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311983.1_prot_XP_012255630.1_19809 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311983.1_prot_XP_012255621.1_19728 2 Reactome: R-HSA-5339700;Reactome: R-HSA-4641265 "TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes" lcl|NW_020311403.1_prot_XP_020708790.1_7729 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311972.1_prot_XP_012267922.1_16281 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311377.1_prot_XP_020712176.1_6580 6 Reactome: R-HSA-3769402;Reactome: R-HSA-4086398;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-8951430;Reactome: R-HSA-4411364 "Deactivation of the beta-catenin transactivating complex";"Ca2+ pathway";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters" lcl|NW_020311291.1_prot_XP_012259522.1_471 1 Reactome: R-HSA-1660499 "Synthesis of PIPs at the plasma membrane" lcl|NW_020311292.1_prot_XP_020710258.1_682 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-5576892 "NCAM1 interactions";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation" lcl|NW_020311934.1_prot_XP_012255031.1_10829 1 Reactome: R-HSA-5389840 "Mitochondrial translation elongation" lcl|NW_020311984.1_prot_XP_012267660.1_20143 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311459.1_prot_XP_012260609.1_9169 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311971.1_prot_XP_012260925.1_15959 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311956.1_prot_XP_012254592.1_12577 4 Reactome: R-HSA-5625970;Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295 "RHO GTPases activate KTN1";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation" lcl|NW_020311372.1_prot_XP_012268403.1_6331 2 KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557 "T cell receptor signaling pathway";"Signaling by SCF-KIT" lcl|NW_020311314.1_prot_XP_012252169.1_3083 4 MetaCyc: PWY-7494;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163;MetaCyc: PWY-3722 "Choline degradation IV";"Glycine, serine and threonine metabolism";"Choline catabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)" lcl|NW_020311980.1_prot_XP_012255785.1_18914 26 Reactome: R-HSA-9614657;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-1234158;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-3899300;Reactome: R-HSA-2122947;Reactome: R-HSA-5617472;Reactome: R-HSA-3371568;Reactome: R-HSA-918233;Reactome: R-HSA-933541;Reactome: R-HSA-9018519;Reactome: R-HSA-9013695;Reactome: R-HSA-3134973;Reactome: R-HSA-1912408;Reactome: R-HSA-201722;Reactome: R-HSA-8941856;Reactome: R-HSA-5621575;Reactome: R-HSA-1368082;Reactome: R-HSA-210744;Reactome: R-HSA-3214847;Reactome: R-HSA-1989781;Reactome: R-HSA-8866907;Reactome: R-HSA-9013508;Reactome: R-HSA-9617629 "FOXO-mediated transcription of cell death genes";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulation of gene expression by Hypoxia-inducible Factor";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"SUMOylation of transcription cofactors";"NOTCH1 Intracellular Domain Regulates Transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Attenuation phase";"TRAF3-dependent IRF activation pathway";"TRAF6 mediated IRF7 activation";"Estrogen-dependent gene expression";"NOTCH4 Intracellular Domain Regulates Transcription";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Pre-NOTCH Transcription and Translation";"Formation of the beta-catenin:TCF transactivating complex";"RUNX3 regulates NOTCH signaling";"CD209 (DC-SIGN) signaling";"RORA activates gene expression";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"HATs acetylate histones";"PPARA activates gene expression";"Activation of the TFAP2 (AP-2) family of transcription factors";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation" lcl|NW_020311979.1_prot_XP_025602811.1_18544 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311325.1_prot_XP_012250840.1_3671 5 Reactome: R-HSA-5675221;Reactome: R-HSA-5673000;Reactome: R-HSA-9649948;Reactome: R-HSA-6802946;Reactome: R-HSA-6802955 "Negative regulation of MAPK pathway";"RAF activation";"Signaling downstream of RAS mutants";"Signaling by moderate kinase activity BRAF mutants";"Paradoxical activation of RAF signaling by kinase inactive BRAF" lcl|NW_020311995.1_prot_XP_012256974.2_21990 5 Reactome: R-HSA-3232118;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-5693565 "SUMOylation of transcription factors";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" lcl|NW_020311917.1_prot_XP_020706448.1_10241 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311926.1_prot_XP_012250749.1_10645 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311305.1_prot_XP_012263797.1_2000 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311983.1_prot_XP_012267169.1_19448 7 KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311338.1_prot_XP_020710334.1_4533 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" lcl|NW_020311978.1_prot_XP_012258043.1_18285 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311992.1_prot_XP_012260886.1_20963 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311961.1_prot_XP_025602491.1_13265 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311286.1_prot_XP_020708336.1_46 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection" lcl|NW_020311304.1_prot_XP_012260842.1_1787 3 MetaCyc: PWY-7999;KEGG: 00130+1.17.4.4;Reactome: R-HSA-6806664 "Vitamin K-epoxide cycle";"Ubiquinone and other terpenoid-quinone biosynthesis";"Metabolism of vitamin K" lcl|NW_020311407.1_prot_XP_012255309.1_7793 5 Reactome: R-HSA-1989781;Reactome: R-HSA-381183;Reactome: R-HSA-380994;Reactome: R-HSA-9614657;Reactome: R-HSA-2426168 "PPARA activates gene expression";"ATF6 (ATF6-alpha) activates chaperone genes";"ATF4 activates genes in response to endoplasmic reticulum stress";"FOXO-mediated transcription of cell death genes";"Activation of gene expression by SREBF (SREBP)" lcl|NW_020311286.1_prot_XP_012256248.1_130 4 MetaCyc: PWY-5642;KEGG: 00280+1.2.1.27;Reactome: R-HSA-70895;KEGG: 00640+1.2.1.27 "2,4-dinitrotoluene degradation";"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism";"Propanoate metabolism" lcl|NW_020311961.1_prot_XP_012262711.1_13251 1 MetaCyc: PWY-6829 "Trna methylation (yeast)" lcl|NW_020311970.1_prot_XP_012267426.1_15806 6 Reactome: R-HSA-1655829;Reactome: R-HSA-381033;Reactome: R-HSA-381426;Reactome: R-HSA-8963889;Reactome: R-HSA-8957275;Reactome: R-HSA-8874211 "Regulation of cholesterol biosynthesis by SREBP (SREBF)";"ATF6 (ATF6-alpha) activates chaperones";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Assembly of active LPL and LIPC lipase complexes";"Post-translational protein phosphorylation";"CREB3 factors activate genes" lcl|NW_020311977.1_prot_XP_012263944.1_17827 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311975.1_prot_XP_020706925.1_17018 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311955.1_prot_XP_012265450.1_12502 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311985.1_prot_XP_020711106.1_20253 1 Reactome: R-HSA-1483148 "Synthesis of PG" lcl|NW_020311955.1_prot_XP_012265328.1_12493 1 Reactome: R-HSA-191859 "snRNP Assembly" lcl|NW_020311983.1_prot_XP_012267227.2_19491 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" lcl|NW_020311977.1_prot_XP_012263675.1_17794 17 MetaCyc: PWY-5743;KEGG: 00620+6.4.1.2;MetaCyc: PWY-5789;MetaCyc: PWY-5744;MetaCyc: PWY-5966-1;KEGG: 00720+6.4.1.2;MetaCyc: PWY-6722;KEGG: 00061+6.4.1.2;Reactome: R-HSA-200425;Reactome: R-HSA-2426168;KEGG: 00254+6.4.1.2;Reactome: R-HSA-3371599;Reactome: R-HSA-163765;MetaCyc: PWY-4381;MetaCyc: PWY-6679;KEGG: 00640+6.4.1.2;Reactome: R-HSA-196780 "3-hydroxypropanoate cycle";"Pyruvate metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Glyoxylate assimilation";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Carbon fixation pathways in prokaryotes";"Candicidin biosynthesis";"Fatty acid biosynthesis";"Carnitine metabolism";"Activation of gene expression by SREBF (SREBP)";"Aflatoxin biosynthesis";"Defective HLCS causes multiple carboxylase deficiency";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (bacteria and plants)";"Jadomycin biosynthesis";"Propanoate metabolism";"Biotin transport and metabolism" lcl|NW_020311513.1_prot_XP_020711463.1_9871 4 Reactome: R-HSA-8849175;Reactome: R-HSA-5358493;MetaCyc: PWY-7546;MetaCyc: PWY-6482 "Threonine catabolism";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)" lcl|NW_020311976.1_prot_XP_012253550.1_17272 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311957.1_prot_XP_025602436.1_12768 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311957.1_prot_XP_025602437.1_12769 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311324.1_prot_XP_012269320.1_3545 4 Reactome: R-HSA-964975;MetaCyc: PWY-7282;KEGG: 00750+1.4.3.5;MetaCyc: PWY-7204 "Vitamins B6 activation to pyridoxal phosphate";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Vitamin B6 metabolism";"Pyridoxal 5'-phosphate salvage II (plants)" lcl|NW_020311983.1_prot_XP_012267144.1_19433 14 Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167243 "Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery" lcl|NW_020311934.1_prot_XP_012255135.1_10810 2 KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386 "Pyruvate metabolism";"Methylglyoxal degradation I" lcl|NW_020311961.1_prot_XP_012262651.1_13464 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311971.1_prot_XP_012260918.1_15830 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311982.1_prot_XP_020708733.1_19254 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311450.1_prot_XP_012260326.1_9036 3 Reactome: R-HSA-5358493;MetaCyc: PWY-7546;MetaCyc: PWY-6482 "Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)" lcl|NW_020311934.1_prot_XP_012255105.1_10788 4 Reactome: R-HSA-166058;Reactome: R-HSA-6799198;Reactome: R-HSA-975871;Reactome: R-HSA-975138 "MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"Complex I biogenesis";"MyD88 cascade initiated on plasma membrane";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation" lcl|NW_020311354.1_prot_XP_025601844.1_5471 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311981.1_prot_XP_012257585.1_19177 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311353.1_prot_XP_012255909.1_5423 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311934.1_prot_XP_012254913.1_10897 13 Reactome: R-HSA-3000171;Reactome: R-HSA-419037;Reactome: R-HSA-1442490;Reactome: R-HSA-2022090;Reactome: R-HSA-3000178;Reactome: R-HSA-186797;Reactome: R-HSA-3000157;Reactome: R-HSA-1474244;Reactome: R-HSA-216083;Reactome: R-HSA-1650814;Reactome: R-HSA-2214320;Reactome: R-HSA-2243919;Reactome: R-HSA-8948216 "Non-integrin membrane-ECM interactions";"NCAM1 interactions";"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures";"ECM proteoglycans";"Signaling by PDGF";"Laminin interactions";"Extracellular matrix organization";"Integrin cell surface interactions";"Collagen biosynthesis and modifying enzymes";"Anchoring fibril formation";"Crosslinking of collagen fibrils";"Collagen chain trimerization" lcl|NW_020311961.1_prot_XP_020710182.1_13534 5 Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-6804758 "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"Regulation of TP53 Activity through Acetylation" lcl|NW_020311971.1_prot_XP_012263565.1_16031 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311453.1_prot_XP_020706938.1_9063 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311977.1_prot_XP_012264000.1_17660 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311994.1_prot_XP_020710048.1_21847 4 Reactome: R-HSA-1650814;Reactome: R-HSA-2022090;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216 "Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures";"Collagen degradation";"Collagen chain trimerization" lcl|NW_020311290.1_prot_XP_012254142.1_423 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" lcl|NW_020311334.1_prot_XP_012265934.1_4351 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311981.1_prot_XP_012257435.1_18948 8 Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-8866652;Reactome: R-HSA-6804757;Reactome: R-HSA-8948747;Reactome: R-HSA-5689880;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823 "Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Regulation of TP53 Degradation";"Regulation of PTEN localization";"Ub-specific processing proteases";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex" lcl|NW_020311983.1_prot_XP_020711768.1_19487 3 Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-1358803 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Downregulation of ERBB2:ERBB3 signaling" lcl|NW_020311918.1_prot_XP_012264972.1_10314 1 Reactome: R-HSA-977443 "GABA receptor activation" lcl|NW_020311340.1_prot_XP_025601779.1_4671 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311969.1_prot_XP_020710969.1_15559 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311472.1_prot_XP_012269281.1_9339 3 Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340 "PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311367.1_prot_XP_012258958.1_6129 12 MetaCyc: PWY-6613;Reactome: R-HSA-73817;KEGG: 00230+2.1.2.2;MetaCyc: PWY-6122;KEGG: 00970+2.1.2.9;KEGG: 00230+6.3.4.13;KEGG: 00670+2.1.2.2;KEGG: 00230+6.3.3.1;MetaCyc: PWY-6121;MetaCyc: PWY-6277;Reactome: R-HSA-196780;KEGG: 00670+2.1.2.9 "Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis II";"Aminoacyl-tRNA biosynthesis";"Purine metabolism";"One carbon pool by folate";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Biotin transport and metabolism";"One carbon pool by folate" lcl|NW_020311346.1_prot_XP_020710326.1_4994 2 Reactome: R-HSA-418555;Reactome: R-HSA-419812 "G alpha (s) signalling events";"Calcitonin-like ligand receptors" lcl|NW_020311476.1_prot_XP_012254092.1_9419 5 KEGG: 00270+2.1.1.37;Reactome: R-HSA-212300;Reactome: R-HSA-427413;Reactome: R-HSA-5334118;Reactome: R-HSA-4655427 "Cysteine and methionine metabolism";"PRC2 methylates histones and DNA";"NoRC negatively regulates rRNA expression";"DNA methylation";"SUMOylation of DNA methylation proteins" lcl|NW_020311311.1_prot_XP_012250844.1_2518 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311432.1_prot_XP_012268782.1_8447 5 Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-5693565;Reactome: R-HSA-5689901 "G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Metalloprotease DUBs" lcl|NW_020311943.1_prot_XP_012254982.1_11669 3 KEGG: 00260+3.1.3.3;Reactome: R-HSA-977347;KEGG: 00680+3.1.3.3 "Glycine, serine and threonine metabolism";"Serine biosynthesis";"Methane metabolism" lcl|NW_020311973.1_prot_XP_012258743.1_16376 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" lcl|NW_020311396.1_prot_XP_012269567.1_7232 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311980.1_prot_XP_012261249.1_18843 6 Reactome: R-HSA-110357;Reactome: R-HSA-5651801;Reactome: R-HSA-110373;Reactome: R-HSA-73930;Reactome: R-HSA-73933;Reactome: R-HSA-110362 "Displacement of DNA glycosylase by APEX1";"PCNA-Dependent Long Patch Base Excision Repair";"Resolution of AP sites via the multiple-nucleotide patch replacement pathway";"Abasic sugar-phosphate removal via the single-nucleotide replacement pathway";"Resolution of Abasic Sites (AP sites)";"POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311993.1_prot_XP_020709840.1_21314 3 KEGG: 00531+3.2.1.50;Reactome: R-HSA-2206282;Reactome: R-HSA-2024096 "Glycosaminoglycan degradation";"MPS IIIB - Sanfilippo syndrome B";"HS-GAG degradation" lcl|NW_020311939.1_prot_XP_012251675.1_11064 20 Reactome: R-HSA-5693607;Reactome: R-HSA-5696400;Reactome: R-HSA-110312;Reactome: R-HSA-6804756;Reactome: R-HSA-110320;Reactome: R-HSA-5696397;Reactome: R-HSA-69473;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-5656121;Reactome: R-HSA-5685938;Reactome: R-HSA-174411;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-69091;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-5655862;Reactome: R-HSA-176187;Reactome: R-HSA-5693616 "Processing of DNA double-strand break ends";"Dual Incision in GG-NER";"Translesion synthesis by REV1";"Regulation of TP53 Activity through Phosphorylation";"Translesion Synthesis by POLH";"Gap-filling DNA repair synthesis and ligation in GG-NER";"G2/M DNA damage checkpoint";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Translesion synthesis by POLI";"HDR through Single Strand Annealing (SSA)";"Polymerase switching on the C-strand of the telomere";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Polymerase switching";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Translesion synthesis by POLK";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange" lcl|NW_020311513.1_prot_XP_020711406.1_9764 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311946.1_prot_XP_020712314.1_11902 1 Reactome: R-HSA-5689901 "Metalloprotease DUBs" lcl|NW_020311984.1_prot_XP_012254618.1_19909 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" lcl|NW_020311962.1_prot_XP_012251934.1_13686 2 Reactome: R-HSA-6811436;Reactome: R-HSA-8876198 "COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311972.1_prot_XP_012267865.1_16257 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" lcl|NW_020311367.1_prot_XP_012262798.1_6175 2 Reactome: R-HSA-6803157;Reactome: R-HSA-6798695 "Antimicrobial peptides";"Neutrophil degranulation" lcl|NW_020311994.1_prot_XP_012267418.1_21734 2 KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600 "Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" lcl|NW_020311965.1_prot_XP_012259866.1_14181 7 KEGG: 00280+4.1.3.4;KEGG: 00650+4.1.3.4;KEGG: 00281+4.1.3.4;Reactome: R-HSA-77111;MetaCyc: PWY-5074;KEGG: 00072+4.1.3.4;Reactome: R-HSA-9033241 "Valine, leucine and isoleucine degradation";"Butanoate metabolism";"Geraniol degradation";"Synthesis of Ketone Bodies";"Mevalonate degradation";"Synthesis and degradation of ketone bodies";"Peroxisomal protein import" lcl|NW_020311973.1_prot_XP_012258575.1_16346 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311436.1_prot_XP_012258340.1_8757 7 KEGG: 00230+3.6.1.15;MetaCyc: PWY-7184;MetaCyc: PWY-7185;MetaCyc: PWY-7210;MetaCyc: PWY-6545;MetaCyc: PWY-7198;KEGG: 00730+3.6.1.15 "Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"UTP and CTP dephosphorylation I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Thiamine metabolism" lcl|NW_020311993.1_prot_XP_020710311.1_21413 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" lcl|NW_020311940.1_prot_XP_025602346.1_11184 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311373.1_prot_XP_012266726.1_6478 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311294.1_prot_XP_012264949.1_888 6 Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72706 "Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311513.1_prot_XP_012266042.1_9772 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311980.1_prot_XP_020709755.1_18783 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311948.1_prot_XP_012253570.1_11993 12 Reactome: R-HSA-70171;MetaCyc: PWY-1861;KEGG: 00030+4.1.2.13;KEGG: 00051+4.1.2.13;MetaCyc: PWY-5484;KEGG: 00010+4.1.2.13;MetaCyc: PWY-7385;KEGG: 00680+4.1.2.13;MetaCyc: PWY-6142;KEGG: 00710+4.1.2.13;Reactome: R-HSA-70263;MetaCyc: PWY-1042 "Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis";"Glycolysis IV (plant cytosol)" lcl|NW_020311895.1_prot_XP_012251689.1_10133 3 MetaCyc: PWY-5686;Reactome: R-HSA-500753;KEGG: 00240+1.3.5.2 "UMP biosynthesis I";"Pyrimidine biosynthesis";"Pyrimidine metabolism" lcl|NW_020311397.1_prot_XP_012258204.1_7283 3 Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" lcl|NW_020311292.1_prot_XP_025601865.1_731 1 Reactome: R-HSA-5601884 "PIWI-interacting RNA (piRNA) biogenesis" lcl|NW_020311417.1_prot_XP_025602023.1_7955 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" lcl|NW_020311958.1_prot_XP_020708060.1_12987 13 Reactome: R-HSA-2871809;Reactome: R-HSA-5578775;Reactome: R-HSA-114508;Reactome: R-HSA-1489509;Reactome: R-HSA-422356;Reactome: R-HSA-2029485;Reactome: R-HSA-5607763;Reactome: R-HSA-139853;Reactome: R-HSA-381676;Reactome: R-HSA-983695;Reactome: R-HSA-4086398;Reactome: R-HSA-5218921;Reactome: R-HSA-112043 "FCERI mediated Ca+2 mobilization";"Ion homeostasis";"Effects of PIP2 hydrolysis";"DAG and IP3 signaling";"Regulation of insulin secretion";"Role of phospholipids in phagocytosis";"CLEC7A (Dectin-1) induces NFAT activation";"Elevation of cytosolic Ca2+ levels";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Ca2+ pathway";"VEGFR2 mediated cell proliferation";"PLC beta mediated events" lcl|NW_020311313.1_prot_XP_012261779.1_2933 9 Reactome: R-HSA-9617324;Reactome: R-HSA-8849932;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-438066;Reactome: R-HSA-442982;Reactome: R-HSA-9620244;Reactome: R-HSA-3928662;Reactome: R-HSA-6794361 "Negative regulation of NMDA receptor-mediated neuronal transmission";"Synaptic adhesion-like molecules";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"Unblocking of NMDA receptors, glutamate binding and activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Long-term potentiation";"EPHB-mediated forward signaling";"Neurexins and neuroligins" lcl|NW_020311380.1_prot_XP_012268191.1_6738 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311965.1_prot_XP_020709408.1_14222 13 Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72689 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits" lcl|NW_020311966.1_prot_XP_020708294.1_15195 4 Reactome: R-HSA-947581;MetaCyc: PWY-7887;MetaCyc: PWY-6823;KEGG: 00790+2.8.1.12 "Molybdenum cofactor biosynthesis";"Protein SAMPylation and SAMP-mediated thiolation";"Molybdenum cofactor biosynthesis";"Folate biosynthesis" lcl|NW_020311401.1_prot_XP_012254748.1_7460 5 Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-72163 "Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"mRNA Splicing - Major Pathway" lcl|NW_020311375.1_prot_XP_012256476.2_6556 1 Reactome: R-HSA-1296061 "HCN channels" lcl|NW_020311984.1_prot_XP_012254488.1_19927 11 Reactome: R-HSA-210990;Reactome: R-HSA-388841;Reactome: R-HSA-9008059;Reactome: R-HSA-391160;Reactome: R-HSA-432142;Reactome: R-HSA-912694;Reactome: R-HSA-114604;Reactome: R-HSA-877312;Reactome: R-HSA-512988;Reactome: R-HSA-909733;Reactome: R-HSA-389948 "PECAM1 interactions";"Costimulation by the CD28 family";"Interleukin-37 signaling";"Signal regulatory protein family interactions";"Platelet sensitization by LDL";"Regulation of IFNA signaling";"GPVI-mediated activation cascade";"Regulation of IFNG signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Interferon alpha/beta signaling";"PD-1 signaling" lcl|NW_020311985.1_prot_XP_012253975.1_20299 3 Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916 "Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium" lcl|NW_020311974.1_prot_XP_012260198.1_16934 4 Reactome: R-HSA-351202;KEGG: 00330+2.5.1.16;KEGG: 00480+2.5.1.16;KEGG: 00270+2.5.1.16 "Metabolism of polyamines";"Arginine and proline metabolism";"Glutathione metabolism";"Cysteine and methionine metabolism" lcl|NW_020311940.1_prot_XP_025602341.1_11185 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311423.1_prot_XP_012251564.1_8165 6 MetaCyc: PWY-7900;MetaCyc: PWY-622;KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067;Reactome: R-HSA-189085;KEGG: 00500+3.2.1.1 "Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch biosynthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism" lcl|NW_020311966.1_prot_XP_020708099.1_15067 8 KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7921;Reactome: R-HSA-5083633 "Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation I (yeast)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1" lcl|NW_020311311.1_prot_XP_012250771.1_2561 17 Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-176412;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-176408;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-176407;Reactome: R-HSA-174178 "APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Phosphorylation of the APC/C";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Regulation of APC/C activators between G1/S and early anaphase";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" lcl|NW_020311979.1_prot_XP_012259489.1_18570 3 MetaCyc: PWY-1801;Reactome: R-HSA-156590;KEGG: 00680+3.1.2.12 "Formaldehyde oxidation II (glutathione-dependent)";"Glutathione conjugation";"Methane metabolism" lcl|NW_020311298.1_prot_XP_020706284.1_1350 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311965.1_prot_XP_012259413.1_14357 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311978.1_prot_XP_025602792.1_18036 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" lcl|NW_020311364.1_prot_XP_020708950.1_5925 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase" lcl|NW_020311411.1_prot_XP_012259204.1_7869 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311940.1_prot_XP_012265540.1_11348 3 MetaCyc: PWY-6317;KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3 "D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Glycolysis / Gluconeogenesis" lcl|NW_020311377.1_prot_XP_012266573.1_6620 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311397.1_prot_XP_020708715.1_7290 3 Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311966.1_prot_XP_012251694.1_14568 56 Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-5668541;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-187577;Reactome: R-HSA-1236978;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-8951664;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-5610780;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5610785;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-9010553;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-8939236;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-382556;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-349425;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-5632684;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5689880;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895 "Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"TNFR2 non-canonical NF-kB pathway";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"SCF(Skp2)-mediated degradation of p27/p21";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of RAS by GAPs";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Neddylation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI1 by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of expression of SLITs and ROBOs";"Degradation of DVL";"Interleukin-1 signaling";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"ABC-family proteins mediated transport";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Hedgehog 'on' state";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Ub-specific processing proteases";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis" lcl|NW_020311965.1_prot_XP_020709362.1_14160 1 Reactome: R-HSA-71262 "Carnitine synthesis" lcl|NW_020311982.1_prot_XP_012258239.1_19258 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311305.1_prot_XP_012251487.1_2034 3 Reactome: R-HSA-1268020;Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Mitochondrial protein import";"Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311955.1_prot_XP_012265458.1_12505 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311986.1_prot_XP_012258899.1_20325 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311364.1_prot_XP_012258850.1_5905 1 Reactome: R-HSA-204626 "Hypusine synthesis from eIF5A-lysine" lcl|NW_020311994.1_prot_XP_012267471.1_21736 5 MetaCyc: PWY-7268;MetaCyc: PWY-5083;MetaCyc: PWY-7269;Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23 "NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism" lcl|NW_020311311.1_prot_XP_012250900.1_2455 6 Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-427359;Reactome: R-HSA-73772 "NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"SIRT1 negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape" lcl|NW_020311329.1_prot_XP_012258976.1_3938 4 Reactome: R-HSA-1912420;Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Pre-NOTCH Processing in Golgi";"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311917.1_prot_XP_012250987.1_10250 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311977.1_prot_XP_012264035.1_17888 6 KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733 "Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis" lcl|NW_020311434.1_prot_XP_012252203.1_8739 3 Reactome: R-HSA-1483191;Reactome: R-HSA-112311;Reactome: R-HSA-422085 "Synthesis of PC";"Neurotransmitter clearance";"Synthesis, secretion, and deacylation of Ghrelin" lcl|NW_020311286.1_prot_XP_012256271.1_91 2 Reactome: R-HSA-1799339;Reactome: R-HSA-446203 "SRP-dependent cotranslational protein targeting to membrane";"Asparagine N-linked glycosylation" lcl|NW_020311925.1_prot_XP_020708943.1_10514 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311988.1_prot_XP_012262468.1_20479 1 Reactome: R-HSA-71064 "Lysine catabolism" lcl|NW_020311441.1_prot_XP_012251243.1_8884 3 Reactome: R-HSA-189451;MetaCyc: PWY-7159;KEGG: 00860+1.3.3.4 "Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism" lcl|NW_020311373.1_prot_XP_020706524.1_6503 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" lcl|NW_020311313.1_prot_XP_020709885.1_2897 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311292.1_prot_XP_012252461.1_527 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311290.1_prot_XP_012269412.1_430 2 Reactome: R-HSA-3214847;Reactome: R-HSA-6804758 "HATs acetylate histones";"Regulation of TP53 Activity through Acetylation" lcl|NW_020311986.1_prot_XP_012258881.1_20347 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311475.1_prot_XP_012253312.1_9392 16 Reactome: R-HSA-416476;Reactome: R-HSA-512988;Reactome: R-HSA-912526;Reactome: R-HSA-912631;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-8853659;Reactome: R-HSA-9009391;Reactome: R-HSA-388841;Reactome: R-HSA-1266695;Reactome: R-HSA-1660499;Reactome: R-HSA-1433557;Reactome: R-HSA-1257604;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558;Reactome: R-HSA-389357 "G alpha (q) signalling events";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Interleukin receptor SHC signaling";"Regulation of signaling by CBL";"Rho GTPase cycle";"GPVI-mediated activation cascade";"RET signaling";"Extra-nuclear estrogen signaling";"Costimulation by the CD28 family";"Interleukin-7 signaling";"Synthesis of PIPs at the plasma membrane";"Signaling by SCF-KIT";"PIP3 activates AKT signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"CD28 dependent PI3K/Akt signaling" lcl|NW_020311978.1_prot_XP_012258013.1_18264 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311334.1_prot_XP_012265870.1_4407 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311985.1_prot_XP_012265257.1_20237 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311993.1_prot_XP_012263322.1_21366 3 Reactome: R-HSA-75109;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Triglyceride biosynthesis";"Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311940.1_prot_XP_012265630.1_11317 14 MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7411;MetaCyc: PWY-5981;MetaCyc: PWY-7589;MetaCyc: PWY-7417;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-7782;KEGG: 00561+2.3.1.51;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-5667 "Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)";"Phospholipid remodeling (phosphatidate, yeast)";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Plasmalogen biosynthesis";"Glycerolipid metabolism";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I" lcl|NW_020311985.1_prot_XP_012253979.1_20302 3 Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing" lcl|NW_020311936.1_prot_XP_012261383.1_10982 9 KEGG: 00531+3.2.1.52;KEGG: 00513+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-6902;MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52 "Glycosaminoglycan degradation";"Various types of N-glycan biosynthesis";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series" lcl|NW_020311967.1_prot_XP_012256042.1_15208 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311476.1_prot_XP_012254093.1_9420 7 Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-606279;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Deposition of new CENPA-containing nucleosomes at the centromere";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"RHO GTPases Activate Formins" lcl|NW_020311985.1_prot_XP_012265299.1_20192 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311977.1_prot_XP_012264033.1_17891 5 Reactome: R-HSA-350054;Reactome: R-HSA-5083630;Reactome: R-HSA-1912399;Reactome: R-HSA-1912420;Reactome: R-HSA-1912408 "Notch-HLH transcription pathway";"Defective LFNG causes SCDO3";"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Pre-NOTCH Processing in Golgi";"Pre-NOTCH Transcription and Translation" lcl|NW_020311932.1_prot_XP_020708468.1_10718 6 Reactome: R-HSA-194840;KEGG: 00562+3.1.3.36;Reactome: R-HSA-1855204;Reactome: R-HSA-1855183;MetaCyc: PWY-6368;KEGG: 04070+3.1.3.36 "Rho GTPase cycle";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"Synthesis of IP2, IP, and Ins in the cytosol";"3-phosphoinositide degradation";"Phosphatidylinositol signaling system" lcl|NW_020311965.1_prot_XP_012259400.1_14386 4 Reactome: R-HSA-6787450;KEGG: 00908+2.5.1.75;Reactome: R-HSA-6782315;MetaCyc: PWY-2781 "tRNA modification in the mitochondrion";"Zeatin biosynthesis";"tRNA modification in the nucleus and cytosol";"Cis-zeatin biosynthesis" lcl|NW_020311977.1_prot_XP_012263928.1_17811 14 Reactome: R-HSA-9013700;Reactome: R-HSA-2894862;Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-2644606;Reactome: R-HSA-193692;Reactome: R-HSA-9013507;Reactome: R-HSA-6798695;Reactome: R-HSA-1251985;Reactome: R-HSA-1474228;Reactome: R-HSA-977225;Reactome: R-HSA-9017802;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948 "NOTCH4 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulated proteolysis of p75NTR";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Neutrophil degranulation";"Nuclear signaling by ERBB4";"Degradation of the extracellular matrix";"Amyloid fiber formation";"Noncanonical activation of NOTCH3";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus" lcl|NW_020311513.1_prot_XP_020711409.1_9774 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311974.1_prot_XP_012259910.1_16791 10 MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.15;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7411;KEGG: 00564+2.3.1.15 "Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Phosphatidate biosynthesis (yeast)";"Glycerophospholipid metabolism" lcl|NW_020311419.1_prot_XP_020707414.1_8064 15 Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-167158;Reactome: R-HSA-9603505;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-113418 "Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of the HIV-1 Early Elongation Complex";"NTRK3 as a dependence receptor";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Formation of the Early Elongation Complex" lcl|NW_020311397.1_prot_XP_020708717.1_7285 3 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases" lcl|NW_020311342.1_prot_XP_012255777.1_4728 10 Reactome: R-HSA-1912408;Reactome: R-HSA-2197563;Reactome: R-HSA-2122947;Reactome: R-HSA-9013508;Reactome: R-HSA-8941856;Reactome: R-HSA-350054;Reactome: R-HSA-210744;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-9013695 "Pre-NOTCH Transcription and Translation";"NOTCH2 intracellular domain regulates transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH3 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Notch-HLH transcription pathway";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription" lcl|NW_020311980.1_prot_XP_012261235.1_18802 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311293.1_prot_XP_020710554.1_856 3 Reactome: R-HSA-8854691;KEGG: 04660+2.7.10.2;Reactome: R-HSA-6785807 "Interleukin-20 family signaling";"T cell receptor signaling pathway";"Interleukin-4 and Interleukin-13 signaling" lcl|NW_020311995.1_prot_XP_020708181.1_21874 16 Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-174178;Reactome: R-HSA-176407;Reactome: R-HSA-141430;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-174084;Reactome: R-HSA-983168;Reactome: R-HSA-176412;Reactome: R-HSA-179409;Reactome: R-HSA-176408 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Inactivation of APC/C via direct inhibition of the APC/C complex";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"Phosphorylation of the APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Regulation of APC/C activators between G1/S and early anaphase" lcl|NW_020311977.1_prot_XP_020710679.1_17739 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" lcl|NW_020311966.1_prot_XP_020708238.1_14730 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311948.1_prot_XP_012253652.1_12094 6 Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311407.1_prot_XP_020707682.1_7792 5 Reactome: R-HSA-380994;Reactome: R-HSA-9614657;Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-381183 "ATF4 activates genes in response to endoplasmic reticulum stress";"FOXO-mediated transcription of cell death genes";"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"ATF6 (ATF6-alpha) activates chaperone genes" lcl|NW_020311934.1_prot_XP_012254949.1_10868 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" lcl|NW_020311965.1_prot_XP_012259542.1_14318 13 Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689 "Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits" lcl|NW_020311957.1_prot_XP_012263405.1_12777 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311312.1_prot_XP_012266821.1_2766 5 Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379 "Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events" lcl|NW_020311418.1_prot_XP_012261014.1_8002 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311313.1_prot_XP_012261692.1_3033 1 Reactome: R-HSA-419771 "Opsins" lcl|NW_020311959.1_prot_XP_020709512.1_13036 2 Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" lcl|NW_020311326.1_prot_XP_012261479.1_3706 2 Reactome: R-HSA-2151201;Reactome: R-HSA-6793080 "Transcriptional activation of mitochondrial biogenesis";"rRNA modification in the mitochondrion" lcl|NW_020311994.1_prot_XP_012267460.1_21798 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311311.1_prot_XP_012250788.1_2533 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311971.1_prot_XP_012260934.1_15869 11 Reactome: R-HSA-2173796;Reactome: R-HSA-2644606;Reactome: R-HSA-72163;Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-1912408;Reactome: R-HSA-2122947;Reactome: R-HSA-8941856;Reactome: R-HSA-210744;Reactome: R-HSA-350054;Reactome: R-HSA-9013508 "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"mRNA Splicing - Major Pathway";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"NOTCH1 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Notch-HLH transcription pathway";"NOTCH3 Intracellular Domain Regulates Transcription" lcl|NW_020311969.1_prot_XP_020710967.1_15562 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection" lcl|NW_020311934.1_prot_XP_012255037.1_10863 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311308.1_prot_XP_020710837.1_2183 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311397.1_prot_XP_012258211.1_7305 4 Reactome: R-HSA-9613829;Reactome: R-HSA-3899300;Reactome: R-HSA-9615710;Reactome: R-HSA-9646399 "Chaperone Mediated Autophagy";"SUMOylation of transcription cofactors";"Late endosomal microautophagy";"Aggrephagy" lcl|NW_020311373.1_prot_XP_012266672.1_6440 14 Reactome: R-HSA-5656169;Reactome: R-HSA-5651801;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-5685942;Reactome: R-HSA-5656121;Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-5696397;Reactome: R-HSA-110320;Reactome: R-HSA-110314;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-5655862 "Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by POLI";"Dual Incision in GG-NER";"Polymerase switching";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion Synthesis by POLH";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Translesion synthesis by POLK" lcl|NW_020311292.1_prot_XP_012252511.1_581 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311980.1_prot_XP_012261368.1_18759 2 Reactome: R-HSA-2022854;Reactome: R-HSA-975577 "Keratan sulfate biosynthesis";"N-Glycan antennae elongation" lcl|NW_020311984.1_prot_XP_012267720.1_20113 8 Reactome: R-HSA-69166;Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-174411;Reactome: R-HSA-174430;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-113501 "Removal of the Flap Intermediate";"Polymerase switching";"DNA replication initiation";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand synthesis initiation";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Inhibition of replication initiation of damaged DNA by RB1/E2F1" lcl|NW_020311419.1_prot_XP_012254039.1_8090 13 MetaCyc: PWY-7227;MetaCyc: PWY-7226;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7222;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7220;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7184;KEGG: 00983+1.17.4.1 "Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes" lcl|NW_020311959.1_prot_XP_012262383.1_13123 2 KEGG: 00280+1.1.1.31;Reactome: R-HSA-70895 "Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism" lcl|NW_020311982.1_prot_XP_025602867.1_19379 2 KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085 "Starch and sucrose metabolism";"Digestion of dietary carbohydrate" lcl|NW_020311386.1_prot_XP_012268142.1_6927 7 Reactome: R-HSA-6798695;KEGG: 00230+2.4.2.7;Reactome: R-HSA-74217;MetaCyc: PWY-6610;MetaCyc: PWY-6605;MetaCyc: PWY-7805;MetaCyc: PWY-7807 "Neutrophil degranulation";"Purine metabolism";"Purine salvage";"Adenine salvage";"Adenine and adenosine salvage II";"(aminomethyl)phosphonate degradation";"Glyphosate degradation III" lcl|NW_020311418.1_prot_XP_012261064.1_8050 2 Reactome: R-HSA-416476;Reactome: R-HSA-375276 "G alpha (q) signalling events";"Peptide ligand-binding receptors" lcl|NW_020311934.1_prot_XP_012255136.1_10811 2 KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386 "Pyruvate metabolism";"Methylglyoxal degradation I" lcl|NW_020311917.1_prot_XP_012250927.1_10202 19 Reactome: R-HSA-8964026;Reactome: R-HSA-8963888;Reactome: R-HSA-8856828;Reactome: R-HSA-8866423;Reactome: R-HSA-8856825;Reactome: R-HSA-3000480;Reactome: R-HSA-8964046;Reactome: R-HSA-8957275;Reactome: R-HSA-8964041;Reactome: R-HSA-202733;Reactome: R-HSA-8964038;Reactome: R-HSA-8963901;Reactome: R-HSA-975634;Reactome: R-HSA-432142;Reactome: R-HSA-3000471;Reactome: R-HSA-381426;Reactome: R-HSA-5686938;Reactome: R-HSA-3000497;Reactome: R-HSA-3000484 "Chylomicron clearance";"Chylomicron assembly";"Clathrin-mediated endocytosis";"VLDL assembly";"Cargo recognition for clathrin-mediated endocytosis";"Scavenging by Class A Receptors";"VLDL clearance";"Post-translational protein phosphorylation";"LDL remodeling";"Cell surface interactions at the vascular wall";"LDL clearance";"Chylomicron remodeling";"Retinoid metabolism and transport";"Platelet sensitization by LDL";"Scavenging by Class B Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Regulation of TLR by endogenous ligand";"Scavenging by Class H Receptors";"Scavenging by Class F Receptors" lcl|NW_020311974.1_prot_XP_012259880.1_16899 1 MetaCyc: PWY-7437 "Protein O-[N-acetyl]-glucosylation" lcl|NW_020311917.1_prot_XP_020706419.1_10226 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311417.1_prot_XP_025602032.1_7954 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" lcl|NW_020311976.1_prot_XP_012257262.1_17419 1 Reactome: R-HSA-5693565 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" lcl|NW_020311407.1_prot_XP_020707774.1_7785 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311423.1_prot_XP_020706609.1_8174 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311324.1_prot_XP_012269430.1_3581 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311309.1_prot_XP_012259134.1_2369 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311966.1_prot_XP_012256651.1_14691 1 KEGG: 00450+1.8.1.9 "Selenocompound metabolism" lcl|NW_020311311.1_prot_XP_020706389.1_2469 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311957.1_prot_XP_012261023.1_12678 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311984.1_prot_XP_012264706.1_19829 6 MetaCyc: PWY-922;Reactome: R-HSA-446199;Reactome: R-HSA-2426168;Reactome: R-HSA-191273;KEGG: 00900+4.1.1.33;MetaCyc: PWY-7391 "Mevalonate pathway I";"Synthesis of Dolichyl-phosphate";"Activation of gene expression by SREBF (SREBP)";"Cholesterol biosynthesis";"Terpenoid backbone biosynthesis";"Isoprene biosynthesis II (engineered)" lcl|NW_020311994.1_prot_XP_012267589.1_21764 9 KEGG: 04070+3.1.4.11;Reactome: R-HSA-1855204;Reactome: R-HSA-416476;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;Reactome: R-HSA-112043;MetaCyc: PWY-6351;MetaCyc: PWY-8052;MetaCyc: PWY-6367 "Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol";"G alpha (q) signalling events";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"PLC beta mediated events";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"2-arachidonoylglycerol biosynthesis";"D-myo-inositol-5-phosphate metabolism" lcl|NW_020311294.1_prot_XP_020711018.1_870 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" lcl|NW_020311982.1_prot_XP_020708768.1_19273 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311978.1_prot_XP_020708664.1_18255 3 Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878 "Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport" lcl|NW_020311300.1_prot_XP_012253165.1_1529 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311983.1_prot_XP_012267221.1_19500 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" lcl|NW_020311380.1_prot_XP_012268188.1_6736 3 KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154 "Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase" lcl|NW_020311397.1_prot_XP_012253743.1_7337 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311513.1_prot_XP_012266164.1_9810 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" lcl|NW_020311450.1_prot_XP_012260301.1_9034 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" lcl|NW_020311973.1_prot_XP_012258734.1_16331 29 Reactome: R-HSA-6781827;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-167172;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-6782135;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-6782210;Reactome: R-HSA-167161;Reactome: R-HSA-5696400;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-6796648;Reactome: R-HSA-73863 "Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"mRNA Capping";"Transcription of the HIV genome";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"Dual incision in TC-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HIV Transcription Initiation";"Dual Incision in GG-NER";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination" lcl|NW_020311995.1_prot_XP_012256347.1_21873 16 Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-176408;Reactome: R-HSA-179409 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of APC/C activators between G1/S and early anaphase";"APC-Cdc20 mediated degradation of Nek2A" lcl|NW_020311367.1_prot_XP_012258951.1_6089 2 MetaCyc: PWY-6502;Reactome: R-HSA-2393930 "8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins" lcl|NW_020311978.1_prot_XP_020708585.1_18040 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311967.1_prot_XP_012254284.1_15279 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311982.1_prot_XP_012258371.1_19208 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" lcl|NW_020311957.1_prot_XP_012263329.1_12845 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311348.1_prot_XP_012269822.1_5115 1 Reactome: R-HSA-5419276 "Mitochondrial translation termination" lcl|NW_020311978.1_prot_XP_020708674.1_18128 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311966.1_prot_XP_012252936.1_14418 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311423.1_prot_XP_012251577.1_8156 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311962.1_prot_XP_012252070.1_13693 1 Reactome: R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" lcl|NW_020311956.1_prot_XP_012254591.1_12584 4 Reactome: R-HSA-983189;Reactome: R-HSA-5625970;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434 "Kinesins";"RHO GTPases activate KTN1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311513.1_prot_XP_012266036.1_9768 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311972.1_prot_XP_012267926.1_16270 5 MetaCyc: PWY-5514;KEGG: 00520+3.5.99.6;Reactome: R-HSA-70171;MetaCyc: PWY-6855;MetaCyc: PWY-6906 "UDP-N-acetyl-D-galactosamine biosynthesis II";"Amino sugar and nucleotide sugar metabolism";"Glycolysis";"Chitin degradation I (archaea)";"Chitin derivatives degradation" lcl|NW_020311994.1_prot_XP_012267405.1_21572 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" lcl|NW_020311365.1_prot_XP_020712490.1_5986 17 Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-6790901;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"rRNA modification in the nucleus and cytosol";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits" lcl|NW_020311292.1_prot_XP_020710269.1_696 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-112308 "NCAM1 interactions";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening" lcl|NW_020311388.1_prot_XP_012262196.1_6952 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311311.1_prot_XP_012250852.1_2573 7 Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-9639288 "TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of PTEN gene transcription";"mTOR signalling";"Amino acids regulate mTORC1" lcl|NW_020311612.1_prot_XP_012255463.2_10071 1 KEGG: 00920+1.14.14.5 "Sulfur metabolism" lcl|NW_020311975.1_prot_XP_012250902.1_17054 2 Reactome: R-HSA-196741;Reactome: R-HSA-3359473 "Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD" lcl|NW_020311971.1_prot_XP_012263543.1_16090 12 Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436 "Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311977.1_prot_XP_020710683.1_17727 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311381.1_prot_XP_012252333.1_6832 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311325.1_prot_XP_012253357.1_3690 4 KEGG: 00983+2.7.1.48;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193;Reactome: R-HSA-73614 "Drug metabolism - other enzymes";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I";"Pyrimidine salvage" lcl|NW_020311436.1_prot_XP_025602103.1_8796 4 Reactome: R-HSA-4655427;Reactome: R-HSA-5334118;Reactome: R-HSA-212300;KEGG: 00270+2.1.1.37 "SUMOylation of DNA methylation proteins";"DNA methylation";"PRC2 methylates histones and DNA";"Cysteine and methionine metabolism" lcl|NW_020311975.1_prot_XP_012250912.1_17055 2 Reactome: R-HSA-3359473;Reactome: R-HSA-196741 "Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD";"Cobalamin (Cbl, vitamin B12) transport and metabolism" lcl|NW_020311907.1_prot_XP_012264883.1_10147 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311970.1_prot_XP_012267435.1_15810 5 Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556 "Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes" lcl|NW_020311424.1_prot_XP_012255412.1_8198 2 Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" lcl|NW_020311961.1_prot_XP_012262729.1_13332 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311382.1_prot_XP_012268013.1_6856 8 MetaCyc: PWY-7391;Reactome: R-HSA-191273;Reactome: R-HSA-2426168;MetaCyc: PWY-922;KEGG: 00900+1.1.1.34;Reactome: R-HSA-1989781;MetaCyc: PWY-7524;MetaCyc: PWY-6174 "Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"PPARA activates gene expression";"Mevalonate pathway III (archaea)";"Mevalonate pathway II (archaea)" lcl|NW_020311472.1_prot_XP_020712469.1_9371 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" lcl|NW_020311978.1_prot_XP_012257945.1_18347 20 MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7291;MetaCyc: PWY-7337;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7858;MetaCyc: PWY-7726;MetaCyc: PWY-7340;MetaCyc: PWY-6920;MetaCyc: PWY-7288;Reactome: R-HSA-9033241;MetaCyc: PWY-735;MetaCyc: PWY-7007;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7574;MetaCyc: PWY-7338;MetaCyc: PWY-7854;MetaCyc: PWY-7606 "Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"alpha-Linolenic acid metabolism";"Oleate beta-oxidation (isomerase-dependent, yeast)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"beta-Alanine metabolism";"(5Z)-dodecenoate biosynthesis II";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Peroxisomal protein import";"Jasmonic acid biosynthesis";"Methyl ketone biosynthesis (engineered)";"Propanoate metabolism";"Propanoyl-coa degradation II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)" lcl|NW_020311298.1_prot_XP_012250596.1_1164 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311973.1_prot_XP_012258543.1_16497 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" lcl|NW_020311513.1_prot_XP_012266221.1_9908 1 Reactome: R-HSA-72165 "mRNA Splicing - Minor Pathway" lcl|NW_020311993.1_prot_XP_012262649.1_21373 1 Reactome: R-HSA-611105 "Respiratory electron transport" lcl|NW_020311401.1_prot_XP_012254995.1_7501 8 Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-432040;Reactome: R-HSA-983231;Reactome: R-HSA-164378;Reactome: R-HSA-180024;Reactome: R-HSA-442720;Reactome: R-HSA-381676 "PKA activation";"Hedgehog 'off' state";"Vasopressin regulates renal water homeostasis via Aquaporins";"Factors involved in megakaryocyte development and platelet production";"PKA activation in glucagon signalling";"DARPP-32 events";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion" lcl|NW_020311956.1_prot_XP_012251515.1_12615 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311994.1_prot_XP_020711902.1_21741 5 MetaCyc: PWY-5083;MetaCyc: PWY-7268;MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807 "NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism" lcl|NW_020311965.1_prot_XP_012260339.1_14154 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311962.1_prot_XP_025602503.1_13746 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311448.1_prot_XP_025602126.1_9013 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311348.1_prot_XP_012269817.1_5111 6 MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656 "Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311983.1_prot_XP_012268274.2_19603 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311992.1_prot_XP_012266477.1_21271 4 KEGG: 00270+2.5.1.6;Reactome: R-HSA-156581;MetaCyc: PWY-5912;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"Methylation";"2'-deoxymugineic acid phytosiderophore biosynthesis";"S-adenosyl-L-methionine cycle II" lcl|NW_020311961.1_prot_XP_020710232.1_13252 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311365.1_prot_XP_020712484.1_5998 4 Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" lcl|NW_020311971.1_prot_XP_012263516.1_16097 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311294.1_prot_XP_020711008.1_883 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" lcl|NW_020311432.1_prot_XP_012268927.1_8561 2 Reactome: R-HSA-418594;Reactome: R-HSA-6814122 "G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" lcl|NW_020311332.1_prot_XP_012268565.1_4119 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311507.1_prot_XP_012259688.1_9628 11 Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-163615 "Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"G alpha (s) signalling events";"G alpha (z) signalling events";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase activating pathway";"PKA activation" lcl|NW_020311424.1_prot_XP_012255389.1_8197 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311300.1_prot_XP_025602596.1_1508 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311396.1_prot_XP_012269613.1_7256 3 Reactome: R-HSA-8876198;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" lcl|NW_020311321.1_prot_XP_012263212.1_3403 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311978.1_prot_XP_012257897.1_18345 3 MetaCyc: PWY-7174;MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23 "S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism" lcl|NW_020311981.1_prot_XP_012257351.1_19064 2 Reactome: R-HSA-6784531;Reactome: R-HSA-6785470 "tRNA processing in the nucleus";"tRNA processing in the mitochondrion" lcl|NW_020311969.1_prot_XP_012264789.1_15543 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311978.1_prot_XP_020708671.1_18124 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311355.1_prot_XP_025601850.1_5499 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311308.1_prot_XP_020710838.1_2179 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311298.1_prot_XP_020706285.1_1351 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311380.1_prot_XP_012261404.1_6689 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311985.1_prot_XP_012265226.1_20230 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311958.1_prot_XP_025602456.1_12910 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311339.1_prot_XP_012254192.1_4612 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311337.1_prot_XP_012251794.1_4434 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311993.1_prot_XP_020710489.1_21381 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311984.1_prot_XP_020707619.1_20014 1 Reactome: R-HSA-400253 "Circadian Clock" lcl|NW_020311993.1_prot_XP_020710387.1_21405 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" lcl|NW_020311309.1_prot_XP_012259131.1_2368 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311990.1_prot_XP_012266457.1_20855 2 KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1 "Purine metabolism";"Pentose phosphate pathway" lcl|NW_020311959.1_prot_XP_012254242.1_13205 1 Reactome: R-HSA-197264 "Nicotinamide salvaging" lcl|NW_020311966.1_prot_XP_020708101.1_15069 8 MetaCyc: PWY-7979;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;KEGG: 00515+2.4.1.109 "Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Mannose type O-glycan biosynthesis" lcl|NW_020311979.1_prot_XP_012259492.1_18559 1 Reactome: R-HSA-5676934 "Protein repair" lcl|NW_020311961.1_prot_XP_012262626.1_13301 1 Reactome: R-HSA-1483166 "Synthesis of PA" lcl|NW_020311432.1_prot_XP_012268828.1_8566 8 Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68616;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68827;Reactome: R-HSA-68689;Reactome: R-HSA-113507 "Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"CDT1 association with the CDC6:ORC:origin complex";"CDC6 association with the ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation" lcl|NW_020311388.1_prot_XP_012264759.1_6965 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311396.1_prot_XP_012269516.1_7266 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311320.1_prot_XP_012267762.1_3364 1 Reactome: R-HSA-1362409 "Mitochondrial iron-sulfur cluster biogenesis" lcl|NW_020311453.1_prot_XP_012252718.1_9077 2 Reactome: R-HSA-9603798;Reactome: R-HSA-1369062 "Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis" lcl|NW_020311992.1_prot_XP_012266287.1_21030 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311304.1_prot_XP_012260616.1_1799 6 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311943.1_prot_XP_020707703.1_11636 3 KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00250+3.5.1.1 "Cyanoamino acid metabolism";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311974.1_prot_XP_020709331.1_16711 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311955.1_prot_XP_012265408.1_12388 10 MetaCyc: PWY-6317;Reactome: R-HSA-5609977;MetaCyc: PWY-6527;MetaCyc: PWY-6397;MetaCyc: PWY-3821;Reactome: R-HSA-70370;MetaCyc: PWY-7328;MetaCyc: PWY-7344;KEGG: 00052+5.1.3.2;KEGG: 00520+5.1.3.2 "D-galactose degradation I (Leloir pathway)";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Stachyose degradation";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose detoxification";"Galactose catabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"UDP-alpha-D-galactose biosynthesis";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311296.1_prot_XP_012262831.1_1062 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311958.1_prot_XP_020708047.1_12990 13 Reactome: R-HSA-139853;Reactome: R-HSA-381676;Reactome: R-HSA-983695;Reactome: R-HSA-4086398;Reactome: R-HSA-5218921;Reactome: R-HSA-112043;Reactome: R-HSA-2871809;Reactome: R-HSA-5578775;Reactome: R-HSA-114508;Reactome: R-HSA-1489509;Reactome: R-HSA-422356;Reactome: R-HSA-2029485;Reactome: R-HSA-5607763 "Elevation of cytosolic Ca2+ levels";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Ca2+ pathway";"VEGFR2 mediated cell proliferation";"PLC beta mediated events";"FCERI mediated Ca+2 mobilization";"Ion homeostasis";"Effects of PIP2 hydrolysis";"DAG and IP3 signaling";"Regulation of insulin secretion";"Role of phospholipids in phagocytosis";"CLEC7A (Dectin-1) induces NFAT activation" lcl|NW_020311392.1_prot_XP_012250954.1_7081 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311292.1_prot_XP_012252473.1_499 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" lcl|NW_020311327.1_prot_XP_020706969.1_3802 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311298.1_prot_XP_012250585.1_1222 3 Reactome: R-HSA-202427;Reactome: R-HSA-6798695;Reactome: R-HSA-6807004 "Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation";"Negative regulation of MET activity" lcl|NW_020311511.1_prot_XP_012250948.1_9672 6 Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311465.1_prot_XP_012268974.1_9246 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311972.1_prot_XP_025602681.1_16280 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311306.1_prot_XP_012264233.1_2084 9 MetaCyc: PWY-5663;MetaCyc: PWY-5664;KEGG: 00790+3.5.4.16;MetaCyc: PWY-7442;Reactome: R-HSA-1474151;MetaCyc: PWY-6983;MetaCyc: PWY-7852;MetaCyc: PWY-6147;MetaCyc: PWY-6703 "Erythro-tetrahydrobiopterin biosynthesis I";"Erythro-tetrahydrobiopterin biosynthesis II";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Threo-tetrahydrobiopterin biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Preq0 biosynthesis" lcl|NW_020311978.1_prot_XP_012257905.1_18293 12 Reactome: R-HSA-210744;Reactome: R-HSA-8941856;Reactome: R-HSA-350054;Reactome: R-HSA-3214847;Reactome: R-HSA-9013508;Reactome: R-HSA-1912408;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"RUNX3 regulates NOTCH signaling";"Notch-HLH transcription pathway";"HATs acetylate histones";"NOTCH3 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" lcl|NW_020311313.1_prot_XP_012261886.1_2875 2 Reactome: R-HSA-446199;Reactome: R-HSA-4755609 "Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59" lcl|NW_020311472.1_prot_XP_025602155.1_9337 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" lcl|NW_020311313.1_prot_XP_012261921.1_3041 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311368.1_prot_XP_012264443.1_6195 19 Reactome: R-HSA-5578775;Reactome: R-HSA-5673000;Reactome: R-HSA-3371571;Reactome: R-HSA-936837;Reactome: R-HSA-5576892;Reactome: R-HSA-9649948;Reactome: R-HSA-111932;Reactome: R-HSA-6802952;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-442982;Reactome: R-HSA-6802955;Reactome: R-HSA-399719;Reactome: R-HSA-9022692;Reactome: R-HSA-877300;Reactome: R-HSA-9620244;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-6802946 "Ion homeostasis";"RAF activation";"HSF1-dependent transactivation";"Ion transport by P-type ATPases";"Phase 0 - rapid depolarisation";"Signaling downstream of RAS mutants";"CaMK IV-mediated phosphorylation of CREB";"Signaling by BRAF and RAF fusions";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Trafficking of AMPA receptors";"Regulation of MECP2 expression and activity";"Interferon gamma signaling";"Long-term potentiation";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"Signaling by moderate kinase activity BRAF mutants" lcl|NW_020311983.1_prot_XP_012255594.1_19668 2 Reactome: R-HSA-2142691;Reactome: R-HSA-2142700 "Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)" lcl|NW_020311439.1_prot_XP_012264161.1_8831 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311441.1_prot_XP_012251246.1_8892 3 Reactome: R-HSA-189451;KEGG: 00860+1.3.3.4;MetaCyc: PWY-7159 "Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)" lcl|NW_020311976.1_prot_XP_012253586.1_17237 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.20 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311432.1_prot_XP_020712195.1_8478 6 Reactome: R-HSA-434316;Reactome: R-HSA-456926;Reactome: R-HSA-416476;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-399997 "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (q) signalling events";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Acetylcholine regulates insulin secretion" lcl|NW_020311987.1_prot_XP_012257111.1_20384 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" lcl|NW_020311965.1_prot_XP_012259806.1_14199 11 MetaCyc: PWY-7586;MetaCyc: PWY-5659;KEGG: 00520+5.3.1.8;Reactome: R-HSA-4043916;MetaCyc: PWY-3881;Reactome: R-HSA-446205;KEGG: 00051+5.3.1.8;MetaCyc: PWY-3861;MetaCyc: PWY-882;MetaCyc: PWY-7456;MetaCyc: PWY-6992 "Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"GDP-mannose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Defective MPI causes MPI-CDG (CDG-1b)";"Mannitol biosynthesis";"Synthesis of GDP-mannose";"Fructose and mannose metabolism";"Mannitol degradation II";"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-(1,4)-mannan degradation";"1,5-anhydrofructose degradation" lcl|NW_020311971.1_prot_XP_025602661.1_15853 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311327.1_prot_XP_012252881.1_3776 2 Reactome: R-HSA-446203;Reactome: R-HSA-1799339 "Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311298.1_prot_XP_012269937.1_1193 5 MetaCyc: PWY-6121;KEGG: 00230+6.3.5.3;Reactome: R-HSA-73817;MetaCyc: PWY-6277;MetaCyc: PWY-6122 "5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II" lcl|NW_020311306.1_prot_XP_012265892.1_2145 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" lcl|NW_020311953.1_prot_XP_012260483.1_12287 7 Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-73980;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-73780 "RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Chain Elongation" lcl|NW_020311975.1_prot_XP_020706564.1_17057 4 Reactome: R-HSA-196757;KEGG: 00670+1.5.1.6;KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9 "Metabolism of folate and pterines";"One carbon pool by folate";"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate" lcl|NW_020311971.1_prot_XP_020710515.1_16049 4 Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-68884;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Mitotic Telophase/Cytokinesis";"Kinesins" lcl|NW_020311298.1_prot_XP_012269862.1_1316 1 KEGG: 00970+6.1.1.16 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311918.1_prot_XP_012265040.1_10470 6 KEGG: 00760+6.3.5.1;MetaCyc: PWY-7761;MetaCyc: PWY-5381;KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807;MetaCyc: PWY-5653 "Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde" lcl|NW_020311940.1_prot_XP_020711244.1_11338 5 Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-389357;Reactome: R-HSA-1257604 "Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling" lcl|NW_020311973.1_prot_XP_012258623.1_16481 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" lcl|NW_020311408.1_prot_XP_020710014.1_7803 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311977.1_prot_XP_012263706.1_17645 1 Reactome: R-HSA-427652 "Sodium-coupled phosphate cotransporters" lcl|NW_020311981.1_prot_XP_012257359.1_19146 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311985.1_prot_XP_020711133.1_20220 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311373.1_prot_XP_012266705.1_6464 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311368.1_prot_XP_020710818.1_6192 19 Reactome: R-HSA-6802946;Reactome: R-HSA-5673001;Reactome: R-HSA-9609736;Reactome: R-HSA-438066;Reactome: R-HSA-442982;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692;Reactome: R-HSA-399719;Reactome: R-HSA-877300;Reactome: R-HSA-9620244;Reactome: R-HSA-9617324;Reactome: R-HSA-6802952;Reactome: R-HSA-5576892;Reactome: R-HSA-9649948;Reactome: R-HSA-111932;Reactome: R-HSA-3371571;Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-5673000 "Signaling by moderate kinase activity BRAF mutants";"RAF/MAP kinase cascade";"Assembly and cell surface presentation of NMDA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity";"Trafficking of AMPA receptors";"Interferon gamma signaling";"Long-term potentiation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by BRAF and RAF fusions";"Phase 0 - rapid depolarisation";"Signaling downstream of RAS mutants";"CaMK IV-mediated phosphorylation of CREB";"HSF1-dependent transactivation";"Ion transport by P-type ATPases";"Ion homeostasis";"RAF activation" lcl|NW_020311976.1_prot_XP_012253541.1_17269 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311992.1_prot_XP_012266545.1_21009 1 Reactome: R-HSA-71288 "Creatine metabolism" lcl|NW_020311408.1_prot_XP_020710015.1_7802 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311539.1_prot_XP_012262224.1_10016 3 Reactome: R-HSA-110331;Reactome: R-HSA-110357;Reactome: R-HSA-110330 "Cleavage of the damaged purine";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected purine" lcl|NW_020311286.1_prot_XP_025602264.1_79 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311312.1_prot_XP_012266818.1_2764 5 Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379 "Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events" lcl|NW_020311513.1_prot_XP_012266062.1_9827 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311973.1_prot_XP_020708893.1_16589 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311338.1_prot_XP_020710337.1_4586 2 Reactome: R-HSA-2299718;Reactome: R-HSA-2514853 "Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes" lcl|NW_020311349.1_prot_XP_012251173.1_5231 7 KEGG: 00250+3.5.1.2;Reactome: R-HSA-210500;KEGG: 00471+3.5.1.2;Reactome: R-HSA-5628897;Reactome: R-HSA-8964539;KEGG: 00220+3.5.1.2;MetaCyc: PWY-5921 "Alanine, aspartate and glutamate metabolism";"Glutamate Neurotransmitter Release Cycle";"D-Glutamine and D-glutamate metabolism";"TP53 Regulates Metabolic Genes";"Glutamate and glutamine metabolism";"Arginine biosynthesis";"Glutaminyl-trnagln biosynthesis via transamidation" lcl|NW_020311393.1_prot_XP_020711299.1_7203 10 KEGG: 00051+2.7.1.11;KEGG: 00010+2.7.1.11;MetaCyc: PWY-1042;MetaCyc: PWY-1861;Reactome: R-HSA-70171;MetaCyc: PWY-5484;KEGG: 00030+2.7.1.11;KEGG: 00052+2.7.1.11;MetaCyc: PWY-7385;KEGG: 00680+2.7.1.11 "Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Galactose metabolism";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism" lcl|NW_020311938.1_prot_XP_012250714.1_11046 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" lcl|NW_020311984.1_prot_XP_012254451.1_20036 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311994.1_prot_XP_025603023.1_21514 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311940.1_prot_XP_020711243.1_11337 5 Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757 "Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation" lcl|NW_020311472.1_prot_XP_012269260.1_9374 2 Reactome: R-HSA-8866654;MetaCyc: PWY-7511 "E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination" lcl|NW_020311917.1_prot_XP_012250977.1_10253 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311962.1_prot_XP_012251853.1_13599 5 Reactome: R-HSA-8963693;Reactome: R-HSA-9648895;Reactome: R-HSA-380994;Reactome: R-HSA-9633012;KEGG: 00250+6.3.5.4 "Aspartate and asparagine metabolism";"Response of EIF2AK1 (HRI) to heme deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Alanine, aspartate and glutamate metabolism" lcl|NW_020311972.1_prot_XP_020710979.1_16288 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311411.1_prot_XP_012252190.1_7862 1 Reactome: R-HSA-912446 "Meiotic recombination" lcl|NW_020311425.1_prot_XP_012265058.1_8242 3 Reactome: R-HSA-6807004;Reactome: R-HSA-6798695;Reactome: R-HSA-202427 "Negative regulation of MET activity";"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains" lcl|NW_020311988.1_prot_XP_012268571.1_20584 1 Reactome: R-HSA-9022692 "Regulation of MECP2 expression and activity" lcl|NW_020311984.1_prot_XP_012267664.1_20146 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311313.1_prot_XP_012261962.1_2951 1 Reactome: R-HSA-2564830 "Cytosolic iron-sulfur cluster assembly" lcl|NW_020311988.1_prot_XP_012260926.1_20559 5 KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084 "Lysine degradation";"Tryptophan metabolism";"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA" lcl|NW_020311432.1_prot_XP_012268697.1_8403 8 KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Human papillomavirus infection";"Activation of RAC1";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway" lcl|NW_020311966.1_prot_XP_012256631.1_14968 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311965.1_prot_XP_012260252.1_14130 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311962.1_prot_XP_012251964.1_13770 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311967.1_prot_XP_012254316.1_15275 2 Reactome: R-HSA-381038;Reactome: R-HSA-1799339 "XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311966.1_prot_XP_012256883.1_15174 1 Reactome: R-HSA-112308 "Presynaptic depolarization and calcium channel opening" lcl|NW_020311513.1_prot_XP_020711407.1_9765 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311993.1_prot_XP_012263232.1_21349 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311309.1_prot_XP_020709071.1_2394 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311985.1_prot_XP_020711084.2_20202 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311298.1_prot_XP_012269897.1_1231 5 KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00052+3.2.1.22 "Glycerolipid metabolism";"Stachyose degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Galactose metabolism" lcl|NW_020311286.1_prot_XP_012256561.1_157 7 MetaCyc: PWY-6922;MetaCyc: PWY-31;Reactome: R-HSA-70635;MetaCyc: PWY-4984;MetaCyc: PWY-46;KEGG: 00330+3.5.3.1;KEGG: 00220+3.5.3.1 "L-Ndelta-acetylornithine biosynthesis";"Canavanine degradation";"Urea cycle";"Urea cycle";"Putrescine biosynthesis III";"Arginine and proline metabolism";"Arginine biosynthesis" lcl|NW_020311382.1_prot_XP_020712027.1_6869 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311966.1_prot_XP_020708426.1_14628 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311333.1_prot_XP_012256001.1_4277 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311973.1_prot_XP_012258592.1_16364 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311418.1_prot_XP_012261033.1_7987 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311918.1_prot_XP_012265076.1_10441 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" lcl|NW_020311993.1_prot_XP_025602986.1_21453 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311342.1_prot_XP_012255779.1_4729 10 Reactome: R-HSA-9013695;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-210744;Reactome: R-HSA-350054;Reactome: R-HSA-8941856;Reactome: R-HSA-9013508;Reactome: R-HSA-2122947;Reactome: R-HSA-2197563;Reactome: R-HSA-1912408 "NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Notch-HLH transcription pathway";"RUNX3 regulates NOTCH signaling";"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"Pre-NOTCH Transcription and Translation" lcl|NW_020311969.1_prot_XP_020710971.1_15565 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311298.1_prot_XP_020706241.1_1168 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311991.1_prot_XP_012269775.1_20873 4 KEGG: 00330+1.5.5.2;Reactome: R-HSA-70688;MetaCyc: PWY-6922;MetaCyc: PWY-5737 "Arginine and proline metabolism";"Proline catabolism";"L-Ndelta-acetylornithine biosynthesis";"(5R)-carbapenem carboxylate biosynthesis" lcl|NW_020311934.1_prot_XP_012254844.1_10876 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6784531 "Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus" lcl|NW_020311971.1_prot_XP_012260845.1_15895 3 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" lcl|NW_020311959.1_prot_XP_012254232.1_13209 1 Reactome: R-HSA-525793 "Myogenesis" lcl|NW_020311365.1_prot_XP_012269475.1_6037 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311331.1_prot_XP_012264263.1_4099 5 Reactome: R-HSA-8866654;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-201722 "E3 ubiquitin ligases ubiquitinate target proteins";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of the beta-catenin:TCF transactivating complex" lcl|NW_020311984.1_prot_XP_012254534.1_19885 13 KEGG: 00531+3.2.1.52;KEGG: 00513+3.2.1.52;Reactome: R-HSA-1660662;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;MetaCyc: PWY-7822;Reactome: R-HSA-2022857;MetaCyc: PWY-6902;Reactome: R-HSA-2160916;MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52 "Glycosaminoglycan degradation";"Various types of N-glycan biosynthesis";"Glycosphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"Chitin degradation III (Serratia)";"Keratan sulfate degradation";"Chitin degradation II (Vibrio)";"Hyaluronan uptake and degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series" lcl|NW_020311418.1_prot_XP_012261044.1_7991 52 Reactome: R-HSA-167158;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-112382;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-76066;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-72163;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-76042;Reactome: R-HSA-167242;Reactome: R-HSA-6807505;Reactome: R-HSA-76061;Reactome: R-HSA-73863;Reactome: R-HSA-6796648;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-73772;Reactome: R-HSA-77075;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-8851708;Reactome: R-HSA-674695;Reactome: R-HSA-72165;Reactome: R-HSA-167161;Reactome: R-HSA-203927;Reactome: R-HSA-73779;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-5601884;Reactome: R-HSA-6803529;Reactome: R-HSA-6781827;Reactome: R-HSA-75955;Reactome: R-HSA-76071;Reactome: R-HSA-72086;Reactome: R-HSA-73980;Reactome: R-HSA-73776;Reactome: R-HSA-167238;Reactome: R-HSA-167162;Reactome: R-HSA-5578749;Reactome: R-HSA-749476;Reactome: R-HSA-167243;Reactome: R-HSA-5617472;Reactome: R-HSA-167287;Reactome: R-HSA-73780;Reactome: R-HSA-5250924;Reactome: R-HSA-1834949 "Formation of the HIV-1 Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of RNA Pol II elongation complex";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA Splicing - Major Pathway";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase I Transcription Termination";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase I Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Pre-transcription Events";"mRNA Splicing - Minor Pathway";"HIV Transcription Initiation";"MicroRNA (miRNA) biogenesis";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"PIWI-interacting RNA (piRNA) biogenesis";"FGFR2 alternative splicing";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II Transcription Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"mRNA Capping";"RNA Polymerase III Transcription Termination";"RNA Polymerase II Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II HIV Promoter Escape";"Transcriptional regulation by small RNAs";"RNA Polymerase III Abortive And Retractive Initiation";"Tat-mediated HIV elongation arrest and recovery";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HIV elongation arrest and recovery";"RNA Polymerase III Chain Elongation";"B-WICH complex positively regulates rRNA expression";"Cytosolic sensors of pathogen-associated DNA" lcl|NW_020311988.1_prot_XP_020709723.1_20695 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" lcl|NW_020311432.1_prot_XP_012268702.1_8467 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311964.1_prot_XP_025602536.1_13909 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311915.1_prot_XP_012262251.1_10166 2 Reactome: R-HSA-9010553;Reactome: R-HSA-975957 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311994.1_prot_XP_012267615.1_21766 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" lcl|NW_020311945.1_prot_XP_020706189.1_11817 13 MetaCyc: PWY-5030;MetaCyc: PWY-3841;KEGG: 00720+1.5.1.5+3.5.4.9;KEGG: 00720+6.3.4.3;MetaCyc: PWY-1722;Reactome: R-HSA-196757;MetaCyc: PWY-7909;KEGG: 00670+6.3.4.3;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-6613;MetaCyc: PWY-5497;MetaCyc: PWY-2161;MetaCyc: PWY-2201 "L-histidine degradation III";"Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"Carbon fixation pathways in prokaryotes";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Metabolism of folate and pterines";"Formaldehyde oxidation VII (THF pathway)";"One carbon pool by folate";"One carbon pool by folate";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine nucleobases degradation II (anaerobic)";"Folate polyglutamylation";"Folate transformations I" lcl|NW_020311513.1_prot_XP_012266039.1_9769 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311432.1_prot_XP_012268698.1_8407 1 Reactome: R-HSA-420029 "Tight junction interactions" lcl|NW_020311401.1_prot_XP_012254938.1_7682 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" lcl|NW_020311958.1_prot_XP_012255554.1_12924 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311957.1_prot_XP_012263400.1_12822 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311353.1_prot_XP_012256074.1_5401 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311974.1_prot_XP_012259928.1_16834 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311360.1_prot_XP_012251596.1_5734 1 Reactome: R-HSA-425366 "Transport of bile salts and organic acids, metal ions and amine compounds" lcl|NW_020311980.1_prot_XP_012255748.1_18906 29 Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-5696400;Reactome: R-HSA-73863;Reactome: R-HSA-6796648;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-72086;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-73779;Reactome: R-HSA-167246;Reactome: R-HSA-6781827;Reactome: R-HSA-167161;Reactome: R-HSA-5696395;Reactome: R-HSA-167152;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-6782135;Reactome: R-HSA-73772;Reactome: R-HSA-167172;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-75953;Reactome: R-HSA-674695 "NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER";"RNA Polymerase I Transcription Termination";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"mRNA Capping";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Tat-mediated elongation of the HIV-1 transcript";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"HIV Transcription Initiation";"Formation of Incision Complex in GG-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Dual incision in TC-NER";"RNA Polymerase I Promoter Escape";"Transcription of the HIV genome";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events" lcl|NW_020311994.1_prot_XP_012267370.1_21758 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311959.1_prot_XP_025602472.1_13071 2 KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685 "Glutathione metabolism";"Detoxification of Reactive Oxygen Species" lcl|NW_020311966.1_prot_XP_012256794.1_15200 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311961.1_prot_XP_012262594.1_13288 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311983.1_prot_XP_012268326.1_19554 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311983.1_prot_XP_012255642.1_19797 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311943.1_prot_XP_012255253.1_11683 1 Reactome: R-HSA-6803204 "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" lcl|NW_020311292.1_prot_XP_020706872.1_562 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311961.1_prot_XP_012262514.1_13318 2 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.7 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311985.1_prot_XP_020711103.1_20240 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311376.1_prot_XP_025601931.1_6562 3 KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1 "Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis" lcl|NW_020311942.1_prot_XP_012252450.1_11462 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" lcl|NW_020311990.1_prot_XP_012266590.1_20836 2 KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336 "Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway" lcl|NW_020311962.1_prot_XP_020706702.1_13594 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311311.1_prot_XP_020706397.1_2530 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311513.1_prot_XP_012266148.1_9729 1 Reactome: R-HSA-400253 "Circadian Clock" lcl|NW_020311361.1_prot_XP_012261508.1_5789 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311965.1_prot_XP_012260081.1_14149 6 Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-156827 "Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression" lcl|NW_020311432.1_prot_XP_012268601.1_8474 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311966.1_prot_XP_012256413.1_15161 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" lcl|NW_020311411.1_prot_XP_012256247.1_7851 5 KEGG: 00513+2.4.1.68;KEGG: 00510+2.4.1.68;MetaCyc: PWY-7426;Reactome: R-HSA-975578;KEGG: 00533+2.4.1.68 "Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Reactions specific to the complex N-glycan synthesis pathway";"Glycosaminoglycan biosynthesis - keratan sulfate" lcl|NW_020311311.1_prot_XP_012250890.1_2450 10 MetaCyc: PWY-7559;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4061;MetaCyc: PWY-5826;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-7112;MetaCyc: PWY-6842;MetaCyc: PWY-8001;MetaCyc: PWY-4041 "Glutathione degradation (DUG pathway";"Cyanoamino acid metabolism";"Glutathione-mediated detoxification I";"Hypoglycin biosynthesis";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification II";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Gamma-glutamyl cycle" lcl|NW_020311966.1_prot_XP_020708097.1_14802 1 Reactome: R-HSA-5689877 "Josephin domain DUBs" lcl|NW_020311973.1_prot_XP_020708913.1_16475 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311310.1_prot_XP_012255806.1_2443 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311331.1_prot_XP_012264331.1_4061 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" lcl|NW_020311984.1_prot_XP_012267788.1_20181 4 KEGG: 00430+1.13.11.20;MetaCyc: PWY-5331;Reactome: R-HSA-1614558;KEGG: 00270+1.13.11.20 "Taurine and hypotaurine metabolism";"Taurine biosynthesis I";"Degradation of cysteine and homocysteine";"Cysteine and methionine metabolism" lcl|NW_020311432.1_prot_XP_012268786.1_8477 6 Reactome: R-HSA-399997;Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-416476;Reactome: R-HSA-456926;Reactome: R-HSA-434316 "Acetylcholine regulates insulin secretion";"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"G alpha (q) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion" lcl|NW_020311290.1_prot_XP_012268970.1_449 17 MetaCyc: PWY-7179-1;MetaCyc: PWY-6609;MetaCyc: PWY-4202;KEGG: 00240+2.4.2.1;MetaCyc: PWY-6620;MetaCyc: PWY-5695;Reactome: R-HSA-74217;KEGG: 00230+2.4.2.1;Reactome: R-HSA-6798695;MetaCyc: PWY-6627;MetaCyc: PWY-7179;MetaCyc: PWY-5532;MetaCyc: PWY-6608;MetaCyc: PWY-6644;Reactome: R-HSA-74259;MetaCyc: PWY-6611;KEGG: 00760+2.4.2.1 "Purine deoxyribonucleosides degradation II";"Adenine and adenosine salvage III";"Arsenate detoxification I (mammalian)";"Pyrimidine metabolism";"Guanine and guanosine salvage";"Inosine 5'-phosphate degradation";"Purine salvage";"Purine metabolism";"Neutrophil degranulation";"Salinosporamide A biosynthesis";"Purine deoxyribonucleosides degradation I";"Nucleoside and nucleotide degradation (archaea)";"Guanosine nucleotides degradation III";"Fluoroacetate and fluorothreonine biosynthesis";"Purine catabolism";"Adenine and adenosine salvage V";"Nicotinate and nicotinamide metabolism" lcl|NW_020311962.1_prot_XP_020706700.1_13596 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311393.1_prot_XP_012265747.1_7152 7 MetaCyc: PWY-5686;MetaCyc: PWY-7790;KEGG: 00240+3.5.2.3;MetaCyc: PWY-7791;MetaCyc: PWY-5697;MetaCyc: PWY-5698;KEGG: 00230+3.5.2.5 "UMP biosynthesis I";"UMP biosynthesis II";"Pyrimidine metabolism";"UMP biosynthesis III";"Allantoin degradation to ureidoglycolate I (urea producing)";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Purine metabolism" lcl|NW_020311368.1_prot_XP_012264373.3_6230 3 Reactome: R-HSA-416476;Reactome: R-HSA-375276;Reactome: R-HSA-418594 "G alpha (q) signalling events";"Peptide ligand-binding receptors";"G alpha (i) signalling events" lcl|NW_020311983.1_prot_XP_012267196.1_19483 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311433.1_prot_XP_020710645.1_8607 5 KEGG: 00250+2.6.1.16;MetaCyc: PWY-6749;MetaCyc: PWY-8013;KEGG: 00520+2.6.1.16;Reactome: R-HSA-446210 "Alanine, aspartate and glutamate metabolism";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine" lcl|NW_020311994.1_prot_XP_025603021.1_21511 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311982.1_prot_XP_012258254.1_19218 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311305.1_prot_XP_012264169.1_1995 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311978.1_prot_XP_012257794.1_18271 3 Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing" lcl|NW_020311313.1_prot_XP_012261964.1_2957 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" lcl|NW_020311309.1_prot_XP_012259132.1_2372 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311958.1_prot_XP_012255634.1_12936 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311286.1_prot_XP_020708265.1_145 6 MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508 "Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis" lcl|NW_020311309.1_prot_XP_012259145.1_2363 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" lcl|NW_020311981.1_prot_XP_012257371.1_19176 2 Reactome: R-HSA-1660662;Reactome: R-HSA-390471 "Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis" lcl|NW_020311995.1_prot_XP_012257156.1_21943 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311982.1_prot_XP_012258437.1_19269 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311292.1_prot_XP_012252464.1_530 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311299.1_prot_XP_025602565.1_1415 5 MetaCyc: PWY-7921;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;KEGG: 00515+2.4.1.109 "Protein O-mannosylation I (yeast)";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Mannose type O-glycan biosynthesis" lcl|NW_020311959.1_prot_XP_020710144.1_13118 5 MetaCyc: PWY-5667;MetaCyc: PWY-5981;KEGG: 00564+2.7.7.41;MetaCyc: PWY-7817;KEGG: 04070+2.7.7.41 "CDP-diacylglycerol biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system" lcl|NW_020311993.1_prot_XP_012261541.1_21299 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311513.1_prot_XP_012266034.1_9767 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311348.1_prot_XP_012269846.1_5126 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311940.1_prot_XP_012265640.1_11257 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311971.1_prot_XP_012260835.1_15906 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" lcl|NW_020311983.1_prot_XP_012267142.1_19469 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" lcl|NW_020311983.1_prot_XP_020711786.1_19451 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311983.1_prot_XP_012255646.1_19800 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311286.1_prot_XP_012256442.1_217 11 MetaCyc: PWY-922;MetaCyc: PWY-6859;KEGG: 00900+5.3.3.2;Reactome: R-HSA-191273;MetaCyc: PWY-7102;MetaCyc: PWY-7391;MetaCyc: PWY-7560;MetaCyc: PWY-6174;MetaCyc: PWY-7524;MetaCyc: PWY-6383;MetaCyc: PWY-5123 "Mevalonate pathway I";"All-trans-farnesol biosynthesis";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"Bisabolene biosynthesis (engineered)";"Isoprene biosynthesis II (engineered)";"Methylerythritol phosphate pathway II";"Mevalonate pathway II (archaea)";"Mevalonate pathway III (archaea)";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis" lcl|NW_020311992.1_prot_XP_012266512.1_21170 6 KEGG: 00230+3.5.4.10+2.1.2.3;MetaCyc: PWY-6124;KEGG: 00670+2.1.2.3;MetaCyc: PWY-7234;MetaCyc: PWY-6123;Reactome: R-HSA-73817 "Purine metabolism";"Inosine-5'-phosphate biosynthesis II";"One carbon pool by folate";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis" lcl|NW_020311349.1_prot_XP_012262425.1_5158 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311305.1_prot_XP_012251486.1_2035 1 Reactome: R-HSA-196783 "Coenzyme A biosynthesis" lcl|NW_020311977.1_prot_XP_025602764.1_17923 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311413.1_prot_XP_012254391.1_7895 1 Reactome: R-HSA-425410 "Metal ion SLC transporters" lcl|NW_020311318.1_prot_XP_020707254.1_3307 2 Reactome: R-HSA-5620924;Reactome: R-HSA-5610787 "Intraflagellar transport";"Hedgehog 'off' state" lcl|NW_020311988.1_prot_XP_012269513.1_20540 14 MetaCyc: PWY-6453;MetaCyc: PWY-7417;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7411;MetaCyc: PWY-5981;MetaCyc: PWY-7589 "Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)" lcl|NW_020311311.1_prot_XP_012250903.1_2457 6 Reactome: R-HSA-73772;Reactome: R-HSA-427359;Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-73863;Reactome: R-HSA-73762 "RNA Polymerase I Promoter Escape";"SIRT1 negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation" lcl|NW_020311296.1_prot_XP_020711081.1_1008 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311993.1_prot_XP_012261539.1_21297 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311992.1_prot_XP_020711525.1_21272 14 KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-7417;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-8053;MetaCyc: PWY-7409;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482788;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-975634;KEGG: 00565+3.1.1.4 "Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Linoleic acid metabolism";"Plasmalogen degradation";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Arachidonic acid metabolism";"Acyl chain remodelling of PC";"alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Retinoid metabolism and transport";"Ether lipid metabolism" lcl|NW_020311918.1_prot_XP_012265116.1_10313 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311978.1_prot_XP_012258045.1_18287 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311968.1_prot_XP_012253069.1_15438 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311992.1_prot_XP_012266455.1_21120 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311966.1_prot_XP_012256225.1_15123 1 Reactome: R-HSA-163560 "Triglyceride catabolism" lcl|NW_020311962.1_prot_XP_012251971.1_13776 4 KEGG: 00510+2.4.1.131;KEGG: 00513+2.4.1.131;Reactome: R-HSA-446193;Reactome: R-HSA-4551295 "N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG11 causes ALG11-CDG (CDG-1p)" lcl|NW_020311313.1_prot_XP_012261670.1_2869 4 Reactome: R-HSA-8963889;Reactome: R-HSA-8874211;Reactome: R-HSA-1655829;Reactome: R-HSA-381033 "Assembly of active LPL and LIPC lipase complexes";"CREB3 factors activate genes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"ATF6 (ATF6-alpha) activates chaperones" lcl|NW_020311296.1_prot_XP_012265305.1_987 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311373.1_prot_XP_012266679.1_6435 13 Reactome: R-HSA-5627117;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3928663;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04926+2.7.11.1;Reactome: R-HSA-3928662;Reactome: R-HSA-416572;Reactome: R-HSA-4420097;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1 "RHO GTPases Activate ROCKs";"mTOR signaling pathway";"EPHA-mediated growth cone collapse";"Human immunodeficiency virus 1 infection";"Thermogenesis";"G alpha (12/13) signalling events";"Relaxin signaling pathway";"EPHB-mediated forward signaling";"Sema4D induced cell migration and growth-cone collapse";"VEGFA-VEGFR2 Pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway" lcl|NW_020311954.1_prot_XP_020712069.1_12338 2 KEGG: 04070+2.7.11.13;Reactome: R-HSA-5625740 "Phosphatidylinositol signaling system";"RHO GTPases activate PKNs" lcl|NW_020311320.1_prot_XP_012268078.1_3395 4 Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76071 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" lcl|NW_020311974.1_prot_XP_012260300.1_16894 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311986.1_prot_XP_012258888.1_20345 6 Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513 "KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" lcl|NW_020311956.1_prot_XP_020706567.1_12623 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311959.1_prot_XP_012262300.1_13106 1 Reactome: R-HSA-196108 "Pregnenolone biosynthesis" lcl|NW_020311975.1_prot_XP_025602712.1_16949 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311973.1_prot_XP_020708834.1_16396 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311312.1_prot_XP_012266795.1_2609 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311978.1_prot_XP_020708573.1_18060 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311978.1_prot_XP_020708559.1_18399 7 Reactome: R-HSA-2894862;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;MetaCyc: PWY-7511;Reactome: R-HSA-2691232 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants" lcl|NW_020311329.1_prot_XP_012269617.1_3992 1 Reactome: R-HSA-71064 "Lysine catabolism" lcl|NW_020311334.1_prot_XP_020711371.1_4370 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311970.1_prot_XP_012269063.1_15668 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311971.1_prot_XP_012260821.1_15843 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311286.1_prot_XP_012256437.1_241 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311432.1_prot_XP_012268811.1_8421 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311982.1_prot_XP_012264623.1_19378 2 Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28 "Digestion of dietary carbohydrate";"Starch and sucrose metabolism" lcl|NW_020311978.1_prot_XP_012257854.1_18203 2 KEGG: 00770+2.7.1.24;MetaCyc: PWY-7851 "Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis II (eukaryotic)" lcl|NW_020311945.1_prot_XP_020710147.1_11830 14 KEGG: 00062+2.3.1.199;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-5080;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7601;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7725 "Fatty acid elongation";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)" lcl|NW_020311976.1_prot_XP_012253603.1_17285 2 MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10 "CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311985.1_prot_XP_020711111.1_20256 6 MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733 "Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis" lcl|NW_020311292.1_prot_XP_020706868.1_558 4 MetaCyc: PWY-7268;KEGG: 00480+1.1.1.49;MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49 "NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism";"Entner-Doudoroff pathway I";"Pentose phosphate pathway" lcl|NW_020311995.1_prot_XP_012257153.1_21944 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311296.1_prot_XP_012265123.1_1029 1 Reactome: R-HSA-428890 "Role of ABL in ROBO-SLIT signaling" lcl|NW_020311907.1_prot_XP_012264885.1_10149 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311981.1_prot_XP_012257456.1_19073 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311964.1_prot_XP_012261937.1_13958 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311966.1_prot_XP_012256215.1_14833 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311418.1_prot_XP_012260996.1_8014 3 KEGG: 00230+2.7.1.20;Reactome: R-HSA-74217;MetaCyc: PWY-6619 "Purine metabolism";"Purine salvage";"Adenine and adenosine salvage VI" lcl|NW_020311981.1_prot_XP_012257433.1_18950 8 Reactome: R-HSA-5689880;Reactome: R-HSA-8948747;Reactome: R-HSA-6804757;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-8866652;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827 "Ub-specific processing proteases";"Regulation of PTEN localization";"Regulation of TP53 Degradation";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)" lcl|NW_020311988.1_prot_XP_020712206.1_20611 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" lcl|NW_020311977.1_prot_XP_012263712.1_17850 6 MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782 "Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311418.1_prot_XP_012261028.1_8038 3 Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807 "Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism" lcl|NW_020311926.1_prot_XP_012250864.1_10614 9 Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616 "Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange" lcl|NW_020311286.1_prot_XP_012256555.1_155 13 KEGG: 00620+4.2.1.2;MetaCyc: PWY-5913;MetaCyc: PWY-7254;KEGG: 00020+4.2.1.2;MetaCyc: PWY-6969;MetaCyc: PWY-5690;MetaCyc: PWY-6728;MetaCyc: PWY-5392;MetaCyc: PWY-561;KEGG: 00720+4.2.1.2;MetaCyc: PWY-8086;Reactome: R-HSA-71403;MetaCyc: PWY-7384 "Pyruvate metabolism";"Partial TCA cycle (obligate autotrophs)";"TCA cycle VII (acetate-producers)";"Citrate cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Reductive TCA cycle II";"Superpathway of glyoxylate cycle and fatty acid degradation";"Carbon fixation pathways in prokaryotes";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Citric acid cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)" lcl|NW_020311356.1_prot_XP_012267077.1_5517 2 Reactome: R-HSA-71403;Reactome: R-HSA-611105 "Citric acid cycle (TCA cycle)";"Respiratory electron transport" lcl|NW_020311994.1_prot_XP_025603012.1_21706 14 MetaCyc: PWY-7254;MetaCyc: PWY-6969;MetaCyc: PWY-4302;MetaCyc: PWY-561;KEGG: 00720+1.3.5.1;MetaCyc: PWY-6728;MetaCyc: PWY-5690;KEGG: 00190+1.3.5.1;KEGG: 00020+1.3.5.1;MetaCyc: PWY-3781;Reactome: R-HSA-611105;MetaCyc: PWY-7279;KEGG: 00650+1.3.5.1;Reactome: R-HSA-71403 "TCA cycle VII (acetate-producers)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Carbon fixation pathways in prokaryotes";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Oxidative phosphorylation";"Citrate cycle (TCA cycle)";"Aerobic respiration I (cytochrome c)";"Respiratory electron transport";"Aerobic respiration II (cytochrome c) (yeast)";"Butanoate metabolism";"Citric acid cycle (TCA cycle)" lcl|NW_020311423.1_prot_XP_012251569.1_8176 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311995.1_prot_XP_020708157.1_22032 9 Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-73779 "Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" lcl|NW_020311974.1_prot_XP_012259846.1_16699 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311983.1_prot_XP_020707935.1_19733 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" lcl|NW_020311940.1_prot_XP_012252804.1_11130 6 Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72706 "Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311967.1_prot_XP_020707510.1_15285 7 KEGG: 00860+6.1.1.17;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.15;MetaCyc: PWY-5188;Reactome: R-HSA-2408522;Reactome: R-HSA-6782315;KEGG: 00970+6.1.1.17 "Porphyrin and chlorophyll metabolism";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Selenoamino acid metabolism";"tRNA modification in the nucleus and cytosol";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311992.1_prot_XP_020711532.1_21088 17 Reactome: R-HSA-6804756;Reactome: R-HSA-6796648;Reactome: R-HSA-1433557;KEGG: 04150+2.7.11.1;Reactome: R-HSA-8953750;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5693607;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693616;Reactome: R-HSA-176187;KEGG: 04926+2.7.11.1;Reactome: R-HSA-75035;Reactome: R-HSA-69473;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-69601 "Regulation of TP53 Activity through Phosphorylation";"TP53 Regulates Transcription of DNA Repair Genes";"Signaling by SCF-KIT";"mTOR signaling pathway";"Transcriptional Regulation by E2F6";"Thermogenesis";"Processing of DNA double-strand break ends";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"Relaxin signaling pathway";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"G2/M DNA damage checkpoint";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A" lcl|NW_020311304.1_prot_XP_025602748.1_1959 7 Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-2644606;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096 "NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus" lcl|NW_020311971.1_prot_XP_012263592.1_16062 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311397.1_prot_XP_020708712.1_7288 3 Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" lcl|NW_020311959.1_prot_XP_012254236.1_13211 1 Reactome: R-HSA-525793 "Myogenesis" lcl|NW_020311361.1_prot_XP_012261582.1_5824 4 MetaCyc: PWY-6902;MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14 "Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311372.1_prot_XP_020712148.1_6300 4 Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311381.1_prot_XP_012252331.1_6831 14 Reactome: R-HSA-8934593;Reactome: R-HSA-8948700;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-203927;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-426486;Reactome: R-HSA-4086398;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408 "Regulation of RUNX1 Expression and Activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"MicroRNA (miRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Small interfering RNA (siRNA) biogenesis";"Ca2+ pathway";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation" lcl|NW_020311967.1_prot_XP_012254333.1_15337 4 Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-72764 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination" lcl|NW_020311396.1_prot_XP_025601982.1_7270 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311334.1_prot_XP_012265948.1_4384 1 KEGG: 00970+6.1.1.19 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311966.1_prot_XP_012256530.1_15017 2 Reactome: R-HSA-6798695;Reactome: R-HSA-532668 "Neutrophil degranulation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle" lcl|NW_020311293.1_prot_XP_020710561.1_857 1 Reactome: R-HSA-532668 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" lcl|NW_020311956.1_prot_XP_012254590.1_12579 4 Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-5625970 "COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Kinesins";"RHO GTPases activate KTN1" lcl|NW_020311973.1_prot_XP_020708928.1_16631 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311433.1_prot_XP_012264018.1_8610 5 Reactome: R-HSA-446210;MetaCyc: PWY-8013;KEGG: 00520+2.6.1.16;KEGG: 00250+2.6.1.16;MetaCyc: PWY-6749 "Synthesis of UDP-N-acetyl-glucosamine";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Amino sugar and nucleotide sugar metabolism";"Alanine, aspartate and glutamate metabolism";"CMP-legionaminate biosynthesis I" lcl|NW_020311312.1_prot_XP_012266914.1_2616 5 KEGG: 00620+4.1.1.32;KEGG: 00020+4.1.1.32;Reactome: R-HSA-70263;MetaCyc: PWY-7383;KEGG: 00010+4.1.1.32 "Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis / Gluconeogenesis" lcl|NW_020311958.1_prot_XP_012260386.1_12901 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311418.1_prot_XP_012261012.1_8005 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311424.1_prot_XP_020707856.1_8183 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311361.1_prot_XP_012261553.1_5807 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311907.1_prot_XP_020710986.1_10143 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311304.1_prot_XP_012260537.1_1773 5 Reactome: R-HSA-8849471;Reactome: R-HSA-186763;Reactome: R-HSA-5218921;Reactome: R-HSA-3928662;Reactome: R-HSA-5658442 "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases";"Downstream signal transduction";"VEGFR2 mediated cell proliferation";"EPHB-mediated forward signaling";"Regulation of RAS by GAPs" lcl|NW_020311985.1_prot_XP_012265231.1_20219 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311317.1_prot_XP_012251538.1_3201 4 Reactome: R-HSA-982772;Reactome: R-HSA-2586552;Reactome: R-HSA-1170546;Reactome: R-HSA-983231 "Growth hormone receptor signaling";"Signaling by Leptin";"Prolactin receptor signaling";"Factors involved in megakaryocyte development and platelet production" lcl|NW_020311965.1_prot_XP_012259973.1_14216 5 Reactome: R-HSA-532668;Reactome: R-HSA-4793954;KEGG: 00510+3.2.1.106;MetaCyc: PWY-7918;MetaCyc: PWY-7919 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-Glycan biosynthesis";"Protein N-glycosylation processing phase (yeast)";"Protein N-glycosylation processing phase (plants and animals)" lcl|NW_020311970.1_prot_XP_012269098.1_15682 4 MetaCyc: PWY-7285;MetaCyc: PWY-7286;MetaCyc: PWY-6829;Reactome: R-HSA-6782315 "Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol" lcl|NW_020311955.1_prot_XP_012265480.1_12432 6 Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-6791226 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311309.1_prot_XP_012259101.1_2396 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311286.1_prot_XP_020708385.1_237 1 Reactome: R-HSA-427601 "Multifunctional anion exchangers" lcl|NW_020311436.1_prot_XP_012258222.1_8781 3 KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596 "Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I" lcl|NW_020311992.1_prot_XP_012266357.1_21140 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311992.1_prot_XP_012266539.1_21019 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311934.1_prot_XP_020707747.1_10821 2 KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20 "Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism" lcl|NW_020311315.1_prot_XP_012265277.1_3106 19 Reactome: R-HSA-5625970;Reactome: R-HSA-983231;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-182971;Reactome: R-HSA-5687128;Reactome: R-HSA-525793;Reactome: R-HSA-8964616;Reactome: R-HSA-5627123;Reactome: R-HSA-389359;Reactome: R-HSA-5626467;Reactome: R-HSA-5663213;Reactome: R-HSA-418885;Reactome: R-HSA-8950505;Reactome: R-HSA-2029482;Reactome: R-HSA-5663220;Reactome: R-HSA-4420097;Reactome: R-HSA-428543;Reactome: R-HSA-3928662 "RHO GTPases activate KTN1";"Factors involved in megakaryocyte development and platelet production";"Rho GTPase cycle";"GPVI-mediated activation cascade";"EGFR downregulation";"MAPK6/MAPK4 signaling";"Myogenesis";"G beta:gamma signalling through CDC42";"RHO GTPases activate PAKs";"CD28 dependent Vav1 pathway";"RHO GTPases activate IQGAPs";"RHO GTPases Activate WASPs and WAVEs";"DCC mediated attractive signaling";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate Formins";"VEGFA-VEGFR2 Pathway";"Inactivation of CDC42 and RAC1";"EPHB-mediated forward signaling" lcl|NW_020311309.1_prot_XP_020709065.1_2373 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311940.1_prot_XP_012265639.1_11258 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311477.1_prot_XP_012262223.1_9440 2 Reactome: R-HSA-3238698;Reactome: R-HSA-373080 "WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)" lcl|NW_020311286.1_prot_XP_025602973.1_48 7 KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection" lcl|NW_020311977.1_prot_XP_012252233.1_17461 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311934.1_prot_XP_012255032.1_10826 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311339.1_prot_XP_012252808.1_4657 6 Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA" lcl|NW_020311977.1_prot_XP_025602759.1_17920 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311349.1_prot_XP_012251224.1_5287 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311977.1_prot_XP_020710543.1_17769 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311289.1_prot_XP_012256167.1_398 4 KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3 "Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism" lcl|NW_020311339.1_prot_XP_020707693.1_4603 2 Reactome: R-HSA-6783310;Reactome: R-HSA-6796648 "Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes" lcl|NW_020311416.1_prot_XP_012253688.1_7939 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311337.1_prot_XP_012251807.1_4469 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311962.1_prot_XP_012251933.1_13685 2 Reactome: R-HSA-8876198;Reactome: R-HSA-6811436 "RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311317.1_prot_XP_012251547.1_3200 4 Reactome: R-HSA-982772;Reactome: R-HSA-2586552;Reactome: R-HSA-983231;Reactome: R-HSA-1170546 "Growth hormone receptor signaling";"Signaling by Leptin";"Factors involved in megakaryocyte development and platelet production";"Prolactin receptor signaling" lcl|NW_020311308.1_prot_XP_012264433.1_2167 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" lcl|NW_020311958.1_prot_XP_012255487.1_12981 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311940.1_prot_XP_020711245.1_11335 5 Reactome: R-HSA-389357;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-5674400;Reactome: R-HSA-5218920 "CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability" lcl|NW_020311934.1_prot_XP_012255275.1_10845 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" lcl|NW_020311987.1_prot_XP_012251815.1_20451 5 Reactome: R-HSA-381183;Reactome: R-HSA-1989781;Reactome: R-HSA-380994;Reactome: R-HSA-2426168;Reactome: R-HSA-9614657 "ATF6 (ATF6-alpha) activates chaperone genes";"PPARA activates gene expression";"ATF4 activates genes in response to endoplasmic reticulum stress";"Activation of gene expression by SREBF (SREBP)";"FOXO-mediated transcription of cell death genes" lcl|NW_020311308.1_prot_XP_012264421.1_2197 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311991.1_prot_XP_012269741.1_20924 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311320.1_prot_XP_012259287.1_3352 3 KEGG: 00790+4.2.1.96;MetaCyc: PWY-7158;MetaCyc: PWY-8099 "Folate biosynthesis";"L-phenylalanine degradation V";"Tetrahydropteridine recycling" lcl|NW_020311343.1_prot_XP_012268666.1_4765 12 KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-1632852;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-9619483;KEGG: 04926+2.7.11.1;Reactome: R-HSA-380972;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Human papillomavirus infection";"Macroautophagy";"PI3K-Akt signaling pathway";"Thermogenesis";"TP53 Regulates Metabolic Genes";"Activation of AMPK downstream of NMDARs";"Relaxin signaling pathway";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Human immunodeficiency virus 1 infection" lcl|NW_020311367.1_prot_XP_020709017.1_6086 2 MetaCyc: PWY-6502;Reactome: R-HSA-2393930 "8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins" lcl|NW_020311349.1_prot_XP_012262424.1_5157 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311309.1_prot_XP_012259118.1_2348 3 Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing" lcl|NW_020311456.1_prot_XP_012255829.1_9103 16 Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702 "Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition" lcl|NW_020311943.1_prot_XP_012255278.1_11626 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311978.1_prot_XP_020708575.1_18055 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" lcl|NW_020311432.1_prot_XP_012268814.1_8420 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311956.1_prot_XP_012254442.1_12568 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" lcl|NW_020311983.1_prot_XP_012267223.1_19495 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" lcl|NW_020311940.1_prot_XP_012265643.1_11243 14 MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-5972;MetaCyc: PWY-7619;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-7036 "Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II" lcl|NW_020311946.1_prot_XP_012268743.1_11903 1 Reactome: R-HSA-5689901 "Metalloprotease DUBs" lcl|NW_020311981.1_prot_XP_012257447.1_18945 14 MetaCyc: PWY-3841;MetaCyc: PWY-3661-1;KEGG: 00680+2.1.2.1;MetaCyc: PWY-1622;Reactome: R-HSA-196757;MetaCyc: PWY-181;KEGG: 00260+2.1.2.1;KEGG: 00670+2.1.2.1;KEGG: 00460+2.1.2.1;MetaCyc: PWY-2201;MetaCyc: PWY-2161;MetaCyc: PWY-3661;MetaCyc: PWY-5497;KEGG: 00630+2.1.2.1 "Folate transformations II (plants)";"Glycine betaine degradation II (mammalian)";"Methane metabolism";"Formaldehyde assimilation I (serine pathway)";"Metabolism of folate and pterines";"Photorespiration ";"Glycine, serine and threonine metabolism";"One carbon pool by folate";"Cyanoamino acid metabolism";"Folate transformations I";"Folate polyglutamylation";"Glycine betaine degradation I";"Purine nucleobases degradation II (anaerobic)";"Glyoxylate and dicarboxylate metabolism" lcl|NW_020311298.1_prot_XP_012269936.1_1192 5 MetaCyc: PWY-6121;KEGG: 00230+6.3.5.3;Reactome: R-HSA-73817;MetaCyc: PWY-6277;MetaCyc: PWY-6122 "5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II" lcl|NW_020311940.1_prot_XP_020711233.1_11200 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311309.1_prot_XP_012259095.1_2390 11 KEGG: 00630+6.3.1.2;KEGG: 00250+6.3.1.2;Reactome: R-HSA-210455;MetaCyc: PWY-6964;Reactome: R-HSA-8964539;MetaCyc: PWY-5675;KEGG: 00220+6.3.1.2;MetaCyc: PWY-381;KEGG: 00910+6.3.1.2;MetaCyc: PWY-6963;MetaCyc: PWY-6549 "Glyoxylate and dicarboxylate metabolism";"Alanine, aspartate and glutamate metabolism";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Ammonia assimilation cycle II";"Glutamate and glutamine metabolism";"Nitrate reduction V (assimilatory)";"Arginine biosynthesis";"Nitrate reduction II (assimilatory)";"Nitrogen metabolism";"Ammonia assimilation cycle I";"L-glutamine biosynthesis III" lcl|NW_020311980.1_prot_XP_012254911.1_18710 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311959.1_prot_XP_012259372.1_13190 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311365.1_prot_XP_020712487.1_5994 4 Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862 "NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants" lcl|NW_020311292.1_prot_XP_020710268.1_694 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-112308 "NCAM1 interactions";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening" lcl|NW_020311940.1_prot_XP_012265563.1_11193 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311436.1_prot_XP_012258117.2_8769 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311332.1_prot_XP_012268536.1_4124 16 Reactome: R-HSA-8856828;Reactome: R-HSA-8866427;Reactome: R-HSA-3928665;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-182218;Reactome: R-HSA-8964038;Reactome: R-HSA-5099900;Reactome: R-HSA-8856825;Reactome: R-HSA-164939;Reactome: R-HSA-177504;Reactome: R-HSA-416993;Reactome: R-HSA-5140745;Reactome: R-HSA-167590;Reactome: R-HSA-437239;Reactome: R-HSA-2132295 "Clathrin-mediated endocytosis";"VLDLR internalisation and degradation";"EPH-ephrin mediated repulsion of cells";"Gap junction degradation";"Formation of annular gap junctions";"Nef Mediated CD8 Down-regulation";"LDL clearance";"WNT5A-dependent internalization of FZD4";"Cargo recognition for clathrin-mediated endocytosis";"Nef mediated downregulation of CD28 cell surface expression";"Retrograde neurotrophin signalling";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Nef Mediated CD4 Down-regulation";"Recycling pathway of L1";"MHC class II antigen presentation" lcl|NW_020311968.1_prot_XP_012265933.1_15499 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" lcl|NW_020311989.1_prot_XP_012263227.1_20778 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311968.1_prot_XP_012253068.1_15439 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311969.1_prot_XP_012264786.1_15544 2 Reactome: R-HSA-975957;Reactome: R-HSA-9010553 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311984.1_prot_XP_012254622.1_19910 1 Reactome: R-HSA-1362409 "Mitochondrial iron-sulfur cluster biogenesis" lcl|NW_020311994.1_prot_XP_012267513.1_21667 56 Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9010553;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5610785;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-8852276;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-187577;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-174084;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-5668541;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236 "Degradation of DVL";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Regulation of expression of SLITs and ROBOs";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"G2/M Checkpoints";"Regulation of RAS by GAPs";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"SCF(Skp2)-mediated degradation of p27/p21";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"TNFR2 non-canonical NF-kB pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs" lcl|NW_020311396.1_prot_XP_025601979.1_7230 11 Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-418555;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;Reactome: R-HSA-418597;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-163615 "Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"G alpha (s) signalling events";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"G alpha (z) signalling events";"Purine metabolism";"Adenylate cyclase activating pathway";"PKA activation" lcl|NW_020311971.1_prot_XP_020710525.1_16075 12 Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690 "MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"HCMV Early Events" lcl|NW_020311982.1_prot_XP_020708762.1_19217 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311423.1_prot_XP_012251565.1_8166 6 Reactome: R-HSA-189085;KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.18;MetaCyc: PWY-7900;MetaCyc: PWY-622 "Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch biosynthesis" lcl|NW_020311971.1_prot_XP_020709604.1_15861 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" lcl|NW_020311342.1_prot_XP_012255764.1_4751 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311346.1_prot_XP_012262913.1_5002 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311401.1_prot_XP_012254888.1_7562 3 Reactome: R-HSA-3108214;Reactome: R-HSA-5693571;Reactome: R-HSA-164843 "SUMOylation of DNA damage response and repair proteins";"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation" lcl|NW_020311456.1_prot_XP_012255831.1_9112 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311401.1_prot_XP_012254738.1_7549 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311990.1_prot_XP_012266754.1_20830 3 Reactome: R-HSA-6784531;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470 "tRNA processing in the nucleus";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion" lcl|NW_020311401.1_prot_XP_012255046.1_7685 4 Reactome: R-HSA-5689603;MetaCyc: PWY-7437;KEGG: 00514+2.4.1.255;Reactome: R-HSA-3214847 "UCH proteinases";"Protein O-[N-acetyl]-glucosylation";"Other types of O-glycan biosynthesis";"HATs acetylate histones" lcl|NW_020311353.1_prot_XP_020708021.1_5465 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311966.1_prot_XP_012256372.1_14954 7 Reactome: R-HSA-5626467;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025 "RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311977.1_prot_XP_012263785.1_17700 11 Reactome: R-HSA-380270;Reactome: R-HSA-6811436;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-2132295;Reactome: R-HSA-8854518;Reactome: R-HSA-6807878;Reactome: R-HSA-5620912 "Recruitment of mitotic centrosome proteins and complexes";"COPI-independent Golgi-to-ER retrograde traffic";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"MHC class II antigen presentation";"AURKA Activation by TPX2";"COPI-mediated anterograde transport";"Anchoring of the basal body to the plasma membrane" lcl|NW_020311465.1_prot_XP_012268979.1_9272 11 Reactome: R-HSA-1834949;Reactome: R-HSA-5693571;KEGG: 04151+2.7.11.1;Reactome: R-HSA-8866654;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3270619;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1 "Cytosolic sensors of pathogen-associated DNA";"Nonhomologous End-Joining (NHEJ)";"PI3K-Akt signaling pathway";"E3 ubiquitin ligases ubiquitinate target proteins";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"IRF3-mediated induction of type I IFN";"Relaxin signaling pathway";"Thermogenesis" lcl|NW_020311965.1_prot_XP_012259936.1_14252 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311957.1_prot_XP_012263318.1_12770 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311907.1_prot_XP_012264884.1_10148 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311306.1_prot_XP_012264216.1_2102 3 Reactome: R-HSA-191859;Reactome: R-HSA-72165;Reactome: R-HSA-72163 "snRNP Assembly";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" lcl|NW_020311337.1_prot_XP_012254373.2_4425 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311348.1_prot_XP_012269847.1_5108 11 Reactome: R-HSA-5673001;Reactome: R-HSA-1963642;Reactome: R-HSA-1250196;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993;Reactome: R-HSA-9664565;Reactome: R-HSA-2219530;Reactome: R-HSA-6785631;Reactome: R-HSA-6811558;Reactome: R-HSA-8863795;Reactome: R-HSA-1227986 "RAF/MAP kinase cascade";"PI3K events in ERBB2 signaling";"SHC1 events in ERBB2 signaling";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling";"Signaling by ERBB2 KD Mutants";"Constitutive Signaling by Aberrant PI3K in Cancer";"ERBB2 Regulates Cell Motility";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downregulation of ERBB2 signaling";"Signaling by ERBB2" lcl|NW_020311958.1_prot_XP_012255524.1_12958 3 Reactome: R-HSA-6798695;Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "Neutrophil degranulation";"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" lcl|NW_020311332.1_prot_XP_012256946.1_4150 29 Reactome: R-HSA-5696397;Reactome: R-HSA-6804756;Reactome: R-HSA-110320;Reactome: R-HSA-69166;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5696400;Reactome: R-HSA-6783310;Reactome: R-HSA-68962;Reactome: R-HSA-110312;Reactome: R-HSA-5358565;Reactome: R-HSA-5358606;Reactome: R-HSA-110314;Reactome: R-HSA-5655862;Reactome: R-HSA-174437;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-3371511;Reactome: R-HSA-6782210;Reactome: R-HSA-5693616;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-3371453;Reactome: R-HSA-3108214;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-5656121;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942 "Gap-filling DNA repair synthesis and ligation in GG-NER";"Regulation of TP53 Activity through Phosphorylation";"Translesion Synthesis by POLH";"Removal of the Flap Intermediate";"Processing of DNA double-strand break ends";"Meiotic recombination";"Dual Incision in GG-NER";"Fanconi Anemia Pathway";"Activation of the pre-replicative complex";"Translesion synthesis by REV1";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLK";"Removal of the Flap Intermediate from the C-strand";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"HSF1 activation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA damage response and repair proteins";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Translesion synthesis by POLI";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)" lcl|NW_020311959.1_prot_XP_020707486.1_13202 1 Reactome: R-HSA-197264 "Nicotinamide salvaging" lcl|NW_020311432.1_prot_XP_012268731.1_8417 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" lcl|NW_020311961.1_prot_XP_012262685.1_13361 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311959.1_prot_XP_025602487.1_13111 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311346.1_prot_XP_020710306.1_4957 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311966.1_prot_XP_012256731.1_14711 7 Reactome: R-HSA-76071;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-1834949;Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061 "RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" lcl|NW_020311982.1_prot_XP_020708805.1_19342 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311992.1_prot_XP_012260763.1_20956 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311362.1_prot_XP_020711002.1_5859 2 MetaCyc: PWY-6019;KEGG: 00240+4.2.1.70 "Pseudouridine degradation";"Pyrimidine metabolism" lcl|NW_020311967.1_prot_XP_012254340.1_15302 3 Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+2.10.1.1 "Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis" lcl|NW_020311321.1_prot_XP_012263244.1_3431 2 Reactome: R-HSA-2682334;Reactome: R-HSA-3928665 "EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells" lcl|NW_020311974.1_prot_XP_012260291.1_16890 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311352.1_prot_XP_025601833.1_5385 4 Reactome: R-HSA-1474228;Reactome: R-HSA-2243919;Reactome: R-HSA-2214320;Reactome: R-HSA-1650814 "Degradation of the extracellular matrix";"Crosslinking of collagen fibrils";"Anchoring fibril formation";"Collagen biosynthesis and modifying enzymes" lcl|NW_020311349.1_prot_XP_012251169.1_5232 7 Reactome: R-HSA-5628897;KEGG: 00250+3.5.1.2;Reactome: R-HSA-210500;KEGG: 00471+3.5.1.2;MetaCyc: PWY-5921;KEGG: 00220+3.5.1.2;Reactome: R-HSA-8964539 "TP53 Regulates Metabolic Genes";"Alanine, aspartate and glutamate metabolism";"Glutamate Neurotransmitter Release Cycle";"D-Glutamine and D-glutamate metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Arginine biosynthesis";"Glutamate and glutamine metabolism" lcl|NW_020311976.1_prot_XP_020707165.1_17210 3 KEGG: 04660+2.7.10.2;Reactome: R-HSA-4420097;Reactome: R-HSA-391160 "T cell receptor signaling pathway";"VEGFA-VEGFR2 Pathway";"Signal regulatory protein family interactions" lcl|NW_020311286.1_prot_XP_012256339.1_66 2 Reactome: R-HSA-9033241;Reactome: R-HSA-389661 "Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation" lcl|NW_020311953.1_prot_XP_025602412.1_12243 6 MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;Reactome: R-HSA-114508 "Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Effects of PIP2 hydrolysis" lcl|NW_020311388.1_prot_XP_012264840.1_6993 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311976.1_prot_XP_012257173.1_17396 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311436.1_prot_XP_012258379.1_8747 1 MetaCyc: PWY-7533 "Gliotoxin biosynthesis" lcl|NW_020311296.1_prot_XP_020711197.1_997 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311982.1_prot_XP_012264627.1_19387 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311971.1_prot_XP_012263626.1_16005 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311973.1_prot_XP_012258798.2_16550 16 Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Viral mRNA Translation";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination" lcl|NW_020311973.1_prot_XP_020708873.1_16350 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311978.1_prot_XP_012257725.1_18071 4 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311432.1_prot_XP_012268767.1_8547 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311965.1_prot_XP_012260259.1_14112 7 Reactome: R-HSA-177929;Reactome: R-HSA-2894862;Reactome: R-HSA-1442490;Reactome: R-HSA-2122948;Reactome: R-HSA-2660826;Reactome: R-HSA-2644606;Reactome: R-HSA-2691232 "Signaling by EGFR";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Collagen degradation";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants" lcl|NW_020311366.1_prot_XP_012253364.1_6053 5 Reactome: R-HSA-381426;Reactome: R-HSA-532668;Reactome: R-HSA-879415;Reactome: R-HSA-901042;Reactome: R-HSA-8957275 "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Advanced glycosylation endproduct receptor signaling";"Calnexin/calreticulin cycle";"Post-translational protein phosphorylation" lcl|NW_020311292.1_prot_XP_025601867.1_733 1 Reactome: R-HSA-5601884 "PIWI-interacting RNA (piRNA) biogenesis" lcl|NW_020311932.1_prot_XP_012257432.1_10726 1 Reactome: R-HSA-6790901 "rRNA modification in the nucleus and cytosol" lcl|NW_020311393.1_prot_XP_012265701.1_7126 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311443.1_prot_XP_020712018.2_8915 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" lcl|NW_020311977.1_prot_XP_020710694.1_17887 6 Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-7656;MetaCyc: PWY-6733 "Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis" lcl|NW_020311955.1_prot_XP_012265387.1_12411 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" lcl|NW_020311343.1_prot_XP_020708744.1_4782 3 Reactome: R-HSA-983168;Reactome: R-HSA-6798695;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"Protein ubiquitination" lcl|NW_020311326.1_prot_XP_012261523.1_3724 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311426.1_prot_XP_020712192.1_8256 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157 "MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions" lcl|NW_020311396.1_prot_XP_020706143.1_7267 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311332.1_prot_XP_012256553.1_4189 5 Reactome: R-HSA-73772;Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-73863 "RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination" lcl|NW_020311961.1_prot_XP_012262481.1_13543 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311976.1_prot_XP_012253618.1_17280 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" lcl|NW_020311959.1_prot_XP_020710103.1_13113 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311983.1_prot_XP_012255518.1_19710 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311990.1_prot_XP_012266426.1_20852 2 KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1 "Purine metabolism";"Pentose phosphate pathway" lcl|NW_020311991.1_prot_XP_012269737.1_20918 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311961.1_prot_XP_012262474.1_13541 33 Reactome: R-HSA-73863;Reactome: R-HSA-6796648;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-5696395;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-6782135;Reactome: R-HSA-112382;Reactome: R-HSA-69231;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-76042;Reactome: R-HSA-69656;Reactome: R-HSA-167200;Reactome: R-HSA-8939236;Reactome: R-HSA-167160;Reactome: R-HSA-73776;Reactome: R-HSA-69202;Reactome: R-HSA-167162;Reactome: R-HSA-69273;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-72086;Reactome: R-HSA-73779;Reactome: R-HSA-167246;Reactome: R-HSA-6781827;Reactome: R-HSA-75955 "RNA Polymerase I Transcription Termination";"TP53 Regulates Transcription of DNA Repair Genes";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Formation of Incision Complex in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Dual incision in TC-NER";"Formation of RNA Pol II elongation complex";"Cyclin D associated events in G1";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Cyclin A:Cdk2-associated events at S phase entry";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Promoter Escape";"Cyclin E associated events during G1/S transition";"RNA Polymerase II HIV Promoter Escape";"Cyclin A/B1/B2 associated events during G2/M transition";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"mRNA Capping";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Tat-mediated elongation of the HIV-1 transcript";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II Transcription Elongation" lcl|NW_020311955.1_prot_XP_020711183.1_12401 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311932.1_prot_XP_012257422.1_10719 6 KEGG: 00562+3.1.3.36;Reactome: R-HSA-194840;Reactome: R-HSA-1855183;Reactome: R-HSA-1855204;KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368 "Inositol phosphate metabolism";"Rho GTPase cycle";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation" lcl|NW_020311298.1_prot_XP_020706287.1_1348 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311424.1_prot_XP_012255409.1_8221 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311296.1_prot_XP_012265246.1_983 9 Reactome: R-HSA-1989781;Reactome: R-HSA-400206;Reactome: R-HSA-1368082;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-2151201;Reactome: R-HSA-1368108;Reactome: R-HSA-191859;Reactome: R-HSA-2426168 "PPARA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"RORA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"snRNP Assembly";"Activation of gene expression by SREBF (SREBP)" lcl|NW_020311426.1_prot_XP_012268557.1_8250 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311349.1_prot_XP_020710142.1_5163 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311941.1_prot_XP_020707060.1_11447 2 MetaCyc: PWY-7799;MetaCyc: PWY-7802 "Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)" lcl|NW_020311433.1_prot_XP_020710687.1_8651 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" lcl|NW_020311308.1_prot_XP_012253335.1_2228 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311988.1_prot_XP_020709740.1_20711 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" lcl|NW_020311945.1_prot_XP_012269657.1_11816 13 KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;KEGG: 00720+6.3.4.3;MetaCyc: PWY-5030;Reactome: R-HSA-196757;MetaCyc: PWY-1722;KEGG: 00670+1.5.1.5+3.5.4.9;KEGG: 00670+6.3.4.3;MetaCyc: PWY-7909;MetaCyc: PWY-2161;MetaCyc: PWY-2201;MetaCyc: PWY-6613;MetaCyc: PWY-5497 "Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"L-histidine degradation III";"Metabolism of folate and pterines";"Formate assimilation into 5,10-methylenetetrahydrofolate";"One carbon pool by folate";"One carbon pool by folate";"Formaldehyde oxidation VII (THF pathway)";"Folate polyglutamylation";"Folate transformations I";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine nucleobases degradation II (anaerobic)" lcl|NW_020311941.1_prot_XP_012253227.1_11449 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311974.1_prot_XP_012259795.1_16735 6 MetaCyc: PWY-7442;MetaCyc: PWY-5497;KEGG: 00230+3.5.4.3;MetaCyc: PWY-6608;Reactome: R-HSA-74259;MetaCyc: PWY-6606 "Drosopterin and aurodrosopterin biosynthesis";"Purine nucleobases degradation II (anaerobic)";"Purine metabolism";"Guanosine nucleotides degradation III";"Purine catabolism";"Guanosine nucleotides degradation II" lcl|NW_020311976.1_prot_XP_012253520.1_17330 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" lcl|NW_020311978.1_prot_XP_012258032.1_18478 52 Reactome: R-HSA-5689880;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610785;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-5610780;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-69601;Reactome: R-HSA-5607764 "Ub-specific processing proteases";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"GLI3 is processed to GLI3R by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI1 by the proteasome";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Neddylation";"Degradation of AXIN";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RAS by GAPs";"G2/M Checkpoints";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling" lcl|NW_020311401.1_prot_XP_012254994.1_7500 8 Reactome: R-HSA-180024;Reactome: R-HSA-442720;Reactome: R-HSA-381676;Reactome: R-HSA-432040;Reactome: R-HSA-983231;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-163615 "DARPP-32 events";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Vasopressin regulates renal water homeostasis via Aquaporins";"Factors involved in megakaryocyte development and platelet production";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"PKA activation" lcl|NW_020311365.1_prot_XP_020709378.1_5949 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311977.1_prot_XP_012264058.1_17676 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" lcl|NW_020311990.1_prot_XP_012266598.1_20837 2 Reactome: R-HSA-71336;KEGG: 00710+2.7.1.14 "Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms" lcl|NW_020311343.1_prot_XP_020708747.1_4787 3 Reactome: R-HSA-6798695;Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311309.1_prot_XP_012259054.1_2323 13 Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination" lcl|NW_020311373.1_prot_XP_020710378.1_6406 1 Reactome: R-HSA-111957 "Cam-PDE 1 activation" lcl|NW_020311290.1_prot_XP_012268978.1_450 17 KEGG: 00760+2.4.2.1;MetaCyc: PWY-6627;MetaCyc: PWY-7179;MetaCyc: PWY-5532;MetaCyc: PWY-6608;MetaCyc: PWY-6644;Reactome: R-HSA-74259;MetaCyc: PWY-6611;MetaCyc: PWY-5695;Reactome: R-HSA-74217;Reactome: R-HSA-6798695;KEGG: 00230+2.4.2.1;MetaCyc: PWY-7179-1;MetaCyc: PWY-6609;MetaCyc: PWY-4202;KEGG: 00240+2.4.2.1;MetaCyc: PWY-6620 "Nicotinate and nicotinamide metabolism";"Salinosporamide A biosynthesis";"Purine deoxyribonucleosides degradation I";"Nucleoside and nucleotide degradation (archaea)";"Guanosine nucleotides degradation III";"Fluoroacetate and fluorothreonine biosynthesis";"Purine catabolism";"Adenine and adenosine salvage V";"Inosine 5'-phosphate degradation";"Purine salvage";"Neutrophil degranulation";"Purine metabolism";"Purine deoxyribonucleosides degradation II";"Adenine and adenosine salvage III";"Arsenate detoxification I (mammalian)";"Pyrimidine metabolism";"Guanine and guanosine salvage" lcl|NW_020311308.1_prot_XP_012264420.1_2194 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311985.1_prot_XP_012265250.1_20204 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311917.1_prot_XP_012250934.1_10215 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311300.1_prot_XP_012253240.1_1493 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311973.1_prot_XP_012258634.1_16483 1 Reactome: R-HSA-201681 "TCF dependent signaling in response to WNT" lcl|NW_020311977.1_prot_XP_012264021.1_17958 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311513.1_prot_XP_012265975.1_9697 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311988.1_prot_XP_012268428.1_20641 13 Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation" lcl|NW_020311976.1_prot_XP_012253547.1_17275 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311432.1_prot_XP_012268621.1_8380 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311992.1_prot_XP_012266359.1_21144 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311292.1_prot_XP_020710265.1_691 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-5576892 "NCAM1 interactions";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation" lcl|NW_020311300.1_prot_XP_012253150.1_1503 7 Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942 "Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition" lcl|NW_020311977.1_prot_XP_012263924.1_17857 6 MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84 "Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis" lcl|NW_020311918.1_prot_XP_012265114.1_10312 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311918.1_prot_XP_012265065.1_10408 16 Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-141430;Reactome: R-HSA-179409;Reactome: R-HSA-176408;Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-174048;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-8853884 "Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC-Cdc20 mediated degradation of Nek2A";"Regulation of APC/C activators between G1/S and early anaphase";"Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Cyclin B";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Transcriptional Regulation by VENTX" lcl|NW_020311374.1_prot_XP_012264567.1_6520 2 Reactome: R-HSA-194840;Reactome: R-HSA-8876198 "Rho GTPase cycle";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311985.1_prot_XP_020707350.1_20293 9 MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5744;Reactome: R-HSA-1475029;MetaCyc: PWY-7115;MetaCyc: PWY-241;MetaCyc: PWY-7117 "3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"Glyoxylate assimilation";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type" lcl|NW_020311313.1_prot_XP_020709883.1_2847 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311321.1_prot_XP_012263246.1_3435 2 Reactome: R-HSA-2682334;Reactome: R-HSA-3928665 "EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells" lcl|NW_020311959.1_prot_XP_020707485.1_13207 1 Reactome: R-HSA-525793 "Myogenesis" lcl|NW_020311933.1_prot_XP_012252874.1_10758 3 Reactome: R-HSA-6807878;Reactome: R-HSA-162658;Reactome: R-HSA-204005 "COPI-mediated anterograde transport";"Golgi Cisternae Pericentriolar Stack Reorganization";"COPII-mediated vesicle transport" lcl|NW_020311364.1_prot_XP_012258906.1_5903 6 KEGG: 00040+1.1.1.22;MetaCyc: PWY-7820;Reactome: R-HSA-173599;KEGG: 00520+1.1.1.22;MetaCyc: PWY-7346;KEGG: 00053+1.1.1.22 "Pentose and glucuronate interconversions";"Teichuronic acid biosynthesis (B. subtilis 168)";"Formation of the active cofactor, UDP-glucuronate";"Amino sugar and nucleotide sugar metabolism";"UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)";"Ascorbate and aldarate metabolism" lcl|NW_020311965.1_prot_XP_012259975.1_14218 5 MetaCyc: PWY-7919;Reactome: R-HSA-4793954;Reactome: R-HSA-532668;KEGG: 00510+3.2.1.106;MetaCyc: PWY-7918 "Protein N-glycosylation processing phase (plants and animals)";"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"N-Glycan biosynthesis";"Protein N-glycosylation processing phase (yeast)" lcl|NW_020311463.1_prot_XP_020709111.1_9230 12 KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7409;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-6803;MetaCyc: PWY-8051 "alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Ether lipid metabolism";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Plasmalogen degradation";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I" lcl|NW_020311933.1_prot_XP_012252844.1_10768 1 Reactome: R-HSA-499943 "Interconversion of nucleotide di- and triphosphates" lcl|NW_020311320.1_prot_XP_012268076.1_3394 4 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-76071 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" lcl|NW_020311971.1_prot_XP_012260834.1_15904 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" lcl|NW_020311343.1_prot_XP_012258467.1_4837 5 Reactome: R-HSA-1362409;Reactome: R-HSA-2395516;Reactome: R-HSA-211976;Reactome: R-HSA-5579026;Reactome: R-HSA-196108 "Mitochondrial iron-sulfur cluster biogenesis";"Electron transport from NADPH to Ferredoxin";"Endogenous sterols";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Pregnenolone biosynthesis" lcl|NW_020311979.1_prot_XP_012261416.1_18687 7 Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311333.1_prot_XP_012256013.1_4306 1 Reactome: R-HSA-3000471 "Scavenging by Class B Receptors" lcl|NW_020311984.1_prot_XP_012267739.1_20119 14 Reactome: R-HSA-5696400;Reactome: R-HSA-5656121;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-5655862;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-69091;Reactome: R-HSA-5696397;Reactome: R-HSA-110320 "Dual Incision in GG-NER";"Translesion synthesis by POLI";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Polymerase switching";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion Synthesis by POLH" lcl|NW_020311971.1_prot_XP_012260961.1_15911 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311340.1_prot_XP_012258147.1_4693 2 Reactome: R-HSA-1483148;Reactome: R-HSA-1483166 "Synthesis of PG";"Synthesis of PA" lcl|NW_020311971.1_prot_XP_020709624.1_15989 2 Reactome: R-HSA-3769402;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex" lcl|NW_020311475.1_prot_XP_012253314.1_9393 16 Reactome: R-HSA-388841;Reactome: R-HSA-1266695;Reactome: R-HSA-9009391;Reactome: R-HSA-512988;Reactome: R-HSA-912631;Reactome: R-HSA-912526;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-8853659;Reactome: R-HSA-416476;Reactome: R-HSA-389357;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558;Reactome: R-HSA-1257604;Reactome: R-HSA-1660499;Reactome: R-HSA-1433557 "Costimulation by the CD28 family";"Interleukin-7 signaling";"Extra-nuclear estrogen signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of signaling by CBL";"Interleukin receptor SHC signaling";"Rho GTPase cycle";"GPVI-mediated activation cascade";"RET signaling";"G alpha (q) signalling events";"CD28 dependent PI3K/Akt signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"PIP3 activates AKT signaling";"Synthesis of PIPs at the plasma membrane";"Signaling by SCF-KIT" lcl|NW_020311943.1_prot_XP_012255052.1_11575 1 Reactome: R-HSA-196819 "Vitamin B1 (thiamin) metabolism" lcl|NW_020311957.1_prot_XP_012263397.2_12821 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" lcl|NW_020311966.1_prot_XP_012257395.1_14446 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" lcl|NW_020311988.1_prot_XP_012259961.1_20574 5 MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+2.7.7.18;MetaCyc: PWY-5653;MetaCyc: PWY-5381 "NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)" lcl|NW_020311346.1_prot_XP_012268475.1_5032 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311313.1_prot_XP_020709965.1_2940 5 Reactome: R-HSA-196757;MetaCyc: PWY-6614;KEGG: 00670+1.5.1.3;KEGG: 00790+1.5.1.3;MetaCyc: PWY-3841 "Metabolism of folate and pterines";"Tetrahydrofolate biosynthesis";"One carbon pool by folate";"Folate biosynthesis";"Folate transformations II (plants)" lcl|NW_020311973.1_prot_XP_012258610.1_16597 1 Reactome: R-HSA-8964038 "LDL clearance" lcl|NW_020311958.1_prot_XP_012254940.1_12948 7 Reactome: R-HSA-6814122;Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-5620922;Reactome: R-HSA-390450;Reactome: R-HSA-6798695;Reactome: R-HSA-389957 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"BBSome-mediated cargo-targeting to cilium";"Folding of actin by CCT/TriC";"Neutrophil degranulation";"Prefoldin mediated transfer of substrate to CCT/TriC" lcl|NW_020311980.1_prot_XP_012254907.1_18704 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311959.1_prot_XP_012262410.1_13068 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" lcl|NW_020311326.1_prot_XP_012261533.1_3732 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311969.1_prot_XP_012264750.1_15528 2 Reactome: R-HSA-196819;KEGG: 00230+4.6.1.1 "Vitamin B1 (thiamin) metabolism";"Purine metabolism" lcl|NW_020311946.1_prot_XP_012268770.1_11891 16 Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-179409;Reactome: R-HSA-176408;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-174154;Reactome: R-HSA-2559582;Reactome: R-HSA-8853884;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-174048 "Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A";"Regulation of APC/C activators between G1/S and early anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Securin";"Senescence-Associated Secretory Phenotype (SASP)";"Transcriptional Regulation by VENTX";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Cyclin B" lcl|NW_020311326.1_prot_XP_012261537.1_3747 16 Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-975956 "Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" lcl|NW_020311940.1_prot_XP_020711257.1_11280 3 MetaCyc: PWY-7799;MetaCyc: PWY-7800;Reactome: R-HSA-2514859 "Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway";"Inactivation, recovery and regulation of the phototransduction cascade" lcl|NW_020311940.1_prot_XP_020711261.1_11237 3 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.14;Reactome: R-HSA-379726 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" lcl|NW_020311964.1_prot_XP_025602539.1_13911 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311977.1_prot_XP_025602766.1_17925 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311365.1_prot_XP_020712488.1_5991 4 Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862 "NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants" lcl|NW_020311326.1_prot_XP_012261525.1_3726 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311988.1_prot_XP_012260096.1_20577 3 Reactome: R-HSA-8957275;Reactome: R-HSA-381038;Reactome: R-HSA-381426 "Post-translational protein phosphorylation";"XBP1(S) activates chaperone genes";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" lcl|NW_020311976.1_prot_XP_012253542.1_17268 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311293.1_prot_XP_012251480.1_851 2 Reactome: R-HSA-2299718;Reactome: R-HSA-2514853 "Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes" lcl|NW_020311980.1_prot_XP_012261273.1_18766 2 Reactome: R-HSA-430039;Reactome: R-HSA-72163 "mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway" lcl|NW_020311306.1_prot_XP_012264212.1_2103 56 Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610785;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-1236978;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-5668541 "Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Interleukin-1 signaling";"Degradation of DVL";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"GLI3 is processed to GLI3R by the proteasome";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Neddylation";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Regulation of RAS by GAPs";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"TNFR2 non-canonical NF-kB pathway" lcl|NW_020311995.1_prot_XP_012256815.1_21931 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311971.1_prot_XP_025602665.1_15858 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311983.1_prot_XP_012255670.1_19700 33 Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-3371453;Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-170822;Reactome: R-HSA-168325;Reactome: R-HSA-159227;Reactome: R-HSA-180746;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-5663220;Reactome: R-HSA-1169408;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-9648025;Reactome: R-HSA-165054;Reactome: R-HSA-180910;Reactome: R-HSA-4551638;Reactome: R-HSA-68877;Reactome: R-HSA-6784531;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-2500257;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-3301854;Reactome: R-HSA-2467813;Reactome: R-HSA-4615885;Reactome: R-HSA-191859;Reactome: R-HSA-5578749 "SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Regulation of HSF1-mediated heat shock response";"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Viral Messenger RNA Synthesis";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"RHO GTPases Activate Formins";"ISG15 antiviral mechanism";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"EML4 and NUDC in mitotic spindle formation";"Rev-mediated nuclear export of HIV RNA";"Vpr-mediated nuclear import of PICs";"SUMOylation of chromatin organization proteins";"Mitotic Prometaphase";"tRNA processing in the nucleus";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Resolution of Sister Chromatid Cohesion";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Nuclear Pore Complex (NPC) Disassembly";"Separation of Sister Chromatids";"SUMOylation of DNA replication proteins";"snRNP Assembly";"Transcriptional regulation by small RNAs" lcl|NW_020311977.1_prot_XP_012264034.1_17892 5 Reactome: R-HSA-1912420;Reactome: R-HSA-1912408;Reactome: R-HSA-350054;Reactome: R-HSA-5083630;Reactome: R-HSA-1912399 "Pre-NOTCH Processing in Golgi";"Pre-NOTCH Transcription and Translation";"Notch-HLH transcription pathway";"Defective LFNG causes SCDO3";"Pre-NOTCH Processing in the Endoplasmic Reticulum" lcl|NW_020311368.1_prot_XP_020710848.1_6216 4 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"DARPP-32 events" lcl|NW_020311988.1_prot_XP_012260188.1_20576 3 Reactome: R-HSA-381426;Reactome: R-HSA-381038;Reactome: R-HSA-8957275 "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"XBP1(S) activates chaperone genes";"Post-translational protein phosphorylation" lcl|NW_020311973.1_prot_XP_012258640.1_16569 1 Reactome: R-HSA-186797 "Signaling by PDGF" lcl|NW_020311966.1_prot_XP_020708242.1_14731 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311991.1_prot_XP_012269748.1_20929 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311373.1_prot_XP_025601918.1_6422 7 Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;MetaCyc: PWY-7511;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-9013507 "NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus" lcl|NW_020311965.1_prot_XP_012259865.1_14179 2 KEGG: 00900+2.5.1.58;Reactome: R-HSA-2514859 "Terpenoid backbone biosynthesis";"Inactivation, recovery and regulation of the phototransduction cascade" lcl|NW_020311300.1_prot_XP_020707081.1_1588 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311907.1_prot_XP_012264865.1_10144 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311346.1_prot_XP_012268613.1_5020 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311432.1_prot_XP_012268840.1_8356 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311500.1_prot_XP_012260033.1_9584 56 Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-174184;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-349425;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-180534;Reactome: R-HSA-8948751 "Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Regulation of RAS by GAPs";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Autodegradation of the E3 ubiquitin ligase COP1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ub-specific processing proteases";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity" lcl|NW_020311339.1_prot_XP_012254013.1_4610 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" lcl|NW_020311424.1_prot_XP_012255430.1_8236 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" lcl|NW_020311978.1_prot_XP_020708672.1_18122 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311976.1_prot_XP_012253512.1_17292 2 Reactome: R-HSA-8876198;Reactome: R-HSA-6811436 "RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311311.1_prot_XP_012250831.1_2544 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311332.1_prot_XP_012256843.1_4201 5 Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes" lcl|NW_020311309.1_prot_XP_020709060.1_2370 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311943.1_prot_XP_012255150.1_11640 3 KEGG: 00250+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00460+3.5.1.1 "Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism";"Cyanoamino acid metabolism" lcl|NW_020311977.1_prot_XP_012263939.1_17757 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311397.1_prot_XP_020707299.1_7352 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311418.1_prot_XP_012261053.1_8023 3 Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300 "SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors" lcl|NW_020311432.1_prot_XP_012268796.1_8503 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" lcl|NW_020311357.1_prot_XP_012266994.1_5600 10 Reactome: R-HSA-2453864;Reactome: R-HSA-975634;MetaCyc: PWY-5691;KEGG: 00230+3.5.2.17;MetaCyc: PWY-7849;Reactome: R-HSA-3000171;Reactome: R-HSA-6798695;MetaCyc: PWY-7394;Reactome: R-HSA-2453902;Reactome: R-HSA-977225 "Retinoid cycle disease events";"Retinoid metabolism and transport";"Urate conversion to allantoin I";"Purine metabolism";"Urate conversion to allantoin III";"Non-integrin membrane-ECM interactions";"Neutrophil degranulation";"Urate conversion to allantoin II";"The canonical retinoid cycle in rods (twilight vision)";"Amyloid fiber formation" lcl|NW_020311286.1_prot_XP_012256853.1_61 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311979.1_prot_XP_012261446.1_18678 3 KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1 "Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis" lcl|NW_020311373.1_prot_XP_020711640.1_6460 8 KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Signaling by Hippo";"Relaxin signaling pathway";"Thermogenesis" lcl|NW_020311940.1_prot_XP_012265587.1_11221 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" lcl|NW_020311980.1_prot_XP_012261331.1_18781 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311377.1_prot_XP_012268461.1_6578 6 Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-4086398;Reactome: R-HSA-8951430;Reactome: R-HSA-4411364 "Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"Ca2+ pathway";"RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters" lcl|NW_020311981.1_prot_XP_012257458.1_19072 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311353.1_prot_XP_012255914.1_5433 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311995.1_prot_XP_020708162.1_22033 9 Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-167161 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation" lcl|NW_020311959.1_prot_XP_012260469.1_13040 2 Reactome: R-HSA-5633231;Reactome: R-HSA-446193 "Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" lcl|NW_020311313.1_prot_XP_012261691.1_3032 1 Reactome: R-HSA-419771 "Opsins" lcl|NW_020311477.1_prot_XP_012262348.1_9448 4 KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614 "Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I";"Drug metabolism - other enzymes";"Pyrimidine salvage" lcl|NW_020311983.1_prot_XP_012267222.1_19496 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" lcl|NW_020311980.1_prot_XP_012261377.1_18846 2 Reactome: R-HSA-917729;Reactome: R-HSA-162588 "Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion" lcl|NW_020311965.1_prot_XP_012259398.1_14384 4 Reactome: R-HSA-6787450;Reactome: R-HSA-6782315;KEGG: 00908+2.5.1.75;MetaCyc: PWY-2781 "tRNA modification in the mitochondrion";"tRNA modification in the nucleus and cytosol";"Zeatin biosynthesis";"Cis-zeatin biosynthesis" lcl|NW_020311433.1_prot_XP_012264003.1_8613 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" lcl|NW_020311978.1_prot_XP_012258092.1_18129 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311971.1_prot_XP_012263557.1_16114 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311991.1_prot_XP_020706214.1_20914 8 KEGG: 00240+2.7.4.9;MetaCyc: PWY-7184;Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7210;MetaCyc: PWY-7187;MetaCyc: PWY-7197;MetaCyc: PWY-7198 "Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV" lcl|NW_020311306.1_prot_XP_012264213.1_2107 2 Reactome: R-HSA-8876198;Reactome: R-HSA-8873719 "RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation" lcl|NW_020311973.1_prot_XP_012258613.1_16606 8 MetaCyc: PWY-7181;Reactome: R-HSA-73614;Reactome: R-HSA-6798695;MetaCyc: PWY-7193;KEGG: 00983+3.5.4.5;MetaCyc: PWY-6556;MetaCyc: PWY-7199;KEGG: 00240+3.5.4.5 "Pyrimidine deoxyribonucleosides degradation";"Pyrimidine salvage";"Neutrophil degranulation";"Pyrimidine ribonucleosides salvage I";"Drug metabolism - other enzymes";"Pyrimidine ribonucleosides salvage II";"Pyrimidine deoxyribonucleosides salvage";"Pyrimidine metabolism" lcl|NW_020311286.1_prot_XP_012256323.1_137 4 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.17;MetaCyc: PWY-5188;KEGG: 00860+6.1.1.17 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism" lcl|NW_020311298.1_prot_XP_012269859.1_1345 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311941.1_prot_XP_012253298.1_11405 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311958.1_prot_XP_020707811.1_12978 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311304.1_prot_XP_012260898.1_1768 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" lcl|NW_020311423.1_prot_XP_012251566.1_8167 6 MetaCyc: PWY-5067;Reactome: R-HSA-189085;KEGG: 00500+3.2.1.1;MetaCyc: PWY-7900;MetaCyc: PWY-622;KEGG: 00500+2.4.1.18 "Glycogen biosynthesis II (from UDP-D-Glucose)";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch biosynthesis";"Starch and sucrose metabolism" lcl|NW_020311391.1_prot_XP_012256249.1_7034 57 Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-6798695;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-5689880;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-1236978;Reactome: R-HSA-69017;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553 "Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Neutrophil degranulation";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ub-specific processing proteases";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"G2/M Checkpoints";"Regulation of RAS by GAPs";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311389.1_prot_XP_012250649.1_7002 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311977.1_prot_XP_012263929.1_17813 14 Reactome: R-HSA-1474228;Reactome: R-HSA-1251985;Reactome: R-HSA-6798695;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-977225;Reactome: R-HSA-9017802;Reactome: R-HSA-9013700;Reactome: R-HSA-2894862;Reactome: R-HSA-205043;Reactome: R-HSA-2644606;Reactome: R-HSA-193692;Reactome: R-HSA-3928665 "Degradation of the extracellular matrix";"Nuclear signaling by ERBB4";"Neutrophil degranulation";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Amyloid fiber formation";"Noncanonical activation of NOTCH3";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NRIF signals cell death from the nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulated proteolysis of p75NTR";"EPH-ephrin mediated repulsion of cells" lcl|NW_020311334.1_prot_XP_020711367.1_4371 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" lcl|NW_020311939.1_prot_XP_012263609.1_11050 2 Reactome: R-HSA-983168;Reactome: R-HSA-110320 "Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH" lcl|NW_020311334.1_prot_XP_025601753.1_4345 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311985.1_prot_XP_012265281.1_20257 6 Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656 "Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311372.1_prot_XP_012268486.1_6337 2 Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5 "Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis" lcl|NW_020311987.1_prot_XP_020709153.1_20453 5 Reactome: R-HSA-1989781;Reactome: R-HSA-381183;Reactome: R-HSA-380994;Reactome: R-HSA-2426168;Reactome: R-HSA-9614657 "PPARA activates gene expression";"ATF6 (ATF6-alpha) activates chaperone genes";"ATF4 activates genes in response to endoplasmic reticulum stress";"Activation of gene expression by SREBF (SREBP)";"FOXO-mediated transcription of cell death genes" lcl|NW_020311972.1_prot_XP_012264459.1_16290 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" lcl|NW_020311360.1_prot_XP_012251637.1_5765 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311973.1_prot_XP_012258659.1_16581 7 Reactome: R-HSA-3000171;Reactome: R-HSA-5083629;Reactome: R-HSA-3000178;Reactome: R-HSA-5083633;Reactome: R-HSA-5083628;Reactome: R-HSA-5173105;Reactome: R-HSA-9010553 "Non-integrin membrane-ECM interactions";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"ECM proteoglycans";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"O-linked glycosylation";"Regulation of expression of SLITs and ROBOs" lcl|NW_020311461.1_prot_XP_020712445.1_9200 3 Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.5;Reactome: R-HSA-379716 "Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" lcl|NW_020311287.1_prot_XP_012268063.1_293 3 Reactome: R-HSA-1650814;MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2 "Collagen biosynthesis and modifying enzymes";"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism" lcl|NW_020311953.1_prot_XP_012260523.1_12259 6 MetaCyc: PWY-5067;Reactome: R-HSA-1362409;Reactome: R-HSA-1268020;Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.11;KEGG: 00860+1.16.3.1 "Glycogen biosynthesis II (from UDP-D-Glucose)";"Mitochondrial iron-sulfur cluster biogenesis";"Mitochondrial protein import";"Glycogen synthesis";"Starch and sucrose metabolism";"Porphyrin and chlorophyll metabolism" lcl|NW_020311983.1_prot_XP_012267172.1_19526 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311917.1_prot_XP_012250984.1_10248 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311359.1_prot_XP_012252061.1_5715 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311976.1_prot_XP_012257125.1_17364 1 Reactome: R-HSA-203927 "MicroRNA (miRNA) biogenesis" lcl|NW_020311987.1_prot_XP_020712071.1_20418 3 MetaCyc: PWY-5963;KEGG: 00790+2.8.1.9;Reactome: R-HSA-947581 "Thio-molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis" lcl|NW_020311946.1_prot_XP_012268747.1_11900 8 KEGG: 00052+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171 "Galactose metabolism";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Glycolysis" lcl|NW_020311321.1_prot_XP_020710393.1_3438 2 Reactome: R-HSA-2682334;Reactome: R-HSA-3928665 "EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells" lcl|NW_020311942.1_prot_XP_012252456.1_11456 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" lcl|NW_020311298.1_prot_XP_012269919.1_1263 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311940.1_prot_XP_012265578.1_11215 7 MetaCyc: PWY-7238;MetaCyc: PWY-6724;Reactome: R-HSA-6798695;Reactome: R-HSA-70221;MetaCyc: PWY-5941;MetaCyc: PWY-6737;KEGG: 00500+2.4.1.25 "Sucrose biosynthesis II";"Starch degradation II";"Neutrophil degranulation";"Glycogen breakdown (glycogenolysis)";"Glycogen degradation II";"Starch degradation V";"Starch and sucrose metabolism" lcl|NW_020311964.1_prot_XP_025602510.1_13950 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311948.1_prot_XP_012253433.1_12009 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" lcl|NW_020311984.1_prot_XP_012264716.1_19830 13 MetaCyc: PWY-7112;KEGG: 00983+2.5.1.18;Reactome: R-HSA-196836;MetaCyc: PWY-7533;Reactome: R-HSA-156590;MetaCyc: PWY-6842;KEGG: 00053+1.8.5.1;MetaCyc: PWY-6370;KEGG: 00980+2.5.1.18;MetaCyc: PWY-2261;MetaCyc: PWY-4061;KEGG: 00480+2.5.1.18+1.8.5.1;KEGG: 00982+2.5.1.18 "4-hydroxy-2-nonenal detoxification";"Drug metabolism - other enzymes";"Vitamin C (ascorbate) metabolism";"Gliotoxin biosynthesis";"Glutathione conjugation";"Glutathione-mediated detoxification II";"Ascorbate and aldarate metabolism";"Ascorbate recycling (cytosolic)";"Metabolism of xenobiotics by cytochrome P450";"Ascorbate glutathione cycle";"Glutathione-mediated detoxification I";"Glutathione metabolism";"Drug metabolism - cytochrome P450" lcl|NW_020311966.1_prot_XP_012257161.1_15041 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311479.1_prot_XP_012253349.1_9459 6 Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72689 "Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits" lcl|NW_020311972.1_prot_XP_012264746.1_16309 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311298.1_prot_XP_020706267.1_1357 1 Reactome: R-HSA-9603798 "Class I peroxisomal membrane protein import" lcl|NW_020311408.1_prot_XP_012262105.1_7806 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311965.1_prot_XP_020709432.1_14142 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311993.1_prot_XP_012263223.1_21348 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" lcl|NW_020311337.1_prot_XP_012251796.1_4440 10 KEGG: 00562+2.7.1.153;KEGG: 05170+2.7.1.153;MetaCyc: PWY-6352;KEGG: 04150+2.7.1.153;KEGG: 04151+2.7.1.153;Reactome: R-HSA-9027276;Reactome: R-HSA-1660499;KEGG: 05163+2.7.1.153;KEGG: 04070+2.7.1.153;KEGG: 05165+2.7.1.153 "Inositol phosphate metabolism";"Human immunodeficiency virus 1 infection";"3-phosphoinositide biosynthesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"Synthesis of PIPs at the plasma membrane";"Human cytomegalovirus infection";"Phosphatidylinositol signaling system";"Human papillomavirus infection" lcl|NW_020311966.1_prot_XP_020706648.1_14571 3 Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369 "Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis" lcl|NW_020311966.1_prot_XP_025602568.1_14449 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" lcl|NW_020311326.1_prot_XP_012261517.1_3722 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311419.1_prot_XP_012254071.1_8063 15 Reactome: R-HSA-113418;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-167238;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-167242;Reactome: R-HSA-167152;Reactome: R-HSA-167158;Reactome: R-HSA-9603505 "Formation of the Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the HIV-1 Early Elongation Complex";"NTRK3 as a dependence receptor" lcl|NW_020311298.1_prot_XP_012269888.1_1342 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311993.1_prot_XP_012262969.1_21329 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311381.1_prot_XP_012252330.1_6830 14 Reactome: R-HSA-203927;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-426486;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-8948700;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944 "MicroRNA (miRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"Small interfering RNA (siRNA) biogenesis";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2" lcl|NW_020311472.1_prot_XP_012269232.1_9321 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311950.1_prot_XP_025602405.1_12181 1 Reactome: R-HSA-8876725 "Protein methylation" lcl|NW_020311402.1_prot_XP_012267028.1_7711 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311367.1_prot_XP_020709008.1_6075 3 Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-429947 "ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Deadenylation of mRNA" lcl|NW_020311341.1_prot_XP_012257969.1_4697 7 MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11;MetaCyc: PWY-6367;MetaCyc: PWY-6351;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052 "Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism";"D-myo-inositol-5-phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis" lcl|NW_020311941.1_prot_XP_012253299.1_11406 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311370.1_prot_XP_020710066.1_6264 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311943.1_prot_XP_012254970.1_11663 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311325.1_prot_XP_020706301.1_3680 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" lcl|NW_020311432.1_prot_XP_012268810.1_8422 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" lcl|NW_020311917.1_prot_XP_012250920.1_10219 5 MetaCyc: PWY-6527;MetaCyc: PWY-6317;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;KEGG: 00520+2.7.1.6 "Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"D-galactose detoxification";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311943.1_prot_XP_012254706.1_11703 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311308.1_prot_XP_020710854.1_2169 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" lcl|NW_020311401.1_prot_XP_012254937.1_7677 9 MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7883;KEGG: 00513+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52 "Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Glycosphingolipid biosynthesis - ganglio series";"Anhydromuropeptides recycling II";"Various types of N-glycan biosynthesis";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation" lcl|NW_020311393.1_prot_XP_020711291.1_7212 5 Reactome: R-HSA-1445148;Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-75035 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" lcl|NW_020311983.1_prot_XP_012255593.1_19667 2 Reactome: R-HSA-2142700;Reactome: R-HSA-2142691 "Synthesis of Lipoxins (LX)";"Synthesis of Leukotrienes (LT) and Eoxins (EX)" lcl|NW_020311298.1_prot_XP_012269898.1_1232 5 KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00561+3.2.1.22 "Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism";"Stachyose degradation";"Glycerolipid metabolism" lcl|NW_020311977.1_prot_XP_012252246.1_17469 16 Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012 "Translation initiation complex formation";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency" lcl|NW_020311302.1_prot_XP_012264554.1_1670 3 MetaCyc: PWY-7831;MetaCyc: PWY-7833;Reactome: R-HSA-9033807 "ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide";"Biosynthesis of Lewis epitopes (H. pylori)";"ABO blood group biosynthesis" lcl|NW_020311991.1_prot_XP_012269728.1_20910 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311325.1_prot_XP_012253384.1_3695 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6798695 "COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation" lcl|NW_020311966.1_prot_XP_020707003.1_14391 6 KEGG: 00710+5.1.3.1;KEGG: 00040+5.1.3.1;MetaCyc: PWY-5723;Reactome: R-HSA-71336;MetaCyc: PWY-1861;KEGG: 00030+5.1.3.1 "Carbon fixation in photosynthetic organisms";"Pentose and glucuronate interconversions";"Rubisco shunt";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway" lcl|NW_020311918.1_prot_XP_012265039.1_10469 6 MetaCyc: PWY-5653;Reactome: R-HSA-196807;MetaCyc: PWY-5381;KEGG: 00760+6.3.1.5;MetaCyc: PWY-7761;KEGG: 00760+6.3.5.1 "NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate metabolism";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism" lcl|NW_020311992.1_prot_XP_012266427.1_21222 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311977.1_prot_XP_020707333.1_17502 1 Reactome: R-HSA-5649702 "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" lcl|NW_020311403.1_prot_XP_020708797.1_7733 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311984.1_prot_XP_012267783.1_20172 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311503.1_prot_XP_012255225.1_9608 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311971.1_prot_XP_012260946.1_15964 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311977.1_prot_XP_012263931.1_17817 1 Reactome: R-HSA-2151201 "Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311306.1_prot_XP_020710755.1_2047 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311316.1_prot_XP_020712354.1_3162 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" lcl|NW_020311955.1_prot_XP_020711143.1_12381 10 KEGG: 00520+5.1.3.2;KEGG: 00052+5.1.3.2;MetaCyc: PWY-7344;MetaCyc: PWY-7328;MetaCyc: PWY-6397;Reactome: R-HSA-70370;MetaCyc: PWY-3821;Reactome: R-HSA-5609977;MetaCyc: PWY-6317;MetaCyc: PWY-6527 "Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"UDP-alpha-D-galactose biosynthesis";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Galactose catabolism";"D-galactose detoxification";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation" lcl|NW_020311967.1_prot_XP_020707512.1_15282 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" lcl|NW_020311929.1_prot_XP_012255912.1_10655 2 Reactome: R-HSA-427413;Reactome: R-HSA-3214815 "NoRC negatively regulates rRNA expression";"HDACs deacetylate histones" lcl|NW_020311940.1_prot_XP_012265631.1_11159 3 KEGG: 00480+1.1.1.44;Reactome: R-HSA-71336;KEGG: 00030+1.1.1.44 "Glutathione metabolism";"Pentose phosphate pathway";"Pentose phosphate pathway" lcl|NW_020311304.1_prot_XP_012260708.1_1833 10 MetaCyc: PWY-6922;KEGG: 00332+1.2.1.41;KEGG: 00330+1.2.1.41;KEGG: 00330+2.7.2.11+1.2.1.41;KEGG: 00330+1.2.1.41+2.7.2.11;KEGG: 00332+2.7.2.11;KEGG: 00332+1.2.1.41+2.7.2.11;KEGG: 00330+2.7.2.11;Reactome: R-HSA-8964539;KEGG: 00332+2.7.2.11+1.2.1.41 "L-Ndelta-acetylornithine biosynthesis";"Carbapenem biosynthesis";"Arginine and proline metabolism";"Arginine and proline metabolism";"Arginine and proline metabolism";"Carbapenem biosynthesis";"Carbapenem biosynthesis";"Arginine and proline metabolism";"Glutamate and glutamine metabolism";"Carbapenem biosynthesis" lcl|NW_020311966.1_prot_XP_012252977.1_14537 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" lcl|NW_020311308.1_prot_XP_020710855.1_2170 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" lcl|NW_020311988.1_prot_XP_020712297.1_20583 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311974.1_prot_XP_012259933.1_16830 3 KEGG: 00785+2.3.1.181;MetaCyc: PWY-7382;MetaCyc: PWY-6987 "Lipoic acid metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoate biosynthesis and incorporation III (Bacillus)" lcl|NW_020311324.1_prot_XP_012269314.1_3555 1 MetaCyc: PWY-7942 "5-oxo-L-proline metabolism" lcl|NW_020311983.1_prot_XP_012268348.1_19605 2 Reactome: R-HSA-418594;Reactome: R-HSA-6814122 "G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" lcl|NW_020311312.1_prot_XP_012266745.1_2579 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311918.1_prot_XP_012268582.1_10308 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311979.1_prot_XP_012259373.1_18496 29 Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-76042;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-6781827;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-6796648;Reactome: R-HSA-73863;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-5696400 "HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER" lcl|NW_020311987.1_prot_XP_012256681.1_20376 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" lcl|NW_020311966.1_prot_XP_020708096.1_14801 1 Reactome: R-HSA-5689877 "Josephin domain DUBs" lcl|NW_020311967.1_prot_XP_012256015.1_15264 9 KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1;Reactome: R-HSA-198323 "Relaxin signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection";"AKT phosphorylates targets in the cytosol" lcl|NW_020311353.1_prot_XP_012256162.1_5414 6 MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782 "Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis" lcl|NW_020311433.1_prot_XP_020710703.1_8626 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311992.1_prot_XP_012266292.1_21044 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311971.1_prot_XP_012263506.1_16054 14 Reactome: R-HSA-5655862;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-69091;Reactome: R-HSA-110320;Reactome: R-HSA-5696400;Reactome: R-HSA-5656121;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169 "Translesion synthesis by POLK";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Polymerase switching";"Translesion Synthesis by POLH";"Dual Incision in GG-NER";"Translesion synthesis by POLI";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis" lcl|NW_020311298.1_prot_XP_012250629.1_1216 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" lcl|NW_020311327.1_prot_XP_020710432.1_3859 13 MetaCyc: PWY-7883;Reactome: R-HSA-2160916;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2024101;MetaCyc: PWY-7822;MetaCyc: PWY-6902;Reactome: R-HSA-2022857;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-1660662;KEGG: 00513+3.2.1.52 "Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation";"Glycosphingolipid biosynthesis - ganglio series";"CS/DS degradation";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Keratan sulfate degradation";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid metabolism";"Various types of N-glycan biosynthesis" lcl|NW_020311971.1_prot_XP_012263593.1_16063 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311992.1_prot_XP_012266363.1_21148 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" lcl|NW_020311365.1_prot_XP_012269358.1_5985 17 Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-6790901;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-72689 "SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits" lcl|NW_020311966.1_prot_XP_020708246.1_14764 6 KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508 "Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis" lcl|NW_020311349.1_prot_XP_020710143.1_5164 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311992.1_prot_XP_012266297.1_21218 16 Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339 "Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311397.1_prot_XP_020707304.1_7345 3 KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109;MetaCyc: PWY-4261 "Glycerolipid metabolism";"Triglyceride biosynthesis";"Glycerol degradation I" lcl|NW_020311973.1_prot_XP_020708847.1_16495 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" lcl|NW_020311975.1_prot_XP_020707379.1_17105 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311401.1_prot_XP_012254999.1_7496 13 Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823 "Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation" lcl|NW_020311347.1_prot_XP_012266157.1_5070 56 Reactome: R-HSA-5689880;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-5632684;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-350562;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-5607764;Reactome: R-HSA-69601 "Ub-specific processing proteases";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog 'on' state";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Interleukin-1 signaling";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"G2/M Checkpoints";"Regulation of RAS by GAPs";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A" lcl|NW_020311393.1_prot_XP_012265742.1_7193 1 Reactome: R-HSA-8949613 "Cristae formation" lcl|NW_020311356.1_prot_XP_012267113.1_5568 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311298.1_prot_XP_012250515.1_1139 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311426.1_prot_XP_012268515.1_8259 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157 "MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions" lcl|NW_020311539.1_prot_XP_012262786.1_9979 8 Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-156711 "Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Polo-like kinase mediated events" lcl|NW_020311945.1_prot_XP_012261709.1_11832 14 MetaCyc: PWY-7619;MetaCyc: PWY-5972;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7725;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-7724 "Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)" lcl|NW_020311326.1_prot_XP_012261522.1_3723 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311966.1_prot_XP_012257323.1_14827 2 Reactome: R-HSA-5663220;Reactome: R-HSA-376176 "RHO GTPases Activate Formins";"Signaling by ROBO receptors" lcl|NW_020311298.1_prot_XP_020706235.1_1144 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" lcl|NW_020311339.1_prot_XP_012253616.1_4655 6 Reactome: R-HSA-5654700;Reactome: R-HSA-5673001;Reactome: R-HSA-5654706;Reactome: R-HSA-5654693;Reactome: R-HSA-5654712;Reactome: R-HSA-9028731 "FRS-mediated FGFR2 signaling";"RAF/MAP kinase cascade";"FRS-mediated FGFR3 signaling";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR4 signaling";"Activated NTRK2 signals through FRS2 and FRS3" lcl|NW_020311979.1_prot_XP_012259370.1_18494 2 Reactome: R-HSA-5658442;Reactome: R-HSA-6802953 "Regulation of RAS by GAPs";"RAS signaling downstream of NF1 loss-of-function variants" lcl|NW_020311992.1_prot_XP_012266555.1_21263 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311676.1_prot_XP_025602237.1_10098 1 Reactome: R-HSA-196757 "Metabolism of folate and pterines" lcl|NW_020311338.1_prot_XP_012263093.1_4588 2 Reactome: R-HSA-2299718;Reactome: R-HSA-2514853 "Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes" lcl|NW_020311964.1_prot_XP_025602535.1_13908 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311292.1_prot_XP_020706839.1_595 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311391.1_prot_XP_025601966.1_7054 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311424.1_prot_XP_012255447.1_8188 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311953.1_prot_XP_020709488.1_12255 6 MetaCyc: PWY-8010;KEGG: 00750+2.6.1.52;KEGG: 00260+2.6.1.52;KEGG: 00270+2.6.1.52;KEGG: 00680+2.6.1.52;Reactome: R-HSA-977347 "L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Vitamin B6 metabolism";"Glycine, serine and threonine metabolism";"Cysteine and methionine metabolism";"Methane metabolism";"Serine biosynthesis" lcl|NW_020311978.1_prot_XP_012258064.1_18137 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311982.1_prot_XP_020708804.1_19341 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311326.1_prot_XP_025601722.1_3750 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311958.1_prot_XP_020708053.1_12991 13 Reactome: R-HSA-5607763;Reactome: R-HSA-2029485;Reactome: R-HSA-422356;Reactome: R-HSA-5578775;Reactome: R-HSA-2871809;Reactome: R-HSA-114508;Reactome: R-HSA-1489509;Reactome: R-HSA-112043;Reactome: R-HSA-5218921;Reactome: R-HSA-983695;Reactome: R-HSA-4086398;Reactome: R-HSA-381676;Reactome: R-HSA-139853 "CLEC7A (Dectin-1) induces NFAT activation";"Role of phospholipids in phagocytosis";"Regulation of insulin secretion";"Ion homeostasis";"FCERI mediated Ca+2 mobilization";"Effects of PIP2 hydrolysis";"DAG and IP3 signaling";"PLC beta mediated events";"VEGFR2 mediated cell proliferation";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Ca2+ pathway";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Elevation of cytosolic Ca2+ levels" lcl|NW_020311539.1_prot_XP_012262343.1_9991 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311300.1_prot_XP_012253166.1_1530 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311602.1_prot_XP_025602231.1_10067 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311323.1_prot_XP_020712038.1_3493 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311419.1_prot_XP_012254054.1_8086 5 KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7979;MetaCyc: PWY-7921 "Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)" lcl|NW_020311917.1_prot_XP_020706449.1_10242 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311350.1_prot_XP_020706621.1_5345 6 Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"RHO GTPases Activate Formins" lcl|NW_020311503.1_prot_XP_012255242.1_9610 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311419.1_prot_XP_012254057.1_8073 1 Reactome: R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" lcl|NW_020311982.1_prot_XP_012258127.1_19352 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311349.1_prot_XP_012262430.1_5162 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311315.1_prot_XP_012265151.2_3143 2 Reactome: R-HSA-212676;Reactome: R-HSA-181429 "Dopamine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle" lcl|NW_020311326.1_prot_XP_025603102.1_3721 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311401.1_prot_XP_020707758.1_7579 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311332.1_prot_XP_012268548.1_4139 1 KEGG: 00970+6.1.1.9 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311413.1_prot_XP_012254385.1_7908 56 Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-180585;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-8951664;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-69017;Reactome: R-HSA-1236978;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949 "CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Vif-mediated degradation of APOBEC3G";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Neddylation";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"G2/M Checkpoints";"Regulation of RAS by GAPs";"CDK-mediated phosphorylation and removal of Cdc6";"Cross-presentation of soluble exogenous antigens (endosomes)";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin" lcl|NW_020311988.1_prot_XP_012266762.1_20626 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311984.1_prot_XP_012267714.1_20140 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" lcl|NW_020311977.1_prot_XP_012252250.1_17477 7 Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-8950505;Reactome: R-HSA-390471;Reactome: R-HSA-5620922;Reactome: R-HSA-6814122;Reactome: R-HSA-389960 "Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Association of TriC/CCT with target proteins during biosynthesis";"BBSome-mediated cargo-targeting to cilium";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Formation of tubulin folding intermediates by CCT/TriC" lcl|NW_020311349.1_prot_XP_012251172.1_5233 7 MetaCyc: PWY-5921;KEGG: 00220+3.5.1.2;Reactome: R-HSA-8964539;Reactome: R-HSA-5628897;Reactome: R-HSA-210500;KEGG: 00250+3.5.1.2;KEGG: 00471+3.5.1.2 "Glutaminyl-trnagln biosynthesis via transamidation";"Arginine biosynthesis";"Glutamate and glutamine metabolism";"TP53 Regulates Metabolic Genes";"Glutamate Neurotransmitter Release Cycle";"Alanine, aspartate and glutamate metabolism";"D-Glutamine and D-glutamate metabolism" lcl|NW_020311932.1_prot_XP_012252995.1_10686 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311966.1_prot_XP_020706993.1_14431 6 MetaCyc: PWY-4381;MetaCyc: PWY-5743;MetaCyc: PWY-5744;MetaCyc: PWY-5789;Reactome: R-HSA-196780;MetaCyc: PWY-6722 "Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate cycle";"Glyoxylate assimilation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Biotin transport and metabolism";"Candicidin biosynthesis" lcl|NW_020311340.1_prot_XP_012269651.1_4682 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311966.1_prot_XP_012256821.1_15182 22 Reactome: R-HSA-5467337;Reactome: R-HSA-2467813;Reactome: R-HSA-5673000;Reactome: R-HSA-432142;Reactome: R-HSA-6811558;Reactome: R-HSA-5358752;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-5467340;Reactome: R-HSA-5339716;Reactome: R-HSA-5358749;Reactome: R-HSA-68877;Reactome: R-HSA-5675221;Reactome: R-HSA-4641262;Reactome: R-HSA-5358751;Reactome: R-HSA-196299;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-5358747;Reactome: R-HSA-5467348;Reactome: R-HSA-195253 "APC truncation mutants have impaired AXIN binding";"Separation of Sister Chromatids";"RAF activation";"Platelet sensitization by LDL";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"T41 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"AXIN missense mutants destabilize the destruction complex";"Misspliced GSK3beta mutants stabilize beta-catenin";"S37 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Negative regulation of MAPK pathway";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S45 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"S33 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex" lcl|NW_020311973.1_prot_XP_012258589.1_16359 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311312.1_prot_XP_020711648.1_2663 3 Reactome: R-HSA-975574;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.144 "Reactions specific to the hybrid N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis" lcl|NW_020311978.1_prot_XP_012257863.1_18095 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" lcl|NW_020311994.1_prot_XP_020711883.1_21603 4 Reactome: R-HSA-499943;MetaCyc: PWY-7221;Reactome: R-HSA-2161541;KEGG: 00230+2.7.4.8 "Interconversion of nucleotide di- and triphosphates";"Guanosine ribonucleotides de novo biosynthesis";"Abacavir metabolism";"Purine metabolism" lcl|NW_020311393.1_prot_XP_012265748.1_7153 7 KEGG: 00240+3.5.2.3;MetaCyc: PWY-7791;MetaCyc: PWY-5686;MetaCyc: PWY-7790;KEGG: 00230+3.5.2.5;MetaCyc: PWY-5698;MetaCyc: PWY-5697 "Pyrimidine metabolism";"UMP biosynthesis III";"UMP biosynthesis I";"UMP biosynthesis II";"Purine metabolism";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Allantoin degradation to ureidoglycolate I (urea producing)" lcl|NW_020311940.1_prot_XP_012265562.1_11194 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311370.1_prot_XP_020710071.1_6269 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311378.1_prot_XP_012260671.1_6623 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311917.1_prot_XP_012250978.1_10243 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311979.1_prot_XP_012259533.1_18607 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311433.1_prot_XP_012263635.1_8636 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311966.1_prot_XP_020708278.1_14824 2 Reactome: R-HSA-5663220;Reactome: R-HSA-376176 "RHO GTPases Activate Formins";"Signaling by ROBO receptors" lcl|NW_020311977.1_prot_XP_012263782.1_17702 24 Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-437239;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-8955332;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-1445148;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-190861;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-5617833;Reactome: R-HSA-3371497;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436 "RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"Recycling pathway of L1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"RHO GTPases Activate Formins";"Carboxyterminal post-translational modifications of tubulin";"Aggrephagy";"Separation of Sister Chromatids";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"Gap junction assembly";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Cilium Assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311439.1_prot_XP_025602106.1_8840 1 Reactome: R-HSA-5693607 "Processing of DNA double-strand break ends" lcl|NW_020311973.1_prot_XP_020708865.1_16362 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311975.1_prot_XP_025602714.1_16993 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311346.1_prot_XP_012262912.1_5003 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311994.1_prot_XP_020711843.1_21531 4 Reactome: R-HSA-4719360;Reactome: R-HSA-4719377;Reactome: R-HSA-4717374;Reactome: R-HSA-162699 "Defective DPM3 causes DPM3-CDG (CDG-1o)";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM1 causes DPM1-CDG (CDG-1e)";"Synthesis of dolichyl-phosphate mannose" lcl|NW_020311298.1_prot_XP_012250606.1_1371 1 Reactome: R-HSA-6790901 "rRNA modification in the nucleus and cytosol" lcl|NW_020311966.1_prot_XP_012256648.1_14683 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311403.1_prot_XP_025601999.1_7736 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311313.1_prot_XP_012261891.1_2820 1 KEGG: 00270+2.1.1.37 "Cysteine and methionine metabolism" lcl|NW_020311958.1_prot_XP_020708048.1_12989 13 Reactome: R-HSA-5607763;Reactome: R-HSA-2029485;Reactome: R-HSA-422356;Reactome: R-HSA-5578775;Reactome: R-HSA-2871809;Reactome: R-HSA-114508;Reactome: R-HSA-1489509;Reactome: R-HSA-112043;Reactome: R-HSA-5218921;Reactome: R-HSA-983695;Reactome: R-HSA-4086398;Reactome: R-HSA-381676;Reactome: R-HSA-139853 "CLEC7A (Dectin-1) induces NFAT activation";"Role of phospholipids in phagocytosis";"Regulation of insulin secretion";"Ion homeostasis";"FCERI mediated Ca+2 mobilization";"Effects of PIP2 hydrolysis";"DAG and IP3 signaling";"PLC beta mediated events";"VEGFR2 mediated cell proliferation";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Ca2+ pathway";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Elevation of cytosolic Ca2+ levels" lcl|NW_020311353.1_prot_XP_012255963.1_5462 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" lcl|NW_020311321.1_prot_XP_012263250.1_3436 2 Reactome: R-HSA-3928665;Reactome: R-HSA-2682334 "EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling" lcl|NW_020311966.1_prot_XP_020708236.1_14754 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311977.1_prot_XP_012264029.1_17954 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" lcl|NW_020311393.1_prot_XP_012265790.1_7199 2 Reactome: R-HSA-418457;Reactome: R-HSA-4086398 "cGMP effects";"Ca2+ pathway" lcl|NW_020311959.1_prot_XP_012259594.1_13176 4 Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" lcl|NW_020311934.1_prot_XP_012254850.1_10882 1 Reactome: R-HSA-1474151 "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" lcl|NW_020311298.1_prot_XP_012250555.1_1170 13 Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689 "Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits" lcl|NW_020311334.1_prot_XP_012265940.2_4338 3 Reactome: R-HSA-75109;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Triglyceride biosynthesis";"Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311959.1_prot_XP_020710106.1_13100 6 Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817 "Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)" lcl|NW_020311298.1_prot_XP_020706246.1_1229 5 MetaCyc: PWY-6527;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00052+3.2.1.22;KEGG: 00561+3.2.1.22 "Stachyose degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Galactose metabolism";"Glycerolipid metabolism" lcl|NW_020311982.1_prot_XP_012258438.1_19272 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311291.1_prot_XP_020709166.1_462 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" lcl|NW_020311977.1_prot_XP_025602762.1_17924 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311973.1_prot_XP_012258742.1_16375 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" lcl|NW_020311973.1_prot_XP_020708871.1_16365 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311965.1_prot_XP_012259949.1_14254 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" lcl|NW_020311962.1_prot_XP_020706684.1_13580 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311983.1_prot_XP_012255571.1_19656 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311966.1_prot_XP_012252947.1_14424 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311980.1_prot_XP_012261308.1_18863 4 KEGG: 00910+1.4.1.14;KEGG: 00250+1.4.1.14;Reactome: R-HSA-73621;MetaCyc: PWY-6963 "Nitrogen metabolism";"Alanine, aspartate and glutamate metabolism";"Pyrimidine catabolism";"Ammonia assimilation cycle I" lcl|NW_020311419.1_prot_XP_012254070.1_8062 15 Reactome: R-HSA-113418;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-9603505 "Formation of the Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"NTRK3 as a dependence receptor" lcl|NW_020311994.1_prot_XP_025603017.1_21508 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" lcl|NW_020311975.1_prot_XP_012253825.1_16975 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311992.1_prot_XP_020711550.1_21142 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311458.1_prot_XP_012264676.1_9159 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311978.1_prot_XP_012258069.1_18251 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311310.1_prot_XP_020707970.1_2439 5 Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902 "Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)" lcl|NW_020311973.1_prot_XP_012258633.1_16482 1 Reactome: R-HSA-201681 "TCF dependent signaling in response to WNT" lcl|NW_020311977.1_prot_XP_012263930.1_17816 1 Reactome: R-HSA-2151201 "Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311824.1_prot_XP_012265083.1_10108 1 Reactome: R-HSA-2151201 "Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311388.1_prot_XP_020710953.1_6998 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311417.1_prot_XP_012259113.1_7947 3 MetaCyc: PWY-5996;MetaCyc: PWY-5987;Reactome: R-HSA-75105 "Oleate biosynthesis II (animals and fungi)";"Sorgoleone biosynthesis";"Fatty acyl-CoA biosynthesis" lcl|NW_020311984.1_prot_XP_020711963.1_20088 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311462.1_prot_XP_012252265.1_9212 6 KEGG: 00730+2.7.6.2;MetaCyc: PWY-6898;MetaCyc: PWY-7356;MetaCyc: PWY-6907;MetaCyc: PWY-6908;Reactome: R-HSA-196819 "Thiamine metabolism";"Thiamine salvage III";"Thiamine salvage IV (yeast)";"Thiamine diphosphate biosynthesis III (Staphylococcus)";"Thiamine diphosphate biosynthesis IV (eukaryotes)";"Vitamin B1 (thiamin) metabolism" lcl|NW_020311955.1_prot_XP_012265388.1_12408 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" lcl|NW_020311979.1_prot_XP_025602812.1_18538 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311977.1_prot_XP_012263910.1_17726 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" lcl|NW_020311967.1_prot_XP_025602603.1_15249 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311966.1_prot_XP_012256811.1_15004 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311948.1_prot_XP_012253482.1_12023 7 Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-983168;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-3108214;MetaCyc: PWY-7511 "Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Antigen processing: Ubiquitination & Proteasome degradation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"SUMOylation of DNA damage response and repair proteins";"Protein ubiquitination" lcl|NW_020311955.1_prot_XP_012265393.1_12419 56 Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-5658442;Reactome: R-HSA-69481;Reactome: R-HSA-4641257;Reactome: R-HSA-9604323;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-8951664;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-180585;Reactome: R-HSA-174184;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-5610780;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610785;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-9010553;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-5610783;Reactome: R-HSA-8941858;Reactome: R-HSA-8939236;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-382556;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-349425;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-202424;Reactome: R-HSA-174113;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5689880;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5678895 "Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of RAS by GAPs";"G2/M Checkpoints";"Degradation of AXIN";"Negative regulation of NOTCH4 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"Neddylation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Vif-mediated degradation of APOBEC3G";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Degradation of GLI1 by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"GLI3 is processed to GLI3R by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of expression of SLITs and ROBOs";"Degradation of DVL";"Interleukin-1 signaling";"Degradation of GLI2 by the proteasome";"Regulation of RUNX3 expression and activity";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"ABC-family proteins mediated transport";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"Downstream TCR signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Ub-specific processing proteases";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis" lcl|NW_020311993.1_prot_XP_012261540.1_21298 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311941.1_prot_XP_012253206.1_11445 2 MetaCyc: PWY-7802;MetaCyc: PWY-7799 "N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)" lcl|NW_020311976.1_prot_XP_020707179.1_17324 16 Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition" lcl|NW_020311971.1_prot_XP_012260919.1_15833 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Relaxin signaling pathway" lcl|NW_020311984.1_prot_XP_020707575.1_19997 5 KEGG: 00760+6.3.4.21;MetaCyc: PWY-5381;Reactome: R-HSA-197264;Reactome: R-HSA-1368108;Reactome: R-HSA-6798695 "Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"Nicotinamide salvaging";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Neutrophil degranulation" lcl|NW_020311992.1_prot_XP_012260883.1_20959 1 Reactome: R-HSA-3295583 "TRP channels" lcl|NW_020311368.1_prot_XP_012264429.1_6218 4 Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311513.1_prot_XP_020711392.1_9905 1 Reactome: R-HSA-1483255 "PI Metabolism" lcl|NW_020311994.1_prot_XP_020710045.1_21843 4 Reactome: R-HSA-1650814;Reactome: R-HSA-2022090;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216 "Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures";"Collagen degradation";"Collagen chain trimerization" lcl|NW_020311978.1_prot_XP_012258102.1_18402 7 Reactome: R-HSA-2894862;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096;Reactome: R-HSA-2644606;MetaCyc: PWY-7511;Reactome: R-HSA-2691232 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants" lcl|NW_020311398.1_prot_XP_012260572.1_7383 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311966.1_prot_XP_020708094.1_14799 1 Reactome: R-HSA-5689877 "Josephin domain DUBs" lcl|NW_020311377.1_prot_XP_012260449.1_6591 2 Reactome: R-HSA-168276;Reactome: R-HSA-1169408 "NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism" lcl|NW_020311513.1_prot_XP_012266206.1_9920 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311926.1_prot_XP_012250899.1_10618 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311934.1_prot_XP_012255130.1_10805 2 KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386 "Pyruvate metabolism";"Methylglyoxal degradation I" lcl|NW_020311932.1_prot_XP_025602301.1_10709 2 Reactome: R-HSA-168276;Reactome: R-HSA-1169408 "NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism" lcl|NW_020311304.1_prot_XP_012260765.1_1883 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311345.1_prot_XP_012254295.1_4912 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" lcl|NW_020311989.1_prot_XP_012263258.1_20747 3 Reactome: R-HSA-379716;Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.4 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311432.1_prot_XP_012268673.1_8388 1 Reactome: R-HSA-373753 "Nephrin family interactions" lcl|NW_020311994.1_prot_XP_012262178.1_21840 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311968.1_prot_XP_012267688.1_15384 3 Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878 "Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport" lcl|NW_020311953.1_prot_XP_020709543.1_12328 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311988.1_prot_XP_020709732.1_20699 3 Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081 "Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling" lcl|NW_020311418.1_prot_XP_012260987.1_8047 3 Reactome: R-HSA-73621;Reactome: R-HSA-196807;Reactome: R-HSA-74259 "Pyrimidine catabolism";"Nicotinate metabolism";"Purine catabolism" lcl|NW_020311298.1_prot_XP_012269918.1_1262 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311977.1_prot_XP_012263900.1_17708 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311993.1_prot_XP_012263310.1_21375 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" lcl|NW_020311298.1_prot_XP_012250520.1_1363 3 Reactome: R-HSA-3108214;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394 "SUMOylation of DNA damage response and repair proteins";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER" lcl|NW_020311333.1_prot_XP_012256073.1_4294 4 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing" lcl|NW_020311292.1_prot_XP_012262802.1_708 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311942.1_prot_XP_012252447.1_11451 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311286.1_prot_XP_020708392.1_221 5 MetaCyc: PWY-6527;MetaCyc: PWY-6317;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;KEGG: 00520+2.7.1.6 "Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"D-galactose detoxification";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311313.1_prot_XP_012261851.1_2849 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311978.1_prot_XP_012258068.1_18138 1 Reactome: R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins" lcl|NW_020311418.1_prot_XP_012261034.1_7988 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311961.1_prot_XP_020710191.1_13423 1 Reactome: R-HSA-425381 "Bicarbonate transporters" lcl|NW_020311441.1_prot_XP_020706510.1_8885 3 KEGG: 00860+1.3.3.4;MetaCyc: PWY-7159;Reactome: R-HSA-189451 "Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis" lcl|NW_020311417.1_prot_XP_025602037.1_7966 1 Reactome: R-HSA-8963901 "Chylomicron remodeling" lcl|NW_020311988.1_prot_XP_012266848.1_20627 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311499.1_prot_XP_012269264.1_9561 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" lcl|NW_020311966.1_prot_XP_012257030.1_14784 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311448.1_prot_XP_012252667.1_9014 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311983.1_prot_XP_012268299.1_19599 2 Reactome: R-HSA-168928;Reactome: R-HSA-70350 "DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Fructose catabolism" lcl|NW_020311948.1_prot_XP_012253530.1_12020 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" lcl|NW_020311992.1_prot_XP_012266458.1_21121 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311355.1_prot_XP_012252918.1_5503 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311436.1_prot_XP_025602102.1_8797 4 Reactome: R-HSA-212300;KEGG: 00270+2.1.1.37;Reactome: R-HSA-5334118;Reactome: R-HSA-4655427 "PRC2 methylates histones and DNA";"Cysteine and methionine metabolism";"DNA methylation";"SUMOylation of DNA methylation proteins" lcl|NW_020311966.1_prot_XP_012257070.1_14806 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311968.1_prot_XP_025602621.1_15503 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" lcl|NW_020311309.1_prot_XP_012259098.1_2392 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" lcl|NW_020311955.1_prot_XP_012265411.1_12465 24 Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-5663220;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-437239;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-5617833;Reactome: R-HSA-3371497;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-1445148;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-190861 "Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases Activate Formins";"Aggrephagy";"Separation of Sister Chromatids";"RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"Recycling pathway of L1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Kinesins";"Resolution of Sister Chromatid Cohesion";"Cilium Assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly" lcl|NW_020311367.1_prot_XP_020709015.1_6084 2 MetaCyc: PWY-6502;Reactome: R-HSA-2393930 "8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins" lcl|NW_020311977.1_prot_XP_020710540.1_17812 14 Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-6798695;Reactome: R-HSA-1474228;Reactome: R-HSA-9017802;Reactome: R-HSA-977225;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-9013700;Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-2644606;Reactome: R-HSA-193692 "NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"Neutrophil degranulation";"Degradation of the extracellular matrix";"Noncanonical activation of NOTCH3";"Amyloid fiber formation";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulated proteolysis of p75NTR" lcl|NW_020311308.1_prot_XP_020710833.1_2184 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311973.1_prot_XP_012258729.1_16333 1 Reactome: R-HSA-912446 "Meiotic recombination" lcl|NW_020311974.1_prot_XP_012260199.1_16935 4 KEGG: 00480+2.5.1.16;KEGG: 00330+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00270+2.5.1.16 "Glutathione metabolism";"Arginine and proline metabolism";"Metabolism of polyamines";"Cysteine and methionine metabolism" lcl|NW_020311973.1_prot_XP_012258767.1_16575 1 Reactome: R-HSA-6806664 "Metabolism of vitamin K" lcl|NW_020311976.1_prot_XP_012253515.1_17291 2 KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7 "Aminobenzoate degradation";"Pyruvate metabolism" lcl|NW_020311317.1_prot_XP_020706643.1_3263 3 Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878 "Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport" lcl|NW_020311973.1_prot_XP_020708856.1_16608 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311961.1_prot_XP_012262515.1_13319 2 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.7 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311973.1_prot_XP_012258708.2_16543 7 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-606279;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Deposition of new CENPA-containing nucleosomes at the centromere";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins" lcl|NW_020311978.1_prot_XP_012258091.1_18130 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311342.1_prot_XP_020707959.1_4726 10 Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-9013695;Reactome: R-HSA-2122947;Reactome: R-HSA-2197563;Reactome: R-HSA-1912408;Reactome: R-HSA-9013508;Reactome: R-HSA-8941856;Reactome: R-HSA-350054;Reactome: R-HSA-210744 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"Pre-NOTCH Transcription and Translation";"NOTCH3 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Notch-HLH transcription pathway";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" lcl|NW_020311994.1_prot_XP_012267559.1_21704 14 MetaCyc: PWY-7254;MetaCyc: PWY-6969;KEGG: 00720+1.3.5.1;KEGG: 00190+1.3.5.1;MetaCyc: PWY-6728;MetaCyc: PWY-5690;MetaCyc: PWY-4302;MetaCyc: PWY-561;Reactome: R-HSA-611105;MetaCyc: PWY-3781;MetaCyc: PWY-7279;KEGG: 00020+1.3.5.1;Reactome: R-HSA-71403;KEGG: 00650+1.3.5.1 "TCA cycle VII (acetate-producers)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"Oxidative phosphorylation";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Respiratory electron transport";"Aerobic respiration I (cytochrome c)";"Aerobic respiration II (cytochrome c) (yeast)";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Butanoate metabolism" lcl|NW_020311956.1_prot_XP_012251384.1_12624 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311966.1_prot_XP_012253694.1_14511 3 Reactome: R-HSA-400206;Reactome: R-HSA-427413;Reactome: R-HSA-8936459 "Regulation of lipid metabolism by PPARalpha";"NoRC negatively regulates rRNA expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" lcl|NW_020311970.1_prot_XP_012267509.1_15785 3 KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16 "Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer" lcl|NW_020311976.1_prot_XP_020707161.1_17220 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311292.1_prot_XP_020706879.1_526 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311992.1_prot_XP_012266430.1_21225 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311977.1_prot_XP_012253911.1_17588 16 Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975956 "Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" lcl|NW_020311976.1_prot_XP_012257112.1_17343 5 MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922 "Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)" lcl|NW_020311971.1_prot_XP_012260960.1_15912 56 Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-5610780;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-5610785;Reactome: R-HSA-174178;Reactome: R-HSA-68827;Reactome: R-HSA-9010553;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-174084;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-1236978;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-195253;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-5632684;Reactome: R-HSA-5689603;Reactome: R-HSA-450408;Reactome: R-HSA-5689880;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-174154;Reactome: R-HSA-5607761;Reactome: R-HSA-68949;Reactome: R-HSA-350562;Reactome: R-HSA-382556;Reactome: R-HSA-8939902;Reactome: R-HSA-8854050;Reactome: R-HSA-349425 "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Degradation of GLI1 by the proteasome";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"GLI3 is processed to GLI3R by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of expression of SLITs and ROBOs";"Degradation of DVL";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"Cross-presentation of soluble exogenous antigens (endosomes)";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of RAS by GAPs";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Degradation of beta-catenin by the destruction complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"Hedgehog 'on' state";"UCH proteinases";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Ub-specific processing proteases";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"APC/C:Cdc20 mediated degradation of Securin";"Dectin-1 mediated noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Regulation of ornithine decarboxylase (ODC)";"ABC-family proteins mediated transport";"Regulation of RUNX2 expression and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Autodegradation of the E3 ubiquitin ligase COP1" lcl|NW_020311375.1_prot_XP_012256574.1_6537 7 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway" lcl|NW_020311979.1_prot_XP_012259442.1_18599 2 Reactome: R-HSA-1268020;Reactome: R-HSA-611105 "Mitochondrial protein import";"Respiratory electron transport" lcl|NW_020311304.1_prot_XP_012261113.1_1915 10 Reactome: R-HSA-2565942;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-2871837;Reactome: R-HSA-5684264;Reactome: R-HSA-5607764;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Regulation of PLK1 Activity at G2/M Transition";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"CLEC7A (Dectin-1) signaling";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311979.1_prot_XP_012259627.1_18501 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311332.1_prot_XP_012268544.1_4132 1 KEGG: 00970+6.1.1.1 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311293.1_prot_XP_012263583.1_855 3 Reactome: R-HSA-6785807;KEGG: 04660+2.7.10.2;Reactome: R-HSA-8854691 "Interleukin-4 and Interleukin-13 signaling";"T cell receptor signaling pathway";"Interleukin-20 family signaling" lcl|NW_020311980.1_prot_XP_020709790.1_18855 1 Reactome: R-HSA-418990 "Adherens junctions interactions" lcl|NW_020311975.1_prot_XP_020707574.1_17026 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311388.1_prot_XP_025601954.1_6990 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311987.1_prot_XP_012269196.1_20357 2 Reactome: R-HSA-425366;Reactome: R-HSA-1483191 "Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC" lcl|NW_020311309.1_prot_XP_012259040.1_2286 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311395.1_prot_XP_012260685.1_7218 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311940.1_prot_XP_012265621.1_11282 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311955.1_prot_XP_020711207.1_12445 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311513.1_prot_XP_020711443.1_9715 1 Reactome: R-HSA-2142789 "Ubiquinol biosynthesis" lcl|NW_020311313.1_prot_XP_012261992.1_2837 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311964.1_prot_XP_025602520.1_13875 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311424.1_prot_XP_020707857.1_8184 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311424.1_prot_XP_012255407.1_8222 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311305.1_prot_XP_020710640.1_1993 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311396.1_prot_XP_012269568.1_7233 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311983.1_prot_XP_012255626.1_19730 2 Reactome: R-HSA-4641265;Reactome: R-HSA-5339700 "Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP" lcl|NW_020311287.1_prot_XP_012268131.1_326 8 Reactome: R-HSA-9609690;Reactome: R-HSA-3214841;Reactome: R-HSA-2559580;Reactome: R-HSA-8953750;Reactome: R-HSA-4551638;Reactome: R-HSA-212300;Reactome: R-HSA-8943724;Reactome: R-HSA-5617472 "HCMV Early Events";"PKMTs methylate histone lysines";"Oxidative Stress Induced Senescence";"Transcriptional Regulation by E2F6";"SUMOylation of chromatin organization proteins";"PRC2 methylates histones and DNA";"Regulation of PTEN gene transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis" lcl|NW_020311362.1_prot_XP_020711000.1_5870 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311981.1_prot_XP_012257404.1_19033 2 Reactome: R-HSA-163282;Reactome: R-HSA-2151201 "Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311925.1_prot_XP_020706885.1_10540 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311959.1_prot_XP_012262408.1_13067 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" lcl|NW_020311966.1_prot_XP_020708410.1_15111 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" lcl|NW_020311432.1_prot_XP_012268710.1_8471 2 Reactome: R-HSA-4549349;Reactome: R-HSA-446193 "Defective ALG2 causes ALG2-CDG (CDG-1i)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" lcl|NW_020311401.1_prot_XP_012262400.1_7411 6 Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695 "Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex" lcl|NW_020311981.1_prot_XP_012257553.1_18996 1 Reactome: R-HSA-390651 "Dopamine receptors" lcl|NW_020311977.1_prot_XP_012253876.1_17586 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" lcl|NW_020311450.1_prot_XP_012260285.1_9048 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311978.1_prot_XP_012257927.1_18419 5 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-112409;Reactome: R-HSA-5675221 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"RAF-independent MAPK1/3 activation";"Negative regulation of MAPK pathway" lcl|NW_020311982.1_prot_XP_012258490.1_19323 2 KEGG: 00450+2.7.9.3;MetaCyc: PWY-6281 "Selenocompound metabolism";"L-selenocysteine biosynthesis II (archaea and eukaryotes)" lcl|NW_020311324.1_prot_XP_012269385.1_3513 10 KEGG: 00564+2.3.1.15;MetaCyc: PWY-7411;MetaCyc: PWY-8055;MetaCyc: PWY-8053;MetaCyc: PWY-5667;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.15;Reactome: R-HSA-1483166;MetaCyc: PWY-8051;MetaCyc: PWY-6453 "Glycerophospholipid metabolism";"Phosphatidate biosynthesis (yeast)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Synthesis of PA";"Anandamide biosynthesis I";"Stigma estolide biosynthesis" lcl|NW_020311294.1_prot_XP_020711016.1_877 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311955.1_prot_XP_020711174.1_12407 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311334.1_prot_XP_012265890.1_4394 3 MetaCyc: PWY-6368;KEGG: 04070+3.1.3.78;MetaCyc: PWY-6367 "3-phosphoinositide degradation";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism" lcl|NW_020311983.1_prot_XP_012255555.1_19775 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311988.1_prot_XP_012261211.1_20734 27 Reactome: R-HSA-1169408;Reactome: R-HSA-9609690;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-4615885;Reactome: R-HSA-4085377;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-180910;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-170822;Reactome: R-HSA-9610379;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-3371453;Reactome: R-HSA-5619107;Reactome: R-HSA-168271;Reactome: R-HSA-180746;Reactome: R-HSA-3232142;Reactome: R-HSA-159227;Reactome: R-HSA-3301854 "ISG15 antiviral mechanism";"HCMV Early Events";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA replication proteins";"SUMOylation of SUMOylation proteins";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"Vpr-mediated nuclear import of PICs";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Late Events";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Regulation of HSF1-mediated heat shock response";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly" lcl|NW_020311417.1_prot_XP_025602026.1_7957 3 Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095 "COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins" lcl|NW_020311433.1_prot_XP_012264019.1_8609 5 MetaCyc: PWY-6749;KEGG: 00250+2.6.1.16;Reactome: R-HSA-446210;MetaCyc: PWY-8013;KEGG: 00520+2.6.1.16 "CMP-legionaminate biosynthesis I";"Alanine, aspartate and glutamate metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311982.1_prot_XP_012258423.1_19191 7 Reactome: R-HSA-1362300;Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-156711 "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"Polo-like kinase mediated events" lcl|NW_020311432.1_prot_XP_012268888.1_8431 1 Reactome: R-HSA-203927 "MicroRNA (miRNA) biogenesis" lcl|NW_020311349.1_prot_XP_012251126.1_5271 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311333.1_prot_XP_012255960.1_4256 5 MetaCyc: PWY-7159;KEGG: 00860+4.1.1.37;MetaCyc: PWY-5531;MetaCyc: PWY-7766;Reactome: R-HSA-189451 "3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)";"Heme b biosynthesis IV (Gram-positive bacteria)";"Heme biosynthesis" lcl|NW_020311507.1_prot_XP_020709183.1_9626 11 Reactome: R-HSA-163359;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-418555;Reactome: R-HSA-164378;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;Reactome: R-HSA-418597;Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-163615 "Glucagon signaling in metabolic regulation";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"G alpha (s) signalling events";"PKA activation in glucagon signalling";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"Purine metabolism";"PKA activation" lcl|NW_020311973.1_prot_XP_012258747.1_16384 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311943.1_prot_XP_012255142.1_11679 3 Reactome: R-HSA-111471;Reactome: R-HSA-9645722;Reactome: R-HSA-140837 "Apoptotic factor-mediated response";"Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function";"Intrinsic Pathway of Fibrin Clot Formation" lcl|NW_020311296.1_prot_XP_020711069.1_1005 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311948.1_prot_XP_012253571.1_11995 2 Reactome: R-HSA-6783310;Reactome: R-HSA-5693568 "Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311990.1_prot_XP_012266743.1_20828 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311292.1_prot_XP_020710263.1_687 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-112308;Reactome: R-HSA-5576893 "NCAM1 interactions";"Phase 0 - rapid depolarisation";"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase" lcl|NW_020311968.1_prot_XP_012253055.1_15452 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311361.1_prot_XP_012261591.1_5837 7 Reactome: R-HSA-1483148;KEGG: 00564+3.1.4.4;Reactome: R-HSA-1483166;MetaCyc: PWY-3561;KEGG: 00565+3.1.4.4;MetaCyc: PWY-7039;Reactome: R-HSA-2029485 "Synthesis of PG";"Glycerophospholipid metabolism";"Synthesis of PA";"Choline biosynthesis III";"Ether lipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Role of phospholipids in phagocytosis" lcl|NW_020311292.1_prot_XP_012252510.1_580 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311988.1_prot_XP_020710800.1_20481 32 Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-75955;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-674695;Reactome: R-HSA-72165;Reactome: R-HSA-167172;Reactome: R-HSA-8851708;Reactome: R-HSA-75953;Reactome: R-HSA-77075;Reactome: R-HSA-167161;Reactome: R-HSA-167242;Reactome: R-HSA-6807505;Reactome: R-HSA-6796648;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-113418;Reactome: R-HSA-72163;Reactome: R-HSA-76042;Reactome: R-HSA-167158;Reactome: R-HSA-112382 "RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"RNA Polymerase II Transcription Elongation";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Pre-transcription Events";"mRNA Splicing - Minor Pathway";"Transcription of the HIV genome";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE";"HIV Transcription Initiation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA polymerase II transcribes snRNA genes";"TP53 Regulates Transcription of DNA Repair Genes";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of the Early Elongation Complex";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of the HIV-1 Early Elongation Complex";"Formation of RNA Pol II elongation complex" lcl|NW_020311973.1_prot_XP_012258562.1_16430 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"RHO GTPases Activate Formins" lcl|NW_020311955.1_prot_XP_012265341.1_12499 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" lcl|NW_020311940.1_prot_XP_020711228.1_11180 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311397.1_prot_XP_012253757.1_7354 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" lcl|NW_020311977.1_prot_XP_020710733.1_17778 2 Reactome: R-HSA-8949613;Reactome: R-HSA-1268020 "Cristae formation";"Mitochondrial protein import" lcl|NW_020311926.1_prot_XP_012250830.1_10599 5 Reactome: R-HSA-5689603;Reactome: R-HSA-8856825;Reactome: R-HSA-917937;Reactome: R-HSA-8951664;Reactome: R-HSA-2173789 "UCH proteinases";"Cargo recognition for clathrin-mediated endocytosis";"Iron uptake and transport";"Neddylation";"TGF-beta receptor signaling activates SMADs" lcl|NW_020311498.1_prot_XP_012255047.1_9522 1 Reactome: R-HSA-6783984 "Glycine degradation" lcl|NW_020311940.1_prot_XP_025602343.1_11187 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311340.1_prot_XP_012269637.1_4674 2 Reactome: R-HSA-6798695;Reactome: R-HSA-8964038 "Neutrophil degranulation";"LDL clearance" lcl|NW_020311934.1_prot_XP_020707731.1_10880 1 Reactome: R-HSA-1474151 "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" lcl|NW_020311397.1_prot_XP_020707303.1_7344 3 Reactome: R-HSA-75109;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Triglyceride biosynthesis";"Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311968.1_prot_XP_025602617.1_15448 2 Reactome: R-HSA-5673001;Reactome: R-HSA-8853659 "RAF/MAP kinase cascade";"RET signaling" lcl|NW_020311965.1_prot_XP_012259671.1_14311 7 Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-5628897 "Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes" lcl|NW_020311985.1_prot_XP_020711086.1_20200 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311459.1_prot_XP_012260500.1_9171 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311959.1_prot_XP_012262376.1_13112 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" lcl|NW_020311986.1_prot_XP_012258842.1_20333 5 Reactome: R-HSA-77595;Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" lcl|NW_020311331.1_prot_XP_012264260.1_4101 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311940.1_prot_XP_020711222.1_11196 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311309.1_prot_XP_020709066.1_2375 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311338.1_prot_XP_020710349.1_4551 2 Reactome: R-HSA-5689880;MetaCyc: PWY-7511 "Ub-specific processing proteases";"Protein ubiquitination" lcl|NW_020311436.1_prot_XP_012258338.1_8756 6 Reactome: R-HSA-5675221;Reactome: R-HSA-5693565;KEGG: 04658+3.1.3.16;Reactome: R-HSA-8939211;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Negative regulation of MAPK pathway";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Th1 and Th2 cell differentiation";"ESR-mediated signaling";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311977.1_prot_XP_012264103.1_17762 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311292.1_prot_XP_020710278.1_705 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311424.1_prot_XP_012255404.1_8224 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311983.1_prot_XP_020712112.1_19634 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" lcl|NW_020311984.1_prot_XP_020711934.1_20133 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311965.1_prot_XP_012259501.1_14364 3 Reactome: R-HSA-6782315;MetaCyc: PWY-6700;MetaCyc: PWY-8106 "tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis I (de novo)";"Queuosine biosynthesis III (queuosine salvage)" lcl|NW_020311401.1_prot_XP_012254958.1_7614 3 KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029;MetaCyc: PWY-7221 "Purine metabolism";"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis" lcl|NW_020311326.1_prot_XP_012261519.1_3717 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" lcl|NW_020311432.1_prot_XP_012268885.1_8494 6 KEGG: 04070+2.7.11.13;Reactome: R-HSA-416993;Reactome: R-HSA-76005;Reactome: R-HSA-114516;Reactome: R-HSA-418597;Reactome: R-HSA-5099900 "Phosphatidylinositol signaling system";"Trafficking of GluR2-containing AMPA receptors";"Response to elevated platelet cytosolic Ca2+";"Disinhibition of SNARE formation";"G alpha (z) signalling events";"WNT5A-dependent internalization of FZD4" lcl|NW_020311976.1_prot_XP_012253503.1_17293 14 Reactome: R-HSA-68877;Reactome: R-HSA-2173788;Reactome: R-HSA-9634638;Reactome: R-HSA-450520;Reactome: R-HSA-9648025;Reactome: R-HSA-165054;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-3769402;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-5687128;Reactome: R-HSA-69273;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"Downregulation of TGF-beta receptor signaling";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"HuR (ELAVL1) binds and stabilizes mRNA";"EML4 and NUDC in mitotic spindle formation";"Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Deactivation of the beta-catenin transactivating complex";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"MAPK6/MAPK4 signaling";"Cyclin A/B1/B2 associated events during G2/M transition";"Separation of Sister Chromatids" lcl|NW_020311995.1_prot_XP_012257041.1_21885 7 MetaCyc: PWY-2301;KEGG: 00562+3.1.3.25;Reactome: R-HSA-1855183;MetaCyc: PWY-6363;MetaCyc: PWY-4702;KEGG: 04070+3.1.3.25;KEGG: 00521+3.1.3.25 "Myo-inositol biosynthesis";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Phytate degradation I";"Phosphatidylinositol signaling system";"Streptomycin biosynthesis" lcl|NW_020311397.1_prot_XP_012253765.1_7327 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311298.1_prot_XP_020706237.1_1135 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311513.1_prot_XP_012266064.1_9824 11 KEGG: 00020+1.1.1.42;KEGG: 00720+1.1.1.42;Reactome: R-HSA-71403;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-7254;KEGG: 00480+1.1.1.42;MetaCyc: PWY-7124;MetaCyc: PWY-6728;MetaCyc: PWY-7268;MetaCyc: PWY-6549 "Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Citric acid cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle VII (acetate-producers)";"Glutathione metabolism";"Ethylene biosynthesis V (engineered)";"Methylaspartate cycle";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"L-glutamine biosynthesis III" lcl|NW_020311972.1_prot_XP_012267925.1_16271 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" lcl|NW_020311957.1_prot_XP_020710484.1_12838 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" lcl|NW_020311940.1_prot_XP_012265675.1_11247 14 MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-5972 "Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)" lcl|NW_020311961.1_prot_XP_012262674.1_13431 1 Reactome: R-HSA-9033241 "Peroxisomal protein import" lcl|NW_020311937.1_prot_XP_012252637.1_11036 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" lcl|NW_020311365.1_prot_XP_020712486.1_6001 4 Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription" lcl|NW_020311991.1_prot_XP_012269734.1_20919 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311303.1_prot_XP_012264563.1_1718 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311934.1_prot_XP_020707745.1_10819 2 KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20 "Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis" lcl|NW_020311978.1_prot_XP_020708601.1_18380 6 Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" lcl|NW_020311364.1_prot_XP_012258865.1_5932 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311992.1_prot_XP_012266466.1_21194 13 Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72764 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination" lcl|NW_020311946.1_prot_XP_012268869.1_11875 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311356.1_prot_XP_012267061.1_5559 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" lcl|NW_020311977.1_prot_XP_012263918.1_17858 6 MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656 "Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis" lcl|NW_020311306.1_prot_XP_012264232.1_2083 9 MetaCyc: PWY-7852;MetaCyc: PWY-6983;MetaCyc: PWY-6147;MetaCyc: PWY-6703;Reactome: R-HSA-1474151;MetaCyc: PWY-7442;MetaCyc: PWY-5664;KEGG: 00790+3.5.4.16;MetaCyc: PWY-5663 "6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Threo-tetrahydrobiopterin biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Preq0 biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Drosopterin and aurodrosopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis II";"Folate biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I" lcl|NW_020311345.1_prot_XP_012254296.1_4908 26 Reactome: R-HSA-5663220;Reactome: R-HSA-8955332;Reactome: R-HSA-9609690;Reactome: R-HSA-380320;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-437239;Reactome: R-HSA-3371497;Reactome: R-HSA-5617833;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-389960;Reactome: R-HSA-389977;Reactome: R-HSA-1445148;Reactome: R-HSA-190861;Reactome: R-HSA-9609736;Reactome: R-HSA-190840 "RHO GTPases Activate Formins";"Carboxyterminal post-translational modifications of tubulin";"HCMV Early Events";"Recruitment of NuMA to mitotic centrosomes";"Separation of Sister Chromatids";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Recycling pathway of L1";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Cilium Assembly";"Kinesins";"Resolution of Sister Chromatid Cohesion";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Formation of tubulin folding intermediates by CCT/TriC";"Post-chaperonin tubulin folding pathway";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Gap junction assembly";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" lcl|NW_020311338.1_prot_XP_012263071.1_4536 4 Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664 "Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation" lcl|NW_020311364.1_prot_XP_020708944.1_5898 6 KEGG: 00520+1.1.1.22;MetaCyc: PWY-7820;Reactome: R-HSA-173599;KEGG: 00040+1.1.1.22;KEGG: 00053+1.1.1.22;MetaCyc: PWY-7346 "Amino sugar and nucleotide sugar metabolism";"Teichuronic acid biosynthesis (B. subtilis 168)";"Formation of the active cofactor, UDP-glucuronate";"Pentose and glucuronate interconversions";"Ascorbate and aldarate metabolism";"UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)" lcl|NW_020311980.1_prot_XP_012261359.2_18872 2 Reactome: R-HSA-8949664;Reactome: R-HSA-8949215 "Processing of SMDT1";"Mitochondrial calcium ion transport" lcl|NW_020311333.1_prot_XP_012256096.1_4243 3 Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-75955 "RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation" lcl|NW_020311988.1_prot_XP_012269469.1_20485 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" lcl|NW_020311396.1_prot_XP_025601985.1_7274 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311397.1_prot_XP_012258189.1_7292 3 Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359 "Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels" lcl|NW_020311360.1_prot_XP_025601871.1_5739 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311294.1_prot_XP_020711026.1_867 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311975.1_prot_XP_012251047.1_17091 2 Reactome: R-HSA-110320;Reactome: R-HSA-5689880 "Translesion Synthesis by POLH";"Ub-specific processing proteases" lcl|NW_020311304.1_prot_XP_012261155.1_1759 5 Reactome: R-HSA-8875360;Reactome: R-HSA-6807004;Reactome: R-HSA-8856828;Reactome: R-HSA-182971;Reactome: R-HSA-8856825 "InlB-mediated entry of Listeria monocytogenes into host cell";"Negative regulation of MET activity";"Clathrin-mediated endocytosis";"EGFR downregulation";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311392.1_prot_XP_012250928.1_7090 13 Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72689 "SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits" lcl|NW_020311955.1_prot_XP_012265418.1_12545 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311940.1_prot_XP_025602345.1_11195 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" lcl|NW_020311286.1_prot_XP_012257185.1_151 5 Reactome: R-HSA-430039;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450385 "mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" lcl|NW_020311983.1_prot_XP_020711767.1_19499 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" lcl|NW_020311312.1_prot_XP_012266769.1_2772 1 Reactome: R-HSA-381038 "XBP1(S) activates chaperone genes" lcl|NW_020311322.1_prot_XP_012267981.1_3443 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" lcl|NW_020311957.1_prot_XP_012261074.1_12681 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311977.1_prot_XP_012263921.1_17861 6 MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463 "Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis" lcl|NW_020311974.1_prot_XP_012260000.1_16643 6 Reactome: R-HSA-212676;Reactome: R-HSA-264642;Reactome: R-HSA-388844;Reactome: R-HSA-181429;Reactome: R-HSA-181430;Reactome: R-HSA-210500 "Dopamine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Serotonin Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle" lcl|NW_020311993.1_prot_XP_012262687.1_21341 2 Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198 "Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis" lcl|NW_020311373.1_prot_XP_012266675.1_6432 13 Reactome: R-HSA-3928662;Reactome: R-HSA-4420097;Reactome: R-HSA-416572;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5627117;Reactome: R-HSA-3928663;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-416482 "EPHB-mediated forward signaling";"VEGFA-VEGFR2 Pathway";"Sema4D induced cell migration and growth-cone collapse";"Human cytomegalovirus infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"RHO GTPases Activate ROCKs";"EPHA-mediated growth cone collapse";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"G alpha (12/13) signalling events" lcl|NW_020311320.1_prot_XP_020712040.1_3369 5 Reactome: R-HSA-73863;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-73772 "RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape" lcl|NW_020311973.1_prot_XP_020708843.1_16383 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" lcl|NW_020311985.1_prot_XP_012253977.1_20300 3 Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916 "Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium" lcl|NW_020311977.1_prot_XP_020710731.1_17870 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311978.1_prot_XP_020708588.1_18356 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311961.1_prot_XP_012262537.1_13542 2 Reactome: R-HSA-3238698;Reactome: R-HSA-373080 "WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)" lcl|NW_020311966.1_prot_XP_012251723.1_14580 19 MetaCyc: PWY-6969;MetaCyc: PWY-5538;KEGG: 00720+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-6728;Reactome: R-HSA-6798695;MetaCyc: PWY-5392;KEGG: 00020+2.3.3.8;MetaCyc: PWY-5537;MetaCyc: PWY-5913;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5172;Reactome: R-HSA-75105;MetaCyc: PWY-7384;Reactome: R-HSA-163765;Reactome: R-HSA-71403 "TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Carbon fixation pathways in prokaryotes";"C5-Branched dibasic acid metabolism";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Neutrophil degranulation";"Reductive TCA cycle II";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate V";"Partial TCA cycle (obligate autotrophs)";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Acetyl-coa biosynthesis III (from citrate)";"Fatty acyl-CoA biosynthesis";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"ChREBP activates metabolic gene expression";"Citric acid cycle (TCA cycle)" lcl|NW_020311306.1_prot_XP_012264230.1_2085 9 MetaCyc: PWY-5664;KEGG: 00790+3.5.4.16;MetaCyc: PWY-7442;Reactome: R-HSA-1474151;MetaCyc: PWY-6983;MetaCyc: PWY-7852;MetaCyc: PWY-6703;MetaCyc: PWY-6147;MetaCyc: PWY-5663 "Erythro-tetrahydrobiopterin biosynthesis II";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Threo-tetrahydrobiopterin biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Preq0 biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Erythro-tetrahydrobiopterin biosynthesis I" lcl|NW_020311982.1_prot_XP_012258421.1_19189 7 Reactome: R-HSA-156711;Reactome: R-HSA-69656;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69202;Reactome: R-HSA-1362300;Reactome: R-HSA-1538133 "Polo-like kinase mediated events";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G0 and Early G1" lcl|NW_020311926.1_prot_XP_012250867.1_10613 6 Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-6798695;Reactome: R-HSA-917977 "ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Neutrophil degranulation";"Transferrin endocytosis and recycling" lcl|NW_020311365.1_prot_XP_020712504.1_6035 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311988.1_prot_XP_020709735.1_20700 3 Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081 "Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling" lcl|NW_020311458.1_prot_XP_012264675.1_9158 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" lcl|NW_020311962.1_prot_XP_012252011.1_13745 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" lcl|NW_020311957.1_prot_XP_012263326.1_12819 2 Reactome: R-HSA-8849175;KEGG: 00260+2.3.1.29 "Threonine catabolism";"Glycine, serine and threonine metabolism" lcl|NW_020311940.1_prot_XP_025602340.1_11192 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" lcl|NW_020311978.1_prot_XP_012257965.1_18242 4 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-6807505;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"RNA polymerase II transcribes snRNA genes";"Th1 and Th2 cell differentiation" lcl|NW_020311313.1_prot_XP_012261833.1_3030 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311989.1_prot_XP_020710417.1_20771 12 MetaCyc: PWY-5872;Reactome: R-HSA-1268020;MetaCyc: PWY-5871;Reactome: R-HSA-2142789;MetaCyc: PWY-5856;MetaCyc: PWY-6978;MetaCyc: PWY-5870;KEGG: 00130+2.5.1.39;MetaCyc: PWY-6708;MetaCyc: PWY-5855;MetaCyc: PWY-5857;MetaCyc: PWY-5873 "Ubiquinol-10 biosynthesis (eukaryotic)";"Mitochondrial protein import";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)" lcl|NW_020311977.1_prot_XP_012263937.1_17872 1 Reactome: R-HSA-71384 "Ethanol oxidation" lcl|NW_020311310.1_prot_XP_012255774.1_2425 13 Reactome: R-HSA-416993;Reactome: R-HSA-5140745;Reactome: R-HSA-182218;Reactome: R-HSA-8856828;Reactome: R-HSA-177504;Reactome: R-HSA-8866427;Reactome: R-HSA-3928665;Reactome: R-HSA-437239;Reactome: R-HSA-2132295;Reactome: R-HSA-8856825;Reactome: R-HSA-8964038;Reactome: R-HSA-167590;Reactome: R-HSA-5099900 "Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Nef Mediated CD8 Down-regulation";"Clathrin-mediated endocytosis";"Retrograde neurotrophin signalling";"VLDLR internalisation and degradation";"EPH-ephrin mediated repulsion of cells";"Recycling pathway of L1";"MHC class II antigen presentation";"Cargo recognition for clathrin-mediated endocytosis";"LDL clearance";"Nef Mediated CD4 Down-regulation";"WNT5A-dependent internalization of FZD4" lcl|NW_020311425.1_prot_XP_012265063.1_8244 3 Reactome: R-HSA-6807004;Reactome: R-HSA-6798695;Reactome: R-HSA-202427 "Negative regulation of MET activity";"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains" lcl|NW_020311932.1_prot_XP_012257417.1_10713 6 Reactome: R-HSA-1855204;Reactome: R-HSA-1855183;MetaCyc: PWY-6368;KEGG: 04070+3.1.3.36;Reactome: R-HSA-194840;KEGG: 00562+3.1.3.36 "Synthesis of IP3 and IP4 in the cytosol";"Synthesis of IP2, IP, and Ins in the cytosol";"3-phosphoinositide degradation";"Phosphatidylinositol signaling system";"Rho GTPase cycle";"Inositol phosphate metabolism" lcl|NW_020311289.1_prot_XP_012256163.1_397 4 KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943 "Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates" lcl|NW_020311937.1_prot_XP_012252648.1_11027 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311317.1_prot_XP_012254109.1_3212 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311349.1_prot_XP_012262371.1_5189 13 Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72689 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits" lcl|NW_020311975.1_prot_XP_012252666.1_17103 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311977.1_prot_XP_012253867.1_17559 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311976.1_prot_XP_020707246.1_17240 2 Reactome: R-HSA-8866907;Reactome: R-HSA-8866904 "Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors" lcl|NW_020311977.1_prot_XP_012263718.1_17668 5 Reactome: R-HSA-159231;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856 "Transport of Mature mRNA Derived from an Intronless Transcript";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination" lcl|NW_020311559.1_prot_XP_025602220.1_10039 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" lcl|NW_020311401.1_prot_XP_012255062.1_7637 16 Reactome: R-HSA-9029569;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-8853884;Reactome: R-HSA-2559585;Reactome: R-HSA-8936459;Reactome: R-HSA-8934593;Reactome: R-HSA-8943723 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"Transcriptional Regulation by VENTX";"Oncogene Induced Senescence";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX1 Expression and Activity";"Regulation of PTEN mRNA translation" lcl|NW_020311966.1_prot_XP_012256383.1_14961 7 Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"RHO GTPases Activate Formins" lcl|NW_020311943.1_prot_XP_020707668.1_11680 1 Reactome: R-HSA-6803204 "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" lcl|NW_020311967.1_prot_XP_012256018.2_15220 5 Reactome: R-HSA-5675221;Reactome: R-HSA-112409;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Negative regulation of MAPK pathway";"RAF-independent MAPK1/3 activation";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" lcl|NW_020311964.1_prot_XP_025602511.1_13867 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311475.1_prot_XP_012253316.1_9394 16 Reactome: R-HSA-416476;Reactome: R-HSA-512988;Reactome: R-HSA-912631;Reactome: R-HSA-8853659;Reactome: R-HSA-912526;Reactome: R-HSA-114604;Reactome: R-HSA-194840;Reactome: R-HSA-9009391;Reactome: R-HSA-388841;Reactome: R-HSA-1266695;Reactome: R-HSA-1660499;Reactome: R-HSA-1433557;Reactome: R-HSA-1257604;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558;Reactome: R-HSA-389357 "G alpha (q) signalling events";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of signaling by CBL";"RET signaling";"Interleukin receptor SHC signaling";"GPVI-mediated activation cascade";"Rho GTPase cycle";"Extra-nuclear estrogen signaling";"Costimulation by the CD28 family";"Interleukin-7 signaling";"Synthesis of PIPs at the plasma membrane";"Signaling by SCF-KIT";"PIP3 activates AKT signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"CD28 dependent PI3K/Akt signaling" lcl|NW_020311992.1_prot_XP_012266515.1_21167 4 Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)" lcl|NW_020311286.1_prot_XP_012256337.1_172 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" lcl|NW_020311950.1_prot_XP_020710808.1_12101 5 KEGG: 00720+4.2.1.3;Reactome: R-HSA-917937;KEGG: 00020+4.2.1.3;KEGG: 00290+4.2.1.33;KEGG: 00630+4.2.1.3 "Carbon fixation pathways in prokaryotes";"Iron uptake and transport";"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine biosynthesis";"Glyoxylate and dicarboxylate metabolism" lcl|NW_020311305.1_prot_XP_012263696.1_2006 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311959.1_prot_XP_012262304.1_13108 3 Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" lcl|NW_020311292.1_prot_XP_012252418.1_632 1 Reactome: R-HSA-426486 "Small interfering RNA (siRNA) biogenesis" lcl|NW_020311401.1_prot_XP_012255292.1_7450 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" lcl|NW_020311401.1_prot_XP_012255358.1_7652 4 Reactome: R-HSA-201681;Reactome: R-HSA-5689880;Reactome: R-HSA-418594;Reactome: R-HSA-4641257 "TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"G alpha (i) signalling events";"Degradation of AXIN" lcl|NW_020311978.1_prot_XP_012257729.1_18154 1 Reactome: R-HSA-70350 "Fructose catabolism" lcl|NW_020311479.1_prot_XP_025602160.1_9457 14 MetaCyc: PWY-1042;MetaCyc: PWY-6901;MetaCyc: PWY-2221;MetaCyc: PWY-8004;MetaCyc: PWY-6142;KEGG: 00680+4.2.1.11;MetaCyc: PWY-7003;MetaCyc: PWY-1622;KEGG: 00010+4.2.1.11;MetaCyc: PWY-6886;MetaCyc: PWY-5484;MetaCyc: PWY-7124;MetaCyc: PWY-5723;MetaCyc: PWY-7218 "Glycolysis IV (plant cytosol)";"Superpathway of glucose and xylose degradation";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Entner-Doudoroff pathway I";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Methane metabolism";"Glycerol degradation to butanol";"Formaldehyde assimilation I (serine pathway)";"Glycolysis / Gluconeogenesis";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Ethylene biosynthesis V (engineered)";"Rubisco shunt";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)" lcl|NW_020311353.1_prot_XP_025601836.1_5393 13 Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72706 "Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit" lcl|NW_020311982.1_prot_XP_012258367.1_19207 2 Reactome: R-HSA-8854518;Reactome: R-HSA-6804756 "AURKA Activation by TPX2";"Regulation of TP53 Activity through Phosphorylation" lcl|NW_020311977.1_prot_XP_012253873.1_17560 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311983.1_prot_XP_012267257.1_19413 5 Reactome: R-HSA-73772;Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-73863;Reactome: R-HSA-73762 "RNA Polymerase I Promoter Escape";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation" lcl|NW_020311971.1_prot_XP_012263500.2_16142 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311940.1_prot_XP_012265573.1_11211 7 KEGG: 00500+2.4.1.25;MetaCyc: PWY-6737;MetaCyc: PWY-5941;Reactome: R-HSA-70221;MetaCyc: PWY-6724;Reactome: R-HSA-6798695;MetaCyc: PWY-7238 "Starch and sucrose metabolism";"Starch degradation V";"Glycogen degradation II";"Glycogen breakdown (glycogenolysis)";"Starch degradation II";"Neutrophil degranulation";"Sucrose biosynthesis II" lcl|NW_020311925.1_prot_XP_020706887.1_10541 1 Reactome: R-HSA-5620924 "Intraflagellar transport" lcl|NW_020311472.1_prot_XP_012269223.1_9323 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311988.1_prot_XP_012260837.1_20562 5 MetaCyc: PWY-5084;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2 "2-oxoglutarate decarboxylation to succinyl-CoA";"Citrate cycle (TCA cycle)";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism" lcl|NW_020311333.1_prot_XP_012256136.1_4219 2 Reactome: R-HSA-382556;Reactome: R-HSA-5678895 "ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis" lcl|NW_020311966.1_prot_XP_012256997.1_15091 8 Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-8943724;Reactome: R-HSA-3371571;Reactome: R-HSA-1632852;Reactome: R-HSA-9639288 "TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Regulation of PTEN gene transcription";"HSF1-dependent transactivation";"Macroautophagy";"Amino acids regulate mTORC1" lcl|NW_020311297.1_prot_XP_020707427.1_1085 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311317.1_prot_XP_012253020.1_3261 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" lcl|NW_020311349.1_prot_XP_012251225.1_5290 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311961.1_prot_XP_012262549.1_13514 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311441.1_prot_XP_012251258.1_8858 3 KEGG: 00620+4.4.1.5;Reactome: R-HSA-70268;MetaCyc: PWY-5386 "Pyruvate metabolism";"Pyruvate metabolism";"Methylglyoxal degradation I" lcl|NW_020311380.1_prot_XP_012266639.1_6664 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" lcl|NW_020311338.1_prot_XP_020710335.1_4535 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" lcl|NW_020311988.1_prot_XP_020712295.1_20582 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311979.1_prot_XP_012259517.1_18527 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311315.1_prot_XP_020711117.1_3118 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311959.1_prot_XP_020710133.1_13103 1 Reactome: R-HSA-196108 "Pregnenolone biosynthesis" lcl|NW_020311966.1_prot_XP_012256568.1_14830 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311943.1_prot_XP_012255334.1_11692 12 KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7409 "Linoleic acid metabolism";"Plasmalogen degradation";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)" lcl|NW_020311966.1_prot_XP_012251718.1_14576 19 MetaCyc: PWY-5172;Reactome: R-HSA-163765;Reactome: R-HSA-71403;Reactome: R-HSA-75105;MetaCyc: PWY-7384;KEGG: 00020+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913;KEGG: 00720+2.3.3.8;KEGG: 00020+2.3.3.8;MetaCyc: PWY-5537;MetaCyc: PWY-6969;MetaCyc: PWY-5538;Reactome: R-HSA-6798695;MetaCyc: PWY-5392;MetaCyc: PWY-5690;MetaCyc: PWY-6728;KEGG: 00660+6.2.1.5;KEGG: 00720+6.2.1.5 "Acetyl-coa biosynthesis III (from citrate)";"ChREBP activates metabolic gene expression";"Citric acid cycle (TCA cycle)";"Fatty acyl-CoA biosynthesis";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citrate cycle (TCA cycle)";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate V";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Neutrophil degranulation";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"C5-Branched dibasic acid metabolism";"Carbon fixation pathways in prokaryotes" lcl|NW_020311304.1_prot_XP_020709291.1_1874 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" lcl|NW_020311959.1_prot_XP_020709508.1_13033 2 Reactome: R-HSA-6807878;Reactome: R-HSA-445095 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins" lcl|NW_020311933.1_prot_XP_012252877.1_10762 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" lcl|NW_020311976.1_prot_XP_012257253.1_17418 1 Reactome: R-HSA-5693565 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" lcl|NW_020311981.1_prot_XP_012257352.1_19065 2 Reactome: R-HSA-6785470;Reactome: R-HSA-6784531 "tRNA processing in the mitochondrion";"tRNA processing in the nucleus" lcl|NW_020311995.1_prot_XP_012257258.1_22064 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311380.1_prot_XP_012261409.1_6674 9 Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616 "Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange" lcl|NW_020311966.1_prot_XP_012256609.1_15113 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" lcl|NW_020311353.1_prot_XP_025601839.1_5386 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" lcl|NW_020311432.1_prot_XP_025602078.1_8313 11 MetaCyc: PWY-6352;KEGG: 04070+2.7.1.137;Reactome: R-HSA-1632852;Reactome: R-HSA-168138;Reactome: R-HSA-5668599;KEGG: 00562+2.7.1.137;Reactome: R-HSA-1660514;Reactome: R-HSA-1660517;Reactome: R-HSA-109704;Reactome: R-HSA-1660516;Reactome: R-HSA-1660499 "3-phosphoinositide biosynthesis";"Phosphatidylinositol signaling system";"Macroautophagy";"Toll Like Receptor 9 (TLR9) Cascade";"RHO GTPases Activate NADPH Oxidases";"Inositol phosphate metabolism";"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the late endosome membrane";"PI3K Cascade";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the plasma membrane" lcl|NW_020311978.1_prot_XP_012257712.1_18247 3 MetaCyc: PWY-6857;KEGG: 00561+3.1.1.3;Reactome: R-HSA-192456 "Retinol biosynthesis";"Glycerolipid metabolism";"Digestion of dietary lipid" lcl|NW_020311353.1_prot_XP_020708051.1_5430 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311984.1_prot_XP_012254660.1_19900 3 Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-75955 "RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation" lcl|NW_020311354.1_prot_XP_020709560.1_5490 13 MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11;Reactome: R-HSA-2424491;Reactome: R-HSA-2871796;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11;Reactome: R-HSA-9027277;Reactome: R-HSA-2029485;MetaCyc: PWY-6367;Reactome: R-HSA-202433;MetaCyc: PWY-6351;Reactome: R-HSA-2871809;MetaCyc: PWY-8052 "Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism";"DAP12 signaling";"FCERI mediated MAPK activation";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"Erythropoietin activates Phospholipase C gamma (PLCG)";"Role of phospholipids in phagocytosis";"D-myo-inositol-5-phosphate metabolism";"Generation of second messenger molecules";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"FCERI mediated Ca+2 mobilization";"2-arachidonoylglycerol biosynthesis" lcl|NW_020311970.1_prot_XP_012260239.1_15607 33 Reactome: R-HSA-2467813;Reactome: R-HSA-4615885;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-159236;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-9648025;Reactome: R-HSA-180910;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-68877;Reactome: R-HSA-168276;Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-3371453;Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-170822;Reactome: R-HSA-168325;Reactome: R-HSA-159227;Reactome: R-HSA-180746;Reactome: R-HSA-3232142 "Separation of Sister Chromatids";"SUMOylation of DNA replication proteins";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"RHO GTPases Activate Formins";"HCMV Early Events";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"EML4 and NUDC in mitotic spindle formation";"Vpr-mediated nuclear import of PICs";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"Mitotic Prometaphase";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Regulation of HSF1-mediated heat shock response";"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Viral Messenger RNA Synthesis";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins" lcl|NW_020311355.1_prot_XP_020706981.1_5501 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311286.1_prot_XP_012257035.1_133 9 MetaCyc: PWY-6146;Reactome: R-HSA-196780;KEGG: 00620+6.4.1.1;Reactome: R-HSA-3371599;MetaCyc: PWY-6142;KEGG: 00020+6.4.1.1;MetaCyc: PWY-8086;KEGG: 00720+6.4.1.1;Reactome: R-HSA-70263 "Methanobacterium thermoautotrophicum biosynthetic metabolism";"Biotin transport and metabolism";"Pyruvate metabolism";"Defective HLCS causes multiple carboxylase deficiency";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Citrate cycle (TCA cycle)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis" lcl|NW_020311397.1_prot_XP_012253732.1_7348 3 KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261;Reactome: R-HSA-75109 "Glycerolipid metabolism";"Glycerol degradation I";"Triglyceride biosynthesis" lcl|NW_020311993.1_prot_XP_012262627.1_21371 14 MetaCyc: PWY-6969;MetaCyc: PWY-7254;KEGG: 00720+1.3.5.1;MetaCyc: PWY-5690;MetaCyc: PWY-6728;KEGG: 00190+1.3.5.1;MetaCyc: PWY-4302;MetaCyc: PWY-561;Reactome: R-HSA-611105;MetaCyc: PWY-3781;MetaCyc: PWY-7279;KEGG: 00020+1.3.5.1;Reactome: R-HSA-71403;KEGG: 00650+1.3.5.1 "TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle VII (acetate-producers)";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Oxidative phosphorylation";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Respiratory electron transport";"Aerobic respiration I (cytochrome c)";"Aerobic respiration II (cytochrome c) (yeast)";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Butanoate metabolism" lcl|NW_020311958.1_prot_XP_012255565.1_12927 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311971.1_prot_XP_025602652.1_16128 6 MetaCyc: PWY-7765;MetaCyc: PWY-5651;KEGG: 00380+1.14.13.9;Reactome: R-HSA-71240;MetaCyc: PWY-7717;MetaCyc: PWY-6309 "3-hydroxy-4-methyl-anthranilate biosynthesis II";"L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde";"Tryptophan metabolism";"Tryptophan catabolism";"3-hydroxy-4-methyl-anthranilate biosynthesis I";"L-tryptophan degradation XI (mammalian, via kynurenine)" lcl|NW_020311978.1_prot_XP_012257917.1_18413 1 Reactome: R-HSA-77108 "Utilization of Ketone Bodies" lcl|NW_020311978.1_prot_XP_012257913.1_18418 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311964.1_prot_XP_020709949.1_14025 6 Reactome: R-HSA-912446;Reactome: R-HSA-5358606;Reactome: R-HSA-5632987;Reactome: R-HSA-6796648;Reactome: R-HSA-5358565;Reactome: R-HSA-5545483 "Meiotic recombination";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With PMS2";"TP53 Regulates Transcription of DNA Repair Genes";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MLH1" lcl|NW_020311978.1_prot_XP_012257972.1_18254 3 Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-6807878 "Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"COPI-mediated anterograde transport" lcl|NW_020311961.1_prot_XP_012262556.1_13516 1 Reactome: R-HSA-5656169 "Termination of translesion DNA synthesis" lcl|NW_020311367.1_prot_XP_012258952.1_6094 4 Reactome: R-HSA-77289;Reactome: R-HSA-6799198;Reactome: R-HSA-389661;Reactome: R-HSA-611105 "Mitochondrial Fatty Acid Beta-Oxidation";"Complex I biogenesis";"Glyoxylate metabolism and glycine degradation";"Respiratory electron transport" lcl|NW_020311373.1_prot_XP_012263104.1_6399 2 Reactome: R-HSA-6791226;Reactome: R-HSA-390471 "Major pathway of rRNA processing in the nucleolus and cytosol";"Association of TriC/CCT with target proteins during biosynthesis" lcl|NW_020311994.1_prot_XP_020711880.1_21619 4 Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436 "COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311988.1_prot_XP_020709734.1_20707 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157 "MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions" lcl|NW_020311407.1_prot_XP_012254808.1_7773 20 MetaCyc: PWY-7574;MetaCyc: PWY-7338;KEGG: 00640+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-735;MetaCyc: PWY-7007;MetaCyc: PWY-7606;MetaCyc: PWY-7854;MetaCyc: PWY-7291;MetaCyc: PWY-7337;MetaCyc: PWY-6837;KEGG: 00592+1.3.3.6;MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6920;MetaCyc: PWY-7288;MetaCyc: PWY-7726;MetaCyc: PWY-7340;MetaCyc: PWY-7858;KEGG: 00410+1.3.3.6 "Propanoyl-coa degradation II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoate metabolism";"Peroxisomal protein import";"Jasmonic acid biosynthesis";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"beta-Alanine metabolism" lcl|NW_020311985.1_prot_XP_012265166.1_20218 3 KEGG: 00520+1.1.1.271;KEGG: 00051+1.1.1.271;Reactome: R-HSA-6787639 "Amino sugar and nucleotide sugar metabolism";"Fructose and mannose metabolism";"GDP-fucose biosynthesis" lcl|NW_020311513.1_prot_XP_012266161.1_9807 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311339.1_prot_XP_012254417.1_4614 13 KEGG: 00983+1.17.4.1;MetaCyc: PWY-7184;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-6545;Reactome: R-HSA-499943;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7222;MetaCyc: PWY-7210;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7226 "Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Interconversion of nucleotide di- and triphosphates";"Glutathione metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I" lcl|NW_020311320.1_prot_XP_020712042.1_3371 5 Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-73772 "NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape" lcl|NW_020311932.1_prot_XP_012257412.1_10724 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311507.1_prot_XP_020709184.1_9627 11 Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418597;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-418594;Reactome: R-HSA-418555;Reactome: R-HSA-432040;Reactome: R-HSA-164378 "Adenylate cyclase activating pathway";"Purine metabolism";"G alpha (z) signalling events";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"PKA activation";"Glucagon signaling in metabolic regulation";"G alpha (i) signalling events";"G alpha (s) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation in glucagon signalling" lcl|NW_020311943.1_prot_XP_012255050.1_11576 1 Reactome: R-HSA-196819 "Vitamin B1 (thiamin) metabolism" lcl|NW_020311966.1_prot_XP_012257238.1_15078 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840 "Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation" lcl|NW_020311398.1_prot_XP_012260408.1_7376 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" lcl|NW_020311300.1_prot_XP_012253156.1_1540 6 Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-72689 "L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits" lcl|NW_020311965.1_prot_XP_012259674.1_14313 8 MetaCyc: PWY-5743;MetaCyc: PWY-6142;MetaCyc: PWY-5789;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5744;MetaCyc: PWY-7117;MetaCyc: PWY-241;MetaCyc: PWY-7115 "3-hydroxypropanoate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Nitrogen metabolism";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type" lcl|NW_020311981.1_prot_XP_012257366.1_19105 1 Reactome: R-HSA-611105 "Respiratory electron transport" lcl|NW_020311315.1_prot_XP_020711112.1_3112 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311980.1_prot_XP_012261334.1_18784 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311940.1_prot_XP_020711264.1_11254 2 Reactome: R-HSA-425393;Reactome: R-HSA-5223345 "Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events" lcl|NW_020311482.1_prot_XP_012257155.1_9473 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311948.1_prot_XP_012253463.1_12049 16 Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-192823 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation" lcl|NW_020311292.1_prot_XP_025601933.1_613 3 Reactome: R-HSA-9634638;Reactome: R-HSA-525793;Reactome: R-HSA-5663220 "Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Myogenesis";"RHO GTPases Activate Formins" lcl|NW_020311974.1_prot_XP_020709392.1_16923 2 Reactome: R-HSA-416993;Reactome: R-HSA-202733 "Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall" lcl|NW_020311439.1_prot_XP_020710762.1_8846 2 Reactome: R-HSA-400253;Reactome: R-HSA-2151201 "Circadian Clock";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311968.1_prot_XP_025602616.1_15447 2 Reactome: R-HSA-8853659;Reactome: R-HSA-5673001 "RET signaling";"RAF/MAP kinase cascade" lcl|NW_020311424.1_prot_XP_012255414.1_8200 2 Reactome: R-HSA-379716;Reactome: R-HSA-2408522 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism" lcl|NW_020311976.1_prot_XP_012253584.1_17235 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311948.1_prot_XP_012253434.1_12034 1 Reactome: R-HSA-2468052 "Establishment of Sister Chromatid Cohesion" lcl|NW_020311290.1_prot_XP_020706829.1_435 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311975.1_prot_XP_012251925.1_17040 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" lcl|NW_020311388.1_prot_XP_012262173.1_6948 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" lcl|NW_020311964.1_prot_XP_025602512.1_13866 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311966.1_prot_XP_012256512.1_14759 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311980.1_prot_XP_012261296.1_18799 5 Reactome: R-HSA-390450;Reactome: R-HSA-389957;Reactome: R-HSA-6814122;Reactome: R-HSA-389960;Reactome: R-HSA-390471 "Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis" lcl|NW_020311367.1_prot_XP_020709016.1_6085 2 MetaCyc: PWY-6502;Reactome: R-HSA-2393930 "8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins" lcl|NW_020311984.1_prot_XP_012254619.1_19907 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" lcl|NW_020311302.1_prot_XP_020710871.1_1677 3 Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961 "Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II" lcl|NW_020311313.1_prot_XP_012261909.1_2790 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" lcl|NW_020311941.1_prot_XP_012253205.1_11446 2 MetaCyc: PWY-7802;MetaCyc: PWY-7799 "N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)" lcl|NW_020311475.1_prot_XP_012253323.1_9379 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311418.1_prot_XP_012261031.1_8044 3 Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807 "Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism" lcl|NW_020311433.1_prot_XP_012264017.1_8611 5 KEGG: 00250+2.6.1.16;MetaCyc: PWY-6749;MetaCyc: PWY-8013;KEGG: 00520+2.6.1.16;Reactome: R-HSA-446210 "Alanine, aspartate and glutamate metabolism";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine" lcl|NW_020311941.1_prot_XP_012253217.1_11408 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311940.1_prot_XP_012265690.1_11253 2 Reactome: R-HSA-5223345;Reactome: R-HSA-425393 "Miscellaneous transport and binding events";"Transport of inorganic cations/anions and amino acids/oligopeptides" lcl|NW_020311984.1_prot_XP_020711933.1_20129 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311964.1_prot_XP_025602538.1_13910 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311980.1_prot_XP_012255729.1_18897 3 Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097 "RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway" lcl|NW_020311292.1_prot_XP_020706870.1_560 4 MetaCyc: PWY-8004;MetaCyc: PWY-7268;KEGG: 00480+1.1.1.49;KEGG: 00030+1.1.1.49 "Entner-Doudoroff pathway I";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism";"Pentose phosphate pathway" lcl|NW_020311978.1_prot_XP_012257742.1_18305 13 KEGG: 00230+3.6.1.9;MetaCyc: PWY-6545;KEGG: 00760+3.6.1.9;KEGG: 00240+3.6.1.9;MetaCyc: PWY-7184;KEGG: 00770+3.6.1.9;MetaCyc: PWY-7821;KEGG: 00740+3.6.1.9;MetaCyc: PWY-7206;Reactome: R-HSA-74259;KEGG: 00500+3.6.1.9;KEGG: 00230+3.6.1.66;MetaCyc: PWY-7187 "Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Nicotinate and nicotinamide metabolism";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pantothenate and CoA biosynthesis";"Tunicamycin biosynthesis";"Riboflavin metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation";"Purine catabolism";"Starch and sucrose metabolism";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II" lcl|NW_020311426.1_prot_XP_012268559.1_8251 2 Reactome: R-HSA-8873719;Reactome: R-HSA-8876198 "RAB geranylgeranylation";"RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311413.1_prot_XP_012254402.1_7906 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311310.1_prot_XP_012255821.1_2423 1 Reactome: R-HSA-5683826 "Surfactant metabolism" lcl|NW_020311297.1_prot_XP_012254118.1_1086 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311348.1_prot_XP_012269848.1_5109 11 Reactome: R-HSA-6785631;Reactome: R-HSA-6811558;Reactome: R-HSA-2219530;Reactome: R-HSA-1227986;Reactome: R-HSA-8863795;Reactome: R-HSA-1963642;Reactome: R-HSA-5673001;Reactome: R-HSA-9664565;Reactome: R-HSA-1250196;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993 "ERBB2 Regulates Cell Motility";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Signaling by ERBB2";"Downregulation of ERBB2 signaling";"PI3K events in ERBB2 signaling";"RAF/MAP kinase cascade";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB2 signaling";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling" lcl|NW_020311978.1_prot_XP_012258090.1_18133 3 Reactome: R-HSA-1369062;Reactome: R-HSA-9029569;Reactome: R-HSA-8964058 "ABC transporters in lipid homeostasis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"HDL remodeling" lcl|NW_020311955.1_prot_XP_020711204.1_12433 6 Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-6791226 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311957.1_prot_XP_020710486.1_12835 2 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase" lcl|NW_020311961.1_prot_XP_012262705.1_13257 4 KEGG: 00730+2.8.1.7;MetaCyc: PWY-7250;Reactome: R-HSA-1362409;Reactome: R-HSA-947581 "Thiamine metabolism";"[2Fe-2S] iron-sulfur cluster biosynthesis";"Mitochondrial iron-sulfur cluster biogenesis";"Molybdenum cofactor biosynthesis" lcl|NW_020311976.1_prot_XP_025602731.1_17274 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311979.1_prot_XP_020709209.1_18554 8 KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Human papillomavirus infection";"Activation of RAC1";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway" lcl|NW_020311966.1_prot_XP_012252944.1_14417 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311943.1_prot_XP_012255220.1_11545 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311940.1_prot_XP_012265622.1_11284 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311349.1_prot_XP_012251159.1_5330 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311993.1_prot_XP_012263442.1_21383 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311286.1_prot_XP_012257034.1_132 9 Reactome: R-HSA-70263;KEGG: 00720+6.4.1.1;MetaCyc: PWY-6142;MetaCyc: PWY-8086;KEGG: 00020+6.4.1.1;Reactome: R-HSA-3371599;KEGG: 00620+6.4.1.1;Reactome: R-HSA-196780;MetaCyc: PWY-6146 "Gluconeogenesis";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Citrate cycle (TCA cycle)";"Defective HLCS causes multiple carboxylase deficiency";"Pyruvate metabolism";"Biotin transport and metabolism";"Methanobacterium thermoautotrophicum biosynthetic metabolism" lcl|NW_020311356.1_prot_XP_025601856.1_5561 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" lcl|NW_020311289.1_prot_XP_012253945.1_368 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311965.1_prot_XP_012259999.1_14268 1 Reactome: R-HSA-8849175 "Threonine catabolism" lcl|NW_020311373.1_prot_XP_012266663.1_6438 8 MetaCyc: PWY-7979;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;KEGG: 00515+2.4.1.109 "Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Mannose type O-glycan biosynthesis" lcl|NW_020311981.1_prot_XP_012257398.1_19025 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311418.1_prot_XP_012260981.1_8017 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311334.1_prot_XP_020711373.1_4377 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" lcl|NW_020311982.1_prot_XP_012264620.1_19375 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" lcl|NW_020311972.1_prot_XP_012267928.1_16269 5 MetaCyc: PWY-5514;KEGG: 00520+3.5.99.6;Reactome: R-HSA-70171;MetaCyc: PWY-6855;MetaCyc: PWY-6906 "UDP-N-acetyl-D-galactosamine biosynthesis II";"Amino sugar and nucleotide sugar metabolism";"Glycolysis";"Chitin degradation I (archaea)";"Chitin derivatives degradation" lcl|NW_020311959.1_prot_XP_020709509.1_13030 2 Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" lcl|NW_020311979.1_prot_XP_012259719.1_18541 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" lcl|NW_020311959.1_prot_XP_012262380.1_13116 4 Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664 "Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation" lcl|NW_020311995.1_prot_XP_012257003.1_21959 3 Reactome: R-HSA-5250924;Reactome: R-HSA-72163;Reactome: R-HSA-72165 "B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" lcl|NW_020311453.1_prot_XP_012252722.1_9078 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311513.1_prot_XP_020711444.1_9716 1 Reactome: R-HSA-2142789 "Ubiquinol biosynthesis" lcl|NW_020311965.1_prot_XP_012259851.1_14052 9 Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73779;Reactome: R-HSA-76042 "RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance" lcl|NW_020311955.1_prot_XP_012265360.1_12467 24 Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-8955332;Reactome: R-HSA-380320;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5626467;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-437239;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-5617833;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-9609736 "HCMV Early Events";"RHO GTPases Activate Formins";"Carboxyterminal post-translational modifications of tubulin";"Recruitment of NuMA to mitotic centrosomes";"Separation of Sister Chromatids";"Aggrephagy";"RHO GTPases activate IQGAPs";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Recycling pathway of L1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Kinesins";"Resolution of Sister Chromatid Cohesion";"Cilium Assembly";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors" lcl|NW_020311975.1_prot_XP_012252546.1_17137 6 KEGG: 04658+3.1.3.16;Reactome: R-HSA-2173788;KEGG: 05235+3.1.3.16;Reactome: R-HSA-400253;KEGG: 04660+3.1.3.16;Reactome: R-HSA-163560 "Th1 and Th2 cell differentiation";"Downregulation of TGF-beta receptor signaling";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Circadian Clock";"T cell receptor signaling pathway";"Triglyceride catabolism" lcl|NW_020311974.1_prot_XP_012259780.1_16738 1 Reactome: R-HSA-72203 "Processing of Capped Intron-Containing Pre-mRNA" lcl|NW_020311983.1_prot_XP_025602868.1_19803 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311959.1_prot_XP_025602473.1_13084 3 Reactome: R-HSA-6783310;Reactome: R-HSA-5689880;Reactome: R-HSA-110314 "Fanconi Anemia Pathway";"Ub-specific processing proteases";"Recognition of DNA damage by PCNA-containing replication complex" lcl|NW_020311317.1_prot_XP_012253035.1_3255 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" lcl|NW_020311401.1_prot_XP_020707804.1_7592 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" lcl|NW_020311289.1_prot_XP_012253824.1_366 9 MetaCyc: PWY-6142;MetaCyc: PWY-5789;MetaCyc: PWY-5743;MetaCyc: PWY-7115;MetaCyc: PWY-7117;MetaCyc: PWY-241;MetaCyc: PWY-5744;KEGG: 00910+4.2.1.1;Reactome: R-HSA-1475029 "Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Glyoxylate assimilation";"Nitrogen metabolism";"Reversible hydration of carbon dioxide" lcl|NW_020311325.1_prot_XP_020706318.1_3676 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" lcl|NW_020311354.1_prot_XP_012260694.1_5476 1 KEGG: 00970+6.1.1.2 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311403.1_prot_XP_012253785.1_7712 10 Reactome: R-HSA-444257;Reactome: R-HSA-442742;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-437239;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1 "RSK activation";"CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Recycling pathway of L1";"mTOR signaling pathway";"Relaxin signaling pathway";"Thermogenesis" lcl|NW_020311373.1_prot_XP_025601924.1_6497 2 Reactome: R-HSA-373080;Reactome: R-HSA-3238698 "Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking" lcl|NW_020311971.1_prot_XP_012260952.1_15924 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" lcl|NW_020311330.1_prot_XP_020712014.1_4032 6 Reactome: R-HSA-163560;KEGG: 04660+3.1.3.16;Reactome: R-HSA-400253;KEGG: 05235+3.1.3.16;Reactome: R-HSA-2173788;KEGG: 04658+3.1.3.16 "Triglyceride catabolism";"T cell receptor signaling pathway";"Circadian Clock";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Downregulation of TGF-beta receptor signaling";"Th1 and Th2 cell differentiation" lcl|NW_020311343.1_prot_XP_020708755.1_4790 14 Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-167158;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-113418 "Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the Early Elongation Complex" lcl|NW_020311354.1_prot_XP_012260720.1_5479 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311979.1_prot_XP_020709147.1_18493 2 Reactome: R-HSA-6802953;Reactome: R-HSA-5658442 "RAS signaling downstream of NF1 loss-of-function variants";"Regulation of RAS by GAPs" lcl|NW_020311918.1_prot_XP_020709829.1_10266 4 Reactome: R-HSA-9614399;Reactome: R-HSA-198693;Reactome: R-HSA-9615017;Reactome: R-HSA-5674400 "Regulation of localization of FOXO transcription factors";"AKT phosphorylates targets in the nucleus";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Constitutive Signaling by AKT1 E17K in Cancer" lcl|NW_020311331.1_prot_XP_012264323.1_4088 4 Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" lcl|NW_020311332.1_prot_XP_012256534.1_4192 14 Reactome: R-HSA-1483191;MetaCyc: PWY-7782;KEGG: 00565+3.1.3.4;Reactome: R-HSA-75109;MetaCyc: PWY-8051;MetaCyc: PWY-6453;KEGG: 00600+3.1.3.4;Reactome: R-HSA-1483213;KEGG: 00561+3.1.3.4;KEGG: 00564+3.1.3.4;MetaCyc: PWY-8052;MetaCyc: PWY-8055;MetaCyc: PWY-8053;Reactome: R-HSA-4419969 "Synthesis of PC";"Plasmalogen biosynthesis";"Ether lipid metabolism";"Triglyceride biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Sphingolipid metabolism";"Synthesis of PE";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"2-arachidonoylglycerol biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"Depolymerisation of the Nuclear Lamina" lcl|NW_020311993.1_prot_XP_012262987.1_21360 12 Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167152;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-6804756 "Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Regulation of TP53 Activity through Phosphorylation" lcl|NW_020311973.1_prot_XP_012258607.1_16599 1 Reactome: R-HSA-8964038 "LDL clearance" lcl|NW_020311423.1_prot_XP_012251568.1_8175 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311932.1_prot_XP_012257426.1_10727 1 Reactome: R-HSA-611105 "Respiratory electron transport" lcl|NW_020311943.1_prot_XP_012255000.1_11650 5 MetaCyc: PWY-6902;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;Reactome: R-HSA-189085 "Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Digestion of dietary carbohydrate" lcl|NW_020311970.1_prot_XP_020709350.1_15591 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311361.1_prot_XP_012261506.1_5787 7 KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1 "Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection" lcl|NW_020311418.1_prot_XP_020709692.1_8043 3 Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807 "Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism" lcl|NW_020311353.1_prot_XP_012255947.1_5446 1 Reactome: R-HSA-416476 "G alpha (q) signalling events" lcl|NW_020311353.1_prot_XP_020708034.1_5406 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311978.1_prot_XP_020708591.1_18359 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311971.1_prot_XP_020710510.1_16058 6 Reactome: R-HSA-3000171;Reactome: R-HSA-1650814;Reactome: R-HSA-8948216;Reactome: R-HSA-8874081;Reactome: R-HSA-1442490;Reactome: R-HSA-2022090 "Non-integrin membrane-ECM interactions";"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization";"MET activates PTK2 signaling";"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures" lcl|NW_020311340.1_prot_XP_012269652.1_4683 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311978.1_prot_XP_012257822.1_18052 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" lcl|NW_020311305.1_prot_XP_012264100.1_1998 1 KEGG: 04150+2.7.11.24 "mTOR signaling pathway" lcl|NW_020311407.1_prot_XP_012255241.1_7784 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311356.1_prot_XP_020711756.1_5554 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" lcl|NW_020311971.1_prot_XP_025602670.1_15839 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311353.1_prot_XP_020707980.1_5391 1 Reactome: R-HSA-880009 "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" lcl|NW_020311981.1_prot_XP_012257437.1_18947 8 Reactome: R-HSA-6804757;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-8866652;Reactome: R-HSA-5689880;Reactome: R-HSA-8948747;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827 "Regulation of TP53 Degradation";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Ub-specific processing proteases";"Regulation of PTEN localization";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)" lcl|NW_020311441.1_prot_XP_012251254.1_8861 30 Reactome: R-HSA-5696400;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-73863;Reactome: R-HSA-2564830;Reactome: R-HSA-6796648;Reactome: R-HSA-73779;Reactome: R-HSA-167246;Reactome: R-HSA-6781827;Reactome: R-HSA-75955;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-76042;Reactome: R-HSA-72086;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-167152;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-112382;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-77075;Reactome: R-HSA-167161 "Dual Incision in GG-NER";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Transcription Termination";"Cytosolic iron-sulfur cluster assembly";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Tat-mediated elongation of the HIV-1 transcript";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Capping";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"Formation of RNA Pol II elongation complex";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Pol II CTD phosphorylation and interaction with CE";"HIV Transcription Initiation" lcl|NW_020311977.1_prot_XP_012253845.1_17569 14 KEGG: 00230+1.17.1.4;MetaCyc: PWY-6607;MetaCyc: PWY-6596;MetaCyc: PWY-5695;KEGG: 00983+1.17.3.2;MetaCyc: PWY-6606;MetaCyc: PWY-6999;Reactome: R-HSA-74259;KEGG: 00232+1.17.3.2;MetaCyc: PWY-6608;MetaCyc: PWY-6538;MetaCyc: PWY-5497;KEGG: 00230+1.17.1.4+1.17.3.2;Reactome: R-HSA-8851680 "Purine metabolism";"Guanosine nucleotides degradation I";"Adenosine nucleotides degradation I";"Inosine 5'-phosphate degradation";"Drug metabolism - other enzymes";"Guanosine nucleotides degradation II";"Theophylline degradation";"Purine catabolism";"Caffeine metabolism";"Guanosine nucleotides degradation III";"Caffeine degradation III (bacteria, via demethylation)";"Purine nucleobases degradation II (anaerobic)";"Purine metabolism";"Butyrophilin (BTN) family interactions" lcl|NW_020311439.1_prot_XP_012264144.1_8845 2 Reactome: R-HSA-2151201;Reactome: R-HSA-400253 "Transcriptional activation of mitochondrial biogenesis";"Circadian Clock" lcl|NW_020311333.1_prot_XP_012255958.1_4263 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311992.1_prot_XP_012266470.1_21291 1 Reactome: R-HSA-70895 "Branched-chain amino acid catabolism" lcl|NW_020311958.1_prot_XP_012260382.1_12906 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" lcl|NW_020311313.1_prot_XP_012261752.1_2946 31 MetaCyc: PWY-7858;MetaCyc: PWY-6113;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-7663;MetaCyc: PWY-8012;MetaCyc: PWY-5971;MetaCyc: PWY-6799;MetaCyc: PWY-5994;MetaCyc: PWY-5989;MetaCyc: PWY-8047;MetaCyc: PWY-7746;MetaCyc: PWY-5966-1;MetaCyc: PWY-6282;MetaCyc: PWY-7664;MetaCyc: PWY-5366;MetaCyc: PWY-8049;MetaCyc: PWY-7723;MetaCyc: PWY-7388;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-9029558;MetaCyc: PWY-5973;Reactome: R-HSA-163765;Reactome: R-HSA-75105;Reactome: R-HSA-199220;MetaCyc: PWY-6519;Reactome: R-HSA-2426168;MetaCyc: PWY-5147;MetaCyc: PWY-5367;MetaCyc: PWY-4381;MetaCyc: PWYG-321;MetaCyc: PWY-5142 "(5Z)-dodecenoate biosynthesis II";"Superpathway of mycolate biosynthesis";"Fatty acid biosynthesis";"Gondoate biosynthesis (anaerobic)";"Mupirocin biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Stearate biosynthesis II (bacteria and plants)";"Bryostatin biosynthesis";"Mycobacterial sulfolipid biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Oleate biosynthesis IV (anaerobic)";"Palmitoleate biosynthesis II (plants and bacteria)";"Pederin biosynthesis";"Bacterial bioluminescence";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Biotin metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Cis-vaccenate biosynthesis";"ChREBP activates metabolic gene expression";"Fatty acyl-CoA biosynthesis";"Vitamin B5 (pantothenate) metabolism";"8-amino-7-oxononanoate biosynthesis I";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis I (plants)";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"";"Acyl-[acyl-carrier protein] thioesterase pathway" lcl|NW_020311957.1_prot_XP_012263334.1_12841 5 Reactome: R-HSA-376172;Reactome: R-HSA-168638;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;KEGG: 04150+2.7.11.24 "DSCAM interactions";"NOD1/2 Signaling Pathway";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"mTOR signaling pathway" lcl|NW_020311559.1_prot_XP_025602217.1_10043 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" lcl|NW_020311995.1_prot_XP_020708188.1_21881 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311292.1_prot_XP_012252389.1_533 19 Reactome: R-HSA-8856828;Reactome: R-HSA-8963888;Reactome: R-HSA-8964026;Reactome: R-HSA-202733;Reactome: R-HSA-8964038;Reactome: R-HSA-8964041;Reactome: R-HSA-8964046;Reactome: R-HSA-3000480;Reactome: R-HSA-8957275;Reactome: R-HSA-8856825;Reactome: R-HSA-8866423;Reactome: R-HSA-5686938;Reactome: R-HSA-381426;Reactome: R-HSA-3000471;Reactome: R-HSA-432142;Reactome: R-HSA-975634;Reactome: R-HSA-8963901;Reactome: R-HSA-3000484;Reactome: R-HSA-3000497 "Clathrin-mediated endocytosis";"Chylomicron assembly";"Chylomicron clearance";"Cell surface interactions at the vascular wall";"LDL clearance";"LDL remodeling";"VLDL clearance";"Scavenging by Class A Receptors";"Post-translational protein phosphorylation";"Cargo recognition for clathrin-mediated endocytosis";"VLDL assembly";"Regulation of TLR by endogenous ligand";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Scavenging by Class B Receptors";"Platelet sensitization by LDL";"Retinoid metabolism and transport";"Chylomicron remodeling";"Scavenging by Class F Receptors";"Scavenging by Class H Receptors" lcl|NW_020311432.1_prot_XP_012268925.1_8559 2 Reactome: R-HSA-418594;Reactome: R-HSA-6814122 "G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" lcl|NW_020311966.1_prot_XP_012256470.1_14881 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311994.1_prot_XP_012267547.1_21692 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" lcl|NW_020311966.1_prot_XP_012252987.1_14528 1 Reactome: R-HSA-373752 "Netrin-1 signaling" lcl|NW_020311316.1_prot_XP_020712358.1_3157 7 MetaCyc: PWY-7219;MetaCyc: PWY-6124;KEGG: 00230+4.3.2.2;KEGG: 00250+4.3.2.2;MetaCyc: PWY-7234;Reactome: R-HSA-73817;MetaCyc: PWY-6123 "Adenosine ribonucleotides de novo biosynthesis";"Inosine-5'-phosphate biosynthesis II";"Purine metabolism";"Alanine, aspartate and glutamate metabolism";"Inosine-5'-phosphate biosynthesis III";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis I" lcl|NW_020311966.1_prot_XP_020708135.1_14882 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311977.1_prot_XP_020707340.1_17557 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311286.1_prot_XP_012256566.1_164 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311321.1_prot_XP_012263211.1_3404 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311990.1_prot_XP_012266582.1_20835 2 KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336 "Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway" lcl|NW_020311304.1_prot_XP_012261048.1_1923 2 MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11 "L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311294.1_prot_XP_020711014.1_880 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" lcl|NW_020311967.1_prot_XP_012254279.1_15286 7 MetaCyc: PWY-5188;Reactome: R-HSA-6782315;KEGG: 00970+6.1.1.15;Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00860+6.1.1.17;KEGG: 00970+6.1.1.17 "Tetrapyrrole biosynthesis I (from glutamate)";"tRNA modification in the nucleus and cytosol";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Porphyrin and chlorophyll metabolism";"Aminoacyl-tRNA biosynthesis" lcl|NW_020311967.1_prot_XP_025602605.1_15247 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311976.1_prot_XP_012253619.1_17277 18 KEGG: 00620+1.1.1.37;Reactome: R-HSA-70263;MetaCyc: PWY-7383;MetaCyc: PWY-8086;MetaCyc: PWY-1622;MetaCyc: PWY-5913;KEGG: 00270+1.1.1.37;MetaCyc: PWY-7115;KEGG: 00020+1.1.1.37;KEGG: 00680+1.1.1.37;KEGG: 00630+1.1.1.37;MetaCyc: PWY-6969;MetaCyc: PWY-5392;MetaCyc: PWY-6728;MetaCyc: PWY-5690;KEGG: 00710+1.1.1.37;KEGG: 00720+1.1.1.37;MetaCyc: PWY-561 "Pyruvate metabolism";"Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Formaldehyde assimilation I (serine pathway)";"Partial TCA cycle (obligate autotrophs)";"Cysteine and methionine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Citrate cycle (TCA cycle)";"Methane metabolism";"Glyoxylate and dicarboxylate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Carbon fixation in photosynthetic organisms";"Carbon fixation pathways in prokaryotes";"Superpathway of glyoxylate cycle and fatty acid degradation" lcl|NW_020311918.1_prot_XP_020710235.1_10302 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" lcl|NW_020311321.1_prot_XP_012263209.1_3413 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" lcl|NW_020311971.1_prot_XP_012260826.1_15848 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" lcl|NW_020311955.1_prot_XP_012265323.1_12483 6 KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23 "Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Galactose metabolism" lcl|NW_020311976.1_prot_XP_020707243.1_17296 5 Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-917729;Reactome: R-HSA-162588 "Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion" lcl|NW_020311365.1_prot_XP_012269335.1_5997 4 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription" lcl|NW_020311347.1_prot_XP_012266243.1_5042 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311388.1_prot_XP_020710950.1_6996 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" lcl|NW_020311940.1_prot_XP_012265518.1_11167 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" lcl|NW_020311968.1_prot_XP_020707042.1_15441 2 Reactome: R-HSA-5576894;Reactome: R-HSA-1296072 "Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels" lcl|NW_020311970.1_prot_XP_012267422.1_15803 6 Reactome: R-HSA-8957275;Reactome: R-HSA-8963889;Reactome: R-HSA-8874211;Reactome: R-HSA-1655829;Reactome: R-HSA-381033;Reactome: R-HSA-381426 "Post-translational protein phosphorylation";"Assembly of active LPL and LIPC lipase complexes";"CREB3 factors activate genes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"ATF6 (ATF6-alpha) activates chaperones";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" lcl|NW_020311917.1_prot_XP_012250975.1_10256 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311977.1_prot_XP_012263757.1_17649 1 Reactome: R-HSA-6811438 "Intra-Golgi traffic" lcl|NW_020311941.1_prot_XP_012253220.2_11415 1 Reactome: R-HSA-8851805 "MET activates RAS signaling" lcl|NW_020311917.1_prot_XP_012250985.1_10249 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311975.1_prot_XP_012251307.1_16943 1 Reactome: R-HSA-6798163 "Choline catabolism" lcl|NW_020311968.1_prot_XP_012266024.1_15502 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311290.1_prot_XP_020706936.1_442 3 Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840 "G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle" lcl|NW_020311304.1_prot_XP_012260426.1_1944 3 Reactome: R-HSA-9609523;Reactome: R-HSA-1799339;Reactome: R-HSA-1236974 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"SRP-dependent cotranslational protein targeting to membrane";"ER-Phagosome pathway" lcl|NW_020311294.1_prot_XP_012264943.1_860 5 MetaCyc: PWY-5084;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2 "2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism";"Lysine degradation";"Citrate cycle (TCA cycle)" lcl|NW_020311367.1_prot_XP_012258938.1_6092 33 Reactome: R-HSA-168271;Reactome: R-HSA-3371453;Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-168325;Reactome: R-HSA-170822;Reactome: R-HSA-159230;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-4085377;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-5663220;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-9648025;Reactome: R-HSA-168276;Reactome: R-HSA-6784531;Reactome: R-HSA-68877;Reactome: R-HSA-4551638;Reactome: R-HSA-5619107;Reactome: R-HSA-159236;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;Reactome: R-HSA-4615885;Reactome: R-HSA-2467813;Reactome: R-HSA-191859;Reactome: R-HSA-5578749 "Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Viral Messenger RNA Synthesis";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP Dependant Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"SUMOylation of SUMOylation proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"ISG15 antiviral mechanism";"RHO GTPases Activate Formins";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"EML4 and NUDC in mitotic spindle formation";"NS1 Mediated Effects on Host Pathways";"tRNA processing in the nucleus";"Mitotic Prometaphase";"SUMOylation of chromatin organization proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of DNA replication proteins";"Separation of Sister Chromatids";"snRNP Assembly";"Transcriptional regulation by small RNAs" lcl|NW_020311300.1_prot_XP_012253236.1_1536 1 Reactome: R-HSA-6811436 "COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311401.1_prot_XP_012255323.1_7523 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" lcl|NW_020311980.1_prot_XP_012255749.1_18907 29 Reactome: R-HSA-5696400;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-6796648;Reactome: R-HSA-73863;Reactome: R-HSA-6781827;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-5696395;Reactome: R-HSA-167158;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-73772;Reactome: R-HSA-167161 "Dual Incision in GG-NER";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"mRNA Capping";"Formation of RNA Pol II elongation complex";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of Incision Complex in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"RNA Polymerase I Promoter Escape";"HIV Transcription Initiation" lcl|NW_020311974.1_prot_XP_012259934.1_16829 3 MetaCyc: PWY-6987;MetaCyc: PWY-7382;KEGG: 00785+2.3.1.181 "Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism" lcl|NW_020311317.1_prot_XP_012254763.1_3195 14 MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-7602;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-8041 "Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Fatty acid elongation";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis" lcl|NW_020311386.1_prot_XP_012253231.1_6929 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" lcl|NW_020311992.1_prot_XP_012260878.1_20961 1 Reactome: R-HSA-3295583 "TRP channels" lcl|NW_020311373.1_prot_XP_020711639.1_6480 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311340.1_prot_XP_012258133.1_4669 5 KEGG: 00230+3.6.1.6;Reactome: R-HSA-6798695;MetaCyc: PWY-7185;MetaCyc: PWY-7210;KEGG: 00240+3.6.1.6 "Purine metabolism";"Neutrophil degranulation";"UTP and CTP dephosphorylation I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism" lcl|NW_020311966.1_prot_XP_012257237.1_15077 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" lcl|NW_020311982.1_prot_XP_012258419.1_19196 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" lcl|NW_020311940.1_prot_XP_012265646.1_11242 14 KEGG: 00062+2.3.1.199;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7619;MetaCyc: PWY-5972;MetaCyc: PWY-7601;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-6598;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7725 "Fatty acid elongation";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Sciadonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)" lcl|NW_020311977.1_prot_XP_012263701.1_17667 16 Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9633012 "L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency" lcl|NW_020311918.1_prot_XP_012268263.2_10305 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" lcl|NW_020311513.1_prot_XP_012266131.1_9861 29 KEGG: 04150+2.7.11.1;Reactome: R-HSA-6796648;Reactome: R-HSA-69541;Reactome: R-HSA-6803207;Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6804757;Reactome: R-HSA-912446;Reactome: R-HSA-5693568;Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-2559586;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693554;Reactome: R-HSA-349425;Reactome: R-HSA-5693548;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693616;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-6804760;Reactome: R-HSA-3371453;Reactome: R-HSA-6803204;Reactome: R-HSA-5685938;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5685942 "mTOR signaling pathway";"TP53 Regulates Transcription of DNA Repair Genes";"Stabilization of p53";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"Thermogenesis";"Regulation of TP53 Degradation";"Meiotic recombination";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"DNA Damage/Telomere Stress Induced Senescence";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Autodegradation of the E3 ubiquitin ligase COP1";"Sensing of DNA Double Strand Breaks";"Relaxin signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Methylation";"Regulation of HSF1-mediated heat shock response";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"HDR through Single Strand Annealing (SSA)";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"HDR through Homologous Recombination (HRR)" lcl|NW_020311441.1_prot_XP_012251244.1_8890 3 KEGG: 00860+1.3.3.4;MetaCyc: PWY-7159;Reactome: R-HSA-189451 "Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis" lcl|NW_020311342.1_prot_XP_012255765.1_4750 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" lcl|NW_020311983.1_prot_XP_012268327.1_19558 7 Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061 "RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" lcl|NW_020311976.1_prot_XP_020707244.1_17243 2 Reactome: R-HSA-8866907;Reactome: R-HSA-8866904 "Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors" lcl|NW_020311957.1_prot_XP_012262069.1_12750 4 Reactome: R-HSA-73817;MetaCyc: PWY-7221;KEGG: 00230+6.3.5.2;KEGG: 00983+6.3.5.2 "Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Drug metabolism - other enzymes" lcl|NW_020311316.1_prot_XP_012269017.1_3164 2 KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085 "Starch and sucrose metabolism";"Digestion of dietary carbohydrate" lcl|NW_020311917.1_prot_XP_012251534.1_10199 17 Reactome: R-HSA-167242;Reactome: R-HSA-167238;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-6796648;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-167158;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-167246;KEGG: 04660+3.1.3.16;Reactome: R-HSA-113418 "Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"T cell receptor signaling pathway";"Formation of the Early Elongation Complex" lcl|NW_020311365.1_prot_XP_012269441.1_6031 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" lcl|NW_020311964.1_prot_XP_012261657.1_13963 6 Reactome: R-HSA-72165;Reactome: R-HSA-191859;Reactome: R-HSA-77588;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-111367 "mRNA Splicing - Minor Pathway";"snRNP Assembly";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"SLBP independent Processing of Histone Pre-mRNAs" lcl|NW_020311424.1_prot_XP_020707854.1_8177 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311955.1_prot_XP_012265413.1_12513 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" lcl|NW_020311433.1_prot_XP_012263834.1_8615 16 Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-72689 "SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits" lcl|NW_020311943.1_prot_XP_012255279.1_11624 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311977.1_prot_XP_012263844.1_17740 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" lcl|NW_020311978.1_prot_XP_012257761.1_18199 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" lcl|NW_020311382.1_prot_XP_012268014.1_6857 8 MetaCyc: PWY-6174;MetaCyc: PWY-7524;KEGG: 00900+1.1.1.34;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-191273;MetaCyc: PWY-922;MetaCyc: PWY-7391 "Mevalonate pathway II (archaea)";"Mevalonate pathway III (archaea)";"Terpenoid backbone biosynthesis";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"Cholesterol biosynthesis";"Mevalonate pathway I";"Isoprene biosynthesis II (engineered)" lcl|NW_020311299.1_prot_XP_012263180.1_1476 1 KEGG: 00970+6.1.1.21 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311419.1_prot_XP_020707408.1_8071 1 Reactome: R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" lcl|NW_020311983.1_prot_XP_012255532.1_19651 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" lcl|NW_020311977.1_prot_XP_020710647.1_17793 17 MetaCyc: PWY-5789;MetaCyc: PWY-5743;KEGG: 00620+6.4.1.2;MetaCyc: PWY-6722;KEGG: 00061+6.4.1.2;MetaCyc: PWY-5744;KEGG: 00720+6.4.1.2;MetaCyc: PWY-5966-1;Reactome: R-HSA-3371599;Reactome: R-HSA-163765;Reactome: R-HSA-2426168;Reactome: R-HSA-200425;KEGG: 00254+6.4.1.2;KEGG: 00640+6.4.1.2;Reactome: R-HSA-196780;MetaCyc: PWY-6679;MetaCyc: PWY-4381 "3-hydroxypropanoate/4-hydroxybutanate cycle";"3-hydroxypropanoate cycle";"Pyruvate metabolism";"Candicidin biosynthesis";"Fatty acid biosynthesis";"Glyoxylate assimilation";"Carbon fixation pathways in prokaryotes";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Defective HLCS causes multiple carboxylase deficiency";"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)";"Carnitine metabolism";"Aflatoxin biosynthesis";"Propanoate metabolism";"Biotin transport and metabolism";"Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)" lcl|NW_020311966.1_prot_XP_012253679.1_14508 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311454.1_prot_XP_012252280.1_9099 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311346.1_prot_XP_012262955.1_4958 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" lcl|NW_020311311.1_prot_XP_012250887.1_2447 10 MetaCyc: PWY-7559;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-5826;MetaCyc: PWY-7112;MetaCyc: PWY-6842;MetaCyc: PWY-8001;MetaCyc: PWY-4041 "Glutathione degradation (DUG pathway";"Cyanoamino acid metabolism";"Glutathione-mediated detoxification I";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"Hypoglycin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification II";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Gamma-glutamyl cycle" lcl|NW_020311373.1_prot_XP_020710380.1_6407 1 Reactome: R-HSA-111957 "Cam-PDE 1 activation" lcl|NW_020311511.1_prot_XP_012250943.1_9671 56 Reactome: R-HSA-68827;Reactome: R-HSA-174178;Reactome: R-HSA-5610785;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-8941858;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-9010553;Reactome: R-HSA-2871837;Reactome: R-HSA-180585;Reactome: R-HSA-1169091;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-69601;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-174084;Reactome: R-HSA-69481;Reactome: R-HSA-5658442;Reactome: R-HSA-1236978;Reactome: R-HSA-69017;Reactome: R-HSA-8852276;Reactome: R-HSA-187577;Reactome: R-HSA-450408;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-211733;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-8948751;Reactome: R-HSA-174113;Reactome: R-HSA-202424;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-5607761;Reactome: R-HSA-174154;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-350562;Reactome: R-HSA-68949 "CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"GLI3 is processed to GLI3R by the proteasome";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Regulation of RUNX3 expression and activity";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of expression of SLITs and ROBOs";"FCERI mediated NF-kB activation";"Vif-mediated degradation of APOBEC3G";"Activation of NF-kappaB in B cells";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"Degradation of AXIN";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"G2/M Checkpoints";"Regulation of RAS by GAPs";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDK-mediated phosphorylation and removal of Cdc6";"The role of GTSE1 in G2/M progression after G2 checkpoint";"SCF(Skp2)-mediated degradation of p27/p21";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"UCH proteinases";"Hedgehog 'on' state";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Regulation of PTEN stability and activity";"SCF-beta-TrCP mediated degradation of Emi1";"Downstream TCR signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdc20 mediated degradation of Securin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of ornithine decarboxylase (ODC)";"Orc1 removal from chromatin" lcl|NW_020311966.1_prot_XP_012256956.1_14725 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311934.1_prot_XP_012255134.1_10809 2 KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386 "Pyruvate metabolism";"Methylglyoxal degradation I" lcl|NW_020311967.1_prot_XP_012256017.1_15262 9 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-198323;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"AKT phosphorylates targets in the cytosol";"Human papillomavirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway" lcl|NW_020311915.1_prot_XP_012262250.1_10165 2 Reactome: R-HSA-9010553;Reactome: R-HSA-975957 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311306.1_prot_XP_012264211.1_2105 6 KEGG: 00052+2.7.7.12;MetaCyc: PWY-6527;MetaCyc: PWY-6317;KEGG: 00520+2.7.7.12;Reactome: R-HSA-5609978;Reactome: R-HSA-70370 "Galactose metabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism";"Defective GALT can cause Galactosemia";"Galactose catabolism" lcl|NW_020311323.1_prot_XP_012268108.1_3509 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311993.1_prot_XP_012262930.1_21377 3 KEGG: 00534+5.1.3.17;MetaCyc: PWY-6558;Reactome: R-HSA-2022928 "Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis" lcl|NW_020311304.1_prot_XP_012261419.1_1896 1 MetaCyc: PWY-7511 "Protein ubiquitination" lcl|NW_020311983.1_prot_XP_012255651.1_19722 12 Reactome: R-HSA-380259;Reactome: R-HSA-3371497;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-381038;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-2132295;Reactome: R-HSA-380284 "Loss of Nlp from mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"XBP1(S) activates chaperone genes";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"MHC class II antigen presentation";"Loss of proteins required for interphase microtubule organization from the centrosome" lcl|NW_020311296.1_prot_XP_012265439.1_1007 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" lcl|NW_020311292.1_prot_XP_012262799.1_706 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311292.1_prot_XP_012252381.1_663 1 Reactome: R-HSA-1632852 "Macroautophagy" lcl|NW_020311976.1_prot_XP_020707259.1_17284 2 KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749 "Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I" lcl|NW_020311988.1_prot_XP_012260520.1_20560 5 MetaCyc: PWY-5084;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2 "2-oxoglutarate decarboxylation to succinyl-CoA";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism";"Citrate cycle (TCA cycle)" lcl|NW_020311946.1_prot_XP_012268769.1_11890 16 Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-8853884;Reactome: R-HSA-174048;Reactome: R-HSA-2467813;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-179409;Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-141430 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of Cyclin B";"Separation of Sister Chromatids";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"APC-Cdc20 mediated degradation of Nek2A";"Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"Inactivation of APC/C via direct inhibition of the APC/C complex" lcl|NW_020311343.1_prot_XP_012258267.1_4783 3 Reactome: R-HSA-6798695;Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311986.1_prot_XP_012258900.1_20324 1 Reactome: R-HSA-2564830 "Cytosolic iron-sulfur cluster assembly" lcl|NW_020311985.1_prot_XP_012265234.1_20196 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311956.1_prot_XP_020707558.1_12583 4 Reactome: R-HSA-983189;Reactome: R-HSA-5625970;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434 "Kinesins";"RHO GTPases activate KTN1";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311983.1_prot_XP_012267225.1_19494 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" lcl|NW_020311339.1_prot_XP_012254006.1_4609 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" lcl|NW_020311971.1_prot_XP_020710527.1_16079 12 Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436 "Mitotic Prometaphase";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311978.1_prot_XP_020708586.1_18354 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" lcl|NW_020311955.1_prot_XP_020711144.1_12382 10 Reactome: R-HSA-5609977;MetaCyc: PWY-6317;MetaCyc: PWY-6527;MetaCyc: PWY-6397;MetaCyc: PWY-3821;Reactome: R-HSA-70370;MetaCyc: PWY-7328;MetaCyc: PWY-7344;KEGG: 00052+5.1.3.2;KEGG: 00520+5.1.3.2 "Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose detoxification";"Galactose catabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"UDP-alpha-D-galactose biosynthesis";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism" lcl|NW_020311981.1_prot_XP_012257469.1_18975 3 Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400 "Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Dual Incision in GG-NER" lcl|NW_020311973.1_prot_XP_012258604.1_16356 6 Reactome: R-HSA-8950505;MetaCyc: PWY-6854;Reactome: R-HSA-2151201;Reactome: R-HSA-8862803;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685 "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Ethylene biosynthesis III (microbes)";"Transcriptional activation of mitochondrial biogenesis";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species" lcl|NW_020311947.1_prot_XP_020709551.1_11963 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" lcl|NW_020311306.1_prot_XP_012264132.1_2048 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311973.1_prot_XP_020708867.1_16360 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311373.1_prot_XP_012266724.1_6476 3 KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation" lcl|NW_020311918.1_prot_XP_020709853.1_10268 4 Reactome: R-HSA-9615017;Reactome: R-HSA-5674400;Reactome: R-HSA-198693;Reactome: R-HSA-9614399 "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Constitutive Signaling by AKT1 E17K in Cancer";"AKT phosphorylates targets in the nucleus";"Regulation of localization of FOXO transcription factors" lcl|NW_020311937.1_prot_XP_012252649.1_11028 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" lcl|NW_020311323.1_prot_XP_012268044.1_3479 3 Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-5689877 "DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"Josephin domain DUBs" lcl|NW_020311971.1_prot_XP_012260899.1_15923 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311971.1_prot_XP_012263509.1_16053 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311964.1_prot_XP_020709980.1_14017 4 MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.32;KEGG: 00592+3.1.1.32 "Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism" lcl|NW_020311985.1_prot_XP_012253974.1_20298 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" lcl|NW_020311988.1_prot_XP_012262937.1_20473 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" lcl|NW_020311305.1_prot_XP_020710644.1_1994 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" lcl|NW_020311292.1_prot_XP_012252583.1_626 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" lcl|NW_020311974.1_prot_XP_020709405.1_16867 1 Reactome: R-HSA-446210 "Synthesis of UDP-N-acetyl-glucosamine" lcl|NW_020311333.1_prot_XP_012256065.1_4291 4 Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript" lcl|NW_020311324.1_prot_XP_012269458.1_3542 2 Reactome: R-HSA-418990;Reactome: R-HSA-5218920 "Adherens junctions interactions";"VEGFR2 mediated vascular permeability" lcl|NW_020311315.1_prot_XP_012265243.1_3126 2 Reactome: R-HSA-1660662;Reactome: R-HSA-1663150 "Glycosphingolipid metabolism";"The activation of arylsulfatases" lcl|NW_020311980.1_prot_XP_012255731.1_18894 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" lcl|NW_020311286.1_prot_XP_012256943.1_77 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" lcl|NW_020311353.1_prot_XP_012256053.1_5411 3 Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067 "Glycogen synthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)" lcl|NW_020311988.1_prot_XP_012255188.1_20509 2 Reactome: R-HSA-70895;KEGG: 00280+1.3.8.4 "Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation" lcl|NW_020311397.1_prot_XP_012253759.1_7355 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" lcl|NW_020311958.1_prot_XP_025602458.1_12985 13 Reactome: R-HSA-5607763;Reactome: R-HSA-2029485;Reactome: R-HSA-422356;Reactome: R-HSA-1489509;Reactome: R-HSA-114508;Reactome: R-HSA-2871809;Reactome: R-HSA-5578775;Reactome: R-HSA-5218921;Reactome: R-HSA-112043;Reactome: R-HSA-4086398;Reactome: R-HSA-983695;Reactome: R-HSA-381676;Reactome: R-HSA-139853 "CLEC7A (Dectin-1) induces NFAT activation";"Role of phospholipids in phagocytosis";"Regulation of insulin secretion";"DAG and IP3 signaling";"Effects of PIP2 hydrolysis";"FCERI mediated Ca+2 mobilization";"Ion homeostasis";"VEGFR2 mediated cell proliferation";"PLC beta mediated events";"Ca2+ pathway";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Elevation of cytosolic Ca2+ levels" lcl|NW_020311472.1_prot_XP_025602156.1_9338 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" lcl|NW_020311292.1_prot_XP_012252558.1_634 3 MetaCyc: PWY-7159;KEGG: 00860+1.3.3.3;Reactome: R-HSA-189451 "3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis" lcl|NW_020311365.1_prot_XP_020712483.1_5988 4 Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" lcl|NW_020311313.1_prot_XP_012261865.1_2894 2 KEGG: 04660+2.7.10.2;Reactome: R-HSA-428890 "T cell receptor signaling pathway";"Role of ABL in ROBO-SLIT signaling" lcl|NW_020311354.1_prot_XP_025601846.1_5469 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311397.1_prot_XP_012253736.1_7349 3 MetaCyc: PWY-4261;Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30 "Glycerol degradation I";"Triglyceride biosynthesis";"Glycerolipid metabolism" lcl|NW_020311990.1_prot_XP_012266791.1_20831 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" lcl|NW_020311962.1_prot_XP_012252153.1_13736 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" lcl|NW_020311978.1_prot_XP_012258046.1_18288 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311964.1_prot_XP_025602540.1_13906 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" lcl|NW_020311957.1_prot_XP_012262121.1_12731 1 Reactome: R-HSA-194840 "Rho GTPase cycle" lcl|NW_020311985.1_prot_XP_012265237.1_20199 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" lcl|NW_020311513.1_prot_XP_020711389.1_9889 6 MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952 "Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)" lcl|NW_020311994.1_prot_XP_020711830.1_21806 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" lcl|NW_020311966.1_prot_XP_012256571.1_14835 1 Reactome: R-HSA-6799198 "Complex I biogenesis" lcl|NW_020311977.1_prot_XP_012253795.1_17507 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" lcl|NW_020311984.1_prot_XP_012254575.1_19995 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" lcl|NW_020311941.1_prot_XP_012253215.1_11411 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311994.1_prot_XP_012267492.1_21549 9 Reactome: R-HSA-70171;MetaCyc: PWY-5484;KEGG: 00010+1.2.1.12;KEGG: 00710+1.2.1.12;Reactome: R-HSA-70263;MetaCyc: PWY-6901;MetaCyc: PWY-1042;MetaCyc: PWY-7003;MetaCyc: PWY-8004 "Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Glycolysis IV (plant cytosol)";"Glycerol degradation to butanol";"Entner-Doudoroff pathway I" lcl|NW_020311313.1_prot_XP_012261850.1_2851 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311977.1_prot_XP_012263678.1_17797 17 MetaCyc: PWY-5789;KEGG: 00620+6.4.1.2;MetaCyc: PWY-5743;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6722;KEGG: 00720+6.4.1.2;MetaCyc: PWY-5966-1;MetaCyc: PWY-5744;Reactome: R-HSA-163765;Reactome: R-HSA-3371599;KEGG: 00254+6.4.1.2;Reactome: R-HSA-2426168;Reactome: R-HSA-200425;Reactome: R-HSA-196780;KEGG: 00640+6.4.1.2;MetaCyc: PWY-6679;MetaCyc: PWY-4381 "3-hydroxypropanoate/4-hydroxybutanate cycle";"Pyruvate metabolism";"3-hydroxypropanoate cycle";"Fatty acid biosynthesis";"Candicidin biosynthesis";"Carbon fixation pathways in prokaryotes";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Glyoxylate assimilation";"ChREBP activates metabolic gene expression";"Defective HLCS causes multiple carboxylase deficiency";"Aflatoxin biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Carnitine metabolism";"Biotin transport and metabolism";"Propanoate metabolism";"Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)" lcl|NW_020311392.1_prot_XP_012250930.1_7070 1 Reactome: R-HSA-8949664 "Processing of SMDT1" lcl|NW_020311286.1_prot_XP_012256272.1_153 14 MetaCyc: PWY-7587;MetaCyc: PWY-5667;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-7417;MetaCyc: PWY-7589;MetaCyc: PWY-7411;MetaCyc: PWY-5981;MetaCyc: PWY-8055;MetaCyc: PWY-8053 "Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Glycerolipid metabolism";"Plasmalogen biosynthesis";"Synthesis of PA";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Palmitoleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II" lcl|NW_020311354.1_prot_XP_012260709.1_5491 13 KEGG: 00562+3.1.4.11;Reactome: R-HSA-2424491;MetaCyc: PWY-7039;Reactome: R-HSA-9027277;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11;Reactome: R-HSA-2871796;MetaCyc: PWY-6367;Reactome: R-HSA-2029485;MetaCyc: PWY-8052;Reactome: R-HSA-2871809;MetaCyc: PWY-6351;Reactome: R-HSA-202433 "Inositol phosphate metabolism";"DAP12 signaling";"Phosphatidate metabolism, as a signaling molecule";"Erythropoietin activates Phospholipase C gamma (PLCG)";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"FCERI mediated MAPK activation";"D-myo-inositol-5-phosphate metabolism";"Role of phospholipids in phagocytosis";"2-arachidonoylglycerol biosynthesis";"FCERI mediated Ca+2 mobilization";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Generation of second messenger molecules" lcl|NW_020311340.1_prot_XP_012269636.1_4688 16 Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72689 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits" lcl|NW_020311401.1_prot_XP_012255063.1_7636 16 Reactome: R-HSA-2559580;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-9029569;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-8934593;Reactome: R-HSA-8943723;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459;Reactome: R-HSA-2559585 "Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"Regulation of RUNX1 Expression and Activity";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Oncogene Induced Senescence" lcl|NW_020311978.1_prot_XP_020708556.1_18086 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" lcl|NW_020311977.1_prot_XP_020710663.1_17780 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" lcl|NW_020311332.1_prot_XP_012268547.1_4140 1 KEGG: 00970+6.1.1.9 "Aminoacyl-tRNA biosynthesis" lcl|NW_020311321.1_prot_XP_020710391.1_3433 2 Reactome: R-HSA-3928665;Reactome: R-HSA-2682334 "EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling" lcl|NW_020311992.1_prot_XP_012266553.1_21260 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" lcl|NW_020311358.1_prot_XP_012255945.1_5674 1 Reactome: R-HSA-191859 "snRNP Assembly" lcl|NW_020311967.1_prot_XP_012254262.1_15306 11 Reactome: R-HSA-163615;Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-418597;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-163359 "PKA activation";"Adenylate cyclase activating pathway";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"G alpha (z) signalling events";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Glucagon signaling in metabolic regulation" lcl|NW_020311980.1_prot_XP_012261237.2_18801 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311971.1_prot_XP_020710488.1_16061 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" lcl|NW_020311964.1_prot_XP_025602514.1_13869 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" lcl|NW_020311959.1_prot_XP_012262296.1_13093 5 MetaCyc: PWY-5083;MetaCyc: PWY-7268;MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807 "NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism" lcl|NW_020311925.1_prot_XP_020708901.1_10509 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" lcl|NW_020311313.1_prot_XP_012261863.1_2902 1 Reactome: R-HSA-3214847 "HATs acetylate histones" lcl|NW_020311401.1_prot_XP_012254957.1_7613 3 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Tight junction interactions" lcl|NW_020311983.1_prot_XP_012267244.1_19407 1 Reactome: R-HSA-203754 "NOSIP mediated eNOS trafficking" lcl|NW_020311974.1_prot_XP_012260278.1_16707 27 Reactome: R-HSA-72187;Reactome: R-HSA-111367;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-73856;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-167242;Reactome: R-HSA-77588;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-72163;Reactome: R-HSA-72086;Reactome: R-HSA-6803529;Reactome: R-HSA-159236;Reactome: R-HSA-77595;Reactome: R-HSA-159230;Reactome: R-HSA-167200;Reactome: R-HSA-159227;Reactome: R-HSA-975956;Reactome: R-HSA-674695;Reactome: R-HSA-8851708;Reactome: R-HSA-72165;Reactome: R-HSA-112382;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-167158 "mRNA 3'-end processing";"SLBP independent Processing of Histone Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"RNA Polymerase II Transcription Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Abortive elongation of HIV-1 transcript in the absence of Tat";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"mRNA Splicing - Major Pathway";"mRNA Capping";"FGFR2 alternative splicing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Processing of Intronless Pre-mRNAs";"Transport of the SLBP Dependant Mature mRNA";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Transport of the SLBP independent Mature mRNA";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"RNA Polymerase II Pre-transcription Events";"Signaling by FGFR2 IIIa TM";"mRNA Splicing - Minor Pathway";"Formation of RNA Pol II elongation complex";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of the HIV-1 Early Elongation Complex" lcl|NW_020311298.1_prot_XP_020706239.1_1163 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" lcl|NW_020311994.1_prot_XP_012267349.1_21620 4 Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic" lcl|NW_020311981.1_prot_XP_012257396.1_19023 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" lcl|NW_020311956.1_prot_XP_012251357.1_12630 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276 "Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination" lcl|NW_020311334.1_prot_XP_012265941.1_4339 3 Reactome: R-HSA-75109;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Triglyceride biosynthesis";"Glycerol degradation I";"Glycerolipid metabolism" lcl|NW_020311397.1_prot_XP_012258190.1_7293 3 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases" lcl|NW_020311309.1_prot_XP_012259162.2_2319 9 KEGG: 04151+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"tRNA modification in the nucleus and cytosol";"Human papillomavirus infection";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Regulation of TP53 Activity through Phosphorylation";"mTOR signaling pathway";"Relaxin signaling pathway";"Thermogenesis" lcl|NW_020311973.1_prot_XP_012258625.1_16476 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" lcl|NW_020311947.1_prot_XP_012260480.1_11967 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" lcl|NW_020311984.1_prot_XP_012254516.1_19999 5 KEGG: 00760+6.3.4.21;MetaCyc: PWY-5381;Reactome: R-HSA-1368108;Reactome: R-HSA-197264;Reactome: R-HSA-6798695 "Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinamide salvaging";"Neutrophil degranulation" lcl|NW_020311475.1_prot_XP_012253319.1_9397 16 Reactome: R-HSA-6811558;Reactome: R-HSA-2219530;Reactome: R-HSA-389357;Reactome: R-HSA-1433557;Reactome: R-HSA-1660499;Reactome: R-HSA-1257604;Reactome: R-HSA-9009391;Reactome: R-HSA-1266695;Reactome: R-HSA-388841;Reactome: R-HSA-416476;Reactome: R-HSA-912526;Reactome: R-HSA-912631;Reactome: R-HSA-114604;Reactome: R-HSA-8853659;Reactome: R-HSA-194840;Reactome: R-HSA-512988 "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"CD28 dependent PI3K/Akt signaling";"Signaling by SCF-KIT";"Synthesis of PIPs at the plasma membrane";"PIP3 activates AKT signaling";"Extra-nuclear estrogen signaling";"Interleukin-7 signaling";"Costimulation by the CD28 family";"G alpha (q) signalling events";"Interleukin receptor SHC signaling";"Regulation of signaling by CBL";"GPVI-mediated activation cascade";"RET signaling";"Rho GTPase cycle";"Interleukin-3, Interleukin-5 and GM-CSF signaling" lcl|NW_020311349.1_prot_XP_012251280.1_5249 5 Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-77595;Reactome: R-HSA-159231 "mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript" lcl|NW_020311970.1_prot_XP_012269076.1_15626 8 KEGG: 00950+1.14.16.2;MetaCyc: PWY-3581;KEGG: 00350+1.14.16.2;MetaCyc: PWY-5394;MetaCyc: PWY-5049;Reactome: R-HSA-209905;KEGG: 00790+1.14.16.2;MetaCyc: PWY-6133 "Isoquinoline alkaloid biosynthesis";"(S)-reticuline biosynthesis I";"Tyrosine metabolism";"Betalamic acid biosynthesis";"Rosmarinic acid biosynthesis II";"Catecholamine biosynthesis";"Folate biosynthesis";"(S)-reticuline biosynthesis II" lcl|NW_020311380.1_prot_XP_012268224.1_6756 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" lcl|NW_020311917.1_prot_XP_012250949.1_10228 7 KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" lcl|NW_020311943.1_prot_XP_012255252.1_11682 1 Reactome: R-HSA-6803204 "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" lcl|NW_020311327.1_prot_XP_012263476.1_3887 2 Reactome: R-HSA-8866423;Reactome: R-HSA-8963888 "VLDL assembly";"Chylomicron assembly" lcl|NW_020311991.1_prot_XP_012269736.1_20920 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" lcl|NW_020311974.1_prot_XP_012259911.1_16792 10 Reactome: R-HSA-1483166;KEGG: 00561+2.3.1.15;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-7411;KEGG: 00564+2.3.1.15;MetaCyc: PWY-8053;MetaCyc: PWY-8055 "Synthesis of PA";"Glycerolipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Glycerophospholipid metabolism";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis" lcl|NW_020311983.1_prot_XP_012255607.2_19712 1 Reactome: R-HSA-390651 "Dopamine receptors" lcl|NW_020311349.1_prot_XP_012251117.1_5267 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" lcl|NW_020311324.1_prot_XP_012269364.1_3568 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311410.1_prot_XP_025602003.1_7829 2 Reactome: R-HSA-444821;Reactome: R-HSA-418555 "Relaxin receptors";"G alpha (s) signalling events" lcl|NW_020311995.1_prot_XP_012257208.1_22014 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" lcl|NW_020311313.1_prot_XP_012261824.1_2925 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" lcl|NW_020311975.1_prot_XP_012253950.1_17073 1 Reactome: R-HSA-212300 "PRC2 methylates histones and DNA" lcl|NW_020311373.1_prot_XP_012266712.1_6444 5 KEGG: 00073+2.3.1.20;Reactome: R-HSA-1482883;Reactome: R-HSA-6798695;KEGG: 00561+2.3.1.20;Reactome: R-HSA-75109 "Cutin, suberine and wax biosynthesis";"Acyl chain remodeling of DAG and TAG";"Neutrophil degranulation";"Glycerolipid metabolism";"Triglyceride biosynthesis" lcl|NW_020311984.1_prot_XP_012254499.1_19949 2 Reactome: R-HSA-426486;Reactome: R-HSA-203927 "Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis" lcl|NW_020311954.1_prot_XP_020712068.1_12337 2 Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13 "RHO GTPases activate PKNs";"Phosphatidylinositol signaling system" lcl|NW_020311298.1_prot_XP_012250589.1_1224 3 Reactome: R-HSA-6807004;Reactome: R-HSA-6798695;Reactome: R-HSA-202427 "Negative regulation of MET activity";"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains" lcl|NW_020311304.1_prot_XP_012261120.1_1916 10 Reactome: R-HSA-5676590;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-5607761;Reactome: R-HSA-5684264;Reactome: R-HSA-2871837;Reactome: R-HSA-2565942;Reactome: R-HSA-202424 "NIK-->noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"Dectin-1 mediated noncanonical NF-kB signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"FCERI mediated NF-kB activation";"Regulation of PLK1 Activity at G2/M Transition";"Downstream TCR signaling" lcl|NW_020311985.1_prot_XP_012253907.1_20289 2 Reactome: R-HSA-2151201;Reactome: R-HSA-8964539 "Transcriptional activation of mitochondrial biogenesis";"Glutamate and glutamine metabolism" lcl|NW_020311292.1_prot_XP_012262803.1_709 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" lcl|NW_020311388.1_prot_XP_020710945.1_6971 18 MetaCyc: PWY-7117;KEGG: 00330+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-7115;MetaCyc: PWY-5913;KEGG: 00400+2.6.1.1;KEGG: 00710+2.6.1.1;MetaCyc: PWY-6642;KEGG: 00360+2.6.1.1;MetaCyc: PWY-7383;KEGG: 00250+2.6.1.1;MetaCyc: PWY-6638;KEGG: 00401+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00270+2.6.1.1 "C4 photosynthetic carbon assimilation cycle, PEPCK type";"Arginine and proline metabolism";"Coenzyme M biosynthesis II";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Partial TCA cycle (obligate autotrophs)";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Carbon fixation in photosynthetic organisms";"(R)-cysteate degradation";"Phenylalanine metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Alanine, aspartate and glutamate metabolism";"Sulfolactate degradation III";"Novobiocin biosynthesis";"Isoquinoline alkaloid biosynthesis";"Tyrosine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Arginine biosynthesis";"Cysteine and methionine metabolism" lcl|NW_020311982.1_prot_XP_020708730.1_19240 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311375.1_prot_XP_012256492.2_6558 1 Reactome: R-HSA-1296061 "HCN channels" lcl|NW_020311943.1_prot_XP_012255054.1_11572 4 Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568 "HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates" lcl|NW_020311962.1_prot_XP_012251969.1_13774 4 Reactome: R-HSA-4551295;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.131;KEGG: 00513+2.4.1.131 "Defective ALG11 causes ALG11-CDG (CDG-1p)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis" lcl|NW_020311343.1_prot_XP_020708742.1_4780 3 Reactome: R-HSA-983168;Reactome: R-HSA-6798695;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"Protein ubiquitination" lcl|NW_020311314.1_prot_XP_012252184.1_3073 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" lcl|NW_020311982.1_prot_XP_012258480.1_19186 13 Reactome: R-HSA-5674135;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6802955;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6802948;Reactome: R-HSA-9649948;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6802946;Reactome: R-HSA-6802952;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1 "MAP2K and MAPK activation";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Human papillomavirus infection";"Signaling by high-kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Signaling by moderate kinase activity BRAF mutants";"Signaling by BRAF and RAF fusions";"Relaxin signaling pathway";"Thermogenesis" lcl|NW_020311386.1_prot_XP_012268139.1_6924 7 MetaCyc: PWY-7805;MetaCyc: PWY-6605;MetaCyc: PWY-7807;Reactome: R-HSA-74217;Reactome: R-HSA-6798695;KEGG: 00230+2.4.2.7;MetaCyc: PWY-6610 "(aminomethyl)phosphonate degradation";"Adenine and adenosine salvage II";"Glyphosate degradation III";"Purine salvage";"Neutrophil degranulation";"Purine metabolism";"Adenine salvage" lcl|NW_020311983.1_prot_XP_012268347.1_19604 7 Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-5620922;Reactome: R-HSA-390471;Reactome: R-HSA-6798695;Reactome: R-HSA-390450;Reactome: R-HSA-389957 "Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"BBSome-mediated cargo-targeting to cilium";"Association of TriC/CCT with target proteins during biosynthesis";"Neutrophil degranulation";"Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC" lcl|NW_020311380.1_prot_XP_012268212.1_6714 8 Reactome: R-HSA-432720;Reactome: R-HSA-5099900;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-3928665;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-5140745 "Lysosome Vesicle Biogenesis";"WNT5A-dependent internalization of FZD4";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"Gap junction degradation";"Formation of annular gap junctions";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2" lcl|NW_020311966.1_prot_XP_020707005.1_14549 2 Reactome: R-HSA-70921;KEGG: 00340+2.1.1.22 "Histidine catabolism";"Histidine metabolism" lcl|NW_020311320.1_prot_XP_012268075.1_3393 4 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-76071 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" lcl|NW_020311329.1_prot_XP_025601731.1_3973 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" lcl|NW_020311977.1_prot_XP_025602761.1_17918 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" lcl|NW_020311436.1_prot_XP_012258115.2_8767 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311983.1_prot_XP_012255648.1_19789 1 Reactome: R-HSA-189200 "Cellular hexose transport" lcl|NW_020311401.1_prot_XP_020707828.1_7479 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" lcl|NW_020311436.1_prot_XP_012258216.1_8778 3 Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596 "Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I" lcl|NW_020311958.1_prot_XP_012255948.1_12919 13 Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339 "Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane" lcl|NW_020311462.1_prot_XP_012252263.1_9211 6 MetaCyc: PWY-6898;KEGG: 00730+2.7.6.2;Reactome: R-HSA-196819;MetaCyc: PWY-6908;MetaCyc: PWY-7356;MetaCyc: PWY-6907 "Thiamine salvage III";"Thiamine metabolism";"Vitamin B1 (thiamin) metabolism";"Thiamine diphosphate biosynthesis IV (eukaryotes)";"Thiamine salvage IV (yeast)";"Thiamine diphosphate biosynthesis III (Staphylococcus)" lcl|NW_020311401.1_prot_XP_012254894.1_7529 6 KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508;Reactome: R-HSA-1489509;Reactome: R-HSA-418597;Reactome: R-HSA-2029485;Reactome: R-HSA-1250196 "Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"DAG and IP3 signaling";"G alpha (z) signalling events";"Role of phospholipids in phagocytosis";"SHC1 events in ERBB2 signaling" lcl|NW_020311986.1_prot_XP_012258838.2_20352 1 Reactome: R-HSA-156588 "Glucuronidation" lcl|NW_020311943.1_prot_XP_012255180.1_11563 7 Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-606279;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025 "Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Deposition of new CENPA-containing nucleosomes at the centromere";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation" lcl|NW_020311305.1_prot_XP_012251422.1_2043 3 Reactome: R-HSA-8943724;Reactome: R-HSA-8939243;Reactome: R-HSA-2559580 "Regulation of PTEN gene transcription";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Oxidative Stress Induced Senescence" lcl|NW_020311312.1_prot_XP_012266916.1_2593 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" lcl|NW_020311983.1_prot_XP_020711802.1_19479 1 Reactome: R-HSA-8951664 "Neddylation" lcl|NW_020311964.1_prot_XP_012261683.1_13887 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" lcl|NW_020311961.1_prot_XP_012262697.1_13539 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" lcl|NW_020311993.1_prot_XP_012265160.1_21493 2 KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20 "Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis" lcl|NW_020311988.1_prot_XP_020709727.1_20697 3 Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081 "Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling" lcl|NW_020311976.1_prot_XP_012257705.1_17386 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" lcl|NW_020311475.1_prot_XP_020707124.1_9388 16 Reactome: R-HSA-388841;Reactome: R-HSA-1266695;Reactome: R-HSA-9009391;Reactome: R-HSA-512988;Reactome: R-HSA-912631;Reactome: R-HSA-114604;Reactome: R-HSA-912526;Reactome: R-HSA-194840;Reactome: R-HSA-8853659;Reactome: R-HSA-416476;Reactome: R-HSA-389357;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558;Reactome: R-HSA-1257604;Reactome: R-HSA-1660499;Reactome: R-HSA-1433557 "Costimulation by the CD28 family";"Interleukin-7 signaling";"Extra-nuclear estrogen signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of signaling by CBL";"GPVI-mediated activation cascade";"Interleukin receptor SHC signaling";"Rho GTPase cycle";"RET signaling";"G alpha (q) signalling events";"CD28 dependent PI3K/Akt signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"PIP3 activates AKT signaling";"Synthesis of PIPs at the plasma membrane";"Signaling by SCF-KIT"