Accession_ID Pathway_Count Pathway_IDs Pathway_Names XP_046743088.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046736447.1 3 Reactome: R-HSA-72165;Reactome: R-HSA-72163;Reactome: R-HSA-430039 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease" XP_046735184.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" XP_046750678.1 2 Reactome: R-HSA-163282;Reactome: R-HSA-2151201 "Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis" XP_046739755.1 4 Reactome: R-HSA-982772;Reactome: R-HSA-2586552;Reactome: R-HSA-983231;Reactome: R-HSA-1170546 "Growth hormone receptor signaling";"Signaling by Leptin";"Factors involved in megakaryocyte development and platelet production";"Prolactin receptor signaling" XP_046744189.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046745838.1 6 Reactome: R-HSA-1483166;Reactome: R-HSA-163560;MetaCyc: PWY-4261;KEGG: 00564+1.1.5.3;MetaCyc: PWY-6118;MetaCyc: PWY-6952 "Synthesis of PA";"Triglyceride catabolism";"Glycerol degradation I";"Glycerophospholipid metabolism";"Glycerol-3-phosphate shuttle";"Glycerophosphodiester degradation" XP_046745273.1 5 Reactome: R-HSA-936964;Reactome: R-HSA-937041;Reactome: R-HSA-166166;Reactome: R-HSA-168164;Reactome: R-HSA-937072 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1";"MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex" XP_046735753.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046735888.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046747133.1 9 Reactome: R-HSA-2173796;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167152;Reactome: R-HSA-6807505;Reactome: R-HSA-112382;Reactome: R-HSA-167290 "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA polymerase II transcribes snRNA genes";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation" XP_046742414.1 3 Reactome: R-HSA-194313;Reactome: R-HSA-114608;Reactome: R-HSA-195399 "VEGF ligand-receptor interactions";"Platelet degranulation";"VEGF binds to VEGFR leading to receptor dimerization" XP_046744097.1 14 Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7725;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-6598;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7035 "Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Sciadonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis" XP_046736159.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046745261.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046747799.1 1 Reactome: R-HSA-2995383 "Initiation of Nuclear Envelope Reformation" XP_046745987.1 1 Reactome: R-HSA-6807878 "COPI-mediated anterograde transport" XP_046736321.1 3 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046746277.1 7 Reactome: R-HSA-141444;Reactome: R-HSA-606279;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Deposition of new CENPA-containing nucleosomes at the centromere";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" XP_046735769.1 6 Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817 "Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046745275.1 5 Reactome: R-HSA-166166;Reactome: R-HSA-168164;Reactome: R-HSA-937072;Reactome: R-HSA-936964;Reactome: R-HSA-937041 "MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1" XP_046740160.1 2 Reactome: R-HSA-8866907;Reactome: R-HSA-8866904 "Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors" XP_046739578.1 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" XP_046744861.1 3 Reactome: R-HSA-3359471;Reactome: R-HSA-196741;KEGG: 00860+2.5.1.17 "Defective MMAB causes methylmalonic aciduria type cblB";"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Porphyrin and chlorophyll metabolism" XP_046746667.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046735682.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046742787.1 6 KEGG: 00930+3.1.1.17;KEGG: 00053+3.1.1.17;MetaCyc: PWY-2221;MetaCyc: PWY-5530;KEGG: 00030+3.1.1.17;MetaCyc: PWY-7165 "Caprolactam degradation";"Ascorbate and aldarate metabolism";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Sorbitol biosynthesis II";"Pentose phosphate pathway";"L-ascorbate biosynthesis VI (engineered pathway)" XP_046746027.1 3 MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1 "Diethylphosphate degradation";"Thiamine metabolism";"Folate biosynthesis" XP_046750587.1 1 Reactome: R-HSA-163560 "Triglyceride catabolism" XP_046741610.1 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" XP_046743587.1 7 Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;MetaCyc: PWY-7511;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus" XP_046743762.1 11 Reactome: R-HSA-432142;Reactome: R-HSA-114604;Reactome: R-HSA-512988;Reactome: R-HSA-9008059;Reactome: R-HSA-389948;Reactome: R-HSA-210990;Reactome: R-HSA-391160;Reactome: R-HSA-912694;Reactome: R-HSA-877312;Reactome: R-HSA-388841;Reactome: R-HSA-909733 "Platelet sensitization by LDL";"GPVI-mediated activation cascade";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Interleukin-37 signaling";"PD-1 signaling";"PECAM1 interactions";"Signal regulatory protein family interactions";"Regulation of IFNA signaling";"Regulation of IFNG signaling";"Costimulation by the CD28 family";"Interferon alpha/beta signaling" XP_046748478.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046753236.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046746983.1 13 MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-7222;MetaCyc: PWY-7227;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198;MetaCyc: PWY-6545;MetaCyc: PWY-7226;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7220;KEGG: 00480+1.17.4.1;KEGG: 00230+1.17.4.1 "Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Purine metabolism" XP_046742223.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046742879.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046751613.1 8 MetaCyc: PWY-7391;Reactome: R-HSA-191273;MetaCyc: PWY-922;MetaCyc: PWY-6174;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;KEGG: 00900+1.1.1.34;MetaCyc: PWY-7524 "Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis";"Mevalonate pathway I";"Mevalonate pathway II (archaea)";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"Terpenoid backbone biosynthesis";"Mevalonate pathway III (archaea)" XP_046742083.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046746959.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046752168.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046753020.1 13 Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-7883 "Keratan sulfate degradation";"Glycosphingolipid metabolism";"CS/DS degradation";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation";"Anhydromuropeptides recycling II" XP_046734332.1 4 Reactome: R-HSA-418594;Reactome: R-HSA-201681;Reactome: R-HSA-5689880;Reactome: R-HSA-4641257 "G alpha (i) signalling events";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"Degradation of AXIN" XP_046752235.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046753418.1 2 Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46 "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism" XP_046753200.1 4 MetaCyc: PWY-3722;Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-7494 "Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline catabolism";"Glycine, serine and threonine metabolism";"Choline degradation IV" XP_046750900.1 1 Reactome: R-HSA-3214815 "HDACs deacetylate histones" XP_046737419.1 9 KEGG: 00401+2.6.1.5;Reactome: R-HSA-8963684;KEGG: 00270+2.6.1.5;KEGG: 00350+2.6.1.5;KEGG: 00400+2.6.1.5;KEGG: 00130+2.6.1.5;KEGG: 00360+2.6.1.5;KEGG: 00960+2.6.1.5;KEGG: 00950+2.6.1.5 "Novobiocin biosynthesis";"Tyrosine catabolism";"Cysteine and methionine metabolism";"Tyrosine metabolism";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Phenylalanine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Isoquinoline alkaloid biosynthesis" XP_046733898.1 8 Reactome: R-HSA-5689880;Reactome: R-HSA-8948747;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-8866652;Reactome: R-HSA-6804757 "Ub-specific processing proteases";"Regulation of PTEN localization";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Regulation of TP53 Degradation" XP_046750181.1 1 Reactome: R-HSA-418886 "Netrin mediated repulsion signals" XP_046746516.1 3 MetaCyc: PWY-7892;MetaCyc: PWY-7887;Reactome: R-HSA-6787450 "Trna-uridine 2-thiolation and selenation (bacteria)";"Protein SAMPylation and SAMP-mediated thiolation";"tRNA modification in the mitochondrion" XP_046737487.1 6 Reactome: R-HSA-196819;MetaCyc: PWY-6898;MetaCyc: PWY-6907;MetaCyc: PWY-7356;MetaCyc: PWY-6908;KEGG: 00730+2.7.6.2 "Vitamin B1 (thiamin) metabolism";"Thiamine salvage III";"Thiamine diphosphate biosynthesis III (Staphylococcus)";"Thiamine salvage IV (yeast)";"Thiamine diphosphate biosynthesis IV (eukaryotes)";"Thiamine metabolism" XP_046753033.1 16 Reactome: R-HSA-1250347;Reactome: R-HSA-1250342;Reactome: R-HSA-8863795;Reactome: R-HSA-1250196;Reactome: R-HSA-9664565;Reactome: R-HSA-6811558;Reactome: R-HSA-1227986;Reactome: R-HSA-5673001;Reactome: R-HSA-2219530;Reactome: R-HSA-6785631;Reactome: R-HSA-1963640;Reactome: R-HSA-8847993;Reactome: R-HSA-1236394;Reactome: R-HSA-1251985;Reactome: R-HSA-1257604;Reactome: R-HSA-1963642 "SHC1 events in ERBB4 signaling";"PI3K events in ERBB4 signaling";"Downregulation of ERBB2 signaling";"SHC1 events in ERBB2 signaling";"Signaling by ERBB2 KD Mutants";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Signaling by ERBB2";"RAF/MAP kinase cascade";"Constitutive Signaling by Aberrant PI3K in Cancer";"ERBB2 Regulates Cell Motility";"GRB2 events in ERBB2 signaling";"ERBB2 Activates PTK6 Signaling";"Signaling by ERBB4";"Nuclear signaling by ERBB4";"PIP3 activates AKT signaling";"PI3K events in ERBB2 signaling" XP_046746809.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046751776.1 1 Reactome: R-HSA-391908 "Prostanoid ligand receptors" XP_046745982.1 1 Reactome: R-HSA-426486 "Small interfering RNA (siRNA) biogenesis" XP_046742197.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046743425.1 1 Reactome: R-HSA-425410 "Metal ion SLC transporters" XP_046752870.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046745713.1 2 MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1 "S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism" XP_046742063.1 2 Reactome: R-HSA-203927;Reactome: R-HSA-426486 "MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis" XP_046750381.1 7 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046739147.1 29 Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-3371453;Reactome: R-HSA-6804760;Reactome: R-HSA-2559586;KEGG: 04151+2.7.11.1;Reactome: R-HSA-69541;Reactome: R-HSA-69473;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693554;Reactome: R-HSA-6796648;Reactome: R-HSA-6803207;Reactome: R-HSA-5685938;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693571;Reactome: R-HSA-5693616;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-6804757;Reactome: R-HSA-5693548;Reactome: R-HSA-5693565;Reactome: R-HSA-5685942;Reactome: R-HSA-349425;Reactome: R-HSA-6803204 "Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Meiotic recombination";"Regulation of HSF1-mediated heat shock response";"Regulation of TP53 Activity through Methylation";"DNA Damage/Telomere Stress Induced Senescence";"PI3K-Akt signaling pathway";"Stabilization of p53";"G2/M DNA damage checkpoint";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"TP53 Regulates Transcription of DNA Repair Genes";"TP53 Regulates Transcription of Caspase Activators and Caspases";"HDR through Single Strand Annealing (SSA)";"mTOR signaling pathway";"Nonhomologous End-Joining (NHEJ)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Human immunodeficiency virus 1 infection";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Degradation";"Sensing of DNA Double Strand Breaks";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDR through Homologous Recombination (HRR)";"Autodegradation of the E3 ubiquitin ligase COP1";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" XP_046738339.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046751657.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046745815.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5689880 "UCH proteinases";"Ub-specific processing proteases" XP_046740258.1 9 KEGG: 04070+3.1.4.11;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351;MetaCyc: PWY-6367;MetaCyc: PWY-8052;Reactome: R-HSA-416476;Reactome: R-HSA-1855204;Reactome: R-HSA-112043 "Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"G alpha (q) signalling events";"Synthesis of IP3 and IP4 in the cytosol";"PLC beta mediated events" XP_046737510.1 1 Reactome: R-HSA-9022692 "Regulation of MECP2 expression and activity" XP_046745478.1 5 KEGG: 04660+3.1.3.16;Reactome: R-HSA-5687128;Reactome: R-HSA-176407;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"MAPK6/MAPK4 signaling";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046745670.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046747630.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-5357905 "RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling" XP_046743330.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046747825.1 1 Reactome: R-HSA-977443 "GABA receptor activation" XP_046752974.1 2 MetaCyc: PWY-7533;Reactome: R-HSA-1268020 "Gliotoxin biosynthesis";"Mitochondrial protein import" XP_046740256.1 14 Reactome: R-HSA-112043;Reactome: R-HSA-1855204;Reactome: R-HSA-416476;Reactome: R-HSA-4086398;MetaCyc: PWY-8052;Reactome: R-HSA-500657;MetaCyc: PWY-6367;MetaCyc: PWY-6351;MetaCyc: PWY-7039;Reactome: R-HSA-434316;Reactome: R-HSA-418217;Reactome: R-HSA-399997;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11 "PLC beta mediated events";"Synthesis of IP3 and IP4 in the cytosol";"G alpha (q) signalling events";"Ca2+ pathway";"2-arachidonoylglycerol biosynthesis";"Presynaptic function of Kainate receptors";"D-myo-inositol-5-phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G beta:gamma signalling through PLC beta";"Acetylcholine regulates insulin secretion";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system" XP_046750143.1 8 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-418889;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Caspase activation via Dependence Receptors in the absence of ligand";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046738789.1 26 Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-389977;Reactome: R-HSA-9648025;Reactome: R-HSA-389960;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-983189;Reactome: R-HSA-6807878;Reactome: R-HSA-8852276 "Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Post-chaperonin tubulin folding pathway";"EML4 and NUDC in mitotic spindle formation";"Formation of tubulin folding intermediates by CCT/TriC";"Cilium Assembly";"Separation of Sister Chromatids";"RHO GTPases activate IQGAPs";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Kinesins";"COPI-mediated anterograde transport";"The role of GTSE1 in G2/M progression after G2 checkpoint" XP_046741980.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046740744.1 8 Reactome: R-HSA-5173105;MetaCyc: PWY-7922;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;Reactome: R-HSA-5083629;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979 "O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)" XP_046745656.1 2 Reactome: R-HSA-975957;Reactome: R-HSA-9010553 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" XP_046742094.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046734476.1 1 Reactome: R-HSA-2151201 "Transcriptional activation of mitochondrial biogenesis" XP_046743000.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046749390.1 2 Reactome: R-HSA-389661;Reactome: R-HSA-2408508 "Glyoxylate metabolism and glycine degradation";"Metabolism of ingested SeMet, Sec, MeSec into H2Se" XP_046737339.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046743741.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046744101.1 9 MetaCyc: PWY-7385;MetaCyc: PWY-7902;MetaCyc: PWY-6118;KEGG: 00564+1.1.1.8;MetaCyc: PWY-5667;MetaCyc: PWY-5981;MetaCyc: PWY-7411;KEGG: 00564+1.1.1.94;Reactome: R-HSA-1483166 "1,3-propanediol biosynthesis (engineered)";"Glucosylglycerol biosynthesis";"Glycerol-3-phosphate shuttle";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Glycerophospholipid metabolism";"Synthesis of PA" XP_046744681.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046751076.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046734059.1 13 MetaCyc: PWY-7112;MetaCyc: PWY-7533;KEGG: 00982+2.5.1.18;MetaCyc: PWY-6842;MetaCyc: PWY-2261;KEGG: 00983+2.5.1.18;MetaCyc: PWY-4061;KEGG: 00980+2.5.1.18;KEGG: 00053+1.8.5.1;Reactome: R-HSA-156590;Reactome: R-HSA-196836;MetaCyc: PWY-6370;KEGG: 00480+2.5.1.18+1.8.5.1 "4-hydroxy-2-nonenal detoxification";"Gliotoxin biosynthesis";"Drug metabolism - cytochrome P450";"Glutathione-mediated detoxification II";"Ascorbate glutathione cycle";"Drug metabolism - other enzymes";"Glutathione-mediated detoxification I";"Metabolism of xenobiotics by cytochrome P450";"Ascorbate and aldarate metabolism";"Glutathione conjugation";"Vitamin C (ascorbate) metabolism";"Ascorbate recycling (cytosolic)";"Glutathione metabolism" XP_046749601.1 2 Reactome: R-HSA-72165;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" XP_046740908.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046738987.1 3 Reactome: R-HSA-9033241;Reactome: R-HSA-9603798;Reactome: R-HSA-8866654 "Peroxisomal protein import";"Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046739780.1 4 Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257;Reactome: R-HSA-2470946 "Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin" XP_046739216.1 1 Reactome: R-HSA-5601884 "PIWI-interacting RNA (piRNA) biogenesis" XP_046740119.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046747567.1 2 Reactome: R-HSA-73980;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation" XP_046745614.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046738088.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046738083.1 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" XP_046737730.1 6 MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;Reactome: R-HSA-9640463 "Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis" XP_046740614.1 5 KEGG: 00330+1.5.1.2;MetaCyc: PWY-3341;Reactome: R-HSA-8964539;MetaCyc: PWY-4981;MetaCyc: PWY-6344 "Arginine and proline metabolism";"L-proline biosynthesis III (from L-ornithine)";"Glutamate and glutamine metabolism";"L-proline biosynthesis II (from arginine)";"L-ornithine degradation II (Stickland reaction)" XP_046753973.1 9 Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-5617472;Reactome: R-HSA-400206;Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-381340;Reactome: R-HSA-400253 "Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of lipid metabolism by PPARalpha";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock" XP_046748638.1 1 Reactome: R-HSA-191859 "snRNP Assembly" XP_046737478.1 7 Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380259 "Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes" XP_046742880.1 3 Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-6807878 "Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"COPI-mediated anterograde transport" XP_046749575.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046748042.1 19 Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-3214858;Reactome: R-HSA-8876725;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-6790901 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"RMTs methylate histone arginines";"Protein methylation";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"rRNA modification in the nucleus and cytosol" XP_046739372.1 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046743864.1 24 Reactome: R-HSA-202040;Reactome: R-HSA-418594;Reactome: R-HSA-420092;Reactome: R-HSA-392851;Reactome: R-HSA-6814122;Reactome: R-HSA-392170;Reactome: R-HSA-428930;Reactome: R-HSA-4086398;Reactome: R-HSA-8964616;Reactome: R-HSA-500657;Reactome: R-HSA-418592;Reactome: R-HSA-8964315;Reactome: R-HSA-416482;Reactome: R-HSA-432040;Reactome: R-HSA-392451;Reactome: R-HSA-418217;Reactome: R-HSA-418597;Reactome: R-HSA-9009391;Reactome: R-HSA-416476;Reactome: R-HSA-381676;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-456926;Reactome: R-HSA-400042 "G-protein activation";"G alpha (i) signalling events";"Glucagon-type ligand receptors";"Prostacyclin signalling through prostacyclin receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"ADP signalling through P2Y purinoceptor 12";"Thromboxane signalling through TP receptor";"Ca2+ pathway";"G beta:gamma signalling through CDC42";"Presynaptic function of Kainate receptors";"ADP signalling through P2Y purinoceptor 1";"G beta:gamma signalling through BTK";"G alpha (12/13) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through PLC beta";"G alpha (z) signalling events";"Extra-nuclear estrogen signaling";"G alpha (q) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"Thrombin signalling through proteinase activated receptors (PARs)";"Adrenaline,noradrenaline inhibits insulin secretion" XP_046753953.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046748595.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046752887.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046739879.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046751667.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046746606.1 2 Reactome: R-HSA-6783310;Reactome: R-HSA-5693568 "Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates" XP_046745876.1 7 Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724 "Macroautophagy";"mTOR signalling";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription" XP_046739063.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046751662.1 3 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" XP_046734934.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046738879.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046752373.1 1 Reactome: R-HSA-163125 "Post-translational modification: synthesis of GPI-anchored proteins" XP_046743434.1 56 Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-1236974;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827 "Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"ER-Phagosome pathway";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"UCH proteinases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex" XP_046749563.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046736500.1 2 Reactome: R-HSA-5663220;Reactome: R-HSA-376176 "RHO GTPases Activate Formins";"Signaling by ROBO receptors" XP_046736752.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046753646.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046741699.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046742387.1 3 MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2 "Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism" XP_046740014.1 7 Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-429947;Reactome: R-HSA-72702;Reactome: R-HSA-166208;Reactome: R-HSA-72662 "GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Deadenylation of mRNA";"Ribosomal scanning and start codon recognition";"mTORC1-mediated signalling";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" XP_046740745.1 8 Reactome: R-HSA-5083629;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7922;Reactome: R-HSA-5173105;MetaCyc: PWY-7921;Reactome: R-HSA-5083633;KEGG: 00515+2.4.1.109 "Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"O-linked glycosylation";"Protein O-mannosylation I (yeast)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Mannose type O-glycan biosynthesis" XP_046741145.1 6 KEGG: 00500+2.4.1.18;KEGG: 00500+3.2.1.1;MetaCyc: PWY-7900;MetaCyc: PWY-622;Reactome: R-HSA-189085;MetaCyc: PWY-5067 "Starch and sucrose metabolism";"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch biosynthesis";"Digestion of dietary carbohydrate";"Glycogen biosynthesis II (from UDP-D-Glucose)" XP_046741038.1 5 Reactome: R-HSA-201722;Reactome: R-HSA-3214841;Reactome: R-HSA-5617472;Reactome: R-HSA-8936459;Reactome: R-HSA-3769402 "Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Deactivation of the beta-catenin transactivating complex" XP_046749885.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046745630.1 7 Reactome: R-HSA-2470946;Reactome: R-HSA-9018519;Reactome: R-HSA-1221632;Reactome: R-HSA-2500257;Reactome: R-HSA-3108214;Reactome: R-HSA-2468052;Reactome: R-HSA-2467813 "Cohesin Loading onto Chromatin";"Estrogen-dependent gene expression";"Meiotic synapsis";"Resolution of Sister Chromatid Cohesion";"SUMOylation of DNA damage response and repair proteins";"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids" XP_046740099.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046749561.1 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" XP_046745596.1 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" XP_046746315.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046738220.1 16 Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167287;Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-8951664;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-1234176;Reactome: R-HSA-180585;Reactome: R-HSA-983168;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-9010553;Reactome: R-HSA-167290 "RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Neddylation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Vif-mediated degradation of APOBEC3G";"Antigen processing: Ubiquitination & Proteasome degradation";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Regulation of expression of SLITs and ROBOs";"Pausing and recovery of HIV elongation" XP_046752464.1 12 Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-8854518;Reactome: R-HSA-381038;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270 "Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"AURKA Activation by TPX2";"XBP1(S) activates chaperone genes";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes" XP_046741095.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046736237.1 2 Reactome: R-HSA-1632852;Reactome: R-HSA-5689880 "Macroautophagy";"Ub-specific processing proteases" XP_046743481.1 3 Reactome: R-HSA-6785807;Reactome: R-HSA-8939902;Reactome: R-HSA-8878166 "Interleukin-4 and Interleukin-13 signaling";"Regulation of RUNX2 expression and activity";"Transcriptional regulation by RUNX2" XP_046750263.1 6 Reactome: R-HSA-4086398;Reactome: R-HSA-201722;Reactome: R-HSA-4411364;Reactome: R-HSA-4641265;Reactome: R-HSA-8951430;Reactome: R-HSA-3769402 "Ca2+ pathway";"Formation of the beta-catenin:TCF transactivating complex";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Repression of WNT target genes";"RUNX3 regulates WNT signaling";"Deactivation of the beta-catenin transactivating complex" XP_046744751.1 3 Reactome: R-HSA-349425;MetaCyc: PWY-7511;Reactome: R-HSA-8951664 "Autodegradation of the E3 ubiquitin ligase COP1";"Protein ubiquitination";"Neddylation" XP_046737754.1 7 Reactome: R-HSA-4641258;Reactome: R-HSA-4086400;Reactome: R-HSA-201688;Reactome: R-HSA-5663220;Reactome: R-HSA-5368598;Reactome: R-HSA-4641262;Reactome: R-HSA-201681 "Degradation of DVL";"PCP/CE pathway";"WNT mediated activation of DVL";"RHO GTPases Activate Formins";"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"TCF dependent signaling in response to WNT" XP_046753153.1 3 Reactome: R-HSA-5632968;Reactome: R-HSA-5632928;Reactome: R-HSA-5358565 "Defective Mismatch Repair Associated With MSH6";"Defective Mismatch Repair Associated With MSH2";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)" XP_046734627.1 31 MetaCyc: PWY-6799;MetaCyc: PWY-5973;MetaCyc: PWY-4381;MetaCyc: PWY-5367;MetaCyc: PWY-7388;MetaCyc: PWY-5966-1;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWYG-321;MetaCyc: PWY-5989;MetaCyc: PWY-6282;MetaCyc: PWY-8047;MetaCyc: PWY-5142;MetaCyc: PWY-6519;MetaCyc: PWY-6113;MetaCyc: PWY-7663;Reactome: R-HSA-75105;MetaCyc: PWY-5971;MetaCyc: PWY-7664;MetaCyc: PWY-7858;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-2426168;MetaCyc: PWY-5147;Reactome: R-HSA-163765;MetaCyc: PWY-5994;MetaCyc: PWY-7723;MetaCyc: PWY-5366;MetaCyc: PWY-7746;Reactome: R-HSA-199220;Reactome: R-HSA-9029558;MetaCyc: PWY-8012;MetaCyc: PWY-8049 "Fatty acid biosynthesis initiation (plant mitochondria)";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Petroselinate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis";"";"Stearate biosynthesis II (bacteria and plants)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Bryostatin biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"8-amino-7-oxononanoate biosynthesis I";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"Fatty acyl-CoA biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis IV (anaerobic)";"(5Z)-dodecenoate biosynthesis II";"Biotin metabolism";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis I (plants)";"ChREBP activates metabolic gene expression";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Bacterial bioluminescence";"Palmitoleate biosynthesis II (plants and bacteria)";"Mycobacterial sulfolipid biosynthesis";"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Mupirocin biosynthesis";"Pederin biosynthesis" XP_046745234.1 2 Reactome: R-HSA-1482798;Reactome: R-HSA-1268020 "Acyl chain remodeling of CL";"Mitochondrial protein import" XP_046749066.1 4 MetaCyc: PWY-6482;Reactome: R-HSA-8849175;MetaCyc: PWY-7546;Reactome: R-HSA-5358493 "Diphthamide biosynthesis I (archaea)";"Threonine catabolism";"Diphthamide biosynthesis II (eukaryotes)";"Synthesis of diphthamide-EEF2" XP_046745508.1 3 Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066 "RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" XP_046738448.1 4 Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823 "Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex" XP_046735475.1 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" XP_046748088.1 4 MetaCyc: PWY-7394;MetaCyc: PWY-5691;MetaCyc: PWY-7849;KEGG: 00230+4.1.1.97 "Urate conversion to allantoin II";"Urate conversion to allantoin I";"Urate conversion to allantoin III";"Purine metabolism" XP_046751242.1 1 Reactome: R-HSA-390648 "Muscarinic acetylcholine receptors" XP_046737604.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046747332.1 7 Reactome: R-HSA-2142691;Reactome: R-HSA-9023661;Reactome: R-HSA-9018896;Reactome: R-HSA-9020265;Reactome: R-HSA-9018681;Reactome: R-HSA-6798695;Reactome: R-HSA-9018676 "Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Biosynthesis of E-series 18(R)-resolvins";"Biosynthesis of E-series 18(S)-resolvins";"Biosynthesis of aspirin-triggered D-series resolvins";"Biosynthesis of protectins";"Neutrophil degranulation";"Biosynthesis of D-series resolvins" XP_046739825.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046742556.1 12 Reactome: R-HSA-166208;Reactome: R-HSA-72662;Reactome: R-HSA-1169408;Reactome: R-HSA-450408;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-429947;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-72706 "mTORC1-mediated signalling";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"ISG15 antiviral mechanism";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Deadenylation of mRNA";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046741698.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046751965.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046754007.1 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" XP_046752970.1 6 Reactome: R-HSA-429958;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-6791226 "mRNA decay by 3' to 5' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046746970.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046737987.1 9 Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-69205;Reactome: R-HSA-68616;Reactome: R-HSA-68867;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68962;Reactome: R-HSA-68689 "Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"G1/S-Specific Transcription";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Activation of the pre-replicative complex";"CDC6 association with the ORC:origin complex" XP_046741645.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046737654.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046752874.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" XP_046746681.1 7 KEGG: 00710+3.1.3.11;KEGG: 00051+3.1.3.11;KEGG: 00030+3.1.3.11;Reactome: R-HSA-70263;KEGG: 00010+3.1.3.11;MetaCyc: PWY-5484;KEGG: 00680+3.1.3.11 "Carbon fixation in photosynthetic organisms";"Fructose and mannose metabolism";"Pentose phosphate pathway";"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism" XP_046752211.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046749572.1 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" XP_046745936.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046747753.1 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" XP_046749981.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046734318.1 16 Reactome: R-HSA-8934593;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700;Reactome: R-HSA-8943723;Reactome: R-HSA-9018519;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-8936459;Reactome: R-HSA-8853884;Reactome: R-HSA-4086398;Reactome: R-HSA-2559585;Reactome: R-HSA-5687128;Reactome: R-HSA-426496 "Regulation of RUNX1 Expression and Activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of PTEN mRNA translation";"Estrogen-dependent gene expression";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by VENTX";"Ca2+ pathway";"Oncogene Induced Senescence";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs" XP_046750259.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046751994.1 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" XP_046752463.1 3 MetaCyc: PWY-6619;Reactome: R-HSA-74217;KEGG: 00230+2.7.1.20 "Adenine and adenosine salvage VI";"Purine salvage";"Purine metabolism" XP_046752890.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046739541.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046746780.1 29 Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-6781827;Reactome: R-HSA-73762;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-427413;Reactome: R-HSA-73772;Reactome: R-HSA-112382;Reactome: R-HSA-167162;Reactome: R-HSA-167158;Reactome: R-HSA-6782135;Reactome: R-HSA-76042;Reactome: R-HSA-167246;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-72086;Reactome: R-HSA-167161;Reactome: R-HSA-6782210;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-113418;Reactome: R-HSA-5696400;Reactome: R-HSA-73863 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"Formation of RNA Pol II elongation complex";"RNA Polymerase II HIV Promoter Escape";"Formation of the HIV-1 Early Elongation Complex";"Dual incision in TC-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Tat-mediated elongation of the HIV-1 transcript";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"mRNA Capping";"HIV Transcription Initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the Early Elongation Complex";"Dual Incision in GG-NER";"RNA Polymerase I Transcription Termination" XP_046739211.1 6 MetaCyc: PWY-6174;MetaCyc: PWY-7391;KEGG: 00900+2.7.1.36;Reactome: R-HSA-191273;Reactome: R-HSA-2426168;MetaCyc: PWY-922 "Mevalonate pathway II (archaea)";"Isoprene biosynthesis II (engineered)";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Mevalonate pathway I" XP_046741972.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046736184.1 8 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-2028269 "Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Signaling by Hippo" XP_046747773.1 26 Reactome: R-HSA-110312;Reactome: R-HSA-110314;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-6804114;Reactome: R-HSA-5685942;Reactome: R-HSA-69166;Reactome: R-HSA-6782135;Reactome: R-HSA-5656121;Reactome: R-HSA-5358565;Reactome: R-HSA-5656169;Reactome: R-HSA-174417;Reactome: R-HSA-5655862;Reactome: R-HSA-8866654;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-110320;Reactome: R-HSA-174414;Reactome: R-HSA-69183;Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-5696397;Reactome: R-HSA-6782210;Reactome: R-HSA-5358606;Reactome: R-HSA-174437;Reactome: R-HSA-4615885 "Translesion synthesis by REV1";"Recognition of DNA damage by PCNA-containing replication complex";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate";"Dual incision in TC-NER";"Translesion synthesis by POLI";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Termination of translesion DNA synthesis";"Telomere C-strand (Lagging Strand) Synthesis";"Translesion synthesis by POLK";"E3 ubiquitin ligases ubiquitinate target proteins";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Translesion Synthesis by POLH";"Processive synthesis on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Dual Incision in GG-NER";"Polymerase switching";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Removal of the Flap Intermediate from the C-strand";"SUMOylation of DNA replication proteins" XP_046739827.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046748219.1 6 MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817 "Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046752312.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046747319.1 26 Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-389977;Reactome: R-HSA-9648025;Reactome: R-HSA-389960;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-983189;Reactome: R-HSA-6807878;Reactome: R-HSA-8852276 "Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Post-chaperonin tubulin folding pathway";"EML4 and NUDC in mitotic spindle formation";"Formation of tubulin folding intermediates by CCT/TriC";"Separation of Sister Chromatids";"Cilium Assembly";"HCMV Early Events";"RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Kinesins";"COPI-mediated anterograde transport";"The role of GTSE1 in G2/M progression after G2 checkpoint" XP_046743553.1 2 Reactome: R-HSA-1268020;Reactome: R-HSA-8869496 "Mitochondrial protein import";"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" XP_046741192.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046739837.1 4 Reactome: R-HSA-5250958;Reactome: R-HSA-6794361;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Toxicity of botulinum toxin type B (BoNT/B)";"Neurexins and neuroligins";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046740315.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046739336.1 7 Reactome: R-HSA-1483226;MetaCyc: PWY-7625;MetaCyc: PWY-6352;KEGG: 00564+2.7.8.11;KEGG: 04070+2.7.8.11;MetaCyc: PWY-6351;KEGG: 00562+2.7.8.11 "Synthesis of PI";"Phosphatidylinositol biosynthesis II (eukaryotes)";"3-phosphoinositide biosynthesis";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism" XP_046752493.1 29 Reactome: R-HSA-113418;Reactome: R-HSA-5696400;Reactome: R-HSA-73863;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-6782210;Reactome: R-HSA-167161;Reactome: R-HSA-72086;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-73772;Reactome: R-HSA-167162;Reactome: R-HSA-112382;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-76042;Reactome: R-HSA-5696395;Reactome: R-HSA-167246;Reactome: R-HSA-6781823;Reactome: R-HSA-73779;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-73762;Reactome: R-HSA-427413;Reactome: R-HSA-674695;Reactome: R-HSA-6796648 "Formation of the Early Elongation Complex";"Dual Incision in GG-NER";"RNA Polymerase I Transcription Termination";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HIV Transcription Initiation";"mRNA Capping";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"RNA Polymerase I Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"Formation of RNA Pol II elongation complex";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of Incision Complex in GG-NER";"Tat-mediated elongation of the HIV-1 transcript";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Initiation";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes" XP_046736528.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046741616.1 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" XP_046751595.1 1 Reactome: R-HSA-429958 "mRNA decay by 3' to 5' exoribonuclease" XP_046738130.1 2 Reactome: R-HSA-202733;Reactome: R-HSA-416993 "Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors" XP_046736581.1 2 Reactome: R-HSA-352230;Reactome: R-HSA-442660 "Amino acid transport across the plasma membrane";"Na+/Cl- dependent neurotransmitter transporters" XP_046753397.1 19 Reactome: R-HSA-438066;Reactome: R-HSA-9649948;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-5673000;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5576892;Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-6802955;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-9022692;Reactome: R-HSA-6802946;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-9620244;Reactome: R-HSA-111932 "Unblocking of NMDA receptors, glutamate binding and activation";"Signaling downstream of RAS mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"RAF activation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"Phase 0 - rapid depolarisation";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Regulation of MECP2 expression and activity";"Signaling by moderate kinase activity BRAF mutants";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB" XP_046741396.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656 "Wax biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis" XP_046736340.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046748689.1 14 KEGG: 00290+2.6.1.42;KEGG: 00770+2.6.1.42;MetaCyc: PWY-5076;KEGG: 00280+2.6.1.42;MetaCyc: PWY-5103;MetaCyc: PWY-5101;MetaCyc: PWY-5057;Reactome: R-HSA-70895;KEGG: 00966+2.6.1.42;KEGG: 00270+2.6.1.42;MetaCyc: PWY-7767;MetaCyc: PWY-5078;MetaCyc: PWY-5108;MetaCyc: PWY-5104 "Valine, leucine and isoleucine biosynthesis";"Pantothenate and CoA biosynthesis";"L-leucine degradation III";"Valine, leucine and isoleucine degradation";"L-isoleucine biosynthesis III";"L-isoleucine biosynthesis II";"L-valine degradation II";"Branched-chain amino acid catabolism";"Glucosinolate biosynthesis";"Cysteine and methionine metabolism";"L-leucine degradation IV (Stickland reaction)";"L-isoleucine degradation II";"L-isoleucine biosynthesis V";"L-isoleucine biosynthesis IV" XP_046735561.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046734716.1 2 Reactome: R-HSA-983168;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation" XP_046737994.1 2 Reactome: R-HSA-375281;Reactome: R-HSA-418555 "Hormone ligand-binding receptors";"G alpha (s) signalling events" XP_046739926.1 7 KEGG: 04070+3.1.3.25;Reactome: R-HSA-1855183;MetaCyc: PWY-2301;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.25;KEGG: 00521+3.1.3.25;MetaCyc: PWY-4702 "Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism";"Streptomycin biosynthesis";"Phytate degradation I" XP_046738685.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046753966.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046741860.1 11 Reactome: R-HSA-3214847;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-5689880;Reactome: R-HSA-73779;Reactome: R-HSA-167172 "HATs acetylate histones";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Ub-specific processing proteases";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome" XP_046735085.1 5 Reactome: R-HSA-6807878;Reactome: R-HSA-204005;Reactome: R-HSA-6811434;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"COPII-mediated vesicle transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" XP_046745894.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046744493.1 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" XP_046747458.1 1 Reactome: R-HSA-111465 "Apoptotic cleavage of cellular proteins" XP_046735337.1 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046751848.1 6 Reactome: R-HSA-8951664;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-8936459;Reactome: R-HSA-3769402 "Neddylation";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Deactivation of the beta-catenin transactivating complex" XP_046746369.1 8 Reactome: R-HSA-6798695;Reactome: R-HSA-9627069;Reactome: R-HSA-6803207;Reactome: R-HSA-111464;Reactome: R-HSA-8953750;Reactome: R-HSA-111463;Reactome: R-HSA-111459;Reactome: R-HSA-111458 "Neutrophil degranulation";"Regulation of the apoptosome activity";"TP53 Regulates Transcription of Caspase Activators and Caspases";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Transcriptional Regulation by E2F6";"SMAC (DIABLO) binds to IAPs";"Activation of caspases through apoptosome-mediated cleavage";"Formation of apoptosome" XP_046735524.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046752563.1 2 MetaCyc: PWY-7799;MetaCyc: PWY-7802 "Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)" XP_046749287.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046736201.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046747570.1 2 Reactome: R-HSA-749476;Reactome: R-HSA-73980 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination" XP_046738141.1 1 Reactome: R-HSA-201451 "Signaling by BMP" XP_046733761.1 14 MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-7601;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-5972 "Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)" XP_046743203.1 8 Reactome: R-HSA-6798695;Reactome: R-HSA-165159;Reactome: R-HSA-8943724;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-9639288 "Neutrophil degranulation";"mTOR signalling";"Regulation of PTEN gene transcription";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Macroautophagy";"Amino acids regulate mTORC1" XP_046751801.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-400253 "Transcriptional activation of mitochondrial biogenesis";"Circadian Clock" XP_046740440.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046742903.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046736461.1 25 Reactome: R-HSA-8936459;Reactome: R-HSA-8949275;Reactome: R-HSA-8951936;Reactome: R-HSA-8941284;Reactome: R-HSA-8941858;Reactome: R-HSA-8877330;Reactome: R-HSA-8939256;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-8939246;Reactome: R-HSA-8939245;Reactome: R-HSA-8940973;Reactome: R-HSA-8939247;Reactome: R-HSA-8941333;Reactome: R-HSA-8931987;Reactome: R-HSA-8939902;Reactome: R-HSA-8934593;Reactome: R-HSA-8939242;Reactome: R-HSA-8941332;Reactome: R-HSA-9018519;Reactome: R-HSA-8935964;Reactome: R-HSA-8941326;Reactome: R-HSA-8939243;Reactome: R-HSA-8878166;Reactome: R-HSA-8951911 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX3 regulates p14-ARF";"RUNX2 regulates chondrocyte maturation";"Regulation of RUNX3 expression and activity";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX1 regulates transcription of genes involved in WNT signaling";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates estrogen receptor mediated transcription";"Regulation of RUNX2 expression and activity";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX2 regulates genes involved in cell migration";"Estrogen-dependent gene expression";"RUNX1 regulates expression of components of tight junctions";"RUNX2 regulates bone development";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Transcriptional regulation by RUNX2";"RUNX3 regulates RUNX1-mediated transcription" XP_046748674.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046750227.1 24 Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-2730905;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5625740;Reactome: R-HSA-114604;Reactome: R-HSA-1257604;Reactome: R-HSA-444257;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5218921;Reactome: R-HSA-9634635;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5607764;Reactome: R-HSA-389357;Reactome: R-HSA-6804757;Reactome: R-HSA-392451;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-354192;Reactome: R-HSA-165158;Reactome: R-HSA-2871837;Reactome: R-HSA-202424 "Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"Role of LAT2/NTAL/LAB on calcium mobilization";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"RHO GTPases activate PKNs";"GPVI-mediated activation cascade";"PIP3 activates AKT signaling";"RSK activation";"mTOR signaling pathway";"VEGFR2 mediated cell proliferation";"Estrogen-stimulated signaling through PRKCZ";"Human immunodeficiency virus 1 infection";"CLEC7A (Dectin-1) signaling";"CD28 dependent PI3K/Akt signaling";"Regulation of TP53 Degradation";"G beta:gamma signalling through PI3Kgamma";"Relaxin signaling pathway";"Human papillomavirus infection";"Integrin signaling";"Activation of AKT2";"FCERI mediated NF-kB activation";"Downstream TCR signaling" XP_046736577.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046751297.1 40 Reactome: R-HSA-77075;Reactome: R-HSA-5617472;Reactome: R-HSA-5578749;Reactome: R-HSA-6807505;Reactome: R-HSA-73779;Reactome: R-HSA-203927;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-5601884;Reactome: R-HSA-167246;Reactome: R-HSA-167238;Reactome: R-HSA-72163;Reactome: R-HSA-168325;Reactome: R-HSA-72086;Reactome: R-HSA-167287;Reactome: R-HSA-167161;Reactome: R-HSA-72165;Reactome: R-HSA-113418;Reactome: R-HSA-8851708;Reactome: R-HSA-9018519;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-6796648;Reactome: R-HSA-75953;Reactome: R-HSA-112382;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-6782135;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-72203;Reactome: R-HSA-6782210 "RNA Pol II CTD phosphorylation and interaction with CE";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Transcriptional regulation by small RNAs";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"MicroRNA (miRNA) biogenesis";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"PIWI-interacting RNA (piRNA) biogenesis";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Major Pathway";"Viral Messenger RNA Synthesis";"mRNA Capping";"HIV elongation arrest and recovery";"HIV Transcription Initiation";"mRNA Splicing - Minor Pathway";"Formation of the Early Elongation Complex";"Signaling by FGFR2 IIIa TM";"Estrogen-dependent gene expression";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Initiation";"Formation of RNA Pol II elongation complex";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"Dual incision in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Processing of Capped Intron-Containing Pre-mRNA";"Gap-filling DNA repair synthesis and ligation in TC-NER" XP_046736773.1 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" XP_046739739.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046753731.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046736104.1 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" XP_046743798.1 14 Reactome: R-HSA-1474228;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700;Reactome: R-HSA-977225;Reactome: R-HSA-193692;Reactome: R-HSA-6798695;Reactome: R-HSA-9017802;Reactome: R-HSA-2122948;Reactome: R-HSA-205043;Reactome: R-HSA-2894862;Reactome: R-HSA-3928665;Reactome: R-HSA-2979096;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507 "Degradation of the extracellular matrix";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Amyloid fiber formation";"Regulated proteolysis of p75NTR";"Neutrophil degranulation";"Noncanonical activation of NOTCH3";"Activated NOTCH1 Transmits Signal to the Nucleus";"NRIF signals cell death from the nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"EPH-ephrin mediated repulsion of cells";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus" XP_046752120.1 1 Reactome: R-HSA-72165 "mRNA Splicing - Minor Pathway" XP_046743464.1 13 Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination" XP_046752382.1 3 Reactome: R-HSA-3899300;Reactome: R-HSA-3232118;Reactome: R-HSA-4090294 "SUMOylation of transcription cofactors";"SUMOylation of transcription factors";"SUMOylation of intracellular receptors" XP_046748155.1 4 Reactome: R-HSA-9018519;Reactome: R-HSA-3371568;Reactome: R-HSA-8939211;Reactome: R-HSA-3371497 "Estrogen-dependent gene expression";"Attenuation phase";"ESR-mediated signaling";"HSP90 chaperone cycle for steroid hormone receptors (SHR)" XP_046742517.1 6 Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-416993;Reactome: R-HSA-204005;Reactome: R-HSA-6807878;Reactome: R-HSA-6811434 "Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"Trafficking of GluR2-containing AMPA receptors";"COPII-mediated vesicle transport";"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046743311.1 5 Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-917977 "Insulin receptor recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Ion channel transport";"Transferrin endocytosis and recycling" XP_046747240.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046737030.1 13 Reactome: R-HSA-5140745;Reactome: R-HSA-167590;Reactome: R-HSA-8964038;Reactome: R-HSA-416993;Reactome: R-HSA-437239;Reactome: R-HSA-177504;Reactome: R-HSA-8866427;Reactome: R-HSA-8856825;Reactome: R-HSA-2132295;Reactome: R-HSA-3928665;Reactome: R-HSA-182218;Reactome: R-HSA-8856828;Reactome: R-HSA-5099900 "WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Nef Mediated CD4 Down-regulation";"LDL clearance";"Trafficking of GluR2-containing AMPA receptors";"Recycling pathway of L1";"Retrograde neurotrophin signalling";"VLDLR internalisation and degradation";"Cargo recognition for clathrin-mediated endocytosis";"MHC class II antigen presentation";"EPH-ephrin mediated repulsion of cells";"Nef Mediated CD8 Down-regulation";"Clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD4" XP_046747028.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046743626.1 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" XP_046745374.1 11 Reactome: R-HSA-6804114;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-3214858;Reactome: R-HSA-1368108;Reactome: R-HSA-1368082;Reactome: R-HSA-2151201;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-400206;Reactome: R-HSA-2426168 "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"RMTs methylate histone arginines";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"RORA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"Estrogen-dependent gene expression";"PPARA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"Activation of gene expression by SREBF (SREBP)" XP_046753357.1 5 KEGG: 04150+2.7.11.24;Reactome: R-HSA-376172;Reactome: R-HSA-168638;Reactome: R-HSA-4420097;Reactome: R-HSA-171007 "mTOR signaling pathway";"DSCAM interactions";"NOD1/2 Signaling Pathway";"VEGFA-VEGFR2 Pathway";"p38MAPK events" XP_046751615.1 6 Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.36;Reactome: R-HSA-1855204;KEGG: 04070+3.1.3.36;Reactome: R-HSA-194840;MetaCyc: PWY-6368 "Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"Rho GTPase cycle";"3-phosphoinositide degradation" XP_046737373.1 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" XP_046737421.1 13 Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-3000171;Reactome: R-HSA-186797;Reactome: R-HSA-2243919;Reactome: R-HSA-3000178;Reactome: R-HSA-3000157;Reactome: R-HSA-1650814;Reactome: R-HSA-2214320;Reactome: R-HSA-419037;Reactome: R-HSA-216083;Reactome: R-HSA-2022090;Reactome: R-HSA-1474244 "Collagen chain trimerization";"Collagen degradation";"Non-integrin membrane-ECM interactions";"Signaling by PDGF";"Crosslinking of collagen fibrils";"ECM proteoglycans";"Laminin interactions";"Collagen biosynthesis and modifying enzymes";"Anchoring fibril formation";"NCAM1 interactions";"Integrin cell surface interactions";"Assembly of collagen fibrils and other multimeric structures";"Extracellular matrix organization" XP_046747425.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046738370.1 2 Reactome: R-HSA-5578998;Reactome: R-HSA-174403 "Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)";"Glutathione synthesis and recycling" XP_046736462.1 25 Reactome: R-HSA-8941332;Reactome: R-HSA-9018519;Reactome: R-HSA-8941326;Reactome: R-HSA-8935964;Reactome: R-HSA-8939243;Reactome: R-HSA-8878166;Reactome: R-HSA-8951911;Reactome: R-HSA-8931987;Reactome: R-HSA-8939902;Reactome: R-HSA-8934593;Reactome: R-HSA-8939242;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-8939246;Reactome: R-HSA-8939247;Reactome: R-HSA-8940973;Reactome: R-HSA-8939245;Reactome: R-HSA-8941333;Reactome: R-HSA-8936459;Reactome: R-HSA-8949275;Reactome: R-HSA-8941284;Reactome: R-HSA-8951936;Reactome: R-HSA-8941858;Reactome: R-HSA-8877330;Reactome: R-HSA-8939256 "RUNX2 regulates genes involved in cell migration";"Estrogen-dependent gene expression";"RUNX2 regulates bone development";"RUNX1 regulates expression of components of tight junctions";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Transcriptional regulation by RUNX2";"RUNX3 regulates RUNX1-mediated transcription";"RUNX1 regulates estrogen receptor mediated transcription";"Regulation of RUNX2 expression and activity";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX2 regulates chondrocyte maturation";"RUNX3 regulates p14-ARF";"Regulation of RUNX3 expression and activity";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX1 regulates transcription of genes involved in WNT signaling" XP_046736681.1 6 Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68962 "Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Orc1 removal from chromatin";"Activation of the pre-replicative complex" XP_046745410.1 3 Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648 "Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK" XP_046739319.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046735638.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046741870.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046736142.1 4 Reactome: R-HSA-167160;Reactome: R-HSA-77075;MetaCyc: PWY-7375;Reactome: R-HSA-72086 "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE";"Mrna capping I";"mRNA Capping" XP_046740366.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" XP_046752286.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046753017.1 13 MetaCyc: PWY-7822;MetaCyc: PWY-7883;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-6902;Reactome: R-HSA-1660662;Reactome: R-HSA-2022857;Reactome: R-HSA-2024101;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00511+3.2.1.52 "Chitin degradation III (Serratia)";"Anhydromuropeptides recycling II";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation";"Chitin degradation II (Vibrio)";"Glycosphingolipid metabolism";"Keratan sulfate degradation";"CS/DS degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Other glycan degradation" XP_046742809.1 1 Reactome: R-HSA-525793 "Myogenesis" XP_046750254.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046744593.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046753337.1 1 Reactome: R-HSA-6811436 "COPI-independent Golgi-to-ER retrograde traffic" XP_046742852.1 7 Reactome: R-HSA-983231;Reactome: R-HSA-5625886;Reactome: R-HSA-3214842;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-9018519;Reactome: R-HSA-9029569 "Factors involved in megakaryocyte development and platelet production";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"HDMs demethylate histones";"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"Estrogen-dependent gene expression";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" XP_046752047.1 5 Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-983712 "Insulin receptor recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Ion channel transport" XP_046752901.1 2 Reactome: R-HSA-162588;Reactome: R-HSA-917729 "Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)" XP_046741158.1 1 Reactome: R-HSA-5656169 "Termination of translesion DNA synthesis" XP_046742561.1 12 Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72662;Reactome: R-HSA-166208;Reactome: R-HSA-1169408;Reactome: R-HSA-450408;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-429947 "L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"mTORC1-mediated signalling";"ISG15 antiviral mechanism";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Deadenylation of mRNA" XP_046739558.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-983168 "Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046750921.1 3 Reactome: R-HSA-74217;MetaCyc: PWY-6596;KEGG: 00230+3.5.4.6 "Purine salvage";"Adenosine nucleotides degradation I";"Purine metabolism" XP_046746025.1 3 MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1 "Diethylphosphate degradation";"Thiamine metabolism";"Folate biosynthesis" XP_046753530.1 2 Reactome: R-HSA-917729;Reactome: R-HSA-9610379 "Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events" XP_046734487.1 4 KEGG: 00510+2.4.1.259+2.4.1.261;KEGG: 00513+2.4.1.261;Reactome: R-HSA-4720454;Reactome: R-HSA-446193 "N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Defective ALG9 causes ALG9-CDG (CDG-1l)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" XP_046753951.1 4 KEGG: 00514+2.4.1.255;Reactome: R-HSA-5689603;Reactome: R-HSA-3214847;MetaCyc: PWY-7437 "Other types of O-glycan biosynthesis";"UCH proteinases";"HATs acetylate histones";"Protein O-[N-acetyl]-glucosylation" XP_046751027.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046741018.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046748282.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046737038.1 16 Reactome: R-HSA-176408;Reactome: R-HSA-174184;Reactome: R-HSA-176409;Reactome: R-HSA-174048;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-176412;Reactome: R-HSA-141430;Reactome: R-HSA-8853884;Reactome: R-HSA-179409;Reactome: R-HSA-174084;Reactome: R-HSA-176407;Reactome: R-HSA-174154;Reactome: R-HSA-2467813 "Regulation of APC/C activators between G1/S and early anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of mitotic proteins";"APC/C:Cdc20 mediated degradation of Cyclin B";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Phosphorylation of the APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Transcriptional Regulation by VENTX";"APC-Cdc20 mediated degradation of Nek2A";"Autodegradation of Cdh1 by Cdh1:APC/C";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids" XP_046752702.1 1 Reactome: R-HSA-418886 "Netrin mediated repulsion signals" XP_046734732.1 1 Reactome: R-HSA-8866654 "E3 ubiquitin ligases ubiquitinate target proteins" XP_046735303.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046742959.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046737981.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046740310.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046752919.1 2 Reactome: R-HSA-1433559;Reactome: R-HSA-8951664 "Regulation of KIT signaling";"Neddylation" XP_046749544.1 2 Reactome: R-HSA-5696394;Reactome: R-HSA-5689603 "DNA Damage Recognition in GG-NER";"UCH proteinases" XP_046739523.1 3 Reactome: R-HSA-264870;Reactome: R-HSA-6794361;Reactome: R-HSA-6798695 "Caspase-mediated cleavage of cytoskeletal proteins";"Neurexins and neuroligins";"Neutrophil degranulation" XP_046748567.1 3 KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154;Reactome: R-HSA-445355 "Purine metabolism";"Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction" XP_046753240.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046739027.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046742064.1 2 Reactome: R-HSA-203927;Reactome: R-HSA-426486 "MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis" XP_046743187.1 16 Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-156902 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation" XP_046733767.1 14 MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598 "Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis" XP_046747712.1 3 Reactome: R-HSA-202427;Reactome: R-HSA-6807004;Reactome: R-HSA-6798695 "Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity";"Neutrophil degranulation" XP_046753857.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046749299.1 5 Reactome: R-HSA-8875360;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-182971;Reactome: R-HSA-6807004 "InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"EGFR downregulation";"Negative regulation of MET activity" XP_046735768.1 5 Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-427413;Reactome: R-HSA-73863;Reactome: R-HSA-73772 "B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape" XP_046749173.1 18 Reactome: R-HSA-156902;Reactome: R-HSA-6790901;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-166208;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553 "Peptide chain elongation";"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"mTORC1-mediated signalling";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" XP_046752217.1 2 Reactome: R-HSA-3238698;Reactome: R-HSA-373080 "WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)" XP_046747046.1 1 Reactome: R-HSA-400253 "Circadian Clock" XP_046735980.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046737140.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046743644.1 3 MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167 "Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol" XP_046737286.1 7 Reactome: R-HSA-2122948;MetaCyc: PWY-7511;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096 "Activated NOTCH1 Transmits Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus" XP_046740450.1 2 Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13 "Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system" XP_046750209.1 10 Reactome: R-HSA-5607761;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5684264;Reactome: R-HSA-2565942;Reactome: R-HSA-5676590 "Dectin-1 mediated noncanonical NF-kB signaling";"CLEC7A (Dectin-1) signaling";"Neddylation";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Regulation of PLK1 Activity at G2/M Transition";"NIK-->noncanonical NF-kB signaling" XP_046743714.1 2 Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198 "Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis" XP_046744286.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046744777.1 8 Reactome: R-HSA-9639288;Reactome: R-HSA-3371571;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-8943724;Reactome: R-HSA-165159 "Amino acids regulate mTORC1";"HSF1-dependent transactivation";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Macroautophagy";"Regulation of PTEN gene transcription";"mTOR signalling" XP_046736819.1 1 Reactome: R-HSA-5676934 "Protein repair" XP_046753604.1 1 Reactome: R-HSA-73621 "Pyrimidine catabolism" XP_046749782.1 5 Reactome: R-HSA-5673001;Reactome: R-HSA-1257604;Reactome: R-HSA-109704;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558 "RAF/MAP kinase cascade";"PIP3 activates AKT signaling";"PI3K Cascade";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" XP_046736478.1 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" XP_046754062.1 6 Reactome: R-HSA-111367;Reactome: R-HSA-77588;Reactome: R-HSA-73856;Reactome: R-HSA-72165;Reactome: R-HSA-191859;Reactome: R-HSA-72163 "SLBP independent Processing of Histone Pre-mRNAs";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Minor Pathway";"snRNP Assembly";"mRNA Splicing - Major Pathway" XP_046748968.1 1 Reactome: R-HSA-189451 "Heme biosynthesis" XP_046747950.1 1 Reactome: R-HSA-427359 "SIRT1 negatively regulates rRNA expression" XP_046738217.1 16 Reactome: R-HSA-8951664;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167152;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-9010553;Reactome: R-HSA-167290;Reactome: R-HSA-1234176;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-983168;Reactome: R-HSA-180585 "Neddylation";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"Regulation of expression of SLITs and ROBOs";"Pausing and recovery of HIV elongation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Antigen processing: Ubiquitination & Proteasome degradation";"Vif-mediated degradation of APOBEC3G" XP_046751095.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046743274.1 6 Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733 "Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis" XP_046738688.1 2 Reactome: R-HSA-6807878;Reactome: R-HSA-6811434 "COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046744683.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046746956.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway" XP_046746980.1 58 Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-180585;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-1236974;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-8939902;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-5689901;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-450408;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-6798695;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236 "The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Vif-mediated degradation of APOBEC3G";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Downstream TCR signaling";"UCH proteinases";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"ER-Phagosome pathway";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX2 expression and activity";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Metalloprotease DUBs";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Neutrophil degranulation";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs" XP_046743436.1 1 Reactome: R-HSA-5624958 "ARL13B-mediated ciliary trafficking of INPP5E" XP_046742133.1 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" XP_046739303.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046741110.1 4 Reactome: R-HSA-8953750;Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-1362277 "Transcriptional Regulation by E2F6";"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by DREAM complex" XP_046754139.1 1 Reactome: R-HSA-5617833 "Cilium Assembly" XP_046736342.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046747739.1 5 MetaCyc: PWY-6580;KEGG: 04070+3.1.3.64;Reactome: R-HSA-1660499;MetaCyc: PWY-6368;KEGG: 00562+3.1.3.64 "Phosphatidylinositol biosynthesis I (bacteria)";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"3-phosphoinositide degradation";"Inositol phosphate metabolism" XP_046751360.1 2 KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10 "One carbon pool by folate";"Glycine, serine and threonine metabolism" XP_046750532.1 37 Reactome: R-HSA-1169408;Reactome: R-HSA-9639288;Reactome: R-HSA-68877;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-168276;Reactome: R-HSA-204005;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-168333;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-159227;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-5663220;Reactome: R-HSA-5578749;Reactome: R-HSA-159231;Reactome: R-HSA-983170;Reactome: R-HSA-2500257;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-141444 "ISG15 antiviral mechanism";"Amino acids regulate mTORC1";"Mitotic Prometaphase";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"NS1 Mediated Effects on Host Pathways";"COPII-mediated vesicle transport";"HCMV Early Events";"MHC class II antigen presentation";"NEP/NS2 Interacts with the Cellular Export Machinery";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP independent Mature mRNA";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"RHO GTPases Activate Formins";"Transcriptional regulation by small RNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Resolution of Sister Chromatid Cohesion";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046747010.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046746294.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046749604.1 8 MetaCyc: PWY-7980;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2 "ATP biosynthesis";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Oxidative phosphorylation";"Photosynthesis" XP_046744099.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046747861.1 2 Reactome: R-HSA-2564830;Reactome: R-HSA-5693554 "Cytosolic iron-sulfur cluster assembly";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" XP_046734690.1 3 Reactome: R-HSA-983189;Reactome: R-HSA-390471;Reactome: R-HSA-6811434 "Kinesins";"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046739221.1 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" XP_046745882.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046735010.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046738894.1 14 Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-1632852;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-5620924;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-9609690 "EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"Macroautophagy";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"Intraflagellar transport";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"HCMV Early Events" XP_046739704.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" XP_046752884.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046747359.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046743958.1 4 KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"DARPP-32 events";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046746535.1 5 KEGG: 00230+2.7.4.10;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219 "Purine metabolism";"Thiamine metabolism";"Purine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis" XP_046744125.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046751104.1 3 Reactome: R-HSA-112311;Reactome: R-HSA-1483191;Reactome: R-HSA-422085 "Neurotransmitter clearance";"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin" XP_046733896.1 8 Reactome: R-HSA-6804757;Reactome: R-HSA-8866652;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-8948747;Reactome: R-HSA-5689880 "Regulation of TP53 Degradation";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Regulation of PTEN localization";"Ub-specific processing proteases" XP_046737469.1 4 Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387 "Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling" XP_046735749.1 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" XP_046736027.1 5 Reactome: R-HSA-6811440;Reactome: R-HSA-8856825;Reactome: R-HSA-432722;Reactome: R-HSA-8856828;Reactome: R-HSA-6798695 "Retrograde transport at the Trans-Golgi-Network";"Cargo recognition for clathrin-mediated endocytosis";"Golgi Associated Vesicle Biogenesis";"Clathrin-mediated endocytosis";"Neutrophil degranulation" XP_046749806.1 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" XP_046735309.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046737244.1 5 MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;Reactome: R-HSA-189085;MetaCyc: PWY-6902 "Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Digestion of dietary carbohydrate";"Chitin degradation II (Vibrio)" XP_046737352.1 4 Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394 "Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER" XP_046740053.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046739051.1 5 KEGG: 00531+3.1.6.14;Reactome: R-HSA-2206305;Reactome: R-HSA-2022857;Reactome: R-HSA-6798695;Reactome: R-HSA-432720 "Glycosaminoglycan degradation";"MPS IIID - Sanfilippo syndrome D";"Keratan sulfate degradation";"Neutrophil degranulation";"Lysosome Vesicle Biogenesis" XP_046736877.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046734628.1 31 MetaCyc: PWY-5971;MetaCyc: PWY-7664;MetaCyc: PWY-7663;MetaCyc: PWY-6113;Reactome: R-HSA-75105;MetaCyc: PWY-6282;MetaCyc: PWY-5989;MetaCyc: PWYG-321;MetaCyc: PWY-5142;MetaCyc: PWY-8047;MetaCyc: PWY-6519;MetaCyc: PWY-7388;MetaCyc: PWY-5367;MetaCyc: PWY-6799;MetaCyc: PWY-5973;MetaCyc: PWY-4381;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5966-1;Reactome: R-HSA-199220;Reactome: R-HSA-9029558;MetaCyc: PWY-8012;MetaCyc: PWY-8049;Reactome: R-HSA-163765;MetaCyc: PWY-5366;MetaCyc: PWY-7746;MetaCyc: PWY-7723;MetaCyc: PWY-5994;MetaCyc: PWY-5147;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-2426168;MetaCyc: PWY-7858 "Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis IV (anaerobic)";"Gondoate biosynthesis (anaerobic)";"Superpathway of mycolate biosynthesis";"Fatty acyl-CoA biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Stearate biosynthesis II (bacteria and plants)";"";"Acyl-[acyl-carrier protein] thioesterase pathway";"Bryostatin biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Mupirocin biosynthesis";"Pederin biosynthesis";"ChREBP activates metabolic gene expression";"Palmitoleate biosynthesis II (plants and bacteria)";"Mycobacterial sulfolipid biosynthesis";"Bacterial bioluminescence";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Oleate biosynthesis I (plants)";"Biotin metabolism";"Activation of gene expression by SREBF (SREBP)";"(5Z)-dodecenoate biosynthesis II" XP_046749711.1 1 Reactome: R-HSA-8850843 "Phosphate bond hydrolysis by NTPDase proteins" XP_046736596.1 4 Reactome: R-HSA-2022090;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216;Reactome: R-HSA-1650814 "Assembly of collagen fibrils and other multimeric structures";"Collagen degradation";"Collagen chain trimerization";"Collagen biosynthesis and modifying enzymes" XP_046752123.1 1 Reactome: R-HSA-72165 "mRNA Splicing - Minor Pathway" XP_046752130.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046751023.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046738775.1 10 MetaCyc: PWY-3821;MetaCyc: PWY-7344;MetaCyc: PWY-6317;Reactome: R-HSA-70370;Reactome: R-HSA-5609977;KEGG: 00520+5.1.3.2;MetaCyc: PWY-7328;KEGG: 00052+5.1.3.2;MetaCyc: PWY-6397;MetaCyc: PWY-6527 "D-galactose detoxification";"UDP-alpha-D-galactose biosynthesis";"D-galactose degradation I (Leloir pathway)";"Galactose catabolism";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Amino sugar and nucleotide sugar metabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Galactose metabolism";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Stachyose degradation" XP_046751979.1 7 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046738999.1 7 MetaCyc: PWY-5686;MetaCyc: PWY-7790;KEGG: 00240+4.1.1.23;Reactome: R-HSA-500753;KEGG: 00983+2.4.2.10;KEGG: 00240+2.4.2.10;MetaCyc: PWY-7791 "UMP biosynthesis I";"UMP biosynthesis II";"Pyrimidine metabolism";"Pyrimidine biosynthesis";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"UMP biosynthesis III" XP_046742618.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046746823.1 27 Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-3108214;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-168276 "Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"HCMV Late Events";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"NS1 Mediated Effects on Host Pathways" XP_046747436.1 2 Reactome: R-HSA-195253;Reactome: R-HSA-5689896 "Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases" XP_046739533.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046744184.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046742988.1 1 Reactome: R-HSA-1655829 "Regulation of cholesterol biosynthesis by SREBP (SREBF)" XP_046749381.1 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" XP_046741955.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046745711.1 4 Reactome: R-HSA-77075;Reactome: R-HSA-167160;MetaCyc: PWY-7375;Reactome: R-HSA-72086 "RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Mrna capping I";"mRNA Capping" XP_046751781.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046744633.1 3 MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1 "Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism" XP_046743747.1 4 Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination" XP_046738493.1 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" XP_046751761.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046746320.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046752187.1 3 MetaCyc: PWY-6368;MetaCyc: PWY-6367;KEGG: 04070+3.1.3.78 "3-phosphoinositide degradation";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system" XP_046736798.1 10 Reactome: R-HSA-70171;KEGG: 00051+2.7.1.11;MetaCyc: PWY-5484;KEGG: 00680+2.7.1.11;MetaCyc: PWY-1042;MetaCyc: PWY-7385;MetaCyc: PWY-1861;KEGG: 00030+2.7.1.11;KEGG: 00010+2.7.1.11;KEGG: 00052+2.7.1.11 "Glycolysis";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis";"Galactose metabolism" XP_046749581.1 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" XP_046735563.1 1 Reactome: R-HSA-419771 "Opsins" XP_046743164.1 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" XP_046738500.1 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" XP_046740075.1 5 Reactome: R-HSA-9610379;Reactome: R-HSA-917729;Reactome: R-HSA-9615710;Reactome: R-HSA-162588;Reactome: R-HSA-174490 "HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy";"Budding and maturation of HIV virion";"Membrane binding and targetting of GAG proteins" XP_046739466.1 7 Reactome: R-HSA-1834949;Reactome: R-HSA-73780;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-73980 "Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination" XP_046741236.1 4 Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-917977 "Insulin receptor recycling";"ROS and RNS production in phagocytes";"Ion channel transport";"Transferrin endocytosis and recycling" XP_046750391.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway" XP_046751490.1 4 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-76066 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" XP_046743210.1 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" XP_046743844.1 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" XP_046738763.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046740242.1 19 KEGG: 00680+1.1.1.37;MetaCyc: PWY-8086;MetaCyc: PWY-5690;MetaCyc: PWY-561;MetaCyc: PWY-6969;Reactome: R-HSA-70263;KEGG: 00630+1.1.1.37;KEGG: 00270+1.1.1.37;KEGG: 00720+1.1.1.37;MetaCyc: PWY-5913;KEGG: 00620+1.1.1.37;MetaCyc: PWY-7115;KEGG: 00020+1.1.1.37;MetaCyc: PWY-5392;MetaCyc: PWY-1622;Reactome: R-HSA-71403;MetaCyc: PWY-7383;KEGG: 00710+1.1.1.37;MetaCyc: PWY-6728 "Methane metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"TCA cycle II (plants and fungi)";"Superpathway of glyoxylate cycle and fatty acid degradation";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Gluconeogenesis";"Glyoxylate and dicarboxylate metabolism";"Cysteine and methionine metabolism";"Carbon fixation pathways in prokaryotes";"Partial TCA cycle (obligate autotrophs)";"Pyruvate metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Citrate cycle (TCA cycle)";"Reductive TCA cycle II";"Formaldehyde assimilation I (serine pathway)";"Citric acid cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Carbon fixation in photosynthetic organisms";"Methylaspartate cycle" XP_046745872.1 4 Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3 "Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism" XP_046749276.1 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" XP_046743903.1 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" XP_046742877.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046749684.1 14 MetaCyc: PWY-5667;MetaCyc: PWY-7587;MetaCyc: PWY-7589;KEGG: 00564+2.3.1.51;MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7411;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-8055;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-5981 "CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Palmitoleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"Plasmalogen biosynthesis";"Synthesis of PA";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III" XP_046741157.1 3 MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2 "Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism" XP_046740853.1 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" XP_046740158.1 2 Reactome: R-HSA-8866904;Reactome: R-HSA-8866907 "Negative regulation of activity of TFAP2 (AP-2) family transcription factors";"Activation of the TFAP2 (AP-2) family of transcription factors" XP_046741007.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046739220.1 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" XP_046743687.1 7 MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5466;MetaCyc: PWY-5469;MetaCyc: PWY-6824;MetaCyc: PWY-7445;MetaCyc: PWY-7214 "Betanidin degradation";"Phenylpropanoid biosynthesis";"Matairesinol biosynthesis";"Sesamin biosynthesis";"Justicidin B biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)" XP_046735835.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046751693.1 2 Reactome: R-HSA-3214847;Reactome: R-HSA-6804758 "HATs acetylate histones";"Regulation of TP53 Activity through Acetylation" XP_046744790.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046735573.1 1 Reactome: R-HSA-419771 "Opsins" XP_046743313.1 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" XP_046752229.1 12 MetaCyc: PWY-5855;MetaCyc: PWY-5856;Reactome: R-HSA-2142789;MetaCyc: PWY-5873;MetaCyc: PWY-7230;MetaCyc: PWY-6708;MetaCyc: PWY-5870;KEGG: 00130+1.14.99.60;MetaCyc: PWY-5857;MetaCyc: PWY-5871;MetaCyc: PWY-5872;MetaCyc: PWY-7233 "Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)" XP_046741566.1 3 Reactome: R-HSA-5358565;Reactome: R-HSA-5632928;Reactome: R-HSA-5632968 "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH2";"Defective Mismatch Repair Associated With MSH6" XP_046741732.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-8849473 "Major pathway of rRNA processing in the nucleolus and cytosol";"PTK6 Expression" XP_046739396.1 4 MetaCyc: PWY-6922;MetaCyc: PWY-5737;KEGG: 00330+1.5.5.2;Reactome: R-HSA-70688 "L-Ndelta-acetylornithine biosynthesis";"(5R)-carbapenem carboxylate biosynthesis";"Arginine and proline metabolism";"Proline catabolism" XP_046746478.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" XP_046751154.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046737020.1 4 MetaCyc: PWY-801;KEGG: 00270+4.2.1.22;Reactome: R-HSA-1614603;KEGG: 00260+4.2.1.22 "Homocysteine and cysteine interconversion";"Cysteine and methionine metabolism";"Cysteine formation from homocysteine";"Glycine, serine and threonine metabolism" XP_046741455.1 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" XP_046749808.1 1 Reactome: R-HSA-70350 "Fructose catabolism" XP_046737376.1 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" XP_046741050.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046741971.1 1 Reactome: R-HSA-901032 "ER Quality Control Compartment (ERQC)" XP_046744220.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046746492.1 1 Reactome: R-HSA-1614517 "Sulfide oxidation to sulfate" XP_046750850.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046734463.1 5 KEGG: 00520+2.7.1.6;MetaCyc: PWY-6527;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6317 "Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"Galactose metabolism";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)" XP_046748569.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046745316.1 14 Reactome: R-HSA-426486;Reactome: R-HSA-9029569;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-8934593;Reactome: R-HSA-5628897;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-426496;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-203927;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692 "Small interfering RNA (siRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Regulation of RUNX1 Expression and Activity";"TP53 Regulates Metabolic Genes";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"Post-transcriptional silencing by small RNAs";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MicroRNA (miRNA) biogenesis";"Ca2+ pathway";"Regulation of MECP2 expression and activity" XP_046739802.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046747280.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046750210.1 10 Reactome: R-HSA-5676590;Reactome: R-HSA-5684264;Reactome: R-HSA-2565942;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-202424;Reactome: R-HSA-8951664;Reactome: R-HSA-5607764;Reactome: R-HSA-5607761 "NIK-->noncanonical NF-kB signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Regulation of PLK1 Activity at G2/M Transition";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Downstream TCR signaling";"Neddylation";"CLEC7A (Dectin-1) signaling";"Dectin-1 mediated noncanonical NF-kB signaling" XP_046734562.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046747731.1 3 Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination" XP_046753218.1 3 Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621 "Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism" XP_046750388.1 7 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046747274.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046739495.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046742898.1 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" XP_046744009.1 4 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"DARPP-32 events" XP_046747508.1 5 KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922 "Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)" XP_046736341.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046747334.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046741004.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046739723.1 14 MetaCyc: PWY-7589;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5981;MetaCyc: PWY-7417;MetaCyc: PWY-8055;MetaCyc: PWY-8053 "Palmitoleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Plasmalogen biosynthesis";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phospholipid remodeling (phosphatidate, yeast)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II" XP_046750786.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046740585.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046750450.1 2 Reactome: R-HSA-6782315;Reactome: R-HSA-6787450 "tRNA modification in the nucleus and cytosol";"tRNA modification in the mitochondrion" XP_046733995.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046752834.1 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" XP_046747850.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046743100.1 4 Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-674695;Reactome: R-HSA-75955 "Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation" XP_046739324.1 1 Reactome: R-HSA-1483255 "PI Metabolism" XP_046741981.1 2 Reactome: R-HSA-72165;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" XP_046739474.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046741840.1 1 Reactome: R-HSA-71384 "Ethanol oxidation" XP_046740089.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046748580.1 10 Reactome: R-HSA-9627069;Reactome: R-HSA-111457;Reactome: R-HSA-3299685;Reactome: R-HSA-2151201;Reactome: R-HSA-5628897;Reactome: R-HSA-111459;Reactome: R-HSA-111464;Reactome: R-HSA-111463;Reactome: R-HSA-111458;Reactome: R-HSA-611105 "Regulation of the apoptosome activity";"Release of apoptotic factors from the mitochondria";"Detoxification of Reactive Oxygen Species";"Transcriptional activation of mitochondrial biogenesis";"TP53 Regulates Metabolic Genes";"Activation of caspases through apoptosome-mediated cleavage";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"SMAC (DIABLO) binds to IAPs";"Formation of apoptosome";"Respiratory electron transport" XP_046742723.1 6 MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463 "Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis" XP_046739312.1 13 Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-9633012 "L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046742050.1 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" XP_046738468.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046744381.1 12 Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436 "Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic" XP_046747136.1 9 Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-2173796;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-6807505 "Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA polymerase II transcribes snRNA genes" XP_046741816.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046749707.1 1 Reactome: R-HSA-373753 "Nephrin family interactions" XP_046749374.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046735310.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046735481.1 3 Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066 "RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" XP_046745060.1 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" XP_046743608.1 3 KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3;MetaCyc: PWY-6317 "Galactose metabolism";"Glycolysis / Gluconeogenesis";"D-galactose degradation I (Leloir pathway)" XP_046736007.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046751409.1 3 Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648 "Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK" XP_046741393.1 6 MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463 "Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis" XP_046734455.1 1 Reactome: R-HSA-176974 "Unwinding of DNA" XP_046742042.1 6 MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463 "Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis" XP_046747545.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046750486.1 3 KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508;Reactome: R-HSA-418597 "Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"G alpha (z) signalling events" XP_046742360.1 1 Reactome: R-HSA-2151201 "Transcriptional activation of mitochondrial biogenesis" XP_046749349.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046737902.1 24 Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-380320;Reactome: R-HSA-437239;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-6811436;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-9646399;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"HCMV Early Events";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"Recruitment of NuMA to mitotic centrosomes";"Recycling pathway of L1";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Cilium Assembly";"COPI-independent Golgi-to-ER retrograde traffic";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Aggrephagy";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Mitotic Prometaphase";"RHO GTPases Activate Formins" XP_046745334.1 5 MetaCyc: PWY-7536;KEGG: 00860+2.3.1.37;KEGG: 00260+2.3.1.37;Reactome: R-HSA-189451;MetaCyc: PWY-5189 "2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Porphyrin and chlorophyll metabolism";"Glycine, serine and threonine metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)" XP_046741201.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046748622.1 5 MetaCyc: PWY-6527;KEGG: 00561+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00052+3.2.1.22 "Stachyose degradation";"Glycerolipid metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Galactose metabolism" XP_046741058.1 1 Reactome: R-HSA-70350 "Fructose catabolism" XP_046740957.1 1 Reactome: R-HSA-162658 "Golgi Cisternae Pericentriolar Stack Reorganization" XP_046739832.1 1 Reactome: R-HSA-5693565 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" XP_046741013.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046735059.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046736280.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046740880.1 5 MetaCyc: PWY-7176;MetaCyc: PWY-7177;Reactome: R-HSA-499943;MetaCyc: PWY-7185;KEGG: 00240+6.3.4.2 "UTP and CTP de novo biosynthesis";"UTP and CTP dephosphorylation II";"Interconversion of nucleotide di- and triphosphates";"UTP and CTP dephosphorylation I";"Pyrimidine metabolism" XP_046736704.1 28 Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-6782210;Reactome: R-HSA-3371511;Reactome: R-HSA-912446;Reactome: R-HSA-5358606;Reactome: R-HSA-174437;Reactome: R-HSA-3371453;Reactome: R-HSA-5696397;Reactome: R-HSA-5696400;Reactome: R-HSA-6783310;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-110320;Reactome: R-HSA-68962;Reactome: R-HSA-5651801;Reactome: R-HSA-5685938;Reactome: R-HSA-5655862;Reactome: R-HSA-6782135;Reactome: R-HSA-5693616;Reactome: R-HSA-5656121;Reactome: R-HSA-5696395;Reactome: R-HSA-5358565;Reactome: R-HSA-5656169;Reactome: R-HSA-110312;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-69166 "Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HSF1 activation";"Meiotic recombination";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Removal of the Flap Intermediate from the C-strand";"Regulation of HSF1-mediated heat shock response";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Dual Incision in GG-NER";"Fanconi Anemia Pathway";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Translesion Synthesis by POLH";"Activation of the pre-replicative complex";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Single Strand Annealing (SSA)";"Translesion synthesis by POLK";"Dual incision in TC-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Translesion synthesis by POLI";"Formation of Incision Complex in GG-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Termination of translesion DNA synthesis";"Translesion synthesis by REV1";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate" XP_046735292.1 2 Reactome: R-HSA-8873719;Reactome: R-HSA-8876198 "RAB geranylgeranylation";"RAB GEFs exchange GTP for GDP on RABs" XP_046752339.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046734288.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046734793.1 6 Reactome: R-HSA-2022090;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814;Reactome: R-HSA-8948216 "Assembly of collagen fibrils and other multimeric structures";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Collagen degradation";"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization" XP_046750812.1 13 Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046744844.1 2 MetaCyc: PWY-6502;Reactome: R-HSA-2393930 "8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins" XP_046736148.1 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" XP_046750025.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046754100.1 4 Reactome: R-HSA-499943;Reactome: R-HSA-2162123;Reactome: R-HSA-6798695;KEGG: 00590+5.3.99.3 "Interconversion of nucleotide di- and triphosphates";"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)";"Neutrophil degranulation";"Arachidonic acid metabolism" XP_046745795.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046748251.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046741658.1 2 Reactome: R-HSA-373752;Reactome: R-HSA-525793 "Netrin-1 signaling";"Myogenesis" XP_046753967.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046740545.1 4 KEGG: 00513+2.4.1.260;KEGG: 00510+2.4.1.260;Reactome: R-HSA-446193;Reactome: R-HSA-4720489 "Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG12 causes ALG12-CDG (CDG-1g)" XP_046752620.1 3 KEGG: 00130+4.1.1.90;Reactome: R-HSA-159740;MetaCyc: PWY-7999 "Ubiquinone and other terpenoid-quinone biosynthesis";"Gamma-carboxylation of protein precursors";"Vitamin K-epoxide cycle" XP_046750421.1 6 Reactome: R-HSA-8951430;Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-4411364;Reactome: R-HSA-201722;Reactome: R-HSA-4086398 "RUNX3 regulates WNT signaling";"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Formation of the beta-catenin:TCF transactivating complex";"Ca2+ pathway" XP_046754064.1 6 Reactome: R-HSA-111367;Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-73856;Reactome: R-HSA-191859;Reactome: R-HSA-77588 "SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Termination";"snRNP Assembly";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" XP_046740214.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046749574.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046746735.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046744813.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046750144.1 8 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-418889;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Caspase activation via Dependence Receptors in the absence of ligand";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046739580.1 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" XP_046752670.1 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" XP_046753213.1 19 Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-9649948;Reactome: R-HSA-438066;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5576892;Reactome: R-HSA-5673000;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-6802946;Reactome: R-HSA-111932;Reactome: R-HSA-9620244;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692 "Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Signaling downstream of RAS mutants";"Unblocking of NMDA receptors, glutamate binding and activation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"Phase 0 - rapid depolarisation";"RAF activation";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by moderate kinase activity BRAF mutants";"CaMK IV-mediated phosphorylation of CREB";"Long-term potentiation";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity" XP_046746698.1 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" XP_046754135.1 2 Reactome: R-HSA-418594;Reactome: R-HSA-6814122 "G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" XP_046751065.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046736821.1 15 Reactome: R-HSA-5467333;Reactome: R-HSA-5339716;Reactome: R-HSA-5689896;Reactome: R-HSA-3769402;Reactome: R-HSA-111465;Reactome: R-HSA-195253;Reactome: R-HSA-5467340;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-5358752;Reactome: R-HSA-5467348;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-5467337;Reactome: R-HSA-196299 "APC truncation mutants are not K63 polyubiquitinated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Ovarian tumor domain proteases";"Deactivation of the beta-catenin transactivating complex";"Apoptotic cleavage of cellular proteins";"Degradation of beta-catenin by the destruction complex";"AXIN missense mutants destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade" XP_046744589.1 18 Reactome: R-HSA-5689901;Reactome: R-HSA-5685938;Reactome: R-HSA-6796648;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693565;MetaCyc: PWY-7511;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5693616;Reactome: R-HSA-5693571;Reactome: R-HSA-912446;Reactome: R-HSA-3108214;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-1221632;Reactome: R-HSA-69473;Reactome: R-HSA-8953750 "Metalloprotease DUBs";"HDR through Single Strand Annealing (SSA)";"TP53 Regulates Transcription of DNA Repair Genes";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Protein ubiquitination";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Presynaptic phase of homologous DNA pairing and strand exchange";"Nonhomologous End-Joining (NHEJ)";"Meiotic recombination";"SUMOylation of DNA damage response and repair proteins";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Meiotic synapsis";"G2/M DNA damage checkpoint";"Transcriptional Regulation by E2F6" XP_046741237.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046733762.1 14 MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7619;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-7725 "(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis V (8-detaturase, mammals)" XP_046750174.1 3 Reactome: R-HSA-3928662;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213 "EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs" XP_046745804.1 1 Reactome: R-HSA-912446 "Meiotic recombination" XP_046745343.1 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" XP_046737681.1 1 Reactome: R-HSA-428890 "Role of ABL in ROBO-SLIT signaling" XP_046752039.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection" XP_046744935.1 1 Reactome: R-HSA-5368286 "Mitochondrial translation initiation" XP_046747434.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046736882.1 2 KEGG: 00970+6.1.1.7;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" XP_046742037.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046747243.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046753928.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046737769.1 5 MetaCyc: PWY-7082;MetaCyc: PWY-3781;KEGG: 00190+7.1.1.8;MetaCyc: PWY-7279;MetaCyc: PWY-6692 "Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Aerobic respiration I (cytochrome c)";"Oxidative phosphorylation";"Aerobic respiration II (cytochrome c) (yeast)";"Fe(II) oxidation" XP_046749217.1 10 KEGG: 00332+1.2.1.41;KEGG: 00330+2.7.2.11+1.2.1.41;Reactome: R-HSA-8964539;KEGG: 00332+2.7.2.11+1.2.1.41;KEGG: 00330+2.7.2.11;KEGG: 00332+2.7.2.11;MetaCyc: PWY-6922;KEGG: 00330+1.2.1.41+2.7.2.11;KEGG: 00330+1.2.1.41;KEGG: 00332+1.2.1.41+2.7.2.11 "Carbapenem biosynthesis";"Arginine and proline metabolism";"Glutamate and glutamine metabolism";"Carbapenem biosynthesis";"Arginine and proline metabolism";"Carbapenem biosynthesis";"L-Ndelta-acetylornithine biosynthesis";"Arginine and proline metabolism";"Arginine and proline metabolism";"Carbapenem biosynthesis" XP_046737980.1 3 Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594 "Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events" XP_046738283.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-204005 "RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport" XP_046752058.1 5 Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-983712 "ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Ion channel transport" XP_046744065.1 4 Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554 "HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" XP_046735477.1 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" XP_046753221.1 19 Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-6802946;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-9022692;Reactome: R-HSA-6802955;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-399719;Reactome: R-HSA-442982;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-6802952;Reactome: R-HSA-5673000;Reactome: R-HSA-438066;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-9649948 "Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Signaling by moderate kinase activity BRAF mutants";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Regulation of MECP2 expression and activity";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Signaling by BRAF and RAF fusions";"RAF activation";"Unblocking of NMDA receptors, glutamate binding and activation";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"Signaling downstream of RAS mutants" XP_046737477.1 7 Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942 "Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition" XP_046753665.1 4 MetaCyc: PWY-6855;MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14 "Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism" XP_046735642.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046752117.1 3 Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-383280 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"Nuclear Receptor transcription pathway" XP_046735140.1 5 MetaCyc: PWY-4983;KEGG: 00220+1.14.13.39;KEGG: 00330+1.14.13.39;Reactome: R-HSA-1222556;Reactome: R-HSA-392154 "Nitric oxide biosynthesis II (mammals)";"Arginine biosynthesis";"Arginine and proline metabolism";"ROS and RNS production in phagocytes";"Nitric oxide stimulates guanylate cyclase" XP_046753912.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046739479.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046738173.1 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" XP_046752110.1 2 Reactome: R-HSA-1362409;Reactome: R-HSA-1268020 "Mitochondrial iron-sulfur cluster biogenesis";"Mitochondrial protein import" XP_046747433.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046749701.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046734513.1 3 Reactome: R-HSA-8874081;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171 "MET activates PTK2 signaling";"Laminin interactions";"Non-integrin membrane-ECM interactions" XP_046754133.1 2 Reactome: R-HSA-6814122;Reactome: R-HSA-418594 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events" XP_046753224.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046741757.1 11 Reactome: R-HSA-9614657;KEGG: 04926+2.7.11.1;Reactome: R-HSA-163680;Reactome: R-HSA-6804756;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-380972;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "FOXO-mediated transcription of cell death genes";"Relaxin signaling pathway";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Energy dependent regulation of mTOR by LKB1-AMPK";"Human cytomegalovirus infection";"Thermogenesis" XP_046754001.1 57 Reactome: R-HSA-1236974;Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-75815;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-983168;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-4641258;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8951664;Reactome: R-HSA-450408;Reactome: R-HSA-5658442;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-6798695;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880 "ER-Phagosome pathway";"Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Ubiquitin-dependent degradation of Cyclin D";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Degradation of DVL";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RAS by GAPs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"Neutrophil degranulation";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases" XP_046749132.1 7 Reactome: R-HSA-1362300;Reactome: R-HSA-69656;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-1538133;Reactome: R-HSA-69202;Reactome: R-HSA-156711 "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"G0 and Early G1";"Cyclin E associated events during G1/S transition";"Polo-like kinase mediated events" XP_046746899.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046736060.1 2 KEGG: 00062+3.1.2.22;Reactome: R-HSA-75105 "Fatty acid elongation";"Fatty acyl-CoA biosynthesis" XP_046739207.1 2 KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753 "Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism" XP_046737481.1 7 Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942 "AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition" XP_046735799.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046739462.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046736895.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046747940.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046752985.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046753703.1 4 Reactome: R-HSA-5655862;Reactome: R-HSA-110312;Reactome: R-HSA-5656121;Reactome: R-HSA-5656169 "Translesion synthesis by POLK";"Translesion synthesis by REV1";"Translesion synthesis by POLI";"Termination of translesion DNA synthesis" XP_046750577.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046753760.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046746246.1 4 Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823 "Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex" XP_046746974.1 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" XP_046744032.1 4 MetaCyc: PWY-6902;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822 "Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)" XP_046735473.1 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" XP_046747751.1 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" XP_046746952.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046737473.1 7 Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518 "Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2" XP_046753206.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046740705.1 3 Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213 "Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs" XP_046741912.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046750815.1 4 Reactome: R-HSA-8934903;Reactome: R-HSA-5205685;Reactome: R-HSA-936440;Reactome: R-HSA-1632852 "Receptor Mediated Mitophagy";"Pink/Parkin Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling";"Macroautophagy" XP_046741711.1 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" XP_046751710.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046749552.1 3 Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955 "Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation" XP_046745667.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046745851.1 4 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.17;KEGG: 00860+6.1.1.17;MetaCyc: PWY-5188 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)" XP_046744903.1 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" XP_046735118.1 16 Reactome: R-HSA-5099900;Reactome: R-HSA-182218;Reactome: R-HSA-2132295;Reactome: R-HSA-177504;Reactome: R-HSA-437239;Reactome: R-HSA-5140745;Reactome: R-HSA-8964038;Reactome: R-HSA-167590;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828;Reactome: R-HSA-196025;Reactome: R-HSA-164939;Reactome: R-HSA-8856825;Reactome: R-HSA-190873;Reactome: R-HSA-8866427;Reactome: R-HSA-416993 "WNT5A-dependent internalization of FZD4";"Nef Mediated CD8 Down-regulation";"MHC class II antigen presentation";"Retrograde neurotrophin signalling";"Recycling pathway of L1";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"LDL clearance";"Nef Mediated CD4 Down-regulation";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis";"Formation of annular gap junctions";"Nef mediated downregulation of CD28 cell surface expression";"Cargo recognition for clathrin-mediated endocytosis";"Gap junction degradation";"VLDLR internalisation and degradation";"Trafficking of GluR2-containing AMPA receptors" XP_046752920.1 3 Reactome: R-HSA-74259;Reactome: R-HSA-73621;Reactome: R-HSA-196807 "Purine catabolism";"Pyrimidine catabolism";"Nicotinate metabolism" XP_046750824.1 8 Reactome: R-HSA-69091;Reactome: R-HSA-69166;Reactome: R-HSA-68952;Reactome: R-HSA-69183;Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-174430;Reactome: R-HSA-113501 "Polymerase switching";"Removal of the Flap Intermediate";"DNA replication initiation";"Processive synthesis on the lagging strand";"Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand synthesis initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1" XP_046753810.1 5 Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-983170;Reactome: R-HSA-2132295;Reactome: R-HSA-204005 "Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"MHC class II antigen presentation";"COPII-mediated vesicle transport" XP_046743556.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046733709.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046738020.1 3 Reactome: R-HSA-2514859;KEGG: 00310+2.1.1.60;Reactome: R-HSA-8876725 "Inactivation, recovery and regulation of the phototransduction cascade";"Lysine degradation";"Protein methylation" XP_046744226.1 4 Reactome: R-HSA-1650814;Reactome: R-HSA-2214320;Reactome: R-HSA-2243919;Reactome: R-HSA-1474228 "Collagen biosynthesis and modifying enzymes";"Anchoring fibril formation";"Crosslinking of collagen fibrils";"Degradation of the extracellular matrix" XP_046742933.1 6 MetaCyc: PWY-7656;MetaCyc: PWY-6733;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;Reactome: R-HSA-9640463 "Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis" XP_046736317.1 4 Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-112308;Reactome: R-HSA-5576893 "Phase 0 - rapid depolarisation";"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase" XP_046741105.1 4 MetaCyc: PWY-7219;KEGG: 00250+6.3.4.4;Reactome: R-HSA-73817;KEGG: 00230+6.3.4.4 "Adenosine ribonucleotides de novo biosynthesis";"Alanine, aspartate and glutamate metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism" XP_046740777.1 33 MetaCyc: PWY-7118;KEGG: 00260+1.1.1.1;MetaCyc: PWY-6587;MetaCyc: PWY-6802;MetaCyc: PWY-5751;MetaCyc: PWY-3162;MetaCyc: PWY-5076;KEGG: 00350+1.1.1.1;MetaCyc: PWY-7396;MetaCyc: PWY-6333;MetaCyc: PWY-6871;MetaCyc: PWY-5057;MetaCyc: PWY-5079;Reactome: R-HSA-71384;KEGG: 00626+1.1.1.1;KEGG: 00680+1.1.1.284;KEGG: 00071+1.1.1.1;MetaCyc: PWY-7111;KEGG: 00010+1.1.1.1;MetaCyc: PWY-5480;KEGG: 00625+1.1.1.1;MetaCyc: PWY-5486;MetaCyc: PWY-1801;MetaCyc: PWY-5082;MetaCyc: PWY-6342;MetaCyc: PWY-5078;MetaCyc: PWY-7798;KEGG: 00980+1.1.1.1;KEGG: 00830+1.1.1.1;KEGG: 00592+1.1.1.1;MetaCyc: PWY-7013;MetaCyc: PWY-6313;KEGG: 00982+1.1.1.1 "Chitin degradation to ethanol";"Glycine, serine and threonine metabolism";"Pyruvate fermentation to ethanol III";"Salidroside biosynthesis";"Phenylethanol biosynthesis";"L-tryptophan degradation V (side chain pathway)";"L-leucine degradation III";"Tyrosine metabolism";"Butanol and isobutanol biosynthesis (engineered)";"Acetaldehyde biosynthesis I";"3-methylbutanol biosynthesis (engineered)";"L-valine degradation II";"L-phenylalanine degradation III";"Ethanol oxidation";"Naphthalene degradation";"Methane metabolism";"Fatty acid degradation";"Pyruvate fermentation to isobutanol (engineered)";"Glycolysis / Gluconeogenesis";"Pyruvate fermentation to ethanol I";"Chloroalkane and chloroalkene degradation";"Pyruvate fermentation to ethanol II";"Formaldehyde oxidation II (glutathione-dependent)";"L-methionine degradation III";"Noradrenaline and adrenaline degradation";"L-isoleucine degradation II";"Protein S-nitrosylation and denitrosylation";"Metabolism of xenobiotics by cytochrome P450";"Retinol metabolism";"alpha-Linolenic acid metabolism";"(S)-propane-1,2-diol degradation";"Serotonin degradation";"Drug metabolism - cytochrome P450" XP_046749559.1 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" XP_046736514.1 2 Reactome: R-HSA-983231;Reactome: R-HSA-5205685 "Factors involved in megakaryocyte development and platelet production";"Pink/Parkin Mediated Mitophagy" XP_046736693.1 4 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription" XP_046748078.1 56 Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-1236974;Reactome: R-HSA-75815;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-450408;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-8939902;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091 "UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"ER-Phagosome pathway";"Ubiquitin-dependent degradation of Cyclin D";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX2 expression and activity";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells" XP_046745852.1 11 MetaCyc: PWY-7124;MetaCyc: PWY-5913;MetaCyc: PWY-7268;KEGG: 00480+1.1.1.42;MetaCyc: PWY-6969;Reactome: R-HSA-71403;MetaCyc: PWY-7254;KEGG: 00720+1.1.1.42;MetaCyc: PWY-6549;MetaCyc: PWY-6728;KEGG: 00020+1.1.1.42 "Ethylene biosynthesis V (engineered)";"Partial TCA cycle (obligate autotrophs)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citric acid cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Carbon fixation pathways in prokaryotes";"L-glutamine biosynthesis III";"Methylaspartate cycle";"Citrate cycle (TCA cycle)" XP_046749378.1 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" XP_046746458.1 7 Reactome: R-HSA-5083633;Reactome: R-HSA-3000178;Reactome: R-HSA-9010553;Reactome: R-HSA-5083628;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;Reactome: R-HSA-3000171 "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"ECM proteoglycans";"Regulation of expression of SLITs and ROBOs";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Non-integrin membrane-ECM interactions" XP_046743613.1 7 MetaCyc: PWY-3385;Reactome: R-HSA-1483213;Reactome: R-HSA-1483191;MetaCyc: PWY-7782;KEGG: 00564+2.7.1.32+2.7.1.82;MetaCyc: PWY-7886;MetaCyc: PWY-7818 "Choline biosynthesis I";"Synthesis of PE";"Synthesis of PC";"Plasmalogen biosynthesis";"Glycerophospholipid metabolism";"Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)" XP_046747814.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046736846.1 15 Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-5358752;Reactome: R-HSA-5467348;Reactome: R-HSA-5467340;Reactome: R-HSA-4641262;Reactome: R-HSA-5358751;Reactome: R-HSA-111465;Reactome: R-HSA-195253;Reactome: R-HSA-3769402;Reactome: R-HSA-5467333;Reactome: R-HSA-5339716;Reactome: R-HSA-5689896 "APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"AXIN missense mutants destabilize the destruction complex";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S45 mutants of beta-catenin aren't phosphorylated";"Apoptotic cleavage of cellular proteins";"Degradation of beta-catenin by the destruction complex";"Deactivation of the beta-catenin transactivating complex";"APC truncation mutants are not K63 polyubiquitinated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Ovarian tumor domain proteases" XP_046746951.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-171319 "rRNA modification in the nucleus and cytosol";"Telomere Extension By Telomerase" XP_046750821.1 13 MetaCyc: PWY-2201;MetaCyc: PWY-5030;MetaCyc: PWY-2161;KEGG: 00670+6.3.4.3;MetaCyc: PWY-3841;KEGG: 00720+1.5.1.5+3.5.4.9;Reactome: R-HSA-196757;MetaCyc: PWY-5497;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-1722;MetaCyc: PWY-7909;MetaCyc: PWY-6613;KEGG: 00720+6.3.4.3 "Folate transformations I";"L-histidine degradation III";"Folate polyglutamylation";"One carbon pool by folate";"Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"Metabolism of folate and pterines";"Purine nucleobases degradation II (anaerobic)";"One carbon pool by folate";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Carbon fixation pathways in prokaryotes" XP_046734796.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046750903.1 3 Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916 "Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium" XP_046747660.1 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" XP_046741984.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046746671.1 5 Reactome: R-HSA-390450;Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-6814122 "Folding of actin by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" XP_046752154.1 56 Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-450408;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-8939902;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-1236974;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-180585 "Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX2 expression and activity";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"UCH proteinases";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"ER-Phagosome pathway";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G" XP_046744837.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046744792.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046740328.1 6 Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-456926;Reactome: R-HSA-399997 "G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Thrombin signalling through proteinase activated receptors (PARs)";"Acetylcholine regulates insulin secretion" XP_046749357.1 1 Reactome: R-HSA-8876725 "Protein methylation" XP_046753621.1 13 Reactome: R-HSA-450321;Reactome: R-HSA-975163;Reactome: R-HSA-5607764;Reactome: R-HSA-9020702;Reactome: R-HSA-9014325;Reactome: R-HSA-445989;Reactome: R-HSA-937042;Reactome: R-HSA-9645460;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-450302;Reactome: R-HSA-2871837 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"CLEC7A (Dectin-1) signaling";"Interleukin-1 signaling";"TICAM1,TRAF6-dependent induction of TAK1 complex";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"IRAK2 mediated activation of TAK1 complex";"Alpha-protein kinase 1 signaling pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"activated TAK1 mediates p38 MAPK activation";"FCERI mediated NF-kB activation" XP_046747254.1 1 Reactome: R-HSA-5689603 "UCH proteinases" XP_046748517.1 13 Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-9633012;Reactome: R-HSA-156902 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation" XP_046751970.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046748883.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046752861.1 1 Reactome: R-HSA-4419969 "Depolymerisation of the Nuclear Lamina" XP_046741333.1 10 Reactome: R-HSA-8936459;Reactome: R-HSA-3899300;Reactome: R-HSA-9022699;Reactome: R-HSA-9022702;Reactome: R-HSA-9022538;Reactome: R-HSA-400206;Reactome: R-HSA-9615017;Reactome: R-HSA-983231;Reactome: R-HSA-9022692;Reactome: R-HSA-427413 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of transcription cofactors";"MECP2 regulates neuronal receptors and channels";"MECP2 regulates transcription of neuronal ligands";"Loss of MECP2 binding ability to 5mC-DNA";"Regulation of lipid metabolism by PPARalpha";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Factors involved in megakaryocyte development and platelet production";"Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression" XP_046752989.1 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" XP_046751572.1 6 MetaCyc: PWY-5664;MetaCyc: PWY-6983;KEGG: 00790+4.2.3.12;MetaCyc: PWY-5663;Reactome: R-HSA-1474151;MetaCyc: PWY-7442 "Erythro-tetrahydrobiopterin biosynthesis II";"Threo-tetrahydrobiopterin biosynthesis";"Folate biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Drosopterin and aurodrosopterin biosynthesis" XP_046736838.1 15 Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-5358752;Reactome: R-HSA-5467348;Reactome: R-HSA-195253;Reactome: R-HSA-111465;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-5467340;Reactome: R-HSA-5689896;Reactome: R-HSA-5339716;Reactome: R-HSA-5467333;Reactome: R-HSA-3769402 "S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"Apoptotic cleavage of cellular proteins";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"AXIN missense mutants destabilize the destruction complex";"Ovarian tumor domain proteases";"Misspliced GSK3beta mutants stabilize beta-catenin";"APC truncation mutants are not K63 polyubiquitinated";"Deactivation of the beta-catenin transactivating complex" XP_046745556.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046734492.1 12 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416476;Reactome: R-HSA-194840;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-418885;Reactome: R-HSA-193648 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"G alpha (12/13) signalling events";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"G alpha (q) signalling events";"Rho GTPase cycle";"Human papillomavirus infection";"Relaxin signaling pathway";"DCC mediated attractive signaling";"NRAGE signals death through JNK" XP_046748509.1 3 Reactome: R-HSA-8854214;Reactome: R-HSA-8875656;Reactome: R-HSA-8856828 "TBC/RABGAPs";"MET receptor recycling";"Clathrin-mediated endocytosis" XP_046738071.1 2 Reactome: R-HSA-74217;KEGG: 00230+1.7.1.7 "Purine salvage";"Purine metabolism" XP_046741706.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" XP_046744492.1 14 KEGG: 00020+1.3.5.1;MetaCyc: PWY-5690;MetaCyc: PWY-7279;MetaCyc: PWY-4302;MetaCyc: PWY-561;KEGG: 00720+1.3.5.1;MetaCyc: PWY-3781;Reactome: R-HSA-611105;MetaCyc: PWY-6728;MetaCyc: PWY-7254;Reactome: R-HSA-71403;MetaCyc: PWY-6969;KEGG: 00650+1.3.5.1;KEGG: 00190+1.3.5.1 "Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Carbon fixation pathways in prokaryotes";"Aerobic respiration I (cytochrome c)";"Respiratory electron transport";"Methylaspartate cycle";"TCA cycle VII (acetate-producers)";"Citric acid cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Butanoate metabolism";"Oxidative phosphorylation" XP_046743930.1 12 KEGG: 00500+2.7.7.9;MetaCyc: PWY-7343;MetaCyc: PWY-7817;KEGG: 00561+2.7.7.9;MetaCyc: PWY-3801;KEGG: 00520+2.7.7.9;Reactome: R-HSA-173599;Reactome: R-HSA-3322077;MetaCyc: PWY-6527;KEGG: 00052+2.7.7.9;MetaCyc: PWY-7238;KEGG: 00040+2.7.7.9 "Starch and sucrose metabolism";"UDP-alpha-D-glucose biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Sucrose degradation II (sucrose synthase)";"Amino sugar and nucleotide sugar metabolism";"Formation of the active cofactor, UDP-glucuronate";"Glycogen synthesis";"Stachyose degradation";"Galactose metabolism";"Sucrose biosynthesis II";"Pentose and glucuronate interconversions" XP_046735904.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046736494.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046741750.1 5 MetaCyc: PWY-8010;KEGG: 00260+1.1.1.95;KEGG: 00680+1.1.1.95;Reactome: R-HSA-977347;KEGG: 00270+1.1.1.95 "L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Glycine, serine and threonine metabolism";"Methane metabolism";"Serine biosynthesis";"Cysteine and methionine metabolism" XP_046754130.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440 "COPI-mediated anterograde transport";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network" XP_046733771.1 2 Reactome: R-HSA-3238698;Reactome: R-HSA-373080 "WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)" XP_046746183.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046743740.1 2 Reactome: R-HSA-5696394;Reactome: R-HSA-5689603 "DNA Damage Recognition in GG-NER";"UCH proteinases" XP_046747255.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046743834.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046748390.1 27 Reactome: R-HSA-191859;Reactome: R-HSA-159227;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-168271;Reactome: R-HSA-168276;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-159230;Reactome: R-HSA-1169408 "snRNP Assembly";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"HCMV Late Events";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"Transport of Ribonucleoproteins into the Host Nucleus";"NS1 Mediated Effects on Host Pathways";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism" XP_046749653.1 8 KEGG: 00520+2.7.1.1;KEGG: 00524+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00521+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00052+2.7.1.1 "Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Glycolysis";"Streptomycin biosynthesis";"Fructose and mannose metabolism";"Starch and sucrose metabolism";"Glycolysis / Gluconeogenesis";"Galactose metabolism" XP_046747692.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046739688.1 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" XP_046733739.1 11 Reactome: R-HSA-983231;Reactome: R-HSA-8940973;Reactome: R-HSA-5663213;Reactome: R-HSA-8939236;KEGG: 04660+2.7.10.2;Reactome: R-HSA-69231;Reactome: R-HSA-5685938;Reactome: R-HSA-428890;Reactome: R-HSA-2029482;Reactome: R-HSA-5693565;Reactome: R-HSA-525793 "Factors involved in megakaryocyte development and platelet production";"RUNX2 regulates osteoblast differentiation";"RHO GTPases Activate WASPs and WAVEs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"T cell receptor signaling pathway";"Cyclin D associated events in G1";"HDR through Single Strand Annealing (SSA)";"Role of ABL in ROBO-SLIT signaling";"Regulation of actin dynamics for phagocytic cup formation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Myogenesis" XP_046747844.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046741059.1 3 Reactome: R-HSA-1369062;Reactome: R-HSA-8964058;Reactome: R-HSA-9029569 "ABC transporters in lipid homeostasis";"HDL remodeling";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" XP_046747802.1 8 Reactome: R-HSA-196025;Reactome: R-HSA-8856828;Reactome: R-HSA-3928665;Reactome: R-HSA-5099900;Reactome: R-HSA-5140745;Reactome: R-HSA-190873;Reactome: R-HSA-8856825;Reactome: R-HSA-432720 "Formation of annular gap junctions";"Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"WNT5A-dependent internalization of FZD4";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Gap junction degradation";"Cargo recognition for clathrin-mediated endocytosis";"Lysosome Vesicle Biogenesis" XP_046750944.1 4 MetaCyc: PWY-7494;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163;MetaCyc: PWY-3722 "Choline degradation IV";"Glycine, serine and threonine metabolism";"Choline catabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)" XP_046743029.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046737660.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046746078.1 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" XP_046746644.1 7 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046748350.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046748542.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046748742.1 2 Reactome: R-HSA-9020702;Reactome: R-HSA-6798695 "Interleukin-1 signaling";"Neutrophil degranulation" XP_046751824.1 1 Reactome: R-HSA-8876725 "Protein methylation" XP_046751843.1 1 Reactome: R-HSA-9633012 "Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046742436.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046740994.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046739744.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" XP_046743251.1 6 Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156827 "Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression" XP_046739299.1 3 KEGG: 00600+3.1.4.12;MetaCyc: PWY-7277;Reactome: R-HSA-1660662 "Sphingolipid metabolism";"Sphingolipid biosynthesis (mammals)";"Glycosphingolipid metabolism" XP_046739545.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046738240.1 5 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-3214815;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"HDACs deacetylate histones";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" XP_046735631.1 9 Reactome: R-HSA-3642279;Reactome: R-HSA-3645790;Reactome: R-HSA-2173789;Reactome: R-HSA-3304356;Reactome: R-HSA-2173791;Reactome: R-HSA-2173788;Reactome: R-HSA-3656535;Reactome: R-HSA-3656532;Reactome: R-HSA-5689603 "TGFBR2 MSI Frameshift Mutants in Cancer";"TGFBR2 Kinase Domain Mutants in Cancer";"TGF-beta receptor signaling activates SMADs";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Downregulation of TGF-beta receptor signaling";"TGFBR1 LBD Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"UCH proteinases" XP_046736640.1 6 KEGG: 00270+2.6.1.52;MetaCyc: PWY-8010;KEGG: 00750+2.6.1.52;KEGG: 00260+2.6.1.52;Reactome: R-HSA-977347;KEGG: 00680+2.6.1.52 "Cysteine and methionine metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Vitamin B6 metabolism";"Glycine, serine and threonine metabolism";"Serine biosynthesis";"Methane metabolism" XP_046736779.1 5 MetaCyc: PWY-6855;Reactome: R-HSA-189085;MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14 "Chitin degradation I (archaea)";"Digestion of dietary carbohydrate";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism" XP_046742962.1 33 Reactome: R-HSA-167162;Reactome: R-HSA-73772;Reactome: R-HSA-167246;Reactome: R-HSA-69656;Reactome: R-HSA-77075;Reactome: R-HSA-69231;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-427413;Reactome: R-HSA-73776;Reactome: R-HSA-113418;Reactome: R-HSA-73863;Reactome: R-HSA-8939236;Reactome: R-HSA-72086;Reactome: R-HSA-167161;Reactome: R-HSA-112382;Reactome: R-HSA-5696395;Reactome: R-HSA-76042;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-6782135;Reactome: R-HSA-167172;Reactome: R-HSA-6781827;Reactome: R-HSA-6796648;Reactome: R-HSA-75953;Reactome: R-HSA-73762;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-69273;Reactome: R-HSA-75955;Reactome: R-HSA-69202;Reactome: R-HSA-167200;Reactome: R-HSA-6782210 "RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"Cyclin A:Cdk2-associated events at S phase entry";"RNA Pol II CTD phosphorylation and interaction with CE";"Cyclin D associated events in G1";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Promoter Escape";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Termination";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"mRNA Capping";"HIV Transcription Initiation";"Formation of RNA Pol II elongation complex";"Formation of Incision Complex in GG-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Dual incision in TC-NER";"Transcription of the HIV genome";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Cyclin A/B1/B2 associated events during G2/M transition";"RNA Polymerase II Transcription Elongation";"Cyclin E associated events during G1/S transition";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER" XP_046737414.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression" XP_046745956.1 2 Reactome: R-HSA-376176;Reactome: R-HSA-202433 "Signaling by ROBO receptors";"Generation of second messenger molecules" XP_046750668.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046741108.1 4 Reactome: R-HSA-8953750;Reactome: R-HSA-69202;Reactome: R-HSA-1362277;Reactome: R-HSA-69656 "Transcriptional Regulation by E2F6";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry" XP_046739139.1 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" XP_046737149.1 5 Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-159231;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" XP_046745875.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" XP_046735637.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046748620.1 5 KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22 "Sphingolipid metabolism";"Glycerolipid metabolism";"Stachyose degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series" XP_046751192.1 5 Reactome: R-HSA-5694530;Reactome: R-HSA-2132295;Reactome: R-HSA-983170;Reactome: R-HSA-1655829;Reactome: R-HSA-204005 "Cargo concentration in the ER";"MHC class II antigen presentation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"COPII-mediated vesicle transport" XP_046742081.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046747856.1 2 Reactome: R-HSA-5339700;Reactome: R-HSA-4641265 "TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes" XP_046745971.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046735556.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046746188.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046736198.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046736126.1 5 Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72165 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Minor Pathway" XP_046735839.1 1 Reactome: R-HSA-6804756 "Regulation of TP53 Activity through Phosphorylation" XP_046734188.1 8 Reactome: R-HSA-70268;KEGG: 00010+1.1.1.27;KEGG: 00620+1.1.1.27;KEGG: 00640+1.1.1.27;KEGG: 00270+1.1.1.27;MetaCyc: PWY-6901;MetaCyc: PWY-5481;MetaCyc: PWY-8086 "Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Propanoate metabolism";"Cysteine and methionine metabolism";"Superpathway of glucose and xylose degradation";"Pyruvate fermentation to (S)-lactate";"(S)-lactate fermentation to propanoate, acetate and hydrogen" XP_046736170.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046744168.1 12 Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-141444 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046749365.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046743841.1 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" XP_046753841.1 7 Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes" XP_046751548.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046748765.1 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" XP_046735531.1 1 Reactome: R-HSA-419771 "Opsins" XP_046748151.1 4 Reactome: R-HSA-3371497;Reactome: R-HSA-8939211;Reactome: R-HSA-3371568;Reactome: R-HSA-9018519 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"ESR-mediated signaling";"Attenuation phase";"Estrogen-dependent gene expression" XP_046742264.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046747275.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046735335.1 1 Reactome: R-HSA-429958 "mRNA decay by 3' to 5' exoribonuclease" XP_046736207.1 13 Reactome: R-HSA-202433;Reactome: R-HSA-2871809;Reactome: R-HSA-1855204;Reactome: R-HSA-9027277;Reactome: R-HSA-2424491;MetaCyc: PWY-6367;Reactome: R-HSA-2871796;MetaCyc: PWY-8052;Reactome: R-HSA-2029485;MetaCyc: PWY-7039;MetaCyc: PWY-6351;KEGG: 04070+3.1.4.11;KEGG: 00562+3.1.4.11 "Generation of second messenger molecules";"FCERI mediated Ca+2 mobilization";"Synthesis of IP3 and IP4 in the cytosol";"Erythropoietin activates Phospholipase C gamma (PLCG)";"DAP12 signaling";"D-myo-inositol-5-phosphate metabolism";"FCERI mediated MAPK activation";"2-arachidonoylglycerol biosynthesis";"Role of phospholipids in phagocytosis";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism" XP_046737838.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046743443.1 1 Reactome: R-HSA-2022928 "HS-GAG biosynthesis" XP_046745360.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046738949.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046738886.1 10 KEGG: 00130+2.1.1.163;MetaCyc: PWY-7996;MetaCyc: PWY-5891;MetaCyc: PWY-5839;MetaCyc: PWY-5849;MetaCyc: PWY-5844;Reactome: R-HSA-2142789;MetaCyc: PWY-5890;MetaCyc: PWY-5895;MetaCyc: PWY-5892 "Ubiquinone and other terpenoid-quinone biosynthesis";"Menaquinol-4 biosynthesis I";"Menaquinol-11 biosynthesis";"Menaquinol-7 biosynthesis";"Menaquinol-6 biosynthesis";"Menaquinol-9 biosynthesis";"Ubiquinol biosynthesis";"Menaquinol-10 biosynthesis";"Menaquinol-13 biosynthesis";"Menaquinol-12 biosynthesis" XP_046733821.1 6 Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" XP_046749564.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046744118.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046734927.1 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" XP_046754090.1 6 Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6;Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;KEGG: 00380+1.11.1.6;Reactome: R-HSA-6798695 "Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism";"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Tryptophan metabolism";"Neutrophil degranulation" XP_046746685.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046745191.1 1 Reactome: R-HSA-5689877 "Josephin domain DUBs" XP_046748283.1 2 Reactome: R-HSA-194840;Reactome: R-HSA-8876198 "Rho GTPase cycle";"RAB GEFs exchange GTP for GDP on RABs" XP_046735604.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046750045.1 6 MetaCyc: PWY-7426;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952;MetaCyc: PWY-7920;Reactome: R-HSA-975578 "Complex N-linked glycan biosynthesis (vertebrates)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway" XP_046748600.1 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" XP_046748540.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046753491.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6784531 "Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus" XP_046752701.1 1 Reactome: R-HSA-418886 "Netrin mediated repulsion signals" XP_046738903.1 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" XP_046746121.1 9 Reactome: R-HSA-8856828;Reactome: R-HSA-9613829;Reactome: R-HSA-5678895;Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-5689880;Reactome: R-HSA-382556;Reactome: R-HSA-9646399;Reactome: R-HSA-5627083 "Clathrin-mediated endocytosis";"Chaperone Mediated Autophagy";"Defective CFTR causes cystic fibrosis";"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Ub-specific processing proteases";"ABC-family proteins mediated transport";"Aggrephagy";"RHO GTPases regulate CFTR trafficking" XP_046743569.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046751296.1 40 Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-6782135;Reactome: R-HSA-76042;Reactome: R-HSA-6781823;Reactome: R-HSA-112382;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-75953;Reactome: R-HSA-6796648;Reactome: R-HSA-9018519;Reactome: R-HSA-167172;Reactome: R-HSA-6781827;Reactome: R-HSA-72203;Reactome: R-HSA-6782210;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-5601884;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-203927;Reactome: R-HSA-6807505;Reactome: R-HSA-5578749;Reactome: R-HSA-73779;Reactome: R-HSA-5617472;Reactome: R-HSA-77075;Reactome: R-HSA-113418;Reactome: R-HSA-8851708;Reactome: R-HSA-72165;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-167287;Reactome: R-HSA-167161;Reactome: R-HSA-72163;Reactome: R-HSA-167238 "Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"Dual incision in TC-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of TC-NER Pre-Incision Complex";"Formation of RNA Pol II elongation complex";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"Estrogen-dependent gene expression";"Transcription of the HIV genome";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Processing of Capped Intron-Containing Pre-mRNA";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"MicroRNA (miRNA) biogenesis";"RNA polymerase II transcribes snRNA genes";"Transcriptional regulation by small RNAs";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of the Early Elongation Complex";"Signaling by FGFR2 IIIa TM";"mRNA Splicing - Minor Pathway";"mRNA Capping";"Viral Messenger RNA Synthesis";"HIV elongation arrest and recovery";"HIV Transcription Initiation";"mRNA Splicing - Major Pathway";"Pausing and recovery of Tat-mediated HIV elongation" XP_046736479.1 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" XP_046748627.1 6 Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72706 "Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046744644.1 2 Reactome: R-HSA-9033241;Reactome: R-HSA-389661 "Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation" XP_046746181.1 18 KEGG: 00400+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00270+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00710+2.6.1.1;MetaCyc: PWY-6638;MetaCyc: PWY-7383;MetaCyc: PWY-7117;MetaCyc: PWY-6642;KEGG: 00330+2.6.1.1;KEGG: 00960+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00950+2.6.1.1;KEGG: 00350+2.6.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-5913 "Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine biosynthesis";"Cysteine and methionine metabolism";"Alanine, aspartate and glutamate metabolism";"Novobiocin biosynthesis";"Phenylalanine metabolism";"Carbon fixation in photosynthetic organisms";"Sulfolactate degradation III";"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"(R)-cysteate degradation";"Arginine and proline metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Coenzyme M biosynthesis II";"Isoquinoline alkaloid biosynthesis";"Tyrosine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Partial TCA cycle (obligate autotrophs)" XP_046742438.1 2 Reactome: R-HSA-8936459;Reactome: R-HSA-3214841 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines" XP_046738792.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046739347.1 12 Reactome: R-HSA-9017802;Reactome: R-HSA-205043;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-3928665;Reactome: R-HSA-2979096;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700;Reactome: R-HSA-977225;Reactome: R-HSA-193692 "Noncanonical activation of NOTCH3";"NRIF signals cell death from the nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"EPH-ephrin mediated repulsion of cells";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Amyloid fiber formation";"Regulated proteolysis of p75NTR" XP_046748882.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046741015.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046748619.1 5 KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00052+3.2.1.22 "Glycerolipid metabolism";"Stachyose degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Galactose metabolism" XP_046741285.1 17 KEGG: 00240+2.4.2.1;MetaCyc: PWY-5532;Reactome: R-HSA-74259;MetaCyc: PWY-5695;MetaCyc: PWY-7179-1;MetaCyc: PWY-4202;MetaCyc: PWY-6644;MetaCyc: PWY-6611;MetaCyc: PWY-7179;Reactome: R-HSA-6798695;MetaCyc: PWY-6627;MetaCyc: PWY-6608;MetaCyc: PWY-6609;MetaCyc: PWY-6620;KEGG: 00230+2.4.2.1;KEGG: 00760+2.4.2.1;Reactome: R-HSA-74217 "Pyrimidine metabolism";"Nucleoside and nucleotide degradation (archaea)";"Purine catabolism";"Inosine 5'-phosphate degradation";"Purine deoxyribonucleosides degradation II";"Arsenate detoxification I (mammalian)";"Fluoroacetate and fluorothreonine biosynthesis";"Adenine and adenosine salvage V";"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Salinosporamide A biosynthesis";"Guanosine nucleotides degradation III";"Adenine and adenosine salvage III";"Guanine and guanosine salvage";"Purine metabolism";"Nicotinate and nicotinamide metabolism";"Purine salvage" XP_046735972.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046750969.1 1 Reactome: R-HSA-5358493 "Synthesis of diphthamide-EEF2" XP_046739778.1 4 Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257;Reactome: R-HSA-2470946 "Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin" XP_046749781.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046752073.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046753709.1 4 MetaCyc: PWY-7221;KEGG: 00230+6.3.5.2;Reactome: R-HSA-73817;KEGG: 00983+6.3.5.2 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Drug metabolism - other enzymes" XP_046750544.1 3 KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046752046.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046752983.1 3 Reactome: R-HSA-162658;Reactome: R-HSA-204005;Reactome: R-HSA-6807878 "Golgi Cisternae Pericentriolar Stack Reorganization";"COPII-mediated vesicle transport";"COPI-mediated anterograde transport" XP_046752761.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046741410.1 10 Reactome: R-HSA-167162;Reactome: R-HSA-3214847;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-674695 "RNA Polymerase II HIV Promoter Escape";"HATs acetylate histones";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events" XP_046735338.1 1 Reactome: R-HSA-380320 "Recruitment of NuMA to mitotic centrosomes" XP_046748728.1 3 Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-3108214 "DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"SUMOylation of DNA damage response and repair proteins" XP_046735829.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046748764.1 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" XP_046740320.1 27 Reactome: R-HSA-168276;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749 "NS1 Mediated Effects on Host Pathways";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"snRNP Assembly";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs" XP_046741727.1 1 Reactome: R-HSA-169911 "Regulation of Apoptosis" XP_046742016.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046752471.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046753000.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046752515.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-430039 "mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease" XP_046742194.1 1 Reactome: R-HSA-3000471 "Scavenging by Class B Receptors" XP_046745617.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046748438.1 14 MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7724;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-7601;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725 "(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)" XP_046749507.1 6 MetaCyc: PWY-6344;MetaCyc: PWY-4981;Reactome: R-HSA-8964539;MetaCyc: PWY-3341;MetaCyc: PWY-6922;KEGG: 00330+2.6.1.13 "L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)";"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)";"L-Ndelta-acetylornithine biosynthesis";"Arginine and proline metabolism" XP_046742996.1 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" XP_046740097.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046748418.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046754004.1 3 KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961;Reactome: R-HSA-196783 "Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis" XP_046740919.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046753964.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046749898.1 34 Reactome: R-HSA-1169408;Reactome: R-HSA-9639288;Reactome: R-HSA-5619107;Reactome: R-HSA-68877;Reactome: R-HSA-180746;Reactome: R-HSA-168276;Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-159227;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-5663220;Reactome: R-HSA-5578749;Reactome: R-HSA-2500257;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-141444 "ISG15 antiviral mechanism";"Amino acids regulate mTORC1";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Mitotic Prometaphase";"Nuclear import of Rev protein";"NS1 Mediated Effects on Host Pathways";"HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP independent Mature mRNA";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"RHO GTPases Activate Formins";"Transcriptional regulation by small RNAs";"Resolution of Sister Chromatid Cohesion";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"HCMV Late Events";"SUMOylation of DNA replication proteins";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046745648.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046740070.1 1 Reactome: R-HSA-1483191 "Synthesis of PC" XP_046748032.1 1 Reactome: R-HSA-1660499 "Synthesis of PIPs at the plasma membrane" XP_046751454.1 3 Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261 "Triglyceride biosynthesis";"Glycerolipid metabolism";"Glycerol degradation I" XP_046748541.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046745496.1 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" XP_046750131.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046749351.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046734498.1 12 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04150+2.7.11.1;Reactome: R-HSA-418885;Reactome: R-HSA-193648;Reactome: R-HSA-416476;Reactome: R-HSA-194840;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"G alpha (12/13) signalling events";"mTOR signaling pathway";"DCC mediated attractive signaling";"NRAGE signals death through JNK";"G alpha (q) signalling events";"Rho GTPase cycle";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046734685.1 3 Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046747443.1 9 Reactome: R-HSA-2024096;Reactome: R-HSA-3656253;Reactome: R-HSA-3560783;Reactome: R-HSA-3560801;Reactome: R-HSA-3656237;Reactome: R-HSA-975634;Reactome: R-HSA-1971475;Reactome: R-HSA-2022928;Reactome: R-HSA-4420332 "HS-GAG degradation";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective B4GALT7 causes EDS, progeroid type";"Defective B3GAT3 causes JDSSDHD";"Defective EXT2 causes exostoses 2";"Retinoid metabolism and transport";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG biosynthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1" XP_046754057.1 7 Reactome: R-HSA-3108214;Reactome: R-HSA-2173795;Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-5696400;Reactome: R-HSA-5685939;Reactome: R-HSA-110362 "SUMOylation of DNA damage response and repair proteins";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"Dual Incision in GG-NER";"HDR through MMEJ (alt-NHEJ)";"POLB-Dependent Long Patch Base Excision Repair" XP_046738735.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046750643.1 5 Reactome: R-HSA-901032;Reactome: R-HSA-381038;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346;MetaCyc: PWY-7511 "ER Quality Control Compartment (ERQC)";"XBP1(S) activates chaperone genes";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis";"Protein ubiquitination" XP_046748573.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046739497.1 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046739870.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046738445.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046753927.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046738661.1 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" XP_046736382.1 4 Reactome: R-HSA-6790901;Reactome: R-HSA-72764;Reactome: R-HSA-6782315;Reactome: R-HSA-156581 "rRNA modification in the nucleus and cytosol";"Eukaryotic Translation Termination";"tRNA modification in the nucleus and cytosol";"Methylation" XP_046743851.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046740129.1 12 Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-6804756;Reactome: R-HSA-167287;Reactome: R-HSA-167200;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167152;Reactome: R-HSA-167238 "Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Regulation of TP53 Activity through Phosphorylation";"HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of Tat-mediated HIV elongation" XP_046744547.1 24 Reactome: R-HSA-9009391;Reactome: R-HSA-418597;Reactome: R-HSA-418217;Reactome: R-HSA-392451;Reactome: R-HSA-416482;Reactome: R-HSA-432040;Reactome: R-HSA-456926;Reactome: R-HSA-400042;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-416476;Reactome: R-HSA-381676;Reactome: R-HSA-428930;Reactome: R-HSA-6814122;Reactome: R-HSA-392170;Reactome: R-HSA-392851;Reactome: R-HSA-420092;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-8964315;Reactome: R-HSA-418592;Reactome: R-HSA-500657;Reactome: R-HSA-8964616;Reactome: R-HSA-4086398 "Extra-nuclear estrogen signaling";"G alpha (z) signalling events";"G beta:gamma signalling through PLC beta";"G beta:gamma signalling through PI3Kgamma";"G alpha (12/13) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Thrombin signalling through proteinase activated receptors (PARs)";"Adrenaline,noradrenaline inhibits insulin secretion";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"G alpha (q) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Thromboxane signalling through TP receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"ADP signalling through P2Y purinoceptor 12";"Prostacyclin signalling through prostacyclin receptor";"Glucagon-type ligand receptors";"G alpha (i) signalling events";"G-protein activation";"G beta:gamma signalling through BTK";"ADP signalling through P2Y purinoceptor 1";"Presynaptic function of Kainate receptors";"G beta:gamma signalling through CDC42";"Ca2+ pathway" XP_046745998.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046743487.1 2 Reactome: R-HSA-390471;Reactome: R-HSA-1660662 "Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism" XP_046751486.1 5 Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-6798695;Reactome: R-HSA-3928662;Reactome: R-HSA-8856828 "RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"Neutrophil degranulation";"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis" XP_046747101.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046752921.1 3 Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621 "Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism" XP_046742560.1 12 Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-450408;Reactome: R-HSA-166208;Reactome: R-HSA-72662;Reactome: R-HSA-1169408;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-429947 "Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"mTORC1-mediated signalling";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"ISG15 antiviral mechanism";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Deadenylation of mRNA" XP_046753303.1 1 Reactome: R-HSA-2428928 "IRS-related events triggered by IGF1R" XP_046753326.1 7 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" XP_046751040.1 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" XP_046753092.1 13 MetaCyc: PWY-7226;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7220;KEGG: 00480+1.17.4.1;KEGG: 00230+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7222;MetaCyc: PWY-7227;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943 "Guanosine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates" XP_046748243.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-8873719 "RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation" XP_046740695.1 20 Reactome: R-HSA-6782210;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5696397;Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-110320;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-5685938;Reactome: R-HSA-5655862;Reactome: R-HSA-6782135;Reactome: R-HSA-5693616;Reactome: R-HSA-5656169;Reactome: R-HSA-5656121;Reactome: R-HSA-110312;Reactome: R-HSA-110314;Reactome: R-HSA-5685942 "Gap-filling DNA repair synthesis and ligation in TC-NER";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Dual Incision in GG-NER";"Polymerase switching";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Translesion Synthesis by POLH";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"HDR through Single Strand Annealing (SSA)";"Translesion synthesis by POLK";"Dual incision in TC-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Termination of translesion DNA synthesis";"Translesion synthesis by POLI";"Translesion synthesis by REV1";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)" XP_046740563.1 2 Reactome: R-HSA-71336;KEGG: 00710+2.7.1.14 "Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms" XP_046753335.1 1 Reactome: R-HSA-6811436 "COPI-independent Golgi-to-ER retrograde traffic" XP_046734409.1 11 MetaCyc: PWY-5123;MetaCyc: PWY-6174;MetaCyc: PWY-7524;MetaCyc: PWY-7102;MetaCyc: PWY-7391;MetaCyc: PWY-7560;MetaCyc: PWY-6383;MetaCyc: PWY-922;KEGG: 00900+5.3.3.2;Reactome: R-HSA-191273;MetaCyc: PWY-6859 "Trans, trans-farnesyl diphosphate biosynthesis";"Mevalonate pathway II (archaea)";"Mevalonate pathway III (archaea)";"Bisabolene biosynthesis (engineered)";"Isoprene biosynthesis II (engineered)";"Methylerythritol phosphate pathway II";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"All-trans-farnesol biosynthesis" XP_046743548.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046739202.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046737106.1 2 Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2 "Signaling by SCF-KIT";"T cell receptor signaling pathway" XP_046734916.1 9 Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-110314 "Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Neddylation";"DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Recognition of DNA damage by PCNA-containing replication complex" XP_046734518.1 3 Reactome: R-HSA-3214858;Reactome: R-HSA-6804760;Reactome: R-HSA-191859 "RMTs methylate histone arginines";"Regulation of TP53 Activity through Methylation";"snRNP Assembly" XP_046740474.1 6 Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" XP_046748222.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046748735.1 2 Reactome: R-HSA-456926;Reactome: R-HSA-416482 "Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (12/13) signalling events" XP_046742957.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046737694.1 19 Reactome: R-HSA-380320;MetaCyc: PWY-7197;MetaCyc: PWY-7220;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7184;MetaCyc: PWY-7176;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7222;MetaCyc: PWY-7187;MetaCyc: PWY-7224;MetaCyc: PWY-6545;Reactome: R-HSA-380270;MetaCyc: PWY-7226;MetaCyc: PWY-7210;MetaCyc: PWY-7227;MetaCyc: PWY-7198;MetaCyc: PWY-7205;MetaCyc: PWY-7221;KEGG: 00240+2.7.4.6 "Recruitment of NuMA to mitotic centrosomes";"Pyrimidine deoxyribonucleotide phosphorylation";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"UTP and CTP de novo biosynthesis";"Drug metabolism - other enzymes";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Recruitment of mitotic centrosome proteins and complexes";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"CMP phosphorylation";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine metabolism" XP_046743898.1 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" XP_046746220.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046754002.1 3 KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961;Reactome: R-HSA-196783 "Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis" XP_046743282.1 6 Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" XP_046751974.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046734337.1 16 Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-176407;Reactome: R-HSA-176409;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-174048 "Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Cyclin B" XP_046751422.1 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" XP_046740285.1 7 KEGG: 00550+2.7.8.13;MetaCyc: PWY-6470;MetaCyc: PWY-6471;KEGG: 00510+2.7.8.15;MetaCyc: PWY-5265;Reactome: R-HSA-4549356;Reactome: R-HSA-446193 "Peptidoglycan biosynthesis";"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"N-Glycan biosynthesis";"Peptidoglycan biosynthesis II (staphylococci)";"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" XP_046743332.1 1 Reactome: R-HSA-6785631 "ERBB2 Regulates Cell Motility" XP_046752448.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046739628.1 24 Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-6807878 "Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Cilium Assembly";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"COPI-mediated anterograde transport" XP_046750926.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046753037.1 4 MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48 "Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism";"Pyrimidine salvage";"Drug metabolism - other enzymes" XP_046743005.1 14 Reactome: R-HSA-6782210;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-5655862;Reactome: R-HSA-5696397;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-5656121;Reactome: R-HSA-69091;Reactome: R-HSA-110320;Reactome: R-HSA-110314;Reactome: R-HSA-110312;Reactome: R-HSA-5685942 "Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Translesion synthesis by POLI";"Polymerase switching";"Translesion Synthesis by POLH";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)" XP_046737396.1 7 Reactome: R-HSA-1655829;Reactome: R-HSA-5578749;Reactome: R-HSA-6784531;Reactome: R-HSA-180746;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-203927 "Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Transcriptional regulation by small RNAs";"tRNA processing in the nucleus";"Nuclear import of Rev protein";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"MicroRNA (miRNA) biogenesis" XP_046743933.1 12 KEGG: 00040+2.7.7.9;MetaCyc: PWY-7238;KEGG: 00052+2.7.7.9;MetaCyc: PWY-6527;Reactome: R-HSA-3322077;Reactome: R-HSA-173599;KEGG: 00520+2.7.7.9;MetaCyc: PWY-3801;KEGG: 00561+2.7.7.9;MetaCyc: PWY-7817;MetaCyc: PWY-7343;KEGG: 00500+2.7.7.9 "Pentose and glucuronate interconversions";"Sucrose biosynthesis II";"Galactose metabolism";"Stachyose degradation";"Glycogen synthesis";"Formation of the active cofactor, UDP-glucuronate";"Amino sugar and nucleotide sugar metabolism";"Sucrose degradation II (sucrose synthase)";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"UDP-alpha-D-glucose biosynthesis I";"Starch and sucrose metabolism" XP_046744174.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection" XP_046752437.1 5 MetaCyc: PWY-5189;Reactome: R-HSA-6798695;KEGG: 00860+4.2.1.24;Reactome: R-HSA-189451;MetaCyc: PWY-5188 "Tetrapyrrole biosynthesis II (from glycine)";"Neutrophil degranulation";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)" XP_046748343.1 5 KEGG: 00230+6.3.5.3;MetaCyc: PWY-6121;Reactome: R-HSA-73817;MetaCyc: PWY-6277;MetaCyc: PWY-6122 "Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II" XP_046740387.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046734806.1 2 Reactome: R-HSA-74217;KEGG: 00230+1.7.1.7 "Purine salvage";"Purine metabolism" XP_046749366.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046747726.1 1 Reactome: R-HSA-5368286 "Mitochondrial translation initiation" XP_046746748.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046748261.1 3 Reactome: R-HSA-445355;Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2 "Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase";"Purine metabolism" XP_046753769.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046750038.1 2 Reactome: R-HSA-69273;Reactome: R-HSA-8862803 "Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" XP_046736081.1 1 Reactome: R-HSA-5389840 "Mitochondrial translation elongation" XP_046753496.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046747851.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046745411.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" XP_046736470.1 8 MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;Reactome: R-HSA-5083629;Reactome: R-HSA-5083633;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922;Reactome: R-HSA-5173105 "Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"O-linked glycosylation" XP_046750825.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046745837.1 6 MetaCyc: PWY-4261;Reactome: R-HSA-1483166;Reactome: R-HSA-163560;MetaCyc: PWY-6952;KEGG: 00564+1.1.5.3;MetaCyc: PWY-6118 "Glycerol degradation I";"Synthesis of PA";"Triglyceride catabolism";"Glycerophosphodiester degradation";"Glycerophospholipid metabolism";"Glycerol-3-phosphate shuttle" XP_046740566.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046736128.1 5 Reactome: R-HSA-72187;Reactome: R-HSA-72165;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "mRNA 3'-end processing";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046743288.1 3 KEGG: 00480+4.3.2.7;Reactome: R-HSA-174403;MetaCyc: PWY-7942 "Glutathione metabolism";"Glutathione synthesis and recycling";"5-oxo-L-proline metabolism" XP_046739554.1 2 Reactome: R-HSA-6784531;Reactome: R-HSA-6791226 "tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046743275.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884 "Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I" XP_046752445.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046735462.1 3 Reactome: R-HSA-749476;Reactome: R-HSA-6807505;Reactome: R-HSA-76071 "RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" XP_046748429.1 3 Reactome: R-HSA-2022854;Reactome: R-HSA-5083627;Reactome: R-HSA-5173105 "Keratan sulfate biosynthesis";"Defective LARGE causes MDDGA6 and MDDGB6";"O-linked glycosylation" XP_046745822.1 2 MetaCyc: PWY-6981;KEGG: 00520+2.4.1.16 "Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism" XP_046748972.1 3 MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783 "Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis" XP_046735465.1 2 Reactome: R-HSA-71403;Reactome: R-HSA-611105 "Citric acid cycle (TCA cycle)";"Respiratory electron transport" XP_046752535.1 2 KEGG: 00970+6.1.1.2;Reactome: R-HSA-379726 "Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" XP_046740991.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046750871.1 3 Reactome: R-HSA-6811438;Reactome: R-HSA-8876198;Reactome: R-HSA-6811440 "Intra-Golgi traffic";"RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network" XP_046741558.1 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" XP_046738085.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046736587.1 3 Reactome: R-HSA-189451;KEGG: 00860+1.3.3.4;MetaCyc: PWY-7159 "Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)" XP_046744210.1 2 Reactome: R-HSA-9603798;Reactome: R-HSA-1369062 "Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis" XP_046741334.1 10 Reactome: R-HSA-8936459;Reactome: R-HSA-9022699;Reactome: R-HSA-3899300;Reactome: R-HSA-9022538;Reactome: R-HSA-9022702;Reactome: R-HSA-400206;Reactome: R-HSA-9615017;Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-9022692 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"MECP2 regulates neuronal receptors and channels";"SUMOylation of transcription cofactors";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates transcription of neuronal ligands";"Regulation of lipid metabolism by PPARalpha";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"Regulation of MECP2 expression and activity" XP_046741395.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84 "Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis" XP_046745760.1 3 MetaCyc: PWY-6482;Reactome: R-HSA-5358493;MetaCyc: PWY-7546 "Diphthamide biosynthesis I (archaea)";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)" XP_046735472.1 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" XP_046754045.1 1 Reactome: R-HSA-2022928 "HS-GAG biosynthesis" XP_046751731.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046753628.1 1 Reactome: R-HSA-186797 "Signaling by PDGF" XP_046746140.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046749877.1 1 KEGG: 00480+3.4.11.1 "Glutathione metabolism" XP_046749779.1 2 Reactome: R-HSA-110320;Reactome: R-HSA-983168 "Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046742897.1 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" XP_046748433.1 3 Reactome: R-HSA-5083627;Reactome: R-HSA-2022854;Reactome: R-HSA-5173105 "Defective LARGE causes MDDGA6 and MDDGB6";"Keratan sulfate biosynthesis";"O-linked glycosylation" XP_046742550.1 13 MetaCyc: PWY-6728;MetaCyc: PWY-5537;Reactome: R-HSA-71403;MetaCyc: PWY-6969;MetaCyc: PWY-5392;MetaCyc: PWY-5690;KEGG: 00660+6.2.1.5;MetaCyc: PWY-7384;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913;KEGG: 00720+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538 "Methylaspartate cycle";"Pyruvate fermentation to acetate V";"Citric acid cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"C5-Branched dibasic acid metabolism";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI" XP_046745611.1 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046737049.1 2 Reactome: R-HSA-373080;Reactome: R-HSA-3238698 "Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking" XP_046749306.1 3 Reactome: R-HSA-77588;Reactome: R-HSA-73856;Reactome: R-HSA-159230 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination";"Transport of the SLBP Dependant Mature mRNA" XP_046739757.1 4 Reactome: R-HSA-1170546;Reactome: R-HSA-982772;Reactome: R-HSA-2586552;Reactome: R-HSA-983231 "Prolactin receptor signaling";"Growth hormone receptor signaling";"Signaling by Leptin";"Factors involved in megakaryocyte development and platelet production" XP_046741915.1 1 KEGG: 00860+4.4.1.17 "Porphyrin and chlorophyll metabolism" XP_046739185.1 7 Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-1538133;Reactome: R-HSA-1362300;Reactome: R-HSA-69656;Reactome: R-HSA-156711;Reactome: R-HSA-69202 "G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"G0 and Early G1";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin A:Cdk2-associated events at S phase entry";"Polo-like kinase mediated events";"Cyclin E associated events during G1/S transition" XP_046736217.1 2 Reactome: R-HSA-72702;Reactome: R-HSA-72706 "Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046744958.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046736270.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046745204.1 2 Reactome: R-HSA-2514853;Reactome: R-HSA-2299718 "Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes" XP_046753661.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046745377.1 11 Reactome: R-HSA-2426168;Reactome: R-HSA-400206;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-1368082;Reactome: R-HSA-2151201;Reactome: R-HSA-1368108;Reactome: R-HSA-3214858;Reactome: R-HSA-6804114;Reactome: R-HSA-400253;Reactome: R-HSA-381340 "Activation of gene expression by SREBF (SREBP)";"Regulation of lipid metabolism by PPARalpha";"Estrogen-dependent gene expression";"PPARA activates gene expression";"RORA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"RMTs methylate histone arginines";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation" XP_046742282.1 6 MetaCyc: PWY-2221;MetaCyc: PWY-5530;MetaCyc: PWY-7165;KEGG: 00030+3.1.1.17;KEGG: 00930+3.1.1.17;KEGG: 00053+3.1.1.17 "Entner-Doudoroff pathway III (semi-phosphorylative)";"Sorbitol biosynthesis II";"L-ascorbate biosynthesis VI (engineered pathway)";"Pentose phosphate pathway";"Caprolactam degradation";"Ascorbate and aldarate metabolism" XP_046734291.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046746505.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782 "Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis" XP_046735447.1 1 Reactome: R-HSA-5617472 "Activation of anterior HOX genes in hindbrain development during early embryogenesis" XP_046751998.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046736322.1 2 Reactome: R-HSA-1483166;Reactome: R-HSA-1483148 "Synthesis of PA";"Synthesis of PG" XP_046743340.1 5 KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00380+1.2.4.2;MetaCyc: PWY-5084;Reactome: R-HSA-389661 "Lysine degradation";"Citrate cycle (TCA cycle)";"Tryptophan metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation" XP_046751617.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046750121.1 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" XP_046746588.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046746240.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046749459.1 8 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Activation of RAC1";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046746651.1 7 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046753365.1 19 Reactome: R-HSA-5673001;Reactome: R-HSA-936837;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-9649948;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-438066;Reactome: R-HSA-5673000;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5576892;Reactome: R-HSA-442982;Reactome: R-HSA-399719 "RAF/MAP kinase cascade";"Ion transport by P-type ATPases";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Signaling downstream of RAS mutants";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"RAF activation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"Phase 0 - rapid depolarisation";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors" XP_046742230.1 6 MetaCyc: PWY-5744;MetaCyc: PWY-4381;MetaCyc: PWY-5743;Reactome: R-HSA-196780;MetaCyc: PWY-6722;MetaCyc: PWY-5789 "Glyoxylate assimilation";"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate cycle";"Biotin transport and metabolism";"Candicidin biosynthesis";"3-hydroxypropanoate/4-hydroxybutanate cycle" XP_046750505.1 1 Reactome: R-HSA-1362409 "Mitochondrial iron-sulfur cluster biogenesis" XP_046742944.1 13 Reactome: R-HSA-2024101;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-7883;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-6902 "CS/DS degradation";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Chitin degradation III (Serratia)";"Anhydromuropeptides recycling II";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation";"Chitin degradation II (Vibrio)" XP_046741388.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046741024.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046739444.1 27 Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-3108214;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-9609690 "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"snRNP Assembly";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events" XP_046753001.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046741376.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046741082.1 2 Reactome: R-HSA-2022377;Reactome: R-HSA-6798695 "Metabolism of Angiotensinogen to Angiotensins";"Neutrophil degranulation" XP_046751526.1 13 Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" XP_046746536.1 4 Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3 "Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism" XP_046739694.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" XP_046746669.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046742863.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046752288.1 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046747556.1 27 Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-4570464 "SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins" XP_046741030.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046736691.1 4 Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" XP_046746957.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046748036.1 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" XP_046747106.1 1 Reactome: R-HSA-399956 "CRMPs in Sema3A signaling" XP_046744071.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046746692.1 5 Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-1222556 "Transferrin endocytosis and recycling";"Ion channel transport";"Amino acids regulate mTORC1";"Insulin receptor recycling";"ROS and RNS production in phagocytes" XP_046740375.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046739587.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046747278.1 6 MetaCyc: PWY-7817;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039 "Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule" XP_046750987.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046750728.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046749384.1 7 Reactome: R-HSA-1660516;Reactome: R-HSA-1660514;Reactome: R-HSA-1660499;MetaCyc: PWY-6352;KEGG: 00562+2.7.1.67;MetaCyc: PWY-6351;KEGG: 04070+2.7.1.67 "Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the plasma membrane";"3-phosphoinositide biosynthesis";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system" XP_046743845.1 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" XP_046737755.1 7 Reactome: R-HSA-4641258;Reactome: R-HSA-4086400;Reactome: R-HSA-201688;Reactome: R-HSA-5663220;Reactome: R-HSA-5368598;Reactome: R-HSA-201681;Reactome: R-HSA-4641262 "Degradation of DVL";"PCP/CE pathway";"WNT mediated activation of DVL";"RHO GTPases Activate Formins";"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"TCF dependent signaling in response to WNT";"Disassembly of the destruction complex and recruitment of AXIN to the membrane" XP_046739617.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046749878.1 1 KEGG: 00480+3.4.11.1 "Glutathione metabolism" XP_046751147.1 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" XP_046743303.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046735490.1 4 Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway" XP_046742722.1 6 MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463 "Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis" XP_046746679.1 22 MetaCyc: PWY-7725;MetaCyc: PWY-5353;MetaCyc: PWY-7726;MetaCyc: PWY-7601;MetaCyc: PWY-6958;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7049;MetaCyc: PWY-6598;MetaCyc: PWY-7592;Reactome: R-HSA-75876;MetaCyc: PWY-7728;MetaCyc: PWY-7619;MetaCyc: PWY-7724;MetaCyc: PWY-7727;MetaCyc: PWY-7053;MetaCyc: PWY-7606;MetaCyc: PWY-7035;KEGG: 00062+4.2.1.134 "Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Sciadonate biosynthesis";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation" XP_046749346.1 1 Reactome: R-HSA-71403 "Citric acid cycle (TCA cycle)" XP_046740047.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046738290.1 42 Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-110330;Reactome: R-HSA-9609690;Reactome: R-HSA-69473;Reactome: R-HSA-5625886;Reactome: R-HSA-201722;Reactome: R-HSA-3214841;Reactome: R-HSA-73728;Reactome: R-HSA-212300;Reactome: R-HSA-9018519;Reactome: R-HSA-171306;Reactome: R-HSA-2299718;Reactome: R-HSA-110328;Reactome: R-HSA-5334118;Reactome: R-HSA-110329;Reactome: R-HSA-110331;Reactome: R-HSA-3214847;Reactome: R-HSA-5693571;Reactome: R-HSA-3214815;Reactome: R-HSA-9616222;Reactome: R-HSA-977225;Reactome: R-HSA-8939236;Reactome: R-HSA-606279;Reactome: R-HSA-9610379;Reactome: R-HSA-3214858;Reactome: R-HSA-8936459;Reactome: R-HSA-427359;Reactome: R-HSA-1221632;Reactome: R-HSA-2559586;Reactome: R-HSA-1912408;Reactome: R-HSA-5578749;Reactome: R-HSA-2559580;Reactome: R-HSA-2559582;Reactome: R-HSA-5617472;Reactome: R-HSA-3214842;Reactome: R-HSA-427413;Reactome: R-HSA-73772;Reactome: R-HSA-4551638;Reactome: R-HSA-5693565;Reactome: R-HSA-5250924;Reactome: R-HSA-427389 "Processing of DNA double-strand break ends";"Meiotic recombination";"Recognition and association of DNA glycosylase with site containing an affected purine";"HCMV Early Events";"G2/M DNA damage checkpoint";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines";"RNA Polymerase I Promoter Opening";"PRC2 methylates histones and DNA";"Estrogen-dependent gene expression";"Packaging Of Telomere Ends";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"DNA methylation";"Cleavage of the damaged pyrimidine";"Cleavage of the damaged purine";"HATs acetylate histones";"Nonhomologous End-Joining (NHEJ)";"HDACs deacetylate histones";"Transcriptional regulation of granulopoiesis";"Amyloid fiber formation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere";"HCMV Late Events";"RMTs methylate histone arginines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SIRT1 negatively regulates rRNA expression";"Meiotic synapsis";"DNA Damage/Telomere Stress Induced Senescence";"Pre-NOTCH Transcription and Translation";"Transcriptional regulation by small RNAs";"Oxidative Stress Induced Senescence";"Senescence-Associated Secretory Phenotype (SASP)";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HDMs demethylate histones";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"SUMOylation of chromatin organization proteins";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" XP_046747505.1 2 Reactome: R-HSA-975577;Reactome: R-HSA-2022854 "N-Glycan antennae elongation";"Keratan sulfate biosynthesis" XP_046741366.1 7 MetaCyc: PWY-7221;Reactome: R-HSA-73817;Reactome: R-HSA-6798695;KEGG: 00230+1.1.1.205;KEGG: 00983+1.1.1.205;MetaCyc: PWY-6596;MetaCyc: PWY-5695 "Guanosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Neutrophil degranulation";"Purine metabolism";"Drug metabolism - other enzymes";"Adenosine nucleotides degradation I";"Inosine 5'-phosphate degradation" XP_046741029.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046745779.1 7 Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1855204;Reactome: R-HSA-8856828;Reactome: R-HSA-1660499;MetaCyc: PWY-6368 "Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol";"Clathrin-mediated endocytosis";"Synthesis of PIPs at the plasma membrane";"3-phosphoinositide degradation" XP_046752348.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046734870.1 7 KEGG: 00790+1.14.16.1;KEGG: 00400+1.14.16.1;MetaCyc: PWY-6134;Reactome: R-HSA-8964208;KEGG: 00360+1.14.16.1;Reactome: R-HSA-2160456;MetaCyc: PWY-7158 "Folate biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"L-tyrosine biosynthesis IV";"Phenylalanine metabolism";"Phenylalanine metabolism";"Phenylketonuria";"L-phenylalanine degradation V" XP_046750773.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046735488.1 9 Reactome: R-HSA-3656532;Reactome: R-HSA-5689603;Reactome: R-HSA-2173788;Reactome: R-HSA-3656535;Reactome: R-HSA-2173791;Reactome: R-HSA-3645790;Reactome: R-HSA-3304356;Reactome: R-HSA-2173789;Reactome: R-HSA-3642279 "TGFBR1 KD Mutants in Cancer";"UCH proteinases";"Downregulation of TGF-beta receptor signaling";"TGFBR1 LBD Mutants in Cancer";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGFBR2 Kinase Domain Mutants in Cancer";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGF-beta receptor signaling activates SMADs";"TGFBR2 MSI Frameshift Mutants in Cancer" XP_046744445.1 7 Reactome: R-HSA-5674400;Reactome: R-HSA-198323;Reactome: R-HSA-8854214;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-165181;Reactome: R-HSA-1632852 "Constitutive Signaling by AKT1 E17K in Cancer";"AKT phosphorylates targets in the cytosol";"TBC/RABGAPs";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Inhibition of TSC complex formation by PKB";"Macroautophagy" XP_046748385.1 27 Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-159230;Reactome: R-HSA-1169408;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-159227;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-168271 "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"HCMV Late Events";"SUMOylation of DNA replication proteins";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"Transport of Ribonucleoproteins into the Host Nucleus" XP_046741186.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046750780.1 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" XP_046751844.1 1 Reactome: R-HSA-9633012 "Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046751494.1 2 KEGG: 00230+4.6.1.1;Reactome: R-HSA-196819 "Purine metabolism";"Vitamin B1 (thiamin) metabolism" XP_046734526.1 2 Reactome: R-HSA-6783984;Reactome: R-HSA-389661 "Glycine degradation";"Glyoxylate metabolism and glycine degradation" XP_046749196.1 13 Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-6791226 "Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046750092.1 5 Reactome: R-HSA-450513;Reactome: R-HSA-430039;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-450385 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" XP_046749441.1 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" XP_046745712.1 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" XP_046735544.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046748781.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046748440.1 14 MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6598;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601 "(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)" XP_046738460.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046737575.1 2 Reactome: R-HSA-1660662;Reactome: R-HSA-390471 "Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis" XP_046736458.1 1 Reactome: R-HSA-112126 "ALKBH3 mediated reversal of alkylation damage" XP_046751963.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046745295.1 33 Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-2500257;Reactome: R-HSA-168271;Reactome: R-HSA-141444;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-9609690;Reactome: R-HSA-168276;Reactome: R-HSA-191859;Reactome: R-HSA-159227;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-3108214;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-5619107 "Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Resolution of Sister Chromatid Cohesion";"Transport of Ribonucleoproteins into the Host Nucleus";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"HCMV Late Events";"SUMOylation of DNA replication proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Early Events";"NS1 Mediated Effects on Host Pathways";"snRNP Assembly";"Transport of the SLBP independent Mature mRNA";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA damage response and repair proteins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"Nuclear import of Rev protein";"Mitotic Prometaphase";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)" XP_046748724.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046739343.1 4 Reactome: R-HSA-5678895;Reactome: R-HSA-5358346;Reactome: R-HSA-382556;Reactome: R-HSA-5362768 "Defective CFTR causes cystic fibrosis";"Hedgehog ligand biogenesis";"ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD" XP_046735635.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046747161.1 5 Reactome: R-HSA-2395516;Reactome: R-HSA-1362409;Reactome: R-HSA-5579026;Reactome: R-HSA-196108;Reactome: R-HSA-211976 "Electron transport from NADPH to Ferredoxin";"Mitochondrial iron-sulfur cluster biogenesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Pregnenolone biosynthesis";"Endogenous sterols" XP_046735301.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046754059.1 6 Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex" XP_046747261.1 2 Reactome: R-HSA-9033241;Reactome: R-HSA-8866654 "Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046750318.1 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046738970.1 14 MetaCyc: PWY-5497;MetaCyc: PWY-6606;MetaCyc: PWY-6608;KEGG: 00232+1.17.3.2;KEGG: 00230+1.17.1.4+1.17.3.2;MetaCyc: PWY-5695;MetaCyc: PWY-6607;Reactome: R-HSA-74259;Reactome: R-HSA-8851680;MetaCyc: PWY-6999;KEGG: 00230+1.17.1.4;MetaCyc: PWY-6538;MetaCyc: PWY-6596;KEGG: 00983+1.17.3.2 "Purine nucleobases degradation II (anaerobic)";"Guanosine nucleotides degradation II";"Guanosine nucleotides degradation III";"Caffeine metabolism";"Purine metabolism";"Inosine 5'-phosphate degradation";"Guanosine nucleotides degradation I";"Purine catabolism";"Butyrophilin (BTN) family interactions";"Theophylline degradation";"Purine metabolism";"Caffeine degradation III (bacteria, via demethylation)";"Adenosine nucleotides degradation I";"Drug metabolism - other enzymes" XP_046751103.1 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" XP_046745819.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046735190.1 12 KEGG: 00620+6.2.1.1;MetaCyc: PWY-5108;MetaCyc: PWY-6672;KEGG: 00630+6.2.1.1;KEGG: 00010+6.2.1.1;MetaCyc: PWY-5132;MetaCyc: PWY-7118;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5133;KEGG: 00640+6.2.1.1;KEGG: 00720+6.2.1.1;MetaCyc: PWY-7857 "Pyruvate metabolism";"L-isoleucine biosynthesis V";"Cis-genanyl-coa degradation";"Glyoxylate and dicarboxylate metabolism";"Glycolysis / Gluconeogenesis";"Lupulone and humulone biosynthesis";"Chitin degradation to ethanol";"Methane metabolism";"Colupulone and cohumulone biosynthesis";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Adlupulone and adhumulone biosynthesis" XP_046746530.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" XP_046743327.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046753010.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046748690.1 5 MetaCyc: PWY-6855;Reactome: R-HSA-189085;MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14 "Chitin degradation I (archaea)";"Digestion of dietary carbohydrate";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism" XP_046740208.1 2 Reactome: R-HSA-446205;KEGG: 00500+2.4.1.15 "Synthesis of GDP-mannose";"Starch and sucrose metabolism" XP_046736765.1 3 KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway" XP_046752593.1 9 MetaCyc: PWY-7039;MetaCyc: PWY-6351;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11;Reactome: R-HSA-1855204;Reactome: R-HSA-112043;Reactome: R-HSA-416476;MetaCyc: PWY-6367;MetaCyc: PWY-8052 "Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol";"PLC beta mediated events";"G alpha (q) signalling events";"D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis" XP_046736553.1 1 Reactome: R-HSA-379726 "Mitochondrial tRNA aminoacylation" XP_046751658.1 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" XP_046744551.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046752303.1 13 Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" XP_046747511.1 3 Reactome: R-HSA-76071;Reactome: R-HSA-6807505;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Abortive And Retractive Initiation" XP_046735908.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046746893.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046739676.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095 "Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins" XP_046739500.1 1 Reactome: R-HSA-3000471 "Scavenging by Class B Receptors" XP_046734845.1 2 KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383 "Other glycan degradation";"Lysosomal oligosaccharide catabolism" XP_046752444.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046753954.1 4 MetaCyc: PWY-7437;Reactome: R-HSA-3214847;Reactome: R-HSA-5689603;KEGG: 00514+2.4.1.255 "Protein O-[N-acetyl]-glucosylation";"HATs acetylate histones";"UCH proteinases";"Other types of O-glycan biosynthesis" XP_046747491.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046750171.1 1 Reactome: R-HSA-70171 "Glycolysis" XP_046750896.1 3 MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-1358803 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Downregulation of ERBB2:ERBB3 signaling" XP_046752357.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046747572.1 2 Reactome: R-HSA-749476;Reactome: R-HSA-73980 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination" XP_046743304.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046743437.1 7 Reactome: R-HSA-373753;Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-6798695;Reactome: R-HSA-264870;Reactome: R-HSA-5673001;Reactome: R-HSA-375165 "Nephrin family interactions";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Neutrophil degranulation";"Caspase-mediated cleavage of cytoskeletal proteins";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth" XP_046738821.1 6 Reactome: R-HSA-8948751;Reactome: R-HSA-8939902;Reactome: R-HSA-8863795;Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-2173788 "Regulation of PTEN stability and activity";"Regulation of RUNX2 expression and activity";"Downregulation of ERBB2 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Downregulation of TGF-beta receptor signaling" XP_046751164.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase" XP_046740998.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046735117.1 2 MetaCyc: PWY-6829;Reactome: R-HSA-6782315 "Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol" XP_046740918.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046739828.1 6 Reactome: R-HSA-389957;Reactome: R-HSA-5620922;Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-390471 "Prefoldin mediated transfer of substrate to CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis" XP_046753875.1 4 Reactome: R-HSA-6798163;MetaCyc: PWY-3722;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-7494 "Choline catabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Glycine, serine and threonine metabolism";"Choline degradation IV" XP_046752888.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046749901.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046742139.1 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" XP_046735798.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046744014.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046748720.1 7 Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518 "Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2" XP_046743693.1 6 Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046738782.1 3 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6811440 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network" XP_046735675.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046751535.1 1 Reactome: R-HSA-191859 "snRNP Assembly" XP_046739329.1 4 Reactome: R-HSA-8866427;Reactome: R-HSA-983168;Reactome: R-HSA-9031525;MetaCyc: PWY-7511 "VLDLR internalisation and degradation";"Antigen processing: Ubiquitination & Proteasome degradation";"NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake";"Protein ubiquitination" XP_046740203.1 12 KEGG: 00270+4.4.1.13;MetaCyc: PWY-6309;KEGG: 00380+2.6.1.7;MetaCyc: PWY-601;KEGG: 00450+4.4.1.13;MetaCyc: PWY-6842;Reactome: R-HSA-71240;MetaCyc: PWY-7901;MetaCyc: PWY-801;MetaCyc: PWY-2821;MetaCyc: PWY-6936;MetaCyc: PWY-1187 "Cysteine and methionine metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Tryptophan metabolism";"Glucosinolate biosynthesis from tryptophan";"Selenocompound metabolism";"Glutathione-mediated detoxification II";"Tryptophan catabolism";"Glucosinolate biosynthesis from tyrosine";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from phenylalanine";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from homomethionine" XP_046745202.1 56 Reactome: R-HSA-1236974;Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-75815;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-4641258;Reactome: R-HSA-180585;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-983168;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-9010553;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-8939902;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5689880;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176 "ER-Phagosome pathway";"Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Ubiquitin-dependent degradation of Cyclin D";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"Degradation of DVL";"Vif-mediated degradation of APOBEC3G";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of expression of SLITs and ROBOs";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Regulation of RUNX2 expression and activity";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Ub-specific processing proteases";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" XP_046736985.1 2 Reactome: R-HSA-375276;Reactome: R-HSA-418594 "Peptide ligand-binding receptors";"G alpha (i) signalling events" XP_046736337.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046747426.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046746197.1 3 Reactome: R-HSA-6798695;Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046740915.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046741710.1 3 Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648 "Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK" XP_046748958.1 1 Reactome: R-HSA-2564830 "Cytosolic iron-sulfur cluster assembly" XP_046741146.1 1 Reactome: R-HSA-606279 "Deposition of new CENPA-containing nucleosomes at the centromere" XP_046736964.1 16 Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649 "Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation" XP_046748119.1 2 Reactome: R-HSA-8854518;Reactome: R-HSA-2160916 "AURKA Activation by TPX2";"Hyaluronan uptake and degradation" XP_046748946.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046749883.1 2 Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" XP_046745423.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046750791.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046752758.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046753307.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046734083.1 1 Reactome: R-HSA-416476 "G alpha (q) signalling events" XP_046747713.1 3 Reactome: R-HSA-6807004;Reactome: R-HSA-202427;Reactome: R-HSA-6798695 "Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation" XP_046751102.1 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" XP_046754006.1 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" XP_046736292.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046738277.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046736349.1 4 Reactome: R-HSA-428540;Reactome: R-HSA-373753;Reactome: R-HSA-186763;Reactome: R-HSA-4420097 "Activation of RAC1";"Nephrin family interactions";"Downstream signal transduction";"VEGFA-VEGFR2 Pathway" XP_046744788.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046748757.1 15 Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-2559585;Reactome: R-HSA-5687128;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-8934593;Reactome: R-HSA-5628897;Reactome: R-HSA-9029569;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459 "Ca2+ pathway";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"Oncogene Induced Senescence";"MAPK6/MAPK4 signaling";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Regulation of RUNX1 Expression and Activity";"TP53 Regulates Metabolic Genes";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046749570.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046749573.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046737430.1 8 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-975957;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046747652.1 3 Reactome: R-HSA-4724325;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.265 "Defective ALG8 causes ALG8-CDG (CDG-1h)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis" XP_046750403.1 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" XP_046742543.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046745959.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046743268.1 6 KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463 "Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis" XP_046738897.1 14 Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-5620924;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-1632852;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Intraflagellar transport";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"Macroautophagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)" XP_046751807.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-400253 "Transcriptional activation of mitochondrial biogenesis";"Circadian Clock" XP_046741098.1 2 Reactome: R-HSA-1237112;KEGG: 00270+3.1.3.77 "Methionine salvage pathway";"Cysteine and methionine metabolism" XP_046747423.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046749478.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046751030.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046740666.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046734389.1 5 MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6317;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821 "Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"D-galactose detoxification" XP_046743086.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046737813.1 1 Reactome: R-HSA-442660 "Na+/Cl- dependent neurotransmitter transporters" XP_046749353.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046753850.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046743462.1 13 Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" XP_046744442.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046748431.1 3 Reactome: R-HSA-5083627;Reactome: R-HSA-2022854;Reactome: R-HSA-5173105 "Defective LARGE causes MDDGA6 and MDDGB6";"Keratan sulfate biosynthesis";"O-linked glycosylation" XP_046747921.1 26 Reactome: R-HSA-918233;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-3899300;Reactome: R-HSA-1368082;Reactome: R-HSA-3214847;Reactome: R-HSA-1234158;Reactome: R-HSA-9013508;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-9013695;Reactome: R-HSA-5617472;Reactome: R-HSA-9614657;Reactome: R-HSA-2122947;Reactome: R-HSA-5621575;Reactome: R-HSA-3371568;Reactome: R-HSA-2894862;Reactome: R-HSA-201722;Reactome: R-HSA-2644606;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-933541;Reactome: R-HSA-9617629;Reactome: R-HSA-8941856;Reactome: R-HSA-3134973;Reactome: R-HSA-8866907 "TRAF3-dependent IRF activation pathway";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"SUMOylation of transcription cofactors";"RORA activates gene expression";"HATs acetylate histones";"Regulation of gene expression by Hypoxia-inducible Factor";"NOTCH3 Intracellular Domain Regulates Transcription";"PPARA activates gene expression";"Estrogen-dependent gene expression";"NOTCH4 Intracellular Domain Regulates Transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"FOXO-mediated transcription of cell death genes";"NOTCH1 Intracellular Domain Regulates Transcription";"CD209 (DC-SIGN) signaling";"Attenuation phase";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Formation of the beta-catenin:TCF transactivating complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"TRAF6 mediated IRF7 activation";"Regulation of FOXO transcriptional activity by acetylation";"RUNX3 regulates NOTCH signaling";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Activation of the TFAP2 (AP-2) family of transcription factors" XP_046736161.1 6 MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463 "Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis" XP_046738978.1 11 Reactome: R-HSA-5693616;Reactome: R-HSA-69166;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-174437;Reactome: R-HSA-5693554;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938 "Presynaptic phase of homologous DNA pairing and strand exchange";"Removal of the Flap Intermediate";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Removal of the Flap Intermediate from the C-strand";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)" XP_046753196.1 5 Reactome: R-HSA-446210;MetaCyc: PWY-6749;MetaCyc: PWY-8013;KEGG: 00250+2.6.1.16;KEGG: 00520+2.6.1.16 "Synthesis of UDP-N-acetyl-glucosamine";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Amino sugar and nucleotide sugar metabolism" XP_046740209.1 2 Reactome: R-HSA-446205;KEGG: 00500+2.4.1.15 "Synthesis of GDP-mannose";"Starch and sucrose metabolism" XP_046743850.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046738408.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046753819.1 5 Reactome: R-HSA-450321;Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2559580;Reactome: R-HSA-2871796 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"mTOR signaling pathway";"Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation" XP_046752381.1 3 Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300 "SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors" XP_046737415.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression" XP_046747532.1 3 Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" XP_046746670.1 5 Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-390450;Reactome: R-HSA-6814122;Reactome: R-HSA-389957 "Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC" XP_046753456.1 16 Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957 "Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046750665.1 4 Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-3214815 "Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones" XP_046749971.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046738135.1 8 Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-381676;Reactome: R-HSA-983231;Reactome: R-HSA-163615;Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-180024 "PKA activation in glucagon signalling";"Hedgehog 'off' state";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Factors involved in megakaryocyte development and platelet production";"PKA activation";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"DARPP-32 events" XP_046738813.1 2 Reactome: R-HSA-5689880;Reactome: R-HSA-5689896 "Ub-specific processing proteases";"Ovarian tumor domain proteases" XP_046750510.1 1 Reactome: R-HSA-203754 "NOSIP mediated eNOS trafficking" XP_046741944.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046743692.1 6 Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" XP_046744172.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046742224.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046741057.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046744307.1 12 Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878 "Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport" XP_046739224.1 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" XP_046754099.1 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" XP_046736940.1 6 Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" XP_046742750.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046749987.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046737632.1 9 Reactome: R-HSA-400206;Reactome: R-HSA-191859;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-1368108 "Regulation of lipid metabolism by PPARalpha";"snRNP Assembly";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"BMAL1:CLOCK,NPAS2 activates circadian gene expression" XP_046735053.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046742699.1 4 Reactome: R-HSA-389661;MetaCyc: PWY-6987;MetaCyc: PWY-7382;KEGG: 00785+2.3.1.181 "Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism" XP_046753622.1 13 Reactome: R-HSA-445989;Reactome: R-HSA-450321;Reactome: R-HSA-975163;Reactome: R-HSA-5607764;Reactome: R-HSA-9020702;Reactome: R-HSA-9014325;Reactome: R-HSA-2871837;Reactome: R-HSA-937042;Reactome: R-HSA-9645460;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-450302 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"CLEC7A (Dectin-1) signaling";"Interleukin-1 signaling";"TICAM1,TRAF6-dependent induction of TAK1 complex";"FCERI mediated NF-kB activation";"IRAK2 mediated activation of TAK1 complex";"Alpha-protein kinase 1 signaling pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"activated TAK1 mediates p38 MAPK activation" XP_046747242.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046743701.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046737959.1 5 Reactome: R-HSA-9610379;Reactome: R-HSA-174490;Reactome: R-HSA-162588;Reactome: R-HSA-917729;Reactome: R-HSA-9615710 "HCMV Late Events";"Membrane binding and targetting of GAG proteins";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy" XP_046738344.1 2 Reactome: R-HSA-418555;Reactome: R-HSA-444821 "G alpha (s) signalling events";"Relaxin receptors" XP_046737682.1 1 Reactome: R-HSA-428890 "Role of ABL in ROBO-SLIT signaling" XP_046742441.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046745201.1 4 Reactome: R-HSA-3108214;Reactome: R-HSA-532668;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394 "SUMOylation of DNA damage response and repair proteins";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER" XP_046752481.1 1 Reactome: R-HSA-499943 "Interconversion of nucleotide di- and triphosphates" XP_046747414.1 3 MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2 "Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism" XP_046749397.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes" XP_046747626.1 2 Reactome: R-HSA-5357905;Reactome: R-HSA-8876198 "Regulation of TNFR1 signaling";"RAB GEFs exchange GTP for GDP on RABs" XP_046748024.1 2 Reactome: R-HSA-4641265;Reactome: R-HSA-5339700 "Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP" XP_046752345.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046752045.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046753479.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046750041.1 6 KEGG: 00510+2.4.1.143;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578;Reactome: R-HSA-4793952 "N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)" XP_046737714.1 1 Reactome: R-HSA-114608 "Platelet degranulation" XP_046740881.1 1 Reactome: R-HSA-437239 "Recycling pathway of L1" XP_046744075.1 17 MetaCyc: PWY-5744;Reactome: R-HSA-3371599;MetaCyc: PWY-5789;Reactome: R-HSA-200425;KEGG: 00640+6.4.1.2;Reactome: R-HSA-2426168;Reactome: R-HSA-163765;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6679;MetaCyc: PWY-5743;Reactome: R-HSA-196780;MetaCyc: PWY-4381;MetaCyc: PWY-5966-1;KEGG: 00720+6.4.1.2;KEGG: 00254+6.4.1.2;KEGG: 00620+6.4.1.2;MetaCyc: PWY-6722 "Glyoxylate assimilation";"Defective HLCS causes multiple carboxylase deficiency";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Carnitine metabolism";"Propanoate metabolism";"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis";"Jadomycin biosynthesis";"3-hydroxypropanoate cycle";"Biotin transport and metabolism";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Carbon fixation pathways in prokaryotes";"Aflatoxin biosynthesis";"Pyruvate metabolism";"Candicidin biosynthesis" XP_046746086.1 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" XP_046747475.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046750015.1 2 Reactome: R-HSA-201722;Reactome: R-HSA-3769402 "Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex" XP_046747529.1 3 Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" XP_046739667.1 3 Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-8963901 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Chylomicron remodeling" XP_046746255.1 1 MetaCyc: PWY-7942 "5-oxo-L-proline metabolism" XP_046749370.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046753242.1 19 Reactome: R-HSA-9022692;Reactome: R-HSA-6802955;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-111932;Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-6802952;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-5673000;Reactome: R-HSA-438066;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-9649948;Reactome: R-HSA-399719;Reactome: R-HSA-442982 "Regulation of MECP2 expression and activity";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"CaMK IV-mediated phosphorylation of CREB";"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by BRAF and RAF fusions";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"RAF activation";"Unblocking of NMDA receptors, glutamate binding and activation";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Signaling downstream of RAS mutants";"Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor" XP_046752558.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046746491.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046740789.1 2 KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1 "Purine metabolism";"Pentose phosphate pathway" XP_046749392.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046753759.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046745702.1 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" XP_046745477.1 5 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-176407;Reactome: R-HSA-5687128;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"MAPK6/MAPK4 signaling";"T cell receptor signaling pathway" XP_046743134.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046738574.1 3 Reactome: R-HSA-3899300;Reactome: R-HSA-9609690;Reactome: R-HSA-6804757 "SUMOylation of transcription cofactors";"HCMV Early Events";"Regulation of TP53 Degradation" XP_046751316.1 2 Reactome: R-HSA-426117;Reactome: R-HSA-5619039 "Cation-coupled Chloride cotransporters";"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)" XP_046740365.1 6 Reactome: R-HSA-975957;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-9010553;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046746663.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046751291.1 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" XP_046753529.1 18 MetaCyc: PWY-7226;MetaCyc: PWY-7224;MetaCyc: PWY-6545;MetaCyc: PWY-7227;MetaCyc: PWY-7221;MetaCyc: PWY-7205;MetaCyc: PWY-7198;KEGG: 00240+2.7.4.6;Reactome: R-HSA-499943;MetaCyc: PWY-7210;MetaCyc: PWY-7220;MetaCyc: PWY-7197;MetaCyc: PWY-7176;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7187;MetaCyc: PWY-7222;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7184 "Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"CMP phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"UTP and CTP de novo biosynthesis";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I" XP_046742745.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046748276.1 2 Reactome: R-HSA-8849175;KEGG: 00260+2.3.1.29 "Threonine catabolism";"Glycine, serine and threonine metabolism" XP_046747484.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046737937.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046734447.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046746117.1 9 Reactome: R-HSA-382556;Reactome: R-HSA-5689880;Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-9646399;Reactome: R-HSA-5627083;Reactome: R-HSA-8856828;Reactome: R-HSA-9613829;Reactome: R-HSA-5678895 "ABC-family proteins mediated transport";"Ub-specific processing proteases";"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Aggrephagy";"RHO GTPases regulate CFTR trafficking";"Clathrin-mediated endocytosis";"Chaperone Mediated Autophagy";"Defective CFTR causes cystic fibrosis" XP_046740855.1 1 Reactome: R-HSA-446210 "Synthesis of UDP-N-acetyl-glucosamine" XP_046750820.1 13 KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;MetaCyc: PWY-2161;KEGG: 00670+6.3.4.3;MetaCyc: PWY-5030;MetaCyc: PWY-2201;MetaCyc: PWY-6613;KEGG: 00720+6.3.4.3;MetaCyc: PWY-7909;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-1722;MetaCyc: PWY-5497;Reactome: R-HSA-196757 "Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Folate polyglutamylation";"One carbon pool by folate";"L-histidine degradation III";"Folate transformations I";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Carbon fixation pathways in prokaryotes";"Formaldehyde oxidation VII (THF pathway)";"One carbon pool by folate";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Purine nucleobases degradation II (anaerobic)";"Metabolism of folate and pterines" XP_046737513.1 5 Reactome: R-HSA-3249367;Reactome: R-HSA-6798695;Reactome: R-HSA-1834941;Reactome: R-HSA-3134975;Reactome: R-HSA-3270619 "STAT6-mediated induction of chemokines";"Neutrophil degranulation";"STING mediated induction of host immune responses";"Regulation of innate immune responses to cytosolic DNA";"IRF3-mediated induction of type I IFN" XP_046734327.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046752383.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046749387.1 1 Reactome: R-HSA-420029 "Tight junction interactions" XP_046749471.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046750752.1 3 Reactome: R-HSA-110357;Reactome: R-HSA-110331;Reactome: R-HSA-110330 "Displacement of DNA glycosylase by APEX1";"Cleavage of the damaged purine";"Recognition and association of DNA glycosylase with site containing an affected purine" XP_046739664.1 2 Reactome: R-HSA-4090294;Reactome: R-HSA-383280 "SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway" XP_046749439.1 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" XP_046752300.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046737037.1 16 Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-176407;Reactome: R-HSA-176409;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-176412;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-174048 "Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"Phosphorylation of the APC/C";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Cyclin B" XP_046747846.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046751847.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046744697.1 1 Reactome: R-HSA-4615885 "SUMOylation of DNA replication proteins" XP_046748982.1 1 Reactome: R-HSA-8964038 "LDL clearance" XP_046742511.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046745524.1 4 Reactome: R-HSA-6807047;MetaCyc: PWY-8026;Reactome: R-HSA-6807062;KEGG: 00100+1.3.1.72 "Cholesterol biosynthesis via desmosterol";"Sterol biosynthesis (methylotrophs)";"Cholesterol biosynthesis via lathosterol";"Steroid biosynthesis" XP_046746199.1 3 Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-6798695 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Neutrophil degranulation" XP_046752119.1 1 Reactome: R-HSA-72165 "mRNA Splicing - Minor Pathway" XP_046740005.1 3 Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation" XP_046737459.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046738733.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046751792.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046746293.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" XP_046745688.1 2 KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753 "Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism" XP_046741587.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046739335.1 1 Reactome: R-HSA-381038 "XBP1(S) activates chaperone genes" XP_046749391.1 2 Reactome: R-HSA-389661;Reactome: R-HSA-2408508 "Glyoxylate metabolism and glycine degradation";"Metabolism of ingested SeMet, Sec, MeSec into H2Se" XP_046751025.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046738241.1 57 Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-1236974;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-75815;Reactome: R-HSA-5358346;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-983168;Reactome: R-HSA-4641258;Reactome: R-HSA-180585;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8951664;Reactome: R-HSA-450408;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-6798695;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-5658442;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091 "Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"ER-Phagosome pathway";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog ligand biogenesis";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of DVL";"Vif-mediated degradation of APOBEC3G";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Neutrophil degranulation";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Regulation of RAS by GAPs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells" XP_046736125.1 5 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72165;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046748287.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046747148.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046737789.1 12 KEGG: 00710+4.1.2.13;KEGG: 00010+4.1.2.13;KEGG: 00680+4.1.2.13;KEGG: 00030+4.1.2.13;Reactome: R-HSA-70263;Reactome: R-HSA-70171;KEGG: 00051+4.1.2.13;MetaCyc: PWY-6142;MetaCyc: PWY-1861;MetaCyc: PWY-1042;MetaCyc: PWY-7385;MetaCyc: PWY-5484 "Carbon fixation in photosynthetic organisms";"Glycolysis / Gluconeogenesis";"Methane metabolism";"Pentose phosphate pathway";"Gluconeogenesis";"Glycolysis";"Fructose and mannose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)" XP_046741199.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046749983.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" XP_046740072.1 1 Reactome: R-HSA-1483191 "Synthesis of PC" XP_046743423.1 1 Reactome: R-HSA-425410 "Metal ion SLC transporters" XP_046749873.1 3 Reactome: R-HSA-8951664;MetaCyc: PWY-7511;Reactome: R-HSA-349425 "Neddylation";"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1" XP_046751353.1 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" XP_046753756.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046752056.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046743895.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046744191.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046738938.1 7 Reactome: R-HSA-5658034;Reactome: R-HSA-5358346;Reactome: R-HSA-5632684;Reactome: R-HSA-373080;Reactome: R-HSA-5635838;Reactome: R-HSA-5362798;Reactome: R-HSA-5632681 "HHAT G278V abrogates palmitoylation of Hh-Np";"Hedgehog ligand biogenesis";"Hedgehog 'on' state";"Class B/2 (Secretin family receptors)";"Activation of SMO";"Release of Hh-Np from the secreting cell";"Ligand-receptor interactions" XP_046745163.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046734010.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046749195.1 2 Reactome: R-HSA-5693568;Reactome: R-HSA-6783310 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway" XP_046736803.1 15 Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-5358752;Reactome: R-HSA-5467348;Reactome: R-HSA-5467340;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-111465;Reactome: R-HSA-195253;Reactome: R-HSA-3769402;Reactome: R-HSA-5467333;Reactome: R-HSA-5339716;Reactome: R-HSA-5689896 "APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"AXIN missense mutants destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Apoptotic cleavage of cellular proteins";"Degradation of beta-catenin by the destruction complex";"Deactivation of the beta-catenin transactivating complex";"APC truncation mutants are not K63 polyubiquitinated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Ovarian tumor domain proteases" XP_046743684.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046750191.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046747208.1 3 Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" XP_046738232.1 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" XP_046751491.1 4 MetaCyc: PWY-5188;Reactome: R-HSA-189451;KEGG: 00860+2.5.1.61;MetaCyc: PWY-5189 "Tetrapyrrole biosynthesis I (from glutamate)";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis II (from glycine)" XP_046744337.1 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" XP_046745839.1 6 MetaCyc: PWY-4261;Reactome: R-HSA-163560;Reactome: R-HSA-1483166;MetaCyc: PWY-6952;MetaCyc: PWY-6118;KEGG: 00564+1.1.5.3 "Glycerol degradation I";"Triglyceride catabolism";"Synthesis of PA";"Glycerophosphodiester degradation";"Glycerol-3-phosphate shuttle";"Glycerophospholipid metabolism" XP_046748543.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046751200.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046750496.1 22 Reactome: R-HSA-2500257;Reactome: R-HSA-5675221;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-5358752;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-9648025;Reactome: R-HSA-5673000;Reactome: R-HSA-5358747;Reactome: R-HSA-5467340;Reactome: R-HSA-5358751;Reactome: R-HSA-195253;Reactome: R-HSA-5467348;Reactome: R-HSA-6811558;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-432142;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "Resolution of Sister Chromatid Cohesion";"Negative regulation of MAPK pathway";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"T41 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"EML4 and NUDC in mitotic spindle formation";"RAF activation";"S33 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"Truncations of AMER1 destabilize the destruction complex";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"Platelet sensitization by LDL";"Mitotic Prometaphase";"RHO GTPases Activate Formins" XP_046742006.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046739218.1 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" XP_046740074.1 5 Reactome: R-HSA-9610379;Reactome: R-HSA-9615710;Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-174490 "HCMV Late Events";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"Membrane binding and targetting of GAG proteins" XP_046750429.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046741855.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046737516.1 5 Reactome: R-HSA-1834941;Reactome: R-HSA-3249367;Reactome: R-HSA-6798695;Reactome: R-HSA-3270619;Reactome: R-HSA-3134975 "STING mediated induction of host immune responses";"STAT6-mediated induction of chemokines";"Neutrophil degranulation";"IRF3-mediated induction of type I IFN";"Regulation of innate immune responses to cytosolic DNA" XP_046746790.1 19 Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-8856825;Reactome: R-HSA-3000497;Reactome: R-HSA-8856828;Reactome: R-HSA-381426;Reactome: R-HSA-8964026;Reactome: R-HSA-8964041;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471;Reactome: R-HSA-8957275;Reactome: R-HSA-975634;Reactome: R-HSA-8964038;Reactome: R-HSA-202733;Reactome: R-HSA-8963888;Reactome: R-HSA-3000480;Reactome: R-HSA-8963901;Reactome: R-HSA-8964046;Reactome: R-HSA-3000484 "Platelet sensitization by LDL";"VLDL assembly";"Cargo recognition for clathrin-mediated endocytosis";"Scavenging by Class H Receptors";"Clathrin-mediated endocytosis";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Chylomicron clearance";"LDL remodeling";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors";"Post-translational protein phosphorylation";"Retinoid metabolism and transport";"LDL clearance";"Cell surface interactions at the vascular wall";"Chylomicron assembly";"Scavenging by Class A Receptors";"Chylomicron remodeling";"VLDL clearance";"Scavenging by Class F Receptors" XP_046742369.1 8 KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-428540 "mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"Activation of RAC1" XP_046747627.1 2 Reactome: R-HSA-5357905;Reactome: R-HSA-8876198 "Regulation of TNFR1 signaling";"RAB GEFs exchange GTP for GDP on RABs" XP_046741557.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046751962.1 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" XP_046744564.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046752814.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway" XP_046746228.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046735217.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046735608.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046737015.1 5 KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00380+1.2.4.2;Reactome: R-HSA-389661;MetaCyc: PWY-5084 "Lysine degradation";"Citrate cycle (TCA cycle)";"Tryptophan metabolism";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA" XP_046749569.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046751925.1 3 KEGG: 00790+4.1.99.22;MetaCyc: PWY-6823;Reactome: R-HSA-947581 "Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis" XP_046743611.1 7 MetaCyc: PWY-7782;KEGG: 00564+2.7.1.32+2.7.1.82;MetaCyc: PWY-7886;MetaCyc: PWY-7818;MetaCyc: PWY-3385;Reactome: R-HSA-1483213;Reactome: R-HSA-1483191 "Plasmalogen biosynthesis";"Glycerophospholipid metabolism";"Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)";"Choline biosynthesis I";"Synthesis of PE";"Synthesis of PC" XP_046742337.1 3 Reactome: R-HSA-6804115;Reactome: R-HSA-5617472;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deadenylation of mRNA" XP_046741606.1 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" XP_046750042.1 6 Reactome: R-HSA-975578;MetaCyc: PWY-7920;Reactome: R-HSA-4793952;KEGG: 00510+2.4.1.143;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7426 "Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (plants)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)" XP_046737857.1 44 Reactome: R-HSA-9634638;Reactome: R-HSA-9649948;Reactome: R-HSA-450341;Reactome: R-HSA-5663213;Reactome: R-HSA-881907;Reactome: R-HSA-9635465;Reactome: R-HSA-202670;Reactome: R-HSA-8943724;Reactome: R-HSA-3371453;Reactome: R-HSA-112409;Reactome: R-HSA-198753;Reactome: R-HSA-6802948;Reactome: R-HSA-8939211;Reactome: R-HSA-170968;Reactome: R-HSA-5674135;Reactome: R-HSA-6811558;Reactome: R-HSA-456926;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-2029482;Reactome: R-HSA-879415;Reactome: R-HSA-5654733;Reactome: R-HSA-5674499;Reactome: R-HSA-6802952;Reactome: R-HSA-8940973;Reactome: R-HSA-2559585;Reactome: R-HSA-5654726;Reactome: R-HSA-2871796;Reactome: R-HSA-1295596;Reactome: R-HSA-5675221;Reactome: R-HSA-445144;Reactome: R-HSA-74749;Reactome: R-HSA-5654727;Reactome: R-HSA-9627069;Reactome: R-HSA-982772;KEGG: 04150+2.7.11.24;Reactome: R-HSA-5668599;Reactome: R-HSA-2559582;Reactome: R-HSA-2559580;Reactome: R-HSA-162658;Reactome: R-HSA-444257;Reactome: R-HSA-375165;Reactome: R-HSA-5654732;Reactome: R-HSA-6802946 "Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Signaling downstream of RAS mutants";"Activation of the AP-1 family of transcription factors";"RHO GTPases Activate WASPs and WAVEs";"Gastrin-CREB signalling pathway via PKC and MAPK";"Suppression of apoptosis";"ERKs are inactivated";"Regulation of PTEN gene transcription";"Regulation of HSF1-mediated heat shock response";"RAF-independent MAPK1/3 activation";"ERK/MAPK targets";"Signaling by high-kinase activity BRAF mutants";"ESR-mediated signaling";"Frs2-mediated activation";"MAP2K and MAPK activation";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Thrombin signalling through proteinase activated receptors (PARs)";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of actin dynamics for phagocytic cup formation";"Advanced glycosylation endproduct receptor signaling";"Negative regulation of FGFR4 signaling";"Negative feedback regulation of MAPK pathway";"Signaling by BRAF and RAF fusions";"RUNX2 regulates osteoblast differentiation";"Oncogene Induced Senescence";"Negative regulation of FGFR1 signaling";"FCERI mediated MAPK activation";"Spry regulation of FGF signaling";"Negative regulation of MAPK pathway";"Signal transduction by L1";"Signal attenuation";"Negative regulation of FGFR2 signaling";"Regulation of the apoptosome activity";"Growth hormone receptor signaling";"mTOR signaling pathway";"RHO GTPases Activate NADPH Oxidases";"Senescence-Associated Secretory Phenotype (SASP)";"Oxidative Stress Induced Senescence";"Golgi Cisternae Pericentriolar Stack Reorganization";"RSK activation";"NCAM signaling for neurite out-growth";"Negative regulation of FGFR3 signaling";"Signaling by moderate kinase activity BRAF mutants" XP_046743928.1 1 Reactome: R-HSA-5628897 "TP53 Regulates Metabolic Genes" XP_046753528.1 16 Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823 "SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation" XP_046740056.1 14 Reactome: R-HSA-3769402;Reactome: R-HSA-2500257;Reactome: R-HSA-2173788;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-450520;Reactome: R-HSA-69273;Reactome: R-HSA-141444;Reactome: R-HSA-5687128;Reactome: R-HSA-9634638;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025 "Deactivation of the beta-catenin transactivating complex";"Resolution of Sister Chromatid Cohesion";"Downregulation of TGF-beta receptor signaling";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"HuR (ELAVL1) binds and stabilizes mRNA";"Cyclin A/B1/B2 associated events during G2/M transition";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"MAPK6/MAPK4 signaling";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation" XP_046748952.1 5 KEGG: 00630+4.2.1.3;KEGG: 00720+4.2.1.3;KEGG: 00020+4.2.1.3;KEGG: 00290+4.2.1.33;Reactome: R-HSA-917937 "Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine biosynthesis";"Iron uptake and transport" XP_046738420.1 4 Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-5676590 "Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"NIK-->noncanonical NF-kB signaling" XP_046743270.1 6 MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463 "Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis" XP_046749706.1 1 Reactome: R-HSA-373753 "Nephrin family interactions" XP_046736592.1 3 Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination" XP_046752374.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046753229.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046746797.1 13 Reactome: R-HSA-112043;Reactome: R-HSA-4086398;Reactome: R-HSA-2871809;Reactome: R-HSA-381676;Reactome: R-HSA-139853;Reactome: R-HSA-422356;Reactome: R-HSA-5578775;Reactome: R-HSA-5607763;Reactome: R-HSA-5218921;Reactome: R-HSA-2029485;Reactome: R-HSA-114508;Reactome: R-HSA-1489509;Reactome: R-HSA-983695 "PLC beta mediated events";"Ca2+ pathway";"FCERI mediated Ca+2 mobilization";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Elevation of cytosolic Ca2+ levels";"Regulation of insulin secretion";"Ion homeostasis";"CLEC7A (Dectin-1) induces NFAT activation";"VEGFR2 mediated cell proliferation";"Role of phospholipids in phagocytosis";"Effects of PIP2 hydrolysis";"DAG and IP3 signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" XP_046744365.1 12 Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025 "HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation" XP_046748184.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046739665.1 2 Reactome: R-HSA-4090294;Reactome: R-HSA-383280 "SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway" XP_046742780.1 33 Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-141444;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-159231;Reactome: R-HSA-2500257;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-5578749;Reactome: R-HSA-5663220;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-159230;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-159227;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-191859;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-5619107;Reactome: R-HSA-1169408 "SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Resolution of Sister Chromatid Cohesion";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"Transcriptional regulation by small RNAs";"RHO GTPases Activate Formins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP independent Mature mRNA";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"snRNP Assembly";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Nuclear import of Rev protein";"Mitotic Prometaphase";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"ISG15 antiviral mechanism" XP_046734854.1 2 KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383 "Other glycan degradation";"Lysosomal oligosaccharide catabolism" XP_046740824.1 3 MetaCyc: PWY-7856;KEGG: 00860+2.5.1.141;Reactome: R-HSA-189451 "Heme a biosynthesis";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis" XP_046753231.1 19 Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-438066;Reactome: R-HSA-9649948;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-5673000;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-6802946;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-6802955;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-9022692 "Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"Signaling downstream of RAS mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"RAF activation";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"Signaling by moderate kinase activity BRAF mutants";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Regulation of MECP2 expression and activity" XP_046741276.1 19 MetaCyc: PWY-5537;Reactome: R-HSA-75105;MetaCyc: PWY-5172;MetaCyc: PWY-6969;MetaCyc: PWY-5690;MetaCyc: PWY-5538;KEGG: 00720+2.3.3.8;KEGG: 00640+6.2.1.5;Reactome: R-HSA-6798695;MetaCyc: PWY-7384;KEGG: 00660+6.2.1.5;MetaCyc: PWY-6728;Reactome: R-HSA-163765;KEGG: 00020+2.3.3.8;Reactome: R-HSA-71403;MetaCyc: PWY-5392;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5913;KEGG: 00720+6.2.1.5 "Pyruvate fermentation to acetate V";"Fatty acyl-CoA biosynthesis";"Acetyl-coa biosynthesis III (from citrate)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle II (plants and fungi)";"Pyruvate fermentation to acetate VI";"Carbon fixation pathways in prokaryotes";"Propanoate metabolism";"Neutrophil degranulation";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"C5-Branched dibasic acid metabolism";"Methylaspartate cycle";"ChREBP activates metabolic gene expression";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Reductive TCA cycle II";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Carbon fixation pathways in prokaryotes" XP_046747090.1 3 Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" XP_046736116.1 5 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159231;Reactome: R-HSA-77595;Reactome: R-HSA-72163 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA Derived from an Intronless Transcript";"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway" XP_046742883.1 3 KEGG: 00561+3.1.1.3;MetaCyc: PWY-6857;Reactome: R-HSA-192456 "Glycerolipid metabolism";"Retinol biosynthesis";"Digestion of dietary lipid" XP_046746187.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046746749.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046753907.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046744434.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046745005.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046735791.1 2 Reactome: R-HSA-70895;KEGG: 00280+1.1.1.31 "Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation" XP_046734686.1 3 Reactome: R-HSA-983189;Reactome: R-HSA-390471;Reactome: R-HSA-6811434 "Kinesins";"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046741017.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046742437.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046749438.1 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" XP_046747358.1 3 Reactome: R-HSA-5696394;Reactome: R-HSA-3214847;Reactome: R-HSA-5689603 "DNA Damage Recognition in GG-NER";"HATs acetylate histones";"UCH proteinases" XP_046735501.1 15 Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-167238;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-113418 "Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex" XP_046742539.1 3 Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916 "Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium" XP_046744768.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046742396.1 7 MetaCyc: PWY-7039;Reactome: R-HSA-1483148;Reactome: R-HSA-1483166;Reactome: R-HSA-2029485;KEGG: 00565+3.1.4.4;MetaCyc: PWY-3561;KEGG: 00564+3.1.4.4 "Phosphatidate metabolism, as a signaling molecule";"Synthesis of PG";"Synthesis of PA";"Role of phospholipids in phagocytosis";"Ether lipid metabolism";"Choline biosynthesis III";"Glycerophospholipid metabolism" XP_046744985.1 1 KEGG: 00450+1.8.1.9 "Selenocompound metabolism" XP_046747146.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046740814.1 33 Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-68877;Reactome: R-HSA-1169408;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-159227;Reactome: R-HSA-191859;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-5663220;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-159230;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-168271;Reactome: R-HSA-2500257;Reactome: R-HSA-159231;Reactome: R-HSA-165054 "Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Mitotic Prometaphase";"ISG15 antiviral mechanism";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP independent Mature mRNA";"snRNP Assembly";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"RHO GTPases Activate Formins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Ribonucleoproteins into the Host Nucleus";"Resolution of Sister Chromatid Cohesion";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA" XP_046752337.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046735979.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046741367.1 4 KEGG: 00500+3.1.3.9;Reactome: R-HSA-70263;KEGG: 00052+3.1.3.9;KEGG: 00010+3.1.3.9 "Starch and sucrose metabolism";"Gluconeogenesis";"Galactose metabolism";"Glycolysis / Gluconeogenesis" XP_046743499.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046750256.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046751074.1 56 Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-450408;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-5658442;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-1236974;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-75815;Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-983168;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-180585 "Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Regulation of RAS by GAPs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"ER-Phagosome pathway";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G" XP_046745173.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046735786.1 24 Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-6807878 "Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Cilium Assembly";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"COPI-mediated anterograde transport" XP_046742014.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046744327.1 12 Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257 "RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion" XP_046745313.1 14 Reactome: R-HSA-8948700;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-203927;Reactome: R-HSA-9022692;Reactome: R-HSA-4086398;Reactome: R-HSA-426486;Reactome: R-HSA-9029569;Reactome: R-HSA-8934593;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408 "Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"MicroRNA (miRNA) biogenesis";"Regulation of MECP2 expression and activity";"Ca2+ pathway";"Small interfering RNA (siRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of RUNX1 Expression and Activity";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation" XP_046745203.1 2 Reactome: R-HSA-2299718;Reactome: R-HSA-2514853 "Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes" XP_046753630.1 1 Reactome: R-HSA-186797 "Signaling by PDGF" XP_046738787.1 13 Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9633012 "L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046734546.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046737768.1 5 MetaCyc: PWY-6692;MetaCyc: PWY-7279;KEGG: 00190+7.1.1.8;MetaCyc: PWY-7082;MetaCyc: PWY-3781 "Fe(II) oxidation";"Aerobic respiration II (cytochrome c) (yeast)";"Oxidative phosphorylation";"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Aerobic respiration I (cytochrome c)" XP_046740941.1 7 Reactome: R-HSA-379716;MetaCyc: PWY-5188;Reactome: R-HSA-2408522;KEGG: 00860+6.1.1.17;Reactome: R-HSA-6782315;KEGG: 00970+6.1.1.17;KEGG: 00970+6.1.1.15 "Cytosolic tRNA aminoacylation";"Tetrapyrrole biosynthesis I (from glutamate)";"Selenoamino acid metabolism";"Porphyrin and chlorophyll metabolism";"tRNA modification in the nucleus and cytosol";"Aminoacyl-tRNA biosynthesis";"Aminoacyl-tRNA biosynthesis" XP_046745799.1 1 Reactome: R-HSA-499943 "Interconversion of nucleotide di- and triphosphates" XP_046740785.1 2 KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1 "Pentose phosphate pathway";"Purine metabolism" XP_046738856.1 10 Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-9648895;Reactome: R-HSA-156827;Reactome: R-HSA-381042;Reactome: R-HSA-72731;Reactome: R-HSA-9633012;Reactome: R-HSA-382556;Reactome: R-HSA-72702;Reactome: R-HSA-72706 "Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"Response of EIF2AK1 (HRI) to heme deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"PERK regulates gene expression";"Recycling of eIF2:GDP";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"ABC-family proteins mediated transport";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046747585.1 3 MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1 "Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism" XP_046741474.1 3 MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2 "Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism" XP_046737693.1 19 MetaCyc: PWY-7205;MetaCyc: PWY-7198;MetaCyc: PWY-7221;MetaCyc: PWY-7227;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7210;Reactome: R-HSA-380270;MetaCyc: PWY-7226;MetaCyc: PWY-6545;MetaCyc: PWY-7224;MetaCyc: PWY-7176;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7222;MetaCyc: PWY-7187;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7184;MetaCyc: PWY-7220;MetaCyc: PWY-7197;Reactome: R-HSA-380320 "CMP phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine ribonucleotides de novo biosynthesis";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Recruitment of mitotic centrosome proteins and complexes";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine deoxyribonucleosides salvage";"UTP and CTP de novo biosynthesis";"Drug metabolism - other enzymes";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Recruitment of NuMA to mitotic centrosomes" XP_046740369.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046749521.1 2 KEGG: 00860+4.99.1.1;Reactome: R-HSA-189451 "Porphyrin and chlorophyll metabolism";"Heme biosynthesis" XP_046745898.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046739728.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046745791.1 2 Reactome: R-HSA-3371599;Reactome: R-HSA-196780 "Defective HLCS causes multiple carboxylase deficiency";"Biotin transport and metabolism" XP_046751690.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046739770.1 1 Reactome: R-HSA-8963901 "Chylomicron remodeling" XP_046739706.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046740823.1 3 KEGG: 00860+2.5.1.141;Reactome: R-HSA-189451;MetaCyc: PWY-7856 "Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Heme a biosynthesis" XP_046736202.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046739334.1 1 KEGG: 00970+6.1.1.20 "Aminoacyl-tRNA biosynthesis" XP_046736199.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046745893.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046742467.1 13 MetaCyc: PWY-6728;MetaCyc: PWY-5537;Reactome: R-HSA-71403;MetaCyc: PWY-6969;MetaCyc: PWY-5392;MetaCyc: PWY-5690;MetaCyc: PWY-7384;KEGG: 00660+6.2.1.5;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5913;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538 "Methylaspartate cycle";"Pyruvate fermentation to acetate V";"Citric acid cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"C5-Branched dibasic acid metabolism";"Carbon fixation pathways in prokaryotes";"Partial TCA cycle (obligate autotrophs)";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI" XP_046734511.1 2 Reactome: R-HSA-430039;Reactome: R-HSA-72163 "mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway" XP_046735536.1 3 Reactome: R-HSA-73843;KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1 "5-Phosphoribose 1-diphosphate biosynthesis";"Pentose phosphate pathway";"Purine metabolism" XP_046751265.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046750796.1 11 Reactome: R-HSA-5696397;Reactome: R-HSA-174430;Reactome: R-HSA-5651801;Reactome: R-HSA-68962;Reactome: R-HSA-6782210;Reactome: R-HSA-5685942;Reactome: R-HSA-68952;Reactome: R-HSA-110314;Reactome: R-HSA-5656169;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400 "Gap-filling DNA repair synthesis and ligation in GG-NER";"Telomere C-strand synthesis initiation";"PCNA-Dependent Long Patch Base Excision Repair";"Activation of the pre-replicative complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HDR through Homologous Recombination (HRR)";"DNA replication initiation";"Recognition of DNA damage by PCNA-containing replication complex";"Termination of translesion DNA synthesis";"Dual incision in TC-NER";"Dual Incision in GG-NER" XP_046742806.1 2 Reactome: R-HSA-975577;Reactome: R-HSA-2022854 "N-Glycan antennae elongation";"Keratan sulfate biosynthesis" XP_046745757.1 17 Reactome: R-HSA-5696397;Reactome: R-HSA-6782210;Reactome: R-HSA-5358606;Reactome: R-HSA-174437;Reactome: R-HSA-174414;Reactome: R-HSA-69183;Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-174417;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-110314;Reactome: R-HSA-69166;Reactome: R-HSA-5685942;Reactome: R-HSA-6782135;Reactome: R-HSA-5358565;Reactome: R-HSA-5656169 "Gap-filling DNA repair synthesis and ligation in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Removal of the Flap Intermediate from the C-strand";"Processive synthesis on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Dual Incision in GG-NER";"Polymerase switching";"Telomere C-strand (Lagging Strand) Synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate";"HDR through Homologous Recombination (HRR)";"Dual incision in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Termination of translesion DNA synthesis" XP_046747510.1 3 Reactome: R-HSA-749476;Reactome: R-HSA-6807505;Reactome: R-HSA-76071 "RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" XP_046749290.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046747383.1 6 Reactome: R-HSA-74259;MetaCyc: PWY-6608;MetaCyc: PWY-5497;MetaCyc: PWY-6606;MetaCyc: PWY-7442;KEGG: 00230+3.5.4.3 "Purine catabolism";"Guanosine nucleotides degradation III";"Purine nucleobases degradation II (anaerobic)";"Guanosine nucleotides degradation II";"Drosopterin and aurodrosopterin biosynthesis";"Purine metabolism" XP_046736860.1 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" XP_046740400.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046735747.1 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" XP_046753421.1 5 MetaCyc: PWY-7269;MetaCyc: PWY-5083;Reactome: R-HSA-196807;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268 "NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)" XP_046744674.1 13 Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823 "Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation" XP_046734094.1 3 KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046742982.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046752255.1 3 KEGG: 00561+3.1.1.23;Reactome: R-HSA-426048;MetaCyc: PWY-7420 "Glycerolipid metabolism";"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)" XP_046753306.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046734324.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046751958.1 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" XP_046749388.1 2 Reactome: R-HSA-2408508;Reactome: R-HSA-389661 "Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Glyoxylate metabolism and glycine degradation" XP_046746189.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046750173.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046745972.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046747356.1 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" XP_046738126.1 2 Reactome: R-HSA-416993;Reactome: R-HSA-202733 "Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall" XP_046739467.1 5 MetaCyc: PWY-7918;KEGG: 00510+3.2.1.106;Reactome: R-HSA-4793954;MetaCyc: PWY-7919;Reactome: R-HSA-532668 "Protein N-glycosylation processing phase (yeast)";"N-Glycan biosynthesis";"Defective MOGS causes MOGS-CDG (CDG-2b)";"Protein N-glycosylation processing phase (plants and animals)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle" XP_046741234.1 4 Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712 "Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport" XP_046745325.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" XP_046746439.1 7 Reactome: R-HSA-5083633;Reactome: R-HSA-3000171;Reactome: R-HSA-5083629;Reactome: R-HSA-5083628;Reactome: R-HSA-5173105;Reactome: R-HSA-9010553;Reactome: R-HSA-3000178 "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Non-integrin membrane-ECM interactions";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"O-linked glycosylation";"Regulation of expression of SLITs and ROBOs";"ECM proteoglycans" XP_046752218.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046739273.1 1 Reactome: R-HSA-70895 "Branched-chain amino acid catabolism" XP_046735056.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046738982.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046742630.1 9 MetaCyc: PWY-7115;MetaCyc: PWY-5789;MetaCyc: PWY-241;MetaCyc: PWY-6142;MetaCyc: PWY-5744;MetaCyc: PWY-5743;KEGG: 00910+4.2.1.1;Reactome: R-HSA-1475029;MetaCyc: PWY-7117 "C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glyoxylate assimilation";"3-hydroxypropanoate cycle";"Nitrogen metabolism";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type" XP_046753880.1 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" XP_046748810.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046736502.1 2 Reactome: R-HSA-5663220;Reactome: R-HSA-376176 "RHO GTPases Activate Formins";"Signaling by ROBO receptors" XP_046735837.1 2 Reactome: R-HSA-114608;KEGG: 00970+6.1.1.3 "Platelet degranulation";"Aminoacyl-tRNA biosynthesis" XP_046743730.1 33 Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-159227;Reactome: R-HSA-191859;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-68877;Reactome: R-HSA-168271;Reactome: R-HSA-2500257;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-159230;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-5578749;Reactome: R-HSA-5663220 "HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP independent Mature mRNA";"snRNP Assembly";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Mitotic Prometaphase";"Transport of Ribonucleoproteins into the Host Nucleus";"Resolution of Sister Chromatid Cohesion";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA replication proteins";"HCMV Late Events";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Transcriptional regulation by small RNAs";"RHO GTPases Activate Formins" XP_046744217.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046746288.1 1 Reactome: R-HSA-611105 "Respiratory electron transport" XP_046745353.1 2 Reactome: R-HSA-5576894;Reactome: R-HSA-1296072 "Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels" XP_046752393.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046734510.1 2 Reactome: R-HSA-430039;Reactome: R-HSA-72163 "mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway" XP_046753879.1 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" XP_046749371.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046752425.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046746103.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046749708.1 1 Reactome: R-HSA-373753 "Nephrin family interactions" XP_046752443.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046735583.1 4 Reactome: R-HSA-2129379;Reactome: R-HSA-3000170;Reactome: R-HSA-3000178;Reactome: R-HSA-216083 "Molecules associated with elastic fibres";"Syndecan interactions";"ECM proteoglycans";"Integrin cell surface interactions" XP_046750247.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046740416.1 5 Reactome: R-HSA-69473;Reactome: R-HSA-5689901;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-5693607 "G2/M DNA damage checkpoint";"Metalloprotease DUBs";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Processing of DNA double-strand break ends" XP_046737298.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046735560.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046751751.1 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" XP_046743656.1 10 Reactome: R-HSA-2151209;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-9613354;Reactome: R-HSA-163680;Reactome: R-HSA-6804756;Reactome: R-HSA-9619483;Reactome: R-HSA-200425;Reactome: R-HSA-1445148 "Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Lipophagy";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation";"Activation of AMPK downstream of NMDARs";"Carnitine metabolism";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046751011.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046733933.1 17 Reactome: R-HSA-156902;Reactome: R-HSA-6790901;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553 "Peptide chain elongation";"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" XP_046750453.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046748639.1 1 Reactome: R-HSA-6790901 "rRNA modification in the nucleus and cytosol" XP_046747956.1 1 Reactome: R-HSA-446203 "Asparagine N-linked glycosylation" XP_046747357.1 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" XP_046750672.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046749938.1 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" XP_046748593.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046746313.1 3 Reactome: R-HSA-6784531;MetaCyc: PWY-7803;MetaCyc: PWY-6689 "tRNA processing in the nucleus";"Trna splicing II";"Trna splicing I" XP_046737476.1 7 Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942 "AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition" XP_046747882.1 6 Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450604 "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA" XP_046752122.1 1 Reactome: R-HSA-427413 "NoRC negatively regulates rRNA expression" XP_046749654.1 8 KEGG: 00524+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00052+2.7.1.1;KEGG: 00010+2.7.1.1 "Neomycin, kanamycin and gentamicin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Starch and sucrose metabolism";"Fructose and mannose metabolism";"Streptomycin biosynthesis";"Glycolysis";"Galactose metabolism";"Glycolysis / Gluconeogenesis" XP_046743517.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046749651.1 8 KEGG: 00052+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00500+2.7.1.1;KEGG: 00051+2.7.1.1 "Galactose metabolism";"Glycolysis / Gluconeogenesis";"Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Streptomycin biosynthesis";"Glycolysis";"Starch and sucrose metabolism";"Fructose and mannose metabolism" XP_046735709.1 5 Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-159231;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" XP_046746713.1 1 Reactome: R-HSA-525793 "Myogenesis" XP_046748597.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046734642.1 1 Reactome: R-HSA-5625900 "RHO GTPases activate CIT" XP_046748029.1 7 Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270 "Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes" XP_046741638.1 22 MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6958;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-7726;MetaCyc: PWY-7725;MetaCyc: PWY-5353;MetaCyc: PWY-7592;MetaCyc: PWY-6598;MetaCyc: PWY-7049;MetaCyc: PWY-7602;MetaCyc: PWY-7053;MetaCyc: PWY-7606;MetaCyc: PWY-7724;MetaCyc: PWY-7727;MetaCyc: PWY-7619;MetaCyc: PWY-7728;Reactome: R-HSA-75876;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7035 "Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Juniperonate biosynthesis";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"(9Z)-tricosene biosynthesis" XP_046753762.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046747047.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046737100.1 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" XP_046742215.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046746462.1 5 KEGG: 00190+7.1.1.8;MetaCyc: PWY-7279;MetaCyc: PWY-6692;MetaCyc: PWY-3781;MetaCyc: PWY-7082 "Oxidative phosphorylation";"Aerobic respiration II (cytochrome c) (yeast)";"Fe(II) oxidation";"Aerobic respiration I (cytochrome c)";"Ammonia oxidation IV (autotrophic ammonia oxidizers)" XP_046748987.1 26 Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-389977;Reactome: R-HSA-9648025;Reactome: R-HSA-389960;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-983189;Reactome: R-HSA-6807878;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"Post-chaperonin tubulin folding pathway";"EML4 and NUDC in mitotic spindle formation";"Formation of tubulin folding intermediates by CCT/TriC";"Cilium Assembly";"Separation of Sister Chromatids";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Kinesins";"COPI-mediated anterograde transport";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy" XP_046746377.1 7 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046740023.1 7 Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-429947;Reactome: R-HSA-166208;Reactome: R-HSA-72662 "Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Deadenylation of mRNA";"mTORC1-mediated signalling";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" XP_046751190.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase" XP_046745346.1 10 KEGG: 04660+2.7.10.2;Reactome: R-HSA-5357956;Reactome: R-HSA-5357905;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1 "T cell receptor signaling pathway";"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway" XP_046737841.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046740079.1 2 KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7 "Pyruvate metabolism";"Aminobenzoate degradation" XP_046736174.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046735351.1 2 KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20 "Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis" XP_046749843.1 2 Reactome: R-HSA-5693568;Reactome: R-HSA-6783310 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway" XP_046749332.1 1 Reactome: R-HSA-8874211 "CREB3 factors activate genes" XP_046734620.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046750255.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046736858.1 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" XP_046754054.1 5 Reactome: R-HSA-350054;Reactome: R-HSA-1912399;Reactome: R-HSA-1912408;Reactome: R-HSA-5083630;Reactome: R-HSA-1912420 "Notch-HLH transcription pathway";"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Pre-NOTCH Transcription and Translation";"Defective LFNG causes SCDO3";"Pre-NOTCH Processing in Golgi" XP_046744431.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046742909.1 2 Reactome: R-HSA-2142700;Reactome: R-HSA-2142691 "Synthesis of Lipoxins (LX)";"Synthesis of Leukotrienes (LT) and Eoxins (EX)" XP_046737378.1 5 MetaCyc: PWY-5981;MetaCyc: PWY-7817;KEGG: 00564+2.7.7.41;KEGG: 04070+2.7.7.41;MetaCyc: PWY-5667 "CDP-diacylglycerol biosynthesis III";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"CDP-diacylglycerol biosynthesis I" XP_046743012.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" XP_046753245.1 1 Reactome: R-HSA-72203 "Processing of Capped Intron-Containing Pre-mRNA" XP_046735179.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046751142.1 4 KEGG: 00564+3.1.1.32;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32 "Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism" XP_046741069.1 1 Reactome: R-HSA-162658 "Golgi Cisternae Pericentriolar Stack Reorganization" XP_046752190.1 6 Reactome: R-HSA-111367;Reactome: R-HSA-72163;Reactome: R-HSA-77588;Reactome: R-HSA-73856;Reactome: R-HSA-191859;Reactome: R-HSA-72165 "SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Major Pathway";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination";"snRNP Assembly";"mRNA Splicing - Minor Pathway" XP_046744238.1 7 Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69231;Reactome: R-HSA-6804114;Reactome: R-HSA-1362300;Reactome: R-HSA-2173796 "G0 and Early G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin D associated events in G1";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription" XP_046734212.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046746073.1 1 Reactome: R-HSA-1483101 "Synthesis of PS" XP_046743843.1 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" XP_046741818.1 3 MetaCyc: PWY-7511;Reactome: R-HSA-110314;Reactome: R-HSA-8866654 "Protein ubiquitination";"Recognition of DNA damage by PCNA-containing replication complex";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046743071.1 4 Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"MHC class II antigen presentation";"RHO GTPases activate KTN1" XP_046739021.1 14 MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-5667;MetaCyc: PWY-7587;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7589;MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7417;MetaCyc: PWY-5981;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7411;MetaCyc: PWY-7782;Reactome: R-HSA-1483166 "Anandamide biosynthesis I";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism";"Palmitoleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"Plasmalogen biosynthesis";"Synthesis of PA" XP_046741025.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046739357.1 1 Reactome: R-HSA-8964572 "Lipid particle organization" XP_046743018.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-6783310 "Protein ubiquitination";"Fanconi Anemia Pathway" XP_046751008.1 2 Reactome: R-HSA-8964038;Reactome: R-HSA-6798695 "LDL clearance";"Neutrophil degranulation" XP_046734754.1 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" XP_046743979.1 4 KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046748516.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046738956.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046753934.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046734359.1 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" XP_046742015.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046736171.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046743849.1 2 Reactome: R-HSA-168276;Reactome: R-HSA-1169408 "NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism" XP_046733778.1 1 Reactome: R-HSA-6783984 "Glycine degradation" XP_046752568.1 2 MetaCyc: PWY-7802;MetaCyc: PWY-7799 "N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)" XP_046750184.1 5 MetaCyc: PWY-5531;MetaCyc: PWY-7159;KEGG: 00860+4.1.1.37;MetaCyc: PWY-7766;Reactome: R-HSA-189451 "3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism";"Heme b biosynthesis IV (Gram-positive bacteria)";"Heme biosynthesis" XP_046734505.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046753430.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046739178.1 8 MetaCyc: PWY-5740;MetaCyc: PWY-66;MetaCyc: PWY-7573;MetaCyc: PWY-5738;MetaCyc: PWY-5739;Reactome: R-HSA-6787639;KEGG: 00051+4.2.1.47;KEGG: 00520+4.2.1.47 "GDP-L-colitose biosynthesis";"GDP-L-fucose biosynthesis I (from GDP-D-mannose)";"GDP-mycosamine biosynthesis";"GDP-6-deoxy-D-talose biosynthesis";"GDP-D-perosamine biosynthesis";"GDP-fucose biosynthesis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism" XP_046747608.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046744282.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046740797.1 52 Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-69601;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-5607761;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-1236974;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684 "Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Orc1 removal from chromatin";"Degradation of DVL";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"ER-Phagosome pathway";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state" XP_046751261.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046738282.1 8 Reactome: R-HSA-6804756;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-2151209;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-9613354 "Regulation of TP53 Activity through Phosphorylation";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Lipophagy" XP_046752570.1 2 MetaCyc: PWY-7802;MetaCyc: PWY-7799 "N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)" XP_046743528.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" XP_046750019.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046747056.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046753898.1 2 MetaCyc: PWY-5344;KEGG: 00270+2.3.1.31 "L-homocysteine biosynthesis";"Cysteine and methionine metabolism" XP_046740586.1 7 Reactome: R-HSA-70268;Reactome: R-HSA-389661;KEGG: 00010+1.2.4.1;KEGG: 00020+1.2.4.1;Reactome: R-HSA-204174;KEGG: 00620+1.2.4.1;Reactome: R-HSA-5362517 "Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Signaling by Retinoic Acid" XP_046746646.1 7 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" XP_046751530.1 1 MetaCyc: PWY-7799 "Arg/N-end rule pathway (eukaryotic)" XP_046743706.1 5 MetaCyc: PWY-3841;KEGG: 00720+1.5.1.20;KEGG: 00670+1.5.1.20;MetaCyc: PWY-2201;Reactome: R-HSA-196757 "Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"One carbon pool by folate";"Folate transformations I";"Metabolism of folate and pterines" XP_046734500.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046753553.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046753423.1 5 MetaCyc: PWY-5083;MetaCyc: PWY-7269;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807 "NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism" XP_046735154.1 19 Reactome: R-HSA-381426;Reactome: R-HSA-8856828;Reactome: R-HSA-3000497;Reactome: R-HSA-8856825;Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-3000484;Reactome: R-HSA-8964046;Reactome: R-HSA-8963901;Reactome: R-HSA-3000480;Reactome: R-HSA-8963888;Reactome: R-HSA-202733;Reactome: R-HSA-975634;Reactome: R-HSA-8964038;Reactome: R-HSA-8957275;Reactome: R-HSA-8964026;Reactome: R-HSA-8964041;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471 "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Clathrin-mediated endocytosis";"Scavenging by Class H Receptors";"Cargo recognition for clathrin-mediated endocytosis";"Platelet sensitization by LDL";"VLDL assembly";"Scavenging by Class F Receptors";"VLDL clearance";"Chylomicron remodeling";"Scavenging by Class A Receptors";"Chylomicron assembly";"Cell surface interactions at the vascular wall";"Retinoid metabolism and transport";"LDL clearance";"Post-translational protein phosphorylation";"Chylomicron clearance";"LDL remodeling";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors" XP_046747397.1 4 Reactome: R-HSA-912631;Reactome: R-HSA-8875656;Reactome: R-HSA-8875555;Reactome: R-HSA-186763 "Regulation of signaling by CBL";"MET receptor recycling";"MET activates RAP1 and RAC1";"Downstream signal transduction" XP_046738494.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097 "RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway" XP_046737431.1 4 KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193 "Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I" XP_046745244.1 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" XP_046741954.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046736020.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046745984.1 1 Reactome: R-HSA-426486 "Small interfering RNA (siRNA) biogenesis" XP_046741254.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046751206.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046748241.1 10 Reactome: R-HSA-5693616;Reactome: R-HSA-5685942;Reactome: R-HSA-69473;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-3108214;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938 "Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)";"G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"SUMOylation of DNA damage response and repair proteins";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)" XP_046734971.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046739590.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" XP_046740771.1 6 Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5685938;Reactome: R-HSA-176187;Reactome: R-HSA-69473 "Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Single Strand Annealing (SSA)";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint" XP_046748760.1 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" XP_046744287.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046752480.1 12 Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-8854518;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-381038;Reactome: R-HSA-3371497 "Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"AURKA Activation by TPX2";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"XBP1(S) activates chaperone genes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)" XP_046743513.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046737680.1 1 Reactome: R-HSA-428890 "Role of ABL in ROBO-SLIT signaling" XP_046743314.1 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.5 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046747709.1 3 Reactome: R-HSA-6807004;Reactome: R-HSA-202427;Reactome: R-HSA-6798695 "Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation" XP_046734437.1 3 Reactome: R-HSA-6784531;MetaCyc: PWY-6689;MetaCyc: PWY-7803 "tRNA processing in the nucleus";"Trna splicing I";"Trna splicing II" XP_046741937.1 3 Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340 "PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation" XP_046745599.1 4 Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394 "Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER" XP_046746310.1 1 Reactome: R-HSA-71288 "Creatine metabolism" XP_046740568.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046747183.1 5 Reactome: R-HSA-211981;Reactome: R-HSA-8937144;Reactome: R-HSA-211945;Reactome: R-HSA-1989781;Reactome: R-HSA-211976 "Xenobiotics";"Aryl hydrocarbon receptor signalling";"Phase I - Functionalization of compounds";"PPARA activates gene expression";"Endogenous sterols" XP_046742910.1 2 Reactome: R-HSA-2142691;Reactome: R-HSA-2142700 "Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)" XP_046737335.1 1 Reactome: R-HSA-71288 "Creatine metabolism" XP_046743514.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046752447.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046742463.1 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" XP_046751977.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection" XP_046735907.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046749503.1 3 MetaCyc: PWY-4361;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23 "S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism" XP_046750529.1 2 Reactome: R-HSA-390471;Reactome: R-HSA-429958 "Association of TriC/CCT with target proteins during biosynthesis";"mRNA decay by 3' to 5' exoribonuclease" XP_046742439.1 2 Reactome: R-HSA-8936459;Reactome: R-HSA-3214841 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines" XP_046752356.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046750304.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046747542.1 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" XP_046751737.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046741578.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046751433.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046741198.1 10 Reactome: R-HSA-5693616;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-912446;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938 "Presynaptic phase of homologous DNA pairing and strand exchange";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Meiotic recombination";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)" XP_046737927.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046735049.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046737256.1 5 Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-983231;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878 "MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"Factors involved in megakaryocyte development and platelet production";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport" XP_046752287.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046746435.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046751774.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046739675.1 5 MetaCyc: PWY-5532;Reactome: R-HSA-73621;Reactome: R-HSA-73614;KEGG: 00240+2.4.2.3;KEGG: 00983+2.4.2.3 "Nucleoside and nucleotide degradation (archaea)";"Pyrimidine catabolism";"Pyrimidine salvage";"Pyrimidine metabolism";"Drug metabolism - other enzymes" XP_046738443.1 1 Reactome: R-HSA-6811438 "Intra-Golgi traffic" XP_046750836.1 1 Reactome: R-HSA-203615 "eNOS activation" XP_046736809.1 5 Reactome: R-HSA-5628897;Reactome: R-HSA-5625740;Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-75035 "TP53 Regulates Metabolic Genes";"RHO GTPases activate PKNs";"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" XP_046753800.1 17 Reactome: R-HSA-937042;Reactome: R-HSA-450302;Reactome: R-HSA-168638;Reactome: R-HSA-4086398;Reactome: R-HSA-445989;Reactome: R-HSA-450321;Reactome: R-HSA-975163;Reactome: R-HSA-9014325;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-9645460;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-5689880;Reactome: R-HSA-9020702;Reactome: R-HSA-5607764 "IRAK2 mediated activation of TAK1 complex";"activated TAK1 mediates p38 MAPK activation";"NOD1/2 Signaling Pathway";"Ca2+ pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Alpha-protein kinase 1 signaling pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"Ub-specific processing proteases";"Interleukin-1 signaling";"CLEC7A (Dectin-1) signaling" XP_046749523.1 16 Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339 "Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane" XP_046738540.1 27 Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-168276;Reactome: R-HSA-191859;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-4570464;Reactome: R-HSA-3108214;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-168325 "SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"NS1 Mediated Effects on Host Pathways";"snRNP Assembly";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis" XP_046742422.1 1 Reactome: R-HSA-1483148 "Synthesis of PG" XP_046736703.1 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" XP_046743879.1 24 Reactome: R-HSA-9619483;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-1445148;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-9648025;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-380320;Reactome: R-HSA-437239;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690 "Activation of AMPK downstream of NMDARs";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Aggrephagy";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-mediated anterograde transport";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"EML4 and NUDC in mitotic spindle formation";"Cilium Assembly";"Separation of Sister Chromatids";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"Recruitment of NuMA to mitotic centrosomes";"Recycling pathway of L1";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"HCMV Early Events" XP_046742489.1 2 Reactome: R-HSA-181429;Reactome: R-HSA-212676 "Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle" XP_046751647.1 8 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-437239 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Recycling pathway of L1" XP_046744316.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046733738.1 11 Reactome: R-HSA-2029482;Reactome: R-HSA-5693565;Reactome: R-HSA-525793;Reactome: R-HSA-8940973;Reactome: R-HSA-983231;Reactome: R-HSA-8939236;Reactome: R-HSA-5663213;Reactome: R-HSA-428890;Reactome: R-HSA-5685938;KEGG: 04660+2.7.10.2;Reactome: R-HSA-69231 "Regulation of actin dynamics for phagocytic cup formation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Myogenesis";"RUNX2 regulates osteoblast differentiation";"Factors involved in megakaryocyte development and platelet production";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RHO GTPases Activate WASPs and WAVEs";"Role of ABL in ROBO-SLIT signaling";"HDR through Single Strand Annealing (SSA)";"T cell receptor signaling pathway";"Cyclin D associated events in G1" XP_046753415.1 19 Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692;Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-9649948;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-438066;Reactome: R-HSA-5673000;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-6802952 "Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Signaling downstream of RAS mutants";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"RAF activation";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions" XP_046751966.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046737479.1 7 Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518 "Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2" XP_046747618.1 3 MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1 "Diethylphosphate degradation";"Thiamine metabolism";"Folate biosynthesis" XP_046740544.1 4 Reactome: R-HSA-446193;KEGG: 00510+2.4.1.260;KEGG: 00513+2.4.1.260;Reactome: R-HSA-4720489 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Defective ALG12 causes ALG12-CDG (CDG-1g)" XP_046745332.1 2 Reactome: R-HSA-525793;Reactome: R-HSA-390648 "Myogenesis";"Muscarinic acetylcholine receptors" XP_046748419.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046745525.1 4 Reactome: R-HSA-6814122;Reactome: R-HSA-202040;Reactome: R-HSA-112043;Reactome: R-HSA-418594 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G-protein activation";"PLC beta mediated events";"G alpha (i) signalling events" XP_046746234.1 3 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.20;Reactome: R-HSA-2408522 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism" XP_046735610.1 2 Reactome: R-HSA-5663213;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation" XP_046734767.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046749658.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046736019.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046738948.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046748795.1 16 Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-176407;Reactome: R-HSA-179409;Reactome: R-HSA-174084;Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-174048;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-176408;Reactome: R-HSA-176409;Reactome: R-HSA-174184 "APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC-Cdc20 mediated degradation of Nek2A";"Autodegradation of Cdh1 by Cdh1:APC/C";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"APC/C:Cdc20 mediated degradation of Cyclin B";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A" XP_046753347.1 19 Reactome: R-HSA-6802955;Reactome: R-HSA-5673001;Reactome: R-HSA-936837;Reactome: R-HSA-9022692;Reactome: R-HSA-6802946;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-438066;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-5673000;Reactome: R-HSA-442982;Reactome: R-HSA-399719 "Paradoxical activation of RAF signaling by kinase inactive BRAF";"RAF/MAP kinase cascade";"Ion transport by P-type ATPases";"Regulation of MECP2 expression and activity";"Signaling by moderate kinase activity BRAF mutants";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Unblocking of NMDA receptors, glutamate binding and activation";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"RAF activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors" XP_046734465.1 5 KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6317;MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6 "Galactose metabolism";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism" XP_046747186.1 5 Reactome: R-HSA-211976;Reactome: R-HSA-1989781;Reactome: R-HSA-8937144;Reactome: R-HSA-211945;Reactome: R-HSA-211981 "Endogenous sterols";"PPARA activates gene expression";"Aryl hydrocarbon receptor signalling";"Phase I - Functionalization of compounds";"Xenobiotics" XP_046740314.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" XP_046737131.1 2 KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557 "T cell receptor signaling pathway";"Signaling by SCF-KIT" XP_046736339.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046753271.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046742385.1 1 Reactome: R-HSA-400253 "Circadian Clock" XP_046741970.1 1 Reactome: R-HSA-901032 "ER Quality Control Compartment (ERQC)" XP_046737565.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046745674.1 2 KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753 "Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism" XP_046736595.1 17 Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693565;Reactome: R-HSA-5685942;Reactome: R-HSA-5693548;Reactome: R-HSA-5693616;Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;Reactome: R-HSA-5685938;Reactome: R-HSA-3270619;Reactome: R-HSA-5693554;Reactome: R-HSA-69473;Reactome: R-HSA-2559586;Reactome: R-HSA-5685939;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-912446 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDR through Homologous Recombination (HRR)";"Sensing of DNA Double Strand Breaks";"Presynaptic phase of homologous DNA pairing and strand exchange";"Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"HDR through Single Strand Annealing (SSA)";"IRF3-mediated induction of type I IFN";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"G2/M DNA damage checkpoint";"DNA Damage/Telomere Stress Induced Senescence";"HDR through MMEJ (alt-NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Meiotic recombination" XP_046734778.1 2 Reactome: R-HSA-8869496;Reactome: R-HSA-6790901 "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation";"rRNA modification in the nucleus and cytosol" XP_046747628.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-5357905 "RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling" XP_046736938.1 1 MetaCyc: PWY-7942 "5-oxo-L-proline metabolism" XP_046737840.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046749389.1 2 Reactome: R-HSA-389661;Reactome: R-HSA-2408508 "Glyoxylate metabolism and glycine degradation";"Metabolism of ingested SeMet, Sec, MeSec into H2Se" XP_046746963.1 7 KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046749827.1 3 KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029;MetaCyc: PWY-7221 "Purine metabolism";"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis" XP_046742273.1 1 Reactome: R-HSA-428359 "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" XP_046738501.1 42 Reactome: R-HSA-5334118;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-3214847;Reactome: R-HSA-5693571;Reactome: R-HSA-3214815;Reactome: R-HSA-212300;Reactome: R-HSA-9018519;Reactome: R-HSA-2299718;Reactome: R-HSA-171306;Reactome: R-HSA-110328;Reactome: R-HSA-69473;Reactome: R-HSA-9609690;Reactome: R-HSA-110330;Reactome: R-HSA-5625886;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-73728;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-73772;Reactome: R-HSA-5693565;Reactome: R-HSA-4551638;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-2559582;Reactome: R-HSA-2559580;Reactome: R-HSA-5578749;Reactome: R-HSA-5617472;Reactome: R-HSA-3214842;Reactome: R-HSA-427413;Reactome: R-HSA-8936459;Reactome: R-HSA-3214858;Reactome: R-HSA-1221632;Reactome: R-HSA-427359;Reactome: R-HSA-2559586;Reactome: R-HSA-1912408;Reactome: R-HSA-977225;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-606279;Reactome: R-HSA-9610379 "DNA methylation";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"HATs acetylate histones";"Nonhomologous End-Joining (NHEJ)";"HDACs deacetylate histones";"PRC2 methylates histones and DNA";"Estrogen-dependent gene expression";"Condensation of Prophase Chromosomes";"Packaging Of Telomere Ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"G2/M DNA damage checkpoint";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected purine";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"RNA Polymerase I Promoter Opening";"Processing of DNA double-strand break ends";"Meiotic recombination";"RNA Polymerase I Promoter Escape";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"SUMOylation of chromatin organization proteins";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Senescence-Associated Secretory Phenotype (SASP)";"Oxidative Stress Induced Senescence";"Transcriptional regulation by small RNAs";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HDMs demethylate histones";"NoRC negatively regulates rRNA expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RMTs methylate histone arginines";"Meiotic synapsis";"SIRT1 negatively regulates rRNA expression";"DNA Damage/Telomere Stress Induced Senescence";"Pre-NOTCH Transcription and Translation";"Amyloid fiber formation";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere";"HCMV Late Events" XP_046736314.1 4 Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-419037 "Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"NCAM1 interactions" XP_046752564.1 2 MetaCyc: PWY-7802;MetaCyc: PWY-7799 "N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)" XP_046741914.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046736556.1 3 MetaCyc: PWY-5691;KEGG: 00230+1.7.3.3;KEGG: 00232+1.7.3.3 "Urate conversion to allantoin I";"Purine metabolism";"Caffeine metabolism" XP_046750948.1 2 Reactome: R-HSA-6785470;Reactome: R-HSA-6784531 "tRNA processing in the mitochondrion";"tRNA processing in the nucleus" XP_046736841.1 13 Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689 "Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits" XP_046739472.1 13 Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9633012 "L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046744584.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046748371.1 9 Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607 "HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends" XP_046745489.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046737313.1 14 MetaCyc: PWY-7782;KEGG: 00565+3.1.3.4;Reactome: R-HSA-4419969;MetaCyc: PWY-8055;MetaCyc: PWY-8053;Reactome: R-HSA-1483213;KEGG: 00564+3.1.3.4;KEGG: 00600+3.1.3.4;MetaCyc: PWY-8052;MetaCyc: PWY-6453;MetaCyc: PWY-8051;Reactome: R-HSA-75109;KEGG: 00561+3.1.3.4;Reactome: R-HSA-1483191 "Plasmalogen biosynthesis";"Ether lipid metabolism";"Depolymerisation of the Nuclear Lamina";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"Synthesis of PE";"Glycerophospholipid metabolism";"Sphingolipid metabolism";"2-arachidonoylglycerol biosynthesis";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Triglyceride biosynthesis";"Glycerolipid metabolism";"Synthesis of PC" XP_046740134.1 2 Reactome: R-HSA-8986944;Reactome: R-HSA-203927 "Transcriptional Regulation by MECP2";"MicroRNA (miRNA) biogenesis" XP_046752043.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046735572.1 9 Reactome: R-HSA-2173791;Reactome: R-HSA-2173789;Reactome: R-HSA-3304356;Reactome: R-HSA-3645790;Reactome: R-HSA-3642279;Reactome: R-HSA-5689603;Reactome: R-HSA-3656532;Reactome: R-HSA-3656535;Reactome: R-HSA-2173788 "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGF-beta receptor signaling activates SMADs";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR2 Kinase Domain Mutants in Cancer";"TGFBR2 MSI Frameshift Mutants in Cancer";"UCH proteinases";"TGFBR1 KD Mutants in Cancer";"TGFBR1 LBD Mutants in Cancer";"Downregulation of TGF-beta receptor signaling" XP_046741151.1 3 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" XP_046753276.1 2 MetaCyc: PWY-6558;Reactome: R-HSA-2022928 "Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis" XP_046740541.1 4 Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823 "Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex" XP_046747633.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-5357905 "RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling" XP_046737716.1 1 Reactome: R-HSA-114608 "Platelet degranulation" XP_046733875.1 6 KEGG: 00562+3.1.3.66;Reactome: R-HSA-1855183;Reactome: R-HSA-1660516;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.66;MetaCyc: PWY-6368 "Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation" XP_046744288.1 12 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic" XP_046740561.1 2 Reactome: R-HSA-71336;KEGG: 00710+2.7.1.14 "Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms" XP_046736594.1 1 Reactome: R-HSA-9603798 "Class I peroxisomal membrane protein import" XP_046747417.1 6 Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72689 "GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits" XP_046753881.1 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" XP_046735792.1 2 Reactome: R-HSA-70895;KEGG: 00280+1.1.1.31 "Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation" XP_046747902.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046749348.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046749986.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" XP_046751346.1 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" XP_046743087.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046734394.1 1 Reactome: R-HSA-9616222 "Transcriptional regulation of granulopoiesis" XP_046735654.1 3 Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation" XP_046735636.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046751627.1 1 Reactome: R-HSA-69273 "Cyclin A/B1/B2 associated events during G2/M transition" XP_046750787.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046735724.1 7 Reactome: R-HSA-5628897;KEGG: 00220+3.5.1.2;Reactome: R-HSA-8964539;MetaCyc: PWY-5921;Reactome: R-HSA-210500;KEGG: 00471+3.5.1.2;KEGG: 00250+3.5.1.2 "TP53 Regulates Metabolic Genes";"Arginine biosynthesis";"Glutamate and glutamine metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate Neurotransmitter Release Cycle";"D-Glutamine and D-glutamate metabolism";"Alanine, aspartate and glutamate metabolism" XP_046747644.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046740988.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046753014.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046745063.1 2 Reactome: R-HSA-5205685;Reactome: R-HSA-1268020 "Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import" XP_046738798.1 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" XP_046744718.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046744196.1 12 Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257 "RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion" XP_046739678.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046750189.1 1 Reactome: R-HSA-418886 "Netrin mediated repulsion signals" XP_046740095.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046750755.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046751770.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046751495.1 3 Reactome: R-HSA-70268;KEGG: 00620+4.4.1.5;MetaCyc: PWY-5386 "Pyruvate metabolism";"Pyruvate metabolism";"Methylglyoxal degradation I" XP_046749396.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes" XP_046742143.1 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" XP_046734293.1 2 Reactome: R-HSA-382556;Reactome: R-HSA-5678895 "ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis" XP_046751515.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046744587.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046743337.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046734790.1 57 Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-5676590;Reactome: R-HSA-5607761;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-1236974;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949 "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"NIK-->noncanonical NF-kB signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"ER-Phagosome pathway";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"UCH proteinases";"Hedgehog 'on' state";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin" XP_046740317.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046744013.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046733905.1 14 MetaCyc: PWY-181;MetaCyc: PWY-3841;MetaCyc: PWY-2201;MetaCyc: PWY-1622;KEGG: 00630+2.1.2.1;MetaCyc: PWY-2161;KEGG: 00260+2.1.2.1;KEGG: 00460+2.1.2.1;KEGG: 00670+2.1.2.1;MetaCyc: PWY-3661;MetaCyc: PWY-5497;Reactome: R-HSA-196757;MetaCyc: PWY-3661-1;KEGG: 00680+2.1.2.1 "Photorespiration ";"Folate transformations II (plants)";"Folate transformations I";"Formaldehyde assimilation I (serine pathway)";"Glyoxylate and dicarboxylate metabolism";"Folate polyglutamylation";"Glycine, serine and threonine metabolism";"Cyanoamino acid metabolism";"One carbon pool by folate";"Glycine betaine degradation I";"Purine nucleobases degradation II (anaerobic)";"Metabolism of folate and pterines";"Glycine betaine degradation II (mammalian)";"Methane metabolism" XP_046745059.1 2 Reactome: R-HSA-8854214;Reactome: R-HSA-977225 "TBC/RABGAPs";"Amyloid fiber formation" XP_046740480.1 3 MetaCyc: PWY-8099;MetaCyc: PWY-7158;KEGG: 00790+4.2.1.96 "Tetrahydropteridine recycling";"L-phenylalanine degradation V";"Folate biosynthesis" XP_046747661.1 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" XP_046746789.1 19 Reactome: R-HSA-8856828;Reactome: R-HSA-381426;Reactome: R-HSA-8856825;Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-3000497;Reactome: R-HSA-8963901;Reactome: R-HSA-8964046;Reactome: R-HSA-3000480;Reactome: R-HSA-8963888;Reactome: R-HSA-3000484;Reactome: R-HSA-8957275;Reactome: R-HSA-8964041;Reactome: R-HSA-8964026;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471;Reactome: R-HSA-202733;Reactome: R-HSA-975634;Reactome: R-HSA-8964038 "Clathrin-mediated endocytosis";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Cargo recognition for clathrin-mediated endocytosis";"Platelet sensitization by LDL";"VLDL assembly";"Scavenging by Class H Receptors";"Chylomicron remodeling";"VLDL clearance";"Scavenging by Class A Receptors";"Chylomicron assembly";"Scavenging by Class F Receptors";"Post-translational protein phosphorylation";"LDL remodeling";"Chylomicron clearance";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors";"Cell surface interactions at the vascular wall";"Retinoid metabolism and transport";"LDL clearance" XP_046738577.1 3 Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148 "Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046752022.1 5 Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-917977 "ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Ion channel transport";"Transferrin endocytosis and recycling" XP_046750826.1 7 MetaCyc: PWY-5084;KEGG: 00020+2.3.1.61;Reactome: R-HSA-71064;Reactome: R-HSA-71403;Reactome: R-HSA-389661;KEGG: 00310+2.3.1.61;KEGG: 00380+2.3.1.61 "2-oxoglutarate decarboxylation to succinyl-CoA";"Citrate cycle (TCA cycle)";"Lysine catabolism";"Citric acid cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"Tryptophan metabolism" XP_046737698.1 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" XP_046744741.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046751365.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046740547.1 4 KEGG: 00513+2.4.1.260;KEGG: 00510+2.4.1.260;Reactome: R-HSA-446193;Reactome: R-HSA-4720489 "Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG12 causes ALG12-CDG (CDG-1g)" XP_046739330.1 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" XP_046737217.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046734508.1 8 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Signaling by Hippo";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection" XP_046744817.1 5 Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-73762;Reactome: R-HSA-8943724;Reactome: R-HSA-6804758 "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"RNA Polymerase I Transcription Initiation";"Regulation of PTEN gene transcription";"Regulation of TP53 Activity through Acetylation" XP_046753618.1 13 Reactome: R-HSA-2871837;Reactome: R-HSA-9645460;Reactome: R-HSA-937042;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-450302;Reactome: R-HSA-168638;Reactome: R-HSA-445989;Reactome: R-HSA-450321;Reactome: R-HSA-975163;Reactome: R-HSA-5607764;Reactome: R-HSA-9020702;Reactome: R-HSA-9014325 "FCERI mediated NF-kB activation";"Alpha-protein kinase 1 signaling pathway";"IRAK2 mediated activation of TAK1 complex";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"activated TAK1 mediates p38 MAPK activation";"NOD1/2 Signaling Pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"CLEC7A (Dectin-1) signaling";"Interleukin-1 signaling";"TICAM1,TRAF6-dependent induction of TAK1 complex" XP_046734486.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046750644.1 7 Reactome: R-HSA-5358346;Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-381038;Reactome: R-HSA-5362768;Reactome: R-HSA-901032;Reactome: R-HSA-8951664 "Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"XBP1(S) activates chaperone genes";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ER Quality Control Compartment (ERQC)";"Neddylation" XP_046753679.1 7 Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-6783310;Reactome: R-HSA-5685938;Reactome: R-HSA-176187;Reactome: R-HSA-69473 "Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"Fanconi Anemia Pathway";"HDR through Single Strand Annealing (SSA)";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint" XP_046745814.1 2 Reactome: R-HSA-5689880;Reactome: R-HSA-5689603 "Ub-specific processing proteases";"UCH proteinases" XP_046738172.1 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" XP_046744824.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046742552.1 7 Reactome: R-HSA-5633231;MetaCyc: PWY-6385;MetaCyc: PWY-5265;KEGG: 00550+2.4.1.227;Reactome: R-HSA-446193;MetaCyc: PWY-6471;MetaCyc: PWY-6470 "Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Peptidoglycan biosynthesis III (mycobacteria)";"Peptidoglycan biosynthesis II (staphylococci)";"Peptidoglycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Peptidoglycan biosynthesis V (beta-lactam resistance)" XP_046753726.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046740091.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046752516.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-430039 "mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease" XP_046752545.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046742604.1 2 Reactome: R-HSA-5696394;Reactome: R-HSA-5689603 "DNA Damage Recognition in GG-NER";"UCH proteinases" XP_046753192.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046743035.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046749291.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046735801.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046737579.1 2 Reactome: R-HSA-1660662;Reactome: R-HSA-390471 "Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis" XP_046739748.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046752560.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046736103.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046735298.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046742938.1 1 Reactome: R-HSA-201681 "TCF dependent signaling in response to WNT" XP_046734143.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046736696.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046749227.1 4 Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402 "Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex" XP_046741951.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046748473.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046740997.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046743662.1 5 KEGG: 00250+6.3.5.4;Reactome: R-HSA-9648895;Reactome: R-HSA-8963693;Reactome: R-HSA-380994;Reactome: R-HSA-9633012 "Alanine, aspartate and glutamate metabolism";"Response of EIF2AK1 (HRI) to heme deficiency";"Aspartate and asparagine metabolism";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046749969.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" XP_046741003.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046745519.1 4 MetaCyc: PWY-7268;MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49;KEGG: 00480+1.1.1.49 "NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Entner-Doudoroff pathway I";"Pentose phosphate pathway";"Glutathione metabolism" XP_046747830.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046736378.1 2 Reactome: R-HSA-2173788;Reactome: R-HSA-5689603 "Downregulation of TGF-beta receptor signaling";"UCH proteinases" XP_046745009.1 6 Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease" XP_046736101.1 2 Reactome: R-HSA-3238698;Reactome: R-HSA-373080 "WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)" XP_046738725.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046737757.1 7 Reactome: R-HSA-201688;Reactome: R-HSA-4086400;Reactome: R-HSA-4641258;Reactome: R-HSA-201681;Reactome: R-HSA-4641262;Reactome: R-HSA-5368598;Reactome: R-HSA-5663220 "WNT mediated activation of DVL";"PCP/CE pathway";"Degradation of DVL";"TCF dependent signaling in response to WNT";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"RHO GTPases Activate Formins" XP_046736509.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046738136.1 8 Reactome: R-HSA-180024;Reactome: R-HSA-432040;Reactome: R-HSA-442720;Reactome: R-HSA-163615;Reactome: R-HSA-983231;Reactome: R-HSA-381676;Reactome: R-HSA-5610787;Reactome: R-HSA-164378 "DARPP-32 events";"Vasopressin regulates renal water homeostasis via Aquaporins";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"PKA activation";"Factors involved in megakaryocyte development and platelet production";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Hedgehog 'off' state";"PKA activation in glucagon signalling" XP_046738969.1 4 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.18;Reactome: R-HSA-2408522;Reactome: R-HSA-379726 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation" XP_046740361.1 2 Reactome: R-HSA-8949215;Reactome: R-HSA-983231 "Mitochondrial calcium ion transport";"Factors involved in megakaryocyte development and platelet production" XP_046743791.1 3 Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-430039 "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease" XP_046740776.1 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" XP_046743838.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046743334.1 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046735289.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046742000.1 2 Reactome: R-HSA-5601884;Reactome: R-HSA-1221632 "PIWI-interacting RNA (piRNA) biogenesis";"Meiotic synapsis" XP_046734078.1 1 Reactome: R-HSA-350562 "Regulation of ornithine decarboxylase (ODC)" XP_046743157.1 3 Reactome: R-HSA-948021;Reactome: R-HSA-204005;Reactome: R-HSA-5694530 "Transport to the Golgi and subsequent modification";"COPII-mediated vesicle transport";"Cargo concentration in the ER" XP_046751985.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046737331.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046752360.1 7 KEGG: 00230+2.4.2.7;MetaCyc: PWY-6605;Reactome: R-HSA-6798695;Reactome: R-HSA-74217;MetaCyc: PWY-7805;MetaCyc: PWY-7807;MetaCyc: PWY-6610 "Purine metabolism";"Adenine and adenosine salvage II";"Neutrophil degranulation";"Purine salvage";"(aminomethyl)phosphonate degradation";"Glyphosate degradation III";"Adenine salvage" XP_046741248.1 4 Reactome: R-HSA-352230;Reactome: R-HSA-210991;Reactome: R-HSA-5660862;Reactome: R-HSA-71240 "Amino acid transport across the plasma membrane";"Basigin interactions";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)";"Tryptophan catabolism" XP_046749859.1 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" XP_046739219.1 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" XP_046749647.1 1 Reactome: R-HSA-5689901 "Metalloprotease DUBs" XP_046734588.1 7 KEGG: 04070+3.1.3.25;Reactome: R-HSA-1855183;MetaCyc: PWY-2301;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.25;KEGG: 00521+3.1.3.25;MetaCyc: PWY-4702 "Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism";"Streptomycin biosynthesis";"Phytate degradation I" XP_046748461.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046741023.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046746064.1 17 Reactome: R-HSA-5685938;Reactome: R-HSA-6796648;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693616;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3371453;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-1221632;KEGG: 05163+2.7.11.1;Reactome: R-HSA-69473;KEGG: 04714+2.7.11.1;Reactome: R-HSA-176187;Reactome: R-HSA-6783310;KEGG: 04151+2.7.11.1 "HDR through Single Strand Annealing (SSA)";"TP53 Regulates Transcription of DNA Repair Genes";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Presynaptic phase of homologous DNA pairing and strand exchange";"mTOR signaling pathway";"Regulation of HSF1-mediated heat shock response";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Meiotic synapsis";"Human cytomegalovirus infection";"G2/M DNA damage checkpoint";"Thermogenesis";"Activation of ATR in response to replication stress";"Fanconi Anemia Pathway";"PI3K-Akt signaling pathway" XP_046748623.1 5 KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527 "Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism";"Glycerolipid metabolism";"Stachyose degradation" XP_046743931.1 12 MetaCyc: PWY-6527;Reactome: R-HSA-3322077;Reactome: R-HSA-173599;KEGG: 00520+2.7.7.9;KEGG: 00040+2.7.7.9;MetaCyc: PWY-7238;KEGG: 00052+2.7.7.9;MetaCyc: PWY-7817;MetaCyc: PWY-7343;KEGG: 00500+2.7.7.9;KEGG: 00561+2.7.7.9;MetaCyc: PWY-3801 "Stachyose degradation";"Glycogen synthesis";"Formation of the active cofactor, UDP-glucuronate";"Amino sugar and nucleotide sugar metabolism";"Pentose and glucuronate interconversions";"Sucrose biosynthesis II";"Galactose metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"UDP-alpha-D-glucose biosynthesis I";"Starch and sucrose metabolism";"Glycerolipid metabolism";"Sucrose degradation II (sucrose synthase)" XP_046752882.1 5 Reactome: R-HSA-390450;Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-6814122 "Folding of actin by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" XP_046744018.1 4 Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" XP_046734774.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046734591.1 16 Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-156902 "L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation" XP_046737880.1 4 KEGG: 00564+3.1.1.32;KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803 "Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing" XP_046733911.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046736057.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046743391.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-8866654 "Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046735902.1 6 MetaCyc: PWY-7817;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039 "Type I lipoteichoic acid biosynthesis (S. aureus)";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule" XP_046736568.1 4 KEGG: 00908+2.5.1.75;Reactome: R-HSA-6787450;MetaCyc: PWY-2781;Reactome: R-HSA-6782315 "Zeatin biosynthesis";"tRNA modification in the mitochondrion";"Cis-zeatin biosynthesis";"tRNA modification in the nucleus and cytosol" XP_046742136.1 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" XP_046737044.1 2 Reactome: R-HSA-373080;Reactome: R-HSA-3238698 "Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking" XP_046734691.1 3 Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046745021.1 7 Reactome: R-HSA-76061;Reactome: R-HSA-1834949;Reactome: R-HSA-73780;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-76071 "RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" XP_046737630.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046753427.1 5 MetaCyc: PWY-7269;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23 "NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism" XP_046749760.1 7 Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-165159;Reactome: R-HSA-1632852 "Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"mTOR signalling";"Macroautophagy" XP_046738147.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046740952.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046752738.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046739629.1 4 Reactome: R-HSA-6782861;MetaCyc: PWY-6829;MetaCyc: PWY-7285;MetaCyc: PWY-7286 "Synthesis of wybutosine at G37 of tRNA(Phe)";"Trna methylation (yeast)";"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis" XP_046749300.1 5 Reactome: R-HSA-6807004;Reactome: R-HSA-8875360;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-182971 "Negative regulation of MET activity";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"EGFR downregulation" XP_046745754.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-6807505 "mRNA Splicing - Major Pathway";"RNA polymerase II transcribes snRNA genes" XP_046734358.1 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" XP_046753358.1 5 Reactome: R-HSA-168638;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;Reactome: R-HSA-376172;KEGG: 04150+2.7.11.24 "NOD1/2 Signaling Pathway";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"DSCAM interactions";"mTOR signaling pathway" XP_046737425.1 2 Reactome: R-HSA-383280;Reactome: R-HSA-983231 "Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production" XP_046745349.1 2 Reactome: R-HSA-8853659;Reactome: R-HSA-5673001 "RET signaling";"RAF/MAP kinase cascade" XP_046749456.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex" XP_046746087.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046742135.1 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" XP_046746840.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046745873.1 4 Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3 "Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism";"Purine metabolism" XP_046749071.1 5 Reactome: R-HSA-2426168;Reactome: R-HSA-191273;MetaCyc: PWY-922;KEGG: 00900+2.7.4.2;MetaCyc: PWY-7391 "Activation of gene expression by SREBF (SREBP)";"Cholesterol biosynthesis";"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Isoprene biosynthesis II (engineered)" XP_046751697.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046747412.1 182 Reactome: R-HSA-8941858;Reactome: R-HSA-2644606;Reactome: R-HSA-6782210;Reactome: R-HSA-182971;Reactome: R-HSA-2173791;Reactome: R-HSA-168638;Reactome: R-HSA-180534;Reactome: R-HSA-168927;Reactome: R-HSA-8852276;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-1253288;Reactome: R-HSA-9020702;Reactome: R-HSA-5689896;Reactome: R-HSA-5357905;Reactome: R-HSA-187577;Reactome: R-HSA-975163;Reactome: R-HSA-450321;Reactome: R-HSA-9013507;Reactome: R-HSA-450408;Reactome: R-HSA-6807004;Reactome: R-HSA-4641257;Reactome: R-HSA-5675221;Reactome: R-HSA-72649;Reactome: R-HSA-8876493;Reactome: R-HSA-912631;Reactome: R-HSA-917729;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-211733;Reactome: R-HSA-1799339;Reactome: R-HSA-5610783;Reactome: R-HSA-2173795;Reactome: R-HSA-6804757;Reactome: R-HSA-8939902;Reactome: R-HSA-5693565;Reactome: R-HSA-9633012;Reactome: R-HSA-2122947;Reactome: R-HSA-8948751;Reactome: R-HSA-2559580;Reactome: R-HSA-69231;Reactome: R-HSA-174048;Reactome: R-HSA-5655862;Reactome: R-HSA-69541;Reactome: R-HSA-1236974;Reactome: R-HSA-75815;Reactome: R-HSA-937042;Reactome: R-HSA-6804756;Reactome: R-HSA-901032;Reactome: R-HSA-937041;Reactome: R-HSA-6791226;Reactome: R-HSA-5358346;Reactome: R-HSA-9637628;Reactome: R-HSA-5656121;Reactome: R-HSA-110312;Reactome: R-HSA-3769402;Reactome: R-HSA-400253;Reactome: R-HSA-975956;Reactome: R-HSA-2173796;Reactome: R-HSA-8866654;Reactome: R-HSA-9645460;Reactome: R-HSA-983168;Reactome: R-HSA-4641263;Reactome: R-HSA-6781827;Reactome: R-HSA-68949;Reactome: R-HSA-9014325;Reactome: R-HSA-2672351;Reactome: R-HSA-179409;Reactome: R-HSA-5675482;Reactome: R-HSA-2691232;Reactome: R-HSA-1236382;Reactome: R-HSA-2173788;Reactome: R-HSA-5684264;Reactome: R-HSA-532668;Reactome: R-HSA-156902;Reactome: R-HSA-5687128;Reactome: R-HSA-2559585;Reactome: R-HSA-72706;Reactome: R-HSA-5205685;Reactome: R-HSA-5607764;Reactome: R-HSA-2408557;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-975144;Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-5654727;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-9013973;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684;Reactome: R-HSA-6783310;Reactome: R-HSA-5693607;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-936964;Reactome: R-HSA-72695;Reactome: R-HSA-6781823;Reactome: R-HSA-5610780;Reactome: R-HSA-205043;Reactome: R-HSA-5654733;Reactome: R-HSA-3134975;Reactome: R-HSA-975110;Reactome: R-HSA-8948747;Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-2565942;Reactome: R-HSA-3322077;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-4641258;Reactome: R-HSA-69601;Reactome: R-HSA-5696400;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-1358803;Reactome: R-HSA-5689877;Reactome: R-HSA-936440;Reactome: R-HSA-977225;Reactome: R-HSA-8854050;Reactome: R-HSA-917937;Reactome: R-HSA-6804760;Reactome: R-HSA-8875360;Reactome: R-HSA-174184;Reactome: R-HSA-175474;Reactome: R-HSA-110314;Reactome: R-HSA-5678895;Reactome: R-HSA-5685942;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-2559582;Reactome: R-HSA-209543;Reactome: R-HSA-5689901;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-9613829;Reactome: R-HSA-2894862;Reactome: R-HSA-450302;Reactome: R-HSA-168928;Reactome: R-HSA-9636383;Reactome: R-HSA-192823;Reactome: R-HSA-201681;Reactome: R-HSA-1169408;Reactome: R-HSA-5696395;Reactome: R-HSA-5362768;Reactome: R-HSA-5607761;Reactome: R-HSA-8863795;Reactome: R-HSA-156827;Reactome: R-HSA-8866652;Reactome: R-HSA-5357956;Reactome: R-HSA-69017;Reactome: R-HSA-209560;Reactome: R-HSA-9033241;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-975957;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-2979096;Reactome: R-HSA-110320;Reactome: R-HSA-445989;Reactome: R-HSA-937039;Reactome: R-HSA-162588;Reactome: R-HSA-382556;Reactome: R-HSA-5658442;Reactome: R-HSA-1295596;Reactome: R-HSA-5654726;Reactome: R-HSA-5696397;Reactome: R-HSA-8939236;Reactome: R-HSA-5696394;Reactome: R-HSA-195253;Reactome: R-HSA-8856828;Reactome: R-HSA-3785653;Reactome: R-HSA-2122948;Reactome: R-HSA-5654732;Reactome: R-HSA-937072;Reactome: R-HSA-8856825;Reactome: R-HSA-72702;Reactome: R-HSA-8849469;Reactome: R-HSA-9646399 "Regulation of RUNX3 expression and activity";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Gap-filling DNA repair synthesis and ligation in TC-NER";"EGFR downregulation";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"NOD1/2 Signaling Pathway";"Vpu mediated degradation of CD4";"TICAM1, RIP1-mediated IKK complex recruitment";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Downregulation of ERBB4 signaling";"Interleukin-1 signaling";"Ovarian tumor domain proteases";"Regulation of TNFR1 signaling";"SCF(Skp2)-mediated degradation of p27/p21";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Negative regulation of MET activity";"Degradation of AXIN";"Negative regulation of MAPK pathway";"Translation initiation complex formation";"InlA-mediated entry of Listeria monocytogenes into host cells";"Regulation of signaling by CBL";"Endosomal Sorting Complex Required For Transport (ESCRT)";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SRP-dependent cotranslational protein targeting to membrane";"Degradation of GLI2 by the proteasome";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Regulation of TP53 Degradation";"Regulation of RUNX2 expression and activity";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of PTEN stability and activity";"Oxidative Stress Induced Senescence";"Cyclin D associated events in G1";"APC/C:Cdc20 mediated degradation of Cyclin B";"Translesion synthesis by POLK";"Stabilization of p53";"ER-Phagosome pathway";"Ubiquitin-dependent degradation of Cyclin D";"IRAK2 mediated activation of TAK1 complex";"Regulation of TP53 Activity through Phosphorylation";"ER Quality Control Compartment (ERQC)";"IKK complex recruitment mediated by RIP1";"Major pathway of rRNA processing in the nucleolus and cytosol";"Hedgehog ligand biogenesis";"Modulation by Mtb of host immune system";"Translesion synthesis by POLI";"Translesion synthesis by REV1";"Deactivation of the beta-catenin transactivating complex";"Circadian Clock";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"E3 ubiquitin ligases ubiquitinate target proteins";"Alpha-protein kinase 1 signaling pathway";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of FZD by ubiquitination";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Orc1 removal from chromatin";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Stimuli-sensing channels";"APC-Cdc20 mediated degradation of Nek2A";"Regulation of necroptotic cell death";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Downregulation of TGF-beta receptor signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Peptide chain elongation";"MAPK6/MAPK4 signaling";"Oncogene Induced Senescence";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Pink/Parkin Mediated Mitophagy";"CLEC7A (Dectin-1) signaling";"Selenocysteine synthesis";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"Negative regulation of FGFR2 signaling";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"TICAM1-dependent activation of IRF3/IRF7";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state";"Fanconi Anemia Pathway";"Processing of DNA double-strand break ends";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of TC-NER Pre-Incision Complex";"Degradation of GLI1 by the proteasome";"NRIF signals cell death from the nucleus";"Negative regulation of FGFR4 signaling";"Regulation of innate immune responses to cytosolic DNA";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"Regulation of PTEN localization";"NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of PLK1 Activity at G2/M Transition";"Glycogen synthesis";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Degradation of DVL";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Dual Incision in GG-NER";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Downregulation of ERBB2:ERBB3 signaling";"Josephin domain DUBs";"Negative regulators of DDX58/IFIH1 signaling";"Amyloid fiber formation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Iron uptake and transport";"Regulation of TP53 Activity through Methylation";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Assembly Of The HIV Virion";"Recognition of DNA damage by PCNA-containing replication complex";"Defective CFTR causes cystic fibrosis";"HDR through Homologous Recombination (HRR)";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Senescence-Associated Secretory Phenotype (SASP)";"p75NTR recruits signalling complexes";"Metalloprotease DUBs";"Asymmetric localization of PCP proteins";"UCH proteinases";"Chaperone Mediated Autophagy";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"activated TAK1 mediates p38 MAPK activation";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Prevention of phagosomal-lysosomal fusion";"Viral mRNA Translation";"TCF dependent signaling in response to WNT";"ISG15 antiviral mechanism";"Formation of Incision Complex in GG-NER";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Dectin-1 mediated noncanonical NF-kB signaling";"Downregulation of ERBB2 signaling";"L13a-mediated translational silencing of Ceruloplasmin expression";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"TNFR1-induced NFkappaB signaling pathway";"CDK-mediated phosphorylation and removal of Cdc6";"NF-kB is activated and signals survival";"Peroxisomal protein import";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Translesion Synthesis by POLH";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"IRAK1 recruits IKK complex";"Budding and maturation of HIV virion";"ABC-family proteins mediated transport";"Regulation of RAS by GAPs";"Spry regulation of FGF signaling";"Negative regulation of FGFR1 signaling";"Gap-filling DNA repair synthesis and ligation in GG-NER";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"DNA Damage Recognition in GG-NER";"Degradation of beta-catenin by the destruction complex";"Clathrin-mediated endocytosis";"Myoclonic epilepsy of Lafora";"Activated NOTCH1 Transmits Signal to the Nucleus";"Negative regulation of FGFR3 signaling";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Cargo recognition for clathrin-mediated endocytosis";"Ribosomal scanning and start codon recognition";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"Aggrephagy" XP_046737011.1 13 Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination" XP_046749231.1 4 Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-3769402 "Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex" XP_046743888.1 3 Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382 "RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex" XP_046736902.1 4 Reactome: R-HSA-209931;KEGG: 00790+1.14.16.4;KEGG: 00380+1.14.16.4;MetaCyc: PWY-6030 "Serotonin and melatonin biosynthesis";"Folate biosynthesis";"Tryptophan metabolism";"Serotonin and melatonin biosynthesis" XP_046749065.1 4 MetaCyc: PWY-6482;MetaCyc: PWY-7546;Reactome: R-HSA-8849175;Reactome: R-HSA-5358493 "Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)";"Threonine catabolism";"Synthesis of diphthamide-EEF2" XP_046737824.1 1 Reactome: R-HSA-163765 "ChREBP activates metabolic gene expression" XP_046752902.1 5 MetaCyc: PWY-6168;KEGG: 00740+2.7.1.26;MetaCyc: PWY-5523;MetaCyc: PWY-7863;Reactome: R-HSA-196843 "Flavin biosynthesis III (fungi)";"Riboflavin metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Roseoflavin biosynthesis";"Vitamin B2 (riboflavin) metabolism" XP_046737191.1 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" XP_046742481.1 13 Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689 "Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits" XP_046740202.1 12 MetaCyc: PWY-601;MetaCyc: PWY-6842;Reactome: R-HSA-71240;KEGG: 00450+4.4.1.13;KEGG: 00270+4.4.1.13;KEGG: 00380+2.6.1.7;MetaCyc: PWY-6309;MetaCyc: PWY-2821;MetaCyc: PWY-801;MetaCyc: PWY-1187;MetaCyc: PWY-6936;MetaCyc: PWY-7901 "Glucosinolate biosynthesis from tryptophan";"Glutathione-mediated detoxification II";"Tryptophan catabolism";"Selenocompound metabolism";"Cysteine and methionine metabolism";"Tryptophan metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glucosinolate biosynthesis from phenylalanine";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from homomethionine";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from tyrosine" XP_046742683.1 16 Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226 "SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Peptide chain elongation";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046734781.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046733703.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046747696.1 2 Reactome: R-HSA-1369007;Reactome: R-HSA-5683371 "Mitochondrial ABC transporters";"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)" XP_046734361.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046735940.1 1 Reactome: R-HSA-1483166 "Synthesis of PA" XP_046739522.1 3 Reactome: R-HSA-6798695;Reactome: R-HSA-6794361;Reactome: R-HSA-264870 "Neutrophil degranulation";"Neurexins and neuroligins";"Caspase-mediated cleavage of cytoskeletal proteins" XP_046735725.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046742105.1 19 Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-5368286;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-5389840;Reactome: R-HSA-1799339;Reactome: R-HSA-5419276;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702 "Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Mitochondrial translation initiation";"Eukaryotic Translation Termination";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Mitochondrial translation elongation";"SRP-dependent cotranslational protein targeting to membrane";"Mitochondrial translation termination";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition" XP_046751414.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" XP_046745342.1 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" XP_046742244.1 2 KEGG: 00380+1.13.11.11;Reactome: R-HSA-71240 "Tryptophan metabolism";"Tryptophan catabolism" XP_046745039.1 2 Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" XP_046744755.1 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" XP_046743160.1 3 Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691 "Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)" XP_046747901.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046753955.1 4 Reactome: R-HSA-5689603;Reactome: R-HSA-3214847;MetaCyc: PWY-7437;KEGG: 00514+2.4.1.255 "UCH proteinases";"HATs acetylate histones";"Protein O-[N-acetyl]-glucosylation";"Other types of O-glycan biosynthesis" XP_046747011.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046741611.1 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" XP_046747617.1 4 Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-8856828;Reactome: R-HSA-5663213 "Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis";"RHO GTPases Activate WASPs and WAVEs" XP_046745796.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046742807.1 2 Reactome: R-HSA-975577;Reactome: R-HSA-2022854 "N-Glycan antennae elongation";"Keratan sulfate biosynthesis" XP_046744439.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-6803157 "Neutrophil degranulation";"Antimicrobial peptides" XP_046737413.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression" XP_046738988.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046737779.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046736160.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046740878.1 2 KEGG: 00280+1.3.8.4;Reactome: R-HSA-70895 "Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism" XP_046747635.1 6 Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease" XP_046749506.1 6 MetaCyc: PWY-4981;MetaCyc: PWY-6344;KEGG: 00330+2.6.1.13;MetaCyc: PWY-6922;MetaCyc: PWY-3341;Reactome: R-HSA-8964539 "L-proline biosynthesis II (from arginine)";"L-ornithine degradation II (Stickland reaction)";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis";"L-proline biosynthesis III (from L-ornithine)";"Glutamate and glutamine metabolism" XP_046741608.1 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" XP_046736216.1 2 Reactome: R-HSA-72706;Reactome: R-HSA-72702 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition" XP_046742049.1 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" XP_046753406.1 19 Reactome: R-HSA-399719;Reactome: R-HSA-442982;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5673000;Reactome: R-HSA-438066;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-9649948;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-6802946;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-9022692;Reactome: R-HSA-6802955;Reactome: R-HSA-5673001;Reactome: R-HSA-936837 "Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"RAF activation";"Unblocking of NMDA receptors, glutamate binding and activation";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Signaling downstream of RAS mutants";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Signaling by moderate kinase activity BRAF mutants";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Regulation of MECP2 expression and activity";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"RAF/MAP kinase cascade";"Ion transport by P-type ATPases" XP_046734667.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046748185.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046749710.1 1 Reactome: R-HSA-8850843 "Phosphate bond hydrolysis by NTPDase proteins" XP_046734794.1 6 Reactome: R-HSA-3000171;Reactome: R-HSA-2022090;Reactome: R-HSA-8874081;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814;Reactome: R-HSA-8948216 "Non-integrin membrane-ECM interactions";"Assembly of collagen fibrils and other multimeric structures";"MET activates PTK2 signaling";"Collagen degradation";"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization" XP_046742446.1 3 MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174 "S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II" XP_046735652.1 8 MetaCyc: PWY-5049;KEGG: 00950+1.14.16.2;MetaCyc: PWY-3581;MetaCyc: PWY-5394;Reactome: R-HSA-209905;KEGG: 00790+1.14.16.2;MetaCyc: PWY-6133;KEGG: 00350+1.14.16.2 "Rosmarinic acid biosynthesis II";"Isoquinoline alkaloid biosynthesis";"(S)-reticuline biosynthesis I";"Betalamic acid biosynthesis";"Catecholamine biosynthesis";"Folate biosynthesis";"(S)-reticuline biosynthesis II";"Tyrosine metabolism" XP_046750933.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046735315.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046735721.1 7 KEGG: 00250+3.5.1.2;KEGG: 00471+3.5.1.2;Reactome: R-HSA-210500;Reactome: R-HSA-8964539;MetaCyc: PWY-5921;Reactome: R-HSA-5628897;KEGG: 00220+3.5.1.2 "Alanine, aspartate and glutamate metabolism";"D-Glutamine and D-glutamate metabolism";"Glutamate Neurotransmitter Release Cycle";"Glutamate and glutamine metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"TP53 Regulates Metabolic Genes";"Arginine biosynthesis" XP_046752606.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046751289.1 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" XP_046737412.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression" XP_046740180.1 3 Reactome: R-HSA-391160;KEGG: 04660+2.7.10.2;Reactome: R-HSA-4420097 "Signal regulatory protein family interactions";"T cell receptor signaling pathway";"VEGFA-VEGFR2 Pathway" XP_046739317.1 1 Reactome: R-HSA-72165 "mRNA Splicing - Minor Pathway" XP_046743689.1 19 Reactome: R-HSA-983231;Reactome: R-HSA-4420097;Reactome: R-HSA-5663220;Reactome: R-HSA-418885;Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-525793;Reactome: R-HSA-8950505;Reactome: R-HSA-182971;Reactome: R-HSA-194840;Reactome: R-HSA-8964616;Reactome: R-HSA-114604;Reactome: R-HSA-5687128;Reactome: R-HSA-5625970;Reactome: R-HSA-5663213;Reactome: R-HSA-5627123;Reactome: R-HSA-5626467;Reactome: R-HSA-428543;Reactome: R-HSA-389359 "Factors involved in megakaryocyte development and platelet production";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate Formins";"DCC mediated attractive signaling";"Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"Myogenesis";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"EGFR downregulation";"Rho GTPase cycle";"G beta:gamma signalling through CDC42";"GPVI-mediated activation cascade";"MAPK6/MAPK4 signaling";"RHO GTPases activate KTN1";"RHO GTPases Activate WASPs and WAVEs";"RHO GTPases activate PAKs";"RHO GTPases activate IQGAPs";"Inactivation of CDC42 and RAC1";"CD28 dependent Vav1 pathway" XP_046734504.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046736680.1 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" XP_046740615.1 1 Reactome: R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins" XP_046734914.1 4 Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" XP_046741166.1 4 Reactome: R-HSA-9020702;MetaCyc: PWY-7511;Reactome: R-HSA-975144;Reactome: R-HSA-937039 "Interleukin-1 signaling";"Protein ubiquitination";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"IRAK1 recruits IKK complex" XP_046738287.1 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" XP_046753666.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046740367.1 3 KEGG: 00130+1.17.4.4;Reactome: R-HSA-6806664;MetaCyc: PWY-7999 "Ubiquinone and other terpenoid-quinone biosynthesis";"Metabolism of vitamin K";"Vitamin K-epoxide cycle" XP_046750541.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046737653.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046736517.1 2 Reactome: R-HSA-983231;Reactome: R-HSA-5205685 "Factors involved in megakaryocyte development and platelet production";"Pink/Parkin Mediated Mitophagy" XP_046740564.1 2 Reactome: R-HSA-71336;KEGG: 00710+2.7.1.14 "Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms" XP_046749659.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046752261.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046750669.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046746271.1 5 Reactome: R-HSA-212300;Reactome: R-HSA-5334118;Reactome: R-HSA-4655427;KEGG: 00270+2.1.1.37;Reactome: R-HSA-427413 "PRC2 methylates histones and DNA";"DNA methylation";"SUMOylation of DNA methylation proteins";"Cysteine and methionine metabolism";"NoRC negatively regulates rRNA expression" XP_046744446.1 7 Reactome: R-HSA-165181;Reactome: R-HSA-1632852;Reactome: R-HSA-5674400;Reactome: R-HSA-5628897;Reactome: R-HSA-198323;Reactome: R-HSA-8854214;Reactome: R-HSA-380972 "Inhibition of TSC complex formation by PKB";"Macroautophagy";"Constitutive Signaling by AKT1 E17K in Cancer";"TP53 Regulates Metabolic Genes";"AKT phosphorylates targets in the cytosol";"TBC/RABGAPs";"Energy dependent regulation of mTOR by LKB1-AMPK" XP_046739320.1 5 Reactome: R-HSA-5685938;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-6783310;Reactome: R-HSA-5696395 "HDR through Single Strand Annealing (SSA)";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Fanconi Anemia Pathway";"Formation of Incision Complex in GG-NER" XP_046752179.1 2 Reactome: R-HSA-8950505;Reactome: R-HSA-1237112 "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Methionine salvage pathway" XP_046743649.1 3 MetaCyc: PWY-6369;Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21 "Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system" XP_046754134.1 2 Reactome: R-HSA-6814122;Reactome: R-HSA-418594 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events" XP_046753230.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046745355.1 2 Reactome: R-HSA-5576894;Reactome: R-HSA-1296072 "Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels" XP_046742061.1 2 Reactome: R-HSA-171319;Reactome: R-HSA-3214847 "Telomere Extension By Telomerase";"HATs acetylate histones" XP_046744076.1 17 MetaCyc: PWY-5744;KEGG: 00640+6.4.1.2;Reactome: R-HSA-2426168;MetaCyc: PWY-5789;Reactome: R-HSA-3371599;Reactome: R-HSA-200425;Reactome: R-HSA-163765;KEGG: 00061+6.4.1.2;Reactome: R-HSA-196780;MetaCyc: PWY-5743;MetaCyc: PWY-6679;MetaCyc: PWY-5966-1;MetaCyc: PWY-4381;KEGG: 00720+6.4.1.2;KEGG: 00254+6.4.1.2;KEGG: 00620+6.4.1.2;MetaCyc: PWY-6722 "Glyoxylate assimilation";"Propanoate metabolism";"Activation of gene expression by SREBF (SREBP)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Defective HLCS causes multiple carboxylase deficiency";"Carnitine metabolism";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis";"Biotin transport and metabolism";"3-hydroxypropanoate cycle";"Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Carbon fixation pathways in prokaryotes";"Aflatoxin biosynthesis";"Pyruvate metabolism";"Candicidin biosynthesis" XP_046748085.1 3 KEGG: 00970+6.1.1.19;Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" XP_046751981.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046748702.1 6 Reactome: R-HSA-196807;KEGG: 00760+6.3.5.1;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5653;MetaCyc: PWY-5381;MetaCyc: PWY-7761 "Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)" XP_046745759.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046739592.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046742288.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046753635.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" XP_046752283.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046743010.1 1 Reactome: R-HSA-5676934 "Protein repair" XP_046753004.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046753796.1 7 Reactome: R-HSA-2500257;Reactome: R-HSA-2470946;Reactome: R-HSA-9018519;Reactome: R-HSA-1221632;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-2468052 "Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin";"Estrogen-dependent gene expression";"Meiotic synapsis";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"Establishment of Sister Chromatid Cohesion" XP_046748372.1 9 Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5685938;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5693554 "G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Single Strand Annealing (SSA)";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" XP_046753431.1 5 KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7269 "Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)" XP_046735547.1 1 Reactome: R-HSA-419771 "Opsins" XP_046746244.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046735683.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046741021.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046750099.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046749012.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046746714.1 1 Reactome: R-HSA-525793 "Myogenesis" XP_046751477.1 30 Reactome: R-HSA-167158;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-167246;Reactome: R-HSA-2564830;Reactome: R-HSA-73772;Reactome: R-HSA-112382;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-73762;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-427413;Reactome: R-HSA-73779;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-5696400;Reactome: R-HSA-73863;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-167161;Reactome: R-HSA-6782210;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167152;Reactome: R-HSA-167160 "Formation of the HIV-1 Early Elongation Complex";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Tat-mediated elongation of the HIV-1 transcript";"Cytosolic iron-sulfur cluster assembly";"RNA Polymerase I Promoter Escape";"Formation of RNA Pol II elongation complex";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"Dual Incision in GG-NER";"RNA Polymerase I Transcription Termination";"Formation of the Early Elongation Complex";"mRNA Capping";"HIV Transcription Initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection" XP_046738506.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046737816.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046751259.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046749682.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046751432.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046744899.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046744545.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046739914.1 5 Reactome: R-HSA-1266695;Reactome: R-HSA-3214858;Reactome: R-HSA-201722;Reactome: R-HSA-8939243;Reactome: R-HSA-3247509 "Interleukin-7 signaling";"RMTs methylate histone arginines";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Chromatin modifying enzymes" XP_046750078.1 57 Reactome: R-HSA-75815;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-1236974;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-5607761;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-382556;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-450408;Reactome: R-HSA-4641257;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-8939902;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553 "Ubiquitin-dependent degradation of Cyclin D";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"ER-Phagosome pathway";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"ABC-family proteins mediated transport";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX2 expression and activity";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs" XP_046745953.1 2 Reactome: R-HSA-376176;Reactome: R-HSA-202433 "Signaling by ROBO receptors";"Generation of second messenger molecules" XP_046751782.1 2 Reactome: R-HSA-4755609;Reactome: R-HSA-446199 "Defective DHDDS causes retinitis pigmentosa 59";"Synthesis of Dolichyl-phosphate" XP_046739737.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046734428.1 2 Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13 "RHO GTPases activate PKNs";"Phosphatidylinositol signaling system" XP_046734666.1 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" XP_046734385.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046739540.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046745376.1 11 Reactome: R-HSA-3214858;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-6804114;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-1368108;Reactome: R-HSA-400206;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168 "RMTs methylate histone arginines";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Regulation of lipid metabolism by PPARalpha";"Estrogen-dependent gene expression";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)" XP_046738281.1 8 Reactome: R-HSA-9619483;Reactome: R-HSA-6804756;Reactome: R-HSA-1445148;Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-2151209;Reactome: R-HSA-9613354 "Activation of AMPK downstream of NMDARs";"Regulation of TP53 Activity through Phosphorylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Lipophagy" XP_046747547.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046734308.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046736190.1 2 Reactome: R-HSA-6784531;Reactome: R-HSA-6791226 "tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046739567.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046740290.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046735057.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046734049.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046734791.1 57 Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-382556;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-450408;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-4641258;Reactome: R-HSA-180585;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684 "FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"ABC-family proteins mediated transport";"Degradation of AXIN";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Degradation of DVL";"Vif-mediated degradation of APOBEC3G";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state" XP_046735605.1 6 Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689 "Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits" XP_046746091.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046753049.1 52 Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-5250924;Reactome: R-HSA-167246;Reactome: R-HSA-5601884;Reactome: R-HSA-73772;Reactome: R-HSA-167162;Reactome: R-HSA-73776;Reactome: R-HSA-73780;Reactome: R-HSA-674695;Reactome: R-HSA-203927;Reactome: R-HSA-427413;Reactome: R-HSA-76061;Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-5578749;Reactome: R-HSA-77075;Reactome: R-HSA-5617472;Reactome: R-HSA-73863;Reactome: R-HSA-113418;Reactome: R-HSA-8851708;Reactome: R-HSA-72165;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-167287;Reactome: R-HSA-72163;Reactome: R-HSA-167238;Reactome: R-HSA-73980;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-112382;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-75953;Reactome: R-HSA-73762;Reactome: R-HSA-6796648;Reactome: R-HSA-76066;Reactome: R-HSA-9018519;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-72203;Reactome: R-HSA-6782210;Reactome: R-HSA-75955;Reactome: R-HSA-167242;Reactome: R-HSA-167200;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-76071 "RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"B-WICH complex positively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase I Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Promoter Escape";"RNA Polymerase III Chain Elongation";"RNA Polymerase II Pre-transcription Events";"MicroRNA (miRNA) biogenesis";"NoRC negatively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"Transcriptional regulation by small RNAs";"RNA Pol II CTD phosphorylation and interaction with CE";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase I Transcription Termination";"Formation of the Early Elongation Complex";"Signaling by FGFR2 IIIa TM";"mRNA Splicing - Minor Pathway";"mRNA Capping";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Termination";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of RNA Pol II elongation complex";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Estrogen-dependent gene expression";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"Processing of Capped Intron-Containing Pre-mRNA";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Transcription Elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" XP_046748989.1 3 Reactome: R-HSA-9609523;Reactome: R-HSA-1799339;Reactome: R-HSA-1236974 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"SRP-dependent cotranslational protein targeting to membrane";"ER-Phagosome pathway" XP_046752722.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046739384.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046735981.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046753350.1 10 MetaCyc: PWY-5030;MetaCyc: PWY-2201;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-1722;MetaCyc: PWY-6613;MetaCyc: PWY-7909;Reactome: R-HSA-196757;MetaCyc: PWY-5497 "L-histidine degradation III";"Folate transformations I";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"One carbon pool by folate";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"Metabolism of folate and pterines";"Purine nucleobases degradation II (anaerobic)" XP_046753355.1 19 Reactome: R-HSA-438066;Reactome: R-HSA-9649948;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-5673000;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5576892;Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-6802955;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-9022692;Reactome: R-HSA-6802946;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-9620244;Reactome: R-HSA-111932 "Unblocking of NMDA receptors, glutamate binding and activation";"Signaling downstream of RAS mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"RAF activation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"Phase 0 - rapid depolarisation";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Regulation of MECP2 expression and activity";"Signaling by moderate kinase activity BRAF mutants";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB" XP_046747849.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046748691.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046740746.1 8 KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;Reactome: R-HSA-5173105;MetaCyc: PWY-7922;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;Reactome: R-HSA-5083629 "Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2" XP_046740756.1 3 Reactome: R-HSA-8868766;Reactome: R-HSA-6784531;Reactome: R-HSA-6785470 "rRNA processing in the mitochondrion";"tRNA processing in the nucleus";"tRNA processing in the mitochondrion" XP_046744110.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046752247.1 12 MetaCyc: PWY-5873;MetaCyc: PWY-6708;MetaCyc: PWY-7230;MetaCyc: PWY-5870;KEGG: 00130+1.14.99.60;MetaCyc: PWY-5856;MetaCyc: PWY-5855;Reactome: R-HSA-2142789;MetaCyc: PWY-7233;MetaCyc: PWY-5857;MetaCyc: PWY-5871;MetaCyc: PWY-5872 "Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)" XP_046746584.1 3 Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261 "Triglyceride biosynthesis";"Glycerolipid metabolism";"Glycerol degradation I" XP_046740985.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046741838.1 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046740715.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046752135.1 6 Reactome: R-HSA-5632968;Reactome: R-HSA-5632928;Reactome: R-HSA-5358606;Reactome: R-HSA-5632927;Reactome: R-HSA-6796648;Reactome: R-HSA-5358565 "Defective Mismatch Repair Associated With MSH6";"Defective Mismatch Repair Associated With MSH2";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With MSH3";"TP53 Regulates Transcription of DNA Repair Genes";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)" XP_046745824.1 2 MetaCyc: PWY-6981;KEGG: 00520+2.4.1.16 "Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism" XP_046740004.1 5 MetaCyc: PWY-6124;MetaCyc: PWY-6123;MetaCyc: PWY-7234;Reactome: R-HSA-73817;KEGG: 00230+6.3.2.6 "Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism" XP_046747750.1 14 MetaCyc: PWY-6598;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7725;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-8041 "Sciadonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis" XP_046745886.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046747181.1 5 Reactome: R-HSA-211981;Reactome: R-HSA-211945;Reactome: R-HSA-8937144;Reactome: R-HSA-1989781;Reactome: R-HSA-211976 "Xenobiotics";"Phase I - Functionalization of compounds";"Aryl hydrocarbon receptor signalling";"PPARA activates gene expression";"Endogenous sterols" XP_046743932.1 12 KEGG: 00500+2.7.7.9;MetaCyc: PWY-7343;MetaCyc: PWY-7817;KEGG: 00561+2.7.7.9;MetaCyc: PWY-3801;KEGG: 00520+2.7.7.9;Reactome: R-HSA-173599;Reactome: R-HSA-3322077;MetaCyc: PWY-6527;KEGG: 00052+2.7.7.9;MetaCyc: PWY-7238;KEGG: 00040+2.7.7.9 "Starch and sucrose metabolism";"UDP-alpha-D-glucose biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Sucrose degradation II (sucrose synthase)";"Amino sugar and nucleotide sugar metabolism";"Formation of the active cofactor, UDP-glucuronate";"Glycogen synthesis";"Stachyose degradation";"Galactose metabolism";"Sucrose biosynthesis II";"Pentose and glucuronate interconversions" XP_046743749.1 4 Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination" XP_046750408.1 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" XP_046746303.1 5 Reactome: R-HSA-1660662;Reactome: R-HSA-4341670;Reactome: R-HSA-2132295;Reactome: R-HSA-4085001;Reactome: R-HSA-6798695 "Glycosphingolipid metabolism";"Defective NEU1 causes sialidosis";"MHC class II antigen presentation";"Sialic acid metabolism";"Neutrophil degranulation" XP_046752885.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046736901.1 9 Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-6798695;Reactome: R-HSA-5674135;Reactome: R-HSA-8943724 "Macroautophagy";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"mTOR signalling";"Neutrophil degranulation";"MAP2K and MAPK activation";"Regulation of PTEN gene transcription" XP_046735004.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046749470.1 56 Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-983168;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-75815;Reactome: R-HSA-5358346;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-1236974;Reactome: R-HSA-5689880;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-9010553;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-450408;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog ligand biogenesis";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"ER-Phagosome pathway";"Ub-specific processing proteases";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of expression of SLITs and ROBOs";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Neddylation";"Degradation of AXIN" XP_046741477.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046743520.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046743069.1 4 Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"MHC class II antigen presentation";"RHO GTPases activate KTN1" XP_046739866.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046735263.1 13 Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226 "Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046751924.1 4 MetaCyc: PWY-6823;Reactome: R-HSA-947581;KEGG: 00790+4.1.99.22;KEGG: 00790+4.6.1.17 "Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Folate biosynthesis" XP_046750774.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046753673.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046737574.1 2 Reactome: R-HSA-1660662;Reactome: R-HSA-390471 "Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis" XP_046736356.1 2 KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7 "Aminobenzoate degradation";"Pyruvate metabolism" XP_046735879.1 2 Reactome: R-HSA-5218920;Reactome: R-HSA-418990 "VEGFR2 mediated vascular permeability";"Adherens junctions interactions" XP_046737266.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046739297.1 7 Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046743750.1 4 Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236 "mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046742286.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046734382.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046741466.1 3 Reactome: R-HSA-71336;KEGG: 00480+1.1.1.44;KEGG: 00030+1.1.1.44 "Pentose phosphate pathway";"Glutathione metabolism";"Pentose phosphate pathway" XP_046745657.1 1 Reactome: R-HSA-191859 "snRNP Assembly" XP_046749201.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046745942.1 2 Reactome: R-HSA-2682334;Reactome: R-HSA-3928665 "EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells" XP_046737960.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046739513.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046734395.1 1 Reactome: R-HSA-9616222 "Transcriptional regulation of granulopoiesis" XP_046748439.1 14 MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-7035 "Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis" XP_046738965.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046737190.1 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" XP_046749139.1 4 KEGG: 00860+1.14.14.18;Reactome: R-HSA-917937;MetaCyc: PWY-5874;Reactome: R-HSA-189483 "Porphyrin and chlorophyll metabolism";"Iron uptake and transport";"Heme degradation I";"Heme degradation" XP_046736011.1 5 KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;MetaCyc: PWY-5084 "Lysine degradation";"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA" XP_046738736.1 4 KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174;Reactome: R-HSA-1237112;MetaCyc: PWY-4361 "Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I" XP_046749447.1 3 Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-6807878 "Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"COPI-mediated anterograde transport" XP_046748505.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046740449.1 2 Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13 "Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system" XP_046745277.1 5 Reactome: R-HSA-168164;Reactome: R-HSA-937072;Reactome: R-HSA-166166;Reactome: R-HSA-937041;Reactome: R-HSA-936964 "Toll Like Receptor 3 (TLR3) Cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"MyD88-independent TLR4 cascade";"IKK complex recruitment mediated by RIP1";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon" XP_046742078.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046753338.1 19 Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-9649948;Reactome: R-HSA-438066;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5576892;Reactome: R-HSA-5673000;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-5673001;Reactome: R-HSA-936837;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692 "Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Signaling downstream of RAS mutants";"Unblocking of NMDA receptors, glutamate binding and activation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"Phase 0 - rapid depolarisation";"RAF activation";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"RAF/MAP kinase cascade";"Ion transport by P-type ATPases";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity" XP_046740790.1 2 KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1 "Pentose phosphate pathway";"Purine metabolism" XP_046744303.1 12 Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-9609690 "EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"HCMV Early Events" XP_046739217.1 1 Reactome: R-HSA-5601884 "PIWI-interacting RNA (piRNA) biogenesis" XP_046737721.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046750897.1 3 Reactome: R-HSA-1358803;MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Downregulation of ERBB2:ERBB3 signaling";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046734453.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046746718.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046747143.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046746207.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046737573.1 2 Reactome: R-HSA-1660662;Reactome: R-HSA-390471 "Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis" XP_046743830.1 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" XP_046752704.1 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" XP_046752886.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046744437.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046751506.1 4 Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation" XP_046748763.1 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" XP_046744276.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046745613.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046739437.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046753629.1 1 Reactome: R-HSA-186797 "Signaling by PDGF" XP_046743291.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046747641.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046737017.1 5 KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;MetaCyc: PWY-5084 "Lysine degradation";"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA" XP_046740446.1 22 Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-5358752;Reactome: R-HSA-5358747;Reactome: R-HSA-9648025;Reactome: R-HSA-5673000;Reactome: R-HSA-5467337;Reactome: R-HSA-2467813;Reactome: R-HSA-5675221;Reactome: R-HSA-5339716;Reactome: R-HSA-2500257;Reactome: R-HSA-4641262;Reactome: R-HSA-5467348;Reactome: R-HSA-432142;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-5358749;Reactome: R-HSA-6811558;Reactome: R-HSA-196299;Reactome: R-HSA-195253;Reactome: R-HSA-5358751;Reactome: R-HSA-5467340 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"T41 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"RAF activation";"APC truncation mutants have impaired AXIN binding";"Separation of Sister Chromatids";"Negative regulation of MAPK pathway";"Misspliced GSK3beta mutants stabilize beta-catenin";"Resolution of Sister Chromatid Cohesion";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Truncations of AMER1 destabilize the destruction complex";"Platelet sensitization by LDL";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"S37 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Beta-catenin phosphorylation cascade";"Degradation of beta-catenin by the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex" XP_046736493.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046745927.1 13 Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-975957 "SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046743949.1 4 KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"DARPP-32 events";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" XP_046749744.1 9 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-198323;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"AKT phosphorylates targets in the cytosol";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046748880.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046751138.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-8964038 "Neutrophil degranulation";"LDL clearance" XP_046751623.1 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" XP_046750385.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046736530.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046753602.1 4 KEGG: 00910+1.4.1.14;Reactome: R-HSA-73621;KEGG: 00250+1.4.1.14;MetaCyc: PWY-6963 "Nitrogen metabolism";"Pyrimidine catabolism";"Alanine, aspartate and glutamate metabolism";"Ammonia assimilation cycle I" XP_046745669.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046737257.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046743920.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046750853.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" XP_046745417.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046748470.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046735755.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046739395.1 4 MetaCyc: PWY-5737;MetaCyc: PWY-6922;Reactome: R-HSA-70688;KEGG: 00330+1.5.5.2 "(5R)-carbapenem carboxylate biosynthesis";"L-Ndelta-acetylornithine biosynthesis";"Proline catabolism";"Arginine and proline metabolism" XP_046736445.1 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046736200.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046744774.1 8 Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-3371571;Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-8943724 "Macroautophagy";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"HSF1-dependent transactivation";"Amino acids regulate mTORC1";"mTOR signalling";"Regulation of PTEN gene transcription" XP_046736516.1 2 Reactome: R-HSA-5205685;Reactome: R-HSA-983231 "Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production" XP_046740045.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046749860.1 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" XP_046735278.1 1 KEGG: 00970+6.1.1.9 "Aminoacyl-tRNA biosynthesis" XP_046738896.1 14 Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-1632852;Reactome: R-HSA-6807878;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-5620924;Reactome: R-HSA-6811436 "Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Macroautophagy";"COPI-mediated anterograde transport";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"Intraflagellar transport";"COPI-independent Golgi-to-ER retrograde traffic" XP_046744676.1 13 Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-6791226 "Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046746198.1 3 Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-6798695 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Neutrophil degranulation" XP_046749455.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex" XP_046736460.1 25 Reactome: R-HSA-8939236;Reactome: R-HSA-9616222;Reactome: R-HSA-8941333;Reactome: R-HSA-8939247;Reactome: R-HSA-8940973;Reactome: R-HSA-8939245;Reactome: R-HSA-8939246;Reactome: R-HSA-8949275;Reactome: R-HSA-8936459;Reactome: R-HSA-8939256;Reactome: R-HSA-8877330;Reactome: R-HSA-8951936;Reactome: R-HSA-8941284;Reactome: R-HSA-8941858;Reactome: R-HSA-8941326;Reactome: R-HSA-8935964;Reactome: R-HSA-9018519;Reactome: R-HSA-8941332;Reactome: R-HSA-8951911;Reactome: R-HSA-8878166;Reactome: R-HSA-8939243;Reactome: R-HSA-8939902;Reactome: R-HSA-8931987;Reactome: R-HSA-8939242;Reactome: R-HSA-8934593 "RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation of granulopoiesis";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX1 regulates transcription of genes involved in WNT signaling";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX3 regulates p14-ARF";"RUNX2 regulates chondrocyte maturation";"Regulation of RUNX3 expression and activity";"RUNX2 regulates bone development";"RUNX1 regulates expression of components of tight junctions";"Estrogen-dependent gene expression";"RUNX2 regulates genes involved in cell migration";"RUNX3 regulates RUNX1-mediated transcription";"Transcriptional regulation by RUNX2";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Regulation of RUNX2 expression and activity";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"Regulation of RUNX1 Expression and Activity" XP_046741066.1 9 MetaCyc: PWY-5743;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7117;Reactome: R-HSA-1475029;MetaCyc: PWY-7115;MetaCyc: PWY-5789;MetaCyc: PWY-241;MetaCyc: PWY-6142;MetaCyc: PWY-5744 "3-hydroxypropanoate cycle";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glyoxylate assimilation" XP_046737242.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046736510.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046743037.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046742492.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046733993.1 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" XP_046734227.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046750130.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046751366.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046751340.1 2 KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10 "One carbon pool by folate";"Glycine, serine and threonine metabolism" XP_046752703.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046749431.1 5 Reactome: R-HSA-5610780;Reactome: R-HSA-5610787;Reactome: R-HSA-5632684;Reactome: R-HSA-5610783;Reactome: R-HSA-5610785 "Degradation of GLI1 by the proteasome";"Hedgehog 'off' state";"Hedgehog 'on' state";"Degradation of GLI2 by the proteasome";"GLI3 is processed to GLI3R by the proteasome" XP_046739913.1 1 Reactome: R-HSA-191859 "snRNP Assembly" XP_046734039.1 4 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.10;Reactome: R-HSA-2408522;KEGG: 00450+6.1.1.10 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Selenocompound metabolism" XP_046741028.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046737651.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046741646.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046748564.1 2 Reactome: R-HSA-1839117;Reactome: R-HSA-5655302 "Signaling by cytosolic FGFR1 fusion mutants";"Signaling by FGFR1 in disease" XP_046739711.1 3 KEGG: 00240+3.6.1.17;Reactome: R-HSA-3299685;KEGG: 00230+3.6.1.17 "Pyrimidine metabolism";"Detoxification of Reactive Oxygen Species";"Purine metabolism" XP_046752401.1 7 Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518 "Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2" XP_046748979.1 3 MetaCyc: PWY-7831;Reactome: R-HSA-9033807;MetaCyc: PWY-7833 "ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide";"ABO blood group biosynthesis";"Biosynthesis of Lewis epitopes (H. pylori)" XP_046738461.1 1 Reactome: R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins" XP_046751778.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046750986.1 8 Reactome: R-HSA-5693554;Reactome: R-HSA-912446;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-8953750;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Meiotic recombination";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Transcriptional Regulation by E2F6";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)" XP_046742748.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046746650.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection" XP_046752731.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046744643.1 2 Reactome: R-HSA-389661;Reactome: R-HSA-9033241 "Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import" XP_046747952.1 2 Reactome: R-HSA-3928665;Reactome: R-HSA-2682334 "EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling" XP_046742157.1 14 MetaCyc: PWY-6598;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041 "Sciadonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis" XP_046753235.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046752215.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046751588.1 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" XP_046734495.1 12 KEGG: 04150+2.7.11.1;Reactome: R-HSA-416482;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-194840;Reactome: R-HSA-416476;Reactome: R-HSA-193648;Reactome: R-HSA-418885 "mTOR signaling pathway";"G alpha (12/13) signalling events";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"Rho GTPase cycle";"G alpha (q) signalling events";"NRAGE signals death through JNK";"DCC mediated attractive signaling" XP_046745749.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046747722.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046735751.1 2 KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085 "Starch and sucrose metabolism";"Digestion of dietary carbohydrate" XP_046743941.1 4 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"DARPP-32 events";"Th1 and Th2 cell differentiation" XP_046741161.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046737897.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046747843.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046743009.1 1 Reactome: R-HSA-5676934 "Protein repair" XP_046744394.1 12 Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" XP_046741331.1 10 Reactome: R-HSA-9615017;Reactome: R-HSA-400206;Reactome: R-HSA-9022692;Reactome: R-HSA-427413;Reactome: R-HSA-983231;Reactome: R-HSA-8936459;Reactome: R-HSA-9022702;Reactome: R-HSA-9022538;Reactome: R-HSA-3899300;Reactome: R-HSA-9022699 "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha";"Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"MECP2 regulates transcription of neuronal ligands";"Loss of MECP2 binding ability to 5mC-DNA";"SUMOylation of transcription cofactors";"MECP2 regulates neuronal receptors and channels" XP_046735611.1 2 Reactome: R-HSA-2029482;Reactome: R-HSA-5663213 "Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs" XP_046751029.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046735193.1 3 Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" XP_046746376.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046734517.1 3 Reactome: R-HSA-6804760;Reactome: R-HSA-191859;Reactome: R-HSA-3214858 "Regulation of TP53 Activity through Methylation";"snRNP Assembly";"RMTs methylate histone arginines" XP_046749571.1 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" XP_046741046.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046739057.1 5 Reactome: R-HSA-174490;Reactome: R-HSA-162588;Reactome: R-HSA-917729;Reactome: R-HSA-9615710;Reactome: R-HSA-9610379 "Membrane binding and targetting of GAG proteins";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy";"HCMV Late Events" XP_046742671.1 3 KEGG: 00564+4.1.1.65;MetaCyc: PWY-5669;Reactome: R-HSA-1483213 "Glycerophospholipid metabolism";"Phosphatidylserine and phosphatidylethanolamine biosynthesis I";"Synthesis of PE" XP_046741948.1 12 MetaCyc: PWY-5871;MetaCyc: PWY-5872;MetaCyc: PWY-5857;KEGG: 00130+2.1.1.222+2.1.1.64;MetaCyc: PWY-7233;Reactome: R-HSA-2142789;MetaCyc: PWY-5856;MetaCyc: PWY-5855;MetaCyc: PWY-5870;MetaCyc: PWY-6708;MetaCyc: PWY-7230;MetaCyc: PWY-5873 "Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-7 biosynthesis (eukaryotic)" XP_046735035.1 1 Reactome: R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" XP_046734704.1 1 Reactome: R-HSA-977347 "Serine biosynthesis" XP_046738140.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046753027.1 4 KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193 "Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I" XP_046743431.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046736585.1 5 MetaCyc: PWY-6168;KEGG: 00740+2.7.1.26;Reactome: R-HSA-196843;MetaCyc: PWY-7863;MetaCyc: PWY-5523 "Flavin biosynthesis III (fungi)";"Riboflavin metabolism";"Vitamin B2 (riboflavin) metabolism";"Roseoflavin biosynthesis";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)" XP_046745767.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046753592.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046748909.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046741627.1 2 MetaCyc: PWY-6019;KEGG: 00240+4.2.1.70 "Pseudouridine degradation";"Pyrimidine metabolism" XP_046748974.1 3 Reactome: R-HSA-196783;MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33 "Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis" XP_046742983.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046746051.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046738824.1 3 MetaCyc: PWY-5987;MetaCyc: PWY-5996;Reactome: R-HSA-75105 "Sorgoleone biosynthesis";"Oleate biosynthesis II (animals and fungi)";"Fatty acyl-CoA biosynthesis" XP_046747335.1 7 Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes" XP_046737087.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046752835.1 3 Reactome: R-HSA-196757;KEGG: 00790+6.3.2.17;MetaCyc: PWY-2161 "Metabolism of folate and pterines";"Folate biosynthesis";"Folate polyglutamylation" XP_046752214.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046752343.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046745963.1 3 KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046733824.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046742046.1 6 Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733 "Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis" XP_046744984.1 1 KEGG: 00450+1.8.1.9 "Selenocompound metabolism" XP_046752429.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046740116.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046737194.1 4 Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-3000178;Reactome: R-HSA-8874081 "Non-integrin membrane-ECM interactions";"Laminin interactions";"ECM proteoglycans";"MET activates PTK2 signaling" XP_046739133.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046747549.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046748291.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046737868.1 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" XP_046737304.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046743717.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046743476.1 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" XP_046739826.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046754132.1 6 Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-176187 "Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress" XP_046738967.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046748484.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046746895.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046736175.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046737462.1 6 KEGG: 00290+4.2.1.33;KEGG: 00020+4.2.1.3;Reactome: R-HSA-1268020;Reactome: R-HSA-71403;KEGG: 00630+4.2.1.3;KEGG: 00720+4.2.1.3 "Valine, leucine and isoleucine biosynthesis";"Citrate cycle (TCA cycle)";"Mitochondrial protein import";"Citric acid cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes" XP_046734398.1 1 Reactome: R-HSA-9616222 "Transcriptional regulation of granulopoiesis" XP_046744822.1 5 Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-73762;Reactome: R-HSA-8943724;Reactome: R-HSA-6804758 "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"RNA Polymerase I Transcription Initiation";"Regulation of PTEN gene transcription";"Regulation of TP53 Activity through Acetylation" XP_046739699.1 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" XP_046740889.1 1 Reactome: R-HSA-437239 "Recycling pathway of L1" XP_046745714.1 2 MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1 "S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism" XP_046736108.1 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" XP_046739639.1 3 Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-8963901 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Chylomicron remodeling" XP_046737569.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046747595.1 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" XP_046749558.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046743234.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046738001.1 5 KEGG: 00010+4.1.1.32;KEGG: 00620+4.1.1.32;KEGG: 00020+4.1.1.32;Reactome: R-HSA-70263;MetaCyc: PWY-7383 "Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)" XP_046735554.1 1 Reactome: R-HSA-419771 "Opsins" XP_046745413.1 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" XP_046743660.1 5 Reactome: R-HSA-380994;Reactome: R-HSA-9633012;KEGG: 00250+6.3.5.4;Reactome: R-HSA-9648895;Reactome: R-HSA-8963693 "ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Alanine, aspartate and glutamate metabolism";"Response of EIF2AK1 (HRI) to heme deficiency";"Aspartate and asparagine metabolism" XP_046738830.1 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" XP_046745999.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046737948.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046752714.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046744157.1 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" XP_046753937.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046739720.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-8963901 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Chylomicron remodeling" XP_046752466.1 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" XP_046741953.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046741022.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046752981.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046754008.1 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" XP_046738877.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046737645.1 2 Reactome: R-HSA-381038;Reactome: R-HSA-1799339 "XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane" XP_046753784.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046744319.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046746321.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046745242.1 2 Reactome: R-HSA-5696394;Reactome: R-HSA-5689603 "DNA Damage Recognition in GG-NER";"UCH proteinases" XP_046738562.1 2 Reactome: R-HSA-6796648;Reactome: R-HSA-6783310 "TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway" XP_046751062.1 3 Reactome: R-HSA-164843;Reactome: R-HSA-5693571;Reactome: R-HSA-3108214 "2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)";"SUMOylation of DNA damage response and repair proteins" XP_046741115.1 1 Reactome: R-HSA-606279 "Deposition of new CENPA-containing nucleosomes at the centromere" XP_046744109.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046734384.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046742044.1 6 MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463 "Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis" XP_046748802.1 3 Reactome: R-HSA-392154;Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2 "Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction";"Purine metabolism" XP_046737641.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046742681.1 7 Reactome: R-HSA-416476;Reactome: R-HSA-140837;Reactome: R-HSA-8957275;Reactome: R-HSA-418594;Reactome: R-HSA-381426;Reactome: R-HSA-375276;Reactome: R-HSA-114608 "G alpha (q) signalling events";"Intrinsic Pathway of Fibrin Clot Formation";"Post-translational protein phosphorylation";"G alpha (i) signalling events";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Peptide ligand-binding receptors";"Platelet degranulation" XP_046734737.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046737675.1 2 Reactome: R-HSA-5357956;Reactome: R-HSA-5357905 "TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling" XP_046734758.1 1 Reactome: R-HSA-2173788 "Downregulation of TGF-beta receptor signaling" XP_046734233.1 2 MetaCyc: PWY-5386;KEGG: 00620+3.1.2.6 "Methylglyoxal degradation I";"Pyruvate metabolism" XP_046751574.1 3 Reactome: R-HSA-381426;Reactome: R-HSA-5362798;Reactome: R-HSA-8957275 "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Release of Hh-Np from the secreting cell";"Post-translational protein phosphorylation" XP_046737646.1 32 Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-112382;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-9018519;Reactome: R-HSA-75953;Reactome: R-HSA-6796648;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-75955;Reactome: R-HSA-167162;Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-73779;Reactome: R-HSA-77075;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-8851708;Reactome: R-HSA-113418;Reactome: R-HSA-72165;Reactome: R-HSA-72163;Reactome: R-HSA-167238;Reactome: R-HSA-167161;Reactome: R-HSA-167287;Reactome: R-HSA-168325;Reactome: R-HSA-72086 "Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Formation of RNA Pol II elongation complex";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Signaling by FGFR2 IIIa TM";"Formation of the Early Elongation Complex";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway";"Pausing and recovery of Tat-mediated HIV elongation";"HIV Transcription Initiation";"HIV elongation arrest and recovery";"Viral Messenger RNA Synthesis";"mRNA Capping" XP_046736852.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046750479.1 6 Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695 "GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex" XP_046751820.1 1 Reactome: R-HSA-380320 "Recruitment of NuMA to mitotic centrosomes" XP_046742272.1 1 Reactome: R-HSA-428359 "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" XP_046746316.1 1 Reactome: R-HSA-176974 "Unwinding of DNA" XP_046748126.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046744839.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046742077.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046735153.1 19 Reactome: R-HSA-8963901;Reactome: R-HSA-3000480;Reactome: R-HSA-8964046;Reactome: R-HSA-8963888;Reactome: R-HSA-3000484;Reactome: R-HSA-8957275;Reactome: R-HSA-3000471;Reactome: R-HSA-5686938;Reactome: R-HSA-8964041;Reactome: R-HSA-8964026;Reactome: R-HSA-202733;Reactome: R-HSA-8964038;Reactome: R-HSA-975634;Reactome: R-HSA-8856828;Reactome: R-HSA-381426;Reactome: R-HSA-8856825;Reactome: R-HSA-8866423;Reactome: R-HSA-432142;Reactome: R-HSA-3000497 "Chylomicron remodeling";"Scavenging by Class A Receptors";"VLDL clearance";"Chylomicron assembly";"Scavenging by Class F Receptors";"Post-translational protein phosphorylation";"Scavenging by Class B Receptors";"Regulation of TLR by endogenous ligand";"LDL remodeling";"Chylomicron clearance";"Cell surface interactions at the vascular wall";"LDL clearance";"Retinoid metabolism and transport";"Clathrin-mediated endocytosis";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Cargo recognition for clathrin-mediated endocytosis";"VLDL assembly";"Platelet sensitization by LDL";"Scavenging by Class H Receptors" XP_046738084.1 16 Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-72689 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits" XP_046740990.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046739298.1 7 Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046751038.1 5 Reactome: R-HSA-5668599;Reactome: R-HSA-1169408;Reactome: R-HSA-6804756;Reactome: R-HSA-6811555;Reactome: R-HSA-936440 "RHO GTPases Activate NADPH Oxidases";"ISG15 antiviral mechanism";"Regulation of TP53 Activity through Phosphorylation";"PI5P Regulates TP53 Acetylation";"Negative regulators of DDX58/IFIH1 signaling" XP_046749961.1 9 MetaCyc: PWY-8086;MetaCyc: PWY-6142;KEGG: 00620+6.4.1.1;KEGG: 00020+6.4.1.1;KEGG: 00720+6.4.1.1;Reactome: R-HSA-3371599;Reactome: R-HSA-70263;MetaCyc: PWY-6146;Reactome: R-HSA-196780 "(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Defective HLCS causes multiple carboxylase deficiency";"Gluconeogenesis";"Methanobacterium thermoautotrophicum biosynthetic metabolism";"Biotin transport and metabolism" XP_046753445.1 16 Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702 "Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition" XP_046748294.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046752055.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046745750.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046738972.1 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" XP_046738421.1 18 MetaCyc: PWY-8053;Reactome: R-HSA-1482839;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482801;MetaCyc: PWY-8051;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482925;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-7416;KEGG: 00592+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7783;Reactome: R-HSA-1482922 "Anandamide biosynthesis II";"Acyl chain remodelling of PE";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PS";"Anandamide biosynthesis I";"Linoleic acid metabolism";"Acyl chain remodelling of PG";"Arachidonic acid metabolism";"Acyl chain remodelling of PC";"Phospholipid remodeling (phosphatidylcholine, yeast)";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Plasmalogen degradation";"Acyl chain remodelling of PI" XP_046749902.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046740281.1 5 Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange" XP_046751387.1 3 Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation" XP_046733825.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046738728.1 6 Reactome: R-HSA-112382;Reactome: R-HSA-5632684;Reactome: R-HSA-8866654;Reactome: R-HSA-201722;Reactome: R-HSA-75955;Reactome: R-HSA-674695 "Formation of RNA Pol II elongation complex";"Hedgehog 'on' state";"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of the beta-catenin:TCF transactivating complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events" XP_046741933.1 5 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-3214815 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"HDACs deacetylate histones" XP_046739151.1 5 Reactome: R-HSA-9033241;Reactome: R-HSA-75896;Reactome: R-HSA-9033500;KEGG: 00565+2.5.1.26;MetaCyc: PWY-7782 "Peroxisomal protein import";"Plasmalogen biosynthesis";"TYSND1 cleaves peroxisomal proteins";"Ether lipid metabolism";"Plasmalogen biosynthesis" XP_046740096.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046747708.1 3 Reactome: R-HSA-6807004;Reactome: R-HSA-202427;Reactome: R-HSA-6798695 "Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation" XP_046745495.1 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" XP_046746531.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046734622.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046736062.1 3 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046742719.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046741332.1 10 Reactome: R-HSA-9022692;Reactome: R-HSA-427413;Reactome: R-HSA-983231;Reactome: R-HSA-9615017;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-9022538;Reactome: R-HSA-3899300;Reactome: R-HSA-9022699;Reactome: R-HSA-8936459 "Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"Loss of MECP2 binding ability to 5mC-DNA";"SUMOylation of transcription cofactors";"MECP2 regulates neuronal receptors and channels";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046747839.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046752296.1 13 Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-9633012 "L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046740101.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046747536.1 3 Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-5578775 "Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Ion homeostasis" XP_046747631.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-5357905 "RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling" XP_046734738.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046737823.1 5 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-6784531;Reactome: R-HSA-72163 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"tRNA processing in the nucleus";"mRNA Splicing - Major Pathway" XP_046741407.1 5 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878;Reactome: R-HSA-204005;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"COPII-mediated vesicle transport";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network" XP_046745460.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046753980.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046753972.1 9 Reactome: R-HSA-1989781;Reactome: R-HSA-5617472;Reactome: R-HSA-400206;Reactome: R-HSA-2426168;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082 "PPARA activates gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of lipid metabolism by PPARalpha";"Activation of gene expression by SREBF (SREBP)";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression" XP_046752524.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046737800.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046753728.1 1 Reactome: R-HSA-912446 "Meiotic recombination" XP_046735941.1 1 Reactome: R-HSA-1483166 "Synthesis of PA" XP_046734625.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" XP_046735326.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046753705.1 4 Reactome: R-HSA-73817;KEGG: 00230+6.3.5.2;MetaCyc: PWY-7221;KEGG: 00983+6.3.5.2 "Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes" XP_046746807.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046748310.1 7 Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-156711 "Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G0 and Early G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"Polo-like kinase mediated events" XP_046736041.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046734312.1 16 Reactome: R-HSA-4086398;Reactome: R-HSA-5687128;Reactome: R-HSA-2559585;Reactome: R-HSA-426496;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-8986944;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-8948700;Reactome: R-HSA-2559580;Reactome: R-HSA-8934593;Reactome: R-HSA-9029569 "Ca2+ pathway";"MAPK6/MAPK4 signaling";"Oncogene Induced Senescence";"Post-transcriptional silencing by small RNAs";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by MECP2";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oxidative Stress Induced Senescence";"Regulation of RUNX1 Expression and Activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" XP_046749805.1 39 Reactome: R-HSA-2033519;Reactome: R-HSA-5655253;Reactome: R-HSA-5654219;Reactome: R-HSA-1839122;Reactome: R-HSA-5654726;Reactome: R-HSA-1839130;Reactome: R-HSA-109704;Reactome: R-HSA-5654720;Reactome: R-HSA-2219530;Reactome: R-HSA-5654688;Reactome: R-HSA-190322;Reactome: R-HSA-5654727;Reactome: R-HSA-5655302;Reactome: R-HSA-8853338;Reactome: R-HSA-190372;Reactome: R-HSA-5654693;Reactome: R-HSA-190373;Reactome: R-HSA-5654719;Reactome: R-HSA-5654732;Reactome: R-HSA-5658623;Reactome: R-HSA-5654700;Reactome: R-HSA-1257604;Reactome: R-HSA-5654689;Reactome: R-HSA-190371;Reactome: R-HSA-5654699;Reactome: R-HSA-5654228;Reactome: R-HSA-5654712;Reactome: R-HSA-5654221;Reactome: R-HSA-2033514;Reactome: R-HSA-5654687;Reactome: R-HSA-5654704;Reactome: R-HSA-5654227;Reactome: R-HSA-5654706;Reactome: R-HSA-6811558;Reactome: R-HSA-5673001;Reactome: R-HSA-5654695;Reactome: R-HSA-5654710;Reactome: R-HSA-5654733;Reactome: R-HSA-190375 "Activated point mutants of FGFR2";"Signaling by FGFR2 in disease";"Phospholipase C-mediated cascade: FGFR1";"Signaling by activated point mutants of FGFR1";"Negative regulation of FGFR1 signaling";"Signaling by activated point mutants of FGFR3";"PI3K Cascade";"PI-3K cascade:FGFR4";"Constitutive Signaling by Aberrant PI3K in Cancer";"SHC-mediated cascade:FGFR1";"FGFR4 ligand binding and activation";"Negative regulation of FGFR2 signaling";"Signaling by FGFR1 in disease";"Signaling by FGFR3 point mutants in cancer";"FGFR3c ligand binding and activation";"FRS-mediated FGFR1 signaling";"FGFR1c ligand binding and activation";"SHC-mediated cascade:FGFR4";"Negative regulation of FGFR3 signaling";"FGFRL1 modulation of FGFR1 signaling";"FRS-mediated FGFR2 signaling";"PIP3 activates AKT signaling";"PI-3K cascade:FGFR1";"FGFR3b ligand binding and activation";"SHC-mediated cascade:FGFR2";"Phospholipase C-mediated cascade, FGFR4";"FRS-mediated FGFR4 signaling";"Phospholipase C-mediated cascade, FGFR2";"FGFR3 mutant receptor activation";"Downstream signaling of activated FGFR1";"SHC-mediated cascade:FGFR3";"Phospholipase C-mediated cascade, FGFR3";"FRS-mediated FGFR3 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RAF/MAP kinase cascade";"PI-3K cascade:FGFR2";"PI-3K cascade:FGFR3";"Negative regulation of FGFR4 signaling";"FGFR2c ligand binding and activation" XP_046746068.1 16 KEGG: 00020+6.2.1.4;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-5913;MetaCyc: PWY-5749;KEGG: 00720+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00640+6.2.1.4;MetaCyc: PWY-6969;MetaCyc: PWY-5537;KEGG: 00660+6.2.1.5;MetaCyc: PWY-7384;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5538;MetaCyc: PWY-5690 "Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"Itaconate degradation";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Reductive TCA cycle II";"Propanoate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate V";"C5-Branched dibasic acid metabolism";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Propanoate metabolism";"Pyruvate fermentation to acetate VI";"TCA cycle II (plants and fungi)" XP_046753924.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046736911.1 3 Reactome: R-HSA-72165;Reactome: R-HSA-191859;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"snRNP Assembly";"mRNA Splicing - Major Pathway" XP_046735103.1 3 Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.51;MetaCyc: PWY-6807 "Neutrophil degranulation";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)" XP_046749301.1 5 Reactome: R-HSA-6807004;Reactome: R-HSA-8875360;Reactome: R-HSA-8856825;Reactome: R-HSA-182971;Reactome: R-HSA-8856828 "Negative regulation of MET activity";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation";"Clathrin-mediated endocytosis" XP_046740477.1 12 KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7416;MetaCyc: PWY-8053 "Arachidonic acid metabolism";"Plasmalogen degradation";"Linoleic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II" XP_046735527.1 3 Reactome: R-HSA-4086400;Reactome: R-HSA-4608870;Reactome: R-HSA-373080 "PCP/CE pathway";"Asymmetric localization of PCP proteins";"Class B/2 (Secretin family receptors)" XP_046745331.1 2 Reactome: R-HSA-390648;Reactome: R-HSA-525793 "Muscarinic acetylcholine receptors";"Myogenesis" XP_046746216.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046737102.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046745414.1 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" XP_046739166.1 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" XP_046736896.1 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" XP_046739507.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046743240.1 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" XP_046752049.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046734265.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046741584.1 2 Reactome: R-HSA-204005;Reactome: R-HSA-5694530 "COPII-mediated vesicle transport";"Cargo concentration in the ER" XP_046752377.1 7 MetaCyc: PWY-6692;KEGG: 00190+7.1.1.2;MetaCyc: PWY-4302;Reactome: R-HSA-611105;Reactome: R-HSA-6799198;MetaCyc: PWY-5083;MetaCyc: PWY-3781 "Fe(II) oxidation";"Oxidative phosphorylation";"Aerobic respiration III (alternative oxidase pathway)";"Respiratory electron transport";"Complex I biogenesis";"NAD/NADH phosphorylation and dephosphorylation";"Aerobic respiration I (cytochrome c)" XP_046745297.1 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" XP_046747810.1 7 MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00240+2.7.4.14;KEGG: 00230+2.7.4.3;KEGG: 00983+2.7.4.14;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7176 "Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine metabolism";"Purine metabolism";"Drug metabolism - other enzymes";"Thiamine metabolism";"UTP and CTP de novo biosynthesis" XP_046742997.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046740179.1 3 Reactome: R-HSA-391160;KEGG: 04660+2.7.10.2;Reactome: R-HSA-4420097 "Signal regulatory protein family interactions";"T cell receptor signaling pathway";"VEGFA-VEGFR2 Pathway" XP_046747083.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046747923.1 7 Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes" XP_046745717.1 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" XP_046747693.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046739167.1 2 Reactome: R-HSA-399719;Reactome: R-HSA-190873 "Trafficking of AMPA receptors";"Gap junction degradation" XP_046750779.1 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" XP_046744791.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046735300.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046752465.1 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" XP_046737088.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046747338.1 57 Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5658442;Reactome: R-HSA-6798695;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-5607761;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-1236974;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684 "Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of RAS by GAPs";"Neutrophil degranulation";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"ER-Phagosome pathway";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"Hedgehog 'on' state" XP_046739783.1 4 Reactome: R-HSA-2500257;Reactome: R-HSA-2470946;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052 "Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion" XP_046750834.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046735051.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046739557.1 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" XP_046743526.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046746969.1 7 KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046743072.1 4 Reactome: R-HSA-5625970;Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "RHO GTPases activate KTN1";"MHC class II antigen presentation";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046736212.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046752131.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046741471.1 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" XP_046742935.1 2 Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198 "Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis" XP_046740693.1 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" XP_046740556.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046753849.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046736633.1 6 KEGG: 00680+2.6.1.52;KEGG: 00260+2.6.1.52;Reactome: R-HSA-977347;KEGG: 00750+2.6.1.52;MetaCyc: PWY-8010;KEGG: 00270+2.6.1.52 "Methane metabolism";"Glycine, serine and threonine metabolism";"Serine biosynthesis";"Vitamin B6 metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Cysteine and methionine metabolism" XP_046747432.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046743854.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046740594.1 7 KEGG: 00010+1.2.4.1;KEGG: 00020+1.2.4.1;Reactome: R-HSA-204174;Reactome: R-HSA-70268;Reactome: R-HSA-389661;Reactome: R-HSA-5362517;KEGG: 00620+1.2.4.1 "Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Signaling by Retinoic Acid";"Pyruvate metabolism" XP_046750244.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046750645.1 5 Reactome: R-HSA-381038;Reactome: R-HSA-901032;Reactome: R-HSA-5362768;MetaCyc: PWY-7511;Reactome: R-HSA-5358346 "XBP1(S) activates chaperone genes";"ER Quality Control Compartment (ERQC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Protein ubiquitination";"Hedgehog ligand biogenesis" XP_046753481.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046747023.1 11 Reactome: R-HSA-450302;Reactome: R-HSA-4420097;KEGG: 05165+2.7.11.1;Reactome: R-HSA-171007;KEGG: 04926+2.7.11.1;Reactome: R-HSA-2559580;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "activated TAK1 mediates p38 MAPK activation";"VEGFA-VEGFR2 Pathway";"Human papillomavirus infection";"p38MAPK events";"Relaxin signaling pathway";"Oxidative Stress Induced Senescence";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046753237.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046743438.1 7 Reactome: R-HSA-6798695;Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-373753;Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-264870 "Neutrophil degranulation";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Nephrin family interactions";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"Caspase-mediated cleavage of cytoskeletal proteins" XP_046753300.1 19 Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-9649948;Reactome: R-HSA-438066;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5576892;Reactome: R-HSA-5673000;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692 "Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"Signaling downstream of RAS mutants";"Unblocking of NMDA receptors, glutamate binding and activation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"Phase 0 - rapid depolarisation";"RAF activation";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity" XP_046745222.1 2 Reactome: R-HSA-9610379;Reactome: R-HSA-917729 "HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)" XP_046742562.1 12 Reactome: R-HSA-72702;Reactome: R-HSA-429947;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-450408;Reactome: R-HSA-166208;Reactome: R-HSA-72662;Reactome: R-HSA-1169408;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956 "Ribosomal scanning and start codon recognition";"Deadenylation of mRNA";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"mTORC1-mediated signalling";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"ISG15 antiviral mechanism";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" XP_046736505.1 7 Reactome: R-HSA-2122948;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-2660826;Reactome: R-HSA-2979096;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507 "Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus" XP_046736385.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046743017.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-6783310 "Protein ubiquitination";"Fanconi Anemia Pathway" XP_046747569.1 2 Reactome: R-HSA-749476;Reactome: R-HSA-73980 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination" XP_046742735.1 2 Reactome: R-HSA-9029569;Reactome: R-HSA-804914 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transport of fatty acids" XP_046734689.1 3 Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046750291.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046748481.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046740391.1 1 Reactome: R-HSA-947581 "Molybdenum cofactor biosynthesis" XP_046753523.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046750170.1 1 Reactome: R-HSA-70171 "Glycolysis" XP_046744060.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046736035.1 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046740452.1 2 Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13 "Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system" XP_046734501.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046737405.1 13 Reactome: R-HSA-419037;Reactome: R-HSA-216083;Reactome: R-HSA-1650814;Reactome: R-HSA-2214320;Reactome: R-HSA-1474244;Reactome: R-HSA-2022090;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216;Reactome: R-HSA-3000157;Reactome: R-HSA-3000178;Reactome: R-HSA-2243919;Reactome: R-HSA-186797;Reactome: R-HSA-3000171 "NCAM1 interactions";"Integrin cell surface interactions";"Collagen biosynthesis and modifying enzymes";"Anchoring fibril formation";"Extracellular matrix organization";"Assembly of collagen fibrils and other multimeric structures";"Collagen degradation";"Collagen chain trimerization";"Laminin interactions";"ECM proteoglycans";"Crosslinking of collagen fibrils";"Signaling by PDGF";"Non-integrin membrane-ECM interactions" XP_046752812.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway" XP_046738620.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046753944.1 1 Reactome: R-HSA-8849932 "Synaptic adhesion-like molecules" XP_046737509.1 1 Reactome: R-HSA-9022692 "Regulation of MECP2 expression and activity" XP_046733724.1 4 Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.6;Reactome: R-HSA-379726 "Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" XP_046743204.1 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" XP_046744212.1 12 Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878 "Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport" XP_046741303.1 3 Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation" XP_046736811.1 5 Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-75035;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes" XP_046737608.1 8 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6791226 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046752859.1 3 MetaCyc: PWY-2161;Reactome: R-HSA-196757;KEGG: 00790+6.3.2.17 "Folate polyglutamylation";"Metabolism of folate and pterines";"Folate biosynthesis" XP_046734098.1 3 MetaCyc: PWY-7807;MetaCyc: PWY-7805;KEGG: 00190+3.6.1.1 "Glyphosate degradation III";"(aminomethyl)phosphonate degradation";"Oxidative phosphorylation" XP_046737822.1 1 Reactome: R-HSA-163765 "ChREBP activates metabolic gene expression" XP_046736743.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046734523.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046746196.1 3 Reactome: R-HSA-6798695;MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Neutrophil degranulation";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046736276.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046736105.1 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" XP_046751068.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046750745.1 13 Reactome: R-HSA-9649948;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5674135;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6802948;Reactome: R-HSA-6802946;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1 "Signaling downstream of RAS mutants";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Human papillomavirus infection";"Relaxin signaling pathway";"MAP2K and MAPK activation";"Human cytomegalovirus infection";"Signaling by high-kinase activity BRAF mutants";"Signaling by moderate kinase activity BRAF mutants";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway" XP_046752333.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046747342.1 1 Reactome: R-HSA-75153 "Apoptotic execution phase" XP_046739919.1 5 Reactome: R-HSA-3214858;Reactome: R-HSA-1266695;Reactome: R-HSA-3247509;Reactome: R-HSA-8939243;Reactome: R-HSA-201722 "RMTs methylate histone arginines";"Interleukin-7 signaling";"Chromatin modifying enzymes";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex" XP_046738309.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046736387.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046749679.1 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" XP_046747855.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046738243.1 2 Reactome: R-HSA-74217;KEGG: 00230+1.7.1.7 "Purine salvage";"Purine metabolism" XP_046734496.1 12 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-416482;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-193648;Reactome: R-HSA-418885;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-194840;Reactome: R-HSA-416476 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"G alpha (12/13) signalling events";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"NRAGE signals death through JNK";"DCC mediated attractive signaling";"Relaxin signaling pathway";"Human papillomavirus infection";"Rho GTPase cycle";"G alpha (q) signalling events" XP_046742433.1 8 KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00500+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00010+2.7.1.1 "Streptomycin biosynthesis";"Glycolysis";"Starch and sucrose metabolism";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Galactose metabolism";"Glycolysis / Gluconeogenesis" XP_046753341.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046748716.1 7 Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes" XP_046735977.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046750928.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046750790.1 2 KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685 "Glutathione metabolism";"Detoxification of Reactive Oxygen Species" XP_046745915.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046753161.1 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" XP_046745924.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046749787.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046736687.1 4 Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862 "NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants" XP_046748947.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046745447.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046733994.1 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" XP_046740656.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046743191.1 5 MetaCyc: PWY-7511;Reactome: R-HSA-4641257;Reactome: R-HSA-201681;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880 "Protein ubiquitination";"Degradation of AXIN";"TCF dependent signaling in response to WNT";"Regulation of PTEN stability and activity";"Ub-specific processing proteases" XP_046745752.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-6807505 "mRNA Splicing - Major Pathway";"RNA polymerase II transcribes snRNA genes" XP_046743772.1 1 Reactome: R-HSA-2565942 "Regulation of PLK1 Activity at G2/M Transition" XP_046737979.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046746657.1 27 Reactome: R-HSA-72187;Reactome: R-HSA-975957;Reactome: R-HSA-77588;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-975956;Reactome: R-HSA-6803529;Reactome: R-HSA-9010553;Reactome: R-HSA-112382;Reactome: R-HSA-167158;Reactome: R-HSA-159230;Reactome: R-HSA-73856;Reactome: R-HSA-191859;Reactome: R-HSA-77595;Reactome: R-HSA-72163;Reactome: R-HSA-159227;Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-167200;Reactome: R-HSA-111367;Reactome: R-HSA-159236;Reactome: R-HSA-72203;Reactome: R-HSA-72086;Reactome: R-HSA-72165;Reactome: R-HSA-113418;Reactome: R-HSA-8851708;Reactome: R-HSA-159231 "mRNA 3'-end processing";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"FGFR2 alternative splicing";"Regulation of expression of SLITs and ROBOs";"Formation of RNA Pol II elongation complex";"Formation of the HIV-1 Early Elongation Complex";"Transport of the SLBP Dependant Mature mRNA";"RNA Polymerase II Transcription Termination";"snRNP Assembly";"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway";"Transport of the SLBP independent Mature mRNA";"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"SLBP independent Processing of Histone Pre-mRNAs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Processing of Capped Intron-Containing Pre-mRNA";"mRNA Capping";"mRNA Splicing - Minor Pathway";"Formation of the Early Elongation Complex";"Signaling by FGFR2 IIIa TM";"Transport of Mature mRNA Derived from an Intronless Transcript" XP_046752127.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046735166.1 14 MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7724;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-7601;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598 "Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis" XP_046739582.1 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" XP_046734873.1 2 Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24 "Lysosomal oligosaccharide catabolism";"Other glycan degradation" XP_046735956.1 6 MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817 "Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046747017.1 11 Reactome: R-HSA-450302;KEGG: 05165+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;KEGG: 04926+2.7.11.1;Reactome: R-HSA-2559580;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "activated TAK1 mediates p38 MAPK activation";"Human papillomavirus infection";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"Relaxin signaling pathway";"Oxidative Stress Induced Senescence";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046740822.1 3 KEGG: 00860+2.5.1.141;MetaCyc: PWY-7856;Reactome: R-HSA-189451 "Porphyrin and chlorophyll metabolism";"Heme a biosynthesis";"Heme biosynthesis" XP_046746834.1 13 Reactome: R-HSA-5689877;Reactome: R-HSA-532668;Reactome: R-HSA-382556;Reactome: R-HSA-6798695;Reactome: R-HSA-3371511;Reactome: R-HSA-8866654;Reactome: R-HSA-5358346;Reactome: R-HSA-9646399;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-5689896;Reactome: R-HSA-110320;Reactome: R-HSA-8876725 "Josephin domain DUBs";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"ABC-family proteins mediated transport";"Neutrophil degranulation";"HSF1 activation";"E3 ubiquitin ligases ubiquitinate target proteins";"Hedgehog ligand biogenesis";"Aggrephagy";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Ovarian tumor domain proteases";"Translesion Synthesis by POLH";"Protein methylation" XP_046740553.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046741609.1 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" XP_046738070.1 2 Reactome: R-HSA-74217;KEGG: 00230+1.7.1.7 "Purine salvage";"Purine metabolism" XP_046750228.1 24 KEGG: 05170+2.7.11.1;Reactome: R-HSA-5607764;Reactome: R-HSA-9634635;Reactome: R-HSA-5218921;KEGG: 04150+2.7.11.1;Reactome: R-HSA-444257;Reactome: R-HSA-6804757;Reactome: R-HSA-389357;Reactome: R-HSA-392451;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-165158;Reactome: R-HSA-354192;KEGG: 04151+2.7.11.1;Reactome: R-HSA-2730905;Reactome: R-HSA-5218920;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5625740;Reactome: R-HSA-1257604;Reactome: R-HSA-114604 "Human immunodeficiency virus 1 infection";"CLEC7A (Dectin-1) signaling";"Estrogen-stimulated signaling through PRKCZ";"VEGFR2 mediated cell proliferation";"mTOR signaling pathway";"RSK activation";"Regulation of TP53 Degradation";"CD28 dependent PI3K/Akt signaling";"G beta:gamma signalling through PI3Kgamma";"Human papillomavirus infection";"Relaxin signaling pathway";"Downstream TCR signaling";"FCERI mediated NF-kB activation";"Activation of AKT2";"Integrin signaling";"PI3K-Akt signaling pathway";"Role of LAT2/NTAL/LAB on calcium mobilization";"VEGFR2 mediated vascular permeability";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection";"Thermogenesis";"RHO GTPases activate PKNs";"PIP3 activates AKT signaling";"GPVI-mediated activation cascade" XP_046736834.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046742956.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046749043.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046745778.1 7 Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.36;Reactome: R-HSA-1855204;KEGG: 04070+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-8856828;Reactome: R-HSA-1660499 "Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Clathrin-mediated endocytosis";"Synthesis of PIPs at the plasma membrane" XP_046736389.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046744108.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046738977.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656 "Wax biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis" XP_046748221.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046747487.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046742031.1 5 Reactome: R-HSA-1368108;Reactome: R-HSA-6798695;MetaCyc: PWY-5381;Reactome: R-HSA-197264;KEGG: 00760+6.3.4.21 "BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Neutrophil degranulation";"Pyridine nucleotide cycling (plants)";"Nicotinamide salvaging";"Nicotinate and nicotinamide metabolism" XP_046736589.1 17 Reactome: R-HSA-1834949;Reactome: R-HSA-5693571;Reactome: R-HSA-5693616;Reactome: R-HSA-5693548;Reactome: R-HSA-5693565;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-3270619;Reactome: R-HSA-5685938;Reactome: R-HSA-2559586;Reactome: R-HSA-69473;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5685939 "Cytosolic sensors of pathogen-associated DNA";"Nonhomologous End-Joining (NHEJ)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Sensing of DNA Double Strand Breaks";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"IRF3-mediated induction of type I IFN";"HDR through Single Strand Annealing (SSA)";"DNA Damage/Telomere Stress Induced Senescence";"G2/M DNA damage checkpoint";"Meiotic recombination";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"HDR through MMEJ (alt-NHEJ)" XP_046748907.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046747931.1 5 Reactome: R-HSA-381426;Reactome: R-HSA-532668;Reactome: R-HSA-879415;Reactome: R-HSA-901042;Reactome: R-HSA-8957275 "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Advanced glycosylation endproduct receptor signaling";"Calnexin/calreticulin cycle";"Post-translational protein phosphorylation" XP_046749762.1 7 Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288 "mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Macroautophagy";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1" XP_046734058.1 13 KEGG: 00982+2.5.1.18;MetaCyc: PWY-7533;MetaCyc: PWY-7112;MetaCyc: PWY-4061;KEGG: 00980+2.5.1.18;KEGG: 00983+2.5.1.18;MetaCyc: PWY-2261;MetaCyc: PWY-6842;MetaCyc: PWY-6370;Reactome: R-HSA-196836;Reactome: R-HSA-156590;KEGG: 00053+1.8.5.1;KEGG: 00480+2.5.1.18+1.8.5.1 "Drug metabolism - cytochrome P450";"Gliotoxin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I";"Metabolism of xenobiotics by cytochrome P450";"Drug metabolism - other enzymes";"Ascorbate glutathione cycle";"Glutathione-mediated detoxification II";"Ascorbate recycling (cytosolic)";"Vitamin C (ascorbate) metabolism";"Glutathione conjugation";"Ascorbate and aldarate metabolism";"Glutathione metabolism" XP_046749832.1 1 Reactome: R-HSA-156581 "Methylation" XP_046741677.1 2 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.21 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046734350.1 2 Reactome: R-HSA-532668;KEGG: 00511+3.2.1.96 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Other glycan degradation" XP_046740100.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046739446.1 6 KEGG: 05235+3.1.3.16;Reactome: R-HSA-163560;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-400253;Reactome: R-HSA-2173788 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"Triglyceride catabolism";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"Circadian Clock";"Downregulation of TGF-beta receptor signaling" XP_046747648.1 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046738145.1 2 Reactome: R-HSA-382556;Reactome: R-HSA-5678895 "ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis" XP_046735772.1 1 Reactome: R-HSA-196108 "Pregnenolone biosynthesis" XP_046746622.1 24 Reactome: R-HSA-5610787;Reactome: R-HSA-9010642;Reactome: R-HSA-164378;Reactome: R-HSA-5687128;Reactome: R-HSA-422356;KEGG: 04150+2.7.11.11;Reactome: R-HSA-392517;Reactome: R-HSA-163615;Reactome: R-HSA-111931;Reactome: R-HSA-442720;Reactome: R-HSA-381676;Reactome: R-HSA-5621575;Reactome: R-HSA-163560;Reactome: R-HSA-983231;Reactome: R-HSA-4420097;Reactome: R-HSA-8853659;Reactome: R-HSA-432040;Reactome: R-HSA-5610780;Reactome: R-HSA-180024;Reactome: R-HSA-163358;Reactome: R-HSA-5610783;Reactome: R-HSA-5610785;Reactome: R-HSA-8963896;Reactome: R-HSA-9634600 "Hedgehog 'off' state";"ROBO receptors bind AKAP5";"PKA activation in glucagon signalling";"MAPK6/MAPK4 signaling";"Regulation of insulin secretion";"mTOR signaling pathway";"Rap1 signalling";"PKA activation";"PKA-mediated phosphorylation of CREB";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"CD209 (DC-SIGN) signaling";"Triglyceride catabolism";"Factors involved in megakaryocyte development and platelet production";"VEGFA-VEGFR2 Pathway";"RET signaling";"Vasopressin regulates renal water homeostasis via Aquaporins";"Degradation of GLI1 by the proteasome";"DARPP-32 events";"PKA-mediated phosphorylation of key metabolic factors";"Degradation of GLI2 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"HDL assembly";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" XP_046741569.1 13 Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" XP_046751972.1 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" XP_046742219.1 3 Reactome: R-HSA-2206282;KEGG: 00531+3.2.1.50;Reactome: R-HSA-2024096 "MPS IIIB - Sanfilippo syndrome B";"Glycosaminoglycan degradation";"HS-GAG degradation" XP_046751352.1 14 Reactome: R-HSA-1483166;MetaCyc: PWY-7782;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7411;MetaCyc: PWY-7417;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7589;KEGG: 00564+2.3.1.51;MetaCyc: PWY-5667;MetaCyc: PWY-7587;MetaCyc: PWY-8051;MetaCyc: PWY-6453 "Synthesis of PA";"Plasmalogen biosynthesis";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis I";"Stigma estolide biosynthesis" XP_046743674.1 7 MetaCyc: PWY-6824;MetaCyc: PWY-5469;MetaCyc: PWY-7445;MetaCyc: PWY-7214;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461;MetaCyc: PWY-5466 "Justicidin B biosynthesis";"Sesamin biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Phenylpropanoid biosynthesis";"Betanidin degradation";"Matairesinol biosynthesis" XP_046743026.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046734661.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046738835.1 14 KEGG: 00592+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7416;MetaCyc: PWY-8053;Reactome: R-HSA-1482788;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;Reactome: R-HSA-975634;KEGG: 00591+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4 "alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PC";"Plasmalogen degradation";"Arachidonic acid metabolism";"Glycerophospholipid metabolism";"Retinoid metabolism and transport";"Linoleic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism" XP_046739782.1 4 Reactome: R-HSA-2500257;Reactome: R-HSA-2470946;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052 "Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion" XP_046737833.1 5 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-6784531;Reactome: R-HSA-77595;Reactome: R-HSA-72163 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"tRNA processing in the nucleus";"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway" XP_046739510.1 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" XP_046739640.1 8 KEGG: 00030+5.3.1.6;MetaCyc: PWY-1861;Reactome: R-HSA-5659996;Reactome: R-HSA-6791461;KEGG: 00051+5.3.1.6;KEGG: 00710+5.3.1.6;MetaCyc: PWY-5723;Reactome: R-HSA-71336 "Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"RPIA deficiency: failed conversion of R5P to RU5P";"RPIA deficiency: failed conversion of RU5P to R5P";"Fructose and mannose metabolism";"Carbon fixation in photosynthetic organisms";"Rubisco shunt";"Pentose phosphate pathway" XP_046734348.1 1 Reactome: R-HSA-427601 "Multifunctional anion exchangers" XP_046748489.1 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" XP_046747323.1 3 Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-425561 "Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Sodium/Calcium exchangers" XP_046750175.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-3928662;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation" XP_046734783.1 1 Reactome: R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" XP_046741047.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046749505.1 6 MetaCyc: PWY-6922;KEGG: 00330+2.6.1.13;MetaCyc: PWY-3341;Reactome: R-HSA-8964539;MetaCyc: PWY-4981;MetaCyc: PWY-6344 "L-Ndelta-acetylornithine biosynthesis";"Arginine and proline metabolism";"L-proline biosynthesis III (from L-ornithine)";"Glutamate and glutamine metabolism";"L-proline biosynthesis II (from arginine)";"L-ornithine degradation II (Stickland reaction)" XP_046753035.1 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046747877.1 3 MetaCyc: PWY-6829;Reactome: R-HSA-6782315;MetaCyc: PWY-7888 "Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol";"Trna-uridine 2-thiolation (cytoplasmic)" XP_046753896.1 2 KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749 "Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I" XP_046752391.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046738143.1 1 Reactome: R-HSA-201451 "Signaling by BMP" XP_046749420.1 5 KEGG: 00513+2.4.1.68;Reactome: R-HSA-975578;KEGG: 00510+2.4.1.68;KEGG: 00533+2.4.1.68;MetaCyc: PWY-7426 "Various types of N-glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway";"N-Glycan biosynthesis";"Glycosaminoglycan biosynthesis - keratan sulfate";"Complex N-linked glycan biosynthesis (vertebrates)" XP_046734004.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046738280.1 8 Reactome: R-HSA-9613354;Reactome: R-HSA-1632852;Reactome: R-HSA-2151209;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-6804756 "Lipophagy";"Macroautophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Regulation of TP53 Activity through Phosphorylation" XP_046747108.1 1 Reactome: R-HSA-399956 "CRMPs in Sema3A signaling" XP_046750883.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046735126.1 27 Reactome: R-HSA-5619107;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-3108214;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-165054 "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"HCMV Late Events";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA" XP_046744754.1 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" XP_046739878.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046737993.1 2 Reactome: R-HSA-375281;Reactome: R-HSA-418555 "Hormone ligand-binding receptors";"G alpha (s) signalling events" XP_046743555.1 10 MetaCyc: PWY-5484;MetaCyc: PWY-1042;KEGG: 00710+5.3.1.1;MetaCyc: PWY-6142;KEGG: 00051+5.3.1.1;KEGG: 00562+5.3.1.1;MetaCyc: PWY-7003;Reactome: R-HSA-70171;Reactome: R-HSA-70263;KEGG: 00010+5.3.1.1 "Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Fructose and mannose metabolism";"Inositol phosphate metabolism";"Glycerol degradation to butanol";"Glycolysis";"Gluconeogenesis";"Glycolysis / Gluconeogenesis" XP_046739291.1 5 Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-983712 "Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Ion channel transport" XP_046748191.1 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" XP_046740794.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046746229.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046739163.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046742771.1 3 MetaCyc: PWY-5129;KEGG: 00600+1.14.19.17;Reactome: R-HSA-1660661 "Sphingolipid biosynthesis (plants)";"Sphingolipid metabolism";"Sphingolipid de novo biosynthesis" XP_046742691.1 1 Reactome: R-HSA-6804754 "Regulation of TP53 Expression" XP_046753929.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046753791.1 3 KEGG: 00643+1.13.11.5;Reactome: R-HSA-8963684;KEGG: 00350+1.13.11.5 "Styrene degradation";"Tyrosine catabolism";"Tyrosine metabolism" XP_046741737.1 3 KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348 "Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition" XP_046734374.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046754140.1 1 Reactome: R-HSA-5617833 "Cilium Assembly" XP_046753516.1 2 Reactome: R-HSA-3108214;Reactome: R-HSA-5685938 "SUMOylation of DNA damage response and repair proteins";"HDR through Single Strand Annealing (SSA)" XP_046739677.1 1 Reactome: R-HSA-196741 "Cobalamin (Cbl, vitamin B12) transport and metabolism" XP_046752449.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046753241.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046744826.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046747322.1 3 Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148 "Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046747096.1 9 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6804756 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"tRNA modification in the nucleus and cytosol";"Relaxin signaling pathway";"Human papillomavirus infection";"Regulation of TP53 Activity through Phosphorylation" XP_046740267.1 4 Reactome: R-HSA-1632852;Reactome: R-HSA-936440;Reactome: R-HSA-8934903;Reactome: R-HSA-5205685 "Macroautophagy";"Negative regulators of DDX58/IFIH1 signaling";"Receptor Mediated Mitophagy";"Pink/Parkin Mediated Mitophagy" XP_046753755.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046735132.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046744274.1 12 Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690 "EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events" XP_046744827.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046739833.1 1 Reactome: R-HSA-5693565 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" XP_046752623.1 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" XP_046746083.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046735719.1 7 Reactome: R-HSA-210500;KEGG: 00471+3.5.1.2;KEGG: 00250+3.5.1.2;MetaCyc: PWY-5921;Reactome: R-HSA-8964539;KEGG: 00220+3.5.1.2;Reactome: R-HSA-5628897 "Glutamate Neurotransmitter Release Cycle";"D-Glutamine and D-glutamate metabolism";"Alanine, aspartate and glutamate metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate and glutamine metabolism";"Arginine biosynthesis";"TP53 Regulates Metabolic Genes" XP_046744116.1 3 MetaCyc: PWY-7800;MetaCyc: PWY-7799;Reactome: R-HSA-2514859 "Ac/N-end rule pathway";"Arg/N-end rule pathway (eukaryotic)";"Inactivation, recovery and regulation of the phototransduction cascade" XP_046744973.1 20 MetaCyc: PWY-6837;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7291;MetaCyc: PWY-5136;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7007;MetaCyc: PWY-7854;MetaCyc: PWY-7337;MetaCyc: PWY-7606;KEGG: 00640+1.3.3.6;MetaCyc: PWY-6920;MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7338;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7574;MetaCyc: PWY-7726;MetaCyc: PWY-7858;Reactome: R-HSA-9033241;MetaCyc: PWY-735 "Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Fatty acid degradation";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation II (plant peroxisome)";"beta-Alanine metabolism";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Propanoate metabolism";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"alpha-Linolenic acid metabolism";"Propanoyl-coa degradation II";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"(5Z)-dodecenoate biosynthesis II";"Peroxisomal protein import";"Jasmonic acid biosynthesis" XP_046743927.1 12 KEGG: 00052+2.7.7.9;MetaCyc: PWY-7238;KEGG: 00040+2.7.7.9;KEGG: 00520+2.7.7.9;Reactome: R-HSA-173599;Reactome: R-HSA-3322077;MetaCyc: PWY-6527;KEGG: 00561+2.7.7.9;MetaCyc: PWY-3801;KEGG: 00500+2.7.7.9;MetaCyc: PWY-7343;MetaCyc: PWY-7817 "Galactose metabolism";"Sucrose biosynthesis II";"Pentose and glucuronate interconversions";"Amino sugar and nucleotide sugar metabolism";"Formation of the active cofactor, UDP-glucuronate";"Glycogen synthesis";"Stachyose degradation";"Glycerolipid metabolism";"Sucrose degradation II (sucrose synthase)";"Starch and sucrose metabolism";"UDP-alpha-D-glucose biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046745420.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046752909.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046738321.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046746680.1 22 MetaCyc: PWY-7592;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7049;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5353;MetaCyc: PWY-7036;MetaCyc: PWY-6958;MetaCyc: PWY-7601;MetaCyc: PWY-7726;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-7727;MetaCyc: PWY-7606;MetaCyc: PWY-7053;MetaCyc: PWY-7728;MetaCyc: PWY-7619;Reactome: R-HSA-75876 "Arachidonate biosynthesis III (6-desaturase, mammals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs" XP_046743446.1 11 Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-8854518 "Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"AURKA Activation by TPX2" XP_046736423.1 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" XP_046737738.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046735780.1 1 Reactome: R-HSA-2514853 "Condensation of Prometaphase Chromosomes" XP_046742399.1 5 Reactome: R-HSA-2426168;Reactome: R-HSA-381183;Reactome: R-HSA-9614657;Reactome: R-HSA-380994;Reactome: R-HSA-1989781 "Activation of gene expression by SREBF (SREBP)";"ATF6 (ATF6-alpha) activates chaperone genes";"FOXO-mediated transcription of cell death genes";"ATF4 activates genes in response to endoplasmic reticulum stress";"PPARA activates gene expression" XP_046746301.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046751093.1 7 Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-76061 "RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" XP_046748905.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046752632.1 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" XP_046739685.1 3 Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-8963901 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Chylomicron remodeling" XP_046745038.1 2 Reactome: R-HSA-379716;Reactome: R-HSA-2408522 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism" XP_046753297.1 5 Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-69473;Reactome: R-HSA-5693565;Reactome: R-HSA-5689901 "Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Metalloprotease DUBs" XP_046752507.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046737901.1 24 Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878;Reactome: R-HSA-983189 "Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Separation of Sister Chromatids";"Cilium Assembly";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport";"Kinesins" XP_046747014.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046743610.1 7 MetaCyc: PWY-7886;MetaCyc: PWY-7818;MetaCyc: PWY-7782;KEGG: 00564+2.7.1.32+2.7.1.82;Reactome: R-HSA-1483213;Reactome: R-HSA-1483191;MetaCyc: PWY-3385 "Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)";"Plasmalogen biosynthesis";"Glycerophospholipid metabolism";"Synthesis of PE";"Synthesis of PC";"Choline biosynthesis I" XP_046740989.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046733961.1 15 Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-112382;Reactome: R-HSA-9603505;Reactome: R-HSA-167290;Reactome: R-HSA-113418 "TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Formation of RNA Pol II elongation complex";"NTRK3 as a dependence receptor";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex" XP_046753962.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046737091.1 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" XP_046744818.1 5 Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-6804758 "RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"Regulation of TP53 Activity through Acetylation" XP_046737893.1 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" XP_046745073.1 13 Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression" XP_046746257.1 4 Reactome: R-HSA-9646399;Reactome: R-HSA-9613829;Reactome: R-HSA-3899300;Reactome: R-HSA-9615710 "Aggrephagy";"Chaperone Mediated Autophagy";"SUMOylation of transcription cofactors";"Late endosomal microautophagy" XP_046750405.1 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" XP_046745537.1 4 Reactome: R-HSA-1268020;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial protein import";"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046734063.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046753189.1 5 KEGG: 00250+2.6.1.16;MetaCyc: PWY-8013;KEGG: 00520+2.6.1.16;MetaCyc: PWY-6749;Reactome: R-HSA-446210 "Alanine, aspartate and glutamate metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I";"Synthesis of UDP-N-acetyl-glucosamine" XP_046738905.1 14 KEGG: 00591+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-8051;MetaCyc: PWY-6803;Reactome: R-HSA-1482788;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-7417;MetaCyc: PWY-7416;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4 "Linoleic acid metabolism";"Retinoid metabolism and transport";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PC";"Glycerophospholipid metabolism";"Arachidonic acid metabolism";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism" XP_046748618.1 1 KEGG: 00970+6.1.1.16 "Aminoacyl-tRNA biosynthesis" XP_046751298.1 7 Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912 "Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane" XP_046750884.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046745002.1 14 Reactome: R-HSA-5620912;Reactome: R-HSA-141444;Reactome: R-HSA-380320;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-380270;Reactome: R-HSA-9648025;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-2500257 "Anchoring of the basal body to the plasma membrane";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Recruitment of NuMA to mitotic centrosomes";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Recruitment of mitotic centrosome proteins and complexes";"EML4 and NUDC in mitotic spindle formation";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Resolution of Sister Chromatid Cohesion" XP_046742140.1 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" XP_046751374.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046738179.1 7 Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-4615885;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"SUMOylation of DNA replication proteins";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" XP_046751625.1 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" XP_046747492.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046748698.1 6 MetaCyc: PWY-5381;MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1 "Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism" XP_046740247.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046744205.1 12 Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" XP_046746237.1 6 MetaCyc: PWY-7900;MetaCyc: PWY-622;MetaCyc: PWY-5067;Reactome: R-HSA-3878781;Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.18 "Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch biosynthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen storage disease type IV (GBE1)";"Glycogen synthesis";"Starch and sucrose metabolism" XP_046736943.1 6 Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046748504.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046748179.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046735324.1 2 KEGG: 00970+6.1.1.1;Reactome: R-HSA-379726 "Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" XP_046752395.1 7 MetaCyc: PWY-6692;KEGG: 00190+7.1.1.2;MetaCyc: PWY-4302;Reactome: R-HSA-611105;Reactome: R-HSA-6799198;MetaCyc: PWY-5083;MetaCyc: PWY-3781 "Fe(II) oxidation";"Oxidative phosphorylation";"Aerobic respiration III (alternative oxidase pathway)";"Respiratory electron transport";"Complex I biogenesis";"NAD/NADH phosphorylation and dephosphorylation";"Aerobic respiration I (cytochrome c)" XP_046753871.1 4 Reactome: R-HSA-2132295;Reactome: R-HSA-6811434;Reactome: R-HSA-68884;Reactome: R-HSA-983189 "MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic";"Mitotic Telophase/Cytokinesis";"Kinesins" XP_046744256.1 12 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic" XP_046746841.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046743625.1 1 Reactome: R-HSA-8866654 "E3 ubiquitin ligases ubiquitinate target proteins" XP_046736036.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046743647.1 3 Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369 "Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis" XP_046744773.1 8 Reactome: R-HSA-9639288;Reactome: R-HSA-3371571;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-8943724;Reactome: R-HSA-165159 "Amino acids regulate mTORC1";"HSF1-dependent transactivation";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"Macroautophagy";"Regulation of PTEN gene transcription";"mTOR signalling" XP_046752099.1 4 Reactome: R-HSA-6814122;Reactome: R-HSA-418594;Reactome: R-HSA-112043;Reactome: R-HSA-202040 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events";"PLC beta mediated events";"G-protein activation" XP_046747516.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046750129.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046744978.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046734772.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046735147.1 1 Reactome: R-HSA-611105 "Respiratory electron transport" XP_046745117.1 16 Reactome: R-HSA-5603041;Reactome: R-HSA-166058;Reactome: R-HSA-5603037;Reactome: R-HSA-1257604;Reactome: R-HSA-975138;Reactome: R-HSA-3134963;Reactome: R-HSA-1810476;Reactome: R-HSA-5602498;Reactome: R-HSA-1236974;Reactome: R-HSA-975110;Reactome: R-HSA-5602680;Reactome: R-HSA-6811558;Reactome: R-HSA-975871;Reactome: R-HSA-975155;Reactome: R-HSA-209543;Reactome: R-HSA-9020702 "IRAK4 deficiency (TLR2/4)";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"IRAK4 deficiency (TLR5)";"PIP3 activates AKT signaling";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"RIP-mediated NFkB activation via ZBP1";"MyD88 deficiency (TLR2/4)";"ER-Phagosome pathway";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"MyD88 deficiency (TLR5)";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"MyD88 cascade initiated on plasma membrane";"MyD88 dependent cascade initiated on endosome";"p75NTR recruits signalling complexes";"Interleukin-1 signaling" XP_046742453.1 6 Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" XP_046736194.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046743657.1 10 Reactome: R-HSA-1632852;Reactome: R-HSA-2151209;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-9613354;Reactome: R-HSA-200425;Reactome: R-HSA-9619483;Reactome: R-HSA-163680;Reactome: R-HSA-6804756;Reactome: R-HSA-1445148 "Macroautophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Lipophagy";"Carnitine metabolism";"Activation of AMPK downstream of NMDARs";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046743165.1 9 Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-76042 "Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance" XP_046744810.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046748975.1 3 KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961;Reactome: R-HSA-196783 "Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis" XP_046744993.1 3 Reactome: R-HSA-1474228;Reactome: R-HSA-1592389;Reactome: R-HSA-1442490 "Degradation of the extracellular matrix";"Activation of Matrix Metalloproteinases";"Collagen degradation" XP_046740667.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046742896.1 42 Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5625886;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-73728;Reactome: R-HSA-69473;Reactome: R-HSA-9609690;Reactome: R-HSA-110330;Reactome: R-HSA-2299718;Reactome: R-HSA-171306;Reactome: R-HSA-110328;Reactome: R-HSA-212300;Reactome: R-HSA-9018519;Reactome: R-HSA-3214847;Reactome: R-HSA-5693571;Reactome: R-HSA-3214815;Reactome: R-HSA-5334118;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-9610379;Reactome: R-HSA-977225;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-606279;Reactome: R-HSA-2559586;Reactome: R-HSA-1912408;Reactome: R-HSA-8936459;Reactome: R-HSA-3214858;Reactome: R-HSA-1221632;Reactome: R-HSA-427359;Reactome: R-HSA-3214842;Reactome: R-HSA-427413;Reactome: R-HSA-2559582;Reactome: R-HSA-2559580;Reactome: R-HSA-5578749;Reactome: R-HSA-5617472;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-73772;Reactome: R-HSA-5693565;Reactome: R-HSA-4551638 "Processing of DNA double-strand break ends";"Meiotic recombination";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"RNA Polymerase I Promoter Opening";"G2/M DNA damage checkpoint";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected purine";"Condensation of Prophase Chromosomes";"Packaging Of Telomere Ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"PRC2 methylates histones and DNA";"Estrogen-dependent gene expression";"HATs acetylate histones";"Nonhomologous End-Joining (NHEJ)";"HDACs deacetylate histones";"DNA methylation";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"HCMV Late Events";"Amyloid fiber formation";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere";"DNA Damage/Telomere Stress Induced Senescence";"Pre-NOTCH Transcription and Translation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RMTs methylate histone arginines";"Meiotic synapsis";"SIRT1 negatively regulates rRNA expression";"HDMs demethylate histones";"NoRC negatively regulates rRNA expression";"Senescence-Associated Secretory Phenotype (SASP)";"Oxidative Stress Induced Senescence";"Transcriptional regulation by small RNAs";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Escape";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"SUMOylation of chromatin organization proteins" XP_046739222.1 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" XP_046744444.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046751839.1 1 Reactome: R-HSA-9633012 "Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046735288.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046750852.1 2 Reactome: R-HSA-72165;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" XP_046742818.1 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046753607.1 10 Reactome: R-HSA-111458;Reactome: R-HSA-611105;Reactome: R-HSA-5628897;Reactome: R-HSA-111459;Reactome: R-HSA-2151201;Reactome: R-HSA-111464;Reactome: R-HSA-111463;Reactome: R-HSA-111457;Reactome: R-HSA-3299685;Reactome: R-HSA-9627069 "Formation of apoptosome";"Respiratory electron transport";"TP53 Regulates Metabolic Genes";"Activation of caspases through apoptosome-mediated cleavage";"Transcriptional activation of mitochondrial biogenesis";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"SMAC (DIABLO) binds to IAPs";"Release of apoptotic factors from the mitochondria";"Detoxification of Reactive Oxygen Species";"Regulation of the apoptosome activity" XP_046747004.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046748970.1 3 Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961 "Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II" XP_046746662.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046744680.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046750705.1 2 Reactome: R-HSA-4570571;Reactome: R-HSA-446193 "Defective RFT1 causes RFT1-CDG (CDG-1n)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" XP_046743899.1 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" XP_046736313.1 4 Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-112308;Reactome: R-HSA-5576893 "Phase 0 - rapid depolarisation";"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase" XP_046745823.1 2 MetaCyc: PWY-6981;KEGG: 00520+2.4.1.16 "Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism" XP_046745794.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046751311.1 2 Reactome: R-HSA-5619039;Reactome: R-HSA-426117 "Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)";"Cation-coupled Chloride cotransporters" XP_046747845.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046745821.1 6 MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817 "Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046741585.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" XP_046740877.1 2 KEGG: 00280+1.3.8.4;Reactome: R-HSA-70895 "Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism" XP_046752148.1 6 Reactome: R-HSA-5609978;MetaCyc: PWY-6317;Reactome: R-HSA-70370;KEGG: 00520+2.7.7.12;MetaCyc: PWY-6527;KEGG: 00052+2.7.7.12 "Defective GALT can cause Galactosemia";"D-galactose degradation I (Leloir pathway)";"Galactose catabolism";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"Galactose metabolism" XP_046748425.1 5 KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7921;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109 "Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis" XP_046746314.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046749030.1 7 MetaCyc: PWY-46;KEGG: 00330+3.5.3.1;MetaCyc: PWY-4984;MetaCyc: PWY-6922;MetaCyc: PWY-31;Reactome: R-HSA-70635;KEGG: 00220+3.5.3.1 "Putrescine biosynthesis III";"Arginine and proline metabolism";"Urea cycle";"L-Ndelta-acetylornithine biosynthesis";"Canavanine degradation";"Urea cycle";"Arginine biosynthesis" XP_046753286.1 2 Reactome: R-HSA-373080;Reactome: R-HSA-3238698 "Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking" XP_046747587.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046745476.1 5 Reactome: R-HSA-176407;Reactome: R-HSA-5687128;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"MAPK6/MAPK4 signaling";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046746118.1 9 Reactome: R-HSA-5678895;Reactome: R-HSA-8856828;Reactome: R-HSA-9613829;Reactome: R-HSA-5627083;Reactome: R-HSA-9646399;Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-5689880;Reactome: R-HSA-382556 "Defective CFTR causes cystic fibrosis";"Clathrin-mediated endocytosis";"Chaperone Mediated Autophagy";"RHO GTPases regulate CFTR trafficking";"Aggrephagy";"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Ub-specific processing proteases";"ABC-family proteins mediated transport" XP_046737281.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046747691.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046752837.1 2 Reactome: R-HSA-877300;Reactome: R-HSA-2132295 "Interferon gamma signaling";"MHC class II antigen presentation" XP_046738343.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046747097.1 9 KEGG: 05165+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"tRNA modification in the nucleus and cytosol";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046746798.1 1 Reactome: R-HSA-72203 "Processing of Capped Intron-Containing Pre-mRNA" XP_046749556.1 1 Reactome: R-HSA-6787450 "tRNA modification in the mitochondrion" XP_046742805.1 2 Reactome: R-HSA-975577;Reactome: R-HSA-2022854 "N-Glycan antennae elongation";"Keratan sulfate biosynthesis" XP_046753674.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046740333.1 6 Reactome: R-HSA-434316;Reactome: R-HSA-416476;Reactome: R-HSA-399997;Reactome: R-HSA-418592;Reactome: R-HSA-456926;Reactome: R-HSA-428930 "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G alpha (q) signalling events";"Acetylcholine regulates insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor" XP_046739760.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046748590.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046746578.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046736651.1 6 KEGG: 00270+2.6.1.52;KEGG: 00750+2.6.1.52;MetaCyc: PWY-8010;KEGG: 00260+2.6.1.52;Reactome: R-HSA-977347;KEGG: 00680+2.6.1.52 "Cysteine and methionine metabolism";"Vitamin B6 metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Glycine, serine and threonine metabolism";"Serine biosynthesis";"Methane metabolism" XP_046741149.1 3 Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" XP_046750844.1 5 Reactome: R-HSA-72163;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823 "mRNA Splicing - Major Pathway";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex" XP_046743188.1 4 KEGG: 00564+3.1.1.7;Reactome: R-HSA-1483191;Reactome: R-HSA-422085;Reactome: R-HSA-112311 "Glycerophospholipid metabolism";"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin";"Neurotransmitter clearance" XP_046746902.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-204005 "RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport" XP_046743894.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046734970.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046751370.1 1 Reactome: R-HSA-211981 "Xenobiotics" XP_046740050.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046745618.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046748384.1 27 Reactome: R-HSA-168276;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-3108214;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-5619107;Reactome: R-HSA-5578749;Reactome: R-HSA-180746 "NS1 Mediated Effects on Host Pathways";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Late Events";"SUMOylation of DNA replication proteins";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein" XP_046739186.1 7 Reactome: R-HSA-69202;Reactome: R-HSA-156711;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-1538133;Reactome: R-HSA-1362277;Reactome: R-HSA-69205 "Cyclin E associated events during G1/S transition";"Polo-like kinase mediated events";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G0 and Early G1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription" XP_046742412.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046753525.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046744182.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046740350.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046734684.1 3 Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046750732.1 1 Reactome: R-HSA-2514853 "Condensation of Prometaphase Chromosomes" XP_046741278.1 1 Reactome: R-HSA-8964038 "LDL clearance" XP_046747019.1 11 Reactome: R-HSA-450302;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;Reactome: R-HSA-2559580;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "activated TAK1 mediates p38 MAPK activation";"Relaxin signaling pathway";"Human papillomavirus infection";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"Oxidative Stress Induced Senescence";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046740485.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046743785.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046737480.1 7 Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518 "Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2" XP_046743831.1 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" XP_046746378.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046750756.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046741002.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046751194.1 57 Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-174113;Reactome: R-HSA-532668;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-450408;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-4641258;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-1236974;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684 "FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"SCF-beta-TrCP mediated degradation of Emi1";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Degradation of AXIN";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Degradation of DVL";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"ER-Phagosome pathway";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state" XP_046752355.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046752375.1 1 Reactome: R-HSA-163125 "Post-translational modification: synthesis of GPI-anchored proteins" XP_046751024.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046743697.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046740708.1 3 Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213 "Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs" XP_046737074.1 7 MetaCyc: PWY-7839;MetaCyc: PWY-7836;Reactome: R-HSA-1660662;MetaCyc: PWY-5129;MetaCyc: PWY-7841;MetaCyc: PWY-7838;KEGG: 00600+2.4.1.80 "Lacto-series glycosphingolipids biosynthesis";"Ganglio-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism";"Sphingolipid biosynthesis (plants)";"Neolacto-series glycosphingolipids biosynthesis";"Globo-series glycosphingolipids biosynthesis";"Sphingolipid metabolism" XP_046752828.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046744177.1 12 Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878 "Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport" XP_046740876.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046749599.1 13 Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975957 "Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046753492.1 2 Reactome: R-HSA-6784531;Reactome: R-HSA-6791226 "tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046748881.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046740126.1 3 Reactome: R-HSA-5250924;Reactome: R-HSA-72163;Reactome: R-HSA-72165 "B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" XP_046745550.1 2 Reactome: R-HSA-446193;Reactome: R-HSA-5633231 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)" XP_046739290.1 5 Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-917977 "Amino acids regulate mTORC1";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Ion channel transport";"Transferrin endocytosis and recycling" XP_046734408.1 1 Reactome: R-HSA-2028269 "Signaling by Hippo" XP_046753284.1 2 Reactome: R-HSA-3238698;Reactome: R-HSA-373080 "WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)" XP_046742339.1 3 Reactome: R-HSA-6804115;Reactome: R-HSA-5617472;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deadenylation of mRNA" XP_046738409.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046737019.1 4 Reactome: R-HSA-1614603;KEGG: 00270+4.2.1.22;KEGG: 00260+4.2.1.22;MetaCyc: PWY-801 "Cysteine formation from homocysteine";"Cysteine and methionine metabolism";"Glycine, serine and threonine metabolism";"Homocysteine and cysteine interconversion" XP_046734660.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046742040.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-7656;MetaCyc: PWY-6733;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782 "Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis" XP_046736723.1 1 Reactome: R-HSA-112308 "Presynaptic depolarization and calcium channel opening" XP_046753486.1 7 Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-606279;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Deposition of new CENPA-containing nucleosomes at the centromere";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins" XP_046734449.1 1 Reactome: R-HSA-5689603 "UCH proteinases" XP_046738305.1 1 Reactome: R-HSA-6790901 "rRNA modification in the nucleus and cytosol" XP_046733927.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046748621.1 5 KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527 "Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism";"Glycerolipid metabolism";"Stachyose degradation" XP_046750395.1 7 KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046751320.1 2 Reactome: R-HSA-426117;Reactome: R-HSA-5619039 "Cation-coupled Chloride cotransporters";"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)" XP_046738027.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046747493.1 1 Reactome: R-HSA-611105 "Respiratory electron transport" XP_046738705.1 10 Reactome: R-HSA-6814122;Reactome: R-HSA-201688;Reactome: R-HSA-2514853;Reactome: R-HSA-8939243;Reactome: R-HSA-8934903;Reactome: R-HSA-8948751;Reactome: R-HSA-6804756;Reactome: R-HSA-445144;Reactome: R-HSA-6798695;Reactome: R-HSA-1483191 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"WNT mediated activation of DVL";"Condensation of Prometaphase Chromosomes";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Receptor Mediated Mitophagy";"Regulation of PTEN stability and activity";"Regulation of TP53 Activity through Phosphorylation";"Signal transduction by L1";"Neutrophil degranulation";"Synthesis of PC" XP_046739763.1 24 Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295 "Mitotic Prometaphase";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"COPI-mediated anterograde transport";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Cilium Assembly";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases activate IQGAPs";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation" XP_046746050.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046743637.1 3 MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167 "Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol" XP_046748878.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046751740.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046739740.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046745634.1 11 Reactome: R-HSA-5610787;Reactome: R-HSA-418555;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-418597 "Hedgehog 'off' state";"G alpha (s) signalling events";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (i) signalling events";"Purine metabolism";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"G alpha (z) signalling events" XP_046746583.1 3 KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261;Reactome: R-HSA-75109 "Glycerolipid metabolism";"Glycerol degradation I";"Triglyceride biosynthesis" XP_046736355.1 2 KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7 "Pyruvate metabolism";"Aminobenzoate degradation" XP_046747360.1 12 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6804756;Reactome: R-HSA-9619483 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Regulation of TP53 Activity through Phosphorylation";"Activation of AMPK downstream of NMDARs" XP_046747942.1 2 Reactome: R-HSA-5339700;Reactome: R-HSA-4641265 "TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes" XP_046746795.1 13 Reactome: R-HSA-422356;Reactome: R-HSA-139853;Reactome: R-HSA-5607763;Reactome: R-HSA-5578775;Reactome: R-HSA-112043;Reactome: R-HSA-381676;Reactome: R-HSA-2871809;Reactome: R-HSA-4086398;Reactome: R-HSA-1489509;Reactome: R-HSA-983695;Reactome: R-HSA-5218921;Reactome: R-HSA-2029485;Reactome: R-HSA-114508 "Regulation of insulin secretion";"Elevation of cytosolic Ca2+ levels";"CLEC7A (Dectin-1) induces NFAT activation";"Ion homeostasis";"PLC beta mediated events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"FCERI mediated Ca+2 mobilization";"Ca2+ pathway";"DAG and IP3 signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"VEGFR2 mediated cell proliferation";"Role of phospholipids in phagocytosis";"Effects of PIP2 hydrolysis" XP_046735142.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046752450.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046734309.1 4 KEGG: 04660+3.1.3.16;Reactome: R-HSA-6807505;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"RNA polymerase II transcribes snRNA genes";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046744746.1 16 Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823 "Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation" XP_046734678.1 3 Reactome: R-HSA-9033241;Reactome: R-HSA-9603798;Reactome: R-HSA-8866654 "Peroxisomal protein import";"Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046734055.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046748452.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046753930.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046738035.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046749240.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046741872.1 3 MetaCyc: PWY-5067;Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.11 "Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen synthesis";"Starch and sucrose metabolism" XP_046746343.1 5 Reactome: R-HSA-8964539;MetaCyc: PWY-3341;KEGG: 00330+1.5.1.2;MetaCyc: PWY-6344;MetaCyc: PWY-4981 "Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)" XP_046749850.1 6 Reactome: R-HSA-400253;Reactome: R-HSA-2173788;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-163560;KEGG: 05235+3.1.3.16 "Circadian Clock";"Downregulation of TGF-beta receptor signaling";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"Triglyceride catabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046741068.1 1 Reactome: R-HSA-162658 "Golgi Cisternae Pericentriolar Stack Reorganization" XP_046751921.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046746470.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" XP_046733764.1 14 MetaCyc: PWY-7725;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7724;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7035 "Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis" XP_046745459.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046739990.1 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" XP_046753771.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046736741.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046751863.1 10 MetaCyc: PWY-7391;MetaCyc: PWY-7571;KEGG: 00280+2.3.3.10;MetaCyc: PWY-922;KEGG: 00072+2.3.3.10;Reactome: R-HSA-1989781;KEGG: 00650+2.3.3.10;MetaCyc: PWY-6174;KEGG: 00900+2.3.3.10;MetaCyc: PWY-7524 "Isoprene biosynthesis II (engineered)";"Ferrichrome A biosynthesis";"Valine, leucine and isoleucine degradation";"Mevalonate pathway I";"Synthesis and degradation of ketone bodies";"PPARA activates gene expression";"Butanoate metabolism";"Mevalonate pathway II (archaea)";"Terpenoid backbone biosynthesis";"Mevalonate pathway III (archaea)" XP_046735050.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046747893.1 20 Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-2644606;Reactome: R-HSA-2197563;Reactome: R-HSA-210744;Reactome: R-HSA-8941856;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-3214847;Reactome: R-HSA-9013695;Reactome: R-HSA-167172;Reactome: R-HSA-9013508;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-2122947;Reactome: R-HSA-75953;Reactome: R-HSA-73776 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 intracellular domain regulates transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"RUNX3 regulates NOTCH signaling";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HATs acetylate histones";"NOTCH4 Intracellular Domain Regulates Transcription";"Transcription of the HIV genome";"NOTCH3 Intracellular Domain Regulates Transcription";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"NOTCH1 Intracellular Domain Regulates Transcription";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape" XP_046736277.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046737202.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046735874.1 5 Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-983712 "Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Ion channel transport" XP_046743183.1 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" XP_046743944.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046742924.1 2 Reactome: R-HSA-804914;Reactome: R-HSA-9029569 "Transport of fatty acids";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" XP_046736910.1 3 Reactome: R-HSA-72163;Reactome: R-HSA-191859;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"snRNP Assembly";"mRNA Splicing - Minor Pathway" XP_046741000.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046743422.1 1 Reactome: R-HSA-425410 "Metal ion SLC transporters" XP_046747643.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046753088.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046751730.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046747807.1 12 MetaCyc: PWY-5855;MetaCyc: PWY-5856;Reactome: R-HSA-2142789;MetaCyc: PWY-5873;MetaCyc: PWY-6708;MetaCyc: PWY-5870;MetaCyc: PWY-5857;MetaCyc: PWY-5871;MetaCyc: PWY-5872;MetaCyc: PWY-6978;KEGG: 00130+2.5.1.39;Reactome: R-HSA-1268020 "Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinone and other terpenoid-quinone biosynthesis";"Mitochondrial protein import" XP_046743581.1 4 MetaCyc: PWY-8072;KEGG: 00473+5.1.1.1;MetaCyc: PWY-8040;MetaCyc: PWY-7383 "Alanine racemization";"D-Alanine metabolism";"Ansatrienin biosynthesis";"Anaerobic energy metabolism (invertebrates, cytosol)" XP_046753005.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046734514.1 3 Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081 "Non-integrin membrane-ECM interactions";"Laminin interactions";"MET activates PTK2 signaling" XP_046747640.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046745506.1 1 Reactome: R-HSA-8849175 "Threonine catabolism" XP_046737003.1 17 Reactome: R-HSA-69202;Reactome: R-HSA-9616222;Reactome: R-HSA-2559585;Reactome: R-HSA-8953750;Reactome: R-HSA-1912408;Reactome: R-HSA-2173796;Reactome: R-HSA-1538133;Reactome: R-HSA-113501;Reactome: R-HSA-69231;Reactome: R-HSA-2559580;Reactome: R-HSA-69656;Reactome: R-HSA-69205;Reactome: R-HSA-139915;Reactome: R-HSA-1362277;Reactome: R-HSA-6804114;Reactome: R-HSA-111448;Reactome: R-HSA-1362300 "Cyclin E associated events during G1/S transition";"Transcriptional regulation of granulopoiesis";"Oncogene Induced Senescence";"Transcriptional Regulation by E2F6";"Pre-NOTCH Transcription and Translation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G0 and Early G1";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Cyclin D associated events in G1";"Oxidative Stress Induced Senescence";"Cyclin A:Cdk2-associated events at S phase entry";"G1/S-Specific Transcription";"Activation of PUMA and translocation to mitochondria";"Transcription of E2F targets under negative control by DREAM complex";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Activation of NOXA and translocation to mitochondria";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" XP_046740854.1 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" XP_046740578.1 8 MetaCyc: PWY-5269;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;MetaCyc: PWY-5668;MetaCyc: PWY-7817;KEGG: 00564+3.1.3.27;KEGG: 05235+3.1.3.16;Reactome: R-HSA-1483148 "Cardiolipin biosynthesis II";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"Cardiolipin biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Synthesis of PG" XP_046752889.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046739148.1 29 Reactome: R-HSA-5693554;Reactome: R-HSA-6796648;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5685938;Reactome: R-HSA-6803207;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693571;Reactome: R-HSA-5693616;Reactome: R-HSA-5693548;Reactome: R-HSA-5693565;Reactome: R-HSA-349425;Reactome: R-HSA-5685942;Reactome: R-HSA-6803204;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-6804757;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-6804760;Reactome: R-HSA-3371453;Reactome: R-HSA-69541;KEGG: 04151+2.7.11.1;Reactome: R-HSA-2559586;KEGG: 05163+2.7.11.1;Reactome: R-HSA-69473;KEGG: 04714+2.7.11.1 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"TP53 Regulates Transcription of DNA Repair Genes";"Human papillomavirus infection";"Relaxin signaling pathway";"HDR through Single Strand Annealing (SSA)";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Nonhomologous End-Joining (NHEJ)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Sensing of DNA Double Strand Breaks";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Autodegradation of the E3 ubiquitin ligase COP1";"HDR through Homologous Recombination (HRR)";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Regulation of TP53 Degradation";"Meiotic recombination";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Regulation of TP53 Activity through Methylation";"Regulation of HSF1-mediated heat shock response";"Stabilization of p53";"PI3K-Akt signaling pathway";"DNA Damage/Telomere Stress Induced Senescence";"Human cytomegalovirus infection";"G2/M DNA damage checkpoint";"Thermogenesis" XP_046749379.1 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" XP_046738576.1 3 Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing" XP_046733883.1 9 Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-167162 "RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape" XP_046745354.1 2 Reactome: R-HSA-1296072;Reactome: R-HSA-5576894 "Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels" XP_046735149.1 1 Reactome: R-HSA-419771 "Opsins" XP_046746808.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046737839.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046751456.1 6 Reactome: R-HSA-159236;Reactome: R-HSA-975957;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-9010553;Reactome: R-HSA-72163 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway" XP_046740287.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046749756.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046751547.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046750633.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046748967.1 1 Reactome: R-HSA-189451 "Heme biosynthesis" XP_046735883.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046745903.1 3 Reactome: R-HSA-6783310;Reactome: R-HSA-5689880;Reactome: R-HSA-110314 "Fanconi Anemia Pathway";"Ub-specific processing proteases";"Recognition of DNA damage by PCNA-containing replication complex" XP_046749749.1 3 Reactome: R-HSA-6787450;Reactome: R-HSA-6785470;Reactome: R-HSA-8868766 "tRNA modification in the mitochondrion";"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion" XP_046753707.1 4 KEGG: 00983+6.3.5.2;Reactome: R-HSA-73817;KEGG: 00230+6.3.5.2;MetaCyc: PWY-7221 "Drug metabolism - other enzymes";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046739169.1 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" XP_046745584.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046752917.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-375276 "G alpha (q) signalling events";"Peptide ligand-binding receptors" XP_046733909.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046749562.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046741473.1 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" XP_046747409.1 6 Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706 "Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046742270.1 1 Reactome: R-HSA-428359 "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" XP_046754055.1 5 Reactome: R-HSA-1912420;Reactome: R-HSA-5083630;Reactome: R-HSA-1912408;Reactome: R-HSA-1912399;Reactome: R-HSA-350054 "Pre-NOTCH Processing in Golgi";"Defective LFNG causes SCDO3";"Pre-NOTCH Transcription and Translation";"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Notch-HLH transcription pathway" XP_046739016.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046733717.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046741705.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046747658.1 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" XP_046740370.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046737193.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" XP_046749991.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046737185.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-6803157 "Neutrophil degranulation";"Antimicrobial peptides" XP_046751940.1 2 Reactome: R-HSA-3214847;Reactome: R-HSA-5689880 "HATs acetylate histones";"Ub-specific processing proteases" XP_046753609.1 10 Reactome: R-HSA-611105;Reactome: R-HSA-111458;Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-5628897;Reactome: R-HSA-111459;Reactome: R-HSA-2151201;Reactome: R-HSA-3299685;Reactome: R-HSA-111457;Reactome: R-HSA-9627069 "Respiratory electron transport";"Formation of apoptosome";"SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"TP53 Regulates Metabolic Genes";"Activation of caspases through apoptosome-mediated cleavage";"Transcriptional activation of mitochondrial biogenesis";"Detoxification of Reactive Oxygen Species";"Release of apoptotic factors from the mitochondria";"Regulation of the apoptosome activity" XP_046743642.1 3 MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167 "Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol" XP_046733934.1 17 Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-6790901;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649 "Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"rRNA modification in the nucleus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation" XP_046748341.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" XP_046742043.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733 "Wax biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis" XP_046738720.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046737284.1 7 Reactome: R-HSA-2979096;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;MetaCyc: PWY-7511;Reactome: R-HSA-2122948;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862 "NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants" XP_046737179.1 19 KEGG: 00270+1.1.1.37;KEGG: 00630+1.1.1.37;KEGG: 00720+1.1.1.37;Reactome: R-HSA-70263;MetaCyc: PWY-6969;MetaCyc: PWY-5690;MetaCyc: PWY-561;MetaCyc: PWY-8086;KEGG: 00680+1.1.1.37;MetaCyc: PWY-7383;MetaCyc: PWY-6728;KEGG: 00710+1.1.1.37;MetaCyc: PWY-1622;Reactome: R-HSA-71403;MetaCyc: PWY-5392;KEGG: 00020+1.1.1.37;MetaCyc: PWY-5913;KEGG: 00620+1.1.1.37;MetaCyc: PWY-7115 "Cysteine and methionine metabolism";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle II (plants and fungi)";"Superpathway of glyoxylate cycle and fatty acid degradation";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Methane metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Methylaspartate cycle";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation I (serine pathway)";"Citric acid cycle (TCA cycle)";"Reductive TCA cycle II";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Pyruvate metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type" XP_046736806.1 5 Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897 "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes" XP_046749458.1 8 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"Activation of RAC1";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046750492.1 22 Reactome: R-HSA-2500257;Reactome: R-HSA-5675221;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-5358752;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-5467337;Reactome: R-HSA-2467813;Reactome: R-HSA-5358747;Reactome: R-HSA-5673000;Reactome: R-HSA-9648025;Reactome: R-HSA-5358751;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5467348;Reactome: R-HSA-196299;Reactome: R-HSA-6811558;Reactome: R-HSA-68877;Reactome: R-HSA-432142;Reactome: R-HSA-5663220;Reactome: R-HSA-5358749 "Resolution of Sister Chromatid Cohesion";"Negative regulation of MAPK pathway";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"T41 mutants of beta-catenin aren't phosphorylated";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"APC truncation mutants have impaired AXIN binding";"Separation of Sister Chromatids";"S33 mutants of beta-catenin aren't phosphorylated";"RAF activation";"EML4 and NUDC in mitotic spindle formation";"S45 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"Truncations of AMER1 destabilize the destruction complex";"Beta-catenin phosphorylation cascade";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Mitotic Prometaphase";"Platelet sensitization by LDL";"RHO GTPases Activate Formins";"S37 mutants of beta-catenin aren't phosphorylated" XP_046737243.1 32 Reactome: R-HSA-77075;Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-167246;Reactome: R-HSA-167238;Reactome: R-HSA-72163;Reactome: R-HSA-167287;Reactome: R-HSA-167161;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-72165;Reactome: R-HSA-113418;Reactome: R-HSA-8851708;Reactome: R-HSA-167172;Reactome: R-HSA-9018519;Reactome: R-HSA-6796648;Reactome: R-HSA-75953;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-76042;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-75955;Reactome: R-HSA-72203 "RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Major Pathway";"HIV elongation arrest and recovery";"HIV Transcription Initiation";"mRNA Capping";"Viral Messenger RNA Synthesis";"mRNA Splicing - Minor Pathway";"Formation of the Early Elongation Complex";"Signaling by FGFR2 IIIa TM";"Transcription of the HIV genome";"Estrogen-dependent gene expression";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Initiation";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Elongation";"Processing of Capped Intron-Containing Pre-mRNA" XP_046752893.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046753638.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046741437.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046750590.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046748745.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046747589.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046743006.1 14 Reactome: R-HSA-5685942;Reactome: R-HSA-110320;Reactome: R-HSA-110312;Reactome: R-HSA-110314;Reactome: R-HSA-5656121;Reactome: R-HSA-5656169;Reactome: R-HSA-69091;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-5655862;Reactome: R-HSA-5696397;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-6782210 "HDR through Homologous Recombination (HRR)";"Translesion Synthesis by POLH";"Translesion synthesis by REV1";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLI";"Termination of translesion DNA synthesis";"Polymerase switching";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Gap-filling DNA repair synthesis and ligation in TC-NER" XP_046738106.1 3 Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594 "Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events" XP_046752363.1 3 KEGG: 00480+4.3.2.9;Reactome: R-HSA-174403;MetaCyc: PWY-4041 "Glutathione metabolism";"Glutathione synthesis and recycling";"Gamma-glutamyl cycle" XP_046743670.1 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" XP_046751991.1 3 Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648 "Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK" XP_046741607.1 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" XP_046745958.1 6 Reactome: R-HSA-5545483;Reactome: R-HSA-5632987;Reactome: R-HSA-5358606;Reactome: R-HSA-912446;Reactome: R-HSA-5358565;Reactome: R-HSA-6796648 "Defective Mismatch Repair Associated With MLH1";"Defective Mismatch Repair Associated With PMS2";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Meiotic recombination";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"TP53 Regulates Transcription of DNA Repair Genes" XP_046739576.1 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" XP_046747818.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046736738.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046745635.1 11 Reactome: R-HSA-418597;Reactome: R-HSA-163615;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-170670;Reactome: R-HSA-5610787 "G alpha (z) signalling events";"PKA activation";"Purine metabolism";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state" XP_046750401.1 2 Reactome: R-HSA-975956;Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046737391.1 2 Reactome: R-HSA-5682910;Reactome: R-HSA-5250971 "LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)" XP_046743969.1 4 KEGG: 05235+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"DARPP-32 events";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway" XP_046736813.1 15 Reactome: R-HSA-3769402;Reactome: R-HSA-5467333;Reactome: R-HSA-5689896;Reactome: R-HSA-5339716;Reactome: R-HSA-5467340;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-111465;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747 "Deactivation of the beta-catenin transactivating complex";"APC truncation mutants are not K63 polyubiquitinated";"Ovarian tumor domain proteases";"Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Apoptotic cleavage of cellular proteins";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated" XP_046748696.1 6 MetaCyc: PWY-7761;MetaCyc: PWY-5381;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1;Reactome: R-HSA-196807 "NAD salvage pathway II (PNC IV cycle)";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism" XP_046745258.1 1 Reactome: R-HSA-9018519 "Estrogen-dependent gene expression" XP_046738715.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046735991.1 2 Reactome: R-HSA-1483152;Reactome: R-HSA-1483115 "Hydrolysis of LPE";"Hydrolysis of LPC" XP_046735932.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046735971.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046749650.1 8 KEGG: 00524+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00500+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00521+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00052+2.7.1.1 "Neomycin, kanamycin and gentamicin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Fructose and mannose metabolism";"Starch and sucrose metabolism";"Glycolysis";"Streptomycin biosynthesis";"Glycolysis / Gluconeogenesis";"Galactose metabolism" XP_046750586.1 1 Reactome: R-HSA-163560 "Triglyceride catabolism" XP_046742366.1 3 KEGG: 00643+3.7.1.2;KEGG: 00350+3.7.1.2;Reactome: R-HSA-8963684 "Styrene degradation";"Tyrosine metabolism";"Tyrosine catabolism" XP_046750481.1 6 Reactome: R-HSA-8951430;Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-4411364;Reactome: R-HSA-4641265;Reactome: R-HSA-4086398 "RUNX3 regulates WNT signaling";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Repression of WNT target genes";"Ca2+ pathway" XP_046751492.1 4 Reactome: R-HSA-189451;MetaCyc: PWY-5188;MetaCyc: PWY-5189;KEGG: 00860+2.5.1.61 "Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism" XP_046752354.1 5 Reactome: R-HSA-9627069;KEGG: 00270+4.2.1.109;MetaCyc: PWY-4361;Reactome: R-HSA-1237112;Reactome: R-HSA-111458 "Regulation of the apoptosome activity";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Methionine salvage pathway";"Formation of apoptosome" XP_046740926.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046737556.1 2 Reactome: R-HSA-5693568;Reactome: R-HSA-6783310 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway" XP_046740887.1 6 MetaCyc: PWY-6749;KEGG: 00520+5.4.2.3;Reactome: R-HSA-446210;KEGG: 00520+5.4.2.10;MetaCyc: PWY-6906;MetaCyc: PWY-5514 "CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"Amino sugar and nucleotide sugar metabolism";"Chitin derivatives degradation";"UDP-N-acetyl-D-galactosamine biosynthesis II" XP_046753336.1 1 Reactome: R-HSA-6811436 "COPI-independent Golgi-to-ER retrograde traffic" XP_046735534.1 3 KEGG: 00230+2.7.6.1;Reactome: R-HSA-73843;KEGG: 00030+2.7.6.1 "Purine metabolism";"5-Phosphoribose 1-diphosphate biosynthesis";"Pentose phosphate pathway" XP_046748603.1 3 Reactome: R-HSA-8957275;Reactome: R-HSA-114608;Reactome: R-HSA-381426 "Post-translational protein phosphorylation";"Platelet degranulation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" XP_046741403.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046746665.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046748388.1 27 Reactome: R-HSA-168276;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-168271;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-159230;Reactome: R-HSA-1169408;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749 "NS1 Mediated Effects on Host Pathways";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Late Events";"SUMOylation of DNA replication proteins";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs" XP_046752712.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046745074.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" XP_046740139.1 7 Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-76061 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" XP_046747650.1 3 Reactome: R-HSA-4724325;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.265 "Defective ALG8 causes ALG8-CDG (CDG-1h)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis" XP_046742946.1 2 Reactome: R-HSA-1268020;Reactome: R-HSA-8949664 "Mitochondrial protein import";"Processing of SMDT1" XP_046744277.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046737655.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046744541.1 6 KEGG: 00190+7.1.2.2;Reactome: R-HSA-1268020;KEGG: 00195+7.1.2.2;Reactome: R-HSA-8949613;MetaCyc: PWY-7980;Reactome: R-HSA-163210 "Oxidative phosphorylation";"Mitochondrial protein import";"Photosynthesis";"Cristae formation";"ATP biosynthesis";"Formation of ATP by chemiosmotic coupling" XP_046747900.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046739924.1 5 Reactome: R-HSA-1266695;Reactome: R-HSA-3214858;Reactome: R-HSA-3247509;Reactome: R-HSA-201722;Reactome: R-HSA-8939243 "Interleukin-7 signaling";"RMTs methylate histone arginines";"Chromatin modifying enzymes";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046748477.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046744336.1 12 Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690 "EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events" XP_046734698.1 1 Reactome: R-HSA-977347 "Serine biosynthesis" XP_046735054.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046742134.1 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" XP_046737255.1 11 Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096;Reactome: R-HSA-3928665;Reactome: R-HSA-2894862;Reactome: R-HSA-205043;Reactome: R-HSA-2122948;Reactome: R-HSA-9017802;Reactome: R-HSA-193692;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NRIF signals cell death from the nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Regulated proteolysis of p75NTR";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus" XP_046736537.1 7 Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes" XP_046748262.1 3 Reactome: R-HSA-392154;Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2 "Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction";"Purine metabolism" XP_046734910.1 2 Reactome: R-HSA-6807004;Reactome: R-HSA-877312 "Negative regulation of MET activity";"Regulation of IFNG signaling" XP_046753223.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046733818.1 12 Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-427413;Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-73980 "RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"NoRC negatively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination" XP_046750808.1 10 MetaCyc: PWY-3821;MetaCyc: PWY-7344;Reactome: R-HSA-5609977;MetaCyc: PWY-6317;Reactome: R-HSA-70370;MetaCyc: PWY-6397;MetaCyc: PWY-6527;KEGG: 00052+5.1.3.2;MetaCyc: PWY-7328;KEGG: 00520+5.1.3.2 "D-galactose detoxification";"UDP-alpha-D-galactose biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose degradation I (Leloir pathway)";"Galactose catabolism";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Stachyose degradation";"Galactose metabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Amino sugar and nucleotide sugar metabolism" XP_046743302.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046748809.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046744047.1 3 Reactome: R-HSA-8957275;Reactome: R-HSA-381038;Reactome: R-HSA-381426 "Post-translational protein phosphorylation";"XBP1(S) activates chaperone genes";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" XP_046737021.1 4 Reactome: R-HSA-1614603;KEGG: 00270+4.2.1.22;KEGG: 00260+4.2.1.22;MetaCyc: PWY-801 "Cysteine formation from homocysteine";"Cysteine and methionine metabolism";"Glycine, serine and threonine metabolism";"Homocysteine and cysteine interconversion" XP_046747403.1 5 Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288 "Transferrin endocytosis and recycling";"Ion channel transport";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1" XP_046747922.1 26 Reactome: R-HSA-1234158;Reactome: R-HSA-3899300;Reactome: R-HSA-1368082;Reactome: R-HSA-3214847;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-918233;Reactome: R-HSA-5621575;Reactome: R-HSA-2122947;Reactome: R-HSA-9614657;Reactome: R-HSA-9013695;Reactome: R-HSA-5617472;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-9013508;Reactome: R-HSA-1912408;Reactome: R-HSA-2644606;Reactome: R-HSA-201722;Reactome: R-HSA-2894862;Reactome: R-HSA-3371568;Reactome: R-HSA-8866907;Reactome: R-HSA-3134973;Reactome: R-HSA-8941856;Reactome: R-HSA-9617629;Reactome: R-HSA-933541;Reactome: R-HSA-210744 "Regulation of gene expression by Hypoxia-inducible Factor";"SUMOylation of transcription cofactors";"RORA activates gene expression";"HATs acetylate histones";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"TRAF3-dependent IRF activation pathway";"CD209 (DC-SIGN) signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"FOXO-mediated transcription of cell death genes";"NOTCH4 Intracellular Domain Regulates Transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PPARA activates gene expression";"Estrogen-dependent gene expression";"NOTCH3 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Formation of the beta-catenin:TCF transactivating complex";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Attenuation phase";"Activation of the TFAP2 (AP-2) family of transcription factors";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"RUNX3 regulates NOTCH signaling";"Regulation of FOXO transcriptional activity by acetylation";"TRAF6 mediated IRF7 activation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" XP_046746940.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046740441.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046749121.1 6 Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68962 "Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Orc1 removal from chromatin";"Activation of the pre-replicative complex" XP_046752994.1 10 Reactome: R-HSA-111464;Reactome: R-HSA-111463;Reactome: R-HSA-5628897;Reactome: R-HSA-2151201;Reactome: R-HSA-111459;Reactome: R-HSA-611105;Reactome: R-HSA-111458;Reactome: R-HSA-9627069;Reactome: R-HSA-3299685;Reactome: R-HSA-111457 "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"SMAC (DIABLO) binds to IAPs";"TP53 Regulates Metabolic Genes";"Transcriptional activation of mitochondrial biogenesis";"Activation of caspases through apoptosome-mediated cleavage";"Respiratory electron transport";"Formation of apoptosome";"Regulation of the apoptosome activity";"Detoxification of Reactive Oxygen Species";"Release of apoptotic factors from the mitochondria" XP_046740738.1 8 MetaCyc: PWY-7921;Reactome: R-HSA-5173105;MetaCyc: PWY-7922;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5083629 "Protein O-mannosylation I (yeast)";"O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2" XP_046736002.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046741150.1 3 Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" XP_046735884.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046744440.1 18 MetaCyc: PWY-7417;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8051;Reactome: R-HSA-1482801;Reactome: R-HSA-1482788;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482925;MetaCyc: PWY-7416;KEGG: 00592+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-6803;Reactome: R-HSA-1482922;MetaCyc: PWY-7783 "Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Synthesis of PA";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Anandamide biosynthesis I";"Acyl chain remodelling of PS";"Acyl chain remodelling of PC";"Arachidonic acid metabolism";"Acyl chain remodelling of PG";"Phospholipid remodeling (phosphatidylcholine, yeast)";"alpha-Linolenic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PI";"Plasmalogen degradation" XP_046753522.1 2 Reactome: R-HSA-877300;Reactome: R-HSA-2132295 "Interferon gamma signaling";"MHC class II antigen presentation" XP_046741963.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046748434.1 3 Reactome: R-HSA-5083627;Reactome: R-HSA-2022854;Reactome: R-HSA-5173105 "Defective LARGE causes MDDGA6 and MDDGB6";"Keratan sulfate biosynthesis";"O-linked glycosylation" XP_046741615.1 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" XP_046736466.1 13 Reactome: R-HSA-416572;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;Reactome: R-HSA-3928663;KEGG: 04151+2.7.11.1;Reactome: R-HSA-3928662;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5627117;KEGG: 04150+2.7.11.1 "Sema4D induced cell migration and growth-cone collapse";"Relaxin signaling pathway";"Human papillomavirus infection";"VEGFA-VEGFR2 Pathway";"Human cytomegalovirus infection";"Thermogenesis";"G alpha (12/13) signalling events";"EPHA-mediated growth cone collapse";"PI3K-Akt signaling pathway";"EPHB-mediated forward signaling";"Human immunodeficiency virus 1 infection";"RHO GTPases Activate ROCKs";"mTOR signaling pathway" XP_046741602.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046734714.1 56 Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-5676590;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-69601;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-983168;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-75815;Reactome: R-HSA-5358346;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-5689603;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-1236974;Reactome: R-HSA-5689880;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-9010553;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-450408;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257 "CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"NIK-->noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Downstream TCR signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog ligand biogenesis";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"UCH proteinases";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"ER-Phagosome pathway";"Ub-specific processing proteases";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of expression of SLITs and ROBOs";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Degradation of AXIN" XP_046753007.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046739922.1 5 Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-3247509;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"Chromatin modifying enzymes";"RMTs methylate histone arginines";"Interleukin-7 signaling" XP_046750394.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046735885.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046733960.1 15 Reactome: R-HSA-167246;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-9603505;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-167238;Reactome: R-HSA-167152 "Tat-mediated elongation of the HIV-1 transcript";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"NTRK3 as a dependence receptor";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat" XP_046752155.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-8873719 "RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation" XP_046736315.1 4 Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-112308;Reactome: R-HSA-5576893 "NCAM1 interactions";"Phase 0 - rapid depolarisation";"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase" XP_046744698.1 1 Reactome: R-HSA-4615885 "SUMOylation of DNA replication proteins" XP_046745359.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046733928.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046751656.1 56 Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-1236974;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827 "GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"ER-Phagosome pathway";"Regulation of RUNX3 expression and activity";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex" XP_046748729.1 3 Reactome: R-HSA-3108214;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394 "SUMOylation of DNA damage response and repair proteins";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER" XP_046751388.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046742615.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046751243.1 6 MetaCyc: PWY-5686;MetaCyc: PWY-7790;Reactome: R-HSA-500753;KEGG: 00983+2.4.2.10;KEGG: 00240+2.4.2.10;MetaCyc: PWY-7791 "UMP biosynthesis I";"UMP biosynthesis II";"Pyrimidine biosynthesis";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"UMP biosynthesis III" XP_046734190.1 8 KEGG: 00620+1.1.1.27;Reactome: R-HSA-70268;KEGG: 00010+1.1.1.27;KEGG: 00640+1.1.1.27;MetaCyc: PWY-8086;MetaCyc: PWY-5481;KEGG: 00270+1.1.1.27;MetaCyc: PWY-6901 "Pyruvate metabolism";"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Propanoate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate fermentation to (S)-lactate";"Cysteine and methionine metabolism";"Superpathway of glucose and xylose degradation" XP_046737360.1 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" XP_046734269.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046738860.1 2 Reactome: R-HSA-110320;Reactome: R-HSA-5689880 "Translesion Synthesis by POLH";"Ub-specific processing proteases" XP_046750480.1 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" XP_046735882.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046743509.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046738752.1 5 KEGG: 00515+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922 "Mannose type O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)" XP_046733805.1 1 Reactome: R-HSA-5689877 "Josephin domain DUBs" XP_046746046.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046750085.1 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" XP_046739070.1 9 MetaCyc: PWY-7117;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5743;MetaCyc: PWY-6142;MetaCyc: PWY-5744;MetaCyc: PWY-7115;MetaCyc: PWY-5789;MetaCyc: PWY-241 "C4 photosynthetic carbon assimilation cycle, PEPCK type";"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"3-hydroxypropanoate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type" XP_046742911.1 2 Reactome: R-HSA-2142691;Reactome: R-HSA-2142700 "Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)" XP_046753247.1 6 MetaCyc: PWY-6854;Reactome: R-HSA-8950505;Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;Reactome: R-HSA-2151201;Reactome: R-HSA-8862803 "Ethylene biosynthesis III (microbes)";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Transcriptional activation of mitochondrial biogenesis";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" XP_046744519.1 1 Reactome: R-HSA-5601884 "PIWI-interacting RNA (piRNA) biogenesis" XP_046752331.1 3 KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway" XP_046738785.1 3 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6811440 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network" XP_046747084.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046753393.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046753327.1 7 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046746296.1 2 Reactome: R-HSA-390471;Reactome: R-HSA-6791226 "Association of TriC/CCT with target proteins during biosynthesis";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046747438.1 8 KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;MetaCyc: PWY-7980 "Photosynthesis";"Oxidative phosphorylation";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Ion channel transport";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"ATP biosynthesis" XP_046738016.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046747685.1 6 MetaCyc: PWY-7395;KEGG: 00052+3.5.1.25;Reactome: R-HSA-446210;MetaCyc: PWY-7077;KEGG: 00520+3.5.1.25;MetaCyc: PWY-6906 "D-galactosamine and N-acetyl-D-galactosamine degradation";"Galactose metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"N-acetyl-D-galactosamine degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin derivatives degradation" XP_046749225.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex" XP_046747452.1 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" XP_046745946.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046734045.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046735218.1 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" XP_046747043.1 1 Reactome: R-HSA-400253 "Circadian Clock" XP_046748355.1 2 Reactome: R-HSA-4641265;Reactome: R-HSA-5339700 "Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP" XP_046752765.1 2 Reactome: R-HSA-5632681;Reactome: R-HSA-5635838 "Ligand-receptor interactions";"Activation of SMO" XP_046750303.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046740246.1 5 Reactome: R-HSA-5625740;Reactome: R-HSA-5628897;Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-111447 "RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria" XP_046743339.1 5 KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661;MetaCyc: PWY-5084 "Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA" XP_046744413.1 3 Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-8876198 "Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"RAB GEFs exchange GTP for GDP on RABs" XP_046740707.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" XP_046737877.1 4 MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3 "Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Thiamine metabolism" XP_046741143.1 6 Reactome: R-HSA-189085;MetaCyc: PWY-622;MetaCyc: PWY-5067;MetaCyc: PWY-7900;KEGG: 00500+3.2.1.1;KEGG: 00500+2.4.1.18 "Digestion of dietary carbohydrate";"Starch biosynthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Starch and sucrose metabolism" XP_046736735.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046750060.1 5 Reactome: R-HSA-8866654;Reactome: R-HSA-201722;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-112382 "E3 ubiquitin ligases ubiquitinate target proteins";"Formation of the beta-catenin:TCF transactivating complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex" XP_046740207.1 2 Reactome: R-HSA-446205;KEGG: 00500+2.4.1.15 "Synthesis of GDP-mannose";"Starch and sucrose metabolism" XP_046753219.1 1 Reactome: R-HSA-211981 "Xenobiotics" XP_046746744.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046752973.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046752111.1 4 MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3 "Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Thiamine metabolism" XP_046738377.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046751186.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046753729.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046752431.1 1 Reactome: R-HSA-1614558 "Degradation of cysteine and homocysteine" XP_046735650.1 2 Reactome: R-HSA-418594;Reactome: R-HSA-375276 "G alpha (i) signalling events";"Peptide ligand-binding receptors" XP_046739839.1 4 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361;Reactome: R-HSA-5250958 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Neurexins and neuroligins";"Toxicity of botulinum toxin type B (BoNT/B)" XP_046752836.1 2 Reactome: R-HSA-877300;Reactome: R-HSA-2132295 "Interferon gamma signaling";"MHC class II antigen presentation" XP_046747623.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-5357905 "RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling" XP_046745604.1 6 Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" XP_046753958.1 4 Reactome: R-HSA-166058;Reactome: R-HSA-975138;Reactome: R-HSA-975871;Reactome: R-HSA-6799198 "MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"MyD88 cascade initiated on plasma membrane";"Complex I biogenesis" XP_046740898.1 1 Reactome: R-HSA-6793080 "rRNA modification in the mitochondrion" XP_046737395.1 2 Reactome: R-HSA-5250971;Reactome: R-HSA-5682910 "Toxicity of botulinum toxin type C (BoNT/C)";"LGI-ADAM interactions" XP_046753228.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046746939.1 29 Reactome: R-HSA-77075;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-112382;Reactome: R-HSA-167162;Reactome: R-HSA-73772;Reactome: R-HSA-167246;Reactome: R-HSA-76042;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-6782135;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-72086;Reactome: R-HSA-167161;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-73863;Reactome: R-HSA-5696400 "RNA Pol II CTD phosphorylation and interaction with CE";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Dual incision in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA Capping";"HIV Transcription Initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Termination";"Dual Incision in GG-NER" XP_046752996.1 10 Reactome: R-HSA-3299685;Reactome: R-HSA-111457;Reactome: R-HSA-9627069;Reactome: R-HSA-611105;Reactome: R-HSA-111458;Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-2151201;Reactome: R-HSA-5628897;Reactome: R-HSA-111459 "Detoxification of Reactive Oxygen Species";"Release of apoptotic factors from the mitochondria";"Regulation of the apoptosome activity";"Respiratory electron transport";"Formation of apoptosome";"SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Transcriptional activation of mitochondrial biogenesis";"TP53 Regulates Metabolic Genes";"Activation of caspases through apoptosome-mediated cleavage" XP_046736010.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046746248.1 4 Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823 "Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex" XP_046742564.1 12 Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-429947;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-166208;Reactome: R-HSA-72662;Reactome: R-HSA-1169408;Reactome: R-HSA-450408 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Deadenylation of mRNA";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"mTORC1-mediated signalling";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"ISG15 antiviral mechanism";"AUF1 (hnRNP D0) binds and destabilizes mRNA" XP_046740394.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046749990.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046739637.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-6798695 "Protein ubiquitination";"Neutrophil degranulation" XP_046743934.1 9 Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-6804756 "RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation" XP_046736800.1 10 KEGG: 00051+2.7.1.11;Reactome: R-HSA-70171;KEGG: 00010+2.7.1.11;KEGG: 00052+2.7.1.11;MetaCyc: PWY-7385;MetaCyc: PWY-1042;KEGG: 00680+2.7.1.11;MetaCyc: PWY-5484;KEGG: 00030+2.7.1.11;MetaCyc: PWY-1861 "Fructose and mannose metabolism";"Glycolysis";"Glycolysis / Gluconeogenesis";"Galactose metabolism";"1,3-propanediol biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)" XP_046737863.1 6 Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176187 "Switching of origins to a post-replicative state";"Unwinding of DNA";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress" XP_046745811.1 10 Reactome: R-HSA-442742;Reactome: R-HSA-437239;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-444257;KEGG: 04150+2.7.11.1 "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling";"Recycling pathway of L1";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"RSK activation";"mTOR signaling pathway" XP_046741715.1 3 KEGG: 00970+6.1.1.5;Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" XP_046739993.1 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" XP_046736937.1 5 Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-6784531;Reactome: R-HSA-72187;Reactome: R-HSA-73856 "mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"tRNA processing in the nucleus";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination" XP_046737028.1 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" XP_046734232.1 2 MetaCyc: PWY-5386;KEGG: 00620+3.1.2.6 "Methylglyoxal degradation I";"Pyruvate metabolism" XP_046747941.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046745319.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046738783.1 3 Reactome: R-HSA-6811440;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Retrograde transport at the Trans-Golgi-Network";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046744642.1 2 Reactome: R-HSA-9033241;Reactome: R-HSA-389661 "Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation" XP_046747457.1 1 Reactome: R-HSA-111465 "Apoptotic cleavage of cellular proteins" XP_046743519.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046744739.1 6 KEGG: 00512+2.4.1.122;MetaCyc: PWY-7290;Reactome: R-HSA-5083632;KEGG: 00514+2.4.1.122;Reactome: R-HSA-913709;MetaCyc: PWY-7433 "Mucin type O-glycan biosynthesis";"Escherichia coli serotype O86 O-antigen biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Other types of O-glycan biosynthesis";"O-linked glycosylation of mucins";"Mucin core 1 and core 2 O-glycosylation" XP_046746837.1 4 MetaCyc: PWY-7494;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-3722;Reactome: R-HSA-6798163 "Choline degradation IV";"Glycine, serine and threonine metabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline catabolism" XP_046744475.1 4 MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23;MetaCyc: PWY-6483;Reactome: R-HSA-1660662 "Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism";"Ceramide degradation (generic)";"Glycosphingolipid metabolism" XP_046748019.1 7 Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-73980 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination" XP_046748312.1 7 Reactome: R-HSA-156711;Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-1538133;Reactome: R-HSA-1362300;Reactome: R-HSA-69656 "Polo-like kinase mediated events";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"G0 and Early G1";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin A:Cdk2-associated events at S phase entry" XP_046741685.1 3 MetaCyc: PWY-7800;MetaCyc: PWY-7799;Reactome: R-HSA-2514859 "Ac/N-end rule pathway";"Arg/N-end rule pathway (eukaryotic)";"Inactivation, recovery and regulation of the phototransduction cascade" XP_046736022.1 1 Reactome: R-HSA-202733 "Cell surface interactions at the vascular wall" XP_046738401.1 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" XP_046736274.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046741176.1 2 Reactome: R-HSA-382556;Reactome: R-HSA-5678895 "ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis" XP_046751611.1 8 MetaCyc: PWY-7524;KEGG: 00900+1.1.1.34;Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;MetaCyc: PWY-6174;MetaCyc: PWY-922;Reactome: R-HSA-191273;MetaCyc: PWY-7391 "Mevalonate pathway III (archaea)";"Terpenoid backbone biosynthesis";"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"Mevalonate pathway II (archaea)";"Mevalonate pathway I";"Cholesterol biosynthesis";"Isoprene biosynthesis II (engineered)" XP_046747277.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046743001.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046734051.1 9 Reactome: R-HSA-3560783;Reactome: R-HSA-2024096;Reactome: R-HSA-3656253;Reactome: R-HSA-3560801;Reactome: R-HSA-3656237;Reactome: R-HSA-975634;Reactome: R-HSA-1971475;Reactome: R-HSA-2022928;Reactome: R-HSA-4420332 "Defective B4GALT7 causes EDS, progeroid type";"HS-GAG degradation";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective B3GAT3 causes JDSSDHD";"Defective EXT2 causes exostoses 2";"Retinoid metabolism and transport";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG biosynthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1" XP_046750465.1 1 Reactome: R-HSA-8953750 "Transcriptional Regulation by E2F6" XP_046747428.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046743605.1 3 KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3 "Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis" XP_046750789.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046746379.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection" XP_046745081.1 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046752690.1 2 Reactome: R-HSA-6804758;Reactome: R-HSA-3214847 "Regulation of TP53 Activity through Acetylation";"HATs acetylate histones" XP_046745758.1 17 Reactome: R-HSA-6782210;Reactome: R-HSA-5358606;Reactome: R-HSA-174437;Reactome: R-HSA-5696397;Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-69183;Reactome: R-HSA-174414;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-174417;Reactome: R-HSA-6782135;Reactome: R-HSA-5358565;Reactome: R-HSA-5656169;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-69166 "Gap-filling DNA repair synthesis and ligation in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Removal of the Flap Intermediate from the C-strand";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Dual Incision in GG-NER";"Polymerase switching";"Processive synthesis on the lagging strand";"Processive synthesis on the C-strand of the telomere";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Telomere C-strand (Lagging Strand) Synthesis";"Dual incision in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Termination of translesion DNA synthesis";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate" XP_046744100.1 9 MetaCyc: PWY-7385;MetaCyc: PWY-7902;MetaCyc: PWY-6118;MetaCyc: PWY-5667;KEGG: 00564+1.1.1.8;MetaCyc: PWY-5981;MetaCyc: PWY-7411;KEGG: 00564+1.1.1.94;Reactome: R-HSA-1483166 "1,3-propanediol biosynthesis (engineered)";"Glucosylglycerol biosynthesis";"Glycerol-3-phosphate shuttle";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Glycerophospholipid metabolism";"Synthesis of PA" XP_046746668.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046751908.1 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" XP_046742875.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046746820.1 2 Reactome: R-HSA-6807878;Reactome: R-HSA-6811434 "COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046738419.1 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" XP_046749757.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046741481.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046740852.1 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" XP_046743067.1 4 Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-5625970;Reactome: R-HSA-2132295 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate KTN1";"MHC class II antigen presentation" XP_046749028.1 13 MetaCyc: PWY-7384;MetaCyc: PWY-5913;KEGG: 00020+4.2.1.2;MetaCyc: PWY-561;MetaCyc: PWY-5392;MetaCyc: PWY-5690;MetaCyc: PWY-8086;Reactome: R-HSA-71403;MetaCyc: PWY-6969;MetaCyc: PWY-7254;KEGG: 00720+4.2.1.2;MetaCyc: PWY-6728;KEGG: 00620+4.2.1.2 "Anaerobic energy metabolism (invertebrates, mitochondrial)";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Citric acid cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle VII (acetate-producers)";"Carbon fixation pathways in prokaryotes";"Methylaspartate cycle";"Pyruvate metabolism" XP_046746756.1 9 Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-113501;Reactome: R-HSA-174430;Reactome: R-HSA-69091;Reactome: R-HSA-69205;Reactome: R-HSA-69183;Reactome: R-HSA-68952;Reactome: R-HSA-69166 "Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Telomere C-strand synthesis initiation";"Polymerase switching";"G1/S-Specific Transcription";"Processive synthesis on the lagging strand";"DNA replication initiation";"Removal of the Flap Intermediate" XP_046752536.1 1 KEGG: 00970+6.1.1.2 "Aminoacyl-tRNA biosynthesis" XP_046739050.1 5 Reactome: R-HSA-2206305;KEGG: 00531+3.1.6.14;Reactome: R-HSA-2022857;Reactome: R-HSA-432720;Reactome: R-HSA-6798695 "MPS IIID - Sanfilippo syndrome D";"Glycosaminoglycan degradation";"Keratan sulfate degradation";"Lysosome Vesicle Biogenesis";"Neutrophil degranulation" XP_046739529.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046748860.1 2 Reactome: R-HSA-6783310;Reactome: R-HSA-5693568 "Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates" XP_046749905.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046744345.1 12 Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878 "Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport" XP_046742393.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046739595.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046736724.1 1 Reactome: R-HSA-112308 "Presynaptic depolarization and calcium channel opening" XP_046745260.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046736605.1 15 MetaCyc: PWY-7218;MetaCyc: PWY-7383;MetaCyc: PWY-7003;Reactome: R-HSA-70171;MetaCyc: PWY-8004;MetaCyc: PWY-5723;KEGG: 00620+2.7.1.40;KEGG: 00230+2.7.1.40;MetaCyc: PWY-1042;MetaCyc: PWY-5484;KEGG: 00010+2.7.1.40;MetaCyc: PWY-2221;MetaCyc: PWY-6142;MetaCyc: PWY-6901;MetaCyc: PWY-6886 "Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycerol degradation to butanol";"Glycolysis";"Entner-Doudoroff pathway I";"Rubisco shunt";"Pyruvate metabolism";"Purine metabolism";"Glycolysis IV (plant cytosol)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Superpathway of glucose and xylose degradation";"1-butanol autotrophic biosynthesis (engineered)" XP_046735203.1 14 KEGG: 00010+4.2.1.11;MetaCyc: PWY-7124;MetaCyc: PWY-6886;MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-6901;MetaCyc: PWY-6142;MetaCyc: PWY-2221;MetaCyc: PWY-1622;KEGG: 00680+4.2.1.11;MetaCyc: PWY-7003;MetaCyc: PWY-7218;MetaCyc: PWY-8004;MetaCyc: PWY-5723 "Glycolysis / Gluconeogenesis";"Ethylene biosynthesis V (engineered)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Glycerol degradation to butanol";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Entner-Doudoroff pathway I";"Rubisco shunt" XP_046739184.1 7 Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-69202 "G0 and Early G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"Cyclin E associated events during G1/S transition" XP_046748766.1 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" XP_046735814.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046744430.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046742900.1 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" XP_046742544.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046744044.1 6 Reactome: R-HSA-1855183;MetaCyc: PWY-6364;MetaCyc: PWY-6363;MetaCyc: PWY-6362;KEGG: 00562+3.1.3.56;KEGG: 04070+3.1.3.56 "Synthesis of IP2, IP, and Ins in the cytosol";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system" XP_046745905.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046743159.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046736291.1 7 MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5466;MetaCyc: PWY-7445;MetaCyc: PWY-7214;MetaCyc: PWY-6824;MetaCyc: PWY-5469 "Betanidin degradation";"Phenylpropanoid biosynthesis";"Matairesinol biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Justicidin B biosynthesis";"Sesamin biosynthesis" XP_046750488.1 3 Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13;Reactome: R-HSA-418597 "Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"G alpha (z) signalling events" XP_046749110.1 5 Reactome: R-HSA-4641257;Reactome: R-HSA-5545619;Reactome: R-HSA-201681;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880 "Degradation of AXIN";"XAV939 inhibits tankyrase, stabilizing AXIN";"TCF dependent signaling in response to WNT";"Regulation of PTEN stability and activity";"Ub-specific processing proteases" XP_046738368.1 2 Reactome: R-HSA-5578998;Reactome: R-HSA-174403 "Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)";"Glutathione synthesis and recycling" XP_046735656.1 4 Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3 "Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism" XP_046743829.1 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" XP_046749874.1 1 KEGG: 00480+3.4.11.1 "Glutathione metabolism" XP_046735890.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046741399.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884 "Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I" XP_046735285.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046748352.1 13 Reactome: R-HSA-8856825;Reactome: R-HSA-8866427;Reactome: R-HSA-177504;Reactome: R-HSA-416993;Reactome: R-HSA-437239;Reactome: R-HSA-167590;Reactome: R-HSA-8964038;Reactome: R-HSA-5140745;Reactome: R-HSA-5099900;Reactome: R-HSA-182218;Reactome: R-HSA-8856828;Reactome: R-HSA-3928665;Reactome: R-HSA-2132295 "Cargo recognition for clathrin-mediated endocytosis";"VLDLR internalisation and degradation";"Retrograde neurotrophin signalling";"Trafficking of GluR2-containing AMPA receptors";"Recycling pathway of L1";"Nef Mediated CD4 Down-regulation";"LDL clearance";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"WNT5A-dependent internalization of FZD4";"Nef Mediated CD8 Down-regulation";"Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"MHC class II antigen presentation" XP_046739536.1 18 MetaCyc: PWY-8086;MetaCyc: PWY-5690;MetaCyc: PWY-561;KEGG: 00680+1.1.1.37;Reactome: R-HSA-70263;KEGG: 00630+1.1.1.37;KEGG: 00270+1.1.1.37;KEGG: 00720+1.1.1.37;MetaCyc: PWY-6969;KEGG: 00020+1.1.1.37;MetaCyc: PWY-5392;MetaCyc: PWY-5913;KEGG: 00620+1.1.1.37;MetaCyc: PWY-7115;MetaCyc: PWY-7383;MetaCyc: PWY-6728;KEGG: 00710+1.1.1.37;MetaCyc: PWY-1622 "(S)-lactate fermentation to propanoate, acetate and hydrogen";"TCA cycle II (plants and fungi)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Methane metabolism";"Gluconeogenesis";"Glyoxylate and dicarboxylate metabolism";"Cysteine and methionine metabolism";"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citrate cycle (TCA cycle)";"Reductive TCA cycle II";"Partial TCA cycle (obligate autotrophs)";"Pyruvate metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Methylaspartate cycle";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation I (serine pathway)" XP_046740694.1 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" XP_046738624.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-936837 "Neutrophil degranulation";"Ion transport by P-type ATPases" XP_046745195.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097 "RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway" XP_046738201.1 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" XP_046750831.1 2 Reactome: R-HSA-8876725;Reactome: R-HSA-611105 "Protein methylation";"Respiratory electron transport" XP_046736857.1 2 Reactome: R-HSA-1169408;Reactome: R-HSA-168276 "ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways" XP_046740741.1 8 KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;Reactome: R-HSA-5173105;MetaCyc: PWY-7922;MetaCyc: PWY-7921;Reactome: R-HSA-5083629;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109 "Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis" XP_046736893.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046739018.1 3 KEGG: 00670+2.1.2.9;Reactome: R-HSA-5368286;KEGG: 00970+2.1.2.9 "One carbon pool by folate";"Mitochondrial translation initiation";"Aminoacyl-tRNA biosynthesis" XP_046753812.1 5 Reactome: R-HSA-450321;Reactome: R-HSA-2871796;Reactome: R-HSA-2559580;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"FCERI mediated MAPK activation";"Oxidative Stress Induced Senescence";"mTOR signaling pathway";"Activation of the AP-1 family of transcription factors" XP_046752751.1 7 Reactome: R-HSA-3371453;Reactome: R-HSA-114608;Reactome: R-HSA-983170;Reactome: R-HSA-381042;Reactome: R-HSA-381070;Reactome: R-HSA-381183;Reactome: R-HSA-381033 "Regulation of HSF1-mediated heat shock response";"Platelet degranulation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"PERK regulates gene expression";"IRE1alpha activates chaperones";"ATF6 (ATF6-alpha) activates chaperone genes";"ATF6 (ATF6-alpha) activates chaperones" XP_046750178.1 4 Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553 "Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" XP_046751634.1 14 Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167242;Reactome: R-HSA-167200;Reactome: R-HSA-167287 "Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV elongation arrest and recovery" XP_046744785.1 7 Reactome: R-HSA-446205;KEGG: 00520+5.4.2.8;MetaCyc: PWY-5659;KEGG: 00051+5.4.2.8;MetaCyc: PWY-7456;MetaCyc: PWY-882;MetaCyc: PWY-7586 "Synthesis of GDP-mannose";"Amino sugar and nucleotide sugar metabolism";"GDP-mannose biosynthesis";"Fructose and mannose metabolism";"Beta-(1,4)-mannan degradation";"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation" XP_046739974.1 7 Reactome: R-HSA-5693565;Reactome: R-HSA-69473;MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-3108214;Reactome: R-HSA-5693571;Reactome: R-HSA-5693607 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"G2/M DNA damage checkpoint";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"SUMOylation of DNA damage response and repair proteins";"Nonhomologous End-Joining (NHEJ)";"Processing of DNA double-strand break ends" XP_046743902.1 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" XP_046751635.1 14 Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-167158;Reactome: R-HSA-167243 "Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery" XP_046744221.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046753296.1 5 Reactome: R-HSA-5689901;Reactome: R-HSA-5693565;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5693571 "Metalloprotease DUBs";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)" XP_046741014.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046750807.1 8 Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-381676;Reactome: R-HSA-983231;Reactome: R-HSA-163615;Reactome: R-HSA-442720;Reactome: R-HSA-432040;Reactome: R-HSA-180024 "PKA activation in glucagon signalling";"Hedgehog 'off' state";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Factors involved in megakaryocyte development and platelet production";"PKA activation";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Vasopressin regulates renal water homeostasis via Aquaporins";"DARPP-32 events" XP_046748506.1 3 Reactome: R-HSA-2024096;Reactome: R-HSA-2024101;Reactome: R-HSA-2206296 "HS-GAG degradation";"CS/DS degradation";"MPS II - Hunter syndrome" XP_046749368.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046747651.1 2 Reactome: R-HSA-195253;Reactome: R-HSA-5689896 "Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases" XP_046738486.1 2 KEGG: 00970+6.1.1.20;Reactome: R-HSA-379726 "Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" XP_046753863.1 4 Reactome: R-HSA-68884;Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-2132295 "Mitotic Telophase/Cytokinesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"MHC class II antigen presentation" XP_046745709.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046745542.1 1 Reactome: R-HSA-5389840 "Mitochondrial translation elongation" XP_046741707.1 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" XP_046738485.1 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.20 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046741644.1 13 Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane" XP_046749591.1 56 Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-75815;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-8939902;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-9010553;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-450408;Reactome: R-HSA-4641257 "NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Ubiquitin-dependent degradation of Cyclin D";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"UCH proteinases";"Hedgehog 'on' state";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX2 expression and activity";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"Regulation of expression of SLITs and ROBOs";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN" XP_046736751.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046747809.1 12 MetaCyc: PWY-5872;MetaCyc: PWY-5871;MetaCyc: PWY-6978;MetaCyc: PWY-5857;Reactome: R-HSA-1268020;KEGG: 00130+2.5.1.39;MetaCyc: PWY-5856;MetaCyc: PWY-5855;Reactome: R-HSA-2142789;MetaCyc: PWY-5870;MetaCyc: PWY-6708;MetaCyc: PWY-5873 "Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol-10 biosynthesis (prokaryotic)";"Mitochondrial protein import";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)" XP_046747350.1 2 Reactome: R-HSA-5689896;Reactome: R-HSA-195253 "Ovarian tumor domain proteases";"Degradation of beta-catenin by the destruction complex" XP_046750392.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046753490.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6784531 "Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus" XP_046741159.1 2 Reactome: R-HSA-6782315;MetaCyc: PWY-6829 "tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)" XP_046734986.1 13 MetaCyc: PWY-7220;MetaCyc: PWY-7226;KEGG: 00983+1.17.4.1;KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7222;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943 "Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Purine metabolism";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates" XP_046737679.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046734525.1 2 Reactome: R-HSA-6783984;Reactome: R-HSA-389661 "Glycine degradation";"Glyoxylate metabolism and glycine degradation" XP_046750288.1 3 Reactome: R-HSA-9639288;Reactome: R-HSA-70350;Reactome: R-HSA-168928 "Amino acids regulate mTORC1";"Fructose catabolism";"DDX58/IFIH1-mediated induction of interferon-alpha/beta" XP_046749548.1 13 Reactome: R-HSA-2160916;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883;MetaCyc: PWY-7822;KEGG: 00511+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662 "Hyaluronan uptake and degradation";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Chitin degradation III (Serratia)";"Other glycan degradation";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"Keratan sulfate degradation";"Glycosphingolipid metabolism" XP_046738838.1 4 KEGG: 00270+2.5.1.6;MetaCyc: PWY-5912;Reactome: R-HSA-156581;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"2'-deoxymugineic acid phytosiderophore biosynthesis";"Methylation";"S-adenosyl-L-methionine cycle II" XP_046743525.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046753378.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046751006.1 2 Reactome: R-HSA-2243919;Reactome: R-HSA-1566948 "Crosslinking of collagen fibrils";"Elastic fibre formation" XP_046745497.1 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" XP_046736579.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046751423.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046743444.1 1 Reactome: R-HSA-2022928 "HS-GAG biosynthesis" XP_046745522.1 4 KEGG: 00100+1.3.1.72;Reactome: R-HSA-6807062;MetaCyc: PWY-8026;Reactome: R-HSA-6807047 "Steroid biosynthesis";"Cholesterol biosynthesis via lathosterol";"Sterol biosynthesis (methylotrophs)";"Cholesterol biosynthesis via desmosterol" XP_046738751.1 5 KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922 "Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)" XP_046751982.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046737241.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046748292.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046752316.1 13 Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" XP_046746295.1 3 Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648 "Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK" XP_046743892.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046738627.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-936837 "Neutrophil degranulation";"Ion transport by P-type ATPases" XP_046742616.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046747975.1 5 Reactome: R-HSA-4755579;Reactome: R-HSA-193048;MetaCyc: PWY-6129;KEGG: 00510+1.3.1.94;Reactome: R-HSA-446199 "Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ";"Androgen biosynthesis";"Dolichol and dolichyl phosphate biosynthesis";"N-Glycan biosynthesis";"Synthesis of Dolichyl-phosphate" XP_046734755.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" XP_046745538.1 4 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-1268020 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial protein import" XP_046735629.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046739877.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046741336.1 10 Reactome: R-HSA-8936459;Reactome: R-HSA-3899300;Reactome: R-HSA-9022699;Reactome: R-HSA-9022538;Reactome: R-HSA-9022702;Reactome: R-HSA-400206;Reactome: R-HSA-9615017;Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-9022692 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of transcription cofactors";"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates transcription of neuronal ligands";"Regulation of lipid metabolism by PPARalpha";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"Regulation of MECP2 expression and activity" XP_046752924.1 3 Reactome: R-HSA-73621;Reactome: R-HSA-196807;Reactome: R-HSA-74259 "Pyrimidine catabolism";"Nicotinate metabolism";"Purine catabolism" XP_046736196.1 1 Reactome: R-HSA-419771 "Opsins" XP_046753227.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046737401.1 56 Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-4641258;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-450408;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880 "ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"UCH proteinases";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Degradation of DVL";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of AXIN";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases" XP_046735942.1 57 Reactome: R-HSA-5607761;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-180585;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-6798695;Reactome: R-HSA-174113 "Dectin-1 mediated noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Vif-mediated degradation of APOBEC3G";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"UCH proteinases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Neutrophil degranulation";"SCF-beta-TrCP mediated degradation of Emi1" XP_046737664.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046753965.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046734169.1 1 Reactome: R-HSA-5689603 "UCH proteinases" XP_046748180.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046747796.1 1 Reactome: R-HSA-2514859 "Inactivation, recovery and regulation of the phototransduction cascade" XP_046747027.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046753193.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046734061.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046743011.1 1 Reactome: R-HSA-5676934 "Protein repair" XP_046741475.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046735649.1 2 Reactome: R-HSA-375276;Reactome: R-HSA-418594 "Peptide ligand-binding receptors";"G alpha (i) signalling events" XP_046750793.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046736468.1 13 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-4420097;Reactome: R-HSA-416572;Reactome: R-HSA-416482;Reactome: R-HSA-3928663;Reactome: R-HSA-3928662;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5627117;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"VEGFA-VEGFR2 Pathway";"Sema4D induced cell migration and growth-cone collapse";"G alpha (12/13) signalling events";"EPHA-mediated growth cone collapse";"EPHB-mediated forward signaling";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"RHO GTPases Activate ROCKs";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046740650.1 2 Reactome: R-HSA-418594;Reactome: R-HSA-6814122 "G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" XP_046745659.1 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" XP_046752284.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046746076.1 1 Reactome: R-HSA-1483101 "Synthesis of PS" XP_046749292.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046747852.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046754005.1 3 KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961;Reactome: R-HSA-196783 "Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis" XP_046737747.1 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046734937.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046740716.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046750404.1 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" XP_046752013.1 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" XP_046751225.1 5 Reactome: R-HSA-1989781;Reactome: R-HSA-380994;Reactome: R-HSA-2426168;Reactome: R-HSA-9614657;Reactome: R-HSA-381183 "PPARA activates gene expression";"ATF4 activates genes in response to endoplasmic reticulum stress";"Activation of gene expression by SREBF (SREBP)";"FOXO-mediated transcription of cell death genes";"ATF6 (ATF6-alpha) activates chaperone genes" XP_046738820.1 6 Reactome: R-HSA-2173788;Reactome: R-HSA-8863795;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-8948751 "Downregulation of TGF-beta receptor signaling";"Downregulation of ERBB2 signaling";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Regulation of PTEN stability and activity" XP_046735970.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046738062.1 2 Reactome: R-HSA-3359473;Reactome: R-HSA-196741 "Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD";"Cobalamin (Cbl, vitamin B12) transport and metabolism" XP_046753684.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046743161.1 1 KEGG: 00970+6.1.1.22 "Aminoacyl-tRNA biosynthesis" XP_046751643.1 1 Reactome: R-HSA-8851805 "MET activates RAS signaling" XP_046744428.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046743070.1 4 Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "MHC class II antigen presentation";"RHO GTPases activate KTN1";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046749418.1 5 MetaCyc: PWY-7426;KEGG: 00510+2.4.1.68;KEGG: 00533+2.4.1.68;KEGG: 00513+2.4.1.68;Reactome: R-HSA-975578 "Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Glycosaminoglycan biosynthesis - keratan sulfate";"Various types of N-glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway" XP_046742002.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-6798695 "Neddylation";"Neutrophil degranulation" XP_046733878.1 6 KEGG: 00562+3.1.3.66;Reactome: R-HSA-1855183;Reactome: R-HSA-1660516;MetaCyc: PWY-6368;KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499 "Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the early endosome membrane";"3-phosphoinositide degradation";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane" XP_046734808.1 2 Reactome: R-HSA-74217;KEGG: 00230+1.7.1.7 "Purine salvage";"Purine metabolism" XP_046746741.1 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" XP_046736995.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046741956.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046740584.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046744105.1 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" XP_046734769.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046746891.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046737353.1 4 Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664 "Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation" XP_046735726.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046748480.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046754098.1 2 Reactome: R-HSA-5620924;Reactome: R-HSA-5610787 "Intraflagellar transport";"Hedgehog 'off' state" XP_046735558.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046745777.1 60 MetaCyc: PWY-7007;MetaCyc: PWY-7606;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-7654;MetaCyc: PWY-7779;Reactome: R-HSA-77310;MetaCyc: PWY-6583;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00410+4.2.1.17;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00650+4.2.1.17;Reactome: R-HSA-77346;Reactome: R-HSA-77285;KEGG: 00071+4.2.1.17+1.1.1.211;MetaCyc: PWY-5138;KEGG: 00362+4.2.1.17;MetaCyc: PWY-6944;KEGG: 00281+4.2.1.17;MetaCyc: PWY-7094;Reactome: R-HSA-77348;KEGG: 00623+1.1.1.35;Reactome: R-HSA-77288;KEGG: 00380+4.2.1.17;MetaCyc: PWY-7216;MetaCyc: PWY-5789;MetaCyc: PWY-1361;MetaCyc: PWY-7726;MetaCyc: PWY-6883;MetaCyc: PWY-7401;Reactome: R-HSA-1482798;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00720+4.2.1.17;KEGG: 00310+4.2.1.17;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;KEGG: 00903+4.2.1.17;KEGG: 00640+4.2.1.17;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;MetaCyc: PWY-5136;KEGG: 00360+4.2.1.17;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;Reactome: R-HSA-77305;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;Reactome: R-HSA-77350;MetaCyc: PWY-6863;KEGG: 00627+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6945;KEGG: 00280+4.2.1.17;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-5109;KEGG: 00062+4.2.1.17+1.1.1.211;KEGG: 00592+4.2.1.17;KEGG: 00930+4.2.1.17 "Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Butanoate metabolism";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Methyl tert-butyl ether degradation";"Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA";"Pyruvate fermentation to butanol I";"Valine, leucine and isoleucine degradation";"beta-Alanine metabolism";"Fatty acid elongation";"Butanoate metabolism";"Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA";"Beta oxidation of myristoyl-CoA to lauroyl-CoA";"Fatty acid degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Benzoate degradation";"Androstenedione degradation";"Geraniol degradation";"Fatty acid salvage";"Beta oxidation of octanoyl-CoA to hexanoyl-CoA";"Toluene degradation";"mitochondrial fatty acid beta-oxidation of unsaturated fatty acids";"Tryptophan metabolism";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Benzoyl-coa degradation I (aerobic)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Pyruvate fermentation to butanol II (engineered)";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Acyl chain remodeling of CL";"Geraniol degradation";"Carbon fixation pathways in prokaryotes";"Lysine degradation";"Benzoate degradation";"Glutaryl-coa degradation";"Limonene and pinene degradation";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Tryptophan metabolism";"Spodoptera littoralis pheromone biosynthesis";"Fatty acid beta-oxidation II (plant peroxisome)";"Phenylalanine metabolism";"Lysine degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Beta oxidation of palmitoyl-CoA to myristoyl-CoA";"Fatty acid degradation";"2-methylpropene degradation";"Beta oxidation of hexanoyl-CoA to butanoyl-CoA";"Pyruvate fermentation to hexanol (engineered)";"Aminobenzoate degradation";"Butanoate metabolism";"Caprolactam degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Valine, leucine and isoleucine degradation";"Fatty acid degradation";"Fermentation to 2-methylbutanoate";"Fatty acid elongation";"alpha-Linolenic acid metabolism";"Caprolactam degradation" XP_046753708.1 4 KEGG: 00983+6.3.5.2;MetaCyc: PWY-7221;KEGG: 00230+6.3.5.2;Reactome: R-HSA-73817 "Drug metabolism - other enzymes";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis" XP_046735535.1 3 KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1;Reactome: R-HSA-73843 "Purine metabolism";"Pentose phosphate pathway";"5-Phosphoribose 1-diphosphate biosynthesis" XP_046739997.1 7 Reactome: R-HSA-73817;MetaCyc: PWY-6121;MetaCyc: PWY-7282;MetaCyc: PWY-6122;KEGG: 00250+2.4.2.14;KEGG: 00230+2.4.2.14;MetaCyc: PWY-6277 "Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Alanine, aspartate and glutamate metabolism";"Purine metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis" XP_046746454.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046735613.1 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" XP_046741121.1 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" XP_046734676.1 3 Reactome: R-HSA-9033241;Reactome: R-HSA-9603798;Reactome: R-HSA-8866654 "Peroxisomal protein import";"Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046751834.1 2 Reactome: R-HSA-8873719;Reactome: R-HSA-6803205 "RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" XP_046737815.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046747803.1 8 Reactome: R-HSA-3928665;Reactome: R-HSA-8856828;Reactome: R-HSA-5099900;Reactome: R-HSA-196025;Reactome: R-HSA-190873;Reactome: R-HSA-432720;Reactome: R-HSA-8856825;Reactome: R-HSA-5140745 "EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD4";"Formation of annular gap junctions";"Gap junction degradation";"Lysosome Vesicle Biogenesis";"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2" XP_046741938.1 1 Reactome: R-HSA-191859 "snRNP Assembly" XP_046738895.1 14 Reactome: R-HSA-6807878;Reactome: R-HSA-1632852;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-5620924;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399 "COPI-mediated anterograde transport";"Macroautophagy";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"Intraflagellar transport";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy" XP_046747659.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046735838.1 2 Reactome: R-HSA-114608;KEGG: 00970+6.1.1.3 "Platelet degranulation";"Aminoacyl-tRNA biosynthesis" XP_046736275.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046745064.1 2 Reactome: R-HSA-8949215;Reactome: R-HSA-8949664 "Mitochondrial calcium ion transport";"Processing of SMDT1" XP_046749120.1 6 Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68949 "Activation of ATR in response to replication stress";"Unwinding of DNA";"Assembly of the pre-replicative complex";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Orc1 removal from chromatin" XP_046741489.1 12 Reactome: R-HSA-5362798;Reactome: R-HSA-1442490;Reactome: R-HSA-75893;Reactome: R-HSA-2644606;Reactome: R-HSA-2660826;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-177929;Reactome: R-HSA-193692;Reactome: R-HSA-982772;Reactome: R-HSA-1251985 "Release of Hh-Np from the secreting cell";"Collagen degradation";"TNF signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Signaling by EGFR";"Regulated proteolysis of p75NTR";"Growth hormone receptor signaling";"Nuclear signaling by ERBB4" XP_046739266.1 6 Reactome: R-HSA-73817;MetaCyc: PWY-7234;MetaCyc: PWY-6123;KEGG: 00670+2.1.2.3;KEGG: 00230+3.5.4.10+2.1.2.3;MetaCyc: PWY-6124 "Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis I";"One carbon pool by folate";"Purine metabolism";"Inosine-5'-phosphate biosynthesis II" XP_046753032.1 16 Reactome: R-HSA-2219530;Reactome: R-HSA-8847993;Reactome: R-HSA-1963640;Reactome: R-HSA-1963642;Reactome: R-HSA-1257604;Reactome: R-HSA-1236394;Reactome: R-HSA-1251985;Reactome: R-HSA-6785631;Reactome: R-HSA-8863795;Reactome: R-HSA-1250196;Reactome: R-HSA-1250347;Reactome: R-HSA-1250342;Reactome: R-HSA-1227986;Reactome: R-HSA-5673001;Reactome: R-HSA-6811558;Reactome: R-HSA-9664565 "Constitutive Signaling by Aberrant PI3K in Cancer";"ERBB2 Activates PTK6 Signaling";"GRB2 events in ERBB2 signaling";"PI3K events in ERBB2 signaling";"PIP3 activates AKT signaling";"Signaling by ERBB4";"Nuclear signaling by ERBB4";"ERBB2 Regulates Cell Motility";"Downregulation of ERBB2 signaling";"SHC1 events in ERBB2 signaling";"SHC1 events in ERBB4 signaling";"PI3K events in ERBB4 signaling";"Signaling by ERBB2";"RAF/MAP kinase cascade";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Signaling by ERBB2 KD Mutants" XP_046746715.1 1 Reactome: R-HSA-197264 "Nicotinamide salvaging" XP_046751804.1 2 Reactome: R-HSA-400253;Reactome: R-HSA-2151201 "Circadian Clock";"Transcriptional activation of mitochondrial biogenesis" XP_046744478.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046736158.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046750495.1 22 Reactome: R-HSA-5358751;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-5467348;Reactome: R-HSA-196299;Reactome: R-HSA-6811558;Reactome: R-HSA-68877;Reactome: R-HSA-432142;Reactome: R-HSA-5663220;Reactome: R-HSA-5358749;Reactome: R-HSA-2500257;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-4641262;Reactome: R-HSA-5358752;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-5467337;Reactome: R-HSA-2467813;Reactome: R-HSA-5358747;Reactome: R-HSA-9648025;Reactome: R-HSA-5673000 "S45 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"Truncations of AMER1 destabilize the destruction complex";"Beta-catenin phosphorylation cascade";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Mitotic Prometaphase";"Platelet sensitization by LDL";"RHO GTPases Activate Formins";"S37 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"T41 mutants of beta-catenin aren't phosphorylated";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"APC truncation mutants have impaired AXIN binding";"Separation of Sister Chromatids";"S33 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"RAF activation" XP_046738219.1 16 Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-167287;Reactome: R-HSA-8951664;Reactome: R-HSA-180585;Reactome: R-HSA-983168;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-1234176;Reactome: R-HSA-112382;Reactome: R-HSA-9010553;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-167243 "Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV elongation arrest and recovery";"Neddylation";"Vif-mediated degradation of APOBEC3G";"Antigen processing: Ubiquitination & Proteasome degradation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Formation of RNA Pol II elongation complex";"Regulation of expression of SLITs and ROBOs";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery" XP_046752508.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046751263.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046746218.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046741497.1 5 Reactome: R-HSA-6798695;KEGG: 00750+2.7.1.35;MetaCyc: PWY-7282;MetaCyc: PWY-7204;Reactome: R-HSA-964975 "Neutrophil degranulation";"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Pyridoxal 5'-phosphate salvage II (plants)";"Vitamins B6 activation to pyridoxal phosphate" XP_046740523.1 1 Reactome: R-HSA-1221632 "Meiotic synapsis" XP_046751479.1 4 Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-112382 "E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex" XP_046734629.1 4 Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046752092.1 13 MetaCyc: PWY-6545;MetaCyc: PWY-7220;MetaCyc: PWY-7226;KEGG: 00983+1.17.4.1;KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-7222;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7227 "Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Purine metabolism";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis" XP_046739593.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046751980.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046747600.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046748114.1 2 MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11 "L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis" XP_046752605.1 14 Reactome: R-HSA-8948700;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-426496;Reactome: R-HSA-5687128;Reactome: R-HSA-203927;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-426486;Reactome: R-HSA-9029569;Reactome: R-HSA-8934593;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408 "Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"Post-transcriptional silencing by small RNAs";"MAPK6/MAPK4 signaling";"MicroRNA (miRNA) biogenesis";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Small interfering RNA (siRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of RUNX1 Expression and Activity";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation" XP_046753917.1 1 Reactome: R-HSA-5223345 "Miscellaneous transport and binding events" XP_046733979.1 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" XP_046743781.1 1 Reactome: R-HSA-9617828 "FOXO-mediated transcription of cell cycle genes" XP_046741306.1 1 Reactome: R-HSA-2467813 "Separation of Sister Chromatids" XP_046735591.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046738209.1 2 KEGG: 00230+1.7.1.7;Reactome: R-HSA-74217 "Purine metabolism";"Purine salvage" XP_046741910.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046751988.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046748280.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046741304.1 1 Reactome: R-HSA-2467813 "Separation of Sister Chromatids" XP_046734289.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046753706.1 4 KEGG: 00983+6.3.5.2;KEGG: 00230+6.3.5.2;MetaCyc: PWY-7221;Reactome: R-HSA-73817 "Drug metabolism - other enzymes";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis" XP_046743417.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046739588.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046750016.1 16 Reactome: R-HSA-176412;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-174048;Reactome: R-HSA-176409;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-176407;Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-8853884;Reactome: R-HSA-141430 "Phosphorylation of the APC/C";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex" XP_046749738.1 11 MetaCyc: PWY-8053;MetaCyc: PWY-8055;Reactome: R-HSA-2029485;MetaCyc: PWY-7782;KEGG: 00565+3.1.3.4;MetaCyc: PWY-6453;MetaCyc: PWY-8052;MetaCyc: PWY-8051;KEGG: 00561+3.1.3.4;KEGG: 00564+3.1.3.4;KEGG: 00600+3.1.3.4 "Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Role of phospholipids in phagocytosis";"Plasmalogen biosynthesis";"Ether lipid metabolism";"Stigma estolide biosynthesis";"2-arachidonoylglycerol biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Sphingolipid metabolism" XP_046743549.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046750736.1 7 Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation" XP_046750494.1 22 Reactome: R-HSA-196299;Reactome: R-HSA-6811558;Reactome: R-HSA-68877;Reactome: R-HSA-432142;Reactome: R-HSA-5663220;Reactome: R-HSA-5358749;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-5358747;Reactome: R-HSA-9648025;Reactome: R-HSA-5673000;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-5358752;Reactome: R-HSA-4641262;Reactome: R-HSA-2500257;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221 "Beta-catenin phosphorylation cascade";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Mitotic Prometaphase";"Platelet sensitization by LDL";"RHO GTPases Activate Formins";"S37 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"S33 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"RAF activation";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"T41 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Resolution of Sister Chromatid Cohesion";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway" XP_046747429.1 1 Reactome: R-HSA-1221632 "Meiotic synapsis" XP_046738496.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" XP_046743524.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046753368.1 9 Reactome: R-HSA-1475029;MetaCyc: PWY-7117;MetaCyc: PWY-5743;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5744;MetaCyc: PWY-6142;MetaCyc: PWY-241;MetaCyc: PWY-7115;MetaCyc: PWY-5789 "Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"3-hydroxypropanoate cycle";"Nitrogen metabolism";"Glyoxylate assimilation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle" XP_046738294.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" XP_046743452.1 10 Reactome: R-HSA-201722;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3214847;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5689880 "Formation of the beta-catenin:TCF transactivating complex";"mTOR signaling pathway";"HATs acetylate histones";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"Ub-specific processing proteases" XP_046750962.1 5 Reactome: R-HSA-73772;Reactome: R-HSA-427413;Reactome: R-HSA-73863;Reactome: R-HSA-73762;Reactome: R-HSA-5250924 "RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression" XP_046738345.1 23 Reactome: R-HSA-381676;Reactome: R-HSA-416476;Reactome: R-HSA-400042;Reactome: R-HSA-456926;Reactome: R-HSA-418555;Reactome: R-HSA-432040;Reactome: R-HSA-416482;Reactome: R-HSA-9009391;Reactome: R-HSA-418597;Reactome: R-HSA-418217;Reactome: R-HSA-392451;Reactome: R-HSA-8964616;Reactome: R-HSA-4086398;Reactome: R-HSA-8964315;Reactome: R-HSA-418592;Reactome: R-HSA-500657;Reactome: R-HSA-420092;Reactome: R-HSA-392851;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-428930;Reactome: R-HSA-6814122;Reactome: R-HSA-392170 "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G alpha (q) signalling events";"Adrenaline,noradrenaline inhibits insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (s) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (12/13) signalling events";"Extra-nuclear estrogen signaling";"G alpha (z) signalling events";"G beta:gamma signalling through PLC beta";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through CDC42";"Ca2+ pathway";"G beta:gamma signalling through BTK";"ADP signalling through P2Y purinoceptor 1";"Presynaptic function of Kainate receptors";"Glucagon-type ligand receptors";"Prostacyclin signalling through prostacyclin receptor";"G alpha (i) signalling events";"G-protein activation";"Thromboxane signalling through TP receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"ADP signalling through P2Y purinoceptor 12" XP_046743763.1 11 Reactome: R-HSA-114604;Reactome: R-HSA-432142;Reactome: R-HSA-391160;Reactome: R-HSA-210990;Reactome: R-HSA-909733;Reactome: R-HSA-388841;Reactome: R-HSA-912694;Reactome: R-HSA-877312;Reactome: R-HSA-512988;Reactome: R-HSA-389948;Reactome: R-HSA-9008059 "GPVI-mediated activation cascade";"Platelet sensitization by LDL";"Signal regulatory protein family interactions";"PECAM1 interactions";"Interferon alpha/beta signaling";"Costimulation by the CD28 family";"Regulation of IFNA signaling";"Regulation of IFNG signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"PD-1 signaling";"Interleukin-37 signaling" XP_046740966.1 3 Reactome: R-HSA-156590;Reactome: R-HSA-8963684;Reactome: R-HSA-204174 "Glutathione conjugation";"Tyrosine catabolism";"Regulation of pyruvate dehydrogenase (PDH) complex" XP_046737238.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046734537.1 2 MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21 "Mitochondrial L-carnitine shuttle";"Fatty acid degradation" XP_046740909.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046733760.1 2 Reactome: R-HSA-432720;Reactome: R-HSA-432722 "Lysosome Vesicle Biogenesis";"Golgi Associated Vesicle Biogenesis" XP_046742156.1 14 Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-7725;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-7035 "Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis" XP_046737656.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046745494.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046738078.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046752041.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046739719.1 31 MetaCyc: PWY-7858;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-2426168;MetaCyc: PWY-5147;Reactome: R-HSA-163765;MetaCyc: PWY-7723;MetaCyc: PWY-5994;MetaCyc: PWY-7746;MetaCyc: PWY-5366;Reactome: R-HSA-9029558;Reactome: R-HSA-199220;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWY-6799;MetaCyc: PWY-4381;MetaCyc: PWY-5973;MetaCyc: PWY-7388;MetaCyc: PWY-5367;MetaCyc: PWY-5966-1;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWYG-321;MetaCyc: PWY-5989;MetaCyc: PWY-6282;MetaCyc: PWY-5142;MetaCyc: PWY-8047;MetaCyc: PWY-6519;MetaCyc: PWY-6113;MetaCyc: PWY-7663;Reactome: R-HSA-75105;MetaCyc: PWY-5971;MetaCyc: PWY-7664 "(5Z)-dodecenoate biosynthesis II";"Biotin metabolism";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis I (plants)";"ChREBP activates metabolic gene expression";"Bacterial bioluminescence";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Mycobacterial sulfolipid biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Vitamin B5 (pantothenate) metabolism";"Mupirocin biosynthesis";"Pederin biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Cis-vaccenate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis";"";"Stearate biosynthesis II (bacteria and plants)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Bryostatin biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"Fatty acyl-CoA biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis IV (anaerobic)" XP_046737048.1 2 Reactome: R-HSA-3238698;Reactome: R-HSA-373080 "WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)" XP_046743093.1 1 Reactome: R-HSA-5693607 "Processing of DNA double-strand break ends" XP_046744064.1 4 Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange" XP_046747951.1 2 Reactome: R-HSA-3928665;Reactome: R-HSA-2682334 "EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling" XP_046739170.1 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" XP_046751960.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046741053.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046739392.1 12 Reactome: R-HSA-438066;Reactome: R-HSA-451308;Reactome: R-HSA-5673001;Reactome: R-HSA-9609736;KEGG: 00230+2.7.4.8;Reactome: R-HSA-8849932;Reactome: R-HSA-447038;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-9620244;MetaCyc: PWY-7221;Reactome: R-HSA-399719 "Unblocking of NMDA receptors, glutamate binding and activation";"Activation of Ca-permeable Kainate Receptor";"RAF/MAP kinase cascade";"Assembly and cell surface presentation of NMDA receptors";"Purine metabolism";"Synaptic adhesion-like molecules";"NrCAM interactions";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Long-term potentiation";"Guanosine ribonucleotides de novo biosynthesis";"Trafficking of AMPA receptors" XP_046738904.1 14 KEGG: 00592+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;Reactome: R-HSA-1482788;MetaCyc: PWY-8051;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;KEGG: 00591+3.1.1.4;Reactome: R-HSA-975634 "alpha-Linolenic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Arachidonic acid metabolism";"Plasmalogen degradation";"Acyl chain remodelling of PC";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Linoleic acid metabolism";"Retinoid metabolism and transport" XP_046741583.1 2 Reactome: R-HSA-204005;Reactome: R-HSA-5694530 "COPII-mediated vesicle transport";"Cargo concentration in the ER" XP_046751413.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046742975.1 1 Reactome: R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins" XP_046751354.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046744317.1 12 Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-141444 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046739838.1 4 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-6794361;Reactome: R-HSA-5250958 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Neurexins and neuroligins";"Toxicity of botulinum toxin type B (BoNT/B)" XP_046750885.1 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" XP_046735249.1 2 Reactome: R-HSA-6811436;Reactome: R-HSA-8876198 "COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs" XP_046753285.1 2 Reactome: R-HSA-3238698;Reactome: R-HSA-373080 "WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)" XP_046739777.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-7656;MetaCyc: PWY-6733;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782 "Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis" XP_046739310.1 13 Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557 "Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis" XP_046748503.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046750005.1 27 Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-168276;Reactome: R-HSA-191859;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-3108214;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107 "NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"NS1 Mediated Effects on Host Pathways";"snRNP Assembly";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"SUMOylation of DNA damage response and repair proteins";"HCMV Late Events";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)" XP_046741073.1 1 Reactome: R-HSA-72165 "mRNA Splicing - Minor Pathway" XP_046745101.1 1 Reactome: R-HSA-73621 "Pyrimidine catabolism" XP_046751546.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046743008.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046742878.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046743139.1 6 Reactome: R-HSA-6807505;Reactome: R-HSA-76071;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;Reactome: R-HSA-749476;KEGG: 00740+3.1.3.2 "RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Phosphate acquisition";"Thiamine metabolism";"RNA Polymerase III Abortive And Retractive Initiation";"Riboflavin metabolism" XP_046744090.1 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" XP_046751117.1 13 Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression" XP_046734221.1 11 Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-170670;Reactome: R-HSA-418555 "Adenylate cyclase activating pathway";"Purine metabolism";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"G alpha (z) signalling events";"PKA activation";"Hedgehog 'off' state";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"Adenylate cyclase inhibitory pathway";"G alpha (s) signalling events" XP_046739818.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046751015.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046740071.1 1 Reactome: R-HSA-1483191 "Synthesis of PC" XP_046747239.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046744757.1 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" XP_046748796.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046740676.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046749966.1 4 KEGG: 00640+1.2.1.27;MetaCyc: PWY-5642;Reactome: R-HSA-70895;KEGG: 00280+1.2.1.27 "Propanoate metabolism";"2,4-dinitrotoluene degradation";"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation" XP_046737908.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046743039.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046748182.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046749472.1 11 MetaCyc: PWY-6352;Reactome: R-HSA-168138;Reactome: R-HSA-1660514;Reactome: R-HSA-5668599;Reactome: R-HSA-1660499;KEGG: 04070+2.7.1.137;KEGG: 00562+2.7.1.137;Reactome: R-HSA-1632852;Reactome: R-HSA-1660517;Reactome: R-HSA-1660516;Reactome: R-HSA-109704 "3-phosphoinositide biosynthesis";"Toll Like Receptor 9 (TLR9) Cascade";"Synthesis of PIPs at the Golgi membrane";"RHO GTPases Activate NADPH Oxidases";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Macroautophagy";"Synthesis of PIPs at the late endosome membrane";"Synthesis of PIPs at the early endosome membrane";"PI3K Cascade" XP_046741409.1 10 Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-3214847;Reactome: R-HSA-76042 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"HATs acetylate histones";"RNA Polymerase II Transcription Initiation And Promoter Clearance" XP_046744155.1 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" XP_046734889.1 9 Reactome: R-HSA-2029482;Reactome: R-HSA-5218920;Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-2871796;Reactome: R-HSA-114604;Reactome: R-HSA-4420097;Reactome: R-HSA-194840;Reactome: R-HSA-2871809 "Regulation of actin dynamics for phagocytic cup formation";"VEGFR2 mediated vascular permeability";"G alpha (12/13) signalling events";"NRAGE signals death through JNK";"FCERI mediated MAPK activation";"GPVI-mediated activation cascade";"VEGFA-VEGFR2 Pathway";"Rho GTPase cycle";"FCERI mediated Ca+2 mobilization" XP_046749430.1 2 Reactome: R-HSA-8964038;Reactome: R-HSA-6798695 "LDL clearance";"Neutrophil degranulation" XP_046745118.1 16 Reactome: R-HSA-1810476;Reactome: R-HSA-5602498;Reactome: R-HSA-1236974;Reactome: R-HSA-3134963;Reactome: R-HSA-975138;Reactome: R-HSA-1257604;Reactome: R-HSA-5603041;Reactome: R-HSA-166058;Reactome: R-HSA-5603037;Reactome: R-HSA-9020702;Reactome: R-HSA-209543;Reactome: R-HSA-5602680;Reactome: R-HSA-975110;Reactome: R-HSA-6811558;Reactome: R-HSA-975871;Reactome: R-HSA-975155 "RIP-mediated NFkB activation via ZBP1";"MyD88 deficiency (TLR2/4)";"ER-Phagosome pathway";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"PIP3 activates AKT signaling";"IRAK4 deficiency (TLR2/4)";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"IRAK4 deficiency (TLR5)";"Interleukin-1 signaling";"p75NTR recruits signalling complexes";"MyD88 deficiency (TLR5)";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"MyD88 cascade initiated on plasma membrane";"MyD88 dependent cascade initiated on endosome" XP_046748113.1 5 MetaCyc: PWY-5514;Reactome: R-HSA-70171;MetaCyc: PWY-6855;MetaCyc: PWY-6906;KEGG: 00520+3.5.99.6 "UDP-N-acetyl-D-galactosamine biosynthesis II";"Glycolysis";"Chitin degradation I (archaea)";"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism" XP_046746396.1 4 KEGG: 00592+3.1.1.32;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.32 "alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Glycerophospholipid metabolism" XP_046743599.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046735877.1 2 Reactome: R-HSA-5218920;Reactome: R-HSA-418990 "VEGFR2 mediated vascular permeability";"Adherens junctions interactions" XP_046750873.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046748056.1 9 MetaCyc: PWY-8004;KEGG: 00010+1.2.1.12;MetaCyc: PWY-7003;Reactome: R-HSA-70171;Reactome: R-HSA-70263;MetaCyc: PWY-6901;MetaCyc: PWY-5484;KEGG: 00710+1.2.1.12;MetaCyc: PWY-1042 "Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Glycerol degradation to butanol";"Glycolysis";"Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Glycolysis II (from fructose 6-phosphate)";"Carbon fixation in photosynthetic organisms";"Glycolysis IV (plant cytosol)" XP_046750776.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046744005.1 5 Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-390450;Reactome: R-HSA-6814122;Reactome: R-HSA-389957 "Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC" XP_046752799.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046739555.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6784531 "Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus" XP_046747717.1 3 Reactome: R-HSA-416476;Reactome: R-HSA-881907;Reactome: R-HSA-375276 "G alpha (q) signalling events";"Gastrin-CREB signalling pathway via PKC and MAPK";"Peptide ligand-binding receptors" XP_046753683.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046754053.1 5 Reactome: R-HSA-350054;Reactome: R-HSA-1912420;Reactome: R-HSA-5083630;Reactome: R-HSA-1912408;Reactome: R-HSA-1912399 "Notch-HLH transcription pathway";"Pre-NOTCH Processing in Golgi";"Defective LFNG causes SCDO3";"Pre-NOTCH Transcription and Translation";"Pre-NOTCH Processing in the Endoplasmic Reticulum" XP_046753328.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046753757.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046750163.1 6 Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-389957;Reactome: R-HSA-6814122;Reactome: R-HSA-5620922 "Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"BBSome-mediated cargo-targeting to cilium" XP_046751146.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046735290.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046740588.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046744162.1 1 Reactome: R-HSA-1362409 "Mitochondrial iron-sulfur cluster biogenesis" XP_046752353.1 1 Reactome: R-HSA-176974 "Unwinding of DNA" XP_046739019.1 3 KEGG: 00970+2.1.2.9;Reactome: R-HSA-5368286;KEGG: 00670+2.1.2.9 "Aminoacyl-tRNA biosynthesis";"Mitochondrial translation initiation";"One carbon pool by folate" XP_046744893.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046748579.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046741703.1 16 Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-72689 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits" XP_046748877.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046749879.1 4 Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" XP_046746299.1 6 Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-429958 "Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease" XP_046736459.1 1 Reactome: R-HSA-112126 "ALKBH3 mediated reversal of alkylation damage" XP_046752505.1 7 KEGG: 00270+2.5.1.22;KEGG: 00480+2.5.1.22;KEGG: 00480+2.5.1.16;KEGG: 00330+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00270+2.5.1.16;KEGG: 00330+2.5.1.22 "Cysteine and methionine metabolism";"Glutathione metabolism";"Glutathione metabolism";"Arginine and proline metabolism";"Metabolism of polyamines";"Cysteine and methionine metabolism";"Arginine and proline metabolism" XP_046751803.1 2 Reactome: R-HSA-400253;Reactome: R-HSA-2151201 "Circadian Clock";"Transcriptional activation of mitochondrial biogenesis" XP_046744132.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046740600.1 1 Reactome: R-HSA-203927 "MicroRNA (miRNA) biogenesis" XP_046747603.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046735464.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" XP_046751795.1 1 Reactome: R-HSA-6790901 "rRNA modification in the nucleus and cytosol" XP_046748154.1 4 Reactome: R-HSA-9018519;Reactome: R-HSA-3371568;Reactome: R-HSA-3371497;Reactome: R-HSA-8939211 "Estrogen-dependent gene expression";"Attenuation phase";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"ESR-mediated signaling" XP_046749600.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046745780.1 3 Reactome: R-HSA-112311;Reactome: R-HSA-1483191;Reactome: R-HSA-422085 "Neurotransmitter clearance";"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin" XP_046742720.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046749906.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046745986.1 1 Reactome: R-HSA-426486 "Small interfering RNA (siRNA) biogenesis" XP_046747462.1 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" XP_046738483.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046747884.1 2 Reactome: R-HSA-427413;Reactome: R-HSA-3214815 "NoRC negatively regulates rRNA expression";"HDACs deacetylate histones" XP_046738255.1 4 Reactome: R-HSA-196757;KEGG: 00970+2.1.2.9;KEGG: 00670+1.5.1.6;KEGG: 00670+2.1.2.9 "Metabolism of folate and pterines";"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"One carbon pool by folate" XP_046740798.1 11 Reactome: R-HSA-383280;Reactome: R-HSA-1368108;Reactome: R-HSA-1368082;Reactome: R-HSA-2151201;Reactome: R-HSA-212436;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-400206 "Nuclear Receptor transcription pathway";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"RORA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"Generic Transcription Pathway";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"Estrogen-dependent gene expression";"Regulation of lipid metabolism by PPARalpha" XP_046745983.1 1 Reactome: R-HSA-426486 "Small interfering RNA (siRNA) biogenesis" XP_046745264.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046744494.1 9 Reactome: R-HSA-2173796;Reactome: R-HSA-69202;Reactome: R-HSA-69231;Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-1362300;Reactome: R-HSA-6804114 "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Cyclin E associated events during G1/S transition";"Cyclin D associated events in G1";"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest" XP_046738625.1 2 Reactome: R-HSA-936837;Reactome: R-HSA-6798695 "Ion transport by P-type ATPases";"Neutrophil degranulation" XP_046742217.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046746659.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046743589.1 7 MetaCyc: PWY-7511;Reactome: R-HSA-2122948;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096 "Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus" XP_046744355.1 12 Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878 "Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport" XP_046737726.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046741239.1 5 Reactome: R-HSA-5693607;Reactome: R-HSA-5693571;Reactome: R-HSA-69473;Reactome: R-HSA-5693565;Reactome: R-HSA-5689901 "Processing of DNA double-strand break ends";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Metalloprotease DUBs" XP_046746647.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046737984.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046752334.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046743956.1 20 Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-5685938;Reactome: R-HSA-5655862;Reactome: R-HSA-5693616;Reactome: R-HSA-6782135;Reactome: R-HSA-5656121;Reactome: R-HSA-5656169;Reactome: R-HSA-110314;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-6804756;Reactome: R-HSA-6782210;Reactome: R-HSA-5693607;Reactome: R-HSA-5696397;Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-69473;Reactome: R-HSA-110320;Reactome: R-HSA-176187 "Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Single Strand Annealing (SSA)";"Translesion synthesis by POLK";"Presynaptic phase of homologous DNA pairing and strand exchange";"Dual incision in TC-NER";"Translesion synthesis by POLI";"Termination of translesion DNA synthesis";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Regulation of TP53 Activity through Phosphorylation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Processing of DNA double-strand break ends";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Dual Incision in GG-NER";"Polymerase switching";"G2/M DNA damage checkpoint";"Translesion Synthesis by POLH";"Activation of ATR in response to replication stress" XP_046739341.1 4 Reactome: R-HSA-5678895;Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;Reactome: R-HSA-382556 "Defective CFTR causes cystic fibrosis";"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ABC-family proteins mediated transport" XP_046753293.1 4 Reactome: R-HSA-2500257;Reactome: R-HSA-2470946;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052 "Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion" XP_046748718.1 7 Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912 "Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane" XP_046740569.1 7 Reactome: R-HSA-3214841;Reactome: R-HSA-8953750;Reactome: R-HSA-8943724;Reactome: R-HSA-9609690;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472 "PKMTs methylate histone lysines";"Transcriptional Regulation by E2F6";"Regulation of PTEN gene transcription";"HCMV Early Events";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis" XP_046745080.1 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046750833.1 52 Reactome: R-HSA-167161;Reactome: R-HSA-167287;Reactome: R-HSA-168325;Reactome: R-HSA-72086;Reactome: R-HSA-167238;Reactome: R-HSA-73980;Reactome: R-HSA-72163;Reactome: R-HSA-73863;Reactome: R-HSA-72165;Reactome: R-HSA-8851708;Reactome: R-HSA-113418;Reactome: R-HSA-76061;Reactome: R-HSA-427413;Reactome: R-HSA-203927;Reactome: R-HSA-674695;Reactome: R-HSA-73780;Reactome: R-HSA-73776;Reactome: R-HSA-5617472;Reactome: R-HSA-77075;Reactome: R-HSA-5578749;Reactome: R-HSA-6807505;Reactome: R-HSA-73779;Reactome: R-HSA-167246;Reactome: R-HSA-5250924;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-167162;Reactome: R-HSA-73772;Reactome: R-HSA-5601884;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-75955;Reactome: R-HSA-6782210;Reactome: R-HSA-72203;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-76071;Reactome: R-HSA-6796648;Reactome: R-HSA-75953;Reactome: R-HSA-73762;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-9018519;Reactome: R-HSA-76066;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-6782135;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-112382 "HIV Transcription Initiation";"HIV elongation arrest and recovery";"Viral Messenger RNA Synthesis";"mRNA Capping";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Termination";"mRNA Splicing - Major Pathway";"RNA Polymerase I Transcription Termination";"mRNA Splicing - Minor Pathway";"Signaling by FGFR2 IIIa TM";"Formation of the Early Elongation Complex";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"NoRC negatively regulates rRNA expression";"MicroRNA (miRNA) biogenesis";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase III Chain Elongation";"RNA Polymerase II Promoter Escape";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcriptional regulation by small RNAs";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Tat-mediated elongation of the HIV-1 transcript";"B-WICH complex positively regulates rRNA expression";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Promoter Escape";"PIWI-interacting RNA (piRNA) biogenesis";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"Estrogen-dependent gene expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Dual incision in TC-NER";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Formation of RNA Pol II elongation complex" XP_046745474.1 5 Reactome: R-HSA-5687128;Reactome: R-HSA-176407;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "MAPK6/MAPK4 signaling";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046750566.1 52 Reactome: R-HSA-8851708;Reactome: R-HSA-113418;Reactome: R-HSA-72165;Reactome: R-HSA-73863;Reactome: R-HSA-72163;Reactome: R-HSA-73980;Reactome: R-HSA-167238;Reactome: R-HSA-167161;Reactome: R-HSA-167287;Reactome: R-HSA-168325;Reactome: R-HSA-72086;Reactome: R-HSA-5601884;Reactome: R-HSA-73772;Reactome: R-HSA-167162;Reactome: R-HSA-5250924;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-167246;Reactome: R-HSA-5578749;Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-5617472;Reactome: R-HSA-77075;Reactome: R-HSA-73780;Reactome: R-HSA-73776;Reactome: R-HSA-76061;Reactome: R-HSA-427413;Reactome: R-HSA-674695;Reactome: R-HSA-203927;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-76071;Reactome: R-HSA-6782210;Reactome: R-HSA-72203;Reactome: R-HSA-167242;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-76042;Reactome: R-HSA-6781823;Reactome: R-HSA-76066;Reactome: R-HSA-167172;Reactome: R-HSA-6781827;Reactome: R-HSA-9018519;Reactome: R-HSA-75953;Reactome: R-HSA-73762;Reactome: R-HSA-6796648 "Signaling by FGFR2 IIIa TM";"Formation of the Early Elongation Complex";"mRNA Splicing - Minor Pathway";"RNA Polymerase I Transcription Termination";"mRNA Splicing - Major Pathway";"RNA Polymerase III Transcription Termination";"Pausing and recovery of Tat-mediated HIV elongation";"HIV Transcription Initiation";"HIV elongation arrest and recovery";"Viral Messenger RNA Synthesis";"mRNA Capping";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase I Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"B-WICH complex positively regulates rRNA expression";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"Tat-mediated elongation of the HIV-1 transcript";"Transcriptional regulation by small RNAs";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase III Chain Elongation";"RNA Polymerase II Promoter Escape";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Pre-transcription Events";"MicroRNA (miRNA) biogenesis";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Processing of Capped Intron-Containing Pre-mRNA";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Transcription of the HIV genome";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes" XP_046748250.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046735540.1 1 Reactome: R-HSA-419771 "Opsins" XP_046740046.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046743354.1 3 Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "MHC class II antigen presentation";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046750211.1 10 Reactome: R-HSA-202424;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-2565942;Reactome: R-HSA-5684264;Reactome: R-HSA-5676590;Reactome: R-HSA-5607761;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664 "Downstream TCR signaling";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of PLK1 Activity at G2/M Transition";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"NIK-->noncanonical NF-kB signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"CLEC7A (Dectin-1) signaling";"Neddylation" XP_046742851.1 7 Reactome: R-HSA-3214815;Reactome: R-HSA-5625886;Reactome: R-HSA-983231;Reactome: R-HSA-3214842;Reactome: R-HSA-9018519;Reactome: R-HSA-9029569;Reactome: R-HSA-8943724 "HDACs deacetylate histones";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Factors involved in megakaryocyte development and platelet production";"HDMs demethylate histones";"Estrogen-dependent gene expression";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of PTEN gene transcription" XP_046741861.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046738369.1 2 Reactome: R-HSA-5578998;Reactome: R-HSA-174403 "Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)";"Glutathione synthesis and recycling" XP_046741257.1 11 Reactome: R-HSA-3560801;Reactome: R-HSA-3656237;Reactome: R-HSA-3656253;Reactome: R-HSA-2024096;Reactome: R-HSA-3560783;Reactome: R-HSA-2022928;Reactome: R-HSA-4420332;Reactome: R-HSA-1971475;Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-3000170 "Defective B3GAT3 causes JDSSDHD";"Defective EXT2 causes exostoses 2";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"HS-GAG degradation";"Defective B4GALT7 causes EDS, progeroid type";"HS-GAG biosynthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"A tetrasaccharide linker sequence is required for GAG synthesis";"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"Syndecan interactions" XP_046749508.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046737428.1 6 Reactome: R-HSA-429958;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-450513 "mRNA decay by 3' to 5' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" XP_046753272.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046741672.1 5 Reactome: R-HSA-70688;KEGG: 00250+1.2.1.88;Reactome: R-HSA-389661;MetaCyc: PWY-6853;KEGG: 00330+1.2.1.88 "Proline catabolism";"Alanine, aspartate and glutamate metabolism";"Glyoxylate metabolism and glycine degradation";"Ethylene biosynthesis II (microbes)";"Arginine and proline metabolism" XP_046739627.1 24 Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-6811436;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295 "Mitotic Prometaphase";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"COPI-independent Golgi-to-ER retrograde traffic";"Cilium Assembly";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"HCMV Early Events";"RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation" XP_046749900.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046740825.1 3 Reactome: R-HSA-189451;KEGG: 00860+2.5.1.141;MetaCyc: PWY-7856 "Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"Heme a biosynthesis" XP_046739577.1 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" XP_046738470.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046741680.1 1 KEGG: 00970+6.1.1.21 "Aminoacyl-tRNA biosynthesis" XP_046734715.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046742368.1 8 Reactome: R-HSA-428540;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Activation of RAC1";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046737449.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046747413.1 3 KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348 "Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition" XP_046744166.1 3 Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing" XP_046745083.1 10 KEGG: 00531+3.2.1.23;Reactome: R-HSA-2024096;MetaCyc: PWY-6807;KEGG: 00052+3.2.1.23;Reactome: R-HSA-2160916;Reactome: R-HSA-2206292;Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23 "Glycosaminoglycan degradation";"HS-GAG degradation";"Xyloglucan degradation II (exoglucanase)";"Galactose metabolism";"Hyaluronan uptake and degradation";"MPS VII - Sly syndrome";"Neutrophil degranulation";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series" XP_046742080.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046736181.1 8 KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Human papillomavirus infection";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Signaling by Hippo";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" XP_046751463.1 1 Reactome: R-HSA-211981 "Xenobiotics" XP_046751750.1 19 Reactome: R-HSA-3000497;Reactome: R-HSA-8856825;Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-381426;Reactome: R-HSA-8856828;Reactome: R-HSA-202733;Reactome: R-HSA-975634;Reactome: R-HSA-8964038;Reactome: R-HSA-8957275;Reactome: R-HSA-8964041;Reactome: R-HSA-8964026;Reactome: R-HSA-3000471;Reactome: R-HSA-5686938;Reactome: R-HSA-3000484;Reactome: R-HSA-3000480;Reactome: R-HSA-8963901;Reactome: R-HSA-8964046;Reactome: R-HSA-8963888 "Scavenging by Class H Receptors";"Cargo recognition for clathrin-mediated endocytosis";"Platelet sensitization by LDL";"VLDL assembly";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Clathrin-mediated endocytosis";"Cell surface interactions at the vascular wall";"Retinoid metabolism and transport";"LDL clearance";"Post-translational protein phosphorylation";"LDL remodeling";"Chylomicron clearance";"Scavenging by Class B Receptors";"Regulation of TLR by endogenous ligand";"Scavenging by Class F Receptors";"Scavenging by Class A Receptors";"Chylomicron remodeling";"VLDL clearance";"Chylomicron assembly" XP_046748370.1 9 Reactome: R-HSA-5693554;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-5685942;Reactome: R-HSA-69473;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)";"G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange" XP_046736739.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046744046.1 3 Reactome: R-HSA-381038;Reactome: R-HSA-8957275;Reactome: R-HSA-381426 "XBP1(S) activates chaperone genes";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" XP_046753517.1 4 Reactome: R-HSA-499943;MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541 "Interconversion of nucleotide di- and triphosphates";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Abacavir metabolism" XP_046741335.1 10 Reactome: R-HSA-9022692;Reactome: R-HSA-427413;Reactome: R-HSA-983231;Reactome: R-HSA-9615017;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-9022538;Reactome: R-HSA-9022699;Reactome: R-HSA-3899300;Reactome: R-HSA-8936459 "Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates neuronal receptors and channels";"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046739165.1 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" XP_046751288.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046738032.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046737072.1 29 Reactome: R-HSA-73772;Reactome: R-HSA-112382;Reactome: R-HSA-167162;Reactome: R-HSA-167158;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-5696395;Reactome: R-HSA-76042;Reactome: R-HSA-167246;Reactome: R-HSA-73779;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-73762;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-427413;Reactome: R-HSA-113418;Reactome: R-HSA-5696400;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-72086;Reactome: R-HSA-167161;Reactome: R-HSA-6782210;Reactome: R-HSA-75955;Reactome: R-HSA-167200 "RNA Polymerase I Promoter Escape";"Formation of RNA Pol II elongation complex";"RNA Polymerase II HIV Promoter Escape";"Formation of the HIV-1 Early Elongation Complex";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Formation of Incision Complex in GG-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"NoRC negatively regulates rRNA expression";"Formation of the Early Elongation Complex";"Dual Incision in GG-NER";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"mRNA Capping";"HIV Transcription Initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat" XP_046752713.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046739579.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046753107.1 57 Reactome: R-HSA-450408;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-382556;Reactome: R-HSA-6798695;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-9010553;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-8939902;Reactome: R-HSA-5689880;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-1236974;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-75815;Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5607761;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-5676590;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-69601;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-983168 "AUF1 (hnRNP D0) binds and destabilizes mRNA";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Neddylation";"Degradation of AXIN";"ABC-family proteins mediated transport";"Neutrophil degranulation";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of expression of SLITs and ROBOs";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Regulation of RUNX2 expression and activity";"Ub-specific processing proteases";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"ER-Phagosome pathway";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Dectin-1 mediated noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"NIK-->noncanonical NF-kB signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Downstream TCR signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046734840.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046753178.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046740341.1 1 Reactome: R-HSA-419037 "NCAM1 interactions" XP_046746210.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046749310.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046741669.1 3 Reactome: R-HSA-6783310;Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Fanconi Anemia Pathway";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046746094.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046749405.1 17 KEGG: 00240+2.7.4.6;MetaCyc: PWY-7198;MetaCyc: PWY-7205;MetaCyc: PWY-7221;MetaCyc: PWY-7227;MetaCyc: PWY-7210;MetaCyc: PWY-7226;MetaCyc: PWY-6545;MetaCyc: PWY-7224;MetaCyc: PWY-7187;MetaCyc: PWY-7222;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7176;MetaCyc: PWY-7184;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7220;MetaCyc: PWY-7197 "Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"CMP phosphorylation";"Guanosine ribonucleotides de novo biosynthesis";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation" XP_046743209.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" XP_046736472.1 14 Reactome: R-HSA-5655862;Reactome: R-HSA-5696397;Reactome: R-HSA-6782210;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-110314;Reactome: R-HSA-110320;Reactome: R-HSA-5685942;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-5656121;Reactome: R-HSA-5656169 "Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion Synthesis by POLH";"HDR through Homologous Recombination (HRR)";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Polymerase switching";"Translesion synthesis by POLI";"Termination of translesion DNA synthesis" XP_046736495.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046753053.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6798695 "COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation" XP_046746971.1 7 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046736251.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046744819.1 5 Reactome: R-HSA-8943724;Reactome: R-HSA-6804758;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-73762 "Regulation of PTEN gene transcription";"Regulation of TP53 Activity through Acetylation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"RNA Polymerase I Transcription Initiation" XP_046751363.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046746860.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046744081.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046742928.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046747697.1 2 Reactome: R-HSA-5683371;Reactome: R-HSA-1369007 "Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)";"Mitochondrial ABC transporters" XP_046747020.1 11 Reactome: R-HSA-2559580;Reactome: R-HSA-450302;KEGG: 05165+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Oxidative Stress Induced Senescence";"activated TAK1 mediates p38 MAPK activation";"Human papillomavirus infection";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" XP_046750214.1 2 KEGG: 00970+6.1.1.11;MetaCyc: PWY-6281 "Aminoacyl-tRNA biosynthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)" XP_046740280.1 5 Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" XP_046753968.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046743112.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046736777.1 5 Reactome: R-HSA-6798695;Reactome: R-HSA-1660499;Reactome: R-HSA-8873719;Reactome: R-HSA-1445148;Reactome: R-HSA-8876198 "Neutrophil degranulation";"Synthesis of PIPs at the plasma membrane";"RAB geranylgeranylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RAB GEFs exchange GTP for GDP on RABs" XP_046746090.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046747714.1 3 Reactome: R-HSA-6798695;Reactome: R-HSA-6807004;Reactome: R-HSA-202427 "Neutrophil degranulation";"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains" XP_046752136.1 6 Reactome: R-HSA-5632968;Reactome: R-HSA-5632928;Reactome: R-HSA-5632927;Reactome: R-HSA-5358606;Reactome: R-HSA-5358565;Reactome: R-HSA-6796648 "Defective Mismatch Repair Associated With MSH6";"Defective Mismatch Repair Associated With MSH2";"Defective Mismatch Repair Associated With MSH3";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"TP53 Regulates Transcription of DNA Repair Genes" XP_046752653.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046753925.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046747349.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046741581.1 5 MetaCyc: PWY-5653;Reactome: R-HSA-196807;KEGG: 00760+2.7.7.18;MetaCyc: PWY-7761;MetaCyc: PWY-5381 "NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Pyridine nucleotide cycling (plants)" XP_046737139.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046749545.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046741114.1 3 Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955 "Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation" XP_046734092.1 13 Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane" XP_046742254.1 16 Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72649 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Translation initiation complex formation" XP_046750537.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046737016.1 5 MetaCyc: PWY-5084;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00380+1.2.4.2 "2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"Citrate cycle (TCA cycle)";"Tryptophan metabolism" XP_046750636.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046743132.1 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" XP_046742007.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046747841.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046744693.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046750037.1 2 Reactome: R-HSA-69273;Reactome: R-HSA-8862803 "Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" XP_046746960.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046754031.1 10 Reactome: R-HSA-6807004;Reactome: R-HSA-9635644;Reactome: R-HSA-8875360;Reactome: R-HSA-8856828;Reactome: R-HSA-9636383;Reactome: R-HSA-432720;Reactome: R-HSA-8856825;Reactome: R-HSA-917729;Reactome: R-HSA-182971;Reactome: R-HSA-5689880 "Negative regulation of MET activity";"Inhibition of membrane repair";"InlB-mediated entry of Listeria monocytogenes into host cell";"Clathrin-mediated endocytosis";"Prevention of phagosomal-lysosomal fusion";"Lysosome Vesicle Biogenesis";"Cargo recognition for clathrin-mediated endocytosis";"Endosomal Sorting Complex Required For Transport (ESCRT)";"EGFR downregulation";"Ub-specific processing proteases" XP_046751201.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046745473.1 5 MetaCyc: PWY-6892;MetaCyc: PWY-7560;KEGG: 00730+2.2.1.7;MetaCyc: PWY-6891;KEGG: 00900+2.2.1.7 "Thiazole biosynthesis I (facultative anaerobic bacteria)";"Methylerythritol phosphate pathway II";"Thiamine metabolism";"Thiazole biosynthesis II (aerobic bacteria)";"Terpenoid backbone biosynthesis" XP_046749851.1 6 KEGG: 05235+3.1.3.16;Reactome: R-HSA-163560;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-400253;Reactome: R-HSA-2173788 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"Triglyceride catabolism";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"Circadian Clock";"Downregulation of TGF-beta receptor signaling" XP_046750091.1 30 Reactome: R-HSA-8876198;Reactome: R-HSA-389357;Reactome: R-HSA-392451;Reactome: R-HSA-6804757;Reactome: R-HSA-198323;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-8941332;Reactome: R-HSA-6804758;Reactome: R-HSA-69656;KEGG: 05165+2.7.11.1;Reactome: R-HSA-8948751;KEGG: 04926+2.7.11.1;Reactome: R-HSA-199418;Reactome: R-HSA-198693;KEGG: 04714+2.7.11.1;Reactome: R-HSA-9614399;Reactome: R-HSA-1358803;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-6804759;Reactome: R-HSA-5674400;KEGG: 04151+2.7.11.1;Reactome: R-HSA-211163;Reactome: R-HSA-5218920;Reactome: R-HSA-111447;Reactome: R-HSA-389513;Reactome: R-HSA-1257604;Reactome: R-HSA-9634638;Reactome: R-HSA-69202 "RAB GEFs exchange GTP for GDP on RABs";"CD28 dependent PI3K/Akt signaling";"G beta:gamma signalling through PI3Kgamma";"Regulation of TP53 Degradation";"AKT phosphorylates targets in the cytosol";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"RUNX2 regulates genes involved in cell migration";"Regulation of TP53 Activity through Acetylation";"Cyclin A:Cdk2-associated events at S phase entry";"Human papillomavirus infection";"Regulation of PTEN stability and activity";"Relaxin signaling pathway";"Negative regulation of the PI3K/AKT network";"AKT phosphorylates targets in the nucleus";"Thermogenesis";"Regulation of localization of FOXO transcription factors";"Downregulation of ERBB2:ERBB3 signaling";"Human cytomegalovirus infection";"TP53 Regulates Metabolic Genes";"Regulation of TP53 Activity through Association with Co-factors";"Constitutive Signaling by AKT1 E17K in Cancer";"PI3K-Akt signaling pathway";"AKT-mediated inactivation of FOXO1A";"VEGFR2 mediated vascular permeability";"Activation of BAD and translocation to mitochondria";"CTLA4 inhibitory signaling";"PIP3 activates AKT signaling";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Cyclin E associated events during G1/S transition" XP_046753556.1 4 Reactome: R-HSA-4717374;Reactome: R-HSA-162699;Reactome: R-HSA-4719377;Reactome: R-HSA-4719360 "Defective DPM1 causes DPM1-CDG (CDG-1e)";"Synthesis of dolichyl-phosphate mannose";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM3 causes DPM3-CDG (CDG-1o)" XP_046744779.1 2 Reactome: R-HSA-2024096;Reactome: R-HSA-2206307 "HS-GAG degradation";"MPS IIIA - Sanfilippo syndrome A" XP_046740318.1 2 Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" XP_046740821.1 33 Reactome: R-HSA-141444;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-2500257;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-5578749;Reactome: R-HSA-5663220;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-159227;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-9609690;Reactome: R-HSA-168276;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-68877;Reactome: R-HSA-1169408 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transcriptional regulation by small RNAs";"RHO GTPases Activate Formins";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Transport of the SLBP independent Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Early Events";"NS1 Mediated Effects on Host Pathways";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Mitotic Prometaphase";"ISG15 antiviral mechanism" XP_046738726.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046733880.1 6 Reactome: R-HSA-1660516;Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.66;MetaCyc: PWY-6368;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.66 "Synthesis of PIPs at the early endosome membrane";"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system" XP_046745259.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046746672.1 11 Reactome: R-HSA-4043916;MetaCyc: PWY-7456;MetaCyc: PWY-3861;KEGG: 00520+5.3.1.8;MetaCyc: PWY-6992;Reactome: R-HSA-446205;MetaCyc: PWY-882;KEGG: 00051+5.3.1.8;MetaCyc: PWY-7586;MetaCyc: PWY-3881;MetaCyc: PWY-5659 "Defective MPI causes MPI-CDG (CDG-1b)";"Beta-(1,4)-mannan degradation";"Mannitol degradation II";"Amino sugar and nucleotide sugar metabolism";"1,5-anhydrofructose degradation";"Synthesis of GDP-mannose";"L-ascorbate biosynthesis I (L-galactose pathway)";"Fructose and mannose metabolism";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Mannitol biosynthesis";"GDP-mannose biosynthesis" XP_046739631.1 3 Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-8963901 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Chylomicron remodeling" XP_046739609.1 3 Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-8963901 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Chylomicron remodeling" XP_046742677.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046745647.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046749105.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046752883.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046746151.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046743206.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046743720.1 1 Reactome: R-HSA-5666185 "RHO GTPases Activate Rhotekin and Rhophilins" XP_046742876.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046747720.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046751749.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046736807.1 5 Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-75035;Reactome: R-HSA-5628897;Reactome: R-HSA-5625740 "Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes";"RHO GTPases activate PKNs" XP_046749733.1 5 Reactome: R-HSA-6798695;Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;Reactome: R-HSA-3270619;Reactome: R-HSA-164843 "Neutrophil degranulation";"Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"IRF3-mediated induction of type I IFN";"2-LTR circle formation" XP_046748087.1 4 MetaCyc: PWY-7394;KEGG: 00230+4.1.1.97;MetaCyc: PWY-5691;MetaCyc: PWY-7849 "Urate conversion to allantoin II";"Purine metabolism";"Urate conversion to allantoin I";"Urate conversion to allantoin III" XP_046753853.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046752514.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046737515.1 6 KEGG: 00380+1.14.13.9;Reactome: R-HSA-71240;MetaCyc: PWY-7717;MetaCyc: PWY-5651;MetaCyc: PWY-6309;MetaCyc: PWY-7765 "Tryptophan metabolism";"Tryptophan catabolism";"3-hydroxy-4-methyl-anthranilate biosynthesis I";"L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde";"L-tryptophan degradation XI (mammalian, via kynurenine)";"3-hydroxy-4-methyl-anthranilate biosynthesis II" XP_046738018.1 3 Reactome: R-HSA-8876725;Reactome: R-HSA-2514859;KEGG: 00310+2.1.1.60 "Protein methylation";"Inactivation, recovery and regulation of the phototransduction cascade";"Lysine degradation" XP_046752225.1 2 Reactome: R-HSA-430039;MetaCyc: PWY-6938 "mRNA decay by 5' to 3' exoribonuclease";"NADH repair" XP_046743783.1 1 Reactome: R-HSA-9617828 "FOXO-mediated transcription of cell cycle genes" XP_046753926.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046736150.1 1 Reactome: R-HSA-430039 "mRNA decay by 5' to 3' exoribonuclease" XP_046752219.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046736810.1 5 Reactome: R-HSA-5628897;Reactome: R-HSA-5625740;Reactome: R-HSA-75035;Reactome: R-HSA-111447;Reactome: R-HSA-1445148 "TP53 Regulates Metabolic Genes";"RHO GTPases activate PKNs";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046753238.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046736443.1 4 MetaCyc: PWY-6829;Reactome: R-HSA-6782315;MetaCyc: PWY-7285;MetaCyc: PWY-7286 "Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol";"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis" XP_046739131.1 6 Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72187;Reactome: R-HSA-73856 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination" XP_046742904.1 5 Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-6804757;Reactome: R-HSA-1257604 "Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"Regulation of TP53 Degradation";"PIP3 activates AKT signaling" XP_046741330.1 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" XP_046749557.1 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" XP_046736861.1 2 Reactome: R-HSA-168276;Reactome: R-HSA-1169408 "NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism" XP_046744441.1 18 KEGG: 00592+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-1482922;MetaCyc: PWY-7783;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7417;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;Reactome: R-HSA-1482788;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482925;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8051;Reactome: R-HSA-1482801 "alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PI";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Synthesis of PA";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Acyl chain remodelling of PC";"Arachidonic acid metabolism";"Acyl chain remodelling of PG";"Linoleic acid metabolism";"Anandamide biosynthesis I";"Acyl chain remodelling of PS" XP_046743061.1 26 Reactome: R-HSA-389977;Reactome: R-HSA-9648025;Reactome: R-HSA-389960;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-190861 "Post-chaperonin tubulin folding pathway";"EML4 and NUDC in mitotic spindle formation";"Formation of tubulin folding intermediates by CCT/TriC";"Separation of Sister Chromatids";"Cilium Assembly";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"COPI-mediated anterograde transport";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly" XP_046742287.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046734008.1 6 Reactome: R-HSA-429958;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-6791226 "mRNA decay by 3' to 5' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046753072.1 1 Reactome: R-HSA-912446 "Meiotic recombination" XP_046742158.1 14 MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7725;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6598 "Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis" XP_046752150.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046742003.1 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" XP_046744457.1 4 Reactome: R-HSA-1660662;MetaCyc: PWY-6483;KEGG: 00600+3.5.1.23;MetaCyc: PWY-7119 "Glycosphingolipid metabolism";"Ceramide degradation (generic)";"Sphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)" XP_046749136.1 7 Reactome: R-HSA-156711;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-1362300 "Polo-like kinase mediated events";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" XP_046740334.1 6 Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-456926;Reactome: R-HSA-428930;Reactome: R-HSA-399997 "G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor";"Acetylcholine regulates insulin secretion" XP_046739923.1 5 Reactome: R-HSA-1266695;Reactome: R-HSA-3214858;Reactome: R-HSA-201722;Reactome: R-HSA-8939243;Reactome: R-HSA-3247509 "Interleukin-7 signaling";"RMTs methylate histone arginines";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Chromatin modifying enzymes" XP_046737303.1 10 Reactome: R-HSA-1483166;KEGG: 00564+2.3.1.15;MetaCyc: PWY-7411;MetaCyc: PWY-8055;MetaCyc: PWY-8053;MetaCyc: PWY-5667;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.15;MetaCyc: PWY-6453;MetaCyc: PWY-8051 "Synthesis of PA";"Glycerophospholipid metabolism";"Phosphatidate biosynthesis (yeast)";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Stigma estolide biosynthesis";"Anandamide biosynthesis I" XP_046744789.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046749904.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046740490.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046743653.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046748715.1 7 Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes" XP_046744432.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046733881.1 6 Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.66;MetaCyc: PWY-6368;Reactome: R-HSA-1660516;KEGG: 00562+3.1.3.66;Reactome: R-HSA-1855183 "Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Synthesis of PIPs at the early endosome membrane";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol" XP_046744092.1 57 Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-382556;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-450408;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-202424;Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-1236974;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684 "FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"ABC-family proteins mediated transport";"Degradation of AXIN";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Downstream TCR signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"ER-Phagosome pathway";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"UCH proteinases";"Hedgehog 'on' state" XP_046739604.1 6 Reactome: R-HSA-8957275;Reactome: R-HSA-2173796;Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-381426;Reactome: R-HSA-5626467 "Post-translational protein phosphorylation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"RHO GTPases activate IQGAPs" XP_046734662.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046747407.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046734839.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046739921.1 5 Reactome: R-HSA-3247509;Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-1266695;Reactome: R-HSA-3214858 "Chromatin modifying enzymes";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"Interleukin-7 signaling";"RMTs methylate histone arginines" XP_046735567.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046749298.1 5 Reactome: R-HSA-6807004;Reactome: R-HSA-182971;Reactome: R-HSA-8856828;Reactome: R-HSA-8875360;Reactome: R-HSA-8856825 "Negative regulation of MET activity";"EGFR downregulation";"Clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis" XP_046735974.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046748824.1 16 Reactome: R-HSA-176407;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-141430;Reactome: R-HSA-8853884;Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-174048;Reactome: R-HSA-176412;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-174184;Reactome: R-HSA-176409;Reactome: R-HSA-176408 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Transcriptional Regulation by VENTX";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Cyclin B";"Phosphorylation of the APC/C";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Regulation of APC/C activators between G1/S and early anaphase" XP_046744425.1 6 Reactome: R-HSA-9022692;Reactome: R-HSA-3214815;Reactome: R-HSA-9022537;Reactome: R-HSA-1989781;Reactome: R-HSA-9029569;Reactome: R-HSA-9609690 "Regulation of MECP2 expression and activity";"HDACs deacetylate histones";"Loss of MECP2 binding ability to the NCoR/SMRT complex";"PPARA activates gene expression";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"HCMV Early Events" XP_046747489.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046742832.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046737086.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046734944.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046741580.1 14 MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7619 "(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis" XP_046741412.1 10 Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-3214847;Reactome: R-HSA-76042;Reactome: R-HSA-167162 "HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"HATs acetylate histones";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape" XP_046750248.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046743719.1 1 Reactome: R-HSA-5666185 "RHO GTPases Activate Rhotekin and Rhophilins" XP_046753549.1 8 Reactome: R-HSA-167590;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-9636467;Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-182218;Reactome: R-HSA-917977 "Nef Mediated CD4 Down-regulation";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Blockage of phagosome acidification";"Ion channel transport";"Amino acids regulate mTORC1";"Nef Mediated CD8 Down-regulation";"Transferrin endocytosis and recycling" XP_046739996.1 7 MetaCyc: PWY-7282;Reactome: R-HSA-73817;MetaCyc: PWY-6121;KEGG: 00230+2.4.2.14;MetaCyc: PWY-6277;KEGG: 00250+2.4.2.14;MetaCyc: PWY-6122 "4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Alanine, aspartate and glutamate metabolism";"5-aminoimidazole ribonucleotide biosynthesis II" XP_046743343.1 5 KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;Reactome: R-HSA-389661 "Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation" XP_046751290.1 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" XP_046737442.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046734888.1 9 Reactome: R-HSA-114604;Reactome: R-HSA-2871796;Reactome: R-HSA-193648;Reactome: R-HSA-2871809;Reactome: R-HSA-194840;Reactome: R-HSA-4420097;Reactome: R-HSA-5218920;Reactome: R-HSA-416482;Reactome: R-HSA-2029482 "GPVI-mediated activation cascade";"FCERI mediated MAPK activation";"NRAGE signals death through JNK";"FCERI mediated Ca+2 mobilization";"Rho GTPase cycle";"VEGFA-VEGFR2 Pathway";"VEGFR2 mediated vascular permeability";"G alpha (12/13) signalling events";"Regulation of actin dynamics for phagocytic cup formation" XP_046739254.1 1 Reactome: R-HSA-1614517 "Sulfide oxidation to sulfate" XP_046750670.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046751230.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046743521.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046751295.1 6 Reactome: R-HSA-8874211;Reactome: R-HSA-8963889;Reactome: R-HSA-1655829;Reactome: R-HSA-381426;Reactome: R-HSA-381033;Reactome: R-HSA-8957275 "CREB3 factors activate genes";"Assembly of active LPL and LIPC lipase complexes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"ATF6 (ATF6-alpha) activates chaperones";"Post-translational protein phosphorylation" XP_046737704.1 1 Reactome: R-HSA-8943724 "Regulation of PTEN gene transcription" XP_046751493.1 4 KEGG: 00860+2.5.1.61;MetaCyc: PWY-5189;MetaCyc: PWY-5188;Reactome: R-HSA-189451 "Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis II (from glycine)";"Tetrapyrrole biosynthesis I (from glutamate)";"Heme biosynthesis" XP_046739415.1 8 Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-9620244;MetaCyc: PWY-7221;Reactome: R-HSA-438066;Reactome: R-HSA-5673001;Reactome: R-HSA-9609736;KEGG: 00230+2.7.4.8 "Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Long-term potentiation";"Guanosine ribonucleotides de novo biosynthesis";"Unblocking of NMDA receptors, glutamate binding and activation";"RAF/MAP kinase cascade";"Assembly and cell surface presentation of NMDA receptors";"Purine metabolism" XP_046737715.1 1 Reactome: R-HSA-114608 "Platelet degranulation" XP_046738499.1 2 Reactome: R-HSA-5661270;KEGG: 00040+2.7.1.17 "Formation of xylulose-5-phosphate";"Pentose and glucuronate interconversions" XP_046746836.1 5 Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;Reactome: R-HSA-6798695;Reactome: R-HSA-164843;Reactome: R-HSA-3270619 "Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"Neutrophil degranulation";"2-LTR circle formation";"IRF3-mediated induction of type I IFN" XP_046736894.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046753264.1 1 MetaCyc: PWY-7379 "Mrna capping II" XP_046739928.1 7 MetaCyc: PWY-4702;KEGG: 00521+3.1.3.25;KEGG: 00562+3.1.3.25;MetaCyc: PWY-6363;MetaCyc: PWY-2301;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25 "Phytate degradation I";"Streptomycin biosynthesis";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Myo-inositol biosynthesis";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system" XP_046752752.1 1 Reactome: R-HSA-211981 "Xenobiotics" XP_046737235.1 32 Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-72203;Reactome: R-HSA-167242;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-9018519;Reactome: R-HSA-75953;Reactome: R-HSA-6796648;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-76042;Reactome: R-HSA-72163;Reactome: R-HSA-167238;Reactome: R-HSA-167287;Reactome: R-HSA-167161;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-113418;Reactome: R-HSA-8851708;Reactome: R-HSA-72165;Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-77075;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-167246 "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"Processing of Capped Intron-Containing Pre-mRNA";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Splicing - Major Pathway";"Pausing and recovery of Tat-mediated HIV elongation";"HIV elongation arrest and recovery";"HIV Transcription Initiation";"mRNA Capping";"Viral Messenger RNA Synthesis";"Formation of the Early Elongation Complex";"Signaling by FGFR2 IIIa TM";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript" XP_046745068.1 33 Reactome: R-HSA-168333;Reactome: R-HSA-9609690;Reactome: R-HSA-168276;Reactome: R-HSA-191859;Reactome: R-HSA-159227;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-5619107;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-2500257;Reactome: R-HSA-168271;Reactome: R-HSA-141444;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-5663220 "NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Early Events";"NS1 Mediated Effects on Host Pathways";"snRNP Assembly";"Transport of the SLBP independent Mature mRNA";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"Nuclear import of Rev protein";"Mitotic Prometaphase";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Resolution of Sister Chromatid Cohesion";"Transport of Ribonucleoproteins into the Host Nucleus";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"HCMV Late Events";"SUMOylation of DNA replication proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"RHO GTPases Activate Formins" XP_046749194.1 2 Reactome: R-HSA-6783310;Reactome: R-HSA-5693568 "Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates" XP_046736498.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046746107.1 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" XP_046743415.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046744215.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046742958.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046750983.1 2 Reactome: R-HSA-2514853;Reactome: R-HSA-2299718 "Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes" XP_046752109.1 1 Reactome: R-HSA-201681 "TCF dependent signaling in response to WNT" XP_046735260.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046734641.1 6 Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-5685938;Reactome: R-HSA-176187;Reactome: R-HSA-69473 "Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Single Strand Annealing (SSA)";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint" XP_046745616.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046736122.1 3 KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046742820.1 7 Reactome: R-HSA-70221;MetaCyc: PWY-6737;MetaCyc: PWY-6724;MetaCyc: PWY-7238;Reactome: R-HSA-6798695;MetaCyc: PWY-5941;KEGG: 00500+2.4.1.25 "Glycogen breakdown (glycogenolysis)";"Starch degradation V";"Starch degradation II";"Sucrose biosynthesis II";"Neutrophil degranulation";"Glycogen degradation II";"Starch and sucrose metabolism" XP_046748973.1 3 MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783 "Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis" XP_046752040.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046748959.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046742943.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" XP_046741490.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" XP_046750767.1 3 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" XP_046737629.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046749784.1 5 Reactome: R-HSA-6811558;Reactome: R-HSA-1257604;Reactome: R-HSA-5673001;Reactome: R-HSA-109704;Reactome: R-HSA-2219530 "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"PIP3 activates AKT signaling";"RAF/MAP kinase cascade";"PI3K Cascade";"Constitutive Signaling by Aberrant PI3K in Cancer" XP_046751783.1 2 Reactome: R-HSA-4755609;Reactome: R-HSA-446199 "Defective DHDDS causes retinitis pigmentosa 59";"Synthesis of Dolichyl-phosphate" XP_046745007.1 2 Reactome: R-HSA-532668;Reactome: R-HSA-6798695 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Neutrophil degranulation" XP_046751067.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046736695.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046750570.1 1 Reactome: R-HSA-427975 "Proton/oligopeptide cotransporters" XP_046752451.1 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" XP_046744784.1 7 MetaCyc: PWY-882;MetaCyc: PWY-7456;MetaCyc: PWY-7586;Reactome: R-HSA-446205;KEGG: 00051+5.4.2.8;KEGG: 00520+5.4.2.8;MetaCyc: PWY-5659 "L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-(1,4)-mannan degradation";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Synthesis of GDP-mannose";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"GDP-mannose biosynthesis" XP_046734895.1 5 Reactome: R-HSA-71336;KEGG: 00030+4.1.2.4;MetaCyc: PWY-8060;MetaCyc: PWY-7180;Reactome: R-HSA-6798695 "Pentose phosphate pathway";"Pentose phosphate pathway";"2-deoxy-D-ribose degradation I";"2-deoxy-alpha-D-ribose 1-phosphate degradation";"Neutrophil degranulation" XP_046737354.1 4 Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664 "DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation" XP_046744986.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046747804.1 8 Reactome: R-HSA-5140745;Reactome: R-HSA-190873;Reactome: R-HSA-8856825;Reactome: R-HSA-432720;Reactome: R-HSA-196025;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828;Reactome: R-HSA-5099900 "WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Gap junction degradation";"Cargo recognition for clathrin-mediated endocytosis";"Lysosome Vesicle Biogenesis";"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD4" XP_046747016.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046749648.1 8 Reactome: R-HSA-70171;KEGG: 00521+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00052+2.7.1.1 "Glycolysis";"Streptomycin biosynthesis";"Fructose and mannose metabolism";"Starch and sucrose metabolism";"Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Glycolysis / Gluconeogenesis";"Galactose metabolism" XP_046740051.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046749828.1 3 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221;Reactome: R-HSA-420029 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Tight junction interactions" XP_046736805.1 10 Reactome: R-HSA-70171;KEGG: 00051+2.7.1.11;KEGG: 00030+2.7.1.11;MetaCyc: PWY-1861;MetaCyc: PWY-7385;MetaCyc: PWY-1042;MetaCyc: PWY-5484;KEGG: 00680+2.7.1.11;KEGG: 00052+2.7.1.11;KEGG: 00010+2.7.1.11 "Glycolysis";"Fructose and mannose metabolism";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"1,3-propanediol biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism";"Galactose metabolism";"Glycolysis / Gluconeogenesis" XP_046737392.1 2 Reactome: R-HSA-5250971;Reactome: R-HSA-5682910 "Toxicity of botulinum toxin type C (BoNT/C)";"LGI-ADAM interactions" XP_046741769.1 2 Reactome: R-HSA-163841;KEGG: 00900+2.1.1.100 "Gamma carboxylation, hypusine formation and arylsulfatase activation";"Terpenoid backbone biosynthesis" XP_046750380.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046750406.1 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" XP_046752384.1 3 Reactome: R-HSA-3899300;Reactome: R-HSA-3232118;Reactome: R-HSA-4090294 "SUMOylation of transcription cofactors";"SUMOylation of transcription factors";"SUMOylation of intracellular receptors" XP_046745849.1 2 MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Glycerol degradation I";"Glycerolipid metabolism" XP_046737287.1 7 Reactome: R-HSA-2979096;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;MetaCyc: PWY-7511;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232 "NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants" XP_046747531.1 3 Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-936837 "Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Ion transport by P-type ATPases" XP_046738908.1 2 Reactome: R-HSA-380095;Reactome: R-HSA-416476 "Tachykinin receptors bind tachykinins";"G alpha (q) signalling events" XP_046748176.1 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" XP_046734012.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" XP_046744185.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046734740.1 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" XP_046752050.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046751769.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046749755.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046740826.1 3 KEGG: 00860+2.5.1.141;Reactome: R-HSA-189451;MetaCyc: PWY-7856 "Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Heme a biosynthesis" XP_046749903.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046741642.1 1 Reactome: R-HSA-6811438 "Intra-Golgi traffic" XP_046748319.1 27 Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-159227 "Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"HCMV Late Events";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"snRNP Assembly";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA" XP_046739805.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046735463.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" XP_046741960.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046745864.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046745632.1 11 Reactome: R-HSA-5610787;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-170670;Reactome: R-HSA-418555;Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-163615 "Hedgehog 'off' state";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"Adenylate cyclase inhibitory pathway";"G alpha (s) signalling events";"Adenylate cyclase activating pathway";"Purine metabolism";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"G alpha (z) signalling events";"PKA activation" XP_046751566.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046753361.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046734438.1 3 MetaCyc: PWY-6689;MetaCyc: PWY-7803;Reactome: R-HSA-6784531 "Trna splicing I";"Trna splicing II";"tRNA processing in the nucleus" XP_046753310.1 3 Reactome: R-HSA-418457;Reactome: R-HSA-392517;Reactome: R-HSA-4086398 "cGMP effects";"Rap1 signalling";"Ca2+ pathway" XP_046747912.1 26 Reactome: R-HSA-933541;Reactome: R-HSA-210744;Reactome: R-HSA-8941856;Reactome: R-HSA-3134973;Reactome: R-HSA-8866907;Reactome: R-HSA-9617629;Reactome: R-HSA-3371568;Reactome: R-HSA-2894862;Reactome: R-HSA-1912408;Reactome: R-HSA-201722;Reactome: R-HSA-2644606;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-5617472;Reactome: R-HSA-9013695;Reactome: R-HSA-9013508;Reactome: R-HSA-5621575;Reactome: R-HSA-9614657;Reactome: R-HSA-2122947;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-918233;Reactome: R-HSA-1234158;Reactome: R-HSA-3214847;Reactome: R-HSA-3899300;Reactome: R-HSA-1368082 "TRAF6 mediated IRF7 activation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"RUNX3 regulates NOTCH signaling";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Activation of the TFAP2 (AP-2) family of transcription factors";"Regulation of FOXO transcriptional activity by acetylation";"Attenuation phase";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"Formation of the beta-catenin:TCF transactivating complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"PPARA activates gene expression";"Estrogen-dependent gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH3 Intracellular Domain Regulates Transcription";"CD209 (DC-SIGN) signaling";"FOXO-mediated transcription of cell death genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"TRAF3-dependent IRF activation pathway";"Regulation of gene expression by Hypoxia-inducible Factor";"HATs acetylate histones";"SUMOylation of transcription cofactors";"RORA activates gene expression" XP_046745121.1 1 Reactome: R-HSA-429958 "mRNA decay by 3' to 5' exoribonuclease" XP_046735849.1 8 Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-174430;Reactome: R-HSA-113501;Reactome: R-HSA-69091;Reactome: R-HSA-69166;Reactome: R-HSA-69183;Reactome: R-HSA-68952 "Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand synthesis initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Polymerase switching";"Removal of the Flap Intermediate";"Processive synthesis on the lagging strand";"DNA replication initiation" XP_046751395.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046750814.1 4 Reactome: R-HSA-5205685;Reactome: R-HSA-8934903;Reactome: R-HSA-936440;Reactome: R-HSA-1632852 "Pink/Parkin Mediated Mitophagy";"Receptor Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling";"Macroautophagy" XP_046745298.1 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" XP_046737110.1 2 Reactome: R-HSA-6783310;Reactome: R-HSA-5693568 "Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates" XP_046746533.1 2 Reactome: R-HSA-8854518;Reactome: R-HSA-6804756 "AURKA Activation by TPX2";"Regulation of TP53 Activity through Phosphorylation" XP_046739512.1 2 Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" XP_046752234.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046743842.1 1 Reactome: R-HSA-2299718 "Condensation of Prophase Chromosomes" XP_046739657.1 3 Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-8963901 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Chylomicron remodeling" XP_046742395.1 7 KEGG: 00564+3.1.4.4;MetaCyc: PWY-3561;KEGG: 00565+3.1.4.4;Reactome: R-HSA-1483166;Reactome: R-HSA-2029485;Reactome: R-HSA-1483148;MetaCyc: PWY-7039 "Glycerophospholipid metabolism";"Choline biosynthesis III";"Ether lipid metabolism";"Synthesis of PA";"Role of phospholipids in phagocytosis";"Synthesis of PG";"Phosphatidate metabolism, as a signaling molecule" XP_046741678.1 2 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.21 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046743392.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-8866654 "Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046742718.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046750924.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046752504.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046742796.1 1 Reactome: R-HSA-201681 "TCF dependent signaling in response to WNT" XP_046752912.1 1 Reactome: R-HSA-6806664 "Metabolism of vitamin K" XP_046746211.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046751262.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046747992.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046753201.1 4 MetaCyc: PWY-3722;Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-7494 "Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline catabolism";"Glycine, serine and threonine metabolism";"Choline degradation IV" XP_046747005.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046752157.1 3 Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-191859 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"snRNP Assembly" XP_046736428.1 2 Reactome: R-HSA-8854518;Reactome: R-HSA-6804756 "AURKA Activation by TPX2";"Regulation of TP53 Activity through Phosphorylation" XP_046747333.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046747317.1 26 Reactome: R-HSA-9646399;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-380320;Reactome: R-HSA-437239;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-389960;Reactome: R-HSA-9648025;Reactome: R-HSA-389977;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434 "Aggrephagy";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport";"Kinesins";"Recruitment of NuMA to mitotic centrosomes";"Recycling pathway of L1";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"Cilium Assembly";"Separation of Sister Chromatids";"Formation of tubulin folding intermediates by CCT/TriC";"EML4 and NUDC in mitotic spindle formation";"Post-chaperonin tubulin folding pathway";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"RHO GTPases activate IQGAPs";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046745521.1 4 KEGG: 00480+1.1.1.49;KEGG: 00030+1.1.1.49;MetaCyc: PWY-8004;MetaCyc: PWY-7268 "Glutathione metabolism";"Pentose phosphate pathway";"Entner-Doudoroff pathway I";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)" XP_046750449.1 2 Reactome: R-HSA-6787450;Reactome: R-HSA-6782315 "tRNA modification in the mitochondrion";"tRNA modification in the nucleus and cytosol" XP_046736496.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046740161.1 2 Reactome: R-HSA-8866904;Reactome: R-HSA-8866907 "Negative regulation of activity of TFAP2 (AP-2) family transcription factors";"Activation of the TFAP2 (AP-2) family of transcription factors" XP_046737834.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046751446.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046742247.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046745267.1 1 Reactome: R-HSA-9018519 "Estrogen-dependent gene expression" XP_046740115.1 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" XP_046749293.1 5 Reactome: R-HSA-5218921;Reactome: R-HSA-186763;Reactome: R-HSA-3928662;Reactome: R-HSA-5658442;Reactome: R-HSA-8849471 "VEGFR2 mediated cell proliferation";"Downstream signal transduction";"EPHB-mediated forward signaling";"Regulation of RAS by GAPs";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" XP_046752876.1 1 Reactome: R-HSA-1362409 "Mitochondrial iron-sulfur cluster biogenesis" XP_046744433.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046750464.1 1 Reactome: R-HSA-8953750 "Transcriptional Regulation by E2F6" XP_046747719.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046742045.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884 "Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I" XP_046741260.1 3 MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2 "Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism" XP_046751028.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046749157.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046743527.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046744769.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046742082.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046738521.1 2 Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58 "Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis" XP_046737039.1 16 Reactome: R-HSA-174048;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-176412;Reactome: R-HSA-176408;Reactome: R-HSA-176409;Reactome: R-HSA-174184;Reactome: R-HSA-176407;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-179409;Reactome: R-HSA-174084 "APC/C:Cdc20 mediated degradation of Cyclin B";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Phosphorylation of the APC/C";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC-Cdc20 mediated degradation of Nek2A";"Autodegradation of Cdh1 by Cdh1:APC/C" XP_046746375.1 19 Reactome: R-HSA-202733;Reactome: R-HSA-975634;Reactome: R-HSA-8964038;Reactome: R-HSA-8957275;Reactome: R-HSA-8964026;Reactome: R-HSA-8964041;Reactome: R-HSA-3000471;Reactome: R-HSA-5686938;Reactome: R-HSA-3000484;Reactome: R-HSA-8964046;Reactome: R-HSA-8963901;Reactome: R-HSA-3000480;Reactome: R-HSA-8963888;Reactome: R-HSA-3000497;Reactome: R-HSA-8856825;Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-381426;Reactome: R-HSA-8856828 "Cell surface interactions at the vascular wall";"Retinoid metabolism and transport";"LDL clearance";"Post-translational protein phosphorylation";"Chylomicron clearance";"LDL remodeling";"Scavenging by Class B Receptors";"Regulation of TLR by endogenous ligand";"Scavenging by Class F Receptors";"VLDL clearance";"Chylomicron remodeling";"Scavenging by Class A Receptors";"Chylomicron assembly";"Scavenging by Class H Receptors";"Cargo recognition for clathrin-mediated endocytosis";"Platelet sensitization by LDL";"VLDL assembly";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Clathrin-mediated endocytosis" XP_046737394.1 2 Reactome: R-HSA-5682910;Reactome: R-HSA-5250971 "LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)" XP_046734867.1 7 MetaCyc: PWY-7158;KEGG: 00360+1.14.16.1;Reactome: R-HSA-2160456;Reactome: R-HSA-8964208;KEGG: 00790+1.14.16.1;KEGG: 00400+1.14.16.1;MetaCyc: PWY-6134 "L-phenylalanine degradation V";"Phenylalanine metabolism";"Phenylketonuria";"Phenylalanine metabolism";"Folate biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"L-tyrosine biosynthesis IV" XP_046744830.1 7 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" XP_046736863.1 2 Reactome: R-HSA-168276;Reactome: R-HSA-1169408 "NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism" XP_046749040.1 9 Reactome: R-HSA-1855204;Reactome: R-HSA-112043;Reactome: R-HSA-416476;MetaCyc: PWY-6367;MetaCyc: PWY-8052;MetaCyc: PWY-7039;MetaCyc: PWY-6351;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11 "Synthesis of IP3 and IP4 in the cytosol";"PLC beta mediated events";"G alpha (q) signalling events";"D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system" XP_046744941.1 4 Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-1912420 "Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi" XP_046735975.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046735216.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046734331.1 4 Reactome: R-HSA-5689880;Reactome: R-HSA-418594;Reactome: R-HSA-201681;Reactome: R-HSA-4641257 "Ub-specific processing proteases";"G alpha (i) signalling events";"TCF dependent signaling in response to WNT";"Degradation of AXIN" XP_046741168.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046745232.1 2 Reactome: R-HSA-9610379;Reactome: R-HSA-917729 "HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)" XP_046743686.1 19 Reactome: R-HSA-114604;Reactome: R-HSA-5663213;Reactome: R-HSA-5687128;Reactome: R-HSA-5625970;Reactome: R-HSA-182971;Reactome: R-HSA-194840;Reactome: R-HSA-8964616;Reactome: R-HSA-5626467;Reactome: R-HSA-428543;Reactome: R-HSA-389359;Reactome: R-HSA-5627123;Reactome: R-HSA-418885;Reactome: R-HSA-983231;Reactome: R-HSA-4420097;Reactome: R-HSA-5663220;Reactome: R-HSA-525793;Reactome: R-HSA-8950505;Reactome: R-HSA-2029482;Reactome: R-HSA-3928662 "GPVI-mediated activation cascade";"RHO GTPases Activate WASPs and WAVEs";"MAPK6/MAPK4 signaling";"RHO GTPases activate KTN1";"EGFR downregulation";"Rho GTPase cycle";"G beta:gamma signalling through CDC42";"RHO GTPases activate IQGAPs";"Inactivation of CDC42 and RAC1";"CD28 dependent Vav1 pathway";"RHO GTPases activate PAKs";"DCC mediated attractive signaling";"Factors involved in megakaryocyte development and platelet production";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate Formins";"Myogenesis";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling" XP_046750466.1 8 Reactome: R-HSA-9633012;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046746268.1 3 MetaCyc: PWY-7159;KEGG: 00860+1.3.3.3;Reactome: R-HSA-189451 "3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis" XP_046741298.1 1 Reactome: R-HSA-1483148 "Synthesis of PG" XP_046746736.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046746097.1 10 MetaCyc: PWY-6362;Reactome: R-HSA-1855191;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6369;KEGG: 04070+2.7.1.158;MetaCyc: PWY-4661;MetaCyc: PWY-6361;MetaCyc: PWY-6554;MetaCyc: PWY-6372;Reactome: R-HSA-1855167 "1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Synthesis of IPs in the nucleus";"Inositol phosphate metabolism";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of pyrophosphates in the cytosol" XP_046742382.1 2 Reactome: R-HSA-983231;Reactome: R-HSA-383280 "Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway" XP_046739591.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046748242.1 1 Reactome: R-HSA-389661 "Glyoxylate metabolism and glycine degradation" XP_046750120.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046740278.1 5 Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" XP_046742271.1 1 Reactome: R-HSA-428359 "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" XP_046744536.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046752764.1 1 Reactome: R-HSA-193648 "NRAGE signals death through JNK" XP_046740244.1 2 Reactome: R-HSA-162710;KEGG: 00563+3.5.1.89 "Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis" XP_046744193.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046748746.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046734592.1 16 Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553 "Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" XP_046745172.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046739584.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046753600.1 4 Reactome: R-HSA-73621;KEGG: 00910+1.4.1.14;KEGG: 00250+1.4.1.14;MetaCyc: PWY-6963 "Pyrimidine catabolism";"Nitrogen metabolism";"Alanine, aspartate and glutamate metabolism";"Ammonia assimilation cycle I" XP_046753833.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046748568.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046746913.1 1 Reactome: R-HSA-977225 "Amyloid fiber formation" XP_046751687.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" XP_046742831.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046735435.1 42 MetaCyc: PWY-5109;KEGG: 00592+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6945;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-6863;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;KEGG: 00903+4.2.1.17;KEGG: 00640+4.2.1.17;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;MetaCyc: PWY-5136;KEGG: 00360+4.2.1.17;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-7401;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-6944;MetaCyc: PWY-7094;KEGG: 00623+1.1.1.35;MetaCyc: PWY-7216;MetaCyc: PWY-1361;MetaCyc: PWY-5789;MetaCyc: PWY-6883;MetaCyc: PWY-7726;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-5138;MetaCyc: PWY-7007;MetaCyc: PWY-7606;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-7654;MetaCyc: PWY-7779;KEGG: 00410+4.2.1.17;MetaCyc: PWY-6583;KEGG: 00280+4.2.1.17+1.1.1.35 "Fermentation to 2-methylbutanoate";"alpha-Linolenic acid metabolism";"Butanoate metabolism";"Aminobenzoate degradation";"Caprolactam degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Fatty acid degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Fatty acid degradation";"2-methylpropene degradation";"Pyruvate fermentation to hexanol (engineered)";"Benzoate degradation";"Glutaryl-coa degradation";"Limonene and pinene degradation";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Tryptophan metabolism";"Spodoptera littoralis pheromone biosynthesis";"Fatty acid beta-oxidation II (plant peroxisome)";"Phenylalanine metabolism";"Lysine degradation";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Geraniol degradation";"Androstenedione degradation";"Fatty acid salvage";"Toluene degradation";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Benzoyl-coa degradation I (aerobic)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Pyruvate fermentation to butanol II (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid elongation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Butanoate metabolism";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Methyl tert-butyl ether degradation";"beta-Alanine metabolism";"Pyruvate fermentation to butanol I";"Valine, leucine and isoleucine degradation" XP_046741415.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046742783.1 2 Reactome: R-HSA-6783984;KEGG: 00260+1.4.4.2 "Glycine degradation";"Glycine, serine and threonine metabolism" XP_046744298.1 12 Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2467813 "COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Separation of Sister Chromatids" XP_046735678.1 1 Reactome: R-HSA-204626 "Hypusine synthesis from eIF5A-lysine" XP_046743342.1 5 KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00380+1.2.4.2;Reactome: R-HSA-389661;MetaCyc: PWY-5084 "Lysine degradation";"Citrate cycle (TCA cycle)";"Tryptophan metabolism";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA" XP_046748867.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046737374.1 1 Reactome: R-HSA-110362 "POLB-Dependent Long Patch Base Excision Repair" XP_046747026.1 11 Reactome: R-HSA-450302;Reactome: R-HSA-171007;KEGG: 05165+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 04926+2.7.11.1;Reactome: R-HSA-2559580;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "activated TAK1 mediates p38 MAPK activation";"p38MAPK events";"Human papillomavirus infection";"VEGFA-VEGFR2 Pathway";"Relaxin signaling pathway";"Oxidative Stress Induced Senescence";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046742008.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046741056.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046752069.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046753527.1 16 Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-72689 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits" XP_046752156.1 3 Reactome: R-HSA-191859;Reactome: R-HSA-72165;Reactome: R-HSA-72163 "snRNP Assembly";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" XP_046753422.1 5 Reactome: R-HSA-196807;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;MetaCyc: PWY-5083 "Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation" XP_046753313.1 2 Reactome: R-HSA-4086398;Reactome: R-HSA-418457 "Ca2+ pathway";"cGMP effects" XP_046734780.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046739322.1 5 Reactome: R-HSA-5685938;Reactome: R-HSA-5696395;Reactome: R-HSA-6783310;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400 "HDR through Single Strand Annealing (SSA)";"Formation of Incision Complex in GG-NER";"Fanconi Anemia Pathway";"Dual incision in TC-NER";"Dual Incision in GG-NER" XP_046744280.1 12 Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878 "Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport" XP_046738128.1 2 Reactome: R-HSA-202733;Reactome: R-HSA-416993 "Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors" XP_046751185.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046751022.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046742009.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046748033.1 1 Reactome: R-HSA-1660499 "Synthesis of PIPs at the plasma membrane" XP_046735607.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046747430.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046747892.1 10 Reactome: R-HSA-8941856;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-2197563;Reactome: R-HSA-9013508;Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-2894862 "RUNX3 regulates NOTCH signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants" XP_046746444.1 7 Reactome: R-HSA-5083633;Reactome: R-HSA-3000171;Reactome: R-HSA-5083629;Reactome: R-HSA-5083628;Reactome: R-HSA-5173105;Reactome: R-HSA-9010553;Reactome: R-HSA-3000178 "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Non-integrin membrane-ECM interactions";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"O-linked glycosylation";"Regulation of expression of SLITs and ROBOs";"ECM proteoglycans" XP_046751577.1 1 Reactome: R-HSA-211981 "Xenobiotics" XP_046737351.1 4 Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823 "Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex" XP_046733912.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046752251.1 3 MetaCyc: PWY-7420;Reactome: R-HSA-426048;KEGG: 00561+3.1.1.23 "Monoacylglycerol metabolism (yeast)";"Arachidonate production from DAG";"Glycerolipid metabolism" XP_046743758.1 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" XP_046744486.1 7 Reactome: R-HSA-141444;Reactome: R-HSA-606279;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Deposition of new CENPA-containing nucleosomes at the centromere";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids" XP_046752151.1 9 MetaCyc: PWY-6147;MetaCyc: PWY-7442;MetaCyc: PWY-6703;Reactome: R-HSA-1474151;MetaCyc: PWY-5663;MetaCyc: PWY-5664;MetaCyc: PWY-7852;MetaCyc: PWY-6983;KEGG: 00790+3.5.4.16 "6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Drosopterin and aurodrosopterin biosynthesis";"Preq0 biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis I";"Erythro-tetrahydrobiopterin biosynthesis II";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Threo-tetrahydrobiopterin biosynthesis";"Folate biosynthesis" XP_046738378.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046746123.1 3 Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400 "Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Dual Incision in GG-NER" XP_046737713.1 5 Reactome: R-HSA-427413;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-73772 "NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Promoter Escape" XP_046744488.1 7 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-606279;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Deposition of new CENPA-containing nucleosomes at the centromere";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046744775.1 8 Reactome: R-HSA-9639288;Reactome: R-HSA-3371571;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-8943724;Reactome: R-HSA-165159 "Amino acids regulate mTORC1";"HSF1-dependent transactivation";"Macroautophagy";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Regulation of PTEN gene transcription";"mTOR signalling" XP_046744016.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046751003.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046748736.1 1 Reactome: R-HSA-9603798 "Class I peroxisomal membrane protein import" XP_046735723.1 7 Reactome: R-HSA-5628897;KEGG: 00220+3.5.1.2;MetaCyc: PWY-5921;Reactome: R-HSA-8964539;KEGG: 00250+3.5.1.2;Reactome: R-HSA-210500;KEGG: 00471+3.5.1.2 "TP53 Regulates Metabolic Genes";"Arginine biosynthesis";"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate and glutamine metabolism";"Alanine, aspartate and glutamate metabolism";"Glutamate Neurotransmitter Release Cycle";"D-Glutamine and D-glutamate metabolism" XP_046736273.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046734313.1 16 Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-8936459;Reactome: R-HSA-8853884;Reactome: R-HSA-4086398;Reactome: R-HSA-2559585;Reactome: R-HSA-426496;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723 "Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by VENTX";"Ca2+ pathway";"Oncogene Induced Senescence";"Post-transcriptional silencing by small RNAs";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation" XP_046749546.1 5 Reactome: R-HSA-5693571;Reactome: R-HSA-5693607;Reactome: R-HSA-3232118;Reactome: R-HSA-69473;Reactome: R-HSA-5693565 "Nonhomologous End-Joining (NHEJ)";"Processing of DNA double-strand break ends";"SUMOylation of transcription factors";"G2/M DNA damage checkpoint";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" XP_046752767.1 2 Reactome: R-HSA-5635838;Reactome: R-HSA-5632681 "Activation of SMO";"Ligand-receptor interactions" XP_046735279.1 1 KEGG: 00970+6.1.1.9 "Aminoacyl-tRNA biosynthesis" XP_046750471.1 4 Reactome: R-HSA-2173788;Reactome: R-HSA-3656532;Reactome: R-HSA-3304356;Reactome: R-HSA-2173789 "Downregulation of TGF-beta receptor signaling";"TGFBR1 KD Mutants in Cancer";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGF-beta receptor signaling activates SMADs" XP_046733868.1 4 Reactome: R-HSA-1855183;MetaCyc: PWY-4841;KEGG: 00562+1.13.99.1;KEGG: 00053+1.13.99.1 "Synthesis of IP2, IP, and Ins in the cytosol";"UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)";"Inositol phosphate metabolism";"Ascorbate and aldarate metabolism" XP_046734626.1 31 MetaCyc: PWY-7664;MetaCyc: PWY-5971;Reactome: R-HSA-75105;MetaCyc: PWY-6113;MetaCyc: PWY-7663;MetaCyc: PWY-5142;MetaCyc: PWY-8047;MetaCyc: PWY-6519;MetaCyc: PWY-5989;MetaCyc: PWYG-321;MetaCyc: PWY-6282;MetaCyc: PWY-5966-1;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-6799;MetaCyc: PWY-4381;MetaCyc: PWY-5973;MetaCyc: PWY-5367;MetaCyc: PWY-7388;MetaCyc: PWY-8049;Reactome: R-HSA-199220;Reactome: R-HSA-9029558;MetaCyc: PWY-8012;MetaCyc: PWY-5994;MetaCyc: PWY-7723;MetaCyc: PWY-7746;MetaCyc: PWY-5366;Reactome: R-HSA-163765;Reactome: R-HSA-2426168;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5147;MetaCyc: PWY-7858 "Oleate biosynthesis IV (anaerobic)";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Fatty acyl-CoA biosynthesis";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Bryostatin biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Stearate biosynthesis II (bacteria and plants)";"";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Cis-vaccenate biosynthesis";"Petroselinate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Pederin biosynthesis";"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Mupirocin biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Bacterial bioluminescence";"Mycobacterial sulfolipid biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)";"Biotin metabolism";"Oleate biosynthesis I (plants)";"(5Z)-dodecenoate biosynthesis II" XP_046737417.1 3 Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-9018519 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression" XP_046749237.1 2 Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" XP_046753519.1 4 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541;Reactome: R-HSA-499943 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Abacavir metabolism";"Interconversion of nucleotide di- and triphosphates" XP_046744312.1 12 Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025 "HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation" XP_046735930.1 6 KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7039;MetaCyc: PWY-7817 "Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046752336.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046735284.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046745091.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046745835.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046743486.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046736631.1 9 Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-68867;Reactome: R-HSA-69017;Reactome: R-HSA-68827;Reactome: R-HSA-68962;Reactome: R-HSA-68689 "Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Assembly of the pre-replicative complex";"CDK-mediated phosphorylation and removal of Cdc6";"CDT1 association with the CDC6:ORC:origin complex";"Activation of the pre-replicative complex";"CDC6 association with the ORC:origin complex" XP_046736123.1 3 KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway" XP_046746839.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046746835.1 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" XP_046739829.1 6 Reactome: R-HSA-5620922;Reactome: R-HSA-6814122;Reactome: R-HSA-389957;Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-390450 "BBSome-mediated cargo-targeting to cilium";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC" XP_046746734.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046745415.1 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" XP_046745897.1 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" XP_046753936.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046734815.1 2 Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46 "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism" XP_046747089.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" XP_046735720.1 7 Reactome: R-HSA-5628897;KEGG: 00220+3.5.1.2;Reactome: R-HSA-8964539;MetaCyc: PWY-5921;Reactome: R-HSA-210500;KEGG: 00471+3.5.1.2;KEGG: 00250+3.5.1.2 "TP53 Regulates Metabolic Genes";"Arginine biosynthesis";"Glutamate and glutamine metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate Neurotransmitter Release Cycle";"D-Glutamine and D-glutamate metabolism";"Alanine, aspartate and glutamate metabolism" XP_046737361.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046740052.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046746465.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046735564.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046739065.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046748648.1 42 KEGG: 00640+4.2.1.17;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6946;MetaCyc: PWY-5136;MetaCyc: PWY-7656;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;MetaCyc: PWY-6435;MetaCyc: PWY-7778;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-6863;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6945;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-5109;KEGG: 00592+4.2.1.17;MetaCyc: PWY-7007;MetaCyc: PWY-7606;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00410+4.2.1.17;MetaCyc: PWY-6583;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;MetaCyc: PWY-7654;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-5138;MetaCyc: PWY-7094;MetaCyc: PWY-6944;KEGG: 00623+1.1.1.35;MetaCyc: PWY-7216;MetaCyc: PWY-7726;MetaCyc: PWY-6883;MetaCyc: PWY-5789;MetaCyc: PWY-1361;MetaCyc: PWY-7401;KEGG: 00281+4.2.1.17+1.1.1.35 "Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Glutaryl-coa degradation";"Benzoate degradation";"Limonene and pinene degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Fatty acid beta-oxidation II (plant peroxisome)";"Spodoptera littoralis pheromone biosynthesis";"Tryptophan metabolism";"Lysine degradation";"Phenylalanine metabolism";"4-hydroxybenzoate biosynthesis III (plants)";"2-methylpropene degradation";"Fatty acid degradation";"Pyruvate fermentation to hexanol (engineered)";"Butanoate metabolism";"Aminobenzoate degradation";"Caprolactam degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Fatty acid degradation";"Fermentation to 2-methylbutanoate";"alpha-Linolenic acid metabolism";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Butanoate metabolism";"beta-Alanine metabolism";"Pyruvate fermentation to butanol I";"Valine, leucine and isoleucine degradation";"Methyl tert-butyl ether degradation";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Fatty acid elongation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Fatty acid salvage";"Androstenedione degradation";"Toluene degradation";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Pyruvate fermentation to butanol II (engineered)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Benzoyl-coa degradation I (aerobic)";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Geraniol degradation" XP_046740562.1 7 Reactome: R-HSA-8950505;Reactome: R-HSA-389957;Reactome: R-HSA-6814122;Reactome: R-HSA-5620922;Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-390471 "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"BBSome-mediated cargo-targeting to cilium";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis" XP_046753205.1 19 Reactome: R-HSA-9022692;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-111932;Reactome: R-HSA-9620244;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-438066;Reactome: R-HSA-399719;Reactome: R-HSA-442982 "Regulation of MECP2 expression and activity";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"CaMK IV-mediated phosphorylation of CREB";"Long-term potentiation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Unblocking of NMDA receptors, glutamate binding and activation";"Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor" XP_046741394.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-7656;MetaCyc: PWY-6733;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782 "Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis" XP_046746652.1 7 KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046741001.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046753311.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-4086398 "cGMP effects";"Ca2+ pathway" XP_046740390.1 4 MetaCyc: PWY-7887;KEGG: 00790+2.8.1.12;MetaCyc: PWY-6823;Reactome: R-HSA-947581 "Protein SAMPylation and SAMP-mediated thiolation";"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis" XP_046745279.1 5 Reactome: R-HSA-936964;Reactome: R-HSA-937041;Reactome: R-HSA-166166;Reactome: R-HSA-937072;Reactome: R-HSA-168164 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1";"MyD88-independent TLR4 cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Toll Like Receptor 3 (TLR3) Cascade" XP_046735984.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046741185.1 2 Reactome: R-HSA-983168;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation" XP_046746069.1 15 Reactome: R-HSA-5637810;Reactome: R-HSA-9665244;Reactome: R-HSA-1236382;Reactome: R-HSA-9652282;Reactome: R-HSA-8863795;Reactome: R-HSA-9665233;Reactome: R-HSA-9665247;Reactome: R-HSA-9665251;Reactome: R-HSA-9665250;Reactome: R-HSA-9664565;Reactome: R-HSA-9634285;Reactome: R-HSA-9665245;Reactome: R-HSA-9665246;Reactome: R-HSA-9665249;Reactome: R-HSA-1227986 "Constitutive Signaling by EGFRvIII";"Resistance of ERBB2 KD mutants to sapitinib";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Drug-mediated inhibition of ERBB2 signaling";"Downregulation of ERBB2 signaling";"Resistance of ERBB2 KD mutants to trastuzumab";"Resistance of ERBB2 KD mutants to osimertinib";"Resistance of ERBB2 KD mutants to lapatinib";"Resistance of ERBB2 KD mutants to AEE788";"Signaling by ERBB2 KD Mutants";"Constitutive Signaling by Overexpressed ERBB2";"Resistance of ERBB2 KD mutants to tesevatinib";"Resistance of ERBB2 KD mutants to neratinib";"Resistance of ERBB2 KD mutants to afatinib";"Signaling by ERBB2" XP_046744188.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046752736.1 1 Reactome: R-HSA-8876725 "Protein methylation" XP_046748080.1 13 Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226 "Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046744227.1 4 Reactome: R-HSA-2214320;Reactome: R-HSA-1650814;Reactome: R-HSA-2243919;Reactome: R-HSA-1474228 "Anchoring fibril formation";"Collagen biosynthesis and modifying enzymes";"Crosslinking of collagen fibrils";"Degradation of the extracellular matrix" XP_046735314.1 1 Reactome: R-HSA-432722 "Golgi Associated Vesicle Biogenesis" XP_046739559.1 2 Reactome: R-HSA-983168;Reactome: R-HSA-6798695 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation" XP_046747013.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046736889.1 1 KEGG: 00970+6.1.1.20 "Aminoacyl-tRNA biosynthesis" XP_046739560.1 2 Reactome: R-HSA-983168;Reactome: R-HSA-6798695 "Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation" XP_046737753.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046741156.1 6 Reactome: R-HSA-418597;Reactome: R-HSA-114516;Reactome: R-HSA-416993;KEGG: 04070+2.7.11.13;Reactome: R-HSA-5099900;Reactome: R-HSA-76005 "G alpha (z) signalling events";"Disinhibition of SNARE formation";"Trafficking of GluR2-containing AMPA receptors";"Phosphatidylinositol signaling system";"WNT5A-dependent internalization of FZD4";"Response to elevated platelet cytosolic Ca2+" XP_046736326.1 2 Reactome: R-HSA-1483148;Reactome: R-HSA-1483166 "Synthesis of PG";"Synthesis of PA" XP_046753975.1 9 Reactome: R-HSA-1368108;Reactome: R-HSA-1368082;Reactome: R-HSA-2151201;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-5617472;Reactome: R-HSA-400206 "BMAL1:CLOCK,NPAS2 activates circadian gene expression";"RORA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of lipid metabolism by PPARalpha" XP_046741993.1 2 Reactome: R-HSA-2408522;Reactome: R-HSA-379716 "Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation" XP_046745231.1 2 Reactome: R-HSA-1482798;Reactome: R-HSA-1268020 "Acyl chain remodeling of CL";"Mitochondrial protein import" XP_046753787.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046747891.1 10 Reactome: R-HSA-2122947;Reactome: R-HSA-8941856;Reactome: R-HSA-210744;Reactome: R-HSA-9013508;Reactome: R-HSA-2197563;Reactome: R-HSA-9013695;Reactome: R-HSA-2644606;Reactome: R-HSA-1912408;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "NOTCH1 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" XP_046736971.1 3 Reactome: R-HSA-6790901;Reactome: R-HSA-8951664;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Neddylation";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046733996.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046749759.1 1 Reactome: R-HSA-3108214 "SUMOylation of DNA damage response and repair proteins" XP_046752988.1 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" XP_046750667.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046744028.1 4 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"DARPP-32 events";"Th1 and Th2 cell differentiation" XP_046742435.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046739585.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046748092.1 3 Reactome: R-HSA-6783984;KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine degradation";"Glycine, serine and threonine metabolism";"One carbon pool by folate" XP_046753816.1 5 Reactome: R-HSA-450321;Reactome: R-HSA-2559580;Reactome: R-HSA-2871796;Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation";"Activation of the AP-1 family of transcription factors";"mTOR signaling pathway" XP_046748175.1 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" XP_046745309.1 2 Reactome: R-HSA-5689896;Reactome: R-HSA-936440 "Ovarian tumor domain proteases";"Negative regulators of DDX58/IFIH1 signaling" XP_046749376.1 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" XP_046753419.1 2 Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46 "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism" XP_046750561.1 9 Reactome: R-HSA-9630221;Reactome: R-HSA-9608287;Reactome: R-HSA-110328;Reactome: R-HSA-9630222;Reactome: R-HSA-110330;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-9608290;Reactome: R-HSA-110357 "Defective NTHL1 substrate processing";"Defective MUTYH substrate binding";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective NTHL1 substrate binding";"Recognition and association of DNA glycosylase with site containing an affected purine";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Defective MUTYH substrate processing";"Displacement of DNA glycosylase by APEX1" XP_046744577.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046738675.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046751713.1 8 Reactome: R-HSA-5617472;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-8943724;Reactome: R-HSA-8953750;Reactome: R-HSA-3214841;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690 "Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Regulation of PTEN gene transcription";"Transcriptional Regulation by E2F6";"PKMTs methylate histone lysines";"SUMOylation of chromatin organization proteins";"HCMV Early Events" XP_046747544.1 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" XP_046744043.1 4 Reactome: R-HSA-5603037;Reactome: R-HSA-975871;Reactome: R-HSA-5602680;Reactome: R-HSA-168176 "IRAK4 deficiency (TLR5)";"MyD88 cascade initiated on plasma membrane";"MyD88 deficiency (TLR5)";"Toll Like Receptor 5 (TLR5) Cascade" XP_046747486.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046743955.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046746684.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046748220.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046754046.1 2 Reactome: R-HSA-2132295;Reactome: R-HSA-877300 "MHC class II antigen presentation";"Interferon gamma signaling" XP_046749295.1 5 Reactome: R-HSA-8856828;Reactome: R-HSA-182971;Reactome: R-HSA-8856825;Reactome: R-HSA-8875360;Reactome: R-HSA-6807004 "Clathrin-mediated endocytosis";"EGFR downregulation";"Cargo recognition for clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Negative regulation of MET activity" XP_046744586.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046751393.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046746098.1 10 Reactome: R-HSA-1855191;MetaCyc: PWY-6362;MetaCyc: PWY-6369;KEGG: 04070+2.7.1.158;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6372;Reactome: R-HSA-1855167;MetaCyc: PWY-6361;MetaCyc: PWY-4661;MetaCyc: PWY-6554 "Synthesis of IPs in the nucleus";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)" XP_046747637.1 4 Reactome: R-HSA-381771;Reactome: R-HSA-400511;Reactome: R-HSA-422085;Reactome: R-HSA-1799339 "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin";"SRP-dependent cotranslational protein targeting to membrane" XP_046748992.1 4 Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-6807878;Reactome: R-HSA-445095 "RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins" XP_046751224.1 5 Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-381183;Reactome: R-HSA-9614657;Reactome: R-HSA-380994 "PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"ATF6 (ATF6-alpha) activates chaperone genes";"FOXO-mediated transcription of cell death genes";"ATF4 activates genes in response to endoplasmic reticulum stress" XP_046737917.1 2 Reactome: R-HSA-1268020;Reactome: R-HSA-71403 "Mitochondrial protein import";"Citric acid cycle (TCA cycle)" XP_046749598.1 13 Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-6791226 "Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046740765.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046750939.1 5 Reactome: R-HSA-6798695;KEGG: 00230+3.6.1.6;KEGG: 00240+3.6.1.6;MetaCyc: PWY-7185;MetaCyc: PWY-7210 "Neutrophil degranulation";"Purine metabolism";"Pyrimidine metabolism";"UTP and CTP dephosphorylation I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP" XP_046751447.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046738456.1 2 Reactome: R-HSA-9603798;Reactome: R-HSA-1369062 "Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis" XP_046738834.1 14 MetaCyc: PWY-7417;MetaCyc: PWY-7416;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00591+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-7783;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00590+3.1.1.4 "Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism";"Retinoid metabolism and transport";"Linoleic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Plasmalogen degradation";"Glycerophospholipid metabolism";"Arachidonic acid metabolism" XP_046736754.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046748758.1 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" XP_046749842.1 2 Reactome: R-HSA-6783310;Reactome: R-HSA-5693568 "Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates" XP_046739373.1 12 Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-451308;Reactome: R-HSA-438066;KEGG: 00230+2.7.4.8;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-8849932;Reactome: R-HSA-447038;MetaCyc: PWY-7221;Reactome: R-HSA-399719;Reactome: R-HSA-9620244 "Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"Activation of Ca-permeable Kainate Receptor";"Unblocking of NMDA receptors, glutamate binding and activation";"Purine metabolism";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Synaptic adhesion-like molecules";"NrCAM interactions";"Guanosine ribonucleotides de novo biosynthesis";"Trafficking of AMPA receptors";"Long-term potentiation" XP_046737514.1 5 Reactome: R-HSA-3134975;Reactome: R-HSA-3270619;Reactome: R-HSA-6798695;Reactome: R-HSA-3249367;Reactome: R-HSA-1834941 "Regulation of innate immune responses to cytosolic DNA";"IRF3-mediated induction of type I IFN";"Neutrophil degranulation";"STAT6-mediated induction of chemokines";"STING mediated induction of host immune responses" XP_046749277.1 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" XP_046734771.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046743508.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046743427.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046734141.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046741080.1 2 Reactome: R-HSA-2022377;Reactome: R-HSA-6798695 "Metabolism of Angiotensinogen to Angiotensins";"Neutrophil degranulation" XP_046741235.1 4 Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-77387 "Transferrin endocytosis and recycling";"Ion channel transport";"ROS and RNS production in phagocytes";"Insulin receptor recycling" XP_046734730.1 1 Reactome: R-HSA-8866654 "E3 ubiquitin ligases ubiquitinate target proteins" XP_046750699.1 2 Reactome: R-HSA-5619061;Reactome: R-HSA-425397 "Defective SLC33A1 causes spastic paraplegia 42 (SPG42)";"Transport of vitamins, nucleosides, and related molecules" XP_046736186.1 8 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Signaling by Hippo";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human papillomavirus infection" XP_046740131.1 12 Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-167287;Reactome: R-HSA-6804756;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167238 "Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"HIV elongation arrest and recovery";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of Tat-mediated HIV elongation" XP_046738724.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046750239.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046740916.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046746599.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" XP_046752631.1 6 KEGG: 00052+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23 "Galactose metabolism";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation" XP_046743604.1 3 KEGG: 00010+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00052+5.1.3.3 "Glycolysis / Gluconeogenesis";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism" XP_046750775.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046744825.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046737814.1 1 Reactome: R-HSA-442660 "Na+/Cl- dependent neurotransmitter transporters" XP_046741990.1 3 Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" XP_046745341.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046753483.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046746001.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046742559.1 12 Reactome: R-HSA-1169408;Reactome: R-HSA-72662;Reactome: R-HSA-166208;Reactome: R-HSA-450408;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-429947;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-72706 "ISG15 antiviral mechanism";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"mTORC1-mediated signalling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Deadenylation of mRNA";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046736511.1 2 Reactome: R-HSA-5205685;Reactome: R-HSA-983231 "Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production" XP_046739012.1 5 Reactome: R-HSA-5579006;MetaCyc: PWY-8043;KEGG: 00480+6.3.2.3;Reactome: R-HSA-174403;KEGG: 00270+6.3.2.3 "Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Ophthalmate biosynthesis";"Glutathione metabolism";"Glutathione synthesis and recycling";"Cysteine and methionine metabolism" XP_046747775.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046748585.1 5 KEGG: 04070+2.7.7.41;MetaCyc: PWY-5667;MetaCyc: PWY-5981;KEGG: 00564+2.7.7.41;MetaCyc: PWY-7817 "Phosphatidylinositol signaling system";"CDP-diacylglycerol biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046741983.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046748476.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046744124.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046746975.1 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" XP_046750788.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046753905.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046748997.1 4 Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046741662.1 2 Reactome: R-HSA-373752;Reactome: R-HSA-525793 "Netrin-1 signaling";"Myogenesis" XP_046743896.1 4 Reactome: R-HSA-381771;Reactome: R-HSA-400511;Reactome: R-HSA-422085;Reactome: R-HSA-1799339 "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin";"SRP-dependent cotranslational protein targeting to membrane" XP_046751840.1 1 Reactome: R-HSA-9633012 "Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046744186.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046749834.1 2 Reactome: R-HSA-9033241;Reactome: R-HSA-389661 "Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation" XP_046747801.1 8 Reactome: R-HSA-5140745;Reactome: R-HSA-190873;Reactome: R-HSA-8856825;Reactome: R-HSA-432720;Reactome: R-HSA-196025;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828;Reactome: R-HSA-5099900 "WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Gap junction degradation";"Cargo recognition for clathrin-mediated endocytosis";"Lysosome Vesicle Biogenesis";"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD4" XP_046743939.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046744735.1 10 MetaCyc: PWY-6536;MetaCyc: PWY-6535;MetaCyc: PWY-6537;KEGG: 00640+2.6.1.19;KEGG: 00410+2.6.1.19;MetaCyc: PWY-5022;KEGG: 00250+2.6.1.19;Reactome: R-HSA-916853;MetaCyc: PWY-4321;KEGG: 00650+2.6.1.19 "4-aminobutanoate degradation III";"4-aminobutanoate degradation I";"4-aminobutanoate degradation II";"Propanoate metabolism";"beta-Alanine metabolism";"4-aminobutanoate degradation V";"Alanine, aspartate and glutamate metabolism";"Degradation of GABA";"L-glutamate degradation IV";"Butanoate metabolism" XP_046745023.1 3 KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046741338.1 10 Reactome: R-HSA-983231;Reactome: R-HSA-9022692;Reactome: R-HSA-427413;Reactome: R-HSA-400206;Reactome: R-HSA-9615017;Reactome: R-HSA-3899300;Reactome: R-HSA-9022699;Reactome: R-HSA-9022702;Reactome: R-HSA-9022538;Reactome: R-HSA-8936459 "Factors involved in megakaryocyte development and platelet production";"Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression";"Regulation of lipid metabolism by PPARalpha";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"SUMOylation of transcription cofactors";"MECP2 regulates neuronal receptors and channels";"MECP2 regulates transcription of neuronal ligands";"Loss of MECP2 binding ability to 5mC-DNA";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046743746.1 4 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046749577.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046746209.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046749976.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046745935.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046751894.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046753730.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046745058.1 2 Reactome: R-HSA-977225;Reactome: R-HSA-8854214 "Amyloid fiber formation";"TBC/RABGAPs" XP_046752253.1 3 MetaCyc: PWY-7420;KEGG: 00561+3.1.1.23;Reactome: R-HSA-426048 "Monoacylglycerol metabolism (yeast)";"Glycerolipid metabolism";"Arachidonate production from DAG" XP_046746453.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046742942.1 3 Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway" XP_046747701.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection" XP_046738180.1 1 Reactome: R-HSA-68962 "Activation of the pre-replicative complex" XP_046737406.1 13 Reactome: R-HSA-1442490;Reactome: R-HSA-8948216;Reactome: R-HSA-3000178;Reactome: R-HSA-3000157;Reactome: R-HSA-2243919;Reactome: R-HSA-186797;Reactome: R-HSA-3000171;Reactome: R-HSA-216083;Reactome: R-HSA-419037;Reactome: R-HSA-1650814;Reactome: R-HSA-2214320;Reactome: R-HSA-1474244;Reactome: R-HSA-2022090 "Collagen degradation";"Collagen chain trimerization";"ECM proteoglycans";"Laminin interactions";"Crosslinking of collagen fibrils";"Signaling by PDGF";"Non-integrin membrane-ECM interactions";"Integrin cell surface interactions";"NCAM1 interactions";"Collagen biosynthesis and modifying enzymes";"Anchoring fibril formation";"Extracellular matrix organization";"Assembly of collagen fibrils and other multimeric structures" XP_046743325.1 11 Reactome: R-HSA-5685938;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5693554;Reactome: R-HSA-5358606;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5358565 "HDR through Single Strand Annealing (SSA)";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)" XP_046736872.1 1 Reactome: R-HSA-5693607 "Processing of DNA double-strand break ends" XP_046744074.1 17 MetaCyc: PWY-6679;MetaCyc: PWY-5743;Reactome: R-HSA-196780;KEGG: 00061+6.4.1.2;Reactome: R-HSA-163765;Reactome: R-HSA-200425;MetaCyc: PWY-5789;Reactome: R-HSA-3371599;Reactome: R-HSA-2426168;KEGG: 00640+6.4.1.2;MetaCyc: PWY-5744;MetaCyc: PWY-6722;KEGG: 00620+6.4.1.2;KEGG: 00254+6.4.1.2;KEGG: 00720+6.4.1.2;MetaCyc: PWY-4381;MetaCyc: PWY-5966-1 "Jadomycin biosynthesis";"3-hydroxypropanoate cycle";"Biotin transport and metabolism";"Fatty acid biosynthesis";"ChREBP activates metabolic gene expression";"Carnitine metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Defective HLCS causes multiple carboxylase deficiency";"Activation of gene expression by SREBF (SREBP)";"Propanoate metabolism";"Glyoxylate assimilation";"Candicidin biosynthesis";"Pyruvate metabolism";"Aflatoxin biosynthesis";"Carbon fixation pathways in prokaryotes";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)" XP_046748290.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046748043.1 19 Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-3214858;Reactome: R-HSA-8876725;Reactome: R-HSA-6790901;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957 "Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"RMTs methylate histone arginines";"Protein methylation";"rRNA modification in the nucleus and cytosol";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046739215.1 2 Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7 "Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis" XP_046749960.1 6 Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72706 "Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046752093.1 13 MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-7222;MetaCyc: PWY-7227;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7226;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7220;KEGG: 00480+1.17.4.1;KEGG: 00230+1.17.4.1 "Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Purine metabolism" XP_046752645.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046745597.1 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" XP_046750454.1 16 Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957 "Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046745552.1 5 Reactome: R-HSA-2395516;Reactome: R-HSA-1362409;Reactome: R-HSA-5579026;Reactome: R-HSA-211976;Reactome: R-HSA-196108 "Electron transport from NADPH to Ferredoxin";"Mitochondrial iron-sulfur cluster biogenesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Endogenous sterols";"Pregnenolone biosynthesis" XP_046744133.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046747147.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046753382.1 19 Reactome: R-HSA-5673000;Reactome: R-HSA-6802952;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-9649948;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-438066;Reactome: R-HSA-399719;Reactome: R-HSA-442982;Reactome: R-HSA-9022692;Reactome: R-HSA-5673001;Reactome: R-HSA-936837;Reactome: R-HSA-6802955;Reactome: R-HSA-111932;Reactome: R-HSA-9620244;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-6802946 "RAF activation";"Signaling by BRAF and RAF fusions";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Signaling downstream of RAS mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Unblocking of NMDA receptors, glutamate binding and activation";"Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Regulation of MECP2 expression and activity";"RAF/MAP kinase cascade";"Ion transport by P-type ATPases";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"CaMK IV-mediated phosphorylation of CREB";"Long-term potentiation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Signaling by moderate kinase activity BRAF mutants" XP_046738809.1 16 Reactome: R-HSA-176407;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-141430;Reactome: R-HSA-8853884;Reactome: R-HSA-179409;Reactome: R-HSA-174084;Reactome: R-HSA-174048;Reactome: R-HSA-2559582;Reactome: R-HSA-983168;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-176412;Reactome: R-HSA-176408;Reactome: R-HSA-174184;Reactome: R-HSA-176409 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Transcriptional Regulation by VENTX";"APC-Cdc20 mediated degradation of Nek2A";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of Cyclin B";"Senescence-Associated Secretory Phenotype (SASP)";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Phosphorylation of the APC/C";"Regulation of APC/C activators between G1/S and early anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of mitotic proteins" XP_046733756.1 1 Reactome: R-HSA-8963889 "Assembly of active LPL and LIPC lipase complexes" XP_046738400.1 2 Reactome: R-HSA-72764;Reactome: R-HSA-156581 "Eukaryotic Translation Termination";"Methylation" XP_046746649.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046748734.1 2 Reactome: R-HSA-416482;Reactome: R-HSA-456926 "G alpha (12/13) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)" XP_046737657.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046747406.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046735770.1 6 MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817 "Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046740740.1 8 MetaCyc: PWY-7921;Reactome: R-HSA-5173105;MetaCyc: PWY-7922;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5083629 "Protein O-mannosylation I (yeast)";"O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2" XP_046747831.1 6 MetaCyc: PWY-7791;KEGG: 00240+2.4.2.10;Reactome: R-HSA-500753;KEGG: 00983+2.4.2.10;MetaCyc: PWY-5686;MetaCyc: PWY-7790 "UMP biosynthesis III";"Pyrimidine metabolism";"Pyrimidine biosynthesis";"Drug metabolism - other enzymes";"UMP biosynthesis I";"UMP biosynthesis II" XP_046740080.1 2 Reactome: R-HSA-5693568;Reactome: R-HSA-6783310 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway" XP_046747526.1 2 Reactome: R-HSA-189085;Reactome: R-HSA-2129379 "Digestion of dietary carbohydrate";"Molecules associated with elastic fibres" XP_046753752.1 1 KEGG: 00480+3.4.11.1 "Glutathione metabolism" XP_046741618.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046736154.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046739223.1 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" XP_046753232.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046735968.1 1 Reactome: R-HSA-5419276 "Mitochondrial translation termination" XP_046749741.1 9 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5674400;Reactome: R-HSA-198323;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"AKT phosphorylates targets in the cytosol";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046736515.1 2 Reactome: R-HSA-5205685;Reactome: R-HSA-983231 "Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production" XP_046736172.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046736469.1 8 KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5083629;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;Reactome: R-HSA-5173105;MetaCyc: PWY-7922 "Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)" XP_046746579.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046738585.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046752739.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046739064.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046742779.1 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" XP_046735090.1 1 KEGG: 00270+2.1.1.37 "Cysteine and methionine metabolism" XP_046750507.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-1799339 "Neutrophil degranulation";"SRP-dependent cotranslational protein targeting to membrane" XP_046738511.1 5 Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288 "Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1" XP_046739292.1 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" XP_046733879.1 6 KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499;MetaCyc: PWY-6368;Reactome: R-HSA-1660516;KEGG: 00562+3.1.3.66;Reactome: R-HSA-1855183 "Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"3-phosphoinositide degradation";"Synthesis of PIPs at the early endosome membrane";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol" XP_046741107.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046736600.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046751986.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway" XP_046748518.1 3 Reactome: R-HSA-8854214;Reactome: R-HSA-8875656;Reactome: R-HSA-8856828 "TBC/RABGAPs";"MET receptor recycling";"Clathrin-mediated endocytosis" XP_046742405.1 13 KEGG: 00720+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-7384;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5538;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-5392;MetaCyc: PWY-6969;Reactome: R-HSA-71403;MetaCyc: PWY-5537;MetaCyc: PWY-6728 "Carbon fixation pathways in prokaryotes";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"C5-Branched dibasic acid metabolism";"Pyruvate fermentation to acetate VI";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citric acid cycle (TCA cycle)";"Pyruvate fermentation to acetate V";"Methylaspartate cycle" XP_046738979.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046738279.1 8 Reactome: R-HSA-9619483;Reactome: R-HSA-6804756;Reactome: R-HSA-1445148;Reactome: R-HSA-1632852;Reactome: R-HSA-2151209;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-9613354 "Activation of AMPK downstream of NMDARs";"Regulation of TP53 Activity through Phosphorylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Macroautophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Lipophagy" XP_046738017.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046740984.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046753374.1 19 Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-5673001;Reactome: R-HSA-936837;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692;Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-9649948;Reactome: R-HSA-438066;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5576892;Reactome: R-HSA-5673000 "HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"RAF/MAP kinase cascade";"Ion transport by P-type ATPases";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"Signaling downstream of RAS mutants";"Unblocking of NMDA receptors, glutamate binding and activation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"Phase 0 - rapid depolarisation";"RAF activation" XP_046739024.1 14 MetaCyc: PWY-5667;MetaCyc: PWY-7587;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7589;MetaCyc: PWY-8051;MetaCyc: PWY-6453;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7411;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7417;MetaCyc: PWY-5981 "CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism";"Palmitoleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"Plasmalogen biosynthesis";"Synthesis of PA";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III" XP_046739294.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046743745.1 4 Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway" XP_046751542.1 1 MetaCyc: PWY-7437 "Protein O-[N-acetyl]-glucosylation" XP_046744139.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046742164.1 13 Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-6791226 "Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046739860.1 2 Reactome: R-HSA-5578999;Reactome: R-HSA-174403 "Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Glutathione synthesis and recycling" XP_046748596.1 5 KEGG: 00564+2.7.7.41;MetaCyc: PWY-7817;MetaCyc: PWY-5981;MetaCyc: PWY-5667;KEGG: 04070+2.7.7.41 "Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"CDP-diacylglycerol biosynthesis III";"CDP-diacylglycerol biosynthesis I";"Phosphatidylinositol signaling system" XP_046748490.1 3 Reactome: R-HSA-6798695;Reactome: R-HSA-6807878;Reactome: R-HSA-6811434 "Neutrophil degranulation";"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046740343.1 1 Reactome: R-HSA-419037 "NCAM1 interactions" XP_046738732.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046746084.1 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" XP_046739712.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095 "Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins" XP_046752472.1 12 Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-381038;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-2132295;Reactome: R-HSA-8854518 "Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"XBP1(S) activates chaperone genes";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"MHC class II antigen presentation";"AURKA Activation by TPX2" XP_046748040.1 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" XP_046745278.1 5 Reactome: R-HSA-166166;Reactome: R-HSA-168164;Reactome: R-HSA-937072;Reactome: R-HSA-936964;Reactome: R-HSA-937041 "MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1" XP_046736109.1 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" XP_046738528.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" XP_046739994.1 2 KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10 "One carbon pool by folate";"Glycine, serine and threonine metabolism" XP_046734328.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046750703.1 4 Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-3000178 "MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions";"ECM proteoglycans" XP_046743694.1 1 Reactome: R-HSA-203641 "NOSTRIN mediated eNOS trafficking" XP_046751428.1 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.4 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046740900.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046742617.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046743998.1 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" XP_046739995.1 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" XP_046750715.1 7 Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-166208 "Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"Macroautophagy";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling" XP_046743326.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046734664.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046742907.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046751659.1 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" XP_046738364.1 1 Reactome: R-HSA-433137 "Sodium-coupled sulphate, di- and tri-carboxylate transporters" XP_046738026.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046734433.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440 "COPI-mediated anterograde transport";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network" XP_046738806.1 4 KEGG: 00564+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32 "Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism" XP_046752984.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046748110.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046743522.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046743945.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046741958.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046739257.1 2 Reactome: R-HSA-379726;KEGG: 00970+6.1.1.15 "Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046740543.1 1 KEGG: 00970+6.1.1.7 "Aminoacyl-tRNA biosynthesis" XP_046748112.1 5 MetaCyc: PWY-6906;MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6;MetaCyc: PWY-5514;Reactome: R-HSA-70171 "Chitin derivatives degradation";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Glycolysis" XP_046736004.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046749488.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-8964038 "Neutrophil degranulation";"LDL clearance" XP_046752457.1 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" XP_046747920.1 26 Reactome: R-HSA-210744;Reactome: R-HSA-933541;Reactome: R-HSA-9617629;Reactome: R-HSA-3134973;Reactome: R-HSA-8866907;Reactome: R-HSA-8941856;Reactome: R-HSA-2894862;Reactome: R-HSA-3371568;Reactome: R-HSA-2644606;Reactome: R-HSA-201722;Reactome: R-HSA-1912408;Reactome: R-HSA-9013508;Reactome: R-HSA-9013695;Reactome: R-HSA-5617472;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-2122947;Reactome: R-HSA-9614657;Reactome: R-HSA-5621575;Reactome: R-HSA-918233;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-3214847;Reactome: R-HSA-1368082;Reactome: R-HSA-3899300;Reactome: R-HSA-1234158 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"TRAF6 mediated IRF7 activation";"Regulation of FOXO transcriptional activity by acetylation";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Activation of the TFAP2 (AP-2) family of transcription factors";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Attenuation phase";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Formation of the beta-catenin:TCF transactivating complex";"Pre-NOTCH Transcription and Translation";"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Estrogen-dependent gene expression";"PPARA activates gene expression";"NOTCH1 Intracellular Domain Regulates Transcription";"FOXO-mediated transcription of cell death genes";"CD209 (DC-SIGN) signaling";"TRAF3-dependent IRF activation pathway";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"HATs acetylate histones";"RORA activates gene expression";"SUMOylation of transcription cofactors";"Regulation of gene expression by Hypoxia-inducible Factor" XP_046743812.1 3 MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2 "Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism" XP_046746436.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046740284.1 3 Reactome: R-HSA-975574;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.144 "Reactions specific to the hybrid N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis" XP_046737292.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046741171.1 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" XP_046735628.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046743512.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046753302.1 1 Reactome: R-HSA-2428928 "IRS-related events triggered by IGF1R" XP_046744588.1 18 Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-3108214;Reactome: R-HSA-912446;Reactome: R-HSA-8953750;Reactome: R-HSA-69473;Reactome: R-HSA-1221632;Reactome: R-HSA-5693554;Reactome: R-HSA-6796648;Reactome: R-HSA-5685938;Reactome: R-HSA-5689901;Reactome: R-HSA-5693571;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;MetaCyc: PWY-7511;Reactome: R-HSA-5693565;Reactome: R-HSA-5685942 "Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"SUMOylation of DNA damage response and repair proteins";"Meiotic recombination";"Transcriptional Regulation by E2F6";"G2/M DNA damage checkpoint";"Meiotic synapsis";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"TP53 Regulates Transcription of DNA Repair Genes";"HDR through Single Strand Annealing (SSA)";"Metalloprotease DUBs";"Nonhomologous End-Joining (NHEJ)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Protein ubiquitination";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDR through Homologous Recombination (HRR)" XP_046733750.1 2 Reactome: R-HSA-8949215;Reactome: R-HSA-5689880 "Mitochondrial calcium ion transport";"Ub-specific processing proteases" XP_046748260.1 3 KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154 "Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase" XP_046742746.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046736221.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046753426.1 5 MetaCyc: PWY-7269;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23 "NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism" XP_046748142.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097 "RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway" XP_046743658.1 10 Reactome: R-HSA-1445148;Reactome: R-HSA-163680;Reactome: R-HSA-6804756;Reactome: R-HSA-200425;Reactome: R-HSA-9619483;Reactome: R-HSA-9613354;Reactome: R-HSA-2151209;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation";"Carnitine metabolism";"Activation of AMPK downstream of NMDARs";"Lipophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy" XP_046752052.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046737658.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046735299.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046741959.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046736876.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046739374.1 14 MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7417;MetaCyc: PWY-5981;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-5667;MetaCyc: PWY-7587;MetaCyc: PWY-7589;KEGG: 00564+2.3.1.51 "Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Plasmalogen biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Palmitoleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism" XP_046743489.1 3 KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348 "Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition" XP_046744738.1 6 Reactome: R-HSA-913709;MetaCyc: PWY-7433;KEGG: 00514+2.4.1.122;Reactome: R-HSA-5083632;MetaCyc: PWY-7290;KEGG: 00512+2.4.1.122 "O-linked glycosylation of mucins";"Mucin core 1 and core 2 O-glycosylation";"Other types of O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Escherichia coli serotype O86 O-antigen biosynthesis";"Mucin type O-glycan biosynthesis" XP_046737642.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046738304.1 2 Reactome: R-HSA-163282;Reactome: R-HSA-2151201 "Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis" XP_046738340.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046738909.1 17 Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6790901;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702 "Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"rRNA modification in the nucleus and cytosol";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition" XP_046746757.1 9 Reactome: R-HSA-113501;Reactome: R-HSA-174430;Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-69205;Reactome: R-HSA-68952;Reactome: R-HSA-69183;Reactome: R-HSA-69166;Reactome: R-HSA-69091 "Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Telomere C-strand synthesis initiation";"Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"G1/S-Specific Transcription";"DNA replication initiation";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate";"Polymerase switching" XP_046747875.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046748344.1 3 Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340 "PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation" XP_046742316.1 6 Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease" XP_046745339.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046748173.1 1 Reactome: R-HSA-203927 "MicroRNA (miRNA) biogenesis" XP_046736748.1 1 Reactome: R-HSA-9033241 "Peroxisomal protein import" XP_046742989.1 1 Reactome: R-HSA-1655829 "Regulation of cholesterol biosynthesis by SREBP (SREBF)" XP_046735973.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046745655.1 2 Reactome: R-HSA-975957;Reactome: R-HSA-9010553 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" XP_046744131.1 2 Reactome: R-HSA-6783310;Reactome: R-HSA-6796648 "Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes" XP_046741167.1 4 MetaCyc: PWY-7511;Reactome: R-HSA-937039;Reactome: R-HSA-975144;Reactome: R-HSA-9020702 "Protein ubiquitination";"IRAK1 recruits IKK complex";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Interleukin-1 signaling" XP_046745302.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046747053.1 1 Reactome: R-HSA-5610787 "Hedgehog 'off' state" XP_046737732.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046752875.1 1 Reactome: R-HSA-1362409 "Mitochondrial iron-sulfur cluster biogenesis" XP_046736063.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046738111.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway" XP_046739622.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046734003.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046740342.1 1 Reactome: R-HSA-419037 "NCAM1 interactions" XP_046735266.1 18 KEGG: 00330+2.6.1.1;MetaCyc: PWY-6642;MetaCyc: PWY-7117;MetaCyc: PWY-7383;MetaCyc: PWY-5913;MetaCyc: PWY-7115;KEGG: 00350+2.6.1.1;KEGG: 00950+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00960+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00270+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00400+2.6.1.1;MetaCyc: PWY-6638 "Arginine and proline metabolism";"(R)-cysteate degradation";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Partial TCA cycle (obligate autotrophs)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Tyrosine metabolism";"Isoquinoline alkaloid biosynthesis";"Coenzyme M biosynthesis II";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Carbon fixation in photosynthetic organisms";"Phenylalanine metabolism";"Novobiocin biosynthesis";"Alanine, aspartate and glutamate metabolism";"Cysteine and methionine metabolism";"Arginine biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Sulfolactate degradation III" XP_046747778.1 2 Reactome: R-HSA-4641265;Reactome: R-HSA-5339700 "Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP" XP_046750989.1 1 Reactome: R-HSA-4085001 "Sialic acid metabolism" XP_046744906.1 12 Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-6804756;Reactome: R-HSA-167287;Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-167290;Reactome: R-HSA-112382 "Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Regulation of TP53 Activity through Phosphorylation";"HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex" XP_046748278.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046744263.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046752986.1 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" XP_046735931.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046749980.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046737358.1 4 Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825 "DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis" XP_046743853.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046743131.1 2 MetaCyc: PWY-6854;Reactome: R-HSA-3299685 "Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species" XP_046752729.1 56 Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-1236974;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-4641258;Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-450408;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764 "Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"ER-Phagosome pathway";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Degradation of DVL";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Degradation of AXIN";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling" XP_046738121.1 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" XP_046735546.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046736399.1 2 Reactome: R-HSA-1799339;Reactome: R-HSA-381038 "SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes" XP_046751997.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046739625.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046746984.1 13 MetaCyc: PWY-6545;KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7220;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7226;Reactome: R-HSA-499943;MetaCyc: PWY-7184;MetaCyc: PWY-7210;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7222 "Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Glutathione metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II" XP_046745358.1 2 Reactome: R-HSA-1296072;Reactome: R-HSA-5576894 "Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels" XP_046753790.1 3 Reactome: R-HSA-5696395;Reactome: R-HSA-5689877;Reactome: R-HSA-5696394 "Formation of Incision Complex in GG-NER";"Josephin domain DUBs";"DNA Damage Recognition in GG-NER" XP_046747710.1 3 Reactome: R-HSA-202427;Reactome: R-HSA-6807004;Reactome: R-HSA-6798695 "Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity";"Neutrophil degranulation" XP_046740659.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046751978.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" XP_046751392.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046736316.1 4 Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-5576893 "Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Phase 2 - plateau phase" XP_046741465.1 13 Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-975957 "Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046749457.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription" XP_046743109.1 12 Reactome: R-HSA-9017802;Reactome: R-HSA-2122948;Reactome: R-HSA-205043;Reactome: R-HSA-2894862;Reactome: R-HSA-3928665;Reactome: R-HSA-2979096;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-9013700;Reactome: R-HSA-1251985;Reactome: R-HSA-977225;Reactome: R-HSA-193692 "Noncanonical activation of NOTCH3";"Activated NOTCH1 Transmits Signal to the Nucleus";"NRIF signals cell death from the nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"EPH-ephrin mediated repulsion of cells";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"Amyloid fiber formation";"Regulated proteolysis of p75NTR" XP_046744891.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046741364.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046751712.1 8 Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-3214841;Reactome: R-HSA-8953750;Reactome: R-HSA-8943724;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472 "HCMV Early Events";"SUMOylation of chromatin organization proteins";"PKMTs methylate histone lysines";"Transcriptional Regulation by E2F6";"Regulation of PTEN gene transcription";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis" XP_046737180.1 4 Reactome: R-HSA-72731;MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174 "Recycling of eIF2:GDP";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II" XP_046738748.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046745462.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046741037.1 19 Reactome: R-HSA-8964026;Reactome: R-HSA-8964041;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471;Reactome: R-HSA-8957275;Reactome: R-HSA-975634;Reactome: R-HSA-8964038;Reactome: R-HSA-202733;Reactome: R-HSA-8963888;Reactome: R-HSA-8964046;Reactome: R-HSA-3000480;Reactome: R-HSA-8963901;Reactome: R-HSA-3000484;Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-8856825;Reactome: R-HSA-3000497;Reactome: R-HSA-8856828;Reactome: R-HSA-381426 "Chylomicron clearance";"LDL remodeling";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors";"Post-translational protein phosphorylation";"Retinoid metabolism and transport";"LDL clearance";"Cell surface interactions at the vascular wall";"Chylomicron assembly";"VLDL clearance";"Scavenging by Class A Receptors";"Chylomicron remodeling";"Scavenging by Class F Receptors";"Platelet sensitization by LDL";"VLDL assembly";"Cargo recognition for clathrin-mediated endocytosis";"Scavenging by Class H Receptors";"Clathrin-mediated endocytosis";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" XP_046745973.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046751887.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046753047.1 2 KEGG: 00970+6.1.1.1;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" XP_046738880.1 16 Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695 "Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex" XP_046738989.1 3 Reactome: R-HSA-611105;Reactome: R-HSA-6799198;Reactome: R-HSA-1268020 "Respiratory electron transport";"Complex I biogenesis";"Mitochondrial protein import" XP_046753770.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046750785.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046735923.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046750077.1 57 Reactome: R-HSA-1236974;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-450408;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-6798695;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880 "ER-Phagosome pathway";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of AXIN";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"Neutrophil degranulation";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases" XP_046744218.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046752613.1 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" XP_046752952.1 2 Reactome: R-HSA-8963888;Reactome: R-HSA-8866423 "Chylomicron assembly";"VLDL assembly" XP_046752813.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046738148.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046741379.1 4 Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" XP_046743596.1 2 Reactome: R-HSA-9603798;Reactome: R-HSA-1369062 "Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis" XP_046742675.1 3 Reactome: R-HSA-1474151;KEGG: 00790+1.1.1.153;Reactome: R-HSA-203615 "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis";"eNOS activation" XP_046744820.1 5 Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-6804758 "RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"Regulation of TP53 Activity through Acetylation" XP_046748761.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046734675.1 3 Reactome: R-HSA-9603798;Reactome: R-HSA-8866654;Reactome: R-HSA-9033241 "Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import" XP_046737926.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046739359.1 6 Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-6798695;Reactome: R-HSA-6781823;Reactome: R-HSA-72163;Reactome: R-HSA-6781827 "Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Neutrophil degranulation";"Formation of TC-NER Pre-Incision Complex";"mRNA Splicing - Major Pathway";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)" XP_046747045.1 1 Reactome: R-HSA-400253 "Circadian Clock" XP_046740269.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046744979.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046738137.1 8 Reactome: R-HSA-432040;Reactome: R-HSA-180024;Reactome: R-HSA-163615;Reactome: R-HSA-442720;Reactome: R-HSA-5610787;Reactome: R-HSA-381676;Reactome: R-HSA-983231;Reactome: R-HSA-164378 "Vasopressin regulates renal water homeostasis via Aquaporins";"DARPP-32 events";"PKA activation";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Hedgehog 'off' state";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Factors involved in megakaryocyte development and platelet production";"PKA activation in glucagon signalling" XP_046753321.1 19 Reactome: R-HSA-9022692;Reactome: R-HSA-5673001;Reactome: R-HSA-936837;Reactome: R-HSA-6802955;Reactome: R-HSA-111932;Reactome: R-HSA-9620244;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-6802946;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-6802952;Reactome: R-HSA-5673000;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-9649948;Reactome: R-HSA-438066;Reactome: R-HSA-399719;Reactome: R-HSA-442982 "Regulation of MECP2 expression and activity";"RAF/MAP kinase cascade";"Ion transport by P-type ATPases";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"CaMK IV-mediated phosphorylation of CREB";"Long-term potentiation";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by moderate kinase activity BRAF mutants";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Signaling by BRAF and RAF fusions";"RAF activation";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Signaling downstream of RAS mutants";"Unblocking of NMDA receptors, glutamate binding and activation";"Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor" XP_046749462.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046749109.1 5 Reactome: R-HSA-5545619;Reactome: R-HSA-4641257;Reactome: R-HSA-5689880;Reactome: R-HSA-201681;Reactome: R-HSA-8948751 "XAV939 inhibits tankyrase, stabilizing AXIN";"Degradation of AXIN";"Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"Regulation of PTEN stability and activity" XP_046752896.1 2 Reactome: R-HSA-917729;Reactome: R-HSA-162588 "Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion" XP_046743751.1 4 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046743402.1 5 KEGG: 04660+3.1.3.16;Reactome: R-HSA-5675221;Reactome: R-HSA-112409;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"Negative regulation of MAPK pathway";"RAF-independent MAPK1/3 activation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046744078.1 17 KEGG: 00061+6.4.1.2;Reactome: R-HSA-163765;MetaCyc: PWY-6679;Reactome: R-HSA-196780;MetaCyc: PWY-5743;MetaCyc: PWY-5744;Reactome: R-HSA-200425;Reactome: R-HSA-3371599;MetaCyc: PWY-5789;Reactome: R-HSA-2426168;KEGG: 00640+6.4.1.2;KEGG: 00620+6.4.1.2;MetaCyc: PWY-6722;MetaCyc: PWY-4381;MetaCyc: PWY-5966-1;KEGG: 00254+6.4.1.2;KEGG: 00720+6.4.1.2 "Fatty acid biosynthesis";"ChREBP activates metabolic gene expression";"Jadomycin biosynthesis";"Biotin transport and metabolism";"3-hydroxypropanoate cycle";"Glyoxylate assimilation";"Carnitine metabolism";"Defective HLCS causes multiple carboxylase deficiency";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Activation of gene expression by SREBF (SREBP)";"Propanoate metabolism";"Pyruvate metabolism";"Candicidin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Aflatoxin biosynthesis";"Carbon fixation pathways in prokaryotes" XP_046735479.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway" XP_046742291.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046737774.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046734326.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046747913.1 26 Reactome: R-HSA-918233;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-3899300;Reactome: R-HSA-3214847;Reactome: R-HSA-1368082;Reactome: R-HSA-1234158;Reactome: R-HSA-9013508;Reactome: R-HSA-5617472;Reactome: R-HSA-9013695;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-2122947;Reactome: R-HSA-9614657;Reactome: R-HSA-5621575;Reactome: R-HSA-2894862;Reactome: R-HSA-3371568;Reactome: R-HSA-2644606;Reactome: R-HSA-201722;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-933541;Reactome: R-HSA-9617629;Reactome: R-HSA-8941856;Reactome: R-HSA-8866907;Reactome: R-HSA-3134973 "TRAF3-dependent IRF activation pathway";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"SUMOylation of transcription cofactors";"HATs acetylate histones";"RORA activates gene expression";"Regulation of gene expression by Hypoxia-inducible Factor";"NOTCH3 Intracellular Domain Regulates Transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"NOTCH4 Intracellular Domain Regulates Transcription";"PPARA activates gene expression";"Estrogen-dependent gene expression";"NOTCH1 Intracellular Domain Regulates Transcription";"FOXO-mediated transcription of cell death genes";"CD209 (DC-SIGN) signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Attenuation phase";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Formation of the beta-catenin:TCF transactivating complex";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"TRAF6 mediated IRF7 activation";"Regulation of FOXO transcriptional activity by acetylation";"RUNX3 regulates NOTCH signaling";"Activation of the TFAP2 (AP-2) family of transcription factors";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" XP_046747276.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046743702.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046748699.1 6 Reactome: R-HSA-196807;MetaCyc: PWY-5653;KEGG: 00760+6.3.1.5;KEGG: 00760+6.3.5.1;MetaCyc: PWY-5381;MetaCyc: PWY-7761 "Nicotinate metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)" XP_046736203.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046742916.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" XP_046750490.1 3 KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508;Reactome: R-HSA-418597 "Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"G alpha (z) signalling events" XP_046751612.1 8 MetaCyc: PWY-7391;MetaCyc: PWY-922;Reactome: R-HSA-191273;Reactome: R-HSA-1989781;MetaCyc: PWY-6174;MetaCyc: PWY-7524;KEGG: 00900+1.1.1.34;Reactome: R-HSA-2426168 "Isoprene biosynthesis II (engineered)";"Mevalonate pathway I";"Cholesterol biosynthesis";"PPARA activates gene expression";"Mevalonate pathway II (archaea)";"Mevalonate pathway III (archaea)";"Terpenoid backbone biosynthesis";"Activation of gene expression by SREBF (SREBP)" XP_046745704.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046741582.1 5 MetaCyc: PWY-5381;MetaCyc: PWY-7761;Reactome: R-HSA-196807;MetaCyc: PWY-5653;KEGG: 00760+2.7.7.18 "Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism" XP_046748272.1 2 Reactome: R-HSA-5339700;Reactome: R-HSA-4641265 "TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes" XP_046743310.1 4 Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)" XP_046745962.1 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046753015.1 13 MetaCyc: PWY-7883;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;Reactome: R-HSA-2160916;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00511+3.2.1.52;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101 "Anhydromuropeptides recycling II";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"Hyaluronan uptake and degradation";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"CS/DS degradation" XP_046746042.1 2 Reactome: R-HSA-6782315;MetaCyc: PWY-6829 "tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)" XP_046749297.1 5 Reactome: R-HSA-6807004;Reactome: R-HSA-182971;Reactome: R-HSA-8856828;Reactome: R-HSA-8875360;Reactome: R-HSA-8856825 "Negative regulation of MET activity";"EGFR downregulation";"Clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis" XP_046744507.1 2 Reactome: R-HSA-983168;Reactome: R-HSA-110320 "Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH" XP_046753239.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046734448.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046734009.1 6 Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-450385;Reactome: R-HSA-380994 "KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress" XP_046753620.1 13 Reactome: R-HSA-445989;Reactome: R-HSA-9020702;Reactome: R-HSA-5607764;Reactome: R-HSA-9014325;Reactome: R-HSA-450321;Reactome: R-HSA-975163;Reactome: R-HSA-2871837;Reactome: R-HSA-450302;Reactome: R-HSA-168638;Reactome: R-HSA-9645460;Reactome: R-HSA-937042;Reactome: R-HSA-937072;Reactome: R-HSA-5357956 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Interleukin-1 signaling";"CLEC7A (Dectin-1) signaling";"TICAM1,TRAF6-dependent induction of TAK1 complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"FCERI mediated NF-kB activation";"activated TAK1 mediates p38 MAPK activation";"NOD1/2 Signaling Pathway";"Alpha-protein kinase 1 signaling pathway";"IRAK2 mediated activation of TAK1 complex";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway" XP_046744485.1 7 Reactome: R-HSA-606279;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813 "Deposition of new CENPA-containing nucleosomes at the centromere";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids" XP_046741767.1 27 Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-159227;Reactome: R-HSA-4570464;Reactome: R-HSA-180910 "Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"HCMV Late Events";"SUMOylation of DNA replication proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs" XP_046747212.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046750867.1 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" XP_046740273.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046735887.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046749394.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046737441.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046744079.1 17 Reactome: R-HSA-163765;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6679;MetaCyc: PWY-5743;Reactome: R-HSA-196780;MetaCyc: PWY-5744;MetaCyc: PWY-5789;Reactome: R-HSA-3371599;Reactome: R-HSA-200425;KEGG: 00640+6.4.1.2;Reactome: R-HSA-2426168;KEGG: 00620+6.4.1.2;MetaCyc: PWY-6722;MetaCyc: PWY-4381;MetaCyc: PWY-5966-1;KEGG: 00720+6.4.1.2;KEGG: 00254+6.4.1.2 "ChREBP activates metabolic gene expression";"Fatty acid biosynthesis";"Jadomycin biosynthesis";"3-hydroxypropanoate cycle";"Biotin transport and metabolism";"Glyoxylate assimilation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Defective HLCS causes multiple carboxylase deficiency";"Carnitine metabolism";"Propanoate metabolism";"Activation of gene expression by SREBF (SREBP)";"Pyruvate metabolism";"Candicidin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Carbon fixation pathways in prokaryotes";"Aflatoxin biosynthesis" XP_046736855.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046750334.1 6 Reactome: R-HSA-4411364;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-4086398;Reactome: R-HSA-8951430;Reactome: R-HSA-3769402 "Binding of TCF/LEF:CTNNB1 to target gene promoters";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Ca2+ pathway";"RUNX3 regulates WNT signaling";"Deactivation of the beta-catenin transactivating complex" XP_046745333.1 5 Reactome: R-HSA-189451;KEGG: 00260+2.3.1.37;KEGG: 00860+2.3.1.37;MetaCyc: PWY-7536;MetaCyc: PWY-5189 "Heme biosynthesis";"Glycine, serine and threonine metabolism";"Porphyrin and chlorophyll metabolism";"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)" XP_046739375.1 14 MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7589;MetaCyc: PWY-5667;MetaCyc: PWY-7587;MetaCyc: PWY-7417;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7411 "Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Plasmalogen biosynthesis";"Synthesis of PA";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)" XP_046747145.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046741008.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046741478.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046753294.1 4 Reactome: R-HSA-2468052;Reactome: R-HSA-2467813;Reactome: R-HSA-2470946;Reactome: R-HSA-2500257 "Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion" XP_046736982.1 7 MetaCyc: PWY-6124;KEGG: 00230+4.3.2.2;MetaCyc: PWY-7219;MetaCyc: PWY-6123;KEGG: 00250+4.3.2.2;MetaCyc: PWY-7234;Reactome: R-HSA-73817 "Inosine-5'-phosphate biosynthesis II";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Inosine-5'-phosphate biosynthesis I";"Alanine, aspartate and glutamate metabolism";"Inosine-5'-phosphate biosynthesis III";"Purine ribonucleoside monophosphate biosynthesis" XP_046750588.1 6 Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942 "Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)" XP_046753856.1 3 Reactome: R-HSA-983168;Reactome: R-HSA-3065678;Reactome: R-HSA-3065676 "Antigen processing: Ubiquitination & Proteasome degradation";"SUMO is transferred from E1 to E2 (UBE2I, UBC9)";"SUMO is conjugated to E1 (UBA2:SAE1)" XP_046744416.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046738836.1 14 KEGG: 00592+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7417;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;MetaCyc: PWY-8051;Reactome: R-HSA-975634;KEGG: 00591+3.1.1.4 "alpha-Linolenic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Plasmalogen degradation";"Arachidonic acid metabolism";"Glycerophospholipid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Anandamide biosynthesis I";"Retinoid metabolism and transport";"Linoleic acid metabolism" XP_046738700.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046746604.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046749700.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046745813.1 8 Reactome: R-HSA-437239;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Recycling pathway of L1";"Relaxin signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046751394.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046740856.1 10 MetaCyc: PWY-6352;KEGG: 04070+2.7.1.153;Reactome: R-HSA-9027276;KEGG: 04150+2.7.1.153;KEGG: 05165+2.7.1.153;KEGG: 00562+2.7.1.153;KEGG: 05163+2.7.1.153;KEGG: 05170+2.7.1.153;KEGG: 04151+2.7.1.153;Reactome: R-HSA-1660499 "3-phosphoinositide biosynthesis";"Phosphatidylinositol signaling system";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"mTOR signaling pathway";"Human papillomavirus infection";"Inositol phosphate metabolism";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Synthesis of PIPs at the plasma membrane" XP_046736249.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046749754.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046753013.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046736153.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046741238.1 5 Reactome: R-HSA-5693571;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-5689901;Reactome: R-HSA-5693565 "Nonhomologous End-Joining (NHEJ)";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Metalloprotease DUBs";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" XP_046752304.1 12 MetaCyc: PWY-5133;KEGG: 00640+6.2.1.1;KEGG: 00720+6.2.1.1;MetaCyc: PWY-7857;MetaCyc: PWY-7118;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5132;KEGG: 00620+6.2.1.1;MetaCyc: PWY-5108;MetaCyc: PWY-6672;KEGG: 00630+6.2.1.1;KEGG: 00010+6.2.1.1 "Colupulone and cohumulone biosynthesis";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Adlupulone and adhumulone biosynthesis";"Chitin degradation to ethanol";"Methane metabolism";"Lupulone and humulone biosynthesis";"Pyruvate metabolism";"L-isoleucine biosynthesis V";"Cis-genanyl-coa degradation";"Glyoxylate and dicarboxylate metabolism";"Glycolysis / Gluconeogenesis" XP_046747537.1 3 Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" XP_046753045.1 4 KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193 "Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I" XP_046752817.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046740132.1 12 Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-6804756;Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-167290;Reactome: R-HSA-112382 "Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Regulation of TP53 Activity through Phosphorylation";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex" XP_046750040.1 2 Reactome: R-HSA-69273;Reactome: R-HSA-8862803 "Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" XP_046743652.1 56 Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-5676590 "Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"UCH proteinases";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Degradation of DVL";"Downstream TCR signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"NIK-->noncanonical NF-kB signaling" XP_046747848.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046734307.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046747286.1 8 Reactome: R-HSA-5683826;KEGG: 00230+3.5.4.4;MetaCyc: PWY-6609;MetaCyc: PWY-7179;MetaCyc: PWY-6611;Reactome: R-HSA-74217;Reactome: R-HSA-6798695;MetaCyc: PWY-7179-1 "Surfactant metabolism";"Purine metabolism";"Adenine and adenosine salvage III";"Purine deoxyribonucleosides degradation I";"Adenine and adenosine salvage V";"Purine salvage";"Neutrophil degranulation";"Purine deoxyribonucleosides degradation II" XP_046753948.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046736318.1 4 Reactome: R-HSA-5576893;Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-419037 "Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"NCAM1 interactions" XP_046738526.1 7 Reactome: R-HSA-9033241;KEGG: 00280+4.1.3.4;MetaCyc: PWY-5074;Reactome: R-HSA-77111;KEGG: 00281+4.1.3.4;KEGG: 00072+4.1.3.4;KEGG: 00650+4.1.3.4 "Peroxisomal protein import";"Valine, leucine and isoleucine degradation";"Mevalonate degradation";"Synthesis of Ketone Bodies";"Geraniol degradation";"Synthesis and degradation of ketone bodies";"Butanoate metabolism" XP_046749347.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046740559.1 2 KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336 "Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway" XP_046750383.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046734869.1 7 KEGG: 00790+1.14.16.1;MetaCyc: PWY-6134;KEGG: 00400+1.14.16.1;Reactome: R-HSA-8964208;KEGG: 00360+1.14.16.1;Reactome: R-HSA-2160456;MetaCyc: PWY-7158 "Folate biosynthesis";"L-tyrosine biosynthesis IV";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Phenylalanine metabolism";"Phenylalanine metabolism";"Phenylketonuria";"L-phenylalanine degradation V" XP_046748625.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046739668.1 4 Reactome: R-HSA-5579026;Reactome: R-HSA-196108;Reactome: R-HSA-211976;Reactome: R-HSA-2395516 "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Pregnenolone biosynthesis";"Endogenous sterols";"Electron transport from NADPH to Ferredoxin" XP_046736736.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046743515.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046741957.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046739713.1 31 Reactome: R-HSA-163765;MetaCyc: PWY-7723;MetaCyc: PWY-5994;MetaCyc: PWY-5366;MetaCyc: PWY-7746;Reactome: R-HSA-199220;MetaCyc: PWY-8012;Reactome: R-HSA-9029558;MetaCyc: PWY-8049;MetaCyc: PWY-7858;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-2426168;MetaCyc: PWY-5147;MetaCyc: PWY-6113;MetaCyc: PWY-7663;Reactome: R-HSA-75105;MetaCyc: PWY-5971;MetaCyc: PWY-7664;MetaCyc: PWY-6799;MetaCyc: PWY-5973;MetaCyc: PWY-4381;MetaCyc: PWY-7388;MetaCyc: PWY-5367;MetaCyc: PWY-5966-1;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWYG-321;MetaCyc: PWY-5989;MetaCyc: PWY-6282;MetaCyc: PWY-8047;MetaCyc: PWY-5142;MetaCyc: PWY-6519 "ChREBP activates metabolic gene expression";"Bacterial bioluminescence";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis II (plants and bacteria)";"Mycobacterial sulfolipid biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Mupirocin biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Pederin biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Biotin metabolism";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis I (plants)";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"Fatty acyl-CoA biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis IV (anaerobic)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis";"";"Stearate biosynthesis II (bacteria and plants)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Bryostatin biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"8-amino-7-oxononanoate biosynthesis I" XP_046738670.1 7 Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-73980 "RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination" XP_046737482.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046743461.1 1 Reactome: R-HSA-880009 "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" XP_046742461.1 3 MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646 "Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification" XP_046744190.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046751614.1 6 MetaCyc: PWY-6368;Reactome: R-HSA-194840;Reactome: R-HSA-1855204;KEGG: 04070+3.1.3.36;KEGG: 00562+3.1.3.36;Reactome: R-HSA-1855183 "3-phosphoinositide degradation";"Rho GTPase cycle";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol" XP_046750063.1 5 Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-201722;Reactome: R-HSA-8866654 "Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of the beta-catenin:TCF transactivating complex";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046739425.1 8 Reactome: R-HSA-9617324;Reactome: R-HSA-442982;MetaCyc: PWY-7221;Reactome: R-HSA-9620244;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-438066;KEGG: 00230+2.7.4.8 "Negative regulation of NMDA receptor-mediated neuronal transmission";"Ras activation upon Ca2+ influx through NMDA receptor";"Guanosine ribonucleotides de novo biosynthesis";"Long-term potentiation";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"Unblocking of NMDA receptors, glutamate binding and activation";"Purine metabolism" XP_046739534.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046752302.1 12 KEGG: 00620+6.2.1.1;MetaCyc: PWY-5108;MetaCyc: PWY-6672;KEGG: 00630+6.2.1.1;KEGG: 00010+6.2.1.1;MetaCyc: PWY-5132;MetaCyc: PWY-7118;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5133;KEGG: 00640+6.2.1.1;KEGG: 00720+6.2.1.1;MetaCyc: PWY-7857 "Pyruvate metabolism";"L-isoleucine biosynthesis V";"Cis-genanyl-coa degradation";"Glyoxylate and dicarboxylate metabolism";"Glycolysis / Gluconeogenesis";"Lupulone and humulone biosynthesis";"Chitin degradation to ethanol";"Methane metabolism";"Colupulone and cohumulone biosynthesis";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Adlupulone and adhumulone biosynthesis" XP_046738376.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046750754.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046747735.1 13 Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72706 "Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046753671.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046734464.1 5 MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6317;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6527 "D-galactose detoxification";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation" XP_046744477.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046752798.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046748309.1 7 Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-1538133;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69202;Reactome: R-HSA-156711 "Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G0 and Early G1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin E associated events during G1/S transition";"Polo-like kinase mediated events" XP_046735804.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046751205.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046741716.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046739842.1 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" XP_046746455.1 7 Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-3108214;Reactome: R-HSA-2500257;Reactome: R-HSA-1221632;Reactome: R-HSA-9018519;Reactome: R-HSA-2470946 "Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"SUMOylation of DNA damage response and repair proteins";"Resolution of Sister Chromatid Cohesion";"Meiotic synapsis";"Estrogen-dependent gene expression";"Cohesin Loading onto Chromatin" XP_046746044.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046745892.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046749367.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046748258.1 3 Reactome: R-HSA-445355;Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2 "Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase";"Purine metabolism" XP_046744840.1 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046736338.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046739594.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046741731.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046745949.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046734104.1 1 KEGG: 00970+6.1.1.9 "Aminoacyl-tRNA biosynthesis" XP_046753832.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046739841.1 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" XP_046747211.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046733882.1 6 Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.66;Reactome: R-HSA-1660516;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.66;MetaCyc: PWY-6368 "Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation" XP_046734739.1 2 KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10 "Glycine, serine and threonine metabolism";"One carbon pool by folate" XP_046744216.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046735525.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046744443.1 7 Reactome: R-HSA-165181;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-198323;Reactome: R-HSA-8854214;Reactome: R-HSA-380972;Reactome: R-HSA-5674400 "Inhibition of TSC complex formation by PKB";"Macroautophagy";"TP53 Regulates Metabolic Genes";"AKT phosphorylates targets in the cytosol";"TBC/RABGAPs";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer" XP_046734893.1 5 KEGG: 00270+6.3.2.3;Reactome: R-HSA-174403;KEGG: 00480+6.3.2.3;Reactome: R-HSA-5579006;MetaCyc: PWY-8043 "Cysteine and methionine metabolism";"Glutathione synthesis and recycling";"Glutathione metabolism";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Ophthalmate biosynthesis" XP_046739315.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046749285.1 6 MetaCyc: PWY-8004;KEGG: 00260+5.4.2.11;MetaCyc: PWY-5484;MetaCyc: PWY-1622;KEGG: 00680+5.4.2.11;KEGG: 00010+5.4.2.11 "Entner-Doudoroff pathway I";"Glycine, serine and threonine metabolism";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Glycolysis / Gluconeogenesis" XP_046753233.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046737355.1 4 Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664 "DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation" XP_046752252.1 3 KEGG: 00561+3.1.1.23;Reactome: R-HSA-426048;MetaCyc: PWY-7420 "Glycerolipid metabolism";"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)" XP_046748015.1 3 Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.4 "Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046737029.1 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" XP_046738082.1 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" XP_046734703.1 1 Reactome: R-HSA-977347 "Serine biosynthesis" XP_046739830.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046739779.1 4 Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257;Reactome: R-HSA-2470946 "Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin" XP_046750086.1 5 Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-6804758;Reactome: R-HSA-8943724 "HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"Regulation of TP53 Activity through Acetylation";"Regulation of PTEN gene transcription" XP_046736121.1 1 KEGG: 00970+6.1.1.2 "Aminoacyl-tRNA biosynthesis" XP_046747517.1 2 Reactome: R-HSA-975577;Reactome: R-HSA-2022854 "N-Glycan antennae elongation";"Keratan sulfate biosynthesis" XP_046752899.1 2 Reactome: R-HSA-162588;Reactome: R-HSA-917729 "Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)" XP_046752800.1 3 Reactome: R-HSA-727802;Reactome: R-HSA-5619078;Reactome: R-HSA-6787639 "Transport of nucleotide sugars";"Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)";"GDP-fucose biosynthesis" XP_046739753.1 3 Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-8963901 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Chylomicron remodeling" XP_046752426.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046743645.1 3 MetaCyc: PWY-6369;Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21 "Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system" XP_046748978.1 3 MetaCyc: PWY-7831;Reactome: R-HSA-9033807;MetaCyc: PWY-7833 "ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide";"ABO blood group biosynthesis";"Biosynthesis of Lewis epitopes (H. pylori)" XP_046744695.1 1 Reactome: R-HSA-4615885 "SUMOylation of DNA replication proteins" XP_046749161.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046752121.1 1 Reactome: R-HSA-72165 "mRNA Splicing - Minor Pathway" XP_046743433.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046739583.1 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" XP_046743559.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046753990.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046752037.1 5 Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288 "Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1" XP_046753970.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046739716.1 31 MetaCyc: PWY-7858;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-2426168;MetaCyc: PWY-5147;Reactome: R-HSA-163765;MetaCyc: PWY-5994;MetaCyc: PWY-7723;MetaCyc: PWY-7746;MetaCyc: PWY-5366;Reactome: R-HSA-199220;Reactome: R-HSA-9029558;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWY-6799;MetaCyc: PWY-5973;MetaCyc: PWY-4381;MetaCyc: PWY-7388;MetaCyc: PWY-5367;MetaCyc: PWY-5966-1;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5989;MetaCyc: PWYG-321;MetaCyc: PWY-6282;MetaCyc: PWY-6519;MetaCyc: PWY-8047;MetaCyc: PWY-5142;MetaCyc: PWY-6113;MetaCyc: PWY-7663;Reactome: R-HSA-75105;MetaCyc: PWY-5971;MetaCyc: PWY-7664 "(5Z)-dodecenoate biosynthesis II";"Biotin metabolism";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis I (plants)";"ChREBP activates metabolic gene expression";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Bacterial bioluminescence";"Mycobacterial sulfolipid biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Mupirocin biosynthesis";"Pederin biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"8-amino-7-oxononanoate biosynthesis I";"Bryostatin biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"Fatty acyl-CoA biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis IV (anaerobic)" XP_046753379.1 6 Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" XP_046735815.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046735383.1 5 Reactome: R-HSA-165181;Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-8854214 "Inhibition of TSC complex formation by PKB";"Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"TBC/RABGAPs" XP_046739193.1 2 Reactome: R-HSA-190873;Reactome: R-HSA-399719 "Gap junction degradation";"Trafficking of AMPA receptors" XP_046737836.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046737508.1 1 Reactome: R-HSA-9022692 "Regulation of MECP2 expression and activity" XP_046742545.1 1 Reactome: R-HSA-6807878 "COPI-mediated anterograde transport" XP_046753259.1 19 Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692;Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-9649948;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-438066;Reactome: R-HSA-5673000;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-6802952 "Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Signaling downstream of RAS mutants";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"RAF activation";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions" XP_046750569.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046744915.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046746088.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046743887.1 3 Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382 "RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex" XP_046748873.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" XP_046744598.1 6 Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-68962;Reactome: R-HSA-68949 "Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Unwinding of DNA";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex";"Orc1 removal from chromatin" XP_046746810.1 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" XP_046735559.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046741979.1 3 Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway" XP_046748039.1 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" XP_046739762.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046740068.1 6 Reactome: R-HSA-5654693;Reactome: R-HSA-5654706;Reactome: R-HSA-5654700;Reactome: R-HSA-5673001;Reactome: R-HSA-9028731;Reactome: R-HSA-5654712 "FRS-mediated FGFR1 signaling";"FRS-mediated FGFR3 signaling";"FRS-mediated FGFR2 signaling";"RAF/MAP kinase cascade";"Activated NTRK2 signals through FRS2 and FRS3";"FRS-mediated FGFR4 signaling" XP_046746532.1 2 Reactome: R-HSA-8854518;Reactome: R-HSA-6804756 "AURKA Activation by TPX2";"Regulation of TP53 Activity through Phosphorylation" XP_046735120.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046744429.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046751992.1 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" XP_046748432.1 3 Reactome: R-HSA-5083627;Reactome: R-HSA-2022854;Reactome: R-HSA-5173105 "Defective LARGE causes MDDGA6 and MDDGB6";"Keratan sulfate biosynthesis";"O-linked glycosylation" XP_046736942.1 6 Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" XP_046745330.1 2 Reactome: R-HSA-525793;Reactome: R-HSA-390648 "Myogenesis";"Muscarinic acetylcholine receptors" XP_046738520.1 2 Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58 "Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis" XP_046752811.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046735487.1 4 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046748286.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046745668.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046741999.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046740759.1 3 Reactome: R-HSA-6784531;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470 "tRNA processing in the nucleus";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion" XP_046743028.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046738495.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" XP_046740917.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046749547.1 5 Reactome: R-HSA-69473;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-5693607;Reactome: R-HSA-3232118 "G2/M DNA damage checkpoint";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Processing of DNA double-strand break ends";"SUMOylation of transcription factors" XP_046743106.1 5 Reactome: R-HSA-70895;KEGG: 00280+1.2.4.4;Reactome: R-HSA-389661;KEGG: 00640+1.2.4.4;MetaCyc: PWY-5046 "Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation";"Glyoxylate metabolism and glycine degradation";"Propanoate metabolism";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA" XP_046736992.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046747883.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046750043.1 6 MetaCyc: PWY-7920;Reactome: R-HSA-975578;Reactome: R-HSA-4793952;KEGG: 00510+2.4.1.143;MetaCyc: PWY-7426;KEGG: 00513+2.4.1.143 "Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Various types of N-glycan biosynthesis" XP_046738971.1 11 MetaCyc: PWY-6538;MetaCyc: PWY-6999;MetaCyc: PWY-6607;KEGG: 00230+1.17.1.4+1.17.3.2;MetaCyc: PWY-5695;KEGG: 00232+1.17.3.2;MetaCyc: PWY-5497;MetaCyc: PWY-6606;MetaCyc: PWY-6608;KEGG: 00983+1.17.3.2;MetaCyc: PWY-6596 "Caffeine degradation III (bacteria, via demethylation)";"Theophylline degradation";"Guanosine nucleotides degradation I";"Purine metabolism";"Inosine 5'-phosphate degradation";"Caffeine metabolism";"Purine nucleobases degradation II (anaerobic)";"Guanosine nucleotides degradation II";"Guanosine nucleotides degradation III";"Drug metabolism - other enzymes";"Adenosine nucleotides degradation I" XP_046752441.1 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" XP_046733835.1 6 Reactome: R-HSA-8986944;Reactome: R-HSA-2892245;Reactome: R-HSA-452723;Reactome: R-HSA-3769402;Reactome: R-HSA-2892247;Reactome: R-HSA-6785807 "Transcriptional Regulation by MECP2";"POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation";"Transcriptional regulation of pluripotent stem cells";"Deactivation of the beta-catenin transactivating complex";"POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation";"Interleukin-4 and Interleukin-13 signaling" XP_046744595.1 2 Reactome: R-HSA-204626;MetaCyc: PWY-5905 "Hypusine synthesis from eIF5A-lysine";"Hypusine biosynthesis" XP_046746215.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046739325.1 1 Reactome: R-HSA-389977 "Post-chaperonin tubulin folding pathway" XP_046748451.1 6 Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-6798695 "ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Ion channel transport";"Neutrophil degranulation" XP_046741140.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046737045.1 13 Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-975957 "SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046738776.1 10 MetaCyc: PWY-3821;MetaCyc: PWY-7344;Reactome: R-HSA-5609977;MetaCyc: PWY-6317;Reactome: R-HSA-70370;MetaCyc: PWY-6397;MetaCyc: PWY-6527;KEGG: 00052+5.1.3.2;MetaCyc: PWY-7328;KEGG: 00520+5.1.3.2 "D-galactose detoxification";"UDP-alpha-D-galactose biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose degradation I (Leloir pathway)";"Galactose catabolism";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Stachyose degradation";"Galactose metabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Amino sugar and nucleotide sugar metabolism" XP_046737056.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046751445.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046738471.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046736508.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046740185.1 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" XP_046741346.1 3 MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2 "Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism" XP_046743716.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046736264.1 3 Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340 "PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation" XP_046749039.1 9 KEGG: 04070+3.1.4.11;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351;MetaCyc: PWY-6367;MetaCyc: PWY-8052;Reactome: R-HSA-416476;Reactome: R-HSA-1855204;Reactome: R-HSA-112043 "Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"G alpha (q) signalling events";"Synthesis of IP3 and IP4 in the cytosol";"PLC beta mediated events" XP_046749440.1 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" XP_046746896.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046744904.1 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" XP_046749308.1 4 MetaCyc: PWY-5189;Reactome: R-HSA-189451;MetaCyc: PWY-5188;KEGG: 00860+4.2.1.75 "Tetrapyrrole biosynthesis II (from glycine)";"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism" XP_046741949.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046751304.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046746222.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046746537.1 1 Reactome: R-HSA-389957 "Prefoldin mediated transfer of substrate to CCT/TriC" XP_046742540.1 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" XP_046742906.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" XP_046743999.1 4 KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046751167.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046742960.1 3 KEGG: 00480+4.3.2.7;MetaCyc: PWY-7942;Reactome: R-HSA-174403 "Glutathione metabolism";"5-oxo-L-proline metabolism";"Glutathione synthesis and recycling" XP_046747548.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046747592.1 2 KEGG: 00450+2.7.9.3;MetaCyc: PWY-6281 "Selenocompound metabolism";"L-selenocysteine biosynthesis II (archaea and eukaryotes)" XP_046733716.1 52 Reactome: R-HSA-167172;Reactome: R-HSA-6781827;Reactome: R-HSA-9018519;Reactome: R-HSA-76066;Reactome: R-HSA-6796648;Reactome: R-HSA-75953;Reactome: R-HSA-73762;Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-76042;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-76071;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-75955;Reactome: R-HSA-6782210;Reactome: R-HSA-72203;Reactome: R-HSA-5617472;Reactome: R-HSA-77075;Reactome: R-HSA-6807505;Reactome: R-HSA-5578749;Reactome: R-HSA-73779;Reactome: R-HSA-76061;Reactome: R-HSA-427413;Reactome: R-HSA-203927;Reactome: R-HSA-674695;Reactome: R-HSA-73780;Reactome: R-HSA-73776;Reactome: R-HSA-167162;Reactome: R-HSA-5601884;Reactome: R-HSA-73772;Reactome: R-HSA-167246;Reactome: R-HSA-5250924;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-167238;Reactome: R-HSA-73980;Reactome: R-HSA-72163;Reactome: R-HSA-167161;Reactome: R-HSA-167287;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-72165;Reactome: R-HSA-113418;Reactome: R-HSA-8851708;Reactome: R-HSA-73863 "Transcription of the HIV genome";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Estrogen-dependent gene expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Initiation";"FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Processing of Capped Intron-Containing Pre-mRNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA polymerase II transcribes snRNA genes";"Transcriptional regulation by small RNAs";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"NoRC negatively regulates rRNA expression";"MicroRNA (miRNA) biogenesis";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase III Chain Elongation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase I Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"B-WICH complex positively regulates rRNA expression";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Termination";"mRNA Splicing - Major Pathway";"HIV Transcription Initiation";"HIV elongation arrest and recovery";"mRNA Capping";"Viral Messenger RNA Synthesis";"mRNA Splicing - Minor Pathway";"Formation of the Early Elongation Complex";"Signaling by FGFR2 IIIa TM";"RNA Polymerase I Transcription Termination" XP_046746688.1 16 Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226 "Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Peptide chain elongation";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046741925.1 14 MetaCyc: PWY-7725;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7724;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7035 "Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis" XP_046751034.1 11 Reactome: R-HSA-210455;KEGG: 00910+6.3.1.2;KEGG: 00220+6.3.1.2;MetaCyc: PWY-6964;MetaCyc: PWY-6963;MetaCyc: PWY-6549;Reactome: R-HSA-8964539;MetaCyc: PWY-5675;MetaCyc: PWY-381;KEGG: 00630+6.3.1.2;KEGG: 00250+6.3.1.2 "Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Nitrogen metabolism";"Arginine biosynthesis";"Ammonia assimilation cycle II";"Ammonia assimilation cycle I";"L-glutamine biosynthesis III";"Glutamate and glutamine metabolism";"Nitrate reduction V (assimilatory)";"Nitrate reduction II (assimilatory)";"Glyoxylate and dicarboxylate metabolism";"Alanine, aspartate and glutamate metabolism" XP_046737907.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046747485.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046746709.1 1 Reactome: R-HSA-525793 "Myogenesis" XP_046739258.1 2 KEGG: 00970+6.1.1.15;Reactome: R-HSA-379726 "Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" XP_046753324.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046742518.1 3 Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081 "Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling" XP_046745715.1 2 MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1 "S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism" XP_046752294.1 1 KEGG: 00970+6.1.1.19 "Aminoacyl-tRNA biosynthesis" XP_046748725.1 7 Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518 "Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2" XP_046753520.1 4 Reactome: R-HSA-499943;KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221;Reactome: R-HSA-2161541 "Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Abacavir metabolism" XP_046738573.1 3 Reactome: R-HSA-3899300;Reactome: R-HSA-6804757;Reactome: R-HSA-9609690 "SUMOylation of transcription cofactors";"Regulation of TP53 Degradation";"HCMV Early Events" XP_046751964.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046738738.1 16 Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702 "Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition" XP_046736388.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046741952.1 1 Reactome: R-HSA-426048 "Arachidonate production from DAG" XP_046734499.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046734911.1 2 Reactome: R-HSA-877312;Reactome: R-HSA-6807004 "Regulation of IFNG signaling";"Negative regulation of MET activity" XP_046737410.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046745138.1 7 MetaCyc: PWY-5686;MetaCyc: PWY-7790;MetaCyc: PWY-5697;KEGG: 00240+3.5.2.3;MetaCyc: PWY-7791;MetaCyc: PWY-5698;KEGG: 00230+3.5.2.5 "UMP biosynthesis I";"UMP biosynthesis II";"Allantoin degradation to ureidoglycolate I (urea producing)";"Pyrimidine metabolism";"UMP biosynthesis III";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"Purine metabolism" XP_046748445.1 2 Reactome: R-HSA-5339700;Reactome: R-HSA-4641265 "TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes" XP_046749984.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046740007.1 1 Reactome: R-HSA-3108214 "SUMOylation of DNA damage response and repair proteins" XP_046748701.1 6 MetaCyc: PWY-5381;MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+6.3.1.5;KEGG: 00760+6.3.5.1;MetaCyc: PWY-5653 "Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde" XP_046751411.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" XP_046736482.1 2 Reactome: R-HSA-977443;Reactome: R-HSA-1236394 "GABA receptor activation";"Signaling by ERBB4" XP_046737916.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046737222.1 1 Reactome: R-HSA-71064 "Lysine catabolism" XP_046735382.1 5 Reactome: R-HSA-8854214;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-165181 "TBC/RABGAPs";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Inhibition of TSC complex formation by PKB" XP_046738472.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046735983.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046744546.1 1 Reactome: R-HSA-5389840 "Mitochondrial translation elongation" XP_046744104.1 2 KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685 "Glutathione metabolism";"Detoxification of Reactive Oxygen Species" XP_046741088.1 4 Reactome: R-HSA-5693607;Reactome: R-HSA-5689880;Reactome: R-HSA-111465;Reactome: R-HSA-176187 "Processing of DNA double-strand break ends";"Ub-specific processing proteases";"Apoptotic cleavage of cellular proteins";"Activation of ATR in response to replication stress" XP_046735590.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046738902.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046743523.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046750440.1 1 Reactome: R-HSA-163560 "Triglyceride catabolism" XP_046735762.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046738047.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046738560.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046745340.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046748876.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046743394.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046738807.1 4 MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32 "Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism" XP_046752054.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046747525.1 4 MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-6902 "Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)" XP_046752659.1 5 Reactome: R-HSA-983168;Reactome: R-HSA-977225;Reactome: R-HSA-9646399;Reactome: R-HSA-5205685;Reactome: R-HSA-5689877 "Antigen processing: Ubiquitination & Proteasome degradation";"Amyloid fiber formation";"Aggrephagy";"Pink/Parkin Mediated Mitophagy";"Josephin domain DUBs" XP_046749454.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes" XP_046753554.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046748759.1 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" XP_046735922.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046740125.1 3 Reactome: R-HSA-5250924;Reactome: R-HSA-72165;Reactome: R-HSA-72163 "B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" XP_046747258.1 2 Reactome: R-HSA-8866654;Reactome: R-HSA-9033241 "E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import" XP_046746686.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046736740.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046735023.1 1 Reactome: R-HSA-5625900 "RHO GTPases activate CIT" XP_046752108.1 1 KEGG: 00010+5.1.3.15 "Glycolysis / Gluconeogenesis" XP_046751808.1 2 Reactome: R-HSA-400253;Reactome: R-HSA-2151201 "Circadian Clock";"Transcriptional activation of mitochondrial biogenesis" XP_046752962.1 6 Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958 "Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease" XP_046746093.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046741297.1 1 Reactome: R-HSA-1483148 "Synthesis of PG" XP_046753848.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046744176.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046748771.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046737896.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046746047.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046750187.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046735659.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046735148.1 1 Reactome: R-HSA-419771 "Opsins" XP_046750332.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046739338.1 7 Reactome: R-HSA-1483226;MetaCyc: PWY-7625;MetaCyc: PWY-6351;KEGG: 00562+2.7.8.11;KEGG: 00564+2.7.8.11;MetaCyc: PWY-6352;KEGG: 04070+2.7.8.11 "Synthesis of PI";"Phosphatidylinositol biosynthesis II (eukaryotes)";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism";"Glycerophospholipid metabolism";"3-phosphoinositide biosynthesis";"Phosphatidylinositol signaling system" XP_046747568.1 2 Reactome: R-HSA-73980;Reactome: R-HSA-749476 "RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation" XP_046744553.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046749876.1 1 KEGG: 00480+3.4.11.1 "Glutathione metabolism" XP_046741430.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" XP_046744236.1 7 Reactome: R-HSA-6804114;Reactome: R-HSA-1362300;Reactome: R-HSA-1538133;Reactome: R-HSA-69231;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-2173796 "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G0 and Early G1";"Cyclin D associated events in G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription" XP_046742314.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-6793080 "Transcriptional activation of mitochondrial biogenesis";"rRNA modification in the mitochondrion" XP_046746746.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046746317.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046746165.1 4 Reactome: R-HSA-212300;Reactome: R-HSA-5334118;Reactome: R-HSA-4655427;KEGG: 00270+2.1.1.37 "PRC2 methylates histones and DNA";"DNA methylation";"SUMOylation of DNA methylation proteins";"Cysteine and methionine metabolism" XP_046742362.1 4 KEGG: 00510+2.4.1.131;KEGG: 00513+2.4.1.131;Reactome: R-HSA-446193;Reactome: R-HSA-4551295 "N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG11 causes ALG11-CDG (CDG-1p)" XP_046749108.1 5 Reactome: R-HSA-5545619;Reactome: R-HSA-4641257;Reactome: R-HSA-5689880;Reactome: R-HSA-201681;Reactome: R-HSA-8948751 "XAV939 inhibits tankyrase, stabilizing AXIN";"Degradation of AXIN";"Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"Regulation of PTEN stability and activity" XP_046740329.1 6 Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-456926;Reactome: R-HSA-428930;Reactome: R-HSA-399997 "G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor";"Acetylcholine regulates insulin secretion" XP_046742356.1 2 Reactome: R-HSA-1268020;Reactome: R-HSA-8949613 "Mitochondrial protein import";"Cristae formation" XP_046739015.1 6 Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72649 "Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation" XP_046738329.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046749644.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046753662.1 2 Reactome: R-HSA-162791;Reactome: R-HSA-189085 "Attachment of GPI anchor to uPAR";"Digestion of dietary carbohydrate" XP_046744987.1 1 KEGG: 00450+1.8.1.9 "Selenocompound metabolism" XP_046749354.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046744549.1 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" XP_046734427.1 2 Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13 "RHO GTPases activate PKNs";"Phosphatidylinositol signaling system" XP_046742743.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046742005.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046750971.1 1 Reactome: R-HSA-425366 "Transport of bile salts and organic acids, metal ions and amine compounds" XP_046737188.1 4 KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174;Reactome: R-HSA-72731;MetaCyc: PWY-4361 "Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Recycling of eIF2:GDP";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I" XP_046745595.1 8 Reactome: R-HSA-6798695;MetaCyc: PWY-7179-1;Reactome: R-HSA-5683826;KEGG: 00230+3.5.4.4;MetaCyc: PWY-6609;MetaCyc: PWY-6611;MetaCyc: PWY-7179;Reactome: R-HSA-74217 "Neutrophil degranulation";"Purine deoxyribonucleosides degradation II";"Surfactant metabolism";"Purine metabolism";"Adenine and adenosine salvage III";"Adenine and adenosine salvage V";"Purine deoxyribonucleosides degradation I";"Purine salvage" XP_046739758.1 4 Reactome: R-HSA-176187;Reactome: R-HSA-69205;Reactome: R-HSA-176974;Reactome: R-HSA-68962 "Activation of ATR in response to replication stress";"G1/S-Specific Transcription";"Unwinding of DNA";"Activation of the pre-replicative complex" XP_046733765.1 14 MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7725;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598 "Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis" XP_046747012.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046748462.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046747424.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046737312.1 14 KEGG: 00600+3.1.3.4;KEGG: 00564+3.1.3.4;KEGG: 00561+3.1.3.4;Reactome: R-HSA-75109;Reactome: R-HSA-1483191;MetaCyc: PWY-8051;MetaCyc: PWY-8052;MetaCyc: PWY-6453;KEGG: 00565+3.1.3.4;MetaCyc: PWY-7782;Reactome: R-HSA-4419969;Reactome: R-HSA-1483213;MetaCyc: PWY-8053;MetaCyc: PWY-8055 "Sphingolipid metabolism";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Triglyceride biosynthesis";"Synthesis of PC";"Anandamide biosynthesis I";"2-arachidonoylglycerol biosynthesis";"Stigma estolide biosynthesis";"Ether lipid metabolism";"Plasmalogen biosynthesis";"Depolymerisation of the Nuclear Lamina";"Synthesis of PE";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis" XP_046740181.1 3 Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160 "VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway";"Signal regulatory protein family interactions" XP_046750402.1 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" XP_046739337.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046749159.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046749259.1 1 KEGG: 00970+6.1.1.22 "Aminoacyl-tRNA biosynthesis" XP_046738774.1 10 MetaCyc: PWY-7344;MetaCyc: PWY-3821;MetaCyc: PWY-6527;MetaCyc: PWY-6397;MetaCyc: PWY-7328;KEGG: 00052+5.1.3.2;KEGG: 00520+5.1.3.2;Reactome: R-HSA-5609977;Reactome: R-HSA-70370;MetaCyc: PWY-6317 "UDP-alpha-D-galactose biosynthesis";"D-galactose detoxification";"Stachyose degradation";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Galactose catabolism";"D-galactose degradation I (Leloir pathway)" XP_046745194.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046742222.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046750010.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046753852.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046753518.1 4 Reactome: R-HSA-499943;Reactome: R-HSA-2161541;MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Interconversion of nucleotide di- and triphosphates";"Abacavir metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046746967.1 3 MetaCyc: PWY-6689;MetaCyc: PWY-7803;Reactome: R-HSA-6784531 "Trna splicing I";"Trna splicing II";"tRNA processing in the nucleus" XP_046748257.1 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" XP_046751672.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046753594.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046744694.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046733910.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046746496.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046736804.1 10 KEGG: 00051+2.7.1.11;Reactome: R-HSA-70171;KEGG: 00052+2.7.1.11;KEGG: 00010+2.7.1.11;MetaCyc: PWY-1861;KEGG: 00030+2.7.1.11;KEGG: 00680+2.7.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-7385 "Fructose and mannose metabolism";"Glycolysis";"Galactose metabolism";"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)" XP_046745985.1 1 Reactome: R-HSA-426486 "Small interfering RNA (siRNA) biogenesis" XP_046751663.1 3 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046734524.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046734677.1 3 Reactome: R-HSA-9603798;Reactome: R-HSA-8866654;Reactome: R-HSA-9033241 "Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import" XP_046752413.1 9 KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52 "Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Chitin degradation III (Serratia)";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis" XP_046737004.1 17 Reactome: R-HSA-1362277;Reactome: R-HSA-139915;Reactome: R-HSA-69205;Reactome: R-HSA-6804114;Reactome: R-HSA-111448;Reactome: R-HSA-1362300;Reactome: R-HSA-113501;Reactome: R-HSA-1538133;Reactome: R-HSA-69231;Reactome: R-HSA-2559580;Reactome: R-HSA-69656;Reactome: R-HSA-2173796;Reactome: R-HSA-8953750;Reactome: R-HSA-1912408;Reactome: R-HSA-9616222;Reactome: R-HSA-2559585;Reactome: R-HSA-69202 "Transcription of E2F targets under negative control by DREAM complex";"Activation of PUMA and translocation to mitochondria";"G1/S-Specific Transcription";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Activation of NOXA and translocation to mitochondria";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"G0 and Early G1";"Cyclin D associated events in G1";"Oxidative Stress Induced Senescence";"Cyclin A:Cdk2-associated events at S phase entry";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Transcriptional Regulation by E2F6";"Pre-NOTCH Transcription and Translation";"Transcriptional regulation of granulopoiesis";"Oncogene Induced Senescence";"Cyclin E associated events during G1/S transition" XP_046738169.1 7 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-4615885;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"SUMOylation of DNA replication proteins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046741337.1 10 Reactome: R-HSA-9022702;Reactome: R-HSA-9022538;Reactome: R-HSA-9022699;Reactome: R-HSA-3899300;Reactome: R-HSA-8936459;Reactome: R-HSA-9022692;Reactome: R-HSA-427413;Reactome: R-HSA-983231;Reactome: R-HSA-9615017;Reactome: R-HSA-400206 "MECP2 regulates transcription of neuronal ligands";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates neuronal receptors and channels";"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha" XP_046747006.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046742166.1 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" XP_046752146.1 6 MetaCyc: PWY-6317;Reactome: R-HSA-70370;Reactome: R-HSA-5609978;KEGG: 00520+2.7.7.12;KEGG: 00052+2.7.7.12;MetaCyc: PWY-6527 "D-galactose degradation I (Leloir pathway)";"Galactose catabolism";"Defective GALT can cause Galactosemia";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Stachyose degradation" XP_046735055.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046744103.1 9 MetaCyc: PWY-5981;MetaCyc: PWY-7411;KEGG: 00564+1.1.1.94;Reactome: R-HSA-1483166;MetaCyc: PWY-7385;MetaCyc: PWY-7902;MetaCyc: PWY-6118;MetaCyc: PWY-5667;KEGG: 00564+1.1.1.8 "CDP-diacylglycerol biosynthesis III";"Phosphatidate biosynthesis (yeast)";"Glycerophospholipid metabolism";"Synthesis of PA";"1,3-propanediol biosynthesis (engineered)";"Glucosylglycerol biosynthesis";"Glycerol-3-phosphate shuttle";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism" XP_046735308.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046737647.1 9 Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-674695 "RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events" XP_046749582.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport" XP_046748124.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046733827.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046738906.1 14 KEGG: 00591+3.1.1.4;Reactome: R-HSA-975634;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-6803;Reactome: R-HSA-1482788;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-7417;MetaCyc: PWY-7416;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4 "Linoleic acid metabolism";"Retinoid metabolism and transport";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PC";"Glycerophospholipid metabolism";"Arachidonic acid metabolism";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism" XP_046742606.1 5 Reactome: R-HSA-174490;Reactome: R-HSA-162588;Reactome: R-HSA-917729;Reactome: R-HSA-9615710;Reactome: R-HSA-9610379 "Membrane binding and targetting of GAG proteins";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy";"HCMV Late Events" XP_046751020.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046746217.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046738087.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046742398.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046734503.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046749907.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046743672.1 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" XP_046734392.1 17 Reactome: R-HSA-69183;Reactome: R-HSA-174414;Reactome: R-HSA-69091;Reactome: R-HSA-5696400;Reactome: R-HSA-5696397;Reactome: R-HSA-174437;Reactome: R-HSA-5358606;Reactome: R-HSA-6782210;Reactome: R-HSA-69166;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-5358565;Reactome: R-HSA-5656169;Reactome: R-HSA-6782135;Reactome: R-HSA-174417;Reactome: R-HSA-174411;Reactome: R-HSA-5651801 "Processive synthesis on the lagging strand";"Processive synthesis on the C-strand of the telomere";"Polymerase switching";"Dual Incision in GG-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Removal of the Flap Intermediate from the C-strand";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Removal of the Flap Intermediate";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Termination of translesion DNA synthesis";"Dual incision in TC-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair" XP_046738491.1 3 Reactome: R-HSA-1810476;Reactome: R-HSA-445989;Reactome: R-HSA-933542 "RIP-mediated NFkB activation via ZBP1";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TRAF6 mediated NF-kB activation" XP_046744183.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046752928.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046752629.1 12 KEGG: 00920+2.7.1.25;KEGG: 00920+2.7.7.4;KEGG: 00261+2.7.7.4;Reactome: R-HSA-2408550;MetaCyc: PWY-6932;MetaCyc: PWY-5340;KEGG: 00450+2.7.7.4;KEGG: 00230+2.7.1.25;KEGG: 00230+2.7.7.4;MetaCyc: PWY-5278;Reactome: R-HSA-174362;MetaCyc: PWY-6683 "Sulfur metabolism";"Sulfur metabolism";"Monobactam biosynthesis";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Selenate reduction";"Sulfate activation for sulfonation";"Selenocompound metabolism";"Purine metabolism";"Purine metabolism";"Sulfite oxidation III";"Transport and synthesis of PAPS";"Assimilatory sulfate reduction III" XP_046740996.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046752706.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" XP_046745276.1 5 Reactome: R-HSA-936964;Reactome: R-HSA-937041;Reactome: R-HSA-166166;Reactome: R-HSA-168164;Reactome: R-HSA-937072 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1";"MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex" XP_046753288.1 57 Reactome: R-HSA-1236974;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-450408;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-382556;Reactome: R-HSA-8939902;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880 "ER-Phagosome pathway";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of AXIN";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"ABC-family proteins mediated transport";"Regulation of RUNX2 expression and activity";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases" XP_046747162.1 5 Reactome: R-HSA-2395516;Reactome: R-HSA-211976;Reactome: R-HSA-196108;Reactome: R-HSA-1362409;Reactome: R-HSA-5579026 "Electron transport from NADPH to Ferredoxin";"Endogenous sterols";"Pregnenolone biosynthesis";"Mitochondrial iron-sulfur cluster biogenesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)" XP_046753225.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046743561.1 2 Reactome: R-HSA-1663150;Reactome: R-HSA-1660662 "The activation of arylsulfatases";"Glycosphingolipid metabolism" XP_046740506.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046747625.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-5357905 "RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling" XP_046739531.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046736575.1 2 Reactome: R-HSA-6803205;Reactome: R-HSA-8873719 "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"RAB geranylgeranylation" XP_046738579.1 6 KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23;MetaCyc: PWY-6807 "Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Galactose metabolism";"Xyloglucan degradation II (exoglucanase)" XP_046739722.1 5 Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-6804757;Reactome: R-HSA-1257604 "Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"Regulation of TP53 Degradation";"PIP3 activates AKT signaling" XP_046745500.1 7 Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288 "mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTOR signalling";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1" XP_046743731.1 33 Reactome: R-HSA-1169408;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-5619107;Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-159227;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-191859;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-9648025;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-159230;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-5578749;Reactome: R-HSA-5663220;Reactome: R-HSA-159231;Reactome: R-HSA-168271;Reactome: R-HSA-2500257;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-141444;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379 "ISG15 antiviral mechanism";"Nuclear import of Rev protein";"Mitotic Prometaphase";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP independent Mature mRNA";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"snRNP Assembly";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transcriptional regulation by small RNAs";"RHO GTPases Activate Formins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Resolution of Sister Chromatid Cohesion";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"HCMV Late Events" XP_046749664.1 10 MetaCyc: PWY-6366;MetaCyc: PWY-6365;MetaCyc: PWY-6362;Reactome: R-HSA-983231;KEGG: 00562+2.7.1.134+2.7.1.159;Reactome: R-HSA-1855204;Reactome: R-HSA-1855167;MetaCyc: PWY-6554;MetaCyc: PWY-4661;KEGG: 04070+2.7.1.159 "D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis";"D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Factors involved in megakaryocyte development and platelet production";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Phosphatidylinositol signaling system" XP_046738144.1 1 Reactome: R-HSA-201451 "Signaling by BMP" XP_046749023.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046740478.1 12 MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7417;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4 "Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Linoleic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism" XP_046751424.1 14 MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5981;MetaCyc: PWY-7417;MetaCyc: PWY-8053;MetaCyc: PWY-8055;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7589;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-6453;MetaCyc: PWY-8051 "Plasmalogen biosynthesis";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Glycerophospholipid metabolism";"Palmitoleate biosynthesis III (cyanobacteria)";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Stigma estolide biosynthesis";"Anandamide biosynthesis I" XP_046735468.1 2 Reactome: R-HSA-71403;Reactome: R-HSA-611105 "Citric acid cycle (TCA cycle)";"Respiratory electron transport" XP_046741152.1 3 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" XP_046735331.1 8 Reactome: R-HSA-174411;Reactome: R-HSA-68962;Reactome: R-HSA-113501;Reactome: R-HSA-174430;Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-69183;Reactome: R-HSA-69166 "Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Telomere C-strand synthesis initiation";"Polymerase switching";"DNA replication initiation";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate" XP_046752144.1 1 Reactome: R-HSA-947581 "Molybdenum cofactor biosynthesis" XP_046746166.1 4 KEGG: 00270+2.1.1.37;Reactome: R-HSA-212300;Reactome: R-HSA-5334118;Reactome: R-HSA-4655427 "Cysteine and methionine metabolism";"PRC2 methylates histones and DNA";"DNA methylation";"SUMOylation of DNA methylation proteins" XP_046743073.1 2 Reactome: R-HSA-72706;Reactome: R-HSA-72702 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition" XP_046751968.1 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" XP_046753566.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046752815.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway" XP_046742137.1 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" XP_046752051.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046747464.1 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" XP_046746779.1 29 Reactome: R-HSA-113418;Reactome: R-HSA-5696400;Reactome: R-HSA-73863;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-167161;Reactome: R-HSA-6782210;Reactome: R-HSA-72086;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-73772;Reactome: R-HSA-167162;Reactome: R-HSA-112382;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-167246;Reactome: R-HSA-76042;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-6781827;Reactome: R-HSA-77075;Reactome: R-HSA-73776;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-674695;Reactome: R-HSA-6796648 "Formation of the Early Elongation Complex";"Dual Incision in GG-NER";"RNA Polymerase I Transcription Termination";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV Transcription Initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Capping";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"RNA Polymerase I Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"Formation of RNA Pol II elongation complex";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes" XP_046748991.1 1 Reactome: R-HSA-8964038 "LDL clearance" XP_046744627.1 10 Reactome: R-HSA-2024096;KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;Reactome: R-HSA-6798695;Reactome: R-HSA-2206292;Reactome: R-HSA-2160916;MetaCyc: PWY-6807;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23 "HS-GAG degradation";"Glycosaminoglycan degradation";"Other glycan degradation";"Sphingolipid metabolism";"Neutrophil degranulation";"MPS VII - Sly syndrome";"Hyaluronan uptake and degradation";"Xyloglucan degradation II (exoglucanase)";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series" XP_046737961.1 3 Reactome: R-HSA-4608870;Reactome: R-HSA-420029;Reactome: R-HSA-2173791 "Asymmetric localization of PCP proteins";"Tight junction interactions";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" XP_046748853.1 13 KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-7226;KEGG: 00983+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7222;Reactome: R-HSA-499943;MetaCyc: PWY-7184;MetaCyc: PWY-7210 "Purine metabolism";"Glutathione metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP" XP_046751017.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046748252.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046741390.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" XP_046739929.1 7 KEGG: 00521+3.1.3.25;MetaCyc: PWY-4702;KEGG: 04070+3.1.3.25;Reactome: R-HSA-1855183;MetaCyc: PWY-2301;KEGG: 00562+3.1.3.25;MetaCyc: PWY-6363 "Streptomycin biosynthesis";"Phytate degradation I";"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate degradation" XP_046744651.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046741659.1 2 Reactome: R-HSA-525793;Reactome: R-HSA-373752 "Myogenesis";"Netrin-1 signaling" XP_046742148.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-8953750 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Transcriptional Regulation by E2F6" XP_046744944.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046751957.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046735466.1 2 Reactome: R-HSA-71403;Reactome: R-HSA-611105 "Citric acid cycle (TCA cycle)";"Respiratory electron transport" XP_046736173.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046741634.1 1 Reactome: R-HSA-427652 "Sodium-coupled phosphate cotransporters" XP_046753212.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" XP_046745880.1 1 Reactome: R-HSA-211981 "Xenobiotics" XP_046751766.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046751287.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046748281.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046744692.1 20 Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-69473;Reactome: R-HSA-110320;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-6782210;Reactome: R-HSA-5696397;Reactome: R-HSA-5693616;Reactome: R-HSA-6782135;Reactome: R-HSA-5656121;Reactome: R-HSA-5656169;Reactome: R-HSA-110314;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-5685938;Reactome: R-HSA-5655862 "Dual Incision in GG-NER";"Polymerase switching";"G2/M DNA damage checkpoint";"Translesion Synthesis by POLH";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Dual incision in TC-NER";"Translesion synthesis by POLI";"Termination of translesion DNA synthesis";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Single Strand Annealing (SSA)";"Translesion synthesis by POLK" XP_046746298.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046751481.1 4 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-76071 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" XP_046735157.1 13 Reactome: R-HSA-74259;KEGG: 00230+3.6.1.66;MetaCyc: PWY-7206;MetaCyc: PWY-6545;KEGG: 00240+3.6.1.9;KEGG: 00230+3.6.1.9;KEGG: 00770+3.6.1.9;MetaCyc: PWY-7821;KEGG: 00500+3.6.1.9;KEGG: 00760+3.6.1.9;MetaCyc: PWY-7184;KEGG: 00740+3.6.1.9;MetaCyc: PWY-7187 "Purine catabolism";"Purine metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Purine metabolism";"Pantothenate and CoA biosynthesis";"Tunicamycin biosynthesis";"Starch and sucrose metabolism";"Nicotinate and nicotinamide metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Riboflavin metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II" XP_046741401.1 6 KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463 "Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis" XP_046738132.1 2 Reactome: R-HSA-202733;Reactome: R-HSA-416993 "Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors" XP_046746000.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046735287.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046736381.1 4 Reactome: R-HSA-6790901;Reactome: R-HSA-72764;Reactome: R-HSA-156581;Reactome: R-HSA-6782315 "rRNA modification in the nucleus and cytosol";"Eukaryotic Translation Termination";"Methylation";"tRNA modification in the nucleus and cytosol" XP_046753262.1 4 MetaCyc: PWY-6557;Reactome: R-HSA-1971475;KEGG: 00532+2.4.2.26;KEGG: 00534+2.4.2.26 "Glycosaminoglycan-protein linkage region biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin" XP_046742810.1 7 Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-2122948 "NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Activated NOTCH1 Transmits Signal to the Nucleus" XP_046747881.1 6 Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-450385;Reactome: R-HSA-380994 "KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress" XP_046744943.1 4 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-1912420 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Pre-NOTCH Processing in Golgi" XP_046740339.1 16 Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702 "Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition" XP_046749029.1 7 KEGG: 00220+3.5.3.1;Reactome: R-HSA-70635;MetaCyc: PWY-4984;MetaCyc: PWY-6922;MetaCyc: PWY-31;MetaCyc: PWY-46;KEGG: 00330+3.5.3.1 "Arginine biosynthesis";"Urea cycle";"Urea cycle";"L-Ndelta-acetylornithine biosynthesis";"Canavanine degradation";"Putrescine biosynthesis III";"Arginine and proline metabolism" XP_046738706.1 10 Reactome: R-HSA-201688;Reactome: R-HSA-6814122;Reactome: R-HSA-2514853;Reactome: R-HSA-1483191;Reactome: R-HSA-8948751;Reactome: R-HSA-6804756;Reactome: R-HSA-8934903;Reactome: R-HSA-8939243;Reactome: R-HSA-6798695;Reactome: R-HSA-445144 "WNT mediated activation of DVL";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Condensation of Prometaphase Chromosomes";"Synthesis of PC";"Regulation of PTEN stability and activity";"Regulation of TP53 Activity through Phosphorylation";"Receptor Mediated Mitophagy";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Neutrophil degranulation";"Signal transduction by L1" XP_046742913.1 2 Reactome: R-HSA-2142691;Reactome: R-HSA-2142700 "Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)" XP_046745317.1 14 Reactome: R-HSA-203927;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-9018519;Reactome: R-HSA-426496;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-8934593;Reactome: R-HSA-5628897;Reactome: R-HSA-426486;Reactome: R-HSA-9029569 "MicroRNA (miRNA) biogenesis";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Estrogen-dependent gene expression";"Post-transcriptional silencing by small RNAs";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Regulation of RUNX1 Expression and Activity";"TP53 Regulates Metabolic Genes";"Small interfering RNA (siRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" XP_046747131.1 15 Reactome: R-HSA-167238;Reactome: R-HSA-9018519;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-2173796;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-176034;Reactome: R-HSA-167246;Reactome: R-HSA-167243 "Pausing and recovery of Tat-mediated HIV elongation";"Estrogen-dependent gene expression";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Interactions of Tat with host cellular proteins";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery" XP_046750382.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046749055.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046753945.1 1 Reactome: R-HSA-8849932 "Synaptic adhesion-like molecules" XP_046737418.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression" XP_046747264.1 2 Reactome: R-HSA-195253;Reactome: R-HSA-5689896 "Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases" XP_046740630.1 1 Reactome: R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" XP_046741817.1 3 MetaCyc: PWY-7511;Reactome: R-HSA-110314;Reactome: R-HSA-8866654 "Protein ubiquitination";"Recognition of DNA damage by PCNA-containing replication complex";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046744120.1 2 Reactome: R-HSA-425393;Reactome: R-HSA-5223345 "Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events" XP_046749646.1 1 Reactome: R-HSA-5689901 "Metalloprotease DUBs" XP_046747321.1 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" XP_046746152.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-5689880 "Protein ubiquitination";"Ub-specific processing proteases" XP_046734381.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046745501.1 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" XP_046743703.1 2 Reactome: R-HSA-1268020;Reactome: R-HSA-71403 "Mitochondrial protein import";"Citric acid cycle (TCA cycle)" XP_046752842.1 3 KEGG: 00790+6.3.2.17;Reactome: R-HSA-196757;MetaCyc: PWY-2161 "Folate biosynthesis";"Metabolism of folate and pterines";"Folate polyglutamylation" XP_046736686.1 4 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription" XP_046741661.1 2 Reactome: R-HSA-373752;Reactome: R-HSA-525793 "Netrin-1 signaling";"Myogenesis" XP_046737696.1 4 KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.32 "alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism" XP_046737898.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046752213.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046750113.1 1 Reactome: R-HSA-1483191 "Synthesis of PC" XP_046741202.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046749645.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046754032.1 10 Reactome: R-HSA-8856828;Reactome: R-HSA-8875360;Reactome: R-HSA-9635644;Reactome: R-HSA-6807004;Reactome: R-HSA-182971;Reactome: R-HSA-5689880;Reactome: R-HSA-432720;Reactome: R-HSA-8856825;Reactome: R-HSA-917729;Reactome: R-HSA-9636383 "Clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Inhibition of membrane repair";"Negative regulation of MET activity";"EGFR downregulation";"Ub-specific processing proteases";"Lysosome Vesicle Biogenesis";"Cargo recognition for clathrin-mediated endocytosis";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Prevention of phagosomal-lysosomal fusion" XP_046741099.1 1 Reactome: R-HSA-211897 "Cytochrome P450 - arranged by substrate type" XP_046744267.1 12 Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399 "COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy" XP_046743648.1 3 MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167 "Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol" XP_046745430.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase" XP_046739212.1 3 Reactome: R-HSA-446193;Reactome: R-HSA-4724289;KEGG: 00510+2.4.1.267 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG6 causes ALG6-CDG (CDG-1c)";"N-Glycan biosynthesis" XP_046748741.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046751616.1 2 Reactome: R-HSA-171319;Reactome: R-HSA-201722 "Telomere Extension By Telomerase";"Formation of the beta-catenin:TCF transactivating complex" XP_046751806.1 2 Reactome: R-HSA-400253;Reactome: R-HSA-2151201 "Circadian Clock";"Transcriptional activation of mitochondrial biogenesis" XP_046745631.1 4 Reactome: R-HSA-400511;Reactome: R-HSA-381771;Reactome: R-HSA-422085;Reactome: R-HSA-1799339 "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and deacylation of Ghrelin";"SRP-dependent cotranslational protein targeting to membrane" XP_046736726.1 7 Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes" XP_046736711.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046746897.1 7 Reactome: R-HSA-5663213;Reactome: R-HSA-418885;Reactome: R-HSA-2029482;Reactome: R-HSA-373753;Reactome: R-HSA-203641;Reactome: R-HSA-8856828;Reactome: R-HSA-3928662 "RHO GTPases Activate WASPs and WAVEs";"DCC mediated attractive signaling";"Regulation of actin dynamics for phagocytic cup formation";"Nephrin family interactions";"NOSTRIN mediated eNOS trafficking";"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling" XP_046734325.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046742394.1 3 KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348 "Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition" XP_046750153.1 2 Reactome: R-HSA-68962;Reactome: R-HSA-176187 "Activation of the pre-replicative complex";"Activation of ATR in response to replication stress" XP_046737393.1 2 Reactome: R-HSA-5250971;Reactome: R-HSA-5682910 "Toxicity of botulinum toxin type C (BoNT/C)";"LGI-ADAM interactions" XP_046742725.1 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" XP_046749875.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046741193.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046736429.1 4 Reactome: R-HSA-1799339;Reactome: R-HSA-879415;Reactome: R-HSA-6798695;Reactome: R-HSA-446203 "SRP-dependent cotranslational protein targeting to membrane";"Advanced glycosylation endproduct receptor signaling";"Neutrophil degranulation";"Asparagine N-linked glycosylation" XP_046745836.1 6 KEGG: 00564+1.1.5.3;MetaCyc: PWY-6118;MetaCyc: PWY-6952;Reactome: R-HSA-163560;Reactome: R-HSA-1483166;MetaCyc: PWY-4261 "Glycerophospholipid metabolism";"Glycerol-3-phosphate shuttle";"Glycerophosphodiester degradation";"Triglyceride catabolism";"Synthesis of PA";"Glycerol degradation I" XP_046750094.1 2 Reactome: R-HSA-9627069;Reactome: R-HSA-111458 "Regulation of the apoptosome activity";"Formation of apoptosome" XP_046750898.1 3 Reactome: R-HSA-1358803;Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046742797.1 1 Reactome: R-HSA-201681 "TCF dependent signaling in response to WNT" XP_046751083.1 7 Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-76061 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" XP_046749369.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046736753.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046737889.1 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" XP_046739836.1 4 Reactome: R-HSA-5250958;Reactome: R-HSA-6794361;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Toxicity of botulinum toxin type B (BoNT/B)";"Neurexins and neuroligins";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046733837.1 5 Reactome: R-HSA-5685939;Reactome: R-HSA-6782210;Reactome: R-HSA-5649702;Reactome: R-HSA-5696397;Reactome: R-HSA-110381 "HDR through MMEJ (alt-NHEJ)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Resolution of AP sites via the single-nucleotide replacement pathway" XP_046753918.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046736720.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046744815.1 5 Reactome: R-HSA-6804758;Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-427389 "Regulation of TP53 Activity through Acetylation";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" XP_046750489.1 3 Reactome: R-HSA-114508;KEGG: 04070+2.7.11.13;Reactome: R-HSA-418597 "Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"G alpha (z) signalling events" XP_046751193.1 5 Reactome: R-HSA-204005;Reactome: R-HSA-2132295;Reactome: R-HSA-1655829;Reactome: R-HSA-983170;Reactome: R-HSA-5694530 "COPII-mediated vesicle transport";"MHC class II antigen presentation";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Cargo concentration in the ER" XP_046735093.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046745499.1 7 Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-1632852 "Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Macroautophagy" XP_046749992.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046747318.1 26 Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-389977;Reactome: R-HSA-9648025;Reactome: R-HSA-389960;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295 "Mitotic Prometaphase";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"COPI-mediated anterograde transport";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Post-chaperonin tubulin folding pathway";"EML4 and NUDC in mitotic spindle formation";"Formation of tubulin folding intermediates by CCT/TriC";"Cilium Assembly";"Separation of Sister Chromatids";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases activate IQGAPs";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation" XP_046746171.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046745543.1 57 Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-174113;Reactome: R-HSA-6798695;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-450408;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-1236974;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684;Reactome: R-HSA-983168;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702 "Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"SCF-beta-TrCP mediated degradation of Emi1";"Neutrophil degranulation";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Degradation of AXIN";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"ER-Phagosome pathway";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Degradation of DVL";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling" XP_046743793.1 3 Reactome: R-HSA-430039;Reactome: R-HSA-450513;Reactome: R-HSA-450385 "mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" XP_046752824.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046740061.1 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" XP_046741859.1 11 Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-3214847;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-5689880;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-167161 "RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HATs acetylate histones";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"Ub-specific processing proteases";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation" XP_046753909.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046753050.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046749446.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046736323.1 2 Reactome: R-HSA-1483166;Reactome: R-HSA-1483148 "Synthesis of PA";"Synthesis of PG" XP_046747782.1 26 Reactome: R-HSA-6782135;Reactome: R-HSA-5358565;Reactome: R-HSA-5656121;Reactome: R-HSA-5656169;Reactome: R-HSA-110312;Reactome: R-HSA-110314;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-6804114;Reactome: R-HSA-5685942;Reactome: R-HSA-69166;Reactome: R-HSA-8866654;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-5655862;Reactome: R-HSA-174417;Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-110320;Reactome: R-HSA-69183;Reactome: R-HSA-174414;Reactome: R-HSA-6782210;Reactome: R-HSA-5358606;Reactome: R-HSA-174437;Reactome: R-HSA-4615885;Reactome: R-HSA-5696397 "Dual incision in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion synthesis by POLI";"Termination of translesion DNA synthesis";"Translesion synthesis by REV1";"Recognition of DNA damage by PCNA-containing replication complex";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate";"E3 ubiquitin ligases ubiquitinate target proteins";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by POLK";"Telomere C-strand (Lagging Strand) Synthesis";"Dual Incision in GG-NER";"Polymerase switching";"Translesion Synthesis by POLH";"Processive synthesis on the lagging strand";"Processive synthesis on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Removal of the Flap Intermediate from the C-strand";"SUMOylation of DNA replication proteins";"Gap-filling DNA repair synthesis and ligation in GG-NER" XP_046746953.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046739171.1 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" XP_046749380.1 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" XP_046751973.1 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" XP_046740992.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046743518.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046747157.1 2 Reactome: R-HSA-6807878;Reactome: R-HSA-6811434 "COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046741549.1 5 Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;KEGG: 00534+2.4.1.224+2.4.1.225;MetaCyc: PWY-6558;Reactome: R-HSA-3656253 "Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Heparan sulfate biosynthesis (late stages)";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS" XP_046738933.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046748996.1 4 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-375165;Reactome: R-HSA-5673001 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade" XP_046743341.1 5 Reactome: R-HSA-389661;MetaCyc: PWY-5084;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2 "Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Lysine degradation";"Tryptophan metabolism";"Citrate cycle (TCA cycle)" XP_046737951.1 6 MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656;Reactome: R-HSA-9640463 "Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis" XP_046746675.1 11 MetaCyc: PWY-5659;MetaCyc: PWY-882;MetaCyc: PWY-7586;MetaCyc: PWY-3881;KEGG: 00051+5.3.1.8;Reactome: R-HSA-446205;MetaCyc: PWY-7456;Reactome: R-HSA-4043916;KEGG: 00520+5.3.1.8;MetaCyc: PWY-6992;MetaCyc: PWY-3861 "GDP-mannose biosynthesis";"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Mannitol biosynthesis";"Fructose and mannose metabolism";"Synthesis of GDP-mannose";"Beta-(1,4)-mannan degradation";"Defective MPI causes MPI-CDG (CDG-1b)";"Amino sugar and nucleotide sugar metabolism";"1,5-anhydrofructose degradation";"Mannitol degradation II" XP_046743739.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046745350.1 2 Reactome: R-HSA-8853659;Reactome: R-HSA-5673001 "RET signaling";"RAF/MAP kinase cascade" XP_046753897.1 2 MetaCyc: PWY-5344;KEGG: 00270+2.3.1.31 "L-homocysteine biosynthesis";"Cysteine and methionine metabolism" XP_046750832.1 52 Reactome: R-HSA-72163;Reactome: R-HSA-167238;Reactome: R-HSA-73980;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-167287;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-113418;Reactome: R-HSA-72165;Reactome: R-HSA-73863;Reactome: R-HSA-6807505;Reactome: R-HSA-73779;Reactome: R-HSA-5578749;Reactome: R-HSA-5617472;Reactome: R-HSA-77075;Reactome: R-HSA-73776;Reactome: R-HSA-73780;Reactome: R-HSA-203927;Reactome: R-HSA-674695;Reactome: R-HSA-427413;Reactome: R-HSA-76061;Reactome: R-HSA-73772;Reactome: R-HSA-5601884;Reactome: R-HSA-167162;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-5250924;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-76071;Reactome: R-HSA-72203;Reactome: R-HSA-6782210;Reactome: R-HSA-75955;Reactome: R-HSA-167242;Reactome: R-HSA-167200;Reactome: R-HSA-76066;Reactome: R-HSA-9018519;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-6782135;Reactome: R-HSA-76042;Reactome: R-HSA-6781823 "mRNA Splicing - Major Pathway";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Termination";"mRNA Capping";"Viral Messenger RNA Synthesis";"HIV elongation arrest and recovery";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Formation of the Early Elongation Complex";"mRNA Splicing - Minor Pathway";"RNA Polymerase I Transcription Termination";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcriptional regulation by small RNAs";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Promoter Escape";"RNA Polymerase III Chain Elongation";"MicroRNA (miRNA) biogenesis";"RNA Polymerase II Pre-transcription Events";"NoRC negatively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase I Promoter Escape";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"B-WICH complex positively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Processing of Capped Intron-Containing Pre-mRNA";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Transcription Elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Estrogen-dependent gene expression";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"Dual incision in TC-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of TC-NER Pre-Incision Complex" XP_046749680.1 5 Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Neutrophil degranulation";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic" XP_046734271.1 13 Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72706 "SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046746674.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046741020.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046734011.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-3108214 "Protein ubiquitination";"SUMOylation of DNA damage response and repair proteins" XP_046734380.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046744072.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046752894.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046741696.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046748917.1 6 Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-6798695;Reactome: R-HSA-917977;Reactome: R-HSA-983712 "Insulin receptor recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Neutrophil degranulation";"Transferrin endocytosis and recycling";"Ion channel transport" XP_046737624.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046734292.1 2 Reactome: R-HSA-5678895;Reactome: R-HSA-382556 "Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport" XP_046743066.1 4 Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "MHC class II antigen presentation";"RHO GTPases activate KTN1";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046747798.1 1 Reactome: R-HSA-2995383 "Initiation of Nuclear Envelope Reformation" XP_046740488.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046742404.1 8 KEGG: 00030+5.3.1.6;Reactome: R-HSA-5659996;Reactome: R-HSA-6791461;MetaCyc: PWY-1861;KEGG: 00051+5.3.1.6;KEGG: 00710+5.3.1.6;MetaCyc: PWY-5723;Reactome: R-HSA-71336 "Pentose phosphate pathway";"RPIA deficiency: failed conversion of R5P to RU5P";"RPIA deficiency: failed conversion of RU5P to R5P";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Fructose and mannose metabolism";"Carbon fixation in photosynthetic organisms";"Rubisco shunt";"Pentose phosphate pathway" XP_046746661.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046745977.1 2 Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28 "Digestion of dietary carbohydrate";"Starch and sucrose metabolism" XP_046745315.1 14 Reactome: R-HSA-8948700;Reactome: R-HSA-8943723;Reactome: R-HSA-9018519;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-203927;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-426486;Reactome: R-HSA-9029569;Reactome: R-HSA-8986944;Reactome: R-HSA-8934593;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408 "Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of PTEN mRNA translation";"Estrogen-dependent gene expression";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"MicroRNA (miRNA) biogenesis";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Small interfering RNA (siRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transcriptional Regulation by MECP2";"Regulation of RUNX1 Expression and Activity";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation" XP_046739203.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046738561.1 2 Reactome: R-HSA-6796648;Reactome: R-HSA-6783310 "TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway" XP_046748953.1 5 KEGG: 00290+4.2.1.33;Reactome: R-HSA-917937;KEGG: 00020+4.2.1.3;KEGG: 00630+4.2.1.3;KEGG: 00720+4.2.1.3 "Valine, leucine and isoleucine biosynthesis";"Iron uptake and transport";"Citrate cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes" XP_046753940.1 1 Reactome: R-HSA-163560 "Triglyceride catabolism" XP_046749206.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046749519.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046739724.1 14 KEGG: 00564+2.3.1.51;MetaCyc: PWY-7589;MetaCyc: PWY-5667;MetaCyc: PWY-7587;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7411;MetaCyc: PWY-7417;MetaCyc: PWY-5981;MetaCyc: PWY-8055;MetaCyc: PWY-8053 "Glycerophospholipid metabolism";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Plasmalogen biosynthesis";"Synthesis of PA";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II" XP_046734913.1 4 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" XP_046734225.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046743659.1 10 Reactome: R-HSA-9613354;Reactome: R-HSA-1632852;Reactome: R-HSA-2151209;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-200425;Reactome: R-HSA-163680;Reactome: R-HSA-6804756 "Lipophagy";"Macroautophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Carnitine metabolism";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation" XP_046745706.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046742547.1 13 MetaCyc: PWY-6969;Reactome: R-HSA-71403;MetaCyc: PWY-5537;MetaCyc: PWY-6728;MetaCyc: PWY-5913;KEGG: 00720+6.2.1.5;KEGG: 00640+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-7384;MetaCyc: PWY-5538;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-5392 "TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citric acid cycle (TCA cycle)";"Pyruvate fermentation to acetate V";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"Carbon fixation pathways in prokaryotes";"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Pyruvate fermentation to acetate VI";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Reductive TCA cycle II" XP_046743897.1 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" XP_046752089.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046740145.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046741411.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046734683.1 3 Reactome: R-HSA-983189;Reactome: R-HSA-390471;Reactome: R-HSA-6811434 "Kinesins";"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046745171.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046751300.1 7 Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942 "AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition" XP_046742884.1 3 Reactome: R-HSA-192456;MetaCyc: PWY-6857;KEGG: 00561+3.1.1.3 "Digestion of dietary lipid";"Retinol biosynthesis";"Glycerolipid metabolism" XP_046737348.1 16 MetaCyc: PWY-7124;KEGG: 00010+4.2.1.11;MetaCyc: PWY-5484;KEGG: 00680+4.2.1.11;MetaCyc: PWY-8004;MetaCyc: PWY-5723;Reactome: R-HSA-70263;MetaCyc: PWY-7003;MetaCyc: PWY-6886;MetaCyc: PWY-2221;MetaCyc: PWY-6142;MetaCyc: PWY-6901;MetaCyc: PWY-1042;MetaCyc: PWY-1622;MetaCyc: PWY-7218;Reactome: R-HSA-70171 "Ethylene biosynthesis V (engineered)";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism";"Entner-Doudoroff pathway I";"Rubisco shunt";"Gluconeogenesis";"Glycerol degradation to butanol";"1-butanol autotrophic biosynthesis (engineered)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Superpathway of glucose and xylose degradation";"Glycolysis IV (plant cytosol)";"Formaldehyde assimilation I (serine pathway)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis" XP_046751779.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046746180.1 18 MetaCyc: PWY-6642;KEGG: 00330+2.6.1.1;MetaCyc: PWY-7383;MetaCyc: PWY-7117;KEGG: 00350+2.6.1.1;KEGG: 00950+2.6.1.1;MetaCyc: PWY-5913;MetaCyc: PWY-7115;KEGG: 00960+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00401+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00270+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00400+2.6.1.1;MetaCyc: PWY-6638 "(R)-cysteate degradation";"Arginine and proline metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Tyrosine metabolism";"Isoquinoline alkaloid biosynthesis";"Partial TCA cycle (obligate autotrophs)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Coenzyme M biosynthesis II";"Novobiocin biosynthesis";"Carbon fixation in photosynthetic organisms";"Phenylalanine metabolism";"Alanine, aspartate and glutamate metabolism";"Cysteine and methionine metabolism";"Arginine biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Sulfolactate degradation III" XP_046735813.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046749395.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription" XP_046748192.1 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" XP_046748721.1 7 Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380259 "Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes" XP_046737424.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046748591.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046748479.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046743595.1 2 Reactome: R-HSA-9603798;Reactome: R-HSA-1369062 "Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis" XP_046735994.1 2 Reactome: R-HSA-1483115;Reactome: R-HSA-1483152 "Hydrolysis of LPC";"Hydrolysis of LPE" XP_046742289.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046751368.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046750127.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046744976.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046751007.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-8964038 "Neutrophil degranulation";"LDL clearance" XP_046743688.1 19 Reactome: R-HSA-5627123;Reactome: R-HSA-428543;Reactome: R-HSA-5626467;Reactome: R-HSA-389359;Reactome: R-HSA-8964616;Reactome: R-HSA-182971;Reactome: R-HSA-194840;Reactome: R-HSA-5663213;Reactome: R-HSA-5625970;Reactome: R-HSA-5687128;Reactome: R-HSA-114604;Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-525793;Reactome: R-HSA-8950505;Reactome: R-HSA-4420097;Reactome: R-HSA-983231;Reactome: R-HSA-5663220;Reactome: R-HSA-418885 "RHO GTPases activate PAKs";"Inactivation of CDC42 and RAC1";"RHO GTPases activate IQGAPs";"CD28 dependent Vav1 pathway";"G beta:gamma signalling through CDC42";"EGFR downregulation";"Rho GTPase cycle";"RHO GTPases Activate WASPs and WAVEs";"RHO GTPases activate KTN1";"MAPK6/MAPK4 signaling";"GPVI-mediated activation cascade";"Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"Myogenesis";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"VEGFA-VEGFR2 Pathway";"Factors involved in megakaryocyte development and platelet production";"RHO GTPases Activate Formins";"DCC mediated attractive signaling" XP_046752513.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046752627.1 12 KEGG: 00920+2.7.7.4;KEGG: 00920+2.7.1.25;KEGG: 00261+2.7.7.4;Reactome: R-HSA-2408550;KEGG: 00450+2.7.7.4;MetaCyc: PWY-6932;MetaCyc: PWY-5340;KEGG: 00230+2.7.1.25;KEGG: 00230+2.7.7.4;MetaCyc: PWY-5278;Reactome: R-HSA-174362;MetaCyc: PWY-6683 "Sulfur metabolism";"Sulfur metabolism";"Monobactam biosynthesis";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Selenocompound metabolism";"Selenate reduction";"Sulfate activation for sulfonation";"Purine metabolism";"Purine metabolism";"Sulfite oxidation III";"Transport and synthesis of PAPS";"Assimilatory sulfate reduction III" XP_046736854.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046744832.1 3 Reactome: R-HSA-1660517;Reactome: R-HSA-1660516;Reactome: R-HSA-1660514 "Synthesis of PIPs at the late endosome membrane";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the Golgi membrane" XP_046735537.1 3 Reactome: R-HSA-73843;KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1 "5-Phosphoribose 1-diphosphate biosynthesis";"Pentose phosphate pathway";"Purine metabolism" XP_046742507.1 15 MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-6142;MetaCyc: PWY-6901;MetaCyc: PWY-2221;KEGG: 00010+2.7.1.40;MetaCyc: PWY-6886;Reactome: R-HSA-70171;MetaCyc: PWY-7003;MetaCyc: PWY-7383;MetaCyc: PWY-7218;MetaCyc: PWY-5723;MetaCyc: PWY-8004;KEGG: 00230+2.7.1.40;KEGG: 00620+2.7.1.40 "Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Superpathway of glucose and xylose degradation";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Glycolysis / Gluconeogenesis";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis";"Glycerol degradation to butanol";"Anaerobic energy metabolism (invertebrates, cytosol)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Rubisco shunt";"Entner-Doudoroff pathway I";"Purine metabolism";"Pyruvate metabolism" XP_046750302.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046750956.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046746172.1 57 Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5658442;Reactome: R-HSA-6798695;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-5607761;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-1236974;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684 "FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of RAS by GAPs";"Neutrophil degranulation";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"ER-Phagosome pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state" XP_046752949.1 1 Reactome: R-HSA-6811438 "Intra-Golgi traffic" XP_046747351.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046741913.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway" XP_046747463.1 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" XP_046738676.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046747022.1 11 Reactome: R-HSA-2559580;Reactome: R-HSA-450302;KEGG: 04926+2.7.11.1;Reactome: R-HSA-171007;KEGG: 05165+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Oxidative Stress Induced Senescence";"activated TAK1 mediates p38 MAPK activation";"Relaxin signaling pathway";"p38MAPK events";"Human papillomavirus infection";"VEGFA-VEGFR2 Pathway";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" XP_046753480.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046741142.1 6 KEGG: 00500+2.4.1.18;MetaCyc: PWY-7900;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085;MetaCyc: PWY-622;MetaCyc: PWY-5067 "Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate";"Starch biosynthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)" XP_046753016.1 13 Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;Reactome: R-HSA-2022857;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916 "CS/DS degradation";"Glycosphingolipid metabolism";"Keratan sulfate degradation";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Chitin degradation III (Serratia)";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation" XP_046743344.1 5 MetaCyc: PWY-5084;Reactome: R-HSA-389661;KEGG: 00020+1.2.4.2;KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2 "2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)";"Tryptophan metabolism";"Lysine degradation" XP_046751458.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046737628.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046754009.1 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" XP_046749034.1 2 Reactome: R-HSA-381038;Reactome: R-HSA-1799339 "XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane" XP_046746990.1 58 Reactome: R-HSA-1236974;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-180585;Reactome: R-HSA-69601;Reactome: R-HSA-202424;Reactome: R-HSA-4641258;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-6798695;Reactome: R-HSA-174113;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-5689901;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751 "ER-Phagosome pathway";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Vif-mediated degradation of APOBEC3G";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Downstream TCR signaling";"Degradation of DVL";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Neutrophil degranulation";"SCF-beta-TrCP mediated degradation of Emi1";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Metalloprotease DUBs";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity" XP_046740874.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046744073.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046733749.1 4 Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394 "Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER" XP_046736446.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046743718.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046742747.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046735761.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046743163.1 1 KEGG: 00051+4.2.1.68 "Fructose and mannose metabolism" XP_046750543.1 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046744831.1 5 Reactome: R-HSA-936440;Reactome: R-HSA-9013973;Reactome: R-HSA-936964;Reactome: R-HSA-933541;Reactome: R-HSA-918233 "Negative regulators of DDX58/IFIH1 signaling";"TICAM1-dependent activation of IRF3/IRF7";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF6 mediated IRF7 activation";"TRAF3-dependent IRF activation pathway" XP_046736620.1 15 MetaCyc: PWY-7383;MetaCyc: PWY-7003;Reactome: R-HSA-70171;MetaCyc: PWY-7218;MetaCyc: PWY-8004;MetaCyc: PWY-5723;KEGG: 00230+2.7.1.40;KEGG: 00620+2.7.1.40;MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-6901;MetaCyc: PWY-6142;MetaCyc: PWY-2221;KEGG: 00010+2.7.1.40;MetaCyc: PWY-6886 "Anaerobic energy metabolism (invertebrates, cytosol)";"Glycerol degradation to butanol";"Glycolysis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Entner-Doudoroff pathway I";"Rubisco shunt";"Purine metabolism";"Pyruvate metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Glycolysis / Gluconeogenesis";"1-butanol autotrophic biosynthesis (engineered)" XP_046737788.1 12 KEGG: 00710+4.1.2.13;KEGG: 00010+4.1.2.13;KEGG: 00030+4.1.2.13;KEGG: 00680+4.1.2.13;Reactome: R-HSA-70171;Reactome: R-HSA-70263;KEGG: 00051+4.1.2.13;MetaCyc: PWY-1861;MetaCyc: PWY-6142;MetaCyc: PWY-1042;MetaCyc: PWY-7385;MetaCyc: PWY-5484 "Carbon fixation in photosynthetic organisms";"Glycolysis / Gluconeogenesis";"Pentose phosphate pathway";"Methane metabolism";"Glycolysis";"Gluconeogenesis";"Fructose and mannose metabolism";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)" XP_046748071.1 4 MetaCyc: PWY-7382;KEGG: 00785+2.8.1.8;MetaCyc: PWY-6987;Reactome: R-HSA-389661 "Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation III (Bacillus)";"Glyoxylate metabolism and glycine degradation" XP_046753487.1 7 Reactome: R-HSA-2500257;Reactome: R-HSA-606279;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025 "Resolution of Sister Chromatid Cohesion";"Deposition of new CENPA-containing nucleosomes at the centromere";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation" XP_046751605.1 4 Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-674695;Reactome: R-HSA-75955 "Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation" XP_046735685.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046739042.1 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" XP_046740871.1 2 KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716 "Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation" XP_046748435.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046740270.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046737659.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046741391.1 3 Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213 "VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs" XP_046747287.1 8 Reactome: R-HSA-74217;MetaCyc: PWY-6611;MetaCyc: PWY-7179;Reactome: R-HSA-5683826;MetaCyc: PWY-6609;KEGG: 00230+3.5.4.4;MetaCyc: PWY-7179-1;Reactome: R-HSA-6798695 "Purine salvage";"Adenine and adenosine salvage V";"Purine deoxyribonucleosides degradation I";"Surfactant metabolism";"Adenine and adenosine salvage III";"Purine metabolism";"Purine deoxyribonucleosides degradation II";"Neutrophil degranulation" XP_046740159.1 2 Reactome: R-HSA-8866907;Reactome: R-HSA-8866904 "Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors" XP_046743833.1 4 Reactome: R-HSA-351202;KEGG: 00330+2.5.1.16;KEGG: 00270+2.5.1.16;KEGG: 00480+2.5.1.16 "Metabolism of polyamines";"Arginine and proline metabolism";"Cysteine and methionine metabolism";"Glutathione metabolism" XP_046739173.1 1 Reactome: R-HSA-8849932 "Synaptic adhesion-like molecules" XP_046739464.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" XP_046740786.1 2 KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1 "Pentose phosphate pathway";"Purine metabolism" XP_046738325.1 17 MetaCyc: PWY-5392;KEGG: 00020+1.1.1.37;MetaCyc: PWY-5913;KEGG: 00620+1.1.1.37;MetaCyc: PWY-7115;MetaCyc: PWY-7383;KEGG: 00710+1.1.1.37;MetaCyc: PWY-6728;MetaCyc: PWY-1622;MetaCyc: PWY-5690;MetaCyc: PWY-561;MetaCyc: PWY-8086;KEGG: 00680+1.1.1.37;KEGG: 00270+1.1.1.37;KEGG: 00630+1.1.1.37;KEGG: 00720+1.1.1.37;MetaCyc: PWY-6969 "Reductive TCA cycle II";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Pyruvate metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Carbon fixation in photosynthetic organisms";"Methylaspartate cycle";"Formaldehyde assimilation I (serine pathway)";"TCA cycle II (plants and fungi)";"Superpathway of glyoxylate cycle and fatty acid degradation";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Methane metabolism";"Cysteine and methionine metabolism";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)" XP_046742548.1 13 Reactome: R-HSA-71403;MetaCyc: PWY-6969;MetaCyc: PWY-6728;MetaCyc: PWY-5537;MetaCyc: PWY-7384;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5913;KEGG: 00640+6.2.1.5;KEGG: 00720+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538;MetaCyc: PWY-5392;MetaCyc: PWY-5690 "Citric acid cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle";"Pyruvate fermentation to acetate V";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"C5-Branched dibasic acid metabolism";"Partial TCA cycle (obligate autotrophs)";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)" XP_046734462.1 5 MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6317 "Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)" XP_046736197.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046750418.1 1 Reactome: R-HSA-197264 "Nicotinamide salvaging" XP_046743063.1 2 Reactome: R-HSA-9033241;Reactome: R-HSA-389661 "Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation" XP_046735467.1 2 Reactome: R-HSA-71403;Reactome: R-HSA-611105 "Citric acid cycle (TCA cycle)";"Respiratory electron transport" XP_046736692.1 4 Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" XP_046742416.1 4 Reactome: R-HSA-983168;Reactome: R-HSA-1632852;Reactome: R-HSA-6802952;Reactome: R-HSA-6798695 "Antigen processing: Ubiquitination & Proteasome degradation";"Macroautophagy";"Signaling by BRAF and RAF fusions";"Neutrophil degranulation" XP_046750305.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046733937.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046750087.1 5 Reactome: R-HSA-6804758;Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-427389 "Regulation of TP53 Activity through Acetylation";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" XP_046746806.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046742055.1 3 KEGG: 00790+2.8.1.9;MetaCyc: PWY-5963;Reactome: R-HSA-947581 "Folate biosynthesis";"Thio-molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis" XP_046741033.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046753432.1 5 MetaCyc: PWY-5083;MetaCyc: PWY-7269;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807 "NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism" XP_046748174.1 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" XP_046744080.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046740245.1 5 Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-75035;Reactome: R-HSA-5625740;Reactome: R-HSA-5628897 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes" XP_046735373.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046747253.1 1 Reactome: R-HSA-5689603 "UCH proteinases" XP_046739520.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046751757.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046736539.1 2 Reactome: R-HSA-1268020;Reactome: R-HSA-611105 "Mitochondrial protein import";"Respiratory electron transport" XP_046747315.1 3 Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148 "Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046742426.1 5 MetaCyc: PWY-6344;MetaCyc: PWY-4981;KEGG: 00330+1.5.1.2;Reactome: R-HSA-8964539;MetaCyc: PWY-3341 "L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)";"Arginine and proline metabolism";"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)" XP_046748879.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046734731.1 1 Reactome: R-HSA-8866654 "E3 ubiquitin ligases ubiquitinate target proteins" XP_046739715.1 31 MetaCyc: PWYG-321;MetaCyc: PWY-5989;MetaCyc: PWY-6282;MetaCyc: PWY-8047;MetaCyc: PWY-6519;MetaCyc: PWY-5142;MetaCyc: PWY-5973;MetaCyc: PWY-6799;MetaCyc: PWY-4381;MetaCyc: PWY-5367;MetaCyc: PWY-7388;MetaCyc: PWY-5966-1;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5971;MetaCyc: PWY-7664;MetaCyc: PWY-6113;MetaCyc: PWY-7663;Reactome: R-HSA-75105;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-2426168;MetaCyc: PWY-5147;MetaCyc: PWY-7858;MetaCyc: PWY-8012;Reactome: R-HSA-9029558;Reactome: R-HSA-199220;MetaCyc: PWY-8049;Reactome: R-HSA-163765;MetaCyc: PWY-5994;MetaCyc: PWY-7723;MetaCyc: PWY-7746;MetaCyc: PWY-5366 "";"Stearate biosynthesis II (bacteria and plants)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Bryostatin biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Acyl-[acyl-carrier protein] thioesterase pathway";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Petroselinate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis IV (anaerobic)";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"Fatty acyl-CoA biosynthesis";"Biotin metabolism";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis I (plants)";"(5Z)-dodecenoate biosynthesis II";"Mupirocin biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Vitamin B5 (pantothenate) metabolism";"Pederin biosynthesis";"ChREBP activates metabolic gene expression";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Bacterial bioluminescence";"Mycobacterial sulfolipid biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)" XP_046748993.1 4 Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046749673.1 1 Reactome: R-HSA-159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046743640.1 3 MetaCyc: PWY-6369;Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21 "Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system" XP_046742066.1 2 Reactome: R-HSA-203927;Reactome: R-HSA-426486 "MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis" XP_046753633.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" XP_046736792.1 15 Reactome: R-HSA-5358752;Reactome: R-HSA-5467348;Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-5339716;Reactome: R-HSA-5689896;Reactome: R-HSA-5467333;Reactome: R-HSA-3769402;Reactome: R-HSA-195253;Reactome: R-HSA-111465;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-5467340 "T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"Misspliced GSK3beta mutants stabilize beta-catenin";"Ovarian tumor domain proteases";"APC truncation mutants are not K63 polyubiquitinated";"Deactivation of the beta-catenin transactivating complex";"Degradation of beta-catenin by the destruction complex";"Apoptotic cleavage of cellular proteins";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"AXIN missense mutants destabilize the destruction complex" XP_046750792.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046733740.1 11 Reactome: R-HSA-8940973;Reactome: R-HSA-983231;Reactome: R-HSA-5663213;Reactome: R-HSA-8939236;Reactome: R-HSA-5685938;Reactome: R-HSA-428890;KEGG: 04660+2.7.10.2;Reactome: R-HSA-69231;Reactome: R-HSA-2029482;Reactome: R-HSA-5693565;Reactome: R-HSA-525793 "RUNX2 regulates osteoblast differentiation";"Factors involved in megakaryocyte development and platelet production";"RHO GTPases Activate WASPs and WAVEs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"HDR through Single Strand Annealing (SSA)";"Role of ABL in ROBO-SLIT signaling";"T cell receptor signaling pathway";"Cyclin D associated events in G1";"Regulation of actin dynamics for phagocytic cup formation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Myogenesis" XP_046744916.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" XP_046750729.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046735259.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046735568.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046749982.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046735707.1 5 Reactome: R-HSA-77595;Reactome: R-HSA-72163;Reactome: R-HSA-159231;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA Derived from an Intronless Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" XP_046744156.1 1 KEGG: 04660+2.7.10.2 "T cell receptor signaling pathway" XP_046748284.1 30 Reactome: R-HSA-2871837;Reactome: R-HSA-9604323;Reactome: R-HSA-1169091;Reactome: R-HSA-69231;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-2122947;Reactome: R-HSA-2565942;Reactome: R-HSA-187577;Reactome: R-HSA-8939902;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-400253;Reactome: R-HSA-5610783;Reactome: R-HSA-5610780;Reactome: R-HSA-5607764;Reactome: R-HSA-9020702;Reactome: R-HSA-195253;Reactome: R-HSA-917937;Reactome: R-HSA-180534;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-5684264;Reactome: R-HSA-2894862;Reactome: R-HSA-1170546;Reactome: R-HSA-2644607;Reactome: R-HSA-2644606;Reactome: R-HSA-68949;Reactome: R-HSA-8951664 "FCERI mediated NF-kB activation";"Negative regulation of NOTCH4 signaling";"Activation of NF-kappaB in B cells";"Cyclin D associated events in G1";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of PLK1 Activity at G2/M Transition";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of RUNX2 expression and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Circadian Clock";"Degradation of GLI2 by the proteasome";"Degradation of GLI1 by the proteasome";"CLEC7A (Dectin-1) signaling";"Interleukin-1 signaling";"Degradation of beta-catenin by the destruction complex";"Iron uptake and transport";"Vpu mediated degradation of CD4";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Prolactin receptor signaling";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Orc1 removal from chromatin";"Neddylation" XP_046740409.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046736156.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046753798.1 17 Reactome: R-HSA-937042;Reactome: R-HSA-450302;Reactome: R-HSA-168638;Reactome: R-HSA-4086398;Reactome: R-HSA-450321;Reactome: R-HSA-975163;Reactome: R-HSA-9014325;Reactome: R-HSA-445989;Reactome: R-HSA-9645460;Reactome: R-HSA-5357956;Reactome: R-HSA-937072;Reactome: R-HSA-5689880;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-5607764;Reactome: R-HSA-9020702 "IRAK2 mediated activation of TAK1 complex";"activated TAK1 mediates p38 MAPK activation";"NOD1/2 Signaling Pathway";"Ca2+ pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Alpha-protein kinase 1 signaling pathway";"TNFR1-induced NFkappaB signaling pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Ub-specific processing proteases";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"CLEC7A (Dectin-1) signaling";"Interleukin-1 signaling" XP_046740201.1 12 MetaCyc: PWY-6309;KEGG: 00380+2.6.1.7;KEGG: 00270+4.4.1.13;KEGG: 00450+4.4.1.13;MetaCyc: PWY-6842;Reactome: R-HSA-71240;MetaCyc: PWY-601;MetaCyc: PWY-7901;MetaCyc: PWY-1187;MetaCyc: PWY-6936;MetaCyc: PWY-801;MetaCyc: PWY-2821 "L-tryptophan degradation XI (mammalian, via kynurenine)";"Tryptophan metabolism";"Cysteine and methionine metabolism";"Selenocompound metabolism";"Glutathione-mediated detoxification II";"Tryptophan catabolism";"Glucosinolate biosynthesis from tryptophan";"Glucosinolate biosynthesis from tyrosine";"Glucosinolate biosynthesis from homomethionine";"Seleno-amino acid biosynthesis (plants)";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from phenylalanine" XP_046752567.1 2 MetaCyc: PWY-7799;MetaCyc: PWY-7802 "Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)" XP_046735304.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046737474.1 7 Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380259 "Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes" XP_046737026.1 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" XP_046751720.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" XP_046736114.1 5 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-77595 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs" XP_046751141.1 4 KEGG: 00564+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32 "Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism" XP_046737461.1 4 Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-983712 "ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Ion channel transport" XP_046749643.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046742198.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046734836.1 3 Reactome: R-HSA-1237112;KEGG: 00270+1.13.11.54;MetaCyc: PWY-4361 "Methionine salvage pathway";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I" XP_046746842.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046743755.1 4 Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination" XP_046750615.1 6 Reactome: R-HSA-8951430;Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-4411364;Reactome: R-HSA-4086398 "RUNX3 regulates WNT signaling";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Ca2+ pathway" XP_046739918.1 5 Reactome: R-HSA-3247509;Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-1266695;Reactome: R-HSA-3214858 "Chromatin modifying enzymes";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"Interleukin-7 signaling";"RMTs methylate histone arginines" XP_046742160.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046747107.1 1 Reactome: R-HSA-399956 "CRMPs in Sema3A signaling" XP_046749974.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046743516.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046751440.1 1 Reactome: R-HSA-211981 "Xenobiotics" XP_046752176.1 2 Reactome: R-HSA-1268020;Reactome: R-HSA-611105 "Mitochondrial protein import";"Respiratory electron transport" XP_046736269.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046753747.1 2 MetaCyc: PWY-5697;KEGG: 00230+3.5.3.4 "Allantoin degradation to ureidoglycolate I (urea producing)";"Purine metabolism" XP_046743698.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046745877.1 3 Reactome: R-HSA-1799339;Reactome: R-HSA-9609523;Reactome: R-HSA-1236974 "SRP-dependent cotranslational protein targeting to membrane";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"ER-Phagosome pathway" XP_046734679.1 1 Reactome: R-HSA-203927 "MicroRNA (miRNA) biogenesis" XP_046741116.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046746236.1 6 MetaCyc: PWY-622;MetaCyc: PWY-5067;MetaCyc: PWY-7900;KEGG: 00500+2.4.1.18;Reactome: R-HSA-3322077;Reactome: R-HSA-3878781 "Starch biosynthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Glycogen synthesis";"Glycogen storage disease type IV (GBE1)" XP_046736018.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046740774.1 2 Reactome: R-HSA-8949613;Reactome: R-HSA-163210 "Cristae formation";"Formation of ATP by chemiosmotic coupling" XP_046751628.1 4 Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-6781823;Reactome: R-HSA-5696395 "Dual incision in TC-NER";"Dual Incision in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Formation of Incision Complex in GG-NER" XP_046744733.1 2 Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" XP_046748045.1 19 Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-6790901;Reactome: R-HSA-72649;Reactome: R-HSA-8876725;Reactome: R-HSA-3214858;Reactome: R-HSA-72764;Reactome: R-HSA-72689 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"rRNA modification in the nucleus and cytosol";"Translation initiation complex formation";"Protein methylation";"RMTs methylate histone arginines";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits" XP_046746747.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046738831.1 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" XP_046748474.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046743345.1 5 MetaCyc: PWY-5084;Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2 "2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"Tryptophan metabolism";"Citrate cycle (TCA cycle)" XP_046747821.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046748017.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046736238.1 2 Reactome: R-HSA-5689880;Reactome: R-HSA-1632852 "Ub-specific processing proteases";"Macroautophagy" XP_046751679.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" XP_046735886.1 1 Reactome: R-HSA-425986 "Sodium/Proton exchangers" XP_046746909.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046743757.1 1 Reactome: R-HSA-4551638 "SUMOylation of chromatin organization proteins" XP_046745850.1 4 KEGG: 00970+6.1.1.17;Reactome: R-HSA-379726;KEGG: 00860+6.1.1.17;MetaCyc: PWY-5188 "Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)" XP_046751063.1 3 Reactome: R-HSA-164843;Reactome: R-HSA-5693571;Reactome: R-HSA-3108214 "2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)";"SUMOylation of DNA damage response and repair proteins" XP_046736690.1 4 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" XP_046741432.1 5 Reactome: R-HSA-5675221;Reactome: R-HSA-112409;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "Negative regulation of MAPK pathway";"RAF-independent MAPK1/3 activation";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046751286.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046739735.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046734797.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046750637.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046736021.1 5 Reactome: R-HSA-8856825;Reactome: R-HSA-432722;Reactome: R-HSA-6798695;Reactome: R-HSA-8856828;Reactome: R-HSA-6811440 "Cargo recognition for clathrin-mediated endocytosis";"Golgi Associated Vesicle Biogenesis";"Neutrophil degranulation";"Clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network" XP_046746954.1 7 KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046750079.1 57 Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-1236974;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-75815;Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-983168;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-450408;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-6798695;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-5658442;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837 "Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"ER-Phagosome pathway";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Neutrophil degranulation";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Regulation of RAS by GAPs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation" XP_046750177.1 4 Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553 "Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" XP_046733877.1 6 KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499;MetaCyc: PWY-6368;Reactome: R-HSA-1660516;KEGG: 00562+3.1.3.66;Reactome: R-HSA-1855183 "Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"3-phosphoinositide degradation";"Synthesis of PIPs at the early endosome membrane";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol" XP_046740279.1 5 Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)" XP_046736744.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046736885.1 3 Reactome: R-HSA-390471;Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Association of TriC/CCT with target proteins during biosynthesis";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046737869.1 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" XP_046743691.1 19 Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-525793;Reactome: R-HSA-8950505;Reactome: R-HSA-4420097;Reactome: R-HSA-983231;Reactome: R-HSA-5663220;Reactome: R-HSA-418885;Reactome: R-HSA-5627123;Reactome: R-HSA-428543;Reactome: R-HSA-5626467;Reactome: R-HSA-389359;Reactome: R-HSA-8964616;Reactome: R-HSA-182971;Reactome: R-HSA-194840;Reactome: R-HSA-5663213;Reactome: R-HSA-5687128;Reactome: R-HSA-5625970;Reactome: R-HSA-114604 "Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"Myogenesis";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"VEGFA-VEGFR2 Pathway";"Factors involved in megakaryocyte development and platelet production";"RHO GTPases Activate Formins";"DCC mediated attractive signaling";"RHO GTPases activate PAKs";"Inactivation of CDC42 and RAC1";"RHO GTPases activate IQGAPs";"CD28 dependent Vav1 pathway";"G beta:gamma signalling through CDC42";"EGFR downregulation";"Rho GTPase cycle";"RHO GTPases Activate WASPs and WAVEs";"MAPK6/MAPK4 signaling";"RHO GTPases activate KTN1";"GPVI-mediated activation cascade" XP_046753278.1 2 Reactome: R-HSA-8949664;Reactome: R-HSA-8949215 "Processing of SMDT1";"Mitochondrial calcium ion transport" XP_046744167.1 3 Reactome: R-HSA-264876;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916 "Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium" XP_046753678.1 7 Reactome: R-HSA-6783310;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-176187;Reactome: R-HSA-5685938 "Fanconi Anemia Pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress";"HDR through Single Strand Annealing (SSA)" XP_046746049.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046736272.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046748353.1 13 Reactome: R-HSA-177504;Reactome: R-HSA-8866427;Reactome: R-HSA-8856825;Reactome: R-HSA-8964038;Reactome: R-HSA-167590;Reactome: R-HSA-5140745;Reactome: R-HSA-416993;Reactome: R-HSA-437239;Reactome: R-HSA-182218;Reactome: R-HSA-8856828;Reactome: R-HSA-3928665;Reactome: R-HSA-5099900;Reactome: R-HSA-2132295 "Retrograde neurotrophin signalling";"VLDLR internalisation and degradation";"Cargo recognition for clathrin-mediated endocytosis";"LDL clearance";"Nef Mediated CD4 Down-regulation";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Trafficking of GluR2-containing AMPA receptors";"Recycling pathway of L1";"Nef Mediated CD8 Down-regulation";"Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"WNT5A-dependent internalization of FZD4";"MHC class II antigen presentation" XP_046743837.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046735474.1 1 Reactome: R-HSA-209968 "Thyroxine biosynthesis" XP_046750804.1 57 Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-5658442;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8951664;Reactome: R-HSA-450408;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-180585;Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5362768;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-75815;Reactome: R-HSA-1236974;Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858 "Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Regulation of RAS by GAPs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Vif-mediated degradation of APOBEC3G";"NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway";"Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity" XP_046734807.1 2 Reactome: R-HSA-74217;KEGG: 00230+1.7.1.7 "Purine salvage";"Purine metabolism" XP_046735141.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046744208.1 10 MetaCyc: PWY-6886;KEGG: 00710+2.7.2.3;MetaCyc: PWY-6901;MetaCyc: PWY-5484;MetaCyc: PWY-1042;KEGG: 00010+2.7.2.3;MetaCyc: PWY-8004;MetaCyc: PWY-7003;Reactome: R-HSA-70171;Reactome: R-HSA-70263 "1-butanol autotrophic biosynthesis (engineered)";"Carbon fixation in photosynthetic organisms";"Superpathway of glucose and xylose degradation";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway I";"Glycerol degradation to butanol";"Glycolysis";"Gluconeogenesis" XP_046746676.1 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" XP_046735121.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046736799.1 10 Reactome: R-HSA-70171;KEGG: 00051+2.7.1.11;KEGG: 00030+2.7.1.11;MetaCyc: PWY-1861;MetaCyc: PWY-1042;MetaCyc: PWY-7385;MetaCyc: PWY-5484;KEGG: 00680+2.7.1.11;KEGG: 00052+2.7.1.11;KEGG: 00010+2.7.1.11 "Glycolysis";"Fructose and mannose metabolism";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism";"Galactose metabolism";"Glycolysis / Gluconeogenesis" XP_046752862.1 1 Reactome: R-HSA-4419969 "Depolymerisation of the Nuclear Lamina" XP_046740560.1 2 KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336 "Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway" XP_046737027.1 1 KEGG: 00760+2.3.1.286 "Nicotinate and nicotinamide metabolism" XP_046748369.1 9 Reactome: R-HSA-5693616;Reactome: R-HSA-5685942;Reactome: R-HSA-69473;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938 "Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)";"G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)" XP_046742256.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046746910.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046740758.1 3 Reactome: R-HSA-6784531;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470 "tRNA processing in the nucleus";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion" XP_046751090.1 1 Reactome: R-HSA-2142789 "Ubiquinol biosynthesis" XP_046745205.1 2 Reactome: R-HSA-2299718;Reactome: R-HSA-2514853 "Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes" XP_046740183.1 3 Reactome: R-HSA-4420097;Reactome: R-HSA-391160;KEGG: 04660+2.7.10.2 "VEGFA-VEGFR2 Pathway";"Signal regulatory protein family interactions";"T cell receptor signaling pathway" XP_046742355.1 2 Reactome: R-HSA-8949613;Reactome: R-HSA-1268020 "Cristae formation";"Mitochondrial protein import" XP_046741756.1 11 Reactome: R-HSA-380972;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6804756;Reactome: R-HSA-163680;KEGG: 04926+2.7.11.1;Reactome: R-HSA-9614657 "Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Regulation of TP53 Activity through Phosphorylation";"AMPK inhibits chREBP transcriptional activation activity";"Relaxin signaling pathway";"FOXO-mediated transcription of cell death genes" XP_046751220.1 6 Reactome: R-HSA-8868766;MetaCyc: PWY-7285;MetaCyc: PWY-6829;Reactome: R-HSA-6785470;Reactome: R-HSA-6787450;MetaCyc: PWY-7286 "rRNA processing in the mitochondrion";"Methylwyosine biosynthesis";"Trna methylation (yeast)";"tRNA processing in the mitochondrion";"tRNA modification in the mitochondrion";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis" XP_046737786.1 2 Reactome: R-HSA-2151201;KEGG: 00760+2.3.1.286 "Transcriptional activation of mitochondrial biogenesis";"Nicotinate and nicotinamide metabolism" XP_046745296.1 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" XP_046736576.1 2 Reactome: R-HSA-8873719;Reactome: R-HSA-6803205 "RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" XP_046743207.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046743356.1 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" XP_046753764.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046738518.1 2 KEGG: 00900+2.5.1.58;Reactome: R-HSA-2514859 "Terpenoid backbone biosynthesis";"Inactivation, recovery and regulation of the phototransduction cascade" XP_046743038.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046748677.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046742440.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046743208.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046737379.1 4 Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823 "Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex" XP_046741579.1 4 Reactome: R-HSA-9615017;Reactome: R-HSA-9614399;Reactome: R-HSA-198693;Reactome: R-HSA-5674400 "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of localization of FOXO transcription factors";"AKT phosphorylates targets in the nucleus";"Constitutive Signaling by AKT1 E17K in Cancer" XP_046742641.1 3 Reactome: R-HSA-5579007;Reactome: R-HSA-5423646;KEGG: 00220+3.5.1.14 "Defective ACY1 causes encephalopathy";"Aflatoxin activation and detoxification";"Arginine biosynthesis" XP_046739915.1 5 Reactome: R-HSA-3247509;Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695 "Chromatin modifying enzymes";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"RMTs methylate histone arginines";"Interleukin-7 signaling" XP_046742225.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046737953.1 6 MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463 "Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis" XP_046742751.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046739346.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046735178.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046744102.1 9 MetaCyc: PWY-5667;KEGG: 00564+1.1.1.8;MetaCyc: PWY-6118;MetaCyc: PWY-7902;MetaCyc: PWY-7385;KEGG: 00564+1.1.1.94;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-5981 "CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Glycerol-3-phosphate shuttle";"Glucosylglycerol biosynthesis";"1,3-propanediol biosynthesis (engineered)";"Glycerophospholipid metabolism";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis III" XP_046753670.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046753330.1 19 Reactome: R-HSA-9649948;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-438066;Reactome: R-HSA-5673000;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-6802952;Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-6802946;Reactome: R-HSA-111932;Reactome: R-HSA-9620244 "Signaling downstream of RAS mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Unblocking of NMDA receptors, glutamate binding and activation";"RAF activation";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Signaling by BRAF and RAF fusions";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Signaling by moderate kinase activity BRAF mutants";"CaMK IV-mediated phosphorylation of CREB";"Long-term potentiation" XP_046750671.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046737558.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046751536.1 1 Reactome: R-HSA-191859 "snRNP Assembly" XP_046743421.1 1 Reactome: R-HSA-425410 "Metal ion SLC transporters" XP_046751244.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046736115.1 5 Reactome: R-HSA-77595;Reactome: R-HSA-72163;Reactome: R-HSA-159231;Reactome: R-HSA-72187;Reactome: R-HSA-73856 "Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination" XP_046743267.1 6 MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-7656;Reactome: R-HSA-9640463 "Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis" XP_046742377.1 2 Reactome: R-HSA-70921;KEGG: 00340+2.1.1.22 "Histidine catabolism";"Histidine metabolism" XP_046733916.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046748951.1 5 KEGG: 00020+4.2.1.3;Reactome: R-HSA-917937;KEGG: 00290+4.2.1.33;KEGG: 00720+4.2.1.3;KEGG: 00630+4.2.1.3 "Citrate cycle (TCA cycle)";"Iron uptake and transport";"Valine, leucine and isoleucine biosynthesis";"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism" XP_046748130.1 1 Reactome: R-HSA-6804760 "Regulation of TP53 Activity through Methylation" XP_046743130.1 18 Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-113418;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-167238;Reactome: R-HSA-72086;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-167242;Reactome: R-HSA-167200 "Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of the Early Elongation Complex";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Capping";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat" XP_046749473.1 6 MetaCyc: PWY-6922;KEGG: 00330+2.6.1.13;Reactome: R-HSA-8964539;MetaCyc: PWY-3341;MetaCyc: PWY-6344;MetaCyc: PWY-4981 "L-Ndelta-acetylornithine biosynthesis";"Arginine and proline metabolism";"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)" XP_046743846.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046737031.1 11 KEGG: 00240+6.3.5.5;MetaCyc: PWY-7400;KEGG: 00240+2.1.3.2;KEGG: 00240+3.5.2.3;KEGG: 00250+2.1.3.2;MetaCyc: PWY-7790;Reactome: R-HSA-500753;MetaCyc: PWY-7791;MetaCyc: PWY-5154;KEGG: 00250+6.3.5.5;MetaCyc: PWY-5686 "Pyrimidine metabolism";"L-arginine biosynthesis IV (archaebacteria)";"Pyrimidine metabolism";"Pyrimidine metabolism";"Alanine, aspartate and glutamate metabolism";"UMP biosynthesis II";"Pyrimidine biosynthesis";"UMP biosynthesis III";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Alanine, aspartate and glutamate metabolism";"UMP biosynthesis I" XP_046745265.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046740618.1 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" XP_046750307.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046736512.1 2 Reactome: R-HSA-5205685;Reactome: R-HSA-983231 "Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production" XP_046746673.1 11 MetaCyc: PWY-5659;MetaCyc: PWY-882;KEGG: 00051+5.3.1.8;MetaCyc: PWY-3881;MetaCyc: PWY-7586;Reactome: R-HSA-446205;MetaCyc: PWY-7456;Reactome: R-HSA-4043916;MetaCyc: PWY-3861;KEGG: 00520+5.3.1.8;MetaCyc: PWY-6992 "GDP-mannose biosynthesis";"L-ascorbate biosynthesis I (L-galactose pathway)";"Fructose and mannose metabolism";"Mannitol biosynthesis";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Synthesis of GDP-mannose";"Beta-(1,4)-mannan degradation";"Defective MPI causes MPI-CDG (CDG-1b)";"Mannitol degradation II";"Amino sugar and nucleotide sugar metabolism";"1,5-anhydrofructose degradation" XP_046745262.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046736117.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046739270.1 1 Reactome: R-HSA-70895 "Branched-chain amino acid catabolism" XP_046749975.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" XP_046747541.1 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" XP_046750837.1 1 Reactome: R-HSA-203615 "eNOS activation" XP_046751809.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-400253 "Transcriptional activation of mitochondrial biogenesis";"Circadian Clock" XP_046746106.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046740305.1 8 Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-68616;Reactome: R-HSA-68867;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68962;Reactome: R-HSA-68689 "Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Activation of the pre-replicative complex";"CDC6 association with the ORC:origin complex" XP_046741730.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046735878.1 2 Reactome: R-HSA-5218920;Reactome: R-HSA-418990 "VEGFR2 mediated vascular permeability";"Adherens junctions interactions" XP_046740565.1 2 KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336 "Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway" XP_046741871.1 3 KEGG: 00500+2.4.1.11;Reactome: R-HSA-3322077;MetaCyc: PWY-5067 "Starch and sucrose metabolism";"Glycogen synthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)" XP_046737382.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046735643.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-430039 "mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease" XP_046745444.1 16 Reactome: R-HSA-512988;Reactome: R-HSA-1433557;Reactome: R-HSA-9009391;Reactome: R-HSA-389357;Reactome: R-HSA-912526;Reactome: R-HSA-416476;Reactome: R-HSA-6811558;Reactome: R-HSA-1266695;Reactome: R-HSA-8853659;Reactome: R-HSA-1660499;Reactome: R-HSA-912631;Reactome: R-HSA-2219530;Reactome: R-HSA-388841;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-1257604 "Interleukin-3, Interleukin-5 and GM-CSF signaling";"Signaling by SCF-KIT";"Extra-nuclear estrogen signaling";"CD28 dependent PI3K/Akt signaling";"Interleukin receptor SHC signaling";"G alpha (q) signalling events";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Interleukin-7 signaling";"RET signaling";"Synthesis of PIPs at the plasma membrane";"Regulation of signaling by CBL";"Constitutive Signaling by Aberrant PI3K in Cancer";"Costimulation by the CD28 family";"Rho GTPase cycle";"GPVI-mediated activation cascade";"PIP3 activates AKT signaling" XP_046744778.1 8 Reactome: R-HSA-165159;Reactome: R-HSA-8943724;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-9639288;Reactome: R-HSA-3371571 "mTOR signalling";"Regulation of PTEN gene transcription";"Macroautophagy";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Amino acids regulate mTORC1";"HSF1-dependent transactivation" XP_046736360.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6784531 "Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus" XP_046741472.1 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" XP_046734681.1 4 MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3 "Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Purine metabolism" XP_046753854.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046753428.1 5 Reactome: R-HSA-196807;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;MetaCyc: PWY-5083 "Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation" XP_046736941.1 6 Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046751842.1 1 Reactome: R-HSA-9633012 "Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046744783.1 7 MetaCyc: PWY-7586;MetaCyc: PWY-882;MetaCyc: PWY-7456;KEGG: 00051+5.4.2.8;KEGG: 00520+5.4.2.8;MetaCyc: PWY-5659;Reactome: R-HSA-446205 "Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-(1,4)-mannan degradation";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"GDP-mannose biosynthesis";"Synthesis of GDP-mannose" XP_046748037.1 2 Reactome: R-HSA-2032785;Reactome: R-HSA-8951671 "YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription" XP_046735773.1 1 Reactome: R-HSA-196108 "Pregnenolone biosynthesis" XP_046753521.1 4 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541;Reactome: R-HSA-499943 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Abacavir metabolism";"Interconversion of nucleotide di- and triphosphates" XP_046753765.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046745532.1 1 MetaCyc: PWY-6829 "Trna methylation (yeast)" XP_046751641.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046743007.1 14 Reactome: R-HSA-110314;Reactome: R-HSA-110312;Reactome: R-HSA-110320;Reactome: R-HSA-5685942;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-69091;Reactome: R-HSA-5656169;Reactome: R-HSA-5656121;Reactome: R-HSA-5655862;Reactome: R-HSA-5696397;Reactome: R-HSA-6782210;Reactome: R-HSA-5651801;Reactome: R-HSA-174411 "Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by REV1";"Translesion Synthesis by POLH";"HDR through Homologous Recombination (HRR)";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Polymerase switching";"Termination of translesion DNA synthesis";"Translesion synthesis by POLI";"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere" XP_046740127.1 3 Reactome: R-HSA-5250924;Reactome: R-HSA-72163;Reactome: R-HSA-72165 "B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" XP_046752311.1 3 KEGG: 00511+3.2.1.45;KEGG: 00600+3.2.1.45;Reactome: R-HSA-1660662 "Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid metabolism" XP_046742915.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046739615.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046738426.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046740257.1 14 MetaCyc: PWY-6367;MetaCyc: PWY-8052;Reactome: R-HSA-500657;Reactome: R-HSA-4086398;Reactome: R-HSA-416476;Reactome: R-HSA-1855204;Reactome: R-HSA-112043;KEGG: 04070+3.1.4.11;KEGG: 00562+3.1.4.11;Reactome: R-HSA-418217;Reactome: R-HSA-399997;Reactome: R-HSA-434316;MetaCyc: PWY-7039;MetaCyc: PWY-6351 "D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"Presynaptic function of Kainate receptors";"Ca2+ pathway";"G alpha (q) signalling events";"Synthesis of IP3 and IP4 in the cytosol";"PLC beta mediated events";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"G beta:gamma signalling through PLC beta";"Acetylcholine regulates insulin secretion";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis" XP_046734270.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046737302.1 13 Reactome: R-HSA-9027277;Reactome: R-HSA-1855204;Reactome: R-HSA-202433;Reactome: R-HSA-2871809;MetaCyc: PWY-6367;MetaCyc: PWY-8052;Reactome: R-HSA-2871796;Reactome: R-HSA-2424491;MetaCyc: PWY-7039;MetaCyc: PWY-6351;Reactome: R-HSA-2029485;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11 "Erythropoietin activates Phospholipase C gamma (PLCG)";"Synthesis of IP3 and IP4 in the cytosol";"Generation of second messenger molecules";"FCERI mediated Ca+2 mobilization";"D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"FCERI mediated MAPK activation";"DAP12 signaling";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Role of phospholipids in phagocytosis";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system" XP_046735580.1 1 Reactome: R-HSA-419771 "Opsins" XP_046734401.1 1 Reactome: R-HSA-2028269 "Signaling by Hippo" XP_046752259.1 3 KEGG: 00561+3.1.1.23;Reactome: R-HSA-426048;MetaCyc: PWY-7420 "Glycerolipid metabolism";"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)" XP_046739268.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046740210.1 13 MetaCyc: PWY-7222;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7210;MetaCyc: PWY-7184;Reactome: R-HSA-499943;MetaCyc: PWY-7220;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7226;KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-6545 "Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III" XP_046747410.1 2 Reactome: R-HSA-3214815;Reactome: R-HSA-427413 "HDACs deacetylate histones";"NoRC negatively regulates rRNA expression" XP_046750919.1 3 MetaCyc: PWY-6596;Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6 "Adenosine nucleotides degradation I";"Purine salvage";"Purine metabolism" XP_046735775.1 5 MetaCyc: PWY-5083;MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;Reactome: R-HSA-196807 "NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism" XP_046738683.1 1 Reactome: R-HSA-532668 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" XP_046736176.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046752911.1 24 Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9619483;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-983189;Reactome: R-HSA-6807878;Reactome: R-HSA-8852276 "Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Cilium Assembly";"HCMV Early Events";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Activation of AMPK downstream of NMDARs";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Kinesins";"COPI-mediated anterograde transport";"The role of GTSE1 in G2/M progression after G2 checkpoint" XP_046742431.1 6 KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463 "Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis" XP_046742939.1 1 Reactome: R-HSA-201681 "TCF dependent signaling in response to WNT" XP_046742483.1 1 KEGG: 00240+3.1.3.89 "Pyrimidine metabolism" XP_046748430.1 3 Reactome: R-HSA-2022854;Reactome: R-HSA-5083627;Reactome: R-HSA-5173105 "Keratan sulfate biosynthesis";"Defective LARGE causes MDDGA6 and MDDGB6";"O-linked glycosylation" XP_046748153.1 4 Reactome: R-HSA-3371497;Reactome: R-HSA-8939211;Reactome: R-HSA-9018519;Reactome: R-HSA-3371568 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"ESR-mediated signaling";"Estrogen-dependent gene expression";"Attenuation phase" XP_046750952.1 4 KEGG: 00520+2.7.1.59;MetaCyc: PWY-6517;MetaCyc: PWY-6906;Reactome: R-HSA-446210 "Amino sugar and nucleotide sugar metabolism";"N-acetylglucosamine degradation II";"Chitin derivatives degradation";"Synthesis of UDP-N-acetyl-glucosamine" XP_046753568.1 2 Reactome: R-HSA-71403;Reactome: R-HSA-611105 "Citric acid cycle (TCA cycle)";"Respiratory electron transport" XP_046750879.1 5 Reactome: R-HSA-72163;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823 "mRNA Splicing - Major Pathway";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex" XP_046740479.1 2 Reactome: R-HSA-71403;Reactome: R-HSA-611105 "Citric acid cycle (TCA cycle)";"Respiratory electron transport" XP_046736986.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046743098.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046749745.1 27 Reactome: R-HSA-5358749;KEGG: 05165+2.7.11.1;Reactome: R-HSA-196299;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5467348;KEGG: 05170+2.7.11.1;Reactome: R-HSA-195253;Reactome: R-HSA-5250924;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5610783;Reactome: R-HSA-198323;Reactome: R-HSA-5467340;Reactome: R-HSA-5358751;Reactome: R-HSA-5610785;Reactome: R-HSA-8939902;Reactome: R-HSA-5358747;Reactome: R-HSA-5467337;Reactome: R-HSA-75815;Reactome: R-HSA-5358752;Reactome: R-HSA-3371453;KEGG: 04151+2.7.11.1;Reactome: R-HSA-4641262;Reactome: R-HSA-5674400;Reactome: R-HSA-399956;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5339716;KEGG: 04714+2.7.11.1 "S37 mutants of beta-catenin aren't phosphorylated";"Human papillomavirus infection";"Beta-catenin phosphorylation cascade";"Relaxin signaling pathway";"Truncations of AMER1 destabilize the destruction complex";"Human immunodeficiency virus 1 infection";"Degradation of beta-catenin by the destruction complex";"B-WICH complex positively regulates rRNA expression";"mTOR signaling pathway";"Degradation of GLI2 by the proteasome";"AKT phosphorylates targets in the cytosol";"AXIN missense mutants destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"GLI3 is processed to GLI3R by the proteasome";"Regulation of RUNX2 expression and activity";"S33 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants have impaired AXIN binding";"Ubiquitin-dependent degradation of Cyclin D";"T41 mutants of beta-catenin aren't phosphorylated";"Regulation of HSF1-mediated heat shock response";"PI3K-Akt signaling pathway";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Constitutive Signaling by AKT1 E17K in Cancer";"CRMPs in Sema3A signaling";"Human cytomegalovirus infection";"Misspliced GSK3beta mutants stabilize beta-catenin";"Thermogenesis" XP_046736551.1 1 Reactome: R-HSA-379726 "Mitochondrial tRNA aminoacylation" XP_046740453.1 2 Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13 "Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system" XP_046744233.1 12 Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813 "COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids" XP_046740392.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046736801.1 10 KEGG: 00680+2.7.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-7385;MetaCyc: PWY-1861;KEGG: 00030+2.7.1.11;KEGG: 00010+2.7.1.11;KEGG: 00052+2.7.1.11;Reactome: R-HSA-70171;KEGG: 00051+2.7.1.11 "Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis";"Galactose metabolism";"Glycolysis";"Fructose and mannose metabolism" XP_046747007.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046752412.1 2 Reactome: R-HSA-4641262;Reactome: R-HSA-196299 "Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Beta-catenin phosphorylation cascade" XP_046735214.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046739756.1 4 Reactome: R-HSA-1170546;Reactome: R-HSA-2586552;Reactome: R-HSA-982772;Reactome: R-HSA-983231 "Prolactin receptor signaling";"Signaling by Leptin";"Growth hormone receptor signaling";"Factors involved in megakaryocyte development and platelet production" XP_046744232.1 12 Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025 "HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation" XP_046734536.1 2 KEGG: 00071+2.3.1.21;MetaCyc: PWY-6111 "Fatty acid degradation";"Mitochondrial L-carnitine shuttle" XP_046751578.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046741361.1 4 MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-6902 "Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)" XP_046748762.1 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" XP_046737138.1 2 KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557 "T cell receptor signaling pathway";"Signaling by SCF-KIT" XP_046749165.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046752997.1 10 Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-5628897;Reactome: R-HSA-111459;Reactome: R-HSA-2151201;Reactome: R-HSA-611105;Reactome: R-HSA-111458;Reactome: R-HSA-9627069;Reactome: R-HSA-3299685;Reactome: R-HSA-111457 "SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"TP53 Regulates Metabolic Genes";"Activation of caspases through apoptosome-mediated cleavage";"Transcriptional activation of mitochondrial biogenesis";"Respiratory electron transport";"Formation of apoptosome";"Regulation of the apoptosome activity";"Detoxification of Reactive Oxygen Species";"Release of apoptotic factors from the mitochondria" XP_046752546.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046747515.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046746892.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046749704.1 1 Reactome: R-HSA-373753 "Nephrin family interactions" XP_046741525.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-380095 "G alpha (q) signalling events";"Tachykinin receptors bind tachykinins" XP_046738181.1 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" XP_046743862.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046752057.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046740739.1 8 MetaCyc: PWY-7921;MetaCyc: PWY-7922;Reactome: R-HSA-5173105;Reactome: R-HSA-5083633;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;Reactome: R-HSA-5083629 "Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2" XP_046746590.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046751345.1 5 MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6317 "Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)" XP_046750169.1 16 Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-2559586;Reactome: R-HSA-201722;Reactome: R-HSA-5685938;Reactome: R-HSA-9018519;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693548;Reactome: R-HSA-5693565;Reactome: R-HSA-5685942;Reactome: R-HSA-5693571;Reactome: R-HSA-3214847;Reactome: R-HSA-5693616 "Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"DNA Damage/Telomere Stress Induced Senescence";"Formation of the beta-catenin:TCF transactivating complex";"HDR through Single Strand Annealing (SSA)";"Estrogen-dependent gene expression";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Sensing of DNA Double Strand Breaks";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDR through Homologous Recombination (HRR)";"Nonhomologous End-Joining (NHEJ)";"HATs acetylate histones";"Presynaptic phase of homologous DNA pairing and strand exchange" XP_046751883.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046745230.1 2 Reactome: R-HSA-1482798;Reactome: R-HSA-1268020 "Acyl chain remodeling of CL";"Mitochondrial protein import" XP_046734000.1 9 Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-674695 "RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Pre-transcription Events" XP_046738529.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" XP_046743863.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046750182.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046750843.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046737634.1 9 Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-191859;Reactome: R-HSA-400206 "BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"snRNP Assembly";"Regulation of lipid metabolism by PPARalpha" XP_046737002.1 17 Reactome: R-HSA-2559585;Reactome: R-HSA-9616222;Reactome: R-HSA-69202;Reactome: R-HSA-1912408;Reactome: R-HSA-8953750;Reactome: R-HSA-69656;Reactome: R-HSA-69231;Reactome: R-HSA-2559580;Reactome: R-HSA-113501;Reactome: R-HSA-1538133;Reactome: R-HSA-2173796;Reactome: R-HSA-1362300;Reactome: R-HSA-111448;Reactome: R-HSA-6804114;Reactome: R-HSA-1362277;Reactome: R-HSA-139915;Reactome: R-HSA-69205 "Oncogene Induced Senescence";"Transcriptional regulation of granulopoiesis";"Cyclin E associated events during G1/S transition";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by E2F6";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin D associated events in G1";"Oxidative Stress Induced Senescence";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"G0 and Early G1";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Activation of NOXA and translocation to mitochondria";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcription of E2F targets under negative control by DREAM complex";"Activation of PUMA and translocation to mitochondria";"G1/S-Specific Transcription" XP_046753788.1 7 Reactome: R-HSA-2470946;Reactome: R-HSA-9018519;Reactome: R-HSA-1221632;Reactome: R-HSA-2500257;Reactome: R-HSA-3108214;Reactome: R-HSA-2468052;Reactome: R-HSA-2467813 "Cohesin Loading onto Chromatin";"Estrogen-dependent gene expression";"Meiotic synapsis";"Resolution of Sister Chromatid Cohesion";"SUMOylation of DNA damage response and repair proteins";"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids" XP_046745707.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046745937.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046745362.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046743068.1 4 Reactome: R-HSA-5625970;Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "RHO GTPases activate KTN1";"MHC class II antigen presentation";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046739204.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046736359.1 2 Reactome: R-HSA-6784531;Reactome: R-HSA-6791226 "tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046735748.1 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" XP_046736204.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046739502.1 5 KEGG: 00983+2.4.2.3;KEGG: 00240+2.4.2.3;Reactome: R-HSA-73614;Reactome: R-HSA-73621;MetaCyc: PWY-5532 "Drug metabolism - other enzymes";"Pyrimidine metabolism";"Pyrimidine salvage";"Pyrimidine catabolism";"Nucleoside and nucleotide degradation (archaea)" XP_046749567.1 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" XP_046752258.1 3 Reactome: R-HSA-426048;KEGG: 00561+3.1.1.23;MetaCyc: PWY-7420 "Arachidonate production from DAG";"Glycerolipid metabolism";"Monoacylglycerol metabolism (yeast)" XP_046736106.1 1 KEGG: 00970+6.3.5.7 "Aminoacyl-tRNA biosynthesis" XP_046751412.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" XP_046745878.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046736285.1 2 Reactome: R-HSA-418555;Reactome: R-HSA-419812 "G alpha (s) signalling events";"Calcitonin-like ligand receptors" XP_046738837.1 4 Reactome: R-HSA-156581;MetaCyc: PWY-5912;KEGG: 00270+2.5.1.6;MetaCyc: PWY-5041 "Methylation";"2'-deoxymugineic acid phytosiderophore biosynthesis";"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" XP_046741643.1 1 Reactome: R-HSA-6811438 "Intra-Golgi traffic" XP_046753715.1 11 Reactome: R-HSA-1912408;Reactome: R-HSA-6796648;Reactome: R-HSA-8862803;Reactome: R-HSA-9018519;Reactome: R-HSA-5617472;Reactome: R-HSA-5687128;Reactome: R-HSA-450341;Reactome: R-HSA-2559582;Reactome: R-HSA-2559580;Reactome: R-HSA-8943724;Reactome: R-HSA-2871796 "Pre-NOTCH Transcription and Translation";"TP53 Regulates Transcription of DNA Repair Genes";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Estrogen-dependent gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"MAPK6/MAPK4 signaling";"Activation of the AP-1 family of transcription factors";"Senescence-Associated Secretory Phenotype (SASP)";"Oxidative Stress Induced Senescence";"Regulation of PTEN gene transcription";"FCERI mediated MAPK activation" XP_046752389.1 1 Reactome: R-HSA-373080 "Class B/2 (Secretin family receptors)" XP_046744911.1 11 Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878 "Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport" XP_046749967.1 4 KEGG: 00640+1.2.1.27;MetaCyc: PWY-5642;Reactome: R-HSA-70895;KEGG: 00280+1.2.1.27 "Propanoate metabolism";"2,4-dinitrotoluene degradation";"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation" XP_046750386.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046741016.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046737457.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046746592.1 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" XP_046752147.1 6 KEGG: 00520+2.7.7.12;Reactome: R-HSA-70370;Reactome: R-HSA-5609978;MetaCyc: PWY-6317;MetaCyc: PWY-6527;KEGG: 00052+2.7.7.12 "Amino sugar and nucleotide sugar metabolism";"Galactose catabolism";"Defective GALT can cause Galactosemia";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Galactose metabolism" XP_046742285.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046743416.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046736503.1 2 Reactome: R-HSA-5663220;Reactome: R-HSA-376176 "RHO GTPases Activate Formins";"Signaling by ROBO receptors" XP_046739916.1 5 Reactome: R-HSA-3214858;Reactome: R-HSA-1266695;Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-3247509 "RMTs methylate histone arginines";"Interleukin-7 signaling";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"Chromatin modifying enzymes" XP_046751696.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046734351.1 2 KEGG: 00511+3.2.1.96;Reactome: R-HSA-532668 "Other glycan degradation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle" XP_046734493.1 12 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416476;Reactome: R-HSA-194840;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-418885;Reactome: R-HSA-193648 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"G alpha (12/13) signalling events";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"G alpha (q) signalling events";"Rho GTPase cycle";"Human papillomavirus infection";"Relaxin signaling pathway";"DCC mediated attractive signaling";"NRAGE signals death through JNK" XP_046738086.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046744070.1 3 KEGG: 00051+1.1.1.271;Reactome: R-HSA-6787639;KEGG: 00520+1.1.1.271 "Fructose and mannose metabolism";"GDP-fucose biosynthesis";"Amino sugar and nucleotide sugar metabolism" XP_046745356.1 2 Reactome: R-HSA-5576894;Reactome: R-HSA-1296072 "Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels" XP_046742012.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046738525.1 7 KEGG: 00280+4.1.3.4;MetaCyc: PWY-5074;Reactome: R-HSA-9033241;KEGG: 00650+4.1.3.4;Reactome: R-HSA-77111;KEGG: 00281+4.1.3.4;KEGG: 00072+4.1.3.4 "Valine, leucine and isoleucine degradation";"Mevalonate degradation";"Peroxisomal protein import";"Butanoate metabolism";"Synthesis of Ketone Bodies";"Geraniol degradation";"Synthesis and degradation of ketone bodies" XP_046740476.1 12 MetaCyc: PWY-7416;MetaCyc: PWY-7417;MetaCyc: PWY-8053;KEGG: 00564+3.1.1.4;KEGG: 00592+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783 "Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Arachidonic acid metabolism";"Plasmalogen degradation" XP_046737639.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046752344.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046739271.1 1 Reactome: R-HSA-70895 "Branched-chain amino acid catabolism" XP_046743835.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046752711.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046748514.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046736721.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046741365.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046746785.1 7 Reactome: R-HSA-2173796;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" XP_046743201.1 8 Reactome: R-HSA-6798695;Reactome: R-HSA-165159;Reactome: R-HSA-8943724;Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-9639288 "Neutrophil degranulation";"mTOR signalling";"Regulation of PTEN gene transcription";"Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"Amino acids regulate mTORC1" XP_046753969.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046738371.1 2 Reactome: R-HSA-174403;Reactome: R-HSA-5578998 "Glutathione synthesis and recycling";"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)" XP_046739183.1 2 Reactome: R-HSA-399719;Reactome: R-HSA-190873 "Trafficking of AMPA receptors";"Gap junction degradation" XP_046735138.1 2 KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710 "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)" XP_046751110.1 7 Reactome: R-HSA-76061;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-76071 "RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter" XP_046748031.1 7 Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518 "Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2" XP_046742742.1 2 KEGG: 00970+6.1.1.10;KEGG: 00450+6.1.1.10 "Aminoacyl-tRNA biosynthesis";"Selenocompound metabolism" XP_046745375.1 11 Reactome: R-HSA-2426168;Reactome: R-HSA-400206;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-1368108;Reactome: R-HSA-3214858;Reactome: R-HSA-6804114;Reactome: R-HSA-381340;Reactome: R-HSA-400253 "Activation of gene expression by SREBF (SREBP)";"Regulation of lipid metabolism by PPARalpha";"Estrogen-dependent gene expression";"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"RMTs methylate histone arginines";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock" XP_046742899.1 1 Reactome: R-HSA-140342 "Apoptosis induced DNA fragmentation" XP_046751016.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046739296.1 7 Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-5626467;Reactome: R-HSA-2500257 "Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion" XP_046737985.1 2 MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4 "Cellulose degradation II (fungi)";"Starch and sucrose metabolism" XP_046746208.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046743027.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046750572.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046743891.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046750709.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046742048.1 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" XP_046739450.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046737871.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046743890.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046737427.1 2 Reactome: R-HSA-983231;Reactome: R-HSA-383280 "Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway" XP_046748492.1 4 Reactome: R-HSA-196741;Reactome: R-HSA-3359462;Reactome: R-HSA-3359463;Reactome: R-HSA-8964011 "Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective AMN causes hereditary megaloblastic anemia 1";"Defective CUBN causes hereditary megaloblastic anemia 1";"HDL clearance" XP_046746843.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046749978.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046751398.1 2 Reactome: R-HSA-5693571;Reactome: R-HSA-164843 "Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation" XP_046742138.1 2 KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024 "Purine metabolism";"DARPP-32 events" XP_046736776.1 15 Reactome: R-HSA-5358752;Reactome: R-HSA-5467348;Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-5339716;Reactome: R-HSA-5689896;Reactome: R-HSA-5467333;Reactome: R-HSA-3769402;Reactome: R-HSA-195253;Reactome: R-HSA-111465;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-5467340 "T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"Misspliced GSK3beta mutants stabilize beta-catenin";"Ovarian tumor domain proteases";"APC truncation mutants are not K63 polyubiquitinated";"Deactivation of the beta-catenin transactivating complex";"Degradation of beta-catenin by the destruction complex";"Apoptotic cleavage of cellular proteins";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"AXIN missense mutants destabilize the destruction complex" XP_046752048.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046752380.1 3 Reactome: R-HSA-4090294;Reactome: R-HSA-3232118;Reactome: R-HSA-3899300 "SUMOylation of intracellular receptors";"SUMOylation of transcription factors";"SUMOylation of transcription cofactors" XP_046740405.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046752216.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046745488.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046750062.1 5 Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-201722;Reactome: R-HSA-8866654 "Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of the beta-catenin:TCF transactivating complex";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046752291.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046749848.1 6 KEGG: 05235+3.1.3.16;Reactome: R-HSA-163560;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-400253;Reactome: R-HSA-2173788 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"Triglyceride catabolism";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"Circadian Clock";"Downregulation of TGF-beta receptor signaling" XP_046748738.1 8 Reactome: R-HSA-8950505;MetaCyc: PWY-5723;Reactome: R-HSA-71336;Reactome: R-HSA-6791462;KEGG: 00030+2.2.1.2;Reactome: R-HSA-6791055;MetaCyc: PWY-1861;Reactome: R-HSA-163754 "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Rubisco shunt";"Pentose phosphate pathway";"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P";"Pentose phosphate pathway";"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Insulin effects increased synthesis of Xylulose-5-Phosphate" XP_046752922.1 3 Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621 "Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism" XP_046744994.1 3 Reactome: R-HSA-1592389;Reactome: R-HSA-1442490;Reactome: R-HSA-1474228 "Activation of Matrix Metalloproteinases";"Collagen degradation";"Degradation of the extracellular matrix" XP_046748904.1 26 Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-389977;Reactome: R-HSA-9648025;Reactome: R-HSA-389960;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257 "RHO GTPases Activate Formins";"Mitotic Prometaphase";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Aggrephagy";"COPI-mediated anterograde transport";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Post-chaperonin tubulin folding pathway";"EML4 and NUDC in mitotic spindle formation";"Formation of tubulin folding intermediates by CCT/TriC";"Separation of Sister Chromatids";"Cilium Assembly";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"HCMV Early Events";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion" XP_046741006.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046734770.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046743929.1 12 KEGG: 00561+2.7.7.9;MetaCyc: PWY-3801;KEGG: 00500+2.7.7.9;MetaCyc: PWY-7343;MetaCyc: PWY-7817;KEGG: 00052+2.7.7.9;MetaCyc: PWY-7238;KEGG: 00040+2.7.7.9;KEGG: 00520+2.7.7.9;Reactome: R-HSA-3322077;Reactome: R-HSA-173599;MetaCyc: PWY-6527 "Glycerolipid metabolism";"Sucrose degradation II (sucrose synthase)";"Starch and sucrose metabolism";"UDP-alpha-D-glucose biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Galactose metabolism";"Sucrose biosynthesis II";"Pentose and glucuronate interconversions";"Amino sugar and nucleotide sugar metabolism";"Glycogen synthesis";"Formation of the active cofactor, UDP-glucuronate";"Stachyose degradation" XP_046743782.1 1 Reactome: R-HSA-9617828 "FOXO-mediated transcription of cell cycle genes" XP_046741034.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046753815.1 5 Reactome: R-HSA-2559580;Reactome: R-HSA-2871796;Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450321 "Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation";"Activation of the AP-1 family of transcription factors";"mTOR signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" XP_046751698.1 15 Reactome: R-HSA-9029569;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459;Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723;Reactome: R-HSA-9018519;Reactome: R-HSA-5687128;Reactome: R-HSA-2559585;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation";"Estrogen-dependent gene expression";"MAPK6/MAPK4 signaling";"Oncogene Induced Senescence";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"Regulation of MECP2 expression and activity" XP_046745507.1 1 Reactome: R-HSA-8849175 "Threonine catabolism" XP_046736959.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046742708.1 6 Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68949 "Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Orc1 removal from chromatin" XP_046749783.1 5 Reactome: R-HSA-109704;Reactome: R-HSA-1257604;Reactome: R-HSA-5673001;Reactome: R-HSA-2219530;Reactome: R-HSA-6811558 "PI3K Cascade";"PIP3 activates AKT signaling";"RAF/MAP kinase cascade";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" XP_046746929.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046741094.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046741109.1 4 Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-8953750;Reactome: R-HSA-69202 "Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Transcriptional Regulation by E2F6";"Cyclin E associated events during G1/S transition" XP_046745193.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046736134.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046741255.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046744056.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046749305.1 3 Reactome: R-HSA-77588;Reactome: R-HSA-73856;Reactome: R-HSA-159230 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination";"Transport of the SLBP Dependant Mature mRNA" XP_046741048.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046744213.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046737808.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" XP_046741991.1 3 Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" XP_046744411.1 12 Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399 "COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy" XP_046743547.1 1 Reactome: R-HSA-8873719 "RAB geranylgeranylation" XP_046736278.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046735367.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046735297.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046749275.1 1 Reactome: R-HSA-418594 "G alpha (i) signalling events" XP_046744119.1 2 Reactome: R-HSA-5223345;Reactome: R-HSA-425393 "Miscellaneous transport and binding events";"Transport of inorganic cations/anions and amino acids/oligopeptides" XP_046752335.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046743355.1 5 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-159231 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript" XP_046744135.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046749652.1 8 KEGG: 00524+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00052+2.7.1.1;KEGG: 00010+2.7.1.1 "Neomycin, kanamycin and gentamicin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Starch and sucrose metabolism";"Fructose and mannose metabolism";"Streptomycin biosynthesis";"Glycolysis";"Galactose metabolism";"Glycolysis / Gluconeogenesis" XP_046740995.1 1 Reactome: R-HSA-6811434 "COPI-dependent Golgi-to-ER retrograde traffic" XP_046750422.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046749448.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" XP_046753932.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046740192.1 1 Reactome: R-HSA-433137 "Sodium-coupled sulphate, di- and tri-carboxylate transporters" XP_046749565.1 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" XP_046742199.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046746781.1 2 Reactome: R-HSA-6802953;Reactome: R-HSA-5658442 "RAS signaling downstream of NF1 loss-of-function variants";"Regulation of RAS by GAPs" XP_046739043.1 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" XP_046744057.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046739880.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046741065.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-8964539 "Transcriptional activation of mitochondrial biogenesis";"Glutamate and glutamine metabolism" XP_046745003.1 14 Reactome: R-HSA-5663220;Reactome: R-HSA-380270;Reactome: R-HSA-68877;Reactome: R-HSA-2565942;Reactome: R-HSA-9648025;Reactome: R-HSA-380284;Reactome: R-HSA-2467813;Reactome: R-HSA-5620912;Reactome: R-HSA-141444;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-8854518;Reactome: R-HSA-2500257 "RHO GTPases Activate Formins";"Recruitment of mitotic centrosome proteins and complexes";"Mitotic Prometaphase";"Regulation of PLK1 Activity at G2/M Transition";"EML4 and NUDC in mitotic spindle formation";"Loss of proteins required for interphase microtubule organization from the centrosome";"Separation of Sister Chromatids";"Anchoring of the basal body to the plasma membrane";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"AURKA Activation by TPX2";"Resolution of Sister Chromatid Cohesion" XP_046733735.1 1 Reactome: R-HSA-6804759 "Regulation of TP53 Activity through Association with Co-factors" XP_046747733.1 3 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046748038.1 2 Reactome: R-HSA-8951671;Reactome: R-HSA-2032785 "RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression" XP_046745318.1 14 Reactome: R-HSA-5628897;Reactome: R-HSA-8986944;Reactome: R-HSA-8934593;Reactome: R-HSA-1912408;Reactome: R-HSA-9029569;Reactome: R-HSA-426486;Reactome: R-HSA-203927;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723 "TP53 Regulates Metabolic Genes";"Transcriptional Regulation by MECP2";"Regulation of RUNX1 Expression and Activity";"Pre-NOTCH Transcription and Translation";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation" XP_046752982.1 1 Reactome: R-HSA-2142789 "Ubiquinol biosynthesis" XP_046751116.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046748368.1 1 Reactome: R-HSA-5683826 "Surfactant metabolism" XP_046736890.1 1 KEGG: 00970+6.1.1.20 "Aminoacyl-tRNA biosynthesis" XP_046744415.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046750630.1 1 Reactome: R-HSA-426486 "Small interfering RNA (siRNA) biogenesis" XP_046748733.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046741031.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046741155.1 6 KEGG: 04070+2.7.11.13;Reactome: R-HSA-5099900;Reactome: R-HSA-76005;Reactome: R-HSA-418597;Reactome: R-HSA-416993;Reactome: R-HSA-114516 "Phosphatidylinositol signaling system";"WNT5A-dependent internalization of FZD4";"Response to elevated platelet cytosolic Ca2+";"G alpha (z) signalling events";"Trafficking of GluR2-containing AMPA receptors";"Disinhibition of SNARE formation" XP_046745605.1 1 Reactome: R-HSA-5626467 "RHO GTPases activate IQGAPs" XP_046743865.1 24 Reactome: R-HSA-418555;Reactome: R-HSA-456926;Reactome: R-HSA-400042;Reactome: R-HSA-163359;Reactome: R-HSA-381676;Reactome: R-HSA-416476;Reactome: R-HSA-418217;Reactome: R-HSA-392451;Reactome: R-HSA-9009391;Reactome: R-HSA-418597;Reactome: R-HSA-416482;Reactome: R-HSA-432040;Reactome: R-HSA-500657;Reactome: R-HSA-8964315;Reactome: R-HSA-418592;Reactome: R-HSA-8964616;Reactome: R-HSA-4086398;Reactome: R-HSA-6814122;Reactome: R-HSA-392170;Reactome: R-HSA-428930;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-420092;Reactome: R-HSA-392851 "G alpha (s) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"Adrenaline,noradrenaline inhibits insulin secretion";"Glucagon signaling in metabolic regulation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G alpha (q) signalling events";"G beta:gamma signalling through PLC beta";"G beta:gamma signalling through PI3Kgamma";"Extra-nuclear estrogen signaling";"G alpha (z) signalling events";"G alpha (12/13) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Presynaptic function of Kainate receptors";"G beta:gamma signalling through BTK";"ADP signalling through P2Y purinoceptor 1";"G beta:gamma signalling through CDC42";"Ca2+ pathway";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"ADP signalling through P2Y purinoceptor 12";"Thromboxane signalling through TP receptor";"G alpha (i) signalling events";"G-protein activation";"Glucagon-type ligand receptors";"Prostacyclin signalling through prostacyclin receptor" XP_046739406.1 8 KEGG: 00230+2.7.4.8;Reactome: R-HSA-438066;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-9620244;MetaCyc: PWY-7221;Reactome: R-HSA-442982;Reactome: R-HSA-9617324 "Purine metabolism";"Unblocking of NMDA receptors, glutamate binding and activation";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"Long-term potentiation";"Guanosine ribonucleotides de novo biosynthesis";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission" XP_046748178.1 1 KEGG: 00531+3.2.1.35 "Glycosaminoglycan degradation" XP_046748990.1 3 Reactome: R-HSA-1236974;Reactome: R-HSA-9609523;Reactome: R-HSA-1799339 "ER-Phagosome pathway";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"SRP-dependent cotranslational protein targeting to membrane" XP_046753305.1 1 Reactome: R-HSA-2428928 "IRS-related events triggered by IGF1R" XP_046740088.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046747590.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046740216.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046751161.1 1 Reactome: R-HSA-1221632 "Meiotic synapsis" XP_046752744.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046747816.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046741729.1 1 Reactome: R-HSA-169911 "Regulation of Apoptosis" XP_046734144.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046745416.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046753814.1 5 Reactome: R-HSA-450321;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341;Reactome: R-HSA-2559580;Reactome: R-HSA-2871796 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"mTOR signaling pathway";"Activation of the AP-1 family of transcription factors";"Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation" XP_046736130.1 1 Reactome: R-HSA-420029 "Tight junction interactions" XP_046736688.1 4 Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" XP_046748897.1 3 Reactome: R-HSA-5620916;Reactome: R-HSA-1445148;Reactome: R-HSA-264876 "VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing" XP_046745443.1 16 Reactome: R-HSA-512988;Reactome: R-HSA-9009391;Reactome: R-HSA-1433557;Reactome: R-HSA-912526;Reactome: R-HSA-389357;Reactome: R-HSA-416476;Reactome: R-HSA-6811558;Reactome: R-HSA-1266695;Reactome: R-HSA-8853659;Reactome: R-HSA-1660499;Reactome: R-HSA-912631;Reactome: R-HSA-388841;Reactome: R-HSA-2219530;Reactome: R-HSA-194840;Reactome: R-HSA-114604;Reactome: R-HSA-1257604 "Interleukin-3, Interleukin-5 and GM-CSF signaling";"Extra-nuclear estrogen signaling";"Signaling by SCF-KIT";"Interleukin receptor SHC signaling";"CD28 dependent PI3K/Akt signaling";"G alpha (q) signalling events";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Interleukin-7 signaling";"RET signaling";"Synthesis of PIPs at the plasma membrane";"Regulation of signaling by CBL";"Costimulation by the CD28 family";"Constitutive Signaling by Aberrant PI3K in Cancer";"Rho GTPase cycle";"GPVI-mediated activation cascade";"PIP3 activates AKT signaling" XP_046741660.1 2 Reactome: R-HSA-373752;Reactome: R-HSA-525793 "Netrin-1 signaling";"Myogenesis" XP_046735976.1 1 Reactome: R-HSA-6809371 "Formation of the cornified envelope" XP_046744776.1 8 Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-3371571;Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-166208 "Regulation of PTEN gene transcription";"mTOR signalling";"Amino acids regulate mTORC1";"HSF1-dependent transactivation";"Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling" XP_046748578.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046735156.1 13 KEGG: 00740+3.6.1.9;MetaCyc: PWY-7187;KEGG: 00760+3.6.1.9;MetaCyc: PWY-7184;MetaCyc: PWY-7821;KEGG: 00500+3.6.1.9;KEGG: 00230+3.6.1.9;KEGG: 00770+3.6.1.9;MetaCyc: PWY-6545;KEGG: 00240+3.6.1.9;Reactome: R-HSA-74259;MetaCyc: PWY-7206;KEGG: 00230+3.6.1.66 "Riboflavin metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Nicotinate and nicotinamide metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Tunicamycin biosynthesis";"Starch and sucrose metabolism";"Purine metabolism";"Pantothenate and CoA biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Purine catabolism";"Pyrimidine deoxyribonucleotides dephosphorylation";"Purine metabolism" XP_046752559.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046749555.1 1 Reactome: R-HSA-6787450 "tRNA modification in the mitochondrion" XP_046738285.1 16 Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation" XP_046747281.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046741534.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-380095 "G alpha (q) signalling events";"Tachykinin receptors bind tachykinins" XP_046744058.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046746063.1 17 Reactome: R-HSA-5685938;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6796648;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693616;KEGG: 05170+2.7.11.1;Reactome: R-HSA-3371453;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-176187;Reactome: R-HSA-69473;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-1221632;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6783310 "HDR through Single Strand Annealing (SSA)";"Human papillomavirus infection";"Relaxin signaling pathway";"TP53 Regulates Transcription of DNA Repair Genes";"mTOR signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"Human immunodeficiency virus 1 infection";"Regulation of HSF1-mediated heat shock response";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Thermogenesis";"Human cytomegalovirus infection";"Meiotic synapsis";"PI3K-Akt signaling pathway";"Fanconi Anemia Pathway" XP_046750716.1 14 Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-167158;Reactome: R-HSA-167243 "Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery" XP_046753513.1 4 Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497 "COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)" XP_046746013.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046750922.1 3 KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596 "Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I" XP_046752796.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046753096.1 13 MetaCyc: PWY-6545;MetaCyc: PWY-7220;MetaCyc: PWY-7226;KEGG: 00983+1.17.4.1;KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-7222;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7227 "Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Drug metabolism - other enzymes";"Purine metabolism";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis" XP_046733723.1 4 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.6;Reactome: R-HSA-2408522;Reactome: R-HSA-379726 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation" XP_046734582.1 8 Reactome: R-HSA-165054;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444 "Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046753149.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046740987.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046747044.1 1 Reactome: R-HSA-400253 "Circadian Clock" XP_046738881.1 2 Reactome: R-HSA-2151201;KEGG: 00970+6.1.1.14 "Transcriptional activation of mitochondrial biogenesis";"Aminoacyl-tRNA biosynthesis" XP_046750737.1 7 Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-73780 "RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Chain Elongation" XP_046743084.1 1 Reactome: R-HSA-3108214 "SUMOylation of DNA damage response and repair proteins" XP_046744942.1 4 Reactome: R-HSA-1912420;Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837 "Pre-NOTCH Processing in Golgi";"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases" XP_046753353.1 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" XP_046753234.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046747535.1 3 Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-5578775 "Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Ion homeostasis" XP_046735155.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046744892.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046750245.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046748791.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046752186.1 3 MetaCyc: PWY-6368;MetaCyc: PWY-6367;KEGG: 04070+3.1.3.78 "3-phosphoinositide degradation";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system" XP_046753526.1 16 Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination" XP_046745952.1 2 Reactome: R-HSA-376176;Reactome: R-HSA-202433 "Signaling by ROBO receptors";"Generation of second messenger molecules" XP_046749229.1 4 Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-3769402 "Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex" XP_046737728.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046743852.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046750061.1 5 Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-8866654;Reactome: R-HSA-201722 "Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of the beta-catenin:TCF transactivating complex" XP_046753226.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046751498.1 4 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-76066 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" XP_046746082.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046737832.1 8 Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68689;Reactome: R-HSA-68867;Reactome: R-HSA-68616;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68827 "Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"CDC6 association with the ORC:origin complex";"Assembly of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex" XP_046741154.1 6 Reactome: R-HSA-76005;Reactome: R-HSA-5099900;KEGG: 04070+2.7.11.13;Reactome: R-HSA-416993;Reactome: R-HSA-114516;Reactome: R-HSA-418597 "Response to elevated platelet cytosolic Ca2+";"WNT5A-dependent internalization of FZD4";"Phosphatidylinositol signaling system";"Trafficking of GluR2-containing AMPA receptors";"Disinhibition of SNARE formation";"G alpha (z) signalling events" XP_046747018.1 2 Reactome: R-HSA-430039;Reactome: R-HSA-72163 "mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway" XP_046738487.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046745955.1 2 Reactome: R-HSA-376176;Reactome: R-HSA-202433 "Signaling by ROBO receptors";"Generation of second messenger molecules" XP_046751019.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046744466.1 4 KEGG: 00600+3.5.1.23;MetaCyc: PWY-6483;MetaCyc: PWY-7119;Reactome: R-HSA-1660662 "Sphingolipid metabolism";"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)";"Glycosphingolipid metabolism" XP_046752965.1 1 Reactome: R-HSA-112126 "ALKBH3 mediated reversal of alkylation damage" XP_046740496.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046745072.1 13 Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72706 "Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046752569.1 2 MetaCyc: PWY-7799;MetaCyc: PWY-7802 "Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)" XP_046739487.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046736497.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046734226.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046753279.1 2 Reactome: R-HSA-8949664;Reactome: R-HSA-8949215 "Processing of SMDT1";"Mitochondrial calcium ion transport" XP_046751633.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046746065.1 17 KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693616;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6796648;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5685938;Reactome: R-HSA-6783310;KEGG: 04151+2.7.11.1;Reactome: R-HSA-1221632;KEGG: 05163+2.7.11.1;Reactome: R-HSA-69473;KEGG: 04714+2.7.11.1;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-3371453 "Human immunodeficiency virus 1 infection";"Presynaptic phase of homologous DNA pairing and strand exchange";"mTOR signaling pathway";"TP53 Regulates Transcription of DNA Repair Genes";"Relaxin signaling pathway";"Human papillomavirus infection";"HDR through Single Strand Annealing (SSA)";"Fanconi Anemia Pathway";"PI3K-Akt signaling pathway";"Meiotic synapsis";"Human cytomegalovirus infection";"G2/M DNA damage checkpoint";"Thermogenesis";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Regulation of HSF1-mediated heat shock response" XP_046736397.1 17 Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-6790901;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649 "Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"rRNA modification in the nucleus and cytosol";"Peptide chain elongation";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation" XP_046739714.1 31 Reactome: R-HSA-163765;MetaCyc: PWY-7723;MetaCyc: PWY-5994;MetaCyc: PWY-7746;MetaCyc: PWY-5366;Reactome: R-HSA-199220;Reactome: R-HSA-9029558;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWY-7858;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-2426168;MetaCyc: PWY-5147;MetaCyc: PWY-6113;MetaCyc: PWY-7663;Reactome: R-HSA-75105;MetaCyc: PWY-5971;MetaCyc: PWY-7664;MetaCyc: PWY-5973;MetaCyc: PWY-6799;MetaCyc: PWY-4381;MetaCyc: PWY-7388;MetaCyc: PWY-5367;MetaCyc: PWY-5966-1;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWYG-321;MetaCyc: PWY-5989;MetaCyc: PWY-6282;MetaCyc: PWY-8047;MetaCyc: PWY-5142;MetaCyc: PWY-6519 "ChREBP activates metabolic gene expression";"Bacterial bioluminescence";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Mycobacterial sulfolipid biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Mupirocin biosynthesis";"Pederin biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Biotin metabolism";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis I (plants)";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"Fatty acyl-CoA biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis IV (anaerobic)";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis";"";"Stearate biosynthesis II (bacteria and plants)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Bryostatin biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"8-amino-7-oxononanoate biosynthesis I" XP_046746422.1 13 MetaCyc: PWY-6545;KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7220;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7226;Reactome: R-HSA-499943;MetaCyc: PWY-7210;MetaCyc: PWY-7184;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7222 "Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Glutathione metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II" XP_046742950.1 13 Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975957 "Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046742961.1 33 Reactome: R-HSA-6782210;Reactome: R-HSA-69202;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-69273;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-75953;Reactome: R-HSA-73762;Reactome: R-HSA-6796648;Reactome: R-HSA-167172;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-112382;Reactome: R-HSA-167161;Reactome: R-HSA-72086;Reactome: R-HSA-8939236;Reactome: R-HSA-73863;Reactome: R-HSA-113418;Reactome: R-HSA-73776;Reactome: R-HSA-427413;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-69231;Reactome: R-HSA-69656;Reactome: R-HSA-77075;Reactome: R-HSA-167246;Reactome: R-HSA-73772;Reactome: R-HSA-167162 "Gap-filling DNA repair synthesis and ligation in TC-NER";"Cyclin E associated events during G1/S transition";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Cyclin A/B1/B2 associated events during G2/M transition";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"Transcription of the HIV genome";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of RNA Pol II elongation complex";"HIV Transcription Initiation";"mRNA Capping";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Polymerase I Transcription Termination";"Formation of the Early Elongation Complex";"RNA Polymerase II Promoter Escape";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Cyclin D associated events in G1";"Cyclin A:Cdk2-associated events at S phase entry";"RNA Pol II CTD phosphorylation and interaction with CE";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase I Promoter Escape";"RNA Polymerase II HIV Promoter Escape" XP_046745954.1 2 Reactome: R-HSA-376176;Reactome: R-HSA-202433 "Signaling by ROBO receptors";"Generation of second messenger molecules" XP_046750478.1 6 Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72695 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex" XP_046740948.1 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" XP_046738570.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046746085.1 1 Reactome: R-HSA-1660662 "Glycosphingolipid metabolism" XP_046736820.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046751323.1 2 Reactome: R-HSA-426117;Reactome: R-HSA-5619039 "Cation-coupled Chloride cotransporters";"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)" XP_046753283.1 19 Reactome: R-HSA-438066;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-9649948;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5673000;Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-6802955;Reactome: R-HSA-5673001;Reactome: R-HSA-936837;Reactome: R-HSA-9022692;Reactome: R-HSA-6802946;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-9620244;Reactome: R-HSA-111932 "Unblocking of NMDA receptors, glutamate binding and activation";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Signaling downstream of RAS mutants";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"RAF activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"RAF/MAP kinase cascade";"Ion transport by P-type ATPases";"Regulation of MECP2 expression and activity";"Signaling by moderate kinase activity BRAF mutants";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB" XP_046737380.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046745619.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046734467.1 5 MetaCyc: PWY-6317;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6 "D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"D-galactose detoxification";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism" XP_046742017.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046747539.1 3 Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-5578775 "Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Ion homeostasis" XP_046748351.1 13 Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9633012 "L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046737671.1 2 Reactome: R-HSA-390471;Reactome: R-HSA-1660662 "Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism" XP_046740093.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046740920.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046750542.1 14 MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7724 "Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)" XP_046736654.1 1 Reactome: R-HSA-5389840 "Mitochondrial translation elongation" XP_046750823.1 8 Reactome: R-HSA-113501;Reactome: R-HSA-174430;Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-68952;Reactome: R-HSA-69183;Reactome: R-HSA-69166;Reactome: R-HSA-69091 "Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Telomere C-strand synthesis initiation";"Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"DNA replication initiation";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate";"Polymerase switching" XP_046750949.1 2 Reactome: R-HSA-6785470;Reactome: R-HSA-6784531 "tRNA processing in the mitochondrion";"tRNA processing in the nucleus" XP_046738947.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046741552.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046749962.1 9 Reactome: R-HSA-196780;MetaCyc: PWY-6146;Reactome: R-HSA-70263;KEGG: 00720+6.4.1.1;Reactome: R-HSA-3371599;MetaCyc: PWY-8086;KEGG: 00620+6.4.1.1;KEGG: 00020+6.4.1.1;MetaCyc: PWY-6142 "Biotin transport and metabolism";"Methanobacterium thermoautotrophicum biosynthetic metabolism";"Gluconeogenesis";"Carbon fixation pathways in prokaryotes";"Defective HLCS causes multiple carboxylase deficiency";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)" XP_046742826.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733 "Wax biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis" XP_046744897.1 18 KEGG: 00592+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-1482922;MetaCyc: PWY-7783;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7417;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;Reactome: R-HSA-1482788;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482925;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8051;Reactome: R-HSA-1482801 "alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PI";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Synthesis of PA";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Acyl chain remodelling of PC";"Arachidonic acid metabolism";"Acyl chain remodelling of PG";"Linoleic acid metabolism";"Anandamide biosynthesis I";"Acyl chain remodelling of PS" XP_046753603.1 4 KEGG: 00250+1.4.1.14;KEGG: 00910+1.4.1.14;Reactome: R-HSA-73621;MetaCyc: PWY-6963 "Alanine, aspartate and glutamate metabolism";"Nitrogen metabolism";"Pyrimidine catabolism";"Ammonia assimilation cycle I" XP_046744045.1 4 KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046740067.1 2 KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749 "Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I" XP_046745679.1 2 Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7 "Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis" XP_046749753.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046742013.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046734393.1 1 Reactome: R-HSA-9616222 "Transcriptional regulation of granulopoiesis" XP_046737411.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression";"PPARA activates gene expression" XP_046747914.1 2 Reactome: R-HSA-5620924;Reactome: R-HSA-5610787 "Intraflagellar transport";"Hedgehog 'off' state" XP_046744022.1 1 Reactome: R-HSA-2564830 "Cytosolic iron-sulfur cluster assembly" XP_046742890.1 4 Reactome: R-HSA-6807505;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "RNA polymerase II transcribes snRNA genes";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046752000.1 2 Reactome: R-HSA-6807505;Reactome: R-HSA-191859 "RNA polymerase II transcribes snRNA genes";"snRNP Assembly" XP_046751967.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046751680.1 2 Reactome: R-HSA-426486;Reactome: R-HSA-203927 "Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis" XP_046753243.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046753813.1 5 Reactome: R-HSA-450321;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341;Reactome: R-HSA-2871796;Reactome: R-HSA-2559580 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"mTOR signaling pathway";"Activation of the AP-1 family of transcription factors";"FCERI mediated MAPK activation";"Oxidative Stress Induced Senescence" XP_046735626.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046753018.1 13 MetaCyc: PWY-7822;MetaCyc: PWY-7883;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;Reactome: R-HSA-2160916;Reactome: R-HSA-1660662;Reactome: R-HSA-2022857;Reactome: R-HSA-2024101;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00511+3.2.1.52 "Chitin degradation III (Serratia)";"Anhydromuropeptides recycling II";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"Hyaluronan uptake and degradation";"Glycosphingolipid metabolism";"Keratan sulfate degradation";"CS/DS degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Other glycan degradation" XP_046738556.1 2 Reactome: R-HSA-9029569;Reactome: R-HSA-804914 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transport of fatty acids" XP_046746712.1 1 Reactome: R-HSA-525793 "Myogenesis" XP_046749970.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" XP_046737363.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046740951.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046735947.1 6 MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508 "Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis" XP_046741787.1 7 Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-165159 "Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTOR signalling" XP_046749972.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" XP_046735939.1 6 MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107 "Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system" XP_046746381.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046745418.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046740999.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046734224.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046750032.1 3 Reactome: R-HSA-6807878;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440 "COPI-mediated anterograde transport";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network" XP_046752906.1 1 Reactome: R-HSA-9037629 "Lewis blood group biosynthesis" XP_046736157.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046750842.1 5 Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-72163 "Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway" XP_046735836.1 1 Reactome: R-HSA-2564830 "Cytosolic iron-sulfur cluster assembly" XP_046742449.1 20 KEGG: 00640+1.3.3.6;MetaCyc: PWY-6920;MetaCyc: PWY-7288;MetaCyc: PWY-7338;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7340;MetaCyc: PWY-7726;MetaCyc: PWY-7574;Reactome: R-HSA-9033241;MetaCyc: PWY-7858;MetaCyc: PWY-735;MetaCyc: PWY-6837;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7291;MetaCyc: PWY-5136;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7007;MetaCyc: PWY-7854;MetaCyc: PWY-7606;MetaCyc: PWY-7337 "Propanoate metabolism";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"alpha-Linolenic acid metabolism";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Propanoyl-coa degradation II";"Peroxisomal protein import";"(5Z)-dodecenoate biosynthesis II";"Jasmonic acid biosynthesis";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Fatty acid degradation";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation II (plant peroxisome)";"beta-Alanine metabolism";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"10-cis-heptadecenoyl-CoA degradation (yeast)" XP_046735144.1 3 KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261;Reactome: R-HSA-75109 "Glycerolipid metabolism";"Glycerol degradation I";"Triglyceride biosynthesis" XP_046747915.1 2 Reactome: R-HSA-5610787;Reactome: R-HSA-5620924 "Hedgehog 'off' state";"Intraflagellar transport" XP_046742808.1 1 Reactome: R-HSA-525793 "Myogenesis" XP_046741012.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046744957.1 12 Reactome: R-HSA-5655302;Reactome: R-HSA-193648;Reactome: R-HSA-194840;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-1839117;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1 "Signaling by FGFR1 in disease";"NRAGE signals death through JNK";"Rho GTPase cycle";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Signaling by cytosolic FGFR1 fusion mutants";"Thermogenesis";"G alpha (12/13) signalling events";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway" XP_046744246.1 12 Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-9609690 "EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"HCMV Early Events" XP_046751956.1 1 Reactome: R-HSA-2129379 "Molecules associated with elastic fibres" XP_046748976.1 3 Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961 "Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II" XP_046748592.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046753933.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046740641.1 16 Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72764 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination" XP_046739321.1 5 Reactome: R-HSA-5685938;Reactome: R-HSA-5696395;Reactome: R-HSA-6783310;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135 "HDR through Single Strand Annealing (SSA)";"Formation of Incision Complex in GG-NER";"Fanconi Anemia Pathway";"Dual Incision in GG-NER";"Dual incision in TC-NER" XP_046746908.1 9 MetaCyc: PWY-8004;MetaCyc: PWY-7003;Reactome: R-HSA-70263;Reactome: R-HSA-70171;KEGG: 00010+1.2.1.12;MetaCyc: PWY-6901;KEGG: 00710+1.2.1.12;MetaCyc: PWY-1042;MetaCyc: PWY-5484 "Entner-Doudoroff pathway I";"Glycerol degradation to butanol";"Gluconeogenesis";"Glycolysis";"Glycolysis / Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Carbon fixation in photosynthetic organisms";"Glycolysis IV (plant cytosol)";"Glycolysis II (from fructose 6-phosphate)" XP_046745441.1 16 Reactome: R-HSA-1660499;Reactome: R-HSA-388841;Reactome: R-HSA-2219530;Reactome: R-HSA-912631;Reactome: R-HSA-194840;Reactome: R-HSA-1257604;Reactome: R-HSA-114604;Reactome: R-HSA-512988;Reactome: R-HSA-389357;Reactome: R-HSA-912526;Reactome: R-HSA-1433557;Reactome: R-HSA-9009391;Reactome: R-HSA-6811558;Reactome: R-HSA-416476;Reactome: R-HSA-8853659;Reactome: R-HSA-1266695 "Synthesis of PIPs at the plasma membrane";"Costimulation by the CD28 family";"Constitutive Signaling by Aberrant PI3K in Cancer";"Regulation of signaling by CBL";"Rho GTPase cycle";"PIP3 activates AKT signaling";"GPVI-mediated activation cascade";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"CD28 dependent PI3K/Akt signaling";"Interleukin receptor SHC signaling";"Signaling by SCF-KIT";"Extra-nuclear estrogen signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"G alpha (q) signalling events";"RET signaling";"Interleukin-7 signaling" XP_046738887.1 5 Reactome: R-HSA-73856;Reactome: R-HSA-72165;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA Splicing - Minor Pathway";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046740274.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046746221.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046735658.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046741770.1 2 KEGG: 00900+2.1.1.100;Reactome: R-HSA-163841 "Terpenoid backbone biosynthesis";"Gamma carboxylation, hypusine formation and arylsulfatase activation" XP_046753696.1 13 Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557 "Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis" XP_046736831.1 15 Reactome: R-HSA-5693571;Reactome: R-HSA-5693616;Reactome: R-HSA-2559586;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-5693548;Reactome: R-HSA-5685942;Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5685939;Reactome: R-HSA-912446;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938 "Nonhomologous End-Joining (NHEJ)";"Presynaptic phase of homologous DNA pairing and strand exchange";"DNA Damage/Telomere Stress Induced Senescence";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Sensing of DNA Double Strand Breaks";"HDR through Homologous Recombination (HRR)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"HDR through MMEJ (alt-NHEJ)";"Meiotic recombination";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)" XP_046736632.1 9 Reactome: R-HSA-68949;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68827;Reactome: R-HSA-68867;Reactome: R-HSA-69017;Reactome: R-HSA-68689 "Orc1 removal from chromatin";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the pre-replicative complex";"CDK-mediated phosphorylation and removal of Cdc6";"CDC6 association with the ORC:origin complex" XP_046743792.1 3 Reactome: R-HSA-450513;Reactome: R-HSA-430039;Reactome: R-HSA-450385 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" XP_046751711.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" XP_046749228.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex" XP_046738002.1 5 KEGG: 00020+4.1.1.32;Reactome: R-HSA-70263;MetaCyc: PWY-7383;KEGG: 00010+4.1.1.32;KEGG: 00620+4.1.1.32 "Citrate cycle (TCA cycle)";"Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism" XP_046750970.1 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" XP_046741402.1 4 Reactome: R-HSA-2408557;KEGG: 00970+6.1.1.11;MetaCyc: PWY-6281;Reactome: R-HSA-379716 "Selenocysteine synthesis";"Aminoacyl-tRNA biosynthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Cytosolic tRNA aminoacylation" XP_046739749.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046740360.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046734868.1 7 Reactome: R-HSA-8964208;KEGG: 00790+1.14.16.1;MetaCyc: PWY-6134;KEGG: 00400+1.14.16.1;MetaCyc: PWY-7158;KEGG: 00360+1.14.16.1;Reactome: R-HSA-2160456 "Phenylalanine metabolism";"Folate biosynthesis";"L-tyrosine biosynthesis IV";"Phenylalanine, tyrosine and tryptophan biosynthesis";"L-phenylalanine degradation V";"Phenylalanine metabolism";"Phenylketonuria" XP_046745429.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase" XP_046737397.1 7 Reactome: R-HSA-203927;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-180746;Reactome: R-HSA-1655829;Reactome: R-HSA-5578749;Reactome: R-HSA-6784531 "MicroRNA (miRNA) biogenesis";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear import of Rev protein";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Transcriptional regulation by small RNAs";"tRNA processing in the nucleus" XP_046747721.1 2 Reactome: R-HSA-5173214;Reactome: R-HSA-5083635 "O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)" XP_046748387.1 27 Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-159227;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-3108214;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-168271;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168276 "Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways" XP_046737635.1 57 Reactome: R-HSA-174113;Reactome: R-HSA-6798695;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-450408;Reactome: R-HSA-4641257;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-8939902;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-9010553;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-1236974;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-202424;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-180585;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-5607761 "SCF-beta-TrCP mediated degradation of Emi1";"Neutrophil degranulation";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX2 expression and activity";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"Regulation of expression of SLITs and ROBOs";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"ER-Phagosome pathway";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Downstream TCR signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Vif-mediated degradation of APOBEC3G";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Dectin-1 mediated noncanonical NF-kB signaling" XP_046747806.1 8 Reactome: R-HSA-5140745;Reactome: R-HSA-8856825;Reactome: R-HSA-432720;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-5099900;Reactome: R-HSA-8856828;Reactome: R-HSA-3928665 "WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Cargo recognition for clathrin-mediated endocytosis";"Lysosome Vesicle Biogenesis";"Gap junction degradation";"Formation of annular gap junctions";"WNT5A-dependent internalization of FZD4";"Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells" XP_046738505.1 13 Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956 "Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" XP_046739521.1 3 Reactome: R-HSA-6798695;Reactome: R-HSA-264870;Reactome: R-HSA-6794361 "Neutrophil degranulation";"Caspase-mediated cleavage of cytoskeletal proteins";"Neurexins and neuroligins" XP_046738165.1 1 Reactome: R-HSA-176974 "Unwinding of DNA" XP_046753352.1 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" XP_046749377.1 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" XP_046744338.1 13 Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-6791226 "Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046747903.1 5 MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109 "Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis" XP_046733768.1 14 MetaCyc: PWY-6598;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7035;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7724 "Sciadonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)" XP_046750866.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" XP_046740106.1 2 Reactome: R-HSA-381340;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression" XP_046735996.1 9 Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-6807505;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-674695 "RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events" XP_046738168.1 7 Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-4615885;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257 "EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"SUMOylation of DNA replication proteins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion" XP_046743744.1 4 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046750310.1 5 MetaCyc: PWY-6855;MetaCyc: PWY-6906;KEGG: 00520+3.5.99.6;MetaCyc: PWY-5514;Reactome: R-HSA-70171 "Chitin degradation I (archaea)";"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Glycolysis" XP_046749566.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046736786.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046738234.1 3 KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046734171.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046751629.1 4 Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-5696395 "Dual Incision in GG-NER";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Formation of Incision Complex in GG-NER" XP_046744069.1 3 KEGG: 00520+1.1.1.271;KEGG: 00051+1.1.1.271;Reactome: R-HSA-6787639 "Amino sugar and nucleotide sugar metabolism";"Fructose and mannose metabolism";"GDP-fucose biosynthesis" XP_046734266.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046751989.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046753002.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046738367.1 6 Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-429958;Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-450604 "ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA" XP_046753485.1 8 Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-6798695;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-5620912 "AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Neutrophil degranulation";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane" XP_046747029.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046752951.1 13 Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764 "GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination" XP_046748465.1 1 Reactome: R-HSA-611105 "Respiratory electron transport" XP_046745274.1 5 Reactome: R-HSA-166166;Reactome: R-HSA-168164;Reactome: R-HSA-937072;Reactome: R-HSA-936964;Reactome: R-HSA-937041 "MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1" XP_046744320.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046753634.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" XP_046745891.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046748244.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-8873719 "RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation" XP_046743095.1 7 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046753672.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046735211.1 1 Reactome: R-HSA-71403 "Citric acid cycle (TCA cycle)" XP_046734810.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046746653.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046749393.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046734267.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046751488.1 5 Reactome: R-HSA-5663213;Reactome: R-HSA-6798695;Reactome: R-HSA-8856828;Reactome: R-HSA-3928662;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"Neutrophil degranulation";"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation" XP_046744961.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046741922.1 14 MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041 "Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis" XP_046749048.1 7 Reactome: R-HSA-204174;Reactome: R-HSA-389661;Reactome: R-HSA-70268;KEGG: 00620+2.3.1.12;Reactome: R-HSA-5362517;KEGG: 00020+2.3.1.12;KEGG: 00010+2.3.1.12 "Regulation of pyruvate dehydrogenase (PDH) complex";"Glyoxylate metabolism and glycine degradation";"Pyruvate metabolism";"Pyruvate metabolism";"Signaling by Retinoic Acid";"Citrate cycle (TCA cycle)";"Glycolysis / Gluconeogenesis" XP_046752342.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046738559.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046749398.1 4 Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-3769402 "Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex" XP_046743158.1 7 KEGG: 00195+7.1.2.2;Reactome: R-HSA-1268020;Reactome: R-HSA-8949613;KEGG: 00190+7.1.2.2;Reactome: R-HSA-2151201;MetaCyc: PWY-7980;Reactome: R-HSA-163210 "Photosynthesis";"Mitochondrial protein import";"Cristae formation";"Oxidative phosphorylation";"Transcriptional activation of mitochondrial biogenesis";"ATP biosynthesis";"Formation of ATP by chemiosmotic coupling" XP_046748898.1 3 Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing" XP_046747021.1 11 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2559580;Reactome: R-HSA-450302;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-4420097 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Oxidative Stress Induced Senescence";"activated TAK1 mediates p38 MAPK activation";"Relaxin signaling pathway";"Human papillomavirus infection";"p38MAPK events";"VEGFA-VEGFR2 Pathway" XP_046750407.1 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" XP_046748108.1 2 Reactome: R-HSA-4641265;Reactome: R-HSA-5339700 "Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP" XP_046745818.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046740784.1 2 KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1 "Pentose phosphate pathway";"Purine metabolism" XP_046739400.1 8 Reactome: R-HSA-9620244;MetaCyc: PWY-7221;Reactome: R-HSA-9617324;Reactome: R-HSA-442982;KEGG: 00230+2.7.4.8;Reactome: R-HSA-438066;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001 "Long-term potentiation";"Guanosine ribonucleotides de novo biosynthesis";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Ras activation upon Ca2+ influx through NMDA receptor";"Purine metabolism";"Unblocking of NMDA receptors, glutamate binding and activation";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade" XP_046739539.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046749072.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046753359.1 5 Reactome: R-HSA-171007;Reactome: R-HSA-4420097;Reactome: R-HSA-168638;KEGG: 04150+2.7.11.24;Reactome: R-HSA-376172 "p38MAPK events";"VEGFA-VEGFR2 Pathway";"NOD1/2 Signaling Pathway";"mTOR signaling pathway";"DSCAM interactions" XP_046738974.1 22 MetaCyc: PWY-5384;MetaCyc: PWY-6992;MetaCyc: PWY-7238;Reactome: R-HSA-6798695;KEGG: 00010+5.3.1.9;MetaCyc: PWY-5514;MetaCyc: PWY-7347;Reactome: R-HSA-70263;KEGG: 00520+5.3.1.9;Reactome: R-HSA-5628897;MetaCyc: PWY-622;MetaCyc: PWY-6981;MetaCyc: PWY-6142;MetaCyc: PWY-5054;MetaCyc: PWY-7385;MetaCyc: PWY-8013;Reactome: R-HSA-70171;MetaCyc: PWY-621;KEGG: 00500+5.3.1.9;MetaCyc: PWY-3801;MetaCyc: PWY-5659;KEGG: 00030+5.3.1.9 "Sucrose degradation IV (sucrose phosphorylase)";"1,5-anhydrofructose degradation";"Sucrose biosynthesis II";"Neutrophil degranulation";"Glycolysis / Gluconeogenesis";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Sucrose biosynthesis III";"Gluconeogenesis";"Amino sugar and nucleotide sugar metabolism";"TP53 Regulates Metabolic Genes";"Starch biosynthesis";"Chitin biosynthesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"D-sorbitol biosynthesis I";"1,3-propanediol biosynthesis (engineered)";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Glycolysis";"Sucrose degradation III (sucrose invertase)";"Starch and sucrose metabolism";"Sucrose degradation II (sucrose synthase)";"GDP-mannose biosynthesis";"Pentose phosphate pathway" XP_046751626.1 1 Reactome: R-HSA-69273 "Cyclin A/B1/B2 associated events during G2/M transition" XP_046747384.1 6 KEGG: 00230+3.5.4.3;Reactome: R-HSA-74259;MetaCyc: PWY-7442;MetaCyc: PWY-6608;MetaCyc: PWY-6606;MetaCyc: PWY-5497 "Purine metabolism";"Purine catabolism";"Drosopterin and aurodrosopterin biosynthesis";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Purine nucleobases degradation II (anaerobic)" XP_046749001.1 1 Reactome: R-HSA-8964038 "LDL clearance" XP_046736557.1 3 KEGG: 00232+1.7.3.3;MetaCyc: PWY-5691;KEGG: 00230+1.7.3.3 "Caffeine metabolism";"Urate conversion to allantoin I";"Purine metabolism" XP_046738131.1 2 Reactome: R-HSA-416993;Reactome: R-HSA-202733 "Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall" XP_046737239.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046736984.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046746312.1 1 Reactome: R-HSA-69273 "Cyclin A/B1/B2 associated events during G2/M transition" XP_046733948.1 8 KEGG: 00270+1.1.1.27;MetaCyc: PWY-6901;MetaCyc: PWY-5481;MetaCyc: PWY-8086;KEGG: 00640+1.1.1.27;Reactome: R-HSA-70268;KEGG: 00010+1.1.1.27;KEGG: 00620+1.1.1.27 "Cysteine and methionine metabolism";"Superpathway of glucose and xylose degradation";"Pyruvate fermentation to (S)-lactate";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Propanoate metabolism";"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism" XP_046737273.1 25 Reactome: R-HSA-392851;Reactome: R-HSA-420092;Reactome: R-HSA-202040;Reactome: R-HSA-418594;Reactome: R-HSA-381771;Reactome: R-HSA-428930;Reactome: R-HSA-6814122;Reactome: R-HSA-392170;Reactome: R-HSA-4086398;Reactome: R-HSA-8964616;Reactome: R-HSA-418592;Reactome: R-HSA-8964315;Reactome: R-HSA-500657;Reactome: R-HSA-416482;Reactome: R-HSA-432040;Reactome: R-HSA-418597;Reactome: R-HSA-9009391;Reactome: R-HSA-392451;Reactome: R-HSA-418217;Reactome: R-HSA-416476;Reactome: R-HSA-381676;Reactome: R-HSA-163359;Reactome: R-HSA-400042;Reactome: R-HSA-456926;Reactome: R-HSA-418555 "Prostacyclin signalling through prostacyclin receptor";"Glucagon-type ligand receptors";"G-protein activation";"G alpha (i) signalling events";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Thromboxane signalling through TP receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"ADP signalling through P2Y purinoceptor 12";"Ca2+ pathway";"G beta:gamma signalling through CDC42";"ADP signalling through P2Y purinoceptor 1";"G beta:gamma signalling through BTK";"Presynaptic function of Kainate receptors";"G alpha (12/13) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events";"Extra-nuclear estrogen signaling";"G beta:gamma signalling through PI3Kgamma";"G beta:gamma signalling through PLC beta";"G alpha (q) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Glucagon signaling in metabolic regulation";"Adrenaline,noradrenaline inhibits insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (s) signalling events" XP_046741010.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046751975.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046745940.1 2 Reactome: R-HSA-2682334;Reactome: R-HSA-3928665 "EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells" XP_046743636.1 3 MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167 "Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol" XP_046749884.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046744476.1 12 KEGG: 00670+2.1.2.2;MetaCyc: PWY-6277;MetaCyc: PWY-6122;Reactome: R-HSA-196780;KEGG: 00670+2.1.2.9;Reactome: R-HSA-73817;KEGG: 00970+2.1.2.9;KEGG: 00230+6.3.3.1;MetaCyc: PWY-6613;KEGG: 00230+2.1.2.2;KEGG: 00230+6.3.4.13;MetaCyc: PWY-6121 "One carbon pool by folate";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Biotin transport and metabolism";"One carbon pool by folate";"Purine ribonucleoside monophosphate biosynthesis";"Aminoacyl-tRNA biosynthesis";"Purine metabolism";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Purine metabolism";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I" XP_046748177.1 33 Reactome: R-HSA-141444;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-2500257;Reactome: R-HSA-168271;Reactome: R-HSA-5578749;Reactome: R-HSA-5663220;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-159227;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-9609690;Reactome: R-HSA-168276;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-5619107;Reactome: R-HSA-1169408 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Resolution of Sister Chromatid Cohesion";"Transport of Ribonucleoproteins into the Host Nucleus";"Transcriptional regulation by small RNAs";"RHO GTPases Activate Formins";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"Transport of the SLBP independent Mature mRNA";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Early Events";"NS1 Mediated Effects on Host Pathways";"Nuclear import of Rev protein";"Mitotic Prometaphase";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"ISG15 antiviral mechanism" XP_046740102.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046753835.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046743671.1 1 Reactome: R-HSA-2559584 "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" XP_046739068.1 9 MetaCyc: PWY-5789;MetaCyc: PWY-7115;MetaCyc: PWY-241;MetaCyc: PWY-6142;MetaCyc: PWY-5744;MetaCyc: PWY-5743;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7117;Reactome: R-HSA-1475029 "3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glyoxylate assimilation";"3-hydroxypropanoate cycle";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Reversible hydration of carbon dioxide" XP_046744862.1 3 Reactome: R-HSA-196741;Reactome: R-HSA-3359471;KEGG: 00860+2.5.1.17 "Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective MMAB causes methylmalonic aciduria type cblB";"Porphyrin and chlorophyll metabolism" XP_046740330.1 6 Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-456926;Reactome: R-HSA-399997 "G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Thrombin signalling through proteinase activated receptors (PARs)";"Acetylcholine regulates insulin secretion" XP_046742670.1 4 Reactome: R-HSA-3232142;Reactome: R-HSA-983168;Reactome: R-HSA-1234176;Reactome: R-HSA-8951664 "SUMOylation of ubiquitinylation proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Neddylation" XP_046746973.1 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" XP_046748141.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" XP_046747725.1 3 KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" XP_046742004.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046738804.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046749226.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-201722 "Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex" XP_046733772.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046747642.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046753838.1 2 Reactome: R-HSA-72165;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" XP_046747624.1 2 Reactome: R-HSA-5357905;Reactome: R-HSA-8876198 "Regulation of TNFR1 signaling";"RAB GEFs exchange GTP for GDP on RABs" XP_046750125.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046741027.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046739789.1 6 Reactome: R-HSA-69166;Reactome: R-HSA-110362;Reactome: R-HSA-162594;Reactome: R-HSA-5651801;Reactome: R-HSA-174437;Reactome: R-HSA-5685939 "Removal of the Flap Intermediate";"POLB-Dependent Long Patch Base Excision Repair";"Early Phase of HIV Life Cycle";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate from the C-strand";"HDR through MMEJ (alt-NHEJ)" XP_046744770.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046752926.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-375276 "G alpha (q) signalling events";"Peptide ligand-binding receptors" XP_046742167.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046742744.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046737155.1 9 Reactome: R-HSA-110357;Reactome: R-HSA-9608290;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-9630222;Reactome: R-HSA-110330;Reactome: R-HSA-110328;Reactome: R-HSA-9608287;Reactome: R-HSA-9630221 "Displacement of DNA glycosylase by APEX1";"Defective MUTYH substrate processing";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Defective NTHL1 substrate binding";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective MUTYH substrate binding";"Defective NTHL1 substrate processing" XP_046748971.1 3 MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783 "Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis" XP_046753922.1 1 Reactome: R-HSA-5250924 "B-WICH complex positively regulates rRNA expression" XP_046740764.1 1 Reactome: R-HSA-6785807 "Interleukin-4 and Interleukin-13 signaling" XP_046744696.1 1 Reactome: R-HSA-4615885 "SUMOylation of DNA replication proteins" XP_046754072.1 9 KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883 "Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II" XP_046745708.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046742245.1 2 Reactome: R-HSA-917729;Reactome: R-HSA-9610379 "Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events" XP_046734375.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046737633.1 9 Reactome: R-HSA-2426168;Reactome: R-HSA-191859;Reactome: R-HSA-1989781;Reactome: R-HSA-400206;Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-381340;Reactome: R-HSA-400253 "Activation of gene expression by SREBF (SREBP)";"snRNP Assembly";"PPARA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock" XP_046743655.1 7 MetaCyc: PWY-5469;MetaCyc: PWY-6824;MetaCyc: PWY-7214;MetaCyc: PWY-7445;MetaCyc: PWY-5466;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461 "Sesamin biosynthesis";"Justicidin B biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Luteolin triglucuronide degradation";"Matairesinol biosynthesis";"Phenylpropanoid biosynthesis";"Betanidin degradation" XP_046742927.1 1 Reactome: R-HSA-71384 "Ethanol oxidation" XP_046744031.1 8 Reactome: R-HSA-68867;Reactome: R-HSA-68616;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68689;Reactome: R-HSA-68949;Reactome: R-HSA-176187 "Assembly of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"CDC6 association with the ORC:origin complex";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress" XP_046751431.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046746838.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046742029.1 5 MetaCyc: PWY-5381;Reactome: R-HSA-197264;KEGG: 00760+6.3.4.21;Reactome: R-HSA-1368108;Reactome: R-HSA-6798695 "Pyridine nucleotide cycling (plants)";"Nicotinamide salvaging";"Nicotinate and nicotinamide metabolism";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Neutrophil degranulation" XP_046745766.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046735105.1 3 MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51;Reactome: R-HSA-6798695 "Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Neutrophil degranulation" XP_046735480.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046734776.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046737381.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046734379.1 5 Reactome: R-HSA-9615710;Reactome: R-HSA-917729;Reactome: R-HSA-174490;Reactome: R-HSA-162588;Reactome: R-HSA-9610379 "Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Membrane binding and targetting of GAG proteins";"Budding and maturation of HIV virion";"HCMV Late Events" XP_046748293.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046740959.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046737347.1 16 MetaCyc: PWY-8004;MetaCyc: PWY-5723;Reactome: R-HSA-70263;MetaCyc: PWY-7003;KEGG: 00680+4.2.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-7124;KEGG: 00010+4.2.1.11;Reactome: R-HSA-70171;MetaCyc: PWY-7218;MetaCyc: PWY-1622;MetaCyc: PWY-6901;MetaCyc: PWY-6142;MetaCyc: PWY-2221;MetaCyc: PWY-1042;MetaCyc: PWY-6886 "Entner-Doudoroff pathway I";"Rubisco shunt";"Gluconeogenesis";"Glycerol degradation to butanol";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Ethylene biosynthesis V (engineered)";"Glycolysis / Gluconeogenesis";"Glycolysis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Formaldehyde assimilation I (serine pathway)";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Glycolysis IV (plant cytosol)";"1-butanol autotrophic biosynthesis (engineered)" XP_046746630.1 11 Reactome: R-HSA-163615;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555;Reactome: R-HSA-170670;Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-5610787 "PKA activation";"G alpha (z) signalling events";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"Purine metabolism";"G alpha (s) signalling events";"Adenylate cyclase inhibitory pathway";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"Hedgehog 'off' state" XP_046749044.1 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" XP_046741758.1 11 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-380972;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-9614657;KEGG: 04926+2.7.11.1;Reactome: R-HSA-163680;Reactome: R-HSA-6804756;KEGG: 05165+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Energy dependent regulation of mTOR by LKB1-AMPK";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"FOXO-mediated transcription of cell death genes";"Relaxin signaling pathway";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation";"Human papillomavirus infection" XP_046740006.1 1 Reactome: R-HSA-3108214 "SUMOylation of DNA damage response and repair proteins" XP_046734515.1 2 Reactome: R-HSA-4090294;Reactome: R-HSA-383280 "SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway" XP_046735491.1 4 Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046737416.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression";"PPARA activates gene expression" XP_046751777.1 1 Reactome: R-HSA-391908 "Prostanoid ligand receptors" XP_046745810.1 10 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-444257;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-442742;Reactome: R-HSA-437239 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"RSK activation";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling";"Recycling pathway of L1" XP_046739241.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046735990.1 2 Reactome: R-HSA-1483115;Reactome: R-HSA-1483152 "Hydrolysis of LPC";"Hydrolysis of LPE" XP_046745472.1 5 MetaCyc: PWY-6891;KEGG: 00900+2.2.1.7;KEGG: 00730+2.2.1.7;MetaCyc: PWY-7560;MetaCyc: PWY-6892 "Thiazole biosynthesis II (aerobic bacteria)";"Terpenoid backbone biosynthesis";"Thiamine metabolism";"Methylerythritol phosphate pathway II";"Thiazole biosynthesis I (facultative anaerobic bacteria)" XP_046740445.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046735123.1 3 Reactome: R-HSA-9033241;Reactome: R-HSA-9603798;Reactome: R-HSA-8866654 "Peroxisomal protein import";"Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046753292.1 19 Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-9649948;Reactome: R-HSA-438066;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-6802952;Reactome: R-HSA-5673000;Reactome: R-HSA-3371571;Reactome: R-HSA-9617324;Reactome: R-HSA-6802946;Reactome: R-HSA-111932;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001;Reactome: R-HSA-936837;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692 "Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"Signaling downstream of RAS mutants";"Unblocking of NMDA receptors, glutamate binding and activation";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Signaling by BRAF and RAF fusions";"RAF activation";"HSF1-dependent transactivation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by moderate kinase activity BRAF mutants";"CaMK IV-mediated phosphorylation of CREB";"Long-term potentiation";"RAF/MAP kinase cascade";"Ion transport by P-type ATPases";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity" XP_046745461.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046751971.1 2 Reactome: R-HSA-5578775;Reactome: R-HSA-2672351 "Ion homeostasis";"Stimuli-sensing channels" XP_046735119.1 16 Reactome: R-HSA-177504;Reactome: R-HSA-167590;Reactome: R-HSA-8964038;Reactome: R-HSA-5140745;Reactome: R-HSA-437239;Reactome: R-HSA-182218;Reactome: R-HSA-5099900;Reactome: R-HSA-2132295;Reactome: R-HSA-8866427;Reactome: R-HSA-190873;Reactome: R-HSA-8856825;Reactome: R-HSA-416993;Reactome: R-HSA-8856828;Reactome: R-HSA-3928665;Reactome: R-HSA-164939;Reactome: R-HSA-196025 "Retrograde neurotrophin signalling";"Nef Mediated CD4 Down-regulation";"LDL clearance";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Recycling pathway of L1";"Nef Mediated CD8 Down-regulation";"WNT5A-dependent internalization of FZD4";"MHC class II antigen presentation";"VLDLR internalisation and degradation";"Gap junction degradation";"Cargo recognition for clathrin-mediated endocytosis";"Trafficking of GluR2-containing AMPA receptors";"Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"Nef mediated downregulation of CD28 cell surface expression";"Formation of annular gap junctions" XP_046751091.1 1 Reactome: R-HSA-2142789 "Ubiquinol biosynthesis" XP_046747788.1 3 Reactome: R-HSA-5626978;Reactome: R-HSA-193681;Reactome: R-HSA-1660662 "TNFR1-mediated ceramide production";"Ceramide signalling";"Glycosphingolipid metabolism" XP_046740950.1 1 Reactome: R-HSA-390651 "Dopamine receptors" XP_046736563.1 13 KEGG: 00511+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;Reactome: R-HSA-2160916;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883;MetaCyc: PWY-7822 "Other glycan degradation";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"CS/DS degradation";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Hyaluronan uptake and degradation";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Chitin degradation III (Serratia)" XP_046740884.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046741044.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046743108.1 40 Reactome: R-HSA-6803529;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-9018519;Reactome: R-HSA-6796648;Reactome: R-HSA-75953;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-75955;Reactome: R-HSA-6782210;Reactome: R-HSA-72203;Reactome: R-HSA-167162;Reactome: R-HSA-5601884;Reactome: R-HSA-167246;Reactome: R-HSA-5617472;Reactome: R-HSA-77075;Reactome: R-HSA-5578749;Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-203927;Reactome: R-HSA-73776;Reactome: R-HSA-72165;Reactome: R-HSA-8851708;Reactome: R-HSA-113418;Reactome: R-HSA-167238;Reactome: R-HSA-72163;Reactome: R-HSA-167161;Reactome: R-HSA-167287;Reactome: R-HSA-168325;Reactome: R-HSA-72086 "FGFR2 alternative splicing";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"Estrogen-dependent gene expression";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II HIV Promoter Escape";"PIWI-interacting RNA (piRNA) biogenesis";"Tat-mediated elongation of the HIV-1 transcript";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcriptional regulation by small RNAs";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"MicroRNA (miRNA) biogenesis";"RNA Polymerase II Promoter Escape";"mRNA Splicing - Minor Pathway";"Signaling by FGFR2 IIIa TM";"Formation of the Early Elongation Complex";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Major Pathway";"HIV Transcription Initiation";"HIV elongation arrest and recovery";"Viral Messenger RNA Synthesis";"mRNA Capping" XP_046746273.1 5 KEGG: 00270+2.1.1.37;Reactome: R-HSA-427413;Reactome: R-HSA-212300;Reactome: R-HSA-5334118;Reactome: R-HSA-4655427 "Cysteine and methionine metabolism";"NoRC negatively regulates rRNA expression";"PRC2 methylates histones and DNA";"DNA methylation";"SUMOylation of DNA methylation proteins" XP_046746227.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046747737.1 5 KEGG: 00562+3.1.3.64;MetaCyc: PWY-6368;MetaCyc: PWY-6580;KEGG: 04070+3.1.3.64;Reactome: R-HSA-1660499 "Inositol phosphate metabolism";"3-phosphoinositide degradation";"Phosphatidylinositol biosynthesis I (bacteria)";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane" XP_046738365.1 1 Reactome: R-HSA-433137 "Sodium-coupled sulphate, di- and tri-carboxylate transporters" XP_046737727.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046741180.1 13 Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-9633012;Reactome: R-HSA-156902 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation" XP_046735492.1 4 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046741275.1 19 Reactome: R-HSA-71403;Reactome: R-HSA-163765;KEGG: 00020+2.3.3.8;MetaCyc: PWY-6728;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5913;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-5172;MetaCyc: PWY-6969;MetaCyc: PWY-5537;Reactome: R-HSA-75105;Reactome: R-HSA-6798695;KEGG: 00640+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-7384;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5538;MetaCyc: PWY-5690 "Citric acid cycle (TCA cycle)";"ChREBP activates metabolic gene expression";"Citrate cycle (TCA cycle)";"Methylaspartate cycle";"Carbon fixation pathways in prokaryotes";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"Reductive TCA cycle II";"Acetyl-coa biosynthesis III (from citrate)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate V";"Fatty acyl-CoA biosynthesis";"Neutrophil degranulation";"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate VI";"TCA cycle II (plants and fungi)" XP_046745062.1 13 Reactome: R-HSA-8943724;Reactome: R-HSA-1257604;Reactome: R-HSA-165159;Reactome: R-HSA-389357;Reactome: R-HSA-6804757;Reactome: R-HSA-9639288;Reactome: R-HSA-3371571;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-5674400;Reactome: R-HSA-1632852;Reactome: R-HSA-5218920 "Regulation of PTEN gene transcription";"PIP3 activates AKT signaling";"mTOR signalling";"CD28 dependent PI3K/Akt signaling";"Regulation of TP53 Degradation";"Amino acids regulate mTORC1";"HSF1-dependent transactivation";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Constitutive Signaling by AKT1 E17K in Cancer";"Macroautophagy";"VEGFR2 mediated vascular permeability" XP_046740546.1 4 KEGG: 00513+2.4.1.260;KEGG: 00510+2.4.1.260;Reactome: R-HSA-446193;Reactome: R-HSA-4720489 "Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG12 causes ALG12-CDG (CDG-1g)" XP_046736830.1 15 Reactome: R-HSA-5467340;Reactome: R-HSA-4641262;Reactome: R-HSA-5358751;Reactome: R-HSA-111465;Reactome: R-HSA-195253;Reactome: R-HSA-3769402;Reactome: R-HSA-5467333;Reactome: R-HSA-5689896;Reactome: R-HSA-5339716;Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-5358752;Reactome: R-HSA-5467348 "AXIN missense mutants destabilize the destruction complex";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S45 mutants of beta-catenin aren't phosphorylated";"Apoptotic cleavage of cellular proteins";"Degradation of beta-catenin by the destruction complex";"Deactivation of the beta-catenin transactivating complex";"APC truncation mutants are not K63 polyubiquitinated";"Ovarian tumor domain proteases";"Misspliced GSK3beta mutants stabilize beta-catenin";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex" XP_046739840.1 4 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-5250958;Reactome: R-HSA-6794361 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)";"Neurexins and neuroligins" XP_046736009.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046749712.1 1 Reactome: R-HSA-8850843 "Phosphate bond hydrolysis by NTPDase proteins" XP_046746089.1 1 Reactome: R-HSA-5658442 "Regulation of RAS by GAPs" XP_046752766.1 2 Reactome: R-HSA-5635838;Reactome: R-HSA-5632681 "Activation of SMO";"Ligand-receptor interactions" XP_046748515.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046747098.1 9 Reactome: R-HSA-6782315;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "tRNA modification in the nucleus and cytosol";"Relaxin signaling pathway";"Human papillomavirus infection";"Regulation of TP53 Activity through Phosphorylation";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046753911.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046742262.1 13 Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-975957 "Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046739687.1 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" XP_046752454.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046752850.1 3 MetaCyc: PWY-2161;Reactome: R-HSA-196757;KEGG: 00790+6.3.2.17 "Folate polyglutamylation";"Metabolism of folate and pterines";"Folate biosynthesis" XP_046734775.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046739295.1 7 Reactome: R-HSA-141444;Reactome: R-HSA-5626467;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids" XP_046749383.1 7 Reactome: R-HSA-1660516;Reactome: R-HSA-1660514;Reactome: R-HSA-1660499;MetaCyc: PWY-6352;KEGG: 00562+2.7.1.67;MetaCyc: PWY-6351;KEGG: 04070+2.7.1.67 "Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the plasma membrane";"3-phosphoinositide biosynthesis";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system" XP_046737804.1 2 Reactome: R-HSA-6783310;Reactome: R-HSA-5693568 "Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates" XP_046741406.1 5 Reactome: R-HSA-6807878;Reactome: R-HSA-204005;Reactome: R-HSA-6811434;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"COPII-mediated vesicle transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic" XP_046751622.1 2 Reactome: R-HSA-168276;Reactome: R-HSA-1169408 "NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism" XP_046747453.1 2 KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981 "Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis" XP_046751204.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046737918.1 12 KEGG: 00051+4.1.2.13;MetaCyc: PWY-5484;MetaCyc: PWY-7385;MetaCyc: PWY-1042;MetaCyc: PWY-1861;MetaCyc: PWY-6142;KEGG: 00710+4.1.2.13;Reactome: R-HSA-70263;Reactome: R-HSA-70171;KEGG: 00680+4.1.2.13;KEGG: 00030+4.1.2.13;KEGG: 00010+4.1.2.13 "Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)";"1,3-propanediol biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis";"Glycolysis";"Methane metabolism";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis" XP_046753011.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046740036.1 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" XP_046743338.1 5 KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00380+1.2.4.2;Reactome: R-HSA-389661;MetaCyc: PWY-5084 "Lysine degradation";"Citrate cycle (TCA cycle)";"Tryptophan metabolism";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA" XP_046739679.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046734426.1 2 Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13 "RHO GTPases activate PKNs";"Phosphatidylinositol signaling system" XP_046736840.1 4 MetaCyc: PWY-7204;Reactome: R-HSA-964975;KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282 "Pyridoxal 5'-phosphate salvage II (plants)";"Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis" XP_046742383.1 3 Reactome: R-HSA-8939236;Reactome: R-HSA-383280;Reactome: R-HSA-983231 "RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production" XP_046745475.1 5 KEGG: 04660+3.1.3.16;Reactome: R-HSA-176407;Reactome: R-HSA-5687128;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"MAPK6/MAPK4 signaling";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046735500.1 6 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72163;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046736884.1 3 Reactome: R-HSA-983168;Reactome: R-HSA-390471;Reactome: R-HSA-8951664 "Antigen processing: Ubiquitination & Proteasome degradation";"Association of TriC/CCT with target proteins during biosynthesis";"Neddylation" XP_046742914.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" XP_046743876.1 6 Reactome: R-HSA-3371599;MetaCyc: PWY-6987;KEGG: 00780+6.3.4.15;Reactome: R-HSA-196780;MetaCyc: PWY-7382;KEGG: 00785+2.3.1.181 "Defective HLCS causes multiple carboxylase deficiency";"Lipoate biosynthesis and incorporation III (Bacillus)";"Biotin metabolism";"Biotin transport and metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism" XP_046742672.1 3 Reactome: R-HSA-1483213;MetaCyc: PWY-5669;KEGG: 00564+4.1.1.65 "Synthesis of PE";"Phosphatidylserine and phosphatidylethanolamine biosynthesis I";"Glycerophospholipid metabolism" XP_046751678.1 2 Reactome: R-HSA-203927;Reactome: R-HSA-426486 "MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis" XP_046745941.1 2 Reactome: R-HSA-3928665;Reactome: R-HSA-2682334 "EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling" XP_046735143.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046740205.1 2 Reactome: R-HSA-446205;KEGG: 00500+2.4.1.15 "Synthesis of GDP-mannose";"Starch and sucrose metabolism" XP_046741256.1 11 Reactome: R-HSA-4420332;Reactome: R-HSA-2022928;Reactome: R-HSA-3000170;Reactome: R-HSA-202733;Reactome: R-HSA-975634;Reactome: R-HSA-1971475;Reactome: R-HSA-3656237;Reactome: R-HSA-3560801;Reactome: R-HSA-3560783;Reactome: R-HSA-2024096;Reactome: R-HSA-3656253 "Defective B3GALT6 causes EDSP2 and SEMDJL1";"HS-GAG biosynthesis";"Syndecan interactions";"Cell surface interactions at the vascular wall";"Retinoid metabolism and transport";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective EXT2 causes exostoses 2";"Defective B3GAT3 causes JDSSDHD";"Defective B4GALT7 causes EDS, progeroid type";"HS-GAG degradation";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS" XP_046740069.1 1 MetaCyc: PWY-6308 "L-cysteine biosynthesis II (tRNA-dependent)" XP_046742974.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046749372.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046753904.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046748908.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046738973.1 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" XP_046736124.1 3 KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16 "T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation" XP_046750126.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046753882.1 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" XP_046753069.1 2 Reactome: R-HSA-5693568;Reactome: R-HSA-6783310 "Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway" XP_046744835.1 3 Reactome: R-HSA-450604;Reactome: R-HSA-429947;Reactome: R-HSA-380994 "KSRP (KHSRP) binds and destabilizes mRNA";"Deadenylation of mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress" XP_046735562.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046743683.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046739214.1 1 Reactome: R-HSA-611105 "Respiratory electron transport" XP_046744219.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046749289.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046749809.1 1 Reactome: R-HSA-70350 "Fructose catabolism" XP_046743200.1 8 Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-9639288;Reactome: R-HSA-6798695;Reactome: R-HSA-165159;Reactome: R-HSA-8943724 "Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"Amino acids regulate mTORC1";"Neutrophil degranulation";"mTOR signalling";"Regulation of PTEN gene transcription" XP_046750770.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046747752.1 2 Reactome: R-HSA-380270;Reactome: R-HSA-380320 "Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes" XP_046735243.1 6 Reactome: R-HSA-3000171;Reactome: R-HSA-2022090;Reactome: R-HSA-1650814;Reactome: R-HSA-8948216;Reactome: R-HSA-8874081;Reactome: R-HSA-1442490 "Non-integrin membrane-ECM interactions";"Assembly of collagen fibrils and other multimeric structures";"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization";"MET activates PTK2 signaling";"Collagen degradation" XP_046743085.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046747015.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046739225.1 1 Reactome: R-HSA-8854214 "TBC/RABGAPs" XP_046739790.1 16 Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-9633012 "Translation initiation complex formation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046751993.1 3 Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648 "Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK" XP_046746791.1 19 Reactome: R-HSA-3000484;Reactome: R-HSA-8963888;Reactome: R-HSA-3000480;Reactome: R-HSA-8963901;Reactome: R-HSA-8964046;Reactome: R-HSA-8964038;Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471;Reactome: R-HSA-8964026;Reactome: R-HSA-8964041;Reactome: R-HSA-8957275;Reactome: R-HSA-381426;Reactome: R-HSA-8856828;Reactome: R-HSA-3000497;Reactome: R-HSA-8866423;Reactome: R-HSA-432142;Reactome: R-HSA-8856825 "Scavenging by Class F Receptors";"Chylomicron assembly";"Scavenging by Class A Receptors";"Chylomicron remodeling";"VLDL clearance";"LDL clearance";"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors";"Chylomicron clearance";"LDL remodeling";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Clathrin-mediated endocytosis";"Scavenging by Class H Receptors";"VLDL assembly";"Platelet sensitization by LDL";"Cargo recognition for clathrin-mediated endocytosis" XP_046751202.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046753837.1 20 KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-165159;KEGG: 04150+2.7.11.1;Reactome: R-HSA-166208;KEGG: 05170+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-6804757;Reactome: R-HSA-9639288;Reactome: R-HSA-3371571;Reactome: R-HSA-8943724;Reactome: R-HSA-1257604;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;KEGG: 04151+2.7.11.1;Reactome: R-HSA-1632852;Reactome: R-HSA-5218920;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signalling";"mTOR signaling pathway";"mTORC1-mediated signalling";"Human immunodeficiency virus 1 infection";"CD28 dependent PI3K/Akt signaling";"Regulation of TP53 Degradation";"Amino acids regulate mTORC1";"HSF1-dependent transactivation";"Regulation of PTEN gene transcription";"PIP3 activates AKT signaling";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"PI3K-Akt signaling pathway";"Macroautophagy";"VEGFR2 mediated vascular permeability";"Thermogenesis";"Human cytomegalovirus infection" XP_046754091.1 6 Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6;Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;Reactome: R-HSA-6798695;KEGG: 00380+1.11.1.6 "Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism";"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Neutrophil degranulation";"Tryptophan metabolism" XP_046738799.1 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" XP_046745347.1 10 Reactome: R-HSA-5357905;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5357956;KEGG: 05165+2.7.11.1;KEGG: 04660+2.7.10.2;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Regulation of TNFR1 signaling";"Relaxin signaling pathway";"TNFR1-induced NFkappaB signaling pathway";"Human papillomavirus infection";"T cell receptor signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046753545.1 5 Reactome: R-HSA-5250924;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-427413;Reactome: R-HSA-73772 "B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape" XP_046735151.1 1 Reactome: R-HSA-419771 "Opsins" XP_046738522.1 7 MetaCyc: PWY-5074;KEGG: 00280+4.1.3.4;Reactome: R-HSA-9033241;KEGG: 00650+4.1.3.4;KEGG: 00281+4.1.3.4;KEGG: 00072+4.1.3.4;Reactome: R-HSA-77111 "Mevalonate degradation";"Valine, leucine and isoleucine degradation";"Peroxisomal protein import";"Butanoate metabolism";"Geraniol degradation";"Synthesis and degradation of ketone bodies";"Synthesis of Ketone Bodies" XP_046750608.1 4 MetaCyc: PWY-7494;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-3722;Reactome: R-HSA-6798163 "Choline degradation IV";"Glycine, serine and threonine metabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline catabolism" XP_046752586.1 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" XP_046739743.1 3 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15;Reactome: R-HSA-5628897 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism";"TP53 Regulates Metabolic Genes" XP_046733718.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046748697.1 6 KEGG: 00760+6.3.1.5;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1;Reactome: R-HSA-196807;MetaCyc: PWY-7761;MetaCyc: PWY-5381 "Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD salvage pathway II (PNC IV cycle)";"Pyridine nucleotide cycling (plants)" XP_046735946.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046743271.1 6 MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463 "Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis" XP_046736040.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046743685.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046752256.1 3 KEGG: 00561+3.1.1.23;Reactome: R-HSA-426048;MetaCyc: PWY-7420 "Glycerolipid metabolism";"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)" XP_046742434.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046743143.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046746219.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046742542.1 2 Reactome: R-HSA-1483191;Reactome: R-HSA-425366 "Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds" XP_046751722.1 6 Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72689 "Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits" XP_046752816.1 7 KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046753761.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046742018.1 1 Reactome: R-HSA-426117 "Cation-coupled Chloride cotransporters" XP_046749513.1 4 KEGG: 00232+2.3.1.5;Reactome: R-HSA-156582;KEGG: 00633+2.3.1.5;KEGG: 00983+2.3.1.5 "Caffeine metabolism";"Acetylation";"Nitrotoluene degradation";"Drug metabolism - other enzymes" XP_046744315.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046752042.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046746239.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046746297.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046753748.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046743239.1 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" XP_046743874.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046752791.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046742932.1 6 MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463 "Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis" XP_046739253.1 1 Reactome: R-HSA-1614517 "Sulfide oxidation to sulfate" XP_046747260.1 2 Reactome: R-HSA-8866654;Reactome: R-HSA-9033241 "E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import" XP_046752031.1 5 Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-1222556 "Ion channel transport";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Insulin receptor recycling";"ROS and RNS production in phagocytes" XP_046734621.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046749742.1 9 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-198323;Reactome: R-HSA-5674400;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"AKT phosphorylates targets in the cytosol";"Constitutive Signaling by AKT1 E17K in Cancer";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046734917.1 9 Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-110314;Reactome: R-HSA-8951664;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823 "Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Neddylation";"Dual Incision in GG-NER";"Dual incision in TC-NER";"DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex" XP_046753877.1 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" XP_046745964.1 2 KEGG: 00510+2.4.1.256;Reactome: R-HSA-446193 "N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" XP_046734317.1 16 Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-9018519;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700;Reactome: R-HSA-8934593;Reactome: R-HSA-9029569;Reactome: R-HSA-4086398;Reactome: R-HSA-426496;Reactome: R-HSA-2559585;Reactome: R-HSA-5687128;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459 "Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Estrogen-dependent gene expression";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of RUNX1 Expression and Activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Ca2+ pathway";"Post-transcriptional silencing by small RNAs";"Oncogene Induced Senescence";"MAPK6/MAPK4 signaling";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046734056.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046740760.1 3 Reactome: R-HSA-8868766;Reactome: R-HSA-6784531;Reactome: R-HSA-6785470 "rRNA processing in the mitochondrion";"tRNA processing in the nucleus";"tRNA processing in the mitochondrion" XP_046745233.1 2 Reactome: R-HSA-1482798;Reactome: R-HSA-1268020 "Acyl chain remodeling of CL";"Mitochondrial protein import" XP_046751728.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046749979.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046743990.1 4 Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16 "DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway" XP_046742581.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046745523.1 4 MetaCyc: PWY-8026;Reactome: R-HSA-6807047;KEGG: 00100+1.3.1.72;Reactome: R-HSA-6807062 "Sterol biosynthesis (methylotrophs)";"Cholesterol biosynthesis via desmosterol";"Steroid biosynthesis";"Cholesterol biosynthesis via lathosterol" XP_046745120.1 1 Reactome: R-HSA-429958 "mRNA decay by 3' to 5' exoribonuclease" XP_046738069.1 179 Reactome: R-HSA-2559580;Reactome: R-HSA-69231;Reactome: R-HSA-5655862;Reactome: R-HSA-174048;Reactome: R-HSA-8948751;Reactome: R-HSA-2122947;Reactome: R-HSA-9633012;Reactome: R-HSA-8939902;Reactome: R-HSA-6804757;Reactome: R-HSA-5693565;Reactome: R-HSA-5610783;Reactome: R-HSA-1799339;Reactome: R-HSA-2173795;Reactome: R-HSA-211733;Reactome: R-HSA-174113;Reactome: R-HSA-917729;Reactome: R-HSA-174154;Reactome: R-HSA-6807004;Reactome: R-HSA-4641257;Reactome: R-HSA-912631;Reactome: R-HSA-8876493;Reactome: R-HSA-5675221;Reactome: R-HSA-9013507;Reactome: R-HSA-450321;Reactome: R-HSA-975163;Reactome: R-HSA-450408;Reactome: R-HSA-5357905;Reactome: R-HSA-187577;Reactome: R-HSA-5689896;Reactome: R-HSA-6782135;Reactome: R-HSA-8852276;Reactome: R-HSA-1253288;Reactome: R-HSA-9020702;Reactome: R-HSA-5656169;Reactome: R-HSA-168927;Reactome: R-HSA-180534;Reactome: R-HSA-6782210;Reactome: R-HSA-168638;Reactome: R-HSA-182971;Reactome: R-HSA-2173791;Reactome: R-HSA-2644606;Reactome: R-HSA-8941858;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-5654727;Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-975144;Reactome: R-HSA-5610785;Reactome: R-HSA-349425;Reactome: R-HSA-5205685;Reactome: R-HSA-5607764;Reactome: R-HSA-2408557;Reactome: R-HSA-5687128;Reactome: R-HSA-72706;Reactome: R-HSA-2559585;Reactome: R-HSA-156902;Reactome: R-HSA-532668;Reactome: R-HSA-5684264;Reactome: R-HSA-2691232;Reactome: R-HSA-2173788;Reactome: R-HSA-1236382;Reactome: R-HSA-68949;Reactome: R-HSA-179409;Reactome: R-HSA-5675482;Reactome: R-HSA-2672351;Reactome: R-HSA-9014325;Reactome: R-HSA-4641263;Reactome: R-HSA-983168;Reactome: R-HSA-6781827;Reactome: R-HSA-8866654;Reactome: R-HSA-9645460;Reactome: R-HSA-2173796;Reactome: R-HSA-3769402;Reactome: R-HSA-110312;Reactome: R-HSA-975956;Reactome: R-HSA-400253;Reactome: R-HSA-9637628;Reactome: R-HSA-5656121;Reactome: R-HSA-937041;Reactome: R-HSA-5358346;Reactome: R-HSA-6791226;Reactome: R-HSA-6804756;Reactome: R-HSA-937042;Reactome: R-HSA-75815;Reactome: R-HSA-901032;Reactome: R-HSA-1236974;Reactome: R-HSA-69541;Reactome: R-HSA-2559582;Reactome: R-HSA-209543;Reactome: R-HSA-5689901;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-110314;Reactome: R-HSA-9010553;Reactome: R-HSA-5678895;Reactome: R-HSA-5685942;Reactome: R-HSA-8875360;Reactome: R-HSA-174184;Reactome: R-HSA-175474;Reactome: R-HSA-977225;Reactome: R-HSA-6804760;Reactome: R-HSA-8854050;Reactome: R-HSA-917937;Reactome: R-HSA-5689877;Reactome: R-HSA-936440;Reactome: R-HSA-1358803;Reactome: R-HSA-5696400;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-3322077;Reactome: R-HSA-4641258;Reactome: R-HSA-69601;Reactome: R-HSA-975110;Reactome: R-HSA-5676590;Reactome: R-HSA-8948747;Reactome: R-HSA-2565942;Reactome: R-HSA-174178;Reactome: R-HSA-205043;Reactome: R-HSA-3134975;Reactome: R-HSA-5654733;Reactome: R-HSA-5610780;Reactome: R-HSA-6781823;Reactome: R-HSA-936964;Reactome: R-HSA-5693607;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-9013973;Reactome: R-HSA-6783310;Reactome: R-HSA-9646399;Reactome: R-HSA-937072;Reactome: R-HSA-8856825;Reactome: R-HSA-8849469;Reactome: R-HSA-2122948;Reactome: R-HSA-3785653;Reactome: R-HSA-5654732;Reactome: R-HSA-8856828;Reactome: R-HSA-195253;Reactome: R-HSA-5696394;Reactome: R-HSA-5654726;Reactome: R-HSA-5658442;Reactome: R-HSA-1295596;Reactome: R-HSA-8939236;Reactome: R-HSA-5696397;Reactome: R-HSA-162588;Reactome: R-HSA-382556;Reactome: R-HSA-445989;Reactome: R-HSA-110320;Reactome: R-HSA-937039;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-2979096;Reactome: R-HSA-9033241;Reactome: R-HSA-975957;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5357956;Reactome: R-HSA-69017;Reactome: R-HSA-209560;Reactome: R-HSA-8863795;Reactome: R-HSA-5607761;Reactome: R-HSA-8866652;Reactome: R-HSA-156827;Reactome: R-HSA-1169408;Reactome: R-HSA-201681;Reactome: R-HSA-5362768;Reactome: R-HSA-5696395;Reactome: R-HSA-168928;Reactome: R-HSA-192823;Reactome: R-HSA-9636383;Reactome: R-HSA-450302;Reactome: R-HSA-2894862;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-9613829 "Oxidative Stress Induced Senescence";"Cyclin D associated events in G1";"Translesion synthesis by POLK";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of PTEN stability and activity";"NOTCH1 Intracellular Domain Regulates Transcription";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of RUNX2 expression and activity";"Regulation of TP53 Degradation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Degradation of GLI2 by the proteasome";"SRP-dependent cotranslational protein targeting to membrane";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF-beta-TrCP mediated degradation of Emi1";"Endosomal Sorting Complex Required For Transport (ESCRT)";"APC/C:Cdc20 mediated degradation of Securin";"Negative regulation of MET activity";"Degradation of AXIN";"Regulation of signaling by CBL";"InlA-mediated entry of Listeria monocytogenes into host cells";"Negative regulation of MAPK pathway";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of TNFR1 signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Ovarian tumor domain proteases";"Dual incision in TC-NER";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Downregulation of ERBB4 signaling";"Interleukin-1 signaling";"Termination of translesion DNA synthesis";"TICAM1, RIP1-mediated IKK complex recruitment";"Vpu mediated degradation of CD4";"Gap-filling DNA repair synthesis and ligation in TC-NER";"NOD1/2 Signaling Pathway";"EGFR downregulation";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of RUNX3 expression and activity";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Negative regulation of FGFR2 signaling";"Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"GLI3 is processed to GLI3R by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Pink/Parkin Mediated Mitophagy";"CLEC7A (Dectin-1) signaling";"Selenocysteine synthesis";"MAPK6/MAPK4 signaling";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Oncogene Induced Senescence";"Peptide chain elongation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Downregulation of TGF-beta receptor signaling";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Orc1 removal from chromatin";"APC-Cdc20 mediated degradation of Nek2A";"Regulation of necroptotic cell death";"Stimuli-sensing channels";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Regulation of FZD by ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"E3 ubiquitin ligases ubiquitinate target proteins";"Alpha-protein kinase 1 signaling pathway";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Deactivation of the beta-catenin transactivating complex";"Translesion synthesis by REV1";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Circadian Clock";"Modulation by Mtb of host immune system";"Translesion synthesis by POLI";"IKK complex recruitment mediated by RIP1";"Hedgehog ligand biogenesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Regulation of TP53 Activity through Phosphorylation";"IRAK2 mediated activation of TAK1 complex";"Ubiquitin-dependent degradation of Cyclin D";"ER Quality Control Compartment (ERQC)";"ER-Phagosome pathway";"Stabilization of p53";"Senescence-Associated Secretory Phenotype (SASP)";"p75NTR recruits signalling complexes";"Metalloprotease DUBs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Recognition of DNA damage by PCNA-containing replication complex";"Regulation of expression of SLITs and ROBOs";"Defective CFTR causes cystic fibrosis";"HDR through Homologous Recombination (HRR)";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Assembly Of The HIV Virion";"Amyloid fiber formation";"Regulation of TP53 Activity through Methylation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Iron uptake and transport";"Josephin domain DUBs";"Negative regulators of DDX58/IFIH1 signaling";"Downregulation of ERBB2:ERBB3 signaling";"Dual Incision in GG-NER";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Glycogen synthesis";"Degradation of DVL";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"NIK-->noncanonical NF-kB signaling";"Regulation of PTEN localization";"Regulation of PLK1 Activity at G2/M Transition";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"NRIF signals cell death from the nucleus";"Regulation of innate immune responses to cytosolic DNA";"Negative regulation of FGFR4 signaling";"Degradation of GLI1 by the proteasome";"Formation of TC-NER Pre-Incision Complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Processing of DNA double-strand break ends";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"TICAM1-dependent activation of IRF3/IRF7";"Fanconi Anemia Pathway";"Aggrephagy";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Cargo recognition for clathrin-mediated endocytosis";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"Activated NOTCH1 Transmits Signal to the Nucleus";"Myoclonic epilepsy of Lafora";"Negative regulation of FGFR3 signaling";"Clathrin-mediated endocytosis";"Degradation of beta-catenin by the destruction complex";"DNA Damage Recognition in GG-NER";"Negative regulation of FGFR1 signaling";"Regulation of RAS by GAPs";"Spry regulation of FGF signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Budding and maturation of HIV virion";"ABC-family proteins mediated transport";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Translesion Synthesis by POLH";"IRAK1 recruits IKK complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Peroxisomal protein import";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"TNFR1-induced NFkappaB signaling pathway";"CDK-mediated phosphorylation and removal of Cdc6";"NF-kB is activated and signals survival";"Downregulation of ERBB2 signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"L13a-mediated translational silencing of Ceruloplasmin expression";"ISG15 antiviral mechanism";"TCF dependent signaling in response to WNT";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Formation of Incision Complex in GG-NER";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Viral mRNA Translation";"Prevention of phagosomal-lysosomal fusion";"activated TAK1 mediates p38 MAPK activation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"UCH proteinases";"Asymmetric localization of PCP proteins";"Chaperone Mediated Autophagy" XP_046737288.1 12 Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-9609690 "EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"HCMV Early Events" XP_046745412.1 3 Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648 "Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK" XP_046743847.1 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046734249.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046736483.1 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" XP_046737842.1 2 KEGG: 04150+2.7.11.24;Reactome: R-HSA-5687128 "mTOR signaling pathway";"MAPK6/MAPK4 signaling" XP_046739581.1 1 Reactome: R-HSA-382556 "ABC-family proteins mediated transport" XP_046740747.1 8 KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;MetaCyc: PWY-7922;Reactome: R-HSA-5173105;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5083629 "Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"O-linked glycosylation";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2" XP_046735584.1 27 Reactome: R-HSA-191859;Reactome: R-HSA-159227;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-168271;Reactome: R-HSA-168276;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-5619107;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-159230;Reactome: R-HSA-1169408 "snRNP Assembly";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"HCMV Late Events";"SUMOylation of DNA replication proteins";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"NS1 Mediated Effects on Host Pathways";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism" XP_046734042.1 6 Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-72702 "Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition" XP_046738730.1 6 Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;MetaCyc: PWY-7511 "Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Protein ubiquitination" XP_046750661.1 4 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-77595;Reactome: R-HSA-72163 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway" XP_046734397.1 1 Reactome: R-HSA-9616222 "Transcriptional regulation of granulopoiesis" XP_046751714.1 8 Reactome: R-HSA-212300;Reactome: R-HSA-2559580;Reactome: R-HSA-8943724;Reactome: R-HSA-5617472;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-3214841;Reactome: R-HSA-8953750 "PRC2 methylates histones and DNA";"Oxidative Stress Induced Senescence";"Regulation of PTEN gene transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"PKMTs methylate histone lysines";"Transcriptional Regulation by E2F6" XP_046741036.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046748437.1 14 MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7725;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6598 "Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis" XP_046746270.1 3 Reactome: R-HSA-189451;MetaCyc: PWY-7159;KEGG: 00860+1.3.3.3 "Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism" XP_046743357.1 1 Reactome: R-HSA-69231 "Cyclin D associated events in G1" XP_046744386.1 12 Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399 "COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy" XP_046740495.1 4 KEGG: 00190+3.6.1.1;Reactome: R-HSA-71737;MetaCyc: PWY-7807;MetaCyc: PWY-7805 "Oxidative phosphorylation";"Pyrophosphate hydrolysis";"Glyphosate degradation III";"(aminomethyl)phosphonate degradation" XP_046750693.1 4 KEGG: 00592+3.1.1.32;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.32 "alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Glycerophospholipid metabolism" XP_046740701.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046752452.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046752964.1 1 Reactome: R-HSA-112126 "ALKBH3 mediated reversal of alkylation damage" XP_046750443.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" XP_046753799.1 17 Reactome: R-HSA-5689880;Reactome: R-HSA-9645460;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-202424;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-9020702;Reactome: R-HSA-5607764;Reactome: R-HSA-168638;Reactome: R-HSA-450302;Reactome: R-HSA-4086398;Reactome: R-HSA-937042;Reactome: R-HSA-9014325;Reactome: R-HSA-450321;Reactome: R-HSA-975163;Reactome: R-HSA-445989 "Ub-specific processing proteases";"Alpha-protein kinase 1 signaling pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"Downstream TCR signaling";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Interleukin-1 signaling";"CLEC7A (Dectin-1) signaling";"NOD1/2 Signaling Pathway";"activated TAK1 mediates p38 MAPK activation";"Ca2+ pathway";"IRAK2 mediated activation of TAK1 complex";"TICAM1,TRAF6-dependent induction of TAK1 complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex" XP_046746332.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046751959.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046734928.1 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" XP_046750730.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046737336.1 1 Reactome: R-HSA-71288 "Creatine metabolism" XP_046739791.1 16 Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956 "Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" XP_046736611.1 15 MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-6901;MetaCyc: PWY-6142;KEGG: 00010+2.7.1.40;MetaCyc: PWY-2221;MetaCyc: PWY-6886;MetaCyc: PWY-7003;Reactome: R-HSA-70171;MetaCyc: PWY-7383;MetaCyc: PWY-7218;MetaCyc: PWY-5723;MetaCyc: PWY-8004;KEGG: 00230+2.7.1.40;KEGG: 00620+2.7.1.40 "Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)";"Glycerol degradation to butanol";"Glycolysis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Rubisco shunt";"Entner-Doudoroff pathway I";"Purine metabolism";"Pyruvate metabolism" XP_046740843.1 4 Reactome: R-HSA-381771;Reactome: R-HSA-400511;Reactome: R-HSA-422085;Reactome: R-HSA-1799339 "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin";"SRP-dependent cotranslational protein targeting to membrane" XP_046741614.1 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" XP_046747602.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046752595.1 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" XP_046744400.1 1 Reactome: R-HSA-6787450 "tRNA modification in the mitochondrion" XP_046735052.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046749375.1 1 Reactome: R-HSA-8854691 "Interleukin-20 family signaling" XP_046748906.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046744816.1 5 Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-6804758;Reactome: R-HSA-8943724 "RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation";"Regulation of PTEN gene transcription" XP_046749793.1 6 Reactome: R-HSA-5651801;Reactome: R-HSA-110357;Reactome: R-HSA-73930;Reactome: R-HSA-110373;Reactome: R-HSA-110362;Reactome: R-HSA-73933 "PCNA-Dependent Long Patch Base Excision Repair";"Displacement of DNA glycosylase by APEX1";"Abasic sugar-phosphate removal via the single-nucleotide replacement pathway";"Resolution of AP sites via the multiple-nucleotide patch replacement pathway";"POLB-Dependent Long Patch Base Excision Repair";"Resolution of Abasic Sites (AP sites)" XP_046746938.1 7 KEGG: 00620+1.2.4.1;Reactome: R-HSA-5362517;Reactome: R-HSA-204174;KEGG: 00020+1.2.4.1;KEGG: 00010+1.2.4.1;Reactome: R-HSA-389661;Reactome: R-HSA-70268 "Pyruvate metabolism";"Signaling by Retinoic Acid";"Regulation of pyruvate dehydrogenase (PDH) complex";"Citrate cycle (TCA cycle)";"Glycolysis / Gluconeogenesis";"Glyoxylate metabolism and glycine degradation";"Pyruvate metabolism" XP_046734865.1 2 Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24 "Lysosomal oligosaccharide catabolism";"Other glycan degradation" XP_046735763.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046750925.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046742153.1 14 MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-5972 "Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)" XP_046737299.1 1 Reactome: R-HSA-9033241 "Peroxisomal protein import" XP_046753974.1 9 Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-2151201;Reactome: R-HSA-1368108;Reactome: R-HSA-400206;Reactome: R-HSA-1989781;Reactome: R-HSA-5617472;Reactome: R-HSA-2426168 "Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"RORA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Activation of gene expression by SREBF (SREBP)" XP_046752129.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046744811.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046750663.1 4 Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-3214815 "Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones" XP_046741249.1 4 Reactome: R-HSA-352230;Reactome: R-HSA-210991;Reactome: R-HSA-71240;Reactome: R-HSA-5660862 "Amino acid transport across the plasma membrane";"Basigin interactions";"Tryptophan catabolism";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)" XP_046744812.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046738327.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046751800.1 2 Reactome: R-HSA-400253;Reactome: R-HSA-2151201 "Circadian Clock";"Transcriptional activation of mitochondrial biogenesis" XP_046750387.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046743690.1 19 Reactome: R-HSA-182971;Reactome: R-HSA-194840;Reactome: R-HSA-8964616;Reactome: R-HSA-114604;Reactome: R-HSA-5625970;Reactome: R-HSA-5687128;Reactome: R-HSA-5663213;Reactome: R-HSA-5627123;Reactome: R-HSA-389359;Reactome: R-HSA-5626467;Reactome: R-HSA-428543;Reactome: R-HSA-5663220;Reactome: R-HSA-983231;Reactome: R-HSA-4420097;Reactome: R-HSA-418885;Reactome: R-HSA-3928662;Reactome: R-HSA-2029482;Reactome: R-HSA-8950505;Reactome: R-HSA-525793 "EGFR downregulation";"Rho GTPase cycle";"G beta:gamma signalling through CDC42";"GPVI-mediated activation cascade";"RHO GTPases activate KTN1";"MAPK6/MAPK4 signaling";"RHO GTPases Activate WASPs and WAVEs";"RHO GTPases activate PAKs";"CD28 dependent Vav1 pathway";"RHO GTPases activate IQGAPs";"Inactivation of CDC42 and RAC1";"RHO GTPases Activate Formins";"Factors involved in megakaryocyte development and platelet production";"VEGFA-VEGFR2 Pathway";"DCC mediated attractive signaling";"EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Myogenesis" XP_046739881.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046743016.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-6783310 "Protein ubiquitination";"Fanconi Anemia Pathway" XP_046753906.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046745206.1 3 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046743901.1 1 Reactome: R-HSA-5663220 "RHO GTPases Activate Formins" XP_046747206.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" XP_046750642.1 6 Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68949 "Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Orc1 removal from chromatin" XP_046734315.1 16 Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459;Reactome: R-HSA-4086398;Reactome: R-HSA-5687128;Reactome: R-HSA-2559585;Reactome: R-HSA-426496;Reactome: R-HSA-8934593;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700 "Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Ca2+ pathway";"MAPK6/MAPK4 signaling";"Oncogene Induced Senescence";"Post-transcriptional silencing by small RNAs";"Regulation of RUNX1 Expression and Activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation" XP_046746224.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046736719.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046740002.1 6 MetaCyc: PWY-6123;MetaCyc: PWY-7234;MetaCyc: PWY-6124;KEGG: 00230+6.3.2.6;KEGG: 00230+4.1.1.21;Reactome: R-HSA-73817 "Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis II";"Purine metabolism";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis" XP_046735842.1 4 MetaCyc: PWY-7204;Reactome: R-HSA-964975;KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282 "Pyridoxal 5'-phosphate salvage II (plants)";"Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis" XP_046752128.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046737835.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046744962.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046750487.1 3 Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508 "G alpha (z) signalling events";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis" XP_046751541.1 1 MetaCyc: PWY-7437 "Protein O-[N-acetyl]-glucosylation" XP_046752519.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046753304.1 1 Reactome: R-HSA-2428928 "IRS-related events triggered by IGF1R" XP_046745772.1 4 KEGG: 00564+3.1.1.32;KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803 "Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing" XP_046752341.1 3 KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046736088.1 6 Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72706 "Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046751018.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046736189.1 2 KEGG: 00514+2.4.1.221;Reactome: R-HSA-1912399 "Other types of O-glycan biosynthesis";"Pre-NOTCH Processing in the Endoplasmic Reticulum" XP_046749400.1 4 Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-3769402 "Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex" XP_046747241.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046749899.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046751729.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046747488.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046738734.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046744129.1 1 Reactome: R-HSA-191859 "snRNP Assembly" XP_046737309.1 14 MetaCyc: PWY-7782;KEGG: 00565+3.1.3.4;MetaCyc: PWY-8053;MetaCyc: PWY-8055;Reactome: R-HSA-1483213;Reactome: R-HSA-4419969;KEGG: 00564+3.1.3.4;KEGG: 00600+3.1.3.4;MetaCyc: PWY-6453;MetaCyc: PWY-8052;MetaCyc: PWY-8051;Reactome: R-HSA-75109;Reactome: R-HSA-1483191;KEGG: 00561+3.1.3.4 "Plasmalogen biosynthesis";"Ether lipid metabolism";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Synthesis of PE";"Depolymerisation of the Nuclear Lamina";"Glycerophospholipid metabolism";"Sphingolipid metabolism";"Stigma estolide biosynthesis";"2-arachidonoylglycerol biosynthesis";"Anandamide biosynthesis I";"Triglyceride biosynthesis";"Synthesis of PC";"Glycerolipid metabolism" XP_046746233.1 3 Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.20 "Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046753548.1 8 Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-182218;Reactome: R-HSA-167590;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-9636467;Reactome: R-HSA-983712 "Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Nef Mediated CD8 Down-regulation";"Nef Mediated CD4 Down-regulation";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Blockage of phagosome acidification";"Ion channel transport" XP_046747946.1 7 Reactome: R-HSA-6814122;Reactome: R-HSA-5620922;Reactome: R-HSA-389957;Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-6798695;Reactome: R-HSA-390450 "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"BBSome-mediated cargo-targeting to cilium";"Prefoldin mediated transfer of substrate to CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Neutrophil degranulation";"Folding of actin by CCT/TriC" XP_046735458.1 1 Reactome: R-HSA-212300 "PRC2 methylates histones and DNA" XP_046753971.1 9 Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-1368082;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-2426168;Reactome: R-HSA-5617472;Reactome: R-HSA-1989781;Reactome: R-HSA-400206 "BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"RORA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"Activation of gene expression by SREBF (SREBP)";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PPARA activates gene expression";"Regulation of lipid metabolism by PPARalpha" XP_046748601.1 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" XP_046749804.1 39 Reactome: R-HSA-190371;Reactome: R-HSA-5654699;Reactome: R-HSA-5654712;Reactome: R-HSA-5654228;Reactome: R-HSA-5654221;Reactome: R-HSA-2033514;Reactome: R-HSA-5654687;Reactome: R-HSA-5658623;Reactome: R-HSA-1257604;Reactome: R-HSA-5654700;Reactome: R-HSA-5654689;Reactome: R-HSA-5654695;Reactome: R-HSA-5654710;Reactome: R-HSA-5654733;Reactome: R-HSA-190375;Reactome: R-HSA-5654704;Reactome: R-HSA-5654706;Reactome: R-HSA-5654227;Reactome: R-HSA-6811558;Reactome: R-HSA-5673001;Reactome: R-HSA-1839130;Reactome: R-HSA-109704;Reactome: R-HSA-5654720;Reactome: R-HSA-2219530;Reactome: R-HSA-5654688;Reactome: R-HSA-2033519;Reactome: R-HSA-5655253;Reactome: R-HSA-5654219;Reactome: R-HSA-1839122;Reactome: R-HSA-5654726;Reactome: R-HSA-5654693;Reactome: R-HSA-190373;Reactome: R-HSA-5654719;Reactome: R-HSA-5654732;Reactome: R-HSA-5654727;Reactome: R-HSA-190322;Reactome: R-HSA-8853338;Reactome: R-HSA-5655302;Reactome: R-HSA-190372 "FGFR3b ligand binding and activation";"SHC-mediated cascade:FGFR2";"FRS-mediated FGFR4 signaling";"Phospholipase C-mediated cascade, FGFR4";"Phospholipase C-mediated cascade, FGFR2";"FGFR3 mutant receptor activation";"Downstream signaling of activated FGFR1";"FGFRL1 modulation of FGFR1 signaling";"PIP3 activates AKT signaling";"FRS-mediated FGFR2 signaling";"PI-3K cascade:FGFR1";"PI-3K cascade:FGFR2";"PI-3K cascade:FGFR3";"Negative regulation of FGFR4 signaling";"FGFR2c ligand binding and activation";"SHC-mediated cascade:FGFR3";"FRS-mediated FGFR3 signaling";"Phospholipase C-mediated cascade, FGFR3";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RAF/MAP kinase cascade";"Signaling by activated point mutants of FGFR3";"PI3K Cascade";"PI-3K cascade:FGFR4";"Constitutive Signaling by Aberrant PI3K in Cancer";"SHC-mediated cascade:FGFR1";"Activated point mutants of FGFR2";"Signaling by FGFR2 in disease";"Phospholipase C-mediated cascade: FGFR1";"Signaling by activated point mutants of FGFR1";"Negative regulation of FGFR1 signaling";"FRS-mediated FGFR1 signaling";"FGFR1c ligand binding and activation";"SHC-mediated cascade:FGFR4";"Negative regulation of FGFR3 signaling";"Negative regulation of FGFR2 signaling";"FGFR4 ligand binding and activation";"Signaling by FGFR3 point mutants in cancer";"Signaling by FGFR1 in disease";"FGFR3c ligand binding and activation" XP_046744399.1 1 Reactome: R-HSA-6787450 "tRNA modification in the mitochondrion" XP_046745703.1 2 Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7 "Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis" XP_046745196.1 3 Reactome: R-HSA-8854691;Reactome: R-HSA-6785807;KEGG: 04660+2.7.10.2 "Interleukin-20 family signaling";"Interleukin-4 and Interleukin-13 signaling";"T cell receptor signaling pathway" XP_046737831.1 8 Reactome: R-HSA-68689;Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68962;Reactome: R-HSA-68616;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68949 "CDC6 association with the ORC:origin complex";"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin" XP_046746666.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046747596.1 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" XP_046753006.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046749543.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046753263.1 4 KEGG: 00534+2.4.2.26;KEGG: 00532+2.4.2.26;Reactome: R-HSA-1971475;MetaCyc: PWY-6557 "Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate";"A tetrasaccharide linker sequence is required for GAG synthesis";"Glycosaminoglycan-protein linkage region biosynthesis" XP_046751969.1 2 Reactome: R-HSA-2672351;Reactome: R-HSA-5578775 "Stimuli-sensing channels";"Ion homeostasis" XP_046750920.1 3 KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596;Reactome: R-HSA-74217 "Purine metabolism";"Adenosine nucleotides degradation I";"Purine salvage" XP_046734777.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046739698.1 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" XP_046736320.1 3 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing" XP_046753420.1 5 KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7269 "Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)" XP_046735657.1 9 Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-6807505;Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-167162 "RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape" XP_046739034.1 3 Reactome: R-HSA-2299718;Reactome: R-HSA-3214841;Reactome: R-HSA-6804760 "Condensation of Prophase Chromosomes";"PKMTs methylate histone lysines";"Regulation of TP53 Activity through Methylation" XP_046741586.1 14 MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-7725;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199 "(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation" XP_046744959.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046738527.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-1989781 "Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression" XP_046753277.1 2 Reactome: R-HSA-8949664;Reactome: R-HSA-8949215 "Processing of SMDT1";"Mitochondrial calcium ion transport" XP_046739998.1 7 MetaCyc: PWY-6121;Reactome: R-HSA-73817;MetaCyc: PWY-7282;MetaCyc: PWY-6122;KEGG: 00250+2.4.2.14;MetaCyc: PWY-6277;KEGG: 00230+2.4.2.14 "5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Alanine, aspartate and glutamate metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine metabolism" XP_046739354.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046747257.1 2 Reactome: R-HSA-1632852;Reactome: R-HSA-1660499 "Macroautophagy";"Synthesis of PIPs at the plasma membrane" XP_046741480.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046737359.1 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" XP_046753824.1 14 Reactome: R-HSA-5685942;Reactome: R-HSA-110320;Reactome: R-HSA-110312;Reactome: R-HSA-110314;Reactome: R-HSA-5656169;Reactome: R-HSA-5656121;Reactome: R-HSA-69091;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-5655862;Reactome: R-HSA-5696397;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-6782210 "HDR through Homologous Recombination (HRR)";"Translesion Synthesis by POLH";"Translesion synthesis by REV1";"Recognition of DNA damage by PCNA-containing replication complex";"Termination of translesion DNA synthesis";"Translesion synthesis by POLI";"Polymerase switching";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Gap-filling DNA repair synthesis and ligation in TC-NER" XP_046742945.1 2 Reactome: R-HSA-1268020;Reactome: R-HSA-8949664 "Mitochondrial protein import";"Processing of SMDT1" XP_046750647.1 6 MetaCyc: PWY-5668;Reactome: R-HSA-1483148;Reactome: R-HSA-1483166;KEGG: 00564+2.7.8.5;MetaCyc: PWY-5269;MetaCyc: PWY-7817 "Cardiolipin biosynthesis I";"Synthesis of PG";"Synthesis of PA";"Glycerophospholipid metabolism";"Cardiolipin biosynthesis II";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046746099.1 10 MetaCyc: PWY-6362;Reactome: R-HSA-1855191;KEGG: 00562+2.7.1.158;KEGG: 04070+2.7.1.158;MetaCyc: PWY-6369;MetaCyc: PWY-6554;MetaCyc: PWY-6361;MetaCyc: PWY-4661;Reactome: R-HSA-1855167;MetaCyc: PWY-6372 "1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Synthesis of IPs in the nucleus";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)" XP_046751689.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046739230.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046740587.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046737117.1 2 Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2 "Signaling by SCF-KIT";"T cell receptor signaling pathway" XP_046748965.1 1 Reactome: R-HSA-5635838 "Activation of SMO" XP_046749861.1 1 Reactome: R-HSA-1296052 "Ca2+ activated K+ channels" XP_046753999.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046733975.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046747817.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046746628.1 16 Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957 "Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Peptide chain elongation";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046742491.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046753425.1 5 Reactome: R-HSA-196807;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;MetaCyc: PWY-5083 "Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation" XP_046743832.1 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" XP_046745442.1 15 Reactome: R-HSA-114604;Reactome: R-HSA-1257604;Reactome: R-HSA-1266695;Reactome: R-HSA-8853659;Reactome: R-HSA-416476;Reactome: R-HSA-6811558;Reactome: R-HSA-9009391;Reactome: R-HSA-912631;Reactome: R-HSA-1433557;Reactome: R-HSA-389357;Reactome: R-HSA-388841;Reactome: R-HSA-912526;Reactome: R-HSA-2219530;Reactome: R-HSA-1660499;Reactome: R-HSA-512988 "GPVI-mediated activation cascade";"PIP3 activates AKT signaling";"Interleukin-7 signaling";"RET signaling";"G alpha (q) signalling events";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Extra-nuclear estrogen signaling";"Regulation of signaling by CBL";"Signaling by SCF-KIT";"CD28 dependent PI3K/Akt signaling";"Costimulation by the CD28 family";"Interleukin receptor SHC signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Synthesis of PIPs at the plasma membrane";"Interleukin-3, Interleukin-5 and GM-CSF signaling" XP_046752710.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046748086.1 4 KEGG: 00230+4.1.1.97;MetaCyc: PWY-5691;MetaCyc: PWY-7849;MetaCyc: PWY-7394 "Purine metabolism";"Urate conversion to allantoin I";"Urate conversion to allantoin III";"Urate conversion to allantoin II" XP_046752212.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046744175.1 7 KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046751101.1 7 Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-76066 "RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" XP_046752369.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046752446.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046749137.1 7 Reactome: R-HSA-156711;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-1362300 "Polo-like kinase mediated events";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" XP_046753858.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046735018.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046735146.1 14 MetaCyc: PWY-561;KEGG: 00020+1.3.5.1;MetaCyc: PWY-5690;MetaCyc: PWY-7279;MetaCyc: PWY-4302;KEGG: 00720+1.3.5.1;MetaCyc: PWY-3781;Reactome: R-HSA-611105;MetaCyc: PWY-6728;KEGG: 00650+1.3.5.1;MetaCyc: PWY-6969;Reactome: R-HSA-71403;MetaCyc: PWY-7254;KEGG: 00190+1.3.5.1 "Superpathway of glyoxylate cycle and fatty acid degradation";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration III (alternative oxidase pathway)";"Carbon fixation pathways in prokaryotes";"Aerobic respiration I (cytochrome c)";"Respiratory electron transport";"Methylaspartate cycle";"Butanoate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citric acid cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Oxidative phosphorylation" XP_046740570.1 4 Reactome: R-HSA-446193;KEGG: 00513+2.4.1.257+2.4.1.132;Reactome: R-HSA-4549349;KEGG: 00510+2.4.1.257+2.4.1.132 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"Defective ALG2 causes ALG2-CDG (CDG-1i)";"N-Glycan biosynthesis" XP_046741479.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046736578.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046736324.1 2 Reactome: R-HSA-1483148;Reactome: R-HSA-1483166 "Synthesis of PG";"Synthesis of PA" XP_046741400.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782 "Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis" XP_046751694.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046752238.1 12 MetaCyc: PWY-5872;MetaCyc: PWY-5871;MetaCyc: PWY-5857;MetaCyc: PWY-7233;MetaCyc: PWY-5855;MetaCyc: PWY-5856;Reactome: R-HSA-2142789;MetaCyc: PWY-7230;MetaCyc: PWY-6708;MetaCyc: PWY-5870;KEGG: 00130+1.14.99.60;MetaCyc: PWY-5873 "Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-7 biosynthesis (eukaryotic)" XP_046751487.1 5 Reactome: R-HSA-5663213;Reactome: R-HSA-3928662;Reactome: R-HSA-6798695;Reactome: R-HSA-8856828;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling";"Neutrophil degranulation";"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation" XP_046740379.1 5 Reactome: R-HSA-199220;MetaCyc: PWY-6012-1;KEGG: 00770+2.7.8.7;MetaCyc: PWY-6012;MetaCyc: PWY-6289 "Vitamin B5 (pantothenate) metabolism";"Acyl carrier protein activation";"Pantothenate and CoA biosynthesis";"Acyl carrier protein metabolism";"Petrobactin biosynthesis" XP_046751738.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046748747.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046735834.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046743269.1 6 MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463 "Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis" XP_046735582.1 3 Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-375276 "G alpha (i) signalling events";"G alpha (q) signalling events";"Peptide ligand-binding receptors" XP_046753840.1 7 Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380284 "Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome" XP_046747184.1 5 Reactome: R-HSA-1989781;Reactome: R-HSA-211976;Reactome: R-HSA-211981;Reactome: R-HSA-211945;Reactome: R-HSA-8937144 "PPARA activates gene expression";"Endogenous sterols";"Xenobiotics";"Phase I - Functionalization of compounds";"Aryl hydrocarbon receptor signalling" XP_046751544.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046734717.1 2 Reactome: R-HSA-446199;KEGG: 00510+3.6.1.43 "Synthesis of Dolichyl-phosphate";"N-Glycan biosynthesis" XP_046745853.1 4 MetaCyc: PWY-7250;KEGG: 00730+2.8.1.7;Reactome: R-HSA-947581;Reactome: R-HSA-1362409 "[2Fe-2S] iron-sulfur cluster biosynthesis";"Thiamine metabolism";"Molybdenum cofactor biosynthesis";"Mitochondrial iron-sulfur cluster biogenesis" XP_046743893.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046742800.1 3 KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16 "PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway" XP_046736475.1 2 Reactome: R-HSA-427413;Reactome: R-HSA-3214847 "NoRC negatively regulates rRNA expression";"HATs acetylate histones" XP_046752621.1 3 MetaCyc: PWY-7999;KEGG: 00130+4.1.1.90;Reactome: R-HSA-159740 "Vitamin K-epoxide cycle";"Ubiquinone and other terpenoid-quinone biosynthesis";"Gamma-carboxylation of protein precursors" XP_046742432.1 2 Reactome: R-HSA-8936459;Reactome: R-HSA-3214841 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines" XP_046742733.1 1 Reactome: R-HSA-606279 "Deposition of new CENPA-containing nucleosomes at the centromere" XP_046744749.1 3 Reactome: R-HSA-8951664;MetaCyc: PWY-7511;Reactome: R-HSA-349425 "Neddylation";"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1" XP_046741019.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046742749.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046734757.1 1 Reactome: R-HSA-2173788 "Downregulation of TGF-beta receptor signaling" XP_046751735.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046743606.1 3 MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3 "D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis";"Galactose metabolism" XP_046750188.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046738557.1 2 Reactome: R-HSA-804914;Reactome: R-HSA-9029569 "Transport of fatty acids";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" XP_046752904.1 5 KEGG: 00740+2.7.1.26;MetaCyc: PWY-6168;MetaCyc: PWY-5523;Reactome: R-HSA-196843;MetaCyc: PWY-7863 "Riboflavin metabolism";"Flavin biosynthesis III (fungi)";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Vitamin B2 (riboflavin) metabolism";"Roseoflavin biosynthesis" XP_046753034.1 3 Reactome: R-HSA-500753;KEGG: 00240+1.3.5.2;MetaCyc: PWY-5686 "Pyrimidine biosynthesis";"Pyrimidine metabolism";"UMP biosynthesis I" XP_046741170.1 1 KEGG: 00970+6.1.1.3 "Aminoacyl-tRNA biosynthesis" XP_046741789.1 8 MetaCyc: PWY-7115;MetaCyc: PWY-5789;MetaCyc: PWY-241;MetaCyc: PWY-6142;MetaCyc: PWY-5744;MetaCyc: PWY-5743;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7117 "C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glyoxylate assimilation";"3-hydroxypropanoate cycle";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type" XP_046742047.1 6 MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-7656;Reactome: R-HSA-9640463 "Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis" XP_046741819.1 3 MetaCyc: PWY-7511;Reactome: R-HSA-110314;Reactome: R-HSA-8866654 "Protein ubiquitination";"Recognition of DNA damage by PCNA-containing replication complex";"E3 ubiquitin ligases ubiquitinate target proteins" XP_046747711.1 3 Reactome: R-HSA-202427;Reactome: R-HSA-6807004;Reactome: R-HSA-6798695 "Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity";"Neutrophil degranulation" XP_046754096.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046734538.1 2 KEGG: 00071+2.3.1.21;MetaCyc: PWY-6111 "Fatty acid degradation";"Mitochondrial L-carnitine shuttle" XP_046743083.1 1 Reactome: R-HSA-3108214 "SUMOylation of DNA damage response and repair proteins" XP_046748954.1 7 Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912 "Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane" XP_046753608.1 10 Reactome: R-HSA-3299685;Reactome: R-HSA-111457;Reactome: R-HSA-9627069;Reactome: R-HSA-611105;Reactome: R-HSA-111458;Reactome: R-HSA-111464;Reactome: R-HSA-111463;Reactome: R-HSA-5628897;Reactome: R-HSA-111459;Reactome: R-HSA-2151201 "Detoxification of Reactive Oxygen Species";"Release of apoptotic factors from the mitochondria";"Regulation of the apoptosome activity";"Respiratory electron transport";"Formation of apoptosome";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"SMAC (DIABLO) binds to IAPs";"TP53 Regulates Metabolic Genes";"Activation of caspases through apoptosome-mediated cleavage";"Transcriptional activation of mitochondrial biogenesis" XP_046746931.1 29 Reactome: R-HSA-73772;Reactome: R-HSA-167162;Reactome: R-HSA-112382;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-167246;Reactome: R-HSA-76042;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-6781827;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-427413;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-113418;Reactome: R-HSA-5696400;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-167161;Reactome: R-HSA-6782210;Reactome: R-HSA-72086;Reactome: R-HSA-167200;Reactome: R-HSA-75955 "RNA Polymerase I Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"Formation of RNA Pol II elongation complex";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of the Early Elongation Complex";"Dual Incision in GG-NER";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"HIV Transcription Initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Capping";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation" XP_046741035.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046734456.1 3 Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286 "Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation" XP_046736180.1 8 KEGG: 05163+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Signaling by Hippo";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046741122.1 1 Reactome: R-HSA-191273 "Cholesterol biosynthesis" XP_046751031.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046739835.1 4 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-5250958;Reactome: R-HSA-6794361 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)";"Neurexins and neuroligins" XP_046742348.1 24 Reactome: R-HSA-416482;Reactome: R-HSA-432040;Reactome: R-HSA-418217;Reactome: R-HSA-392451;Reactome: R-HSA-9009391;Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-381676;Reactome: R-HSA-418555;Reactome: R-HSA-400042;Reactome: R-HSA-456926;Reactome: R-HSA-163359;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-392851;Reactome: R-HSA-420092;Reactome: R-HSA-6814122;Reactome: R-HSA-392170;Reactome: R-HSA-428930;Reactome: R-HSA-8964616;Reactome: R-HSA-4086398;Reactome: R-HSA-500657;Reactome: R-HSA-8964315;Reactome: R-HSA-418592 "G alpha (12/13) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through PLC beta";"G beta:gamma signalling through PI3Kgamma";"Extra-nuclear estrogen signaling";"G alpha (z) signalling events";"G alpha (q) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G alpha (s) signalling events";"Adrenaline,noradrenaline inhibits insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"Glucagon signaling in metabolic regulation";"G alpha (i) signalling events";"G-protein activation";"Prostacyclin signalling through prostacyclin receptor";"Glucagon-type ligand receptors";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"ADP signalling through P2Y purinoceptor 12";"Thromboxane signalling through TP receptor";"G beta:gamma signalling through CDC42";"Ca2+ pathway";"Presynaptic function of Kainate receptors";"G beta:gamma signalling through BTK";"ADP signalling through P2Y purinoceptor 1" XP_046743607.1 3 MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3 "D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis";"Galactose metabolism" XP_046737310.1 14 KEGG: 00600+3.1.3.4;KEGG: 00564+3.1.3.4;Reactome: R-HSA-75109;Reactome: R-HSA-1483191;KEGG: 00561+3.1.3.4;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-8052;KEGG: 00565+3.1.3.4;MetaCyc: PWY-7782;Reactome: R-HSA-4419969;MetaCyc: PWY-8053;Reactome: R-HSA-1483213;MetaCyc: PWY-8055 "Sphingolipid metabolism";"Glycerophospholipid metabolism";"Triglyceride biosynthesis";"Synthesis of PC";"Glycerolipid metabolism";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"2-arachidonoylglycerol biosynthesis";"Ether lipid metabolism";"Plasmalogen biosynthesis";"Depolymerisation of the Nuclear Lamina";"Anandamide biosynthesis II";"Synthesis of PE";"Palmitoyl ethanolamide biosynthesis" XP_046744291.1 12 Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399 "COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy" XP_046744898.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046741934.1 7 MetaCyc: PWY-8043;Reactome: R-HSA-5578999;KEGG: 00270+6.3.2.2;Reactome: R-HSA-174403;MetaCyc: PWY-6840;MetaCyc: PWY-7255;KEGG: 00480+6.3.2.2 "Ophthalmate biosynthesis";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Cysteine and methionine metabolism";"Glutathione synthesis and recycling";"Homoglutathione biosynthesis";"Ergothioneine biosynthesis I (bacteria)";"Glutathione metabolism" XP_046741531.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046746075.1 1 Reactome: R-HSA-1483101 "Synthesis of PS" XP_046737005.1 17 Reactome: R-HSA-69202;Reactome: R-HSA-2559585;Reactome: R-HSA-9616222;Reactome: R-HSA-8953750;Reactome: R-HSA-1912408;Reactome: R-HSA-2173796;Reactome: R-HSA-69656;Reactome: R-HSA-1538133;Reactome: R-HSA-113501;Reactome: R-HSA-2559580;Reactome: R-HSA-69231;Reactome: R-HSA-111448;Reactome: R-HSA-6804114;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-139915;Reactome: R-HSA-69205 "Cyclin E associated events during G1/S transition";"Oncogene Induced Senescence";"Transcriptional regulation of granulopoiesis";"Transcriptional Regulation by E2F6";"Pre-NOTCH Transcription and Translation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Cyclin A:Cdk2-associated events at S phase entry";"G0 and Early G1";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Oxidative Stress Induced Senescence";"Cyclin D associated events in G1";"Activation of NOXA and translocation to mitochondria";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"Activation of PUMA and translocation to mitochondria";"G1/S-Specific Transcription" XP_046748507.1 3 Reactome: R-HSA-2206296;Reactome: R-HSA-2024096;Reactome: R-HSA-2024101 "MPS II - Hunter syndrome";"HS-GAG degradation";"CS/DS degradation" XP_046746026.1 3 MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1 "Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism" XP_046736477.1 2 Reactome: R-HSA-3214847;Reactome: R-HSA-427413 "HATs acetylate histones";"NoRC negatively regulates rRNA expression" XP_046741459.1 42 Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-73772;Reactome: R-HSA-4551638;Reactome: R-HSA-5693565;Reactome: R-HSA-3214842;Reactome: R-HSA-427413;Reactome: R-HSA-5578749;Reactome: R-HSA-2559582;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-2559586;Reactome: R-HSA-1912408;Reactome: R-HSA-3214858;Reactome: R-HSA-8936459;Reactome: R-HSA-427359;Reactome: R-HSA-1221632;Reactome: R-HSA-9610379;Reactome: R-HSA-9616222;Reactome: R-HSA-977225;Reactome: R-HSA-8939236;Reactome: R-HSA-606279;Reactome: R-HSA-5693571;Reactome: R-HSA-3214847;Reactome: R-HSA-3214815;Reactome: R-HSA-5334118;Reactome: R-HSA-110329;Reactome: R-HSA-110331;Reactome: R-HSA-171306;Reactome: R-HSA-2299718;Reactome: R-HSA-110328;Reactome: R-HSA-212300;Reactome: R-HSA-9018519;Reactome: R-HSA-201722;Reactome: R-HSA-5625886;Reactome: R-HSA-3214841;Reactome: R-HSA-73728;Reactome: R-HSA-110330;Reactome: R-HSA-9609690;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-912446 "B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Escape";"SUMOylation of chromatin organization proteins";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDMs demethylate histones";"NoRC negatively regulates rRNA expression";"Transcriptional regulation by small RNAs";"Senescence-Associated Secretory Phenotype (SASP)";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"DNA Damage/Telomere Stress Induced Senescence";"Pre-NOTCH Transcription and Translation";"RMTs methylate histone arginines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SIRT1 negatively regulates rRNA expression";"Meiotic synapsis";"HCMV Late Events";"Transcriptional regulation of granulopoiesis";"Amyloid fiber formation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere";"Nonhomologous End-Joining (NHEJ)";"HATs acetylate histones";"HDACs deacetylate histones";"DNA methylation";"Cleavage of the damaged pyrimidine";"Cleavage of the damaged purine";"Packaging Of Telomere Ends";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"PRC2 methylates histones and DNA";"Estrogen-dependent gene expression";"Formation of the beta-catenin:TCF transactivating complex";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"PKMTs methylate histone lysines";"RNA Polymerase I Promoter Opening";"Recognition and association of DNA glycosylase with site containing an affected purine";"HCMV Early Events";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Meiotic recombination" XP_046754030.1 10 Reactome: R-HSA-917729;Reactome: R-HSA-432720;Reactome: R-HSA-8856825;Reactome: R-HSA-5689880;Reactome: R-HSA-182971;Reactome: R-HSA-9636383;Reactome: R-HSA-9635644;Reactome: R-HSA-8875360;Reactome: R-HSA-8856828;Reactome: R-HSA-6807004 "Endosomal Sorting Complex Required For Transport (ESCRT)";"Lysosome Vesicle Biogenesis";"Cargo recognition for clathrin-mediated endocytosis";"Ub-specific processing proteases";"EGFR downregulation";"Prevention of phagosomal-lysosomal fusion";"Inhibition of membrane repair";"InlB-mediated entry of Listeria monocytogenes into host cell";"Clathrin-mediated endocytosis";"Negative regulation of MET activity" XP_046743942.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046739543.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046744836.1 3 Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429947 "KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Deadenylation of mRNA" XP_046752053.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046748472.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046742557.1 12 Reactome: R-HSA-429947;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-1169408;Reactome: R-HSA-166208;Reactome: R-HSA-72662;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-72649 "Deadenylation of mRNA";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"ISG15 antiviral mechanism";"mTORC1-mediated signalling";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation" XP_046747787.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046743074.1 2 Reactome: R-HSA-72702;Reactome: R-HSA-72706 "Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046734001.1 9 Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-674695 "RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events" XP_046737888.1 7 Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-76061 "RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" XP_046746226.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046741631.1 1 Reactome: R-HSA-427652 "Sodium-coupled phosphate cotransporters" XP_046744732.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" XP_046734138.1 8 Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-5620912;Reactome: R-HSA-6804115;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518 "Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Anchoring of the basal body to the plasma membrane";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2" XP_046734687.1 3 Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046740057.1 14 Reactome: R-HSA-9634638;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-69273;Reactome: R-HSA-5687128;Reactome: R-HSA-141444;Reactome: R-HSA-450520;Reactome: R-HSA-3769402;Reactome: R-HSA-2500257;Reactome: R-HSA-2173788;Reactome: R-HSA-168333;Reactome: R-HSA-165054 "Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Cyclin A/B1/B2 associated events during G2/M transition";"MAPK6/MAPK4 signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HuR (ELAVL1) binds and stabilizes mRNA";"Deactivation of the beta-catenin transactivating complex";"Resolution of Sister Chromatid Cohesion";"Downregulation of TGF-beta receptor signaling";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA" XP_046742571.1 2 MetaCyc: PWY-7851;KEGG: 00770+2.7.1.24 "Coenzyme A biosynthesis II (eukaryotic)";"Pantothenate and CoA biosynthesis" XP_046741054.1 1 Reactome: R-HSA-1221632 "Meiotic synapsis" XP_046753597.1 7 KEGG: 00983+1.1.1.205;MetaCyc: PWY-6596;MetaCyc: PWY-5695;MetaCyc: PWY-7221;Reactome: R-HSA-6798695;Reactome: R-HSA-73817;KEGG: 00230+1.1.1.205 "Drug metabolism - other enzymes";"Adenosine nucleotides degradation I";"Inosine 5'-phosphate degradation";"Guanosine ribonucleotides de novo biosynthesis";"Neutrophil degranulation";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism" XP_046739925.1 7 Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.25;MetaCyc: PWY-2301;MetaCyc: PWY-4702;KEGG: 00521+3.1.3.25 "Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism";"Myo-inositol biosynthesis";"Phytate degradation I";"Streptomycin biosynthesis" XP_046735963.1 6 KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7039;MetaCyc: PWY-7817 "Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046746164.1 5 Reactome: R-HSA-5221030;Reactome: R-HSA-110328;Reactome: R-HSA-3108214;Reactome: R-HSA-110357;Reactome: R-HSA-110329 "TET1,2,3 and TDG demethylate DNA";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"SUMOylation of DNA damage response and repair proteins";"Displacement of DNA glycosylase by APEX1";"Cleavage of the damaged pyrimidine" XP_046747513.1 2 Reactome: R-HSA-2022854;Reactome: R-HSA-975577 "Keratan sulfate biosynthesis";"N-Glycan antennae elongation" XP_046753275.1 19 Reactome: R-HSA-5673000;Reactome: R-HSA-6802952;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-9649948;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-438066;Reactome: R-HSA-399719;Reactome: R-HSA-442982;Reactome: R-HSA-9022692;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-6802946 "RAF activation";"Signaling by BRAF and RAF fusions";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Signaling downstream of RAS mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Unblocking of NMDA receptors, glutamate binding and activation";"Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Regulation of MECP2 expression and activity";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Signaling by moderate kinase activity BRAF mutants" XP_046743094.1 7 KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046741462.1 15 Reactome: R-HSA-2559582;Reactome: R-HSA-174048;Reactome: R-HSA-176407;Reactome: R-HSA-176412;Reactome: R-HSA-2467813;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-174154;Reactome: R-HSA-141430;Reactome: R-HSA-8853884;Reactome: R-HSA-174184;Reactome: R-HSA-176409;Reactome: R-HSA-174084;Reactome: R-HSA-176408;Reactome: R-HSA-179409 "Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Cyclin B";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Phosphorylation of the APC/C";"Separation of Sister Chromatids";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of Securin";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Transcriptional Regulation by VENTX";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of APC/C activators between G1/S and early anaphase";"APC-Cdc20 mediated degradation of Nek2A" XP_046742882.1 3 Reactome: R-HSA-192456;MetaCyc: PWY-6857;KEGG: 00561+3.1.1.3 "Digestion of dietary lipid";"Retinol biosynthesis";"Glycerolipid metabolism" XP_046739864.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046738737.1 4 MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361;Reactome: R-HSA-1237112 "S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Methionine salvage pathway" XP_046738668.1 6 KEGG: 00710+5.1.3.1;KEGG: 00040+5.1.3.1;KEGG: 00030+5.1.3.1;Reactome: R-HSA-71336;MetaCyc: PWY-1861;MetaCyc: PWY-5723 "Carbon fixation in photosynthetic organisms";"Pentose and glucuronate interconversions";"Pentose phosphate pathway";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Rubisco shunt" XP_046736862.1 2 Reactome: R-HSA-168276;Reactome: R-HSA-1169408 "NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism" XP_046743646.1 3 Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369 "Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis" XP_046753301.1 1 Reactome: R-HSA-2428928 "IRS-related events triggered by IGF1R" XP_046739255.1 4 KEGG: 00970+2.9.1.2;Reactome: R-HSA-2408557;MetaCyc: PWY-6281;KEGG: 00450+2.9.1.2 "Aminoacyl-tRNA biosynthesis";"Selenocysteine synthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocompound metabolism" XP_046746108.1 1 Reactome: R-HSA-1971475 "A tetrasaccharide linker sequence is required for GAG synthesis" XP_046750257.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046743588.1 7 Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;MetaCyc: PWY-7511;Reactome: R-HSA-2122948 "Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus" XP_046753334.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046747025.1 11 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-450302;Reactome: R-HSA-171007;KEGG: 05165+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 04926+2.7.11.1;Reactome: R-HSA-2559580 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"activated TAK1 mediates p38 MAPK activation";"p38MAPK events";"Human papillomavirus infection";"VEGFA-VEGFR2 Pathway";"Relaxin signaling pathway";"Oxidative Stress Induced Senescence" XP_046739362.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046742059.1 6 Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-429958 "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease" XP_046736963.1 16 Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706 "SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046740128.1 3 Reactome: R-HSA-5250924;Reactome: R-HSA-72165;Reactome: R-HSA-72163 "B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" XP_046750733.1 1 Reactome: R-HSA-2514853 "Condensation of Prometaphase Chromosomes" XP_046738582.1 6 KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23 "Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Galactose metabolism";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism" XP_046737475.1 4 Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712 "Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport" XP_046745348.1 8 KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04660+2.7.10.2 "mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"T cell receptor signaling pathway" XP_046740704.1 3 Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482 "RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation" XP_046752566.1 2 MetaCyc: PWY-7799;MetaCyc: PWY-7802 "Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)" XP_046751802.1 2 Reactome: R-HSA-2151201;Reactome: R-HSA-400253 "Transcriptional activation of mitochondrial biogenesis";"Circadian Clock" XP_046741612.1 2 Reactome: R-HSA-3295583;Reactome: R-HSA-418890 "TRP channels";"Role of second messengers in netrin-1 signaling" XP_046734702.1 1 Reactome: R-HSA-977347 "Serine biosynthesis" XP_046747916.1 1 Reactome: R-HSA-1474228 "Degradation of the extracellular matrix" XP_046746961.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046737342.1 10 Reactome: R-HSA-167172;Reactome: R-HSA-6807505;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-76042 "Transcription of the HIV genome";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance" XP_046734471.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046753325.1 7 KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046746752.1 11 MetaCyc: PWY-7184;KEGG: 00760+3.6.1.9;MetaCyc: PWY-7821;KEGG: 00500+3.6.1.9;MetaCyc: PWY-7187;KEGG: 00740+3.6.1.9;MetaCyc: PWY-6545;KEGG: 00240+3.6.1.9;MetaCyc: PWY-7206;KEGG: 00230+3.6.1.9;KEGG: 00770+3.6.1.9 "Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Nicotinate and nicotinamide metabolism";"Tunicamycin biosynthesis";"Starch and sucrose metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Riboflavin metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation";"Purine metabolism";"Pantothenate and CoA biosynthesis" XP_046749592.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046742155.1 14 MetaCyc: PWY-6598;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433 "Sciadonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)" XP_046737762.1 1 Reactome: R-HSA-8876725 "Protein methylation" XP_046737409.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression";"PPARA activates gene expression" XP_046739168.1 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" XP_046738302.1 2 Reactome: R-HSA-163282;Reactome: R-HSA-2151201 "Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis" XP_046751703.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" XP_046751476.1 30 Reactome: R-HSA-167162;Reactome: R-HSA-112382;Reactome: R-HSA-73772;Reactome: R-HSA-6781823;Reactome: R-HSA-5696395;Reactome: R-HSA-2564830;Reactome: R-HSA-167246;Reactome: R-HSA-76042;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-167172;Reactome: R-HSA-6781827;Reactome: R-HSA-77075;Reactome: R-HSA-73779;Reactome: R-HSA-427413;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-73776;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-113418;Reactome: R-HSA-73863;Reactome: R-HSA-5696400;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-6782210;Reactome: R-HSA-167161;Reactome: R-HSA-72086 "RNA Polymerase II HIV Promoter Escape";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Formation of Incision Complex in GG-NER";"Cytosolic iron-sulfur cluster assembly";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Transcription of the HIV genome";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Termination";"Dual Incision in GG-NER";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HIV Transcription Initiation";"mRNA Capping" XP_046747716.1 3 Reactome: R-HSA-416476;Reactome: R-HSA-375276;Reactome: R-HSA-881907 "G alpha (q) signalling events";"Peptide ligand-binding receptors";"Gastrin-CREB signalling pathway via PKC and MAPK" XP_046742673.1 3 Reactome: R-HSA-203615;KEGG: 00790+1.1.1.153;Reactome: R-HSA-1474151 "eNOS activation";"Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" XP_046740384.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046747747.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046736185.1 8 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Signaling by Hippo";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection" XP_046752427.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046741100.1 1 Reactome: R-HSA-211897 "Cytochrome P450 - arranged by substrate type" XP_046748345.1 3 Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340 "Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation" XP_046739328.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046737274.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046750546.1 3 MetaCyc: PWY-6482;Reactome: R-HSA-5358493;MetaCyc: PWY-7546 "Diphthamide biosynthesis I (archaea)";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)" XP_046733779.1 18 MetaCyc: PWY-7220;MetaCyc: PWY-7197;MetaCyc: PWY-7184;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7222;MetaCyc: PWY-7187;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7176;MetaCyc: PWY-6545;MetaCyc: PWY-7224;MetaCyc: PWY-7226;MetaCyc: PWY-7210;Reactome: R-HSA-499943;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7227;MetaCyc: PWY-7198;MetaCyc: PWY-7205;MetaCyc: PWY-7221 "Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine deoxyribonucleosides salvage";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"CMP phosphorylation";"Guanosine ribonucleotides de novo biosynthesis" XP_046740986.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046744214.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046752531.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046744192.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046750635.1 9 Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-110314;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-8951664 "Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Neddylation" XP_046747738.1 5 MetaCyc: PWY-6368;KEGG: 04070+3.1.3.64;MetaCyc: PWY-6580;Reactome: R-HSA-1660499;KEGG: 00562+3.1.3.64 "3-phosphoinositide degradation";"Phosphatidylinositol signaling system";"Phosphatidylinositol biosynthesis I (bacteria)";"Synthesis of PIPs at the plasma membrane";"Inositol phosphate metabolism" XP_046737906.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046742676.1 3 Reactome: R-HSA-203615;KEGG: 00790+1.1.1.153;Reactome: R-HSA-1474151 "eNOS activation";"Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" XP_046751037.1 3 Reactome: R-HSA-6798695;Reactome: R-HSA-9609523;Reactome: R-HSA-1660661 "Neutrophil degranulation";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"Sphingolipid de novo biosynthesis" XP_046751184.1 6 Reactome: R-HSA-3000171;Reactome: R-HSA-977225;Reactome: R-HSA-2453864;Reactome: R-HSA-975634;Reactome: R-HSA-6798695;Reactome: R-HSA-2453902 "Non-integrin membrane-ECM interactions";"Amyloid fiber formation";"Retinoid cycle disease events";"Retinoid metabolism and transport";"Neutrophil degranulation";"The canonical retinoid cycle in rods (twilight vision)" XP_046742200.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046745866.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046744426.1 6 Reactome: R-HSA-3214815;Reactome: R-HSA-9022692;Reactome: R-HSA-9022537;Reactome: R-HSA-1989781;Reactome: R-HSA-9029569;Reactome: R-HSA-9609690 "HDACs deacetylate histones";"Regulation of MECP2 expression and activity";"Loss of MECP2 binding ability to the NCoR/SMRT complex";"PPARA activates gene expression";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"HCMV Early Events" XP_046751348.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046749955.1 1 Reactome: R-HSA-5693607 "Processing of DNA double-strand break ends" XP_046737444.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046753817.1 5 Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2559580;Reactome: R-HSA-2871796;Reactome: R-HSA-450321 "Activation of the AP-1 family of transcription factors";"mTOR signaling pathway";"Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" XP_046739311.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046746912.1 1 Reactome: R-HSA-977225 "Amyloid fiber formation" XP_046749725.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046753820.1 2 Reactome: R-HSA-8866654;Reactome: R-HSA-9033241 "E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import" XP_046745753.1 2 Reactome: R-HSA-6807505;Reactome: R-HSA-72163 "RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway" XP_046748500.1 3 Reactome: R-HSA-8875656;Reactome: R-HSA-8856828;Reactome: R-HSA-8854214 "MET receptor recycling";"Clathrin-mediated endocytosis";"TBC/RABGAPs" XP_046735340.1 8 Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-113501;Reactome: R-HSA-174430;Reactome: R-HSA-69091;Reactome: R-HSA-69183;Reactome: R-HSA-68952;Reactome: R-HSA-69166 "Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Telomere C-strand synthesis initiation";"Polymerase switching";"Processive synthesis on the lagging strand";"DNA replication initiation";"Removal of the Flap Intermediate" XP_046740162.1 2 Reactome: R-HSA-8866907;Reactome: R-HSA-8866904 "Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors" XP_046744955.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046734700.1 1 Reactome: R-HSA-977347 "Serine biosynthesis" XP_046735674.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046742918.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-5628897 "Respiratory electron transport";"TP53 Regulates Metabolic Genes" XP_046736167.1 56 Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-75815;Reactome: R-HSA-1236974;Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-983168;Reactome: R-HSA-69601;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-5658442;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8951664;Reactome: R-HSA-450408;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253 "Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway";"Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Antigen processing: Ubiquitination & Proteasome degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of DVL";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RAS by GAPs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex" XP_046736772.1 1 Reactome: R-HSA-380972 "Energy dependent regulation of mTOR by LKB1-AMPK" XP_046744285.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046733766.1 14 MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-7619;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7724;MetaCyc: PWY-6598;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7035 "Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Sciadonate biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis" XP_046745361.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046747932.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046745100.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046746958.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection" XP_046743096.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046739445.1 27 Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-3108214;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-168271;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168276 "Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways" XP_046733876.1 6 KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499;MetaCyc: PWY-6368;KEGG: 00562+3.1.3.66;Reactome: R-HSA-1855183;Reactome: R-HSA-1660516 "Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"3-phosphoinositide degradation";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the early endosome membrane" XP_046744222.1 12 Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295 "Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation" XP_046750112.1 1 Reactome: R-HSA-1483191 "Synthesis of PC" XP_046742060.1 6 Reactome: R-HSA-380994;Reactome: R-HSA-450385;Reactome: R-HSA-429958;Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-450604 "ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA" XP_046737356.1 4 Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825 "DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis" XP_046748787.1 10 Reactome: R-HSA-69205;KEGG: 00670+2.1.1.45;MetaCyc: PWY-7210;MetaCyc: PWY-7184;Reactome: R-HSA-499943;KEGG: 00240+2.1.1.45;MetaCyc: PWY-3841;MetaCyc: PWY-7187;MetaCyc: PWY-7198;MetaCyc: PWY-7199 "G1/S-Specific Transcription";"One carbon pool by folate";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine metabolism";"Folate transformations II (plants)";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleosides salvage" XP_046735165.1 14 MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598 "Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis" XP_046751042.1 7 Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-76061 "RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter" XP_046750246.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046750389.1 7 KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection" XP_046735677.1 6 KEGG: 00040+1.1.1.22;MetaCyc: PWY-7820;KEGG: 00053+1.1.1.22;KEGG: 00520+1.1.1.22;Reactome: R-HSA-173599;MetaCyc: PWY-7346 "Pentose and glucuronate interconversions";"Teichuronic acid biosynthesis (B. subtilis 168)";"Ascorbate and aldarate metabolism";"Amino sugar and nucleotide sugar metabolism";"Formation of the active cofactor, UDP-glucuronate";"UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)" XP_046749373.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046752705.1 2 Reactome: R-HSA-388479;Reactome: R-HSA-416476 "Vasopressin-like receptors";"G alpha (q) signalling events" XP_046741733.1 3 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.14;Reactome: R-HSA-379726 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation" XP_046750851.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046750124.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046743696.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046743283.1 6 Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025 "Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation" XP_046746212.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046747815.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046737123.1 2 KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557 "T cell receptor signaling pathway";"Signaling by SCF-KIT" XP_046733913.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046743699.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046734334.1 4 Reactome: R-HSA-201681;Reactome: R-HSA-418594;Reactome: R-HSA-5689880;Reactome: R-HSA-4641257 "TCF dependent signaling in response to WNT";"G alpha (i) signalling events";"Ub-specific processing proteases";"Degradation of AXIN" XP_046743661.1 5 Reactome: R-HSA-9633012;Reactome: R-HSA-380994;KEGG: 00250+6.3.5.4;Reactome: R-HSA-9648895;Reactome: R-HSA-8963693 "Response of EIF2AK4 (GCN2) to amino acid deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress";"Alanine, aspartate and glutamate metabolism";"Response of EIF2AK1 (HRI) to heme deficiency";"Aspartate and asparagine metabolism" XP_046744829.1 1 Reactome: R-HSA-5656169 "Termination of translesion DNA synthesis" XP_046739307.1 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" XP_046751041.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781 "Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression" XP_046753009.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046739600.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046736756.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046735750.1 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" XP_046748482.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046735978.1 6 Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817 "Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)" XP_046738469.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046746334.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046740940.1 11 Reactome: R-HSA-174430;Reactome: R-HSA-5696397;Reactome: R-HSA-68962;Reactome: R-HSA-6782210;Reactome: R-HSA-5651801;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-68952;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169 "Telomere C-strand synthesis initiation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Activation of the pre-replicative complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"DNA replication initiation";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis" XP_046742450.1 20 MetaCyc: PWY-735;Reactome: R-HSA-9033241;MetaCyc: PWY-7858;MetaCyc: PWY-7726;MetaCyc: PWY-7574;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7340;MetaCyc: PWY-7288;MetaCyc: PWY-6920;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-7337;MetaCyc: PWY-7854;MetaCyc: PWY-7007;KEGG: 00410+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7291;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6837 "Jasmonic acid biosynthesis";"Peroxisomal protein import";"(5Z)-dodecenoate biosynthesis II";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Propanoyl-coa degradation II";"alpha-Linolenic acid metabolism";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"6-gingerol analog biosynthesis (engineered)";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"beta-Alanine metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid degradation";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)" XP_046737555.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046734314.1 16 Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459;Reactome: R-HSA-4086398;Reactome: R-HSA-5687128;Reactome: R-HSA-2559585;Reactome: R-HSA-426496;Reactome: R-HSA-8934593;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-9018519;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700 "Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Ca2+ pathway";"MAPK6/MAPK4 signaling";"Oncogene Induced Senescence";"Post-transcriptional silencing by small RNAs";"Regulation of RUNX1 Expression and Activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Estrogen-dependent gene expression";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation" XP_046739486.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046752310.1 13 Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-156902 "L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation" XP_046747182.1 5 Reactome: R-HSA-211981;Reactome: R-HSA-211945;Reactome: R-HSA-8937144;Reactome: R-HSA-1989781;Reactome: R-HSA-211976 "Xenobiotics";"Phase I - Functionalization of compounds";"Aryl hydrocarbon receptor signalling";"PPARA activates gene expression";"Endogenous sterols" XP_046739834.1 6 Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756 "G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation" XP_046741992.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" XP_046738541.1 1 Reactome: R-HSA-5649702 "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" XP_046746847.1 13 MetaCyc: PWY-7182;MetaCyc: PWY-7709;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-6383;MetaCyc: PWY-5122;MetaCyc: PWY-6859;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-5123;MetaCyc: PWY-7659;MetaCyc: PWY-7721;MetaCyc: PWY-7102 "Linalool biosynthesis I";"(3R)-linalool biosynthesis";"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Geranyl diphosphate biosynthesis";"All-trans-farnesol biosynthesis";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Viridicatumtoxin biosynthesis";"Methyl phomopsenoate biosynthesis";"Bisabolene biosynthesis (engineered)" XP_046752633.1 6 MetaCyc: PWY-6807;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23 "Xyloglucan degradation II (exoglucanase)";"Galactose metabolism";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation" XP_046742923.1 2 Reactome: R-HSA-9029569;Reactome: R-HSA-804914 "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transport of fatty acids" XP_046736689.1 4 Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606 "Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" XP_046738968.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046743630.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046737036.1 13 Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046735215.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046749807.1 39 Reactome: R-HSA-6811558;Reactome: R-HSA-5654704;Reactome: R-HSA-5654706;Reactome: R-HSA-5654227;Reactome: R-HSA-5673001;Reactome: R-HSA-5654695;Reactome: R-HSA-190375;Reactome: R-HSA-5654733;Reactome: R-HSA-5654710;Reactome: R-HSA-5658623;Reactome: R-HSA-5654689;Reactome: R-HSA-5654700;Reactome: R-HSA-1257604;Reactome: R-HSA-5654699;Reactome: R-HSA-190371;Reactome: R-HSA-5654687;Reactome: R-HSA-2033514;Reactome: R-HSA-5654221;Reactome: R-HSA-5654712;Reactome: R-HSA-5654228;Reactome: R-HSA-190322;Reactome: R-HSA-5654727;Reactome: R-HSA-190372;Reactome: R-HSA-8853338;Reactome: R-HSA-5655302;Reactome: R-HSA-190373;Reactome: R-HSA-5654693;Reactome: R-HSA-5654732;Reactome: R-HSA-5654719;Reactome: R-HSA-5655253;Reactome: R-HSA-2033519;Reactome: R-HSA-5654726;Reactome: R-HSA-1839122;Reactome: R-HSA-5654219;Reactome: R-HSA-1839130;Reactome: R-HSA-5654688;Reactome: R-HSA-2219530;Reactome: R-HSA-5654720;Reactome: R-HSA-109704 "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SHC-mediated cascade:FGFR3";"FRS-mediated FGFR3 signaling";"Phospholipase C-mediated cascade, FGFR3";"RAF/MAP kinase cascade";"PI-3K cascade:FGFR2";"FGFR2c ligand binding and activation";"Negative regulation of FGFR4 signaling";"PI-3K cascade:FGFR3";"FGFRL1 modulation of FGFR1 signaling";"PI-3K cascade:FGFR1";"FRS-mediated FGFR2 signaling";"PIP3 activates AKT signaling";"SHC-mediated cascade:FGFR2";"FGFR3b ligand binding and activation";"Downstream signaling of activated FGFR1";"FGFR3 mutant receptor activation";"Phospholipase C-mediated cascade, FGFR2";"FRS-mediated FGFR4 signaling";"Phospholipase C-mediated cascade, FGFR4";"FGFR4 ligand binding and activation";"Negative regulation of FGFR2 signaling";"FGFR3c ligand binding and activation";"Signaling by FGFR3 point mutants in cancer";"Signaling by FGFR1 in disease";"FGFR1c ligand binding and activation";"FRS-mediated FGFR1 signaling";"Negative regulation of FGFR3 signaling";"SHC-mediated cascade:FGFR4";"Signaling by FGFR2 in disease";"Activated point mutants of FGFR2";"Negative regulation of FGFR1 signaling";"Signaling by activated point mutants of FGFR1";"Phospholipase C-mediated cascade: FGFR1";"Signaling by activated point mutants of FGFR3";"SHC-mediated cascade:FGFR1";"Constitutive Signaling by Aberrant PI3K in Cancer";"PI-3K cascade:FGFR4";"PI3K Cascade" XP_046734516.1 8 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Signaling by Hippo";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046746452.1 7 Reactome: R-HSA-5083633;Reactome: R-HSA-5173105;Reactome: R-HSA-5083628;Reactome: R-HSA-3000171;Reactome: R-HSA-5083629;Reactome: R-HSA-3000178;Reactome: R-HSA-9010553 "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"O-linked glycosylation";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Non-integrin membrane-ECM interactions";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"ECM proteoglycans";"Regulation of expression of SLITs and ROBOs" XP_046746950.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection" XP_046744389.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046748875.1 13 Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956 "Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" XP_046748789.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046745112.1 3 KEGG: 00330+1.14.11.2;MetaCyc: PWY-7894;Reactome: R-HSA-1650814 "Arginine and proline metabolism";"Procollagen hydroxylation and glycosylation";"Collagen biosynthesis and modifying enzymes" XP_046746867.1 52 Reactome: R-HSA-6782135;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-112382;Reactome: R-HSA-75953;Reactome: R-HSA-73762;Reactome: R-HSA-6796648;Reactome: R-HSA-76066;Reactome: R-HSA-167172;Reactome: R-HSA-6781827;Reactome: R-HSA-9018519;Reactome: R-HSA-6782210;Reactome: R-HSA-72203;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-75955;Reactome: R-HSA-167160;Reactome: R-HSA-167152;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-5250924;Reactome: R-HSA-749476;Reactome: R-HSA-167246;Reactome: R-HSA-5601884;Reactome: R-HSA-73772;Reactome: R-HSA-167162;Reactome: R-HSA-73780;Reactome: R-HSA-73776;Reactome: R-HSA-76061;Reactome: R-HSA-427413;Reactome: R-HSA-674695;Reactome: R-HSA-203927;Reactome: R-HSA-6807505;Reactome: R-HSA-73779;Reactome: R-HSA-5578749;Reactome: R-HSA-5617472;Reactome: R-HSA-77075;Reactome: R-HSA-73863;Reactome: R-HSA-8851708;Reactome: R-HSA-113418;Reactome: R-HSA-72165;Reactome: R-HSA-167161;Reactome: R-HSA-167287;Reactome: R-HSA-168325;Reactome: R-HSA-72086;Reactome: R-HSA-72163;Reactome: R-HSA-73980;Reactome: R-HSA-167238 "Dual incision in TC-NER";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Transcription of the HIV genome";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Estrogen-dependent gene expression";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Abortive And Retractive Initiation";"Tat-mediated elongation of the HIV-1 transcript";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase I Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase III Chain Elongation";"RNA Polymerase II Promoter Escape";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Pre-transcription Events";"MicroRNA (miRNA) biogenesis";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcriptional regulation by small RNAs";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase I Transcription Termination";"Signaling by FGFR2 IIIa TM";"Formation of the Early Elongation Complex";"mRNA Splicing - Minor Pathway";"HIV Transcription Initiation";"HIV elongation arrest and recovery";"Viral Messenger RNA Synthesis";"mRNA Capping";"mRNA Splicing - Major Pathway";"RNA Polymerase III Transcription Termination";"Pausing and recovery of Tat-mediated HIV elongation" XP_046753613.1 2 Reactome: R-HSA-446203;Reactome: R-HSA-1799339 "Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane" XP_046744211.1 2 MetaCyc: PWY-7799;MetaCyc: PWY-7800 "Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway" XP_046753818.1 5 Reactome: R-HSA-450321;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341;Reactome: R-HSA-2871796;Reactome: R-HSA-2559580 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"mTOR signaling pathway";"Activation of the AP-1 family of transcription factors";"FCERI mediated MAPK activation";"Oxidative Stress Induced Senescence" XP_046741380.1 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" XP_046734323.1 3 Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436 "Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway" XP_046749309.1 4 MetaCyc: PWY-5188;KEGG: 00860+4.2.1.75;Reactome: R-HSA-189451;MetaCyc: PWY-5189 "Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)" XP_046744373.1 12 Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436 "Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic" XP_046750901.1 1 Reactome: R-HSA-3214815 "HDACs deacetylate histones" XP_046749134.1 7 Reactome: R-HSA-1538133;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-69202 "G0 and Early G1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"Cyclin E associated events during G1/S transition" XP_046740286.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046746269.1 3 Reactome: R-HSA-189451;KEGG: 00860+1.3.3.3;MetaCyc: PWY-7159 "Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)" XP_046745695.1 2 KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753 "Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism" XP_046742269.1 1 Reactome: R-HSA-428359 "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" XP_046743272.1 6 KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463 "Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis" XP_046739589.1 5 Reactome: R-HSA-73614;KEGG: 00240+2.4.2.3;KEGG: 00983+2.4.2.3;MetaCyc: PWY-5532;Reactome: R-HSA-73621 "Pyrimidine salvage";"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine catabolism" XP_046745840.1 2 MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Glycerol degradation I";"Glycerolipid metabolism" XP_046743799.1 14 Reactome: R-HSA-6798695;Reactome: R-HSA-193692;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700;Reactome: R-HSA-1474228;Reactome: R-HSA-977225;Reactome: R-HSA-2979096;Reactome: R-HSA-3928665;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-9017802;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-205043 "Neutrophil degranulation";"Regulated proteolysis of p75NTR";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Degradation of the extracellular matrix";"Amyloid fiber formation";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NRIF signals cell death from the nucleus" XP_046741633.1 1 Reactome: R-HSA-427652 "Sodium-coupled phosphate cotransporters" XP_046746432.1 7 Reactome: R-HSA-5083633;Reactome: R-HSA-3000171;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;Reactome: R-HSA-5083628;Reactome: R-HSA-9010553;Reactome: R-HSA-3000178 "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Non-integrin membrane-ECM interactions";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Regulation of expression of SLITs and ROBOs";"ECM proteoglycans" XP_046753369.1 9 MetaCyc: PWY-7117;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5743;MetaCyc: PWY-5744;MetaCyc: PWY-6142;MetaCyc: PWY-241;MetaCyc: PWY-7115;MetaCyc: PWY-5789 "C4 photosynthetic carbon assimilation cycle, PEPCK type";"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"3-hydroxypropanoate cycle";"Glyoxylate assimilation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle" XP_046752630.1 12 Reactome: R-HSA-174362;MetaCyc: PWY-6683;MetaCyc: PWY-5278;KEGG: 00230+2.7.7.4;MetaCyc: PWY-6932;KEGG: 00450+2.7.7.4;MetaCyc: PWY-5340;KEGG: 00230+2.7.1.25;Reactome: R-HSA-2408550;KEGG: 00261+2.7.7.4;KEGG: 00920+2.7.7.4;KEGG: 00920+2.7.1.25 "Transport and synthesis of PAPS";"Assimilatory sulfate reduction III";"Sulfite oxidation III";"Purine metabolism";"Selenate reduction";"Selenocompound metabolism";"Sulfate activation for sulfonation";"Purine metabolism";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Monobactam biosynthesis";"Sulfur metabolism";"Sulfur metabolism" XP_046747521.1 2 Reactome: R-HSA-5689896;Reactome: R-HSA-195253 "Ovarian tumor domain proteases";"Degradation of beta-catenin by the destruction complex" XP_046733834.1 6 Reactome: R-HSA-2892247;Reactome: R-HSA-2892245;Reactome: R-HSA-452723;Reactome: R-HSA-3769402;Reactome: R-HSA-6785807;Reactome: R-HSA-8986944 "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation";"POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation";"Transcriptional regulation of pluripotent stem cells";"Deactivation of the beta-catenin transactivating complex";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional Regulation by MECP2" XP_046743429.1 1 Reactome: R-HSA-1660661 "Sphingolipid de novo biosynthesis" XP_046733897.1 8 Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-8866652;Reactome: R-HSA-6804757;Reactome: R-HSA-5689880;Reactome: R-HSA-6782210;Reactome: R-HSA-8948747;Reactome: R-HSA-6781827 "Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Regulation of TP53 Degradation";"Ub-specific processing proteases";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Regulation of PTEN localization";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)" XP_046751181.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-5576893 "Phase 0 - rapid depolarisation";"Phase 2 - plateau phase" XP_046747160.1 5 Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-73863 "RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination" XP_046752257.1 12 KEGG: 00130+1.14.99.60;MetaCyc: PWY-6708;MetaCyc: PWY-7230;MetaCyc: PWY-5870;MetaCyc: PWY-5873;Reactome: R-HSA-2142789;MetaCyc: PWY-5855;MetaCyc: PWY-5856;MetaCyc: PWY-7233;MetaCyc: PWY-5872;MetaCyc: PWY-5871;MetaCyc: PWY-5857 "Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)" XP_046748994.1 4 Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046752004.1 3 Reactome: R-HSA-110320;Reactome: R-HSA-5685942;Reactome: R-HSA-5656169 "Translesion Synthesis by POLH";"HDR through Homologous Recombination (HRR)";"Termination of translesion DNA synthesis" XP_046750258.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046744634.1 3 MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1 "Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism" XP_046746955.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046743439.1 2 Reactome: R-HSA-425366;Reactome: R-HSA-1483191 "Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC" XP_046734349.1 1 Reactome: R-HSA-427601 "Multifunctional anion exchangers" XP_046750482.1 1 Reactome: R-HSA-1855231 "Synthesis of IPs in the ER lumen" XP_046734705.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046740782.1 18 KEGG: 00592+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7783;Reactome: R-HSA-1482922;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;MetaCyc: PWY-8053;Reactome: R-HSA-1482839;MetaCyc: PWY-7417;Reactome: R-HSA-1482925;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482788;Reactome: R-HSA-1482801;MetaCyc: PWY-8051;KEGG: 00591+3.1.1.4 "alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Plasmalogen degradation";"Acyl chain remodelling of PI";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Synthesis of PA";"Anandamide biosynthesis II";"Acyl chain remodelling of PE";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PG";"Arachidonic acid metabolism";"Acyl chain remodelling of PC";"Acyl chain remodelling of PS";"Anandamide biosynthesis I";"Linoleic acid metabolism" XP_046753199.1 4 MetaCyc: PWY-7494;MetaCyc: PWY-3722;Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1 "Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline catabolism";"Glycine, serine and threonine metabolism" XP_046740517.1 1 Reactome: R-HSA-1221632 "Meiotic synapsis" XP_046750039.1 2 Reactome: R-HSA-8862803;Reactome: R-HSA-69273 "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Cyclin A/B1/B2 associated events during G2/M transition" XP_046747699.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046736267.1 4 Reactome: R-HSA-216083;Reactome: R-HSA-3000170;Reactome: R-HSA-2129379;Reactome: R-HSA-3000178 "Integrin cell surface interactions";"Syndecan interactions";"Molecules associated with elastic fibres";"ECM proteoglycans" XP_046750620.1 1 Reactome: R-HSA-2024096 "HS-GAG degradation" XP_046742674.1 3 Reactome: R-HSA-203615;Reactome: R-HSA-1474151;KEGG: 00790+1.1.1.153 "eNOS activation";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis" XP_046743635.1 3 Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369 "Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis" XP_046749589.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046737899.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046741049.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046749133.1 7 Reactome: R-HSA-156711;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-1362300 "Polo-like kinase mediated events";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" XP_046736878.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046742951.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046746894.1 2 KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221 "Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis" XP_046746911.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046742919.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046747494.1 1 Reactome: R-HSA-611105 "Respiratory electron transport" XP_046734057.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046738543.1 1 Reactome: R-HSA-5649702 "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" XP_046747842.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046740054.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046747847.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046751264.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046750111.1 1 Reactome: R-HSA-1483191 "Synthesis of PC" XP_046746272.1 5 Reactome: R-HSA-4655427;Reactome: R-HSA-212300;Reactome: R-HSA-5334118;Reactome: R-HSA-427413;KEGG: 00270+2.1.1.37 "SUMOylation of DNA methylation proteins";"PRC2 methylates histones and DNA";"DNA methylation";"NoRC negatively regulates rRNA expression";"Cysteine and methionine metabolism" XP_046734145.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046745751.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046745421.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046752707.1 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" XP_046744550.1 1 Reactome: R-HSA-381753 "Olfactory Signaling Pathway" XP_046753943.1 3 Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;Reactome: R-HSA-2206291 "Neutrophil degranulation";"HS-GAG degradation";"MPS IIIC - Sanfilippo syndrome C" XP_046750441.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway" XP_046745812.1 8 Reactome: R-HSA-437239;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1 "Recycling pathway of L1";"Relaxin signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway" XP_046741106.1 4 Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-8953750 "Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"Transcriptional Regulation by E2F6" XP_046735743.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046748624.1 5 Reactome: R-HSA-198323;Reactome: R-HSA-5674400;Reactome: R-HSA-166208;Reactome: R-HSA-165159;Reactome: R-HSA-3371571 "AKT phosphorylates targets in the cytosol";"Constitutive Signaling by AKT1 E17K in Cancer";"mTORC1-mediated signalling";"mTOR signalling";"HSF1-dependent transactivation" XP_046751534.1 1 Reactome: R-HSA-191859 "snRNP Assembly" XP_046750918.1 3 KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596 "Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I" XP_046735294.1 3 Reactome: R-HSA-6794361;Reactome: R-HSA-9609736;Reactome: R-HSA-212676 "Neurexins and neuroligins";"Assembly and cell surface presentation of NMDA receptors";"Dopamine Neurotransmitter Release Cycle" XP_046747639.1 4 Reactome: R-HSA-1799339;Reactome: R-HSA-400511;Reactome: R-HSA-381771;Reactome: R-HSA-422085 "SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and deacylation of Ghrelin" XP_046752810.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046739761.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046742161.1 14 MetaCyc: PWY-7724;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-7725;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6598 "Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis" XP_046751410.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046752898.1 2 Reactome: R-HSA-917729;Reactome: R-HSA-162588 "Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion" XP_046744187.1 12 Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025 "HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation" XP_046745895.1 2 KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936 "Indole alkaloid biosynthesis";"Psilocybin biosynthesis" XP_046746600.1 5 Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-69205 "CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"G1/S-Specific Transcription" XP_046752509.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046735993.1 2 Reactome: R-HSA-1483115;Reactome: R-HSA-1483152 "Hydrolysis of LPC";"Hydrolysis of LPE" XP_046744675.1 13 Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012 "Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency" XP_046753626.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046740359.1 2 Reactome: R-HSA-983231;Reactome: R-HSA-8949215 "Factors involved in megakaryocyte development and platelet production";"Mitochondrial calcium ion transport" XP_046733736.1 1 Reactome: R-HSA-6804759 "Regulation of TP53 Activity through Association with Co-factors" XP_046746163.1 5 Reactome: R-HSA-3108214;Reactome: R-HSA-110328;Reactome: R-HSA-110357;Reactome: R-HSA-5221030;Reactome: R-HSA-110329 "SUMOylation of DNA damage response and repair proteins";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Displacement of DNA glycosylase by APEX1";"TET1,2,3 and TDG demethylate DNA";"Cleavage of the damaged pyrimidine" XP_046746711.1 1 Reactome: R-HSA-525793 "Myogenesis" XP_046752338.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046741233.1 4 Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387 "Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling" XP_046740041.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046741405.1 2 Reactome: R-HSA-163210;Reactome: R-HSA-8949613 "Formation of ATP by chemiosmotic coupling";"Cristae formation" XP_046753908.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046743616.1 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" XP_046739586.1 1 Reactome: R-HSA-1445148 "Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046738166.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046738489.1 10 MetaCyc: PWY-7979;Reactome: R-HSA-162699;KEGG: 00510+2.4.1.83;MetaCyc: PWY-7921;Reactome: R-HSA-4719377;MetaCyc: PWY-7922;Reactome: R-HSA-913709;Reactome: R-HSA-4719360;MetaCyc: PWY-7661;Reactome: R-HSA-4717374 "Protein O-mannosylation III (mammals, core M3)";"Synthesis of dolichyl-phosphate mannose";"N-Glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"O-linked glycosylation of mucins";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Protein N-glycosylation (Haloferax volcanii)";"Defective DPM1 causes DPM1-CDG (CDG-1e)" XP_046740331.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046751069.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046736325.1 2 Reactome: R-HSA-1483166;Reactome: R-HSA-1483148 "Synthesis of PA";"Synthesis of PG" XP_046743629.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046740340.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046735087.1 5 Reactome: R-HSA-6811434;Reactome: R-HSA-6807878;Reactome: R-HSA-204005;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440 "COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"COPII-mediated vesicle transport";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network" XP_046740271.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046734333.1 4 Reactome: R-HSA-4641257;Reactome: R-HSA-418594;Reactome: R-HSA-201681;Reactome: R-HSA-5689880 "Degradation of AXIN";"G alpha (i) signalling events";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases" XP_046734282.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046740870.1 2 Reactome: R-HSA-379716;KEGG: 00970+6.1.1.20 "Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046753768.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046753222.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046745976.1 2 Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28 "Digestion of dietary carbohydrate";"Starch and sucrose metabolism" XP_046742798.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046747759.1 14 MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6598;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-7725;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876 "(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs" XP_046751664.1 1 Reactome: R-HSA-3295583 "TRP channels" XP_046740993.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046734290.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046743036.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046748382.1 27 Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-159230;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-5619107 "HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"snRNP Assembly";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA replication proteins";"HCMV Late Events";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)" XP_046751073.1 56 Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-983168;Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-1236974;Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-4641257;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8951664;Reactome: R-HSA-450408;Reactome: R-HSA-5658442;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174154 "Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ER-Phagosome pathway";"Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Degradation of AXIN";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RAS by GAPs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin" XP_046737134.1 1 Reactome: R-HSA-525793 "Myogenesis" XP_046735538.1 3 KEGG: 00230+2.7.6.1;Reactome: R-HSA-73843;KEGG: 00030+2.7.6.1 "Purine metabolism";"5-Phosphoribose 1-diphosphate biosynthesis";"Pentose phosphate pathway" XP_046747636.1 4 Reactome: R-HSA-381771;Reactome: R-HSA-400511;Reactome: R-HSA-422085;Reactome: R-HSA-1799339 "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin";"SRP-dependent cotranslational protein targeting to membrane" XP_046735261.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046744037.1 4 KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046739023.1 14 MetaCyc: PWY-8053;MetaCyc: PWY-8055;MetaCyc: PWY-5981;MetaCyc: PWY-7417;MetaCyc: PWY-7411;KEGG: 00561+2.3.1.51;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-7589;KEGG: 00564+2.3.1.51 "Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis III";"Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidate biosynthesis (yeast)";"Glycerolipid metabolism";"Synthesis of PA";"Plasmalogen biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Palmitoleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism" XP_046749033.1 2 Reactome: R-HSA-381038;Reactome: R-HSA-1799339 "XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane" XP_046740094.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046740168.1 4 Reactome: R-HSA-379726;Reactome: R-HSA-379716;Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.18 "Mitochondrial tRNA aminoacylation";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis" XP_046749815.1 2 Reactome: R-HSA-204005;Reactome: R-HSA-8876198 "COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs" XP_046747533.1 3 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases" XP_046736492.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046746710.1 1 Reactome: R-HSA-525793 "Myogenesis" XP_046749529.1 4 Reactome: R-HSA-3371453;Reactome: R-HSA-1268020;Reactome: R-HSA-8949613;Reactome: R-HSA-8950505 "Regulation of HSF1-mediated heat shock response";"Mitochondrial protein import";"Cristae formation";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" XP_046747540.1 3 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases" XP_046751460.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046734410.1 7 MetaCyc: PWY-8004;Reactome: R-HSA-71336;KEGG: 00030+3.1.1.31;MetaCyc: PWY-5514;MetaCyc: PWY-6906;MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6 "Entner-Doudoroff pathway I";"Pentose phosphate pathway";"Pentose phosphate pathway";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Chitin derivatives degradation";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism" XP_046751695.1 2 Reactome: R-HSA-1989781;Reactome: R-HSA-2151201 "PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis" XP_046750513.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046740631.1 1 Reactome: R-HSA-388844 "Receptor-type tyrosine-protein phosphatases" XP_046734680.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046737192.1 1 Reactome: R-HSA-156842 "Eukaryotic Translation Elongation" XP_046737631.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046738258.1 27 Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-159230;Reactome: R-HSA-1169408;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-168271;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-170822 "SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA replication proteins";"HCMV Late Events";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein" XP_046734929.1 1 Reactome: R-HSA-6803157 "Antimicrobial peptides" XP_046740489.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046752453.1 2 Reactome: R-HSA-983189;Reactome: R-HSA-6811434 "Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046742619.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046737426.1 2 Reactome: R-HSA-983231;Reactome: R-HSA-383280 "Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway" XP_046753789.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046747601.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046752903.1 5 KEGG: 00740+2.7.1.26;MetaCyc: PWY-6168;MetaCyc: PWY-7863;Reactome: R-HSA-196843;MetaCyc: PWY-5523 "Riboflavin metabolism";"Flavin biosynthesis III (fungi)";"Roseoflavin biosynthesis";"Vitamin B2 (riboflavin) metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)" XP_046747662.1 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" XP_046738074.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046741148.1 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" XP_046738337.1 1 MetaCyc: PWY-6938 "NADH repair" XP_046751496.1 3 MetaCyc: PWY-5386;KEGG: 00620+4.4.1.5;Reactome: R-HSA-70268 "Methylglyoxal degradation I";"Pyruvate metabolism";"Pyruvate metabolism" XP_046741081.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-2022377 "Neutrophil degranulation";"Metabolism of Angiotensinogen to Angiotensins" XP_046737837.1 1 Reactome: R-HSA-3238698 "WNT ligand biogenesis and trafficking" XP_046751701.1 11 Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-9013508;Reactome: R-HSA-72163;Reactome: R-HSA-9013695;Reactome: R-HSA-2173796;Reactome: R-HSA-2122947;Reactome: R-HSA-8941856 "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH3 Intracellular Domain Regulates Transcription";"mRNA Splicing - Major Pathway";"NOTCH4 Intracellular Domain Regulates Transcription";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling" XP_046751060.1 8 MetaCyc: PWY-6580;MetaCyc: PWY-4661;Reactome: R-HSA-1855183;MetaCyc: PWY-6372;MetaCyc: PWY-2301;KEGG: 00562+5.5.1.4;MetaCyc: PWY-6664;KEGG: 00521+5.5.1.4 "Phosphatidylinositol biosynthesis I (bacteria)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Synthesis of IP2, IP, and Ins in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Myo-inositol biosynthesis";"Inositol phosphate metabolism";"Di-myo-inositol phosphate biosynthesis";"Streptomycin biosynthesis" XP_046749849.1 6 Reactome: R-HSA-163560;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-400253;Reactome: R-HSA-2173788;KEGG: 04660+3.1.3.16 "Triglyceride catabolism";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Circadian Clock";"Downregulation of TGF-beta receptor signaling";"T cell receptor signaling pathway" XP_046734194.1 4 KEGG: 00270+1.13.11.20;KEGG: 00430+1.13.11.20;Reactome: R-HSA-1614558;MetaCyc: PWY-5331 "Cysteine and methionine metabolism";"Taurine and hypotaurine metabolism";"Degradation of cysteine and homocysteine";"Taurine biosynthesis I" XP_046750568.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046752923.1 3 Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259 "Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism" XP_046751367.1 2 KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10 "One carbon pool by folate";"Glycine, serine and threonine metabolism" XP_046745164.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046753497.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046747451.1 2 KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981 "Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis" XP_046743424.1 1 Reactome: R-HSA-425410 "Metal ion SLC transporters" XP_046748383.1 27 Reactome: R-HSA-168276;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-3108214;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-191859;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-5619107;Reactome: R-HSA-5578749;Reactome: R-HSA-180746 "NS1 Mediated Effects on Host Pathways";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins";"HCMV Late Events";"SUMOylation of DNA replication proteins";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"snRNP Assembly";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein" XP_046741270.1 3 Reactome: R-HSA-2408508;Reactome: R-HSA-1614603;Reactome: R-HSA-1614558 "Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Cysteine formation from homocysteine";"Degradation of cysteine and homocysteine" XP_046748279.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046753952.1 4 KEGG: 00514+2.4.1.255;MetaCyc: PWY-7437;Reactome: R-HSA-3214847;Reactome: R-HSA-5689603 "Other types of O-glycan biosynthesis";"Protein O-[N-acetyl]-glucosylation";"HATs acetylate histones";"UCH proteinases" XP_046749010.1 1 Reactome: R-HSA-8964038 "LDL clearance" XP_046743075.1 2 Reactome: R-HSA-72702;Reactome: R-HSA-72706 "Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit" XP_046745471.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046751984.1 7 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" XP_046735302.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046752532.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046753012.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046737954.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046750093.1 2 Reactome: R-HSA-9627069;Reactome: R-HSA-111458 "Regulation of the apoptosome activity";"Formation of apoptosome" XP_046747009.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046740554.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046738679.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046745633.1 11 Reactome: R-HSA-5610787;Reactome: R-HSA-418555;Reactome: R-HSA-170670;Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-418594;Reactome: R-HSA-432040;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-163615;Reactome: R-HSA-418597 "Hedgehog 'off' state";"G alpha (s) signalling events";"Adenylate cyclase inhibitory pathway";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Purine metabolism";"Adenylate cyclase activating pathway";"PKA activation";"G alpha (z) signalling events" XP_046741950.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046750384.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046751919.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046747008.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046749887.1 34 Reactome: R-HSA-159230;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-5663220;Reactome: R-HSA-5578749;Reactome: R-HSA-159231;Reactome: R-HSA-2500257;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-141444;Reactome: R-HSA-1169408;Reactome: R-HSA-9639288;Reactome: R-HSA-68877;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-168276;Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-159227;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-191859 "Transport of the SLBP Dependant Mature mRNA";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"RHO GTPases Activate Formins";"Transcriptional regulation by small RNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"Resolution of Sister Chromatid Cohesion";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Late Events";"SUMOylation of DNA replication proteins";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"ISG15 antiviral mechanism";"Amino acids regulate mTORC1";"Mitotic Prometaphase";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"NS1 Mediated Effects on Host Pathways";"HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP independent Mature mRNA";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"snRNP Assembly" XP_046735317.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046753766.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046734765.1 7 MetaCyc: PWY-6824;MetaCyc: PWY-5469;MetaCyc: PWY-7445;MetaCyc: PWY-7214;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461;MetaCyc: PWY-5466 "Justicidin B biosynthesis";"Sesamin biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Phenylpropanoid biosynthesis";"Betanidin degradation";"Matairesinol biosynthesis" XP_046751516.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046742095.1 1 Reactome: R-HSA-77108 "Utilization of Ketone Bodies" XP_046739511.1 2 Reactome: R-HSA-6811438;Reactome: R-HSA-6811440 "Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network" XP_046741708.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840 "NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle" XP_046751009.1 5 Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-5250924 "RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression" XP_046748723.1 7 Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942 "Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition" XP_046747961.1 3 Reactome: R-HSA-6807004;Reactome: R-HSA-202427;Reactome: R-HSA-6798695 "Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation" XP_046748821.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046736467.1 13 Reactome: R-HSA-416572;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5627117;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3928663;Reactome: R-HSA-416482;Reactome: R-HSA-3928662;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Sema4D induced cell migration and growth-cone collapse";"Relaxin signaling pathway";"Human papillomavirus infection";"VEGFA-VEGFR2 Pathway";"Thermogenesis";"Human cytomegalovirus infection";"RHO GTPases Activate ROCKs";"mTOR signaling pathway";"EPHA-mediated growth cone collapse";"G alpha (12/13) signalling events";"EPHB-mediated forward signaling";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046749740.1 9 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-198323;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"AKT phosphorylates targets in the cytosol";"mTOR signaling pathway";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection";"Thermogenesis";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046745694.1 2 Reactome: R-HSA-446203;Reactome: R-HSA-1799339 "Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane" XP_046752980.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046742371.1 8 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Activation of RAC1";"Relaxin signaling pathway";"Human papillomavirus infection" XP_046753429.1 5 KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7269 "Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)" XP_046751748.1 19 Reactome: R-HSA-8964038;Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471;Reactome: R-HSA-8964026;Reactome: R-HSA-8964041;Reactome: R-HSA-8957275;Reactome: R-HSA-3000484;Reactome: R-HSA-8963888;Reactome: R-HSA-8964046;Reactome: R-HSA-3000480;Reactome: R-HSA-8963901;Reactome: R-HSA-3000497;Reactome: R-HSA-8866423;Reactome: R-HSA-432142;Reactome: R-HSA-8856825;Reactome: R-HSA-381426;Reactome: R-HSA-8856828 "LDL clearance";"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors";"Chylomicron clearance";"LDL remodeling";"Post-translational protein phosphorylation";"Scavenging by Class F Receptors";"Chylomicron assembly";"VLDL clearance";"Scavenging by Class A Receptors";"Chylomicron remodeling";"Scavenging by Class H Receptors";"VLDL assembly";"Platelet sensitization by LDL";"Cargo recognition for clathrin-mediated endocytosis";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Clathrin-mediated endocytosis" XP_046735627.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046750923.1 3 Reactome: R-HSA-74217;MetaCyc: PWY-6596;KEGG: 00230+3.5.4.6 "Purine salvage";"Adenosine nucleotides degradation I";"Purine metabolism" XP_046733792.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046747820.1 3 Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286 "Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation" XP_046745122.1 1 Reactome: R-HSA-429958 "mRNA decay by 3' to 5' exoribonuclease" XP_046750641.1 6 Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176187 "Assembly of the pre-replicative complex";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress" XP_046751266.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046747024.1 11 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-450302;Reactome: R-HSA-171007;KEGG: 05165+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 04926+2.7.11.1;Reactome: R-HSA-2559580 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"activated TAK1 mediates p38 MAPK activation";"p38MAPK events";"Human papillomavirus infection";"VEGFA-VEGFR2 Pathway";"Relaxin signaling pathway";"Oxidative Stress Induced Senescence" XP_046753772.1 2 Reactome: R-HSA-429947;Reactome: R-HSA-6804115 "Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" XP_046751811.1 13 Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827 "Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression" XP_046751826.1 1 Reactome: R-HSA-8876725 "Protein methylation" XP_046742881.1 3 KEGG: 00561+3.1.1.3;MetaCyc: PWY-6857;Reactome: R-HSA-192456 "Glycerolipid metabolism";"Retinol biosynthesis";"Digestion of dietary lipid" XP_046741264.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046748739.1 1 Reactome: R-HSA-1614635 "Sulfur amino acid metabolism" XP_046735526.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046753424.1 5 Reactome: R-HSA-196807;MetaCyc: PWY-7268;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;MetaCyc: PWY-5083 "Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation" XP_046746946.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046742214.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046744914.1 3 Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648 "Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK" XP_046738563.1 2 Reactome: R-HSA-6796648;Reactome: R-HSA-6783310 "TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway" XP_046748594.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046741005.1 2 Reactome: R-HSA-1296052;Reactome: R-HSA-418457 "Ca2+ activated K+ channels";"cGMP effects" XP_046754094.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046741392.1 3 Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878 "Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport" XP_046748945.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046748466.1 1 Reactome: R-HSA-611105 "Respiratory electron transport" XP_046752671.1 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" XP_046740048.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046751877.1 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" XP_046744977.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046748577.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046736784.1 15 Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-5358752;Reactome: R-HSA-5467348;Reactome: R-HSA-5467340;Reactome: R-HSA-5358751;Reactome: R-HSA-4641262;Reactome: R-HSA-111465;Reactome: R-HSA-195253;Reactome: R-HSA-3769402;Reactome: R-HSA-5467333;Reactome: R-HSA-5689896;Reactome: R-HSA-5339716 "APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"AXIN missense mutants destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Apoptotic cleavage of cellular proteins";"Degradation of beta-catenin by the destruction complex";"Deactivation of the beta-catenin transactivating complex";"APC truncation mutants are not K63 polyubiquitinated";"Ovarian tumor domain proteases";"Misspliced GSK3beta mutants stabilize beta-catenin" XP_046736904.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046744902.1 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" XP_046741009.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046734116.1 1 Reactome: R-HSA-9609523 "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" XP_046734466.1 5 MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6317;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6527 "D-galactose detoxification";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation" XP_046752687.1 10 MetaCyc: PWY-7112;MetaCyc: PWY-4041;MetaCyc: PWY-4061;MetaCyc: PWY-7559;MetaCyc: PWY-6842;KEGG: 00430+2.3.2.2;MetaCyc: PWY-8001;KEGG: 00460+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-5826 "4-hydroxy-2-nonenal detoxification";"Gamma-glutamyl cycle";"Glutathione-mediated detoxification I";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II";"Taurine and hypotaurine metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Cyanoamino acid metabolism";"Glutathione metabolism";"Hypoglycin biosynthesis" XP_046748046.1 19 Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-6790901;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-8876725;Reactome: R-HSA-3214858 "Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"rRNA modification in the nucleus and cytosol";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Protein methylation";"RMTs methylate histone arginines" XP_046749230.1 4 Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947 "Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription" XP_046746914.1 1 Reactome: R-HSA-977225 "Amyloid fiber formation" XP_046745600.1 4 Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823 "Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex" XP_046749719.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046741398.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782 "Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis" XP_046734124.1 6 Reactome: R-HSA-70221;MetaCyc: PWY-6737;MetaCyc: PWY-5941;MetaCyc: PWY-6731;KEGG: 00500+2.4.1.1;MetaCyc: PWY-7238 "Glycogen breakdown (glycogenolysis)";"Starch degradation V";"Glycogen degradation II";"Starch degradation III";"Starch and sucrose metabolism";"Sucrose biosynthesis II" XP_046743133.1 1 Reactome: R-HSA-8951664 "Neddylation" XP_046745105.1 1 Reactome: R-HSA-5620922 "BBSome-mediated cargo-targeting to cilium" XP_046744151.1 12 Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)" XP_046741781.1 2 KEGG: 00983+3.6.1.23;KEGG: 00240+3.6.1.23 "Drug metabolism - other enzymes";"Pyrimidine metabolism" XP_046739323.1 1 Reactome: R-HSA-1483255 "PI Metabolism" XP_046745314.1 14 Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-426486;Reactome: R-HSA-9029569;Reactome: R-HSA-203927;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-8948700 "Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Small interfering RNA (siRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"MicroRNA (miRNA) biogenesis";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation" XP_046750560.1 6 Reactome: R-HSA-4086398;Reactome: R-HSA-201722;Reactome: R-HSA-4411364;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-8951430 "Ca2+ pathway";"Formation of the beta-catenin:TCF transactivating complex";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"RUNX3 regulates WNT signaling" XP_046751823.1 1 Reactome: R-HSA-8949664 "Processing of SMDT1" XP_046734682.1 3 Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046734915.1 4 Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-350054 "NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway" XP_046751380.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046738063.1 2 Reactome: R-HSA-196741;Reactome: R-HSA-3359473 "Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD" XP_046741989.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046748998.1 4 Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-375165;Reactome: R-HSA-5673001 "COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade" XP_046741923.1 14 MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-7725;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6598 "Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis" XP_046741397.1 6 Reactome: R-HSA-9640463;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7656 "Wax biosynthesis";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis" XP_046753266.1 19 Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-9649948;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-438066;Reactome: R-HSA-5673000;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-6802952;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-111932;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692 "Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Signaling downstream of RAS mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Unblocking of NMDA receptors, glutamate binding and activation";"RAF activation";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Signaling by BRAF and RAF fusions";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity" XP_046743614.1 14 MetaCyc: PWY-8051;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7589;MetaCyc: PWY-5667;MetaCyc: PWY-7587;MetaCyc: PWY-7417;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-8055;Reactome: R-HSA-1483166;MetaCyc: PWY-7782;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7411 "Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Synthesis of PA";"Plasmalogen biosynthesis";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)" XP_046742142.1 2 Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53 "DARPP-32 events";"Purine metabolism" XP_046743638.1 3 MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167 "Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol" XP_046742558.1 12 Reactome: R-HSA-72662;Reactome: R-HSA-166208;Reactome: R-HSA-1169408;Reactome: R-HSA-450408;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72702;Reactome: R-HSA-429947;Reactome: R-HSA-72706;Reactome: R-HSA-975957 "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"mTORC1-mediated signalling";"ISG15 antiviral mechanism";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Ribosomal scanning and start codon recognition";"Deadenylation of mRNA";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046735461.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" XP_046741051.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046734784.1 1 Reactome: R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" XP_046753390.1 19 Reactome: R-HSA-399719;Reactome: R-HSA-442982;Reactome: R-HSA-5673000;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-6802952;Reactome: R-HSA-438066;Reactome: R-HSA-9649948;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-111932;Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-9022692;Reactome: R-HSA-6802955;Reactome: R-HSA-5673001;Reactome: R-HSA-936837 "Trafficking of AMPA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"RAF activation";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Signaling by BRAF and RAF fusions";"Unblocking of NMDA receptors, glutamate binding and activation";"Signaling downstream of RAS mutants";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"CaMK IV-mediated phosphorylation of CREB";"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Regulation of MECP2 expression and activity";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"RAF/MAP kinase cascade";"Ion transport by P-type ATPases" XP_046737311.1 14 MetaCyc: PWY-7782;KEGG: 00565+3.1.3.4;Reactome: R-HSA-1483213;MetaCyc: PWY-8053;MetaCyc: PWY-8055;Reactome: R-HSA-4419969;KEGG: 00564+3.1.3.4;KEGG: 00600+3.1.3.4;MetaCyc: PWY-6453;MetaCyc: PWY-8052;MetaCyc: PWY-8051;KEGG: 00561+3.1.3.4;Reactome: R-HSA-75109;Reactome: R-HSA-1483191 "Plasmalogen biosynthesis";"Ether lipid metabolism";"Synthesis of PE";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis";"Depolymerisation of the Nuclear Lamina";"Glycerophospholipid metabolism";"Sphingolipid metabolism";"Stigma estolide biosynthesis";"2-arachidonoylglycerol biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Triglyceride biosynthesis";"Synthesis of PC" XP_046738256.1 4 KEGG: 00670+2.1.2.9;KEGG: 00970+2.1.2.9;KEGG: 00670+1.5.1.6;Reactome: R-HSA-196757 "One carbon pool by folate";"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"Metabolism of folate and pterines" XP_046736529.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046743097.1 7 KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046752152.1 9 KEGG: 00790+3.5.4.16;MetaCyc: PWY-6983;MetaCyc: PWY-7852;MetaCyc: PWY-5664;Reactome: R-HSA-1474151;MetaCyc: PWY-5663;MetaCyc: PWY-6703;MetaCyc: PWY-7442;MetaCyc: PWY-6147 "Folate biosynthesis";"Threo-tetrahydrobiopterin biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Erythro-tetrahydrobiopterin biosynthesis II";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis I";"Preq0 biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I" XP_046750118.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046746796.1 13 Reactome: R-HSA-114508;Reactome: R-HSA-2029485;Reactome: R-HSA-5218921;Reactome: R-HSA-983695;Reactome: R-HSA-1489509;Reactome: R-HSA-4086398;Reactome: R-HSA-2871809;Reactome: R-HSA-381676;Reactome: R-HSA-112043;Reactome: R-HSA-5578775;Reactome: R-HSA-5607763;Reactome: R-HSA-139853;Reactome: R-HSA-422356 "Effects of PIP2 hydrolysis";"Role of phospholipids in phagocytosis";"VEGFR2 mediated cell proliferation";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"DAG and IP3 signaling";"Ca2+ pathway";"FCERI mediated Ca+2 mobilization";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"PLC beta mediated events";"Ion homeostasis";"CLEC7A (Dectin-1) induces NFAT activation";"Elevation of cytosolic Ca2+ levels";"Regulation of insulin secretion" XP_046734502.1 1 Reactome: R-HSA-425381 "Bicarbonate transporters" XP_046748483.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046748521.1 1 Reactome: R-HSA-2151201 "Transcriptional activation of mitochondrial biogenesis" XP_046735476.1 1 Reactome: R-HSA-5689896 "Ovarian tumor domain proteases" XP_046734038.1 4 KEGG: 00450+6.1.1.10;Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.10 "Selenocompound metabolism";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis" XP_046741063.1 4 Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497 "COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)" XP_046746048.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046751918.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046747894.1 20 Reactome: R-HSA-76042;Reactome: R-HSA-3214847;Reactome: R-HSA-167162;Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-9013508;Reactome: R-HSA-1912408;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-8941856;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-2197563;Reactome: R-HSA-210744 "RNA Polymerase II Transcription Initiation And Promoter Clearance";"HATs acetylate histones";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"NOTCH3 Intracellular Domain Regulates Transcription";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"RUNX3 regulates NOTCH signaling";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"NOTCH2 intracellular domain regulates transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells" XP_046750869.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046740706.1 3 Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213 "Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs" XP_046753008.1 1 Reactome: R-HSA-1296061 "HCN channels" XP_046737517.1 1 Reactome: R-HSA-6790901 "rRNA modification in the nucleus and cytosol" XP_046752224.1 2 Reactome: R-HSA-6807878;Reactome: R-HSA-6811434 "COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic" XP_046744814.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046739794.1 1 Reactome: R-HSA-75105 "Fatty acyl-CoA biosynthesis" XP_046741067.1 9 KEGG: 00910+4.2.1.1;MetaCyc: PWY-5743;Reactome: R-HSA-1475029;MetaCyc: PWY-7117;MetaCyc: PWY-7115;MetaCyc: PWY-5789;MetaCyc: PWY-241;MetaCyc: PWY-6142;MetaCyc: PWY-5744 "Nitrogen metabolism";"3-hydroxypropanoate cycle";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glyoxylate assimilation" XP_046742154.1 14 MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6598;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7725;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601 "(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)" XP_046742784.1 7 Reactome: R-HSA-5696394;Reactome: R-HSA-5689880;Reactome: R-HSA-171319;Reactome: R-HSA-201722;Reactome: R-HSA-5689603;Reactome: R-HSA-3214847;Reactome: R-HSA-606279 "DNA Damage Recognition in GG-NER";"Ub-specific processing proteases";"Telomere Extension By Telomerase";"Formation of the beta-catenin:TCF transactivating complex";"UCH proteinases";"HATs acetylate histones";"Deposition of new CENPA-containing nucleosomes at the centromere" XP_046737674.1 2 Reactome: R-HSA-5357956;Reactome: R-HSA-5357905 "TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling" XP_046752298.1 2 Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5 "Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis" XP_046753246.1 1 Reactome: R-HSA-72203 "Processing of Capped Intron-Containing Pre-mRNA" XP_046739718.1 31 MetaCyc: PWY-7746;MetaCyc: PWY-5366;MetaCyc: PWY-7723;MetaCyc: PWY-5994;Reactome: R-HSA-163765;MetaCyc: PWY-8049;Reactome: R-HSA-9029558;MetaCyc: PWY-8012;Reactome: R-HSA-199220;MetaCyc: PWY-7858;MetaCyc: PWY-5147;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-2426168;Reactome: R-HSA-75105;MetaCyc: PWY-7663;MetaCyc: PWY-6113;MetaCyc: PWY-7664;MetaCyc: PWY-5971;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388;MetaCyc: PWY-5367;MetaCyc: PWY-6799;MetaCyc: PWY-5973;MetaCyc: PWY-4381;MetaCyc: PWY-8047;MetaCyc: PWY-5142;MetaCyc: PWY-6519;MetaCyc: PWY-6282;MetaCyc: PWY-5989;MetaCyc: PWYG-321 "Mycobacterial sulfolipid biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Bacterial bioluminescence";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"ChREBP activates metabolic gene expression";"Pederin biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Mupirocin biosynthesis";"Vitamin B5 (pantothenate) metabolism";"(5Z)-dodecenoate biosynthesis II";"Oleate biosynthesis I (plants)";"Biotin metabolism";"Activation of gene expression by SREBF (SREBP)";"Fatty acyl-CoA biosynthesis";"Gondoate biosynthesis (anaerobic)";"Superpathway of mycolate biosynthesis";"Oleate biosynthesis IV (anaerobic)";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Fatty acid biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Bryostatin biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"8-amino-7-oxononanoate biosynthesis I";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Stearate biosynthesis II (bacteria and plants)";"" XP_046747918.1 26 Reactome: R-HSA-1368082;Reactome: R-HSA-3214847;Reactome: R-HSA-3899300;Reactome: R-HSA-1234158;Reactome: R-HSA-918233;Reactome: R-HSA-381340;Reactome: R-HSA-400253;Reactome: R-HSA-9614657;Reactome: R-HSA-2122947;Reactome: R-HSA-5621575;Reactome: R-HSA-9013508;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-5617472;Reactome: R-HSA-9013695;Reactome: R-HSA-201722;Reactome: R-HSA-2644606;Reactome: R-HSA-1912408;Reactome: R-HSA-3371568;Reactome: R-HSA-2894862;Reactome: R-HSA-9617629;Reactome: R-HSA-8941856;Reactome: R-HSA-8866907;Reactome: R-HSA-3134973;Reactome: R-HSA-210744;Reactome: R-HSA-933541 "RORA activates gene expression";"HATs acetylate histones";"SUMOylation of transcription cofactors";"Regulation of gene expression by Hypoxia-inducible Factor";"TRAF3-dependent IRF activation pathway";"Transcriptional regulation of white adipocyte differentiation";"Circadian Clock";"FOXO-mediated transcription of cell death genes";"NOTCH1 Intracellular Domain Regulates Transcription";"CD209 (DC-SIGN) signaling";"NOTCH3 Intracellular Domain Regulates Transcription";"PPARA activates gene expression";"Estrogen-dependent gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"NOTCH4 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"Attenuation phase";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulation of FOXO transcriptional activity by acetylation";"RUNX3 regulates NOTCH signaling";"Activation of the TFAP2 (AP-2) family of transcription factors";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"TRAF6 mediated IRF7 activation" XP_046737583.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046737585.1 1 Reactome: R-HSA-71384 "Ethanol oxidation" XP_046751724.1 2 Reactome: R-HSA-8949664;Reactome: R-HSA-8949215 "Processing of SMDT1";"Mitochondrial calcium ion transport" XP_046746499.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046749221.1 3 KEGG: 00790+2.10.1.1;MetaCyc: PWY-6823;Reactome: R-HSA-947581 "Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis" XP_046740616.1 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" XP_046754036.1 56 Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-983168;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-75815;Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-1236974;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-5658442;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-8854050;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8951664;Reactome: R-HSA-450408;Reactome: R-HSA-4641257 "NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of DVL";"Downstream TCR signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"ER-Phagosome pathway";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RAS by GAPs";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN" XP_046736808.1 5 Reactome: R-HSA-5625740;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-75035 "RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" XP_046744967.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046736888.1 1 KEGG: 00970+6.1.1.20 "Aminoacyl-tRNA biosynthesis" XP_046743748.1 4 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway" XP_046741709.1 3 Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648 "G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK" XP_046745266.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046753250.1 19 Reactome: R-HSA-438066;Reactome: R-HSA-9649948;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-5673000;Reactome: R-HSA-6802952;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-442982;Reactome: R-HSA-399719;Reactome: R-HSA-6802955;Reactome: R-HSA-936837;Reactome: R-HSA-5673001;Reactome: R-HSA-9022692;Reactome: R-HSA-6802946;Reactome: R-HSA-9617324;Reactome: R-HSA-3371571;Reactome: R-HSA-9620244;Reactome: R-HSA-111932 "Unblocking of NMDA receptors, glutamate binding and activation";"Signaling downstream of RAS mutants";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"RAF activation";"Signaling by BRAF and RAF fusions";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Ras activation upon Ca2+ influx through NMDA receptor";"Trafficking of AMPA receptors";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ion transport by P-type ATPases";"RAF/MAP kinase cascade";"Regulation of MECP2 expression and activity";"Signaling by moderate kinase activity BRAF mutants";"Negative regulation of NMDA receptor-mediated neuronal transmission";"HSF1-dependent transactivation";"Long-term potentiation";"CaMK IV-mediated phosphorylation of CREB" XP_046745705.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046745768.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046747123.1 13 Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827 "Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression" XP_046744173.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway" XP_046747609.1 2 Reactome: R-HSA-195253;Reactome: R-HSA-5689896 "Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases" XP_046753567.1 14 KEGG: 00720+1.3.5.1;MetaCyc: PWY-561;KEGG: 00020+1.3.5.1;MetaCyc: PWY-4302;MetaCyc: PWY-7279;MetaCyc: PWY-5690;MetaCyc: PWY-3781;MetaCyc: PWY-6728;Reactome: R-HSA-611105;KEGG: 00190+1.3.5.1;MetaCyc: PWY-6969;Reactome: R-HSA-71403;KEGG: 00650+1.3.5.1;MetaCyc: PWY-7254 "Carbon fixation pathways in prokaryotes";"Superpathway of glyoxylate cycle and fatty acid degradation";"Citrate cycle (TCA cycle)";"Aerobic respiration III (alternative oxidase pathway)";"Aerobic respiration II (cytochrome c) (yeast)";"TCA cycle II (plants and fungi)";"Aerobic respiration I (cytochrome c)";"Methylaspartate cycle";"Respiratory electron transport";"Oxidative phosphorylation";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citric acid cycle (TCA cycle)";"Butanoate metabolism";"TCA cycle VII (acetate-producers)" XP_046749160.1 1 Reactome: R-HSA-1268020 "Mitochondrial protein import" XP_046741322.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046744417.1 1 Reactome: R-HSA-6798163 "Choline catabolism" XP_046738784.1 3 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6811440 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network" XP_046745790.1 2 Reactome: R-HSA-196780;Reactome: R-HSA-3371599 "Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency" XP_046739390.1 3 Reactome: R-HSA-392154;Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2 "Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction";"Purine metabolism" XP_046741299.1 1 Reactome: R-HSA-1483148 "Synthesis of PG" XP_046736003.1 1 Reactome: R-HSA-1296072 "Voltage gated Potassium channels" XP_046747632.1 2 Reactome: R-HSA-8876198;Reactome: R-HSA-5357905 "RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling" XP_046740133.1 2 Reactome: R-HSA-8986944;Reactome: R-HSA-203927 "Transcriptional Regulation by MECP2";"MicroRNA (miRNA) biogenesis" XP_046734404.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046745612.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046746141.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046747125.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046747615.1 5 Reactome: R-HSA-204005;Reactome: R-HSA-5694530;Reactome: R-HSA-2132295;Reactome: R-HSA-983170;Reactome: R-HSA-1655829 "COPII-mediated vesicle transport";"Cargo concentration in the ER";"MHC class II antigen presentation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of cholesterol biosynthesis by SREBP (SREBF)" XP_046739759.1 5 Reactome: R-HSA-3108214;Reactome: R-HSA-110357;Reactome: R-HSA-110328;Reactome: R-HSA-5221030;Reactome: R-HSA-110329 "SUMOylation of DNA damage response and repair proteins";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"TET1,2,3 and TDG demethylate DNA";"Cleavage of the damaged pyrimidine" XP_046750806.1 8 Reactome: R-HSA-164378;Reactome: R-HSA-983231;Reactome: R-HSA-381676;Reactome: R-HSA-5610787;Reactome: R-HSA-442720;Reactome: R-HSA-163615;Reactome: R-HSA-180024;Reactome: R-HSA-432040 "PKA activation in glucagon signalling";"Factors involved in megakaryocyte development and platelet production";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Hedgehog 'off' state";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"PKA activation";"DARPP-32 events";"Vasopressin regulates renal water homeostasis via Aquaporins" XP_046752672.1 1 KEGG: 04070+2.7.11.13 "Phosphatidylinositol signaling system" XP_046748995.1 4 Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-5673001;Reactome: R-HSA-375165 "Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth" XP_046743060.1 5 MetaCyc: PWY-5189;Reactome: R-HSA-189451;KEGG: 00260+2.3.1.37;KEGG: 00860+2.3.1.37;MetaCyc: PWY-7536 "Tetrapyrrole biosynthesis II (from glycine)";"Heme biosynthesis";"Glycine, serine and threonine metabolism";"Porphyrin and chlorophyll metabolism";"2-amino-3-hydroxycyclopent-2-enone biosynthesis" XP_046739069.1 9 MetaCyc: PWY-5744;MetaCyc: PWY-6142;MetaCyc: PWY-241;MetaCyc: PWY-7115;MetaCyc: PWY-5789;MetaCyc: PWY-7117;Reactome: R-HSA-1475029;MetaCyc: PWY-5743;KEGG: 00910+4.2.1.1 "Glyoxylate assimilation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Reversible hydration of carbon dioxide";"3-hydroxypropanoate cycle";"Nitrogen metabolism" XP_046742995.1 1 Reactome: R-HSA-435368 "Zinc efflux and compartmentalization by the SLC30 family" XP_046752490.1 1 Reactome: R-HSA-912446 "Meiotic recombination" XP_046751920.1 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" XP_046747534.1 3 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases" XP_046735655.1 3 Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066 "RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter" XP_046746589.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046748717.1 7 Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380284 "Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome" XP_046744231.1 12 Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9646399;Reactome: R-HSA-141444 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046743695.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046751825.1 1 Reactome: R-HSA-8876725 "Protein methylation" XP_046741857.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046741026.1 2 Reactome: R-HSA-418457;Reactome: R-HSA-1296052 "cGMP effects";"Ca2+ activated K+ channels" XP_046746648.1 7 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection" XP_046739738.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046750123.1 2 Reactome: R-HSA-8939243;Reactome: R-HSA-3214858 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines" XP_046751173.1 2 Reactome: R-HSA-5576893;Reactome: R-HSA-5576892 "Phase 2 - plateau phase";"Phase 0 - rapid depolarisation" XP_046748311.1 7 Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-156711 "Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G0 and Early G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"Polo-like kinase mediated events" XP_046742297.1 3 Reactome: R-HSA-111367;Reactome: R-HSA-73856;Reactome: R-HSA-77588 "SLBP independent Processing of Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" XP_046748259.1 3 KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154 "Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase" XP_046735641.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046746100.1 10 Reactome: R-HSA-1855191;MetaCyc: PWY-6362;MetaCyc: PWY-6369;KEGG: 04070+2.7.1.158;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6372;Reactome: R-HSA-1855167;MetaCyc: PWY-4661;MetaCyc: PWY-6361;MetaCyc: PWY-6554 "Synthesis of IPs in the nucleus";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)" XP_046742981.1 1 Reactome: R-HSA-2022377 "Metabolism of Angiotensinogen to Angiotensins" XP_046740658.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046743665.1 7 MetaCyc: PWY-6824;MetaCyc: PWY-5469;MetaCyc: PWY-7445;MetaCyc: PWY-7214;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461;MetaCyc: PWY-5466 "Justicidin B biosynthesis";"Sesamin biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Phenylpropanoid biosynthesis";"Betanidin degradation";"Matairesinol biosynthesis" XP_046753619.1 13 Reactome: R-HSA-450302;Reactome: R-HSA-168638;Reactome: R-HSA-5357956;Reactome: R-HSA-937072;Reactome: R-HSA-9645460;Reactome: R-HSA-937042;Reactome: R-HSA-2871837;Reactome: R-HSA-9014325;Reactome: R-HSA-5607764;Reactome: R-HSA-9020702;Reactome: R-HSA-975163;Reactome: R-HSA-450321;Reactome: R-HSA-445989 "activated TAK1 mediates p38 MAPK activation";"NOD1/2 Signaling Pathway";"TNFR1-induced NFkappaB signaling pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Alpha-protein kinase 1 signaling pathway";"IRAK2 mediated activation of TAK1 complex";"FCERI mediated NF-kB activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"CLEC7A (Dectin-1) signaling";"Interleukin-1 signaling";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex" XP_046750119.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046741994.1 2 Reactome: R-HSA-379716;Reactome: R-HSA-2408522 "Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism" XP_046744756.1 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" XP_046752254.1 3 Reactome: R-HSA-426048;KEGG: 00561+3.1.1.23;MetaCyc: PWY-7420 "Arachidonate production from DAG";"Glycerolipid metabolism";"Monoacylglycerol metabolism (yeast)" XP_046752619.1 3 MetaCyc: PWY-7999;KEGG: 00130+4.1.1.90;Reactome: R-HSA-159740 "Vitamin K-epoxide cycle";"Ubiquinone and other terpenoid-quinone biosynthesis";"Gamma-carboxylation of protein precursors" XP_046739129.1 6 Reactome: R-HSA-72163;Reactome: R-HSA-975957;Reactome: R-HSA-72187;Reactome: R-HSA-9010553;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA Splicing - Major Pathway";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA 3'-end processing";"Regulation of expression of SLITs and ROBOs";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046749977.1 2 Reactome: R-HSA-445095;Reactome: R-HSA-5576892 "Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation" XP_046734142.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046737289.1 12 Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295 "Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation" XP_046733786.1 15 Reactome: R-HSA-5693571;Reactome: R-HSA-5693616;Reactome: R-HSA-2559586;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-5693548;Reactome: R-HSA-5685942;Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5685939;Reactome: R-HSA-5693554;Reactome: R-HSA-912446;Reactome: R-HSA-5685938 "Nonhomologous End-Joining (NHEJ)";"Presynaptic phase of homologous DNA pairing and strand exchange";"DNA Damage/Telomere Stress Induced Senescence";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Sensing of DNA Double Strand Breaks";"HDR through Homologous Recombination (HRR)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"HDR through MMEJ (alt-NHEJ)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Meiotic recombination";"HDR through Single Strand Annealing (SSA)" XP_046734699.1 1 Reactome: R-HSA-977347 "Serine biosynthesis" XP_046745797.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046750514.1 1 Reactome: R-HSA-383280 "Nuclear Receptor transcription pathway" XP_046746716.1 1 Reactome: R-HSA-197264 "Nicotinamide salvaging" XP_046753694.1 13 Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-6791226 "Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046750584.1 1 Reactome: R-HSA-163560 "Triglyceride catabolism" XP_046735767.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046734403.1 14 Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-167287;Reactome: R-HSA-167242;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167238 "Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"HIV elongation arrest and recovery";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of Tat-mediated HIV elongation" XP_046745755.1 2 Reactome: R-HSA-6807505;Reactome: R-HSA-72163 "RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway" XP_046739345.1 1 Reactome: R-HSA-5223345 "Miscellaneous transport and binding events" XP_046740787.1 2 KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1 "Pentose phosphate pathway";"Purine metabolism" XP_046744438.1 1 KEGG: 04150+2.7.11.24 "mTOR signaling pathway" XP_046735459.1 1 Reactome: R-HSA-212300 "PRC2 methylates histones and DNA" XP_046735910.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046734814.1 2 Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46 "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism" XP_046744419.1 12 Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-2467813 "COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Separation of Sister Chromatids" XP_046742934.1 2 KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710 "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)" XP_046737402.1 56 Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-1236974;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-75815;Reactome: R-HSA-5358346;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-983168;Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-202424;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8951664;Reactome: R-HSA-450408;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-5658442;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837 "Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"ER-Phagosome pathway";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog ligand biogenesis";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Antigen processing: Ubiquitination & Proteasome degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Downstream TCR signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RAS by GAPs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation" XP_046734477.1 10 Reactome: R-HSA-6798695;MetaCyc: PWY-7394;MetaCyc: PWY-7849;Reactome: R-HSA-975634;Reactome: R-HSA-977225;Reactome: R-HSA-2453902;MetaCyc: PWY-5691;Reactome: R-HSA-2453864;KEGG: 00230+3.5.2.17;Reactome: R-HSA-3000171 "Neutrophil degranulation";"Urate conversion to allantoin II";"Urate conversion to allantoin III";"Retinoid metabolism and transport";"Amyloid fiber formation";"The canonical retinoid cycle in rods (twilight vision)";"Urate conversion to allantoin I";"Retinoid cycle disease events";"Purine metabolism";"Non-integrin membrane-ECM interactions" XP_046745620.1 1 Reactome: R-HSA-425561 "Sodium/Calcium exchangers" XP_046746962.1 7 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway" XP_046745938.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046736856.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046751780.1 1 Reactome: R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" XP_046743756.1 4 Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163 "Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway" XP_046747808.1 12 MetaCyc: PWY-5870;MetaCyc: PWY-6708;MetaCyc: PWY-5873;MetaCyc: PWY-5855;MetaCyc: PWY-5856;Reactome: R-HSA-2142789;Reactome: R-HSA-1268020;KEGG: 00130+2.5.1.39;MetaCyc: PWY-5871;MetaCyc: PWY-5872;MetaCyc: PWY-6978;MetaCyc: PWY-5857 "Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Mitochondrial protein import";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol-10 biosynthesis (prokaryotic)" XP_046738138.1 8 Reactome: R-HSA-983231;Reactome: R-HSA-381676;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-180024;Reactome: R-HSA-432040;Reactome: R-HSA-442720;Reactome: R-HSA-163615 "Factors involved in megakaryocyte development and platelet production";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"DARPP-32 events";"Vasopressin regulates renal water homeostasis via Aquaporins";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"PKA activation" XP_046742538.1 7 KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;KEGG: 00562+3.1.4.11;MetaCyc: PWY-8052;Reactome: R-HSA-1855204;MetaCyc: PWY-7039;MetaCyc: PWY-6351 "Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"Inositol phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis" XP_046747538.1 27 Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-6784531;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-180910 "SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"tRNA processing in the nucleus";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs" XP_046746213.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046753019.1 4 KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193 "Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I" XP_046736476.1 1 Reactome: R-HSA-71403 "Citric acid cycle (TCA cycle)" XP_046741093.1 2 Reactome: R-HSA-5696394;Reactome: R-HSA-5689603 "DNA Damage Recognition in GG-NER";"UCH proteinases" XP_046745741.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046747142.1 1 Reactome: R-HSA-3371453 "Regulation of HSF1-mediated heat shock response" XP_046742370.1 8 Reactome: R-HSA-428540;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Activation of RAC1";"Human papillomavirus infection";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis" XP_046740580.1 10 Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-9018519;Reactome: R-HSA-167172 "RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"Estrogen-dependent gene expression";"Transcription of the HIV genome" XP_046752900.1 2 Reactome: R-HSA-162588;Reactome: R-HSA-917729 "Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)" XP_046738519.1 2 Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58 "Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis" XP_046744740.1 6 KEGG: 00512+2.4.1.122;Reactome: R-HSA-913709;MetaCyc: PWY-7433;KEGG: 00514+2.4.1.122;MetaCyc: PWY-7290;Reactome: R-HSA-5083632 "Mucin type O-glycan biosynthesis";"O-linked glycosylation of mucins";"Mucin core 1 and core 2 O-glycosylation";"Other types of O-glycan biosynthesis";"Escherichia coli serotype O86 O-antigen biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)" XP_046749665.1 5 Reactome: R-HSA-111469;Reactome: R-HSA-111457;Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-9627069 "SMAC, XIAP-regulated apoptotic response";"Release of apoptotic factors from the mitochondria";"SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Regulation of the apoptosome activity" XP_046742830.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046736183.1 8 KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human papillomavirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Signaling by Hippo";"Human cytomegalovirus infection";"Thermogenesis" XP_046738955.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046738628.1 2 Reactome: R-HSA-936837;Reactome: R-HSA-6798695 "Ion transport by P-type ATPases";"Neutrophil degranulation" XP_046744159.1 12 Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-9646399 "COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy" XP_046736384.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046739175.1 2 Reactome: R-HSA-399719;Reactome: R-HSA-190873 "Trafficking of AMPA receptors";"Gap junction degradation" XP_046744237.1 12 Reactome: R-HSA-141444;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Aggrephagy";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)" XP_046735819.1 8 KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1 "Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Major pathway of rRNA processing in the nucleolus and cytosol";"Human papillomavirus infection";"Relaxin signaling pathway" XP_046740851.1 1 Reactome: R-HSA-196843 "Vitamin B2 (riboflavin) metabolism" XP_046737758.1 7 Reactome: R-HSA-201681;Reactome: R-HSA-4641262;Reactome: R-HSA-5663220;Reactome: R-HSA-5368598;Reactome: R-HSA-201688;Reactome: R-HSA-4641258;Reactome: R-HSA-4086400 "TCF dependent signaling in response to WNT";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RHO GTPases Activate Formins";"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"WNT mediated activation of DVL";"Degradation of DVL";"PCP/CE pathway" XP_046751829.1 1 Reactome: R-HSA-5662702 "Melanin biosynthesis" XP_046748135.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046748136.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046742696.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046745246.1 2 Reactome: R-HSA-6799198;Reactome: R-HSA-611105 "Complex I biogenesis";"Respiratory electron transport" XP_046746660.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046734319.1 16 Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8853884;Reactome: R-HSA-8936459;Reactome: R-HSA-4086398;Reactome: R-HSA-2559585;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-8934593;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-9018519;Reactome: R-HSA-8943723;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700 "Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by VENTX";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Ca2+ pathway";"Oncogene Induced Senescence";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"Regulation of RUNX1 Expression and Activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"Estrogen-dependent gene expression";"Regulation of PTEN mRNA translation";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation" XP_046746884.1 1 Reactome: R-HSA-8955332 "Carboxyterminal post-translational modifications of tubulin" XP_046734580.1 8 Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-165054;Reactome: R-HSA-2500257 "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion" XP_046750253.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046738814.1 7 KEGG: 00630+2.3.3.9;MetaCyc: PWY-7854;MetaCyc: PWY-7295;MetaCyc: PWY-7118;MetaCyc: PWY-7294;KEGG: 00620+2.3.3.9;MetaCyc: PWY-6969 "Glyoxylate and dicarboxylate metabolism";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"L-arabinose degradation IV";"Chitin degradation to ethanol";"D-xylose degradation IV";"Pyruvate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)" XP_046742216.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046750895.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046752289.1 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046751267.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-8964038 "Neutrophil degranulation";"LDL clearance" XP_046737407.1 13 Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-3000171;Reactome: R-HSA-186797;Reactome: R-HSA-2243919;Reactome: R-HSA-3000178;Reactome: R-HSA-3000157;Reactome: R-HSA-1650814;Reactome: R-HSA-2214320;Reactome: R-HSA-419037;Reactome: R-HSA-216083;Reactome: R-HSA-2022090;Reactome: R-HSA-1474244 "Collagen chain trimerization";"Collagen degradation";"Non-integrin membrane-ECM interactions";"Signaling by PDGF";"Crosslinking of collagen fibrils";"ECM proteoglycans";"Laminin interactions";"Collagen biosynthesis and modifying enzymes";"Anchoring fibril formation";"NCAM1 interactions";"Integrin cell surface interactions";"Assembly of collagen fibrils and other multimeric structures";"Extracellular matrix organization" XP_046751538.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination" XP_046739831.1 1 Reactome: R-HSA-5693565 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" XP_046741173.1 3 KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16 "T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer" XP_046742912.1 2 Reactome: R-HSA-2142700;Reactome: R-HSA-2142691 "Synthesis of Lipoxins (LX)";"Synthesis of Leukotrienes (LT) and Eoxins (EX)" XP_046750664.1 4 Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-427389 "Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" XP_046748714.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046752891.1 1 Reactome: R-HSA-418990 "Adherens junctions interactions" XP_046737791.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046747784.1 3 MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1 "Diethylphosphate degradation";"Thiamine metabolism";"Folate biosynthesis" XP_046736039.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046738418.1 1 Reactome: R-HSA-5693571 "Nonhomologous End-Joining (NHEJ)" XP_046751241.1 1 Reactome: R-HSA-390648 "Muscarinic acetylcholine receptors" XP_046750176.1 4 Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72764 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination" XP_046737258.1 5 Reactome: R-HSA-6798695;Reactome: R-HSA-75109;Reactome: R-HSA-1482883;KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20 "Neutrophil degranulation";"Triglyceride biosynthesis";"Acyl chain remodeling of DAG and TAG";"Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism" XP_046734390.1 3 MetaCyc: PWY-8106;MetaCyc: PWY-6700;Reactome: R-HSA-6782315 "Queuosine biosynthesis III (queuosine salvage)";"Queuosine biosynthesis I (de novo)";"tRNA modification in the nucleus and cytosol" XP_046752827.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046739538.1 7 Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220 "Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins" XP_046753172.1 5 Reactome: R-HSA-446210;MetaCyc: PWY-6749;MetaCyc: PWY-8013;KEGG: 00250+2.6.1.16;KEGG: 00520+2.6.1.16 "Synthesis of UDP-N-acetyl-glucosamine";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Amino sugar and nucleotide sugar metabolism" XP_046739304.1 5 Reactome: R-HSA-8856828;Reactome: R-HSA-190873;Reactome: R-HSA-3928665;Reactome: R-HSA-8856825;Reactome: R-HSA-196025 "Clathrin-mediated endocytosis";"Gap junction degradation";"EPH-ephrin mediated repulsion of cells";"Cargo recognition for clathrin-mediated endocytosis";"Formation of annular gap junctions" XP_046743639.1 3 MetaCyc: PWY-6369;Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21 "Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system" XP_046734081.1 9 Reactome: R-HSA-9639288;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-6798695;Reactome: R-HSA-5674135 "Amino acids regulate mTORC1";"Macroautophagy";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription";"mTOR signalling";"Neutrophil degranulation";"MAP2K and MAPK activation" XP_046747341.1 1 Reactome: R-HSA-75153 "Apoptotic execution phase" XP_046753470.1 18 MetaCyc: PWY-7416;KEGG: 00592+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-6803;Reactome: R-HSA-1482922;MetaCyc: PWY-7783;MetaCyc: PWY-8053;MetaCyc: PWY-7417;Reactome: R-HSA-1482839;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;MetaCyc: PWY-8051;Reactome: R-HSA-1482801;KEGG: 00591+3.1.1.4;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482925;Reactome: R-HSA-1482788 "Phospholipid remodeling (phosphatidylcholine, yeast)";"alpha-Linolenic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PI";"Plasmalogen degradation";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PE";"Glycerophospholipid metabolism";"Synthesis of PA";"Anandamide biosynthesis I";"Acyl chain remodelling of PS";"Linoleic acid metabolism";"Arachidonic acid metabolism";"Acyl chain remodelling of PG";"Acyl chain remodelling of PC" XP_046734659.1 2 MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8 "Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism" XP_046744758.1 1 Reactome: R-HSA-110320 "Translesion Synthesis by POLH" XP_046740368.1 1 Reactome: R-HSA-6802952 "Signaling by BRAF and RAF fusions" XP_046742087.1 1 Reactome: R-HSA-1369062 "ABC transporters in lipid homeostasis" XP_046740003.1 5 KEGG: 00230+6.3.2.6;Reactome: R-HSA-73817;MetaCyc: PWY-6123;MetaCyc: PWY-7234;MetaCyc: PWY-6124 "Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis II" XP_046753643.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046752604.1 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" XP_046734773.1 2 Reactome: R-HSA-6804115;Reactome: R-HSA-429947 "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA" XP_046738326.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046739741.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046741837.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046744838.1 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046745933.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046741617.1 2 Reactome: R-HSA-418890;Reactome: R-HSA-3295583 "Role of second messengers in netrin-1 signaling";"TRP channels" XP_046737383.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046740557.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046739342.1 4 Reactome: R-HSA-382556;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-5358346 "ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Hedgehog ligand biogenesis" XP_046743019.1 1 Reactome: R-HSA-1237044 "Erythrocytes take up carbon dioxide and release oxygen" XP_046741697.1 1 Reactome: R-HSA-8949613 "Cristae formation" XP_046753021.1 13 KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-7822 "Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"CS/DS degradation";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation";"Chitin degradation III (Serratia)" XP_046752503.1 13 KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;Reactome: R-HSA-2022857;MetaCyc: PWY-7883;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-6902;MetaCyc: PWY-7822 "Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"CS/DS degradation";"Glycosphingolipid metabolism";"Keratan sulfate degradation";"Anhydromuropeptides recycling II";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)" XP_046738036.1 8 MetaCyc: PWY-7197;KEGG: 00240+2.7.4.9;MetaCyc: PWY-6545;MetaCyc: PWY-7198;MetaCyc: PWY-7187;Reactome: R-HSA-499943;MetaCyc: PWY-7210;MetaCyc: PWY-7184 "Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I" XP_046744701.1 2 Reactome: R-HSA-6798695;Reactome: R-HSA-3238698 "Neutrophil degranulation";"WNT ligand biogenesis and trafficking" XP_046741530.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046747543.1 1 Reactome: R-HSA-2470946 "Cohesin Loading onto Chromatin" XP_046747588.1 1 Reactome: R-HSA-5689880 "Ub-specific processing proteases" XP_046735469.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-71403 "Respiratory electron transport";"Citric acid cycle (TCA cycle)" XP_046747904.1 5 KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7921;MetaCyc: PWY-7922 "Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)" XP_046742710.1 1 Reactome: R-HSA-71384 "Ethanol oxidation" XP_046749342.1 6 Reactome: R-HSA-6804759;Reactome: R-HSA-6803211;Reactome: R-HSA-139915;Reactome: R-HSA-6803207;Reactome: R-HSA-6803204;Reactome: R-HSA-6803205 "Regulation of TP53 Activity through Association with Co-factors";"TP53 Regulates Transcription of Death Receptors and Ligands";"Activation of PUMA and translocation to mitochondria";"TP53 Regulates Transcription of Caspase Activators and Caspases";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" XP_046751983.1 7 KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1 "Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis" XP_046741225.1 8 Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68689;Reactome: R-HSA-68962;Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68867;Reactome: R-HSA-68616 "Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"CDC6 association with the ORC:origin complex";"Activation of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Assembly of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication" XP_046744529.1 6 Reactome: R-HSA-5693565;Reactome: R-HSA-5675221;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-8939211 "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Negative regulation of MAPK pathway";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"ESR-mediated signaling" XP_046738581.1 6 MetaCyc: PWY-6807;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23 "Xyloglucan degradation II (exoglucanase)";"Galactose metabolism";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation" XP_046739920.1 5 Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-3247509;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695 "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"Chromatin modifying enzymes";"RMTs methylate histone arginines";"Interleukin-7 signaling" XP_046749590.1 2 Reactome: R-HSA-445355;Reactome: R-HSA-390522 "Smooth Muscle Contraction";"Striated Muscle Contraction" XP_046752285.1 2 Reactome: R-HSA-8856828;Reactome: R-HSA-8856825 "Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis" XP_046748719.1 7 Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942 "AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition" XP_046738170.1 7 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046746043.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046749683.1 14 MetaCyc: PWY-7589;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-7782;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5981;MetaCyc: PWY-7417;MetaCyc: PWY-8053;MetaCyc: PWY-8055 "Palmitoleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Plasmalogen biosynthesis";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Palmitoyl ethanolamide biosynthesis" XP_046748469.1 1 Reactome: R-HSA-936837 "Ion transport by P-type ATPases" XP_046746380.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046734497.1 12 KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-418885;Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416476;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1 "Human cytomegalovirus infection";"Thermogenesis";"G alpha (12/13) signalling events";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"DCC mediated attractive signaling";"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (q) signalling events";"Relaxin signaling pathway";"Human papillomavirus infection" XP_046743884.1 3 Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955 "Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation" XP_046735191.1 12 MetaCyc: PWY-5132;KEGG: 00010+6.2.1.1;KEGG: 00630+6.2.1.1;MetaCyc: PWY-5108;MetaCyc: PWY-6672;KEGG: 00620+6.2.1.1;MetaCyc: PWY-7857;KEGG: 00720+6.2.1.1;KEGG: 00640+6.2.1.1;MetaCyc: PWY-5133;KEGG: 00680+6.2.1.1;MetaCyc: PWY-7118 "Lupulone and humulone biosynthesis";"Glycolysis / Gluconeogenesis";"Glyoxylate and dicarboxylate metabolism";"L-isoleucine biosynthesis V";"Cis-genanyl-coa degradation";"Pyruvate metabolism";"Adlupulone and adhumulone biosynthesis";"Carbon fixation pathways in prokaryotes";"Propanoate metabolism";"Colupulone and cohumulone biosynthesis";"Methane metabolism";"Chitin degradation to ethanol" XP_046745781.1 3 Reactome: R-HSA-1483191;Reactome: R-HSA-422085;Reactome: R-HSA-112311 "Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin";"Neurotransmitter clearance" XP_046734423.1 6 MetaCyc: PWY-7391;KEGG: 00900+4.1.1.33;MetaCyc: PWY-922;Reactome: R-HSA-2426168;Reactome: R-HSA-446199;Reactome: R-HSA-191273 "Isoprene biosynthesis II (engineered)";"Terpenoid backbone biosynthesis";"Mevalonate pathway I";"Activation of gene expression by SREBF (SREBP)";"Synthesis of Dolichyl-phosphate";"Cholesterol biosynthesis" XP_046746580.1 1 MetaCyc: PWY-7511 "Protein ubiquitination" XP_046738328.1 1 Reactome: R-HSA-420499 "Class C/3 (Metabotropic glutamate/pheromone receptors)" XP_046749135.1 7 Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-69202 "G0 and Early G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"Cyclin E associated events during G1/S transition" XP_046743202.1 8 Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-6798695 "Amino acids regulate mTORC1";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Macroautophagy";"Regulation of PTEN gene transcription";"mTOR signalling";"Neutrophil degranulation" XP_046750172.1 4 KEGG: 00510+2.7.1.108;MetaCyc: PWY-6129;Reactome: R-HSA-4755583;Reactome: R-HSA-446199 "N-Glycan biosynthesis";"Dolichol and dolichyl phosphate biosynthesis";"Defective DOLK causes DOLK-CDG (CDG-1m)";"Synthesis of Dolichyl-phosphate" XP_046742804.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046741965.1 2 Reactome: R-HSA-1799339;Reactome: R-HSA-1236974 "SRP-dependent cotranslational protein targeting to membrane";"ER-Phagosome pathway" XP_046740371.1 11 Reactome: R-HSA-1834949;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693571;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-8866654;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-3270619 "Cytosolic sensors of pathogen-associated DNA";"mTOR signaling pathway";"Nonhomologous End-Joining (NHEJ)";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Human cytomegalovirus infection";"E3 ubiquitin ligases ubiquitinate target proteins";"Human papillomavirus infection";"Relaxin signaling pathway";"IRF3-mediated induction of type I IFN" XP_046747530.1 3 Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837 "Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases" XP_046733968.1 1 Reactome: R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" XP_046741320.1 12 Reactome: R-HSA-9013695;Reactome: R-HSA-9013508;Reactome: R-HSA-210744;Reactome: R-HSA-8941856;Reactome: R-HSA-2122947;Reactome: R-HSA-73762;Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-5250924;Reactome: R-HSA-2644606 "NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"RUNX3 regulates NOTCH signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"RNA Polymerase I Transcription Initiation";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"B-WICH complex positively regulates rRNA expression";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" XP_046737173.1 2 Reactome: R-HSA-5083635;Reactome: R-HSA-5173214 "Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins" XP_046746811.1 1 MetaCyc: PWY-6829 "Trna methylation (yeast)" XP_046752491.1 1 Reactome: R-HSA-912446 "Meiotic recombination" XP_046748223.1 1 Reactome: R-HSA-390522 "Striated Muscle Contraction" XP_046753667.1 4 MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-6902 "Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)" XP_046744033.1 4 MetaCyc: PWY-6902;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822 "Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)" XP_046750854.1 2 Reactome: R-HSA-72165;Reactome: R-HSA-72163 "mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway" XP_046744335.1 2 Reactome: R-HSA-3299685;MetaCyc: PWY-6854 "Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)" XP_046739542.1 1 Reactome: R-HSA-83936 "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" XP_046738075.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046740186.1 1 Reactome: R-HSA-162791 "Attachment of GPI anchor to uPAR" XP_046735909.1 6 MetaCyc: PWY-7817;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039 "Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule" XP_046733800.1 1 MetaCyc: PWY-7533 "Gliotoxin biosynthesis" XP_046746687.1 1 Reactome: R-HSA-6799198 "Complex I biogenesis" XP_046748016.1 3 KEGG: 00510+2.4.1.117;Reactome: R-HSA-913709;Reactome: R-HSA-480985 "N-Glycan biosynthesis";"O-linked glycosylation of mucins";"Synthesis of dolichyl-phosphate-glucose" XP_046750698.1 2 Reactome: R-HSA-4570571;Reactome: R-HSA-446193 "Defective RFT1 causes RFT1-CDG (CDG-1n)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein" XP_046745716.1 2 KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041 "Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II" XP_046747427.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046753482.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046742695.1 1 Reactome: R-HSA-204005 "COPII-mediated vesicle transport" XP_046748091.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046744487.1 3 Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594 "Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events" XP_046739528.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046753839.1 8 KEGG: 00983+3.5.4.5;MetaCyc: PWY-7181;MetaCyc: PWY-6556;Reactome: R-HSA-73614;Reactome: R-HSA-6798695;KEGG: 00240+3.5.4.5;MetaCyc: PWY-7199;MetaCyc: PWY-7193 "Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleosides degradation";"Pyrimidine ribonucleosides salvage II";"Pyrimidine salvage";"Neutrophil degranulation";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleosides salvage";"Pyrimidine ribonucleosides salvage I" XP_046750493.1 22 Reactome: R-HSA-196299;Reactome: R-HSA-6811558;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-432142;Reactome: R-HSA-5358749;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-5358747;Reactome: R-HSA-5673000;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-5358752;Reactome: R-HSA-4641262;Reactome: R-HSA-2500257;Reactome: R-HSA-5675221;Reactome: R-HSA-5339716 "Beta-catenin phosphorylation cascade";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Platelet sensitization by LDL";"S37 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"S33 mutants of beta-catenin aren't phosphorylated";"RAF activation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"T41 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Resolution of Sister Chromatid Cohesion";"Negative regulation of MAPK pathway";"Misspliced GSK3beta mutants stabilize beta-catenin" XP_046742874.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046752088.1 1 Reactome: R-HSA-2465910 "MASTL Facilitates Mitotic Progression" XP_046747132.1 15 Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-176034;Reactome: R-HSA-167152;Reactome: R-HSA-6807505;Reactome: R-HSA-9018519;Reactome: R-HSA-167238;Reactome: R-HSA-2173796;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167200 "Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Interactions of Tat with host cellular proteins";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA polymerase II transcribes snRNA genes";"Estrogen-dependent gene expression";"Pausing and recovery of Tat-mediated HIV elongation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat" XP_046749727.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046741144.1 6 Reactome: R-HSA-189085;MetaCyc: PWY-622;MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1;MetaCyc: PWY-7900;KEGG: 00500+2.4.1.18 "Digestion of dietary carbohydrate";"Starch biosynthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism" XP_046754003.1 3 MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783 "Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis" XP_046740888.1 1 Reactome: R-HSA-156584 "Cytosolic sulfonation of small molecules" XP_046751048.1 1 Reactome: R-HSA-216083 "Integrin cell surface interactions" XP_046734316.1 16 Reactome: R-HSA-8936459;Reactome: R-HSA-8853884;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-2559585;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-4086398;Reactome: R-HSA-9029569;Reactome: R-HSA-8934593;Reactome: R-HSA-2559580;Reactome: R-HSA-8948700;Reactome: R-HSA-8943723;Reactome: R-HSA-9018519;Reactome: R-HSA-9022692 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by VENTX";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Oncogene Induced Senescence";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"Ca2+ pathway";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of RUNX1 Expression and Activity";"Oxidative Stress Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of PTEN mRNA translation";"Estrogen-dependent gene expression";"Regulation of MECP2 expression and activity" XP_046746782.1 2 Reactome: R-HSA-6802953;Reactome: R-HSA-5658442 "RAS signaling downstream of NF1 loss-of-function variants";"Regulation of RAS by GAPs" XP_046746105.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046751606.1 4 Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-674695 "Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events" XP_046734222.1 11 Reactome: R-HSA-418594;Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-418597;Reactome: R-HSA-5610787;Reactome: R-HSA-418555;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-164378 "G alpha (i) signalling events";"Adenylate cyclase activating pathway";"Purine metabolism";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"G alpha (z) signalling events";"Hedgehog 'off' state";"G alpha (s) signalling events";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling" XP_046741679.1 1 KEGG: 00970+6.1.1.21 "Aminoacyl-tRNA biosynthesis" XP_046751305.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046736131.1 1 Reactome: R-HSA-420029 "Tight junction interactions" XP_046749709.1 1 Reactome: R-HSA-8850843 "Phosphate bond hydrolysis by NTPDase proteins" XP_046742462.1 3 Reactome: R-HSA-5423646;Reactome: R-HSA-2142691;MetaCyc: PWY-7533 "Aflatoxin activation and detoxification";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis" XP_046749568.1 2 Reactome: R-HSA-390522;Reactome: R-HSA-445355 "Striated Muscle Contraction";"Smooth Muscle Contraction" XP_046746364.1 3 Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840 "Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation" XP_046741603.1 3 KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348 "Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition" XP_046734657.1 7 Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942 "Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition" XP_046736771.1 1 Reactome: R-HSA-1632852 "Macroautophagy" XP_046743643.1 3 MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167 "Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol" XP_046735207.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046738986.1 3 Reactome: R-HSA-9033241;Reactome: R-HSA-8866654;Reactome: R-HSA-9603798 "Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Class I peroxisomal membrane protein import" XP_046744010.1 3 Reactome: R-HSA-156590;KEGG: 00680+3.1.2.12;MetaCyc: PWY-1801 "Glutathione conjugation";"Methane metabolism";"Formaldehyde oxidation II (glutathione-dependent)" XP_046752489.1 12 Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-2132295;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-381038 "Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"MHC class II antigen presentation";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"XBP1(S) activates chaperone genes" XP_046740332.1 6 Reactome: R-HSA-399997;Reactome: R-HSA-428930;Reactome: R-HSA-456926;Reactome: R-HSA-418592;Reactome: R-HSA-434316;Reactome: R-HSA-416476 "Acetylcholine regulates insulin secretion";"Thromboxane signalling through TP receptor";"Thrombin signalling through proteinase activated receptors (PARs)";"ADP signalling through P2Y purinoceptor 1";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G alpha (q) signalling events" XP_046743877.1 6 KEGG: 00780+6.3.4.15;Reactome: R-HSA-196780;Reactome: R-HSA-3371599;MetaCyc: PWY-6987;MetaCyc: PWY-7382;KEGG: 00785+2.3.1.181 "Biotin metabolism";"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism" XP_046741778.1 56 Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-4641258;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-350562;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-75815;Reactome: R-HSA-1236974;Reactome: R-HSA-5632684;Reactome: R-HSA-8941858;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5689880;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-5610783;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-195253;Reactome: R-HSA-5658442;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-174154;Reactome: R-HSA-4641257;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-450408 "G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of DVL";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of ornithine decarboxylase (ODC)";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway";"Hedgehog 'on' state";"Regulation of RUNX3 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ub-specific processing proteases";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Degradation of GLI2 by the proteasome";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of beta-catenin by the destruction complex";"Regulation of RAS by GAPs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"APC/C:Cdc20 mediated degradation of Securin";"Degradation of AXIN";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"AUF1 (hnRNP D0) binds and destabilizes mRNA" XP_046744402.1 12 Reactome: R-HSA-9646399;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878 "Aggrephagy";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport" XP_046742032.1 5 Reactome: R-HSA-1368108;Reactome: R-HSA-6798695;MetaCyc: PWY-5381;Reactome: R-HSA-197264;KEGG: 00760+6.3.4.21 "BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Neutrophil degranulation";"Pyridine nucleotide cycling (plants)";"Nicotinamide salvaging";"Nicotinate and nicotinamide metabolism" XP_046744737.1 6 KEGG: 00512+2.4.1.122;MetaCyc: PWY-7290;Reactome: R-HSA-5083632;KEGG: 00514+2.4.1.122;Reactome: R-HSA-913709;MetaCyc: PWY-7433 "Mucin type O-glycan biosynthesis";"Escherichia coli serotype O86 O-antigen biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Other types of O-glycan biosynthesis";"O-linked glycosylation of mucins";"Mucin core 1 and core 2 O-glycosylation" XP_046741045.1 1 Reactome: R-HSA-194840 "Rho GTPase cycle" XP_046738125.1 2 Reactome: R-HSA-202733;Reactome: R-HSA-416993 "Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors" XP_046752479.1 18 MetaCyc: PWY-7783;Reactome: R-HSA-1482922;MetaCyc: PWY-6803;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-1482925;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482788;Reactome: R-HSA-1482801;MetaCyc: PWY-8051;KEGG: 00591+3.1.1.4;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;MetaCyc: PWY-8053;Reactome: R-HSA-1482839;MetaCyc: PWY-7417 "Plasmalogen degradation";"Acyl chain remodelling of PI";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PG";"Arachidonic acid metabolism";"Acyl chain remodelling of PC";"Acyl chain remodelling of PS";"Anandamide biosynthesis I";"Linoleic acid metabolism";"Glycerophospholipid metabolism";"Synthesis of PA";"Anandamide biosynthesis II";"Acyl chain remodelling of PE";"Phospholipid remodeling (phosphatidate, yeast)" XP_046735745.1 1 Reactome: R-HSA-212436 "Generic Transcription Pathway" XP_046740055.1 2 Reactome: R-HSA-6811436;Reactome: R-HSA-8876198 "COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs" XP_046736038.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046741982.1 2 Reactome: R-HSA-72163;Reactome: R-HSA-72165 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway" XP_046737252.1 5 Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187 "Unwinding of DNA";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress" XP_046740272.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046745978.1 2 Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28 "Digestion of dietary carbohydrate";"Starch and sucrose metabolism" XP_046750044.1 6 KEGG: 00510+2.4.1.143;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578;Reactome: R-HSA-4793952 "N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)" XP_046738218.1 16 Reactome: R-HSA-8951664;Reactome: R-HSA-167152;Reactome: R-HSA-167238;Reactome: R-HSA-167287;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-9010553;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-983168;Reactome: R-HSA-180585;Reactome: R-HSA-1234176;Reactome: R-HSA-674695;Reactome: R-HSA-6796648 "Neddylation";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of Tat-mediated HIV elongation";"HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Regulation of expression of SLITs and ROBOs";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Antigen processing: Ubiquitination & Proteasome degradation";"Vif-mediated degradation of APOBEC3G";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes" XP_046735094.1 1 Reactome: R-HSA-6798695 "Neutrophil degranulation" XP_046737240.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046747320.1 26 Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-380320;Reactome: R-HSA-437239;Reactome: R-HSA-9648025;Reactome: R-HSA-389977;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-389960;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-9646399;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-6811436;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-8852276 "Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"Recruitment of NuMA to mitotic centrosomes";"Recycling pathway of L1";"EML4 and NUDC in mitotic spindle formation";"Post-chaperonin tubulin folding pathway";"Cilium Assembly";"Separation of Sister Chromatids";"Formation of tubulin folding intermediates by CCT/TriC";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"HCMV Early Events";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"Aggrephagy";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"COPI-independent Golgi-to-ER retrograde traffic";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint" XP_046734220.1 11 Reactome: R-HSA-170670;Reactome: R-HSA-418555;Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-432040;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660 "Adenylate cyclase inhibitory pathway";"G alpha (s) signalling events";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"Hedgehog 'off' state";"PKA activation";"G alpha (z) signalling events";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Purine metabolism";"Adenylate cyclase activating pathway" XP_046751455.1 56 Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-5362768;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-202424;Reactome: R-HSA-4641258;Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-187577;Reactome: R-HSA-5676590;Reactome: R-HSA-4641257;Reactome: R-HSA-450408;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-68949;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-349425;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5689880;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751 "ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Downstream TCR signaling";"Degradation of DVL";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"SCF(Skp2)-mediated degradation of p27/p21";"NIK-->noncanonical NF-kB signaling";"Degradation of AXIN";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Orc1 removal from chromatin";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Autodegradation of the E3 ubiquitin ligase COP1";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Ub-specific processing proteases";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity" XP_046738015.1 1 Reactome: R-HSA-72163 "mRNA Splicing - Major Pathway" XP_046752628.1 12 MetaCyc: PWY-6683;Reactome: R-HSA-174362;MetaCyc: PWY-5278;KEGG: 00230+2.7.7.4;MetaCyc: PWY-6932;KEGG: 00230+2.7.1.25;KEGG: 00450+2.7.7.4;MetaCyc: PWY-5340;Reactome: R-HSA-2408550;KEGG: 00261+2.7.7.4;KEGG: 00920+2.7.1.25;KEGG: 00920+2.7.7.4 "Assimilatory sulfate reduction III";"Transport and synthesis of PAPS";"Sulfite oxidation III";"Purine metabolism";"Selenate reduction";"Purine metabolism";"Selenocompound metabolism";"Sulfate activation for sulfonation";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Monobactam biosynthesis";"Sulfur metabolism";"Sulfur metabolism" XP_046739308.1 1 Reactome: R-HSA-6784531 "tRNA processing in the nucleus" XP_046745061.1 13 Reactome: R-HSA-5218920;Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-5674400;Reactome: R-HSA-166208;Reactome: R-HSA-9639288;Reactome: R-HSA-3371571;Reactome: R-HSA-6804757;Reactome: R-HSA-389357;Reactome: R-HSA-165159;Reactome: R-HSA-1257604;Reactome: R-HSA-8943724 "VEGFR2 mediated vascular permeability";"Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Constitutive Signaling by AKT1 E17K in Cancer";"mTORC1-mediated signalling";"Amino acids regulate mTORC1";"HSF1-dependent transactivation";"Regulation of TP53 Degradation";"CD28 dependent PI3K/Akt signaling";"mTOR signalling";"PIP3 activates AKT signaling";"Regulation of PTEN gene transcription" XP_046747144.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046742613.1 1 Reactome: R-HSA-6794361 "Neurexins and neuroligins" XP_046735280.1 16 Reactome: R-HSA-1234176;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-983168;Reactome: R-HSA-180585;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-9010553;Reactome: R-HSA-112382;Reactome: R-HSA-167287;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167152;Reactome: R-HSA-167238;Reactome: R-HSA-8951664 "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Antigen processing: Ubiquitination & Proteasome degradation";"Vif-mediated degradation of APOBEC3G";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Regulation of expression of SLITs and ROBOs";"Formation of RNA Pol II elongation complex";"HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Neddylation" XP_046737911.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046747546.1 27 Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-159227;Reactome: R-HSA-4570464;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-3108214;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-168271;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377 "tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins" XP_046748550.1 2 Reactome: R-HSA-8951664;Reactome: R-HSA-983168 "Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046752364.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046740130.1 12 Reactome: R-HSA-167287;Reactome: R-HSA-6804756;Reactome: R-HSA-167200;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167152;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-112382 "HIV elongation arrest and recovery";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex" XP_046733906.1 14 MetaCyc: PWY-5497;Reactome: R-HSA-196757;MetaCyc: PWY-3661-1;KEGG: 00680+2.1.2.1;KEGG: 00260+2.1.2.1;KEGG: 00460+2.1.2.1;MetaCyc: PWY-3661;KEGG: 00670+2.1.2.1;MetaCyc: PWY-3841;MetaCyc: PWY-181;MetaCyc: PWY-2201;MetaCyc: PWY-1622;MetaCyc: PWY-2161;KEGG: 00630+2.1.2.1 "Purine nucleobases degradation II (anaerobic)";"Metabolism of folate and pterines";"Glycine betaine degradation II (mammalian)";"Methane metabolism";"Glycine, serine and threonine metabolism";"Cyanoamino acid metabolism";"Glycine betaine degradation I";"One carbon pool by folate";"Folate transformations II (plants)";"Photorespiration ";"Folate transformations I";"Formaldehyde assimilation I (serine pathway)";"Folate polyglutamylation";"Glyoxylate and dicarboxylate metabolism" XP_046736737.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046740447.1 22 Reactome: R-HSA-5467348;Reactome: R-HSA-6811558;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-68877;Reactome: R-HSA-432142;Reactome: R-HSA-5663220;Reactome: R-HSA-5467340;Reactome: R-HSA-5358751;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-9648025;Reactome: R-HSA-5673000;Reactome: R-HSA-5358747;Reactome: R-HSA-2500257;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-4641262 "Truncations of AMER1 destabilize the destruction complex";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"Mitotic Prometaphase";"Platelet sensitization by LDL";"RHO GTPases Activate Formins";"AXIN missense mutants destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"EML4 and NUDC in mitotic spindle formation";"RAF activation";"S33 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"Disassembly of the destruction complex and recruitment of AXIN to the membrane" XP_046751990.1 3 Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482 "NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events" XP_046735048.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046739164.1 1 Reactome: R-HSA-211945 "Phase I - Functionalization of compounds" XP_046749985.1 2 Reactome: R-HSA-5576892;Reactome: R-HSA-445095 "Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins" XP_046735708.1 5 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-77595 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs" XP_046745887.1 1 Reactome: R-HSA-162710 "Synthesis of glycosylphosphatidylinositol (GPI)" XP_046746585.1 3 Reactome: R-HSA-75109;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30 "Triglyceride biosynthesis";"Glycerol degradation I";"Glycerolipid metabolism" XP_046734310.1 3 MetaCyc: PWY-6558;KEGG: 00534+5.1.3.17;Reactome: R-HSA-2022928 "Heparan sulfate biosynthesis (late stages)";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"HS-GAG biosynthesis" XP_046752482.1 7 KEGG: 00983+1.1.1.205;MetaCyc: PWY-6596;MetaCyc: PWY-5695;MetaCyc: PWY-7221;Reactome: R-HSA-6798695;Reactome: R-HSA-73817;KEGG: 00230+1.1.1.205 "Drug metabolism - other enzymes";"Adenosine nucleotides degradation I";"Inosine 5'-phosphate degradation";"Guanosine ribonucleotides de novo biosynthesis";"Neutrophil degranulation";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism" XP_046747919.1 26 Reactome: R-HSA-201722;Reactome: R-HSA-2644606;Reactome: R-HSA-1912408;Reactome: R-HSA-2894862;Reactome: R-HSA-3371568;Reactome: R-HSA-9617629;Reactome: R-HSA-3134973;Reactome: R-HSA-8866907;Reactome: R-HSA-8941856;Reactome: R-HSA-210744;Reactome: R-HSA-933541;Reactome: R-HSA-1368082;Reactome: R-HSA-3899300;Reactome: R-HSA-3214847;Reactome: R-HSA-1234158;Reactome: R-HSA-918233;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-9614657;Reactome: R-HSA-2122947;Reactome: R-HSA-5621575;Reactome: R-HSA-9013508;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-9013695;Reactome: R-HSA-5617472 "Formation of the beta-catenin:TCF transactivating complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Attenuation phase";"Regulation of FOXO transcriptional activity by acetylation";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Activation of the TFAP2 (AP-2) family of transcription factors";"RUNX3 regulates NOTCH signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"TRAF6 mediated IRF7 activation";"RORA activates gene expression";"SUMOylation of transcription cofactors";"HATs acetylate histones";"Regulation of gene expression by Hypoxia-inducible Factor";"TRAF3-dependent IRF activation pathway";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"FOXO-mediated transcription of cell death genes";"NOTCH1 Intracellular Domain Regulates Transcription";"CD209 (DC-SIGN) signaling";"NOTCH3 Intracellular Domain Regulates Transcription";"PPARA activates gene expression";"Estrogen-dependent gene expression";"NOTCH4 Intracellular Domain Regulates Transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis" XP_046753645.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046752825.1 5 Reactome: R-HSA-5673000;Reactome: R-HSA-9649948;Reactome: R-HSA-5675221;Reactome: R-HSA-6802946;Reactome: R-HSA-6802955 "RAF activation";"Signaling downstream of RAS mutants";"Negative regulation of MAPK pathway";"Signaling by moderate kinase activity BRAF mutants";"Paradoxical activation of RAF signaling by kinase inactive BRAF" XP_046740283.1 3 KEGG: 00510+2.4.1.144;Reactome: R-HSA-975574;MetaCyc: PWY-7426 "N-Glycan biosynthesis";"Reactions specific to the hybrid N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)" XP_046748401.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046740875.1 1 Reactome: R-HSA-3299685 "Detoxification of Reactive Oxygen Species" XP_046748010.1 29 Reactome: R-HSA-113418;Reactome: R-HSA-5696400;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-167160;Reactome: R-HSA-6782210;Reactome: R-HSA-167161;Reactome: R-HSA-72086;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-73772;Reactome: R-HSA-167162;Reactome: R-HSA-112382;Reactome: R-HSA-6782135;Reactome: R-HSA-167158;Reactome: R-HSA-167246;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-6781827;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-73776;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-6796648;Reactome: R-HSA-674695 "Formation of the Early Elongation Complex";"Dual Incision in GG-NER";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HIV Transcription Initiation";"mRNA Capping";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"RNA Polymerase I Promoter Escape";"RNA Polymerase II HIV Promoter Escape";"Formation of RNA Pol II elongation complex";"Dual incision in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events" XP_046744905.1 1 Reactome: R-HSA-8856828 "Clathrin-mediated endocytosis" XP_046752080.1 14 MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6598;MetaCyc: PWY-7035 "Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis" XP_046751533.1 17 Reactome: R-HSA-674695;Reactome: R-HSA-6796648;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-167246;KEGG: 05235+3.1.3.16;Reactome: R-HSA-167158;Reactome: R-HSA-167243;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-167200;Reactome: R-HSA-167242;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-113418 "RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"Tat-mediated elongation of the HIV-1 transcript";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the Early Elongation Complex" XP_046736152.1 2 Reactome: R-HSA-3214858;Reactome: R-HSA-8939243 "RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" XP_046753601.1 4 MetaCyc: PWY-6963;Reactome: R-HSA-73621;KEGG: 00910+1.4.1.14;KEGG: 00250+1.4.1.14 "Ammonia assimilation cycle I";"Pyrimidine catabolism";"Nitrogen metabolism";"Alanine, aspartate and glutamate metabolism" XP_046735802.1 5 KEGG: 00510+2.4.1.142;KEGG: 00790+3.4.19.9;KEGG: 00513+2.4.1.142;Reactome: R-HSA-6798695;MetaCyc: PWY-2161B "N-Glycan biosynthesis";"Folate biosynthesis";"Various types of N-glycan biosynthesis";"Neutrophil degranulation";"Glutamate removal from folates" XP_046745539.1 4 Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-1268020 "Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial protein import" XP_046740487.1 1 Reactome: R-HSA-9639288 "Amino acids regulate mTORC1" XP_046753704.1 4 Reactome: R-HSA-5656169;Reactome: R-HSA-5656121;Reactome: R-HSA-110312;Reactome: R-HSA-5655862 "Termination of translesion DNA synthesis";"Translesion synthesis by POLI";"Translesion synthesis by REV1";"Translesion synthesis by POLK" XP_046742582.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046740316.1 2 Reactome: R-HSA-3214841;Reactome: R-HSA-8936459 "PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" XP_046751560.1 1 Reactome: R-HSA-611105 "Respiratory electron transport" XP_046733808.1 3 Reactome: R-HSA-6794361;Reactome: R-HSA-9609736;Reactome: R-HSA-212676 "Neurexins and neuroligins";"Assembly and cell surface presentation of NMDA receptors";"Dopamine Neurotransmitter Release Cycle" XP_046737297.1 1 Reactome: R-HSA-913709 "O-linked glycosylation of mucins" XP_046740555.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046736129.1 5 Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046740018.1 2 Reactome: R-HSA-6807878;Reactome: R-HSA-6811438 "COPI-mediated anterograde transport";"Intra-Golgi traffic" XP_046740103.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046736663.1 3 Reactome: R-HSA-1362409;KEGG: 00860+1.16.3.1;Reactome: R-HSA-1268020 "Mitochondrial iron-sulfur cluster biogenesis";"Porphyrin and chlorophyll metabolism";"Mitochondrial protein import" XP_046751140.1 19 Reactome: R-HSA-8957275;Reactome: R-HSA-3000471;Reactome: R-HSA-5686938;Reactome: R-HSA-8964026;Reactome: R-HSA-8964041;Reactome: R-HSA-202733;Reactome: R-HSA-8964038;Reactome: R-HSA-975634;Reactome: R-HSA-8963901;Reactome: R-HSA-8964046;Reactome: R-HSA-3000480;Reactome: R-HSA-8963888;Reactome: R-HSA-3000484;Reactome: R-HSA-8856825;Reactome: R-HSA-8866423;Reactome: R-HSA-432142;Reactome: R-HSA-3000497;Reactome: R-HSA-8856828;Reactome: R-HSA-381426 "Post-translational protein phosphorylation";"Scavenging by Class B Receptors";"Regulation of TLR by endogenous ligand";"Chylomicron clearance";"LDL remodeling";"Cell surface interactions at the vascular wall";"LDL clearance";"Retinoid metabolism and transport";"Chylomicron remodeling";"VLDL clearance";"Scavenging by Class A Receptors";"Chylomicron assembly";"Scavenging by Class F Receptors";"Cargo recognition for clathrin-mediated endocytosis";"VLDL assembly";"Platelet sensitization by LDL";"Scavenging by Class H Receptors";"Clathrin-mediated endocytosis";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" XP_046741091.1 3 Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046747149.1 1 Reactome: R-HSA-3214847 "HATs acetylate histones" XP_046735752.1 2 Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28 "Digestion of dietary carbohydrate";"Starch and sucrose metabolism" XP_046735833.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane" XP_046743654.1 2 Reactome: R-HSA-611105;Reactome: R-HSA-6799198 "Respiratory electron transport";"Complex I biogenesis" XP_046734230.1 2 MetaCyc: PWY-5386;KEGG: 00620+3.1.2.6 "Methylglyoxal degradation I";"Pyruvate metabolism" XP_046743324.1 11 Reactome: R-HSA-5693554;Reactome: R-HSA-5358606;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-5358565;Reactome: R-HSA-5693616;Reactome: R-HSA-5685942;Reactome: R-HSA-69473;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579 "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)";"G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange" XP_046747732.1 3 Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236 "RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046749307.1 3 Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-159230 "RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"Transport of the SLBP Dependant Mature mRNA" XP_046735286.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046753457.1 5 Reactome: R-HSA-5610787;Reactome: R-HSA-5635838;Reactome: R-HSA-5632684;Reactome: R-HSA-373080;Reactome: R-HSA-5620922 "Hedgehog 'off' state";"Activation of SMO";"Hedgehog 'on' state";"Class B/2 (Secretin family receptors)";"BBSome-mediated cargo-targeting to cilium" XP_046752578.1 1 Reactome: R-HSA-6814848 "Glycerophospholipid catabolism" XP_046733990.1 1 Reactome: R-HSA-71288 "Creatine metabolism" XP_046748391.1 27 Reactome: R-HSA-5619107;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-1169408;Reactome: R-HSA-159230;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-3108214;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-168271;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-165054 "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"ISG15 antiviral mechanism";"Transport of the SLBP Dependant Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins";"HCMV Late Events";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA" XP_046737111.1 2 KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557 "T cell receptor signaling pathway";"Signaling by SCF-KIT" XP_046752688.1 10 MetaCyc: PWY-7112;KEGG: 00430+2.3.2.2;MetaCyc: PWY-6842;MetaCyc: PWY-7559;MetaCyc: PWY-4061;MetaCyc: PWY-4041;MetaCyc: PWY-8001;KEGG: 00460+2.3.2.2;MetaCyc: PWY-5826;KEGG: 00480+2.3.2.2+3.4.19.13 "4-hydroxy-2-nonenal detoxification";"Taurine and hypotaurine metabolism";"Glutathione-mediated detoxification II";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification I";"Gamma-glutamyl cycle";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Cyanoamino acid metabolism";"Hypoglycin biosynthesis";"Glutathione metabolism" XP_046739532.1 2 MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046745603.1 6 Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444 "Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" XP_046750751.1 3 Reactome: R-HSA-110357;Reactome: R-HSA-110330;Reactome: R-HSA-110331 "Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected purine";"Cleavage of the damaged purine" XP_046742445.1 3 MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361 "S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I" XP_046736305.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046738934.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046735783.1 2 Reactome: R-HSA-975957;Reactome: R-HSA-9010553 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs" XP_046739999.1 7 MetaCyc: PWY-6277;KEGG: 00230+2.4.2.14;KEGG: 00250+2.4.2.14;MetaCyc: PWY-6122;MetaCyc: PWY-7282;MetaCyc: PWY-6121;Reactome: R-HSA-73817 "Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine metabolism";"Alanine, aspartate and glutamate metabolism";"5-aminoimidazole ribonucleotide biosynthesis II";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis" XP_046745526.1 25 Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-437239;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-6811436;Reactome: R-HSA-9619483;Reactome: R-HSA-380270;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9646399;Reactome: R-HSA-1445148 "HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"RHO GTPases activate IQGAPs";"Cilium Assembly";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"Recycling pathway of L1";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport";"Kinesins";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-independent Golgi-to-ER retrograde traffic";"Activation of AMPK downstream of NMDARs";"Recruitment of mitotic centrosome proteins and complexes";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Aggrephagy";"Translocation of SLC2A4 (GLUT4) to the plasma membrane" XP_046751210.1 16 Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902 "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation" XP_046735060.1 17 Reactome: R-HSA-176407;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-141430;Reactome: R-HSA-8853884;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-179409;Reactome: R-HSA-2559582;Reactome: R-HSA-983168;Reactome: R-HSA-174048;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-174184;Reactome: R-HSA-176409;Reactome: R-HSA-176408 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Transcriptional Regulation by VENTX";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC-Cdc20 mediated degradation of Nek2A";"Senescence-Associated Secretory Phenotype (SASP)";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Cyclin B";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Regulation of APC/C activators between G1/S and early anaphase" XP_046739128.1 6 Reactome: R-HSA-72163;Reactome: R-HSA-975957;Reactome: R-HSA-72187;Reactome: R-HSA-9010553;Reactome: R-HSA-73856;Reactome: R-HSA-159236 "mRNA Splicing - Major Pathway";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA 3'-end processing";"Regulation of expression of SLITs and ROBOs";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript" XP_046746605.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046737638.1 1 Reactome: R-HSA-8876198 "RAB GEFs exchange GTP for GDP on RABs" XP_046738484.1 1 Reactome: R-HSA-2132295 "MHC class II antigen presentation" XP_046741568.1 2 Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15 "Detoxification of Reactive Oxygen Species";"Glutathione metabolism" XP_046751888.1 1 Reactome: R-HSA-189085 "Digestion of dietary carbohydrate" XP_046741062.1 11 Reactome: R-HSA-167152;Reactome: R-HSA-167238;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167200;Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-167243;Reactome: R-HSA-167246 "Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of Tat-mediated HIV elongation";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript" XP_046744111.1 11 Reactome: R-HSA-418555;Reactome: R-HSA-170670;Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-432040;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660 "G alpha (s) signalling events";"Adenylate cyclase inhibitory pathway";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"Hedgehog 'off' state";"PKA activation";"G alpha (z) signalling events";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Purine metabolism";"Adenylate cyclase activating pathway" XP_046740799.1 11 Reactome: R-HSA-212436;Reactome: R-HSA-400253;Reactome: R-HSA-381340;Reactome: R-HSA-1368082;Reactome: R-HSA-2151201;Reactome: R-HSA-383280;Reactome: R-HSA-1368108;Reactome: R-HSA-400206;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-2426168 "Generic Transcription Pathway";"Circadian Clock";"Transcriptional regulation of white adipocyte differentiation";"RORA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"Nuclear Receptor transcription pathway";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression";"Estrogen-dependent gene expression";"Activation of gene expression by SREBF (SREBP)" XP_046749666.1 5 Reactome: R-HSA-111457;Reactome: R-HSA-111469;Reactome: R-HSA-9627069;Reactome: R-HSA-111464;Reactome: R-HSA-111463 "Release of apoptotic factors from the mitochondria";"SMAC, XIAP-regulated apoptotic response";"Regulation of the apoptosome activity";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"SMAC (DIABLO) binds to IAPs" XP_046735873.1 1 Reactome: R-HSA-6782315 "tRNA modification in the nucleus and cytosol" XP_046735727.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046752290.1 2 Reactome: R-HSA-8856825;Reactome: R-HSA-8856828 "Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis" XP_046750456.1 1 Reactome: R-HSA-983168 "Antigen processing: Ubiquitination & Proteasome degradation" XP_046746581.1 3 Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261 "Triglyceride biosynthesis";"Glycerolipid metabolism";"Glycerol degradation I" XP_046741676.1 3 Reactome: R-HSA-6783310;MetaCyc: PWY-7511;Reactome: R-HSA-983168 "Fanconi Anemia Pathway";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation" XP_046744015.1 1 Reactome: R-HSA-6783310 "Fanconi Anemia Pathway" XP_046736480.1 2 Reactome: R-HSA-1236394;Reactome: R-HSA-977443 "Signaling by ERBB4";"GABA receptor activation" XP_046743447.1 11 Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-8854518;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380270 "Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"AURKA Activation by TPX2";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes" XP_046738716.1 1 Reactome: R-HSA-70221 "Glycogen breakdown (glycogenolysis)" XP_046751995.1 5 Reactome: R-HSA-5205685;Reactome: R-HSA-209560;Reactome: R-HSA-9020702;Reactome: R-HSA-205043;Reactome: R-HSA-209543 "Pink/Parkin Mediated Mitophagy";"NF-kB is activated and signals survival";"Interleukin-1 signaling";"NRIF signals cell death from the nucleus";"p75NTR recruits signalling complexes" XP_046751026.1 1 Reactome: R-HSA-189200 "Cellular hexose transport" XP_046747509.1 5 MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109 "Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis" XP_046740947.1 12 Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-73980;Reactome: R-HSA-73762;Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-427413;Reactome: R-HSA-73772;Reactome: R-HSA-749476;Reactome: R-HSA-5250924;Reactome: R-HSA-1834949;Reactome: R-HSA-73863 "RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase I Transcription Initiation";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase III Abortive And Retractive Initiation";"B-WICH complex positively regulates rRNA expression";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase I Transcription Termination" XP_046738829.1 56 Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-68949;Reactome: R-HSA-174084;Reactome: R-HSA-450408;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-174154;Reactome: R-HSA-382556;Reactome: R-HSA-8939902;Reactome: R-HSA-5678895;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553;Reactome: R-HSA-174184;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-5607764;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-1236974;Reactome: R-HSA-4608870;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-5358346;Reactome: R-HSA-75815;Reactome: R-HSA-68827;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8852276;Reactome: R-HSA-5362768;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-202424;Reactome: R-HSA-4641258;Reactome: R-HSA-69601;Reactome: R-HSA-180585;Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-69017 "Degradation of AXIN";"Neddylation";"Orc1 removal from chromatin";"Autodegradation of Cdh1 by Cdh1:APC/C";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdc20 mediated degradation of Securin";"ABC-family proteins mediated transport";"Regulation of RUNX2 expression and activity";"Defective CFTR causes cystic fibrosis";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"CLEC7A (Dectin-1) signaling";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"ER-Phagosome pathway";"Asymmetric localization of PCP proteins";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog ligand biogenesis";"Ubiquitin-dependent degradation of Cyclin D";"CDT1 association with the CDC6:ORC:origin complex";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Downstream TCR signaling";"Degradation of DVL";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Vif-mediated degradation of APOBEC3G";"NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"CDK-mediated phosphorylation and removal of Cdc6" XP_046736835.1 1 Reactome: R-HSA-5620924 "Intraflagellar transport" XP_046741458.1 42 Reactome: R-HSA-3214847;Reactome: R-HSA-5693571;Reactome: R-HSA-3214815;Reactome: R-HSA-5334118;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-2299718;Reactome: R-HSA-171306;Reactome: R-HSA-110328;Reactome: R-HSA-212300;Reactome: R-HSA-9018519;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-5625886;Reactome: R-HSA-73728;Reactome: R-HSA-69473;Reactome: R-HSA-9609690;Reactome: R-HSA-110330;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-73772;Reactome: R-HSA-5693565;Reactome: R-HSA-4551638;Reactome: R-HSA-3214842;Reactome: R-HSA-427413;Reactome: R-HSA-2559582;Reactome: R-HSA-2559580;Reactome: R-HSA-5578749;Reactome: R-HSA-5617472;Reactome: R-HSA-2559586;Reactome: R-HSA-1912408;Reactome: R-HSA-8936459;Reactome: R-HSA-3214858;Reactome: R-HSA-1221632;Reactome: R-HSA-427359;Reactome: R-HSA-9610379;Reactome: R-HSA-977225;Reactome: R-HSA-9616222;Reactome: R-HSA-8939236;Reactome: R-HSA-606279 "HATs acetylate histones";"Nonhomologous End-Joining (NHEJ)";"HDACs deacetylate histones";"DNA methylation";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Condensation of Prophase Chromosomes";"Packaging Of Telomere Ends";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"PRC2 methylates histones and DNA";"Estrogen-dependent gene expression";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"RNA Polymerase I Promoter Opening";"G2/M DNA damage checkpoint";"HCMV Early Events";"Recognition and association of DNA glycosylase with site containing an affected purine";"Processing of DNA double-strand break ends";"Meiotic recombination";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Promoter Escape";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"SUMOylation of chromatin organization proteins";"HDMs demethylate histones";"NoRC negatively regulates rRNA expression";"Senescence-Associated Secretory Phenotype (SASP)";"Oxidative Stress Induced Senescence";"Transcriptional regulation by small RNAs";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"DNA Damage/Telomere Stress Induced Senescence";"Pre-NOTCH Transcription and Translation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RMTs methylate histone arginines";"Meiotic synapsis";"SIRT1 negatively regulates rRNA expression";"HCMV Late Events";"Amyloid fiber formation";"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere" XP_046745816.1 1 Reactome: R-HSA-983231 "Factors involved in megakaryocyte development and platelet production" XP_046734002.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046736768.1 15 Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-5358747;Reactome: R-HSA-5358749;Reactome: R-HSA-5467348;Reactome: R-HSA-5358752;Reactome: R-HSA-4641262;Reactome: R-HSA-5358751;Reactome: R-HSA-5467340;Reactome: R-HSA-195253;Reactome: R-HSA-111465;Reactome: R-HSA-3769402;Reactome: R-HSA-5339716;Reactome: R-HSA-5689896;Reactome: R-HSA-5467333 "Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"S33 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S45 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"Degradation of beta-catenin by the destruction complex";"Apoptotic cleavage of cellular proteins";"Deactivation of the beta-catenin transactivating complex";"Misspliced GSK3beta mutants stabilize beta-catenin";"Ovarian tumor domain proteases";"APC truncation mutants are not K63 polyubiquitinated" XP_046749825.1 2 Reactome: R-HSA-416476;Reactome: R-HSA-388479 "G alpha (q) signalling events";"Vasopressin-like receptors" XP_046738747.1 1 Reactome: R-HSA-5576886 "Phase 4 - resting membrane potential" XP_046753181.1 5 Reactome: R-HSA-446210;MetaCyc: PWY-6749;MetaCyc: PWY-8013;KEGG: 00250+2.6.1.16;KEGG: 00520+2.6.1.16 "Synthesis of UDP-N-acetyl-glucosamine";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Amino sugar and nucleotide sugar metabolism" XP_046733899.1 8 Reactome: R-HSA-8866652;Reactome: R-HSA-6804757;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-5689880;Reactome: R-HSA-8948747;Reactome: R-HSA-6782210 "Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Regulation of TP53 Degradation";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Ub-specific processing proteases";"Regulation of PTEN localization";"Gap-filling DNA repair synthesis and ligation in TC-NER" XP_046743554.1 2 Reactome: R-HSA-6790901;Reactome: R-HSA-6791226 "rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol" XP_046746223.1 1 Reactome: R-HSA-432720 "Lysosome Vesicle Biogenesis" XP_046745357.1 2 Reactome: R-HSA-5576894;Reactome: R-HSA-1296072 "Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels" XP_046746045.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046746758.1 1 Reactome: R-HSA-3214858 "RMTs methylate histone arginines" XP_046742563.1 2 MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222 "Psilocybin biosynthesis";"Indole alkaloid biosynthesis" XP_046742565.1 12 Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-429947;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-166208;Reactome: R-HSA-72662;Reactome: R-HSA-1169408;Reactome: R-HSA-450408 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Deadenylation of mRNA";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"mTORC1-mediated signalling";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"ISG15 antiviral mechanism";"AUF1 (hnRNP D0) binds and destabilizes mRNA" XP_046735440.1 2 Reactome: R-HSA-6791226;Reactome: R-HSA-6790901 "Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol" XP_046745748.1 1 Reactome: R-HSA-264876 "Insulin processing" XP_046740617.1 1 Reactome: R-HSA-429947 "Deadenylation of mRNA" XP_046748389.1 27 Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-159230;Reactome: R-HSA-1169408;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-4615885;Reactome: R-HSA-9610379;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-168276;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-168271 "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA replication proteins";"HCMV Late Events";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"NS1 Mediated Effects on Host Pathways";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"Transport of Ribonucleoproteins into the Host Nucleus" XP_046753682.1 2 Reactome: R-HSA-5689603;Reactome: R-HSA-5696394 "UCH proteinases";"DNA Damage Recognition in GG-NER" XP_046736870.1 1 Reactome: R-HSA-2672351 "Stimuli-sensing channels" XP_046748193.1 2 Reactome: R-HSA-5339700;Reactome: R-HSA-4641265 "TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes" XP_046741153.1 6 KEGG: 04070+2.7.11.13;Reactome: R-HSA-76005;Reactome: R-HSA-5099900;Reactome: R-HSA-418597;Reactome: R-HSA-114516;Reactome: R-HSA-416993 "Phosphatidylinositol signaling system";"Response to elevated platelet cytosolic Ca2+";"WNT5A-dependent internalization of FZD4";"G alpha (z) signalling events";"Disinhibition of SNARE formation";"Trafficking of GluR2-containing AMPA receptors" XP_046749288.1 1 Reactome: R-HSA-3214841 "PKMTs methylate histone lysines" XP_046741461.1 1 KEGG: 00480+3.4.11.2 "Glutathione metabolism" XP_046746104.1 2 Reactome: R-HSA-6811434;Reactome: R-HSA-983189 "COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins" XP_046733908.1 1 Reactome: R-HSA-6811440 "Retrograde transport at the Trans-Golgi-Network" XP_046740098.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046742452.1 1 Reactome: R-HSA-432047 "Passive transport by Aquaporins" XP_046753280.1 2 Reactome: R-HSA-9033500;Reactome: R-HSA-9033241 "TYSND1 cleaves peroxisomal proteins";"Peroxisomal protein import" XP_046754061.1 4 Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-8856828;Reactome: R-HSA-5663213 "Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis";"RHO GTPases Activate WASPs and WAVEs" XP_046745422.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046748366.1 1 Reactome: R-HSA-5669034 "TNFs bind their physiological receptors" XP_046733787.1 2 Reactome: R-HSA-168138;Reactome: R-HSA-983231 "Toll Like Receptor 9 (TLR9) Cascade";"Factors involved in megakaryocyte development and platelet production" XP_046745419.1 1 Reactome: R-HSA-156588 "Glucuronidation" XP_046753935.1 3 Reactome: R-HSA-6798695;Reactome: R-HSA-2206291;Reactome: R-HSA-2024096 "Neutrophil degranulation";"MPS IIIC - Sanfilippo syndrome C";"HS-GAG degradation" XP_046745974.1 1 Reactome: R-HSA-3214842 "HDMs demethylate histones" XP_046740939.1 11 Reactome: R-HSA-5651801;Reactome: R-HSA-6782210;Reactome: R-HSA-68962;Reactome: R-HSA-5696397;Reactome: R-HSA-174430;Reactome: R-HSA-5656169;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-68952;Reactome: R-HSA-5685942;Reactome: R-HSA-110314 "PCNA-Dependent Long Patch Base Excision Repair";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Activation of the pre-replicative complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Telomere C-strand synthesis initiation";"Termination of translesion DNA synthesis";"Dual Incision in GG-NER";"Dual incision in TC-NER";"DNA replication initiation";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex" XP_046737408.1 3 Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-9018519 "PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression" XP_046751531.1 1 MetaCyc: PWY-7799 "Arg/N-end rule pathway (eukaryotic)" XP_046739020.1 1 Reactome: R-HSA-5610787 "Hedgehog 'off' state" XP_046744318.1 1 Reactome: R-HSA-975957 "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" XP_046738127.1 2 Reactome: R-HSA-416993;Reactome: R-HSA-202733 "Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall" XP_046737756.1 7 Reactome: R-HSA-201681;Reactome: R-HSA-4641262;Reactome: R-HSA-5663220;Reactome: R-HSA-5368598;Reactome: R-HSA-201688;Reactome: R-HSA-4641258;Reactome: R-HSA-4086400 "TCF dependent signaling in response to WNT";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RHO GTPases Activate Formins";"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"WNT mediated activation of DVL";"Degradation of DVL";"PCP/CE pathway" XP_046743728.1 33 Reactome: R-HSA-168276;Reactome: R-HSA-9609690;Reactome: R-HSA-168333;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-9648025;Reactome: R-HSA-159227;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-191859;Reactome: R-HSA-1169408;Reactome: R-HSA-68877;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-159231;Reactome: R-HSA-2500257;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-9610379;Reactome: R-HSA-4615885;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-141444;Reactome: R-HSA-159230;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-5663220;Reactome: R-HSA-5578749 "NS1 Mediated Effects on Host Pathways";"HCMV Early Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"EML4 and NUDC in mitotic spindle formation";"Transport of the SLBP independent Mature mRNA";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"snRNP Assembly";"ISG15 antiviral mechanism";"Mitotic Prometaphase";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transport of Mature mRNA Derived from an Intronless Transcript";"Resolution of Sister Chromatid Cohesion";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Late Events";"SUMOylation of DNA replication proteins";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of the SLBP Dependant Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"RHO GTPases Activate Formins";"Transcriptional regulation by small RNAs" XP_046745498.1 2 Reactome: R-HSA-380320;Reactome: R-HSA-380270 "Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes" XP_046747119.1 1 KEGG: 00970+6.1.1.16 "Aminoacyl-tRNA biosynthesis" XP_046753878.1 1 Reactome: R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" XP_046739717.1 31 Reactome: R-HSA-163765;MetaCyc: PWY-5366;MetaCyc: PWY-7746;MetaCyc: PWY-5994;MetaCyc: PWY-7723;Reactome: R-HSA-199220;Reactome: R-HSA-9029558;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWY-7858;MetaCyc: PWY-5147;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-2426168;MetaCyc: PWY-7663;MetaCyc: PWY-6113;Reactome: R-HSA-75105;MetaCyc: PWY-5971;MetaCyc: PWY-7664;MetaCyc: PWY-5367;MetaCyc: PWY-7388;MetaCyc: PWY-6799;MetaCyc: PWY-5973;MetaCyc: PWY-4381;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5966-1;MetaCyc: PWY-6282;MetaCyc: PWY-5989;MetaCyc: PWYG-321;MetaCyc: PWY-5142;MetaCyc: PWY-8047;MetaCyc: PWY-6519 "ChREBP activates metabolic gene expression";"Palmitoleate biosynthesis II (plants and bacteria)";"Mycobacterial sulfolipid biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Bacterial bioluminescence";"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Mupirocin biosynthesis";"Pederin biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Oleate biosynthesis I (plants)";"Biotin metabolism";"Activation of gene expression by SREBF (SREBP)";"Gondoate biosynthesis (anaerobic)";"Superpathway of mycolate biosynthesis";"Fatty acyl-CoA biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis IV (anaerobic)";"Petroselinate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Stearate biosynthesis II (bacteria and plants)";"";"Acyl-[acyl-carrier protein] thioesterase pathway";"Bryostatin biosynthesis";"8-amino-7-oxononanoate biosynthesis I" XP_046740788.1 2 KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1 "Pentose phosphate pathway";"Purine metabolism" XP_046744114.1 18 Reactome: R-HSA-5362517;Reactome: R-HSA-70268;Reactome: R-HSA-389661;Reactome: R-HSA-70895;KEGG: 00640+1.8.1.4;KEGG: 00010+1.8.1.4;Reactome: R-HSA-204174;MetaCyc: PWY-5084;KEGG: 00260+1.8.1.4;Reactome: R-HSA-71403;KEGG: 00620+1.8.1.4;MetaCyc: PWY-5046;Reactome: R-HSA-6783984;KEGG: 00280+1.8.1.4;KEGG: 00310+1.8.1.4;KEGG: 00020+1.8.1.4;Reactome: R-HSA-71064;KEGG: 00380+1.8.1.4 "Signaling by Retinoic Acid";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Branched-chain amino acid catabolism";"Propanoate metabolism";"Glycolysis / Gluconeogenesis";"Regulation of pyruvate dehydrogenase (PDH) complex";"2-oxoglutarate decarboxylation to succinyl-CoA";"Glycine, serine and threonine metabolism";"Citric acid cycle (TCA cycle)";"Pyruvate metabolism";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Glycine degradation";"Valine, leucine and isoleucine degradation";"Lysine degradation";"Citrate cycle (TCA cycle)";"Lysine catabolism";"Tryptophan metabolism" XP_046742690.1 1 Reactome: R-HSA-6804754 "Regulation of TP53 Expression" XP_046739646.1 3 Reactome: R-HSA-8963901;Reactome: R-HSA-445095;Reactome: R-HSA-6807878 "Chylomicron remodeling";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport" XP_046750559.1 1 Reactome: R-HSA-6807505 "RNA polymerase II transcribes snRNA genes" XP_046746763.1 3 MetaCyc: PWY-6700;MetaCyc: PWY-8106;Reactome: R-HSA-6782315 "Queuosine biosynthesis I (de novo)";"Queuosine biosynthesis III (queuosine salvage)";"tRNA modification in the nucleus and cytosol" XP_046743590.1 7 MetaCyc: PWY-7511;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2979096;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606 "Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants" XP_046745263.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046752358.1 2 Reactome: R-HSA-444821;Reactome: R-HSA-418555 "Relaxin receptors";"G alpha (s) signalling events" XP_046750393.1 7 KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1 "Human papillomavirus infection";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection" XP_046743478.1 3 Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876 "Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing" XP_046739461.1 1 Reactome: R-HSA-2468052 "Establishment of Sister Chromatid Cohesion" XP_046743529.1 2 Reactome: R-HSA-5628897;Reactome: R-HSA-611105 "TP53 Regulates Metabolic Genes";"Respiratory electron transport" XP_046739535.1 2 Reactome: R-HSA-983168;MetaCyc: PWY-7511 "Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination" XP_046735630.1 1 Reactome: R-HSA-6791226 "Major pathway of rRNA processing in the nucleolus and cytosol" XP_046743388.1 18 KEGG: 00400+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00270+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00360+2.6.1.1;MetaCyc: PWY-6638;MetaCyc: PWY-7383;MetaCyc: PWY-7117;MetaCyc: PWY-6642;KEGG: 00330+2.6.1.1;KEGG: 00960+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00950+2.6.1.1;KEGG: 00350+2.6.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-5913 "Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine biosynthesis";"Cysteine and methionine metabolism";"Alanine, aspartate and glutamate metabolism";"Novobiocin biosynthesis";"Carbon fixation in photosynthetic organisms";"Phenylalanine metabolism";"Sulfolactate degradation III";"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"(R)-cysteate degradation";"Arginine and proline metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Coenzyme M biosynthesis II";"Isoquinoline alkaloid biosynthesis";"Tyrosine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Partial TCA cycle (obligate autotrophs)" XP_046750222.1 1 Reactome: R-HSA-1799339 "SRP-dependent cotranslational protein targeting to membrane"