Accession_ID	Pathway_Count	Pathway_IDs	Pathway_Names
Mdes015087-RA	12	MetaCyc: PWY-5690;MetaCyc: PWY-6728;KEGG: 00640+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5538;MetaCyc: PWY-5913;KEGG: 00720+6.2.1.5;MetaCyc: PWY-6969;MetaCyc: PWY-7384;MetaCyc: PWY-5392;MetaCyc: PWY-5537;KEGG: 00020+6.2.1.5	"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"Pyruvate fermentation to acetate VI";"Partial TCA cycle (obligate autotrophs)";"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Reductive TCA cycle II";"Pyruvate fermentation to acetate V";"Citrate cycle (TCA cycle)"
Mdes015871-RA	3	KEGG: 00970+6.1.1.4;Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
Mdes006898-RB	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
Mdes010200-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes007771-RA	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
Mdes009026-RB	4	Reactome: R-HSA-3928662;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-8856828	"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"Clathrin-mediated endocytosis"
Mdes008807-RA	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
Mdes017178-RA	6	Reactome: R-HSA-9033241;Reactome: R-HSA-6798695;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;KEGG: 00630+1.11.1.6;Reactome: R-HSA-3299685	"Peroxisomal protein import";"Neutrophil degranulation";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Glyoxylate and dicarboxylate metabolism";"Detoxification of Reactive Oxygen Species"
Mdes001889-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes006866-RA	24	Reactome: R-HSA-442720;Reactome: R-HSA-111931;Reactome: R-HSA-4420097;Reactome: R-HSA-164378;Reactome: R-HSA-422356;KEGG: 04150+2.7.11.11;Reactome: R-HSA-381676;Reactome: R-HSA-180024;Reactome: R-HSA-5687128;Reactome: R-HSA-5610780;Reactome: R-HSA-163560;Reactome: R-HSA-392517;Reactome: R-HSA-8963896;Reactome: R-HSA-163358;Reactome: R-HSA-163615;Reactome: R-HSA-5621575;Reactome: R-HSA-5610785;Reactome: R-HSA-8853659;Reactome: R-HSA-5610783;Reactome: R-HSA-983231;Reactome: R-HSA-9010642;Reactome: R-HSA-5610787;Reactome: R-HSA-432040;Reactome: R-HSA-9634600	"CREB1 phosphorylation through the activation of Adenylate Cyclase";"PKA-mediated phosphorylation of CREB";"VEGFA-VEGFR2 Pathway";"PKA activation in glucagon signalling";"Regulation of insulin secretion";"mTOR signaling pathway";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"DARPP-32 events";"MAPK6/MAPK4 signaling";"Degradation of GLI1 by the proteasome";"Triglyceride catabolism";"Rap1 signalling";"HDL assembly";"PKA-mediated phosphorylation of key metabolic factors";"PKA activation";"CD209 (DC-SIGN) signaling";"GLI3 is processed to GLI3R by the proteasome";"RET signaling";"Degradation of GLI2 by the proteasome";"Factors involved in megakaryocyte development and platelet production";"ROBO receptors bind AKAP5";"Hedgehog 'off' state";"Vasopressin regulates renal water homeostasis via Aquaporins";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
Mdes018869-RA	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
Mdes014057-RB	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes017514-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes001997-RA	56	Reactome: R-HSA-187577;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-5689880;Reactome: R-HSA-5607764;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5668541;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-4641257;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5362768;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174113;Reactome: R-HSA-5610780	"SCF(Skp2)-mediated degradation of p27/p21";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"Ub-specific processing proteases";"CLEC7A (Dectin-1) signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"TNFR2 non-canonical NF-kB pathway";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Neddylation";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of AXIN";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome"
Mdes018046-RA	1	KEGG: 00290+4.2.1.33	"Valine, leucine and isoleucine biosynthesis"
Mdes001984-RA	3	Reactome: R-HSA-6784531;MetaCyc: PWY-7803;MetaCyc: PWY-6689	"tRNA processing in the nucleus";"Trna splicing II";"Trna splicing I"
Mdes008391-RA	7	Reactome: R-HSA-1632852;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-5628897	"Macroautophagy";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"TP53 Regulates Metabolic Genes"
Mdes010283-RB	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
Mdes004959-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Mdes018401-RA	8	MetaCyc: PWY-4984;KEGG: 00220+6.3.4.5;MetaCyc: PWY-4983;MetaCyc: PWY-7400;MetaCyc: PWY-5154;Reactome: R-HSA-70635;MetaCyc: PWY-5;KEGG: 00250+6.3.4.5	"Urea cycle";"Arginine biosynthesis";"Nitric oxide biosynthesis II (mammals)";"L-arginine biosynthesis IV (archaebacteria)";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Urea cycle";"Canavanine biosynthesis";"Alanine, aspartate and glutamate metabolism"
Mdes002293-RA	29	Reactome: R-HSA-2559586;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5693554;Reactome: R-HSA-6803204;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5693565;Reactome: R-HSA-69541;Reactome: R-HSA-5693616;Reactome: R-HSA-349425;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693568;Reactome: R-HSA-3371453;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938;Reactome: R-HSA-5693548;Reactome: R-HSA-6804760;Reactome: R-HSA-6804757;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-6804756;Reactome: R-HSA-6803207;Reactome: R-HSA-5693571;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-6796648;KEGG: 05165+2.7.11.1	"DNA Damage/Telomere Stress Induced Senescence";"Human cytomegalovirus infection";"Thermogenesis";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Stabilization of p53";"Presynaptic phase of homologous DNA pairing and strand exchange";"Autodegradation of the E3 ubiquitin ligase COP1";"Relaxin signaling pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Regulation of HSF1-mediated heat shock response";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)";"Sensing of DNA Double Strand Breaks";"Regulation of TP53 Activity through Methylation";"Regulation of TP53 Degradation";"mTOR signaling pathway";"Processing of DNA double-strand break ends";"Meiotic recombination";"Regulation of TP53 Activity through Phosphorylation";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Nonhomologous End-Joining (NHEJ)";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"TP53 Regulates Transcription of DNA Repair Genes";"Human papillomavirus infection"
Mdes004572-RA	2	Reactome: R-HSA-9610379;Reactome: R-HSA-917729	"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)"
Mdes001612-RA	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
Mdes002814-RA	2	MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis"
Mdes008162-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes006493-RA	6	Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450385	"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes003169-RA	3	MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21;Reactome: R-HSA-389661	"Mitochondrial L-carnitine shuttle";"Fatty acid degradation";"Glyoxylate metabolism and glycine degradation"
Mdes011210-RA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Mdes008873-RA	6	Reactome: R-HSA-6811434;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"Kinesins"
Mdes008796-RB	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes011152-RA	20	Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-166208;Reactome: R-HSA-3371571;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-389357;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-1257604;KEGG: 05165+2.7.11.1;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6804757;Reactome: R-HSA-1632852;Reactome: R-HSA-5218920;KEGG: 04926+2.7.11.1;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897	"Regulation of PTEN gene transcription";"mTOR signalling";"mTORC1-mediated signalling";"HSF1-dependent transactivation";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"CD28 dependent PI3K/Akt signaling";"Thermogenesis";"Human cytomegalovirus infection";"PIP3 activates AKT signaling";"Human papillomavirus infection";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"mTOR signaling pathway";"Regulation of TP53 Degradation";"Macroautophagy";"VEGFR2 mediated vascular permeability";"Relaxin signaling pathway";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes"
Mdes001383-RA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Mdes000454-RA	2	KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753	"Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism"
Mdes018915-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Mdes003751-RB	5	Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712	"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport"
Mdes017982-RA	3	KEGG: 00220+1.2.1.38;MetaCyc: PWY-7400;MetaCyc: PWY-5154	"Arginine biosynthesis";"L-arginine biosynthesis IV (archaebacteria)";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)"
Mdes001093-RB	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes003907-RA	8	MetaCyc: PWY-5514;Reactome: R-HSA-379716;MetaCyc: PWY-6906;Reactome: R-HSA-446210;KEGG: 00520+5.4.2.10;KEGG: 00520+5.4.2.3;MetaCyc: PWY-6749;KEGG: 00970+6.1.1.20	"UDP-N-acetyl-D-galactosamine biosynthesis II";"Cytosolic tRNA aminoacylation";"Chitin derivatives degradation";"Synthesis of UDP-N-acetyl-glucosamine";"Amino sugar and nucleotide sugar metabolism";"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I";"Aminoacyl-tRNA biosynthesis"
Mdes003753-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Mdes005707-RA	6	Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390471;Reactome: R-HSA-6814122;Reactome: R-HSA-5620922;Reactome: R-HSA-390450	"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"BBSome-mediated cargo-targeting to cilium";"Folding of actin by CCT/TriC"
Mdes001860-RA	1	Reactome: R-HSA-977347	"Serine biosynthesis"
Mdes002109-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes012339-RB	5	Reactome: R-HSA-2122947;Reactome: R-HSA-3214815;Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606	"NOTCH1 Intracellular Domain Regulates Transcription";"HDACs deacetylate histones";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
Mdes015450-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes017149-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes003242-RA	8	MetaCyc: PWY-7922;MetaCyc: PWY-7921;Reactome: R-HSA-5083629;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5173105;MetaCyc: PWY-7979;Reactome: R-HSA-5083633;KEGG: 00514+2.4.1.109	"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Mannose type O-glycan biosynthesis";"O-linked glycosylation";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Other types of O-glycan biosynthesis"
Mdes000421-RC	5	Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-73772;Reactome: R-HSA-73762	"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation"
Mdes000369-RA	12	MetaCyc: PWY-5856;MetaCyc: PWY-5870;MetaCyc: PWY-5871;MetaCyc: PWY-5873;Reactome: R-HSA-1268020;MetaCyc: PWY-5872;Reactome: R-HSA-2142789;MetaCyc: PWY-5855;MetaCyc: PWY-5857;KEGG: 00130+2.5.1.39;MetaCyc: PWY-6978;MetaCyc: PWY-6708	"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Mitochondrial protein import";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Plastoquinol-9 biosynthesis II";"Ubiquinol-8 biosynthesis (prokaryotic)"
Mdes017254-RA	2	Reactome: R-HSA-71240;KEGG: 00380+1.13.11.11	"Tryptophan catabolism";"Tryptophan metabolism"
Mdes011267-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes013599-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Mdes001435-RA	7	Reactome: R-HSA-5173105;Reactome: R-HSA-9010553;Reactome: R-HSA-3000178;Reactome: R-HSA-5083633;Reactome: R-HSA-5083629;Reactome: R-HSA-5083628;Reactome: R-HSA-3000171	"O-linked glycosylation";"Regulation of expression of SLITs and ROBOs";"ECM proteoglycans";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Non-integrin membrane-ECM interactions"
Mdes009321-RA	27	Reactome: R-HSA-4551638;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-159230;Reactome: R-HSA-3371453;Reactome: R-HSA-168333;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-180910;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-6784531;Reactome: R-HSA-168325	"SUMOylation of chromatin organization proteins";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP Dependant Mature mRNA";"Regulation of HSF1-mediated heat shock response";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Vpr-mediated nuclear import of PICs";"HCMV Late Events";"ISG15 antiviral mechanism";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis"
Mdes001514-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes018737-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Mdes003274-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes016767-RC	5	MetaCyc: PWY-7082;MetaCyc: PWY-7279;MetaCyc: PWY-3781;KEGG: 00190+7.1.1.8;MetaCyc: PWY-6692	"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration I (cytochrome c)";"Oxidative phosphorylation";"Fe(II) oxidation"
Mdes011916-RA	4	KEGG: 00230+6.3.4.4;Reactome: R-HSA-73817;KEGG: 00250+6.3.4.4;MetaCyc: PWY-7219	"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Alanine, aspartate and glutamate metabolism";"Adenosine ribonucleotides de novo biosynthesis"
Mdes009324-RA	5	Reactome: R-HSA-162588;Reactome: R-HSA-9610379;Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-917729	"Budding and maturation of HIV virion";"HCMV Late Events";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)"
Mdes003067-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes011203-RA	19	Reactome: R-HSA-3000484;Reactome: R-HSA-8964041;Reactome: R-HSA-381426;Reactome: R-HSA-8866423;Reactome: R-HSA-3000497;Reactome: R-HSA-8963888;Reactome: R-HSA-5686938;Reactome: R-HSA-3000480;Reactome: R-HSA-432142;Reactome: R-HSA-8964026;Reactome: R-HSA-202733;Reactome: R-HSA-8964038;Reactome: R-HSA-975634;Reactome: R-HSA-3000471;Reactome: R-HSA-8856825;Reactome: R-HSA-8964046;Reactome: R-HSA-8856828;Reactome: R-HSA-8963901;Reactome: R-HSA-8957275	"Scavenging by Class F Receptors";"LDL remodeling";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"VLDL assembly";"Scavenging by Class H Receptors";"Chylomicron assembly";"Regulation of TLR by endogenous ligand";"Scavenging by Class A Receptors";"Platelet sensitization by LDL";"Chylomicron clearance";"Cell surface interactions at the vascular wall";"LDL clearance";"Retinoid metabolism and transport";"Scavenging by Class B Receptors";"Cargo recognition for clathrin-mediated endocytosis";"VLDL clearance";"Clathrin-mediated endocytosis";"Chylomicron remodeling";"Post-translational protein phosphorylation"
Mdes005396-RC	3	KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00250+3.5.1.1	"Cyanoamino acid metabolism";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism"
Mdes017910-RA	4	Reactome: R-HSA-3214847;KEGG: 00514+2.4.1.255;Reactome: R-HSA-5689603;MetaCyc: PWY-7437	"HATs acetylate histones";"Other types of O-glycan biosynthesis";"UCH proteinases";"Protein O-[N-acetyl]-glucosylation"
Mdes014511-RA	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
Mdes005358-RB	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Mdes009999-RB	2	Reactome: R-HSA-5205685;Reactome: R-HSA-983231	"Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production"
Mdes004822-RA	6	KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656	"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis"
Mdes004696-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes006118-RF	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
Mdes008154-RA	14	MetaCyc: PWY-8053;Reactome: R-HSA-75109;KEGG: 00600+3.1.3.4;KEGG: 00561+3.1.3.4;KEGG: 00564+3.1.3.4;KEGG: 00565+3.1.3.4;Reactome: R-HSA-4419969;MetaCyc: PWY-7782;MetaCyc: PWY-8051;MetaCyc: PWY-6453;Reactome: R-HSA-1483213;MetaCyc: PWY-8052;Reactome: R-HSA-1483191;MetaCyc: PWY-8055	"Anandamide biosynthesis II";"Triglyceride biosynthesis";"Sphingolipid metabolism";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Depolymerisation of the Nuclear Lamina";"Plasmalogen biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Synthesis of PE";"2-arachidonoylglycerol biosynthesis";"Synthesis of PC";"Palmitoyl ethanolamide biosynthesis"
Mdes002333-RA	4	KEGG: 00510+2.4.1.257+2.4.1.132;Reactome: R-HSA-4549349;KEGG: 00513+2.4.1.257+2.4.1.132;Reactome: R-HSA-446193	"N-Glycan biosynthesis";"Defective ALG2 causes ALG2-CDG (CDG-1i)";"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
Mdes008262-RA	7	KEGG: 04070+3.1.3.25;Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.25;MetaCyc: PWY-4702;MetaCyc: PWY-2301;MetaCyc: PWY-6363;KEGG: 00521+3.1.3.25	"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Phytate degradation I";"Myo-inositol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Streptomycin biosynthesis"
Mdes001191-RA	19	Reactome: R-HSA-381426;Reactome: R-HSA-8964041;Reactome: R-HSA-8866423;Reactome: R-HSA-3000484;Reactome: R-HSA-432142;Reactome: R-HSA-3000480;Reactome: R-HSA-8964026;Reactome: R-HSA-5686938;Reactome: R-HSA-8963888;Reactome: R-HSA-3000497;Reactome: R-HSA-8964046;Reactome: R-HSA-3000471;Reactome: R-HSA-8856825;Reactome: R-HSA-8964038;Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-8957275;Reactome: R-HSA-8963901;Reactome: R-HSA-8856828	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"LDL remodeling";"VLDL assembly";"Scavenging by Class F Receptors";"Platelet sensitization by LDL";"Scavenging by Class A Receptors";"Chylomicron clearance";"Regulation of TLR by endogenous ligand";"Chylomicron assembly";"Scavenging by Class H Receptors";"VLDL clearance";"Scavenging by Class B Receptors";"Cargo recognition for clathrin-mediated endocytosis";"LDL clearance";"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"Post-translational protein phosphorylation";"Chylomicron remodeling";"Clathrin-mediated endocytosis"
Mdes004109-RB	3	KEGG: 00534+5.1.3.17;MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
Mdes004605-RA	1	Reactome: R-HSA-1483191	"Synthesis of PC"
Mdes000703-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Mdes002238-RC	13	Reactome: R-HSA-1650814;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-2214320;Reactome: R-HSA-3000171;Reactome: R-HSA-2243919;Reactome: R-HSA-3000157;Reactome: R-HSA-216083;Reactome: R-HSA-419037;Reactome: R-HSA-1474244;Reactome: R-HSA-3000178;Reactome: R-HSA-186797;Reactome: R-HSA-2022090	"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization";"Collagen degradation";"Anchoring fibril formation";"Non-integrin membrane-ECM interactions";"Crosslinking of collagen fibrils";"Laminin interactions";"Integrin cell surface interactions";"NCAM1 interactions";"Extracellular matrix organization";"ECM proteoglycans";"Signaling by PDGF";"Assembly of collagen fibrils and other multimeric structures"
Mdes007365-RA	2	Reactome: R-HSA-2564830;Reactome: R-HSA-5693554	"Cytosolic iron-sulfur cluster assembly";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
Mdes008408-RA	1	KEGG: 00970+6.1.1.22	"Aminoacyl-tRNA biosynthesis"
Mdes006109-RA	1	Reactome: R-HSA-419037	"NCAM1 interactions"
Mdes005275-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes000079-RC	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway"
Mdes010807-RA	1	Reactome: R-HSA-112308	"Presynaptic depolarization and calcium channel opening"
Mdes003690-RG	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Mdes012384-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Mdes010218-RD	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
Mdes000117-RB	4	Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes011374-RA	3	KEGG: 00510+2.4.1.265;Reactome: R-HSA-4724325;Reactome: R-HSA-446193	"N-Glycan biosynthesis";"Defective ALG8 causes ALG8-CDG (CDG-1h)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
Mdes005224-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes006125-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes003815-RA	19	MetaCyc: PWY-7115;MetaCyc: PWY-6728;KEGG: 00710+1.1.1.37;KEGG: 00680+1.1.1.37;KEGG: 00630+1.1.1.37;MetaCyc: PWY-8086;KEGG: 00020+1.1.1.37;KEGG: 00720+1.1.1.37;KEGG: 00620+1.1.1.37;MetaCyc: PWY-7383;MetaCyc: PWY-5913;MetaCyc: PWY-5690;Reactome: R-HSA-71403;MetaCyc: PWY-561;Reactome: R-HSA-70263;MetaCyc: PWY-1622;MetaCyc: PWY-5392;MetaCyc: PWY-6969;KEGG: 00270+1.1.1.37	"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Methylaspartate cycle";"Carbon fixation in photosynthetic organisms";"Methane metabolism";"Glyoxylate and dicarboxylate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Pyruvate metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Partial TCA cycle (obligate autotrophs)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Gluconeogenesis";"Formaldehyde assimilation I (serine pathway)";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Cysteine and methionine metabolism"
Mdes003306-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes012231-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes017629-RA	11	MetaCyc: PWY-6113;MetaCyc: PWY-5973;MetaCyc: PWY-6282;MetaCyc: PWY-7664;MetaCyc: PWY-6519;MetaCyc: PWY-5971;MetaCyc: PWY-7858;MetaCyc: PWYG-321;KEGG: 00061+1.3.1.9;MetaCyc: PWY-5989;MetaCyc: PWY-7663	"Superpathway of mycolate biosynthesis";"Cis-vaccenate biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Oleate biosynthesis IV (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"(5Z)-dodecenoate biosynthesis II";"";"Fatty acid biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Gondoate biosynthesis (anaerobic)"
Mdes000423-RA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
Mdes014146-RB	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
Mdes009825-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Mdes000217-RA	33	Reactome: R-HSA-427413;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-75955;Reactome: R-HSA-167162;Reactome: R-HSA-77075;Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-69202;Reactome: R-HSA-6781827;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-73762;Reactome: R-HSA-112382;Reactome: R-HSA-5696395;Reactome: R-HSA-69273;Reactome: R-HSA-113418;Reactome: R-HSA-6796648;Reactome: R-HSA-8939236;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-76042;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-69656;Reactome: R-HSA-69231;Reactome: R-HSA-73772;Reactome: R-HSA-674695;Reactome: R-HSA-6782135;Reactome: R-HSA-167161	"NoRC negatively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"Cyclin E associated events during G1/S transition";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"RNA Polymerase I Transcription Initiation";"Formation of RNA Pol II elongation complex";"Formation of Incision Complex in GG-NER";"Cyclin A/B1/B2 associated events during G2/M transition";"Formation of the Early Elongation Complex";"TP53 Regulates Transcription of DNA Repair Genes";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin D associated events in G1";"RNA Polymerase I Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Dual incision in TC-NER";"HIV Transcription Initiation"
Mdes016578-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes012371-RA	27	Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-168333;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-159230;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-3371453;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-4615885;Reactome: R-HSA-170822	"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein"
Mdes012882-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes006324-RA	1	Reactome: R-HSA-376172	"DSCAM interactions"
Mdes009206-RA	5	Reactome: R-HSA-159236;Reactome: R-HSA-72165;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes001130-RD	4	Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-9010553	"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
Mdes008053-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes013266-RA	6	MetaCyc: PWY-7234;MetaCyc: PWY-6123;KEGG: 00230+3.5.4.10+2.1.2.3;MetaCyc: PWY-6124;KEGG: 00670+2.1.2.3;Reactome: R-HSA-73817	"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Inosine-5'-phosphate biosynthesis II";"One carbon pool by folate";"Purine ribonucleoside monophosphate biosynthesis"
Mdes005168-RA	1	Reactome: R-HSA-427359	"SIRT1 negatively regulates rRNA expression"
Mdes018231-RA	6	MetaCyc: PWY-7111;MetaCyc: PWY-5103;KEGG: 00290+4.2.1.9;KEGG: 00770+4.2.1.9;MetaCyc: PWY-5104;MetaCyc: PWY-5101	"Pyruvate fermentation to isobutanol (engineered)";"L-isoleucine biosynthesis III";"Valine, leucine and isoleucine biosynthesis";"Pantothenate and CoA biosynthesis";"L-isoleucine biosynthesis IV";"L-isoleucine biosynthesis II"
Mdes012183-RA	5	Reactome: R-HSA-4755579;Reactome: R-HSA-193048;Reactome: R-HSA-446199;KEGG: 00510+1.3.1.94;MetaCyc: PWY-6129	"Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ";"Androgen biosynthesis";"Synthesis of Dolichyl-phosphate";"N-Glycan biosynthesis";"Dolichol and dolichyl phosphate biosynthesis"
Mdes016689-RA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
Mdes007029-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes009113-RA	18	Reactome: R-HSA-674695;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-77075;Reactome: R-HSA-167242;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167246	"RNA Polymerase II Pre-transcription Events";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"RNA Pol II CTD phosphorylation and interaction with CE";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript"
Mdes009836-RA	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
Mdes001404-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Mdes006168-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Mdes016525-RA	5	KEGG: 00400+2.5.1.54;MetaCyc: PWY-6164;KEGG: 00540+2.5.1.55;MetaCyc: PWY-1269;MetaCyc: PWY-7674	"Phenylalanine, tyrosine and tryptophan biosynthesis";"3-dehydroquinate biosynthesis I";"Lipopolysaccharide biosynthesis";"CMP-3-deoxy-D-manno-octulosonate biosynthesis";"CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis"
Mdes015568-RA	5	Reactome: R-HSA-901042;Reactome: R-HSA-381426;Reactome: R-HSA-532668;Reactome: R-HSA-879415;Reactome: R-HSA-8957275	"Calnexin/calreticulin cycle";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Advanced glycosylation endproduct receptor signaling";"Post-translational protein phosphorylation"
Mdes001675-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
Mdes009213-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes010980-RA	2	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network"
Mdes015998-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Mdes011566-RA	18	Reactome: R-HSA-1482839;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;MetaCyc: PWY-6803;Reactome: R-HSA-1482801;MetaCyc: PWY-7409;MetaCyc: PWY-8051;MetaCyc: PWY-7417;Reactome: R-HSA-1482922;MetaCyc: PWY-8053;Reactome: R-HSA-1482925;Reactome: R-HSA-1482788;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4	"Acyl chain remodelling of PE";"Arachidonic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Linoleic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PI";"Anandamide biosynthesis II";"Acyl chain remodelling of PG";"Acyl chain remodelling of PC";"Synthesis of PA";"Glycerophospholipid metabolism"
Mdes001228-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes014584-RA	14	Reactome: R-HSA-611105;MetaCyc: PWY-3781;MetaCyc: PWY-6969;MetaCyc: PWY-4302;MetaCyc: PWY-561;KEGG: 00720+1.3.5.1;MetaCyc: PWY-7279;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-5690;KEGG: 00650+1.3.5.1;MetaCyc: PWY-7254;KEGG: 00020+1.3.5.1;KEGG: 00190+1.3.5.1	"Respiratory electron transport";"Aerobic respiration I (cytochrome c)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Carbon fixation pathways in prokaryotes";"Aerobic respiration II (cytochrome c) (yeast)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Butanoate metabolism";"TCA cycle VII (acetate-producers)";"Citrate cycle (TCA cycle)";"Oxidative phosphorylation"
Mdes006568-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Mdes008646-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes015944-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes010935-RA	3	Reactome: R-HSA-111367;Reactome: R-HSA-73856;Reactome: R-HSA-77588	"SLBP independent Processing of Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"
Mdes015739-RA	7	Reactome: R-HSA-1660499;Reactome: R-HSA-1660516;MetaCyc: PWY-6351;MetaCyc: PWY-6352;Reactome: R-HSA-1660514;KEGG: 00562+2.7.1.67;KEGG: 04070+2.7.1.67	"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the early endosome membrane";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"3-phosphoinositide biosynthesis";"Synthesis of PIPs at the Golgi membrane";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system"
Mdes018069-RA	16	Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764	"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination"
Mdes004142-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes001784-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes007087-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Mdes016708-RA	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway"
Mdes013365-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-6798695	"Glycosphingolipid metabolism";"Neutrophil degranulation"
Mdes001931-RA	2	Reactome: R-HSA-6782315;MetaCyc: PWY-6829	"tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)"
Mdes004638-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes003127-RA	6	Reactome: R-HSA-5083632;MetaCyc: PWY-7433;MetaCyc: PWY-7290;Reactome: R-HSA-913709;KEGG: 00514+2.4.1.122;KEGG: 00512+2.4.1.122	"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Mucin core 1 and core 2 O-glycosylation";"Escherichia coli serotype O86 O-antigen biosynthesis";"O-linked glycosylation of mucins";"Other types of O-glycan biosynthesis";"Mucin type O-glycan biosynthesis"
Mdes010220-RA	2	Reactome: R-HSA-189451;Reactome: R-HSA-9609523	"Heme biosynthesis";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Mdes002640-RA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
Mdes016337-RA	10	Reactome: R-HSA-70171;MetaCyc: PWY-8004;MetaCyc: PWY-5484;MetaCyc: PWY-1042;KEGG: 00710+2.7.2.3;Reactome: R-HSA-70263;MetaCyc: PWY-7003;MetaCyc: PWY-6886;MetaCyc: PWY-6901;KEGG: 00010+2.7.2.3	"Glycolysis";"Entner-Doudoroff pathway I";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis";"Glycerol degradation to butanol";"1-butanol autotrophic biosynthesis (engineered)";"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis"
Mdes003810-RA	2	Reactome: R-HSA-389661;Reactome: R-HSA-2408508	"Glyoxylate metabolism and glycine degradation";"Metabolism of ingested SeMet, Sec, MeSec into H2Se"
Mdes003829-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes005336-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Mdes012281-RA	8	Reactome: R-HSA-8943724;Reactome: R-HSA-5617472;Reactome: R-HSA-9609690;Reactome: R-HSA-3214841;Reactome: R-HSA-212300;Reactome: R-HSA-2559580;Reactome: R-HSA-8953750;Reactome: R-HSA-4551638	"Regulation of PTEN gene transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HCMV Early Events";"PKMTs methylate histone lysines";"PRC2 methylates histones and DNA";"Oxidative Stress Induced Senescence";"Transcriptional Regulation by E2F6";"SUMOylation of chromatin organization proteins"
Mdes003792-RE	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
Mdes014870-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes001527-RA	1	Reactome: R-HSA-427601	"Multifunctional anion exchangers"
Mdes004409-RA	5	KEGG: 00534+2.4.1.224+2.4.1.225;MetaCyc: PWY-6558;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253	"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Heparan sulfate biosynthesis (late stages)";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS"
Mdes000230-RA	13	Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes013629-RA	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
Mdes014006-RB	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes014684-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes004891-RA	2	KEGG: 00260+2.3.1.29;Reactome: R-HSA-8849175	"Glycine, serine and threonine metabolism";"Threonine catabolism"
Mdes007476-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes015667-RA	57	Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5668541;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-5687128;Reactome: R-HSA-6798695;Reactome: R-HSA-450408;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-174154;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815	"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"TNFR2 non-canonical NF-kB pathway";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"MAPK6/MAPK4 signaling";"Neutrophil degranulation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdc20 mediated degradation of Securin";"Ub-specific processing proteases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D"
Mdes010588-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes012122-RA	5	Reactome: R-HSA-532668;MetaCyc: PWY-7919;KEGG: 00510+3.2.1.106;Reactome: R-HSA-4793954;MetaCyc: PWY-7918	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Protein N-glycosylation processing phase (plants and animals)";"N-Glycan biosynthesis";"Defective MOGS causes MOGS-CDG (CDG-2b)";"Protein N-glycosylation processing phase (yeast)"
Mdes002600-RB	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Mdes009539-RD	7	Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259	"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes"
Mdes000064-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes008512-RB	7	Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-177929;Reactome: R-HSA-2644606;Reactome: R-HSA-1442490;Reactome: R-HSA-2660826	"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Signaling by EGFR";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Collagen degradation";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant"
Mdes007824-RA	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
Mdes012061-RA	4	MetaCyc: PWY-7268;KEGG: 00480+1.1.1.49;MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49	"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism";"Entner-Doudoroff pathway I";"Pentose phosphate pathway"
Mdes008701-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Mdes006958-RD	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
Mdes010299-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Mdes009000-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes006292-RA	1	Reactome: R-HSA-8851805	"MET activates RAS signaling"
Mdes012002-RC	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes007235-RA	42	Reactome: R-HSA-201722;Reactome: R-HSA-427389;Reactome: R-HSA-3214847;Reactome: R-HSA-3214841;Reactome: R-HSA-171306;Reactome: R-HSA-5625886;Reactome: R-HSA-9616222;Reactome: R-HSA-73772;Reactome: R-HSA-2559586;Reactome: R-HSA-3214815;Reactome: R-HSA-9610379;Reactome: R-HSA-5693571;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-3214858;Reactome: R-HSA-5334118;Reactome: R-HSA-73728;Reactome: R-HSA-5693607;Reactome: R-HSA-8939236;Reactome: R-HSA-5578749;Reactome: R-HSA-8936459;Reactome: R-HSA-5617472;Reactome: R-HSA-5693565;Reactome: R-HSA-110328;Reactome: R-HSA-2559580;Reactome: R-HSA-110329;Reactome: R-HSA-110330;Reactome: R-HSA-2299718;Reactome: R-HSA-110331;Reactome: R-HSA-2559582;Reactome: R-HSA-9609690;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-606279;Reactome: R-HSA-1221632;Reactome: R-HSA-5250924;Reactome: R-HSA-912446;Reactome: R-HSA-212300;Reactome: R-HSA-427359;Reactome: R-HSA-4551638;Reactome: R-HSA-977225;Reactome: R-HSA-427413	"Formation of the beta-catenin:TCF transactivating complex";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HATs acetylate histones";"PKMTs methylate histone lysines";"Packaging Of Telomere Ends";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Transcriptional regulation of granulopoiesis";"RNA Polymerase I Promoter Escape";"DNA Damage/Telomere Stress Induced Senescence";"HDACs deacetylate histones";"HCMV Late Events";"Nonhomologous End-Joining (NHEJ)";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"RMTs methylate histone arginines";"DNA methylation";"RNA Polymerase I Promoter Opening";"Processing of DNA double-strand break ends";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Transcriptional regulation by small RNAs";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Oxidative Stress Induced Senescence";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected purine";"Condensation of Prophase Chromosomes";"Cleavage of the damaged purine";"Senescence-Associated Secretory Phenotype (SASP)";"HCMV Early Events";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Deposition of new CENPA-containing nucleosomes at the centromere";"Meiotic synapsis";"B-WICH complex positively regulates rRNA expression";"Meiotic recombination";"PRC2 methylates histones and DNA";"SIRT1 negatively regulates rRNA expression";"SUMOylation of chromatin organization proteins";"Amyloid fiber formation";"NoRC negatively regulates rRNA expression"
Mdes012056-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes007674-RA	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
Mdes006368-RA	12	Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-3371497;Reactome: R-HSA-380259;Reactome: R-HSA-381038;Reactome: R-HSA-2132295;Reactome: R-HSA-5620912;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436	"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Loss of Nlp from mitotic centrosomes";"XBP1(S) activates chaperone genes";"MHC class II antigen presentation";"Anchoring of the basal body to the plasma membrane";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic"
Mdes003427-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes004430-RA	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
Mdes005432-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Mdes001952-RA	2	Reactome: R-HSA-6807505;Reactome: R-HSA-163560	"RNA polymerase II transcribes snRNA genes";"Triglyceride catabolism"
Mdes010431-RB	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
Mdes008569-RA	9	Reactome: R-HSA-8943724;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-6798695;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-5674135;Reactome: R-HSA-9639288	"Regulation of PTEN gene transcription";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Neutrophil degranulation";"Macroautophagy";"TP53 Regulates Metabolic Genes";"MAP2K and MAPK activation";"Amino acids regulate mTORC1"
Mdes016128-RA	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
Mdes015086-RA	13	Reactome: R-HSA-71403;MetaCyc: PWY-5690;MetaCyc: PWY-6728;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-6969;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-7384;MetaCyc: PWY-5537;KEGG: 00020+6.2.1.5	"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Pyruvate fermentation to acetate V";"Citrate cycle (TCA cycle)"
Mdes001892-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes000180-RA	5	Reactome: R-HSA-73762;Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-427413	"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression"
Mdes005809-RC	3	Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism"
Mdes009569-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes001982-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes015441-RA	2	Reactome: R-HSA-6803157;Reactome: R-HSA-6798695	"Antimicrobial peptides";"Neutrophil degranulation"
Mdes012938-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes005432-RE	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Mdes003745-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes004595-RB	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Mdes000906-RA	7	Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259	"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes"
Mdes013526-RA	9	Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-167172	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome"
Mdes003977-RA	1	Reactome: R-HSA-373752	"Netrin-1 signaling"
Mdes008723-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Mdes010664-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes003687-RA	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
Mdes000602-RA	3	KEGG: 00330+1.14.11.2;Reactome: R-HSA-1650814;MetaCyc: PWY-7894	"Arginine and proline metabolism";"Collagen biosynthesis and modifying enzymes";"Procollagen hydroxylation and glycosylation"
Mdes001239-RC	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Mdes002784-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes006946-RA	6	Reactome: R-HSA-73762;Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-186797;Reactome: R-HSA-5250924;Reactome: R-HSA-427413	"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"Signaling by PDGF";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression"
Mdes011942-RA	6	Reactome: R-HSA-181430;Reactome: R-HSA-212676;Reactome: R-HSA-181429;Reactome: R-HSA-264642;Reactome: R-HSA-210500;Reactome: R-HSA-388844	"Norepinephrine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases"
Mdes010237-RA	13	Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes007417-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Mdes006700-RA	8	KEGG: 00900+1.1.1.34;MetaCyc: PWY-922;MetaCyc: PWY-7524;MetaCyc: PWY-7391;Reactome: R-HSA-2426168;MetaCyc: PWY-6174;Reactome: R-HSA-191273;Reactome: R-HSA-1989781	"Terpenoid backbone biosynthesis";"Mevalonate pathway I";"Mevalonate pathway III (archaea)";"Isoprene biosynthesis II (engineered)";"Activation of gene expression by SREBF (SREBP)";"Mevalonate pathway II (archaea)";"Cholesterol biosynthesis";"PPARA activates gene expression"
Mdes001982-RB	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes015268-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes017834-RA	3	MetaCyc: PWY-6829;MetaCyc: PWY-7285;MetaCyc: PWY-7286	"Trna methylation (yeast)";"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis"
Mdes007674-RB	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
Mdes007983-RA	4	KEGG: 00480+4.3.2.7;Reactome: R-HSA-194840;Reactome: R-HSA-174403;MetaCyc: PWY-7942	"Glutathione metabolism";"Rho GTPase cycle";"Glutathione synthesis and recycling";"5-oxo-L-proline metabolism"
Mdes016292-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes003192-RA	2	Reactome: R-HSA-8854518;Reactome: R-HSA-6804756	"AURKA Activation by TPX2";"Regulation of TP53 Activity through Phosphorylation"
Mdes019119-RA	1	Reactome: R-HSA-8963693	"Aspartate and asparagine metabolism"
Mdes017708-RA	8	Reactome: R-HSA-5659996;Reactome: R-HSA-71336;KEGG: 00030+5.3.1.6;Reactome: R-HSA-6791461;KEGG: 00051+5.3.1.6;KEGG: 00710+5.3.1.6;MetaCyc: PWY-1861;MetaCyc: PWY-5723	"RPIA deficiency: failed conversion of R5P to RU5P";"Pentose phosphate pathway";"Pentose phosphate pathway";"RPIA deficiency: failed conversion of RU5P to R5P";"Fructose and mannose metabolism";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Rubisco shunt"
Mdes009021-RB	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Mdes004453-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes015026-RA	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
Mdes014467-RA	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
Mdes009021-RA	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
Mdes014851-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes003664-RA	3	KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348	"Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition"
Mdes020135-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes010675-RB	3	Reactome: R-HSA-430039;Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"mRNA decay by 5' to 3' exoribonuclease";"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
Mdes018277-RA	2	KEGG: 00380+1.13.11.11;Reactome: R-HSA-71240	"Tryptophan metabolism";"Tryptophan catabolism"
Mdes006364-RC	2	Reactome: R-HSA-2132295;Reactome: R-HSA-114608	"MHC class II antigen presentation";"Platelet degranulation"
Mdes002522-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes000557-RB	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
Mdes004745-RA	17	Reactome: R-HSA-5358606;Reactome: R-HSA-5358565;Reactome: R-HSA-5696400;Reactome: R-HSA-69166;Reactome: R-HSA-5651801;Reactome: R-HSA-5685942;Reactome: R-HSA-69183;Reactome: R-HSA-110314;Reactome: R-HSA-174437;Reactome: R-HSA-174417;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-174411;Reactome: R-HSA-174414;Reactome: R-HSA-69091	"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Dual Incision in GG-NER";"Removal of the Flap Intermediate";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Homologous Recombination (HRR)";"Processive synthesis on the lagging strand";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate from the C-strand";"Telomere C-strand (Lagging Strand) Synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the C-strand of the telomere";"Polymerase switching"
Mdes001982-RC	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes011459-RA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
Mdes011504-RA	5	Reactome: R-HSA-4085001;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295;Reactome: R-HSA-4341670;Reactome: R-HSA-1660662	"Sialic acid metabolism";"Neutrophil degranulation";"MHC class II antigen presentation";"Defective NEU1 causes sialidosis";"Glycosphingolipid metabolism"
Mdes017631-RA	1	KEGG: 00330+3.5.1.96	"Arginine and proline metabolism"
Mdes017515-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes006025-RA	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
Mdes008711-RC	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes008558-RC	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes006158-RA	13	KEGG: 00531+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;KEGG: 00603+3.2.1.52;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00511+3.2.1.52;KEGG: 00520+3.2.1.52;MetaCyc: PWY-6902;Reactome: R-HSA-2160916	"Glycosaminoglycan degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid biosynthesis - ganglio series";"CS/DS degradation";"Other glycan degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)";"Hyaluronan uptake and degradation"
Mdes009151-RA	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
Mdes008536-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
Mdes007315-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes016147-RA	4	KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282;Reactome: R-HSA-964975;MetaCyc: PWY-7204	"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Vitamins B6 activation to pyridoxal phosphate";"Pyridoxal 5'-phosphate salvage II (plants)"
Mdes012335-RA	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
Mdes006926-RB	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Mdes007510-RA	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
Mdes002731-RA	7	KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980;Reactome: R-HSA-8949613;Reactome: R-HSA-1268020;Reactome: R-HSA-163210;Reactome: R-HSA-2151201;KEGG: 00195+7.1.2.2	"Oxidative phosphorylation";"ATP biosynthesis";"Cristae formation";"Mitochondrial protein import";"Formation of ATP by chemiosmotic coupling";"Transcriptional activation of mitochondrial biogenesis";"Photosynthesis"
Mdes007297-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Mdes008052-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes004386-RA	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
Mdes005730-RB	7	KEGG: 00520+2.6.1.16;KEGG: 00250+2.6.1.16;Reactome: R-HSA-380320;Reactome: R-HSA-446210;Reactome: R-HSA-380270;MetaCyc: PWY-8013;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"Alanine, aspartate and glutamate metabolism";"Recruitment of NuMA to mitotic centrosomes";"Synthesis of UDP-N-acetyl-glucosamine";"Recruitment of mitotic centrosome proteins and complexes";"UDP-N-acetyl-D-galactosamine biosynthesis III";"CMP-legionaminate biosynthesis I"
Mdes008454-RA	11	Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2173796;Reactome: R-HSA-9013508;Reactome: R-HSA-2894862;Reactome: R-HSA-210744;Reactome: R-HSA-72163;Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-8941856;Reactome: R-HSA-9013695	"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"mRNA Splicing - Major Pathway";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"RUNX3 regulates NOTCH signaling";"NOTCH4 Intracellular Domain Regulates Transcription"
Mdes007560-RA	4	Reactome: R-HSA-3000157;Reactome: R-HSA-3000178;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"ECM proteoglycans";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
Mdes016993-RA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
Mdes016817-RA	2	MetaCyc: PWY-7560;KEGG: 00900+1.1.1.267	"Methylerythritol phosphate pathway II";"Terpenoid backbone biosynthesis"
Mdes006485-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes003333-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes020000-RA	3	MetaCyc: PWY-7999;KEGG: 00130+1.6.5.2;MetaCyc: PWY-7731	"Vitamin K-epoxide cycle";"Ubiquinone and other terpenoid-quinone biosynthesis";"Superpathway of photosynthetic hydrogen production"
Mdes007711-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Mdes006735-RA	13	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes016264-RA	6	Reactome: R-HSA-8949613;MetaCyc: PWY-7980;KEGG: 00190+7.1.2.2;Reactome: R-HSA-1268020;Reactome: R-HSA-163210;KEGG: 00195+7.1.2.2	"Cristae formation";"ATP biosynthesis";"Oxidative phosphorylation";"Mitochondrial protein import";"Formation of ATP by chemiosmotic coupling";"Photosynthesis"
Mdes007713-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Mdes006734-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6784531	"Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus"
Mdes011124-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes006266-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes006279-RA	4	Reactome: R-HSA-5660862;Reactome: R-HSA-352230;Reactome: R-HSA-210991;Reactome: R-HSA-71240	"Defective SLC7A7 causes lysinuric protein intolerance (LPI)";"Amino acid transport across the plasma membrane";"Basigin interactions";"Tryptophan catabolism"
Mdes005814-RA	1	Reactome: R-HSA-1483101	"Synthesis of PS"
Mdes007597-RB	16	Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764	"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination"
Mdes002209-RA	25	Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-2467813;Reactome: R-HSA-190840;Reactome: R-HSA-3371497;Reactome: R-HSA-5626467;Reactome: R-HSA-9609736;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-8955332;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-9648025;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-380270;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-6811434	"Kinesins";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"Cilium Assembly";"MHC class II antigen presentation";"Separation of Sister Chromatids";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases activate IQGAPs";"Assembly and cell surface presentation of NMDA receptors";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin";"Mitotic Prometaphase";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Gap junction assembly";"EML4 and NUDC in mitotic spindle formation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Recruitment of mitotic centrosome proteins and complexes";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes007576-RA	1	Reactome: R-HSA-191859	"snRNP Assembly"
Mdes004877-RB	2	Reactome: R-HSA-5673001;Reactome: R-HSA-8853659	"RAF/MAP kinase cascade";"RET signaling"
Mdes007222-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes003682-RA	6	Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-5685938;Reactome: R-HSA-69473;Reactome: R-HSA-6804756	"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"HDR through Single Strand Annealing (SSA)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation"
Mdes005604-RB	8	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Activation of RAC1";"Human papillomavirus infection"
Mdes016793-RA	15	Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-1912408;Reactome: R-HSA-8853884;Reactome: R-HSA-4086398;Reactome: R-HSA-8948700;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-8936459	"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by VENTX";"Ca2+ pathway";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Mdes011774-RA	1	KEGG: 00240+3.1.3.89	"Pyrimidine metabolism"
Mdes001040-RA	6	Reactome: R-HSA-201722;Reactome: R-HSA-4086398;Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-4411364;Reactome: R-HSA-8951430	"Formation of the beta-catenin:TCF transactivating complex";"Ca2+ pathway";"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"RUNX3 regulates WNT signaling"
Mdes012615-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes002567-RA	4	Reactome: R-HSA-611105;Reactome: R-HSA-6790901;Reactome: R-HSA-6791226;Reactome: R-HSA-6799198	"Respiratory electron transport";"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol";"Complex I biogenesis"
Mdes002585-RA	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
Mdes000117-RA	4	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72163	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway"
Mdes004702-RA	1	Reactome: R-HSA-70350	"Fructose catabolism"
Mdes010981-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes003772-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes017674-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes011845-RA	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
Mdes010885-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes002050-RB	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes009822-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes001543-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes008193-RA	4	KEGG: 00380+1.14.16.4;MetaCyc: PWY-6030;Reactome: R-HSA-209931;KEGG: 00790+1.14.16.4	"Tryptophan metabolism";"Serotonin and melatonin biosynthesis";"Serotonin and melatonin biosynthesis";"Folate biosynthesis"
Mdes001715-RA	4	Reactome: R-HSA-964975;MetaCyc: PWY-7204;KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282	"Vitamins B6 activation to pyridoxal phosphate";"Pyridoxal 5'-phosphate salvage II (plants)";"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis"
Mdes009156-RC	3	Reactome: R-HSA-983189;Reactome: R-HSA-390471;Reactome: R-HSA-6811434	"Kinesins";"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes012141-RA	10	KEGG: 00332+1.2.1.41+2.7.2.11;Reactome: R-HSA-8964539;KEGG: 00330+1.2.1.41;MetaCyc: PWY-6922;KEGG: 00332+2.7.2.11;KEGG: 00332+2.7.2.11+1.2.1.41;KEGG: 00330+2.7.2.11;KEGG: 00330+1.2.1.41+2.7.2.11;KEGG: 00330+2.7.2.11+1.2.1.41;KEGG: 00332+1.2.1.41	"Carbapenem biosynthesis";"Glutamate and glutamine metabolism";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis";"Carbapenem biosynthesis";"Carbapenem biosynthesis";"Arginine and proline metabolism";"Arginine and proline metabolism";"Arginine and proline metabolism";"Carbapenem biosynthesis"
Mdes008973-RA	3	Reactome: R-HSA-3214841;Reactome: R-HSA-2299718;Reactome: R-HSA-6804760	"PKMTs methylate histone lysines";"Condensation of Prophase Chromosomes";"Regulation of TP53 Activity through Methylation"
Mdes010379-RA	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440	"RAB GEFs exchange GTP for GDP on RABs";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network"
Mdes009201-RC	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes005041-RB	17	Reactome: R-HSA-5696397;Reactome: R-HSA-174417;Reactome: R-HSA-110314;Reactome: R-HSA-174437;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-69091;Reactome: R-HSA-174414;Reactome: R-HSA-5358606;Reactome: R-HSA-5358565;Reactome: R-HSA-69166;Reactome: R-HSA-5696400;Reactome: R-HSA-5685942;Reactome: R-HSA-69183;Reactome: R-HSA-5651801	"Gap-filling DNA repair synthesis and ligation in GG-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate from the C-strand";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching";"Processive synthesis on the C-strand of the telomere";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Removal of the Flap Intermediate";"Dual Incision in GG-NER";"HDR through Homologous Recombination (HRR)";"Processive synthesis on the lagging strand";"PCNA-Dependent Long Patch Base Excision Repair"
Mdes010351-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes012256-RA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
Mdes002360-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes012869-RB	5	Reactome: R-HSA-196807;Reactome: R-HSA-73621;MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Purine catabolism"
Mdes008974-RA	1	KEGG: 00270+2.1.1.37	"Cysteine and methionine metabolism"
Mdes018351-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes005722-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
Mdes010862-RA	5	Reactome: R-HSA-5685938;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-5696400;Reactome: R-HSA-6783310	"HDR through Single Strand Annealing (SSA)";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Dual Incision in GG-NER";"Fanconi Anemia Pathway"
Mdes003712-RA	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
Mdes000941-RA	4	Reactome: R-HSA-418594;Reactome: R-HSA-112043;Reactome: R-HSA-202040;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"PLC beta mediated events";"G-protein activation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
Mdes004504-RB	2	Reactome: R-HSA-2514853;Reactome: R-HSA-2299718	"Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes"
Mdes003029-RC	4	MetaCyc: PWY-7193;KEGG: 00983+2.7.1.48;KEGG: 00240+2.7.1.48;Reactome: R-HSA-73614	"Pyrimidine ribonucleosides salvage I";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"Pyrimidine salvage"
Mdes009364-RA	8	Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-165054;Reactome: R-HSA-9648025;Reactome: R-HSA-4615885	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Rev-mediated nuclear export of HIV RNA";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA replication proteins"
Mdes016012-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes003897-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes000421-RA	5	Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-73772;Reactome: R-HSA-73863	"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination"
Mdes002410-RA	2	KEGG: 00450+6.1.1.10;KEGG: 00970+6.1.1.10	"Selenocompound metabolism";"Aminoacyl-tRNA biosynthesis"
Mdes009734-RA	7	KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1	"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis"
Mdes001525-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Mdes000998-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes002238-RB	13	Reactome: R-HSA-3000178;Reactome: R-HSA-2022090;Reactome: R-HSA-186797;Reactome: R-HSA-1474244;Reactome: R-HSA-419037;Reactome: R-HSA-3000157;Reactome: R-HSA-216083;Reactome: R-HSA-2243919;Reactome: R-HSA-3000171;Reactome: R-HSA-1650814;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216;Reactome: R-HSA-2214320	"ECM proteoglycans";"Assembly of collagen fibrils and other multimeric structures";"Signaling by PDGF";"Extracellular matrix organization";"NCAM1 interactions";"Laminin interactions";"Integrin cell surface interactions";"Crosslinking of collagen fibrils";"Non-integrin membrane-ECM interactions";"Collagen biosynthesis and modifying enzymes";"Collagen degradation";"Collagen chain trimerization";"Anchoring fibril formation"
Mdes001789-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes017300-RC	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes013098-RA	4	Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism"
Mdes006620-RC	4	Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-375165;Reactome: R-HSA-5673001	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade"
Mdes017337-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes012723-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes008990-RA	17	Reactome: R-HSA-5357956;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-975163;Reactome: R-HSA-937072;Reactome: R-HSA-168638;Reactome: R-HSA-9014325;Reactome: R-HSA-9645460;Reactome: R-HSA-937042;Reactome: R-HSA-5689880;Reactome: R-HSA-445989;Reactome: R-HSA-450302;Reactome: R-HSA-9020702;Reactome: R-HSA-4086398;Reactome: R-HSA-5607764;Reactome: R-HSA-450321	"TNFR1-induced NFkappaB signaling pathway";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"NOD1/2 Signaling Pathway";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Alpha-protein kinase 1 signaling pathway";"IRAK2 mediated activation of TAK1 complex";"Ub-specific processing proteases";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"activated TAK1 mediates p38 MAPK activation";"Interleukin-1 signaling";"Ca2+ pathway";"CLEC7A (Dectin-1) signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"
Mdes010806-RA	5	Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-430039;Reactome: R-HSA-450385	"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 5' to 3' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes008484-RB	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes003677-RA	1	Reactome: R-HSA-196783	"Coenzyme A biosynthesis"
Mdes008838-RA	4	KEGG: 00514+2.4.1.255;Reactome: R-HSA-5689603;MetaCyc: PWY-7437;Reactome: R-HSA-3214847	"Other types of O-glycan biosynthesis";"UCH proteinases";"Protein O-[N-acetyl]-glucosylation";"HATs acetylate histones"
Mdes003792-RC	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
Mdes009091-RA	8	KEGG: 00521+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00524+2.7.1.1;Reactome: R-HSA-70171	"Streptomycin biosynthesis";"Starch and sucrose metabolism";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Glycolysis"
Mdes013870-RA	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
Mdes010597-RA	15	Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-1912408;Reactome: R-HSA-2559580;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-8936459;Reactome: R-HSA-8986944	"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Pre-NOTCH Transcription and Translation";"Oxidative Stress Induced Senescence";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by MECP2"
Mdes014482-RA	5	Reactome: R-HSA-6782135;Reactome: R-HSA-72163;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823	"Dual incision in TC-NER";"mRNA Splicing - Major Pathway";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex"
Mdes001886-RC	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
Mdes002971-RA	4	MetaCyc: PWY-7437;KEGG: 00514+2.4.1.255;Reactome: R-HSA-5689603;Reactome: R-HSA-3214847	"Protein O-[N-acetyl]-glucosylation";"Other types of O-glycan biosynthesis";"UCH proteinases";"HATs acetylate histones"
Mdes003898-RA	2	KEGG: 00340+2.1.1.22;Reactome: R-HSA-70921	"Histidine metabolism";"Histidine catabolism"
Mdes008641-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Mdes011091-RA	9	Reactome: R-HSA-8943724;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-166208;Reactome: R-HSA-6798695;Reactome: R-HSA-1632852;Reactome: R-HSA-5674135;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288	"Regulation of PTEN gene transcription";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"mTORC1-mediated signalling";"Neutrophil degranulation";"Macroautophagy";"MAP2K and MAPK activation";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1"
Mdes006825-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes009680-RA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
Mdes005705-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes000921-RA	1	Reactome: R-HSA-8849175	"Threonine catabolism"
Mdes000328-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes009837-RA	7	Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;MetaCyc: PWY-7511;Reactome: R-HSA-9013507	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Protein ubiquitination";"NOTCH3 Activation and Transmission of Signal to the Nucleus"
Mdes003601-RA	2	Reactome: R-HSA-5689880;Reactome: R-HSA-5689896	"Ub-specific processing proteases";"Ovarian tumor domain proteases"
Mdes010140-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes004259-RA	13	MetaCyc: PWY-6545;MetaCyc: PWY-7210;KEGG: 00983+1.17.4.1;Reactome: R-HSA-499943;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7184;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7222;MetaCyc: PWY-7220;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7226	"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes";"Interconversion of nucleotide di- and triphosphates";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I"
Mdes002882-RD	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes007910-RA	10	MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-7385;KEGG: 00030+2.7.1.11;Reactome: R-HSA-70171;KEGG: 00051+2.7.1.11;MetaCyc: PWY-1861;KEGG: 00052+2.7.1.11;KEGG: 00010+2.7.1.11;KEGG: 00680+2.7.1.11	"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Pentose phosphate pathway";"Glycolysis";"Fructose and mannose metabolism";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Galactose metabolism";"Glycolysis / Gluconeogenesis";"Methane metabolism"
Mdes001617-RB	26	Reactome: R-HSA-6811434;Reactome: R-HSA-5663220;Reactome: R-HSA-8852276;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-9648025;Reactome: R-HSA-389977;Reactome: R-HSA-389960;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-8955332;Reactome: R-HSA-380320;Reactome: R-HSA-437239;Reactome: R-HSA-9609736;Reactome: R-HSA-5626467;Reactome: R-HSA-3371497;Reactome: R-HSA-2467813;Reactome: R-HSA-190840;Reactome: R-HSA-2132295;Reactome: R-HSA-2500257;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"EML4 and NUDC in mitotic spindle formation";"Post-chaperonin tubulin folding pathway";"Formation of tubulin folding intermediates by CCT/TriC";"Aggrephagy";"Gap junction assembly";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"Carboxyterminal post-translational modifications of tubulin";"Recruitment of NuMA to mitotic centrosomes";"Recycling pathway of L1";"Assembly and cell surface presentation of NMDA receptors";"RHO GTPases activate IQGAPs";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Separation of Sister Chromatids";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"MHC class II antigen presentation";"Resolution of Sister Chromatid Cohesion";"Cilium Assembly";"COPI-mediated anterograde transport";"Kinesins"
Mdes000588-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes018721-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes002752-RA	7	Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-4615885;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"SUMOylation of DNA replication proteins";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
Mdes009493-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes002499-RB	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes006845-RA	4	Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497	"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Mdes011432-RA	6	Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72695	"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex"
Mdes009300-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes009881-RB	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Mdes006628-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes000394-RB	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes008808-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Mdes001648-RA	2	Reactome: R-HSA-189451;KEGG: 00860+4.99.1.1	"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
Mdes002286-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes007336-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes007685-RA	5	Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-9614657;Reactome: R-HSA-380994;Reactome: R-HSA-381183	"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"FOXO-mediated transcription of cell death genes";"ATF4 activates genes in response to endoplasmic reticulum stress";"ATF6 (ATF6-alpha) activates chaperone genes"
Mdes007430-RB	13	Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression"
Mdes017143-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes008235-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes018280-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes012088-RA	10	MetaCyc: PWY-4041;MetaCyc: PWY-7559;MetaCyc: PWY-6842;MetaCyc: PWY-7112;MetaCyc: PWY-5826;KEGG: 00460+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2	"Gamma-glutamyl cycle";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II";"4-hydroxy-2-nonenal detoxification";"Hypoglycin biosynthesis";"Cyanoamino acid metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Glutathione metabolism";"Taurine and hypotaurine metabolism"
Mdes005329-RA	2	Reactome: R-HSA-5223345;Reactome: R-HSA-425393	"Miscellaneous transport and binding events";"Transport of inorganic cations/anions and amino acids/oligopeptides"
Mdes018121-RA	14	KEGG: 00500+2.7.1.2;KEGG: 00521+2.7.1.2;KEGG: 00520+2.7.1.2;KEGG: 00524+2.7.1.2;MetaCyc: PWY-5941;MetaCyc: PWY-5661;KEGG: 00010+2.7.1.2;MetaCyc: PWY-5514;MetaCyc: PWY-7238;KEGG: 00052+2.7.1.2;MetaCyc: PWY-2722;MetaCyc: PWY-7385;MetaCyc: PWY-621;MetaCyc: PWY-2723	"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Glycogen degradation II";"GDP-glucose biosynthesis";"Glycolysis / Gluconeogenesis";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Sucrose biosynthesis II";"Galactose metabolism";"Trehalose degradation IV";"1,3-propanediol biosynthesis (engineered)";"Sucrose degradation III (sucrose invertase)";"Trehalose degradation V"
Mdes007652-RA	11	Reactome: R-HSA-164378;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-418597;KEGG: 00230+4.6.1.1;Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-418594	"PKA activation in glucagon signalling";"PKA activation";"Hedgehog 'off' state";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"G alpha (z) signalling events";"Purine metabolism";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"G alpha (i) signalling events"
Mdes012500-RD	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Mdes006185-RA	7	MetaCyc: PWY-882;MetaCyc: PWY-7586;MetaCyc: PWY-5659;Reactome: R-HSA-446205;MetaCyc: PWY-7456;KEGG: 00051+5.4.2.8;KEGG: 00520+5.4.2.8	"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"GDP-mannose biosynthesis";"Synthesis of GDP-mannose";"Beta-(1,4)-mannan degradation";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism"
Mdes006191-RA	14	Reactome: R-HSA-167158;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167200;Reactome: R-HSA-167243;Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955	"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation"
Mdes018727-RA	2	MetaCyc: PWY-6890;KEGG: 00730+4.1.99.17	"4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis";"Thiamine metabolism"
Mdes001843-RA	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
Mdes001078-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes004384-RB	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6785470	"tRNA processing in the nucleus";"tRNA processing in the mitochondrion"
Mdes005064-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes003987-RB	6	Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450385	"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes002446-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes009961-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes019607-RA	3	Reactome: R-HSA-379726;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.14	"Mitochondrial tRNA aminoacylation";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes014914-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes006588-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-5205685	"Mitochondrial protein import";"Pink/Parkin Mediated Mitophagy"
Mdes004808-RA	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
Mdes000886-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689	"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits"
Mdes017458-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1660662	"Neutrophil degranulation";"Glycosphingolipid metabolism"
Mdes014441-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes018193-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Mdes007735-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes011623-RB	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes014050-RA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
Mdes013508-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes001231-RA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
Mdes012107-RA	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
Mdes001669-RA	6	MetaCyc: PWY-5269;MetaCyc: PWY-7817;Reactome: R-HSA-1483166;KEGG: 00564+2.7.8.5;Reactome: R-HSA-1483148;MetaCyc: PWY-5668	"Cardiolipin biosynthesis II";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Synthesis of PA";"Glycerophospholipid metabolism";"Synthesis of PG";"Cardiolipin biosynthesis I"
Mdes010231-RC	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes014714-RA	5	KEGG: 00052+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00561+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22	"Galactose metabolism";"Stachyose degradation";"Glycerolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism"
Mdes009855-RB	2	Reactome: R-HSA-1483115;Reactome: R-HSA-1483152	"Hydrolysis of LPC";"Hydrolysis of LPE"
Mdes002658-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes005869-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-5689880	"HATs acetylate histones";"Ub-specific processing proteases"
Mdes003504-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes003648-RA	10	Reactome: R-HSA-1483166;MetaCyc: PWY-8055;MetaCyc: PWY-5667;MetaCyc: PWY-8053;MetaCyc: PWY-7411;KEGG: 00564+2.3.1.15;MetaCyc: PWY-7587;MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.15	"Synthesis of PA";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis II";"Phosphatidate biosynthesis (yeast)";"Glycerophospholipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism"
Mdes003690-RI	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Mdes019939-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Mdes004652-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression"
Mdes019765-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes003928-RA	2	Reactome: R-HSA-162710;KEGG: 00563+3.5.1.89	"Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"
Mdes001209-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Mdes002918-RA	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
Mdes012415-RB	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Mdes017726-RA	21	MetaCyc: PWY-7657;MetaCyc: PWY-6942;MetaCyc: PWY-7440;MetaCyc: PWY-6976;MetaCyc: PWY-7414;MetaCyc: PWY-7318;MetaCyc: PWY-7312;MetaCyc: PWY-7301;KEGG: 00521+2.7.7.24;MetaCyc: PWY-7814;MetaCyc: PWY-7688;MetaCyc: PWY-6953;MetaCyc: PWY-6973;KEGG: 00523+2.7.7.24;MetaCyc: PWY-6808;MetaCyc: PWY-7413;MetaCyc: PWY-7316;MetaCyc: PWY-7104;KEGG: 00525+2.7.7.24;MetaCyc: PWY-7315;MetaCyc: PWY-6974	"Dtdp-beta-l-digitoxose biosynthesis";"Dtdp-d-desosamine biosynthesis";"Dtdp-beta-l-4-epi-vancosamine biosynthesis";"Dtdp-l-mycarose biosynthesis";"Dtdp-alpha-d-mycaminose biosynthesis";"Dtdp-3-acetamido-3,6-dideoxy-alpha-d-glucose biosynthesis";"Dtdp-d-beta-fucofuranose biosynthesis";"Dtdp-4-o-demethyl-beta-l-noviose biosynthesis";"Streptomycin biosynthesis";"Dtdp-l-daunosamine biosynthesis";"Dtdp-d-ravidosamine and dTDP-4-acetyl-D-ravidosamine biosynthesis";"Dtdp-3-acetamido-alpha-d-fucose biosynthesis";"Dtdp-d-olivose, dTDP-D-oliose and dTDP-D-mycarose biosynthesis";"Polyketide sugar unit biosynthesis";"Dtdp-d-forosamine biosynthesis";"Dtdp-6-deoxy-alpha-d-allose biosynthesis";"Dtdp-n-acetylviosamine biosynthesis";"Dtdp-l-megosamine biosynthesis";"Acarbose and validamycin biosynthesis";"Dtdp-n-acetylthomosamine biosynthesis";"Dtdp-l-olivose biosynthesis"
Mdes000367-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-6803157	"Neutrophil degranulation";"Antimicrobial peptides"
Mdes007042-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes006346-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Mdes010348-RA	2	KEGG: 00280+1.3.8.4;Reactome: R-HSA-70895	"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism"
Mdes010166-RA	9	MetaCyc: PWY-8052;MetaCyc: PWY-7039;Reactome: R-HSA-416476;MetaCyc: PWY-6351;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;Reactome: R-HSA-1855204;Reactome: R-HSA-112043	"2-arachidonoylglycerol biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"G alpha (q) signalling events";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"PLC beta mediated events"
Mdes002645-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes005169-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Mdes003614-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Mdes003863-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes010544-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes012582-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes003627-RA	7	Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-1834949	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Cytosolic sensors of pathogen-associated DNA"
Mdes001676-RA	2	Reactome: R-HSA-426486;Reactome: R-HSA-203927	"Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis"
Mdes000944-RD	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes009892-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes018638-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes005746-RA	7	Reactome: R-HSA-6799198;Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-611105;Reactome: R-HSA-6811440;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Complex I biogenesis";"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Respiratory electron transport";"Retrograde transport at the Trans-Golgi-Network";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes015737-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes016722-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes014076-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
Mdes001233-RA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
Mdes003511-RA	4	Reactome: R-HSA-6794361;Reactome: R-HSA-8856828;Reactome: R-HSA-5250958;Reactome: R-HSA-8856825	"Neurexins and neuroligins";"Clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis"
Mdes000663-RA	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
Mdes002882-RB	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes014083-RA	3	Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807	"Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism"
Mdes013527-RA	20	Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5656121;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-5651801;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-69091;Reactome: R-HSA-110320	"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Translesion synthesis by POLI";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"Polymerase switching";"Translesion Synthesis by POLH"
Mdes015720-RA	2	Reactome: R-HSA-167826;Reactome: R-HSA-167827	"The fatty acid cycling model";"The proton buffering model"
Mdes005699-RA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72649	"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation"
Mdes010218-RA	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
Mdes004922-RA	4	Reactome: R-HSA-975138;Reactome: R-HSA-975871;Reactome: R-HSA-6799198;Reactome: R-HSA-166058	"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"MyD88 cascade initiated on plasma membrane";"Complex I biogenesis";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane"
Mdes016237-RA	57	Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-4641257;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-5668541;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-5687128;Reactome: R-HSA-6798695;Reactome: R-HSA-450408;Reactome: R-HSA-5607764;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949	"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Neddylation";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of AXIN";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"TNFR2 non-canonical NF-kB pathway";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"MAPK6/MAPK4 signaling";"Neutrophil degranulation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CLEC7A (Dectin-1) signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin"
Mdes012861-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes007278-RA	7	Reactome: R-HSA-69202;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-156711;Reactome: R-HSA-69656;Reactome: R-HSA-69205;Reactome: R-HSA-1538133	"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"Polo-like kinase mediated events";"Cyclin A:Cdk2-associated events at S phase entry";"G1/S-Specific Transcription";"G0 and Early G1"
Mdes015789-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes000142-RD	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Mdes009374-RB	7	KEGG: 00521+3.1.3.25;MetaCyc: PWY-2301;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.25;MetaCyc: PWY-4702;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25	"Streptomycin biosynthesis";"Myo-inositol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism";"Phytate degradation I";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system"
Mdes007562-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Relaxin signaling pathway"
Mdes009734-RB	7	KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1	"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway"
Mdes013194-RA	16	Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553	"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
Mdes001235-RB	3	KEGG: 00680+3.1.3.3;KEGG: 00260+3.1.3.3;Reactome: R-HSA-977347	"Methane metabolism";"Glycine, serine and threonine metabolism";"Serine biosynthesis"
Mdes001634-RA	3	KEGG: 00350+3.7.1.2;KEGG: 00643+3.7.1.2;Reactome: R-HSA-8963684	"Tyrosine metabolism";"Styrene degradation";"Tyrosine catabolism"
Mdes003923-RB	3	Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-112382	"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex"
Mdes009052-RA	1	Reactome: R-HSA-390651	"Dopamine receptors"
Mdes001782-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes013021-RA	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
Mdes014298-RA	5	Reactome: R-HSA-532668;Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-879415;Reactome: R-HSA-901042	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Advanced glycosylation endproduct receptor signaling";"Calnexin/calreticulin cycle"
Mdes005409-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes012623-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes014762-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes001438-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes019146-RA	15	Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-5693565;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693571;Reactome: R-HSA-5685939;Reactome: R-HSA-5693568;Reactome: R-HSA-2559586;Reactome: R-HSA-5685938;Reactome: R-HSA-5693548;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942	"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"Processing of DNA double-strand break ends";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Nonhomologous End-Joining (NHEJ)";"HDR through MMEJ (alt-NHEJ)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"DNA Damage/Telomere Stress Induced Senescence";"HDR through Single Strand Annealing (SSA)";"Sensing of DNA Double Strand Breaks";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)"
Mdes014683-RA	12	MetaCyc: PWY-7817;KEGG: 00052+2.7.7.9;MetaCyc: PWY-6527;KEGG: 00040+2.7.7.9;MetaCyc: PWY-7343;KEGG: 00520+2.7.7.9;MetaCyc: PWY-7238;MetaCyc: PWY-3801;Reactome: R-HSA-173599;KEGG: 00500+2.7.7.9;Reactome: R-HSA-3322077;KEGG: 00561+2.7.7.9	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Galactose metabolism";"Stachyose degradation";"Pentose and glucuronate interconversions";"UDP-alpha-D-glucose biosynthesis I";"Amino sugar and nucleotide sugar metabolism";"Sucrose biosynthesis II";"Sucrose degradation II (sucrose synthase)";"Formation of the active cofactor, UDP-glucuronate";"Starch and sucrose metabolism";"Glycogen synthesis";"Glycerolipid metabolism"
Mdes009251-RA	2	Reactome: R-HSA-5357905;Reactome: R-HSA-8876198	"Regulation of TNFR1 signaling";"RAB GEFs exchange GTP for GDP on RABs"
Mdes015214-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-6811436	"RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic"
Mdes016727-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes013640-RA	6	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72702	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition"
Mdes000820-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes001599-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes007275-RA	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
Mdes016976-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes003307-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Mdes003645-RA	59	Reactome: R-HSA-349425;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-5668541;Reactome: R-HSA-5419276;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-5389840;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-187577;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-5368286;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764	"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Neddylation";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"TNFR2 non-canonical NF-kB pathway";"Mitochondrial translation termination";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Mitochondrial translation elongation";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Ub-specific processing proteases";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"Mitochondrial translation initiation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling"
Mdes010501-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Mdes002507-RA	14	MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-7602;MetaCyc: PWY-5972	"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)"
Mdes017813-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes012656-RA	3	Reactome: R-HSA-983168;Reactome: R-HSA-3065676;Reactome: R-HSA-3065678	"Antigen processing: Ubiquitination & Proteasome degradation";"SUMO is conjugated to E1 (UBA2:SAE1)";"SUMO is transferred from E1 to E2 (UBE2I, UBC9)"
Mdes006150-RA	4	Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-5689880;Reactome: R-HSA-111465	"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"Ub-specific processing proteases";"Apoptotic cleavage of cellular proteins"
Mdes017670-RA	2	MetaCyc: PWY-6163;KEGG: 00400+2.7.1.71	"Chorismate biosynthesis from 3-dehydroquinate";"Phenylalanine, tyrosine and tryptophan biosynthesis"
Mdes001787-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Mdes018512-RA	9	MetaCyc: PWY-5755;KEGG: 00130+4.1.3.40;MetaCyc: PWY-7929;MetaCyc: PWY-7934;MetaCyc: PWY-7935;MetaCyc: PWY-6148;MetaCyc: PWY-7745;MetaCyc: PWY-7742;MetaCyc: PWY-5870	"4-hydroxybenzoate biosynthesis II (bacteria)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Polybrominated phenols biosynthesis";"Polybrominated dihydroxylated diphenyl ethers biosynthesis";"Spongiadioxin C biosynthesis";"Tetrahydromethanopterin biosynthesis";"P-hbad biosynthesis";"Phenolphthiocerol biosynthesis";"Ubiquinol-8 biosynthesis (eukaryotic)"
Mdes001373-RA	5	Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-72163	"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway"
Mdes017636-RA	2	MetaCyc: PWY-6164;KEGG: 00400+4.2.3.4	"3-dehydroquinate biosynthesis I";"Phenylalanine, tyrosine and tryptophan biosynthesis"
Mdes007210-RA	3	Reactome: R-HSA-8964058;Reactome: R-HSA-1369062;Reactome: R-HSA-9029569	"HDL remodeling";"ABC transporters in lipid homeostasis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
Mdes003435-RA	7	Reactome: R-HSA-1221632;Reactome: R-HSA-2468052;Reactome: R-HSA-3108214;Reactome: R-HSA-9018519;Reactome: R-HSA-2467813;Reactome: R-HSA-2470946;Reactome: R-HSA-2500257	"Meiotic synapsis";"Establishment of Sister Chromatid Cohesion";"SUMOylation of DNA damage response and repair proteins";"Estrogen-dependent gene expression";"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion"
Mdes008705-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes009283-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes002183-RC	28	Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-4615885;Reactome: R-HSA-8876198;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-3371453;Reactome: R-HSA-168276;Reactome: R-HSA-159230;Reactome: R-HSA-3108214;Reactome: R-HSA-4551638;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-168333	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"HCMV Late Events";"ISG15 antiviral mechanism";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA replication proteins";"RAB GEFs exchange GTP for GDP on RABs";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Regulation of HSF1-mediated heat shock response";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery"
Mdes016399-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Mdes010011-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes014537-RA	1	Reactome: R-HSA-71262	"Carnitine synthesis"
Mdes006612-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes018209-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes018184-RA	8	MetaCyc: PWY-2221;MetaCyc: PWY-7242;MetaCyc: PWY-6507;KEGG: 00330+4.1.3.16;MetaCyc: PWY-7310;KEGG: 00630+4.1.3.16;KEGG: 00030+4.1.2.14;MetaCyc: PWY-7562	"Entner-Doudoroff pathway III (semi-phosphorylative)";"D-fructuronate degradation";"4-deoxy-L-threo-hex-4-enopyranuronate degradation";"Arginine and proline metabolism";"D-glucosaminate degradation";"Glyoxylate and dicarboxylate metabolism";"Pentose phosphate pathway";"3,6-anhydro-alpha-L-galactopyranose degradation"
Mdes006929-RA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
Mdes004884-RA	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
Mdes010526-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes012064-RA	3	Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes000136-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes005714-RA	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
Mdes004133-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Mdes002259-RA	3	Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.19	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes003560-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes005327-RA	5	MetaCyc: PWY-4981;MetaCyc: PWY-6344;MetaCyc: PWY-3341;Reactome: R-HSA-8964539;KEGG: 00330+1.5.1.2	"L-proline biosynthesis II (from arginine)";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis III (from L-ornithine)";"Glutamate and glutamine metabolism";"Arginine and proline metabolism"
Mdes010963-RA	56	Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-187577;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-5668541	"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"Ub-specific processing proteases";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Neddylation";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"TNFR2 non-canonical NF-kB pathway"
Mdes013698-RA	6	Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68962	"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Switching of origins to a post-replicative state";"Unwinding of DNA";"Orc1 removal from chromatin";"Activation of the pre-replicative complex"
Mdes006567-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Mdes018815-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes010112-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes010450-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes002767-RA	2	MetaCyc: PWY-6938;Reactome: R-HSA-430039	"NADH repair";"mRNA decay by 5' to 3' exoribonuclease"
Mdes009828-RB	4	MetaCyc: PWY-6619;KEGG: 00230+2.7.1.20;Reactome: R-HSA-2672351;Reactome: R-HSA-74217	"Adenine and adenosine salvage VI";"Purine metabolism";"Stimuli-sensing channels";"Purine salvage"
Mdes014146-RD	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
Mdes014660-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Mdes000544-RA	6	Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72689	"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits"
Mdes007892-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Mdes016572-RC	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Mdes019844-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes002822-RA	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes001104-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Mdes004425-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Mdes012487-RB	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
Mdes012391-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes013591-RE	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes001477-RA	19	Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-3214858;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-6790901;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-8876725;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"RMTs methylate histone arginines";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"rRNA modification in the nucleus and cytosol";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Protein methylation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes013701-RA	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
Mdes003248-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Mdes001092-RB	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes002330-RA	2	Reactome: R-HSA-6803205;Reactome: R-HSA-8873719	"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"RAB geranylgeranylation"
Mdes008830-RB	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes005282-RA	4	Reactome: R-HSA-532668;Reactome: R-HSA-5696394;Reactome: R-HSA-3108214;Reactome: R-HSA-5696395	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"DNA Damage Recognition in GG-NER";"SUMOylation of DNA damage response and repair proteins";"Formation of Incision Complex in GG-NER"
Mdes012717-RA	10	KEGG: 00010+2.7.2.3;MetaCyc: PWY-6886;MetaCyc: PWY-6901;Reactome: R-HSA-70263;MetaCyc: PWY-7003;KEGG: 00710+2.7.2.3;MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-8004;Reactome: R-HSA-70171	"Glycolysis / Gluconeogenesis";"1-butanol autotrophic biosynthesis (engineered)";"Superpathway of glucose and xylose degradation";"Gluconeogenesis";"Glycerol degradation to butanol";"Carbon fixation in photosynthetic organisms";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Entner-Doudoroff pathway I";"Glycolysis"
Mdes018387-RA	6	KEGG: 00051+3.1.3.11;KEGG: 00030+3.1.3.11;MetaCyc: PWY-5484;KEGG: 00710+3.1.3.11;KEGG: 00010+3.1.3.11;KEGG: 00680+3.1.3.11	"Fructose and mannose metabolism";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)";"Carbon fixation in photosynthetic organisms";"Glycolysis / Gluconeogenesis";"Methane metabolism"
Mdes007464-RC	4	Reactome: R-HSA-6798695;Reactome: R-HSA-6802952;Reactome: R-HSA-1632852;Reactome: R-HSA-983168	"Neutrophil degranulation";"Signaling by BRAF and RAF fusions";"Macroautophagy";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes005323-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Mdes006184-RA	2	Reactome: R-HSA-2206307;Reactome: R-HSA-2024096	"MPS IIIA - Sanfilippo syndrome A";"HS-GAG degradation"
Mdes013776-RA	12	MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis I"
Mdes019806-RA	8	KEGG: 00250+6.3.4.5;MetaCyc: PWY-4983;KEGG: 00220+6.3.4.5;MetaCyc: PWY-4984;MetaCyc: PWY-5;MetaCyc: PWY-7400;Reactome: R-HSA-70635;MetaCyc: PWY-5154	"Alanine, aspartate and glutamate metabolism";"Nitric oxide biosynthesis II (mammals)";"Arginine biosynthesis";"Urea cycle";"Canavanine biosynthesis";"L-arginine biosynthesis IV (archaebacteria)";"Urea cycle";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)"
Mdes002776-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Mdes008020-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Mdes009065-RA	6	Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-456926;Reactome: R-HSA-418592;Reactome: R-HSA-399997;Reactome: R-HSA-428930	"G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"ADP signalling through P2Y purinoceptor 1";"Acetylcholine regulates insulin secretion";"Thromboxane signalling through TP receptor"
Mdes009677-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
Mdes001024-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes015922-RA	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
Mdes000504-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Mdes004141-RA	10	Reactome: R-HSA-72649;Reactome: R-HSA-382556;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-381042;Reactome: R-HSA-9648895;Reactome: R-HSA-72731;Reactome: R-HSA-72695	"Translation initiation complex formation";"ABC-family proteins mediated transport";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"PERK regulates gene expression";"Response of EIF2AK1 (HRI) to heme deficiency";"Recycling of eIF2:GDP";"Formation of the ternary complex, and subsequently, the 43S complex"
Mdes002452-RA	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
Mdes002403-RB	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
Mdes001814-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes011263-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes000404-RA	14	MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-5972;MetaCyc: PWY-7602;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-7724	"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)"
Mdes005034-RA	1	Reactome: R-HSA-480985	"Synthesis of dolichyl-phosphate-glucose"
Mdes006276-RA	1	Reactome: R-HSA-68962	"Activation of the pre-replicative complex"
Mdes007150-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
Mdes010158-RA	4	MetaCyc: PWY-6129;KEGG: 00510+2.7.1.108;Reactome: R-HSA-446199;Reactome: R-HSA-4755583	"Dolichol and dolichyl phosphate biosynthesis";"N-Glycan biosynthesis";"Synthesis of Dolichyl-phosphate";"Defective DOLK causes DOLK-CDG (CDG-1m)"
Mdes000463-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes003988-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Mdes005661-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes019640-RA	7	Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1362277;Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-1538133	"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by DREAM complex";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"G0 and Early G1"
Mdes000593-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Mdes000785-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes011824-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes010052-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-9020702	"Neutrophil degranulation";"Interleukin-1 signaling"
Mdes002867-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Mdes018311-RA	1	KEGG: 00330+3.5.3.23	"Arginine and proline metabolism"
Mdes010585-RB	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
Mdes018288-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450385	"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes013091-RA	5	MetaCyc: PWY-6700;Reactome: R-HSA-6782315;MetaCyc: PWY-8106;Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Queuosine biosynthesis I (de novo)";"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis III (queuosine salvage)";"Hedgehog 'off' state";"Intraflagellar transport"
Mdes011511-RB	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
Mdes002674-RA	7	Reactome: R-HSA-5632684;Reactome: R-HSA-5632681;Reactome: R-HSA-5635838;Reactome: R-HSA-373080;Reactome: R-HSA-5658034;Reactome: R-HSA-5358346;Reactome: R-HSA-5362798	"Hedgehog 'on' state";"Ligand-receptor interactions";"Activation of SMO";"Class B/2 (Secretin family receptors)";"HHAT G278V abrogates palmitoylation of Hh-Np";"Hedgehog ligand biogenesis";"Release of Hh-Np from the secreting cell"
Mdes004301-RA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
Mdes011413-RB	4	Reactome: R-HSA-6782861;MetaCyc: PWY-6829;MetaCyc: PWY-7286;MetaCyc: PWY-7285	"Synthesis of wybutosine at G37 of tRNA(Phe)";"Trna methylation (yeast)";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Methylwyosine biosynthesis"
Mdes005673-RB	5	Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-1257604;Reactome: R-HSA-5674400;Reactome: R-HSA-6804757	"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of TP53 Degradation"
Mdes015723-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes005673-RA	5	Reactome: R-HSA-389357;Reactome: R-HSA-5218920;Reactome: R-HSA-5674400;Reactome: R-HSA-6804757;Reactome: R-HSA-1257604	"CD28 dependent PI3K/Akt signaling";"VEGFR2 mediated vascular permeability";"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of TP53 Degradation";"PIP3 activates AKT signaling"
Mdes014787-RB	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
Mdes019118-RA	5	Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390471;Reactome: R-HSA-6814122;Reactome: R-HSA-390450	"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC"
Mdes006997-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Mdes013417-RA	3	Reactome: R-HSA-2514859;KEGG: 00310+2.1.1.60;Reactome: R-HSA-8876725	"Inactivation, recovery and regulation of the phototransduction cascade";"Lysine degradation";"Protein methylation"
Mdes002389-RA	7	KEGG: 00240+2.7.4.14;MetaCyc: PWY-7219;Reactome: R-HSA-499943;MetaCyc: PWY-7176;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3;KEGG: 00983+2.7.4.14	"Pyrimidine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"UTP and CTP de novo biosynthesis";"Thiamine metabolism";"Purine metabolism";"Drug metabolism - other enzymes"
Mdes005526-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
Mdes004492-RA	1	Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Holliday Junction Intermediates"
Mdes005712-RB	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes009901-RA	4	Reactome: R-HSA-4720454;KEGG: 00510+2.4.1.259+2.4.1.261;KEGG: 00513+2.4.1.261;Reactome: R-HSA-446193	"Defective ALG9 causes ALG9-CDG (CDG-1l)";"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
Mdes006828-RA	20	Reactome: R-HSA-5696397;Reactome: R-HSA-5693616;Reactome: R-HSA-110314;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-110312;Reactome: R-HSA-110320;Reactome: R-HSA-69091;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5656121;Reactome: R-HSA-69473;Reactome: R-HSA-176187;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938;Reactome: R-HSA-5651801	"Gap-filling DNA repair synthesis and ligation in GG-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Recognition of DNA damage by PCNA-containing replication complex";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by REV1";"Translesion Synthesis by POLH";"Polymerase switching";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Translesion synthesis by POLI";"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)";"PCNA-Dependent Long Patch Base Excision Repair"
Mdes020050-RA	16	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-5419276;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Mitochondrial translation termination";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane"
Mdes018281-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes002532-RA	8	Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-3371571;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-166208	"Macroautophagy";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"HSF1-dependent transactivation";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"mTORC1-mediated signalling"
Mdes002680-RA	8	Reactome: R-HSA-113501;Reactome: R-HSA-69183;Reactome: R-HSA-69091;Reactome: R-HSA-174411;Reactome: R-HSA-69166;Reactome: R-HSA-68952;Reactome: R-HSA-174430;Reactome: R-HSA-68962	"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Processive synthesis on the lagging strand";"Polymerase switching";"Polymerase switching on the C-strand of the telomere";"Removal of the Flap Intermediate";"DNA replication initiation";"Telomere C-strand synthesis initiation";"Activation of the pre-replicative complex"
Mdes000003-RA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Mdes004221-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes001375-RA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Mdes002681-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes011914-RB	8	Reactome: R-HSA-432040;Reactome: R-HSA-5610787;Reactome: R-HSA-983231;Reactome: R-HSA-180024;Reactome: R-HSA-381676;Reactome: R-HSA-163615;Reactome: R-HSA-164378;Reactome: R-HSA-442720	"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state";"Factors involved in megakaryocyte development and platelet production";"DARPP-32 events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"PKA activation";"PKA activation in glucagon signalling";"CREB1 phosphorylation through the activation of Adenylate Cyclase"
Mdes002212-RC	5	MetaCyc: PWY-7817;KEGG: 04070+2.7.7.41;MetaCyc: PWY-5667;KEGG: 00564+2.7.7.41;MetaCyc: PWY-5981	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III"
Mdes019883-RA	3	MetaCyc: PWY-7674;MetaCyc: PWY-1269;KEGG: 00540+2.5.1.55	"CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis";"CMP-3-deoxy-D-manno-octulosonate biosynthesis";"Lipopolysaccharide biosynthesis"
Mdes004256-RB	20	Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5656121;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-5685942;Reactome: R-HSA-5651801;Reactome: R-HSA-5685938;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-5693616;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-110320;Reactome: R-HSA-110312;Reactome: R-HSA-69091	"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"Translesion synthesis by POLI";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"HDR through Homologous Recombination (HRR)";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Single Strand Annealing (SSA)";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Presynaptic phase of homologous DNA pairing and strand exchange";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion Synthesis by POLH";"Translesion synthesis by REV1";"Polymerase switching"
Mdes009350-RA	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
Mdes000322-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes000489-RA	8	Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68949;Reactome: R-HSA-68689;Reactome: R-HSA-68962;Reactome: R-HSA-68616;Reactome: R-HSA-176187;Reactome: R-HSA-68867	"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Orc1 removal from chromatin";"CDC6 association with the ORC:origin complex";"Activation of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex"
Mdes000519-RE	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes017383-RA	5	Reactome: R-HSA-983231;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497	"Factors involved in megakaryocyte development and platelet production";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Mdes008750-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes003094-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes010291-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes011016-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes017606-RA	14	Reactome: R-HSA-110320;Reactome: R-HSA-110312;Reactome: R-HSA-69091;Reactome: R-HSA-5685942;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-5696400;Reactome: R-HSA-5655862;Reactome: R-HSA-6782135;Reactome: R-HSA-5656121;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-110314	"Translesion Synthesis by POLH";"Translesion synthesis by REV1";"Polymerase switching";"HDR through Homologous Recombination (HRR)";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual Incision in GG-NER";"Translesion synthesis by POLK";"Dual incision in TC-NER";"Translesion synthesis by POLI";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex"
Mdes015020-RA	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
Mdes011092-RA	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Mdes009539-RE	7	Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-2565942	"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition"
Mdes016342-RA	2	Reactome: R-HSA-110320;Reactome: R-HSA-983168	"Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes007551-RA	7	KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1	"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway"
Mdes000461-RB	2	Reactome: R-HSA-418594;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
Mdes016838-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes019196-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes019138-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes007715-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Mdes006933-RA	7	Reactome: R-HSA-1632852;Reactome: R-HSA-8943724;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-5628897	"Macroautophagy";"Regulation of PTEN gene transcription";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes"
Mdes014653-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes013355-RA	8	MetaCyc: PWY-6580;Reactome: R-HSA-1855183;MetaCyc: PWY-4661;MetaCyc: PWY-6372;MetaCyc: PWY-6664;MetaCyc: PWY-2301;KEGG: 00521+5.5.1.4;KEGG: 00562+5.5.1.4	"Phosphatidylinositol biosynthesis I (bacteria)";"Synthesis of IP2, IP, and Ins in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Di-myo-inositol phosphate biosynthesis";"Myo-inositol biosynthesis";"Streptomycin biosynthesis";"Inositol phosphate metabolism"
Mdes002167-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes003669-RB	12	MetaCyc: PWY-5855;Reactome: R-HSA-2142789;KEGG: 00130+1.14.99.60;MetaCyc: PWY-6708;MetaCyc: PWY-5857;MetaCyc: PWY-5870;MetaCyc: PWY-5856;MetaCyc: PWY-5871;MetaCyc: PWY-5873;MetaCyc: PWY-7230;MetaCyc: PWY-7233;MetaCyc: PWY-5872	"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)"
Mdes019583-RA	4	Reactome: R-HSA-1799339;Reactome: R-HSA-6798695;Reactome: R-HSA-879415;Reactome: R-HSA-446203	"SRP-dependent cotranslational protein targeting to membrane";"Neutrophil degranulation";"Advanced glycosylation endproduct receptor signaling";"Asparagine N-linked glycosylation"
Mdes006175-RA	1	Reactome: R-HSA-1483148	"Synthesis of PG"
Mdes000534-RB	4	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes004349-RB	6	Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-176187	"Orc1 removal from chromatin";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress"
Mdes001235-RA	3	KEGG: 00680+3.1.3.3;Reactome: R-HSA-977347;KEGG: 00260+3.1.3.3	"Methane metabolism";"Serine biosynthesis";"Glycine, serine and threonine metabolism"
Mdes001995-RB	2	MetaCyc: PWY-7511;Reactome: R-HSA-6798695	"Protein ubiquitination";"Neutrophil degranulation"
Mdes015019-RA	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
Mdes010885-RB	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes019405-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes007676-RA	31	MetaCyc: PWY-7858;MetaCyc: PWY-7723;Reactome: R-HSA-2426168;Reactome: R-HSA-9029558;MetaCyc: PWY-4381;MetaCyc: PWY-5989;MetaCyc: PWY-5966-1;MetaCyc: PWY-5367;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;Reactome: R-HSA-163765;Reactome: R-HSA-199220;MetaCyc: PWY-5142;MetaCyc: PWY-5973;MetaCyc: PWY-7664;MetaCyc: PWY-8047;MetaCyc: PWY-8012;Reactome: R-HSA-75105;MetaCyc: PWY-5366;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5994;MetaCyc: PWYG-321;MetaCyc: PWY-7746;MetaCyc: PWY-7663;MetaCyc: PWY-6113;MetaCyc: PWY-7388;MetaCyc: PWY-6799;MetaCyc: PWY-8049;MetaCyc: PWY-6282;MetaCyc: PWY-5971;MetaCyc: PWY-5147;MetaCyc: PWY-6519	"(5Z)-dodecenoate biosynthesis II";"Bacterial bioluminescence";"Activation of gene expression by SREBF (SREBP)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Stearate biosynthesis II (bacteria and plants)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Petroselinate biosynthesis";"Fatty acid biosynthesis";"ChREBP activates metabolic gene expression";"Vitamin B5 (pantothenate) metabolism";"Acyl-[acyl-carrier protein] thioesterase pathway";"Cis-vaccenate biosynthesis";"Oleate biosynthesis IV (anaerobic)";"Bryostatin biosynthesis";"Mupirocin biosynthesis";"Fatty acyl-CoA biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Biotin metabolism";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"";"Mycobacterial sulfolipid biosynthesis";"Gondoate biosynthesis (anaerobic)";"Superpathway of mycolate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Pederin biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis I (plants)";"8-amino-7-oxononanoate biosynthesis I"
Mdes001156-RA	6	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-72163	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway"
Mdes008796-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes012272-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes009218-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
Mdes004427-RA	3	Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429947	"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Deadenylation of mRNA"
Mdes019589-RA	1	MetaCyc: PWY-7802	"N-end rule pathway II (prokaryotic)"
Mdes002483-RA	7	MetaCyc: PWY-5466;MetaCyc: PWY-5469;MetaCyc: PWY-6824;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461;MetaCyc: PWY-7445;MetaCyc: PWY-7214	"Matairesinol biosynthesis";"Sesamin biosynthesis";"Justicidin B biosynthesis";"Phenylpropanoid biosynthesis";"Betanidin degradation";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)"
Mdes002621-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes013043-RA	1	Reactome: R-HSA-525793	"Myogenesis"
Mdes010117-RA	5	Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-917729	"HCMV Late Events";"Budding and maturation of HIV virion";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)"
Mdes005449-RA	2	Reactome: R-HSA-6793080;Reactome: R-HSA-2151201	"rRNA modification in the mitochondrion";"Transcriptional activation of mitochondrial biogenesis"
Mdes005369-RB	2	Reactome: R-HSA-204174;Reactome: R-HSA-5362517	"Regulation of pyruvate dehydrogenase (PDH) complex";"Signaling by Retinoic Acid"
Mdes010836-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes002029-RB	1	Reactome: R-HSA-3295583	"TRP channels"
Mdes014119-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes013041-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes001904-RA	1	KEGG: 00970+6.1.1.22	"Aminoacyl-tRNA biosynthesis"
Mdes009636-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes014279-RA	5	Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-983170;Reactome: R-HSA-204005;Reactome: R-HSA-2132295	"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"COPII-mediated vesicle transport";"MHC class II antigen presentation"
Mdes006837-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes005613-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes008820-RA	3	Reactome: R-HSA-390471;Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Association of TriC/CCT with target proteins during biosynthesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Mdes012334-RA	30	Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-5696400;Reactome: R-HSA-427413;Reactome: R-HSA-167246;Reactome: R-HSA-5696395;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-2564830;Reactome: R-HSA-76042;Reactome: R-HSA-77075;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6781827;Reactome: R-HSA-73772;Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-72086	"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Dual Incision in GG-NER";"NoRC negatively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"Formation of Incision Complex in GG-NER";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"Cytosolic iron-sulfur cluster assembly";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Promoter Escape";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping"
Mdes002509-RB	14	MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-5972;MetaCyc: PWY-7602	"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"
Mdes017794-RA	1	Reactome: R-HSA-381038	"XBP1(S) activates chaperone genes"
Mdes013591-RG	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Mdes007735-RB	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes001720-RA	57	Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-5668541;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-5362768;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-187577;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-450408;Reactome: R-HSA-6798695;Reactome: R-HSA-5687128;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-174154	"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"TNFR2 non-canonical NF-kB pathway";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Neddylation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"SCF(Skp2)-mediated degradation of p27/p21";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neutrophil degranulation";"MAPK6/MAPK4 signaling";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin"
Mdes002067-RA	8	Reactome: R-HSA-69091;Reactome: R-HSA-69183;Reactome: R-HSA-113501;Reactome: R-HSA-174430;Reactome: R-HSA-68952;Reactome: R-HSA-69166;Reactome: R-HSA-174411;Reactome: R-HSA-68962	"Polymerase switching";"Processive synthesis on the lagging strand";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Telomere C-strand synthesis initiation";"DNA replication initiation";"Removal of the Flap Intermediate";"Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex"
Mdes007508-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes016371-RA	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
Mdes001518-RA	4	Reactome: R-HSA-1650814;Reactome: R-HSA-2214320;Reactome: R-HSA-1474228;Reactome: R-HSA-2243919	"Collagen biosynthesis and modifying enzymes";"Anchoring fibril formation";"Degradation of the extracellular matrix";"Crosslinking of collagen fibrils"
Mdes013654-RA	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
Mdes016434-RA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
Mdes005974-RA	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
Mdes007255-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes002061-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes008467-RA	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
Mdes018551-RA	2	KEGG: 00260+1.4.4.2;Reactome: R-HSA-6783984	"Glycine, serine and threonine metabolism";"Glycine degradation"
Mdes013834-RA	1	Reactome: R-HSA-5676934	"Protein repair"
Mdes010119-RA	3	Reactome: R-HSA-3214858;Reactome: R-HSA-191859;Reactome: R-HSA-6804760	"RMTs methylate histone arginines";"snRNP Assembly";"Regulation of TP53 Activity through Methylation"
Mdes011481-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Mdes018303-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes012969-RA	3	MetaCyc: PWY-7546;Reactome: R-HSA-5358493;MetaCyc: PWY-6482	"Diphthamide biosynthesis II (eukaryotes)";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)"
Mdes006184-RC	2	Reactome: R-HSA-2206307;Reactome: R-HSA-2024096	"MPS IIIA - Sanfilippo syndrome A";"HS-GAG degradation"
Mdes004956-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes000604-RA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
Mdes005278-RB	4	Reactome: R-HSA-947581;Reactome: R-HSA-209968;KEGG: 00790+2.8.1.9;MetaCyc: PWY-5963	"Molybdenum cofactor biosynthesis";"Thyroxine biosynthesis";"Folate biosynthesis";"Thio-molybdenum cofactor biosynthesis"
Mdes012723-RB	2	Reactome: R-HSA-6784531;Reactome: R-HSA-1268020	"tRNA processing in the nucleus";"Mitochondrial protein import"
Mdes019564-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes002176-RA	6	Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-6798695;Reactome: R-HSA-1222556	"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"Transferrin endocytosis and recycling";"Neutrophil degranulation";"ROS and RNS production in phagocytes"
Mdes002889-RB	2	Reactome: R-HSA-174403;Reactome: R-HSA-5578999	"Glutathione synthesis and recycling";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)"
Mdes007888-RA	1	MetaCyc: PWY-6938	"NADH repair"
Mdes004212-RA	15	Reactome: R-HSA-167242;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167158;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167200;Reactome: R-HSA-167243	"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery"
Mdes015960-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes013641-RB	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
Mdes019682-RA	2	KEGG: 00520+2.3.1.157+2.7.7.23;MetaCyc: PWY-5514	"Amino sugar and nucleotide sugar metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis II"
Mdes006259-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes014755-RA	10	KEGG: 00531+3.2.1.23;KEGG: 00600+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2160916;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2206292;Reactome: R-HSA-2024096	"Glycosaminoglycan degradation";"Sphingolipid metabolism";"Neutrophil degranulation";"Galactose metabolism";"Other glycan degradation";"Hyaluronan uptake and degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"MPS VII - Sly syndrome";"HS-GAG degradation"
Mdes011595-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes001238-RA	3	Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-5689877	"DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"Josephin domain DUBs"
Mdes001395-RA	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
Mdes000065-RA	3	Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism"
Mdes001642-RA	1	Reactome: R-HSA-5689603	"UCH proteinases"
Mdes000667-RA	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
Mdes008558-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes006767-RA	18	KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925;MetaCyc: PWY-8053;MetaCyc: PWY-7417;Reactome: R-HSA-1482922;MetaCyc: PWY-8051;MetaCyc: PWY-7409;Reactome: R-HSA-1482801;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482839	"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PI";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PS";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Arachidonic acid metabolism";"Acyl chain remodelling of PE"
Mdes005663-RA	13	Reactome: R-HSA-4086398;Reactome: R-HSA-983695;Reactome: R-HSA-381676;Reactome: R-HSA-112043;Reactome: R-HSA-5578775;Reactome: R-HSA-5218921;Reactome: R-HSA-1489509;Reactome: R-HSA-5607763;Reactome: R-HSA-2029485;Reactome: R-HSA-114508;Reactome: R-HSA-139853;Reactome: R-HSA-422356;Reactome: R-HSA-2871809	"Ca2+ pathway";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"PLC beta mediated events";"Ion homeostasis";"VEGFR2 mediated cell proliferation";"DAG and IP3 signaling";"CLEC7A (Dectin-1) induces NFAT activation";"Role of phospholipids in phagocytosis";"Effects of PIP2 hydrolysis";"Elevation of cytosolic Ca2+ levels";"Regulation of insulin secretion";"FCERI mediated Ca+2 mobilization"
Mdes005712-RD	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes005512-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Mdes001339-RB	14	MetaCyc: PWY-7587;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-7411;MetaCyc: PWY-7417;MetaCyc: PWY-7782;MetaCyc: PWY-8055;MetaCyc: PWY-5667;MetaCyc: PWY-7589;KEGG: 00561+2.3.1.51;Reactome: R-HSA-1483166;KEGG: 00564+2.3.1.51	"Oleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Phosphatidate biosynthesis (yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Plasmalogen biosynthesis";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Palmitoleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Synthesis of PA";"Glycerophospholipid metabolism"
Mdes016669-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes001748-RA	1	Reactome: R-HSA-5617472	"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
Mdes001938-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes007402-RB	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes006364-RB	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Mdes009331-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes001958-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Mdes012337-RA	5	Reactome: R-HSA-75035;Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-5625740	"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate PKNs"
Mdes018361-RA	3	KEGG: 00970+6.3.5.7;KEGG: 00791+3.5.1.131;MetaCyc: PWY-8025	"Aminoacyl-tRNA biosynthesis";"Atrazine degradation";"Cyanuric acid degradation I"
Mdes000748-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes018747-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes009518-RA	11	MetaCyc: PWY-3881;Reactome: R-HSA-4043916;KEGG: 00520+5.3.1.8;MetaCyc: PWY-7456;Reactome: R-HSA-446205;MetaCyc: PWY-6992;KEGG: 00051+5.3.1.8;MetaCyc: PWY-3861;MetaCyc: PWY-882;MetaCyc: PWY-7586;MetaCyc: PWY-5659	"Mannitol biosynthesis";"Defective MPI causes MPI-CDG (CDG-1b)";"Amino sugar and nucleotide sugar metabolism";"Beta-(1,4)-mannan degradation";"Synthesis of GDP-mannose";"1,5-anhydrofructose degradation";"Fructose and mannose metabolism";"Mannitol degradation II";"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"GDP-mannose biosynthesis"
Mdes000564-RA	3	Reactome: R-HSA-381426;Reactome: R-HSA-5362798;Reactome: R-HSA-8957275	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Release of Hh-Np from the secreting cell";"Post-translational protein phosphorylation"
Mdes001419-RA	5	Reactome: R-HSA-174490;Reactome: R-HSA-162588;Reactome: R-HSA-9610379;Reactome: R-HSA-917729;Reactome: R-HSA-9615710	"Membrane binding and targetting of GAG proteins";"Budding and maturation of HIV virion";"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy"
Mdes002687-RA	3	Reactome: R-HSA-73843;KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"5-Phosphoribose 1-diphosphate biosynthesis";"Pentose phosphate pathway";"Purine metabolism"
Mdes000346-RA	6	KEGG: 04070+3.1.3.64;Reactome: R-HSA-1660517;KEGG: 00562+3.1.3.64;Reactome: R-HSA-1855183;MetaCyc: PWY-6368;MetaCyc: PWY-6580	"Phosphatidylinositol signaling system";"Synthesis of PIPs at the late endosome membrane";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"3-phosphoinositide degradation";"Phosphatidylinositol biosynthesis I (bacteria)"
Mdes004197-RA	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
Mdes016231-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes006314-RA	1	Reactome: R-HSA-8876725	"Protein methylation"
Mdes007649-RA	9	Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-73776	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape"
Mdes007605-RB	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Mdes013247-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes014822-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Mdes010585-RC	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
Mdes002661-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-6784531;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"tRNA processing in the nucleus";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Mdes006162-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Mdes001540-RA	9	Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-73779	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
Mdes014362-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Mdes006916-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Mdes001099-RA	5	Reactome: R-HSA-390450;Reactome: R-HSA-6814122;Reactome: R-HSA-390471;Reactome: R-HSA-389957;Reactome: R-HSA-389960	"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Association of TriC/CCT with target proteins during biosynthesis";"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC"
Mdes001390-RA	3	Reactome: R-HSA-189451;MetaCyc: PWY-7159;KEGG: 00860+1.3.3.4	"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism"
Mdes006617-RB	2	Reactome: R-HSA-1799339;Reactome: R-HSA-381038	"SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes"
Mdes012488-RA	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
Mdes009268-RA	2	KEGG: 00970+6.1.1.1;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
Mdes010888-RA	3	Reactome: R-HSA-5655862;Reactome: R-HSA-110312;Reactome: R-HSA-5656121	"Translesion synthesis by POLK";"Translesion synthesis by REV1";"Translesion synthesis by POLI"
Mdes016701-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes011822-RA	4	Reactome: R-HSA-2395516;Reactome: R-HSA-196108;Reactome: R-HSA-211976;Reactome: R-HSA-5579026	"Electron transport from NADPH to Ferredoxin";"Pregnenolone biosynthesis";"Endogenous sterols";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"
Mdes017984-RA	7	KEGG: 00051+3.1.3.11;KEGG: 00030+3.1.3.11;MetaCyc: PWY-5484;Reactome: R-HSA-70263;KEGG: 00010+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11	"Fructose and mannose metabolism";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)";"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Methane metabolism"
Mdes000288-RA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
Mdes012709-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes010245-RA	26	Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-2408557;Reactome: R-HSA-6802952;Reactome: R-HSA-6802948;KEGG: 04926+2.7.11.1;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-5674135;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-6802955;Reactome: R-HSA-72764;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9649948;Reactome: R-HSA-6802946;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"mTOR signaling pathway";"Human papillomavirus infection";"Selenocysteine synthesis";"Signaling by BRAF and RAF fusions";"Signaling by high-kinase activity BRAF mutants";"Relaxin signaling pathway";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"MAP2K and MAPK activation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Eukaryotic Translation Termination";"Thermogenesis";"Human cytomegalovirus infection";"Signaling downstream of RAS mutants";"Signaling by moderate kinase activity BRAF mutants";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes002986-RB	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes018702-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Mdes000787-RC	70	Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-73780;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;MetaCyc: PWY-6344;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-1834949;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;MetaCyc: PWY-3341;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-5607764;Reactome: R-HSA-76066;Reactome: R-HSA-8941858;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-5610783;Reactome: R-HSA-8964539;Reactome: R-HSA-68949;Reactome: R-HSA-5689603;Reactome: R-HSA-73980;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-532668;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-4641257;Reactome: R-HSA-180585;Reactome: R-HSA-5668541;Reactome: R-HSA-9604323;Reactome: R-HSA-8852276;Reactome: R-HSA-174154;KEGG: 00330+2.6.1.13;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-69481;Reactome: R-HSA-211733;Reactome: R-HSA-69601;MetaCyc: PWY-6922;Reactome: R-HSA-195253;MetaCyc: PWY-4981;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-187577	"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"RNA Polymerase III Chain Elongation";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"L-ornithine degradation II (Stickland reaction)";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Cytosolic sensors of pathogen-associated DNA";"Neddylation";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"L-proline biosynthesis III (from L-ornithine)";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CLEC7A (Dectin-1) signaling";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Regulation of RUNX3 expression and activity";"Ub-specific processing proteases";"Hedgehog 'on' state";"Degradation of GLI2 by the proteasome";"Glutamate and glutamine metabolism";"Orc1 removal from chromatin";"UCH proteinases";"RNA Polymerase III Transcription Termination";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Degradation of AXIN";"Vif-mediated degradation of APOBEC3G";"TNFR2 non-canonical NF-kB pathway";"Negative regulation of NOTCH4 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdc20 mediated degradation of Securin";"Arginine and proline metabolism";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"G2/M Checkpoints";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"L-Ndelta-acetylornithine biosynthesis";"Degradation of beta-catenin by the destruction complex";"L-proline biosynthesis II (from arginine)";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21"
Mdes002325-RA	3	MetaCyc: PWY-7807;KEGG: 00190+3.6.1.1;MetaCyc: PWY-7805	"Glyphosate degradation III";"Oxidative phosphorylation";"(aminomethyl)phosphonate degradation"
Mdes003320-RA	4	Reactome: R-HSA-72086;MetaCyc: PWY-7375;Reactome: R-HSA-77075;Reactome: R-HSA-167160	"mRNA Capping";"Mrna capping I";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection"
Mdes019189-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes009479-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes019587-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8949613	"Mitochondrial protein import";"Cristae formation"
Mdes019442-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes001339-RA	14	MetaCyc: PWY-7417;MetaCyc: PWY-7782;MetaCyc: PWY-7411;MetaCyc: PWY-8053;MetaCyc: PWY-5981;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-7587;KEGG: 00564+2.3.1.51;Reactome: R-HSA-1483166;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7589;MetaCyc: PWY-5667;MetaCyc: PWY-8055	"Phospholipid remodeling (phosphatidate, yeast)";"Plasmalogen biosynthesis";"Phosphatidate biosynthesis (yeast)";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis III";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Glycerophospholipid metabolism";"Synthesis of PA";"Glycerolipid metabolism";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis"
Mdes005006-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes009238-RA	15	Reactome: R-HSA-426486;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-9022692;Reactome: R-HSA-194840;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-1912408;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-203927	"Small interfering RNA (siRNA) biogenesis";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of MECP2 expression and activity";"Rho GTPase cycle";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Pre-NOTCH Transcription and Translation";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"MicroRNA (miRNA) biogenesis"
Mdes006377-RA	9	Reactome: R-HSA-975634;Reactome: R-HSA-1971475;Reactome: R-HSA-3560801;Reactome: R-HSA-4420332;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253;Reactome: R-HSA-3560783;Reactome: R-HSA-2024096	"Retinoid metabolism and transport";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GAT3 causes JDSSDHD";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective B4GALT7 causes EDS, progeroid type";"HS-GAG degradation"
Mdes012002-RD	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes005992-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes004988-RB	4	Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
Mdes001662-RA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Mdes005175-RA	3	Reactome: R-HSA-6807004;Reactome: R-HSA-202427;Reactome: R-HSA-6798695	"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation"
Mdes002592-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes007874-RA	2	KEGG: 00052+3.2.1.26;KEGG: 00500+3.2.1.26	"Galactose metabolism";"Starch and sucrose metabolism"
Mdes005485-RB	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902	"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation"
Mdes020013-RA	1	Reactome: R-HSA-110357	"Displacement of DNA glycosylase by APEX1"
Mdes008933-RA	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
Mdes015933-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes000938-RA	6	MetaCyc: PWY-7346;Reactome: R-HSA-173599;MetaCyc: PWY-7820;KEGG: 00040+1.1.1.22;KEGG: 00053+1.1.1.22;KEGG: 00520+1.1.1.22	"UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)";"Formation of the active cofactor, UDP-glucuronate";"Teichuronic acid biosynthesis (B. subtilis 168)";"Pentose and glucuronate interconversions";"Ascorbate and aldarate metabolism";"Amino sugar and nucleotide sugar metabolism"
Mdes008922-RA	2	KEGG: 00970+6.1.1.4;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
Mdes009257-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Mdes019575-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Mdes009781-RA	8	Reactome: R-HSA-182218;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-167590;Reactome: R-HSA-9639288;Reactome: R-HSA-9636467	"Nef Mediated CD8 Down-regulation";"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Nef Mediated CD4 Down-regulation";"Amino acids regulate mTORC1";"Blockage of phagosome acidification"
Mdes003310-RA	3	MetaCyc: PWY-7159;Reactome: R-HSA-189451;KEGG: 00860+1.3.3.3	"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
Mdes012340-RA	2	Reactome: R-HSA-3065676;Reactome: R-HSA-3065678	"SUMO is conjugated to E1 (UBA2:SAE1)";"SUMO is transferred from E1 to E2 (UBE2I, UBC9)"
Mdes009754-RA	6	Reactome: R-HSA-159236;Reactome: R-HSA-975957;Reactome: R-HSA-72163;Reactome: R-HSA-9010553;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA Splicing - Major Pathway";"Regulation of expression of SLITs and ROBOs";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes009581-RB	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Mdes019747-RA	4	Reactome: R-HSA-6787450;MetaCyc: PWY-2781;KEGG: 00908+2.5.1.75;Reactome: R-HSA-6782315	"tRNA modification in the mitochondrion";"Cis-zeatin biosynthesis";"Zeatin biosynthesis";"tRNA modification in the nucleus and cytosol"
Mdes002070-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes001404-RB	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Mdes002518-RA	3	Reactome: R-HSA-6811434;Reactome: R-HSA-390471;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis";"Kinesins"
Mdes007101-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Mdes000195-RA	5	Reactome: R-HSA-8856828;Reactome: R-HSA-432722;Reactome: R-HSA-8856825;Reactome: R-HSA-6811440;Reactome: R-HSA-6798695	"Clathrin-mediated endocytosis";"Golgi Associated Vesicle Biogenesis";"Cargo recognition for clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network";"Neutrophil degranulation"
Mdes010428-RA	4	Reactome: R-HSA-8856828;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-3928662	"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling"
Mdes007434-RA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Mdes007327-RA	3	Reactome: R-HSA-156590;MetaCyc: PWY-1801;KEGG: 00680+3.1.2.12	"Glutathione conjugation";"Formaldehyde oxidation II (glutathione-dependent)";"Methane metabolism"
Mdes004411-RC	2	Reactome: R-HSA-6783310;Reactome: R-HSA-6796648	"Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes"
Mdes002542-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes005669-RA	3	Reactome: R-HSA-1268020;Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Mitochondrial protein import";"Respiratory electron transport";"Complex I biogenesis"
Mdes003690-RA	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Mdes010671-RA	5	Reactome: R-HSA-8876198;Reactome: R-HSA-1660499;Reactome: R-HSA-8873719;Reactome: R-HSA-1445148;Reactome: R-HSA-6798695	"RAB GEFs exchange GTP for GDP on RABs";"Synthesis of PIPs at the plasma membrane";"RAB geranylgeranylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Neutrophil degranulation"
Mdes020049-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Mdes016210-RA	29	Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-76042;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-77075;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-5696395;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-427413;Reactome: R-HSA-5696400;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-674695;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-6781827;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-6781823	"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Formation of Incision Complex in GG-NER";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"NoRC negatively regulates rRNA expression";"Dual Incision in GG-NER";"HIV Transcription Initiation";"Dual incision in TC-NER";"RNA Polymerase II Pre-transcription Events";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex"
Mdes002463-RA	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
Mdes013079-RA	4	Reactome: R-HSA-381033;Reactome: R-HSA-8963889;Reactome: R-HSA-8874211;Reactome: R-HSA-1655829	"ATF6 (ATF6-alpha) activates chaperones";"Assembly of active LPL and LIPC lipase complexes";"CREB3 factors activate genes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
Mdes007265-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes001609-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Mdes001384-RA	2	Reactome: R-HSA-5694530;Reactome: R-HSA-204005	"Cargo concentration in the ER";"COPII-mediated vesicle transport"
Mdes009224-RA	1	Reactome: R-HSA-71064	"Lysine catabolism"
Mdes009228-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes018651-RA	6	MetaCyc: PWY-7342;KEGG: 00760+1.4.3.16;MetaCyc: PWY-5316;Reactome: R-HSA-611105;KEGG: 00250+1.4.3.16;Reactome: R-HSA-71403	"Superpathway of nicotine biosynthesis";"Nicotinate and nicotinamide metabolism";"Nicotine biosynthesis";"Respiratory electron transport";"Alanine, aspartate and glutamate metabolism";"Citric acid cycle (TCA cycle)"
Mdes006641-RA	15	Reactome: R-HSA-4086398;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-8936459;Reactome: R-HSA-5628897;Reactome: R-HSA-8986944;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-2559580	"Ca2+ pathway";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by MECP2";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Oxidative Stress Induced Senescence"
Mdes005712-RC	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes003842-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Mdes002246-RA	52	Reactome: R-HSA-1834949;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-72203;Reactome: R-HSA-203927;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-5617472;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-427413;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-76071;Reactome: R-HSA-167238;Reactome: R-HSA-72163;Reactome: R-HSA-9018519;Reactome: R-HSA-77075;Reactome: R-HSA-167242;Reactome: R-HSA-5250924;Reactome: R-HSA-167287;Reactome: R-HSA-73780;Reactome: R-HSA-8851708;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6803529;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-73980;Reactome: R-HSA-167290;Reactome: R-HSA-76066;Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-5578749;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-72165;Reactome: R-HSA-73779;Reactome: R-HSA-5601884;Reactome: R-HSA-6796648	"Cytosolic sensors of pathogen-associated DNA";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Processing of Capped Intron-Containing Pre-mRNA";"MicroRNA (miRNA) biogenesis";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Viral Messenger RNA Synthesis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"NoRC negatively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Major Pathway";"Estrogen-dependent gene expression";"RNA Pol II CTD phosphorylation and interaction with CE";"Abortive elongation of HIV-1 transcript in the absence of Tat";"B-WICH complex positively regulates rRNA expression";"HIV elongation arrest and recovery";"RNA Polymerase III Chain Elongation";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"FGFR2 alternative splicing";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Dual incision in TC-NER";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase III Transcription Termination";"Pausing and recovery of HIV elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Transcriptional regulation by small RNAs";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"PIWI-interacting RNA (piRNA) biogenesis";"TP53 Regulates Transcription of DNA Repair Genes"
Mdes011040-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-5689880	"Mitochondrial calcium ion transport";"Ub-specific processing proteases"
Mdes016064-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Mdes010101-RA	6	Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids"
Mdes012976-RB	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes019767-RA	1	KEGG: 00350+5.3.3.10	"Tyrosine metabolism"
Mdes006081-RA	25	Reactome: R-HSA-9616222;Reactome: R-HSA-8941284;Reactome: R-HSA-8931987;Reactome: R-HSA-8939245;Reactome: R-HSA-8939247;Reactome: R-HSA-8877330;Reactome: R-HSA-8939242;Reactome: R-HSA-8941333;Reactome: R-HSA-8949275;Reactome: R-HSA-8941332;Reactome: R-HSA-8939246;Reactome: R-HSA-8951911;Reactome: R-HSA-8941326;Reactome: R-HSA-8951936;Reactome: R-HSA-8941858;Reactome: R-HSA-8936459;Reactome: R-HSA-8940973;Reactome: R-HSA-8935964;Reactome: R-HSA-8939902;Reactome: R-HSA-8939236;Reactome: R-HSA-9018519;Reactome: R-HSA-8939256;Reactome: R-HSA-8878166;Reactome: R-HSA-8939243;Reactome: R-HSA-8934593	"Transcriptional regulation of granulopoiesis";"RUNX2 regulates chondrocyte maturation";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX2 regulates genes involved in cell migration";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX3 regulates RUNX1-mediated transcription";"RUNX2 regulates bone development";"RUNX3 regulates p14-ARF";"Regulation of RUNX3 expression and activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates expression of components of tight junctions";"Regulation of RUNX2 expression and activity";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in WNT signaling";"Transcriptional regulation by RUNX2";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Regulation of RUNX1 Expression and Activity"
Mdes001256-RA	24	Reactome: R-HSA-456926;Reactome: R-HSA-418217;Reactome: R-HSA-500657;Reactome: R-HSA-202040;Reactome: R-HSA-381676;Reactome: R-HSA-428930;Reactome: R-HSA-4086398;Reactome: R-HSA-418592;Reactome: R-HSA-8964616;Reactome: R-HSA-9009391;Reactome: R-HSA-418597;Reactome: R-HSA-416482;Reactome: R-HSA-6814122;Reactome: R-HSA-8964315;Reactome: R-HSA-420092;Reactome: R-HSA-392170;Reactome: R-HSA-400042;Reactome: R-HSA-416476;Reactome: R-HSA-163359;Reactome: R-HSA-432040;Reactome: R-HSA-392451;Reactome: R-HSA-418594;Reactome: R-HSA-392851;Reactome: R-HSA-418555	"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through PLC beta";"Presynaptic function of Kainate receptors";"G-protein activation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Thromboxane signalling through TP receptor";"Ca2+ pathway";"ADP signalling through P2Y purinoceptor 1";"G beta:gamma signalling through CDC42";"Extra-nuclear estrogen signaling";"G alpha (z) signalling events";"G alpha (12/13) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through BTK";"Glucagon-type ligand receptors";"ADP signalling through P2Y purinoceptor 12";"Adrenaline,noradrenaline inhibits insulin secretion";"G alpha (q) signalling events";"Glucagon signaling in metabolic regulation";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through PI3Kgamma";"G alpha (i) signalling events";"Prostacyclin signalling through prostacyclin receptor";"G alpha (s) signalling events"
Mdes001289-RA	4	Reactome: R-HSA-5368286;Reactome: R-HSA-1483166;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Synthesis of PA";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes000646-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes014478-RA	13	KEGG: 00770+3.6.1.9;MetaCyc: PWY-7206;KEGG: 00500+3.6.1.9;KEGG: 00760+3.6.1.9;MetaCyc: PWY-7184;MetaCyc: PWY-7821;KEGG: 00740+3.6.1.9;Reactome: R-HSA-74259;MetaCyc: PWY-7187;MetaCyc: PWY-6545;KEGG: 00240+3.6.1.9;KEGG: 00230+3.6.1.9;KEGG: 00230+3.6.1.66	"Pantothenate and CoA biosynthesis";"Pyrimidine deoxyribonucleotides dephosphorylation";"Starch and sucrose metabolism";"Nicotinate and nicotinamide metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Tunicamycin biosynthesis";"Riboflavin metabolism";"Purine catabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Purine metabolism";"Purine metabolism"
Mdes003284-RA	5	KEGG: 00270+6.3.2.3;Reactome: R-HSA-174403;MetaCyc: PWY-8043;Reactome: R-HSA-5579006;KEGG: 00480+6.3.2.3	"Cysteine and methionine metabolism";"Glutathione synthesis and recycling";"Ophthalmate biosynthesis";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Glutathione metabolism"
Mdes006885-RB	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes008303-RA	9	MetaCyc: PWY-5663;MetaCyc: PWY-7852;KEGG: 00790+3.5.4.16;MetaCyc: PWY-7442;MetaCyc: PWY-6703;Reactome: R-HSA-1474151;MetaCyc: PWY-5664;MetaCyc: PWY-6147;MetaCyc: PWY-6983	"Erythro-tetrahydrobiopterin biosynthesis I";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Preq0 biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis II";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Threo-tetrahydrobiopterin biosynthesis"
Mdes003242-RC	8	KEGG: 00514+2.4.1.109;Reactome: R-HSA-5083633;MetaCyc: PWY-7979;Reactome: R-HSA-5173105;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083629;MetaCyc: PWY-7921;MetaCyc: PWY-7922	"Other types of O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation III (mammals, core M3)";"O-linked glycosylation";"Mannose type O-glycan biosynthesis";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)"
Mdes002733-RB	2	Reactome: R-HSA-5205685;Reactome: R-HSA-1268020	"Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import"
Mdes001075-RA	33	Reactome: R-HSA-168333;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-141444;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;Reactome: R-HSA-2467813;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-3108214;Reactome: R-HSA-5663220;Reactome: R-HSA-4551638;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-4085377;Reactome: R-HSA-180746;Reactome: R-HSA-180910;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-159236;Reactome: R-HSA-168271	"NEP/NS2 Interacts with the Cellular Export Machinery";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"ISG15 antiviral mechanism";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"Separation of Sister Chromatids";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA damage response and repair proteins";"RHO GTPases Activate Formins";"SUMOylation of chromatin organization proteins";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of SUMOylation proteins";"Nuclear import of Rev protein";"Vpr-mediated nuclear import of PICs";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus"
Mdes010971-RC	5	Reactome: R-HSA-164843;Reactome: R-HSA-5693571;Reactome: R-HSA-6798695;Reactome: R-HSA-1834949;Reactome: R-HSA-3270619	"2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)";"Neutrophil degranulation";"Cytosolic sensors of pathogen-associated DNA";"IRF3-mediated induction of type I IFN"
Mdes012184-RA	7	Reactome: R-HSA-69202;Reactome: R-HSA-156711;Reactome: R-HSA-1362277;Reactome: R-HSA-1362300;Reactome: R-HSA-69656;Reactome: R-HSA-69205;Reactome: R-HSA-1538133	"Cyclin E associated events during G1/S transition";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by DREAM complex";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin A:Cdk2-associated events at S phase entry";"G1/S-Specific Transcription";"G0 and Early G1"
Mdes009952-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes011866-RA	1	Reactome: R-HSA-8943724	"Regulation of PTEN gene transcription"
Mdes017021-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes002728-RA	22	Reactome: R-HSA-73776;Reactome: R-HSA-75953;KEGG: 00513+3.2.1.52;Reactome: R-HSA-76042;Reactome: R-HSA-167172;KEGG: 00511+3.2.1.52;Reactome: R-HSA-73779;KEGG: 00604+3.2.1.52;Reactome: R-HSA-167162;MetaCyc: PWY-7883;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;MetaCyc: PWY-7822;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-6902;Reactome: R-HSA-6807505;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-167161;KEGG: 00603+3.2.1.52;Reactome: R-HSA-674695	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Various types of N-glycan biosynthesis";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"Other glycan degradation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Glycosphingolipid biosynthesis - ganglio series";"RNA Polymerase II HIV Promoter Escape";"Anhydromuropeptides recycling II";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Chitin degradation III (Serratia)";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation";"Chitin degradation II (Vibrio)";"RNA polymerase II transcribes snRNA genes";"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"HIV Transcription Initiation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"RNA Polymerase II Pre-transcription Events"
Mdes010328-RA	3	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-6807505	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes"
Mdes009266-RA	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
Mdes001793-RA	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
Mdes007170-RA	3	Reactome: R-HSA-5628897;Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"TP53 Regulates Metabolic Genes";"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Mdes004102-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes014688-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Mdes010272-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes012002-RA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes017653-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes014960-RB	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
Mdes019601-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes016027-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes012027-RA	13	Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes000404-RB	14	MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7725;MetaCyc: PWY-6433;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-8041;Reactome: R-HSA-75876;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7035;MetaCyc: PWY-6598	"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis"
Mdes009970-RA	1	Reactome: R-HSA-71288	"Creatine metabolism"
Mdes006798-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Mdes001749-RA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
Mdes010676-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes014991-RA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Mdes008342-RA	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
Mdes013215-RC	42	KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.35;KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-7094;MetaCyc: PWY-7726;MetaCyc: PWY-5789;KEGG: 00410+4.2.1.17;KEGG: 00627+4.2.1.17;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-6945;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6946;KEGG: 00623+1.1.1.35;MetaCyc: PWY-6583;MetaCyc: PWY-7401;MetaCyc: PWY-5109;MetaCyc: PWY-6883;MetaCyc: PWY-7656;MetaCyc: PWY-7606;MetaCyc: PWY-5138;MetaCyc: PWY-6944;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;KEGG: 00640+4.2.1.17;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00592+4.2.1.17;MetaCyc: PWY-5136;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;MetaCyc: PWY-7007;MetaCyc: PWY-6863;MetaCyc: PWY-7216;MetaCyc: PWY-5177;MetaCyc: PWY-7654	"Benzoate degradation";"Fatty acid degradation";"Carbon fixation pathways in prokaryotes";"Valine, leucine and isoleucine degradation";"Benzoyl-coa degradation I (aerobic)";"Tryptophan metabolism";"2-methylpropene degradation";"Fatty acid salvage";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"beta-Alanine metabolism";"Aminobenzoate degradation";"Butanoate metabolism";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Limonene and pinene degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Toluene degradation";"Pyruvate fermentation to butanol I";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Fermentation to 2-methylbutanoate";"Pyruvate fermentation to butanol II (engineered)";"Spodoptera littoralis pheromone biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Androstenedione degradation";"Caprolactam degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Butanoate metabolism";"Methyl tert-butyl ether degradation";"Propanoate metabolism";"Lysine degradation";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Geraniol degradation";"Fatty acid degradation";"Fatty acid elongation";"Phenylalanine metabolism";"Methyl ketone biosynthesis (engineered)";"Pyruvate fermentation to hexanol (engineered)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Glutaryl-coa degradation";"(8E,10E)-dodeca-8,10-dienol biosynthesis"
Mdes014061-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes012976-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes006184-RB	2	Reactome: R-HSA-2206307;Reactome: R-HSA-2024096	"MPS IIIA - Sanfilippo syndrome A";"HS-GAG degradation"
Mdes012339-RA	5	Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-3214815;Reactome: R-HSA-350054;Reactome: R-HSA-2122947	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"HDACs deacetylate histones";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription"
Mdes002480-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Mdes005215-RA	7	KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
Mdes003380-RA	5	Reactome: R-HSA-8856828;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-3928662;Reactome: R-HSA-6798695	"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling";"Neutrophil degranulation"
Mdes016282-RA	2	Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13	"Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system"
Mdes017305-RA	6	MetaCyc: PWY-7656;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
Mdes001952-RB	2	Reactome: R-HSA-163560;Reactome: R-HSA-6807505	"Triglyceride catabolism";"RNA polymerase II transcribes snRNA genes"
Mdes010309-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes002095-RA	31	MetaCyc: PWY-5366;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-75105;MetaCyc: PWY-7746;MetaCyc: PWY-7663;MetaCyc: PWY-5994;MetaCyc: PWYG-321;MetaCyc: PWY-7388;MetaCyc: PWY-6113;MetaCyc: PWY-5147;MetaCyc: PWY-5971;MetaCyc: PWY-6519;MetaCyc: PWY-8049;MetaCyc: PWY-6799;MetaCyc: PWY-6282;Reactome: R-HSA-2426168;MetaCyc: PWY-7723;MetaCyc: PWY-7858;MetaCyc: PWY-4381;MetaCyc: PWY-5989;Reactome: R-HSA-9029558;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;Reactome: R-HSA-199220;Reactome: R-HSA-163765;MetaCyc: PWY-5973;MetaCyc: PWY-5142;MetaCyc: PWY-5367;MetaCyc: PWY-5966-1;MetaCyc: PWY-8047;MetaCyc: PWY-7664;MetaCyc: PWY-8012	"Palmitoleate biosynthesis II (plants and bacteria)";"Biotin metabolism";"Fatty acyl-CoA biosynthesis";"Mycobacterial sulfolipid biosynthesis";"Gondoate biosynthesis (anaerobic)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Superpathway of mycolate biosynthesis";"Oleate biosynthesis I (plants)";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"8-amino-7-oxononanoate biosynthesis I";"Pederin biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Activation of gene expression by SREBF (SREBP)";"Bacterial bioluminescence";"(5Z)-dodecenoate biosynthesis II";"Fatty acid biosynthesis initiation (bacteria and plants)";"Stearate biosynthesis II (bacteria and plants)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acid biosynthesis";"Vitamin B5 (pantothenate) metabolism";"ChREBP activates metabolic gene expression";"Cis-vaccenate biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Bryostatin biosynthesis";"Oleate biosynthesis IV (anaerobic)";"Mupirocin biosynthesis"
Mdes007466-RA	6	KEGG: 00730+2.7.6.2;MetaCyc: PWY-6907;MetaCyc: PWY-6898;Reactome: R-HSA-196819;MetaCyc: PWY-7356;MetaCyc: PWY-6908	"Thiamine metabolism";"Thiamine diphosphate biosynthesis III (Staphylococcus)";"Thiamine salvage III";"Vitamin B1 (thiamin) metabolism";"Thiamine salvage IV (yeast)";"Thiamine diphosphate biosynthesis IV (eukaryotes)"
Mdes000421-RB	5	Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-73772;Reactome: R-HSA-427413;Reactome: R-HSA-5250924	"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression"
Mdes015397-RA	18	KEGG: 00983+2.7.4.6;MetaCyc: PWY-7176;MetaCyc: PWY-7184;Reactome: R-HSA-499943;MetaCyc: PWY-7227;MetaCyc: PWY-7221;MetaCyc: PWY-7224;MetaCyc: PWY-7220;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7226;MetaCyc: PWY-7187;MetaCyc: PWY-6545;MetaCyc: PWY-7205;MetaCyc: PWY-7210;MetaCyc: PWY-7222;MetaCyc: PWY-7198;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7197	"Drug metabolism - other enzymes";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Purine deoxyribonucleosides salvage";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"CMP phosphorylation";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotide phosphorylation"
Mdes001392-RA	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
Mdes011950-RC	3	MetaCyc: PWY-7420;Reactome: R-HSA-426048;KEGG: 00561+3.1.1.23	"Monoacylglycerol metabolism (yeast)";"Arachidonate production from DAG";"Glycerolipid metabolism"
Mdes004376-RA	2	Reactome: R-HSA-426486;Reactome: R-HSA-203927	"Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis"
Mdes008250-RA	14	Reactome: R-HSA-975634;MetaCyc: PWY-6803;Reactome: R-HSA-1482788;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7417;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4	"Retinoid metabolism and transport";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PC";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Arachidonic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Linoleic acid metabolism"
Mdes005286-RB	10	Reactome: R-HSA-167172;Reactome: R-HSA-3214847;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-167162;Reactome: R-HSA-674695;Reactome: R-HSA-75953;Reactome: R-HSA-73776	"Transcription of the HIV genome";"HATs acetylate histones";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape"
Mdes009035-RA	6	MetaCyc: PWY-7920;KEGG: 00513+2.4.1.143;Reactome: R-HSA-4793952;MetaCyc: PWY-7426;Reactome: R-HSA-975578;KEGG: 00510+2.4.1.143	"Complex N-linked glycan biosynthesis (plants)";"Various types of N-glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (vertebrates)";"Reactions specific to the complex N-glycan synthesis pathway";"N-Glycan biosynthesis"
Mdes001329-RA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
Mdes016473-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes005626-RB	3	Reactome: R-HSA-5617472;Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Mdes004152-RB	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
Mdes006734-RB	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes008350-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
Mdes018709-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes002641-RA	2	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
Mdes010182-RA	16	Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-176409;Reactome: R-HSA-174084;Reactome: R-HSA-141430;Reactome: R-HSA-176408;Reactome: R-HSA-174154;Reactome: R-HSA-174048;Reactome: R-HSA-2559582;Reactome: R-HSA-176412;Reactome: R-HSA-8853884;Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-2467813	"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Autodegradation of Cdh1 by Cdh1:APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdc20 mediated degradation of Cyclin B";"Senescence-Associated Secretory Phenotype (SASP)";"Phosphorylation of the APC/C";"Transcriptional Regulation by VENTX";"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids"
Mdes011707-RA	6	Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-427359;Reactome: R-HSA-73762	"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"SIRT1 negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation"
Mdes003442-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes001352-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
Mdes008094-RB	3	Reactome: R-HSA-5696395;Reactome: R-HSA-5696394;Reactome: R-HSA-3108214	"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER";"SUMOylation of DNA damage response and repair proteins"
Mdes003792-RF	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
Mdes019142-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes007192-RB	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes008424-RA	7	KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1	"Relaxin signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway"
Mdes008558-RD	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes001851-RB	4	Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947	"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
Mdes000312-RH	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
Mdes001515-RA	5	Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14	"Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism"
Mdes004709-RA	5	Reactome: R-HSA-5628897;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-611105;Reactome: R-HSA-5419276	"TP53 Regulates Metabolic Genes";"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Respiratory electron transport";"Mitochondrial translation termination"
Mdes002413-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes017542-RA	1	KEGG: 00400+5.3.1.24	"Phenylalanine, tyrosine and tryptophan biosynthesis"
Mdes012014-RA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Mdes011124-RB	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes010218-RB	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
Mdes000687-RA	39	Reactome: R-HSA-170822;Reactome: R-HSA-983170;Reactome: R-HSA-4615885;Reactome: R-HSA-204005;Reactome: R-HSA-3371453;Reactome: R-HSA-9639288;Reactome: R-HSA-168333;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-165054;Reactome: R-HSA-2467813;Reactome: R-HSA-2132295;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-3232142;Reactome: R-HSA-141444;Reactome: R-HSA-5619107;Reactome: R-HSA-9648025;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-159230;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-5663220;Reactome: R-HSA-6799198;Reactome: R-HSA-159231;Reactome: R-HSA-611105;Reactome: R-HSA-4570464;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-2500257;Reactome: R-HSA-180910;Reactome: R-HSA-4085377;Reactome: R-HSA-180746	"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"SUMOylation of DNA replication proteins";"COPII-mediated vesicle transport";"Regulation of HSF1-mediated heat shock response";"Amino acids regulate mTORC1";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Rev-mediated nuclear export of HIV RNA";"Separation of Sister Chromatids";"MHC class II antigen presentation";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"HCMV Late Events";"SUMOylation of ubiquitinylation proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"EML4 and NUDC in mitotic spindle formation";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Mitotic Prometaphase";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"RHO GTPases Activate Formins";"Complex I biogenesis";"Transport of Mature mRNA Derived from an Intronless Transcript";"Respiratory electron transport";"SUMOylation of RNA binding proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"Resolution of Sister Chromatid Cohesion";"Vpr-mediated nuclear import of PICs";"SUMOylation of SUMOylation proteins";"Nuclear import of Rev protein"
Mdes001886-RB	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
Mdes002069-RA	3	Reactome: R-HSA-450513;Reactome: R-HSA-430039;Reactome: R-HSA-450385	"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes002308-RA	1	KEGG: 00520+3.2.1.132	"Amino sugar and nucleotide sugar metabolism"
Mdes004494-RA	56	Reactome: R-HSA-5607764;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-187577;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5668541;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5358346	"CLEC7A (Dectin-1) signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"SCF(Skp2)-mediated degradation of p27/p21";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"TNFR2 non-canonical NF-kB pathway";"Neddylation";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Hedgehog ligand biogenesis"
Mdes003322-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Mdes009946-RB	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes006536-RA	4	Reactome: R-HSA-6807062;Reactome: R-HSA-6807047;KEGG: 00100+1.3.1.72;MetaCyc: PWY-8026	"Cholesterol biosynthesis via lathosterol";"Cholesterol biosynthesis via desmosterol";"Steroid biosynthesis";"Sterol biosynthesis (methylotrophs)"
Mdes008310-RA	4	Reactome: R-HSA-1660499;Reactome: R-HSA-8950505;Reactome: R-HSA-1237112;Reactome: R-HSA-1632852	"Synthesis of PIPs at the plasma membrane";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Methionine salvage pathway";"Macroautophagy"
Mdes003666-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Mdes012349-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes015156-RA	3	Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355	"Nitric oxide stimulates guanylate cyclase";"Purine metabolism";"Smooth Muscle Contraction"
Mdes016748-RA	3	MetaCyc: PWY-7892;MetaCyc: PWY-7887;Reactome: R-HSA-6787450	"Trna-uridine 2-thiolation and selenation (bacteria)";"Protein SAMPylation and SAMP-mediated thiolation";"tRNA modification in the mitochondrion"
Mdes014335-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Mdes007174-RA	5	Reactome: R-HSA-917729;Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Budding and maturation of HIV virion"
Mdes016209-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes014561-RA	7	KEGG: 00230+6.3.3.1;MetaCyc: PWY-6277;MetaCyc: PWY-6121;MetaCyc: PWY-6122;Reactome: R-HSA-73817;KEGG: 00230+6.3.4.13;Reactome: R-HSA-196780	"Purine metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"5-aminoimidazole ribonucleotide biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Biotin transport and metabolism"
Mdes006218-RA	3	Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154	"Smooth Muscle Contraction";"Purine metabolism";"Nitric oxide stimulates guanylate cyclase"
Mdes016167-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Mdes010467-RA	5	Reactome: R-HSA-5689880;Reactome: R-HSA-4641257;Reactome: R-HSA-8948751;Reactome: R-HSA-5545619;Reactome: R-HSA-201681	"Ub-specific processing proteases";"Degradation of AXIN";"Regulation of PTEN stability and activity";"XAV939 inhibits tankyrase, stabilizing AXIN";"TCF dependent signaling in response to WNT"
Mdes010463-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes009751-RA	23	Reactome: R-HSA-418555;Reactome: R-HSA-392851;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-392451;Reactome: R-HSA-416476;Reactome: R-HSA-400042;Reactome: R-HSA-392170;Reactome: R-HSA-420092;Reactome: R-HSA-8964315;Reactome: R-HSA-6814122;Reactome: R-HSA-416482;Reactome: R-HSA-418597;Reactome: R-HSA-9009391;Reactome: R-HSA-8964616;Reactome: R-HSA-4086398;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-381676;Reactome: R-HSA-202040;Reactome: R-HSA-500657;Reactome: R-HSA-418217;Reactome: R-HSA-456926	"G alpha (s) signalling events";"Prostacyclin signalling through prostacyclin receptor";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through PI3Kgamma";"G alpha (q) signalling events";"Adrenaline,noradrenaline inhibits insulin secretion";"ADP signalling through P2Y purinoceptor 12";"Glucagon-type ligand receptors";"G beta:gamma signalling through BTK";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (12/13) signalling events";"G alpha (z) signalling events";"Extra-nuclear estrogen signaling";"G beta:gamma signalling through CDC42";"Ca2+ pathway";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G-protein activation";"Presynaptic function of Kainate receptors";"G beta:gamma signalling through PLC beta";"Thrombin signalling through proteinase activated receptors (PARs)"
Mdes008663-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902	"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation"
Mdes005720-RA	22	MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-7725;MetaCyc: PWY-7602;MetaCyc: PWY-7727;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-7606;MetaCyc: PWY-7592;MetaCyc: PWY-7728;KEGG: 00062+4.2.1.134;MetaCyc: PWY-6598;MetaCyc: PWY-7726;MetaCyc: PWY-7049;MetaCyc: PWY-6433;MetaCyc: PWY-6958;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7053;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-5353	"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Fatty acid elongation";"Sciadonate biosynthesis";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)"
Mdes001274-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes009732-RA	3	MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
Mdes004887-RA	9	Reactome: R-HSA-68962;Reactome: R-HSA-69205;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-69017;Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-1362277;Reactome: R-HSA-68689	"Activation of the pre-replicative complex";"G1/S-Specific Transcription";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"CDK-mediated phosphorylation and removal of Cdc6";"CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"Transcription of E2F targets under negative control by DREAM complex";"CDC6 association with the ORC:origin complex"
Mdes012750-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Mdes008655-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes004009-RA	3	KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783;MetaCyc: PWY-3961	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II"
Mdes004939-RA	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
Mdes009647-RB	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes016111-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes005832-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes006878-RB	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Mdes018068-RA	15	Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8936459;Reactome: R-HSA-8943723;Reactome: R-HSA-8853884;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-4086398;Reactome: R-HSA-2559580;Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-9029569;Reactome: R-HSA-2559585	"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by VENTX";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Ca2+ pathway";"Oxidative Stress Induced Senescence";"Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oncogene Induced Senescence"
Mdes006917-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes007857-RA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
Mdes002003-RA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
Mdes015149-RA	4	MetaCyc: PWY-7268;KEGG: 00480+1.1.1.49;MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49	"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism";"Entner-Doudoroff pathway I";"Pentose phosphate pathway"
Mdes003670-RC	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
Mdes000708-RA	2	Reactome: R-HSA-1663150;Reactome: R-HSA-1660662	"The activation of arylsulfatases";"Glycosphingolipid metabolism"
Mdes005690-RA	4	KEGG: 00983+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48;Reactome: R-HSA-73614	"Drug metabolism - other enzymes";"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism";"Pyrimidine salvage"
Mdes005396-RA	3	KEGG: 00460+3.5.1.1;KEGG: 00250+3.5.1.1;Reactome: R-HSA-8963693	"Cyanoamino acid metabolism";"Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism"
Mdes011708-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes001608-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes001072-RA	1	Reactome: R-HSA-71384	"Ethanol oxidation"
Mdes006540-RA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
Mdes009225-RA	42	Reactome: R-HSA-8936459;Reactome: R-HSA-5578749;Reactome: R-HSA-73728;Reactome: R-HSA-5334118;Reactome: R-HSA-5693607;Reactome: R-HSA-8939236;Reactome: R-HSA-5693571;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-3214858;Reactome: R-HSA-2559586;Reactome: R-HSA-73772;Reactome: R-HSA-3214815;Reactome: R-HSA-9610379;Reactome: R-HSA-5625886;Reactome: R-HSA-171306;Reactome: R-HSA-9616222;Reactome: R-HSA-3214847;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-427389;Reactome: R-HSA-4551638;Reactome: R-HSA-977225;Reactome: R-HSA-427413;Reactome: R-HSA-427359;Reactome: R-HSA-1912408;Reactome: R-HSA-9018519;Reactome: R-HSA-606279;Reactome: R-HSA-1221632;Reactome: R-HSA-212300;Reactome: R-HSA-5250924;Reactome: R-HSA-912446;Reactome: R-HSA-2559582;Reactome: R-HSA-9609690;Reactome: R-HSA-2299718;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-110330;Reactome: R-HSA-5693565;Reactome: R-HSA-110328;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional regulation by small RNAs";"RNA Polymerase I Promoter Opening";"DNA methylation";"Processing of DNA double-strand break ends";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Nonhomologous End-Joining (NHEJ)";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"RMTs methylate histone arginines";"DNA Damage/Telomere Stress Induced Senescence";"RNA Polymerase I Promoter Escape";"HDACs deacetylate histones";"HCMV Late Events";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Packaging Of Telomere Ends";"Transcriptional regulation of granulopoiesis";"HATs acetylate histones";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"SUMOylation of chromatin organization proteins";"Amyloid fiber formation";"NoRC negatively regulates rRNA expression";"SIRT1 negatively regulates rRNA expression";"Pre-NOTCH Transcription and Translation";"Estrogen-dependent gene expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"Meiotic synapsis";"PRC2 methylates histones and DNA";"B-WICH complex positively regulates rRNA expression";"Meiotic recombination";"Senescence-Associated Secretory Phenotype (SASP)";"HCMV Early Events";"Condensation of Prophase Chromosomes";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
Mdes012758-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Mdes005678-RB	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Mdes015774-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes006636-RA	12	Reactome: R-HSA-6804756;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-380972;Reactome: R-HSA-9619483;KEGG: 05170+2.7.11.1;Reactome: R-HSA-1632852;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Regulation of TP53 Activity through Phosphorylation";"Human papillomavirus infection";"mTOR signaling pathway";"Energy dependent regulation of mTOR by LKB1-AMPK";"Activation of AMPK downstream of NMDARs";"Human immunodeficiency virus 1 infection";"Macroautophagy";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"TP53 Regulates Metabolic Genes";"Thermogenesis";"Relaxin signaling pathway"
Mdes014508-RA	3	KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361;MetaCyc: PWY-7174	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II"
Mdes000095-RA	7	Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2660826	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant"
Mdes010105-RA	2	Reactome: R-HSA-975956;Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes003300-RB	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes011409-RA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-202427;Reactome: R-HSA-6807004	"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity"
Mdes015288-RA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
Mdes004752-RC	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes014743-RA	1	Reactome: R-HSA-111957	"Cam-PDE 1 activation"
Mdes010540-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes009476-RB	3	Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-381340	"PPARA activates gene expression";"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation"
Mdes018018-RA	4	KEGG: 00332+2.7.2.11;MetaCyc: PWY-6922;Reactome: R-HSA-8964539;KEGG: 00330+2.7.2.11	"Carbapenem biosynthesis";"L-Ndelta-acetylornithine biosynthesis";"Glutamate and glutamine metabolism";"Arginine and proline metabolism"
Mdes007413-RA	2	Reactome: R-HSA-110320;Reactome: R-HSA-5689880	"Translesion Synthesis by POLH";"Ub-specific processing proteases"
Mdes010451-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes014142-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Mdes014361-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes006213-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes018271-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Mdes002027-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Mdes012126-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes014103-RA	5	Reactome: R-HSA-1362409;Reactome: R-HSA-5579026;Reactome: R-HSA-2395516;Reactome: R-HSA-196108;Reactome: R-HSA-211976	"Mitochondrial iron-sulfur cluster biogenesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Electron transport from NADPH to Ferredoxin";"Pregnenolone biosynthesis";"Endogenous sterols"
Mdes000025-RB	16	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes013098-RB	4	KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219	"Purine metabolism";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis"
Mdes018726-RA	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
Mdes001730-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Mdes004257-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes000330-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes009490-RA	5	MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085;MetaCyc: PWY-6902;MetaCyc: PWY-6855	"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate";"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)"
Mdes019639-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes008702-RA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
Mdes009144-RA	7	Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912	"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane"
Mdes004203-RA	3	Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events"
Mdes005590-RB	3	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.20;Reactome: R-HSA-5658442	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Regulation of RAS by GAPs"
Mdes011286-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes000641-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes008409-RA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
Mdes007645-RA	9	Reactome: R-HSA-70171;MetaCyc: PWY-8004;MetaCyc: PWY-1042;KEGG: 00710+1.2.1.12;MetaCyc: PWY-5484;KEGG: 00010+1.2.1.12;Reactome: R-HSA-70263;MetaCyc: PWY-7003;MetaCyc: PWY-6901	"Glycolysis";"Entner-Doudoroff pathway I";"Glycolysis IV (plant cytosol)";"Carbon fixation in photosynthetic organisms";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Glycerol degradation to butanol";"Superpathway of glucose and xylose degradation"
Mdes014446-RA	9	Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607	"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends"
Mdes004557-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
Mdes004986-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes005532-RC	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Mdes010719-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Mdes011105-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes009043-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Mdes002213-RB	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes003680-RA	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
Mdes009798-RA	7	Reactome: R-HSA-1538133;Reactome: R-HSA-156711;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-69656	"G0 and Early G1";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry"
Mdes000434-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Mdes004201-RA	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
Mdes020103-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes015911-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes011235-RA	3	Reactome: R-HSA-204005;Reactome: R-HSA-162658;Reactome: R-HSA-6807878	"COPII-mediated vesicle transport";"Golgi Cisternae Pericentriolar Stack Reorganization";"COPI-mediated anterograde transport"
Mdes001406-RA	4	MetaCyc: PWY-6855;MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14	"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism"
Mdes001875-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Mdes009093-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes000664-RA	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
Mdes005488-RA	5	KEGG: 00620+4.1.1.32;Reactome: R-HSA-70263;KEGG: 00010+4.1.1.32;KEGG: 00020+4.1.1.32;MetaCyc: PWY-7383	"Pyruvate metabolism";"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, cytosol)"
Mdes007279-RC	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway"
Mdes008319-RD	3	Reactome: R-HSA-1358803;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes016462-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes012676-RA	33	Reactome: R-HSA-4085377;Reactome: R-HSA-180746;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-159231;Reactome: R-HSA-5663220;Reactome: R-HSA-4551638;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-3108214;Reactome: R-HSA-159227;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-141444;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-2467813;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-170822	"SUMOylation of SUMOylation proteins";"Nuclear import of Rev protein";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Mature mRNA Derived from an Intronless Transcript";"RHO GTPases Activate Formins";"SUMOylation of chromatin organization proteins";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP independent Mature mRNA";"Mitotic Prometaphase";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"HCMV Late Events";"Separation of Sister Chromatids";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein"
Mdes017819-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes007414-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes016803-RA	5	Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;Reactome: R-HSA-9648895;Reactome: R-HSA-380994;KEGG: 00250+6.3.5.4	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"Response of EIF2AK1 (HRI) to heme deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress";"Alanine, aspartate and glutamate metabolism"
Mdes012525-RA	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
Mdes010394-RA	20	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-1257604;Reactome: R-HSA-389357;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-166208;Reactome: R-HSA-165159;Reactome: R-HSA-3371571;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-5218920;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;Reactome: R-HSA-6804757;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTORC1-mediated signalling";"mTOR signalling";"HSF1-dependent transactivation";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"Relaxin signaling pathway";"TP53 Regulates Metabolic Genes";"Macroautophagy";"VEGFR2 mediated vascular permeability";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of TP53 Degradation";"mTOR signaling pathway";"Human papillomavirus infection"
Mdes012594-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes000219-RA	17	Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6790901;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706	"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"rRNA modification in the nucleus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Mdes005358-RD	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Mdes014855-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Mdes000355-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes005734-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes006483-RB	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
Mdes006853-RA	6	Reactome: R-HSA-6803211;Reactome: R-HSA-139915;Reactome: R-HSA-6803207;Reactome: R-HSA-6803204;Reactome: R-HSA-6804759;Reactome: R-HSA-6803205	"TP53 Regulates Transcription of Death Receptors and Ligands";"Activation of PUMA and translocation to mitochondria";"TP53 Regulates Transcription of Caspase Activators and Caspases";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Regulation of TP53 Activity through Association with Co-factors";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"
Mdes006945-RB	13	Reactome: R-HSA-2132295;Reactome: R-HSA-182218;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-8856828;Reactome: R-HSA-437239;Reactome: R-HSA-8866427;Reactome: R-HSA-8856825;Reactome: R-HSA-5140745;Reactome: R-HSA-167590;Reactome: R-HSA-8964038;Reactome: R-HSA-5099900;Reactome: R-HSA-177504	"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"Clathrin-mediated endocytosis";"Recycling pathway of L1";"VLDLR internalisation and degradation";"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Nef Mediated CD4 Down-regulation";"LDL clearance";"WNT5A-dependent internalization of FZD4";"Retrograde neurotrophin signalling"
Mdes000035-RA	22	Reactome: R-HSA-5339716;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-141444;Reactome: R-HSA-5467340;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-4641262;Reactome: R-HSA-389513;Reactome: R-HSA-5358749;Reactome: R-HSA-5663220;Reactome: R-HSA-5675221;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-5358751;Reactome: R-HSA-5673000;Reactome: R-HSA-5467348;Reactome: R-HSA-5358747;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-6811558;Reactome: R-HSA-432142	"Misspliced GSK3beta mutants stabilize beta-catenin";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"AXIN missense mutants destabilize the destruction complex";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"CTLA4 inhibitory signaling";"S37 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"Negative regulation of MAPK pathway";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"S45 mutants of beta-catenin aren't phosphorylated";"RAF activation";"Truncations of AMER1 destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Platelet sensitization by LDL"
Mdes002500-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes001749-RB	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
Mdes010771-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes010314-RA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Mdes003813-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes012377-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
Mdes005602-RA	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes012869-RC	5	Reactome: R-HSA-196807;MetaCyc: PWY-7221;Reactome: R-HSA-73621;Reactome: R-HSA-74259;KEGG: 00230+2.7.4.8	"Nicotinate metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine catabolism";"Purine catabolism";"Purine metabolism"
Mdes009675-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes007861-RB	6	MetaCyc: PWY-6124;MetaCyc: PWY-6123;MetaCyc: PWY-7234;KEGG: 00230+4.1.1.21;Reactome: R-HSA-73817;KEGG: 00230+6.3.2.6	"Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism"
Mdes010689-RB	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes004984-RA	1	Reactome: R-HSA-5693565	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
Mdes002182-RB	1	Reactome: R-HSA-5617833	"Cilium Assembly"
Mdes010947-RA	6	Reactome: R-HSA-1660499;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1660516;KEGG: 00562+3.1.3.66;KEGG: 04070+3.1.3.66	"Synthesis of PIPs at the plasma membrane";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the early endosome membrane";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system"
Mdes014197-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Mdes003728-RA	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.15	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes009822-RB	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes009374-RA	7	KEGG: 00521+3.1.3.25;KEGG: 04070+3.1.3.25;Reactome: R-HSA-1855183;MetaCyc: PWY-4702;KEGG: 00562+3.1.3.25;MetaCyc: PWY-6363;MetaCyc: PWY-2301	"Streptomycin biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"Phytate degradation I";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Myo-inositol biosynthesis"
Mdes002052-RA	12	MetaCyc: PWY-5108;MetaCyc: PWY-6672;KEGG: 00010+6.2.1.1;KEGG: 00620+6.2.1.1;KEGG: 00640+6.2.1.1;KEGG: 00720+6.2.1.1;KEGG: 00680+6.2.1.1;MetaCyc: PWY-7857;MetaCyc: PWY-5133;MetaCyc: PWY-7118;KEGG: 00630+6.2.1.1;MetaCyc: PWY-5132	"L-isoleucine biosynthesis V";"Cis-genanyl-coa degradation";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Methane metabolism";"Adlupulone and adhumulone biosynthesis";"Colupulone and cohumulone biosynthesis";"Chitin degradation to ethanol";"Glyoxylate and dicarboxylate metabolism";"Lupulone and humulone biosynthesis"
Mdes010152-RA	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
Mdes020083-RA	3	Reactome: R-HSA-191859;Reactome: R-HSA-3214858;Reactome: R-HSA-6804760	"snRNP Assembly";"RMTs methylate histone arginines";"Regulation of TP53 Activity through Methylation"
Mdes006187-RA	18	Reactome: R-HSA-1482922;MetaCyc: PWY-7417;MetaCyc: PWY-8053;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925;MetaCyc: PWY-7416;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;KEGG: 00591+3.1.1.4;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482839;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-6803;Reactome: R-HSA-1482801	"Acyl chain remodelling of PI";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Linoleic acid metabolism";"Arachidonic acid metabolism";"Acyl chain remodelling of PE";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PS"
Mdes007649-RB	9	Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-73776	"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape"
Mdes008908-RA	12	Reactome: R-HSA-163560;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;KEGG: 04658+3.1.3.16;Reactome: R-HSA-400253;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-2173788	"Triglyceride catabolism";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Th1 and Th2 cell differentiation";"Circadian Clock";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Downregulation of TGF-beta receptor signaling"
Mdes010667-RC	5	MetaCyc: PWY-6277;Reactome: R-HSA-73817;MetaCyc: PWY-6122;KEGG: 00230+6.3.5.3;MetaCyc: PWY-6121	"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I"
Mdes011386-RB	17	Reactome: R-HSA-139915;Reactome: R-HSA-2173796;Reactome: R-HSA-69205;Reactome: R-HSA-1362300;Reactome: R-HSA-1912408;Reactome: R-HSA-1538133;Reactome: R-HSA-2559585;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-111448;Reactome: R-HSA-8953750;Reactome: R-HSA-69231;Reactome: R-HSA-1362277;Reactome: R-HSA-9616222;Reactome: R-HSA-113501;Reactome: R-HSA-2559580;Reactome: R-HSA-6804114	"Activation of PUMA and translocation to mitochondria";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Pre-NOTCH Transcription and Translation";"G0 and Early G1";"Oncogene Induced Senescence";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"Activation of NOXA and translocation to mitochondria";"Transcriptional Regulation by E2F6";"Cyclin D associated events in G1";"Transcription of E2F targets under negative control by DREAM complex";"Transcriptional regulation of granulopoiesis";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Oxidative Stress Induced Senescence";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"
Mdes011527-RA	6	Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-69473;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-5693616	"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange"
Mdes007111-RA	4	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-77595;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway"
Mdes009393-RA	4	Reactome: R-HSA-69202;Reactome: R-HSA-8953750;Reactome: R-HSA-1362277;Reactome: R-HSA-69656	"Cyclin E associated events during G1/S transition";"Transcriptional Regulation by E2F6";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry"
Mdes004504-RC	2	Reactome: R-HSA-2299718;Reactome: R-HSA-2514853	"Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes"
Mdes009962-RA	2	Reactome: R-HSA-500753;Reactome: R-HSA-73621	"Pyrimidine biosynthesis";"Pyrimidine catabolism"
Mdes000647-RA	3	Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
Mdes005903-RA	1	Reactome: R-HSA-6804756	"Regulation of TP53 Activity through Phosphorylation"
Mdes008720-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes000235-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes011794-RA	3	MetaCyc: PWY-4361;KEGG: 00270+1.13.11.54;Reactome: R-HSA-1237112	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism";"Methionine salvage pathway"
Mdes009680-RD	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
Mdes000802-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Mdes005724-RA	5	Reactome: R-HSA-432722;Reactome: R-HSA-72764;Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-156581	"Golgi Associated Vesicle Biogenesis";"Eukaryotic Translation Termination";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Methylation"
Mdes010674-RA	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
Mdes015232-RA	10	Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-3108214;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938	"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"SUMOylation of DNA damage response and repair proteins";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)"
Mdes017891-RA	1	Reactome: R-HSA-373752	"Netrin-1 signaling"
Mdes019833-RA	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Mdes001627-RA	8	Reactome: R-HSA-77387;KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;MetaCyc: PWY-7980;Reactome: R-HSA-917977	"Insulin receptor recycling";"Photosynthesis";"Oxidative phosphorylation";"Ion channel transport";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"ATP biosynthesis";"Transferrin endocytosis and recycling"
Mdes007523-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes007733-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes000312-RD	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Mdes001666-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes001142-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes009541-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes005916-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Mdes009773-RA	5	KEGG: 00500+2.4.1.18;MetaCyc: PWY-7900;Reactome: R-HSA-189085;MetaCyc: PWY-5067;MetaCyc: PWY-622	"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Digestion of dietary carbohydrate";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch biosynthesis"
Mdes006148-RC	2	Reactome: R-HSA-5218920;Reactome: R-HSA-418990	"VEGFR2 mediated vascular permeability";"Adherens junctions interactions"
Mdes007644-RB	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
Mdes001508-RA	56	Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5668541;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-187577;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815	"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Neddylation";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"TNFR2 non-canonical NF-kB pathway";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"SCF(Skp2)-mediated degradation of p27/p21";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D"
Mdes005962-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Mdes013846-RA	4	Reactome: R-HSA-419037;Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
Mdes006367-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes008484-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes010157-RA	5	Reactome: R-HSA-1834949;Reactome: R-HSA-3270619;Reactome: R-HSA-5693571;Reactome: R-HSA-164843;Reactome: R-HSA-6798695	"Cytosolic sensors of pathogen-associated DNA";"IRF3-mediated induction of type I IFN";"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation";"Neutrophil degranulation"
Mdes017609-RA	9	MetaCyc: PWY-6147;MetaCyc: PWY-6983;Reactome: R-HSA-1474151;MetaCyc: PWY-5664;MetaCyc: PWY-6703;MetaCyc: PWY-7852;MetaCyc: PWY-5663;KEGG: 00790+3.5.4.16;MetaCyc: PWY-7442	"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Threo-tetrahydrobiopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis II";"Preq0 biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Erythro-tetrahydrobiopterin biosynthesis I";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis"
Mdes011623-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes015496-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes013465-RA	16	Reactome: R-HSA-167200;Reactome: R-HSA-167152;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-674695;Reactome: R-HSA-180585;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167287	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"RNA Polymerase II Pre-transcription Events";"Vif-mediated degradation of APOBEC3G";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery"
Mdes011477-RA	15	Reactome: R-HSA-2467813;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-141430;Reactome: R-HSA-179409;Reactome: R-HSA-174084;Reactome: R-HSA-176409;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-8853884;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-69017	"Separation of Sister Chromatids";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC-Cdc20 mediated degradation of Nek2A";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Transcriptional Regulation by VENTX";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"CDK-mediated phosphorylation and removal of Cdc6"
Mdes001528-RA	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
Mdes005256-RA	4	MetaCyc: PWY-6129;Reactome: R-HSA-4755609;KEGG: 00900+2.5.1.87;Reactome: R-HSA-446199	"Dolichol and dolichyl phosphate biosynthesis";"Defective DHDDS causes retinitis pigmentosa 59";"Terpenoid backbone biosynthesis";"Synthesis of Dolichyl-phosphate"
Mdes009077-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Mdes010894-RB	7	MetaCyc: PWY-6737;Reactome: R-HSA-6798695;KEGG: 00500+2.4.1.25;MetaCyc: PWY-6724;Reactome: R-HSA-70221;MetaCyc: PWY-7238;MetaCyc: PWY-5941	"Starch degradation V";"Neutrophil degranulation";"Starch and sucrose metabolism";"Starch degradation II";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II";"Glycogen degradation II"
Mdes000110-RA	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
Mdes006160-RA	2	Reactome: R-HSA-75105;KEGG: 00062+3.1.2.22	"Fatty acyl-CoA biosynthesis";"Fatty acid elongation"
Mdes004640-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes000806-RA	2	Reactome: R-HSA-204005;Reactome: R-HSA-5694530	"COPII-mediated vesicle transport";"Cargo concentration in the ER"
Mdes012657-RA	2	Reactome: R-HSA-202733;Reactome: R-HSA-416993	"Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors"
Mdes005984-RA	34	Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-168333;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-9639288;Reactome: R-HSA-3371453;Reactome: R-HSA-2467813;Reactome: R-HSA-165054;Reactome: R-HSA-3232142;Reactome: R-HSA-141444;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-159227;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-5663220;Reactome: R-HSA-168276;Reactome: R-HSA-3108214;Reactome: R-HSA-159230;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-2500257;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-4085377;Reactome: R-HSA-180746;Reactome: R-HSA-180910	"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"NEP/NS2 Interacts with the Cellular Export Machinery";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Amino acids regulate mTORC1";"Regulation of HSF1-mediated heat shock response";"Separation of Sister Chromatids";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of ubiquitinylation proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"Transport of the SLBP independent Mature mRNA";"Mitotic Prometaphase";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"RHO GTPases Activate Formins";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP Dependant Mature mRNA";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Resolution of Sister Chromatid Cohesion";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of SUMOylation proteins";"Nuclear import of Rev protein";"Vpr-mediated nuclear import of PICs"
Mdes016932-RB	7	KEGG: 00051+3.1.3.11;KEGG: 00030+3.1.3.11;MetaCyc: PWY-5484;Reactome: R-HSA-70263;KEGG: 00010+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11	"Fructose and mannose metabolism";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)";"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Methane metabolism"
Mdes002024-RB	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes000142-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Mdes001307-RA	13	KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-6798695;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;KEGG: 00600+3.2.1.23;Reactome: R-HSA-4341670;KEGG: 00531+3.2.1.23;Reactome: R-HSA-4085001;Reactome: R-HSA-2024096;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2206308	"Galactose metabolism";"Other glycan degradation";"Neutrophil degranulation";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Sphingolipid metabolism";"Defective NEU1 causes sialidosis";"Glycosaminoglycan degradation";"Sialic acid metabolism";"HS-GAG degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"MPS IV - Morquio syndrome B"
Mdes002503-RB	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
Mdes019656-RA	3	MetaCyc: PWY-1269;Reactome: R-HSA-4085001;KEGG: 00540+2.7.7.38	"CMP-3-deoxy-D-manno-octulosonate biosynthesis";"Sialic acid metabolism";"Lipopolysaccharide biosynthesis"
Mdes016603-RA	10	MetaCyc: PWY-5849;MetaCyc: PWY-5844;KEGG: 00130+2.1.1.163;MetaCyc: PWY-5895;MetaCyc: PWY-5892;MetaCyc: PWY-7996;MetaCyc: PWY-5890;Reactome: R-HSA-2142789;MetaCyc: PWY-5839;MetaCyc: PWY-5891	"Menaquinol-6 biosynthesis";"Menaquinol-9 biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Menaquinol-13 biosynthesis";"Menaquinol-12 biosynthesis";"Menaquinol-4 biosynthesis I";"Menaquinol-10 biosynthesis";"Ubiquinol biosynthesis";"Menaquinol-7 biosynthesis";"Menaquinol-11 biosynthesis"
Mdes010025-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes007279-RA	7	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection"
Mdes003664-RB	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
Mdes010057-RA	5	KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7979;MetaCyc: PWY-7922	"Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)"
Mdes004826-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes018690-RA	1	KEGG: 00340+3.6.1.31	"Histidine metabolism"
Mdes007383-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Mdes004014-RA	8	Reactome: R-HSA-4551638;Reactome: R-HSA-8953750;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-3214841;Reactome: R-HSA-8943724;Reactome: R-HSA-5617472;Reactome: R-HSA-9609690	"SUMOylation of chromatin organization proteins";"Transcriptional Regulation by E2F6";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"PKMTs methylate histone lysines";"Regulation of PTEN gene transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HCMV Early Events"
Mdes018373-RA	1	Reactome: R-HSA-77108	"Utilization of Ketone Bodies"
Mdes001826-RA	4	KEGG: 00270+5.3.1.23;Reactome: R-HSA-1237112;MetaCyc: PWY-7174;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
Mdes005636-RA	4	Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes019671-RA	4	Reactome: R-HSA-73817;KEGG: 00230+6.3.4.4;MetaCyc: PWY-7219;KEGG: 00250+6.3.4.4	"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Alanine, aspartate and glutamate metabolism"
Mdes004026-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes019730-RA	3	Reactome: R-HSA-70263;Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Gluconeogenesis";"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
Mdes007247-RC	7	Reactome: R-HSA-1660516;MetaCyc: PWY-6351;Reactome: R-HSA-1660499;Reactome: R-HSA-1660514;KEGG: 00562+2.7.1.67;KEGG: 04070+2.7.1.67;MetaCyc: PWY-6352	"Synthesis of PIPs at the early endosome membrane";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the Golgi membrane";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"3-phosphoinositide biosynthesis"
Mdes006273-RA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
Mdes011714-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-264876;Reactome: R-HSA-5620916	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing";"VxPx cargo-targeting to cilium"
Mdes001459-RA	3	Reactome: R-HSA-430039;Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Mdes015024-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes012266-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes010546-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Mdes015149-RB	4	MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49;MetaCyc: PWY-7268;KEGG: 00480+1.1.1.49	"Entner-Doudoroff pathway I";"Pentose phosphate pathway";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism"
Mdes008524-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes011948-RA	40	Reactome: R-HSA-674695;Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-6782210;Reactome: R-HSA-6803529;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-72165;Reactome: R-HSA-73779;Reactome: R-HSA-5601884;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-6796648;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-5578749;Reactome: R-HSA-112382;Reactome: R-HSA-203927;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-5617472;Reactome: R-HSA-168325;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-72203;Reactome: R-HSA-77075;Reactome: R-HSA-167242;Reactome: R-HSA-72163;Reactome: R-HSA-9018519;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-8851708;Reactome: R-HSA-167162;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-167238;Reactome: R-HSA-167243	"RNA Polymerase II Pre-transcription Events";"Dual incision in TC-NER";"HIV Transcription Initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"FGFR2 alternative splicing";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"PIWI-interacting RNA (piRNA) biogenesis";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Transcriptional regulation by small RNAs";"Formation of RNA Pol II elongation complex";"MicroRNA (miRNA) biogenesis";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Viral Messenger RNA Synthesis";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Pol II CTD phosphorylation and interaction with CE";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Major Pathway";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II HIV Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery"
Mdes000199-RA	16	Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-2408557	"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis"
Mdes012825-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes011316-RA	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
Mdes007428-RA	3	Reactome: R-HSA-6784531;Reactome: R-HSA-6785470;Reactome: R-HSA-8868766	"tRNA processing in the nucleus";"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion"
Mdes019686-RA	2	KEGG: 00630+4.1.3.1;MetaCyc: PWY-6969	"Glyoxylate and dicarboxylate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)"
Mdes003060-RA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Mdes016901-RA	14	MetaCyc: PWY-2201;MetaCyc: PWY-1622;MetaCyc: PWY-2161;MetaCyc: PWY-3661;Reactome: R-HSA-196757;MetaCyc: PWY-181;MetaCyc: PWY-3841;KEGG: 00680+2.1.2.1;KEGG: 00670+2.1.2.1;KEGG: 00460+2.1.2.1;MetaCyc: PWY-5497;KEGG: 00630+2.1.2.1;KEGG: 00260+2.1.2.1;MetaCyc: PWY-3661-1	"Folate transformations I";"Formaldehyde assimilation I (serine pathway)";"Folate polyglutamylation";"Glycine betaine degradation I";"Metabolism of folate and pterines";"Photorespiration ";"Folate transformations II (plants)";"Methane metabolism";"One carbon pool by folate";"Cyanoamino acid metabolism";"Purine nucleobases degradation II (anaerobic)";"Glyoxylate and dicarboxylate metabolism";"Glycine, serine and threonine metabolism";"Glycine betaine degradation II (mammalian)"
Mdes009049-RA	5	Reactome: R-HSA-73856;Reactome: R-HSA-159231;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-77595	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs"
Mdes012967-RA	4	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893;Reactome: R-HSA-419037;Reactome: R-HSA-112308	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase";"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening"
Mdes007004-RA	7	Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380270	"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes"
Mdes000657-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes016114-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes001444-RA	1	Reactome: R-HSA-2467813	"Separation of Sister Chromatids"
Mdes000588-RB	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes015672-RA	40	KEGG: 00071+4.2.1.17+1.1.1.35;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-7726;MetaCyc: PWY-7094;MetaCyc: PWY-7778;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;KEGG: 00410+4.2.1.17;MetaCyc: PWY-5789;KEGG: 00623+1.1.1.35;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6946;MetaCyc: PWY-6945;MetaCyc: PWY-6883;MetaCyc: PWY-5109;MetaCyc: PWY-7401;MetaCyc: PWY-6583;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6944;MetaCyc: PWY-5138;MetaCyc: PWY-7606;MetaCyc: PWY-7656;MetaCyc: PWY-7779;KEGG: 00640+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-5136;KEGG: 00592+4.2.1.17;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-6863;MetaCyc: PWY-7216;KEGG: 00360+4.2.1.17;MetaCyc: PWY-7007;MetaCyc: PWY-7654;MetaCyc: PWY-5177	"Fatty acid degradation";"Benzoate degradation";"Benzoyl-coa degradation I (aerobic)";"Valine, leucine and isoleucine degradation";"Carbon fixation pathways in prokaryotes";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid salvage";"2-methylpropene degradation";"Tryptophan metabolism";"Aminobenzoate degradation";"beta-Alanine metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Toluene degradation";"Limonene and pinene degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Pyruvate fermentation to butanol II (engineered)";"Fermentation to 2-methylbutanoate";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Pyruvate fermentation to butanol I";"Caprolactam degradation";"Androstenedione degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Spodoptera littoralis pheromone biosynthesis";"Methyl tert-butyl ether degradation";"Propanoate metabolism";"Butanoate metabolism";"4-hydroxybenzoate biosynthesis III (plants)";"Lysine degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"alpha-Linolenic acid metabolism";"Fatty acid elongation";"Geraniol degradation";"Pyruvate fermentation to hexanol (engineered)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Phenylalanine metabolism";"Methyl ketone biosynthesis (engineered)";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Glutaryl-coa degradation"
Mdes019153-RA	10	Reactome: R-HSA-2160916;Reactome: R-HSA-2024096;Reactome: R-HSA-2206292;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23;Reactome: R-HSA-6798695	"Hyaluronan uptake and degradation";"HS-GAG degradation";"MPS VII - Sly syndrome";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Glycosaminoglycan degradation";"Other glycan degradation";"Galactose metabolism";"Neutrophil degranulation"
Mdes007981-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes009697-RA	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
Mdes000343-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes008582-RA	4	Reactome: R-HSA-2467813;Reactome: R-HSA-2470946;Reactome: R-HSA-2500257;Reactome: R-HSA-2468052	"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion";"Establishment of Sister Chromatid Cohesion"
Mdes008512-RA	7	Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-177929;Reactome: R-HSA-1442490;Reactome: R-HSA-2644606;Reactome: R-HSA-2660826	"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Signaling by EGFR";"Collagen degradation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant"
Mdes006241-RA	6	Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385	"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes001847-RA	9	Reactome: R-HSA-5218920;Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-2871796;Reactome: R-HSA-114604;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-2871809	"VEGFR2 mediated vascular permeability";"Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"FCERI mediated MAPK activation";"GPVI-mediated activation cascade";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"FCERI mediated Ca+2 mobilization"
Mdes010894-RA	7	Reactome: R-HSA-70221;MetaCyc: PWY-7238;MetaCyc: PWY-5941;KEGG: 00500+2.4.1.25;MetaCyc: PWY-6724;MetaCyc: PWY-6737;Reactome: R-HSA-6798695	"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II";"Glycogen degradation II";"Starch and sucrose metabolism";"Starch degradation II";"Starch degradation V";"Neutrophil degranulation"
Mdes018692-RA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
Mdes000878-RA	3	KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9;Reactome: R-HSA-5368286	"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"Mitochondrial translation initiation"
Mdes014861-RA	13	MetaCyc: PWY-7220;MetaCyc: PWY-7226;KEGG: 00230+1.17.4.1;MetaCyc: PWY-6545;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7210;MetaCyc: PWY-7184;KEGG: 00480+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-7227;MetaCyc: PWY-7222;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198	"Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV"
Mdes011834-RA	2	Reactome: R-HSA-167827;Reactome: R-HSA-167826	"The proton buffering model";"The fatty acid cycling model"
Mdes007403-RA	7	Reactome: R-HSA-1855204;KEGG: 00562+3.1.3.36;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1855183;MetaCyc: PWY-6368;Reactome: R-HSA-8856828	"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"3-phosphoinositide degradation";"Clathrin-mediated endocytosis"
Mdes019029-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
Mdes004500-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes006584-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes010439-RA	6	Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
Mdes012770-RA	13	MetaCyc: PWY-7721;MetaCyc: PWY-6859;MetaCyc: PWY-5123;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7736;MetaCyc: PWY-7182;MetaCyc: PWY-7410;MetaCyc: PWY-7141;MetaCyc: PWY-6383;MetaCyc: PWY-7709;MetaCyc: PWY-5122;MetaCyc: PWY-7102;MetaCyc: PWY-7659	"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Terpenoid backbone biosynthesis";"Stellatic acid biosynthesis";"Linalool biosynthesis I";"Ipsdienol biosynthesis";"(3S)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"(3R)-linalool biosynthesis";"Geranyl diphosphate biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis"
Mdes013455-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Mdes004204-RA	3	MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3	"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis";"Galactose metabolism"
Mdes009778-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes010593-RA	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
Mdes007671-RA	8	Reactome: R-HSA-6811438;Reactome: R-HSA-380972;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-5628897;Reactome: R-HSA-8854214;Reactome: R-HSA-165181;Reactome: R-HSA-1632852	"Intra-Golgi traffic";"Energy dependent regulation of mTOR by LKB1-AMPK";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"TP53 Regulates Metabolic Genes";"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB";"Macroautophagy"
Mdes004267-RA	5	Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-917977	"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Ion channel transport";"Transferrin endocytosis and recycling"
Mdes018916-RA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6798695;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"Neutrophil degranulation";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes006481-RA	19	MetaCyc: PWY-7176;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7227;MetaCyc: PWY-7184;MetaCyc: PWY-7221;MetaCyc: PWY-7220;MetaCyc: PWY-7224;Reactome: R-HSA-380320;MetaCyc: PWY-7226;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7210;MetaCyc: PWY-6545;MetaCyc: PWY-7187;MetaCyc: PWY-7205;MetaCyc: PWY-7222;MetaCyc: PWY-7198;KEGG: 00240+2.7.4.6;Reactome: R-HSA-380270;MetaCyc: PWY-7197	"UTP and CTP de novo biosynthesis";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Guanosine ribonucleotides de novo biosynthesis";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine deoxyribonucleosides salvage";"Recruitment of NuMA to mitotic centrosomes";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"CMP phosphorylation";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Recruitment of mitotic centrosome proteins and complexes";"Pyrimidine deoxyribonucleotide phosphorylation"
Mdes018107-RA	5	KEGG: 00720+2.7.9.2;MetaCyc: PWY-6142;KEGG: 00680+2.7.9.2;MetaCyc: PWY-5484;KEGG: 00620+2.7.9.2	"Carbon fixation pathways in prokaryotes";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Pyruvate metabolism"
Mdes012707-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes009826-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes000847-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes000465-RA	10	MetaCyc: PWY-8055;MetaCyc: PWY-5667;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.15;MetaCyc: PWY-8053;KEGG: 00564+2.3.1.15;MetaCyc: PWY-7411	"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Anandamide biosynthesis II";"Glycerophospholipid metabolism";"Phosphatidate biosynthesis (yeast)"
Mdes008510-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes007986-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes008809-RB	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes002760-RA	1	Reactome: R-HSA-1296061	"HCN channels"
Mdes006642-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
Mdes007098-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Mdes006633-RA	6	Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220	"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins"
Mdes008886-RA	2	KEGG: 00071+2.3.1.21;MetaCyc: PWY-6111	"Fatty acid degradation";"Mitochondrial L-carnitine shuttle"
Mdes011234-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes019386-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Mdes001478-RA	1	Reactome: R-HSA-6785631	"ERBB2 Regulates Cell Motility"
Mdes004456-RA	8	Reactome: R-HSA-111464;Reactome: R-HSA-6803207;Reactome: R-HSA-111459;Reactome: R-HSA-111458;Reactome: R-HSA-9627069;Reactome: R-HSA-8953750;Reactome: R-HSA-111463;Reactome: R-HSA-6798695	"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Activation of caspases through apoptosome-mediated cleavage";"Formation of apoptosome";"Regulation of the apoptosome activity";"Transcriptional Regulation by E2F6";"SMAC (DIABLO) binds to IAPs";"Neutrophil degranulation"
Mdes004402-RA	13	MetaCyc: PWY-7659;MetaCyc: PWY-7102;MetaCyc: PWY-5122;MetaCyc: PWY-7709;MetaCyc: PWY-6383;MetaCyc: PWY-7141;MetaCyc: PWY-7410;MetaCyc: PWY-7736;MetaCyc: PWY-7182;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-5123;MetaCyc: PWY-7721;MetaCyc: PWY-6859	"Viridicatumtoxin biosynthesis";"Bisabolene biosynthesis (engineered)";"Geranyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"(3S)-linalool biosynthesis";"Ipsdienol biosynthesis";"Stellatic acid biosynthesis";"Linalool biosynthesis I";"Terpenoid backbone biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis"
Mdes012015-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes006620-RA	4	Reactome: R-HSA-5673001;Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-375165	"RAF/MAP kinase cascade";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"NCAM signaling for neurite out-growth"
Mdes008221-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes007760-RA	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
Mdes010105-RC	2	Reactome: R-HSA-975956;Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes001399-RA	5	Reactome: R-HSA-5617472;Reactome: R-HSA-201722;Reactome: R-HSA-3214841;Reactome: R-HSA-3769402;Reactome: R-HSA-8936459	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines";"Deactivation of the beta-catenin transactivating complex";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Mdes016051-RA	4	MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2	"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Lysine degradation"
Mdes003675-RA	6	Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
Mdes010721-RA	4	Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
Mdes002551-RA	4	MetaCyc: PWY-5189;MetaCyc: PWY-5188;KEGG: 00860+4.2.1.75;Reactome: R-HSA-189451	"Tetrapyrrole biosynthesis II (from glycine)";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis"
Mdes006393-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Mdes008019-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes001641-RA	4	Reactome: R-HSA-2214320;Reactome: R-HSA-1650814;Reactome: R-HSA-2243919;Reactome: R-HSA-1474228	"Anchoring fibril formation";"Collagen biosynthesis and modifying enzymes";"Crosslinking of collagen fibrils";"Degradation of the extracellular matrix"
Mdes017060-RA	1	KEGG: 00750+1.1.1.290	"Vitamin B6 metabolism"
Mdes005033-RA	6	Reactome: R-HSA-5626467;Reactome: R-HSA-3769402;Reactome: R-HSA-8957275;Reactome: R-HSA-201722;Reactome: R-HSA-2173796;Reactome: R-HSA-381426	"RHO GTPases activate IQGAPs";"Deactivation of the beta-catenin transactivating complex";"Post-translational protein phosphorylation";"Formation of the beta-catenin:TCF transactivating complex";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
Mdes012604-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Mdes000557-RA	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
Mdes000470-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes012947-RA	5	MetaCyc: PWY-7979;MetaCyc: PWY-7921;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;KEGG: 00515+2.4.1.109	"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Mannose type O-glycan biosynthesis"
Mdes014338-RA	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
Mdes001168-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes009280-RA	4	Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815	"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of PTEN gene transcription";"HDACs deacetylate histones"
Mdes002011-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes002463-RB	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
Mdes001835-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes012531-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-6804758	"HATs acetylate histones";"Regulation of TP53 Activity through Acetylation"
Mdes005710-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes005754-RA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Mdes007179-RA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
Mdes008015-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
Mdes010143-RA	2	Reactome: R-HSA-68962;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress"
Mdes008645-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes017923-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Mdes012202-RA	2	Reactome: R-HSA-2032785;Reactome: R-HSA-8951671	"YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription"
Mdes002889-RC	2	Reactome: R-HSA-5578999;Reactome: R-HSA-174403	"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Glutathione synthesis and recycling"
Mdes004115-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes007737-RA	58	KEGG: 00281+4.2.1.17;Reactome: R-HSA-77348;KEGG: 00360+4.2.1.17;MetaCyc: PWY-7007;MetaCyc: PWY-7216;MetaCyc: PWY-6863;KEGG: 00720+4.2.1.17;Reactome: R-HSA-1482798;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00062+4.2.1.17+1.1.1.211;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;MetaCyc: PWY-7654;MetaCyc: PWY-6435;Reactome: R-HSA-77305;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00362+4.2.1.17;MetaCyc: PWY-7779;KEGG: 00640+4.2.1.17;KEGG: 00592+4.2.1.17;MetaCyc: PWY-5136;KEGG: 00310+4.2.1.17+1.1.1.35;Reactome: R-HSA-77350;MetaCyc: PWY-6945;MetaCyc: PWY-6946;KEGG: 00903+4.2.1.17;KEGG: 00623+1.1.1.35;Reactome: R-HSA-77346;Reactome: R-HSA-77285;MetaCyc: PWY-7656;MetaCyc: PWY-7606;MetaCyc: PWY-5138;MetaCyc: PWY-6944;Reactome: R-HSA-77310;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6583;MetaCyc: PWY-7401;MetaCyc: PWY-5109;KEGG: 00071+4.2.1.17+1.1.1.211;MetaCyc: PWY-6883;KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;Reactome: R-HSA-77288;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00930+4.2.1.17;KEGG: 00380+4.2.1.17;KEGG: 00310+4.2.1.17;KEGG: 00280+4.2.1.17;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-5789;KEGG: 00650+4.2.1.17;KEGG: 00410+4.2.1.17;KEGG: 00627+4.2.1.17;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-7094;MetaCyc: PWY-7726	"Geraniol degradation";"Beta oxidation of octanoyl-CoA to hexanoyl-CoA";"Phenylalanine metabolism";"Methyl ketone biosynthesis (engineered)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Pyruvate fermentation to hexanol (engineered)";"Carbon fixation pathways in prokaryotes";"Acyl chain remodeling of CL";"Geraniol degradation";"Fatty acid elongation";"Fatty acid elongation";"Glutaryl-coa degradation";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"4-hydroxybenzoate biosynthesis III (plants)";"Beta oxidation of palmitoyl-CoA to myristoyl-CoA";"Butanoate metabolism";"Benzoate degradation";"Methyl tert-butyl ether degradation";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Lysine degradation";"Beta oxidation of hexanoyl-CoA to butanoyl-CoA";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Limonene and pinene degradation";"Toluene degradation";"Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA";"Beta oxidation of myristoyl-CoA to lauroyl-CoA";"Spodoptera littoralis pheromone biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Androstenedione degradation";"Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA";"Caprolactam degradation";"Pyruvate fermentation to butanol I";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Fermentation to 2-methylbutanoate";"Fatty acid degradation";"Pyruvate fermentation to butanol II (engineered)";"Carbon fixation pathways in prokaryotes";"Valine, leucine and isoleucine degradation";"Benzoyl-coa degradation I (aerobic)";"mitochondrial fatty acid beta-oxidation of unsaturated fatty acids";"Benzoate degradation";"Caprolactam degradation";"Tryptophan metabolism";"Lysine degradation";"Valine, leucine and isoleucine degradation";"Fatty acid degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Butanoate metabolism";"beta-Alanine metabolism";"Aminobenzoate degradation";"Tryptophan metabolism";"2-methylpropene degradation";"Fatty acid salvage";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"
Mdes001983-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Mdes016336-RA	6	Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-450385	"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes014090-RA	28	Reactome: R-HSA-5685942;Reactome: R-HSA-5651801;Reactome: R-HSA-3371511;Reactome: R-HSA-5685938;Reactome: R-HSA-6783310;Reactome: R-HSA-69166;Reactome: R-HSA-3371453;Reactome: R-HSA-5696395;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-5656121;Reactome: R-HSA-5358565;Reactome: R-HSA-6804756;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5358606;Reactome: R-HSA-912446;Reactome: R-HSA-110320;Reactome: R-HSA-110312;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-5693616;Reactome: R-HSA-110314;Reactome: R-HSA-174437;Reactome: R-HSA-68962	"HDR through Homologous Recombination (HRR)";"PCNA-Dependent Long Patch Base Excision Repair";"HSF1 activation";"HDR through Single Strand Annealing (SSA)";"Fanconi Anemia Pathway";"Removal of the Flap Intermediate";"Regulation of HSF1-mediated heat shock response";"Formation of Incision Complex in GG-NER";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"Translesion synthesis by POLI";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Regulation of TP53 Activity through Phosphorylation";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Meiotic recombination";"Translesion Synthesis by POLH";"Translesion synthesis by REV1";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate from the C-strand";"Activation of the pre-replicative complex"
Mdes007322-RB	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
Mdes002656-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes011605-RA	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
Mdes009955-RA	8	Reactome: R-HSA-68884;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-1855183;KEGG: 00053+1.13.99.1;KEGG: 00562+1.13.99.1;MetaCyc: PWY-4841;Reactome: R-HSA-6811434	"Mitotic Telophase/Cytokinesis";"Kinesins";"MHC class II antigen presentation";"Synthesis of IP2, IP, and Ins in the cytosol";"Ascorbate and aldarate metabolism";"Inositol phosphate metabolism";"UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes014163-RA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
Mdes004790-RB	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Mdes015601-RA	10	KEGG: 00430+2.3.2.2;MetaCyc: PWY-4061;MetaCyc: PWY-8001;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-6842;MetaCyc: PWY-7559;MetaCyc: PWY-4041;MetaCyc: PWY-5826;MetaCyc: PWY-7112;KEGG: 00460+2.3.2.2	"Taurine and hypotaurine metabolism";"Glutathione-mediated detoxification I";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione metabolism";"Glutathione-mediated detoxification II";"Glutathione degradation (DUG pathway";"Gamma-glutamyl cycle";"Hypoglycin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Cyanoamino acid metabolism"
Mdes001422-RA	6	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72649	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation"
Mdes012213-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Mdes009621-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes008654-RA	10	KEGG: 04070+2.7.1.153;KEGG: 04151+2.7.1.153;KEGG: 05165+2.7.1.153;MetaCyc: PWY-6352;Reactome: R-HSA-9027276;Reactome: R-HSA-1660499;KEGG: 05163+2.7.1.153;KEGG: 00562+2.7.1.153;KEGG: 04150+2.7.1.153;KEGG: 05170+2.7.1.153	"Phosphatidylinositol signaling system";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"3-phosphoinositide biosynthesis";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"Synthesis of PIPs at the plasma membrane";"Human cytomegalovirus infection";"Inositol phosphate metabolism";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
Mdes008809-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes010659-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes016904-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes004994-RA	1	Reactome: R-HSA-446203	"Asparagine N-linked glycosylation"
Mdes009214-RA	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
Mdes009181-RA	4	Reactome: R-HSA-379716;KEGG: 00450+6.1.1.10;Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.10	"Cytosolic tRNA aminoacylation";"Selenocompound metabolism";"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis"
Mdes011026-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Mdes009198-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450385	"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes002001-RA	3	Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840	"G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle"
Mdes005809-RA	3	Reactome: R-HSA-74259;Reactome: R-HSA-73621;Reactome: R-HSA-196807	"Purine catabolism";"Pyrimidine catabolism";"Nicotinate metabolism"
Mdes002819-RA	3	Reactome: R-HSA-1483191;Reactome: R-HSA-422085;Reactome: R-HSA-112311	"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin";"Neurotransmitter clearance"
Mdes010085-RC	11	Reactome: R-HSA-400253;Reactome: R-HSA-212436;Reactome: R-HSA-2426168;Reactome: R-HSA-1368108;Reactome: R-HSA-383280;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-2151201;Reactome: R-HSA-400206;Reactome: R-HSA-381340;Reactome: R-HSA-1368082	"Circadian Clock";"Generic Transcription Pathway";"Activation of gene expression by SREBF (SREBP)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nuclear Receptor transcription pathway";"PPARA activates gene expression";"Estrogen-dependent gene expression";"Transcriptional activation of mitochondrial biogenesis";"Regulation of lipid metabolism by PPARalpha";"Transcriptional regulation of white adipocyte differentiation";"RORA activates gene expression"
Mdes001130-RB	4	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-72764	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination"
Mdes002989-RA	8	MetaCyc: PWY-7198;MetaCyc: PWY-7184;Reactome: R-HSA-499943;MetaCyc: PWY-7210;MetaCyc: PWY-6545;MetaCyc: PWY-7187;MetaCyc: PWY-7197;KEGG: 00240+2.7.4.9	"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine metabolism"
Mdes014378-RA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
Mdes006230-RD	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
Mdes003087-RB	3	Reactome: R-HSA-1810476;Reactome: R-HSA-445989;Reactome: R-HSA-933542	"RIP-mediated NFkB activation via ZBP1";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TRAF6 mediated NF-kB activation"
Mdes011430-RA	8	Reactome: R-HSA-9639288;MetaCyc: PWY-7980;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-77387;KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;Reactome: R-HSA-983712	"Amino acids regulate mTORC1";"ATP biosynthesis";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Photosynthesis";"Oxidative phosphorylation";"Ion channel transport"
Mdes005024-RA	9	MetaCyc: PWY-5789;Reactome: R-HSA-1475029;MetaCyc: PWY-7115;MetaCyc: PWY-241;MetaCyc: PWY-5744;MetaCyc: PWY-5743;KEGG: 00910+4.2.1.1;MetaCyc: PWY-6142;MetaCyc: PWY-7117	"3-hydroxypropanoate/4-hydroxybutanate cycle";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Glyoxylate assimilation";"3-hydroxypropanoate cycle";"Nitrogen metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, PEPCK type"
Mdes007774-RB	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
Mdes004073-RA	7	Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380270	"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes"
Mdes011159-RA	6	Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
Mdes001511-RA	6	KEGG: 04658+3.1.3.16;Reactome: R-HSA-5693565;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-5675221;Reactome: R-HSA-8939211	"Th1 and Th2 cell differentiation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Negative regulation of MAPK pathway";"ESR-mediated signaling"
Mdes008319-RB	3	Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-1358803	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Downregulation of ERBB2:ERBB3 signaling"
Mdes001254-RA	2	KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386	"Pyruvate metabolism";"Methylglyoxal degradation I"
Mdes010959-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes006894-RA	2	Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
Mdes009777-RA	3	KEGG: 00510+2.4.1.117;Reactome: R-HSA-913709;Reactome: R-HSA-480985	"N-Glycan biosynthesis";"O-linked glycosylation of mucins";"Synthesis of dolichyl-phosphate-glucose"
Mdes002849-RA	3	KEGG: 00900+2.5.1.58;Reactome: R-HSA-203927;Reactome: R-HSA-2514859	"Terpenoid backbone biosynthesis";"MicroRNA (miRNA) biogenesis";"Inactivation, recovery and regulation of the phototransduction cascade"
Mdes011649-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes005330-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes007218-RA	24	Reactome: R-HSA-416476;Reactome: R-HSA-400042;Reactome: R-HSA-420092;Reactome: R-HSA-392170;Reactome: R-HSA-6814122;Reactome: R-HSA-8964315;Reactome: R-HSA-392851;Reactome: R-HSA-418555;Reactome: R-HSA-432040;Reactome: R-HSA-392451;Reactome: R-HSA-418594;Reactome: R-HSA-163359;Reactome: R-HSA-500657;Reactome: R-HSA-418217;Reactome: R-HSA-456926;Reactome: R-HSA-416482;Reactome: R-HSA-418597;Reactome: R-HSA-8964616;Reactome: R-HSA-9009391;Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-4086398;Reactome: R-HSA-202040;Reactome: R-HSA-381676	"G alpha (q) signalling events";"Adrenaline,noradrenaline inhibits insulin secretion";"Glucagon-type ligand receptors";"ADP signalling through P2Y purinoceptor 12";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through BTK";"Prostacyclin signalling through prostacyclin receptor";"G alpha (s) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through PI3Kgamma";"G alpha (i) signalling events";"Glucagon signaling in metabolic regulation";"Presynaptic function of Kainate receptors";"G beta:gamma signalling through PLC beta";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (12/13) signalling events";"G alpha (z) signalling events";"G beta:gamma signalling through CDC42";"Extra-nuclear estrogen signaling";"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"Ca2+ pathway";"G-protein activation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"
Mdes019387-RA	15	Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-8936459;Reactome: R-HSA-5628897;Reactome: R-HSA-8853884;Reactome: R-HSA-4086398;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-9022692;Reactome: R-HSA-2559580;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569	"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by VENTX";"Ca2+ pathway";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of MECP2 expression and activity";"Oxidative Stress Induced Senescence";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
Mdes012291-RA	6	KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;Reactome: R-HSA-114508	"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis"
Mdes000639-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Mdes009718-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes004655-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Mdes004745-RB	17	Reactome: R-HSA-69183;Reactome: R-HSA-5685942;Reactome: R-HSA-5651801;Reactome: R-HSA-69166;Reactome: R-HSA-5696400;Reactome: R-HSA-5358565;Reactome: R-HSA-5358606;Reactome: R-HSA-69091;Reactome: R-HSA-174414;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-174417;Reactome: R-HSA-174437;Reactome: R-HSA-110314	"Processive synthesis on the lagging strand";"HDR through Homologous Recombination (HRR)";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"Dual Incision in GG-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Polymerase switching";"Processive synthesis on the C-strand of the telomere";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Removal of the Flap Intermediate from the C-strand";"Recognition of DNA damage by PCNA-containing replication complex"
Mdes019561-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-5628897	"Glutathione metabolism";"TP53 Regulates Metabolic Genes"
Mdes007176-RC	4	MetaCyc: PWY-7546;MetaCyc: PWY-6482;Reactome: R-HSA-5358493;Reactome: R-HSA-8849175	"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)";"Synthesis of diphthamide-EEF2";"Threonine catabolism"
Mdes015727-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Mdes001576-RA	1	Reactome: R-HSA-427601	"Multifunctional anion exchangers"
Mdes013667-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Mdes009142-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes000202-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes014118-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes003571-RB	8	KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1	"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Major pathway of rRNA processing in the nucleolus and cytosol";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection"
Mdes006272-RB	8	Reactome: R-HSA-1483148;KEGG: 04658+3.1.3.16;MetaCyc: PWY-5269;KEGG: 00564+3.1.3.27;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;MetaCyc: PWY-5668;MetaCyc: PWY-7817	"Synthesis of PG";"Th1 and Th2 cell differentiation";"Cardiolipin biosynthesis II";"Glycerophospholipid metabolism";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Cardiolipin biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)"
Mdes007560-RB	4	Reactome: R-HSA-3000178;Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"ECM proteoglycans";"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
Mdes001732-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Mdes013985-RB	7	MetaCyc: PWY-7445;MetaCyc: PWY-5461;MetaCyc: PWY-7214;MetaCyc: PWY-5466;MetaCyc: PWY-5469;MetaCyc: PWY-6824;KEGG: 00940+1.11.1.7	"Luteolin triglucuronide degradation";"Betanidin degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Matairesinol biosynthesis";"Sesamin biosynthesis";"Justicidin B biosynthesis";"Phenylpropanoid biosynthesis"
Mdes010975-RA	1	Reactome: R-HSA-8876725	"Protein methylation"
Mdes017397-RA	7	Reactome: R-HSA-1834949;Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-73980	"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination"
Mdes002541-RB	3	Reactome: R-HSA-4090294;Reactome: R-HSA-3232118;Reactome: R-HSA-3899300	"SUMOylation of intracellular receptors";"SUMOylation of transcription factors";"SUMOylation of transcription cofactors"
Mdes008525-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes003300-RC	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes009302-RB	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Mdes013232-RA	6	Reactome: R-HSA-5684045;Reactome: R-HSA-2046106;Reactome: R-HSA-1369062;Reactome: R-HSA-390247;Reactome: R-HSA-2046105;Reactome: R-HSA-9603798	"Defective ABCD1 causes adrenoleukodystrophy (ALD)";"alpha-linolenic acid (ALA) metabolism";"ABC transporters in lipid homeostasis";"Beta-oxidation of very long chain fatty acids";"Linoleic acid (LA) metabolism";"Class I peroxisomal membrane protein import"
Mdes001361-RA	4	Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823	"Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex"
Mdes001605-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes006438-RA	7	MetaCyc: PWY-6367;MetaCyc: PWY-6351;KEGG: 04070+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-8052;KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204	"D-myo-inositol-5-phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system";"Phosphatidate metabolism, as a signaling molecule";"2-arachidonoylglycerol biosynthesis";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol"
Mdes018034-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes002920-RA	14	MetaCyc: PWY-5690;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-7279;KEGG: 00720+1.3.5.1;KEGG: 00190+1.3.5.1;KEGG: 00020+1.3.5.1;MetaCyc: PWY-7254;KEGG: 00650+1.3.5.1;MetaCyc: PWY-6969;Reactome: R-HSA-611105;MetaCyc: PWY-3781;MetaCyc: PWY-561;MetaCyc: PWY-4302	"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Aerobic respiration II (cytochrome c) (yeast)";"Carbon fixation pathways in prokaryotes";"Oxidative phosphorylation";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Butanoate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Respiratory electron transport";"Aerobic respiration I (cytochrome c)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration III (alternative oxidase pathway)"
Mdes014036-RA	8	Reactome: R-HSA-4551638;Reactome: R-HSA-8953750;Reactome: R-HSA-8943724;Reactome: R-HSA-5617472;Reactome: R-HSA-9609690;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-3214841	"SUMOylation of chromatin organization proteins";"Transcriptional Regulation by E2F6";"Regulation of PTEN gene transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HCMV Early Events";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"PKMTs methylate histone lysines"
Mdes009140-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5689880	"UCH proteinases";"Ub-specific processing proteases"
Mdes005103-RA	1	Reactome: R-HSA-211897	"Cytochrome P450 - arranged by substrate type"
Mdes001440-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes008319-RA	3	Reactome: R-HSA-1358803;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes011392-RA	11	Reactome: R-HSA-164378;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-163359;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-170660;Reactome: R-HSA-432040	"PKA activation in glucagon signalling";"PKA activation";"Hedgehog 'off' state";"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"G alpha (s) signalling events";"G alpha (z) signalling events";"G alpha (i) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins"
Mdes005105-RA	9	Reactome: R-HSA-8951664;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-5696400;Reactome: R-HSA-5696395;Reactome: R-HSA-6781827	"Neddylation";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
Mdes001829-RA	6	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-2173788;KEGG: 05235+3.1.3.16;Reactome: R-HSA-400253;Reactome: R-HSA-163560	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"Downregulation of TGF-beta receptor signaling";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Circadian Clock";"Triglyceride catabolism"
Mdes001028-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes002340-RA	6	Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-72163;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6798695	"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Major Pathway";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Neutrophil degranulation"
Mdes016492-RA	3	MetaCyc: PWY-7887;Reactome: R-HSA-6787450;MetaCyc: PWY-7892	"Protein SAMPylation and SAMP-mediated thiolation";"tRNA modification in the mitochondrion";"Trna-uridine 2-thiolation and selenation (bacteria)"
Mdes009969-RA	19	Reactome: R-HSA-8856828;Reactome: R-HSA-8957275;Reactome: R-HSA-8963901;Reactome: R-HSA-975634;Reactome: R-HSA-8964038;Reactome: R-HSA-202733;Reactome: R-HSA-8964046;Reactome: R-HSA-8856825;Reactome: R-HSA-3000471;Reactome: R-HSA-8963888;Reactome: R-HSA-3000497;Reactome: R-HSA-8964026;Reactome: R-HSA-3000480;Reactome: R-HSA-432142;Reactome: R-HSA-5686938;Reactome: R-HSA-3000484;Reactome: R-HSA-8866423;Reactome: R-HSA-381426;Reactome: R-HSA-8964041	"Clathrin-mediated endocytosis";"Post-translational protein phosphorylation";"Chylomicron remodeling";"Retinoid metabolism and transport";"LDL clearance";"Cell surface interactions at the vascular wall";"VLDL clearance";"Cargo recognition for clathrin-mediated endocytosis";"Scavenging by Class B Receptors";"Chylomicron assembly";"Scavenging by Class H Receptors";"Chylomicron clearance";"Scavenging by Class A Receptors";"Platelet sensitization by LDL";"Regulation of TLR by endogenous ligand";"Scavenging by Class F Receptors";"VLDL assembly";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"LDL remodeling"
Mdes016564-RA	57	Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-4641257;Reactome: R-HSA-5668541;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-5362768;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-180534;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-5687128;Reactome: R-HSA-6798695;Reactome: R-HSA-450408;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858	"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Neddylation";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of AXIN";"TNFR2 non-canonical NF-kB pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Vpu mediated degradation of CD4";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Ub-specific processing proteases";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"MAPK6/MAPK4 signaling";"Neutrophil degranulation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity"
Mdes001133-RA	27	Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-168276;Reactome: R-HSA-159230;Reactome: R-HSA-3108214;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-180910;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-168325	"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"HCMV Late Events";"Vpr-mediated nuclear import of PICs";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis"
Mdes018461-RA	2	Reactome: R-HSA-532668;KEGG: 00511+3.2.1.96	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Other glycan degradation"
Mdes018352-RA	7	MetaCyc: PWY-7308;KEGG: 00380+4.2.1.84;KEGG: 00364+4.2.1.84;MetaCyc: PWY-5025;MetaCyc: PWY-581;KEGG: 00627+4.2.1.84;KEGG: 00643+4.2.1.84	"Acrylonitrile degradation I";"Tryptophan metabolism";"Fluorobenzoate degradation";"Indole-3-acetate biosynthesis IV (bacteria)";"Indole-3-acetate biosynthesis II";"Aminobenzoate degradation";"Styrene degradation"
Mdes017973-RA	6	Reactome: R-HSA-196780;MetaCyc: PWY-5743;MetaCyc: PWY-5744;MetaCyc: PWY-6722;MetaCyc: PWY-5789;MetaCyc: PWY-4381	"Biotin transport and metabolism";"3-hydroxypropanoate cycle";"Glyoxylate assimilation";"Candicidin biosynthesis";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Fatty acid biosynthesis initiation (bacteria and plants)"
Mdes008244-RA	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
Mdes003251-RA	9	KEGG: 00130+2.6.1.5;KEGG: 00950+2.6.1.5;KEGG: 00401+2.6.1.5;KEGG: 00400+2.6.1.5;KEGG: 00960+2.6.1.5;KEGG: 00360+2.6.1.5;Reactome: R-HSA-8963684;KEGG: 00350+2.6.1.5;KEGG: 00270+2.6.1.5	"Ubiquinone and other terpenoid-quinone biosynthesis";"Isoquinoline alkaloid biosynthesis";"Novobiocin biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Phenylalanine metabolism";"Tyrosine catabolism";"Tyrosine metabolism";"Cysteine and methionine metabolism"
Mdes016509-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes008108-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Mdes006590-RA	2	Reactome: R-HSA-9610379;Reactome: R-HSA-917729	"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)"
Mdes016928-RA	2	Reactome: R-HSA-432720;Reactome: R-HSA-432722	"Lysosome Vesicle Biogenesis";"Golgi Associated Vesicle Biogenesis"
Mdes001037-RA	6	Reactome: R-HSA-6787450;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470;MetaCyc: PWY-7285;MetaCyc: PWY-7286;MetaCyc: PWY-6829	"tRNA modification in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion";"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Trna methylation (yeast)"
Mdes013591-RD	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes007605-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Mdes007559-RA	60	Reactome: R-HSA-5362768;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;KEGG: 00590+5.3.99.3;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-5668541;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-180534;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-6798695;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-499943;Reactome: R-HSA-5678895;Reactome: R-HSA-187577;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-68949;Reactome: R-HSA-2162123;Reactome: R-HSA-195253	"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"Arachidonic acid metabolism";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"TNFR2 non-canonical NF-kB pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Vpu mediated degradation of CD4";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Ub-specific processing proteases";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"Neutrophil degranulation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"UCH proteinases";"Interconversion of nucleotide di- and triphosphates";"Defective CFTR causes cystic fibrosis";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Orc1 removal from chromatin";"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)";"Degradation of beta-catenin by the destruction complex"
Mdes013154-RA	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
Mdes003759-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes000087-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes013095-RA	8	Reactome: R-HSA-5659996;Reactome: R-HSA-71336;KEGG: 00030+5.3.1.6;Reactome: R-HSA-6791461;KEGG: 00051+5.3.1.6;KEGG: 00710+5.3.1.6;MetaCyc: PWY-1861;MetaCyc: PWY-5723	"RPIA deficiency: failed conversion of R5P to RU5P";"Pentose phosphate pathway";"Pentose phosphate pathway";"RPIA deficiency: failed conversion of RU5P to R5P";"Fructose and mannose metabolism";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Rubisco shunt"
Mdes005601-RA	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.20	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes009877-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes005213-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Mdes002353-RA	14	MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-5972;MetaCyc: PWY-7602	"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"
Mdes011268-RA	58	Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-5687128;Reactome: R-HSA-6798695;Reactome: R-HSA-450408;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-5668541;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-611105;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178	"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"MAPK6/MAPK4 signaling";"Neutrophil degranulation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Neddylation";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"TNFR2 non-canonical NF-kB pathway";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Respiratory electron transport";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
Mdes001280-RA	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
Mdes006369-RA	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
Mdes003922-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes006883-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes008878-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes004000-RA	11	Reactome: R-HSA-1963642;Reactome: R-HSA-8863795;Reactome: R-HSA-6785631;Reactome: R-HSA-8847993;Reactome: R-HSA-6811558;Reactome: R-HSA-9664565;Reactome: R-HSA-1250196;Reactome: R-HSA-5673001;Reactome: R-HSA-1257604;Reactome: R-HSA-2219530;Reactome: R-HSA-1227986	"PI3K events in ERBB2 signaling";"Downregulation of ERBB2 signaling";"ERBB2 Regulates Cell Motility";"ERBB2 Activates PTK6 Signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB2 signaling";"RAF/MAP kinase cascade";"PIP3 activates AKT signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Signaling by ERBB2"
Mdes013012-RA	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
Mdes017697-RA	2	MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33	"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis"
Mdes007142-RA	5	KEGG: 00250+6.3.5.4;Reactome: R-HSA-380994;Reactome: R-HSA-9648895;Reactome: R-HSA-8963693;Reactome: R-HSA-9633012	"Alanine, aspartate and glutamate metabolism";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK1 (HRI) to heme deficiency";"Aspartate and asparagine metabolism";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes006803-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Mdes009534-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes005079-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes003882-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes000082-RA	13	Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes005397-RA	6	MetaCyc: PWY-7656;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
Mdes001281-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes009338-RA	11	Reactome: R-HSA-164378;Reactome: R-HSA-163615;Reactome: R-HSA-418555;Reactome: R-HSA-418597;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418594;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-5610787;Reactome: R-HSA-163359;Reactome: R-HSA-170670	"PKA activation in glucagon signalling";"PKA activation";"G alpha (s) signalling events";"G alpha (z) signalling events";"Purine metabolism";"G alpha (i) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state";"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway"
Mdes007352-RA	4	MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-6902	"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)"
Mdes010468-RB	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Mdes010376-RA	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440	"RAB GEFs exchange GTP for GDP on RABs";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network"
Mdes012754-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Mdes006311-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes017116-RA	40	MetaCyc: PWY-7656;MetaCyc: PWY-7606;MetaCyc: PWY-5138;MetaCyc: PWY-6944;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-7401;MetaCyc: PWY-6583;MetaCyc: PWY-5109;MetaCyc: PWY-6883;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6945;MetaCyc: PWY-6946;KEGG: 00623+1.1.1.35;MetaCyc: PWY-5789;KEGG: 00410+4.2.1.17;KEGG: 00627+4.2.1.17;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-7094;MetaCyc: PWY-7726;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;MetaCyc: PWY-7654;MetaCyc: PWY-7007;KEGG: 00360+4.2.1.17;MetaCyc: PWY-6863;MetaCyc: PWY-7216;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00592+4.2.1.17;MetaCyc: PWY-5136;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;MetaCyc: PWY-7779	"Spodoptera littoralis pheromone biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Androstenedione degradation";"Caprolactam degradation";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Pyruvate fermentation to butanol I";"Fermentation to 2-methylbutanoate";"Pyruvate fermentation to butanol II (engineered)";"Limonene and pinene degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Toluene degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"beta-Alanine metabolism";"Aminobenzoate degradation";"Tryptophan metabolism";"2-methylpropene degradation";"Fatty acid salvage";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Carbon fixation pathways in prokaryotes";"Benzoyl-coa degradation I (aerobic)";"Valine, leucine and isoleucine degradation";"Benzoate degradation";"Fatty acid degradation";"Glutaryl-coa degradation";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Methyl ketone biosynthesis (engineered)";"Phenylalanine metabolism";"Pyruvate fermentation to hexanol (engineered)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Geraniol degradation";"Fatty acid elongation";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Lysine degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Butanoate metabolism";"Propanoate metabolism";"Methyl tert-butyl ether degradation"
Mdes004024-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes017207-RA	3	Reactome: R-HSA-5617472;Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Mdes003690-RH	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Mdes000405-RA	14	MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6433	"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)"
Mdes017574-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes002216-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Mdes014730-RA	5	Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-983231;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Factors involved in megakaryocyte development and platelet production";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic"
Mdes004413-RA	3	KEGG: 00310+1.14.11.8;MetaCyc: PWY-6100;Reactome: R-HSA-71262	"Lysine degradation";"L-carnitine biosynthesis";"Carnitine synthesis"
Mdes012500-RA	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Mdes007451-RA	69	Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;MetaCyc: PWY-8086;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;MetaCyc: PWY-7384;Reactome: R-HSA-5610783;KEGG: 00620+4.2.1.2;Reactome: R-HSA-68949;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-2467813;MetaCyc: PWY-5690;MetaCyc: PWY-5913;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;MetaCyc: PWY-7254;Reactome: R-HSA-1234176;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;KEGG: 00020+4.2.1.2;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-71403;Reactome: R-HSA-9604323;Reactome: R-HSA-8852276;Reactome: R-HSA-174154;Reactome: R-HSA-180534;MetaCyc: PWY-6728;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-211733;MetaCyc: PWY-561;Reactome: R-HSA-195253;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;KEGG: 00720+4.2.1.2;Reactome: R-HSA-174178;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;MetaCyc: PWY-5392;MetaCyc: PWY-6969;Reactome: R-HSA-4641257;Reactome: R-HSA-180585;Reactome: R-HSA-5668541	"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Hedgehog 'on' state";"Ub-specific processing proteases";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Degradation of GLI2 by the proteasome";"Pyruvate metabolism";"Orc1 removal from chromatin";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"UCH proteinases";"Separation of Sister Chromatids";"TCA cycle II (plants and fungi)";"Partial TCA cycle (obligate autotrophs)";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"TCA cycle VII (acetate-producers)";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Citrate cycle (TCA cycle)";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Citric acid cycle (TCA cycle)";"Negative regulation of NOTCH4 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"Methylaspartate cycle";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Superpathway of glyoxylate cycle and fatty acid degradation";"Degradation of beta-catenin by the destruction complex";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"Carbon fixation pathways in prokaryotes";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Reductive TCA cycle II";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Degradation of AXIN";"Vif-mediated degradation of APOBEC3G";"TNFR2 non-canonical NF-kB pathway"
Mdes009302-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Mdes009263-RA	27	Reactome: R-HSA-170822;Reactome: R-HSA-4615885;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-3371453;Reactome: R-HSA-168333;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-180746	"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA replication proteins";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"Regulation of HSF1-mediated heat shock response";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"Transcriptional regulation by small RNAs";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein"
Mdes007428-RB	3	Reactome: R-HSA-8868766;Reactome: R-HSA-6785470;Reactome: R-HSA-6784531	"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion";"tRNA processing in the nucleus"
Mdes001582-RB	1	MetaCyc: PWY-7437	"Protein O-[N-acetyl]-glucosylation"
Mdes008406-RA	2	Reactome: R-HSA-191859;Reactome: R-HSA-5624958	"snRNP Assembly";"ARL13B-mediated ciliary trafficking of INPP5E"
Mdes003690-RJ	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
Mdes002839-RA	57	Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-6798695;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-5607764;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-5668541	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Neutrophil degranulation";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CLEC7A (Dectin-1) signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"Hedgehog 'on' state";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Neddylation";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"TNFR2 non-canonical NF-kB pathway"
Mdes018128-RA	1	KEGG: 00970+6.1.1.14	"Aminoacyl-tRNA biosynthesis"
Mdes011851-RA	7	Reactome: R-HSA-204174;Reactome: R-HSA-5362517;Reactome: R-HSA-70268;Reactome: R-HSA-389661;KEGG: 00620+2.3.1.12;KEGG: 00020+2.3.1.12;KEGG: 00010+2.3.1.12	"Regulation of pyruvate dehydrogenase (PDH) complex";"Signaling by Retinoic Acid";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Glycolysis / Gluconeogenesis"
Mdes013510-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes012827-RA	3	Reactome: R-HSA-1236974;Reactome: R-HSA-1799339;Reactome: R-HSA-9609523	"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Mdes002670-RA	3	Reactome: R-HSA-6783310;Reactome: R-HSA-110314;Reactome: R-HSA-5689880	"Fanconi Anemia Pathway";"Recognition of DNA damage by PCNA-containing replication complex";"Ub-specific processing proteases"
Mdes000394-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes009705-RA	3	Reactome: R-HSA-5632968;Reactome: R-HSA-5632928;Reactome: R-HSA-5358565	"Defective Mismatch Repair Associated With MSH6";"Defective Mismatch Repair Associated With MSH2";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"
Mdes015255-RA	16	Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764	"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination"
Mdes011498-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes007751-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes002791-RA	5	MetaCyc: PWY-6012;MetaCyc: PWY-6012-1;MetaCyc: PWY-6289;KEGG: 00770+2.7.8.7;Reactome: R-HSA-199220	"Acyl carrier protein metabolism";"Acyl carrier protein activation";"Petrobactin biosynthesis";"Pantothenate and CoA biosynthesis";"Vitamin B5 (pantothenate) metabolism"
Mdes001354-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689	"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits"
Mdes017186-RA	6	Reactome: R-HSA-2022090;Reactome: R-HSA-1650814;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Assembly of collagen fibrils and other multimeric structures";"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization";"Collagen degradation";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
Mdes009848-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6784531	"Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus"
Mdes003995-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes000452-RC	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
Mdes018404-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes017300-RB	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes010667-RA	5	MetaCyc: PWY-6277;MetaCyc: PWY-6121;KEGG: 00230+6.3.5.3;MetaCyc: PWY-6122;Reactome: R-HSA-73817	"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis"
Mdes005590-RA	3	Reactome: R-HSA-5658442;Reactome: R-HSA-379726;KEGG: 00970+6.1.1.20	"Regulation of RAS by GAPs";"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes005183-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Mdes018722-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes014635-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Mdes000997-RB	1	Reactome: R-HSA-8949613	"Cristae formation"
Mdes006199-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes009828-RA	4	Reactome: R-HSA-74217;Reactome: R-HSA-2672351;KEGG: 00230+2.7.1.20;MetaCyc: PWY-6619	"Purine salvage";"Stimuli-sensing channels";"Purine metabolism";"Adenine and adenosine salvage VI"
Mdes008731-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Mdes002602-RA	2	Reactome: R-HSA-2151201;Reactome: R-HSA-400253	"Transcriptional activation of mitochondrial biogenesis";"Circadian Clock"
Mdes006198-RA	3	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
Mdes003369-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes011060-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes002037-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
Mdes008594-RD	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes007692-RA	3	Reactome: R-HSA-379716;Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.4	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis"
Mdes009235-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Mdes004637-RA	6	Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition"
Mdes012202-RB	2	Reactome: R-HSA-8951671;Reactome: R-HSA-2032785	"RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression"
Mdes003831-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes005519-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes006979-RA	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
Mdes008681-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Mdes002571-RA	2	Reactome: R-HSA-6807505;Reactome: R-HSA-1632852	"RNA polymerase II transcribes snRNA genes";"Macroautophagy"
Mdes013641-RC	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
Mdes019289-RA	7	KEGG: 00550+2.7.8.13;KEGG: 00510+2.7.8.15;MetaCyc: PWY-5265;Reactome: R-HSA-4549356;Reactome: R-HSA-446193;MetaCyc: PWY-6471;MetaCyc: PWY-6470	"Peptidoglycan biosynthesis";"N-Glycan biosynthesis";"Peptidoglycan biosynthesis II (staphylococci)";"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Peptidoglycan biosynthesis V (beta-lactam resistance)"
Mdes005960-RA	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
Mdes012399-RA	3	KEGG: 00232+1.7.3.3;MetaCyc: PWY-5691;KEGG: 00230+1.7.3.3	"Caffeine metabolism";"Urate conversion to allantoin I";"Purine metabolism"
Mdes018650-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes000944-RC	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes003604-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes000746-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes004202-RA	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
Mdes004170-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Mdes001801-RA	3	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Tight junction interactions"
Mdes005730-RA	7	Reactome: R-HSA-380320;KEGG: 00250+2.6.1.16;KEGG: 00520+2.6.1.16;MetaCyc: PWY-6749;MetaCyc: PWY-8013;Reactome: R-HSA-380270;Reactome: R-HSA-446210	"Recruitment of NuMA to mitotic centrosomes";"Alanine, aspartate and glutamate metabolism";"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Recruitment of mitotic centrosome proteins and complexes";"Synthesis of UDP-N-acetyl-glucosamine"
Mdes000821-RA	18	Reactome: R-HSA-5693607;Reactome: R-HSA-3270619;Reactome: R-HSA-912446;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693548;Reactome: R-HSA-5685938;Reactome: R-HSA-5693565;Reactome: R-HSA-5693616;Reactome: R-HSA-1834949;Reactome: R-HSA-2559586;Reactome: R-HSA-5685939;Reactome: R-HSA-6782315;Reactome: R-HSA-5693554	"Processing of DNA double-strand break ends";"IRF3-mediated induction of type I IFN";"Meiotic recombination";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Sensing of DNA Double Strand Breaks";"HDR through Single Strand Annealing (SSA)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Presynaptic phase of homologous DNA pairing and strand exchange";"Cytosolic sensors of pathogen-associated DNA";"DNA Damage/Telomere Stress Induced Senescence";"HDR through MMEJ (alt-NHEJ)";"tRNA modification in the nucleus and cytosol";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
Mdes017503-RA	5	MetaCyc: PWY-6385;MetaCyc: PWY-5265;MetaCyc: PWY-6470;KEGG: 00550+2.4.1.129;MetaCyc: PWY-6471	"Peptidoglycan biosynthesis III (mycobacteria)";"Peptidoglycan biosynthesis II (staphylococci)";"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis";"Peptidoglycan biosynthesis IV (Enterococcus faecium)"
Mdes003063-RA	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Mdes010416-RA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
Mdes016572-RA	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
Mdes007906-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes002098-RA	3	Reactome: R-HSA-1483191;Reactome: R-HSA-422085;Reactome: R-HSA-112311	"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin";"Neurotransmitter clearance"
Mdes018558-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes005746-RB	7	Reactome: R-HSA-6799198;Reactome: R-HSA-6811438;Reactome: R-HSA-611105;Reactome: R-HSA-6811440;Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-6807878	"Complex I biogenesis";"Intra-Golgi traffic";"Respiratory electron transport";"Retrograde transport at the Trans-Golgi-Network";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"COPI-mediated anterograde transport"
Mdes001239-RA	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
Mdes008622-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes001443-RA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes006944-RA	10	Reactome: R-HSA-611105;Reactome: R-HSA-111463;Reactome: R-HSA-5628897;Reactome: R-HSA-9627069;Reactome: R-HSA-111458;Reactome: R-HSA-111457;Reactome: R-HSA-111459;Reactome: R-HSA-111464;Reactome: R-HSA-2151201;Reactome: R-HSA-3299685	"Respiratory electron transport";"SMAC (DIABLO) binds to IAPs";"TP53 Regulates Metabolic Genes";"Regulation of the apoptosome activity";"Formation of apoptosome";"Release of apoptotic factors from the mitochondria";"Activation of caspases through apoptosome-mediated cleavage";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Transcriptional activation of mitochondrial biogenesis";"Detoxification of Reactive Oxygen Species"
Mdes017027-RA	1	Reactome: R-HSA-975578	"Reactions specific to the complex N-glycan synthesis pathway"
Mdes004141-RB	10	Reactome: R-HSA-72649;Reactome: R-HSA-382556;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-381042;Reactome: R-HSA-72702;Reactome: R-HSA-9648895;Reactome: R-HSA-72731;Reactome: R-HSA-72695	"Translation initiation complex formation";"ABC-family proteins mediated transport";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"PERK regulates gene expression";"Ribosomal scanning and start codon recognition";"Response of EIF2AK1 (HRI) to heme deficiency";"Recycling of eIF2:GDP";"Formation of the ternary complex, and subsequently, the 43S complex"
Mdes002882-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes009386-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes015025-RA	4	Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-917977	"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Ion channel transport";"Transferrin endocytosis and recycling"
Mdes003692-RA	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Mdes010447-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes000768-RA	16	Reactome: R-HSA-1963642;Reactome: R-HSA-6785631;Reactome: R-HSA-8847993;Reactome: R-HSA-1250342;Reactome: R-HSA-1236394;Reactome: R-HSA-1257604;Reactome: R-HSA-1250196;Reactome: R-HSA-1963640;Reactome: R-HSA-1227986;Reactome: R-HSA-8863795;Reactome: R-HSA-6811558;Reactome: R-HSA-1250347;Reactome: R-HSA-1251985;Reactome: R-HSA-9664565;Reactome: R-HSA-5673001;Reactome: R-HSA-2219530	"PI3K events in ERBB2 signaling";"ERBB2 Regulates Cell Motility";"ERBB2 Activates PTK6 Signaling";"PI3K events in ERBB4 signaling";"Signaling by ERBB4";"PIP3 activates AKT signaling";"SHC1 events in ERBB2 signaling";"GRB2 events in ERBB2 signaling";"Signaling by ERBB2";"Downregulation of ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SHC1 events in ERBB4 signaling";"Nuclear signaling by ERBB4";"Signaling by ERBB2 KD Mutants";"RAF/MAP kinase cascade";"Constitutive Signaling by Aberrant PI3K in Cancer"
Mdes017615-RA	11	MetaCyc: PWY-5938;KEGG: 00650+2.2.1.6;MetaCyc: PWY-5939;KEGG: 00660+2.2.1.6;MetaCyc: PWY-5101;MetaCyc: PWY-6389;MetaCyc: PWY-5103;MetaCyc: PWY-7111;MetaCyc: PWY-5104;KEGG: 00770+2.2.1.6;KEGG: 00290+2.2.1.6	"Pyruvate fermentation to (R)-acetoin I";"Butanoate metabolism";"Pyruvate fermentation to (R)-acetoin II";"C5-Branched dibasic acid metabolism";"L-isoleucine biosynthesis II";"Pyruvate fermentation to (S)-acetoin";"L-isoleucine biosynthesis III";"Pyruvate fermentation to isobutanol (engineered)";"L-isoleucine biosynthesis IV";"Pantothenate and CoA biosynthesis";"Valine, leucine and isoleucine biosynthesis"
Mdes002641-RB	2	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
Mdes004003-RA	8	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Major pathway of rRNA processing in the nucleolus and cytosol";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection"
Mdes017939-RA	5	Reactome: R-HSA-5205685;Reactome: R-HSA-9020702;Reactome: R-HSA-205043;Reactome: R-HSA-209560;Reactome: R-HSA-209543	"Pink/Parkin Mediated Mitophagy";"Interleukin-1 signaling";"NRIF signals cell death from the nucleus";"NF-kB is activated and signals survival";"p75NTR recruits signalling complexes"
Mdes005154-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes019354-RA	8	KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1	"mTOR signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Major pathway of rRNA processing in the nucleolus and cytosol";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection"
Mdes012597-RA	5	MetaCyc: PWY-7849;KEGG: 00230+4.1.1.97;KEGG: 00970+6.1.1.3;MetaCyc: PWY-5691;MetaCyc: PWY-7394	"Urate conversion to allantoin III";"Purine metabolism";"Aminoacyl-tRNA biosynthesis";"Urate conversion to allantoin I";"Urate conversion to allantoin II"
Mdes017641-RA	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Glycerolipid metabolism"
Mdes004466-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Mdes007231-RA	42	Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-606279;Reactome: R-HSA-1221632;Reactome: R-HSA-212300;Reactome: R-HSA-5250924;Reactome: R-HSA-912446;Reactome: R-HSA-2559582;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-977225;Reactome: R-HSA-427413;Reactome: R-HSA-427359;Reactome: R-HSA-5693565;Reactome: R-HSA-110328;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-2299718;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-110330;Reactome: R-HSA-5334118;Reactome: R-HSA-73728;Reactome: R-HSA-5693607;Reactome: R-HSA-8939236;Reactome: R-HSA-5693571;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-3214858;Reactome: R-HSA-8936459;Reactome: R-HSA-5578749;Reactome: R-HSA-3214847;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-2559586;Reactome: R-HSA-73772;Reactome: R-HSA-9610379;Reactome: R-HSA-171306;Reactome: R-HSA-5625886;Reactome: R-HSA-9616222	"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Deposition of new CENPA-containing nucleosomes at the centromere";"Meiotic synapsis";"PRC2 methylates histones and DNA";"B-WICH complex positively regulates rRNA expression";"Meiotic recombination";"Senescence-Associated Secretory Phenotype (SASP)";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"Amyloid fiber formation";"NoRC negatively regulates rRNA expression";"SIRT1 negatively regulates rRNA expression";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Condensation of Prophase Chromosomes";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected purine";"DNA methylation";"RNA Polymerase I Promoter Opening";"Processing of DNA double-strand break ends";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Nonhomologous End-Joining (NHEJ)";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"RMTs methylate histone arginines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional regulation by small RNAs";"HATs acetylate histones";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"DNA Damage/Telomere Stress Induced Senescence";"RNA Polymerase I Promoter Escape";"HCMV Late Events";"Packaging Of Telomere Ends";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Transcriptional regulation of granulopoiesis"
Mdes003407-RA	2	Reactome: R-HSA-975957;Reactome: R-HSA-9010553	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
Mdes006878-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Mdes016353-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes002783-RA	1	Reactome: R-HSA-1855231	"Synthesis of IPs in the ER lumen"
Mdes000877-RB	9	KEGG: 00564+1.1.1.94;MetaCyc: PWY-5667;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;KEGG: 00564+1.1.1.8;MetaCyc: PWY-7902;MetaCyc: PWY-6118;MetaCyc: PWY-7411;MetaCyc: PWY-7385	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism";"Glucosylglycerol biosynthesis";"Glycerol-3-phosphate shuttle";"Phosphatidate biosynthesis (yeast)";"1,3-propanediol biosynthesis (engineered)"
Mdes002183-RB	28	Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-1169408;Reactome: R-HSA-180910;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-159231;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-159230;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-170822;Reactome: R-HSA-4615885;Reactome: R-HSA-8876198	"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"ISG15 antiviral mechanism";"Vpr-mediated nuclear import of PICs";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA replication proteins";"RAB GEFs exchange GTP for GDP on RABs"
Mdes008110-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Mdes002004-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902	"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation"
Mdes016606-RA	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes010197-RA	7	Reactome: R-HSA-5696400;Reactome: R-HSA-5685939;Reactome: R-HSA-5696395;Reactome: R-HSA-110362;Reactome: R-HSA-5696394;Reactome: R-HSA-3108214;Reactome: R-HSA-2173795	"Dual Incision in GG-NER";"HDR through MMEJ (alt-NHEJ)";"Formation of Incision Complex in GG-NER";"POLB-Dependent Long Patch Base Excision Repair";"DNA Damage Recognition in GG-NER";"SUMOylation of DNA damage response and repair proteins";"Downregulation of SMAD2/3:SMAD4 transcriptional activity"
Mdes018397-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes016600-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes012141-RB	10	KEGG: 00332+1.2.1.41+2.7.2.11;KEGG: 00330+1.2.1.41;Reactome: R-HSA-8964539;MetaCyc: PWY-6922;KEGG: 00332+2.7.2.11;KEGG: 00332+2.7.2.11+1.2.1.41;KEGG: 00330+1.2.1.41+2.7.2.11;KEGG: 00330+2.7.2.11;KEGG: 00332+1.2.1.41;KEGG: 00330+2.7.2.11+1.2.1.41	"Carbapenem biosynthesis";"Arginine and proline metabolism";"Glutamate and glutamine metabolism";"L-Ndelta-acetylornithine biosynthesis";"Carbapenem biosynthesis";"Carbapenem biosynthesis";"Arginine and proline metabolism";"Arginine and proline metabolism";"Carbapenem biosynthesis";"Arginine and proline metabolism"
Mdes010041-RA	7	KEGG: 00521+3.1.3.25;KEGG: 00562+3.1.3.25;MetaCyc: PWY-4702;MetaCyc: PWY-6363;MetaCyc: PWY-2301;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25	"Streptomycin biosynthesis";"Inositol phosphate metabolism";"Phytate degradation I";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Myo-inositol biosynthesis";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system"
Mdes020109-RA	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Mdes009339-RA	11	Reactome: R-HSA-418555;Reactome: R-HSA-418597;KEGG: 00230+4.6.1.1;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-170660;Reactome: R-HSA-5610787;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-163615;Reactome: R-HSA-164378	"G alpha (s) signalling events";"G alpha (z) signalling events";"Purine metabolism";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Adenylate cyclase activating pathway";"Hedgehog 'off' state";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"PKA activation";"PKA activation in glucagon signalling"
Mdes017684-RA	6	MetaCyc: PWY-5855;MetaCyc: PWY-5856;MetaCyc: PWY-6708;MetaCyc: PWY-6978;MetaCyc: PWY-5857;KEGG: 00130+4.1.1.98	"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis"
Mdes007444-RA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
Mdes011342-RB	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
Mdes007116-RA	5	Reactome: R-HSA-5610780;Reactome: R-HSA-5610787;Reactome: R-HSA-5610785;Reactome: R-HSA-5610783;Reactome: R-HSA-5632684	"Degradation of GLI1 by the proteasome";"Hedgehog 'off' state";"GLI3 is processed to GLI3R by the proteasome";"Degradation of GLI2 by the proteasome";"Hedgehog 'on' state"
Mdes004711-RA	9	Reactome: R-HSA-110331;Reactome: R-HSA-9608287;Reactome: R-HSA-110330;Reactome: R-HSA-9630222;Reactome: R-HSA-110329;Reactome: R-HSA-110328;Reactome: R-HSA-9608290;Reactome: R-HSA-110357;Reactome: R-HSA-9630221	"Cleavage of the damaged purine";"Defective MUTYH substrate binding";"Recognition and association of DNA glycosylase with site containing an affected purine";"Defective NTHL1 substrate binding";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective MUTYH substrate processing";"Displacement of DNA glycosylase by APEX1";"Defective NTHL1 substrate processing"
Mdes001130-RC	4	Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-975956	"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
Mdes011474-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes004562-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Mdes015918-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes017549-RA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
Mdes007428-RC	3	Reactome: R-HSA-6784531;Reactome: R-HSA-6785470;Reactome: R-HSA-8868766	"tRNA processing in the nucleus";"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion"
Mdes017449-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes007109-RA	4	KEGG: 00970+6.1.1.17;Reactome: R-HSA-379726;MetaCyc: PWY-5188;KEGG: 00860+6.1.1.17	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism"
Mdes000944-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes002142-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Mdes010315-RA	20	Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-5693616;Reactome: R-HSA-110314;Reactome: R-HSA-110320;Reactome: R-HSA-110312;Reactome: R-HSA-69091;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-5656121;Reactome: R-HSA-6804756;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-5651801;Reactome: R-HSA-5685938;Reactome: R-HSA-5696400;Reactome: R-HSA-5655862	"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Presynaptic phase of homologous DNA pairing and strand exchange";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion Synthesis by POLH";"Translesion synthesis by REV1";"Polymerase switching";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by POLI";"Regulation of TP53 Activity through Phosphorylation";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Single Strand Annealing (SSA)";"Dual Incision in GG-NER";"Translesion synthesis by POLK"
Mdes002889-RA	2	Reactome: R-HSA-174403;Reactome: R-HSA-5578999	"Glutathione synthesis and recycling";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)"
Mdes018260-RA	2	KEGG: 00220+2.3.1.35+2.3.1.1;MetaCyc: PWY-5154	"Arginine biosynthesis";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)"
Mdes005543-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes002261-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes010554-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes006488-RA	13	Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339	"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane"
Mdes006133-RA	16	Reactome: R-HSA-179409;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-176412;Reactome: R-HSA-8853884;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174048;Reactome: R-HSA-174154;Reactome: R-HSA-176408;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-174184;Reactome: R-HSA-176407	"APC-Cdc20 mediated degradation of Nek2A";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Phosphorylation of the APC/C";"Transcriptional Regulation by VENTX";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
Mdes016710-RA	21	MetaCyc: PWY-7315;MetaCyc: PWY-6974;MetaCyc: PWY-6973;MetaCyc: PWY-6953;MetaCyc: PWY-6808;MetaCyc: PWY-7104;MetaCyc: PWY-7413;MetaCyc: PWY-7316;KEGG: 00521+4.2.1.46;MetaCyc: PWY-7312;MetaCyc: PWY-7318;MetaCyc: PWY-7814;MetaCyc: PWY-7301;KEGG: 00525+4.2.1.46;MetaCyc: PWY-7688;MetaCyc: PWY-7657;MetaCyc: PWY-6942;MetaCyc: PWY-7414;MetaCyc: PWY-7440;KEGG: 00523+4.2.1.46;MetaCyc: PWY-6976	"Dtdp-n-acetylthomosamine biosynthesis";"Dtdp-l-olivose biosynthesis";"Dtdp-d-olivose, dTDP-D-oliose and dTDP-D-mycarose biosynthesis";"Dtdp-3-acetamido-alpha-d-fucose biosynthesis";"Dtdp-d-forosamine biosynthesis";"Dtdp-l-megosamine biosynthesis";"Dtdp-6-deoxy-alpha-d-allose biosynthesis";"Dtdp-n-acetylviosamine biosynthesis";"Streptomycin biosynthesis";"Dtdp-d-beta-fucofuranose biosynthesis";"Dtdp-3-acetamido-3,6-dideoxy-alpha-d-glucose biosynthesis";"Dtdp-l-daunosamine biosynthesis";"Dtdp-4-o-demethyl-beta-l-noviose biosynthesis";"Acarbose and validamycin biosynthesis";"Dtdp-d-ravidosamine and dTDP-4-acetyl-D-ravidosamine biosynthesis";"Dtdp-beta-l-digitoxose biosynthesis";"Dtdp-d-desosamine biosynthesis";"Dtdp-alpha-d-mycaminose biosynthesis";"Dtdp-beta-l-4-epi-vancosamine biosynthesis";"Polyketide sugar unit biosynthesis";"Dtdp-l-mycarose biosynthesis"
Mdes007836-RA	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
Mdes013985-RC	7	MetaCyc: PWY-5469;MetaCyc: PWY-6824;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-5461;MetaCyc: PWY-7445	"Sesamin biosynthesis";"Justicidin B biosynthesis";"Phenylpropanoid biosynthesis";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Betanidin degradation";"Luteolin triglucuronide degradation"
Mdes013158-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes004608-RA	2	KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7	"Aminobenzoate degradation";"Pyruvate metabolism"
Mdes003156-RA	40	Reactome: R-HSA-72165;Reactome: R-HSA-73779;Reactome: R-HSA-5601884;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-6796648;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-5578749;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-6803529;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-77075;Reactome: R-HSA-167242;Reactome: R-HSA-72163;Reactome: R-HSA-9018519;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167162;Reactome: R-HSA-8851708;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-6807505;Reactome: R-HSA-203927;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-5617472;Reactome: R-HSA-168325;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-72203	"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"PIWI-interacting RNA (piRNA) biogenesis";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Transcriptional regulation by small RNAs";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"FGFR2 alternative splicing";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Major Pathway";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"RNA Polymerase II HIV Promoter Escape";"Signaling by FGFR2 IIIa TM";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"RNA polymerase II transcribes snRNA genes";"MicroRNA (miRNA) biogenesis";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Viral Messenger RNA Synthesis";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Processing of Capped Intron-Containing Pre-mRNA"
Mdes001437-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Mdes009899-RA	32	Reactome: R-HSA-6796648;Reactome: R-HSA-72165;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-6803529;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167162;Reactome: R-HSA-8851708;Reactome: R-HSA-77075;Reactome: R-HSA-167242;Reactome: R-HSA-72163;Reactome: R-HSA-9018519;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-168325;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-72203;Reactome: R-HSA-167158	"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"FGFR2 alternative splicing";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"RNA Polymerase II HIV Promoter Escape";"Signaling by FGFR2 IIIa TM";"RNA Pol II CTD phosphorylation and interaction with CE";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Major Pathway";"Estrogen-dependent gene expression";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Viral Messenger RNA Synthesis";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of the HIV-1 Early Elongation Complex"
Mdes012338-RA	7	Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-1834949;Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061	"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
Mdes016795-RA	3	KEGG: 00790+4.6.1.17;MetaCyc: PWY-6823;Reactome: R-HSA-947581	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
Mdes016406-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes005157-RB	6	Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-72689	"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"Formation of a pool of free 40S subunits"
Mdes002902-RA	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
Mdes015041-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes005644-RA	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
Mdes001107-RA	1	Reactome: R-HSA-203615	"eNOS activation"
Mdes012071-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes018234-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Mdes014737-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes008748-RA	6	Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72706	"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Mdes015434-RA	2	KEGG: 00052+3.2.1.26;KEGG: 00500+3.2.1.26	"Galactose metabolism";"Starch and sucrose metabolism"
Mdes001025-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Mdes003688-RA	3	Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840	"G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle"
Mdes009616-RA	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7656	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
Mdes019463-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes005369-RA	2	Reactome: R-HSA-204174;Reactome: R-HSA-5362517	"Regulation of pyruvate dehydrogenase (PDH) complex";"Signaling by Retinoic Acid"
Mdes006881-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes006483-RA	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
Mdes006879-RA	5	MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-6902	"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)"
Mdes009694-RA	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
Mdes007718-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes007434-RC	6	Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68867	"Unwinding of DNA";"Switching of origins to a post-replicative state";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex"
Mdes003974-RB	4	KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902	"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)"
Mdes009855-RC	2	Reactome: R-HSA-1483152;Reactome: R-HSA-1483115	"Hydrolysis of LPE";"Hydrolysis of LPC"
Mdes004952-RA	13	MetaCyc: PWY-7220;MetaCyc: PWY-7226;KEGG: 00230+1.17.4.1;MetaCyc: PWY-6545;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7210;MetaCyc: PWY-7184;KEGG: 00480+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-7222;MetaCyc: PWY-7227;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1	"Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism"
Mdes004109-RC	3	KEGG: 00534+5.1.3.17;MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
Mdes005831-RA	13	Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764	"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination"
Mdes007680-RA	4	Reactome: R-HSA-8856828;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-3928662	"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling"
Mdes000660-RA	2	Reactome: R-HSA-2151201;Reactome: R-HSA-163282	"Transcriptional activation of mitochondrial biogenesis";"Mitochondrial transcription initiation"
Mdes003923-RA	3	Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-112382	"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex"
Mdes003522-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes004159-RC	5	Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2	"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism"
Mdes012003-RA	2	Reactome: R-HSA-8862803;Reactome: R-HSA-69273	"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Cyclin A/B1/B2 associated events during G2/M transition"
Mdes013745-RA	3	Reactome: R-HSA-5173105;Reactome: R-HSA-5083627;Reactome: R-HSA-2022854	"O-linked glycosylation";"Defective LARGE causes MDDGA6 and MDDGB6";"Keratan sulfate biosynthesis"
Mdes008992-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes004259-RB	13	MetaCyc: PWY-7226;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-7184;KEGG: 00480+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-7227;MetaCyc: PWY-7222;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-6545;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7210	"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides biosynthesis from CTP"
Mdes009730-RA	6	KEGG: 00052+2.7.7.12;MetaCyc: PWY-6317;MetaCyc: PWY-6527;Reactome: R-HSA-5609978;Reactome: R-HSA-70370;KEGG: 00520+2.7.7.12	"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Defective GALT can cause Galactosemia";"Galactose catabolism";"Amino sugar and nucleotide sugar metabolism"
Mdes017530-RA	3	KEGG: 00790+6.3.2.17;MetaCyc: PWY-2161;Reactome: R-HSA-196757	"Folate biosynthesis";"Folate polyglutamylation";"Metabolism of folate and pterines"
Mdes000412-RA	2	Reactome: R-HSA-6782315;MetaCyc: PWY-6829	"tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)"
Mdes014469-RA	5	Reactome: R-HSA-189451;MetaCyc: PWY-5189;KEGG: 00260+2.3.1.37;MetaCyc: PWY-7536;KEGG: 00860+2.3.1.37	"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)";"Glycine, serine and threonine metabolism";"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Porphyrin and chlorophyll metabolism"
Mdes003674-RA	7	MetaCyc: PWY-7294;KEGG: 00630+2.3.3.9;MetaCyc: PWY-7854;MetaCyc: PWY-7295;KEGG: 00620+2.3.3.9;MetaCyc: PWY-6969;MetaCyc: PWY-7118	"D-xylose degradation IV";"Glyoxylate and dicarboxylate metabolism";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"L-arabinose degradation IV";"Pyruvate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Chitin degradation to ethanol"
Mdes004497-RA	6	Reactome: R-HSA-1268020;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980;Reactome: R-HSA-8949613;KEGG: 00195+7.1.2.2;Reactome: R-HSA-163210	"Mitochondrial protein import";"Oxidative phosphorylation";"ATP biosynthesis";"Cristae formation";"Photosynthesis";"Formation of ATP by chemiosmotic coupling"
Mdes010587-RB	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
Mdes004869-RC	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Mdes002661-RB	5	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-6784531;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"tRNA processing in the nucleus";"RNA Polymerase II Transcription Termination"
Mdes007192-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes006504-RB	5	Reactome: R-HSA-2132295;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-983170;Reactome: R-HSA-204005	"MHC class II antigen presentation";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"COPII-mediated vesicle transport"
Mdes016814-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes019221-RA	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
Mdes020082-RA	4	MetaCyc: PWY-7268;KEGG: 00480+1.1.1.49;KEGG: 00030+1.1.1.49;MetaCyc: PWY-8004	"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism";"Pentose phosphate pathway";"Entner-Doudoroff pathway I"
Mdes009184-RA	6	MetaCyc: PWY-4381;MetaCyc: PWY-5744;Reactome: R-HSA-196780;MetaCyc: PWY-5743;MetaCyc: PWY-6722;MetaCyc: PWY-5789	"Fatty acid biosynthesis initiation (bacteria and plants)";"Glyoxylate assimilation";"Biotin transport and metabolism";"3-hydroxypropanoate cycle";"Candicidin biosynthesis";"3-hydroxypropanoate/4-hydroxybutanate cycle"
Mdes008300-RA	5	KEGG: 00280+4.1.3.4;KEGG: 00281+4.1.3.4;KEGG: 00072+4.1.3.4;MetaCyc: PWY-5074;KEGG: 00650+4.1.3.4	"Valine, leucine and isoleucine degradation";"Geraniol degradation";"Synthesis and degradation of ketone bodies";"Mevalonate degradation";"Butanoate metabolism"
Mdes011606-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes019018-RA	4	KEGG: 00405+4.1.3.27;KEGG: 00400+4.1.3.27;MetaCyc: PWY-5958;MetaCyc: PWY-6661	"Phenazine biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Acridone alkaloid biosynthesis";"4-hydroxy-2(1H)-quinolone biosynthesis"
Mdes007132-RA	5	Reactome: R-HSA-5658442;Reactome: R-HSA-186763;Reactome: R-HSA-5218921;Reactome: R-HSA-3928662;Reactome: R-HSA-8849471	"Regulation of RAS by GAPs";"Downstream signal transduction";"VEGFR2 mediated cell proliferation";"EPHB-mediated forward signaling";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"
Mdes003149-RA	13	MetaCyc: PWY-6383;MetaCyc: PWY-7182;MetaCyc: PWY-7736;MetaCyc: PWY-7410;MetaCyc: PWY-7141;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7721;MetaCyc: PWY-6859;MetaCyc: PWY-5123;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7709;MetaCyc: PWY-5122	"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Linalool biosynthesis I";"Stellatic acid biosynthesis";"Ipsdienol biosynthesis";"(3S)-linalool biosynthesis";"Terpenoid backbone biosynthesis";"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"(3R)-linalool biosynthesis";"Geranyl diphosphate biosynthesis"
Mdes000539-RA	13	Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226	"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes016368-RA	3	Reactome: R-HSA-156590;MetaCyc: PWY-1801;KEGG: 00680+3.1.2.12	"Glutathione conjugation";"Formaldehyde oxidation II (glutathione-dependent)";"Methane metabolism"
Mdes008310-RB	4	Reactome: R-HSA-8950505;Reactome: R-HSA-1660499;Reactome: R-HSA-1237112;Reactome: R-HSA-1632852	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Synthesis of PIPs at the plasma membrane";"Methionine salvage pathway";"Macroautophagy"
Mdes007437-RB	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes001242-RA	7	MetaCyc: PWY-7221;Reactome: R-HSA-73817;MetaCyc: PWY-5695;KEGG: 00983+1.1.1.205;MetaCyc: PWY-6596;KEGG: 00230+1.1.1.205;Reactome: R-HSA-6798695	"Guanosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Inosine 5'-phosphate degradation";"Drug metabolism - other enzymes";"Adenosine nucleotides degradation I";"Purine metabolism";"Neutrophil degranulation"
Mdes003523-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes005000-RA	12	KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7416;MetaCyc: PWY-6803;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4	"Ether lipid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism"
Mdes008805-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes017884-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes011484-RC	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes004110-RA	10	MetaCyc: PWY-7328;MetaCyc: PWY-3821;KEGG: 00520+5.1.3.2;MetaCyc: PWY-7344;MetaCyc: PWY-6527;Reactome: R-HSA-70370;Reactome: R-HSA-5609977;MetaCyc: PWY-6397;MetaCyc: PWY-6317;KEGG: 00052+5.1.3.2	"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"D-galactose detoxification";"Amino sugar and nucleotide sugar metabolism";"UDP-alpha-D-galactose biosynthesis";"Stachyose degradation";"Galactose catabolism";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism"
Mdes013884-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes000254-RB	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
Mdes018833-RA	10	Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-3108214;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607	"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"SUMOylation of DNA damage response and repair proteins";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends"
Mdes000251-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-390471	"Major pathway of rRNA processing in the nucleolus and cytosol";"Association of TriC/CCT with target proteins during biosynthesis"
Mdes005375-RA	11	KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-1834949;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693571;Reactome: R-HSA-8866654;KEGG: 05165+2.7.11.1;Reactome: R-HSA-3270619;KEGG: 04150+2.7.11.1	"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Cytosolic sensors of pathogen-associated DNA";"Thermogenesis";"Relaxin signaling pathway";"Nonhomologous End-Joining (NHEJ)";"E3 ubiquitin ligases ubiquitinate target proteins";"Human papillomavirus infection";"IRF3-mediated induction of type I IFN";"mTOR signaling pathway"
Mdes010587-RA	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
Mdes018374-RA	2	KEGG: 00970+6.1.1.11;MetaCyc: PWY-6281	"Aminoacyl-tRNA biosynthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)"
Mdes012626-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Mdes002837-RA	4	Reactome: R-HSA-167160;Reactome: R-HSA-77075;Reactome: R-HSA-72086;MetaCyc: PWY-7375	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping";"Mrna capping I"
Mdes005339-RA	4	Reactome: R-HSA-1614558;MetaCyc: PWY-5331;KEGG: 00430+1.13.11.20;KEGG: 00270+1.13.11.20	"Degradation of cysteine and homocysteine";"Taurine biosynthesis I";"Taurine and hypotaurine metabolism";"Cysteine and methionine metabolism"
Mdes008523-RA	2	Reactome: R-HSA-913709;Reactome: R-HSA-389977	"O-linked glycosylation of mucins";"Post-chaperonin tubulin folding pathway"
Mdes015267-RA	4	KEGG: 00471+5.1.1.3;MetaCyc: PWY-6387;Reactome: R-HSA-3371453;MetaCyc: PWY-6386	"D-Glutamine and D-glutamate metabolism";"UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)";"Regulation of HSF1-mediated heat shock response";"UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"
Mdes015094-RA	11	MetaCyc: PWY-8055;MetaCyc: PWY-8053;KEGG: 00600+3.1.3.4;KEGG: 00561+3.1.3.4;KEGG: 00564+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00565+3.1.3.4;Reactome: R-HSA-2029485;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-8052	"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis II";"Sphingolipid metabolism";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Ether lipid metabolism";"Role of phospholipids in phagocytosis";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"2-arachidonoylglycerol biosynthesis"
Mdes000372-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes015408-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes014151-RA	2	Reactome: R-HSA-8873719;Reactome: R-HSA-6803205	"RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"
Mdes000229-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Mdes005872-RA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Mdes007151-RA	5	MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00561+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22	"Stachyose degradation";"Galactose metabolism";"Glycerolipid metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series"
Mdes000993-RA	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes005259-RA	27	Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-168276;Reactome: R-HSA-3108214;Reactome: R-HSA-159230;Reactome: R-HSA-3371453;Reactome: R-HSA-168333;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-180746;Reactome: R-HSA-5619107	"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP Dependant Mature mRNA";"Regulation of HSF1-mediated heat shock response";"NEP/NS2 Interacts with the Cellular Export Machinery";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"HCMV Late Events";"ISG15 antiviral mechanism";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"
Mdes000895-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes017165-RA	16	Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation"
Mdes000068-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Mdes001693-RA	52	Reactome: R-HSA-203927;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-5617472;Reactome: R-HSA-168325;Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-1834949;Reactome: R-HSA-6781827;Reactome: R-HSA-72203;Reactome: R-HSA-77075;Reactome: R-HSA-5250924;Reactome: R-HSA-167242;Reactome: R-HSA-72163;Reactome: R-HSA-9018519;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167162;Reactome: R-HSA-73780;Reactome: R-HSA-8851708;Reactome: R-HSA-427413;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-76071;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-674695;Reactome: R-HSA-73980;Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-6803529;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-72165;Reactome: R-HSA-5601884;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-76042;Reactome: R-HSA-6796648;Reactome: R-HSA-76066;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-5578749;Reactome: R-HSA-73762;Reactome: R-HSA-112382	"MicroRNA (miRNA) biogenesis";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Viral Messenger RNA Synthesis";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"Cytosolic sensors of pathogen-associated DNA";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Pol II CTD phosphorylation and interaction with CE";"B-WICH complex positively regulates rRNA expression";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Major Pathway";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase III Chain Elongation";"Signaling by FGFR2 IIIa TM";"NoRC negatively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase III Transcription Termination";"Dual incision in TC-NER";"HIV Transcription Initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"FGFR2 alternative splicing";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA Splicing - Minor Pathway";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Transcriptional regulation by small RNAs";"RNA Polymerase I Transcription Initiation";"Formation of RNA Pol II elongation complex"
Mdes002285-RB	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes007750-RA	7	Reactome: R-HSA-166208;Reactome: R-HSA-9639288;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-8943724	"mTORC1-mediated signalling";"Amino acids regulate mTORC1";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"TP53 Regulates Metabolic Genes";"Macroautophagy";"Regulation of PTEN gene transcription"
Mdes003346-RA	2	Reactome: R-HSA-181429;Reactome: R-HSA-212676	"Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle"
Mdes012865-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes005546-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes003727-RA	1	Reactome: R-HSA-191273	"Cholesterol biosynthesis"
Mdes008752-RB	9	Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-6807505;Reactome: R-HSA-2173796;Reactome: R-HSA-112382;Reactome: R-HSA-167290	"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA polymerase II transcribes snRNA genes";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation"
Mdes018296-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Mdes008753-RB	7	Reactome: R-HSA-8876198;Reactome: R-HSA-381183;Reactome: R-HSA-380994;Reactome: R-HSA-204005;Reactome: R-HSA-9614657;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168	"RAB GEFs exchange GTP for GDP on RABs";"ATF6 (ATF6-alpha) activates chaperone genes";"ATF4 activates genes in response to endoplasmic reticulum stress";"COPII-mediated vesicle transport";"FOXO-mediated transcription of cell death genes";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)"
Mdes009987-RB	13	Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764	"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination"
Mdes009753-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes002678-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes007414-RF	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes007804-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes011006-RA	2	Reactome: R-HSA-1912399;KEGG: 00514+2.4.1.221	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Other types of O-glycan biosynthesis"
Mdes001079-RA	27	Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-3108214;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377	"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA damage response and repair proteins";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"HCMV Late Events";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins"
Mdes001128-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes003038-RA	5	MetaCyc: PWY-5667;KEGG: 00564+2.7.7.41;MetaCyc: PWY-5981;KEGG: 04070+2.7.7.41;MetaCyc: PWY-7817	"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)"
Mdes003483-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes003625-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes005660-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Mdes012026-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes006238-RA	7	MetaCyc: PWY-7158;KEGG: 00400+1.14.16.1;KEGG: 00790+1.14.16.1;Reactome: R-HSA-8964208;KEGG: 00360+1.14.16.1;Reactome: R-HSA-2160456;MetaCyc: PWY-6134	"L-phenylalanine degradation V";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Folate biosynthesis";"Phenylalanine metabolism";"Phenylalanine metabolism";"Phenylketonuria";"L-tyrosine biosynthesis IV"
Mdes004935-RB	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Mdes000322-RB	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes009693-RA	15	Reactome: R-HSA-9029569;Reactome: R-HSA-2559585;Reactome: R-HSA-2559580;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-8936459;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oncogene Induced Senescence";"Oxidative Stress Induced Senescence";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation"
Mdes006386-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes018091-RA	7	Reactome: R-HSA-8953750;Reactome: R-HSA-3214841;Reactome: R-HSA-212300;Reactome: R-HSA-2559580;Reactome: R-HSA-8943724;Reactome: R-HSA-5617472;Reactome: R-HSA-9609690	"Transcriptional Regulation by E2F6";"PKMTs methylate histone lysines";"PRC2 methylates histones and DNA";"Oxidative Stress Induced Senescence";"Regulation of PTEN gene transcription";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HCMV Early Events"
Mdes006442-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Mdes005901-RA	12	KEGG: 00130+2.1.1.222+2.1.1.64;Reactome: R-HSA-2142789;MetaCyc: PWY-5855;MetaCyc: PWY-5857;MetaCyc: PWY-6708;MetaCyc: PWY-5871;MetaCyc: PWY-5873;MetaCyc: PWY-5856;MetaCyc: PWY-5870;MetaCyc: PWY-5872;MetaCyc: PWY-7233;MetaCyc: PWY-7230	"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)"
Mdes017079-RA	5	Reactome: R-HSA-9033500;KEGG: 00565+2.5.1.26;Reactome: R-HSA-9033241;MetaCyc: PWY-7782;Reactome: R-HSA-75896	"TYSND1 cleaves peroxisomal proteins";"Ether lipid metabolism";"Peroxisomal protein import";"Plasmalogen biosynthesis";"Plasmalogen biosynthesis"
Mdes019191-RA	6	KEGG: 00290+4.2.1.9;MetaCyc: PWY-7111;MetaCyc: PWY-5103;MetaCyc: PWY-5101;KEGG: 00770+4.2.1.9;MetaCyc: PWY-5104	"Valine, leucine and isoleucine biosynthesis";"Pyruvate fermentation to isobutanol (engineered)";"L-isoleucine biosynthesis III";"L-isoleucine biosynthesis II";"Pantothenate and CoA biosynthesis";"L-isoleucine biosynthesis IV"
Mdes012988-RA	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
Mdes001226-RA	14	MetaCyc: PWY-6598;MetaCyc: PWY-7724;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199;MetaCyc: PWY-8041;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-7725	"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis V (8-detaturase, mammals)"
Mdes001548-RA	5	Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-427389;Reactome: R-HSA-6804758;Reactome: R-HSA-73762	"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation";"RNA Polymerase I Transcription Initiation"
Mdes019284-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes016135-RA	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
Mdes010237-RB	13	Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764	"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination"
Mdes001861-RA	18	MetaCyc: PWY-7383;MetaCyc: PWY-7117;KEGG: 00960+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00360+2.6.1.1;KEGG: 00270+2.6.1.1;MetaCyc: PWY-6642;KEGG: 00710+2.6.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-6638;KEGG: 00220+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00401+2.6.1.1;MetaCyc: PWY-5913;KEGG: 00950+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00400+2.6.1.1	"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Coenzyme M biosynthesis II";"Phenylalanine metabolism";"Cysteine and methionine metabolism";"(R)-cysteate degradation";"Carbon fixation in photosynthetic organisms";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Sulfolactate degradation III";"Arginine biosynthesis";"Alanine, aspartate and glutamate metabolism";"Tyrosine metabolism";"Novobiocin biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Isoquinoline alkaloid biosynthesis";"Arginine and proline metabolism";"Phenylalanine, tyrosine and tryptophan biosynthesis"
Mdes005521-RB	3	Reactome: R-HSA-6804760;Reactome: R-HSA-3214858;Reactome: R-HSA-191859	"Regulation of TP53 Activity through Methylation";"RMTs methylate histone arginines";"snRNP Assembly"
Mdes002519-RA	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
Mdes009275-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes019965-RA	4	KEGG: 00270+2.5.1.6;MetaCyc: PWY-5912;MetaCyc: PWY-5041;Reactome: R-HSA-156581	"Cysteine and methionine metabolism";"2'-deoxymugineic acid phytosiderophore biosynthesis";"S-adenosyl-L-methionine cycle II";"Methylation"
Mdes010468-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Mdes002174-RA	8	Reactome: R-HSA-6790901;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-6791226;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025	"rRNA modification in the nucleus and cytosol";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Major pathway of rRNA processing in the nucleolus and cytosol";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation"
Mdes004136-RB	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Mdes003786-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes010775-RC	29	Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167162;Reactome: R-HSA-77075;Reactome: R-HSA-73779;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-73762;Reactome: R-HSA-112382;Reactome: R-HSA-427413;Reactome: R-HSA-5696400;Reactome: R-HSA-5696395;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-6781827	"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation";"Formation of RNA Pol II elongation complex";"NoRC negatively regulates rRNA expression";"Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Dual incision in TC-NER";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
Mdes019171-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes011131-RA	18	Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925;MetaCyc: PWY-7417;Reactome: R-HSA-1482922;MetaCyc: PWY-8053;MetaCyc: PWY-8051;MetaCyc: PWY-7409;MetaCyc: PWY-6803;Reactome: R-HSA-1482801;MetaCyc: PWY-7416;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482839;KEGG: 00565+3.1.1.4	"Synthesis of PA";"Glycerophospholipid metabolism";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PI";"Anandamide biosynthesis II";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Linoleic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Acyl chain remodelling of PE";"Ether lipid metabolism"
Mdes019614-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes000469-RB	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes013320-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes001573-RB	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes010541-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes016970-RA	6	MetaCyc: PWY-2;KEGG: 00310+1.2.1.19;MetaCyc: PWY-3;KEGG: 00330+1.2.1.19;MetaCyc: PWY-6328;KEGG: 00410+1.2.1.19	"Putrescine degradation IV";"Lysine degradation";"Putrescine degradation V";"Arginine and proline metabolism";"L-lysine degradation X";"beta-Alanine metabolism"
Mdes005826-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes008260-RA	1	Reactome: R-HSA-375276	"Peptide ligand-binding receptors"
Mdes013410-RA	57	Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5668541;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-174154;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-6798695;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276	"Neddylation";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"TNFR2 non-canonical NF-kB pathway";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"APC/C:Cdc20 mediated degradation of Securin";"Ub-specific processing proteases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neutrophil degranulation";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint"
Mdes016074-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes000303-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes009238-RB	15	Reactome: R-HSA-203927;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-426486;Reactome: R-HSA-4086398;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-194840;Reactome: R-HSA-9022692	"MicroRNA (miRNA) biogenesis";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"Small interfering RNA (siRNA) biogenesis";"Ca2+ pathway";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Rho GTPase cycle";"Regulation of MECP2 expression and activity"
Mdes005544-RA	5	Reactome: R-HSA-5693565;Reactome: R-HSA-5693607;Reactome: R-HSA-3232118;Reactome: R-HSA-5693571;Reactome: R-HSA-69473	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Processing of DNA double-strand break ends";"SUMOylation of transcription factors";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint"
Mdes008921-RB	1	Reactome: R-HSA-901032	"ER Quality Control Compartment (ERQC)"
Mdes000777-RA	10	Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-167161;Reactome: R-HSA-73779;Reactome: R-HSA-9018519;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-6807505	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"HIV Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA polymerase II transcribes snRNA genes"
Mdes003792-RB	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
Mdes018963-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes018531-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-3299685	"TP53 Regulates Metabolic Genes";"Detoxification of Reactive Oxygen Species"
Mdes010165-RA	1	Reactome: R-HSA-975578	"Reactions specific to the complex N-glycan synthesis pathway"
Mdes017197-RA	6	Reactome: R-HSA-1268020;MetaCyc: PWY-4984;KEGG: 00220+2.1.3.3;MetaCyc: PWY-7400;Reactome: R-HSA-70635;MetaCyc: PWY-4981	"Mitochondrial protein import";"Urea cycle";"Arginine biosynthesis";"L-arginine biosynthesis IV (archaebacteria)";"Urea cycle";"L-proline biosynthesis II (from arginine)"
Mdes007490-RB	2	Reactome: R-HSA-445095;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport"
Mdes011774-RB	1	KEGG: 00240+3.1.3.89	"Pyrimidine metabolism"
Mdes006632-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes001050-RB	83	Reactome: R-HSA-5654727;Reactome: R-HSA-8875656;Reactome: R-HSA-5654704;Reactome: R-HSA-5654706;Reactome: R-HSA-512988;Reactome: R-HSA-983695;Reactome: R-HSA-1433559;Reactome: R-HSA-179812;Reactome: R-HSA-354194;Reactome: R-HSA-9645135;Reactome: R-HSA-912631;Reactome: R-HSA-9034864;Reactome: R-HSA-5654689;Reactome: R-HSA-9607240;Reactome: R-HSA-2871796;Reactome: R-HSA-2424491;Reactome: R-HSA-167044;Reactome: R-HSA-8851907;Reactome: R-HSA-8865999;Reactome: R-HSA-5654693;Reactome: R-HSA-5654700;Reactome: R-HSA-5654733;Reactome: R-HSA-1236382;Reactome: R-HSA-8853659;Reactome: R-HSA-180336;Reactome: R-HSA-5655291;Reactome: R-HSA-5637810;Reactome: R-HSA-5654699;Reactome: R-HSA-112412;Reactome: R-HSA-8983432;Reactome: R-HSA-6807004;Reactome: R-HSA-9027284;Reactome: R-HSA-210993;Reactome: R-HSA-8851805;Reactome: R-HSA-2871809;Reactome: R-HSA-186763;Reactome: R-HSA-8875555;Reactome: R-HSA-2179392;Reactome: R-HSA-109704;Reactome: R-HSA-180292;Reactome: R-HSA-1433557;Reactome: R-HSA-8875360;Reactome: R-HSA-9634285;Reactome: R-HSA-9028731;Reactome: R-HSA-8856825;Reactome: R-HSA-1295596;Reactome: R-HSA-8856828;Reactome: R-HSA-389359;Reactome: R-HSA-9026519;Reactome: R-HSA-1250347;Reactome: R-HSA-5654726;Reactome: R-HSA-9664565;Reactome: R-HSA-5673001;Reactome: R-HSA-2029482;Reactome: R-HSA-5654732;Reactome: R-HSA-5654710;Reactome: R-HSA-5654712;Reactome: R-HSA-6811558;Reactome: R-HSA-5654688;Reactome: R-HSA-1839117;Reactome: R-HSA-5655302;Reactome: R-HSA-2428933;Reactome: R-HSA-182971;Reactome: R-HSA-1257604;Reactome: R-HSA-9028335;Reactome: R-HSA-1250196;Reactome: R-HSA-1963640;Reactome: R-HSA-74749;Reactome: R-HSA-8853338;Reactome: R-HSA-1963642;Reactome: R-HSA-5654719;Reactome: R-HSA-912526;Reactome: R-HSA-388841;Reactome: R-HSA-8853334;Reactome: R-HSA-2219530;Reactome: R-HSA-2730905;Reactome: R-HSA-5663213;Reactome: R-HSA-5654695;Reactome: R-HSA-5655253;Reactome: R-HSA-375165;Reactome: R-HSA-74751;Reactome: R-HSA-391160;Reactome: R-HSA-5654720	"Negative regulation of FGFR2 signaling";"MET receptor recycling";"SHC-mediated cascade:FGFR3";"FRS-mediated FGFR3 signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Regulation of KIT signaling";"GRB2 events in EGFR signaling";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"STAT5 Activation";"Regulation of signaling by CBL";"Activated NTRK3 signals through RAS";"PI-3K cascade:FGFR1";"FLT3 Signaling";"FCERI mediated MAPK activation";"DAP12 signaling";"Signalling to RAS";"MET activates PI3K/AKT signaling";"MET activates PTPN11";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR2 signaling";"Negative regulation of FGFR4 signaling";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"RET signaling";"SHC1 events in EGFR signaling";"Signaling by FGFR4 in disease";"Constitutive Signaling by EGFRvIII";"SHC-mediated cascade:FGFR2";"SOS-mediated signalling";"Interleukin-15 signaling";"Negative regulation of MET activity";"Erythropoietin activates RAS";"Tie2 Signaling";"MET activates RAS signaling";"FCERI mediated Ca+2 mobilization";"Downstream signal transduction";"MET activates RAP1 and RAC1";"EGFR Transactivation by Gastrin";"PI3K Cascade";"GAB1 signalosome";"Signaling by SCF-KIT";"InlB-mediated entry of Listeria monocytogenes into host cell";"Constitutive Signaling by Overexpressed ERBB2";"Activated NTRK2 signals through FRS2 and FRS3";"Cargo recognition for clathrin-mediated endocytosis";"Spry regulation of FGF signaling";"Clathrin-mediated endocytosis";"CD28 dependent Vav1 pathway";"Activated NTRK2 signals through RAS";"SHC1 events in ERBB4 signaling";"Negative regulation of FGFR1 signaling";"Signaling by ERBB2 KD Mutants";"RAF/MAP kinase cascade";"Regulation of actin dynamics for phagocytic cup formation";"Negative regulation of FGFR3 signaling";"PI-3K cascade:FGFR3";"FRS-mediated FGFR4 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SHC-mediated cascade:FGFR1";"Signaling by cytosolic FGFR1 fusion mutants";"Signaling by FGFR1 in disease";"SHC-related events triggered by IGF1R";"EGFR downregulation";"PIP3 activates AKT signaling";"Activated NTRK2 signals through PI3K";"SHC1 events in ERBB2 signaling";"GRB2 events in ERBB2 signaling";"Signal attenuation";"Signaling by FGFR3 point mutants in cancer";"PI3K events in ERBB2 signaling";"SHC-mediated cascade:FGFR4";"Interleukin receptor SHC signaling";"Costimulation by the CD28 family";"Signaling by FGFR3 fusions in cancer";"Constitutive Signaling by Aberrant PI3K in Cancer";"Role of LAT2/NTAL/LAB on calcium mobilization";"RHO GTPases Activate WASPs and WAVEs";"PI-3K cascade:FGFR2";"Signaling by FGFR2 in disease";"NCAM signaling for neurite out-growth";"Insulin receptor signalling cascade";"Signal regulatory protein family interactions";"PI-3K cascade:FGFR4"
Mdes018673-RA	2	Reactome: R-HSA-1483148;Reactome: R-HSA-1483166	"Synthesis of PG";"Synthesis of PA"
Mdes007662-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes005394-RA	2	KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10	"Glycine, serine and threonine metabolism";"One carbon pool by folate"
Mdes000023-RA	14	MetaCyc: PWY-7279;KEGG: 00720+1.3.5.1;MetaCyc: PWY-5690;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-7254;KEGG: 00020+1.3.5.1;KEGG: 00650+1.3.5.1;KEGG: 00190+1.3.5.1;MetaCyc: PWY-3781;Reactome: R-HSA-611105;MetaCyc: PWY-6969;MetaCyc: PWY-561;MetaCyc: PWY-4302	"Aerobic respiration II (cytochrome c) (yeast)";"Carbon fixation pathways in prokaryotes";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Citrate cycle (TCA cycle)";"Butanoate metabolism";"Oxidative phosphorylation";"Aerobic respiration I (cytochrome c)";"Respiratory electron transport";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration III (alternative oxidase pathway)"
Mdes006124-RA	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes000140-RA	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
Mdes004007-RA	5	MetaCyc: PWY-5531;KEGG: 00860+4.1.1.37;MetaCyc: PWY-7159;Reactome: R-HSA-189451;MetaCyc: PWY-7766	"3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis";"Heme b biosynthesis IV (Gram-positive bacteria)"
Mdes016033-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes012493-RA	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
Mdes004075-RA	4	Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-1912420	"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Pre-NOTCH Processing in Golgi"
Mdes012953-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes007513-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression"
Mdes003792-RA	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
Mdes006197-RA	10	Reactome: R-HSA-5693568;Reactome: R-HSA-3108214;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756	"Resolution of D-loop Structures through Holliday Junction Intermediates";"SUMOylation of DNA damage response and repair proteins";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation"
Mdes000098-RA	3	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
Mdes017504-RA	3	MetaCyc: PWY-5067;KEGG: 00500+2.4.1.11;Reactome: R-HSA-3322077	"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Glycogen synthesis"
Mdes001685-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes000237-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Mdes006265-RA	5	MetaCyc: PWY-7282;Reactome: R-HSA-6798695;KEGG: 00750+2.7.1.35;Reactome: R-HSA-964975;MetaCyc: PWY-7204	"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Neutrophil degranulation";"Vitamin B6 metabolism";"Vitamins B6 activation to pyridoxal phosphate";"Pyridoxal 5'-phosphate salvage II (plants)"
Mdes014677-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes013163-RA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
Mdes004548-RA	4	MetaCyc: PWY-6963;KEGG: 00250+1.4.1.14;KEGG: 00910+1.4.1.14;Reactome: R-HSA-73621	"Ammonia assimilation cycle I";"Alanine, aspartate and glutamate metabolism";"Nitrogen metabolism";"Pyrimidine catabolism"
Mdes018383-RA	13	Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-975957	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes012214-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Mdes006427-RA	1	Reactome: R-HSA-5676934	"Protein repair"
Mdes014515-RA	4	Reactome: R-HSA-382556;Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895	"ABC-family proteins mediated transport";"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis"
Mdes018171-RA	4	Reactome: R-HSA-73817;MetaCyc: PWY-7234;MetaCyc: PWY-6123;KEGG: 00230+5.4.99.18	"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism"
Mdes017273-RA	2	MetaCyc: PWY-7799;MetaCyc: PWY-7800	"Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway"
Mdes006418-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes015657-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Mdes010085-RA	11	Reactome: R-HSA-212436;Reactome: R-HSA-400253;Reactome: R-HSA-2426168;Reactome: R-HSA-1368108;Reactome: R-HSA-383280;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-2151201;Reactome: R-HSA-400206;Reactome: R-HSA-381340;Reactome: R-HSA-1368082	"Generic Transcription Pathway";"Circadian Clock";"Activation of gene expression by SREBF (SREBP)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nuclear Receptor transcription pathway";"Estrogen-dependent gene expression";"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"Regulation of lipid metabolism by PPARalpha";"Transcriptional regulation of white adipocyte differentiation";"RORA activates gene expression"
Mdes018569-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes006554-RB	9	Reactome: R-HSA-6781827;Reactome: R-HSA-5696395;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-5696400;Reactome: R-HSA-5696394;Reactome: R-HSA-110314;Reactome: R-HSA-6782135;Reactome: R-HSA-8951664	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of Incision Complex in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER";"DNA Damage Recognition in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Dual incision in TC-NER";"Neddylation"
Mdes009645-RA	14	Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-2173788;Reactome: R-HSA-450520;Reactome: R-HSA-9648025;Reactome: R-HSA-9634638;Reactome: R-HSA-165054;Reactome: R-HSA-141444;Reactome: R-HSA-5687128;Reactome: R-HSA-168333;Reactome: R-HSA-3769402;Reactome: R-HSA-69273;Reactome: R-HSA-5663220	"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Downregulation of TGF-beta receptor signaling";"HuR (ELAVL1) binds and stabilizes mRNA";"EML4 and NUDC in mitotic spindle formation";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Rev-mediated nuclear export of HIV RNA";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"MAPK6/MAPK4 signaling";"NEP/NS2 Interacts with the Cellular Export Machinery";"Deactivation of the beta-catenin transactivating complex";"Cyclin A/B1/B2 associated events during G2/M transition";"RHO GTPases Activate Formins"
Mdes018717-RA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
Mdes006605-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Mdes004164-RA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes006156-RA	11	Reactome: R-HSA-163359;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;Reactome: R-HSA-170660;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418597;Reactome: R-HSA-163615;Reactome: R-HSA-164378	"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"Adenylate cyclase activating pathway";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (s) signalling events";"Purine metabolism";"G alpha (z) signalling events";"PKA activation";"PKA activation in glucagon signalling"
Mdes003751-RA	5	Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-1222556	"Amino acids regulate mTORC1";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Ion channel transport";"ROS and RNS production in phagocytes"
Mdes007734-RA	2	Reactome: R-HSA-163282;Reactome: R-HSA-2151201	"Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis"
Mdes009366-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Mdes008609-RA	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
Mdes001851-RC	4	Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex"
Mdes012965-RA	14	KEGG: 00591+3.1.1.4;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-7416;MetaCyc: PWY-7417;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4+3.1.1.5;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;Reactome: R-HSA-975634	"Linoleic acid metabolism";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Ether lipid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Retinoid metabolism and transport"
Mdes008799-RA	13	Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes003799-RB	3	Reactome: R-HSA-947581;KEGG: 00790+2.10.1.1;MetaCyc: PWY-6823	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
Mdes019085-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Mdes006625-RA	5	Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"ROS and RNS production in phagocytes";"Ion channel transport";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Amino acids regulate mTORC1"
Mdes003546-RA	3	Reactome: R-HSA-74217;MetaCyc: PWY-6596;KEGG: 00230+3.5.4.6	"Purine salvage";"Adenosine nucleotides degradation I";"Purine metabolism"
Mdes012877-RA	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
Mdes009974-RA	3	Reactome: R-HSA-909733;Reactome: R-HSA-8983711;Reactome: R-HSA-877300	"Interferon alpha/beta signaling";"OAS antiviral response";"Interferon gamma signaling"
Mdes007644-RA	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
Mdes009680-RC	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
Mdes014367-RA	11	Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-5610787;Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-418594;Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418597;Reactome: R-HSA-163615;Reactome: R-HSA-164378	"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"Hedgehog 'off' state";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"G alpha (i) signalling events";"G alpha (s) signalling events";"Purine metabolism";"G alpha (z) signalling events";"PKA activation";"PKA activation in glucagon signalling"
Mdes012848-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes005187-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes011551-RB	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis"
Mdes011614-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes004685-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes000610-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Mdes003277-RA	4	Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
Mdes007753-RA	3	KEGG: 00970+6.1.1.5;Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Mdes006906-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes006503-RB	10	Reactome: R-HSA-201722;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5689880;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3214847;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Formation of the beta-catenin:TCF transactivating complex";"Human papillomavirus infection";"Ub-specific processing proteases";"mTOR signaling pathway";"HATs acetylate histones";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway"
Mdes001209-RB	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Mdes008812-RA	8	MetaCyc: PWY-7181;KEGG: 00983+3.5.4.5;MetaCyc: PWY-6556;Reactome: R-HSA-73614;MetaCyc: PWY-7193;Reactome: R-HSA-6798695;KEGG: 00240+3.5.4.5;MetaCyc: PWY-7199	"Pyrimidine deoxyribonucleosides degradation";"Drug metabolism - other enzymes";"Pyrimidine ribonucleosides salvage II";"Pyrimidine salvage";"Pyrimidine ribonucleosides salvage I";"Neutrophil degranulation";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleosides salvage"
Mdes009156-RE	3	Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes006098-RA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
Mdes018163-RA	3	Reactome: R-HSA-909733;KEGG: 00480+3.4.11.1;Reactome: R-HSA-877300	"Interferon alpha/beta signaling";"Glutathione metabolism";"Interferon gamma signaling"
Mdes004217-RA	2	Reactome: R-HSA-5250971;Reactome: R-HSA-5682910	"Toxicity of botulinum toxin type C (BoNT/C)";"LGI-ADAM interactions"
Mdes010578-RA	52	Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-1834949;Reactome: R-HSA-6781827;Reactome: R-HSA-72203;Reactome: R-HSA-72086;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-203927;Reactome: R-HSA-5617472;Reactome: R-HSA-168325;Reactome: R-HSA-167246;Reactome: R-HSA-427413;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167238;Reactome: R-HSA-76071;Reactome: R-HSA-167243;Reactome: R-HSA-5250924;Reactome: R-HSA-167242;Reactome: R-HSA-77075;Reactome: R-HSA-9018519;Reactome: R-HSA-72163;Reactome: R-HSA-75955;Reactome: R-HSA-8851708;Reactome: R-HSA-73780;Reactome: R-HSA-167162;Reactome: R-HSA-167287;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-6803529;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-674695;Reactome: R-HSA-73980;Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-113418;Reactome: R-HSA-76066;Reactome: R-HSA-167290;Reactome: R-HSA-73762;Reactome: R-HSA-5578749;Reactome: R-HSA-112382;Reactome: R-HSA-5601884;Reactome: R-HSA-73779;Reactome: R-HSA-72165;Reactome: R-HSA-76042;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-6796648	"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Cytosolic sensors of pathogen-associated DNA";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Processing of Capped Intron-Containing Pre-mRNA";"mRNA Capping";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"MicroRNA (miRNA) biogenesis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Viral Messenger RNA Synthesis";"Tat-mediated elongation of the HIV-1 transcript";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Tat-mediated HIV elongation arrest and recovery";"B-WICH complex positively regulates rRNA expression";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"Estrogen-dependent gene expression";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Elongation";"Signaling by FGFR2 IIIa TM";"RNA Polymerase III Chain Elongation";"RNA Polymerase II HIV Promoter Escape";"HIV elongation arrest and recovery";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"FGFR2 alternative splicing";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase III Transcription Termination";"Dual incision in TC-NER";"HIV Transcription Initiation";"Formation of the Early Elongation Complex";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Pausing and recovery of HIV elongation";"RNA Polymerase I Transcription Initiation";"Transcriptional regulation by small RNAs";"Formation of RNA Pol II elongation complex";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"TP53 Regulates Transcription of DNA Repair Genes"
Mdes009617-RA	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
Mdes000920-RB	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes006142-RA	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
Mdes010310-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes008515-RA	2	Reactome: R-HSA-382556;Reactome: R-HSA-5678895	"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis"
Mdes003266-RB	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes007557-RA	2	Reactome: R-HSA-428890;KEGG: 04660+2.7.10.2	"Role of ABL in ROBO-SLIT signaling";"T cell receptor signaling pathway"
Mdes004490-RA	2	Reactome: R-HSA-5663220;Reactome: R-HSA-376176	"RHO GTPases Activate Formins";"Signaling by ROBO receptors"
Mdes009208-RA	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
Mdes009408-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Mdes018066-RA	6	Reactome: R-HSA-450385;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-6791226;Reactome: R-HSA-450604	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA"
Mdes004537-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes014633-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-171319	"HATs acetylate histones";"Telomere Extension By Telomerase"
Mdes000049-RA	7	Reactome: R-HSA-73817;KEGG: 00230+4.3.2.2;MetaCyc: PWY-7219;MetaCyc: PWY-6123;MetaCyc: PWY-7234;MetaCyc: PWY-6124;KEGG: 00250+4.3.2.2	"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis II";"Alanine, aspartate and glutamate metabolism"
Mdes000519-RC	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes010740-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes018118-RA	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
Mdes004947-RA	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
Mdes005485-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes018450-RA	1	Reactome: R-HSA-77108	"Utilization of Ketone Bodies"
Mdes007965-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes009931-RA	11	Reactome: R-HSA-418594;Reactome: R-HSA-170660;Reactome: R-HSA-432040;Reactome: R-HSA-418555;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418597;Reactome: R-HSA-163359;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-164378	"G alpha (i) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (s) signalling events";"Purine metabolism";"G alpha (z) signalling events";"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"PKA activation";"PKA activation in glucagon signalling"
Mdes014659-RA	1	Reactome: R-HSA-4419969	"Depolymerisation of the Nuclear Lamina"
Mdes000787-RB	64	Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-1834949;Reactome: R-HSA-5362768;Reactome: R-HSA-73780;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-4608870;Reactome: R-HSA-73980;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-2467813;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-5610783;Reactome: R-HSA-68949;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-76066;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-4641257;Reactome: R-HSA-180585;Reactome: R-HSA-5668541;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-532668;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-76071;Reactome: R-HSA-174178;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-69481;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-9604323;Reactome: R-HSA-8852276	"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Neddylation";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Cytosolic sensors of pathogen-associated DNA";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"RNA Polymerase III Chain Elongation";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"Asymmetric localization of PCP proteins";"RNA Polymerase III Transcription Termination";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"Separation of Sister Chromatids";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"Degradation of GLI2 by the proteasome";"Orc1 removal from chromatin";"Hedgehog 'on' state";"Ub-specific processing proteases";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"Degradation of AXIN";"Vif-mediated degradation of APOBEC3G";"TNFR2 non-canonical NF-kB pathway";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"G2/M Checkpoints";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Negative regulation of NOTCH4 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint"
Mdes009335-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Mdes014330-RA	13	MetaCyc: PWY-6383;MetaCyc: PWY-7182;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7721;MetaCyc: PWY-6859;MetaCyc: PWY-5123;MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-7709;MetaCyc: PWY-5122	"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Linalool biosynthesis I";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis";"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"(3R)-linalool biosynthesis";"Geranyl diphosphate biosynthesis"
Mdes016767-RA	5	MetaCyc: PWY-7082;KEGG: 00190+7.1.1.8;MetaCyc: PWY-6692;MetaCyc: PWY-7279;MetaCyc: PWY-3781	"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Oxidative phosphorylation";"Fe(II) oxidation";"Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration I (cytochrome c)"
Mdes000639-RB	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Mdes015302-RA	10	Reactome: R-HSA-5689880;Reactome: R-HSA-432720;Reactome: R-HSA-8875360;Reactome: R-HSA-917729;Reactome: R-HSA-9635644;Reactome: R-HSA-8856828;Reactome: R-HSA-9636383;Reactome: R-HSA-8856825;Reactome: R-HSA-6807004;Reactome: R-HSA-182971	"Ub-specific processing proteases";"Lysosome Vesicle Biogenesis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Inhibition of membrane repair";"Clathrin-mediated endocytosis";"Prevention of phagosomal-lysosomal fusion";"Cargo recognition for clathrin-mediated endocytosis";"Negative regulation of MET activity";"EGFR downregulation"
Mdes010595-RA	4	MetaCyc: PWY-5041;Reactome: R-HSA-156581;MetaCyc: PWY-5912;KEGG: 00270+2.5.1.6	"S-adenosyl-L-methionine cycle II";"Methylation";"2'-deoxymugineic acid phytosiderophore biosynthesis";"Cysteine and methionine metabolism"
Mdes012592-RA	2	KEGG: 00500+2.4.1.15;Reactome: R-HSA-446205	"Starch and sucrose metabolism";"Synthesis of GDP-mannose"
Mdes013757-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Mdes003029-RA	4	Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48;KEGG: 00983+2.7.1.48;MetaCyc: PWY-7193	"Pyrimidine salvage";"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Pyrimidine ribonucleosides salvage I"
Mdes009041-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340	"PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation"
Mdes004371-RA	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
Mdes017652-RA	17	Reactome: R-HSA-1834949;Reactome: R-HSA-2559586;Reactome: R-HSA-5685939;Reactome: R-HSA-5693554;Reactome: R-HSA-5693565;Reactome: R-HSA-5693616;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693548;Reactome: R-HSA-5685938;Reactome: R-HSA-3270619;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693579	"Cytosolic sensors of pathogen-associated DNA";"DNA Damage/Telomere Stress Induced Senescence";"HDR through MMEJ (alt-NHEJ)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Sensing of DNA Double Strand Breaks";"HDR through Single Strand Annealing (SSA)";"IRF3-mediated induction of type I IFN";"Processing of DNA double-strand break ends";"Meiotic recombination";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange"
Mdes008565-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-532668	"Neutrophil degranulation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
Mdes019385-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Mdes015609-RA	4	KEGG: 00520+2.7.1.59;Reactome: R-HSA-446210;MetaCyc: PWY-6906;MetaCyc: PWY-6517	"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"Chitin derivatives degradation";"N-acetylglucosamine degradation II"
Mdes002798-RA	17	Reactome: R-HSA-6804756;KEGG: 05165+2.7.11.1;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;KEGG: 04150+2.7.11.1;Reactome: R-HSA-4615885;Reactome: R-HSA-9022692;Reactome: R-HSA-174178;Reactome: R-HSA-5663220;KEGG: 04926+2.7.11.1;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-141444;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"Regulation of TP53 Activity through Phosphorylation";"Human papillomavirus infection";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"mTOR signaling pathway";"SUMOylation of DNA replication proteins";"Regulation of MECP2 expression and activity";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"RHO GTPases Activate Formins";"Relaxin signaling pathway";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Human cytomegalovirus infection";"Thermogenesis"
Mdes019935-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes004590-RA	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
Mdes009237-RA	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
Mdes009282-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Mdes011938-RA	1	Reactome: R-HSA-140342	"Apoptosis induced DNA fragmentation"
Mdes009385-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes001933-RA	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
Mdes005508-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Mdes009173-RA	11	Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-174437;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-69166;Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938	"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"Removal of the Flap Intermediate from the C-strand";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Removal of the Flap Intermediate";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)"
Mdes000773-RA	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
Mdes002968-RA	4	Reactome: R-HSA-3214847;Reactome: R-HSA-5689603;KEGG: 00514+2.4.1.255;MetaCyc: PWY-7437	"HATs acetylate histones";"UCH proteinases";"Other types of O-glycan biosynthesis";"Protein O-[N-acetyl]-glucosylation"
Mdes002338-RB	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes007872-RA	9	MetaCyc: PWY-6454;Reactome: R-HSA-5358346;Reactome: R-HSA-5362798;Reactome: R-HSA-373080;Reactome: R-HSA-5632684;MetaCyc: PWY-6455;Reactome: R-HSA-5632681;Reactome: R-HSA-5658034;Reactome: R-HSA-5635838	"Vancomycin resistance I";"Hedgehog ligand biogenesis";"Release of Hh-Np from the secreting cell";"Class B/2 (Secretin family receptors)";"Hedgehog 'on' state";"Vancomycin resistance II";"Ligand-receptor interactions";"HHAT G278V abrogates palmitoylation of Hh-Np";"Activation of SMO"
Mdes004477-RA	5	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-6782315;Reactome: R-HSA-5685942	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"tRNA modification in the nucleus and cytosol";"HDR through Homologous Recombination (HRR)"
Mdes008568-RA	2	Reactome: R-HSA-5694530;Reactome: R-HSA-204005	"Cargo concentration in the ER";"COPII-mediated vesicle transport"
Mdes012475-RA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.9	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes000606-RA	6	Reactome: R-HSA-68962;Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-68867	"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state";"Unwinding of DNA";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex"
Mdes006129-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Mdes009180-RA	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
Mdes007861-RC	6	MetaCyc: PWY-6123;MetaCyc: PWY-7234;KEGG: 00230+4.1.1.21;MetaCyc: PWY-6124;Reactome: R-HSA-73817;KEGG: 00230+6.3.2.6	"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III";"Purine metabolism";"Inosine-5'-phosphate biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism"
Mdes007171-RA	40	KEGG: 00410+4.2.1.17;KEGG: 00627+4.2.1.17;MetaCyc: PWY-5789;MetaCyc: PWY-7094;MetaCyc: PWY-7726;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-1361;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.35;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-5138;MetaCyc: PWY-6944;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;MetaCyc: PWY-7606;MetaCyc: PWY-5109;MetaCyc: PWY-6883;MetaCyc: PWY-6583;MetaCyc: PWY-7401;KEGG: 00623+1.1.1.35;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6946;MetaCyc: PWY-6945;MetaCyc: PWY-5136;KEGG: 00592+4.2.1.17;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;KEGG: 00640+4.2.1.17;MetaCyc: PWY-6435;MetaCyc: PWY-7654;MetaCyc: PWY-5177;KEGG: 00360+4.2.1.17;MetaCyc: PWY-7007;MetaCyc: PWY-6863;MetaCyc: PWY-7216;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00281+4.2.1.17+1.1.1.35	"beta-Alanine metabolism";"Aminobenzoate degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Fatty acid salvage";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Tryptophan metabolism";"2-methylpropene degradation";"Benzoyl-coa degradation I (aerobic)";"Valine, leucine and isoleucine degradation";"Carbon fixation pathways in prokaryotes";"Fatty acid degradation";"Benzoate degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Androstenedione degradation";"Caprolactam degradation";"Spodoptera littoralis pheromone biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fermentation to 2-methylbutanoate";"Pyruvate fermentation to butanol II (engineered)";"Pyruvate fermentation to butanol I";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Toluene degradation";"Limonene and pinene degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Fatty acid beta-oxidation II (plant peroxisome)";"alpha-Linolenic acid metabolism";"Lysine degradation";"Butanoate metabolism";"Methyl tert-butyl ether degradation";"Propanoate metabolism";"4-hydroxybenzoate biosynthesis III (plants)";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Glutaryl-coa degradation";"Phenylalanine metabolism";"Methyl ketone biosynthesis (engineered)";"Pyruvate fermentation to hexanol (engineered)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Fatty acid elongation";"Geraniol degradation"
Mdes019051-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes009782-RA	3	MetaCyc: PWY-7803;MetaCyc: PWY-6689;Reactome: R-HSA-6784531	"Trna splicing II";"Trna splicing I";"tRNA processing in the nucleus"
Mdes005924-RA	24	Reactome: R-HSA-354192;Reactome: R-HSA-114604;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-165158;Reactome: R-HSA-1257604;KEGG: 05163+2.7.11.1;Reactome: R-HSA-392451;KEGG: 04714+2.7.11.1;Reactome: R-HSA-444257;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-5674400;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6804757;Reactome: R-HSA-9634635;Reactome: R-HSA-5625740;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5607764;Reactome: R-HSA-5218921;KEGG: 04926+2.7.11.1;Reactome: R-HSA-2730905;Reactome: R-HSA-5218920	"Integrin signaling";"GPVI-mediated activation cascade";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Activation of AKT2";"PIP3 activates AKT signaling";"Human cytomegalovirus infection";"G beta:gamma signalling through PI3Kgamma";"Thermogenesis";"RSK activation";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"CD28 dependent PI3K/Akt signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"mTOR signaling pathway";"Regulation of TP53 Degradation";"Estrogen-stimulated signaling through PRKCZ";"RHO GTPases activate PKNs";"Human papillomavirus infection";"CLEC7A (Dectin-1) signaling";"VEGFR2 mediated cell proliferation";"Relaxin signaling pathway";"Role of LAT2/NTAL/LAB on calcium mobilization";"VEGFR2 mediated vascular permeability"
Mdes005721-RA	2	Reactome: R-HSA-6796648;Reactome: R-HSA-6783310	"TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway"
Mdes014534-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes002675-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes018676-RA	2	MetaCyc: PWY-7851;KEGG: 00770+2.7.7.3	"Coenzyme A biosynthesis II (eukaryotic)";"Pantothenate and CoA biosynthesis"
Mdes002695-RA	8	KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-9633012	"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes014651-RA	24	Reactome: R-HSA-418217;Reactome: R-HSA-500657;Reactome: R-HSA-456926;Reactome: R-HSA-8964616;Reactome: R-HSA-9009391;Reactome: R-HSA-418597;Reactome: R-HSA-416482;Reactome: R-HSA-202040;Reactome: R-HSA-381676;Reactome: R-HSA-428930;Reactome: R-HSA-4086398;Reactome: R-HSA-418592;Reactome: R-HSA-400042;Reactome: R-HSA-416476;Reactome: R-HSA-6814122;Reactome: R-HSA-8964315;Reactome: R-HSA-420092;Reactome: R-HSA-392170;Reactome: R-HSA-432040;Reactome: R-HSA-392451;Reactome: R-HSA-418594;Reactome: R-HSA-418555;Reactome: R-HSA-392851;Reactome: R-HSA-163359	"G beta:gamma signalling through PLC beta";"Presynaptic function of Kainate receptors";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through CDC42";"Extra-nuclear estrogen signaling";"G alpha (z) signalling events";"G alpha (12/13) signalling events";"G-protein activation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Thromboxane signalling through TP receptor";"Ca2+ pathway";"ADP signalling through P2Y purinoceptor 1";"Adrenaline,noradrenaline inhibits insulin secretion";"G alpha (q) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through BTK";"Glucagon-type ligand receptors";"ADP signalling through P2Y purinoceptor 12";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through PI3Kgamma";"G alpha (i) signalling events";"G alpha (s) signalling events";"Prostacyclin signalling through prostacyclin receptor";"Glucagon signaling in metabolic regulation"
Mdes016019-RA	7	Reactome: R-HSA-163210;KEGG: 00195+7.1.2.2;Reactome: R-HSA-2151201;MetaCyc: PWY-7980;Reactome: R-HSA-8949613;KEGG: 00190+7.1.2.2;Reactome: R-HSA-1268020	"Formation of ATP by chemiosmotic coupling";"Photosynthesis";"Transcriptional activation of mitochondrial biogenesis";"ATP biosynthesis";"Cristae formation";"Oxidative phosphorylation";"Mitochondrial protein import"
Mdes019725-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes000038-RA	1	Reactome: R-HSA-191859	"snRNP Assembly"
Mdes013025-RA	3	KEGG: 00220+3.5.1.14;Reactome: R-HSA-5579007;Reactome: R-HSA-5423646	"Arginine biosynthesis";"Defective ACY1 causes encephalopathy";"Aflatoxin activation and detoxification"
Mdes007858-RB	5	MetaCyc: PWY-4361;Reactome: R-HSA-111458;KEGG: 00270+4.2.1.109;Reactome: R-HSA-1237112;Reactome: R-HSA-9627069	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Formation of apoptosome";"Cysteine and methionine metabolism";"Methionine salvage pathway";"Regulation of the apoptosome activity"
Mdes008199-RA	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
Mdes007741-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Mdes009396-RA	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
Mdes009939-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Mdes003451-RB	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Mdes001129-RA	1	Reactome: R-HSA-8876725	"Protein methylation"
Mdes002065-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes000570-RB	3	Reactome: R-HSA-2559580;Reactome: R-HSA-8939243;Reactome: R-HSA-8943724	"Oxidative Stress Induced Senescence";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Regulation of PTEN gene transcription"
Mdes000120-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes003690-RF	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
Mdes009930-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Mdes012714-RA	7	Reactome: R-HSA-2132295;Reactome: R-HSA-1369062;Reactome: R-HSA-204005;Reactome: R-HSA-983170;Reactome: R-HSA-1655829;Reactome: R-HSA-5694530;Reactome: R-HSA-9603798	"MHC class II antigen presentation";"ABC transporters in lipid homeostasis";"COPII-mediated vesicle transport";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER";"Class I peroxisomal membrane protein import"
Mdes002882-RC	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes017642-RA	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
Mdes010432-RB	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes011736-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes009815-RA	5	MetaCyc: PWY-6987;KEGG: 00785+6.3.1.20;MetaCyc: PWY-7382;KEGG: 00785+2.3.1.181;Reactome: R-HSA-389661	"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism";"Glyoxylate metabolism and glycine degradation"
Mdes001611-RA	11	Reactome: R-HSA-4420097;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2559580;Reactome: R-HSA-450302;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-171007;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"VEGFA-VEGFR2 Pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Oxidative Stress Induced Senescence";"activated TAK1 mediates p38 MAPK activation";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"p38MAPK events";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway"
Mdes011097-RA	4	Reactome: R-HSA-8950505;Reactome: R-HSA-3371453;Reactome: R-HSA-8949613;Reactome: R-HSA-1268020	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Regulation of HSF1-mediated heat shock response";"Cristae formation";"Mitochondrial protein import"
Mdes006897-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes013127-RA	6	KEGG: 00020+4.2.1.3;Reactome: R-HSA-71403;KEGG: 00290+4.2.1.33;Reactome: R-HSA-1268020;KEGG: 00720+4.2.1.3;KEGG: 00630+4.2.1.3	"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Valine, leucine and isoleucine biosynthesis";"Mitochondrial protein import";"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism"
Mdes020102-RA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
Mdes015904-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Mdes005962-RB	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Mdes002218-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes011121-RA	3	Reactome: R-HSA-114608;Reactome: R-HSA-8957275;Reactome: R-HSA-381426	"Platelet degranulation";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
Mdes009755-RA	22	Reactome: R-HSA-5628897;MetaCyc: PWY-5659;Reactome: R-HSA-6798695;MetaCyc: PWY-7347;Reactome: R-HSA-70171;KEGG: 00500+5.3.1.9;MetaCyc: PWY-6992;KEGG: 00010+5.3.1.9;KEGG: 00030+5.3.1.9;MetaCyc: PWY-621;MetaCyc: PWY-8013;Reactome: R-HSA-70263;MetaCyc: PWY-622;MetaCyc: PWY-6142;MetaCyc: PWY-5384;MetaCyc: PWY-5514;MetaCyc: PWY-3801;MetaCyc: PWY-7238;MetaCyc: PWY-6981;MetaCyc: PWY-5054;KEGG: 00520+5.3.1.9;MetaCyc: PWY-7385	"TP53 Regulates Metabolic Genes";"GDP-mannose biosynthesis";"Neutrophil degranulation";"Sucrose biosynthesis III";"Glycolysis";"Starch and sucrose metabolism";"1,5-anhydrofructose degradation";"Glycolysis / Gluconeogenesis";"Pentose phosphate pathway";"Sucrose degradation III (sucrose invertase)";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Gluconeogenesis";"Starch biosynthesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Sucrose degradation IV (sucrose phosphorylase)";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Sucrose degradation II (sucrose synthase)";"Sucrose biosynthesis II";"Chitin biosynthesis";"D-sorbitol biosynthesis I";"Amino sugar and nucleotide sugar metabolism";"1,3-propanediol biosynthesis (engineered)"
Mdes007173-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes003611-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes000516-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Mdes014276-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Mdes000213-RE	7	MetaCyc: PWY-5469;MetaCyc: PWY-6824;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-5461;MetaCyc: PWY-7445	"Sesamin biosynthesis";"Justicidin B biosynthesis";"Phenylpropanoid biosynthesis";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Betanidin degradation";"Luteolin triglucuronide degradation"
Mdes011295-RA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
Mdes005744-RA	12	MetaCyc: PWY-4061;Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-156590;KEGG: 00480+2.5.1.18;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7112;MetaCyc: PWY-7533;KEGG: 00983+2.5.1.18;Reactome: R-HSA-264876;KEGG: 00980+2.5.1.18;MetaCyc: PWY-6842	"Glutathione-mediated detoxification I";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Glutathione conjugation";"Glutathione metabolism";"Drug metabolism - cytochrome P450";"4-hydroxy-2-nonenal detoxification";"Gliotoxin biosynthesis";"Drug metabolism - other enzymes";"Insulin processing";"Metabolism of xenobiotics by cytochrome P450";"Glutathione-mediated detoxification II"
Mdes001249-RB	14	Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-1912408;Reactome: R-HSA-203927;Reactome: R-HSA-426486;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Pre-NOTCH Transcription and Translation";"MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation"
Mdes000488-RA	56	Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-187577;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-5362768;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-5668541;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785	"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"SCF(Skp2)-mediated degradation of p27/p21";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"TNFR2 non-canonical NF-kB pathway";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome"
Mdes002177-RA	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes003430-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Mdes014823-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Mdes000402-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes014146-RC	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
Mdes004118-RB	19	MetaCyc: PWY-5046;KEGG: 00260+1.8.1.4;KEGG: 00010+1.8.1.4;KEGG: 00020+1.8.1.4;Reactome: R-HSA-204174;MetaCyc: PWY-5084;Reactome: R-HSA-71403;Reactome: R-HSA-71064;Reactome: R-HSA-70268;KEGG: 00380+1.8.1.4;KEGG: 00280+1.8.1.4;Reactome: R-HSA-389661;Reactome: R-HSA-70895;KEGG: 00640+1.8.1.4;Reactome: R-HSA-6783984;KEGG: 00620+1.8.1.4;KEGG: 00310+1.8.1.4;KEGG: 00970+6.1.1.2;Reactome: R-HSA-5362517	"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Glycine, serine and threonine metabolism";"Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)";"Regulation of pyruvate dehydrogenase (PDH) complex";"2-oxoglutarate decarboxylation to succinyl-CoA";"Citric acid cycle (TCA cycle)";"Lysine catabolism";"Pyruvate metabolism";"Tryptophan metabolism";"Valine, leucine and isoleucine degradation";"Glyoxylate metabolism and glycine degradation";"Branched-chain amino acid catabolism";"Propanoate metabolism";"Glycine degradation";"Pyruvate metabolism";"Lysine degradation";"Aminoacyl-tRNA biosynthesis";"Signaling by Retinoic Acid"
Mdes001891-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes013070-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Mdes010763-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
Mdes013101-RA	4	MetaCyc: PWY-6902;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822	"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)"
Mdes006430-RA	6	Reactome: R-HSA-8868766;Reactome: R-HSA-6785470;MetaCyc: PWY-6829;MetaCyc: PWY-7285;MetaCyc: PWY-7286;Reactome: R-HSA-6787450	"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion";"Trna methylation (yeast)";"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"tRNA modification in the mitochondrion"
Mdes002068-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Mdes010429-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes012881-RA	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
Mdes014006-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes004384-RA	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6785470	"tRNA processing in the nucleus";"tRNA processing in the mitochondrion"
Mdes017435-RA	5	MetaCyc: PWY-6277;KEGG: 00230+6.3.3.1;Reactome: R-HSA-73817;MetaCyc: PWY-6122;MetaCyc: PWY-6121	"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"5-aminoimidazole ribonucleotide biosynthesis I"
Mdes000025-RA	16	Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957	"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes002505-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes005975-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes006267-RA	1	Reactome: R-HSA-5419276	"Mitochondrial translation termination"
Mdes014786-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes014440-RA	42	Reactome: R-HSA-110330;Reactome: R-HSA-110329;Reactome: R-HSA-110331;Reactome: R-HSA-2299718;Reactome: R-HSA-5617472;Reactome: R-HSA-2559580;Reactome: R-HSA-110328;Reactome: R-HSA-5693565;Reactome: R-HSA-427359;Reactome: R-HSA-427413;Reactome: R-HSA-977225;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-2559582;Reactome: R-HSA-5250924;Reactome: R-HSA-912446;Reactome: R-HSA-212300;Reactome: R-HSA-1221632;Reactome: R-HSA-1912408;Reactome: R-HSA-9018519;Reactome: R-HSA-606279;Reactome: R-HSA-9616222;Reactome: R-HSA-171306;Reactome: R-HSA-5625886;Reactome: R-HSA-9610379;Reactome: R-HSA-2559586;Reactome: R-HSA-73772;Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-201722;Reactome: R-HSA-3214841;Reactome: R-HSA-3214847;Reactome: R-HSA-5578749;Reactome: R-HSA-8936459;Reactome: R-HSA-3214858;Reactome: R-HSA-69473;Reactome: R-HSA-3214842;Reactome: R-HSA-5693571;Reactome: R-HSA-8939236;Reactome: R-HSA-5334118;Reactome: R-HSA-73728;Reactome: R-HSA-5693607	"Recognition and association of DNA glycosylase with site containing an affected purine";"Cleavage of the damaged pyrimidine";"Cleavage of the damaged purine";"Condensation of Prophase Chromosomes";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Oxidative Stress Induced Senescence";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"SIRT1 negatively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"Amyloid fiber formation";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"Senescence-Associated Secretory Phenotype (SASP)";"B-WICH complex positively regulates rRNA expression";"Meiotic recombination";"PRC2 methylates histones and DNA";"Meiotic synapsis";"Pre-NOTCH Transcription and Translation";"Estrogen-dependent gene expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"Transcriptional regulation of granulopoiesis";"Packaging Of Telomere Ends";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"HCMV Late Events";"DNA Damage/Telomere Stress Induced Senescence";"RNA Polymerase I Promoter Escape";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines";"HATs acetylate histones";"Transcriptional regulation by small RNAs";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RMTs methylate histone arginines";"G2/M DNA damage checkpoint";"HDMs demethylate histones";"Nonhomologous End-Joining (NHEJ)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"DNA methylation";"RNA Polymerase I Promoter Opening";"Processing of DNA double-strand break ends"
Mdes017855-RA	1	Reactome: R-HSA-5635838	"Activation of SMO"
Mdes000809-RA	3	Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-381038	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"XBP1(S) activates chaperone genes"
Mdes004152-RA	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
Mdes004794-RA	1	Reactome: R-HSA-203754	"NOSIP mediated eNOS trafficking"
Mdes004310-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes007245-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes019393-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes011147-RA	1	KEGG: 00910+4.2.1.104	"Nitrogen metabolism"
Mdes007454-RB	15	Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-8936459;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398;Reactome: R-HSA-8948700;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-8853884;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-2559580;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569	"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by MECP2";"Ca2+ pathway";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by VENTX";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Oxidative Stress Induced Senescence";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
Mdes008396-RA	2	Reactome: R-HSA-8849473;Reactome: R-HSA-6791226	"PTK6 Expression";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes004292-RA	2	Reactome: R-HSA-9029569;Reactome: R-HSA-804914	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transport of fatty acids"
Mdes000258-RA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Mdes002028-RA	1	Reactome: R-HSA-9018519	"Estrogen-dependent gene expression"
Mdes012476-RA	2	Reactome: R-HSA-8873719;Reactome: R-HSA-8876198	"RAB geranylgeranylation";"RAB GEFs exchange GTP for GDP on RABs"
Mdes003592-RA	4	Reactome: R-HSA-3359462;Reactome: R-HSA-3359463;Reactome: R-HSA-8964011;Reactome: R-HSA-196741	"Defective AMN causes hereditary megaloblastic anemia 1";"Defective CUBN causes hereditary megaloblastic anemia 1";"HDL clearance";"Cobalamin (Cbl, vitamin B12) transport and metabolism"
Mdes001877-RA	1	Reactome: R-HSA-420029	"Tight junction interactions"
Mdes006143-RA	2	Reactome: R-HSA-1221632;Reactome: R-HSA-5601884	"Meiotic synapsis";"PIWI-interacting RNA (piRNA) biogenesis"
Mdes008308-RA	15	Reactome: R-HSA-674695;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-167162;Reactome: R-HSA-975957;Reactome: R-HSA-73779;Reactome: R-HSA-6807505;Reactome: R-HSA-167172;Reactome: R-HSA-9010553;Reactome: R-HSA-76042;Reactome: R-HSA-5419276;Reactome: R-HSA-75953;Reactome: R-HSA-73776	"RNA Polymerase II Pre-transcription Events";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"Mitochondrial translation initiation";"Mitochondrial translation elongation";"RNA Polymerase II HIV Promoter Escape";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA polymerase II transcribes snRNA genes";"Transcription of the HIV genome";"Regulation of expression of SLITs and ROBOs";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Mitochondrial translation termination";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape"
Mdes006851-RA	1	Reactome: R-HSA-977443	"GABA receptor activation"
Mdes018657-RA	3	Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-72163	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"mRNA Splicing - Major Pathway"
Mdes003546-RB	3	Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596	"Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I"
Mdes006149-RA	5	Reactome: R-HSA-159231;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-77595	"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs"
Mdes004105-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes012201-RB	2	KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7	"Aminobenzoate degradation";"Pyruvate metabolism"
Mdes018875-RA	15	Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-2559580;Reactome: R-HSA-9029569;Reactome: R-HSA-2559585;Reactome: R-HSA-5628897;Reactome: R-HSA-8936459;Reactome: R-HSA-8943723;Reactome: R-HSA-8986944;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-8853884	"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Oxidative Stress Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oncogene Induced Senescence";"TP53 Regulates Metabolic Genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by MECP2";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"Transcriptional Regulation by VENTX"
Mdes000747-RA	12	Reactome: R-HSA-6804756;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-167290	"Regulation of TP53 Activity through Phosphorylation";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation"
Mdes010311-RA	4	Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664	"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation"
Mdes019846-RA	2	Reactome: R-HSA-73614;Reactome: R-HSA-73621	"Pyrimidine salvage";"Pyrimidine catabolism"
Mdes010243-RD	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Mdes009152-RA	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
Mdes018505-RA	5	Reactome: R-HSA-3359469;Reactome: R-HSA-1614635;Reactome: R-HSA-3359467;Reactome: R-HSA-156581;Reactome: R-HSA-196741	"Defective MTR causes methylmalonic aciduria and homocystinuria type cblG";"Sulfur amino acid metabolism";"Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE";"Methylation";"Cobalamin (Cbl, vitamin B12) transport and metabolism"
Mdes005835-RA	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
Mdes013024-RA	3	MetaCyc: PWY-7174;MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism"
Mdes017057-RA	5	Reactome: R-HSA-2395516;Reactome: R-HSA-211976;Reactome: R-HSA-196108;Reactome: R-HSA-1362409;Reactome: R-HSA-5579026	"Electron transport from NADPH to Ferredoxin";"Endogenous sterols";"Pregnenolone biosynthesis";"Mitochondrial iron-sulfur cluster biogenesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"
Mdes000240-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Mdes006026-RA	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
Mdes005992-RB	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes016532-RA	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
Mdes003690-RD	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
Mdes007530-RA	3	MetaCyc: PWY-6829;Reactome: R-HSA-6782315;MetaCyc: PWY-7888	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol";"Trna-uridine 2-thiolation (cytoplasmic)"
Mdes014488-RA	7	Reactome: R-HSA-2122948;Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-9013507;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606	"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
Mdes007642-RA	10	MetaCyc: PWY-6372;Reactome: R-HSA-1855167;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6362;MetaCyc: PWY-6361;KEGG: 04070+2.7.1.158;MetaCyc: PWY-6554;MetaCyc: PWY-4661;MetaCyc: PWY-6369;Reactome: R-HSA-1855191	"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of pyrophosphates in the cytosol";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Inositol diphosphates biosynthesis";"Synthesis of IPs in the nucleus"
Mdes008270-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes016374-RA	58	Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-5668541;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-6798695;Reactome: R-HSA-5689901;Reactome: R-HSA-187577;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-211733;Reactome: R-HSA-69601	"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"TNFR2 non-canonical NF-kB pathway";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"Neutrophil degranulation";"Metalloprotease DUBs";"SCF(Skp2)-mediated degradation of p27/p21";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"
Mdes017895-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes008558-RB	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes000167-RB	14	Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-1632852;Reactome: R-HSA-5620924;Reactome: R-HSA-5663220	"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"HCMV Early Events";"Mitotic Prometaphase";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Separation of Sister Chromatids";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Macroautophagy";"Intraflagellar transport";"RHO GTPases Activate Formins"
Mdes003130-RB	6	KEGG: 00564+1.1.5.3;MetaCyc: PWY-6952;MetaCyc: PWY-6118;Reactome: R-HSA-163560;MetaCyc: PWY-4261;Reactome: R-HSA-1483166	"Glycerophospholipid metabolism";"Glycerophosphodiester degradation";"Glycerol-3-phosphate shuttle";"Triglyceride catabolism";"Glycerol degradation I";"Synthesis of PA"
Mdes002563-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes001278-RB	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
Mdes005464-RA	7	Reactome: R-HSA-162699;Reactome: R-HSA-4719360;Reactome: R-HSA-4719377;Reactome: R-HSA-162710;KEGG: 00760+2.7.1.173+2.7.1.22;Reactome: R-HSA-4717374;MetaCyc: PWY-5381	"Synthesis of dolichyl-phosphate mannose";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Synthesis of glycosylphosphatidylinositol (GPI)";"Nicotinate and nicotinamide metabolism";"Defective DPM1 causes DPM1-CDG (CDG-1e)";"Pyridine nucleotide cycling (plants)"
Mdes000512-RA	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
Mdes000086-RA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
Mdes009249-RA	18	KEGG: 00240+3.5.2.3;Reactome: R-HSA-165181;MetaCyc: PWY-5686;Reactome: R-HSA-500753;Reactome: R-HSA-1632852;MetaCyc: PWY-7790;KEGG: 00250+6.3.5.5;KEGG: 00240+2.1.3.2;MetaCyc: PWY-7791;Reactome: R-HSA-8854214;Reactome: R-HSA-5628897;KEGG: 00240+6.3.5.5;KEGG: 00250+2.1.3.2;Reactome: R-HSA-380972;MetaCyc: PWY-5154;MetaCyc: PWY-7400;Reactome: R-HSA-198323;Reactome: R-HSA-5674400	"Pyrimidine metabolism";"Inhibition of TSC complex formation by PKB";"UMP biosynthesis I";"Pyrimidine biosynthesis";"Macroautophagy";"UMP biosynthesis II";"Alanine, aspartate and glutamate metabolism";"Pyrimidine metabolism";"UMP biosynthesis III";"TBC/RABGAPs";"TP53 Regulates Metabolic Genes";"Pyrimidine metabolism";"Alanine, aspartate and glutamate metabolism";"Energy dependent regulation of mTOR by LKB1-AMPK";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"L-arginine biosynthesis IV (archaebacteria)";"AKT phosphorylates targets in the cytosol";"Constitutive Signaling by AKT1 E17K in Cancer"
Mdes001105-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes018375-RA	7	KEGG: 00430+1.4.1.2;KEGG: 00910+1.4.1.2;KEGG: 00250+1.4.1.2;KEGG: 00220+1.4.1.2;MetaCyc: PWY-7126;MetaCyc: PWY-6728;MetaCyc: PWY-5022	"Taurine and hypotaurine metabolism";"Nitrogen metabolism";"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis";"Ethylene biosynthesis IV (engineered)";"Methylaspartate cycle";"4-aminobutanoate degradation V"
Mdes002862-RA	4	Reactome: R-HSA-1650814;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216;Reactome: R-HSA-2022090	"Collagen biosynthesis and modifying enzymes";"Collagen degradation";"Collagen chain trimerization";"Assembly of collagen fibrils and other multimeric structures"
Mdes009946-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes011128-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Mdes012411-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes014803-RB	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Mdes014988-RA	2	Reactome: R-HSA-6803157;Reactome: R-HSA-6798695	"Antimicrobial peptides";"Neutrophil degranulation"
Mdes002238-RA	13	Reactome: R-HSA-1474244;Reactome: R-HSA-419037;Reactome: R-HSA-3000178;Reactome: R-HSA-186797;Reactome: R-HSA-2022090;Reactome: R-HSA-3000171;Reactome: R-HSA-1650814;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-2214320;Reactome: R-HSA-3000157;Reactome: R-HSA-216083;Reactome: R-HSA-2243919	"Extracellular matrix organization";"NCAM1 interactions";"ECM proteoglycans";"Signaling by PDGF";"Assembly of collagen fibrils and other multimeric structures";"Non-integrin membrane-ECM interactions";"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization";"Collagen degradation";"Anchoring fibril formation";"Laminin interactions";"Integrin cell surface interactions";"Crosslinking of collagen fibrils"
Mdes011033-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Mdes000357-RC	1	KEGG: 00860+4.4.1.17	"Porphyrin and chlorophyll metabolism"
Mdes007722-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Mdes010057-RB	5	KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7921;MetaCyc: PWY-7922	"Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)"
Mdes001750-RA	6	Reactome: R-HSA-111367;Reactome: R-HSA-191859;Reactome: R-HSA-73856;Reactome: R-HSA-72165;Reactome: R-HSA-77588;Reactome: R-HSA-72163	"SLBP independent Processing of Histone Pre-mRNAs";"snRNP Assembly";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Minor Pathway";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"mRNA Splicing - Major Pathway"
Mdes016856-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
Mdes001538-RA	4	Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Mdes017921-RA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Mdes003505-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes015031-RA	3	MetaCyc: PWY-7800;MetaCyc: PWY-7799;Reactome: R-HSA-2514859	"Ac/N-end rule pathway";"Arg/N-end rule pathway (eukaryotic)";"Inactivation, recovery and regulation of the phototransduction cascade"
Mdes018384-RA	16	Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-5419276;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957	"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Mitochondrial translation termination";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes011478-RA	5	Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-68949	"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex";"Unwinding of DNA";"Orc1 removal from chromatin"
Mdes015205-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes005454-RA	3	Reactome: R-HSA-191859;Reactome: R-HSA-72165;Reactome: R-HSA-72163	"snRNP Assembly";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Mdes016055-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes003792-RD	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
Mdes006338-RA	3	Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148	"Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes008602-RA	14	Reactome: R-HSA-70895;MetaCyc: PWY-5078;KEGG: 00270+2.6.1.42;MetaCyc: PWY-5057;KEGG: 00290+2.6.1.42;MetaCyc: PWY-5103;MetaCyc: PWY-5076;MetaCyc: PWY-5101;MetaCyc: PWY-7767;MetaCyc: PWY-5108;KEGG: 00966+2.6.1.42;KEGG: 00280+2.6.1.42;MetaCyc: PWY-5104;KEGG: 00770+2.6.1.42	"Branched-chain amino acid catabolism";"L-isoleucine degradation II";"Cysteine and methionine metabolism";"L-valine degradation II";"Valine, leucine and isoleucine biosynthesis";"L-isoleucine biosynthesis III";"L-leucine degradation III";"L-isoleucine biosynthesis II";"L-leucine degradation IV (Stickland reaction)";"L-isoleucine biosynthesis V";"Glucosinolate biosynthesis";"Valine, leucine and isoleucine degradation";"L-isoleucine biosynthesis IV";"Pantothenate and CoA biosynthesis"
Mdes009224-RB	1	Reactome: R-HSA-71064	"Lysine catabolism"
Mdes018641-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902	"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation"
Mdes018239-RA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
Mdes000456-RA	16	MetaCyc: PWY-5749;KEGG: 00020+6.2.1.5;KEGG: 00640+6.2.1.4;KEGG: 00660+6.2.1.5;MetaCyc: PWY-6728;MetaCyc: PWY-5537;MetaCyc: PWY-5392;MetaCyc: PWY-7384;MetaCyc: PWY-6969;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5913;KEGG: 00020+6.2.1.4;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;Reactome: R-HSA-71403;MetaCyc: PWY-5690	"Itaconate degradation";"Citrate cycle (TCA cycle)";"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"Methylaspartate cycle";"Pyruvate fermentation to acetate V";"Reductive TCA cycle II";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)"
Mdes000050-RB	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Mdes003519-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes002513-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes006437-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes014642-RA	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
Mdes010711-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes005524-RA	3	Reactome: R-HSA-391160;KEGG: 04660+2.7.10.2;Reactome: R-HSA-4420097	"Signal regulatory protein family interactions";"T cell receptor signaling pathway";"VEGFA-VEGFR2 Pathway"
Mdes015129-RA	4	Reactome: R-HSA-373753;Reactome: R-HSA-446388;Reactome: R-HSA-3000170;Reactome: R-HSA-114608	"Nephrin family interactions";"Regulation of cytoskeletal remodeling and cell spreading by IPP complex components";"Syndecan interactions";"Platelet degranulation"
Mdes008413-RC	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes015421-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes000287-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes006367-RB	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes005019-RA	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
Mdes001180-RA	57	Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-5668541;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-187577;Reactome: R-HSA-6798695;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-5607764;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-75815;Reactome: R-HSA-8939236	"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"TNFR2 non-canonical NF-kB pathway";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"SCF(Skp2)-mediated degradation of p27/p21";"Neutrophil degranulation";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"CLEC7A (Dectin-1) signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
Mdes002744-RA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
Mdes010964-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes007781-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes015581-RA	14	MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7036;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7724;MetaCyc: PWY-7035	"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis"
Mdes017537-RA	3	Reactome: R-HSA-5362517;Reactome: R-HSA-204174;Reactome: R-HSA-1296072	"Signaling by Retinoic Acid";"Regulation of pyruvate dehydrogenase (PDH) complex";"Voltage gated Potassium channels"
Mdes003528-RB	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
Mdes009174-RB	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes008267-RB	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes008068-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes011125-RA	14	KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051;KEGG: 00591+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7783;MetaCyc: PWY-7417;MetaCyc: PWY-7416;MetaCyc: PWY-6803;Reactome: R-HSA-975634;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-7409;Reactome: R-HSA-1482788	"Ether lipid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis I";"Linoleic acid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis II";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phosphatidylcholine acyl editing";"Retinoid metabolism and transport";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PC"
Mdes018317-RA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes012532-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes004727-RA	5	KEGG: 00514+2.4.1.109;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7979;MetaCyc: PWY-7922	"Other types of O-glycan biosynthesis";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)"
Mdes011563-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes014183-RB	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
Mdes004569-RA	16	Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764	"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination"
Mdes003636-RA	1	KEGG: 00051+4.2.1.68	"Fructose and mannose metabolism"
Mdes018745-RA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
Mdes006118-RA	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
Mdes018094-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Mdes004598-RA	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
Mdes008287-RA	3	Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840	"G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle"
Mdes003026-RA	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes010599-RA	15	Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-2559580;Reactome: R-HSA-9029569;Reactome: R-HSA-2559585;Reactome: R-HSA-8936459;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723;Reactome: R-HSA-8986944;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-8853884	"Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Oxidative Stress Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oncogene Induced Senescence";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by MECP2";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"Transcriptional Regulation by VENTX"
Mdes006427-RB	1	Reactome: R-HSA-5676934	"Protein repair"
Mdes009348-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes001303-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes001509-RA	3	Reactome: R-HSA-191859;Reactome: R-HSA-72163;Reactome: R-HSA-72165	"snRNP Assembly";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Mdes013985-RA	7	MetaCyc: PWY-5466;KEGG: 00940+1.11.1.7;MetaCyc: PWY-6824;MetaCyc: PWY-5469;MetaCyc: PWY-5461;MetaCyc: PWY-7445;MetaCyc: PWY-7214	"Matairesinol biosynthesis";"Phenylpropanoid biosynthesis";"Justicidin B biosynthesis";"Sesamin biosynthesis";"Betanidin degradation";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)"
Mdes008140-RE	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway"
Mdes004935-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Mdes019523-RA	1	KEGG: 00340+1.1.1.23	"Histidine metabolism"
Mdes000907-RA	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
Mdes012002-RF	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes012664-RA	5	Reactome: R-HSA-2559580;Reactome: R-HSA-2871796;Reactome: R-HSA-450321;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341	"Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"mTOR signaling pathway";"Activation of the AP-1 family of transcription factors"
Mdes010776-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes005808-RA	2	Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (q) signalling events";"Peptide ligand-binding receptors"
Mdes007776-RA	5	MetaCyc: PWY-7391;MetaCyc: PWY-922;Reactome: R-HSA-2426168;Reactome: R-HSA-191273;KEGG: 00900+2.7.4.2	"Isoprene biosynthesis II (engineered)";"Mevalonate pathway I";"Activation of gene expression by SREBF (SREBP)";"Cholesterol biosynthesis";"Terpenoid backbone biosynthesis"
Mdes013070-RB	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Mdes018248-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes014206-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Mdes012487-RA	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
Mdes007395-RA	30	Reactome: R-HSA-1170546;Reactome: R-HSA-2644607;Reactome: R-HSA-187577;Reactome: R-HSA-400253;Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-69231;Reactome: R-HSA-195253;Reactome: R-HSA-2122947;Reactome: R-HSA-8854050;Reactome: R-HSA-5610785;Reactome: R-HSA-2894862;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-5684264;Reactome: R-HSA-2565942;Reactome: R-HSA-5607761;Reactome: R-HSA-180534;Reactome: R-HSA-8939902;Reactome: R-HSA-917937;Reactome: R-HSA-5607764;Reactome: R-HSA-2644606;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590	"Prolactin receptor signaling";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Circadian Clock";"Downstream TCR signaling";"FCERI mediated NF-kB activation";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"Cyclin D associated events in G1";"Degradation of beta-catenin by the destruction complex";"NOTCH1 Intracellular Domain Regulates Transcription";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"GLI3 is processed to GLI3R by the proteasome";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Regulation of PLK1 Activity at G2/M Transition";"Dectin-1 mediated noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"Regulation of RUNX2 expression and activity";"Iron uptake and transport";"CLEC7A (Dectin-1) signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling"
Mdes015905-RA	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
Mdes007129-RB	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes013509-RA	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.15	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes006274-RA	56	Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5668541;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-187577;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815	"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"TNFR2 non-canonical NF-kB pathway";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"SCF(Skp2)-mediated degradation of p27/p21";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Ub-specific processing proteases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D"
Mdes000709-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes010375-RA	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
Mdes013758-RA	27	Reactome: R-HSA-113418;Reactome: R-HSA-77595;Reactome: R-HSA-77588;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-112382;Reactome: R-HSA-72165;Reactome: R-HSA-167242;Reactome: R-HSA-72163;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-8851708;Reactome: R-HSA-159227;Reactome: R-HSA-167158;Reactome: R-HSA-72187;Reactome: R-HSA-6803529;Reactome: R-HSA-111367;Reactome: R-HSA-73856;Reactome: R-HSA-72203;Reactome: R-HSA-167200;Reactome: R-HSA-975957;Reactome: R-HSA-159236;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-674695	"Formation of the Early Elongation Complex";"Processing of Intronless Pre-mRNAs";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"Formation of RNA Pol II elongation complex";"mRNA Splicing - Minor Pathway";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Major Pathway";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Signaling by FGFR2 IIIa TM";"Transport of the SLBP independent Mature mRNA";"Formation of the HIV-1 Early Elongation Complex";"mRNA 3'-end processing";"FGFR2 alternative splicing";"SLBP independent Processing of Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"RNA Polymerase II Pre-transcription Events"
Mdes016975-RA	7	MetaCyc: PWY-7791;KEGG: 00250+6.3.5.5;MetaCyc: PWY-5154;MetaCyc: PWY-7400;MetaCyc: PWY-5686;KEGG: 00240+6.3.5.5;MetaCyc: PWY-7790	"UMP biosynthesis III";"Alanine, aspartate and glutamate metabolism";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"L-arginine biosynthesis IV (archaebacteria)";"UMP biosynthesis I";"Pyrimidine metabolism";"UMP biosynthesis II"
Mdes016382-RB	5	KEGG: 00240+6.3.4.2;MetaCyc: PWY-7177;MetaCyc: PWY-7176;Reactome: R-HSA-499943;MetaCyc: PWY-7185	"Pyrimidine metabolism";"UTP and CTP dephosphorylation II";"UTP and CTP de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"UTP and CTP dephosphorylation I"
Mdes019707-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes015085-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes008946-RB	14	Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723;Reactome: R-HSA-426486;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-1912408;Reactome: R-HSA-203927;Reactome: R-HSA-9029569;Reactome: R-HSA-426496	"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation";"Small interfering RNA (siRNA) biogenesis";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Pre-NOTCH Transcription and Translation";"MicroRNA (miRNA) biogenesis";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs"
Mdes005000-RB	12	MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis I"
Mdes002803-RA	4	Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic"
Mdes004799-RA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
Mdes010775-RA	29	Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-73772;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-427413;Reactome: R-HSA-5696395;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-73762;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-73779;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167162	"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"Dual incision in TC-NER";"Dual Incision in GG-NER";"NoRC negatively regulates rRNA expression";"Formation of Incision Complex in GG-NER";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Initiation";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape"
Mdes006616-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes000899-RA	11	Reactome: R-HSA-167238;Reactome: R-HSA-167200;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-167152	"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat"
Mdes012418-RA	32	Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;KEGG: 00500+2.4.1.1;Reactome: R-HSA-190840;Reactome: R-HSA-3371497;MetaCyc: PWY-7238;Reactome: R-HSA-9609736;Reactome: R-HSA-380320;Reactome: R-HSA-8955332;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;MetaCyc: PWY-6731;MetaCyc: PWY-6737;Reactome: R-HSA-190861;Reactome: R-HSA-9648025;Reactome: R-HSA-1445148;Reactome: R-HSA-5663220;Reactome: R-HSA-983189;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-2467813;Reactome: R-HSA-70221;Reactome: R-HSA-5626467;Reactome: R-HSA-437239;MetaCyc: PWY-5941;Reactome: R-HSA-9646399;Reactome: R-HSA-389960;Reactome: R-HSA-389977;Reactome: R-HSA-9619483;Reactome: R-HSA-8852276;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"Starch and sucrose metabolism";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Sucrose biosynthesis II";"Assembly and cell surface presentation of NMDA receptors";"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin";"Mitotic Prometaphase";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Starch degradation III";"Starch degradation V";"Gap junction assembly";"EML4 and NUDC in mitotic spindle formation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases Activate Formins";"Kinesins";"Cilium Assembly";"MHC class II antigen presentation";"Separation of Sister Chromatids";"Glycogen breakdown (glycogenolysis)";"RHO GTPases activate IQGAPs";"Recycling pathway of L1";"Glycogen degradation II";"Aggrephagy";"Formation of tubulin folding intermediates by CCT/TriC";"Post-chaperonin tubulin folding pathway";"Activation of AMPK downstream of NMDARs";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes003337-RA	20	Reactome: R-HSA-5696400;Reactome: R-HSA-5655862;Reactome: R-HSA-5685938;Reactome: R-HSA-5651801;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5656121;Reactome: R-HSA-6782210;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-110320;Reactome: R-HSA-69091;Reactome: R-HSA-5693616;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-6782135	"Dual Incision in GG-NER";"Translesion synthesis by POLK";"HDR through Single Strand Annealing (SSA)";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"Translesion Synthesis by POLH";"Polymerase switching";"Presynaptic phase of homologous DNA pairing and strand exchange";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"Dual incision in TC-NER"
Mdes011563-RB	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes017287-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes005358-RC	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Mdes013839-RA	2	Reactome: R-HSA-1236974;Reactome: R-HSA-1799339	"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane"
Mdes015910-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Mdes005495-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Relaxin signaling pathway"
Mdes010696-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes009095-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes000793-RB	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes005782-RA	1	Reactome: R-HSA-5676934	"Protein repair"
Mdes014940-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes001638-RA	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
Mdes004712-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes006842-RA	10	KEGG: 00460+2.3.2.2;MetaCyc: PWY-7112;MetaCyc: PWY-5826;MetaCyc: PWY-6842;MetaCyc: PWY-7559;MetaCyc: PWY-4041;KEGG: 00430+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-8001;MetaCyc: PWY-4061	"Cyanoamino acid metabolism";"4-hydroxy-2-nonenal detoxification";"Hypoglycin biosynthesis";"Glutathione-mediated detoxification II";"Glutathione degradation (DUG pathway";"Gamma-glutamyl cycle";"Taurine and hypotaurine metabolism";"Glutathione metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I"
Mdes002503-RA	2	KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I"
Mdes004785-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes002801-RA	16	Reactome: R-HSA-176409;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-2559582;Reactome: R-HSA-176408;Reactome: R-HSA-174154;Reactome: R-HSA-174048;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-8853884;Reactome: R-HSA-176412;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-179409	"APC/C:Cdc20 mediated degradation of mitotic proteins";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Senescence-Associated Secretory Phenotype (SASP)";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdc20 mediated degradation of Cyclin B";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Transcriptional Regulation by VENTX";"Phosphorylation of the APC/C";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"APC-Cdc20 mediated degradation of Nek2A"
Mdes004835-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes004377-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes014013-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes013293-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes008674-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes007936-RA	6	Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72649	"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation"
Mdes007725-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes000578-RA	4	Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827	"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
Mdes009234-RB	2	Reactome: R-HSA-9639288;Reactome: R-HSA-194840	"Amino acids regulate mTORC1";"Rho GTPase cycle"
Mdes010432-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes009036-RB	11	Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756;Reactome: R-HSA-5358565;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5358606	"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"
Mdes005293-RA	2	Reactome: R-HSA-1799339;Reactome: R-HSA-446203	"SRP-dependent cotranslational protein targeting to membrane";"Asparagine N-linked glycosylation"
Mdes009700-RA	3	Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355	"Nitric oxide stimulates guanylate cyclase";"Purine metabolism";"Smooth Muscle Contraction"
Mdes017438-RA	5	Reactome: R-HSA-1989781;Reactome: R-HSA-211981;Reactome: R-HSA-211945;Reactome: R-HSA-8937144;Reactome: R-HSA-211976	"PPARA activates gene expression";"Xenobiotics";"Phase I - Functionalization of compounds";"Aryl hydrocarbon receptor signalling";"Endogenous sterols"
Mdes001636-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes001686-RA	1	Reactome: R-HSA-5649702	"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"
Mdes008505-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes010120-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes018764-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes010319-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes002415-RA	3	Reactome: R-HSA-3214858;Reactome: R-HSA-6804760;Reactome: R-HSA-191859	"RMTs methylate histone arginines";"Regulation of TP53 Activity through Methylation";"snRNP Assembly"
Mdes000845-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes001834-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes018982-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes009576-RA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220	"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins"
Mdes000400-RA	6	KEGG: 04070+3.1.3.56;MetaCyc: PWY-6364;MetaCyc: PWY-6363;MetaCyc: PWY-6362;Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.56	"Phosphatidylinositol signaling system";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism"
Mdes010283-RA	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
Mdes013267-RA	29	Reactome: R-HSA-5685942;Reactome: R-HSA-3371511;Reactome: R-HSA-5651801;Reactome: R-HSA-5685938;Reactome: R-HSA-69166;Reactome: R-HSA-3108214;Reactome: R-HSA-6783310;Reactome: R-HSA-5696400;Reactome: R-HSA-5655862;Reactome: R-HSA-5696395;Reactome: R-HSA-3371453;Reactome: R-HSA-5358565;Reactome: R-HSA-6804756;Reactome: R-HSA-5656121;Reactome: R-HSA-69473;Reactome: R-HSA-176187;Reactome: R-HSA-5358606;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-110312;Reactome: R-HSA-110320;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-174437;Reactome: R-HSA-68962;Reactome: R-HSA-5693616;Reactome: R-HSA-110314	"HDR through Homologous Recombination (HRR)";"HSF1 activation";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Single Strand Annealing (SSA)";"Removal of the Flap Intermediate";"SUMOylation of DNA damage response and repair proteins";"Fanconi Anemia Pathway";"Dual Incision in GG-NER";"Translesion synthesis by POLK";"Formation of Incision Complex in GG-NER";"Regulation of HSF1-mediated heat shock response";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Regulation of TP53 Activity through Phosphorylation";"Translesion synthesis by POLI";"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Processing of DNA double-strand break ends";"Meiotic recombination";"Translesion synthesis by REV1";"Translesion Synthesis by POLH";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Removal of the Flap Intermediate from the C-strand";"Activation of the pre-replicative complex";"Presynaptic phase of homologous DNA pairing and strand exchange";"Recognition of DNA damage by PCNA-containing replication complex"
Mdes005850-RA	3	KEGG: 00260+2.1.2.10;Reactome: R-HSA-6783984;KEGG: 00670+2.1.2.10	"Glycine, serine and threonine metabolism";"Glycine degradation";"One carbon pool by folate"
Mdes010271-RA	3	Reactome: R-HSA-6807505;Reactome: R-HSA-749476;Reactome: R-HSA-76071	"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter"
Mdes012196-RA	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)"
Mdes006631-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes002338-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes010074-RA	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
Mdes004489-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes003073-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes006387-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-159231;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"Transport of Mature mRNA Derived from an Intronless Transcript";"RNA Polymerase II Transcription Termination"
Mdes016552-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes002008-RA	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
Mdes015852-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes010683-RA	7	Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-76071	"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter"
Mdes018914-RA	3	KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348	"Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition"
Mdes001556-RB	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes014450-RA	5	Reactome: R-HSA-9615710;Reactome: R-HSA-917729;Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-174490	"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events";"Budding and maturation of HIV virion";"Membrane binding and targetting of GAG proteins"
Mdes007675-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-390450;Reactome: R-HSA-6814122	"Association of TriC/CCT with target proteins during biosynthesis";"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
Mdes011652-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1362409	"Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis"
Mdes004283-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes006519-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes011287-RB	16	Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957	"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes016412-RA	2	Reactome: R-HSA-70263;Reactome: R-HSA-70171	"Gluconeogenesis";"Glycolysis"
Mdes010006-RA	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
Mdes013426-RA	6	MetaCyc: PWY-6367;MetaCyc: PWY-6368;MetaCyc: PWY-6580;Reactome: R-HSA-1660499;KEGG: 00562+3.1.3.64+3.1.3.95;KEGG: 04070+3.1.3.64+3.1.3.95	"D-myo-inositol-5-phosphate metabolism";"3-phosphoinositide degradation";"Phosphatidylinositol biosynthesis I (bacteria)";"Synthesis of PIPs at the plasma membrane";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system"
Mdes007686-RA	3	MetaCyc: PWY-7799;MetaCyc: PWY-7800;Reactome: R-HSA-2514859	"Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway";"Inactivation, recovery and regulation of the phototransduction cascade"
Mdes008446-RA	2	Reactome: R-HSA-5633231;Reactome: R-HSA-446193	"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
Mdes000950-RA	4	Reactome: R-HSA-1799339;Reactome: R-HSA-400511;Reactome: R-HSA-422085;Reactome: R-HSA-381771	"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"
Mdes015349-RA	3	Reactome: R-HSA-975574;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.144	"Reactions specific to the hybrid N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis"
Mdes020106-RA	1	Reactome: R-HSA-186797	"Signaling by PDGF"
Mdes007340-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Mdes012731-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes004052-RA	16	Reactome: R-HSA-5603037;Reactome: R-HSA-975138;Reactome: R-HSA-3134963;Reactome: R-HSA-5603041;Reactome: R-HSA-1257604;Reactome: R-HSA-166058;Reactome: R-HSA-5602498;Reactome: R-HSA-1810476;Reactome: R-HSA-975110;Reactome: R-HSA-975871;Reactome: R-HSA-1236974;Reactome: R-HSA-975155;Reactome: R-HSA-9020702;Reactome: R-HSA-5602680;Reactome: R-HSA-6811558;Reactome: R-HSA-209543	"IRAK4 deficiency (TLR5)";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"IRAK4 deficiency (TLR2/4)";"PIP3 activates AKT signaling";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"MyD88 deficiency (TLR2/4)";"RIP-mediated NFkB activation via ZBP1";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"MyD88 cascade initiated on plasma membrane";"ER-Phagosome pathway";"MyD88 dependent cascade initiated on endosome";"Interleukin-1 signaling";"MyD88 deficiency (TLR5)";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"p75NTR recruits signalling complexes"
Mdes014135-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes008173-RA	2	Reactome: R-HSA-913709;Reactome: R-HSA-197264	"O-linked glycosylation of mucins";"Nicotinamide salvaging"
Mdes012057-RA	1	Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis"
Mdes014319-RA	3	KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2	"Thiamine metabolism";"Phosphate acquisition";"Riboflavin metabolism"
Mdes005873-RA	3	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
Mdes003924-RA	4	Reactome: R-HSA-983231;Reactome: R-HSA-1170546;Reactome: R-HSA-982772;Reactome: R-HSA-2586552	"Factors involved in megakaryocyte development and platelet production";"Prolactin receptor signaling";"Growth hormone receptor signaling";"Signaling by Leptin"
Mdes001583-RA	14	Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-167158;Reactome: R-HSA-167290;Reactome: R-HSA-167243;Reactome: R-HSA-167200;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-674695	"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events"
Mdes013735-RA	7	MetaCyc: PWY-7841;MetaCyc: PWY-5129;KEGG: 00600+2.4.1.80;MetaCyc: PWY-7839;MetaCyc: PWY-7838;MetaCyc: PWY-7836;Reactome: R-HSA-1660662	"Neolacto-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)";"Sphingolipid metabolism";"Lacto-series glycosphingolipids biosynthesis";"Globo-series glycosphingolipids biosynthesis";"Ganglio-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism"
Mdes002506-RA	11	Reactome: R-HSA-6804756;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-380972;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9614657;KEGG: 04714+2.7.11.1;Reactome: R-HSA-163680;KEGG: 04926+2.7.11.1	"Regulation of TP53 Activity through Phosphorylation";"Human papillomavirus infection";"mTOR signaling pathway";"Energy dependent regulation of mTOR by LKB1-AMPK";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"FOXO-mediated transcription of cell death genes";"Thermogenesis";"AMPK inhibits chREBP transcriptional activation activity";"Relaxin signaling pathway"
Mdes007414-RC	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes017498-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Mdes001680-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes015816-RA	12	Reactome: R-HSA-3928665;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-9017802;Reactome: R-HSA-205043;Reactome: R-HSA-9013507;Reactome: R-HSA-9013700;Reactome: R-HSA-193692;Reactome: R-HSA-977225;Reactome: R-HSA-1251985;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862	"EPH-ephrin mediated repulsion of cells";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Noncanonical activation of NOTCH3";"NRIF signals cell death from the nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Regulated proteolysis of p75NTR";"Amyloid fiber formation";"Nuclear signaling by ERBB4";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
Mdes005324-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Mdes013891-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes019258-RA	18	Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-167242;Reactome: R-HSA-77075;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167287	"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery"
Mdes016407-RA	12	Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-3371497	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Aggrephagy";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Mdes006958-RA	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
Mdes016034-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes005532-RD	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
Mdes000357-RB	1	KEGG: 00860+4.4.1.17	"Porphyrin and chlorophyll metabolism"
Mdes003409-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340	"PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation"
Mdes002942-RA	2	Reactome: R-HSA-446203;Reactome: R-HSA-1799339	"Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane"
Mdes007585-RA	1	Reactome: R-HSA-5666185	"RHO GTPases Activate Rhotekin and Rhophilins"
Mdes008282-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes017560-RA	1	KEGG: 00340+1.1.1.23	"Histidine metabolism"
Mdes002403-RA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
Mdes000757-RA	3	Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840	"G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle"
Mdes002654-RA	7	KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1	"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway"
Mdes010992-RA	3	Reactome: R-HSA-373080;Reactome: R-HSA-4608870;Reactome: R-HSA-4086400	"Class B/2 (Secretin family receptors)";"Asymmetric localization of PCP proteins";"PCP/CE pathway"
Mdes012094-RB	2	Reactome: R-HSA-1566948;Reactome: R-HSA-2243919	"Elastic fibre formation";"Crosslinking of collagen fibrils"
Mdes017123-RB	6	KEGG: 00630+1.11.1.6;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;Reactome: R-HSA-9033241;Reactome: R-HSA-6798695	"Glyoxylate and dicarboxylate metabolism";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Peroxisomal protein import";"Neutrophil degranulation"
Mdes000639-RC	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Mdes007738-RA	5	MetaCyc: PWY-7219;KEGG: 00230+2.7.4.10;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3	"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Thiamine metabolism"
Mdes010371-RA	1	Reactome: R-HSA-5676934	"Protein repair"
Mdes017408-RA	6	Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72689	"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits"
Mdes010374-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes013004-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes009830-RB	7	Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912	"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane"
Mdes011997-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression"
Mdes011551-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis"
Mdes000461-RA	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
Mdes006269-RA	2	Reactome: R-HSA-71288;MetaCyc: PWY-7511	"Creatine metabolism";"Protein ubiquitination"
Mdes017349-RA	14	MetaCyc: PWY-5497;KEGG: 00460+2.1.2.1;KEGG: 00630+2.1.2.1;KEGG: 00670+2.1.2.1;MetaCyc: PWY-3661-1;KEGG: 00260+2.1.2.1;Reactome: R-HSA-196757;MetaCyc: PWY-181;MetaCyc: PWY-3841;KEGG: 00680+2.1.2.1;MetaCyc: PWY-1622;MetaCyc: PWY-2161;MetaCyc: PWY-3661;MetaCyc: PWY-2201	"Purine nucleobases degradation II (anaerobic)";"Cyanoamino acid metabolism";"Glyoxylate and dicarboxylate metabolism";"One carbon pool by folate";"Glycine betaine degradation II (mammalian)";"Glycine, serine and threonine metabolism";"Metabolism of folate and pterines";"Photorespiration ";"Folate transformations II (plants)";"Methane metabolism";"Formaldehyde assimilation I (serine pathway)";"Folate polyglutamylation";"Glycine betaine degradation I";"Folate transformations I"
Mdes004538-RB	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
Mdes015089-RA	6	MetaCyc: PWY-7285;MetaCyc: PWY-7286;MetaCyc: PWY-6829;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470;Reactome: R-HSA-6787450	"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Trna methylation (yeast)";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion";"tRNA modification in the mitochondrion"
Mdes016190-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Mdes008472-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes018691-RA	14	MetaCyc: PWY-3781;Reactome: R-HSA-611105;MetaCyc: PWY-6969;MetaCyc: PWY-4302;MetaCyc: PWY-561;MetaCyc: PWY-7279;KEGG: 00720+1.3.5.1;MetaCyc: PWY-6728;MetaCyc: PWY-5690;Reactome: R-HSA-71403;KEGG: 00020+1.3.5.1;MetaCyc: PWY-7254;KEGG: 00650+1.3.5.1;KEGG: 00190+1.3.5.1	"Aerobic respiration I (cytochrome c)";"Respiratory electron transport";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration II (cytochrome c) (yeast)";"Carbon fixation pathways in prokaryotes";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Butanoate metabolism";"Oxidative phosphorylation"
Mdes000123-RA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-9033241;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685;KEGG: 00630+1.11.1.6	"Neutrophil degranulation";"Peroxisomal protein import";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species";"Glyoxylate and dicarboxylate metabolism"
Mdes005371-RA	5	MetaCyc: PWY-6614;KEGG: 00790+1.5.1.3;Reactome: R-HSA-196757;KEGG: 00670+1.5.1.3;MetaCyc: PWY-3841	"Tetrahydrofolate biosynthesis";"Folate biosynthesis";"Metabolism of folate and pterines";"One carbon pool by folate";"Folate transformations II (plants)"
Mdes004694-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes015716-RA	1	Reactome: R-HSA-193648	"NRAGE signals death through JNK"
Mdes015476-RA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs"
Mdes010399-RA	3	Reactome: R-HSA-6799198;Reactome: R-HSA-5389840;Reactome: R-HSA-611105	"Complex I biogenesis";"Mitochondrial translation elongation";"Respiratory electron transport"
Mdes000585-RB	21	KEGG: 00680+2.6.1.52;MetaCyc: PWY-1042;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40;Reactome: R-HSA-70171;KEGG: 00010+2.7.1.40;MetaCyc: PWY-7383;KEGG: 00620+2.7.1.40;KEGG: 00750+2.6.1.52;MetaCyc: PWY-7003;KEGG: 00270+2.6.1.52;MetaCyc: PWY-8010;KEGG: 00260+2.6.1.52;MetaCyc: PWY-8004;MetaCyc: PWY-6142;MetaCyc: PWY-2221;MetaCyc: PWY-6901;MetaCyc: PWY-6886;MetaCyc: PWY-5723;MetaCyc: PWY-7218;Reactome: R-HSA-977347	"Methane metabolism";"Glycolysis IV (plant cytosol)";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism";"Glycolysis";"Glycolysis / Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Pyruvate metabolism";"Vitamin B6 metabolism";"Glycerol degradation to butanol";"Cysteine and methionine metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Superpathway of glucose and xylose degradation";"1-butanol autotrophic biosynthesis (engineered)";"Rubisco shunt";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Serine biosynthesis"
Mdes000673-RA	4	Reactome: R-HSA-8866654;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955	"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation"
Mdes003809-RA	4	Reactome: R-HSA-6782315;Reactome: R-HSA-6787450;KEGG: 00908+2.5.1.75;MetaCyc: PWY-2781	"tRNA modification in the nucleus and cytosol";"tRNA modification in the mitochondrion";"Zeatin biosynthesis";"Cis-zeatin biosynthesis"
Mdes001726-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes007578-RA	5	KEGG: 04658+3.1.3.16;Reactome: R-HSA-112409;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-5675221	"Th1 and Th2 cell differentiation";"RAF-independent MAPK1/3 activation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Negative regulation of MAPK pathway"
Mdes009931-RB	11	Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-5610787;Reactome: R-HSA-432040;Reactome: R-HSA-170660;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-163615;Reactome: R-HSA-164378	"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"Hedgehog 'off' state";"Vasopressin regulates renal water homeostasis via Aquaporins";"Adenylate cyclase activating pathway";"G alpha (i) signalling events";"Purine metabolism";"G alpha (s) signalling events";"G alpha (z) signalling events";"PKA activation";"PKA activation in glucagon signalling"
Mdes015978-RA	3	KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980;KEGG: 00195+7.1.2.2	"Oxidative phosphorylation";"ATP biosynthesis";"Photosynthesis"
Mdes015837-RA	16	Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-167152;Reactome: R-HSA-8951664;Reactome: R-HSA-674695;Reactome: R-HSA-983168;Reactome: R-HSA-180585;Reactome: R-HSA-167200	"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Formation of HIV elongation complex in the absence of HIV Tat";"Neddylation";"RNA Polymerase II Pre-transcription Events";"Antigen processing: Ubiquitination & Proteasome degradation";"Vif-mediated degradation of APOBEC3G";"Formation of HIV-1 elongation complex containing HIV-1 Tat"
Mdes003868-RA	42	Reactome: R-HSA-5617472;Reactome: R-HSA-2559580;Reactome: R-HSA-5693565;Reactome: R-HSA-110328;Reactome: R-HSA-110329;Reactome: R-HSA-110330;Reactome: R-HSA-2299718;Reactome: R-HSA-110331;Reactome: R-HSA-9609690;Reactome: R-HSA-2559582;Reactome: R-HSA-212300;Reactome: R-HSA-5250924;Reactome: R-HSA-912446;Reactome: R-HSA-1912408;Reactome: R-HSA-9018519;Reactome: R-HSA-606279;Reactome: R-HSA-1221632;Reactome: R-HSA-427359;Reactome: R-HSA-977225;Reactome: R-HSA-427413;Reactome: R-HSA-4551638;Reactome: R-HSA-427389;Reactome: R-HSA-201722;Reactome: R-HSA-3214841;Reactome: R-HSA-3214847;Reactome: R-HSA-9616222;Reactome: R-HSA-5625886;Reactome: R-HSA-171306;Reactome: R-HSA-9610379;Reactome: R-HSA-73772;Reactome: R-HSA-2559586;Reactome: R-HSA-3214815;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-3214858;Reactome: R-HSA-5693571;Reactome: R-HSA-8939236;Reactome: R-HSA-5334118;Reactome: R-HSA-73728;Reactome: R-HSA-5693607;Reactome: R-HSA-5578749;Reactome: R-HSA-8936459	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Oxidative Stress Induced Senescence";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected purine";"Condensation of Prophase Chromosomes";"Cleavage of the damaged purine";"HCMV Early Events";"Senescence-Associated Secretory Phenotype (SASP)";"PRC2 methylates histones and DNA";"B-WICH complex positively regulates rRNA expression";"Meiotic recombination";"Pre-NOTCH Transcription and Translation";"Estrogen-dependent gene expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"Meiotic synapsis";"SIRT1 negatively regulates rRNA expression";"Amyloid fiber formation";"NoRC negatively regulates rRNA expression";"SUMOylation of chromatin organization proteins";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines";"HATs acetylate histones";"Transcriptional regulation of granulopoiesis";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Packaging Of Telomere Ends";"HCMV Late Events";"RNA Polymerase I Promoter Escape";"DNA Damage/Telomere Stress Induced Senescence";"HDACs deacetylate histones";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"RMTs methylate histone arginines";"Nonhomologous End-Joining (NHEJ)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"DNA methylation";"RNA Polymerase I Promoter Opening";"Processing of DNA double-strand break ends";"Transcriptional regulation by small RNAs";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Mdes011495-RB	7	Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.17;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.15;MetaCyc: PWY-5188;KEGG: 00860+6.1.1.17;Reactome: R-HSA-6782315	"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"tRNA modification in the nucleus and cytosol"
Mdes000370-RA	1	Reactome: R-HSA-114608	"Platelet degranulation"
Mdes001541-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-196843	"HATs acetylate histones";"Vitamin B2 (riboflavin) metabolism"
Mdes002040-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
Mdes019208-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes013626-RA	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
Mdes007668-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Mdes018011-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes007428-RE	3	Reactome: R-HSA-8868766;Reactome: R-HSA-6785470;Reactome: R-HSA-6784531	"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion";"tRNA processing in the nucleus"
Mdes005389-RA	4	Reactome: R-HSA-70263;KEGG: 00010+3.1.3.9;KEGG: 00052+3.1.3.9;KEGG: 00500+3.1.3.9	"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Galactose metabolism";"Starch and sucrose metabolism"
Mdes007328-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes003808-RA	1	Reactome: R-HSA-196741	"Cobalamin (Cbl, vitamin B12) transport and metabolism"
Mdes000977-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes010978-RA	5	KEGG: 00561+2.3.1.20;Reactome: R-HSA-1482883;Reactome: R-HSA-6798695;KEGG: 00073+2.3.1.20;Reactome: R-HSA-75109	"Glycerolipid metabolism";"Acyl chain remodeling of DAG and TAG";"Neutrophil degranulation";"Cutin, suberine and wax biosynthesis";"Triglyceride biosynthesis"
Mdes010085-RB	11	Reactome: R-HSA-1368082;Reactome: R-HSA-381340;Reactome: R-HSA-400206;Reactome: R-HSA-2151201;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-383280;Reactome: R-HSA-1368108;Reactome: R-HSA-2426168;Reactome: R-HSA-212436;Reactome: R-HSA-400253	"RORA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Regulation of lipid metabolism by PPARalpha";"Transcriptional activation of mitochondrial biogenesis";"Estrogen-dependent gene expression";"PPARA activates gene expression";"Nuclear Receptor transcription pathway";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of gene expression by SREBF (SREBP)";"Generic Transcription Pathway";"Circadian Clock"
Mdes004310-RB	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Mdes000464-RA	13	Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902	"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation"
Mdes002042-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
Mdes001240-RA	8	Reactome: R-HSA-70171;KEGG: 00520+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1	"Glycolysis";"Amino sugar and nucleotide sugar metabolism";"Neomycin, kanamycin and gentamicin biosynthesis";"Galactose metabolism";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis"
Mdes015093-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes008271-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes000888-RB	5	Reactome: R-HSA-5205685;Reactome: R-HSA-977225;Reactome: R-HSA-9646399;Reactome: R-HSA-983168;Reactome: R-HSA-5689877	"Pink/Parkin Mediated Mitophagy";"Amyloid fiber formation";"Aggrephagy";"Antigen processing: Ubiquitination & Proteasome degradation";"Josephin domain DUBs"
Mdes007420-RA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
Mdes014899-RA	5	MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22	"Stachyose degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism";"Glycerolipid metabolism"
Mdes008754-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes010661-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes003033-RA	11	Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-5689880;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-3214847;Reactome: R-HSA-167172;Reactome: R-HSA-76042	"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Ub-specific processing proteases";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HATs acetylate histones";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance"
Mdes001410-RA	2	MetaCyc: PWY-7851;KEGG: 00770+2.7.1.24	"Coenzyme A biosynthesis II (eukaryotic)";"Pantothenate and CoA biosynthesis"
Mdes002781-RA	2	Reactome: R-HSA-399719;Reactome: R-HSA-190873	"Trafficking of AMPA receptors";"Gap junction degradation"
Mdes017599-RA	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
Mdes001800-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes009647-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes013679-RA	14	MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199	"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation"
Mdes000985-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Mdes004021-RA	7	Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912	"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane"
Mdes002954-RA	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
Mdes003288-RA	4	Reactome: R-HSA-912631;Reactome: R-HSA-8875555;Reactome: R-HSA-8875656;Reactome: R-HSA-186763	"Regulation of signaling by CBL";"MET activates RAP1 and RAC1";"MET receptor recycling";"Downstream signal transduction"
Mdes004877-RA	2	Reactome: R-HSA-5673001;Reactome: R-HSA-8853659	"RAF/MAP kinase cascade";"RET signaling"
Mdes004123-RA	56	Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5668541;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-174154;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-187577;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837	"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"TNFR2 non-canonical NF-kB pathway";"Neddylation";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdc20 mediated degradation of Securin";"Ub-specific processing proteases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"SCF(Skp2)-mediated degradation of p27/p21";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation"
Mdes016905-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes012753-RA	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
Mdes005122-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Mdes007704-RA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Mdes000852-RA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
Mdes008063-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes018109-RA	3	MetaCyc: PWY-6986;Reactome: R-HSA-2022923;KEGG: 00051+4.2.2.3	"Alginate degradation";"Dermatan sulfate biosynthesis";"Fructose and mannose metabolism"
Mdes011210-RC	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Mdes000519-RB	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes006592-RA	3	Reactome: R-HSA-2024096;KEGG: 00531+3.2.1.50;Reactome: R-HSA-2206282	"HS-GAG degradation";"Glycosaminoglycan degradation";"MPS IIIB - Sanfilippo syndrome B"
Mdes007176-RA	4	Reactome: R-HSA-8849175;MetaCyc: PWY-6482;Reactome: R-HSA-5358493;MetaCyc: PWY-7546	"Threonine catabolism";"Diphthamide biosynthesis I (archaea)";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)"
Mdes001909-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes014278-RA	5	Reactome: R-HSA-2132295;Reactome: R-HSA-1655829;Reactome: R-HSA-5694530;Reactome: R-HSA-983170;Reactome: R-HSA-204005	"MHC class II antigen presentation";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"COPII-mediated vesicle transport"
Mdes002009-RA	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
Mdes011386-RA	17	Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-8953750;Reactome: R-HSA-111448;Reactome: R-HSA-69231;Reactome: R-HSA-1362277;Reactome: R-HSA-9616222;Reactome: R-HSA-113501;Reactome: R-HSA-2559580;Reactome: R-HSA-6804114;Reactome: R-HSA-139915;Reactome: R-HSA-2173796;Reactome: R-HSA-69205;Reactome: R-HSA-1362300;Reactome: R-HSA-1912408;Reactome: R-HSA-1538133;Reactome: R-HSA-2559585	"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"Transcriptional Regulation by E2F6";"Activation of NOXA and translocation to mitochondria";"Cyclin D associated events in G1";"Transcription of E2F targets under negative control by DREAM complex";"Transcriptional regulation of granulopoiesis";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Oxidative Stress Induced Senescence";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Activation of PUMA and translocation to mitochondria";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Pre-NOTCH Transcription and Translation";"G0 and Early G1";"Oncogene Induced Senescence"
Mdes009048-RA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"Neutrophil degranulation";"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes002420-RA	9	Reactome: R-HSA-198323;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1	"AKT phosphorylates targets in the cytosol";"mTOR signaling pathway";"Constitutive Signaling by AKT1 E17K in Cancer";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway"
Mdes007491-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes005027-RA	6	MetaCyc: PWY-6737;KEGG: 00500+2.4.1.1;MetaCyc: PWY-6731;MetaCyc: PWY-5941;Reactome: R-HSA-70221;MetaCyc: PWY-7238	"Starch degradation V";"Starch and sucrose metabolism";"Starch degradation III";"Glycogen degradation II";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II"
Mdes002079-RB	3	Reactome: R-HSA-71336;KEGG: 00030+1.1.1.44;KEGG: 00480+1.1.1.44	"Pentose phosphate pathway";"Pentose phosphate pathway";"Glutathione metabolism"
Mdes018579-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Mdes016395-RA	12	Reactome: R-HSA-9648025;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-141444	"EML4 and NUDC in mitotic spindle formation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
Mdes009974-RB	3	Reactome: R-HSA-877300;Reactome: R-HSA-909733;Reactome: R-HSA-8983711	"Interferon gamma signaling";"Interferon alpha/beta signaling";"OAS antiviral response"
Mdes017124-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes000312-RE	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Mdes004210-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Mdes000798-RA	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
Mdes010242-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Mdes010509-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Mdes000213-RC	6	Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress"
Mdes011976-RA	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
Mdes016636-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Mdes008201-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes014126-RA	10	KEGG: 00052+5.1.3.2;MetaCyc: PWY-6397;MetaCyc: PWY-6317;Reactome: R-HSA-70370;Reactome: R-HSA-5609977;MetaCyc: PWY-3821;MetaCyc: PWY-7328;KEGG: 00520+5.1.3.2;MetaCyc: PWY-7344;MetaCyc: PWY-6527	"Galactose metabolism";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose degradation I (Leloir pathway)";"Galactose catabolism";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose detoxification";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Amino sugar and nucleotide sugar metabolism";"UDP-alpha-D-galactose biosynthesis";"Stachyose degradation"
Mdes002321-RA	1	Reactome: R-HSA-6783984	"Glycine degradation"
Mdes014323-RA	3	Reactome: R-HSA-192456;KEGG: 00561+3.1.1.3;MetaCyc: PWY-6857	"Digestion of dietary lipid";"Glycerolipid metabolism";"Retinol biosynthesis"
Mdes018074-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Mdes017067-RA	5	KEGG: 00760+6.3.4.21;Reactome: R-HSA-197264;Reactome: R-HSA-6798695;MetaCyc: PWY-5381;Reactome: R-HSA-1368108	"Nicotinate and nicotinamide metabolism";"Nicotinamide salvaging";"Neutrophil degranulation";"Pyridine nucleotide cycling (plants)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression"
Mdes016572-RB	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Mdes000375-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes006626-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Mdes000108-RA	6	Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156827	"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression"
Mdes015930-RA	7	MetaCyc: PWY-5461;MetaCyc: PWY-7445;MetaCyc: PWY-7214;MetaCyc: PWY-5466;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5469;MetaCyc: PWY-6824	"Betanidin degradation";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Matairesinol biosynthesis";"Phenylpropanoid biosynthesis";"Sesamin biosynthesis";"Justicidin B biosynthesis"
Mdes009430-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes011729-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes004661-RA	5	Reactome: R-HSA-8951664;Reactome: R-HSA-5689603;Reactome: R-HSA-917937;Reactome: R-HSA-8856825;Reactome: R-HSA-2173789	"Neddylation";"UCH proteinases";"Iron uptake and transport";"Cargo recognition for clathrin-mediated endocytosis";"TGF-beta receptor signaling activates SMADs"
Mdes015108-RA	3	Reactome: R-HSA-159230;Reactome: R-HSA-77588;Reactome: R-HSA-73856	"Transport of the SLBP Dependant Mature mRNA";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination"
Mdes008752-RA	15	Reactome: R-HSA-167238;Reactome: R-HSA-2173796;Reactome: R-HSA-167200;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-176034;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-9018519;Reactome: R-HSA-6807505;Reactome: R-HSA-167152	"Pausing and recovery of Tat-mediated HIV elongation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Interactions of Tat with host cellular proteins";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Estrogen-dependent gene expression";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat"
Mdes006220-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes005681-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes000142-RB	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Mdes002207-RA	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis"
Mdes011880-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes012268-RA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes018644-RA	1	Reactome: R-HSA-74217	"Purine salvage"
Mdes008668-RA	13	KEGG: 00053+1.8.5.1;MetaCyc: PWY-4061;MetaCyc: PWY-6370;Reactome: R-HSA-196836;MetaCyc: PWY-2261;KEGG: 00480+2.5.1.18+1.8.5.1;Reactome: R-HSA-156590;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7112;MetaCyc: PWY-7533;KEGG: 00983+2.5.1.18;KEGG: 00980+2.5.1.18;MetaCyc: PWY-6842	"Ascorbate and aldarate metabolism";"Glutathione-mediated detoxification I";"Ascorbate recycling (cytosolic)";"Vitamin C (ascorbate) metabolism";"Ascorbate glutathione cycle";"Glutathione metabolism";"Glutathione conjugation";"Drug metabolism - cytochrome P450";"4-hydroxy-2-nonenal detoxification";"Gliotoxin biosynthesis";"Drug metabolism - other enzymes";"Metabolism of xenobiotics by cytochrome P450";"Glutathione-mediated detoxification II"
Mdes018342-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes016197-RA	16	Reactome: R-HSA-975155;Reactome: R-HSA-9020702;Reactome: R-HSA-209543;Reactome: R-HSA-5602680;Reactome: R-HSA-6811558;Reactome: R-HSA-5603037;Reactome: R-HSA-3134963;Reactome: R-HSA-5603041;Reactome: R-HSA-975138;Reactome: R-HSA-5602498;Reactome: R-HSA-166058;Reactome: R-HSA-1257604;Reactome: R-HSA-1236974;Reactome: R-HSA-975110;Reactome: R-HSA-1810476;Reactome: R-HSA-975871	"MyD88 dependent cascade initiated on endosome";"Interleukin-1 signaling";"p75NTR recruits signalling complexes";"MyD88 deficiency (TLR5)";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"IRAK4 deficiency (TLR5)";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"IRAK4 deficiency (TLR2/4)";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"MyD88 deficiency (TLR2/4)";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"PIP3 activates AKT signaling";"ER-Phagosome pathway";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"RIP-mediated NFkB activation via ZBP1";"MyD88 cascade initiated on plasma membrane"
Mdes017907-RA	1	Reactome: R-HSA-71288	"Creatine metabolism"
Mdes001466-RA	5	Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-5625740;Reactome: R-HSA-75035;Reactome: R-HSA-5628897	"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate PKNs";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes"
Mdes009802-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902	"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation"
Mdes006220-RB	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes015883-RA	10	KEGG: 00430+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-7112;MetaCyc: PWY-5826;KEGG: 00460+2.3.2.2;MetaCyc: PWY-7559;MetaCyc: PWY-6842;MetaCyc: PWY-4041	"Taurine and hypotaurine metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Glutathione metabolism";"4-hydroxy-2-nonenal detoxification";"Hypoglycin biosynthesis";"Cyanoamino acid metabolism";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II";"Gamma-glutamyl cycle"
Mdes007568-RA	24	Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-9648025;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-8852276;Reactome: R-HSA-6811434;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-2467813;Reactome: R-HSA-190840;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-5626467;Reactome: R-HSA-9609736;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-8955332	"Mitotic Prometaphase";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Gap junction assembly";"EML4 and NUDC in mitotic spindle formation";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Cilium Assembly";"COPI-mediated anterograde transport";"Kinesins";"Separation of Sister Chromatids";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases activate IQGAPs";"Assembly and cell surface presentation of NMDA receptors";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin"
Mdes004498-RA	17	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6790901;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"rRNA modification in the nucleus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition"
Mdes001694-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes017649-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes006656-RA	9	Reactome: R-HSA-69205;Reactome: R-HSA-68962;Reactome: R-HSA-174430;Reactome: R-HSA-69166;Reactome: R-HSA-174411;Reactome: R-HSA-68952;Reactome: R-HSA-113501;Reactome: R-HSA-69091;Reactome: R-HSA-69183	"G1/S-Specific Transcription";"Activation of the pre-replicative complex";"Telomere C-strand synthesis initiation";"Removal of the Flap Intermediate";"Polymerase switching on the C-strand of the telomere";"DNA replication initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Polymerase switching";"Processive synthesis on the lagging strand"
Mdes004004-RA	1	Reactome: R-HSA-2465910	"MASTL Facilitates Mitotic Progression"
Mdes000254-RC	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
Mdes003655-RA	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
Mdes000231-RA	5	Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387	"Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling"
Mdes005911-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes007689-RA	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
Mdes015043-RA	2	Reactome: R-HSA-418594;Reactome: R-HSA-375276	"G alpha (i) signalling events";"Peptide ligand-binding receptors"
Mdes012210-RB	16	MetaCyc: PWY-7003;Reactome: R-HSA-70171;MetaCyc: PWY-1042;MetaCyc: PWY-5484;MetaCyc: PWY-5723;MetaCyc: PWY-7218;Reactome: R-HSA-70263;MetaCyc: PWY-6142;MetaCyc: PWY-2221;MetaCyc: PWY-6901;MetaCyc: PWY-6886;MetaCyc: PWY-1622;MetaCyc: PWY-8004;KEGG: 00010+4.2.1.11;MetaCyc: PWY-7124;KEGG: 00680+4.2.1.11	"Glycerol degradation to butanol";"Glycolysis";"Glycolysis IV (plant cytosol)";"Glycolysis II (from fructose 6-phosphate)";"Rubisco shunt";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Gluconeogenesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Superpathway of glucose and xylose degradation";"1-butanol autotrophic biosynthesis (engineered)";"Formaldehyde assimilation I (serine pathway)";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Ethylene biosynthesis V (engineered)";"Methane metabolism"
Mdes005212-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Mdes001710-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection"
Mdes010385-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes009006-RA	6	Reactome: R-HSA-5693568;Reactome: R-HSA-912446;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic recombination";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
Mdes009269-RA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
Mdes001501-RA	5	KEGG: 00020+4.2.1.3;KEGG: 00290+4.2.1.33;KEGG: 00630+4.2.1.3;Reactome: R-HSA-917937;KEGG: 00720+4.2.1.3	"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine biosynthesis";"Glyoxylate and dicarboxylate metabolism";"Iron uptake and transport";"Carbon fixation pathways in prokaryotes"
Mdes008923-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes000119-RA	3	Reactome: R-HSA-1660514;Reactome: R-HSA-1660517;Reactome: R-HSA-1660516	"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the late endosome membrane";"Synthesis of PIPs at the early endosome membrane"
Mdes013573-RA	4	Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862	"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
Mdes000079-RA	7	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
Mdes014691-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes003681-RA	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
Mdes000335-RA	4	Reactome: R-HSA-446193;KEGG: 00513+2.4.1.260;KEGG: 00510+2.4.1.260;Reactome: R-HSA-4720489	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective ALG12 causes ALG12-CDG (CDG-1g)"
Mdes000733-RA	1	Reactome: R-HSA-8953750	"Transcriptional Regulation by E2F6"
Mdes003514-RA	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
Mdes006984-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes011300-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
Mdes006431-RA	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
Mdes003536-RA	5	Reactome: R-HSA-499943;MetaCyc: PWY-7185;KEGG: 00240+6.3.4.2;MetaCyc: PWY-7177;MetaCyc: PWY-7176	"Interconversion of nucleotide di- and triphosphates";"UTP and CTP dephosphorylation I";"Pyrimidine metabolism";"UTP and CTP dephosphorylation II";"UTP and CTP de novo biosynthesis"
Mdes017958-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes001740-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Mdes003973-RA	57	Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-5668541;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-5362768;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-187577;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-180534;Reactome: R-HSA-174154;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-6798695;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764	"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"TNFR2 non-canonical NF-kB pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"SCF(Skp2)-mediated degradation of p27/p21";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Vpu mediated degradation of CD4";"APC/C:Cdc20 mediated degradation of Securin";"Ub-specific processing proteases";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"Neutrophil degranulation";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling"
Mdes015115-RA	16	Reactome: R-HSA-2219530;Reactome: R-HSA-9664565;Reactome: R-HSA-1251985;Reactome: R-HSA-5673001;Reactome: R-HSA-1250347;Reactome: R-HSA-6811558;Reactome: R-HSA-8863795;Reactome: R-HSA-1963640;Reactome: R-HSA-1227986;Reactome: R-HSA-1250196;Reactome: R-HSA-1250342;Reactome: R-HSA-1236394;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993;Reactome: R-HSA-6785631;Reactome: R-HSA-1963642	"Constitutive Signaling by Aberrant PI3K in Cancer";"Signaling by ERBB2 KD Mutants";"Nuclear signaling by ERBB4";"RAF/MAP kinase cascade";"SHC1 events in ERBB4 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downregulation of ERBB2 signaling";"GRB2 events in ERBB2 signaling";"Signaling by ERBB2";"SHC1 events in ERBB2 signaling";"PI3K events in ERBB4 signaling";"Signaling by ERBB4";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling";"ERBB2 Regulates Cell Motility";"PI3K events in ERBB2 signaling"
Mdes007597-RC	16	Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-2408557;Reactome: R-HSA-72695	"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex"
Mdes006618-RA	4	Reactome: R-HSA-176187;Reactome: R-HSA-69205;Reactome: R-HSA-68962;Reactome: R-HSA-176974	"Activation of ATR in response to replication stress";"G1/S-Specific Transcription";"Activation of the pre-replicative complex";"Unwinding of DNA"
Mdes003441-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Mdes008177-RA	6	Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450385	"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes010834-RA	4	KEGG: 00760+6.3.4.21;Reactome: R-HSA-6798695;MetaCyc: PWY-5381;Reactome: R-HSA-197264	"Nicotinate and nicotinamide metabolism";"Neutrophil degranulation";"Pyridine nucleotide cycling (plants)";"Nicotinamide salvaging"
Mdes003272-RA	6	Reactome: R-HSA-6814122;Reactome: R-HSA-5620922;Reactome: R-HSA-390450;Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-390471	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"BBSome-mediated cargo-targeting to cilium";"Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis"
Mdes007441-RA	1	Reactome: R-HSA-1483255	"PI Metabolism"
Mdes003038-RB	5	KEGG: 00564+2.7.7.41;MetaCyc: PWY-5667;MetaCyc: PWY-5981;KEGG: 04070+2.7.7.41;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)"
Mdes002260-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Mdes004097-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Mdes001278-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
Mdes017526-RA	4	Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.6;Reactome: R-HSA-379716;Reactome: R-HSA-379726	"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Mitochondrial tRNA aminoacylation"
Mdes004426-RB	10	KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348;Reactome: R-HSA-76071;Reactome: R-HSA-76066;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-73780;KEGG: 00740+3.1.3.2;Reactome: R-HSA-76061;Reactome: R-HSA-749476	"Thiamine metabolism";"Phosphate acquisition";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"Riboflavin metabolism";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
Mdes008451-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Mdes004034-RA	5	Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-917977	"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Ion channel transport";"Transferrin endocytosis and recycling"
Mdes006614-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes004988-RC	4	Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
Mdes015764-RA	2	Reactome: R-HSA-389661;Reactome: R-HSA-9033241	"Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import"
Mdes004595-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Mdes004370-RB	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes002724-RA	14	MetaCyc: PWY-7118;MetaCyc: PWY-5133;KEGG: 00630+6.2.1.1;MetaCyc: PWY-5132;MetaCyc: PWY-7857;Reactome: R-HSA-389661;KEGG: 00720+6.2.1.1;KEGG: 00640+6.2.1.1;Reactome: R-HSA-6783984;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5108;MetaCyc: PWY-6672;KEGG: 00010+6.2.1.1;KEGG: 00620+6.2.1.1	"Chitin degradation to ethanol";"Colupulone and cohumulone biosynthesis";"Glyoxylate and dicarboxylate metabolism";"Lupulone and humulone biosynthesis";"Adlupulone and adhumulone biosynthesis";"Glyoxylate metabolism and glycine degradation";"Carbon fixation pathways in prokaryotes";"Propanoate metabolism";"Glycine degradation";"Methane metabolism";"L-isoleucine biosynthesis V";"Cis-genanyl-coa degradation";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism"
Mdes016651-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes004884-RB	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
Mdes000414-RB	3	Reactome: R-HSA-418594;Reactome: R-HSA-375276;Reactome: R-HSA-416476	"G alpha (i) signalling events";"Peptide ligand-binding receptors";"G alpha (q) signalling events"
Mdes006368-RB	12	Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-381038;Reactome: R-HSA-5620912;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-8854518	"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"XBP1(S) activates chaperone genes";"Anchoring of the basal body to the plasma membrane";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2"
Mdes000350-RA	7	Reactome: R-HSA-389661;KEGG: 00020+2.3.1.61;MetaCyc: PWY-5084;Reactome: R-HSA-71403;KEGG: 00310+2.3.1.61;KEGG: 00380+2.3.1.61;Reactome: R-HSA-71064	"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Citric acid cycle (TCA cycle)";"Lysine degradation";"Tryptophan metabolism";"Lysine catabolism"
Mdes012842-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes007708-RA	9	KEGG: 00562+3.1.4.11;Reactome: R-HSA-416476;MetaCyc: PWY-8052;MetaCyc: PWY-7039;MetaCyc: PWY-6351;Reactome: R-HSA-1855204;Reactome: R-HSA-112043;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367	"Inositol phosphate metabolism";"G alpha (q) signalling events";"2-arachidonoylglycerol biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"PLC beta mediated events";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism"
Mdes005055-RA	7	Reactome: R-HSA-2644606;MetaCyc: PWY-7511;Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Protein ubiquitination";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
Mdes015464-RA	3	Reactome: R-HSA-3928662;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
Mdes002499-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes004062-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes011304-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5689880	"UCH proteinases";"Ub-specific processing proteases"
Mdes011833-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Mdes004566-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes002141-RA	6	Reactome: R-HSA-1650814;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-2022090	"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization";"Collagen degradation";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Assembly of collagen fibrils and other multimeric structures"
Mdes008917-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes004684-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes005081-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes004200-RA	8	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Signaling by Hippo";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection"
Mdes008587-RC	2	Reactome: R-HSA-8949215;Reactome: R-HSA-983231	"Mitochondrial calcium ion transport";"Factors involved in megakaryocyte development and platelet production"
Mdes014864-RA	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
Mdes008413-RD	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes017753-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes008280-RA	27	Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-3108214;Reactome: R-HSA-159230;Reactome: R-HSA-168276	"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways"
Mdes008374-RA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
Mdes010153-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes004686-RB	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
Mdes014658-RA	8	MetaCyc: PWY-241;MetaCyc: PWY-5789;MetaCyc: PWY-7115;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-5743	"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"3-hydroxypropanoate cycle"
Mdes012040-RA	2	Reactome: R-HSA-72706;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition"
Mdes000877-RA	9	KEGG: 00564+1.1.1.94;MetaCyc: PWY-5667;Reactome: R-HSA-1483166;MetaCyc: PWY-5981;KEGG: 00564+1.1.1.8;MetaCyc: PWY-7902;MetaCyc: PWY-6118;MetaCyc: PWY-7411;MetaCyc: PWY-7385	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism";"Glucosylglycerol biosynthesis";"Glycerol-3-phosphate shuttle";"Phosphatidate biosynthesis (yeast)";"1,3-propanediol biosynthesis (engineered)"
Mdes020091-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes004102-RB	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes006272-RA	8	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;MetaCyc: PWY-5668;MetaCyc: PWY-7817;Reactome: R-HSA-1483148;KEGG: 04658+3.1.3.16;MetaCyc: PWY-5269;KEGG: 00564+3.1.3.27	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Cardiolipin biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Synthesis of PG";"Th1 and Th2 cell differentiation";"Cardiolipin biosynthesis II";"Glycerophospholipid metabolism"
Mdes006291-RA	1	Reactome: R-HSA-427413	"NoRC negatively regulates rRNA expression"
Mdes015548-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes004687-RA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-390918	"Peroxisomal protein import";"Peroxisomal lipid metabolism"
Mdes009855-RA	2	Reactome: R-HSA-1483152;Reactome: R-HSA-1483115	"Hydrolysis of LPE";"Hydrolysis of LPC"
Mdes014171-RA	4	Reactome: R-HSA-1483191;KEGG: 00564+3.1.1.7;Reactome: R-HSA-422085;Reactome: R-HSA-112311	"Synthesis of PC";"Glycerophospholipid metabolism";"Synthesis, secretion, and deacylation of Ghrelin";"Neurotransmitter clearance"
Mdes018669-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes006885-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes007548-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes015490-RA	7	KEGG: 00940+1.11.1.7;MetaCyc: PWY-5469;MetaCyc: PWY-6824;MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-7445;MetaCyc: PWY-5461	"Phenylpropanoid biosynthesis";"Sesamin biosynthesis";"Justicidin B biosynthesis";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Luteolin triglucuronide degradation";"Betanidin degradation"
Mdes007468-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes016559-RA	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
Mdes009312-RA	12	MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7417;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;MetaCyc: PWY-6803	"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Ether lipid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing"
Mdes005494-RA	4	Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Mdes009521-RA	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
Mdes001779-RA	18	Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-446193;Reactome: R-HSA-72649;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;KEGG: 00510+2.4.1.256	"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Translation initiation complex formation";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"N-Glycan biosynthesis"
Mdes008183-RA	1	Reactome: R-HSA-5683826	"Surfactant metabolism"
Mdes003277-RB	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2122947	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription"
Mdes019877-RA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
Mdes010651-RA	16	Reactome: R-HSA-5693548;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693571;Reactome: R-HSA-5693607;Reactome: R-HSA-9018519;Reactome: R-HSA-5693554;Reactome: R-HSA-2559586;Reactome: R-HSA-201722;Reactome: R-HSA-5693616;Reactome: R-HSA-3214847;Reactome: R-HSA-5693565	"Sensing of DNA Double Strand Breaks";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Nonhomologous End-Joining (NHEJ)";"Processing of DNA double-strand break ends";"Estrogen-dependent gene expression";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"DNA Damage/Telomere Stress Induced Senescence";"Formation of the beta-catenin:TCF transactivating complex";"Presynaptic phase of homologous DNA pairing and strand exchange";"HATs acetylate histones";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
Mdes017614-RA	5	KEGG: 00940+1.11.1.21;KEGG: 00380+1.11.1.21;KEGG: 00983+1.11.1.21;KEGG: 00360+1.11.1.21;MetaCyc: PWY-5506	"Phenylpropanoid biosynthesis";"Tryptophan metabolism";"Drug metabolism - other enzymes";"Phenylalanine metabolism";"Methanol oxidation to formaldehyde IV"
Mdes019629-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes000657-RB	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes004568-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes004462-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes009136-RA	6	MetaCyc: PWY-6983;KEGG: 00790+4.2.3.12;MetaCyc: PWY-7442;MetaCyc: PWY-5664;Reactome: R-HSA-1474151;MetaCyc: PWY-5663	"Threo-tetrahydrobiopterin biosynthesis";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis II";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis I"
Mdes008886-RB	2	KEGG: 00071+2.3.1.21;MetaCyc: PWY-6111	"Fatty acid degradation";"Mitochondrial L-carnitine shuttle"
Mdes015341-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes010522-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes015925-RA	10	MetaCyc: PWY-5826;MetaCyc: PWY-7112;KEGG: 00460+2.3.2.2;MetaCyc: PWY-6842;MetaCyc: PWY-7559;MetaCyc: PWY-4041;KEGG: 00430+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13	"Hypoglycin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Cyanoamino acid metabolism";"Glutathione-mediated detoxification II";"Glutathione degradation (DUG pathway";"Gamma-glutamyl cycle";"Taurine and hypotaurine metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Glutathione metabolism"
Mdes001249-RA	14	Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-426486;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-203927;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-1912408;Reactome: R-HSA-426496;Reactome: R-HSA-9029569	"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"Small interfering RNA (siRNA) biogenesis";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MicroRNA (miRNA) biogenesis";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Pre-NOTCH Transcription and Translation";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
Mdes010105-RB	2	Reactome: R-HSA-975957;Reactome: R-HSA-975956	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
Mdes010131-RA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
Mdes014447-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes008794-RA	1	Reactome: R-HSA-2428928	"IRS-related events triggered by IGF1R"
Mdes006027-RA	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
Mdes009854-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes002285-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes006670-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Mdes014982-RA	4	MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-6483	"Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide degradation (generic)"
Mdes018482-RA	3	MetaCyc: PWY-7400;MetaCyc: PWY-5154;KEGG: 00220+1.2.1.38	"L-arginine biosynthesis IV (archaebacteria)";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Arginine biosynthesis"
Mdes005809-RB	3	Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807	"Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism"
Mdes007134-RA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
Mdes001847-RB	9	Reactome: R-HSA-194840;Reactome: R-HSA-5218920;Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-2871796;Reactome: R-HSA-114604;Reactome: R-HSA-4420097;Reactome: R-HSA-2871809;Reactome: R-HSA-2029482	"Rho GTPase cycle";"VEGFR2 mediated vascular permeability";"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"FCERI mediated MAPK activation";"GPVI-mediated activation cascade";"VEGFA-VEGFR2 Pathway";"FCERI mediated Ca+2 mobilization";"Regulation of actin dynamics for phagocytic cup formation"
Mdes019580-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes005369-RC	2	Reactome: R-HSA-204174;Reactome: R-HSA-5362517	"Regulation of pyruvate dehydrogenase (PDH) complex";"Signaling by Retinoic Acid"
Mdes009568-RA	3	Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154	"Smooth Muscle Contraction";"Purine metabolism";"Nitric oxide stimulates guanylate cyclase"
Mdes004869-RE	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Mdes002959-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Mdes005054-RA	4	Reactome: R-HSA-75153;MetaCyc: PWY-7285;MetaCyc: PWY-7286;MetaCyc: PWY-6829	"Apoptotic execution phase";"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Trna methylation (yeast)"
Mdes017264-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Mdes002988-RA	9	Reactome: R-HSA-68616;Reactome: R-HSA-68962;Reactome: R-HSA-69205;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68689	"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex";"G1/S-Specific Transcription";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"CDC6 association with the ORC:origin complex"
Mdes009102-RA	3	Reactome: R-HSA-194840;Reactome: R-HSA-193648;Reactome: R-HSA-416482	"Rho GTPase cycle";"NRAGE signals death through JNK";"G alpha (12/13) signalling events"
Mdes018321-RA	4	MetaCyc: PWY-5704;KEGG: 00791+3.5.1.5;KEGG: 00230+3.5.1.5;KEGG: 00220+3.5.1.5	"Urea degradation II";"Atrazine degradation";"Purine metabolism";"Arginine biosynthesis"
Mdes019627-RA	1	Reactome: R-HSA-71262	"Carnitine synthesis"
Mdes002409-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes003538-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes001071-RA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Mdes010824-RA	4	KEGG: 00270+4.2.1.22;MetaCyc: PWY-801;KEGG: 00260+4.2.1.22;Reactome: R-HSA-1614603	"Cysteine and methionine metabolism";"Homocysteine and cysteine interconversion";"Glycine, serine and threonine metabolism";"Cysteine formation from homocysteine"
Mdes016061-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
Mdes015498-RA	13	MetaCyc: PWY-7226;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-7222;MetaCyc: PWY-7227;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7184;KEGG: 00480+1.17.4.1;Reactome: R-HSA-499943;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7210;MetaCyc: PWY-6545	"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Interconversion of nucleotide di- and triphosphates";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis III"
Mdes006118-RE	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
Mdes014417-RA	42	Reactome: R-HSA-3214841;Reactome: R-HSA-3214847;Reactome: R-HSA-427389;Reactome: R-HSA-201722;Reactome: R-HSA-9610379;Reactome: R-HSA-2559586;Reactome: R-HSA-73772;Reactome: R-HSA-3214815;Reactome: R-HSA-9616222;Reactome: R-HSA-5625886;Reactome: R-HSA-171306;Reactome: R-HSA-8939236;Reactome: R-HSA-5693607;Reactome: R-HSA-5334118;Reactome: R-HSA-73728;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-3214858;Reactome: R-HSA-5693571;Reactome: R-HSA-8936459;Reactome: R-HSA-5578749;Reactome: R-HSA-2559580;Reactome: R-HSA-5693565;Reactome: R-HSA-110328;Reactome: R-HSA-5617472;Reactome: R-HSA-2299718;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-110330;Reactome: R-HSA-212300;Reactome: R-HSA-5250924;Reactome: R-HSA-912446;Reactome: R-HSA-1912408;Reactome: R-HSA-9018519;Reactome: R-HSA-606279;Reactome: R-HSA-1221632;Reactome: R-HSA-9609690;Reactome: R-HSA-2559582;Reactome: R-HSA-977225;Reactome: R-HSA-427413;Reactome: R-HSA-4551638;Reactome: R-HSA-427359	"PKMTs methylate histone lysines";"HATs acetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Formation of the beta-catenin:TCF transactivating complex";"HCMV Late Events";"DNA Damage/Telomere Stress Induced Senescence";"RNA Polymerase I Promoter Escape";"HDACs deacetylate histones";"Transcriptional regulation of granulopoiesis";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Packaging Of Telomere Ends";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Processing of DNA double-strand break ends";"DNA methylation";"RNA Polymerase I Promoter Opening";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"RMTs methylate histone arginines";"Nonhomologous End-Joining (NHEJ)";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional regulation by small RNAs";"Oxidative Stress Induced Senescence";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Condensation of Prophase Chromosomes";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected purine";"PRC2 methylates histones and DNA";"B-WICH complex positively regulates rRNA expression";"Meiotic recombination";"Pre-NOTCH Transcription and Translation";"Estrogen-dependent gene expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"Meiotic synapsis";"HCMV Early Events";"Senescence-Associated Secretory Phenotype (SASP)";"Amyloid fiber formation";"NoRC negatively regulates rRNA expression";"SUMOylation of chromatin organization proteins";"SIRT1 negatively regulates rRNA expression"
Mdes014964-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes004547-RA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
Mdes005588-RA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
Mdes000435-RA	1	Reactome: R-HSA-446210	"Synthesis of UDP-N-acetyl-glucosamine"
Mdes002089-RA	9	Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-110330;Reactome: R-HSA-5649702;Reactome: R-HSA-110328;Reactome: R-HSA-9656255;Reactome: R-HSA-9656256;Reactome: R-HSA-9657050;Reactome: R-HSA-110357	"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected purine";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective OGG1 Substrate Binding";"Defective OGG1 Substrate Processing";"Defective OGG1 Localization";"Displacement of DNA glycosylase by APEX1"
Mdes007774-RC	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
Mdes003647-RA	13	Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane"
Mdes017010-RA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6798695;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"Neutrophil degranulation";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes008800-RA	13	Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression"
Mdes019871-RA	6	Reactome: R-HSA-8939902;MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-8863795;Reactome: R-HSA-8948751;Reactome: R-HSA-2173788	"Regulation of RUNX2 expression and activity";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Downregulation of ERBB2 signaling";"Regulation of PTEN stability and activity";"Downregulation of TGF-beta receptor signaling"
Mdes016932-RC	7	KEGG: 00051+3.1.3.11;KEGG: 00030+3.1.3.11;MetaCyc: PWY-5484;Reactome: R-HSA-70263;KEGG: 00010+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11	"Fructose and mannose metabolism";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)";"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Methane metabolism"
Mdes000871-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes002024-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes007200-RA	1	Reactome: R-HSA-264876	"Insulin processing"
Mdes007572-RA	3	Reactome: R-HSA-6794361;Reactome: R-HSA-6798695;Reactome: R-HSA-264870	"Neurexins and neuroligins";"Neutrophil degranulation";"Caspase-mediated cleavage of cytoskeletal proteins"
Mdes018884-RA	16	Reactome: R-HSA-5693565;Reactome: R-HSA-3214841;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-2559586;Reactome: R-HSA-5685939;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5685942;Reactome: R-HSA-5693548;Reactome: R-HSA-5685938;Reactome: R-HSA-5693568	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"PKMTs methylate histone lysines";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"DNA Damage/Telomere Stress Induced Senescence";"HDR through MMEJ (alt-NHEJ)";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"Meiotic recombination";"HDR through Homologous Recombination (HRR)";"Sensing of DNA Double Strand Breaks";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Mdes009717-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes011377-RA	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
Mdes005633-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Mdes006781-RA	10	MetaCyc: PWY-7199;KEGG: 00670+2.1.1.45;MetaCyc: PWY-7198;MetaCyc: PWY-7184;Reactome: R-HSA-499943;MetaCyc: PWY-3841;MetaCyc: PWY-7210;KEGG: 00240+2.1.1.45;MetaCyc: PWY-7187;Reactome: R-HSA-69205	"Pyrimidine deoxyribonucleosides salvage";"One carbon pool by folate";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Folate transformations II (plants)";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"G1/S-Specific Transcription"
Mdes003574-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Mdes006485-RC	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes007748-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes008189-RA	8	KEGG: 00790+1.14.16.2;KEGG: 00950+1.14.16.2;MetaCyc: PWY-5049;MetaCyc: PWY-6133;KEGG: 00350+1.14.16.2;MetaCyc: PWY-5394;Reactome: R-HSA-209905;MetaCyc: PWY-3581	"Folate biosynthesis";"Isoquinoline alkaloid biosynthesis";"Rosmarinic acid biosynthesis II";"(S)-reticuline biosynthesis II";"Tyrosine metabolism";"Betalamic acid biosynthesis";"Catecholamine biosynthesis";"(S)-reticuline biosynthesis I"
Mdes007414-RE	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes001851-RA	4	Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265	"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes"
Mdes012865-RB	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes007867-RA	2	KEGG: 00052+3.2.1.26;KEGG: 00500+3.2.1.26	"Galactose metabolism";"Starch and sucrose metabolism"
Mdes004837-RA	8	KEGG: 00010+1.1.1.27;Reactome: R-HSA-70268;MetaCyc: PWY-8086;KEGG: 00270+1.1.1.27;MetaCyc: PWY-5481;KEGG: 00640+1.1.1.27;MetaCyc: PWY-6901;KEGG: 00620+1.1.1.27	"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Cysteine and methionine metabolism";"Pyruvate fermentation to (S)-lactate";"Propanoate metabolism";"Superpathway of glucose and xylose degradation";"Pyruvate metabolism"
Mdes001667-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes006945-RC	13	Reactome: R-HSA-437239;Reactome: R-HSA-8866427;Reactome: R-HSA-5140745;Reactome: R-HSA-8856825;Reactome: R-HSA-167590;Reactome: R-HSA-5099900;Reactome: R-HSA-8964038;Reactome: R-HSA-177504;Reactome: R-HSA-2132295;Reactome: R-HSA-182218;Reactome: R-HSA-416993;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828	"Recycling pathway of L1";"VLDLR internalisation and degradation";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Cargo recognition for clathrin-mediated endocytosis";"Nef Mediated CD4 Down-regulation";"WNT5A-dependent internalization of FZD4";"LDL clearance";"Retrograde neurotrophin signalling";"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation";"Trafficking of GluR2-containing AMPA receptors";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis"
Mdes001780-RA	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
Mdes001241-RA	56	Reactome: R-HSA-174154;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-187577;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5668541;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442	"APC/C:Cdc20 mediated degradation of Securin";"Ub-specific processing proteases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Neddylation";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"TNFR2 non-canonical NF-kB pathway";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs"
Mdes006587-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes001727-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes019744-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes004985-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes000213-RD	6	Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68962	"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Switching of origins to a post-replicative state";"Unwinding of DNA";"Orc1 removal from chromatin";"Activation of the pre-replicative complex"
Mdes008483-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes009412-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes002213-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes006837-RB	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes009941-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes005295-RA	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Glycerolipid metabolism"
Mdes014983-RA	15	Reactome: R-HSA-2559580;Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-8936459;Reactome: R-HSA-8853884;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128	"Oxidative Stress Induced Senescence";"Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by VENTX";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling"
Mdes004220-RA	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
Mdes007029-RB	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes007565-RA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
Mdes017590-RA	2	MetaCyc: PWY-5316;MetaCyc: PWY-7342	"Nicotine biosynthesis";"Superpathway of nicotine biosynthesis"
Mdes008244-RB	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
Mdes012533-RA	5	MetaCyc: PWY-5523;MetaCyc: PWY-7863;KEGG: 00740+2.7.1.26;Reactome: R-HSA-196843;MetaCyc: PWY-6168	"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Roseoflavin biosynthesis";"Riboflavin metabolism";"Vitamin B2 (riboflavin) metabolism";"Flavin biosynthesis III (fungi)"
Mdes001673-RA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Mdes019970-RA	4	MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49;KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268	"Entner-Doudoroff pathway I";"Pentose phosphate pathway";"Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
Mdes014960-RA	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
Mdes010355-RA	2	Reactome: R-HSA-4755609;Reactome: R-HSA-446199	"Defective DHDDS causes retinitis pigmentosa 59";"Synthesis of Dolichyl-phosphate"
Mdes009752-RA	7	Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-5620922;Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-6798695	"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"BBSome-mediated cargo-targeting to cilium";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Neutrophil degranulation"
Mdes002257-RA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
Mdes008401-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Mdes005617-RC	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Mdes009928-RA	2	KEGG: 00030+2.7.1.15;Reactome: R-HSA-71336	"Pentose phosphate pathway";"Pentose phosphate pathway"
Mdes010535-RA	5	KEGG: 00640+1.2.4.4;KEGG: 00280+1.2.4.4;Reactome: R-HSA-70895;Reactome: R-HSA-389661;MetaCyc: PWY-5046	"Propanoate metabolism";"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism";"Glyoxylate metabolism and glycine degradation";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA"
Mdes002988-RB	9	Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-68962;Reactome: R-HSA-69205;Reactome: R-HSA-68616;Reactome: R-HSA-68867;Reactome: R-HSA-176187	"CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Activation of the pre-replicative complex";"G1/S-Specific Transcription";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress"
Mdes002739-RA	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
Mdes009477-RA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
Mdes006894-RB	2	Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
Mdes014080-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes019769-RA	6	MetaCyc: PWY-2941;MetaCyc: PWY-5097;KEGG: 00261+4.3.3.7;MetaCyc: PWY-8088;KEGG: 00300+4.3.3.7;MetaCyc: PWY-2942	"L-lysine biosynthesis II";"L-lysine biosynthesis VI";"Monobactam biosynthesis";"Dipicolinate biosynthesis";"Lysine biosynthesis";"L-lysine biosynthesis III"
Mdes012638-RA	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
Mdes016118-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes011979-RA	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
Mdes013069-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes003413-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Mdes000638-RB	12	MetaCyc: PWY-6969;KEGG: 00480+1.1.1.42;Reactome: R-HSA-428890;MetaCyc: PWY-7268;MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-7124;KEGG: 00720+1.1.1.42;MetaCyc: PWY-7254;MetaCyc: PWY-6549;MetaCyc: PWY-5913;KEGG: 00020+1.1.1.42	"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Glutathione metabolism";"Role of ABL in ROBO-SLIT signaling";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"Ethylene biosynthesis V (engineered)";"Carbon fixation pathways in prokaryotes";"TCA cycle VII (acetate-producers)";"L-glutamine biosynthesis III";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)"
Mdes004510-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes001541-RB	2	Reactome: R-HSA-196843;Reactome: R-HSA-3214847	"Vitamin B2 (riboflavin) metabolism";"HATs acetylate histones"
Mdes012505-RA	5	MetaCyc: PWY-6987;KEGG: 00785+2.3.1.181;Reactome: R-HSA-389661;MetaCyc: PWY-7382;KEGG: 00785+6.3.1.20	"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism"
Mdes001089-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes018643-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Mdes009987-RA	13	Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes015372-RA	4	Reactome: R-HSA-5625970;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434	"RHO GTPases activate KTN1";"Kinesins";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes018366-RA	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
Mdes012787-RA	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Mdes016677-RA	8	Reactome: R-HSA-3214841;Reactome: R-HSA-212300;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-9609690;Reactome: R-HSA-8943724;Reactome: R-HSA-4551638;Reactome: R-HSA-8953750	"PKMTs methylate histone lysines";"PRC2 methylates histones and DNA";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HCMV Early Events";"Regulation of PTEN gene transcription";"SUMOylation of chromatin organization proteins";"Transcriptional Regulation by E2F6"
Mdes000218-RA	2	KEGG: 00450+2.7.9.3;MetaCyc: PWY-6281	"Selenocompound metabolism";"L-selenocysteine biosynthesis II (archaea and eukaryotes)"
Mdes005142-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Mdes016148-RA	13	MetaCyc: PWY-6545;MetaCyc: PWY-7210;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7184;KEGG: 00480+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-7222;MetaCyc: PWY-7227;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198;MetaCyc: PWY-7220;MetaCyc: PWY-7226;KEGG: 00230+1.17.4.1	"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Interconversion of nucleotide di- and triphosphates";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism"
Mdes012869-RD	5	Reactome: R-HSA-196807;MetaCyc: PWY-7221;Reactome: R-HSA-73621;Reactome: R-HSA-74259;KEGG: 00230+2.7.4.8	"Nicotinate metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine catabolism";"Purine catabolism";"Purine metabolism"
Mdes001324-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes002044-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes008990-RB	17	Reactome: R-HSA-9014325;Reactome: R-HSA-168638;Reactome: R-HSA-937042;Reactome: R-HSA-9645460;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-1169091;Reactome: R-HSA-5357956;Reactome: R-HSA-937072;Reactome: R-HSA-975163;Reactome: R-HSA-4086398;Reactome: R-HSA-5607764;Reactome: R-HSA-450321;Reactome: R-HSA-445989;Reactome: R-HSA-5689880;Reactome: R-HSA-9020702;Reactome: R-HSA-450302	"TICAM1,TRAF6-dependent induction of TAK1 complex";"NOD1/2 Signaling Pathway";"IRAK2 mediated activation of TAK1 complex";"Alpha-protein kinase 1 signaling pathway";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Activation of NF-kappaB in B cells";"TNFR1-induced NFkappaB signaling pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"Ca2+ pathway";"CLEC7A (Dectin-1) signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Ub-specific processing proteases";"Interleukin-1 signaling";"activated TAK1 mediates p38 MAPK activation"
Mdes006308-RA	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
Mdes016503-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes018580-RA	5	MetaCyc: PWY-5747;KEGG: 00640+4.2.1.99;KEGG: 00020+4.2.1.3;KEGG: 00720+4.2.1.3;KEGG: 00630+4.2.1.3	"2-methylcitrate cycle II";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism"
Mdes002764-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes015953-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes011675-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes016926-RA	44	Reactome: R-HSA-6802955;Reactome: R-HSA-5668599;Reactome: R-HSA-170968;Reactome: R-HSA-162658;Reactome: R-HSA-8943724;Reactome: R-HSA-982772;Reactome: R-HSA-9635465;Reactome: R-HSA-9649948;Reactome: R-HSA-6802946;Reactome: R-HSA-444257;Reactome: R-HSA-879415;Reactome: R-HSA-74749;Reactome: R-HSA-5674499;Reactome: R-HSA-6802952;Reactome: R-HSA-2559585;Reactome: R-HSA-456926;Reactome: R-HSA-3371453;Reactome: R-HSA-5674135;Reactome: R-HSA-8940973;Reactome: R-HSA-5663213;Reactome: R-HSA-375165;Reactome: R-HSA-2559580;Reactome: R-HSA-8939211;KEGG: 04150+2.7.11.24;Reactome: R-HSA-202670;Reactome: R-HSA-198753;Reactome: R-HSA-5654727;Reactome: R-HSA-1295596;Reactome: R-HSA-445144;Reactome: R-HSA-5654732;Reactome: R-HSA-112409;Reactome: R-HSA-2029482;Reactome: R-HSA-9634638;Reactome: R-HSA-881907;Reactome: R-HSA-450341;Reactome: R-HSA-6811558;Reactome: R-HSA-2559582;Reactome: R-HSA-5654733;Reactome: R-HSA-2871796;Reactome: R-HSA-6802948;Reactome: R-HSA-5673001;Reactome: R-HSA-5654726;Reactome: R-HSA-9627069;Reactome: R-HSA-5675221	"Paradoxical activation of RAF signaling by kinase inactive BRAF";"RHO GTPases Activate NADPH Oxidases";"Frs2-mediated activation";"Golgi Cisternae Pericentriolar Stack Reorganization";"Regulation of PTEN gene transcription";"Growth hormone receptor signaling";"Suppression of apoptosis";"Signaling downstream of RAS mutants";"Signaling by moderate kinase activity BRAF mutants";"RSK activation";"Advanced glycosylation endproduct receptor signaling";"Signal attenuation";"Negative feedback regulation of MAPK pathway";"Signaling by BRAF and RAF fusions";"Oncogene Induced Senescence";"Thrombin signalling through proteinase activated receptors (PARs)";"Regulation of HSF1-mediated heat shock response";"MAP2K and MAPK activation";"RUNX2 regulates osteoblast differentiation";"RHO GTPases Activate WASPs and WAVEs";"NCAM signaling for neurite out-growth";"Oxidative Stress Induced Senescence";"ESR-mediated signaling";"mTOR signaling pathway";"ERKs are inactivated";"ERK/MAPK targets";"Negative regulation of FGFR2 signaling";"Spry regulation of FGF signaling";"Signal transduction by L1";"Negative regulation of FGFR3 signaling";"RAF-independent MAPK1/3 activation";"Regulation of actin dynamics for phagocytic cup formation";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Gastrin-CREB signalling pathway via PKC and MAPK";"Activation of the AP-1 family of transcription factors";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Senescence-Associated Secretory Phenotype (SASP)";"Negative regulation of FGFR4 signaling";"FCERI mediated MAPK activation";"Signaling by high-kinase activity BRAF mutants";"RAF/MAP kinase cascade";"Negative regulation of FGFR1 signaling";"Regulation of the apoptosome activity";"Negative regulation of MAPK pathway"
Mdes018595-RA	1	KEGG: 00290+4.2.1.33	"Valine, leucine and isoleucine biosynthesis"
Mdes001565-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Mdes016730-RA	14	KEGG: 00630+2.1.2.1;KEGG: 00460+2.1.2.1;MetaCyc: PWY-5497;KEGG: 00670+2.1.2.1;MetaCyc: PWY-3661-1;KEGG: 00260+2.1.2.1;Reactome: R-HSA-196757;MetaCyc: PWY-3841;MetaCyc: PWY-181;KEGG: 00680+2.1.2.1;MetaCyc: PWY-2161;MetaCyc: PWY-1622;MetaCyc: PWY-3661;MetaCyc: PWY-2201	"Glyoxylate and dicarboxylate metabolism";"Cyanoamino acid metabolism";"Purine nucleobases degradation II (anaerobic)";"One carbon pool by folate";"Glycine betaine degradation II (mammalian)";"Glycine, serine and threonine metabolism";"Metabolism of folate and pterines";"Folate transformations II (plants)";"Photorespiration ";"Methane metabolism";"Folate polyglutamylation";"Formaldehyde assimilation I (serine pathway)";"Glycine betaine degradation I";"Folate transformations I"
Mdes006634-RA	7	Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390471;Reactome: R-HSA-5620922;Reactome: R-HSA-6814122;Reactome: R-HSA-6798695;Reactome: R-HSA-390450	"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"BBSome-mediated cargo-targeting to cilium";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Neutrophil degranulation";"Folding of actin by CCT/TriC"
Mdes005695-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Mdes006502-RA	6	MetaCyc: PWY-7286;MetaCyc: PWY-7285;MetaCyc: PWY-6829;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470;Reactome: R-HSA-6787450	"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Methylwyosine biosynthesis";"Trna methylation (yeast)";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion";"tRNA modification in the mitochondrion"
Mdes003069-RA	13	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
Mdes004111-RA	2	Reactome: R-HSA-427413;Reactome: R-HSA-3214847	"NoRC negatively regulates rRNA expression";"HATs acetylate histones"
Mdes007684-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Mdes019384-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes016924-RA	2	Reactome: R-HSA-212676;Reactome: R-HSA-181429	"Dopamine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle"
Mdes010667-RB	5	MetaCyc: PWY-6122;KEGG: 00230+6.3.5.3;MetaCyc: PWY-6121;Reactome: R-HSA-73817;MetaCyc: PWY-6277	"5-aminoimidazole ribonucleotide biosynthesis II";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis"
Mdes016910-RA	2	Reactome: R-HSA-6785470;Reactome: R-HSA-6784531	"tRNA processing in the mitochondrion";"tRNA processing in the nucleus"
Mdes008921-RA	1	Reactome: R-HSA-901032	"ER Quality Control Compartment (ERQC)"
Mdes009617-RB	6	MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-7656	"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
Mdes003993-RB	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes009197-RA	2	Reactome: R-HSA-3214815;Reactome: R-HSA-427413	"HDACs deacetylate histones";"NoRC negatively regulates rRNA expression"
Mdes005432-RB	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Mdes001714-RA	6	KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7039	"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule"
Mdes006807-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes011795-RA	2	Reactome: R-HSA-72706;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition"
Mdes006374-RA	5	Reactome: R-HSA-6782135;Reactome: R-HSA-72163;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823	"Dual incision in TC-NER";"mRNA Splicing - Major Pathway";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex"
Mdes008256-RA	1	KEGG: 00531+3.2.1.35	"Glycosaminoglycan degradation"
Mdes004683-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-194840	"RAB GEFs exchange GTP for GDP on RABs";"Rho GTPase cycle"
Mdes016657-RA	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
Mdes015176-RA	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
Mdes005218-RA	8	KEGG: 05165+2.7.11.1;Reactome: R-HSA-975957;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"Human papillomavirus infection";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
Mdes001675-RB	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
Mdes005175-RB	3	Reactome: R-HSA-202427;Reactome: R-HSA-6807004;Reactome: R-HSA-6798695	"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity";"Neutrophil degranulation"
Mdes006535-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes018844-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Mdes016845-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes011173-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
Mdes001198-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes003029-RB	4	KEGG: 00983+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48;Reactome: R-HSA-73614	"Drug metabolism - other enzymes";"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism";"Pyrimidine salvage"
Mdes014399-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes014624-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes000919-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
Mdes008719-RA	5	KEGG: 00052+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00561+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22	"Galactose metabolism";"Stachyose degradation";"Glycerolipid metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series"
Mdes007126-RA	4	KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;Reactome: R-HSA-499943	"Thiamine metabolism";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates"
Mdes015266-RA	1	Reactome: R-HSA-525793	"Myogenesis"
Mdes001288-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes001103-RA	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
Mdes004993-RA	3	KEGG: 00230+3.6.1.17;Reactome: R-HSA-3299685;KEGG: 00240+3.6.1.17	"Purine metabolism";"Detoxification of Reactive Oxygen Species";"Pyrimidine metabolism"
Mdes011793-RA	1	Reactome: R-HSA-71288	"Creatine metabolism"
Mdes005639-RA	11	Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-3371497;Reactome: R-HSA-2565942	"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Regulation of PLK1 Activity at G2/M Transition"
Mdes004254-RA	7	MetaCyc: PWY-7214;MetaCyc: PWY-7445;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-6824;MetaCyc: PWY-5469;MetaCyc: PWY-5466	"Baicalein degradation (hydrogen peroxide detoxification)";"Luteolin triglucuronide degradation";"Betanidin degradation";"Phenylpropanoid biosynthesis";"Justicidin B biosynthesis";"Sesamin biosynthesis";"Matairesinol biosynthesis"
Mdes005284-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Mdes000807-RA	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
Mdes017190-RA	10	MetaCyc: PWY-6554;MetaCyc: PWY-4661;Reactome: R-HSA-1855191;MetaCyc: PWY-6369;MetaCyc: PWY-6372;Reactome: R-HSA-1855167;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6362;MetaCyc: PWY-6361;KEGG: 04070+2.7.1.158	"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Synthesis of IPs in the nucleus";"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Synthesis of pyrophosphates in the cytosol";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Phosphatidylinositol signaling system"
Mdes007987-RA	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
Mdes014314-RA	1	KEGG: 00970+6.1.1.5	"Aminoacyl-tRNA biosynthesis"
Mdes006399-RB	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes000466-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes017975-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Mdes010237-RC	13	Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764	"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination"
Mdes002217-RA	5	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1"
Mdes004159-RA	5	KEGG: 00020+1.2.4.2;KEGG: 00380+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661	"Citrate cycle (TCA cycle)";"Tryptophan metabolism";"2-oxoglutarate decarboxylation to succinyl-CoA";"Lysine degradation";"Glyoxylate metabolism and glycine degradation"
Mdes005643-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes005432-RD	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Mdes010431-RA	3	KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348	"Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition"
Mdes009142-RB	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes020023-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1362409	"Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis"
Mdes009906-RA	9	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201;Reactome: R-HSA-400253;Reactome: R-HSA-2426168;Reactome: R-HSA-1368108;Reactome: R-HSA-381340;Reactome: R-HSA-400206;Reactome: R-HSA-1368082;Reactome: R-HSA-191859	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"Circadian Clock";"Activation of gene expression by SREBF (SREBP)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional regulation of white adipocyte differentiation";"Regulation of lipid metabolism by PPARalpha";"RORA activates gene expression";"snRNP Assembly"
Mdes004869-RD	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Mdes017768-RA	4	KEGG: 00030+2.7.1.12;MetaCyc: PWY-6163;KEGG: 00400+2.7.1.71;MetaCyc: PWY-5530	"Pentose phosphate pathway";"Chorismate biosynthesis from 3-dehydroquinate";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Sorbitol biosynthesis II"
Mdes010357-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes000353-RA	13	MetaCyc: PWY-2161;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-6613;MetaCyc: PWY-7909;MetaCyc: PWY-1722;MetaCyc: PWY-2201;MetaCyc: PWY-5497;MetaCyc: PWY-5030;KEGG: 00670+6.3.4.3;Reactome: R-HSA-196757;KEGG: 00720+6.3.4.3;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841	"Folate polyglutamylation";"One carbon pool by folate";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate transformations I";"Purine nucleobases degradation II (anaerobic)";"L-histidine degradation III";"One carbon pool by folate";"Metabolism of folate and pterines";"Carbon fixation pathways in prokaryotes";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)"
Mdes002552-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Mdes013323-RA	17	Reactome: R-HSA-74217;MetaCyc: PWY-6611;Reactome: R-HSA-6798695;MetaCyc: PWY-6609;KEGG: 00230+2.4.2.1;MetaCyc: PWY-5695;MetaCyc: PWY-7179;Reactome: R-HSA-74259;MetaCyc: PWY-6608;MetaCyc: PWY-6644;KEGG: 00240+2.4.2.1;MetaCyc: PWY-6620;MetaCyc: PWY-5532;MetaCyc: PWY-7179-1;MetaCyc: PWY-4202;MetaCyc: PWY-6627;KEGG: 00760+2.4.2.1	"Purine salvage";"Adenine and adenosine salvage V";"Neutrophil degranulation";"Adenine and adenosine salvage III";"Purine metabolism";"Inosine 5'-phosphate degradation";"Purine deoxyribonucleosides degradation I";"Purine catabolism";"Guanosine nucleotides degradation III";"Fluoroacetate and fluorothreonine biosynthesis";"Pyrimidine metabolism";"Guanine and guanosine salvage";"Nucleoside and nucleotide degradation (archaea)";"Purine deoxyribonucleosides degradation II";"Arsenate detoxification I (mammalian)";"Salinosporamide A biosynthesis";"Nicotinate and nicotinamide metabolism"
Mdes019232-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes015551-RA	3	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901;Reactome: R-HSA-8951664	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol";"Neddylation"
Mdes006163-RD	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes015907-RA	4	Reactome: R-HSA-382556;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346;Reactome: R-HSA-5678895	"ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis";"Defective CFTR causes cystic fibrosis"
Mdes006778-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes005883-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes003650-RA	3	MetaCyc: PWY-5067;KEGG: 00500+2.4.1.11;Reactome: R-HSA-3322077	"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Glycogen synthesis"
Mdes000312-RF	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
Mdes019845-RA	11	Reactome: R-HSA-8964539;MetaCyc: PWY-6963;Reactome: R-HSA-210455;MetaCyc: PWY-6964;KEGG: 00630+6.3.1.2;MetaCyc: PWY-5675;KEGG: 00250+6.3.1.2;KEGG: 00220+6.3.1.2;MetaCyc: PWY-381;MetaCyc: PWY-6549;KEGG: 00910+6.3.1.2	"Glutamate and glutamine metabolism";"Ammonia assimilation cycle I";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Ammonia assimilation cycle II";"Glyoxylate and dicarboxylate metabolism";"Nitrate reduction V (assimilatory)";"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis";"Nitrate reduction II (assimilatory)";"L-glutamine biosynthesis III";"Nitrogen metabolism"
Mdes016324-RA	15	MetaCyc: PWY-6886;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6901;MetaCyc: PWY-6142;MetaCyc: PWY-2221;MetaCyc: PWY-7383;MetaCyc: PWY-7218;MetaCyc: PWY-5723;MetaCyc: PWY-7003;KEGG: 00230+2.7.1.40;MetaCyc: PWY-5484;MetaCyc: PWY-1042;KEGG: 00010+2.7.1.40;MetaCyc: PWY-8004;Reactome: R-HSA-70171	"1-butanol autotrophic biosynthesis (engineered)";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Rubisco shunt";"Glycerol degradation to butanol";"Purine metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway I";"Glycolysis"
Mdes012007-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes017378-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes005955-RA	1	Reactome: R-HSA-9018519	"Estrogen-dependent gene expression"
Mdes015858-RA	7	Reactome: R-HSA-5617472;Reactome: R-HSA-9609690;Reactome: R-HSA-8943724;Reactome: R-HSA-3214841;Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-8953750	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HCMV Early Events";"Regulation of PTEN gene transcription";"PKMTs methylate histone lysines";"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Transcriptional Regulation by E2F6"
Mdes001771-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes004599-RA	2	KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7	"Aminobenzoate degradation";"Pyruvate metabolism"
Mdes009270-RA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
Mdes000520-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes004682-RA	3	Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-5696400	"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Dual Incision in GG-NER"
Mdes014760-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes007428-RD	3	Reactome: R-HSA-6785470;Reactome: R-HSA-8868766;Reactome: R-HSA-6784531	"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA processing in the nucleus"
Mdes008143-RA	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
Mdes010556-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes002341-RA	7	MetaCyc: PWY-6906;Reactome: R-HSA-71336;KEGG: 00030+3.1.1.31;MetaCyc: PWY-8004;MetaCyc: PWY-5514;MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6	"Chitin derivatives degradation";"Pentose phosphate pathway";"Pentose phosphate pathway";"Entner-Doudoroff pathway I";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism"
Mdes005615-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Mdes003427-RB	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Mdes007396-RA	30	Reactome: R-HSA-195253;Reactome: R-HSA-2122947;Reactome: R-HSA-69231;Reactome: R-HSA-68949;Reactome: R-HSA-5610785;Reactome: R-HSA-2894862;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1170546;Reactome: R-HSA-2644607;Reactome: R-HSA-187577;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-983168;Reactome: R-HSA-400253;Reactome: R-HSA-202424;Reactome: R-HSA-2871837;Reactome: R-HSA-5607764;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5610780;Reactome: R-HSA-2644606;Reactome: R-HSA-174113;Reactome: R-HSA-5607761;Reactome: R-HSA-9020702;Reactome: R-HSA-5684264;Reactome: R-HSA-2565942;Reactome: R-HSA-8939902;Reactome: R-HSA-917937;Reactome: R-HSA-180534	"Degradation of beta-catenin by the destruction complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Cyclin D associated events in G1";"Orc1 removal from chromatin";"GLI3 is processed to GLI3R by the proteasome";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Prolactin receptor signaling";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Neddylation";"Activation of NF-kappaB in B cells";"Antigen processing: Ubiquitination & Proteasome degradation";"Circadian Clock";"Downstream TCR signaling";"FCERI mediated NF-kB activation";"CLEC7A (Dectin-1) signaling";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Degradation of GLI1 by the proteasome";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"SCF-beta-TrCP mediated degradation of Emi1";"Dectin-1 mediated noncanonical NF-kB signaling";"Interleukin-1 signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Regulation of PLK1 Activity at G2/M Transition";"Regulation of RUNX2 expression and activity";"Iron uptake and transport";"Vpu mediated degradation of CD4"
Mdes005041-RA	17	Reactome: R-HSA-5358565;Reactome: R-HSA-5358606;Reactome: R-HSA-5651801;Reactome: R-HSA-5685942;Reactome: R-HSA-69183;Reactome: R-HSA-5696400;Reactome: R-HSA-69166;Reactome: R-HSA-5656169;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-174437;Reactome: R-HSA-5696397;Reactome: R-HSA-174417;Reactome: R-HSA-174414;Reactome: R-HSA-69091;Reactome: R-HSA-6782210;Reactome: R-HSA-174411	"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Homologous Recombination (HRR)";"Processive synthesis on the lagging strand";"Dual Incision in GG-NER";"Removal of the Flap Intermediate";"Termination of translesion DNA synthesis";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate from the C-strand";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Processive synthesis on the C-strand of the telomere";"Polymerase switching";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching on the C-strand of the telomere"
Mdes002986-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes006920-RA	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
Mdes014127-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes000107-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Mdes010629-RA	1	KEGG: 00970+6.1.1.21	"Aminoacyl-tRNA biosynthesis"
Mdes004918-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes012394-RA	5	Reactome: R-HSA-9033500;KEGG: 00565+2.5.1.26;MetaCyc: PWY-7782;Reactome: R-HSA-9033241;Reactome: R-HSA-75896	"TYSND1 cleaves peroxisomal proteins";"Ether lipid metabolism";"Plasmalogen biosynthesis";"Peroxisomal protein import";"Plasmalogen biosynthesis"
Mdes003608-RA	5	Reactome: R-HSA-6811434;Reactome: R-HSA-5620924;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-1445148	"COPI-dependent Golgi-to-ER retrograde traffic";"Intraflagellar transport";"Kinesins";"MHC class II antigen presentation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes003993-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes018901-RA	7	KEGG: 00670+2.1.2.2;KEGG: 00670+2.1.2.9;MetaCyc: PWY-6613;MetaCyc: PWY-6121;KEGG: 00970+2.1.2.9;Reactome: R-HSA-73817;KEGG: 00230+2.1.2.2	"One carbon pool by folate";"One carbon pool by folate";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"5-aminoimidazole ribonucleotide biosynthesis I";"Aminoacyl-tRNA biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism"
Mdes007935-RA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
Mdes012271-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes002278-RA	2	KEGG: 00510+2.4.1.142;KEGG: 00513+2.4.1.142	"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis"
Mdes009211-RB	3	Reactome: R-HSA-8868766;Reactome: R-HSA-6785470;Reactome: R-HSA-6784531	"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion";"tRNA processing in the nucleus"
Mdes001168-RB	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes019748-RA	12	KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7417;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;MetaCyc: PWY-6803	"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Ether lipid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing"
Mdes000167-RC	14	Reactome: R-HSA-2132295;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-3371497;Reactome: R-HSA-5620924;Reactome: R-HSA-141444;Reactome: R-HSA-1632852;Reactome: R-HSA-5663220	"MHC class II antigen presentation";"Separation of Sister Chromatids";"Aggrephagy";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Intraflagellar transport";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Macroautophagy";"RHO GTPases Activate Formins"
Mdes005849-RA	30	Reactome: R-HSA-917937;Reactome: R-HSA-8939902;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-2565942;Reactome: R-HSA-5684264;Reactome: R-HSA-9020702;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-2644606;Reactome: R-HSA-5607764;Reactome: R-HSA-983168;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-400253;Reactome: R-HSA-187577;Reactome: R-HSA-2644607;Reactome: R-HSA-1170546;Reactome: R-HSA-5610783;Reactome: R-HSA-2894862;Reactome: R-HSA-5610785;Reactome: R-HSA-8854050;Reactome: R-HSA-2122947;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-69231	"Iron uptake and transport";"Regulation of RUNX2 expression and activity";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of PLK1 Activity at G2/M Transition";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Interleukin-1 signaling";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"CLEC7A (Dectin-1) signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Activation of NF-kappaB in B cells";"Neddylation";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Circadian Clock";"SCF(Skp2)-mediated degradation of p27/p21";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Prolactin receptor signaling";"Degradation of GLI2 by the proteasome";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"GLI3 is processed to GLI3R by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"NOTCH1 Intracellular Domain Regulates Transcription";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Cyclin D associated events in G1"
Mdes004109-RD	3	Reactome: R-HSA-2022928;KEGG: 00534+5.1.3.17;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Heparan sulfate biosynthesis (late stages)"
Mdes015962-RA	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
Mdes001831-RA	57	Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-450408;Reactome: R-HSA-6798695;Reactome: R-HSA-5687128;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-5668541;Reactome: R-HSA-349425;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768	"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Neutrophil degranulation";"MAPK6/MAPK4 signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Ub-specific processing proteases";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"TNFR2 non-canonical NF-kB pathway";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Neddylation";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD"
Mdes007625-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes002962-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Mdes006799-RB	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes008166-RA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
Mdes000268-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes014693-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
Mdes006118-RD	3	Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369	"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis"
Mdes000846-RA	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
Mdes018754-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes014052-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes019230-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes008636-RB	2	Reactome: R-HSA-8873719;Reactome: R-HSA-8876198	"RAB geranylgeranylation";"RAB GEFs exchange GTP for GDP on RABs"
Mdes000819-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes004654-RB	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
Mdes002687-RB	3	KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1;Reactome: R-HSA-73843	"Purine metabolism";"Pentose phosphate pathway";"5-Phosphoribose 1-diphosphate biosynthesis"
Mdes017177-RA	56	Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-5362768;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-5668541;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-187577;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-5610783;Reactome: R-HSA-69481	"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"TNFR2 non-canonical NF-kB pathway";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"SCF(Skp2)-mediated degradation of p27/p21";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints"
Mdes013170-RA	33	Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-73772;Reactome: R-HSA-69231;Reactome: R-HSA-69656;Reactome: R-HSA-6782210;Reactome: R-HSA-6796648;Reactome: R-HSA-76042;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-8939236;Reactome: R-HSA-73779;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-5696395;Reactome: R-HSA-69273;Reactome: R-HSA-113418;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-6781827;Reactome: R-HSA-69202;Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167246;Reactome: R-HSA-427413	"Dual incision in TC-NER";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Promoter Escape";"Cyclin D associated events in G1";"Cyclin A:Cdk2-associated events at S phase entry";"Gap-filling DNA repair synthesis and ligation in TC-NER";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"Formation of Incision Complex in GG-NER";"Cyclin A/B1/B2 associated events during G2/M transition";"Formation of the Early Elongation Complex";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Cyclin E associated events during G1/S transition";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Tat-mediated elongation of the HIV-1 transcript";"NoRC negatively regulates rRNA expression"
Mdes006527-RA	3	Reactome: R-HSA-2995383;Reactome: R-HSA-2980766;Reactome: R-HSA-4419969	"Initiation of Nuclear Envelope Reformation";"Nuclear Envelope Breakdown";"Depolymerisation of the Nuclear Lamina"
Mdes000450-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes012868-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Mdes012557-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Mdes006921-RA	6	MetaCyc: PWY-6834;KEGG: 00270+4.1.1.50;KEGG: 00970+6.3.5.7;KEGG: 00330+4.1.1.50;Reactome: R-HSA-2142753;Reactome: R-HSA-351202	"Spermidine biosynthesis III";"Cysteine and methionine metabolism";"Aminoacyl-tRNA biosynthesis";"Arginine and proline metabolism";"Arachidonic acid metabolism";"Metabolism of polyamines"
Mdes000808-RA	3	Reactome: R-HSA-727802;Reactome: R-HSA-5619078;Reactome: R-HSA-6787639	"Transport of nucleotide sugars";"Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)";"GDP-fucose biosynthesis"
Mdes015499-RA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
Mdes000474-RA	5	Reactome: R-HSA-418594;Reactome: R-HSA-375276;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"G alpha (i) signalling events";"Peptide ligand-binding receptors";"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes002584-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes011121-RD	3	Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-114608	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Platelet degranulation"
Mdes017927-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes005696-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes010347-RA	2	Reactome: R-HSA-6804758;Reactome: R-HSA-3214847	"Regulation of TP53 Activity through Acetylation";"HATs acetylate histones"
Mdes000243-RC	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1482798	"Mitochondrial protein import";"Acyl chain remodeling of CL"
Mdes007982-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes019134-RA	16	MetaCyc: PWY-7400;MetaCyc: PWY-6559;MetaCyc: PWY-5154;KEGG: 00300+1.2.1.11;KEGG: 00220+1.2.1.38;MetaCyc: PWY-7153;KEGG: 00261+1.2.1.11;MetaCyc: PWY-5097;MetaCyc: PWY-8088;MetaCyc: PWY-6562;MetaCyc: PWY-6160;MetaCyc: PWY-2941;KEGG: 00270+1.2.1.11;MetaCyc: PWY-2942;MetaCyc: PWY-7977;KEGG: 00260+1.2.1.11	"L-arginine biosynthesis IV (archaebacteria)";"Spermidine biosynthesis II";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Lysine biosynthesis";"Arginine biosynthesis";"Grixazone biosynthesis";"Monobactam biosynthesis";"L-lysine biosynthesis VI";"Dipicolinate biosynthesis";"Norspermidine biosynthesis";"3-dehydroquinate biosynthesis II (archaea)";"L-lysine biosynthesis II";"Cysteine and methionine metabolism";"L-lysine biosynthesis III";"L-methionine biosynthesis IV (archaea)";"Glycine, serine and threonine metabolism"
Mdes011126-RC	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
Mdes012556-RA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
Mdes018426-RA	4	KEGG: 00230+6.3.5.2;Reactome: R-HSA-73817;MetaCyc: PWY-7221;KEGG: 00983+6.3.5.2	"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes"
Mdes003974-RA	4	MetaCyc: PWY-6855;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822	"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)"
Mdes011865-RA	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
Mdes014349-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes006139-RB	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Mdes002189-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes017796-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Mdes010958-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes009133-RA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
Mdes003170-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Mdes018040-RA	7	Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390471;Reactome: R-HSA-5620922;Reactome: R-HSA-6814122;Reactome: R-HSA-6798695;Reactome: R-HSA-390450	"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"BBSome-mediated cargo-targeting to cilium";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Neutrophil degranulation";"Folding of actin by CCT/TriC"
Mdes008179-RA	16	Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition"
Mdes002949-RA	1	Reactome: R-HSA-350562	"Regulation of ornithine decarboxylase (ODC)"
Mdes002492-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes003684-RA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
Mdes009316-RA	12	Reactome: R-HSA-2122947;Reactome: R-HSA-73762;Reactome: R-HSA-2894862;Reactome: R-HSA-9013508;Reactome: R-HSA-210744;Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-5250924;Reactome: R-HSA-3214847;Reactome: R-HSA-1912408;Reactome: R-HSA-350054;Reactome: R-HSA-9013695	"NOTCH1 Intracellular Domain Regulates Transcription";"RNA Polymerase I Transcription Initiation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"B-WICH complex positively regulates rRNA expression";"HATs acetylate histones";"Pre-NOTCH Transcription and Translation";"Notch-HLH transcription pathway";"NOTCH4 Intracellular Domain Regulates Transcription"
Mdes000403-RA	14	MetaCyc: PWY-5080;MetaCyc: PWY-8041;Reactome: R-HSA-75876;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7725;MetaCyc: PWY-6598;MetaCyc: PWY-7724;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199	"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation"
Mdes000481-RA	1	Reactome: R-HSA-5689603	"UCH proteinases"
Mdes005702-RA	57	Reactome: R-HSA-5668541;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-5687128;Reactome: R-HSA-6798695;Reactome: R-HSA-450408	"TNFR2 non-canonical NF-kB pathway";"Neddylation";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Ub-specific processing proteases";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"MAPK6/MAPK4 signaling";"Neutrophil degranulation";"AUF1 (hnRNP D0) binds and destabilizes mRNA"
Mdes016511-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Mdes011524-RA	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
Mdes002066-RA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
Mdes006344-RB	56	Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-5668541;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-187577	"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"TNFR2 non-canonical NF-kB pathway";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"SCF(Skp2)-mediated degradation of p27/p21"
Mdes004387-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes009881-RA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Mdes002510-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes000764-RA	3	KEGG: 00520+1.1.1.271;Reactome: R-HSA-6787639;KEGG: 00051+1.1.1.271	"Amino sugar and nucleotide sugar metabolism";"GDP-fucose biosynthesis";"Fructose and mannose metabolism"
Mdes001601-RA	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
Mdes004807-RA	5	KEGG: 00760+2.7.7.18;MetaCyc: PWY-7761;Reactome: R-HSA-196807;MetaCyc: PWY-5381;MetaCyc: PWY-5653	"Nicotinate and nicotinamide metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde"
Mdes002322-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes006319-RA	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
Mdes014278-RB	5	Reactome: R-HSA-204005;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-983170;Reactome: R-HSA-2132295	"COPII-mediated vesicle transport";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"MHC class II antigen presentation"
Mdes006026-RB	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
Mdes007709-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Mdes018051-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes010041-RB	7	MetaCyc: PWY-4702;KEGG: 00562+3.1.3.25;MetaCyc: PWY-6363;MetaCyc: PWY-2301;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25;KEGG: 00521+3.1.3.25	"Phytate degradation I";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Myo-inositol biosynthesis";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Streptomycin biosynthesis"
Mdes005785-RA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-1442490;Reactome: R-HSA-2132295;Reactome: R-HSA-2022090;Reactome: R-HSA-1679131	"Neutrophil degranulation";"Collagen degradation";"MHC class II antigen presentation";"Assembly of collagen fibrils and other multimeric structures";"Trafficking and processing of endosomal TLR"
Mdes014029-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes005977-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Mdes007868-RA	2	KEGG: 00052+3.2.1.26;KEGG: 00500+3.2.1.26	"Galactose metabolism";"Starch and sucrose metabolism"
Mdes005170-RA	13	MetaCyc: PWY-7226;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-7222;MetaCyc: PWY-7227;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198;MetaCyc: PWY-7184;KEGG: 00480+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-7210;KEGG: 00983+1.17.4.1;MetaCyc: PWY-6545	"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis III"
Mdes001945-RA	13	Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764	"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination"
Mdes018992-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes004396-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes004218-RA	7	Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-6784531;Reactome: R-HSA-168333;Reactome: R-HSA-1655829;Reactome: R-HSA-203927;Reactome: R-HSA-165054	"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"tRNA processing in the nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"MicroRNA (miRNA) biogenesis";"Rev-mediated nuclear export of HIV RNA"
Mdes007928-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Mdes002037-RB	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
Mdes008791-RA	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
Mdes005412-RA	6	Reactome: R-HSA-6782135;MetaCyc: PWY-7511;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"Protein ubiquitination";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Mdes014334-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes000911-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis"
Mdes016426-RA	13	Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902	"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation"
Mdes010720-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Mdes002808-RA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
Mdes007542-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Mdes000344-RA	6	KEGG: 00562+3.1.3.64+3.1.3.95;KEGG: 04070+3.1.3.64+3.1.3.95;MetaCyc: PWY-6368;MetaCyc: PWY-6367;Reactome: R-HSA-1660499;MetaCyc: PWY-6580	"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"D-myo-inositol-5-phosphate metabolism";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol biosynthesis I (bacteria)"
Mdes011158-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes018458-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes008326-RA	1	Reactome: R-HSA-200425	"Carnitine metabolism"
Mdes019182-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes005447-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes014517-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Mdes004428-RA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
Mdes018491-RA	4	KEGG: 00230+6.3.5.2;Reactome: R-HSA-73817;KEGG: 00983+6.3.5.2;MetaCyc: PWY-7221	"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Drug metabolism - other enzymes";"Guanosine ribonucleotides de novo biosynthesis"
Mdes002939-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Mdes005333-RA	4	Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823	"Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex"
Mdes016025-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes002183-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes018301-RA	4	Reactome: R-HSA-8963889;Reactome: R-HSA-381033;Reactome: R-HSA-8874211;Reactome: R-HSA-1655829	"Assembly of active LPL and LIPC lipase complexes";"ATF6 (ATF6-alpha) activates chaperones";"CREB3 factors activate genes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
Mdes019158-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes007704-RB	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Mdes015846-RA	43	Reactome: R-HSA-5467348;Reactome: R-HSA-380270;Reactome: R-HSA-5673000;Reactome: R-HSA-163685;Reactome: R-HSA-389513;Reactome: R-HSA-69273;Reactome: R-HSA-432142;Reactome: R-HSA-6804757;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-141444;Reactome: R-HSA-69231;Reactome: R-HSA-9634600;Reactome: R-HSA-5339716;Reactome: R-HSA-195253;Reactome: R-HSA-2467813;Reactome: R-HSA-163767;Reactome: R-HSA-975957;Reactome: R-HSA-180024;Reactome: R-HSA-5358751;Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5675221;Reactome: R-HSA-5358749;Reactome: R-HSA-5663220;Reactome: R-HSA-4641262;Reactome: R-HSA-6811558;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-2995383;Reactome: R-HSA-5358747;Reactome: R-HSA-8854518;Reactome: R-HSA-113501;Reactome: R-HSA-2465910;Reactome: R-HSA-1295596;Reactome: R-HSA-198753;Reactome: R-HSA-202670;Reactome: R-HSA-5358752;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-2500257;Reactome: R-HSA-5467340	"Truncations of AMER1 destabilize the destruction complex";"Recruitment of mitotic centrosome proteins and complexes";"RAF activation";"Integration of energy metabolism";"CTLA4 inhibitory signaling";"Cyclin A/B1/B2 associated events during G2/M transition";"Platelet sensitization by LDL";"Regulation of TP53 Degradation";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Cyclin D associated events in G1";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Misspliced GSK3beta mutants stabilize beta-catenin";"Degradation of beta-catenin by the destruction complex";"Separation of Sister Chromatids";"PP2A-mediated dephosphorylation of key metabolic factors";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"DARPP-32 events";"S45 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"Negative regulation of MAPK pathway";"S37 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Initiation of Nuclear Envelope Reformation";"S33 mutants of beta-catenin aren't phosphorylated";"AURKA Activation by TPX2";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"MASTL Facilitates Mitotic Progression";"Spry regulation of FGF signaling";"ERK/MAPK targets";"ERKs are inactivated";"T41 mutants of beta-catenin aren't phosphorylated";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"AXIN missense mutants destabilize the destruction complex"
Mdes004576-RB	5	Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"ROS and RNS production in phagocytes";"Ion channel transport";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Amino acids regulate mTORC1"
Mdes014134-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Mdes009343-RA	2	Reactome: R-HSA-4086398;Reactome: R-HSA-418457	"Ca2+ pathway";"cGMP effects"
Mdes005713-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes019304-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes000980-RA	1	KEGG: 04150+2.7.11.24	"mTOR signaling pathway"
Mdes012317-RA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.21	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes012840-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes004576-RA	5	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1"
Mdes003711-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes000802-RB	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Mdes017231-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes013382-RA	4	Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606	"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
Mdes006795-RA	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
Mdes012345-RA	12	KEGG: 00010+4.1.2.13;MetaCyc: PWY-1042;MetaCyc: PWY-5484;MetaCyc: PWY-7385;KEGG: 00710+4.1.2.13;KEGG: 00051+4.1.2.13;Reactome: R-HSA-70171;MetaCyc: PWY-6142;KEGG: 00680+4.1.2.13;KEGG: 00030+4.1.2.13;MetaCyc: PWY-1861;Reactome: R-HSA-70263	"Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Glycolysis II (from fructose 6-phosphate)";"1,3-propanediol biosynthesis (engineered)";"Carbon fixation in photosynthetic organisms";"Fructose and mannose metabolism";"Glycolysis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Methane metabolism";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Gluconeogenesis"
Mdes012290-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes017901-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes014319-RB	3	KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2	"Thiamine metabolism";"Phosphate acquisition";"Riboflavin metabolism"
Mdes008666-RA	19	MetaCyc: PWY-7858;MetaCyc: PWY-7606;MetaCyc: PWY-7854;MetaCyc: PWY-7288;MetaCyc: PWY-6837;KEGG: 00640+1.3.3.6;MetaCyc: PWY-6920;MetaCyc: PWY-7007;MetaCyc: PWY-7574;MetaCyc: PWY-7338;MetaCyc: PWY-7726;KEGG: 00071+1.3.3.6;MetaCyc: PWY-5136;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-7340;MetaCyc: PWY-7291;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7337	"(5Z)-dodecenoate biosynthesis II";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Propanoate metabolism";"6-gingerol analog biosynthesis (engineered)";"Methyl ketone biosynthesis (engineered)";"Propanoyl-coa degradation II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"beta-Alanine metabolism";"10-cis-heptadecenoyl-CoA degradation (yeast)"
Mdes011525-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes014618-RA	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
Mdes012267-RA	1	Reactome: R-HSA-532668	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
Mdes019874-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes010857-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes010618-RA	5	Reactome: R-HSA-73856;Reactome: R-HSA-5357956;Reactome: R-HSA-5357905;Reactome: R-HSA-77588;Reactome: R-HSA-159230	"RNA Polymerase II Transcription Termination";"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"Transport of the SLBP Dependant Mature mRNA"
Mdes008350-RB	3	Reactome: R-HSA-416482;Reactome: R-HSA-193648;Reactome: R-HSA-194840	"G alpha (12/13) signalling events";"NRAGE signals death through JNK";"Rho GTPase cycle"
Mdes000605-RA	11	Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-68962;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-5651801;Reactome: R-HSA-68952;Reactome: R-HSA-6782210;Reactome: R-HSA-5696400;Reactome: R-HSA-174430	"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Activation of the pre-replicative complex";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"PCNA-Dependent Long Patch Base Excision Repair";"DNA replication initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual Incision in GG-NER";"Telomere C-strand synthesis initiation"
Mdes012210-RA	16	MetaCyc: PWY-2221;MetaCyc: PWY-6142;MetaCyc: PWY-6901;MetaCyc: PWY-1622;MetaCyc: PWY-6886;MetaCyc: PWY-5723;MetaCyc: PWY-7218;Reactome: R-HSA-70263;MetaCyc: PWY-7124;KEGG: 00680+4.2.1.11;MetaCyc: PWY-8004;KEGG: 00010+4.2.1.11;MetaCyc: PWY-7003;MetaCyc: PWY-1042;MetaCyc: PWY-5484;Reactome: R-HSA-70171	"Entner-Doudoroff pathway III (semi-phosphorylative)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Superpathway of glucose and xylose degradation";"Formaldehyde assimilation I (serine pathway)";"1-butanol autotrophic biosynthesis (engineered)";"Rubisco shunt";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Gluconeogenesis";"Ethylene biosynthesis V (engineered)";"Methane metabolism";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Glycerol degradation to butanol";"Glycolysis IV (plant cytosol)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis"
Mdes007714-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Mdes007886-RA	30	Reactome: R-HSA-5607764;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-2644606;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-5607761;Reactome: R-HSA-2565942;Reactome: R-HSA-5684264;Reactome: R-HSA-9020702;Reactome: R-HSA-917937;Reactome: R-HSA-8939902;Reactome: R-HSA-180534;Reactome: R-HSA-195253;Reactome: R-HSA-2122947;Reactome: R-HSA-69231;Reactome: R-HSA-68949;Reactome: R-HSA-5610783;Reactome: R-HSA-5610785;Reactome: R-HSA-2894862;Reactome: R-HSA-8854050;Reactome: R-HSA-187577;Reactome: R-HSA-1170546;Reactome: R-HSA-2644607;Reactome: R-HSA-983168;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-400253	"CLEC7A (Dectin-1) signaling";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of PLK1 Activity at G2/M Transition";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Interleukin-1 signaling";"Iron uptake and transport";"Regulation of RUNX2 expression and activity";"Vpu mediated degradation of CD4";"Degradation of beta-catenin by the destruction complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Cyclin D associated events in G1";"Orc1 removal from chromatin";"Degradation of GLI2 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21";"Prolactin receptor signaling";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Activation of NF-kappaB in B cells";"Neddylation";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Circadian Clock"
Mdes007280-RA	56	Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5668541;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-187577;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-5607764;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-180534	"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"TNFR2 non-canonical NF-kB pathway";"Neddylation";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF(Skp2)-mediated degradation of p27/p21";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"CLEC7A (Dectin-1) signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4"
Mdes006097-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Mdes003162-RA	17	KEGG: 00720+6.4.1.2;Reactome: R-HSA-163765;MetaCyc: PWY-5966-1;KEGG: 00640+6.4.1.2;KEGG: 00254+6.4.1.2;Reactome: R-HSA-2426168;MetaCyc: PWY-6679;MetaCyc: PWY-4381;MetaCyc: PWY-6722;Reactome: R-HSA-200425;KEGG: 00061+6.4.1.2;MetaCyc: PWY-5743;MetaCyc: PWY-5744;Reactome: R-HSA-196780;KEGG: 00620+6.4.1.2;Reactome: R-HSA-3371599;MetaCyc: PWY-5789	"Carbon fixation pathways in prokaryotes";"ChREBP activates metabolic gene expression";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Propanoate metabolism";"Aflatoxin biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Candicidin biosynthesis";"Carnitine metabolism";"Fatty acid biosynthesis";"3-hydroxypropanoate cycle";"Glyoxylate assimilation";"Biotin transport and metabolism";"Pyruvate metabolism";"Defective HLCS causes multiple carboxylase deficiency";"3-hydroxypropanoate/4-hydroxybutanate cycle"
Mdes019636-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes009573-RA	5	Reactome: R-HSA-389661;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2	"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Citrate cycle (TCA cycle)"
Mdes006926-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Mdes002621-RD	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes011430-RC	8	MetaCyc: PWY-7980;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;KEGG: 00190+7.1.2.2;Reactome: R-HSA-983712;Reactome: R-HSA-77387;KEGG: 00195+7.1.2.2	"ATP biosynthesis";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Oxidative phosphorylation";"Ion channel transport";"Insulin receptor recycling";"Photosynthesis"
Mdes018119-RA	3	KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9;Reactome: R-HSA-5368286	"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"Mitochondrial translation initiation"
Mdes014041-RA	3	MetaCyc: PWY-5669;KEGG: 00564+4.1.1.65;Reactome: R-HSA-1483213	"Phosphatidylserine and phosphatidylethanolamine biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PE"
Mdes008415-RA	2	Reactome: R-HSA-5619039;Reactome: R-HSA-426117	"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)";"Cation-coupled Chloride cotransporters"
Mdes005904-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes001328-RA	4	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-77595	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs"
Mdes000536-RA	17	Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167152;KEGG: 04660+3.1.3.16;Reactome: R-HSA-674695;KEGG: 04658+3.1.3.16;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-167238;KEGG: 05235+3.1.3.16;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-75955	"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"T cell receptor signaling pathway";"RNA Polymerase II Pre-transcription Events";"Th1 and Th2 cell differentiation";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation"
Mdes005657-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes002569-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1799339	"Neutrophil degranulation";"SRP-dependent cotranslational protein targeting to membrane"
Mdes003645-RB	59	Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-187577;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-5368286;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-5419276;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-5668541;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-5362768;Reactome: R-HSA-5389840;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5607761;Reactome: R-HSA-174084	"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"SCF(Skp2)-mediated degradation of p27/p21";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"Mitochondrial translation initiation";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"Mitochondrial translation termination";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"TNFR2 non-canonical NF-kB pathway";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Mitochondrial translation elongation";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C"
Mdes006490-RA	6	Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-380994	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress"
Mdes004713-RA	9	Reactome: R-HSA-400253;Reactome: R-HSA-5617472;Reactome: R-HSA-2426168;Reactome: R-HSA-1368108;Reactome: R-HSA-1989781;Reactome: R-HSA-2151201;Reactome: R-HSA-381340;Reactome: R-HSA-400206;Reactome: R-HSA-1368082	"Circadian Clock";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Activation of gene expression by SREBF (SREBP)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis";"Transcriptional regulation of white adipocyte differentiation";"Regulation of lipid metabolism by PPARalpha";"RORA activates gene expression"
Mdes004786-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes000920-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes007248-RA	10	Reactome: R-HSA-5607764;Reactome: R-HSA-5676590;Reactome: R-HSA-5607761;Reactome: R-HSA-5684264;Reactome: R-HSA-2565942;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-983168;Reactome: R-HSA-2871837;Reactome: R-HSA-202424	"CLEC7A (Dectin-1) signaling";"NIK-->noncanonical NF-kB signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Regulation of PLK1 Activity at G2/M Transition";"Neddylation";"Activation of NF-kappaB in B cells";"Antigen processing: Ubiquitination & Proteasome degradation";"FCERI mediated NF-kB activation";"Downstream TCR signaling"
Mdes002406-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes004069-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes004538-RA	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
Mdes005829-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes001921-RA	5	Reactome: R-HSA-1989781;Reactome: R-HSA-211981;Reactome: R-HSA-8937144;Reactome: R-HSA-211976;Reactome: R-HSA-211945	"PPARA activates gene expression";"Xenobiotics";"Aryl hydrocarbon receptor signalling";"Endogenous sterols";"Phase I - Functionalization of compounds"
Mdes019885-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Mdes004136-RA	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Mdes009309-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-6814122	"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
Mdes006752-RB	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes014946-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes008449-RA	27	Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-3108214;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408	"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism"
Mdes007831-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes009553-RA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
Mdes003477-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes011037-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes020087-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Mdes017150-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes008153-RA	5	Reactome: R-HSA-68949;Reactome: R-HSA-68827;Reactome: R-HSA-68962;Reactome: R-HSA-69205;Reactome: R-HSA-68867	"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex";"Activation of the pre-replicative complex";"G1/S-Specific Transcription";"Assembly of the pre-replicative complex"
Mdes004411-RA	2	Reactome: R-HSA-6796648;Reactome: R-HSA-6783310	"TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway"
Mdes007162-RA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
Mdes012234-RA	16	Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-174184;Reactome: R-HSA-176407;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174048;Reactome: R-HSA-176408;Reactome: R-HSA-174154;Reactome: R-HSA-176412;Reactome: R-HSA-8853884;Reactome: R-HSA-179409;Reactome: R-HSA-2467813;Reactome: R-HSA-983168	"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Securin";"Phosphorylation of the APC/C";"Transcriptional Regulation by VENTX";"APC-Cdc20 mediated degradation of Nek2A";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes005157-RA	6	Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-72689	"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"Formation of a pool of free 40S subunits"
Mdes014856-RA	3	Reactome: R-HSA-5423646;Reactome: R-HSA-5579007;KEGG: 00220+3.5.1.14	"Aflatoxin activation and detoxification";"Defective ACY1 causes encephalopathy";"Arginine biosynthesis"
Mdes007622-RA	6	MetaCyc: PWY-7442;Reactome: R-HSA-74259;MetaCyc: PWY-6608;MetaCyc: PWY-6606;KEGG: 00230+3.5.4.3;MetaCyc: PWY-5497	"Drosopterin and aurodrosopterin biosynthesis";"Purine catabolism";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Purine metabolism";"Purine nucleobases degradation II (anaerobic)"
Mdes007414-RD	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes010558-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes010035-RA	2	Reactome: R-HSA-456926;Reactome: R-HSA-416482	"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (12/13) signalling events"
Mdes008265-RB	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes006799-RC	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes004470-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes004464-RA	4	Reactome: R-HSA-1799339;Reactome: R-HSA-400511;Reactome: R-HSA-422085;Reactome: R-HSA-381771	"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"
Mdes010792-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes004035-RA	5	Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
Mdes001382-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes012002-RB	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes007114-RA	3	Reactome: R-HSA-201681;Reactome: R-HSA-4641257;Reactome: R-HSA-5689880	"TCF dependent signaling in response to WNT";"Degradation of AXIN";"Ub-specific processing proteases"
Mdes001718-RA	58	Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-5362768;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-174178;Reactome: R-HSA-6791226;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-5668541;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-5689880;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-6798695;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-187577;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-69481;Reactome: R-HSA-5610783	"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Major pathway of rRNA processing in the nucleolus and cytosol";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"TNFR2 non-canonical NF-kB pathway";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"Ub-specific processing proteases";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Neutrophil degranulation";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome"
Mdes017123-RA	6	Reactome: R-HSA-3299685;KEGG: 00630+1.11.1.6;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;Reactome: R-HSA-9033241;Reactome: R-HSA-6798695	"Detoxification of Reactive Oxygen Species";"Glyoxylate and dicarboxylate metabolism";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Peroxisomal protein import";"Neutrophil degranulation"
Mdes015678-RA	13	MetaCyc: PWY-7102;MetaCyc: PWY-7659;MetaCyc: PWY-5122;MetaCyc: PWY-7709;MetaCyc: PWY-6383;MetaCyc: PWY-7410;MetaCyc: PWY-7141;MetaCyc: PWY-7736;MetaCyc: PWY-7182;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-5123;MetaCyc: PWY-7721;MetaCyc: PWY-6859	"Bisabolene biosynthesis (engineered)";"Viridicatumtoxin biosynthesis";"Geranyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Ipsdienol biosynthesis";"(3S)-linalool biosynthesis";"Stellatic acid biosynthesis";"Linalool biosynthesis I";"Terpenoid backbone biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Methyl phomopsenoate biosynthesis";"All-trans-farnesol biosynthesis"
Mdes009804-RA	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
Mdes005355-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Mdes005102-RA	13	Reactome: R-HSA-68952;Reactome: R-HSA-174430;Reactome: R-HSA-6782210;Reactome: R-HSA-5696400;Reactome: R-HSA-5685942;Reactome: R-HSA-5651801;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-68962;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"DNA replication initiation";"Telomere C-strand synthesis initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual Incision in GG-NER";"HDR through Homologous Recombination (HRR)";"PCNA-Dependent Long Patch Base Excision Repair";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Activation of the pre-replicative complex";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes000794-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes006119-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes005166-RA	20	MetaCyc: PWY-7338;MetaCyc: PWY-7574;MetaCyc: PWY-7726;KEGG: 00071+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7340;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7291;MetaCyc: PWY-7337;MetaCyc: PWY-7858;MetaCyc: PWY-7606;MetaCyc: PWY-7854;Reactome: R-HSA-9033241;MetaCyc: PWY-7288;MetaCyc: PWY-6920;MetaCyc: PWY-6837;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7007	"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoyl-coa degradation II";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"beta-Alanine metabolism";"Oleate beta-oxidation (isomerase-dependent, yeast)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"(5Z)-dodecenoate biosynthesis II";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Peroxisomal protein import";"Fatty acid beta-oxidation VII (yeast peroxisome)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Propanoate metabolism";"Methyl ketone biosynthesis (engineered)"
Mdes019091-RA	6	MetaCyc: PWY-6606;MetaCyc: PWY-6608;Reactome: R-HSA-74259;MetaCyc: PWY-7442;KEGG: 00230+3.5.4.3;MetaCyc: PWY-5497	"Guanosine nucleotides degradation II";"Guanosine nucleotides degradation III";"Purine catabolism";"Drosopterin and aurodrosopterin biosynthesis";"Purine metabolism";"Purine nucleobases degradation II (anaerobic)"
Mdes006252-RA	4	MetaCyc: PWY-4361;MetaCyc: PWY-7174;Reactome: R-HSA-72731;KEGG: 00270+5.3.1.23	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Recycling of eIF2:GDP";"Cysteine and methionine metabolism"
Mdes002727-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes017934-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Mdes010239-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes012025-RA	5	Reactome: R-HSA-3928665;Reactome: R-HSA-196025;Reactome: R-HSA-8856828;Reactome: R-HSA-190873;Reactome: R-HSA-8856825	"EPH-ephrin mediated repulsion of cells";"Formation of annular gap junctions";"Clathrin-mediated endocytosis";"Gap junction degradation";"Cargo recognition for clathrin-mediated endocytosis"
Mdes001466-RC	5	Reactome: R-HSA-75035;Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-1445148	"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes014787-RA	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
Mdes015091-RA	6	Reactome: R-HSA-6787450;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470;MetaCyc: PWY-7286;MetaCyc: PWY-7285;MetaCyc: PWY-6829	"tRNA modification in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Methylwyosine biosynthesis";"Trna methylation (yeast)"
Mdes015120-RA	5	KEGG: 00500+2.4.1.18;MetaCyc: PWY-7900;Reactome: R-HSA-189085;MetaCyc: PWY-5067;MetaCyc: PWY-622	"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Digestion of dietary carbohydrate";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch biosynthesis"
Mdes002868-RA	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
Mdes019798-RA	1	Reactome: R-HSA-3000171	"Non-integrin membrane-ECM interactions"
Mdes007020-RA	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
Mdes001313-RA	3	Reactome: R-HSA-418359;Reactome: R-HSA-425561;Reactome: R-HSA-5578775	"Reduction of cytosolic Ca++ levels";"Sodium/Calcium exchangers";"Ion homeostasis"
Mdes019105-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes002517-RA	1	Reactome: R-HSA-3214815	"HDACs deacetylate histones"
Mdes000469-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes003034-RA	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes005240-RA	4	Reactome: R-HSA-2408557;MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11;Reactome: R-HSA-379716	"Selenocysteine synthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
Mdes011526-RA	33	Reactome: R-HSA-5663220;Reactome: R-HSA-4551638;Reactome: R-HSA-3108214;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-159231;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-180746;Reactome: R-HSA-4085377;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-2500257;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-3371453;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;Reactome: R-HSA-141444;Reactome: R-HSA-5619107;Reactome: R-HSA-3232142;Reactome: R-HSA-165054;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"SUMOylation of chromatin organization proteins";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"Transport of Mature mRNA Derived from an Intronless Transcript";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"Nuclear import of Rev protein";"SUMOylation of SUMOylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"Resolution of Sister Chromatid Cohesion";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Regulation of HSF1-mediated heat shock response";"snRNP Assembly";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"ISG15 antiviral mechanism";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of ubiquitinylation proteins";"Rev-mediated nuclear export of HIV RNA";"Separation of Sister Chromatids"
Mdes002741-RA	3	Reactome: R-HSA-2024101;Reactome: R-HSA-2024096;Reactome: R-HSA-2206296	"CS/DS degradation";"HS-GAG degradation";"MPS II - Hunter syndrome"
Mdes011236-RA	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
Mdes003971-RA	2	Reactome: R-HSA-6802953;Reactome: R-HSA-5658442	"RAS signaling downstream of NF1 loss-of-function variants";"Regulation of RAS by GAPs"
Mdes010243-RB	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Mdes000262-RA	4	Reactome: R-HSA-381771;Reactome: R-HSA-422085;Reactome: R-HSA-400511;Reactome: R-HSA-1799339	"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane"
Mdes010291-RB	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes001742-RC	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
Mdes011747-RA	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
Mdes001606-RA	1	Reactome: R-HSA-204626	"Hypusine synthesis from eIF5A-lysine"
Mdes013665-RA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-9639288	"Neutrophil degranulation";"ROS and RNS production in phagocytes";"Ion channel transport";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Amino acids regulate mTORC1"
Mdes008656-RA	19	MetaCyc: PWY-7606;MetaCyc: PWY-7854;MetaCyc: PWY-7858;MetaCyc: PWY-7007;MetaCyc: PWY-7288;MetaCyc: PWY-6920;MetaCyc: PWY-6837;KEGG: 00640+1.3.3.6;KEGG: 00071+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7338;MetaCyc: PWY-7574;MetaCyc: PWY-7726;MetaCyc: PWY-7337;MetaCyc: PWY-7340;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7291	"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"(5Z)-dodecenoate biosynthesis II";"Methyl ketone biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Propanoate metabolism";"Fatty acid degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Propanoyl-coa degradation II";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"beta-Alanine metabolism";"Oleate beta-oxidation (isomerase-dependent, yeast)"
Mdes014415-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Mdes007588-RA	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
Mdes000414-RA	3	Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events"
Mdes004070-RA	33	Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167246;Reactome: R-HSA-427413;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-6781827;Reactome: R-HSA-69202;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-69273;Reactome: R-HSA-5696395;Reactome: R-HSA-6796648;Reactome: R-HSA-76042;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-8939236;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-73772;Reactome: R-HSA-69231;Reactome: R-HSA-69656;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-674695	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Tat-mediated elongation of the HIV-1 transcript";"NoRC negatively regulates rRNA expression";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Cyclin E associated events during G1/S transition";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"Cyclin A/B1/B2 associated events during G2/M transition";"Formation of Incision Complex in GG-NER";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Promoter Escape";"Cyclin D associated events in G1";"Cyclin A:Cdk2-associated events at S phase entry";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events"
Mdes008747-RA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
Mdes006152-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes008010-RA	8	KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1	"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Major pathway of rRNA processing in the nucleolus and cytosol";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway"
Mdes016633-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Mdes000254-RA	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"Intra-Golgi traffic"
Mdes000312-RG	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Mdes008711-RB	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes007384-RA	6	Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7656	"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis"
Mdes012068-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes000865-RA	56	Reactome: R-HSA-5668541;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-450408;Reactome: R-HSA-5687128	"TNFR2 non-canonical NF-kB pathway";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Hedgehog 'on' state";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling"
Mdes016577-RA	7	Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052;MetaCyc: PWY-7039;MetaCyc: PWY-6367;MetaCyc: PWY-6351	"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol-5-phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis"
Mdes000705-RA	4	Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-68884;Reactome: R-HSA-2132295	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"Mitotic Telophase/Cytokinesis";"MHC class II antigen presentation"
Mdes005182-RA	5	KEGG: 00514+2.4.1.109;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7979;MetaCyc: PWY-7921	"Other types of O-glycan biosynthesis";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation I (yeast)"
Mdes005752-RA	10	Reactome: R-HSA-6804756;Reactome: R-HSA-6814122;Reactome: R-HSA-201688;Reactome: R-HSA-8939243;Reactome: R-HSA-2514853;Reactome: R-HSA-445144;Reactome: R-HSA-8948751;Reactome: R-HSA-6798695;Reactome: R-HSA-1483191;Reactome: R-HSA-8934903	"Regulation of TP53 Activity through Phosphorylation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"WNT mediated activation of DVL";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Condensation of Prometaphase Chromosomes";"Signal transduction by L1";"Regulation of PTEN stability and activity";"Neutrophil degranulation";"Synthesis of PC";"Receptor Mediated Mitophagy"
Mdes007212-RA	4	KEGG: 00970+6.1.1.18;Reactome: R-HSA-379726;Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Mdes013731-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes002974-RA	4	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"DARPP-32 events"
Mdes009654-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes006622-RA	7	Reactome: R-HSA-1632852;Reactome: R-HSA-8943724;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-166208;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897	"Macroautophagy";"Regulation of PTEN gene transcription";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"mTORC1-mediated signalling";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes"
Mdes005214-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Mdes009781-RB	8	Reactome: R-HSA-983712;Reactome: R-HSA-182218;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9636467;Reactome: R-HSA-9639288;Reactome: R-HSA-167590	"Ion channel transport";"Nef Mediated CD8 Down-regulation";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Blockage of phagosome acidification";"Amino acids regulate mTORC1";"Nef Mediated CD4 Down-regulation"
Mdes002221-RA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
Mdes020134-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes003864-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes002631-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes002609-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes001714-RB	6	Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;KEGG: 04070+2.7.1.107	"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system"
Mdes006315-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Mdes016323-RA	6	KEGG: 00562+3.1.3.56;Reactome: R-HSA-1855183;MetaCyc: PWY-6362;MetaCyc: PWY-6363;MetaCyc: PWY-6364;KEGG: 04070+3.1.3.56	"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"D-myo-inositol (1,4,5)-trisphosphate degradation";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system"
Mdes003439-RA	1	Reactome: R-HSA-72731	"Recycling of eIF2:GDP"
Mdes001475-RA	1	Reactome: R-HSA-5689603	"UCH proteinases"
Mdes010243-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Mdes001742-RB	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
Mdes007774-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
Mdes010876-RA	13	Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
Mdes006850-RA	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
Mdes005848-RA	30	Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-5610785;Reactome: R-HSA-2894862;Reactome: R-HSA-69231;Reactome: R-HSA-68949;Reactome: R-HSA-2122947;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-400253;Reactome: R-HSA-983168;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-187577;Reactome: R-HSA-2644607;Reactome: R-HSA-1170546;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-2644606;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-917937;Reactome: R-HSA-8939902;Reactome: R-HSA-2565942;Reactome: R-HSA-9020702;Reactome: R-HSA-5684264;Reactome: R-HSA-5607761	"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Cyclin D associated events in G1";"Orc1 removal from chromatin";"NOTCH1 Intracellular Domain Regulates Transcription";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Circadian Clock";"Antigen processing: Ubiquitination & Proteasome degradation";"Activation of NF-kappaB in B cells";"Neddylation";"SCF(Skp2)-mediated degradation of p27/p21";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Prolactin receptor signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"Iron uptake and transport";"Regulation of RUNX2 expression and activity";"Regulation of PLK1 Activity at G2/M Transition";"Interleukin-1 signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Dectin-1 mediated noncanonical NF-kB signaling"
Mdes000686-RA	2	Reactome: R-HSA-429958;Reactome: R-HSA-390471	"mRNA decay by 3' to 5' exoribonuclease";"Association of TriC/CCT with target proteins during biosynthesis"
Mdes012159-RB	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Mdes003670-RB	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
Mdes009648-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes012345-RB	12	Reactome: R-HSA-70171;KEGG: 00051+4.1.2.13;KEGG: 00710+4.1.2.13;KEGG: 00010+4.1.2.13;MetaCyc: PWY-1042;MetaCyc: PWY-7385;MetaCyc: PWY-5484;Reactome: R-HSA-70263;MetaCyc: PWY-6142;MetaCyc: PWY-1861;KEGG: 00680+4.1.2.13;KEGG: 00030+4.1.2.13	"Glycolysis";"Fructose and mannose metabolism";"Carbon fixation in photosynthetic organisms";"Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Gluconeogenesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Methane metabolism";"Pentose phosphate pathway"
Mdes010079-RA	52	Reactome: R-HSA-6803529;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-73980;Reactome: R-HSA-674695;Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-5578749;Reactome: R-HSA-73762;Reactome: R-HSA-112382;Reactome: R-HSA-113418;Reactome: R-HSA-76066;Reactome: R-HSA-167290;Reactome: R-HSA-6796648;Reactome: R-HSA-73779;Reactome: R-HSA-5601884;Reactome: R-HSA-72165;Reactome: R-HSA-76042;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-72203;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-1834949;Reactome: R-HSA-5617472;Reactome: R-HSA-168325;Reactome: R-HSA-72086;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-203927;Reactome: R-HSA-167238;Reactome: R-HSA-76071;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-427413;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-75955;Reactome: R-HSA-73780;Reactome: R-HSA-167162;Reactome: R-HSA-8851708;Reactome: R-HSA-167287;Reactome: R-HSA-5250924;Reactome: R-HSA-167242;Reactome: R-HSA-77075;Reactome: R-HSA-9018519;Reactome: R-HSA-72163	"FGFR2 alternative splicing";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"RNA Polymerase III Transcription Termination";"RNA Polymerase II Pre-transcription Events";"Dual incision in TC-NER";"HIV Transcription Initiation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Transcriptional regulation by small RNAs";"RNA Polymerase I Transcription Initiation";"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Pausing and recovery of HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"PIWI-interacting RNA (piRNA) biogenesis";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Cytosolic sensors of pathogen-associated DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Viral Messenger RNA Synthesis";"mRNA Capping";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"MicroRNA (miRNA) biogenesis";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Elongation";"RNA Polymerase III Chain Elongation";"RNA Polymerase II HIV Promoter Escape";"Signaling by FGFR2 IIIa TM";"HIV elongation arrest and recovery";"B-WICH complex positively regulates rRNA expression";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"Estrogen-dependent gene expression";"mRNA Splicing - Major Pathway"
Mdes012467-RA	2	Reactome: R-HSA-5689896;Reactome: R-HSA-936440	"Ovarian tumor domain proteases";"Negative regulators of DDX58/IFIH1 signaling"
Mdes007678-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes004595-RC	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Mdes005628-RA	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
Mdes012427-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes006083-RA	56	Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-187577;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5668541;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-9010553;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178	"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Neddylation";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"TNFR2 non-canonical NF-kB pathway";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of expression of SLITs and ROBOs";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
Mdes014459-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes003087-RA	3	Reactome: R-HSA-445989;Reactome: R-HSA-1810476;Reactome: R-HSA-933542	"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"RIP-mediated NFkB activation via ZBP1";"TRAF6 mediated NF-kB activation"
Mdes011175-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes014485-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Mdes018148-RA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.7	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes006643-RA	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
Mdes017386-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes001264-RA	3	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
Mdes004159-RB	5	KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661	"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Lysine degradation";"Glyoxylate metabolism and glycine degradation"
Mdes017924-RA	1	MetaCyc: PWY-7533	"Gliotoxin biosynthesis"
Mdes016424-RA	14	MetaCyc: PWY-6886;MetaCyc: PWY-1622;MetaCyc: PWY-6901;MetaCyc: PWY-6142;MetaCyc: PWY-2221;MetaCyc: PWY-7218;MetaCyc: PWY-7003;MetaCyc: PWY-5723;KEGG: 00680+4.2.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-7124;KEGG: 00010+4.2.1.11;MetaCyc: PWY-8004	"1-butanol autotrophic biosynthesis (engineered)";"Formaldehyde assimilation I (serine pathway)";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycerol degradation to butanol";"Rubisco shunt";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Ethylene biosynthesis V (engineered)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway I"
Mdes006993-RB	15	Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5693565;Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693548;Reactome: R-HSA-5685938;Reactome: R-HSA-2559586;Reactome: R-HSA-5693568;Reactome: R-HSA-5685939	"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Sensing of DNA Double Strand Breaks";"HDR through Single Strand Annealing (SSA)";"DNA Damage/Telomere Stress Induced Senescence";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through MMEJ (alt-NHEJ)"
Mdes017239-RA	16	Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-176409;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-176408;Reactome: R-HSA-174154;Reactome: R-HSA-174048;Reactome: R-HSA-2559582;Reactome: R-HSA-174084;Reactome: R-HSA-141430;Reactome: R-HSA-8853884;Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-179409	"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of mitotic proteins";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdc20 mediated degradation of Cyclin B";"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Transcriptional Regulation by VENTX";"Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"APC-Cdc20 mediated degradation of Nek2A"
Mdes000312-RB	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Mdes000625-RA	4	MetaCyc: PWY-6700;Reactome: R-HSA-6782315;MetaCyc: PWY-8106;Reactome: R-HSA-5689603	"Queuosine biosynthesis I (de novo)";"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis III (queuosine salvage)";"UCH proteinases"
Mdes004863-RA	3	Reactome: R-HSA-191859;Reactome: R-HSA-3214858;Reactome: R-HSA-6804760	"snRNP Assembly";"RMTs methylate histone arginines";"Regulation of TP53 Activity through Methylation"
Mdes001961-RA	7	Reactome: R-HSA-5693607;Reactome: R-HSA-156842;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-69473;Reactome: R-HSA-176187	"Processing of DNA double-strand break ends";"Eukaryotic Translation Elongation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress"
Mdes001681-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes005865-RA	10	MetaCyc: PWY-5497;MetaCyc: PWY-5030;Reactome: R-HSA-196757;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-6613;MetaCyc: PWY-7909;MetaCyc: PWY-1722;MetaCyc: PWY-2201	"Purine nucleobases degradation II (anaerobic)";"L-histidine degradation III";"Metabolism of folate and pterines";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"One carbon pool by folate";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate transformations I"
Mdes005996-RA	14	Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-6811436;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-2565942;Reactome: R-HSA-380259	"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Separation of Sister Chromatids";"Mitotic Prometaphase";"COPI-independent Golgi-to-ER retrograde traffic";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes"
Mdes009440-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes015682-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes008094-RA	3	Reactome: R-HSA-5696395;Reactome: R-HSA-3108214;Reactome: R-HSA-5696394	"Formation of Incision Complex in GG-NER";"SUMOylation of DNA damage response and repair proteins";"DNA Damage Recognition in GG-NER"
Mdes019690-RA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
Mdes001664-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes006974-RA	3	Reactome: R-HSA-1614603;Reactome: R-HSA-1614558;Reactome: R-HSA-2408508	"Cysteine formation from homocysteine";"Degradation of cysteine and homocysteine";"Metabolism of ingested SeMet, Sec, MeSec into H2Se"
Mdes008746-RA	2	Reactome: R-HSA-6804758;Reactome: R-HSA-3214847	"Regulation of TP53 Activity through Acetylation";"HATs acetylate histones"
Mdes007322-RA	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
Mdes001615-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Mdes020072-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes003294-RA	5	Reactome: R-HSA-4341670;Reactome: R-HSA-1660662;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295;Reactome: R-HSA-4085001	"Defective NEU1 causes sialidosis";"Glycosphingolipid metabolism";"Neutrophil degranulation";"MHC class II antigen presentation";"Sialic acid metabolism"
Mdes011957-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes020058-RA	10	Reactome: R-HSA-2142789;MetaCyc: PWY-5891;MetaCyc: PWY-5839;MetaCyc: PWY-5890;MetaCyc: PWY-7996;MetaCyc: PWY-5892;KEGG: 00130+2.1.1.163;MetaCyc: PWY-5895;MetaCyc: PWY-5844;MetaCyc: PWY-5849	"Ubiquinol biosynthesis";"Menaquinol-11 biosynthesis";"Menaquinol-7 biosynthesis";"Menaquinol-10 biosynthesis";"Menaquinol-4 biosynthesis I";"Menaquinol-12 biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Menaquinol-13 biosynthesis";"Menaquinol-9 biosynthesis";"Menaquinol-6 biosynthesis"
Mdes009416-RA	6	Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids"
Mdes018136-RA	5	MetaCyc: PWY-6470;MetaCyc: PWY-6471;KEGG: 00550+2.4.1.129;MetaCyc: PWY-5265;MetaCyc: PWY-6385	"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Peptidoglycan biosynthesis";"Peptidoglycan biosynthesis II (staphylococci)";"Peptidoglycan biosynthesis III (mycobacteria)"
Mdes007618-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Mdes011121-RB	3	Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-114608	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Platelet degranulation"
Mdes008624-RA	3	Reactome: R-HSA-5656169;Reactome: R-HSA-110320;Reactome: R-HSA-5685942	"Termination of translesion DNA synthesis";"Translesion Synthesis by POLH";"HDR through Homologous Recombination (HRR)"
Mdes001582-RA	1	MetaCyc: PWY-7437	"Protein O-[N-acetyl]-glucosylation"
Mdes007500-RA	24	Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-9648025;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-8852276;Reactome: R-HSA-6811434;Reactome: R-HSA-5663220;Reactome: R-HSA-6807878;Reactome: R-HSA-5617833;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-2467813;Reactome: R-HSA-190840;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-5626467;Reactome: R-HSA-9609736;Reactome: R-HSA-437239;Reactome: R-HSA-380320;Reactome: R-HSA-8955332	"Mitotic Prometaphase";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Gap junction assembly";"EML4 and NUDC in mitotic spindle formation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"COPI-mediated anterograde transport";"Cilium Assembly";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Separation of Sister Chromatids";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases activate IQGAPs";"Assembly and cell surface presentation of NMDA receptors";"Recycling pathway of L1";"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin"
Mdes018511-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes003492-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes004653-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Mdes007247-RA	7	KEGG: 00562+2.7.1.67;Reactome: R-HSA-1660514;KEGG: 04070+2.7.1.67;MetaCyc: PWY-6352;Reactome: R-HSA-1660516;MetaCyc: PWY-6351;Reactome: R-HSA-1660499	"Inositol phosphate metabolism";"Synthesis of PIPs at the Golgi membrane";"Phosphatidylinositol signaling system";"3-phosphoinositide biosynthesis";"Synthesis of PIPs at the early endosome membrane";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of PIPs at the plasma membrane"
Mdes018164-RA	4	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.6;Reactome: R-HSA-2408522;Reactome: R-HSA-379726	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation"
Mdes000662-RA	3	Reactome: R-HSA-6787450;Reactome: R-HSA-6785470;Reactome: R-HSA-8868766	"tRNA modification in the mitochondrion";"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion"
Mdes005744-RB	12	MetaCyc: PWY-6842;KEGG: 00980+2.5.1.18;MetaCyc: PWY-7112;KEGG: 00983+2.5.1.18;Reactome: R-HSA-264876;MetaCyc: PWY-7533;Reactome: R-HSA-156590;KEGG: 00480+2.5.1.18;KEGG: 00982+2.5.1.18;Reactome: R-HSA-1445148;MetaCyc: PWY-4061;Reactome: R-HSA-5620916	"Glutathione-mediated detoxification II";"Metabolism of xenobiotics by cytochrome P450";"4-hydroxy-2-nonenal detoxification";"Drug metabolism - other enzymes";"Insulin processing";"Gliotoxin biosynthesis";"Glutathione conjugation";"Glutathione metabolism";"Drug metabolism - cytochrome P450";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Glutathione-mediated detoxification I";"VxPx cargo-targeting to cilium"
Mdes007455-RA	7	KEGG: 00270+6.3.2.2;Reactome: R-HSA-174403;MetaCyc: PWY-6840;KEGG: 00480+6.3.2.2;Reactome: R-HSA-5578999;MetaCyc: PWY-8043;MetaCyc: PWY-7255	"Cysteine and methionine metabolism";"Glutathione synthesis and recycling";"Homoglutathione biosynthesis";"Glutathione metabolism";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Ophthalmate biosynthesis";"Ergothioneine biosynthesis I (bacteria)"
Mdes014952-RA	1	Reactome: R-HSA-416476	"G alpha (q) signalling events"
Mdes011914-RA	8	Reactome: R-HSA-5610787;Reactome: R-HSA-983231;Reactome: R-HSA-180024;Reactome: R-HSA-381676;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-164378;Reactome: R-HSA-442720	"Hedgehog 'off' state";"Factors involved in megakaryocyte development and platelet production";"DARPP-32 events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"PKA activation in glucagon signalling";"CREB1 phosphorylation through the activation of Adenylate Cyclase"
Mdes003690-RE	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
Mdes002963-RA	17	Reactome: R-HSA-176409;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-2559582;Reactome: R-HSA-174154;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-8853884;Reactome: R-HSA-176412;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-179409	"APC/C:Cdc20 mediated degradation of mitotic proteins";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Transcriptional Regulation by VENTX";"Phosphorylation of the APC/C";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"APC-Cdc20 mediated degradation of Nek2A"
Mdes012336-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes003524-RA	4	Reactome: R-HSA-2470946;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052	"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion"
Mdes002895-RA	10	Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-210744;Reactome: R-HSA-9013508;Reactome: R-HSA-2197563;Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-8941856;Reactome: R-HSA-9013695	"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"RUNX3 regulates NOTCH signaling";"NOTCH4 Intracellular Domain Regulates Transcription"
Mdes013044-RA	1	Reactome: R-HSA-525793	"Myogenesis"
Mdes001283-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes013308-RA	16	Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72649	"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation"
Mdes006268-RA	4	Reactome: R-HSA-5676590;Reactome: R-HSA-8951664;Reactome: R-HSA-983168;Reactome: R-HSA-5607761	"NIK-->noncanonical NF-kB signaling";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling"
Mdes009305-RA	3	Reactome: R-HSA-114508;Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13	"Effects of PIP2 hydrolysis";"G alpha (z) signalling events";"Phosphatidylinositol signaling system"
Mdes001617-RA	26	Reactome: R-HSA-3371497;Reactome: R-HSA-5626467;Reactome: R-HSA-5617833;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-983189;Reactome: R-HSA-2467813;Reactome: R-HSA-190840;Reactome: R-HSA-2132295;Reactome: R-HSA-380320;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-437239;Reactome: R-HSA-389960;Reactome: R-HSA-9648025;Reactome: R-HSA-389977;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases activate IQGAPs";"Cilium Assembly";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"Kinesins";"Separation of Sister Chromatids";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"MHC class II antigen presentation";"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"Recycling pathway of L1";"Formation of tubulin folding intermediates by CCT/TriC";"EML4 and NUDC in mitotic spindle formation";"Post-chaperonin tubulin folding pathway";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"Aggrephagy";"Gap junction assembly";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs"
Mdes000035-RB	22	Reactome: R-HSA-68877;Reactome: R-HSA-6811558;Reactome: R-HSA-432142;Reactome: R-HSA-5358747;Reactome: R-HSA-9648025;Reactome: R-HSA-5358751;Reactome: R-HSA-5673000;Reactome: R-HSA-5467337;Reactome: R-HSA-5675221;Reactome: R-HSA-196299;Reactome: R-HSA-5467348;Reactome: R-HSA-389513;Reactome: R-HSA-4641262;Reactome: R-HSA-5358749;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-5467340;Reactome: R-HSA-141444;Reactome: R-HSA-5358752;Reactome: R-HSA-5339716;Reactome: R-HSA-195253	"Mitotic Prometaphase";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Platelet sensitization by LDL";"S33 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"S45 mutants of beta-catenin aren't phosphorylated";"RAF activation";"APC truncation mutants have impaired AXIN binding";"Negative regulation of MAPK pathway";"Beta-catenin phosphorylation cascade";"Truncations of AMER1 destabilize the destruction complex";"CTLA4 inhibitory signaling";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S37 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"AXIN missense mutants destabilize the destruction complex";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"T41 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Degradation of beta-catenin by the destruction complex"
Mdes000418-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes007532-RA	9	Reactome: R-HSA-5693568;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-6804756	"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation"
Mdes001003-RA	4	Reactome: R-HSA-71240;Reactome: R-HSA-210991;Reactome: R-HSA-352230;Reactome: R-HSA-5660862	"Tryptophan catabolism";"Basigin interactions";"Amino acid transport across the plasma membrane";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)"
Mdes008265-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Mdes017523-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes006861-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes018152-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes001202-RA	4	Reactome: R-HSA-8951664;KEGG: 00480+3.4.11.1;MetaCyc: PWY-7511;Reactome: R-HSA-349425	"Neddylation";"Glutathione metabolism";"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1"
Mdes009671-RA	13	Reactome: R-HSA-419037;Reactome: R-HSA-1474244;Reactome: R-HSA-186797;Reactome: R-HSA-2022090;Reactome: R-HSA-3000178;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-2214320;Reactome: R-HSA-1650814;Reactome: R-HSA-3000171;Reactome: R-HSA-2243919;Reactome: R-HSA-216083;Reactome: R-HSA-3000157	"NCAM1 interactions";"Extracellular matrix organization";"Signaling by PDGF";"Assembly of collagen fibrils and other multimeric structures";"ECM proteoglycans";"Collagen chain trimerization";"Collagen degradation";"Anchoring fibril formation";"Collagen biosynthesis and modifying enzymes";"Non-integrin membrane-ECM interactions";"Crosslinking of collagen fibrils";"Integrin cell surface interactions";"Laminin interactions"
Mdes006896-RA	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
Mdes016138-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Mdes011596-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes013311-RA	3	MetaCyc: PWY-6368;MetaCyc: PWY-6367;KEGG: 04070+3.1.3.78	"3-phosphoinositide degradation";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system"
Mdes005703-RA	3	Reactome: R-HSA-383280;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"Nuclear Receptor transcription pathway";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Mdes010162-RA	13	Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes015670-RA	2	KEGG: 00500+3.2.1.26;KEGG: 00052+3.2.1.26	"Starch and sucrose metabolism";"Galactose metabolism"
Mdes000561-RA	15	Reactome: R-HSA-416476;Reactome: R-HSA-1660499;Reactome: R-HSA-1433557;Reactome: R-HSA-912631;Reactome: R-HSA-6811558;Reactome: R-HSA-114604;Reactome: R-HSA-9009391;Reactome: R-HSA-1266695;Reactome: R-HSA-1257604;Reactome: R-HSA-912526;Reactome: R-HSA-388841;Reactome: R-HSA-8853659;Reactome: R-HSA-389357;Reactome: R-HSA-512988;Reactome: R-HSA-2219530	"G alpha (q) signalling events";"Synthesis of PIPs at the plasma membrane";"Signaling by SCF-KIT";"Regulation of signaling by CBL";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"GPVI-mediated activation cascade";"Extra-nuclear estrogen signaling";"Interleukin-7 signaling";"PIP3 activates AKT signaling";"Interleukin receptor SHC signaling";"Costimulation by the CD28 family";"RET signaling";"CD28 dependent PI3K/Akt signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Constitutive Signaling by Aberrant PI3K in Cancer"
Mdes008587-RB	2	Reactome: R-HSA-983231;Reactome: R-HSA-8949215	"Factors involved in megakaryocyte development and platelet production";"Mitochondrial calcium ion transport"
Mdes018159-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes012410-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes009481-RA	56	Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-5362768;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-187577	"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Neddylation";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"SCF(Skp2)-mediated degradation of p27/p21"
Mdes010004-RA	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
Mdes006485-RB	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes015048-RA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
Mdes009211-RA	3	Reactome: R-HSA-6785470;Reactome: R-HSA-8868766;Reactome: R-HSA-6784531	"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA processing in the nucleus"
Mdes003122-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes010589-RA	5	Reactome: R-HSA-1222556;MetaCyc: PWY-4983;Reactome: R-HSA-392154;KEGG: 00330+1.14.13.39;KEGG: 00220+1.14.13.39	"ROS and RNS production in phagocytes";"Nitric oxide biosynthesis II (mammals)";"Nitric oxide stimulates guanylate cyclase";"Arginine and proline metabolism";"Arginine biosynthesis"
Mdes005014-RA	4	Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664	"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation"
Mdes004218-RC	7	Reactome: R-HSA-1655829;Reactome: R-HSA-165054;Reactome: R-HSA-203927;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-6784531	"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Rev-mediated nuclear export of HIV RNA";"MicroRNA (miRNA) biogenesis";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"tRNA processing in the nucleus"
Mdes009252-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
Mdes009201-RB	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes000121-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes005347-RA	10	KEGG: 00531+3.2.1.23;KEGG: 00600+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2160916;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2206292;Reactome: R-HSA-2024096	"Glycosaminoglycan degradation";"Sphingolipid metabolism";"Neutrophil degranulation";"Galactose metabolism";"Other glycan degradation";"Hyaluronan uptake and degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"MPS VII - Sly syndrome";"HS-GAG degradation"
Mdes019751-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Mdes007653-RA	11	Reactome: R-HSA-163359;Reactome: R-HSA-170670;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-170660;Reactome: R-HSA-432040;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-163615;Reactome: R-HSA-164378	"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway";"Hedgehog 'off' state";"G alpha (i) signalling events";"Adenylate cyclase activating pathway";"Vasopressin regulates renal water homeostasis via Aquaporins";"Purine metabolism";"G alpha (s) signalling events";"G alpha (z) signalling events";"PKA activation";"PKA activation in glucagon signalling"
Mdes010243-RC	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Mdes004803-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes012637-RA	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
Mdes000468-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes009940-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes011749-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes003266-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes011122-RB	13	Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes012678-RA	7	Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-1362277;Reactome: R-HSA-69202	"G0 and Early G1";"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition"
Mdes004414-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes001223-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-5689880	"HATs acetylate histones";"Ub-specific processing proteases"
Mdes006763-RA	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
Mdes006993-RA	15	Reactome: R-HSA-5693607;Reactome: R-HSA-5693565;Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-6804756;Reactome: R-HSA-5693571;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-2559586;Reactome: R-HSA-5685939;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693548;Reactome: R-HSA-5685938	"Processing of DNA double-strand break ends";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"Regulation of TP53 Activity through Phosphorylation";"Nonhomologous End-Joining (NHEJ)";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"DNA Damage/Telomere Stress Induced Senescence";"HDR through MMEJ (alt-NHEJ)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Sensing of DNA Double Strand Breaks";"HDR through Single Strand Annealing (SSA)"
Mdes012012-RA	2	KEGG: 00510+3.6.1.43;Reactome: R-HSA-446199	"N-Glycan biosynthesis";"Synthesis of Dolichyl-phosphate"
Mdes006632-RC	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes008514-RA	11	KEGG: 00740+3.6.1.9;MetaCyc: PWY-7187;MetaCyc: PWY-6545;KEGG: 00230+3.6.1.9;KEGG: 00240+3.6.1.9;MetaCyc: PWY-7184;MetaCyc: PWY-7821;KEGG: 00760+3.6.1.9;KEGG: 00770+3.6.1.9;KEGG: 00500+3.6.1.9;MetaCyc: PWY-7206	"Riboflavin metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Tunicamycin biosynthesis";"Nicotinate and nicotinamide metabolism";"Pantothenate and CoA biosynthesis";"Starch and sucrose metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation"
Mdes015830-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes010219-RA	7	Reactome: R-HSA-2173795;Reactome: R-HSA-5696394;Reactome: R-HSA-3108214;Reactome: R-HSA-5696400;Reactome: R-HSA-5685939;Reactome: R-HSA-5696395;Reactome: R-HSA-110362	"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"DNA Damage Recognition in GG-NER";"SUMOylation of DNA damage response and repair proteins";"Dual Incision in GG-NER";"HDR through MMEJ (alt-NHEJ)";"Formation of Incision Complex in GG-NER";"POLB-Dependent Long Patch Base Excision Repair"
Mdes007849-RA	2	Reactome: R-HSA-5218920;Reactome: R-HSA-418990	"VEGFR2 mediated vascular permeability";"Adherens junctions interactions"
Mdes013225-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes014058-RA	1	Reactome: R-HSA-390651	"Dopamine receptors"
Mdes018541-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes004538-RC	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
Mdes010077-RA	6	Reactome: R-HSA-9022692;Reactome: R-HSA-9029569;Reactome: R-HSA-9609690;Reactome: R-HSA-1989781;Reactome: R-HSA-3214815;Reactome: R-HSA-9022537	"Regulation of MECP2 expression and activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"HCMV Early Events";"PPARA activates gene expression";"HDACs deacetylate histones";"Loss of MECP2 binding ability to the NCoR/SMRT complex"
Mdes012502-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes008242-RB	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes008711-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes008594-RE	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes001861-RB	18	KEGG: 00250+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00350+2.6.1.1;MetaCyc: PWY-6638;KEGG: 00950+2.6.1.1;MetaCyc: PWY-5913;KEGG: 00400+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00960+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-7383;MetaCyc: PWY-7117;MetaCyc: PWY-7115;KEGG: 00360+2.6.1.1;KEGG: 00270+2.6.1.1;MetaCyc: PWY-6642;KEGG: 00710+2.6.1.1	"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis";"Tyrosine metabolism";"Sulfolactate degradation III";"Isoquinoline alkaloid biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine and proline metabolism";"Novobiocin biosynthesis";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Coenzyme M biosynthesis II";"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Phenylalanine metabolism";"Cysteine and methionine metabolism";"(R)-cysteate degradation";"Carbon fixation in photosynthetic organisms"
Mdes005959-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes016873-RA	13	MetaCyc: PWY-561;MetaCyc: PWY-8086;KEGG: 00020+4.2.1.2;KEGG: 00720+4.2.1.2;MetaCyc: PWY-5392;MetaCyc: PWY-7384;KEGG: 00620+4.2.1.2;MetaCyc: PWY-6969;MetaCyc: PWY-7254;MetaCyc: PWY-5913;MetaCyc: PWY-5690;Reactome: R-HSA-71403;MetaCyc: PWY-6728	"Superpathway of glyoxylate cycle and fatty acid degradation";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Pyruvate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle VII (acetate-producers)";"Partial TCA cycle (obligate autotrophs)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle"
Mdes001202-RB	4	KEGG: 00480+3.4.11.1;Reactome: R-HSA-8951664;MetaCyc: PWY-7511;Reactome: R-HSA-349425	"Glutathione metabolism";"Neddylation";"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1"
Mdes011101-RA	13	KEGG: 04070+3.1.4.11;Reactome: R-HSA-2871796;Reactome: R-HSA-2424491;MetaCyc: PWY-6367;Reactome: R-HSA-1855204;Reactome: R-HSA-2029485;Reactome: R-HSA-9027277;Reactome: R-HSA-2871809;MetaCyc: PWY-7039;MetaCyc: PWY-8052;MetaCyc: PWY-6351;Reactome: R-HSA-202433;KEGG: 00562+3.1.4.11	"Phosphatidylinositol signaling system";"FCERI mediated MAPK activation";"DAP12 signaling";"D-myo-inositol-5-phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"Role of phospholipids in phagocytosis";"Erythropoietin activates Phospholipase C gamma (PLCG)";"FCERI mediated Ca+2 mobilization";"Phosphatidate metabolism, as a signaling molecule";"2-arachidonoylglycerol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Generation of second messenger molecules";"Inositol phosphate metabolism"
Mdes002823-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Mdes007437-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes006898-RA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
Mdes009326-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes012211-RA	26	Reactome: R-HSA-5617472;Reactome: R-HSA-9617629;Reactome: R-HSA-400253;Reactome: R-HSA-201722;Reactome: R-HSA-5621575;Reactome: R-HSA-1989781;Reactome: R-HSA-3214847;Reactome: R-HSA-2894862;Reactome: R-HSA-210744;Reactome: R-HSA-381340;Reactome: R-HSA-933541;Reactome: R-HSA-2122947;Reactome: R-HSA-3899300;Reactome: R-HSA-1234158;Reactome: R-HSA-3371568;Reactome: R-HSA-9013695;Reactome: R-HSA-8941856;Reactome: R-HSA-1912408;Reactome: R-HSA-3134973;Reactome: R-HSA-9018519;Reactome: R-HSA-9013508;Reactome: R-HSA-1368082;Reactome: R-HSA-8866907;Reactome: R-HSA-2644606;Reactome: R-HSA-918233;Reactome: R-HSA-9614657	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of FOXO transcriptional activity by acetylation";"Circadian Clock";"Formation of the beta-catenin:TCF transactivating complex";"CD209 (DC-SIGN) signaling";"PPARA activates gene expression";"HATs acetylate histones";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Transcriptional regulation of white adipocyte differentiation";"TRAF6 mediated IRF7 activation";"NOTCH1 Intracellular Domain Regulates Transcription";"SUMOylation of transcription cofactors";"Regulation of gene expression by Hypoxia-inducible Factor";"Attenuation phase";"NOTCH4 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Pre-NOTCH Transcription and Translation";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Estrogen-dependent gene expression";"NOTCH3 Intracellular Domain Regulates Transcription";"RORA activates gene expression";"Activation of the TFAP2 (AP-2) family of transcription factors";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"TRAF3-dependent IRF activation pathway";"FOXO-mediated transcription of cell death genes"
Mdes001565-RB	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Mdes011317-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes016953-RA	2	Reactome: R-HSA-71240;KEGG: 00380+1.13.11.11	"Tryptophan catabolism";"Tryptophan metabolism"
Mdes008780-RA	4	MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3	"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Thiamine metabolism"
Mdes000418-RB	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes017453-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes012500-RB	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Mdes002673-RA	7	Reactome: R-HSA-5362798;Reactome: R-HSA-5358346;Reactome: R-HSA-5632684;Reactome: R-HSA-5635838;Reactome: R-HSA-5658034;Reactome: R-HSA-5632681;Reactome: R-HSA-373080	"Release of Hh-Np from the secreting cell";"Hedgehog ligand biogenesis";"Hedgehog 'on' state";"Activation of SMO";"HHAT G278V abrogates palmitoylation of Hh-Np";"Ligand-receptor interactions";"Class B/2 (Secretin family receptors)"
Mdes006504-RA	5	Reactome: R-HSA-2132295;Reactome: R-HSA-204005;Reactome: R-HSA-1655829;Reactome: R-HSA-5694530;Reactome: R-HSA-983170	"MHC class II antigen presentation";"COPII-mediated vesicle transport";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"
Mdes014006-RD	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes004112-RB	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Mdes000270-RA	10	KEGG: 00650+2.6.1.19;Reactome: R-HSA-916853;KEGG: 00410+2.6.1.19;MetaCyc: PWY-6535;MetaCyc: PWY-6536;KEGG: 00250+2.6.1.19;MetaCyc: PWY-5022;MetaCyc: PWY-6537;MetaCyc: PWY-4321;KEGG: 00640+2.6.1.19	"Butanoate metabolism";"Degradation of GABA";"beta-Alanine metabolism";"4-aminobutanoate degradation I";"4-aminobutanoate degradation III";"Alanine, aspartate and glutamate metabolism";"4-aminobutanoate degradation V";"4-aminobutanoate degradation II";"L-glutamate degradation IV";"Propanoate metabolism"
Mdes003218-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes008422-RD	4	Reactome: R-HSA-499943;KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541;MetaCyc: PWY-7221	"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Abacavir metabolism";"Guanosine ribonucleotides de novo biosynthesis"
Mdes001801-RB	3	KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029;MetaCyc: PWY-7221	"Purine metabolism";"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis"
Mdes006581-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes010155-RA	2	KEGG: 00900+2.1.1.100;Reactome: R-HSA-163841	"Terpenoid backbone biosynthesis";"Gamma carboxylation, hypusine formation and arylsulfatase activation"
Mdes017396-RA	7	Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-69205;Reactome: R-HSA-69202;Reactome: R-HSA-1362277;Reactome: R-HSA-1362300;Reactome: R-HSA-156711	"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"G1/S-Specific Transcription";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by DREAM complex";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events"
Mdes009581-RA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
Mdes015004-RA	18	KEGG: 00401+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00400+2.6.1.1;MetaCyc: PWY-5913;KEGG: 00950+2.6.1.1;MetaCyc: PWY-6638;KEGG: 00350+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00250+2.6.1.1;MetaCyc: PWY-6642;KEGG: 00270+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00360+2.6.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-7117;MetaCyc: PWY-7383;MetaCyc: PWY-6643;KEGG: 00960+2.6.1.1	"Novobiocin biosynthesis";"Arginine and proline metabolism";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Isoquinoline alkaloid biosynthesis";"Sulfolactate degradation III";"Tyrosine metabolism";"Arginine biosynthesis";"Alanine, aspartate and glutamate metabolism";"(R)-cysteate degradation";"Cysteine and methionine metabolism";"Carbon fixation in photosynthetic organisms";"Phenylalanine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Coenzyme M biosynthesis II";"Tropane, piperidine and pyridine alkaloid biosynthesis"
Mdes006827-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes008042-RA	13	Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226	"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes004349-RA	6	Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68867	"Switching of origins to a post-replicative state";"Unwinding of DNA";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex"
Mdes008804-RA	8	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Signaling by Hippo";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection"
Mdes016802-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes000905-RB	1	Reactome: R-HSA-74217	"Purine salvage"
Mdes010109-RA	34	Reactome: R-HSA-75955;Reactome: R-HSA-167162;Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-167152;Reactome: R-HSA-6807505;Reactome: R-HSA-72086;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-69202;Reactome: R-HSA-6781827;Reactome: R-HSA-6796648;Reactome: R-HSA-8939236;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-76042;Reactome: R-HSA-73762;Reactome: R-HSA-112382;Reactome: R-HSA-113418;Reactome: R-HSA-5696395;Reactome: R-HSA-69273;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-69656;Reactome: R-HSA-69231;Reactome: R-HSA-73772	"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA polymerase II transcribes snRNA genes";"mRNA Capping";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Cyclin E associated events during G1/S transition";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"TP53 Regulates Transcription of DNA Repair Genes";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Initiation";"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex";"Formation of Incision Complex in GG-NER";"Cyclin A/B1/B2 associated events during G2/M transition";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"Dual incision in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin D associated events in G1";"RNA Polymerase I Promoter Escape"
Mdes013931-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes005836-RA	16	Reactome: R-HSA-2559580;Reactome: R-HSA-8943723;Reactome: R-HSA-8986944;Reactome: R-HSA-8853884;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-426496;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-8936459;Reactome: R-HSA-5628897;Reactome: R-HSA-4086398;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-8948700	"Oxidative Stress Induced Senescence";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by MECP2";"Transcriptional Regulation by VENTX";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Post-transcriptional silencing by small RNAs";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"TP53 Regulates Metabolic Genes";"Ca2+ pathway";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation"
Mdes018093-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes008388-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Mdes012589-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Mdes004426-RA	10	Reactome: R-HSA-73780;KEGG: 00740+3.1.3.2;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-76061;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-76066	"RNA Polymerase III Chain Elongation";"Riboflavin metabolism";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Phosphate acquisition";"Thiamine metabolism";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Mdes018462-RA	4	KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268;MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49	"Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Entner-Doudoroff pathway I";"Pentose phosphate pathway"
Mdes010396-RA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
Mdes010428-RB	4	Reactome: R-HSA-5663213;Reactome: R-HSA-3928662;Reactome: R-HSA-8856828;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation"
Mdes012436-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes019859-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Mdes018332-RA	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
Mdes007482-RA	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)"
Mdes010371-RB	1	Reactome: R-HSA-5676934	"Protein repair"
Mdes006503-RA	10	KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-201722;Reactome: R-HSA-5689880;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3214847	"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis";"Formation of the beta-catenin:TCF transactivating complex";"Ub-specific processing proteases";"Human papillomavirus infection";"mTOR signaling pathway";"HATs acetylate histones"
Mdes006839-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes017298-RA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
Mdes007239-RA	3	Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Mdes010078-RA	52	Reactome: R-HSA-72203;Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-1834949;Reactome: R-HSA-6781827;Reactome: R-HSA-5617472;Reactome: R-HSA-168325;Reactome: R-HSA-6807505;Reactome: R-HSA-203927;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-76071;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-427413;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-73780;Reactome: R-HSA-8851708;Reactome: R-HSA-167162;Reactome: R-HSA-77075;Reactome: R-HSA-5250924;Reactome: R-HSA-167242;Reactome: R-HSA-72163;Reactome: R-HSA-9018519;Reactome: R-HSA-6803529;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-73980;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-73762;Reactome: R-HSA-5578749;Reactome: R-HSA-112382;Reactome: R-HSA-167290;Reactome: R-HSA-76066;Reactome: R-HSA-113418;Reactome: R-HSA-6796648;Reactome: R-HSA-72165;Reactome: R-HSA-73779;Reactome: R-HSA-5601884;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-76042	"Processing of Capped Intron-Containing Pre-mRNA";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"Cytosolic sensors of pathogen-associated DNA";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Viral Messenger RNA Synthesis";"RNA polymerase II transcribes snRNA genes";"MicroRNA (miRNA) biogenesis";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"NoRC negatively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"RNA Polymerase III Chain Elongation";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II HIV Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"B-WICH complex positively regulates rRNA expression";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Major Pathway";"Estrogen-dependent gene expression";"FGFR2 alternative splicing";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"RNA Polymerase III Transcription Termination";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"Dual incision in TC-NER";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase I Transcription Initiation";"Transcriptional regulation by small RNAs";"Formation of RNA Pol II elongation complex";"Pausing and recovery of HIV elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Formation of the Early Elongation Complex";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"PIWI-interacting RNA (piRNA) biogenesis";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Initiation And Promoter Clearance"
Mdes007421-RA	5	Reactome: R-HSA-196108;Reactome: R-HSA-211976;Reactome: R-HSA-2395516;Reactome: R-HSA-5579026;Reactome: R-HSA-1362409	"Pregnenolone biosynthesis";"Endogenous sterols";"Electron transport from NADPH to Ferredoxin";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Mitochondrial iron-sulfur cluster biogenesis"
Mdes012408-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes014931-RA	3	MetaCyc: PWY-7426;Reactome: R-HSA-975574;KEGG: 00510+2.4.1.144	"Complex N-linked glycan biosynthesis (vertebrates)";"Reactions specific to the hybrid N-glycan synthesis pathway";"N-Glycan biosynthesis"
Mdes012236-RA	8	Reactome: R-HSA-8866654;MetaCyc: PWY-7159;MetaCyc: PWY-5531;Reactome: R-HSA-189451;Reactome: R-HSA-9033241;Reactome: R-HSA-9603798;KEGG: 00860+4.1.1.37;MetaCyc: PWY-7766	"E3 ubiquitin ligases ubiquitinate target proteins";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)";"Heme biosynthesis";"Peroxisomal protein import";"Class I peroxisomal membrane protein import";"Porphyrin and chlorophyll metabolism";"Heme b biosynthesis IV (Gram-positive bacteria)"
Mdes011947-RA	2	Reactome: R-HSA-376176;Reactome: R-HSA-202433	"Signaling by ROBO receptors";"Generation of second messenger molecules"
Mdes000338-RA	4	KEGG: 00534+2.4.2.26;Reactome: R-HSA-1971475;KEGG: 00532+2.4.2.26;MetaCyc: PWY-6557	"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"A tetrasaccharide linker sequence is required for GAG synthesis";"Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate";"Glycosaminoglycan-protein linkage region biosynthesis"
Mdes004876-RA	12	Reactome: R-HSA-2691232;Reactome: R-HSA-1442490;Reactome: R-HSA-2660826;Reactome: R-HSA-5362798;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-177929;Reactome: R-HSA-2644606;Reactome: R-HSA-1251985;Reactome: R-HSA-75893;Reactome: R-HSA-982772;Reactome: R-HSA-193692	"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Collagen degradation";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Release of Hh-Np from the secreting cell";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Signaling by EGFR";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Nuclear signaling by ERBB4";"TNF signaling";"Growth hormone receptor signaling";"Regulated proteolysis of p75NTR"
Mdes008523-RB	2	Reactome: R-HSA-913709;Reactome: R-HSA-389977	"O-linked glycosylation of mucins";"Post-chaperonin tubulin folding pathway"
Mdes003344-RA	2	Reactome: R-HSA-181429;Reactome: R-HSA-212676	"Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle"
Mdes008376-RA	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
Mdes017681-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Mdes016044-RA	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.1	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes000397-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes012454-RA	27	Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-168276;Reactome: R-HSA-3108214;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-6784531;Reactome: R-HSA-168325	"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"HCMV Late Events";"ISG15 antiviral mechanism";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis"
Mdes011287-RA	16	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Mdes012159-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Mdes013425-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes018659-RA	4	MetaCyc: PWY-6834;KEGG: 00330+4.1.1.19;MetaCyc: PWY-43;MetaCyc: PWY-40	"Spermidine biosynthesis III";"Arginine and proline metabolism";"Putrescine biosynthesis II";"Putrescine biosynthesis I"
Mdes004287-RA	14	Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-426486;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-8986944;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-203927;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408	"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Small interfering RNA (siRNA) biogenesis";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"Transcriptional Regulation by MECP2";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"MicroRNA (miRNA) biogenesis";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation"
Mdes013591-RC	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Mdes009764-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes007132-RB	5	Reactome: R-HSA-8849471;Reactome: R-HSA-3928662;Reactome: R-HSA-186763;Reactome: R-HSA-5218921;Reactome: R-HSA-5658442	"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases";"EPHB-mediated forward signaling";"Downstream signal transduction";"VEGFR2 mediated cell proliferation";"Regulation of RAS by GAPs"
Mdes011487-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Mdes011412-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes009210-RA	1	Reactome: R-HSA-5689901	"Metalloprotease DUBs"
Mdes000097-RA	4	Reactome: R-HSA-937039;Reactome: R-HSA-975144;Reactome: R-HSA-9020702;MetaCyc: PWY-7511	"IRAK1 recruits IKK complex";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Interleukin-1 signaling";"Protein ubiquitination"
Mdes014386-RA	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
Mdes017944-RA	29	Reactome: R-HSA-68962;Reactome: R-HSA-174437;Reactome: R-HSA-5693616;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-5656169;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-110320;Reactome: R-HSA-110312;Reactome: R-HSA-912446;Reactome: R-HSA-5358606;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-176187;Reactome: R-HSA-6804756;Reactome: R-HSA-5358565;Reactome: R-HSA-5656121;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-3371453;Reactome: R-HSA-5696395;Reactome: R-HSA-69166;Reactome: R-HSA-3108214;Reactome: R-HSA-6783310;Reactome: R-HSA-3371511;Reactome: R-HSA-5651801;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942	"Activation of the pre-replicative complex";"Removal of the Flap Intermediate from the C-strand";"Presynaptic phase of homologous DNA pairing and strand exchange";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Termination of translesion DNA synthesis";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion Synthesis by POLH";"Translesion synthesis by REV1";"Meiotic recombination";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Activation of ATR in response to replication stress";"Regulation of TP53 Activity through Phosphorylation";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion synthesis by POLI";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"Regulation of HSF1-mediated heat shock response";"Formation of Incision Complex in GG-NER";"Removal of the Flap Intermediate";"SUMOylation of DNA damage response and repair proteins";"Fanconi Anemia Pathway";"HSF1 activation";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)"
Mdes001542-RC	9	Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-73776	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape"
Mdes005532-RB	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Mdes006363-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes006774-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes018214-RA	9	KEGG: 00250+6.3.1.2;MetaCyc: PWY-5675;KEGG: 00220+6.3.1.2;MetaCyc: PWY-381;MetaCyc: PWY-6549;KEGG: 00910+6.3.1.2;MetaCyc: PWY-6963;MetaCyc: PWY-6964;KEGG: 00630+6.3.1.2	"Alanine, aspartate and glutamate metabolism";"Nitrate reduction V (assimilatory)";"Arginine biosynthesis";"Nitrate reduction II (assimilatory)";"L-glutamine biosynthesis III";"Nitrogen metabolism";"Ammonia assimilation cycle I";"Ammonia assimilation cycle II";"Glyoxylate and dicarboxylate metabolism"
Mdes008087-RA	20	MetaCyc: PWY-6728;KEGG: 00660+6.2.1.5;KEGG: 00020+6.2.1.5;Reactome: R-HSA-6798695;MetaCyc: PWY-5172;Reactome: R-HSA-163765;MetaCyc: PWY-5913;KEGG: 00720+2.3.3.8;Reactome: R-HSA-71403;KEGG: 00020+2.3.3.8;MetaCyc: PWY-5690;Reactome: R-HSA-75105;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5537;MetaCyc: PWY-6969;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-7384;Reactome: R-HSA-1268020	"Methylaspartate cycle";"C5-Branched dibasic acid metabolism";"Citrate cycle (TCA cycle)";"Neutrophil degranulation";"Acetyl-coa biosynthesis III (from citrate)";"ChREBP activates metabolic gene expression";"Partial TCA cycle (obligate autotrophs)";"Carbon fixation pathways in prokaryotes";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Fatty acyl-CoA biosynthesis";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"Pyruvate fermentation to acetate V";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Mitochondrial protein import"
Mdes010291-RC	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes013055-RA	19	Reactome: R-HSA-877300;Reactome: R-HSA-5673000;Reactome: R-HSA-9022692;Reactome: R-HSA-5673001;Reactome: R-HSA-9617324;Reactome: R-HSA-6802952;Reactome: R-HSA-399719;Reactome: R-HSA-111932;Reactome: R-HSA-6802946;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-9649948;Reactome: R-HSA-5576892;Reactome: R-HSA-438066;Reactome: R-HSA-9620244;Reactome: R-HSA-936837;Reactome: R-HSA-6802955;Reactome: R-HSA-3371571;Reactome: R-HSA-442982	"Interferon gamma signaling";"RAF activation";"Regulation of MECP2 expression and activity";"RAF/MAP kinase cascade";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Signaling by BRAF and RAF fusions";"Trafficking of AMPA receptors";"CaMK IV-mediated phosphorylation of CREB";"Signaling by moderate kinase activity BRAF mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Signaling downstream of RAS mutants";"Phase 0 - rapid depolarisation";"Unblocking of NMDA receptors, glutamate binding and activation";"Long-term potentiation";"Ion transport by P-type ATPases";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor"
Mdes011591-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
Mdes012205-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes011464-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Mdes011631-RA	16	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Mdes005487-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes007274-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes009551-RA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
Mdes000537-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes001939-RB	2	Reactome: R-HSA-2514853;Reactome: R-HSA-2299718	"Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes"
Mdes012406-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes001944-RA	18	Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-166208;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-6790901;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902	"Eukaryotic Translation Termination";"Viral mRNA Translation";"mTORC1-mediated signalling";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"rRNA modification in the nucleus and cytosol";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation"
Mdes018367-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes009969-RB	19	Reactome: R-HSA-3000484;Reactome: R-HSA-381426;Reactome: R-HSA-8964041;Reactome: R-HSA-8866423;Reactome: R-HSA-8963888;Reactome: R-HSA-3000497;Reactome: R-HSA-3000480;Reactome: R-HSA-432142;Reactome: R-HSA-8964026;Reactome: R-HSA-5686938;Reactome: R-HSA-8964038;Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-8964046;Reactome: R-HSA-3000471;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-8957275;Reactome: R-HSA-8963901	"Scavenging by Class F Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"LDL remodeling";"VLDL assembly";"Chylomicron assembly";"Scavenging by Class H Receptors";"Scavenging by Class A Receptors";"Platelet sensitization by LDL";"Chylomicron clearance";"Regulation of TLR by endogenous ligand";"LDL clearance";"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"VLDL clearance";"Scavenging by Class B Receptors";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Post-translational protein phosphorylation";"Chylomicron remodeling"
Mdes005668-RA	14	MetaCyc: PWY-8055;MetaCyc: PWY-5667;MetaCyc: PWY-7589;KEGG: 00561+2.3.1.51;Reactome: R-HSA-1483166;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7587;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-7411;MetaCyc: PWY-7417;MetaCyc: PWY-7782	"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Palmitoleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Synthesis of PA";"Glycerophospholipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Phosphatidate biosynthesis (yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Plasmalogen biosynthesis"
Mdes012482-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes012880-RA	14	MetaCyc: PWY-8041;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-7725;MetaCyc: PWY-6598;MetaCyc: PWY-7724;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199	"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation"
Mdes006591-RA	7	Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912	"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane"
Mdes002884-RA	9	KEGG: 00230+6.3.3.1;MetaCyc: PWY-6277;MetaCyc: PWY-6122;KEGG: 00230+6.3.4.13;Reactome: R-HSA-73817;KEGG: 00670+2.1.2.9;MetaCyc: PWY-6121;KEGG: 00970+2.1.2.9;Reactome: R-HSA-196780	"Purine metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"One carbon pool by folate";"5-aminoimidazole ribonucleotide biosynthesis I";"Aminoacyl-tRNA biosynthesis";"Biotin transport and metabolism"
Mdes003995-RB	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes004804-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Mdes019069-RA	4	MetaCyc: PWY-6416;KEGG: 00400+4.2.1.10;MetaCyc: PWY-6163;MetaCyc: PWY-6707	"Quinate degradation II";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Chorismate biosynthesis from 3-dehydroquinate";"Gallate biosynthesis"
Mdes006689-RB	5	MetaCyc: PWY-5737;KEGG: 00330+1.5.5.2;MetaCyc: PWY-6922;Reactome: R-HSA-432722;Reactome: R-HSA-70688	"(5R)-carbapenem carboxylate biosynthesis";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis";"Golgi Associated Vesicle Biogenesis";"Proline catabolism"
Mdes016020-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes011898-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Mdes008606-RA	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
Mdes006780-RA	6	Reactome: R-HSA-162594;Reactome: R-HSA-5651801;Reactome: R-HSA-110362;Reactome: R-HSA-5685939;Reactome: R-HSA-174437;Reactome: R-HSA-69166	"Early Phase of HIV Life Cycle";"PCNA-Dependent Long Patch Base Excision Repair";"POLB-Dependent Long Patch Base Excision Repair";"HDR through MMEJ (alt-NHEJ)";"Removal of the Flap Intermediate from the C-strand";"Removal of the Flap Intermediate"
Mdes007284-RA	3	Reactome: R-HSA-6787450;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470	"tRNA modification in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion"
Mdes006118-RG	3	MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167	"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol"
Mdes014961-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes004454-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes006086-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes008937-RA	2	Reactome: R-HSA-174403;Reactome: R-HSA-5578998	"Glutathione synthesis and recycling";"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)"
Mdes001213-RA	1	Reactome: R-HSA-2565942	"Regulation of PLK1 Activity at G2/M Transition"
Mdes009287-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Mdes010011-RB	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes003414-RA	2	Reactome: R-HSA-1483166;Reactome: R-HSA-1483148	"Synthesis of PA";"Synthesis of PG"
Mdes004179-RA	16	Reactome: R-HSA-8856825;Reactome: R-HSA-8866427;Reactome: R-HSA-437239;Reactome: R-HSA-8964038;Reactome: R-HSA-5099900;Reactome: R-HSA-167590;Reactome: R-HSA-164939;Reactome: R-HSA-190873;Reactome: R-HSA-2132295;Reactome: R-HSA-8856828;Reactome: R-HSA-416993;Reactome: R-HSA-5140745;Reactome: R-HSA-177504;Reactome: R-HSA-182218;Reactome: R-HSA-196025;Reactome: R-HSA-3928665	"Cargo recognition for clathrin-mediated endocytosis";"VLDLR internalisation and degradation";"Recycling pathway of L1";"LDL clearance";"WNT5A-dependent internalization of FZD4";"Nef Mediated CD4 Down-regulation";"Nef mediated downregulation of CD28 cell surface expression";"Gap junction degradation";"MHC class II antigen presentation";"Clathrin-mediated endocytosis";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Retrograde neurotrophin signalling";"Nef Mediated CD8 Down-regulation";"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells"
Mdes017497-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1660662	"Neutrophil degranulation";"Glycosphingolipid metabolism"
Mdes009622-RB	6	Reactome: R-HSA-3371599;MetaCyc: PWY-6987;Reactome: R-HSA-196780;MetaCyc: PWY-7382;KEGG: 00780+6.3.4.15;KEGG: 00785+2.3.1.181	"Defective HLCS causes multiple carboxylase deficiency";"Lipoate biosynthesis and incorporation III (Bacillus)";"Biotin transport and metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Biotin metabolism";"Lipoic acid metabolism"
Mdes018566-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes014937-RA	14	MetaCyc: PWY-7036;MetaCyc: PWY-7601;MetaCyc: PWY-7619;Reactome: R-HSA-75876;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199	"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation"
Mdes007236-RA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes002850-RA	6	Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-5632684;Reactome: R-HSA-201722;Reactome: R-HSA-8866654;Reactome: R-HSA-112382	"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Hedgehog 'on' state";"Formation of the beta-catenin:TCF transactivating complex";"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of RNA Pol II elongation complex"
Mdes015779-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes011511-RA	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
Mdes012094-RA	2	Reactome: R-HSA-1566948;Reactome: R-HSA-2243919	"Elastic fibre formation";"Crosslinking of collagen fibrils"
Mdes003857-RB	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
Mdes008343-RA	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
Mdes009025-RA	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
Mdes003244-RA	10	MetaCyc: PWY-7559;MetaCyc: PWY-6842;MetaCyc: PWY-4041;MetaCyc: PWY-7112;MetaCyc: PWY-5826;KEGG: 00460+2.3.2.2;KEGG: 00430+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13	"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II";"Gamma-glutamyl cycle";"4-hydroxy-2-nonenal detoxification";"Hypoglycin biosynthesis";"Cyanoamino acid metabolism";"Taurine and hypotaurine metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Glutathione metabolism"
Mdes013898-RA	2	Reactome: R-HSA-8876725;Reactome: R-HSA-611105	"Protein methylation";"Respiratory electron transport"
Mdes003997-RA	15	Reactome: R-HSA-167290;Reactome: R-HSA-167158;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-167200;Reactome: R-HSA-167238;Reactome: R-HSA-167152;Reactome: R-HSA-9603505;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-75955	"Pausing and recovery of HIV elongation";"Formation of the HIV-1 Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"NTRK3 as a dependence receptor";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation"
Mdes018326-RA	14	Reactome: R-HSA-5656169;Reactome: R-HSA-5656121;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-5651801;Reactome: R-HSA-5685942;Reactome: R-HSA-69091;Reactome: R-HSA-110312;Reactome: R-HSA-110320;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-6782210;Reactome: R-HSA-174411	"Termination of translesion DNA synthesis";"Translesion synthesis by POLI";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Homologous Recombination (HRR)";"Polymerase switching";"Translesion synthesis by REV1";"Translesion Synthesis by POLH";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching on the C-strand of the telomere"
Mdes001479-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation"
Mdes011104-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes009924-RB	19	Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-6811440;Reactome: R-HSA-2408557;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-6811438;Reactome: R-HSA-8876198;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957	"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Retrograde transport at the Trans-Golgi-Network";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Intra-Golgi traffic";"RAB GEFs exchange GTP for GDP on RABs";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes004958-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Mdes005790-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes000213-RB	6	Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-176187	"Orc1 removal from chromatin";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress"
Mdes012722-RA	8	Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5693579;Reactome: R-HSA-8953750;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938	"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"Homologous DNA Pairing and Strand Exchange";"Transcriptional Regulation by E2F6";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)"
Mdes000143-RA	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes003376-RA	5	Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-1912399;Reactome: R-HSA-1912420;Reactome: R-HSA-5083630	"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Pre-NOTCH Processing in Golgi";"Defective LFNG causes SCDO3"
Mdes014088-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Mdes012415-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Mdes007430-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689	"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits"
Mdes006796-RA	2	Reactome: R-HSA-164843;Reactome: R-HSA-5693571	"2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)"
Mdes009539-RB	7	Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259	"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes"
Mdes014364-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes008400-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes002245-RA	4	KEGG: 00983+6.3.5.2;Reactome: R-HSA-73817;MetaCyc: PWY-7221;KEGG: 00230+6.3.5.2	"Drug metabolism - other enzymes";"Purine ribonucleoside monophosphate biosynthesis";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
Mdes009924-RA	19	Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-8876198;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-6811438;Reactome: R-HSA-72695;Reactome: R-HSA-6811440;Reactome: R-HSA-2408557;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764	"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"RAB GEFs exchange GTP for GDP on RABs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Intra-Golgi traffic";"Formation of the ternary complex, and subsequently, the 43S complex";"Retrograde transport at the Trans-Golgi-Network";"Selenocysteine synthesis";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination"
Mdes008834-RA	7	Reactome: R-HSA-5626467;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877	"RHO GTPases activate IQGAPs";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase"
Mdes002541-RA	3	Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300	"SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors"
Mdes007664-RA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Mdes015246-RA	3	Reactome: R-HSA-446193;KEGG: 00510+2.4.1.267;Reactome: R-HSA-4724289	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Defective ALG6 causes ALG6-CDG (CDG-1c)"
Mdes003857-RA	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Mdes015675-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes015885-RA	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
Mdes006808-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
Mdes005286-RA	10	Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-3214847;Reactome: R-HSA-73779	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"HATs acetylate histones";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
Mdes014117-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes002756-RA	1	Reactome: R-HSA-198933	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
Mdes017156-RA	1	KEGG: 00970+6.1.1.14	"Aminoacyl-tRNA biosynthesis"
Mdes000213-RA	6	Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68867	"Unwinding of DNA";"Switching of origins to a post-replicative state";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex"
Mdes017300-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes007820-RA	4	KEGG: 00510+3.2.1.114;MetaCyc: PWY-7920;KEGG: 00513+3.2.1.114;MetaCyc: PWY-7426	"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (plants)";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)"
Mdes005747-RA	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
Mdes000898-RA	2	Reactome: R-HSA-8964539;Reactome: R-HSA-2151201	"Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis"
Mdes017410-RA	2	KEGG: 00260+1.4.4.2;Reactome: R-HSA-6783984	"Glycine, serine and threonine metabolism";"Glycine degradation"
Mdes015890-RA	10	KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-4061;MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;KEGG: 00460+2.3.2.2;MetaCyc: PWY-7112;MetaCyc: PWY-5826;MetaCyc: PWY-4041;MetaCyc: PWY-7559;MetaCyc: PWY-6842	"Glutathione metabolism";"Glutathione-mediated detoxification I";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Cyanoamino acid metabolism";"4-hydroxy-2-nonenal detoxification";"Hypoglycin biosynthesis";"Gamma-glutamyl cycle";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II"
Mdes016347-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes012479-RA	7	KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Relaxin signaling pathway"
Mdes008623-RA	56	Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-5668541;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-187577	"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Neddylation";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"TNFR2 non-canonical NF-kB pathway";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Hedgehog 'on' state";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21"
Mdes013641-RA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
Mdes016168-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes004949-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes005586-RA	32	Reactome: R-HSA-167158;Reactome: R-HSA-72203;Reactome: R-HSA-167152;Reactome: R-HSA-6807505;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-167238;Reactome: R-HSA-72163;Reactome: R-HSA-9018519;Reactome: R-HSA-77075;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-167162;Reactome: R-HSA-8851708;Reactome: R-HSA-75955;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6803529;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-72165;Reactome: R-HSA-73779;Reactome: R-HSA-6796648	"Formation of the HIV-1 Early Elongation Complex";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA polymerase II transcribes snRNA genes";"mRNA Capping";"Viral Messenger RNA Synthesis";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Major Pathway";"Estrogen-dependent gene expression";"RNA Pol II CTD phosphorylation and interaction with CE";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"RNA Polymerase II HIV Promoter Escape";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"FGFR2 alternative splicing";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"TP53 Regulates Transcription of DNA Repair Genes"
Mdes000486-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-156842	"Respiratory electron transport";"Eukaryotic Translation Elongation"
Mdes006596-RA	5	MetaCyc: PWY-5083;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;Reactome: R-HSA-196807;MetaCyc: PWY-7269	"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)"
Mdes014671-RA	7	Reactome: R-HSA-2660826;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096	"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
Mdes012992-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes000749-RA	11	Reactome: R-HSA-5628897;Reactome: R-HSA-9627069;Reactome: R-HSA-111463;Reactome: R-HSA-611105;Reactome: R-HSA-1268020;Reactome: R-HSA-3299685;Reactome: R-HSA-111464;Reactome: R-HSA-2151201;Reactome: R-HSA-111457;Reactome: R-HSA-111459;Reactome: R-HSA-111458	"TP53 Regulates Metabolic Genes";"Regulation of the apoptosome activity";"SMAC (DIABLO) binds to IAPs";"Respiratory electron transport";"Mitochondrial protein import";"Detoxification of Reactive Oxygen Species";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Transcriptional activation of mitochondrial biogenesis";"Release of apoptotic factors from the mitochondria";"Activation of caspases through apoptosome-mediated cleavage";"Formation of apoptosome"
Mdes006462-RA	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
Mdes011551-RC	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis"
Mdes000386-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Mdes011373-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes011541-RA	6	KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
Mdes008830-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes018807-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes006280-RA	3	MetaCyc: PWY-8099;KEGG: 00790+4.2.1.96;MetaCyc: PWY-7158	"Tetrahydropteridine recycling";"Folate biosynthesis";"L-phenylalanine degradation V"
Mdes015461-RA	6	Reactome: R-HSA-500753;MetaCyc: PWY-7790;KEGG: 00983+2.4.2.10;KEGG: 00240+2.4.2.10;MetaCyc: PWY-5686;MetaCyc: PWY-7791	"Pyrimidine biosynthesis";"UMP biosynthesis II";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"UMP biosynthesis I";"UMP biosynthesis III"
Mdes012081-RA	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
Mdes016996-RA	6	Reactome: R-HSA-9033241;Reactome: R-HSA-6798695;KEGG: 00630+1.11.1.6;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017	"Peroxisomal protein import";"Neutrophil degranulation";"Glyoxylate and dicarboxylate metabolism";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
Mdes011097-RB	4	Reactome: R-HSA-8949613;Reactome: R-HSA-1268020;Reactome: R-HSA-8950505;Reactome: R-HSA-3371453	"Cristae formation";"Mitochondrial protein import";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Regulation of HSF1-mediated heat shock response"
Mdes004504-RA	2	Reactome: R-HSA-2299718;Reactome: R-HSA-2514853	"Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes"
Mdes014489-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes006856-RA	20	MetaCyc: PWY-5136;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7726;MetaCyc: PWY-7574;MetaCyc: PWY-7338;MetaCyc: PWY-7337;MetaCyc: PWY-7291;KEGG: 00410+1.3.3.6;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7340;MetaCyc: PWY-7854;MetaCyc: PWY-7606;MetaCyc: PWY-7858;MetaCyc: PWY-7007;KEGG: 00640+1.3.3.6;MetaCyc: PWY-6837;MetaCyc: PWY-6920;MetaCyc: PWY-7288;Reactome: R-HSA-9033241	"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid degradation";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Propanoyl-coa degradation II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"beta-Alanine metabolism";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(5Z)-dodecenoate biosynthesis II";"Methyl ketone biosynthesis (engineered)";"Propanoate metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Peroxisomal protein import"
Mdes009880-RA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes013164-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes009927-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes000420-RA	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
Mdes000024-RA	4	MetaCyc: PWY-5188;MetaCyc: PWY-5189;Reactome: R-HSA-189451;KEGG: 00860+2.5.1.61	"Tetrapyrrole biosynthesis I (from glutamate)";"Tetrapyrrole biosynthesis II (from glycine)";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
Mdes017770-RA	1	Reactome: R-HSA-196836	"Vitamin C (ascorbate) metabolism"
Mdes013215-RA	42	KEGG: 00071+4.2.1.17+1.1.1.35;KEGG: 00362+4.2.1.17+1.1.1.35;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-7726;MetaCyc: PWY-7094;MetaCyc: PWY-7778;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;KEGG: 00410+4.2.1.17;MetaCyc: PWY-5789;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00623+1.1.1.35;MetaCyc: PWY-6945;MetaCyc: PWY-6946;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6883;MetaCyc: PWY-5109;MetaCyc: PWY-7401;MetaCyc: PWY-6583;MetaCyc: PWY-6944;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-5138;MetaCyc: PWY-7606;MetaCyc: PWY-7656;MetaCyc: PWY-7779;KEGG: 00640+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-5136;KEGG: 00592+4.2.1.17;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-7216;MetaCyc: PWY-6863;MetaCyc: PWY-7007;KEGG: 00360+4.2.1.17;MetaCyc: PWY-7654;MetaCyc: PWY-5177	"Fatty acid degradation";"Benzoate degradation";"Valine, leucine and isoleucine degradation";"Benzoyl-coa degradation I (aerobic)";"Carbon fixation pathways in prokaryotes";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid salvage";"2-methylpropene degradation";"Tryptophan metabolism";"Aminobenzoate degradation";"beta-Alanine metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Butanoate metabolism";"Toluene degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Limonene and pinene degradation";"Pyruvate fermentation to butanol II (engineered)";"Fermentation to 2-methylbutanoate";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Pyruvate fermentation to butanol I";"Androstenedione degradation";"Caprolactam degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Spodoptera littoralis pheromone biosynthesis";"Methyl tert-butyl ether degradation";"Propanoate metabolism";"Butanoate metabolism";"4-hydroxybenzoate biosynthesis III (plants)";"Lysine degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"alpha-Linolenic acid metabolism";"Fatty acid elongation";"Fatty acid degradation";"Geraniol degradation";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Pyruvate fermentation to hexanol (engineered)";"Methyl ketone biosynthesis (engineered)";"Phenylalanine metabolism";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Glutaryl-coa degradation"
Mdes000071-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes003726-RC	7	Reactome: R-HSA-5663220;Reactome: R-HSA-3299685;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"Detoxification of Reactive Oxygen Species";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids"
Mdes003856-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes008874-RA	4	Reactome: R-HSA-6807505;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"RNA polymerase II transcribes snRNA genes";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes003976-RA	16	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes011540-RA	14	KEGG: 00260+2.1.2.1;MetaCyc: PWY-3661-1;KEGG: 00670+2.1.2.1;KEGG: 00460+2.1.2.1;MetaCyc: PWY-5497;KEGG: 00630+2.1.2.1;KEGG: 00680+2.1.2.1;MetaCyc: PWY-3841;MetaCyc: PWY-181;Reactome: R-HSA-196757;MetaCyc: PWY-3661;MetaCyc: PWY-2161;MetaCyc: PWY-1622;MetaCyc: PWY-2201	"Glycine, serine and threonine metabolism";"Glycine betaine degradation II (mammalian)";"One carbon pool by folate";"Cyanoamino acid metabolism";"Purine nucleobases degradation II (anaerobic)";"Glyoxylate and dicarboxylate metabolism";"Methane metabolism";"Folate transformations II (plants)";"Photorespiration ";"Metabolism of folate and pterines";"Glycine betaine degradation I";"Folate polyglutamylation";"Formaldehyde assimilation I (serine pathway)";"Folate transformations I"
Mdes008546-RA	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
Mdes000519-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes007868-RB	2	KEGG: 00052+3.2.1.26;KEGG: 00500+3.2.1.26	"Galactose metabolism";"Starch and sucrose metabolism"
Mdes010799-RA	7	Reactome: R-HSA-204174;KEGG: 00010+1.2.4.1;Reactome: R-HSA-70268;Reactome: R-HSA-5362517;KEGG: 00620+1.2.4.1;Reactome: R-HSA-389661;KEGG: 00020+1.2.4.1	"Regulation of pyruvate dehydrogenase (PDH) complex";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Signaling by Retinoic Acid";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)"
Mdes008554-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Mdes019835-RA	12	MetaCyc: PWY-5855;Reactome: R-HSA-2142789;KEGG: 00130+1.14.99.60;MetaCyc: PWY-6708;MetaCyc: PWY-5857;MetaCyc: PWY-5870;MetaCyc: PWY-5856;MetaCyc: PWY-5871;MetaCyc: PWY-5873;MetaCyc: PWY-7230;MetaCyc: PWY-7233;MetaCyc: PWY-5872	"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)"
Mdes004412-RA	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
Mdes000039-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes006329-RA	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
Mdes013177-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes007596-RA	3	Reactome: R-HSA-430039;Reactome: R-HSA-450385;Reactome: R-HSA-450513	"mRNA decay by 5' to 3' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
Mdes006378-RA	9	Reactome: R-HSA-2022928;Reactome: R-HSA-3656253;Reactome: R-HSA-2024096;Reactome: R-HSA-3560783;Reactome: R-HSA-975634;Reactome: R-HSA-1971475;Reactome: R-HSA-4420332;Reactome: R-HSA-3560801;Reactome: R-HSA-3656237	"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"HS-GAG degradation";"Defective B4GALT7 causes EDS, progeroid type";"Retinoid metabolism and transport";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective B3GAT3 causes JDSSDHD";"Defective EXT2 causes exostoses 2"
Mdes007434-RB	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Mdes015466-RA	6	MetaCyc: PWY-5686;KEGG: 00240+2.4.2.10;MetaCyc: PWY-7791;KEGG: 00983+2.4.2.10;MetaCyc: PWY-7790;Reactome: R-HSA-500753	"UMP biosynthesis I";"Pyrimidine metabolism";"UMP biosynthesis III";"Drug metabolism - other enzymes";"UMP biosynthesis II";"Pyrimidine biosynthesis"
Mdes018149-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes000127-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes008915-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes007587-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes004213-RA	2	Reactome: R-HSA-5205685;Reactome: R-HSA-1268020	"Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import"
Mdes008337-RA	2	Reactome: R-HSA-8953750;Reactome: R-HSA-8939243	"Transcriptional Regulation by E2F6";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Mdes009208-RB	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
Mdes015855-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes007246-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-171319	"rRNA modification in the nucleus and cytosol";"Telomere Extension By Telomerase"
Mdes000740-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Mdes000905-RC	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
Mdes004574-RB	5	Reactome: R-HSA-8875360;Reactome: R-HSA-8856825;Reactome: R-HSA-182971;Reactome: R-HSA-6807004;Reactome: R-HSA-8856828	"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation";"Negative regulation of MET activity";"Clathrin-mediated endocytosis"
Mdes004506-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes008333-RA	6	MetaCyc: PWY-7286;MetaCyc: PWY-7285;MetaCyc: PWY-6829;Reactome: R-HSA-6785470;Reactome: R-HSA-8868766;Reactome: R-HSA-6787450	"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Methylwyosine biosynthesis";"Trna methylation (yeast)";"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA modification in the mitochondrion"
Mdes017666-RA	6	KEGG: 00230+3.5.4.10+2.1.2.3;MetaCyc: PWY-6124;KEGG: 00670+2.1.2.3;MetaCyc: PWY-6123;MetaCyc: PWY-7234;Reactome: R-HSA-73817	"Purine metabolism";"Inosine-5'-phosphate biosynthesis II";"One carbon pool by folate";"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III";"Purine ribonucleoside monophosphate biosynthesis"
Mdes011263-RB	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes003133-RA	5	Reactome: R-HSA-5674400;Reactome: R-HSA-6804757;Reactome: R-HSA-1257604;Reactome: R-HSA-389357;Reactome: R-HSA-5218920	"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of TP53 Degradation";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling";"VEGFR2 mediated vascular permeability"
Mdes003748-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Mdes004877-RC	2	Reactome: R-HSA-5673001;Reactome: R-HSA-8853659	"RAF/MAP kinase cascade";"RET signaling"
Mdes018769-RA	1	MetaCyc: PWY-7533	"Gliotoxin biosynthesis"
Mdes012755-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes009539-RF	7	Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380270	"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes"
Mdes009123-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes011945-RA	3	MetaCyc: PWY-5129;Reactome: R-HSA-1660661;KEGG: 00600+1.14.19.17	"Sphingolipid biosynthesis (plants)";"Sphingolipid de novo biosynthesis";"Sphingolipid metabolism"
Mdes002882-RE	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes009929-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes009099-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes015673-RA	5	MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00561+3.2.1.22	"Stachyose degradation";"Galactose metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycerolipid metabolism"
Mdes008316-RA	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
Mdes014567-RA	2	KEGG: 00052+3.2.1.26;KEGG: 00500+3.2.1.26	"Galactose metabolism";"Starch and sucrose metabolism"
Mdes016640-RA	3	Reactome: R-HSA-8963684;KEGG: 00643+1.13.11.5;KEGG: 00350+1.13.11.5	"Tyrosine catabolism";"Styrene degradation";"Tyrosine metabolism"
Mdes010261-RA	9	Reactome: R-HSA-6802946;Reactome: R-HSA-6798695;Reactome: R-HSA-6802948;Reactome: R-HSA-9649948;Reactome: R-HSA-5674135;Reactome: R-HSA-114608;Reactome: R-HSA-6802952;Reactome: R-HSA-445355;Reactome: R-HSA-6802955	"Signaling by moderate kinase activity BRAF mutants";"Neutrophil degranulation";"Signaling by high-kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"MAP2K and MAPK activation";"Platelet degranulation";"Signaling by BRAF and RAF fusions";"Smooth Muscle Contraction";"Paradoxical activation of RAF signaling by kinase inactive BRAF"
Mdes008258-RA	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
Mdes001647-RA	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693579	"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange"
Mdes016590-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Intra-Golgi traffic"
Mdes010627-RA	13	KEGG: 00531+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-7883;KEGG: 00513+3.2.1.52;Reactome: R-HSA-1660662;Reactome: R-HSA-2022857;Reactome: R-HSA-2024101;KEGG: 00604+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-6902;KEGG: 00511+3.2.1.52	"Glycosaminoglycan degradation";"Chitin degradation III (Serratia)";"Anhydromuropeptides recycling II";"Various types of N-glycan biosynthesis";"Glycosphingolipid metabolism";"Keratan sulfate degradation";"CS/DS degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Hyaluronan uptake and degradation";"Chitin degradation II (Vibrio)";"Other glycan degradation"
Mdes000519-RD	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes014325-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Mdes008231-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Mdes016595-RB	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Mdes016791-RA	4	MetaCyc: PWY-7204;Reactome: R-HSA-964975;KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282	"Pyridoxal 5'-phosphate salvage II (plants)";"Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis"
Mdes011993-RA	10	KEGG: 00710+5.3.1.1;MetaCyc: PWY-5484;MetaCyc: PWY-1042;KEGG: 00051+5.3.1.1;Reactome: R-HSA-70171;KEGG: 00010+5.3.1.1;MetaCyc: PWY-6142;Reactome: R-HSA-70263;KEGG: 00562+5.3.1.1;MetaCyc: PWY-7003	"Carbon fixation in photosynthetic organisms";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Fructose and mannose metabolism";"Glycolysis";"Glycolysis / Gluconeogenesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Gluconeogenesis";"Inositol phosphate metabolism";"Glycerol degradation to butanol"
Mdes005944-RA	8	Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-6798695;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-8943724	"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Neutrophil degranulation";"Macroautophagy";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Regulation of PTEN gene transcription"
Mdes002561-RA	11	Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700;Reactome: R-HSA-193692;Reactome: R-HSA-9013507;Reactome: R-HSA-9017802;Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Regulated proteolysis of p75NTR";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus"
Mdes019679-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Mdes014263-RA	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
Mdes001374-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes013591-RF	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Mdes001041-RA	6	Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-4411364;Reactome: R-HSA-8951430;Reactome: R-HSA-201722;Reactome: R-HSA-4086398	"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"RUNX3 regulates WNT signaling";"Formation of the beta-catenin:TCF transactivating complex";"Ca2+ pathway"
Mdes017835-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes016489-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes008325-RA	14	Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167158;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167200;Reactome: R-HSA-167243;Reactome: R-HSA-167238	"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation"
Mdes001365-RA	1	Reactome: R-HSA-9617828	"FOXO-mediated transcription of cell cycle genes"
Mdes007337-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
Mdes003966-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes006127-RA	2	Reactome: R-HSA-418594;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
Mdes009476-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression";"PPARA activates gene expression"
Mdes018186-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Mdes017013-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes001995-RA	2	Reactome: R-HSA-6798695;MetaCyc: PWY-7511	"Neutrophil degranulation";"Protein ubiquitination"
Mdes013195-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes007487-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes016109-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Mdes017437-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes010087-RA	2	Reactome: R-HSA-6807505;Reactome: R-HSA-72163	"RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway"
Mdes000539-RB	13	Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression"
Mdes009083-RA	4	Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-3371497	"MHC class II antigen presentation";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Mdes010813-RA	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
Mdes011491-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes011804-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes010603-RA	26	Reactome: R-HSA-5651801;Reactome: R-HSA-5685942;Reactome: R-HSA-69183;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-69166;Reactome: R-HSA-8866654;Reactome: R-HSA-5358565;Reactome: R-HSA-5656121;Reactome: R-HSA-69205;Reactome: R-HSA-4615885;Reactome: R-HSA-5358606;Reactome: R-HSA-174414;Reactome: R-HSA-69091;Reactome: R-HSA-110320;Reactome: R-HSA-110312;Reactome: R-HSA-6782210;Reactome: R-HSA-1362277;Reactome: R-HSA-174411;Reactome: R-HSA-5656169;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-174437;Reactome: R-HSA-5696397;Reactome: R-HSA-174417;Reactome: R-HSA-6804114	"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Homologous Recombination (HRR)";"Processive synthesis on the lagging strand";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"Removal of the Flap Intermediate";"E3 ubiquitin ligases ubiquitinate target proteins";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion synthesis by POLI";"G1/S-Specific Transcription";"SUMOylation of DNA replication proteins";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Processive synthesis on the C-strand of the telomere";"Polymerase switching";"Translesion Synthesis by POLH";"Translesion synthesis by REV1";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription of E2F targets under negative control by DREAM complex";"Polymerase switching on the C-strand of the telomere";"Termination of translesion DNA synthesis";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Removal of the Flap Intermediate from the C-strand";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Telomere C-strand (Lagging Strand) Synthesis";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"
Mdes009882-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes009246-RA	33	MetaCyc: PWY-5076;MetaCyc: PWY-5078;KEGG: 00980+1.1.1.1;MetaCyc: PWY-7013;MetaCyc: PWY-6313;KEGG: 00350+1.1.1.1;MetaCyc: PWY-5082;MetaCyc: PWY-1801;MetaCyc: PWY-7396;KEGG: 00625+1.1.1.1;KEGG: 00626+1.1.1.1;MetaCyc: PWY-6333;MetaCyc: PWY-7798;MetaCyc: PWY-6587;MetaCyc: PWY-6802;KEGG: 00680+1.1.1.284;MetaCyc: PWY-5480;MetaCyc: PWY-5079;KEGG: 00592+1.1.1.1;KEGG: 00260+1.1.1.1;MetaCyc: PWY-7118;MetaCyc: PWY-5751;KEGG: 00010+1.1.1.1;KEGG: 00830+1.1.1.1;KEGG: 00982+1.1.1.1;MetaCyc: PWY-7111;Reactome: R-HSA-71384;MetaCyc: PWY-5057;MetaCyc: PWY-6342;MetaCyc: PWY-5486;MetaCyc: PWY-6871;MetaCyc: PWY-3162;KEGG: 00071+1.1.1.1	"L-leucine degradation III";"L-isoleucine degradation II";"Metabolism of xenobiotics by cytochrome P450";"(S)-propane-1,2-diol degradation";"Serotonin degradation";"Tyrosine metabolism";"L-methionine degradation III";"Formaldehyde oxidation II (glutathione-dependent)";"Butanol and isobutanol biosynthesis (engineered)";"Chloroalkane and chloroalkene degradation";"Naphthalene degradation";"Acetaldehyde biosynthesis I";"Protein S-nitrosylation and denitrosylation";"Pyruvate fermentation to ethanol III";"Salidroside biosynthesis";"Methane metabolism";"Pyruvate fermentation to ethanol I";"L-phenylalanine degradation III";"alpha-Linolenic acid metabolism";"Glycine, serine and threonine metabolism";"Chitin degradation to ethanol";"Phenylethanol biosynthesis";"Glycolysis / Gluconeogenesis";"Retinol metabolism";"Drug metabolism - cytochrome P450";"Pyruvate fermentation to isobutanol (engineered)";"Ethanol oxidation";"L-valine degradation II";"Noradrenaline and adrenaline degradation";"Pyruvate fermentation to ethanol II";"3-methylbutanol biosynthesis (engineered)";"L-tryptophan degradation V (side chain pathway)";"Fatty acid degradation"
Mdes010845-RA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
Mdes019057-RA	30	Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-73772;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-5696400;Reactome: R-HSA-427413;Reactome: R-HSA-5696395;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-2564830;Reactome: R-HSA-73863;Reactome: R-HSA-76042;Reactome: R-HSA-77075;Reactome: R-HSA-73779	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase I Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"HIV Transcription Initiation";"Dual incision in TC-NER";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Dual Incision in GG-NER";"NoRC negatively regulates rRNA expression";"Formation of Incision Complex in GG-NER";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"Cytosolic iron-sulfur cluster assembly";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
Mdes010923-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes004635-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes010348-RB	2	KEGG: 00280+1.3.8.4;Reactome: R-HSA-70895	"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism"
Mdes004924-RA	24	Reactome: R-HSA-380320;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-437239;Reactome: R-HSA-3371497;Reactome: R-HSA-5626467;Reactome: R-HSA-983189;Reactome: R-HSA-5617833;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-190840;Reactome: R-HSA-2467813;Reactome: R-HSA-8852276;Reactome: R-HSA-5663220;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-190861	"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"Recycling pathway of L1";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases activate IQGAPs";"Kinesins";"Cilium Assembly";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Separation of Sister Chromatids";"The role of GTSE1 in G2/M progression after G2 checkpoint";"RHO GTPases Activate Formins";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Aggrephagy";"Gap junction assembly"
Mdes000286-RA	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
Mdes007441-RB	1	Reactome: R-HSA-1483255	"PI Metabolism"
Mdes010877-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes014057-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes007506-RA	3	Reactome: R-HSA-9645722;Reactome: R-HSA-111471;Reactome: R-HSA-140837	"Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function";"Apoptotic factor-mediated response";"Intrinsic Pathway of Fibrin Clot Formation"
Mdes004773-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes007279-RB	7	KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Relaxin signaling pathway"
Mdes002247-RA	17	Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-6799198	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Complex I biogenesis"
Mdes012084-RA	13	KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-5687128;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-416482;Reactome: R-HSA-3928662;KEGG: 05165+2.7.11.1;Reactome: R-HSA-416476;KEGG: 04150+2.7.11.1	"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"NRAGE signals death through JNK";"Rho GTPase cycle";"MAPK6/MAPK4 signaling";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"G alpha (12/13) signalling events";"EPHB-mediated forward signaling";"Human papillomavirus infection";"G alpha (q) signalling events";"mTOR signaling pathway"
Mdes018286-RA	4	Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes009201-RA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes020046-RA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Mdes004429-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340	"PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation"
Mdes001574-RA	18	MetaCyc: PWY-7416;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482839;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-6803;Reactome: R-HSA-1482801;MetaCyc: PWY-7417;Reactome: R-HSA-1482922;MetaCyc: PWY-8053;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482925	"Phospholipid remodeling (phosphatidylcholine, yeast)";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Linoleic acid metabolism";"Arachidonic acid metabolism";"Acyl chain remodelling of PE";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PI";"Anandamide biosynthesis II";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Synthesis of PA";"Glycerophospholipid metabolism";"Acyl chain remodelling of PG"
Mdes006117-RA	8	Reactome: R-HSA-5689880;Reactome: R-HSA-5620912;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Ub-specific processing proteases";"Anchoring of the basal body to the plasma membrane";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Mdes007861-RA	6	MetaCyc: PWY-6124;MetaCyc: PWY-7234;KEGG: 00230+4.1.1.21;MetaCyc: PWY-6123;KEGG: 00230+6.3.2.6;Reactome: R-HSA-73817	"Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis III";"Purine metabolism";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis"
Mdes009947-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes009150-RA	6	Reactome: R-HSA-8936459;Reactome: R-HSA-3769402;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-5617472;Reactome: R-HSA-8951664	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Deactivation of the beta-catenin transactivating complex";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Neddylation"
Mdes007430-RC	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-975957	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes009199-RA	29	Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-73772;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-77075;Reactome: R-HSA-76042;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-73762;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-5696395;Reactome: R-HSA-113418;Reactome: R-HSA-5696400;Reactome: R-HSA-427413;Reactome: R-HSA-73776;Reactome: R-HSA-75953	"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"Dual incision in TC-NER";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Promoter Escape";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase I Transcription Initiation";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of Incision Complex in GG-NER";"Formation of the Early Elongation Complex";"Dual Incision in GG-NER";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation"
Mdes003994-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes008789-RA	3	Reactome: R-HSA-4086398;Reactome: R-HSA-418457;Reactome: R-HSA-392517	"Ca2+ pathway";"cGMP effects";"Rap1 signalling"
Mdes007464-RB	4	Reactome: R-HSA-1632852;Reactome: R-HSA-983168;Reactome: R-HSA-6798695;Reactome: R-HSA-6802952	"Macroautophagy";"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"Signaling by BRAF and RAF fusions"
Mdes005320-RA	13	Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes002575-RA	16	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation"
Mdes000650-RA	3	KEGG: 00600+3.1.4.12;MetaCyc: PWY-7277;Reactome: R-HSA-1660662	"Sphingolipid metabolism";"Sphingolipid biosynthesis (mammals)";"Glycosphingolipid metabolism"
Mdes009227-RA	7	Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066	"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Mdes002935-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-212436;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway";"PPARA activates gene expression"
Mdes004403-RB	4	Reactome: R-HSA-381771;Reactome: R-HSA-422085;Reactome: R-HSA-1799339;Reactome: R-HSA-400511	"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and deacylation of Ghrelin";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"
Mdes005175-RC	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6807004;Reactome: R-HSA-202427	"Neutrophil degranulation";"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains"
Mdes000063-RA	4	MetaCyc: PWY-7383;MetaCyc: PWY-8040;MetaCyc: PWY-8072;KEGG: 00473+5.1.1.1	"Anaerobic energy metabolism (invertebrates, cytosol)";"Ansatrienin biosynthesis";"Alanine racemization";"D-Alanine metabolism"
Mdes006668-RA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
Mdes000915-RA	7	MetaCyc: PWY-5461;MetaCyc: PWY-7445;MetaCyc: PWY-7214;MetaCyc: PWY-5466;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5469;MetaCyc: PWY-6824	"Betanidin degradation";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Matairesinol biosynthesis";"Phenylpropanoid biosynthesis";"Sesamin biosynthesis";"Justicidin B biosynthesis"
Mdes002079-RA	3	KEGG: 00480+1.1.1.44;KEGG: 00030+1.1.1.44;Reactome: R-HSA-71336	"Glutathione metabolism";"Pentose phosphate pathway";"Pentose phosphate pathway"
Mdes007424-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes015342-RA	18	MetaCyc: PWY-7383;MetaCyc: PWY-7117;KEGG: 00960+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00360+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00270+2.6.1.1;MetaCyc: PWY-6642;MetaCyc: PWY-7115;MetaCyc: PWY-6638;KEGG: 00250+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00950+2.6.1.1;MetaCyc: PWY-5913;KEGG: 00400+2.6.1.1;KEGG: 00330+2.6.1.1	"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Coenzyme M biosynthesis II";"Phenylalanine metabolism";"Carbon fixation in photosynthetic organisms";"Cysteine and methionine metabolism";"(R)-cysteate degradation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Sulfolactate degradation III";"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis";"Tyrosine metabolism";"Novobiocin biosynthesis";"Isoquinoline alkaloid biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine and proline metabolism"
Mdes009314-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes004118-RC	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
Mdes016132-RA	56	Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5668541;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-187577	"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Neddylation";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"TNFR2 non-canonical NF-kB pathway";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Ub-specific processing proteases";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"SCF(Skp2)-mediated degradation of p27/p21"
Mdes002632-RA	2	Reactome: R-HSA-5205685;Reactome: R-HSA-1268020	"Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import"
Mdes007256-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes016524-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes006791-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes010358-RA	1	Reactome: R-HSA-379716	"Cytosolic tRNA aminoacylation"
Mdes000189-RA	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
Mdes011156-RA	1	Reactome: R-HSA-3000178	"ECM proteoglycans"
Mdes001401-RA	4	Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712	"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport"
Mdes005760-RA	7	KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
Mdes002166-RA	27	Reactome: R-HSA-72086;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-159236;Reactome: R-HSA-975957;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-73856;Reactome: R-HSA-72203;Reactome: R-HSA-111367;Reactome: R-HSA-6803529;Reactome: R-HSA-72187;Reactome: R-HSA-975956;Reactome: R-HSA-72163;Reactome: R-HSA-9010553;Reactome: R-HSA-167242;Reactome: R-HSA-72165;Reactome: R-HSA-8851708;Reactome: R-HSA-159227;Reactome: R-HSA-77588;Reactome: R-HSA-159230;Reactome: R-HSA-77595;Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-159231;Reactome: R-HSA-191859	"mRNA Capping";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Termination";"Processing of Capped Intron-Containing Pre-mRNA";"SLBP independent Processing of Histone Pre-mRNAs";"FGFR2 alternative splicing";"mRNA 3'-end processing";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"mRNA Splicing - Major Pathway";"Regulation of expression of SLITs and ROBOs";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Minor Pathway";"Signaling by FGFR2 IIIa TM";"Transport of the SLBP independent Mature mRNA";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"Transport of the SLBP Dependant Mature mRNA";"Processing of Intronless Pre-mRNAs";"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Transport of Mature mRNA Derived from an Intronless Transcript";"snRNP Assembly"
Mdes004670-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes018537-RA	17	Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-6790901;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Mdes007946-RA	3	Reactome: R-HSA-2408508;Reactome: R-HSA-1614558;Reactome: R-HSA-1614603	"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Degradation of cysteine and homocysteine";"Cysteine formation from homocysteine"
Mdes004400-RA	8	MetaCyc: PWY-7573;MetaCyc: PWY-66;KEGG: 00520+4.2.1.47;Reactome: R-HSA-6787639;MetaCyc: PWY-5738;MetaCyc: PWY-5740;KEGG: 00051+4.2.1.47;MetaCyc: PWY-5739	"GDP-mycosamine biosynthesis";"GDP-L-fucose biosynthesis I (from GDP-D-mannose)";"Amino sugar and nucleotide sugar metabolism";"GDP-fucose biosynthesis";"GDP-6-deoxy-D-talose biosynthesis";"GDP-L-colitose biosynthesis";"Fructose and mannose metabolism";"GDP-D-perosamine biosynthesis"
Mdes007464-RA	4	Reactome: R-HSA-6802952;Reactome: R-HSA-6798695;Reactome: R-HSA-983168;Reactome: R-HSA-1632852	"Signaling by BRAF and RAF fusions";"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Macroautophagy"
Mdes006965-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes017261-RA	16	Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-176409;Reactome: R-HSA-174084;Reactome: R-HSA-141430;Reactome: R-HSA-174154;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-2559582;Reactome: R-HSA-176412;Reactome: R-HSA-8853884;Reactome: R-HSA-179409;Reactome: R-HSA-983168;Reactome: R-HSA-2467813	"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Autodegradation of Cdh1 by Cdh1:APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Senescence-Associated Secretory Phenotype (SASP)";"Phosphorylation of the APC/C";"Transcriptional Regulation by VENTX";"APC-Cdc20 mediated degradation of Nek2A";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids"
Mdes010553-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Mdes004717-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes013557-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes001760-RA	2	MetaCyc: PWY-6981;KEGG: 00520+2.4.1.16	"Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism"
Mdes018472-RA	10	MetaCyc: PWY-8001;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-5826;MetaCyc: PWY-7112;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-6842;MetaCyc: PWY-7559	"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"Hypoglycin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Glutathione-mediated detoxification II";"Glutathione degradation (DUG pathway"
Mdes015071-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Mdes008909-RA	12	MetaCyc: PWY-601;MetaCyc: PWY-6309;MetaCyc: PWY-6936;KEGG: 00450+4.4.1.13;MetaCyc: PWY-1187;Reactome: R-HSA-71240;MetaCyc: PWY-6842;KEGG: 00380+2.6.1.7;MetaCyc: PWY-801;MetaCyc: PWY-2821;KEGG: 00270+4.4.1.13;MetaCyc: PWY-7901	"Glucosinolate biosynthesis from tryptophan";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Seleno-amino acid biosynthesis (plants)";"Selenocompound metabolism";"Glucosinolate biosynthesis from homomethionine";"Tryptophan catabolism";"Glutathione-mediated detoxification II";"Tryptophan metabolism";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from phenylalanine";"Cysteine and methionine metabolism";"Glucosinolate biosynthesis from tyrosine"
Mdes013769-RA	13	MetaCyc: PWY-5913;Reactome: R-HSA-71403;MetaCyc: PWY-5690;MetaCyc: PWY-6728;KEGG: 00660+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5538;MetaCyc: PWY-5537;KEGG: 00020+6.2.1.5;KEGG: 00720+6.2.1.5;MetaCyc: PWY-6969;MetaCyc: PWY-7384;MetaCyc: PWY-5392	"Partial TCA cycle (obligate autotrophs)";"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"C5-Branched dibasic acid metabolism";"Propanoate metabolism";"Pyruvate fermentation to acetate VI";"Pyruvate fermentation to acetate V";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Reductive TCA cycle II"
Mdes017724-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes006427-RC	1	Reactome: R-HSA-5676934	"Protein repair"
Mdes000328-RB	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes013701-RB	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
Mdes002939-RB	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Mdes010983-RA	1	KEGG: 04150+2.7.11.24	"mTOR signaling pathway"
Mdes008993-RA	1	Reactome: R-HSA-5657655	"MGMT-mediated DNA damage reversal"
Mdes005163-RA	6	Reactome: R-HSA-2173788;Reactome: R-HSA-8948751;Reactome: R-HSA-8863795;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Downregulation of TGF-beta receptor signaling";"Regulation of PTEN stability and activity";"Downregulation of ERBB2 signaling";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes014169-RA	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
Mdes004913-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes001133-RB	27	Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-3371453;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-159230;Reactome: R-HSA-4551638;Reactome: R-HSA-159231;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-168333;Reactome: R-HSA-170822;Reactome: R-HSA-4615885;Reactome: R-HSA-9609690;Reactome: R-HSA-159227	"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transcriptional regulation by small RNAs";"snRNP Assembly";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA replication proteins";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA"
Mdes008332-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes009022-RA	5	Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-1222556	"Amino acids regulate mTORC1";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Ion channel transport";"ROS and RNS production in phagocytes"
Mdes011017-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
Mdes008239-RA	18	MetaCyc: PWY-7409;Reactome: R-HSA-1482801;MetaCyc: PWY-6803;KEGG: 00591+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482839;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482788;Reactome: R-HSA-1482925;MetaCyc: PWY-8053;MetaCyc: PWY-7417;Reactome: R-HSA-1482922;MetaCyc: PWY-8051	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PS";"Phosphatidylcholine acyl editing";"Linoleic acid metabolism";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Arachidonic acid metabolism";"Acyl chain remodelling of PE";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PC";"Acyl chain remodelling of PG";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PI";"Anandamide biosynthesis I"
Mdes003502-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes011115-RA	10	Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-9013508;Reactome: R-HSA-210744;Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-1912408;Reactome: R-HSA-350054;Reactome: R-HSA-2197563;Reactome: R-HSA-9013695	"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"Pre-NOTCH Transcription and Translation";"Notch-HLH transcription pathway";"NOTCH2 intracellular domain regulates transcription";"NOTCH4 Intracellular Domain Regulates Transcription"
Mdes012006-RA	4	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261;KEGG: 00040+2.7.1.17;Reactome: R-HSA-5661270	"Glycerolipid metabolism";"Glycerol degradation I";"Pentose and glucuronate interconversions";"Formation of xylulose-5-phosphate"
Mdes004055-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes018868-RA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220	"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins"
Mdes009317-RA	11	Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-3371497	"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Mdes000570-RA	3	Reactome: R-HSA-8939243;Reactome: R-HSA-2559580;Reactome: R-HSA-8943724	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Oxidative Stress Induced Senescence";"Regulation of PTEN gene transcription"
Mdes007180-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes013055-RB	19	Reactome: R-HSA-5578775;Reactome: R-HSA-9649948;Reactome: R-HSA-5576892;Reactome: R-HSA-6802946;Reactome: R-HSA-9609736;Reactome: R-HSA-9620244;Reactome: R-HSA-6802955;Reactome: R-HSA-936837;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-438066;Reactome: R-HSA-5673001;Reactome: R-HSA-9617324;Reactome: R-HSA-877300;Reactome: R-HSA-5673000;Reactome: R-HSA-9022692;Reactome: R-HSA-399719;Reactome: R-HSA-111932;Reactome: R-HSA-6802952	"Ion homeostasis";"Signaling downstream of RAS mutants";"Phase 0 - rapid depolarisation";"Signaling by moderate kinase activity BRAF mutants";"Assembly and cell surface presentation of NMDA receptors";"Long-term potentiation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ion transport by P-type ATPases";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Unblocking of NMDA receptors, glutamate binding and activation";"RAF/MAP kinase cascade";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Interferon gamma signaling";"RAF activation";"Regulation of MECP2 expression and activity";"Trafficking of AMPA receptors";"CaMK IV-mediated phosphorylation of CREB";"Signaling by BRAF and RAF fusions"
Mdes007204-RA	3	Reactome: R-HSA-1362409;KEGG: 00860+1.16.3.1;Reactome: R-HSA-1268020	"Mitochondrial iron-sulfur cluster biogenesis";"Porphyrin and chlorophyll metabolism";"Mitochondrial protein import"
Mdes007055-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes006538-RA	3	Reactome: R-HSA-5083635;Reactome: R-HSA-2132295;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"MHC class II antigen presentation";"O-glycosylation of TSR domain-containing proteins"
Mdes010511-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes003276-RA	27	Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-3108214;Reactome: R-HSA-4551638;Reactome: R-HSA-3371453;Reactome: R-HSA-168333;Reactome: R-HSA-159231;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-170822;Reactome: R-HSA-4615885;Reactome: R-HSA-159227;Reactome: R-HSA-9609690	"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of chromatin organization proteins";"Regulation of HSF1-mediated heat shock response";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA replication proteins";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events"
Mdes004155-RA	6	Reactome: R-HSA-5545483;Reactome: R-HSA-5358565;Reactome: R-HSA-5632987;Reactome: R-HSA-6796648;Reactome: R-HSA-5358606;Reactome: R-HSA-912446	"Defective Mismatch Repair Associated With MLH1";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With PMS2";"TP53 Regulates Transcription of DNA Repair Genes";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Meiotic recombination"
Mdes012970-RA	5	MetaCyc: PWY-6906;KEGG: 00520+3.5.99.6;Reactome: R-HSA-70171;MetaCyc: PWY-5514;MetaCyc: PWY-6855	"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"Glycolysis";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Chitin degradation I (archaea)"
Mdes006970-RA	2	Reactome: R-HSA-8854214;Reactome: R-HSA-977225	"TBC/RABGAPs";"Amyloid fiber formation"
Mdes009322-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes008670-RA	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
Mdes004204-RB	3	MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3	"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis";"Galactose metabolism"
Mdes011101-RB	13	KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;Reactome: R-HSA-2424491;Reactome: R-HSA-2871796;Reactome: R-HSA-1855204;Reactome: R-HSA-9027277;MetaCyc: PWY-8052;Reactome: R-HSA-2871809;MetaCyc: PWY-7039;Reactome: R-HSA-2029485;Reactome: R-HSA-202433;MetaCyc: PWY-6351;KEGG: 00562+3.1.4.11	"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"DAP12 signaling";"FCERI mediated MAPK activation";"Synthesis of IP3 and IP4 in the cytosol";"Erythropoietin activates Phospholipase C gamma (PLCG)";"2-arachidonoylglycerol biosynthesis";"FCERI mediated Ca+2 mobilization";"Phosphatidate metabolism, as a signaling molecule";"Role of phospholipids in phagocytosis";"Generation of second messenger molecules";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism"
Mdes009156-RB	3	Reactome: R-HSA-6811434;Reactome: R-HSA-390471;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis";"Kinesins"
Mdes017113-RA	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
Mdes000564-RB	3	Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-5362798	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Release of Hh-Np from the secreting cell"
Mdes007471-RA	12	MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis II";"Plasmalogen degradation";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis I"
Mdes012002-RE	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes008000-RA	2	Reactome: R-HSA-3214815;Reactome: R-HSA-427413	"HDACs deacetylate histones";"NoRC negatively regulates rRNA expression"
Mdes012021-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes008412-RA	6	Reactome: R-HSA-8950505;Reactome: R-HSA-3299685;Reactome: R-HSA-2151201;Reactome: R-HSA-9615017;MetaCyc: PWY-6854;Reactome: R-HSA-8862803	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Detoxification of Reactive Oxygen Species";"Transcriptional activation of mitochondrial biogenesis";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Ethylene biosynthesis III (microbes)";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"
Mdes015233-RA	10	Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-3108214	"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"SUMOylation of DNA damage response and repair proteins"
Mdes010969-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes000872-RA	13	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation"
Mdes004057-RA	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
Mdes006178-RB	1	Reactome: R-HSA-1483148	"Synthesis of PG"
Mdes004478-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes012323-RA	3	Reactome: R-HSA-5626978;Reactome: R-HSA-1660662;Reactome: R-HSA-193681	"TNFR1-mediated ceramide production";"Glycosphingolipid metabolism";"Ceramide signalling"
Mdes011988-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes014709-RA	16	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression"
Mdes017352-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes018666-RA	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
Mdes010574-RA	9	MetaCyc: PWY-6146;Reactome: R-HSA-3371599;KEGG: 00620+6.4.1.1;KEGG: 00720+6.4.1.1;KEGG: 00020+6.4.1.1;Reactome: R-HSA-196780;Reactome: R-HSA-70263;MetaCyc: PWY-8086;MetaCyc: PWY-6142	"Methanobacterium thermoautotrophicum biosynthetic metabolism";"Defective HLCS causes multiple carboxylase deficiency";"Pyruvate metabolism";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Biotin transport and metabolism";"Gluconeogenesis";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
Mdes010265-RA	5	Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-3214815;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606	"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
Mdes000142-RC	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Mdes011247-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Mdes007454-RA	15	Reactome: R-HSA-8853884;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-8936459;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519	"Transcriptional Regulation by VENTX";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression"
Mdes003204-RA	6	Reactome: R-HSA-2426168;Reactome: R-HSA-446199;MetaCyc: PWY-7391;MetaCyc: PWY-922;KEGG: 00900+4.1.1.33;Reactome: R-HSA-191273	"Activation of gene expression by SREBF (SREBP)";"Synthesis of Dolichyl-phosphate";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis"
Mdes001893-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes007875-RA	2	KEGG: 00500+3.2.1.26;KEGG: 00052+3.2.1.26	"Starch and sucrose metabolism";"Galactose metabolism"
Mdes000997-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Mdes004112-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Mdes007694-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes006148-RA	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
Mdes008466-RA	1	MetaCyc: PWY-7379	"Mrna capping II"
Mdes011695-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes005000-RC	12	KEGG: 00565+3.1.1.4;MetaCyc: PWY-8051;KEGG: 00590+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7417;MetaCyc: PWY-6803;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4	"Ether lipid metabolism";"Anandamide biosynthesis I";"Arachidonic acid metabolism";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism"
Mdes011122-RA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706	"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Mdes009774-RA	6	KEGG: 00500+3.2.1.1;KEGG: 00500+2.4.1.18;MetaCyc: PWY-7900;MetaCyc: PWY-622;Reactome: R-HSA-189085;MetaCyc: PWY-5067	"Starch and sucrose metabolism";"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch biosynthesis";"Digestion of dietary carbohydrate";"Glycogen biosynthesis II (from UDP-D-Glucose)"
Mdes008779-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes004218-RB	7	Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-6784531;Reactome: R-HSA-168333;Reactome: R-HSA-1655829;Reactome: R-HSA-203927;Reactome: R-HSA-165054	"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"tRNA processing in the nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"MicroRNA (miRNA) biogenesis";"Rev-mediated nuclear export of HIV RNA"
Mdes003726-RB	7	Reactome: R-HSA-3299685;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877	"Detoxification of Reactive Oxygen Species";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase"
Mdes003854-RA	7	Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-6811434;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-68877	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"COPI-dependent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase"
Mdes014770-RA	7	KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1	"Relaxin signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway"
Mdes009156-RD	3	Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes005002-RB	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
Mdes012455-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Mdes005207-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes013245-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes006230-RB	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
Mdes017068-RA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
Mdes004388-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes020041-RA	1	Reactome: R-HSA-71262	"Carnitine synthesis"
Mdes010379-RB	3	Reactome: R-HSA-6811440;Reactome: R-HSA-8876198;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"RAB GEFs exchange GTP for GDP on RABs";"Intra-Golgi traffic"
Mdes009323-RA	7	Reactome: R-HSA-2660826;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096	"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
Mdes018388-RA	5	MetaCyc: PWY-6470;MetaCyc: PWY-6471;KEGG: 00550+2.4.1.129;MetaCyc: PWY-6385;MetaCyc: PWY-5265	"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Peptidoglycan biosynthesis";"Peptidoglycan biosynthesis III (mycobacteria)";"Peptidoglycan biosynthesis II (staphylococci)"
Mdes004752-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes004660-RA	31	Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-189451;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-3214841;Reactome: R-HSA-159236;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-180910;Reactome: R-HSA-9610379;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;KEGG: 00860+2.5.1.141;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;MetaCyc: PWY-7856;Reactome: R-HSA-168333;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-159230;Reactome: R-HSA-3371453	"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Heme biosynthesis";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"PKMTs methylate histone lysines";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"Vpr-mediated nuclear import of PICs";"HCMV Late Events";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Porphyrin and chlorophyll metabolism";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Heme a biosynthesis";"NEP/NS2 Interacts with the Cellular Export Machinery";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP Dependant Mature mRNA";"Regulation of HSF1-mediated heat shock response"
Mdes001601-RB	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
Mdes010051-RA	56	Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5668541;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-5607764;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858	"Neddylation";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"TNFR2 non-canonical NF-kB pathway";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Hedgehog 'on' state";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CLEC7A (Dectin-1) signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity"
Mdes008970-RA	3	Reactome: R-HSA-6804760;Reactome: R-HSA-2299718;Reactome: R-HSA-3214841	"Regulation of TP53 Activity through Methylation";"Condensation of Prophase Chromosomes";"PKMTs methylate histone lysines"
Mdes003836-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes009563-RA	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
Mdes005149-RA	2	Reactome: R-HSA-168138;Reactome: R-HSA-983231	"Toll Like Receptor 9 (TLR9) Cascade";"Factors involved in megakaryocyte development and platelet production"
Mdes007922-RA	5	Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-917729	"HCMV Late Events";"Budding and maturation of HIV virion";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)"
Mdes014100-RA	7	KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1	"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway"
Mdes017288-RA	5	KEGG: 00290+4.2.1.33;Reactome: R-HSA-917937;KEGG: 00630+4.2.1.3;KEGG: 00720+4.2.1.3;KEGG: 00020+4.2.1.3	"Valine, leucine and isoleucine biosynthesis";"Iron uptake and transport";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)"
Mdes017811-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes012143-RA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Mdes016959-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes000028-RA	6	Reactome: R-HSA-3322077;MetaCyc: PWY-622;MetaCyc: PWY-5067;Reactome: R-HSA-3878781;KEGG: 00500+2.4.1.18;MetaCyc: PWY-7900	"Glycogen synthesis";"Starch biosynthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen storage disease type IV (GBE1)";"Starch and sucrose metabolism";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)"
Mdes004414-RB	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes007787-RA	9	Reactome: R-HSA-167162;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-6807505;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-75953	"RNA Polymerase II HIV Promoter Escape";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA polymerase II transcribes snRNA genes";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation"
Mdes014451-RA	4	Reactome: R-HSA-197264;Reactome: R-HSA-6798695;MetaCyc: PWY-5381;KEGG: 00760+6.3.4.21	"Nicotinamide salvaging";"Neutrophil degranulation";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism"
Mdes001616-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-6784531;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"tRNA processing in the nucleus";"RNA Polymerase II Transcription Termination"
Mdes013237-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Mdes000819-RD	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes007178-RA	12	KEGG: 00920+2.7.1.25;MetaCyc: PWY-6683;MetaCyc: PWY-5278;KEGG: 00230+2.7.1.25;KEGG: 00920+2.7.7.4;Reactome: R-HSA-2408550;Reactome: R-HSA-174362;KEGG: 00230+2.7.7.4;MetaCyc: PWY-5340;MetaCyc: PWY-6932;KEGG: 00261+2.7.7.4;KEGG: 00450+2.7.7.4	"Sulfur metabolism";"Assimilatory sulfate reduction III";"Sulfite oxidation III";"Purine metabolism";"Sulfur metabolism";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Transport and synthesis of PAPS";"Purine metabolism";"Sulfate activation for sulfonation";"Selenate reduction";"Monobactam biosynthesis";"Selenocompound metabolism"
Mdes000819-RC	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes010547-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Mdes016573-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes004258-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes012069-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes004615-RA	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
Mdes006994-RB	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes008465-RA	3	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
Mdes004686-RA	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
Mdes014407-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes001675-RC	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
Mdes003308-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes003928-RB	2	Reactome: R-HSA-162710;KEGG: 00563+3.5.1.89	"Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"
Mdes017562-RA	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
Mdes003140-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
Mdes015467-RA	4	Reactome: R-HSA-446203;Reactome: R-HSA-6798695;Reactome: R-HSA-879415;Reactome: R-HSA-1799339	"Asparagine N-linked glycosylation";"Neutrophil degranulation";"Advanced glycosylation endproduct receptor signaling";"SRP-dependent cotranslational protein targeting to membrane"
Mdes000075-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes009988-RA	7	Reactome: R-HSA-1989781;Reactome: R-HSA-2122947;Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-2644606;Reactome: R-HSA-2173796;Reactome: R-HSA-2894862	"PPARA activates gene expression";"NOTCH1 Intracellular Domain Regulates Transcription";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
Mdes000204-RA	9	MetaCyc: PWY-5743;MetaCyc: PWY-5744;MetaCyc: PWY-7117;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7115;Reactome: R-HSA-1475029;MetaCyc: PWY-5789;MetaCyc: PWY-241	"3-hydroxypropanoate cycle";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Reversible hydration of carbon dioxide";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type"
Mdes015322-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes018436-RA	5	MetaCyc: PWY-6168;MetaCyc: PWY-5523;MetaCyc: PWY-7863;KEGG: 00740+2.7.1.26;Reactome: R-HSA-196843	"Flavin biosynthesis III (fungi)";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Roseoflavin biosynthesis";"Riboflavin metabolism";"Vitamin B2 (riboflavin) metabolism"
Mdes008832-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes019537-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes019203-RA	5	Reactome: R-HSA-196741;Reactome: R-HSA-3359469;Reactome: R-HSA-1614635;Reactome: R-HSA-3359467;Reactome: R-HSA-156581	"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective MTR causes methylmalonic aciduria and homocystinuria type cblG";"Sulfur amino acid metabolism";"Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE";"Methylation"
Mdes014553-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes003148-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes006799-RA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes010387-RB	2	Reactome: R-HSA-5689880;MetaCyc: PWY-7511	"Ub-specific processing proteases";"Protein ubiquitination"
Mdes007788-RA	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
Mdes001933-RB	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
Mdes009189-RA	6	MetaCyc: PWY-7656;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
Mdes001809-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes008688-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes006596-RB	5	Reactome: R-HSA-196807;MetaCyc: PWY-7269;MetaCyc: PWY-5083;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268	"Nicotinate metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
Mdes002541-RC	3	Reactome: R-HSA-3899300;Reactome: R-HSA-4090294;Reactome: R-HSA-3232118	"SUMOylation of transcription cofactors";"SUMOylation of intracellular receptors";"SUMOylation of transcription factors"
Mdes011943-RA	6	Reactome: R-HSA-264642;Reactome: R-HSA-210500;Reactome: R-HSA-181430;Reactome: R-HSA-181429;Reactome: R-HSA-212676;Reactome: R-HSA-388844	"Acetylcholine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases"
Mdes006178-RC	1	Reactome: R-HSA-1483148	"Synthesis of PG"
Mdes009175-RA	5	MetaCyc: PWY-8060;KEGG: 00030+4.1.2.4;Reactome: R-HSA-6798695;MetaCyc: PWY-7180;Reactome: R-HSA-71336	"2-deoxy-D-ribose degradation I";"Pentose phosphate pathway";"Neutrophil degranulation";"2-deoxy-alpha-D-ribose 1-phosphate degradation";"Pentose phosphate pathway"
Mdes009540-RA	9	Reactome: R-HSA-72702;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-5419276	"Ribosomal scanning and start codon recognition";"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Mitochondrial translation termination"
Mdes005715-RA	2	KEGG: 00240+4.2.1.70;MetaCyc: PWY-6019	"Pyrimidine metabolism";"Pseudouridine degradation"
Mdes016385-RA	12	Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-1251985;Reactome: R-HSA-977225;Reactome: R-HSA-193692;Reactome: R-HSA-9013700;Reactome: R-HSA-9013507;Reactome: R-HSA-9017802;Reactome: R-HSA-205043;Reactome: R-HSA-2122948;Reactome: R-HSA-3928665;Reactome: R-HSA-2979096	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Nuclear signaling by ERBB4";"Amyloid fiber formation";"Regulated proteolysis of p75NTR";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"NRIF signals cell death from the nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"EPH-ephrin mediated repulsion of cells";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
Mdes005604-RA	8	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Activation of RAC1";"mTOR signaling pathway";"Human papillomavirus infection"
Mdes005326-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes003510-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes003086-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes013736-RA	7	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection"
Mdes004411-RB	2	Reactome: R-HSA-6796648;Reactome: R-HSA-6783310	"TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway"
Mdes003091-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Mdes000050-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Mdes005278-RA	4	KEGG: 00790+2.8.1.9;Reactome: R-HSA-209968;Reactome: R-HSA-947581;MetaCyc: PWY-5963	"Folate biosynthesis";"Thyroxine biosynthesis";"Molybdenum cofactor biosynthesis";"Thio-molybdenum cofactor biosynthesis"
Mdes016956-RA	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
Mdes002339-RA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
Mdes018607-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes018750-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes002725-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes013937-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes003242-RB	8	MetaCyc: PWY-7921;MetaCyc: PWY-7922;Reactome: R-HSA-5083629;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5173105;MetaCyc: PWY-7979;Reactome: R-HSA-5083633;KEGG: 00514+2.4.1.109	"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Mannose type O-glycan biosynthesis";"O-linked glycosylation";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Other types of O-glycan biosynthesis"
Mdes010796-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Mdes011215-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Mdes007128-RC	7	Reactome: R-HSA-983170;Reactome: R-HSA-381183;Reactome: R-HSA-381070;Reactome: R-HSA-381042;Reactome: R-HSA-3371453;Reactome: R-HSA-114608;Reactome: R-HSA-381033	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"ATF6 (ATF6-alpha) activates chaperone genes";"IRE1alpha activates chaperones";"PERK regulates gene expression";"Regulation of HSF1-mediated heat shock response";"Platelet degranulation";"ATF6 (ATF6-alpha) activates chaperones"
Mdes019891-RA	8	Reactome: R-HSA-70171;KEGG: 00524+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00051+2.7.1.1	"Glycolysis";"Neomycin, kanamycin and gentamicin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Glycolysis / Gluconeogenesis";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Fructose and mannose metabolism"
Mdes006824-RA	3	Reactome: R-HSA-5620922;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"BBSome-mediated cargo-targeting to cilium";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes012724-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Mdes004293-RB	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes007469-RA	5	MetaCyc: PWY-3841;MetaCyc: PWY-2201;Reactome: R-HSA-196757;KEGG: 00720+1.5.1.20;KEGG: 00670+1.5.1.20	"Folate transformations II (plants)";"Folate transformations I";"Metabolism of folate and pterines";"Carbon fixation pathways in prokaryotes";"One carbon pool by folate"
Mdes016704-RA	22	MetaCyc: PWY-6142;MetaCyc: PWY-5384;Reactome: R-HSA-70263;MetaCyc: PWY-622;MetaCyc: PWY-6981;KEGG: 00520+5.3.1.9;MetaCyc: PWY-5054;MetaCyc: PWY-7385;MetaCyc: PWY-3801;MetaCyc: PWY-7238;MetaCyc: PWY-5514;Reactome: R-HSA-6798695;MetaCyc: PWY-7347;Reactome: R-HSA-5628897;MetaCyc: PWY-5659;KEGG: 00030+5.3.1.9;KEGG: 00010+5.3.1.9;MetaCyc: PWY-621;MetaCyc: PWY-8013;Reactome: R-HSA-70171;KEGG: 00500+5.3.1.9;MetaCyc: PWY-6992	"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Sucrose degradation IV (sucrose phosphorylase)";"Gluconeogenesis";"Starch biosynthesis";"Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"D-sorbitol biosynthesis I";"1,3-propanediol biosynthesis (engineered)";"Sucrose degradation II (sucrose synthase)";"Sucrose biosynthesis II";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Neutrophil degranulation";"Sucrose biosynthesis III";"TP53 Regulates Metabolic Genes";"GDP-mannose biosynthesis";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis";"Sucrose degradation III (sucrose invertase)";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Glycolysis";"Starch and sucrose metabolism";"1,5-anhydrofructose degradation"
Mdes019796-RA	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
Mdes003130-RA	6	Reactome: R-HSA-163560;MetaCyc: PWY-6118;MetaCyc: PWY-4261;Reactome: R-HSA-1483166;KEGG: 00564+1.1.5.3;MetaCyc: PWY-6952	"Triglyceride catabolism";"Glycerol-3-phosphate shuttle";"Glycerol degradation I";"Synthesis of PA";"Glycerophospholipid metabolism";"Glycerophosphodiester degradation"
Mdes000719-RA	3	MetaCyc: PWY-2161B;Reactome: R-HSA-6798695;KEGG: 00790+3.4.19.9	"Glutamate removal from folates";"Neutrophil degranulation";"Folate biosynthesis"
Mdes001418-RA	6	Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress"
Mdes011748-RA	4	Reactome: R-HSA-917937;KEGG: 00860+1.14.14.18;Reactome: R-HSA-189483;MetaCyc: PWY-5874	"Iron uptake and transport";"Porphyrin and chlorophyll metabolism";"Heme degradation";"Heme degradation I"
Mdes004634-RA	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
Mdes008308-RB	15	Reactome: R-HSA-73779;Reactome: R-HSA-975957;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-9010553;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-167162;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-5419276	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"Regulation of expression of SLITs and ROBOs";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II HIV Promoter Escape";"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"Mitochondrial translation termination"
Mdes017138-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Mdes003806-RA	18	Reactome: R-HSA-1482801;MetaCyc: PWY-6803;MetaCyc: PWY-7409;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482839;KEGG: 00590+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-1482925;Reactome: R-HSA-1482788;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-8053;MetaCyc: PWY-7417;Reactome: R-HSA-1482922	"Acyl chain remodelling of PS";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Ether lipid metabolism";"Acyl chain remodelling of PE";"Arachidonic acid metabolism";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PG";"Acyl chain remodelling of PC";"Synthesis of PA";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PI"
Mdes016932-RA	7	Reactome: R-HSA-70263;KEGG: 00680+3.1.3.11;KEGG: 00010+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00030+3.1.3.11;KEGG: 00051+3.1.3.11;MetaCyc: PWY-5484	"Gluconeogenesis";"Methane metabolism";"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)"
Mdes011628-RA	8	KEGG: 04660+2.7.10.2;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1	"T cell receptor signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway"
Mdes003816-RA	31	MetaCyc: PWY-6282;MetaCyc: PWY-6799;MetaCyc: PWY-8049;MetaCyc: PWY-5971;MetaCyc: PWY-5147;MetaCyc: PWY-6519;MetaCyc: PWY-6113;MetaCyc: PWY-7388;MetaCyc: PWY-5994;MetaCyc: PWYG-321;MetaCyc: PWY-7746;MetaCyc: PWY-7663;Reactome: R-HSA-75105;MetaCyc: PWY-5366;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7664;MetaCyc: PWY-8047;MetaCyc: PWY-8012;MetaCyc: PWY-5367;MetaCyc: PWY-5966-1;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;Reactome: R-HSA-163765;Reactome: R-HSA-199220;MetaCyc: PWY-5142;MetaCyc: PWY-5973;Reactome: R-HSA-9029558;MetaCyc: PWY-4381;MetaCyc: PWY-5989;MetaCyc: PWY-7858;MetaCyc: PWY-7723;Reactome: R-HSA-2426168	"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Pederin biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Oleate biosynthesis I (plants)";"8-amino-7-oxononanoate biosynthesis I";"Superpathway of mycolate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"";"Mycobacterial sulfolipid biosynthesis";"Gondoate biosynthesis (anaerobic)";"Fatty acyl-CoA biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Biotin metabolism";"Oleate biosynthesis IV (anaerobic)";"Bryostatin biosynthesis";"Mupirocin biosynthesis";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis";"ChREBP activates metabolic gene expression";"Vitamin B5 (pantothenate) metabolism";"Acyl-[acyl-carrier protein] thioesterase pathway";"Cis-vaccenate biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Stearate biosynthesis II (bacteria and plants)";"(5Z)-dodecenoate biosynthesis II";"Bacterial bioluminescence";"Activation of gene expression by SREBF (SREBP)"
Mdes013268-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes014456-RA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
Mdes012844-RA	13	KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;Reactome: R-HSA-2024096;Reactome: R-HSA-4085001;Reactome: R-HSA-2206308;Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-4341670;KEGG: 00600+3.2.1.23;Reactome: R-HSA-1660662;Reactome: R-HSA-2022857	"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"HS-GAG degradation";"Sialic acid metabolism";"MPS IV - Morquio syndrome B";"Neutrophil degranulation";"Other glycan degradation";"Galactose metabolism";"Glycosaminoglycan degradation";"Defective NEU1 causes sialidosis";"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Keratan sulfate degradation"
Mdes006638-RA	19	Reactome: R-HSA-3928662;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-5687128;Reactome: R-HSA-8964616;Reactome: R-HSA-5663220;Reactome: R-HSA-8950505;Reactome: R-HSA-418885;Reactome: R-HSA-5625970;Reactome: R-HSA-114604;Reactome: R-HSA-428543;Reactome: R-HSA-389359;Reactome: R-HSA-525793;Reactome: R-HSA-5626467;Reactome: R-HSA-5627123;Reactome: R-HSA-983231;Reactome: R-HSA-194840;Reactome: R-HSA-182971	"EPHB-mediated forward signaling";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"MAPK6/MAPK4 signaling";"G beta:gamma signalling through CDC42";"RHO GTPases Activate Formins";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"DCC mediated attractive signaling";"RHO GTPases activate KTN1";"GPVI-mediated activation cascade";"Inactivation of CDC42 and RAC1";"CD28 dependent Vav1 pathway";"Myogenesis";"RHO GTPases activate IQGAPs";"RHO GTPases activate PAKs";"Factors involved in megakaryocyte development and platelet production";"Rho GTPase cycle";"EGFR downregulation"
Mdes017009-RA	2	Reactome: R-HSA-8876725;Reactome: R-HSA-611105	"Protein methylation";"Respiratory electron transport"
Mdes015743-RA	2	Reactome: R-HSA-6783984;KEGG: 00260+1.4.4.2	"Glycine degradation";"Glycine, serine and threonine metabolism"
Mdes002306-RA	6	Reactome: R-HSA-73856;Reactome: R-HSA-191859;Reactome: R-HSA-111367;Reactome: R-HSA-72163;Reactome: R-HSA-77588;Reactome: R-HSA-72165	"RNA Polymerase II Transcription Termination";"snRNP Assembly";"SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Major Pathway";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"mRNA Splicing - Minor Pathway"
Mdes006128-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes006632-RB	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes017723-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes001332-RA	57	Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-6798695;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-187577;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-5668541;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050	"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"Ub-specific processing proteases";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"Neutrophil degranulation";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"SCF(Skp2)-mediated degradation of p27/p21";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"TNFR2 non-canonical NF-kB pathway";"Neddylation";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"
Mdes001093-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes002411-RA	3	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.14;Reactome: R-HSA-379726	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
Mdes005701-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-159231;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes001176-RA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
Mdes000518-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes003670-RA	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
Mdes006400-RA	3	KEGG: 00511+3.2.1.45;Reactome: R-HSA-1660662;KEGG: 00600+3.2.1.45	"Other glycan degradation";"Glycosphingolipid metabolism";"Sphingolipid metabolism"
Mdes002237-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
Mdes008263-RA	4	Reactome: R-HSA-611105;Reactome: R-HSA-77289;Reactome: R-HSA-389661;Reactome: R-HSA-6799198	"Respiratory electron transport";"Mitochondrial Fatty Acid Beta-Oxidation";"Glyoxylate metabolism and glycine degradation";"Complex I biogenesis"
Mdes007414-RB	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes016354-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
Mdes016932-RD	7	Reactome: R-HSA-70263;KEGG: 00680+3.1.3.11;KEGG: 00010+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00030+3.1.3.11;KEGG: 00051+3.1.3.11;MetaCyc: PWY-5484	"Gluconeogenesis";"Methane metabolism";"Glycolysis / Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)"
Mdes016184-RA	29	Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-73772;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-5696400;Reactome: R-HSA-427413;Reactome: R-HSA-5696395;Reactome: R-HSA-113418;Reactome: R-HSA-167246;Reactome: R-HSA-167162;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-77075;Reactome: R-HSA-73779	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase I Promoter Escape";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"HIV Transcription Initiation";"Dual incision in TC-NER";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"Dual Incision in GG-NER";"NoRC negatively regulates rRNA expression";"Formation of Incision Complex in GG-NER";"Formation of the Early Elongation Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II HIV Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
Mdes015451-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes002866-RA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Mdes007402-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes010105-RD	2	Reactome: R-HSA-975956;Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes008999-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes005432-RC	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Mdes008600-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes005757-RA	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
Mdes016486-RA	6	MetaCyc: PWY-4381;MetaCyc: PWY-5789;MetaCyc: PWY-6722;Reactome: R-HSA-196780;MetaCyc: PWY-5743;MetaCyc: PWY-5744	"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Candicidin biosynthesis";"Biotin transport and metabolism";"3-hydroxypropanoate cycle";"Glyoxylate assimilation"
Mdes001330-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-8869496	"rRNA modification in the nucleus and cytosol";"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"
Mdes012079-RA	3	Reactome: R-HSA-75109;MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Triglyceride biosynthesis";"Glycerol degradation I";"Glycerolipid metabolism"
Mdes016347-RB	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes019262-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes010340-RA	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
Mdes013900-RA	2	KEGG: 00770+6.3.2.5;Reactome: R-HSA-196783	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
Mdes009284-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes012704-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes003986-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Mdes002567-RB	4	Reactome: R-HSA-6790901;Reactome: R-HSA-611105;Reactome: R-HSA-6791226;Reactome: R-HSA-6799198	"rRNA modification in the nucleus and cytosol";"Respiratory electron transport";"Major pathway of rRNA processing in the nucleolus and cytosol";"Complex I biogenesis"
Mdes007876-RA	16	Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689	"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits"
Mdes005626-RA	3	Reactome: R-HSA-6804115;Reactome: R-HSA-5617472;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deadenylation of mRNA"
Mdes002470-RA	6	KEGG: 00010+5.4.2.11;KEGG: 00680+5.4.2.11;MetaCyc: PWY-5484;MetaCyc: PWY-1622;MetaCyc: PWY-8004;KEGG: 00260+5.4.2.11	"Glycolysis / Gluconeogenesis";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation I (serine pathway)";"Entner-Doudoroff pathway I";"Glycine, serine and threonine metabolism"
Mdes002509-RA	14	MetaCyc: PWY-7725;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-8041;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7035;MetaCyc: PWY-7724;MetaCyc: PWY-6598	"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Fatty acid elongation";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Sciadonate biosynthesis"
Mdes004869-RB	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Mdes000667-RB	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
Mdes002515-RA	13	Reactome: R-HSA-437239;Reactome: R-HSA-8866427;Reactome: R-HSA-5140745;Reactome: R-HSA-8856825;Reactome: R-HSA-167590;Reactome: R-HSA-5099900;Reactome: R-HSA-8964038;Reactome: R-HSA-177504;Reactome: R-HSA-2132295;Reactome: R-HSA-182218;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-8856828	"Recycling pathway of L1";"VLDLR internalisation and degradation";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Cargo recognition for clathrin-mediated endocytosis";"Nef Mediated CD4 Down-regulation";"WNT5A-dependent internalization of FZD4";"LDL clearance";"Retrograde neurotrophin signalling";"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"Clathrin-mediated endocytosis"
Mdes008259-RA	18	MetaCyc: PWY-7416;KEGG: 00591+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482839;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-6803;Reactome: R-HSA-1482801;Reactome: R-HSA-1482922;MetaCyc: PWY-7417;MetaCyc: PWY-8053;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1483166;Reactome: R-HSA-1482925	"Phospholipid remodeling (phosphatidylcholine, yeast)";"Linoleic acid metabolism";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Acyl chain remodelling of PE";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PS";"Acyl chain remodelling of PI";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Glycerophospholipid metabolism";"Synthesis of PA";"Acyl chain remodelling of PG"
Mdes002787-RA	1	Reactome: R-HSA-419771	"Opsins"
Mdes012161-RA	33	Reactome: R-HSA-165054;Reactome: R-HSA-2467813;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-141444;Reactome: R-HSA-5619107;Reactome: R-HSA-170822;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-168333;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-2500257;Reactome: R-HSA-180910;Reactome: R-HSA-4085377;Reactome: R-HSA-180746;Reactome: R-HSA-9648025;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-3108214;Reactome: R-HSA-5663220;Reactome: R-HSA-4551638;Reactome: R-HSA-159231	"Rev-mediated nuclear export of HIV RNA";"Separation of Sister Chromatids";"HCMV Late Events";"ISG15 antiviral mechanism";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"NEP/NS2 Interacts with the Cellular Export Machinery";"snRNP Assembly";"Transcriptional regulation by small RNAs";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"Resolution of Sister Chromatid Cohesion";"Vpr-mediated nuclear import of PICs";"SUMOylation of SUMOylation proteins";"Nuclear import of Rev protein";"EML4 and NUDC in mitotic spindle formation";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Mitotic Prometaphase";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA damage response and repair proteins";"RHO GTPases Activate Formins";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA Derived from an Intronless Transcript"
Mdes007447-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes000501-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes008319-RC	3	Reactome: R-HSA-1358803;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes006387-RB	5	Reactome: R-HSA-159231;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-72163	"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway"
Mdes006752-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes005927-RB	4	Reactome: R-HSA-1632852;Reactome: R-HSA-936440;Reactome: R-HSA-8934903;Reactome: R-HSA-5205685	"Macroautophagy";"Negative regulators of DDX58/IFIH1 signaling";"Receptor Mediated Mitophagy";"Pink/Parkin Mediated Mitophagy"
Mdes003787-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes011202-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes015683-RA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-72649	"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation"
Mdes006348-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes003633-RA	5	Reactome: R-HSA-9649948;Reactome: R-HSA-6802955;Reactome: R-HSA-6802946;Reactome: R-HSA-5675221;Reactome: R-HSA-5673000	"Signaling downstream of RAS mutants";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by moderate kinase activity BRAF mutants";"Negative regulation of MAPK pathway";"RAF activation"
Mdes003943-RA	4	Reactome: R-HSA-72203;Reactome: R-HSA-4570464;Reactome: R-HSA-72163;Reactome: R-HSA-9610379	"Processing of Capped Intron-Containing Pre-mRNA";"SUMOylation of RNA binding proteins";"mRNA Splicing - Major Pathway";"HCMV Late Events"
Mdes001742-RA	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
Mdes004463-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Mdes017894-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes007814-RA	8	Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-2151209;Reactome: R-HSA-9613354;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-380972;Reactome: R-HSA-6804756	"TP53 Regulates Metabolic Genes";"Macroautophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Lipophagy";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of TP53 Activity through Phosphorylation"
Mdes005802-RA	30	KEGG: 04926+2.7.11.1;Reactome: R-HSA-198693;Reactome: R-HSA-389513;Reactome: R-HSA-5628897;Reactome: R-HSA-5218920;Reactome: R-HSA-8876198;Reactome: R-HSA-8948751;Reactome: R-HSA-5674400;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6804757;Reactome: R-HSA-198323;Reactome: R-HSA-9634638;KEGG: 05165+2.7.11.1;Reactome: R-HSA-69656;KEGG: 04714+2.7.11.1;Reactome: R-HSA-392451;Reactome: R-HSA-9614399;Reactome: R-HSA-69202;Reactome: R-HSA-1257604;KEGG: 05163+2.7.11.1;Reactome: R-HSA-389357;KEGG: 04151+2.7.11.1;Reactome: R-HSA-1358803;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6804759;Reactome: R-HSA-211163;Reactome: R-HSA-8941332;Reactome: R-HSA-6804758;Reactome: R-HSA-111447;Reactome: R-HSA-199418	"Relaxin signaling pathway";"AKT phosphorylates targets in the nucleus";"CTLA4 inhibitory signaling";"TP53 Regulates Metabolic Genes";"VEGFR2 mediated vascular permeability";"RAB GEFs exchange GTP for GDP on RABs";"Regulation of PTEN stability and activity";"Constitutive Signaling by AKT1 E17K in Cancer";"mTOR signaling pathway";"Regulation of TP53 Degradation";"AKT phosphorylates targets in the cytosol";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Human papillomavirus infection";"Cyclin A:Cdk2-associated events at S phase entry";"Thermogenesis";"G beta:gamma signalling through PI3Kgamma";"Regulation of localization of FOXO transcription factors";"Cyclin E associated events during G1/S transition";"PIP3 activates AKT signaling";"Human cytomegalovirus infection";"CD28 dependent PI3K/Akt signaling";"PI3K-Akt signaling pathway";"Downregulation of ERBB2:ERBB3 signaling";"Human immunodeficiency virus 1 infection";"Regulation of TP53 Activity through Association with Co-factors";"AKT-mediated inactivation of FOXO1A";"RUNX2 regulates genes involved in cell migration";"Regulation of TP53 Activity through Acetylation";"Activation of BAD and translocation to mitochondria";"Negative regulation of the PI3K/AKT network"
Mdes004403-RA	4	Reactome: R-HSA-422085;Reactome: R-HSA-381771;Reactome: R-HSA-400511;Reactome: R-HSA-1799339	"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane"
Mdes009575-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes018259-RA	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
Mdes008091-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes001466-RB	5	Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-1445148;Reactome: R-HSA-75035;Reactome: R-HSA-5628897	"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes"
Mdes008140-RD	7	KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1	"Relaxin signaling pathway";"Thermogenesis";"mTOR signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway"
Mdes000793-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes016572-RD	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Mdes004109-RA	3	Reactome: R-HSA-2022928;MetaCyc: PWY-6558;KEGG: 00534+5.1.3.17	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin"
Mdes010387-RC	2	Reactome: R-HSA-5689880;MetaCyc: PWY-7511	"Ub-specific processing proteases";"Protein ubiquitination"
Mdes000920-RC	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes012207-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes016494-RA	2	Reactome: R-HSA-8876725;Reactome: R-HSA-611105	"Protein methylation";"Respiratory electron transport"
Mdes000819-RB	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes006032-RA	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
Mdes018888-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Mdes001363-RA	2	Reactome: R-HSA-5619061;Reactome: R-HSA-425397	"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)";"Transport of vitamins, nucleosides, and related molecules"
Mdes014201-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes002965-RA	18	MetaCyc: PWY-7176;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7227;Reactome: R-HSA-499943;MetaCyc: PWY-7184;MetaCyc: PWY-7220;MetaCyc: PWY-7224;MetaCyc: PWY-7221;MetaCyc: PWY-7226;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7210;MetaCyc: PWY-7205;MetaCyc: PWY-7187;MetaCyc: PWY-6545;MetaCyc: PWY-7198;MetaCyc: PWY-7222;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7197	"UTP and CTP de novo biosynthesis";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine deoxyribonucleosides salvage";"Guanosine ribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"CMP phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotide phosphorylation"
Mdes003726-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Mdes018444-RA	2	Reactome: R-HSA-4549349;Reactome: R-HSA-446193	"Defective ALG2 causes ALG2-CDG (CDG-1i)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
Mdes009204-RA	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
Mdes013937-RB	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes007818-RA	29	Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-72086;Reactome: R-HSA-167152;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-167158;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-73772;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-77075;Reactome: R-HSA-76042;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-73762;Reactome: R-HSA-112382;Reactome: R-HSA-5696395;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-427413;Reactome: R-HSA-5696400;Reactome: R-HSA-73776;Reactome: R-HSA-75953	"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"Dual incision in TC-NER";"mRNA Capping";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of the HIV-1 Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Promoter Escape";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase I Transcription Initiation";"Formation of RNA Pol II elongation complex";"Formation of Incision Complex in GG-NER";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"NoRC negatively regulates rRNA expression";"Dual Incision in GG-NER";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation"
Mdes000313-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes008532-RA	9	Reactome: R-HSA-70268;KEGG: 00010+1.1.1.27;KEGG: 00620+1.1.1.27;MetaCyc: PWY-6901;Reactome: R-HSA-6798695;KEGG: 00270+1.1.1.27;KEGG: 00640+1.1.1.27;MetaCyc: PWY-5481;MetaCyc: PWY-8086	"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation";"Neutrophil degranulation";"Cysteine and methionine metabolism";"Propanoate metabolism";"Pyruvate fermentation to (S)-lactate";"(S)-lactate fermentation to propanoate, acetate and hydrogen"
Mdes014350-RA	5	Reactome: R-HSA-8949613;Reactome: R-HSA-611105;Reactome: R-HSA-163210;Reactome: R-HSA-5628897;Reactome: R-HSA-6799198	"Cristae formation";"Respiratory electron transport";"Formation of ATP by chemiosmotic coupling";"TP53 Regulates Metabolic Genes";"Complex I biogenesis"
Mdes012278-RA	3	Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434	"Kinesins";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes008342-RB	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
Mdes001391-RA	6	Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-69052	"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA";"Switching of origins to a post-replicative state"
Mdes000665-RA	3	MetaCyc: PWY-6689;MetaCyc: PWY-7803;Reactome: R-HSA-6784531	"Trna splicing I";"Trna splicing II";"tRNA processing in the nucleus"
Mdes006733-RA	13	Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes005608-RA	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
Mdes006806-RA	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
Mdes012413-RA	11	MetaCyc: PWY-6549;MetaCyc: PWY-381;KEGG: 00910+6.3.1.2;KEGG: 00220+6.3.1.2;MetaCyc: PWY-5675;KEGG: 00250+6.3.1.2;KEGG: 00630+6.3.1.2;MetaCyc: PWY-6963;Reactome: R-HSA-210455;MetaCyc: PWY-6964;Reactome: R-HSA-8964539	"L-glutamine biosynthesis III";"Nitrate reduction II (assimilatory)";"Nitrogen metabolism";"Arginine biosynthesis";"Nitrate reduction V (assimilatory)";"Alanine, aspartate and glutamate metabolism";"Glyoxylate and dicarboxylate metabolism";"Ammonia assimilation cycle I";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Ammonia assimilation cycle II";"Glutamate and glutamine metabolism"
Mdes003528-RA	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
Mdes004384-RC	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6785470	"tRNA processing in the nucleus";"tRNA processing in the mitochondrion"
Mdes009170-RA	4	Reactome: R-HSA-3899300;Reactome: R-HSA-9613829;Reactome: R-HSA-9646399;Reactome: R-HSA-9615710	"SUMOylation of transcription cofactors";"Chaperone Mediated Autophagy";"Aggrephagy";"Late endosomal microautophagy"
Mdes008774-RA	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
Mdes011122-RC	13	Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes010318-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes000195-RB	5	Reactome: R-HSA-6798695;Reactome: R-HSA-6811440;Reactome: R-HSA-8856825;Reactome: R-HSA-432722;Reactome: R-HSA-8856828	"Neutrophil degranulation";"Retrograde transport at the Trans-Golgi-Network";"Cargo recognition for clathrin-mediated endocytosis";"Golgi Associated Vesicle Biogenesis";"Clathrin-mediated endocytosis"
Mdes005712-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes009147-RA	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
Mdes004005-RA	7	Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-73980	"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination"
Mdes003550-RA	4	KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;Reactome: R-HSA-499943	"Thiamine metabolism";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates"
Mdes000779-RA	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis"
Mdes008182-RA	4	MetaCyc: PWY-6987;KEGG: 00785+2.8.1.8;MetaCyc: PWY-7382;Reactome: R-HSA-389661	"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Glyoxylate metabolism and glycine degradation"
Mdes013885-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes010545-RA	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Mdes014151-RB	2	Reactome: R-HSA-8873719;Reactome: R-HSA-6803205	"RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"
Mdes009849-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes003683-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes001995-RC	2	Reactome: R-HSA-6798695;MetaCyc: PWY-7511	"Neutrophil degranulation";"Protein ubiquitination"
Mdes000747-RB	12	Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-167200;Reactome: R-HSA-112382;Reactome: R-HSA-167152;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-6804756;Reactome: R-HSA-167287	"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of RNA Pol II elongation complex";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Regulation of TP53 Activity through Phosphorylation";"HIV elongation arrest and recovery"
Mdes010296-RA	13	Reactome: R-HSA-5358346;Reactome: R-HSA-8866654;Reactome: R-HSA-5689896;Reactome: R-HSA-9646399;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-382556;Reactome: R-HSA-110320;Reactome: R-HSA-8876725;Reactome: R-HSA-6798695;Reactome: R-HSA-3371511;Reactome: R-HSA-532668;Reactome: R-HSA-5689877	"Hedgehog ligand biogenesis";"E3 ubiquitin ligases ubiquitinate target proteins";"Ovarian tumor domain proteases";"Aggrephagy";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport";"Translesion Synthesis by POLH";"Protein methylation";"Neutrophil degranulation";"HSF1 activation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Josephin domain DUBs"
Mdes009804-RB	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
Mdes001313-RB	3	Reactome: R-HSA-5578775;Reactome: R-HSA-425561;Reactome: R-HSA-418359	"Ion homeostasis";"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels"
Mdes015458-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Mdes000357-RA	1	KEGG: 00860+4.4.1.17	"Porphyrin and chlorophyll metabolism"
Mdes014836-RA	4	KEGG: 00640+1.2.1.27;Reactome: R-HSA-70895;MetaCyc: PWY-5642;KEGG: 00280+1.2.1.27	"Propanoate metabolism";"Branched-chain amino acid catabolism";"2,4-dinitrotoluene degradation";"Valine, leucine and isoleucine degradation"
Mdes011191-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Mdes008627-RA	13	Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-2408557	"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis"
Mdes009169-RB	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes010463-RB	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes010439-RB	6	Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450604	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA"
Mdes005396-RB	3	KEGG: 00460+3.5.1.1;KEGG: 00250+3.5.1.1;Reactome: R-HSA-8963693	"Cyanoamino acid metabolism";"Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism"
Mdes001552-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Mdes017253-RA	6	Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450513	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
Mdes002050-RC	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes015780-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes011121-RC	3	Reactome: R-HSA-114608;Reactome: R-HSA-8957275;Reactome: R-HSA-381426	"Platelet degranulation";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
Mdes000120-RB	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes011937-RB	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes003770-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes014848-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes003214-RA	4	Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712	"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport"
Mdes020059-RA	2	Reactome: R-HSA-5362517;Reactome: R-HSA-204174	"Signaling by Retinoic Acid";"Regulation of pyruvate dehydrogenase (PDH) complex"
Mdes017351-RA	3	Reactome: R-HSA-1660662;Reactome: R-HSA-5626978;Reactome: R-HSA-193681	"Glycosphingolipid metabolism";"TNFR1-mediated ceramide production";"Ceramide signalling"
Mdes003301-RA	6	MetaCyc: PWY-5381;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1;Reactome: R-HSA-196807;MetaCyc: PWY-7761;KEGG: 00760+6.3.1.5	"Pyridine nucleotide cycling (plants)";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism"
Mdes018007-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Mdes006630-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Mdes014569-RA	18	MetaCyc: PWY-7197;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7222;MetaCyc: PWY-7198;MetaCyc: PWY-7210;MetaCyc: PWY-7187;MetaCyc: PWY-6545;MetaCyc: PWY-7205;MetaCyc: PWY-7226;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7221;MetaCyc: PWY-7224;MetaCyc: PWY-7220;MetaCyc: PWY-7227;MetaCyc: PWY-7184;Reactome: R-HSA-499943;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7176	"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"CMP phosphorylation";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Purine deoxyribonucleosides salvage";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Drug metabolism - other enzymes";"UTP and CTP de novo biosynthesis"
Mdes011597-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes019722-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes001423-RA	1	Reactome: R-HSA-8964572	"Lipid particle organization"
Mdes004752-RB	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes001426-RA	16	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes009539-RC	7	Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380320	"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes"
Mdes018075-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Mdes015430-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes003504-RC	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes005764-RA	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
Mdes004255-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes019785-RA	8	KEGG: 00140+5.3.3.1;MetaCyc: PWY-6948;MetaCyc: PWY-7299;MetaCyc: PWY-6946;MetaCyc: PWY-6945;MetaCyc: PWY-2582;KEGG: 00984+5.3.3.1;MetaCyc: PWY-699	"Steroid hormone biosynthesis";"Sitosterol degradation to androstenedione";"Progesterone biosynthesis";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Brassinosteroid biosynthesis II";"Steroid degradation";"Brassinosteroid biosynthesis I"
Mdes005781-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-6783310	"Protein ubiquitination";"Fanconi Anemia Pathway"
Mdes006351-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Mdes006434-RA	14	MetaCyc: PWY-6598;MetaCyc: PWY-7035;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;Reactome: R-HSA-75876;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-6433;MetaCyc: PWY-7725;MetaCyc: PWY-7602;MetaCyc: PWY-5972	"Sciadonate biosynthesis";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)"
Mdes006762-RA	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
Mdes001136-RA	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
Mdes006617-RA	2	Reactome: R-HSA-1799339;Reactome: R-HSA-381038	"SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes"
Mdes013794-RA	1	Reactome: R-HSA-212300	"PRC2 methylates histones and DNA"
Mdes009539-RG	7	Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes"
Mdes010871-RA	4	Reactome: R-HSA-446193;Reactome: R-HSA-4720475;KEGG: 00513+2.4.1.258;KEGG: 00510+2.4.1.258	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG3 causes ALG3-CDG (CDG-1d)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
Mdes011885-RA	11	KEGG: 00240+3.1.3.5;MetaCyc: PWY-6607;KEGG: 00230+3.1.3.5;MetaCyc: PWY-5381;MetaCyc: PWY-6608;MetaCyc: PWY-6606;KEGG: 00760+3.1.3.5;MetaCyc: PWY-5695;MetaCyc: PWY-7821;MetaCyc: PWY-6596;MetaCyc: PWY-7185	"Pyrimidine metabolism";"Guanosine nucleotides degradation I";"Purine metabolism";"Pyridine nucleotide cycling (plants)";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Nicotinate and nicotinamide metabolism";"Inosine 5'-phosphate degradation";"Tunicamycin biosynthesis";"Adenosine nucleotides degradation I";"UTP and CTP dephosphorylation I"
Mdes013409-RA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Mdes014578-RA	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.4	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes003736-RA	17	Reactome: R-HSA-9665233;Reactome: R-HSA-8983711;Reactome: R-HSA-8863795;Reactome: R-HSA-9665251;Reactome: R-HSA-9665247;Reactome: R-HSA-9664565;Reactome: R-HSA-9665250;Reactome: R-HSA-9665244;Reactome: R-HSA-9652282;Reactome: R-HSA-5637810;Reactome: R-HSA-9665249;Reactome: R-HSA-1227986;Reactome: R-HSA-1236382;Reactome: R-HSA-9665245;Reactome: R-HSA-909733;Reactome: R-HSA-9634285;Reactome: R-HSA-9665246	"Resistance of ERBB2 KD mutants to trastuzumab";"OAS antiviral response";"Downregulation of ERBB2 signaling";"Resistance of ERBB2 KD mutants to lapatinib";"Resistance of ERBB2 KD mutants to osimertinib";"Signaling by ERBB2 KD Mutants";"Resistance of ERBB2 KD mutants to AEE788";"Resistance of ERBB2 KD mutants to sapitinib";"Drug-mediated inhibition of ERBB2 signaling";"Constitutive Signaling by EGFRvIII";"Resistance of ERBB2 KD mutants to afatinib";"Signaling by ERBB2";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Resistance of ERBB2 KD mutants to tesevatinib";"Interferon alpha/beta signaling";"Constitutive Signaling by Overexpressed ERBB2";"Resistance of ERBB2 KD mutants to neratinib"
Mdes004256-RA	20	Reactome: R-HSA-110312;Reactome: R-HSA-110320;Reactome: R-HSA-69091;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-5693616;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938;Reactome: R-HSA-5651801;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-5656121;Reactome: R-HSA-6804756;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-5693607	"Translesion synthesis by REV1";"Translesion Synthesis by POLH";"Polymerase switching";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"Translesion synthesis by POLI";"Regulation of TP53 Activity through Phosphorylation";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends"
Mdes011933-RA	5	Reactome: R-HSA-5358346;Reactome: R-HSA-381038;Reactome: R-HSA-5362768;MetaCyc: PWY-7511;Reactome: R-HSA-901032	"Hedgehog ligand biogenesis";"XBP1(S) activates chaperone genes";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Protein ubiquitination";"ER Quality Control Compartment (ERQC)"
Mdes012235-RA	28	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-1912408;Reactome: R-HSA-1799339;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-2408557;Reactome: R-HSA-5628897;Reactome: R-HSA-72689;Reactome: R-HSA-8936459;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-8948700;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-2559580;Reactome: R-HSA-72764;Reactome: R-HSA-8943723;Reactome: R-HSA-8986944;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-8853884	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Pre-NOTCH Transcription and Translation";"SRP-dependent cotranslational protein targeting to membrane";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Selenocysteine synthesis";"TP53 Regulates Metabolic Genes";"Formation of a pool of free 40S subunits";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Oxidative Stress Induced Senescence";"Eukaryotic Translation Termination";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by MECP2";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Transcriptional Regulation by VENTX"
Mdes004023-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Mdes004721-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes000470-RB	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes012483-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes010179-RA	11	MetaCyc: PWY-381;KEGG: 00910+6.3.1.2;MetaCyc: PWY-6549;KEGG: 00220+6.3.1.2;KEGG: 00250+6.3.1.2;MetaCyc: PWY-5675;KEGG: 00630+6.3.1.2;MetaCyc: PWY-6963;Reactome: R-HSA-210455;MetaCyc: PWY-6964;Reactome: R-HSA-8964539	"Nitrate reduction II (assimilatory)";"Nitrogen metabolism";"L-glutamine biosynthesis III";"Arginine biosynthesis";"Alanine, aspartate and glutamate metabolism";"Nitrate reduction V (assimilatory)";"Glyoxylate and dicarboxylate metabolism";"Ammonia assimilation cycle I";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Ammonia assimilation cycle II";"Glutamate and glutamine metabolism"
Mdes014222-RA	22	Reactome: R-HSA-176412;Reactome: R-HSA-8853884;Reactome: R-HSA-179409;MetaCyc: PWY-7077;Reactome: R-HSA-446210;MetaCyc: PWY-7395;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-141430;KEGG: 00520+3.5.1.25;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;MetaCyc: PWY-6906;KEGG: 00052+3.5.1.25;Reactome: R-HSA-176408;Reactome: R-HSA-174154;Reactome: R-HSA-174048	"Phosphorylation of the APC/C";"Transcriptional Regulation by VENTX";"APC-Cdc20 mediated degradation of Nek2A";"N-acetyl-D-galactosamine degradation";"Synthesis of UDP-N-acetyl-glucosamine";"D-galactosamine and N-acetyl-D-galactosamine degradation";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Amino sugar and nucleotide sugar metabolism";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"Chitin derivatives degradation";"Galactose metabolism";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdc20 mediated degradation of Cyclin B"
Mdes000940-RA	8	Reactome: R-HSA-68689;Reactome: R-HSA-68949;Reactome: R-HSA-113507;Reactome: R-HSA-68827;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68616;Reactome: R-HSA-68962	"CDC6 association with the ORC:origin complex";"Orc1 removal from chromatin";"E2F-enabled inhibition of pre-replication complex formation";"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex"
Mdes016635-RA	3	MetaCyc: PWY-6700;MetaCyc: PWY-8106;Reactome: R-HSA-6782315	"Queuosine biosynthesis I (de novo)";"Queuosine biosynthesis III (queuosine salvage)";"tRNA modification in the nucleus and cytosol"
Mdes009303-RA	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
Mdes011010-RA	7	Reactome: R-HSA-5674400;Reactome: R-HSA-5628897;Reactome: R-HSA-8854214;Reactome: R-HSA-198323;Reactome: R-HSA-165181;Reactome: R-HSA-380972;Reactome: R-HSA-1632852	"Constitutive Signaling by AKT1 E17K in Cancer";"TP53 Regulates Metabolic Genes";"TBC/RABGAPs";"AKT phosphorylates targets in the cytosol";"Inhibition of TSC complex formation by PKB";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy"
Mdes004451-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes009174-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes017847-RA	5	MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00561+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22	"Stachyose degradation";"Galactose metabolism";"Glycerolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism"
Mdes006230-RC	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
Mdes004382-RA	5	Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-68949	"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex";"Unwinding of DNA";"Orc1 removal from chromatin"
Mdes011262-RA	5	Reactome: R-HSA-5620922;Reactome: R-HSA-5635838;Reactome: R-HSA-373080;Reactome: R-HSA-5632684;Reactome: R-HSA-5610787	"BBSome-mediated cargo-targeting to cilium";"Activation of SMO";"Class B/2 (Secretin family receptors)";"Hedgehog 'on' state";"Hedgehog 'off' state"
Mdes009168-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Mdes008272-RA	8	MetaCyc: PWY-1861;Reactome: R-HSA-6791055;Reactome: R-HSA-8950505;MetaCyc: PWY-5723;Reactome: R-HSA-71336;Reactome: R-HSA-6791462;Reactome: R-HSA-163754;KEGG: 00030+2.2.1.2	"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Rubisco shunt";"Pentose phosphate pathway";"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P";"Insulin effects increased synthesis of Xylulose-5-Phosphate";"Pentose phosphate pathway"
Mdes004370-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes017306-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes008624-RB	3	Reactome: R-HSA-110320;Reactome: R-HSA-5685942;Reactome: R-HSA-5656169	"Translesion Synthesis by POLH";"HDR through Homologous Recombination (HRR)";"Termination of translesion DNA synthesis"
Mdes002412-RA	7	Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-76071	"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter"
Mdes005401-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Mdes015391-RA	14	MetaCyc: PWY-6598;MetaCyc: PWY-7724;MetaCyc: PWY-7035;KEGG: 00062+2.3.1.199;MetaCyc: PWY-8041;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-7619;MetaCyc: PWY-7601;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-7725	"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Fatty acid elongation";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis V (8-detaturase, mammals)"
Mdes004211-RA	27	Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-159230;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-9610379;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408	"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP Dependant Mature mRNA";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"HCMV Late Events";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism"
Mdes003298-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes001878-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-72165;Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Mdes005662-RA	3	MetaCyc: PWY-1269;KEGG: 00540+2.7.7.38;Reactome: R-HSA-4085001	"CMP-3-deoxy-D-manno-octulosonate biosynthesis";"Lipopolysaccharide biosynthesis";"Sialic acid metabolism"
Mdes019211-RA	1	Reactome: R-HSA-71064	"Lysine catabolism"
Mdes019918-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes007832-RA	1	Reactome: R-HSA-2995383	"Initiation of Nuclear Envelope Reformation"
Mdes006570-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes018672-RA	4	Reactome: R-HSA-6782315;Reactome: R-HSA-6787450;KEGG: 00908+2.5.1.75;MetaCyc: PWY-2781	"tRNA modification in the nucleus and cytosol";"tRNA modification in the mitochondrion";"Zeatin biosynthesis";"Cis-zeatin biosynthesis"
Mdes018316-RA	3	MetaCyc: PWY-7546;Reactome: R-HSA-5358493;MetaCyc: PWY-6482	"Diphthamide biosynthesis II (eukaryotes)";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)"
Mdes007271-RA	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
Mdes006655-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway"
Mdes003451-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Mdes005826-RB	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes017699-RA	4	MetaCyc: PWY-3722;MetaCyc: PWY-7494;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163	"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV";"Glycine, serine and threonine metabolism";"Choline catabolism"
Mdes001879-RA	2	Reactome: R-HSA-8866654;Reactome: R-HSA-9033241	"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import"
Mdes008305-RA	7	Reactome: R-HSA-8964539;KEGG: 00250+3.5.1.2;Reactome: R-HSA-210500;KEGG: 00220+3.5.1.2;KEGG: 00471+3.5.1.2;Reactome: R-HSA-5628897;MetaCyc: PWY-5921	"Glutamate and glutamine metabolism";"Alanine, aspartate and glutamate metabolism";"Glutamate Neurotransmitter Release Cycle";"Arginine biosynthesis";"D-Glutamine and D-glutamate metabolism";"TP53 Regulates Metabolic Genes";"Glutaminyl-trnagln biosynthesis via transamidation"
Mdes010231-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes001908-RA	1	KEGG: 00970+6.1.1.20	"Aminoacyl-tRNA biosynthesis"
Mdes004293-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Mdes009187-RC	10	Reactome: R-HSA-9022538;Reactome: R-HSA-400206;Reactome: R-HSA-983231;Reactome: R-HSA-9022692;Reactome: R-HSA-427413;Reactome: R-HSA-3899300;Reactome: R-HSA-8936459;Reactome: R-HSA-9022699;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017	"Loss of MECP2 binding ability to 5mC-DNA";"Regulation of lipid metabolism by PPARalpha";"Factors involved in megakaryocyte development and platelet production";"Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression";"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"MECP2 regulates neuronal receptors and channels";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
Mdes005188-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes004609-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes013220-RA	10	Reactome: R-HSA-6804756;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-2151209;Reactome: R-HSA-9613354;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-163680;Reactome: R-HSA-5628897;Reactome: R-HSA-200425	"Regulation of TP53 Activity through Phosphorylation";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Lipophagy";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"AMPK inhibits chREBP transcriptional activation activity";"TP53 Regulates Metabolic Genes";"Carnitine metabolism"
Mdes009187-RB	10	Reactome: R-HSA-9022699;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-9022538;Reactome: R-HSA-9022692;Reactome: R-HSA-400206;Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-8936459;Reactome: R-HSA-3899300	"MECP2 regulates neuronal receptors and channels";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Loss of MECP2 binding ability to 5mC-DNA";"Regulation of MECP2 expression and activity";"Regulation of lipid metabolism by PPARalpha";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"SUMOylation of transcription cofactors"
Mdes001050-RA	83	Reactome: R-HSA-180336;Reactome: R-HSA-8853659;Reactome: R-HSA-1236382;Reactome: R-HSA-5654699;Reactome: R-HSA-112412;Reactome: R-HSA-5655291;Reactome: R-HSA-5637810;Reactome: R-HSA-9027284;Reactome: R-HSA-6807004;Reactome: R-HSA-8983432;Reactome: R-HSA-180292;Reactome: R-HSA-8875360;Reactome: R-HSA-1433557;Reactome: R-HSA-2871809;Reactome: R-HSA-210993;Reactome: R-HSA-8851805;Reactome: R-HSA-2179392;Reactome: R-HSA-8875555;Reactome: R-HSA-186763;Reactome: R-HSA-109704;Reactome: R-HSA-1433559;Reactome: R-HSA-983695;Reactome: R-HSA-512988;Reactome: R-HSA-5654706;Reactome: R-HSA-179812;Reactome: R-HSA-5654727;Reactome: R-HSA-5654704;Reactome: R-HSA-8875656;Reactome: R-HSA-912631;Reactome: R-HSA-9645135;Reactome: R-HSA-354194;Reactome: R-HSA-167044;Reactome: R-HSA-9034864;Reactome: R-HSA-9607240;Reactome: R-HSA-5654689;Reactome: R-HSA-2424491;Reactome: R-HSA-2871796;Reactome: R-HSA-5654733;Reactome: R-HSA-5654700;Reactome: R-HSA-8865999;Reactome: R-HSA-5654693;Reactome: R-HSA-8851907;Reactome: R-HSA-1963640;Reactome: R-HSA-74749;Reactome: R-HSA-8853338;Reactome: R-HSA-182971;Reactome: R-HSA-1257604;Reactome: R-HSA-5655302;Reactome: R-HSA-2428933;Reactome: R-HSA-1250196;Reactome: R-HSA-9028335;Reactome: R-HSA-5654719;Reactome: R-HSA-1963642;Reactome: R-HSA-2730905;Reactome: R-HSA-2219530;Reactome: R-HSA-375165;Reactome: R-HSA-5655253;Reactome: R-HSA-5663213;Reactome: R-HSA-5654695;Reactome: R-HSA-388841;Reactome: R-HSA-912526;Reactome: R-HSA-8853334;Reactome: R-HSA-5654720;Reactome: R-HSA-391160;Reactome: R-HSA-74751;Reactome: R-HSA-8856825;Reactome: R-HSA-1295596;Reactome: R-HSA-9634285;Reactome: R-HSA-9028731;Reactome: R-HSA-9026519;Reactome: R-HSA-389359;Reactome: R-HSA-8856828;Reactome: R-HSA-1250347;Reactome: R-HSA-5654726;Reactome: R-HSA-5673001;Reactome: R-HSA-9664565;Reactome: R-HSA-6811558;Reactome: R-HSA-5654712;Reactome: R-HSA-1839117;Reactome: R-HSA-5654688;Reactome: R-HSA-2029482;Reactome: R-HSA-5654732;Reactome: R-HSA-5654710	"SHC1 events in EGFR signaling";"RET signaling";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"SHC-mediated cascade:FGFR2";"SOS-mediated signalling";"Signaling by FGFR4 in disease";"Constitutive Signaling by EGFRvIII";"Erythropoietin activates RAS";"Negative regulation of MET activity";"Interleukin-15 signaling";"GAB1 signalosome";"InlB-mediated entry of Listeria monocytogenes into host cell";"Signaling by SCF-KIT";"FCERI mediated Ca+2 mobilization";"Tie2 Signaling";"MET activates RAS signaling";"EGFR Transactivation by Gastrin";"MET activates RAP1 and RAC1";"Downstream signal transduction";"PI3K Cascade";"Regulation of KIT signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"FRS-mediated FGFR3 signaling";"GRB2 events in EGFR signaling";"Negative regulation of FGFR2 signaling";"SHC-mediated cascade:FGFR3";"MET receptor recycling";"Regulation of signaling by CBL";"STAT5 Activation";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"Signalling to RAS";"Activated NTRK3 signals through RAS";"FLT3 Signaling";"PI-3K cascade:FGFR1";"DAP12 signaling";"FCERI mediated MAPK activation";"Negative regulation of FGFR4 signaling";"FRS-mediated FGFR2 signaling";"MET activates PTPN11";"FRS-mediated FGFR1 signaling";"MET activates PI3K/AKT signaling";"GRB2 events in ERBB2 signaling";"Signal attenuation";"Signaling by FGFR3 point mutants in cancer";"EGFR downregulation";"PIP3 activates AKT signaling";"Signaling by FGFR1 in disease";"SHC-related events triggered by IGF1R";"SHC1 events in ERBB2 signaling";"Activated NTRK2 signals through PI3K";"SHC-mediated cascade:FGFR4";"PI3K events in ERBB2 signaling";"Role of LAT2/NTAL/LAB on calcium mobilization";"Constitutive Signaling by Aberrant PI3K in Cancer";"NCAM signaling for neurite out-growth";"Signaling by FGFR2 in disease";"RHO GTPases Activate WASPs and WAVEs";"PI-3K cascade:FGFR2";"Costimulation by the CD28 family";"Interleukin receptor SHC signaling";"Signaling by FGFR3 fusions in cancer";"PI-3K cascade:FGFR4";"Signal regulatory protein family interactions";"Insulin receptor signalling cascade";"Cargo recognition for clathrin-mediated endocytosis";"Spry regulation of FGF signaling";"Constitutive Signaling by Overexpressed ERBB2";"Activated NTRK2 signals through FRS2 and FRS3";"Activated NTRK2 signals through RAS";"CD28 dependent Vav1 pathway";"Clathrin-mediated endocytosis";"SHC1 events in ERBB4 signaling";"Negative regulation of FGFR1 signaling";"RAF/MAP kinase cascade";"Signaling by ERBB2 KD Mutants";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"FRS-mediated FGFR4 signaling";"Signaling by cytosolic FGFR1 fusion mutants";"SHC-mediated cascade:FGFR1";"Regulation of actin dynamics for phagocytic cup formation";"Negative regulation of FGFR3 signaling";"PI-3K cascade:FGFR3"
Mdes010354-RA	5	MetaCyc: PWY-7210;Reactome: R-HSA-6798695;KEGG: 00240+3.6.1.6;KEGG: 00230+3.6.1.6;MetaCyc: PWY-7185	"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Neutrophil degranulation";"Pyrimidine metabolism";"Purine metabolism";"UTP and CTP dephosphorylation I"
Mdes010951-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes012054-RA	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
Mdes014181-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes003690-RC	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
Mdes003758-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes006921-RB	6	KEGG: 00270+4.1.1.50;MetaCyc: PWY-6834;KEGG: 00330+4.1.1.50;KEGG: 00970+6.3.5.7;Reactome: R-HSA-351202;Reactome: R-HSA-2142753	"Cysteine and methionine metabolism";"Spermidine biosynthesis III";"Arginine and proline metabolism";"Aminoacyl-tRNA biosynthesis";"Metabolism of polyamines";"Arachidonic acid metabolism"
Mdes017637-RA	13	Reactome: R-HSA-114508;Reactome: R-HSA-2029485;Reactome: R-HSA-139853;Reactome: R-HSA-422356;Reactome: R-HSA-2871809;Reactome: R-HSA-5607763;Reactome: R-HSA-5578775;Reactome: R-HSA-5218921;Reactome: R-HSA-1489509;Reactome: R-HSA-4086398;Reactome: R-HSA-983695;Reactome: R-HSA-381676;Reactome: R-HSA-112043	"Effects of PIP2 hydrolysis";"Role of phospholipids in phagocytosis";"Elevation of cytosolic Ca2+ levels";"Regulation of insulin secretion";"FCERI mediated Ca+2 mobilization";"CLEC7A (Dectin-1) induces NFAT activation";"Ion homeostasis";"VEGFR2 mediated cell proliferation";"DAG and IP3 signaling";"Ca2+ pathway";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"PLC beta mediated events"
Mdes002820-RC	5	Reactome: R-HSA-936964;Reactome: R-HSA-166166;Reactome: R-HSA-937041;Reactome: R-HSA-937072;Reactome: R-HSA-168164	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"MyD88-independent TLR4 cascade";"IKK complex recruitment mediated by RIP1";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Toll Like Receptor 3 (TLR3) Cascade"
Mdes017220-RA	4	KEGG: 00860+2.5.1.61;Reactome: R-HSA-189451;MetaCyc: PWY-5188;MetaCyc: PWY-5189	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Tetrapyrrole biosynthesis II (from glycine)"
Mdes008284-RB	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
Mdes000624-RA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Mdes000873-RA	16	Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes000411-RA	1	Reactome: R-HSA-163765	"ChREBP activates metabolic gene expression"
Mdes012968-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes018996-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes004593-RA	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
Mdes008610-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes003652-RA	13	MetaCyc: PWY-6728;Reactome: R-HSA-71403;MetaCyc: PWY-5690;MetaCyc: PWY-5538;KEGG: 00640+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-6969;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-7384;MetaCyc: PWY-5537;KEGG: 00020+6.2.1.5	"Methylaspartate cycle";"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Pyruvate fermentation to acetate VI";"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Pyruvate fermentation to acetate V";"Citrate cycle (TCA cycle)"
Mdes002451-RA	7	Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-8943724	"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Macroautophagy";"Regulation of PTEN gene transcription"
Mdes006529-RA	3	MetaCyc: PWY-2161B;Reactome: R-HSA-6798695;KEGG: 00790+3.4.19.9	"Glutamate removal from folates";"Neutrophil degranulation";"Folate biosynthesis"
Mdes019087-RA	5	Reactome: R-HSA-3359469;Reactome: R-HSA-156581;Reactome: R-HSA-3359467;Reactome: R-HSA-1614635;Reactome: R-HSA-196741	"Defective MTR causes methylmalonic aciduria and homocystinuria type cblG";"Methylation";"Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE";"Sulfur amino acid metabolism";"Cobalamin (Cbl, vitamin B12) transport and metabolism"
Mdes006364-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Mdes002302-RA	8	KEGG: 05165+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"Human papillomavirus infection";"Activation of RAC1";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
Mdes013815-RA	4	Reactome: R-HSA-975144;Reactome: R-HSA-9020702;Reactome: R-HSA-937039;MetaCyc: PWY-7511	"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Interleukin-1 signaling";"IRAK1 recruits IKK complex";"Protein ubiquitination"
Mdes011832-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Mdes006118-RB	3	MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167	"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol"
Mdes008626-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
Mdes004621-RA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
Mdes018851-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Mdes010026-RA	18	MetaCyc: PWY-6969;KEGG: 00270+1.1.1.37;MetaCyc: PWY-5392;MetaCyc: PWY-1622;Reactome: R-HSA-70263;MetaCyc: PWY-561;MetaCyc: PWY-5690;MetaCyc: PWY-5913;KEGG: 00620+1.1.1.37;MetaCyc: PWY-7383;KEGG: 00020+1.1.1.37;KEGG: 00720+1.1.1.37;KEGG: 00680+1.1.1.37;KEGG: 00630+1.1.1.37;MetaCyc: PWY-8086;KEGG: 00710+1.1.1.37;MetaCyc: PWY-6728;MetaCyc: PWY-7115	"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Cysteine and methionine metabolism";"Reductive TCA cycle II";"Formaldehyde assimilation I (serine pathway)";"Gluconeogenesis";"Superpathway of glyoxylate cycle and fatty acid degradation";"TCA cycle II (plants and fungi)";"Partial TCA cycle (obligate autotrophs)";"Pyruvate metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Methane metabolism";"Glyoxylate and dicarboxylate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Carbon fixation in photosynthetic organisms";"Methylaspartate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type"
Mdes005291-RA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Mdes007490-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
Mdes012195-RA	6	Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107	"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Glycerophospholipid metabolism"
Mdes008267-RC	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes003654-RA	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
Mdes000109-RA	9	Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-674695;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-73776	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Pre-transcription Events";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape"
Mdes000888-RA	5	Reactome: R-HSA-9646399;Reactome: R-HSA-5689877;Reactome: R-HSA-983168;Reactome: R-HSA-5205685;Reactome: R-HSA-977225	"Aggrephagy";"Josephin domain DUBs";"Antigen processing: Ubiquitination & Proteasome degradation";"Pink/Parkin Mediated Mitophagy";"Amyloid fiber formation"
Mdes018036-RA	4	KEGG: 00010+2.3.1.12;KEGG: 00020+2.3.1.12;KEGG: 00620+2.3.1.12;Reactome: R-HSA-389661	"Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation"
Mdes016430-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes003933-RA	42	Reactome: R-HSA-5250924;Reactome: R-HSA-912446;Reactome: R-HSA-212300;Reactome: R-HSA-1221632;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-606279;Reactome: R-HSA-9609690;Reactome: R-HSA-2559582;Reactome: R-HSA-427413;Reactome: R-HSA-977225;Reactome: R-HSA-4551638;Reactome: R-HSA-427359;Reactome: R-HSA-2559580;Reactome: R-HSA-110328;Reactome: R-HSA-5693565;Reactome: R-HSA-5617472;Reactome: R-HSA-110331;Reactome: R-HSA-2299718;Reactome: R-HSA-110330;Reactome: R-HSA-110329;Reactome: R-HSA-8939236;Reactome: R-HSA-5334118;Reactome: R-HSA-73728;Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-3214858;Reactome: R-HSA-3214842;Reactome: R-HSA-5693571;Reactome: R-HSA-8936459;Reactome: R-HSA-5578749;Reactome: R-HSA-3214841;Reactome: R-HSA-3214847;Reactome: R-HSA-427389;Reactome: R-HSA-201722;Reactome: R-HSA-9610379;Reactome: R-HSA-2559586;Reactome: R-HSA-73772;Reactome: R-HSA-3214815;Reactome: R-HSA-9616222;Reactome: R-HSA-5625886;Reactome: R-HSA-171306	"B-WICH complex positively regulates rRNA expression";"Meiotic recombination";"PRC2 methylates histones and DNA";"Meiotic synapsis";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Deposition of new CENPA-containing nucleosomes at the centromere";"HCMV Early Events";"Senescence-Associated Secretory Phenotype (SASP)";"NoRC negatively regulates rRNA expression";"Amyloid fiber formation";"SUMOylation of chromatin organization proteins";"SIRT1 negatively regulates rRNA expression";"Oxidative Stress Induced Senescence";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Cleavage of the damaged purine";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected purine";"Cleavage of the damaged pyrimidine";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"DNA methylation";"RNA Polymerase I Promoter Opening";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"RMTs methylate histone arginines";"HDMs demethylate histones";"Nonhomologous End-Joining (NHEJ)";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional regulation by small RNAs";"PKMTs methylate histone lysines";"HATs acetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Formation of the beta-catenin:TCF transactivating complex";"HCMV Late Events";"DNA Damage/Telomere Stress Induced Senescence";"RNA Polymerase I Promoter Escape";"HDACs deacetylate histones";"Transcriptional regulation of granulopoiesis";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Packaging Of Telomere Ends"
Mdes000344-RB	6	KEGG: 04070+3.1.3.64+3.1.3.95;KEGG: 00562+3.1.3.64+3.1.3.95;Reactome: R-HSA-1660499;MetaCyc: PWY-6580;MetaCyc: PWY-6368;MetaCyc: PWY-6367	"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol biosynthesis I (bacteria)";"3-phosphoinositide degradation";"D-myo-inositol-5-phosphate metabolism"
Mdes014172-RA	2	Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2	"Signaling by SCF-KIT";"T cell receptor signaling pathway"
Mdes007702-RA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
Mdes002200-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes009156-RA	3	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-390471	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis"
Mdes009223-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes005748-RA	5	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-204005;Reactome: R-HSA-6811434;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"COPII-mediated vesicle transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Intra-Golgi traffic"
Mdes005257-RA	16	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72706	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Mdes008267-RE	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes012724-RB	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Mdes019610-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes017803-RA	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
Mdes005629-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-71403	"Mitochondrial protein import";"Citric acid cycle (TCA cycle)"
Mdes003626-RA	1	Reactome: R-HSA-381038	"XBP1(S) activates chaperone genes"
Mdes003438-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes017644-RA	10	MetaCyc: PWY-1722;MetaCyc: PWY-2201;MetaCyc: PWY-7909;MetaCyc: PWY-6613;KEGG: 00670+1.5.1.5+3.5.4.9;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;Reactome: R-HSA-196757;MetaCyc: PWY-5497;MetaCyc: PWY-5030	"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate transformations I";"Formaldehyde oxidation VII (THF pathway)";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"One carbon pool by folate";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Metabolism of folate and pterines";"Purine nucleobases degradation II (anaerobic)";"L-histidine degradation III"
Mdes008221-RB	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes013880-RA	1	Reactome: R-HSA-419771	"Opsins"
Mdes006139-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Mdes015417-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes009187-RA	10	Reactome: R-HSA-400206;Reactome: R-HSA-983231;Reactome: R-HSA-9022692;Reactome: R-HSA-9022538;Reactome: R-HSA-3899300;Reactome: R-HSA-8936459;Reactome: R-HSA-427413;Reactome: R-HSA-9022702;Reactome: R-HSA-9022699;Reactome: R-HSA-9615017	"Regulation of lipid metabolism by PPARalpha";"Factors involved in megakaryocyte development and platelet production";"Regulation of MECP2 expression and activity";"Loss of MECP2 binding ability to 5mC-DNA";"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"NoRC negatively regulates rRNA expression";"MECP2 regulates transcription of neuronal ligands";"MECP2 regulates neuronal receptors and channels";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
Mdes012672-RA	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
Mdes002516-RA	11	MetaCyc: PWY-6383;MetaCyc: PWY-7560;MetaCyc: PWY-922;MetaCyc: PWY-5123;MetaCyc: PWY-7524;MetaCyc: PWY-6859;MetaCyc: PWY-6174;Reactome: R-HSA-191273;KEGG: 00900+5.3.3.2;MetaCyc: PWY-7102;MetaCyc: PWY-7391	"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Methylerythritol phosphate pathway II";"Mevalonate pathway I";"Trans, trans-farnesyl diphosphate biosynthesis";"Mevalonate pathway III (archaea)";"All-trans-farnesol biosynthesis";"Mevalonate pathway II (archaea)";"Cholesterol biosynthesis";"Terpenoid backbone biosynthesis";"Bisabolene biosynthesis (engineered)";"Isoprene biosynthesis II (engineered)"
Mdes008447-RA	3	Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-6807505	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"RNA polymerase II transcribes snRNA genes"
Mdes006172-RA	6	Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-68877	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase"
Mdes018849-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes000753-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes016203-RA	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
Mdes005158-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Mdes019328-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Mdes009256-RA	3	Reactome: R-HSA-1660661;Reactome: R-HSA-9609523;Reactome: R-HSA-6798695	"Sphingolipid de novo biosynthesis";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"Neutrophil degranulation"
Mdes016883-RA	2	KEGG: 00380+1.13.11.11;Reactome: R-HSA-71240	"Tryptophan metabolism";"Tryptophan catabolism"
Mdes005195-RA	6	Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-69052	"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA";"Switching of origins to a post-replicative state"
Mdes014967-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes005678-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
Mdes017468-RA	10	MetaCyc: PWY-5826;MetaCyc: PWY-7112;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-6842;MetaCyc: PWY-7559;MetaCyc: PWY-8001;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2	"Hypoglycin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Glutathione-mediated detoxification II";"Glutathione degradation (DUG pathway";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Glutathione metabolism";"Taurine and hypotaurine metabolism"
Mdes016919-RA	14	MetaCyc: PWY-5497;KEGG: 00460+2.1.2.1;KEGG: 00630+2.1.2.1;KEGG: 00670+2.1.2.1;MetaCyc: PWY-3661-1;KEGG: 00260+2.1.2.1;Reactome: R-HSA-196757;KEGG: 00680+2.1.2.1;MetaCyc: PWY-3841;MetaCyc: PWY-181;MetaCyc: PWY-2161;MetaCyc: PWY-1622;MetaCyc: PWY-3661;MetaCyc: PWY-2201	"Purine nucleobases degradation II (anaerobic)";"Cyanoamino acid metabolism";"Glyoxylate and dicarboxylate metabolism";"One carbon pool by folate";"Glycine betaine degradation II (mammalian)";"Glycine, serine and threonine metabolism";"Metabolism of folate and pterines";"Methane metabolism";"Folate transformations II (plants)";"Photorespiration ";"Folate polyglutamylation";"Formaldehyde assimilation I (serine pathway)";"Glycine betaine degradation I";"Folate transformations I"
Mdes008706-RA	12	Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-6804756;Reactome: R-HSA-167152;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-167246	"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript"
Mdes017758-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes014841-RA	1	Reactome: R-HSA-2465910	"MASTL Facilitates Mitotic Progression"
Mdes000652-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes007870-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes010103-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
Mdes008587-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-983231	"Mitochondrial calcium ion transport";"Factors involved in megakaryocyte development and platelet production"
Mdes005650-RA	1	Reactome: R-HSA-5250924	"B-WICH complex positively regulates rRNA expression"
Mdes002182-RA	1	Reactome: R-HSA-5617833	"Cilium Assembly"
Mdes010825-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes000134-RA	4	MetaCyc: PWY-7805;KEGG: 00190+3.6.1.1;Reactome: R-HSA-71737;MetaCyc: PWY-7807	"(aminomethyl)phosphonate degradation";"Oxidative phosphorylation";"Pyrophosphate hydrolysis";"Glyphosate degradation III"
Mdes005428-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes008422-RC	4	Reactome: R-HSA-2161541;KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221;Reactome: R-HSA-499943	"Abacavir metabolism";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates"
Mdes006773-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes007129-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes000284-RA	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
Mdes013591-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes006411-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Mdes012228-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Mdes000017-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
Mdes010469-RA	8	Reactome: R-HSA-8854518;Reactome: R-HSA-6804115;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-380259	"AURKA Activation by TPX2";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes"
Mdes002770-RA	18	MetaCyc: PWY-7179;MetaCyc: PWY-6608;MetaCyc: PWY-5695;MetaCyc: PWY-6644;MetaCyc: PWY-6611;MetaCyc: PWY-6609;KEGG: 00230+2.4.2.1;MetaCyc: PWY-6627;Reactome: R-HSA-73614;Reactome: R-HSA-73621;KEGG: 00983+2.4.2.3;KEGG: 00760+2.4.2.1;KEGG: 00240+2.4.2.3;MetaCyc: PWY-6620;MetaCyc: PWY-5532;KEGG: 00240+2.4.2.1;MetaCyc: PWY-4202;MetaCyc: PWY-7179-1	"Purine deoxyribonucleosides degradation I";"Guanosine nucleotides degradation III";"Inosine 5'-phosphate degradation";"Fluoroacetate and fluorothreonine biosynthesis";"Adenine and adenosine salvage V";"Adenine and adenosine salvage III";"Purine metabolism";"Salinosporamide A biosynthesis";"Pyrimidine salvage";"Pyrimidine catabolism";"Drug metabolism - other enzymes";"Nicotinate and nicotinamide metabolism";"Pyrimidine metabolism";"Guanine and guanosine salvage";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine metabolism";"Arsenate detoxification I (mammalian)";"Purine deoxyribonucleosides degradation II"
Mdes013620-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes004587-RB	7	Reactome: R-HSA-5673001;Reactome: R-HSA-373753;Reactome: R-HSA-375165;Reactome: R-HSA-6807878;Reactome: R-HSA-264870;Reactome: R-HSA-6798695;Reactome: R-HSA-445095	"RAF/MAP kinase cascade";"Nephrin family interactions";"NCAM signaling for neurite out-growth";"COPI-mediated anterograde transport";"Caspase-mediated cleavage of cytoskeletal proteins";"Neutrophil degranulation";"Interaction between L1 and Ankyrins"
Mdes001687-RA	13	Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-192823	"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation"
Mdes004654-RA	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
Mdes012885-RA	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
Mdes006130-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes018242-RA	5	Reactome: R-HSA-446210;MetaCyc: PWY-6749;MetaCyc: PWY-8013;KEGG: 00250+2.6.1.16;KEGG: 00520+2.6.1.16	"Synthesis of UDP-N-acetyl-glucosamine";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Amino sugar and nucleotide sugar metabolism"
Mdes012405-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes009622-RA	6	Reactome: R-HSA-3371599;MetaCyc: PWY-6987;Reactome: R-HSA-196780;KEGG: 00785+2.3.1.181;MetaCyc: PWY-7382;KEGG: 00780+6.3.4.15	"Defective HLCS causes multiple carboxylase deficiency";"Lipoate biosynthesis and incorporation III (Bacillus)";"Biotin transport and metabolism";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Biotin metabolism"
Mdes019152-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes016951-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes002029-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Mdes000667-RC	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
Mdes006945-RA	13	Reactome: R-HSA-167590;Reactome: R-HSA-8964038;Reactome: R-HSA-5099900;Reactome: R-HSA-177504;Reactome: R-HSA-437239;Reactome: R-HSA-8866427;Reactome: R-HSA-5140745;Reactome: R-HSA-8856825;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-8856828;Reactome: R-HSA-2132295;Reactome: R-HSA-182218	"Nef Mediated CD4 Down-regulation";"LDL clearance";"WNT5A-dependent internalization of FZD4";"Retrograde neurotrophin signalling";"Recycling pathway of L1";"VLDLR internalisation and degradation";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Cargo recognition for clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"Clathrin-mediated endocytosis";"MHC class II antigen presentation";"Nef Mediated CD8 Down-regulation"
Mdes005356-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes004662-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes010994-RA	5	MetaCyc: PWY-6853;Reactome: R-HSA-70688;KEGG: 00330+1.2.1.88;Reactome: R-HSA-389661;KEGG: 00250+1.2.1.88	"Ethylene biosynthesis II (microbes)";"Proline catabolism";"Arginine and proline metabolism";"Glyoxylate metabolism and glycine degradation";"Alanine, aspartate and glutamate metabolism"
Mdes006366-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes002416-RA	2	Reactome: R-HSA-111458;Reactome: R-HSA-9627069	"Formation of apoptosome";"Regulation of the apoptosome activity"
Mdes009651-RA	4	MetaCyc: PWY-7250;Reactome: R-HSA-947581;KEGG: 00730+2.8.1.7;Reactome: R-HSA-1362409	"[2Fe-2S] iron-sulfur cluster biosynthesis";"Molybdenum cofactor biosynthesis";"Thiamine metabolism";"Mitochondrial iron-sulfur cluster biogenesis"
Mdes009706-RA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
Mdes017390-RA	6	Reactome: R-HSA-176187;Reactome: R-HSA-5685938;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607	"Activation of ATR in response to replication stress";"HDR through Single Strand Annealing (SSA)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends"
Mdes011126-RA	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
Mdes008753-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Mdes006484-RA	2	Reactome: R-HSA-4570571;Reactome: R-HSA-446193	"Defective RFT1 causes RFT1-CDG (CDG-1n)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
Mdes000479-RA	1	Reactome: R-HSA-5689603	"UCH proteinases"
Mdes000554-RA	13	MetaCyc: PWY-7883;Reactome: R-HSA-1660662;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2022857;MetaCyc: PWY-7822;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00603+3.2.1.52	"Anhydromuropeptides recycling II";"Glycosphingolipid metabolism";"Various types of N-glycan biosynthesis";"Keratan sulfate degradation";"Chitin degradation III (Serratia)";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"CS/DS degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series"
Mdes007339-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes010313-RA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827	"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression"
Mdes006381-RA	5	Reactome: R-HSA-73762;Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-427413	"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression"
Mdes019949-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes008385-RA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
Mdes014943-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes009191-RA	13	Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-72689	"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Formation of a pool of free 40S subunits"
Mdes003602-RA	13	Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes014034-RA	13	MetaCyc: PWY-7210;KEGG: 00983+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7198;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7222;MetaCyc: PWY-7227;KEGG: 00480+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-7184;MetaCyc: PWY-7220;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7226	"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Adenosine deoxyribonucleotides de novo biosynthesis";"Glutathione metabolism";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I"
Mdes007778-RA	2	Reactome: R-HSA-1236974;Reactome: R-HSA-1799339	"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane"
Mdes011004-RA	6	Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72695	"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex"
Mdes017677-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Mdes001211-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis"
Mdes011059-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Mdes002206-RA	2	Reactome: R-HSA-5683371;Reactome: R-HSA-1369007	"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)";"Mitochondrial ABC transporters"
Mdes006309-RA	5	Reactome: R-HSA-171007;Reactome: R-HSA-168638;KEGG: 04150+2.7.11.24;Reactome: R-HSA-4420097;Reactome: R-HSA-376172	"p38MAPK events";"NOD1/2 Signaling Pathway";"mTOR signaling pathway";"VEGFA-VEGFR2 Pathway";"DSCAM interactions"
Mdes006620-RB	4	Reactome: R-HSA-5673001;Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-375165	"RAF/MAP kinase cascade";"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"NCAM signaling for neurite out-growth"
Mdes002981-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Mdes005135-RA	5	Reactome: R-HSA-5693571;Reactome: R-HSA-6798695;Reactome: R-HSA-164843;Reactome: R-HSA-3270619;Reactome: R-HSA-1834949	"Nonhomologous End-Joining (NHEJ)";"Neutrophil degranulation";"2-LTR circle formation";"IRF3-mediated induction of type I IFN";"Cytosolic sensors of pathogen-associated DNA"
Mdes004999-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes001998-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes012182-RA	3	Reactome: R-HSA-9603798;Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Class I peroxisomal membrane protein import";"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
Mdes009382-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes000471-RA	2	Reactome: R-HSA-5689896;Reactome: R-HSA-195253	"Ovarian tumor domain proteases";"Degradation of beta-catenin by the destruction complex"
Mdes018687-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Mdes016229-RA	5	Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-6798695;Reactome: R-HSA-3371497	"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Neutrophil degranulation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Mdes006994-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes010805-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes013877-RA	2	KEGG: 00480+3.4.11.2;Reactome: R-HSA-159236	"Glutathione metabolism";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Mdes010745-RA	1	Reactome: R-HSA-419771	"Opsins"
Mdes000817-RA	6	MetaCyc: PWY-7656;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-6733;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis"
Mdes012129-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes007128-RB	7	Reactome: R-HSA-381070;Reactome: R-HSA-381042;Reactome: R-HSA-3371453;Reactome: R-HSA-983170;Reactome: R-HSA-381183;Reactome: R-HSA-114608;Reactome: R-HSA-381033	"IRE1alpha activates chaperones";"PERK regulates gene expression";"Regulation of HSF1-mediated heat shock response";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"ATF6 (ATF6-alpha) activates chaperone genes";"Platelet degranulation";"ATF6 (ATF6-alpha) activates chaperones"
Mdes002002-RA	5	MetaCyc: PWY-7560;KEGG: 00730+2.2.1.7;KEGG: 00900+2.2.1.7;MetaCyc: PWY-6892;MetaCyc: PWY-6891	"Methylerythritol phosphate pathway II";"Thiamine metabolism";"Terpenoid backbone biosynthesis";"Thiazole biosynthesis I (facultative anaerobic bacteria)";"Thiazole biosynthesis II (aerobic bacteria)"
Mdes002993-RA	7	KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Relaxin signaling pathway"
Mdes016791-RC	4	KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282;Reactome: R-HSA-964975;MetaCyc: PWY-7204	"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Vitamins B6 activation to pyridoxal phosphate";"Pyridoxal 5'-phosphate salvage II (plants)"
Mdes001192-RA	8	Reactome: R-HSA-8856825;Reactome: R-HSA-5140745;Reactome: R-HSA-5099900;Reactome: R-HSA-432720;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-8856828;Reactome: R-HSA-3928665	"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"WNT5A-dependent internalization of FZD4";"Lysosome Vesicle Biogenesis";"Gap junction degradation";"Formation of annular gap junctions";"Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells"
Mdes000638-RA	12	MetaCyc: PWY-6969;MetaCyc: PWY-5913;MetaCyc: PWY-6549;KEGG: 00020+1.1.1.42;MetaCyc: PWY-7254;KEGG: 00720+1.1.1.42;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-7124;Reactome: R-HSA-428890;MetaCyc: PWY-7268;KEGG: 00480+1.1.1.42	"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)";"L-glutamine biosynthesis III";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"Carbon fixation pathways in prokaryotes";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"Ethylene biosynthesis V (engineered)";"Role of ABL in ROBO-SLIT signaling";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism"
Mdes008284-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
Mdes001337-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Mdes014146-RA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
Mdes004791-RA	4	KEGG: 00790+4.6.1.17;MetaCyc: PWY-6823;Reactome: R-HSA-947581;KEGG: 00790+4.1.99.22	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis"
Mdes010161-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Mdes010236-RA	13	KEGG: 05165+2.7.11.1;Reactome: R-HSA-6802952;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6802955;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6802946;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6802948;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9649948;Reactome: R-HSA-5674135	"Human papillomavirus infection";"Signaling by BRAF and RAF fusions";"mTOR signaling pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Signaling by moderate kinase activity BRAF mutants";"Relaxin signaling pathway";"Thermogenesis";"Signaling by high-kinase activity BRAF mutants";"Human cytomegalovirus infection";"Signaling downstream of RAS mutants";"MAP2K and MAPK activation"
Mdes017343-RA	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
Mdes008087-RB	20	KEGG: 00660+6.2.1.5;MetaCyc: PWY-6728;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5172;Reactome: R-HSA-163765;Reactome: R-HSA-6798695;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5913;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5538;Reactome: R-HSA-75105;MetaCyc: PWY-5690;Reactome: R-HSA-71403;KEGG: 00020+2.3.3.8;MetaCyc: PWY-5537;Reactome: R-HSA-1268020;MetaCyc: PWY-7384;MetaCyc: PWY-5392;KEGG: 00720+6.2.1.5;MetaCyc: PWY-6969	"C5-Branched dibasic acid metabolism";"Methylaspartate cycle";"Citrate cycle (TCA cycle)";"Acetyl-coa biosynthesis III (from citrate)";"ChREBP activates metabolic gene expression";"Neutrophil degranulation";"Carbon fixation pathways in prokaryotes";"Partial TCA cycle (obligate autotrophs)";"Propanoate metabolism";"Pyruvate fermentation to acetate VI";"Fatty acyl-CoA biosynthesis";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate V";"Mitochondrial protein import";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)"
Mdes008261-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Mdes000589-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes007117-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes018327-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Mdes010523-RA	2	Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
Mdes010296-RB	13	Reactome: R-HSA-5678895;Reactome: R-HSA-9646399;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346;Reactome: R-HSA-5689896;Reactome: R-HSA-8866654;Reactome: R-HSA-382556;Reactome: R-HSA-532668;Reactome: R-HSA-5689877;Reactome: R-HSA-3371511;Reactome: R-HSA-8876725;Reactome: R-HSA-6798695;Reactome: R-HSA-110320	"Defective CFTR causes cystic fibrosis";"Aggrephagy";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis";"Ovarian tumor domain proteases";"E3 ubiquitin ligases ubiquitinate target proteins";"ABC-family proteins mediated transport";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Josephin domain DUBs";"HSF1 activation";"Protein methylation";"Neutrophil degranulation";"Translesion Synthesis by POLH"
Mdes008738-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes012166-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-390450;Reactome: R-HSA-6814122	"Association of TriC/CCT with target proteins during biosynthesis";"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
Mdes010013-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation"
Mdes007697-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes013716-RA	1	Reactome: R-HSA-525793	"Myogenesis"
Mdes003684-RB	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
Mdes017737-RA	15	MetaCyc: PWY-7383;MetaCyc: PWY-2221;MetaCyc: PWY-6142;MetaCyc: PWY-6901;MetaCyc: PWY-6886;KEGG: 00620+2.7.1.40;MetaCyc: PWY-5723;MetaCyc: PWY-7003;MetaCyc: PWY-7218;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40;MetaCyc: PWY-1042;Reactome: R-HSA-70171;MetaCyc: PWY-8004;KEGG: 00010+2.7.1.40	"Anaerobic energy metabolism (invertebrates, cytosol)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Superpathway of glucose and xylose degradation";"1-butanol autotrophic biosynthesis (engineered)";"Pyruvate metabolism";"Rubisco shunt";"Glycerol degradation to butanol";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism";"Glycolysis IV (plant cytosol)";"Glycolysis";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis"
Mdes014218-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes013289-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Mdes001239-RB	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
Mdes019799-RA	2	MetaCyc: PWY-8073;KEGG: 00540+3.5.1.108	"Lipid IVA biosynthesis (P. putida)";"Lipopolysaccharide biosynthesis"
Mdes018720-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes002840-RA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
Mdes012410-RB	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes009734-RC	7	KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1	"Human cytomegalovirus infection";"mTOR signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway"
Mdes008267-RD	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes003354-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes016747-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Mdes006689-RA	5	Reactome: R-HSA-432722;Reactome: R-HSA-70688;MetaCyc: PWY-5737;KEGG: 00330+1.5.5.2;MetaCyc: PWY-6922	"Golgi Associated Vesicle Biogenesis";"Proline catabolism";"(5R)-carbapenem carboxylate biosynthesis";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis"
Mdes014956-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6798695	"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation"
Mdes006219-RA	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
Mdes004185-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Mdes005171-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes014597-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes000094-RA	7	Reactome: R-HSA-2122948;Reactome: R-HSA-2979096;Reactome: R-HSA-2660826;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232	"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
Mdes017411-RA	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
Mdes007176-RB	4	MetaCyc: PWY-7546;MetaCyc: PWY-6482;Reactome: R-HSA-5358493;Reactome: R-HSA-8849175	"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)";"Synthesis of diphthamide-EEF2";"Threonine catabolism"
Mdes018378-RA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
Mdes007418-RA	5	Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-350054;Reactome: R-HSA-3214815	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"HDACs deacetylate histones"
Mdes016382-RA	5	MetaCyc: PWY-7176;MetaCyc: PWY-7177;KEGG: 00240+6.3.4.2;MetaCyc: PWY-7185;Reactome: R-HSA-499943	"UTP and CTP de novo biosynthesis";"UTP and CTP dephosphorylation II";"Pyrimidine metabolism";"UTP and CTP dephosphorylation I";"Interconversion of nucleotide di- and triphosphates"
Mdes012919-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes009996-RA	11	MetaCyc: PWY-7939;KEGG: 00906+2.5.1.32+5.5.1.19;MetaCyc: PWY-6279;MetaCyc: PWY-7947;MetaCyc: PWY-7591;Reactome: R-HSA-2426168;MetaCyc: PWY-7938;MetaCyc: PWY-5943;Reactome: R-HSA-191273;Reactome: R-HSA-1989781;MetaCyc: PWY-5947	"Chlorobactene biosynthesis";"Carotenoid biosynthesis";"Myxol-2' fucoside biosynthesis";"Flexixanthin biosynthesis";"Okenone biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Isorenieratene biosynthesis I (actinobacteria)";"Beta-carotene biosynthesis";"Cholesterol biosynthesis";"PPARA activates gene expression";"Lutein biosynthesis"
Mdes005358-RA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Mdes001418-RB	6	Reactome: R-HSA-68949;Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-176187	"Orc1 removal from chromatin";"Switching of origins to a post-replicative state";"Unwinding of DNA";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress"
Mdes001780-RB	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
Mdes006782-RA	22	MetaCyc: PWY-7726;MetaCyc: PWY-7049;MetaCyc: PWY-6958;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7053;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-5353;MetaCyc: PWY-7592;MetaCyc: PWY-7728;KEGG: 00062+4.2.1.134;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-7602;MetaCyc: PWY-7727;MetaCyc: PWY-7601;Reactome: R-HSA-75876;MetaCyc: PWY-7606;MetaCyc: PWY-7035;MetaCyc: PWY-7724	"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Fatty acid elongation";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)"
Mdes005079-RB	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes011078-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Mdes012244-RA	11	Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-5620912;Reactome: R-HSA-3371497;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380320	"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Anchoring of the basal body to the plasma membrane";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Mdes011492-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes006870-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes016343-RA	4	MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49;KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268	"Entner-Doudoroff pathway I";"Pentose phosphate pathway";"Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
Mdes014676-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes016314-RA	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
Mdes013000-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes008413-RB	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes014947-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Mdes008781-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Mdes004574-RA	5	Reactome: R-HSA-8856828;Reactome: R-HSA-6807004;Reactome: R-HSA-182971;Reactome: R-HSA-8856825;Reactome: R-HSA-8875360	"Clathrin-mediated endocytosis";"Negative regulation of MET activity";"EGFR downregulation";"Cargo recognition for clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell"
Mdes009539-RA	7	Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-2565942	"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition"
Mdes000078-RA	2	Reactome: R-HSA-8866654;Reactome: R-HSA-9033241	"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import"
Mdes010247-RA	7	Reactome: R-HSA-1483226;MetaCyc: PWY-7625;MetaCyc: PWY-6352;KEGG: 00564+2.7.8.11;KEGG: 04070+2.7.8.11;MetaCyc: PWY-6351;KEGG: 00562+2.7.8.11	"Synthesis of PI";"Phosphatidylinositol biosynthesis II (eukaryotes)";"3-phosphoinositide biosynthesis";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism"
Mdes003212-RA	4	Reactome: R-HSA-3000170;Reactome: R-HSA-2129379;Reactome: R-HSA-216083;Reactome: R-HSA-3000178	"Syndecan interactions";"Molecules associated with elastic fibres";"Integrin cell surface interactions";"ECM proteoglycans"
Mdes005620-RA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
Mdes003803-RA	4	KEGG: 00480+2.5.1.16;KEGG: 00270+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00330+2.5.1.16	"Glutathione metabolism";"Cysteine and methionine metabolism";"Metabolism of polyamines";"Arginine and proline metabolism"
Mdes010243-RE	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Mdes007627-RA	18	MetaCyc: PWY-7115;KEGG: 00270+2.6.1.1;MetaCyc: PWY-6642;KEGG: 00710+2.6.1.1;KEGG: 00360+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00960+2.6.1.1;MetaCyc: PWY-7117;MetaCyc: PWY-7383;KEGG: 00400+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00950+2.6.1.1;MetaCyc: PWY-5913;KEGG: 00401+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00220+2.6.1.1;MetaCyc: PWY-6638	"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Cysteine and methionine metabolism";"(R)-cysteate degradation";"Carbon fixation in photosynthetic organisms";"Phenylalanine metabolism";"Coenzyme M biosynthesis II";"Tropane, piperidine and pyridine alkaloid biosynthesis";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine and proline metabolism";"Isoquinoline alkaloid biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Novobiocin biosynthesis";"Tyrosine metabolism";"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis";"Sulfolactate degradation III"
Mdes003861-RA	2	Reactome: R-HSA-6787450;Reactome: R-HSA-6782315	"tRNA modification in the mitochondrion";"tRNA modification in the nucleus and cytosol"
Mdes001288-RB	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes002453-RA	6	Reactome: R-HSA-6785470;Reactome: R-HSA-8868766;MetaCyc: PWY-6829;MetaCyc: PWY-7285;MetaCyc: PWY-7286;Reactome: R-HSA-6787450	"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion";"Trna methylation (yeast)";"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"tRNA modification in the mitochondrion"
Mdes004790-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Mdes006148-RB	2	Reactome: R-HSA-5218920;Reactome: R-HSA-418990	"VEGFR2 mediated vascular permeability";"Adherens junctions interactions"
Mdes017050-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes017246-RA	4	Reactome: R-HSA-9613829;Reactome: R-HSA-3899300;Reactome: R-HSA-9615710;Reactome: R-HSA-9646399	"Chaperone Mediated Autophagy";"SUMOylation of transcription cofactors";"Late endosomal microautophagy";"Aggrephagy"
Mdes001238-RB	3	Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-5689877	"DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"Josephin domain DUBs"
Mdes002879-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes016060-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes006397-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Mdes017363-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes008169-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Mdes014271-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Mdes005942-RA	13	Reactome: R-HSA-975163;Reactome: R-HSA-450302;Reactome: R-HSA-9020702;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-2871837;Reactome: R-HSA-445989;Reactome: R-HSA-9645460;Reactome: R-HSA-450321;Reactome: R-HSA-5607764;Reactome: R-HSA-937042;Reactome: R-HSA-168638;Reactome: R-HSA-9014325	"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"activated TAK1 mediates p38 MAPK activation";"Interleukin-1 signaling";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"FCERI mediated NF-kB activation";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Alpha-protein kinase 1 signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"CLEC7A (Dectin-1) signaling";"IRAK2 mediated activation of TAK1 complex";"NOD1/2 Signaling Pathway";"TICAM1,TRAF6-dependent induction of TAK1 complex"
Mdes001411-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Mdes019633-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes011937-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes006183-RA	5	MetaCyc: PWY-7082;MetaCyc: PWY-7279;MetaCyc: PWY-3781;KEGG: 00190+7.1.1.8;MetaCyc: PWY-6692	"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration I (cytochrome c)";"Oxidative phosphorylation";"Fe(II) oxidation"
Mdes003741-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Mdes003799-RA	3	MetaCyc: PWY-6823;KEGG: 00790+2.10.1.1;Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
Mdes010795-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes008806-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes010316-RA	9	Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-73779	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
Mdes008422-RB	4	KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541;MetaCyc: PWY-7221;Reactome: R-HSA-499943	"Purine metabolism";"Abacavir metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates"
Mdes014098-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Mdes002105-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
Mdes018480-RA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025	"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation"
Mdes011187-RA	8	MetaCyc: PWY-7979;Reactome: R-HSA-5083633;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;KEGG: 00515+2.4.1.109	"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Mannose type O-glycan biosynthesis"
Mdes000041-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Mdes003558-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Mdes017097-RA	4	Reactome: R-HSA-156581;MetaCyc: PWY-5041;KEGG: 00270+2.5.1.6;MetaCyc: PWY-5912	"Methylation";"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism";"2'-deoxymugineic acid phytosiderophore biosynthesis"
Mdes004587-RA	7	Reactome: R-HSA-264870;Reactome: R-HSA-375165;Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-6798695;Reactome: R-HSA-5673001;Reactome: R-HSA-373753	"Caspase-mediated cleavage of cytoskeletal proteins";"NCAM signaling for neurite out-growth";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"Neutrophil degranulation";"RAF/MAP kinase cascade";"Nephrin family interactions"
Mdes002802-RA	3	Reactome: R-HSA-975577;Reactome: R-HSA-913709;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"O-linked glycosylation of mucins";"Keratan sulfate biosynthesis"
Mdes016562-RA	21	MetaCyc: PWY-7315;MetaCyc: PWY-6974;MetaCyc: PWY-6973;MetaCyc: PWY-6953;MetaCyc: PWY-6808;MetaCyc: PWY-7104;MetaCyc: PWY-7316;MetaCyc: PWY-7413;KEGG: 00521+4.2.1.46;MetaCyc: PWY-7312;MetaCyc: PWY-7318;MetaCyc: PWY-7814;KEGG: 00525+4.2.1.46;MetaCyc: PWY-7301;MetaCyc: PWY-7688;MetaCyc: PWY-7657;MetaCyc: PWY-6942;MetaCyc: PWY-7414;MetaCyc: PWY-6976;KEGG: 00523+4.2.1.46;MetaCyc: PWY-7440	"Dtdp-n-acetylthomosamine biosynthesis";"Dtdp-l-olivose biosynthesis";"Dtdp-d-olivose, dTDP-D-oliose and dTDP-D-mycarose biosynthesis";"Dtdp-3-acetamido-alpha-d-fucose biosynthesis";"Dtdp-d-forosamine biosynthesis";"Dtdp-l-megosamine biosynthesis";"Dtdp-n-acetylviosamine biosynthesis";"Dtdp-6-deoxy-alpha-d-allose biosynthesis";"Streptomycin biosynthesis";"Dtdp-d-beta-fucofuranose biosynthesis";"Dtdp-3-acetamido-3,6-dideoxy-alpha-d-glucose biosynthesis";"Dtdp-l-daunosamine biosynthesis";"Acarbose and validamycin biosynthesis";"Dtdp-4-o-demethyl-beta-l-noviose biosynthesis";"Dtdp-d-ravidosamine and dTDP-4-acetyl-D-ravidosamine biosynthesis";"Dtdp-beta-l-digitoxose biosynthesis";"Dtdp-d-desosamine biosynthesis";"Dtdp-alpha-d-mycaminose biosynthesis";"Dtdp-l-mycarose biosynthesis";"Polyketide sugar unit biosynthesis";"Dtdp-beta-l-4-epi-vancosamine biosynthesis"
Mdes000683-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes004717-RB	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes015163-RA	52	Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-427413;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-76071;Reactome: R-HSA-167238;Reactome: R-HSA-72163;Reactome: R-HSA-9018519;Reactome: R-HSA-77075;Reactome: R-HSA-5250924;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-73780;Reactome: R-HSA-167162;Reactome: R-HSA-8851708;Reactome: R-HSA-75955;Reactome: R-HSA-1834949;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-72203;Reactome: R-HSA-6807505;Reactome: R-HSA-203927;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-5617472;Reactome: R-HSA-76066;Reactome: R-HSA-167290;Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-5578749;Reactome: R-HSA-73762;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-76042;Reactome: R-HSA-72165;Reactome: R-HSA-73779;Reactome: R-HSA-5601884;Reactome: R-HSA-6796648;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6803529;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-674695;Reactome: R-HSA-73980	"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"NoRC negatively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Major Pathway";"Estrogen-dependent gene expression";"RNA Pol II CTD phosphorylation and interaction with CE";"B-WICH complex positively regulates rRNA expression";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"RNA Polymerase III Chain Elongation";"RNA Polymerase II HIV Promoter Escape";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Elongation";"Cytosolic sensors of pathogen-associated DNA";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"Processing of Capped Intron-Containing Pre-mRNA";"RNA polymerase II transcribes snRNA genes";"MicroRNA (miRNA) biogenesis";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Viral Messenger RNA Synthesis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Pausing and recovery of HIV elongation";"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Transcriptional regulation by small RNAs";"RNA Polymerase I Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"PIWI-interacting RNA (piRNA) biogenesis";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"FGFR2 alternative splicing";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"HIV Transcription Initiation";"Dual incision in TC-NER";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase III Transcription Termination"
Mdes005376-RA	2	Reactome: R-HSA-1221632;Reactome: R-HSA-5601884	"Meiotic synapsis";"PIWI-interacting RNA (piRNA) biogenesis"
Mdes010689-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Mdes005288-RA	4	Reactome: R-HSA-3371568;Reactome: R-HSA-8939211;Reactome: R-HSA-9018519;Reactome: R-HSA-3371497	"Attenuation phase";"ESR-mediated signaling";"Estrogen-dependent gene expression";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Mdes011495-RA	7	Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.17;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.15;Reactome: R-HSA-6782315;MetaCyc: PWY-5188;KEGG: 00860+6.1.1.17	"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"tRNA modification in the nucleus and cytosol";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism"
Mdes005483-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes004948-RA	19	Reactome: R-HSA-8856828;Reactome: R-HSA-8957275;Reactome: R-HSA-8963901;Reactome: R-HSA-975634;Reactome: R-HSA-8964038;Reactome: R-HSA-202733;Reactome: R-HSA-8964046;Reactome: R-HSA-8856825;Reactome: R-HSA-3000471;Reactome: R-HSA-8963888;Reactome: R-HSA-3000497;Reactome: R-HSA-8964026;Reactome: R-HSA-3000480;Reactome: R-HSA-432142;Reactome: R-HSA-5686938;Reactome: R-HSA-3000484;Reactome: R-HSA-8866423;Reactome: R-HSA-381426;Reactome: R-HSA-8964041	"Clathrin-mediated endocytosis";"Post-translational protein phosphorylation";"Chylomicron remodeling";"Retinoid metabolism and transport";"LDL clearance";"Cell surface interactions at the vascular wall";"VLDL clearance";"Cargo recognition for clathrin-mediated endocytosis";"Scavenging by Class B Receptors";"Chylomicron assembly";"Scavenging by Class H Receptors";"Chylomicron clearance";"Scavenging by Class A Receptors";"Platelet sensitization by LDL";"Regulation of TLR by endogenous ligand";"Scavenging by Class F Receptors";"VLDL assembly";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"LDL remodeling"
Mdes000308-RA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
Mdes015900-RA	42	Reactome: R-HSA-2299718;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-110330;Reactome: R-HSA-5693565;Reactome: R-HSA-110328;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-4551638;Reactome: R-HSA-977225;Reactome: R-HSA-427413;Reactome: R-HSA-427359;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-606279;Reactome: R-HSA-1221632;Reactome: R-HSA-912446;Reactome: R-HSA-5250924;Reactome: R-HSA-212300;Reactome: R-HSA-2559582;Reactome: R-HSA-9609690;Reactome: R-HSA-2559586;Reactome: R-HSA-73772;Reactome: R-HSA-3214815;Reactome: R-HSA-9610379;Reactome: R-HSA-5625886;Reactome: R-HSA-171306;Reactome: R-HSA-9616222;Reactome: R-HSA-3214847;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-427389;Reactome: R-HSA-8936459;Reactome: R-HSA-5578749;Reactome: R-HSA-5693607;Reactome: R-HSA-5334118;Reactome: R-HSA-73728;Reactome: R-HSA-8939236;Reactome: R-HSA-5693571;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-3214858	"Condensation of Prophase Chromosomes";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"SUMOylation of chromatin organization proteins";"Amyloid fiber formation";"NoRC negatively regulates rRNA expression";"SIRT1 negatively regulates rRNA expression";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Deposition of new CENPA-containing nucleosomes at the centromere";"Meiotic synapsis";"Meiotic recombination";"B-WICH complex positively regulates rRNA expression";"PRC2 methylates histones and DNA";"Senescence-Associated Secretory Phenotype (SASP)";"HCMV Early Events";"DNA Damage/Telomere Stress Induced Senescence";"RNA Polymerase I Promoter Escape";"HDACs deacetylate histones";"HCMV Late Events";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Packaging Of Telomere Ends";"Transcriptional regulation of granulopoiesis";"HATs acetylate histones";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional regulation by small RNAs";"Processing of DNA double-strand break ends";"DNA methylation";"RNA Polymerase I Promoter Opening";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Nonhomologous End-Joining (NHEJ)";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"RMTs methylate histone arginines"
Mdes002893-RA	10	Reactome: R-HSA-975634;MetaCyc: PWY-7849;Reactome: R-HSA-2453902;Reactome: R-HSA-977225;Reactome: R-HSA-6798695;MetaCyc: PWY-5691;MetaCyc: PWY-7394;KEGG: 00230+3.5.2.17;Reactome: R-HSA-3000171;Reactome: R-HSA-2453864	"Retinoid metabolism and transport";"Urate conversion to allantoin III";"The canonical retinoid cycle in rods (twilight vision)";"Amyloid fiber formation";"Neutrophil degranulation";"Urate conversion to allantoin I";"Urate conversion to allantoin II";"Purine metabolism";"Non-integrin membrane-ECM interactions";"Retinoid cycle disease events"
Mdes014494-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes015014-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes005326-RB	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes010218-RC	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
Mdes006443-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Mdes018298-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes013070-RC	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Mdes011342-RA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
Mdes008718-RA	10	MetaCyc: PWY-7524;KEGG: 00280+2.3.3.10;MetaCyc: PWY-922;KEGG: 00900+2.3.3.10;KEGG: 00650+2.3.3.10;MetaCyc: PWY-7391;MetaCyc: PWY-7571;Reactome: R-HSA-1989781;MetaCyc: PWY-6174;KEGG: 00072+2.3.3.10	"Mevalonate pathway III (archaea)";"Valine, leucine and isoleucine degradation";"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Butanoate metabolism";"Isoprene biosynthesis II (engineered)";"Ferrichrome A biosynthesis";"PPARA activates gene expression";"Mevalonate pathway II (archaea)";"Synthesis and degradation of ketone bodies"
Mdes002688-RA	43	Reactome: R-HSA-9648025;Reactome: R-HSA-1221632;KEGG: 05165+2.7.11.1;Reactome: R-HSA-68877;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-190861;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6783310;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-190840;Reactome: R-HSA-380320;Reactome: R-HSA-8955332;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-9609736;Reactome: R-HSA-389960;Reactome: R-HSA-5693607;KEGG: 04150+2.7.11.1;Reactome: R-HSA-389977;Reactome: R-HSA-176187;Reactome: R-HSA-6796648;Reactome: R-HSA-69473;Reactome: R-HSA-9646399;Reactome: R-HSA-3371453;Reactome: R-HSA-8852276;Reactome: R-HSA-6811434;Reactome: R-HSA-5685938;Reactome: R-HSA-9619483;Reactome: R-HSA-5693616;Reactome: R-HSA-5626467;Reactome: R-HSA-5617833;Reactome: R-HSA-983189;Reactome: R-HSA-2467813;Reactome: R-HSA-2132295;KEGG: 04714+2.7.11.1;Reactome: R-HSA-437239	"EML4 and NUDC in mitotic spindle formation";"Meiotic synapsis";"Human papillomavirus infection";"Mitotic Prometaphase";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Gap junction assembly";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"Fanconi Anemia Pathway";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Carboxyterminal post-translational modifications of tubulin";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"Assembly and cell surface presentation of NMDA receptors";"Formation of tubulin folding intermediates by CCT/TriC";"Processing of DNA double-strand break ends";"mTOR signaling pathway";"Post-chaperonin tubulin folding pathway";"Activation of ATR in response to replication stress";"TP53 Regulates Transcription of DNA Repair Genes";"G2/M DNA damage checkpoint";"Aggrephagy";"Regulation of HSF1-mediated heat shock response";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-dependent Golgi-to-ER retrograde traffic";"HDR through Single Strand Annealing (SSA)";"Activation of AMPK downstream of NMDARs";"Presynaptic phase of homologous DNA pairing and strand exchange";"RHO GTPases activate IQGAPs";"Cilium Assembly";"Kinesins";"Separation of Sister Chromatids";"MHC class II antigen presentation";"Thermogenesis";"Recycling pathway of L1"
Mdes011234-RB	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes001573-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes005817-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes013072-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Mdes002212-RB	5	MetaCyc: PWY-5981;MetaCyc: PWY-5667;KEGG: 00564+2.7.7.41;MetaCyc: PWY-7817;KEGG: 04070+2.7.7.41	"CDP-diacylglycerol biosynthesis III";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system"
Mdes000063-RB	4	KEGG: 00473+5.1.1.1;MetaCyc: PWY-8040;MetaCyc: PWY-7383;MetaCyc: PWY-8072	"D-Alanine metabolism";"Ansatrienin biosynthesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Alanine racemization"
Mdes011464-RB	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
Mdes017715-RA	5	MetaCyc: PWY-7185;Reactome: R-HSA-499943;MetaCyc: PWY-7177;MetaCyc: PWY-7176;KEGG: 00240+6.3.4.2	"UTP and CTP dephosphorylation I";"Interconversion of nucleotide di- and triphosphates";"UTP and CTP dephosphorylation II";"UTP and CTP de novo biosynthesis";"Pyrimidine metabolism"
Mdes018441-RA	4	Reactome: R-HSA-389661;KEGG: 00620+2.3.1.12;KEGG: 00020+2.3.1.12;KEGG: 00010+2.3.1.12	"Glyoxylate metabolism and glycine degradation";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Glycolysis / Gluconeogenesis"
Mdes010987-RA	3	Reactome: R-HSA-4608870;Reactome: R-HSA-373080;Reactome: R-HSA-4086400	"Asymmetric localization of PCP proteins";"Class B/2 (Secretin family receptors)";"PCP/CE pathway"
Mdes005713-RB	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes009114-RA	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
Mdes004456-RB	8	Reactome: R-HSA-111458;Reactome: R-HSA-6803207;Reactome: R-HSA-111459;Reactome: R-HSA-111464;Reactome: R-HSA-6798695;Reactome: R-HSA-111463;Reactome: R-HSA-9627069;Reactome: R-HSA-8953750	"Formation of apoptosome";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Activation of caspases through apoptosome-mediated cleavage";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Neutrophil degranulation";"SMAC (DIABLO) binds to IAPs";"Regulation of the apoptosome activity";"Transcriptional Regulation by E2F6"
Mdes012270-RA	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
Mdes011343-RA	6	MetaCyc: PWY-5723;MetaCyc: PWY-1861;KEGG: 00030+5.1.3.1;KEGG: 00040+5.1.3.1;KEGG: 00710+5.1.3.1;Reactome: R-HSA-71336	"Rubisco shunt";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"Pentose and glucuronate interconversions";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway"
Mdes003987-RA	6	Reactome: R-HSA-450604;Reactome: R-HSA-6791226;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"KSRP (KHSRP) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes000376-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8949664	"Mitochondrial protein import";"Processing of SMDT1"
Mdes010832-RA	6	Reactome: R-HSA-5358606;Reactome: R-HSA-5632968;Reactome: R-HSA-5632928;Reactome: R-HSA-5632927;Reactome: R-HSA-5358565;Reactome: R-HSA-6796648	"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With MSH6";"Defective Mismatch Repair Associated With MSH2";"Defective Mismatch Repair Associated With MSH3";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"TP53 Regulates Transcription of DNA Repair Genes"
Mdes008823-RA	6	Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72695	"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex"
Mdes001128-RB	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes005659-RA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
Mdes008382-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Mdes007860-RA	7	MetaCyc: PWY-6277;KEGG: 00250+2.4.2.14;MetaCyc: PWY-7282;MetaCyc: PWY-6122;MetaCyc: PWY-6121;KEGG: 00230+2.4.2.14;Reactome: R-HSA-73817	"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Alanine, aspartate and glutamate metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis"
Mdes005317-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes000894-RA	4	Reactome: R-HSA-156581;Reactome: R-HSA-6782315;Reactome: R-HSA-6790901;Reactome: R-HSA-72764	"Methylation";"tRNA modification in the nucleus and cytosol";"rRNA modification in the nucleus and cytosol";"Eukaryotic Translation Termination"
Mdes007408-RA	15	Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5693565;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5693616;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693548;Reactome: R-HSA-5685938;Reactome: R-HSA-2559586;Reactome: R-HSA-5693568;Reactome: R-HSA-5685939	"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Processing of DNA double-strand break ends";"Meiotic recombination";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Sensing of DNA Double Strand Breaks";"HDR through Single Strand Annealing (SSA)";"DNA Damage/Telomere Stress Induced Senescence";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through MMEJ (alt-NHEJ)"
Mdes003161-RA	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Mdes003066-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes012893-RA	57	Reactome: R-HSA-5610783;Reactome: R-HSA-69481;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-2467813;Reactome: R-HSA-187577;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-450408;Reactome: R-HSA-5687128;Reactome: R-HSA-6798695;Reactome: R-HSA-8852276;Reactome: R-HSA-8941858;Reactome: R-HSA-5607764;Reactome: R-HSA-5689880;Reactome: R-HSA-5632684;Reactome: R-HSA-174154;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-1236978;Reactome: R-HSA-68827;Reactome: R-HSA-5658442;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-5668541;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-4641258;Reactome: R-HSA-8939902;Reactome: R-HSA-5362768;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-9010553;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702	"Degradation of GLI2 by the proteasome";"G2/M Checkpoints";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Separation of Sister Chromatids";"SCF(Skp2)-mediated degradation of p27/p21";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"MAPK6/MAPK4 signaling";"Neutrophil degranulation";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of RUNX3 expression and activity";"CLEC7A (Dectin-1) signaling";"Ub-specific processing proteases";"Hedgehog 'on' state";"APC/C:Cdc20 mediated degradation of Securin";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Cross-presentation of soluble exogenous antigens (endosomes)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of RAS by GAPs";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Neddylation";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"TNFR2 non-canonical NF-kB pathway";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of DVL";"Regulation of RUNX2 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of expression of SLITs and ROBOs";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling"
Mdes005664-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes009234-RA	2	Reactome: R-HSA-194840;Reactome: R-HSA-9639288	"Rho GTPase cycle";"Amino acids regulate mTORC1"
Mdes014047-RA	4	Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-8866654	"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins"
Mdes003618-RA	4	KEGG: 00230+4.6.1.1;Reactome: R-HSA-9603798;Reactome: R-HSA-196819;Reactome: R-HSA-1369062	"Purine metabolism";"Class I peroxisomal membrane protein import";"Vitamin B1 (thiamin) metabolism";"ABC transporters in lipid homeostasis"
Mdes011210-RB	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Mdes000307-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Mdes008005-RA	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
Mdes019017-RA	4	MetaCyc: PWY-7790;KEGG: 00240+3.5.2.3;MetaCyc: PWY-5686;MetaCyc: PWY-7791	"UMP biosynthesis II";"Pyrimidine metabolism";"UMP biosynthesis I";"UMP biosynthesis III"
Mdes012869-RA	5	Reactome: R-HSA-196807;MetaCyc: PWY-7221;Reactome: R-HSA-73621;Reactome: R-HSA-74259;KEGG: 00230+2.7.4.8	"Nicotinate metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine catabolism";"Purine catabolism";"Purine metabolism"
Mdes006304-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes005424-RA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
Mdes010080-RA	13	Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226	"Eukaryotic Translation Termination";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes006164-RA	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
Mdes019771-RA	15	Reactome: R-HSA-912446;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607;Reactome: R-HSA-5693565;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693571;Reactome: R-HSA-5685939;Reactome: R-HSA-5693568;Reactome: R-HSA-2559586;Reactome: R-HSA-5693548;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942	"Meiotic recombination";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Nonhomologous End-Joining (NHEJ)";"HDR through MMEJ (alt-NHEJ)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"DNA Damage/Telomere Stress Induced Senescence";"Sensing of DNA Double Strand Breaks";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)"
Mdes016482-RA	2	Reactome: R-HSA-171319;Reactome: R-HSA-3214847	"Telomere Extension By Telomerase";"HATs acetylate histones"
Mdes007486-RA	5	Reactome: R-HSA-201722;Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of the beta-catenin:TCF transactivating complex";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
Mdes017325-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes012196-RB	6	Reactome: R-HSA-114508;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107	"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Glycerophospholipid metabolism"
Mdes012292-RA	8	Reactome: R-HSA-68962;Reactome: R-HSA-68616;Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68949;Reactome: R-HSA-68689	"Activation of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Orc1 removal from chromatin";"CDC6 association with the ORC:origin complex"
Mdes010329-RA	14	Reactome: R-HSA-5656121;Reactome: R-HSA-6782135;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-110320;Reactome: R-HSA-69091;Reactome: R-HSA-110312;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-6782210;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400	"Translesion synthesis by POLI";"Dual incision in TC-NER";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"Translesion Synthesis by POLH";"Polymerase switching";"Translesion synthesis by REV1";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by POLK";"Dual Incision in GG-NER"
Mdes000936-RA	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
Mdes013368-RA	13	KEGG: 00760+3.6.1.9;KEGG: 00770+3.6.1.9;KEGG: 00500+3.6.1.9;MetaCyc: PWY-7206;KEGG: 00740+3.6.1.9;MetaCyc: PWY-7187;MetaCyc: PWY-6545;Reactome: R-HSA-74259;KEGG: 00240+3.6.1.9;KEGG: 00230+3.6.1.9;KEGG: 00230+3.6.1.66;MetaCyc: PWY-7184;MetaCyc: PWY-7821	"Nicotinate and nicotinamide metabolism";"Pantothenate and CoA biosynthesis";"Starch and sucrose metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation";"Riboflavin metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine catabolism";"Pyrimidine metabolism";"Purine metabolism";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Tunicamycin biosynthesis"
Mdes010940-RA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
Mdes000500-RA	4	Reactome: R-HSA-4717374;Reactome: R-HSA-4719377;Reactome: R-HSA-4719360;Reactome: R-HSA-162699	"Defective DPM1 causes DPM1-CDG (CDG-1e)";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Synthesis of dolichyl-phosphate mannose"
Mdes006972-RA	6	Reactome: R-HSA-204005;Reactome: R-HSA-6811434;Reactome: R-HSA-6811438;Reactome: R-HSA-416993;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"COPII-mediated vesicle transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Intra-Golgi traffic";"Trafficking of GluR2-containing AMPA receptors";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
Mdes002600-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Mdes001381-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes002733-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-5205685	"Mitochondrial protein import";"Pink/Parkin Mediated Mitophagy"
Mdes015224-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Mdes007597-RA	16	Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72695;Reactome: R-HSA-2408557;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-72764	"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Selenocysteine synthesis";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Eukaryotic Translation Termination"
Mdes007088-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes002459-RA	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Mdes002097-RA	4	MetaCyc: PWY-5905;Reactome: R-HSA-77289;Reactome: R-HSA-204626;Reactome: R-HSA-72163	"Hypusine biosynthesis";"Mitochondrial Fatty Acid Beta-Oxidation";"Hypusine synthesis from eIF5A-lysine";"mRNA Splicing - Major Pathway"
Mdes002023-RA	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
Mdes008906-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes016605-RA	3	Reactome: R-HSA-2408522;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.4	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes011665-RA	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
Mdes002228-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Mdes010587-RC	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
Mdes018543-RA	3	KEGG: 00040+5.3.1.17;KEGG: 00562+5.3.1.30;MetaCyc: PWY-6507	"Pentose and glucuronate interconversions";"Inositol phosphate metabolism";"4-deoxy-L-threo-hex-4-enopyranuronate degradation"
Mdes018358-RA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-8957275;Reactome: R-HSA-381038;Reactome: R-HSA-381426;Reactome: R-HSA-192823	"Neutrophil degranulation";"Post-translational protein phosphorylation";"XBP1(S) activates chaperone genes";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Viral mRNA Translation"
Mdes013285-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes011430-RB	8	Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;MetaCyc: PWY-7980;Reactome: R-HSA-917977;Reactome: R-HSA-77387;KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;Reactome: R-HSA-983712	"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"ATP biosynthesis";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Photosynthesis";"Oxidative phosphorylation";"Ion channel transport"
Mdes009369-RA	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
Mdes012252-RA	4	Reactome: R-HSA-3304356;Reactome: R-HSA-2173789;Reactome: R-HSA-3656532;Reactome: R-HSA-2173788	"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGF-beta receptor signaling activates SMADs";"TGFBR1 KD Mutants in Cancer";"Downregulation of TGF-beta receptor signaling"
Mdes005111-RA	5	Reactome: R-HSA-1482883;KEGG: 00561+2.3.1.20;Reactome: R-HSA-75109;KEGG: 00073+2.3.1.20;Reactome: R-HSA-6798695	"Acyl chain remodeling of DAG and TAG";"Glycerolipid metabolism";"Triglyceride biosynthesis";"Cutin, suberine and wax biosynthesis";"Neutrophil degranulation"
Mdes008288-RA	3	Reactome: R-HSA-70268;KEGG: 00620+4.4.1.5;MetaCyc: PWY-5386	"Pyruvate metabolism";"Pyruvate metabolism";"Methylglyoxal degradation I"
Mdes001333-RA	2	Reactome: R-HSA-5689880;Reactome: R-HSA-1632852	"Ub-specific processing proteases";"Macroautophagy"
Mdes012956-RA	4	Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664	"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation"
Mdes005156-RA	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
Mdes005521-RA	3	Reactome: R-HSA-191859;Reactome: R-HSA-3214858;Reactome: R-HSA-6804760	"snRNP Assembly";"RMTs methylate histone arginines";"Regulation of TP53 Activity through Methylation"
Mdes009306-RA	14	Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-1632852;Reactome: R-HSA-5620924;Reactome: R-HSA-5663220	"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"Mitotic Prometaphase";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Macroautophagy";"Intraflagellar transport";"RHO GTPases Activate Formins"
Mdes011458-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Mdes001497-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Mdes004834-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Mdes016382-RC	5	Reactome: R-HSA-499943;MetaCyc: PWY-7185;MetaCyc: PWY-7177;MetaCyc: PWY-7176;KEGG: 00240+6.3.4.2	"Interconversion of nucleotide di- and triphosphates";"UTP and CTP dephosphorylation I";"UTP and CTP dephosphorylation II";"UTP and CTP de novo biosynthesis";"Pyrimidine metabolism"
Mdes010037-RA	1	Reactome: R-HSA-2142789	"Ubiquinol biosynthesis"
Mdes006627-RA	22	Reactome: R-HSA-5358752;Reactome: R-HSA-5339716;Reactome: R-HSA-195253;Reactome: R-HSA-141444;Reactome: R-HSA-5467340;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-4641262;Reactome: R-HSA-389513;Reactome: R-HSA-5358749;Reactome: R-HSA-5663220;Reactome: R-HSA-5675221;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-5358751;Reactome: R-HSA-5673000;Reactome: R-HSA-5467348;Reactome: R-HSA-5358747;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-432142;Reactome: R-HSA-6811558	"T41 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Degradation of beta-catenin by the destruction complex";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"AXIN missense mutants destabilize the destruction complex";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"CTLA4 inhibitory signaling";"S37 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"Negative regulation of MAPK pathway";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"S45 mutants of beta-catenin aren't phosphorylated";"RAF activation";"Truncations of AMER1 destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Platelet sensitization by LDL";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
Mdes007200-RB	1	Reactome: R-HSA-264876	"Insulin processing"
Mdes019545-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes006399-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes001311-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes008067-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Mdes008802-RA	29	Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6781827;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-6781823;Reactome: R-HSA-167161;Reactome: R-HSA-6782135;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-427413;Reactome: R-HSA-5696400;Reactome: R-HSA-5696395;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-76042;Reactome: R-HSA-77075;Reactome: R-HSA-73779	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of TC-NER Pre-Incision Complex";"HIV Transcription Initiation";"Dual incision in TC-NER";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"NoRC negatively regulates rRNA expression";"Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
Mdes007168-RA	2	Reactome: R-HSA-203927;Reactome: R-HSA-8986944	"MicroRNA (miRNA) biogenesis";"Transcriptional Regulation by MECP2"
Mdes004394-RA	10	MetaCyc: PWY-5890;MetaCyc: PWY-7996;Reactome: R-HSA-2142789;MetaCyc: PWY-5891;MetaCyc: PWY-5839;MetaCyc: PWY-5849;MetaCyc: PWY-5844;MetaCyc: PWY-5892;MetaCyc: PWY-5895;KEGG: 00130+2.1.1.163	"Menaquinol-10 biosynthesis";"Menaquinol-4 biosynthesis I";"Ubiquinol biosynthesis";"Menaquinol-11 biosynthesis";"Menaquinol-7 biosynthesis";"Menaquinol-6 biosynthesis";"Menaquinol-9 biosynthesis";"Menaquinol-12 biosynthesis";"Menaquinol-13 biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis"
Mdes003437-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Mdes007247-RB	7	MetaCyc: PWY-6352;KEGG: 04070+2.7.1.67;Reactome: R-HSA-1660514;KEGG: 00562+2.7.1.67;Reactome: R-HSA-1660499;MetaCyc: PWY-6351;Reactome: R-HSA-1660516	"3-phosphoinositide biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the Golgi membrane";"Inositol phosphate metabolism";"Synthesis of PIPs at the plasma membrane";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of PIPs at the early endosome membrane"
Mdes002050-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes006344-RA	56	Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-180534;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-187577;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5362768;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-5668541;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-4641257;Reactome: R-HSA-349425	"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vpu mediated degradation of CD4";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Ub-specific processing proteases";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"TNFR2 non-canonical NF-kB pathway";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Neddylation";"Activation of NF-kappaB in B cells";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1"
Mdes007298-RA	1	Reactome: R-HSA-427652	"Sodium-coupled phosphate cotransporters"
Mdes000899-RB	11	Reactome: R-HSA-167152;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-167287;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167200;Reactome: R-HSA-167243	"Formation of HIV elongation complex in the absence of HIV Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated HIV elongation arrest and recovery"
Mdes002812-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Mdes010861-RA	2	Reactome: R-HSA-532668;KEGG: 00511+3.2.1.96	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Other glycan degradation"
Mdes002323-RA	24	Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-4086398;Reactome: R-HSA-202040;Reactome: R-HSA-381676;Reactome: R-HSA-418597;Reactome: R-HSA-416482;Reactome: R-HSA-8964616;Reactome: R-HSA-9009391;Reactome: R-HSA-456926;Reactome: R-HSA-500657;Reactome: R-HSA-418217;Reactome: R-HSA-163359;Reactome: R-HSA-392851;Reactome: R-HSA-418555;Reactome: R-HSA-432040;Reactome: R-HSA-392451;Reactome: R-HSA-418594;Reactome: R-HSA-420092;Reactome: R-HSA-392170;Reactome: R-HSA-6814122;Reactome: R-HSA-8964315;Reactome: R-HSA-416476;Reactome: R-HSA-400042	"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"Ca2+ pathway";"G-protein activation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G alpha (z) signalling events";"G alpha (12/13) signalling events";"G beta:gamma signalling through CDC42";"Extra-nuclear estrogen signaling";"Thrombin signalling through proteinase activated receptors (PARs)";"Presynaptic function of Kainate receptors";"G beta:gamma signalling through PLC beta";"Glucagon signaling in metabolic regulation";"Prostacyclin signalling through prostacyclin receptor";"G alpha (s) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through PI3Kgamma";"G alpha (i) signalling events";"Glucagon-type ligand receptors";"ADP signalling through P2Y purinoceptor 12";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through BTK";"G alpha (q) signalling events";"Adrenaline,noradrenaline inhibits insulin secretion"
Mdes014228-RA	14	Reactome: R-HSA-380320;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-9648025;Reactome: R-HSA-2565942;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5620912;Reactome: R-HSA-428890	"Recruitment of NuMA to mitotic centrosomes";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"EML4 and NUDC in mitotic spindle formation";"Regulation of PLK1 Activity at G2/M Transition";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Anchoring of the basal body to the plasma membrane";"Role of ABL in ROBO-SLIT signaling"
Mdes006002-RA	8	Reactome: R-HSA-68616;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-113507;Reactome: R-HSA-68949;Reactome: R-HSA-68827;Reactome: R-HSA-68689	"Assembly of the ORC complex at the origin of replication";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"E2F-enabled inhibition of pre-replication complex formation";"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex";"CDC6 association with the ORC:origin complex"
Mdes002219-RA	2	KEGG: 00770+2.7.1.24;MetaCyc: PWY-7851	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis II (eukaryotic)"
Mdes010141-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Mdes011715-RA	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
Mdes005532-RA	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Mdes000373-RA	3	Reactome: R-HSA-5358493;MetaCyc: PWY-6482;MetaCyc: PWY-7546	"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)"
Mdes004710-RA	16	Reactome: R-HSA-936440;MetaCyc: PWY-6607;MetaCyc: PWY-6538;Reactome: R-HSA-933541;Reactome: R-HSA-8851680;MetaCyc: PWY-5695;MetaCyc: PWY-6608;MetaCyc: PWY-6606;KEGG: 00230+1.17.1.4;Reactome: R-HSA-74259;Reactome: R-HSA-936964;MetaCyc: PWY-5497;MetaCyc: PWY-6596;MetaCyc: PWY-6999;Reactome: R-HSA-918233;Reactome: R-HSA-9013973	"Negative regulators of DDX58/IFIH1 signaling";"Guanosine nucleotides degradation I";"Caffeine degradation III (bacteria, via demethylation)";"TRAF6 mediated IRF7 activation";"Butyrophilin (BTN) family interactions";"Inosine 5'-phosphate degradation";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Purine metabolism";"Purine catabolism";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Purine nucleobases degradation II (anaerobic)";"Adenosine nucleotides degradation I";"Theophylline degradation";"TRAF3-dependent IRF activation pathway";"TICAM1-dependent activation of IRF3/IRF7"
Mdes005478-RA	11	Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68616;Reactome: R-HSA-9609523;Reactome: R-HSA-68962;Reactome: R-HSA-1799339;Reactome: R-HSA-68689;Reactome: R-HSA-1236974;Reactome: R-HSA-113507;Reactome: R-HSA-68949;Reactome: R-HSA-68827	"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"Activation of the pre-replicative complex";"SRP-dependent cotranslational protein targeting to membrane";"CDC6 association with the ORC:origin complex";"ER-Phagosome pathway";"E2F-enabled inhibition of pre-replication complex formation";"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex"
Mdes019750-RA	3	KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980	"Photosynthesis";"Oxidative phosphorylation";"ATP biosynthesis"
Mdes007128-RA	7	Reactome: R-HSA-381183;Reactome: R-HSA-983170;Reactome: R-HSA-3371453;Reactome: R-HSA-381070;Reactome: R-HSA-381042;Reactome: R-HSA-381033;Reactome: R-HSA-114608	"ATF6 (ATF6-alpha) activates chaperone genes";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of HSF1-mediated heat shock response";"IRE1alpha activates chaperones";"PERK regulates gene expression";"ATF6 (ATF6-alpha) activates chaperones";"Platelet degranulation"
Mdes004797-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes011932-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes007185-RA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
Mdes006256-RA	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
Mdes012768-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Mdes001234-RA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
Mdes014607-RA	1	Reactome: R-HSA-8876725	"Protein methylation"
Mdes002642-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Mdes012518-RA	5	Reactome: R-HSA-6811438;Reactome: R-HSA-6811434;Reactome: R-HSA-204005;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-dependent Golgi-to-ER retrograde traffic";"COPII-mediated vesicle transport";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
Mdes004823-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes000868-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Mdes016444-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes006485-RD	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes003477-RB	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes002522-RB	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Mdes006874-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Mdes009879-RA	12	Reactome: R-HSA-975957;Reactome: R-HSA-380994;Reactome: R-HSA-159236;Reactome: R-HSA-429958;Reactome: R-HSA-9010553;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-450385;Reactome: R-HSA-73856;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450604	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"ATF4 activates genes in response to endoplasmic reticulum stress";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA decay by 3' to 5' exoribonuclease";"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"RNA Polymerase II Transcription Termination";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA"
Mdes003690-RB	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Mdes019952-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes003264-RA	3	KEGG: 00460+3.5.1.1;Reactome: R-HSA-8964208;KEGG: 00250+3.5.1.1	"Cyanoamino acid metabolism";"Phenylalanine metabolism";"Alanine, aspartate and glutamate metabolism"
Mdes007858-RA	5	Reactome: R-HSA-9627069;Reactome: R-HSA-1237112;MetaCyc: PWY-4361;Reactome: R-HSA-111458;KEGG: 00270+4.2.1.109	"Regulation of the apoptosome activity";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Formation of apoptosome";"Cysteine and methionine metabolism"
Mdes009438-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Mdes019955-RA	1	Reactome: R-HSA-71064	"Lysine catabolism"
Mdes013193-RA	4	Reactome: R-HSA-5656169;Reactome: R-HSA-110312;Reactome: R-HSA-5656121;Reactome: R-HSA-5655862	"Termination of translesion DNA synthesis";"Translesion synthesis by REV1";"Translesion synthesis by POLI";"Translesion synthesis by POLK"
Mdes005461-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Mdes009245-RA	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
Mdes007195-RA	1	Reactome: R-HSA-264876	"Insulin processing"
Mdes003260-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-8873719	"RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation"
Mdes011593-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes020068-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Mdes008630-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes000440-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340	"PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation"
Mdes000604-RB	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Mdes003158-RA	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
Mdes001650-RA	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
Mdes006566-RA	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
Mdes000312-RC	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
Mdes003184-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Mdes006913-RA	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
Mdes004136-RC	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
Mdes001496-RA	2	KEGG: 00280+1.1.1.31;Reactome: R-HSA-70895	"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism"
Mdes003554-RA	8	Reactome: R-HSA-113501;Reactome: R-HSA-69091;Reactome: R-HSA-69183;Reactome: R-HSA-69166;Reactome: R-HSA-68952;Reactome: R-HSA-174411;Reactome: R-HSA-174430;Reactome: R-HSA-68962	"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Polymerase switching";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate";"DNA replication initiation";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand synthesis initiation";"Activation of the pre-replicative complex"
Mdes018620-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8949613	"Mitochondrial protein import";"Cristae formation"
Mdes003669-RA	12	MetaCyc: PWY-5856;MetaCyc: PWY-5870;MetaCyc: PWY-5871;MetaCyc: PWY-5873;MetaCyc: PWY-7233;MetaCyc: PWY-7230;MetaCyc: PWY-5872;Reactome: R-HSA-2142789;MetaCyc: PWY-5855;MetaCyc: PWY-5857;KEGG: 00130+1.14.99.60;MetaCyc: PWY-6708	"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-8 biosynthesis (prokaryotic)"
Mdes001919-RA	3	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-6807505	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes"
Mdes009641-RA	6	Reactome: R-HSA-110373;Reactome: R-HSA-110362;Reactome: R-HSA-73930;Reactome: R-HSA-73933;Reactome: R-HSA-110357;Reactome: R-HSA-5651801	"Resolution of AP sites via the multiple-nucleotide patch replacement pathway";"POLB-Dependent Long Patch Base Excision Repair";"Abasic sugar-phosphate removal via the single-nucleotide replacement pathway";"Resolution of Abasic Sites (AP sites)";"Displacement of DNA glycosylase by APEX1";"PCNA-Dependent Long Patch Base Excision Repair"
Mdes012564-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Mdes015825-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Mdes001830-RA	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
Mdes000253-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
Mdes008714-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes009968-RA	4	KEGG: 00670+1.5.1.6;KEGG: 00670+2.1.2.9;Reactome: R-HSA-196757;KEGG: 00970+2.1.2.9	"One carbon pool by folate";"One carbon pool by folate";"Metabolism of folate and pterines";"Aminoacyl-tRNA biosynthesis"
Mdes009830-RA	7	Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380320	"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes"
Mdes001006-RA	33	Reactome: R-HSA-2500257;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-180746;Reactome: R-HSA-4085377;Reactome: R-HSA-180910;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-165054;Reactome: R-HSA-5619107;Reactome: R-HSA-141444;Reactome: R-HSA-3232142;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-170822;Reactome: R-HSA-4615885;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-3371453	"Resolution of Sister Chromatid Cohesion";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"Nuclear import of Rev protein";"SUMOylation of SUMOylation proteins";"Vpr-mediated nuclear import of PICs";"Mitotic Prometaphase";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Rev-mediated nuclear export of HIV RNA";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of ubiquitinylation proteins";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA replication proteins";"snRNP Assembly";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"Regulation of HSF1-mediated heat shock response"
Mdes014555-RA	3	Reactome: R-HSA-5656121;Reactome: R-HSA-110312;Reactome: R-HSA-5655862	"Translesion synthesis by POLI";"Translesion synthesis by REV1";"Translesion synthesis by POLK"
Mdes000134-RB	4	Reactome: R-HSA-71737;MetaCyc: PWY-7807;KEGG: 00190+3.6.1.1;MetaCyc: PWY-7805	"Pyrophosphate hydrolysis";"Glyphosate degradation III";"Oxidative phosphorylation";"(aminomethyl)phosphonate degradation"
Mdes000422-RA	2	KEGG: 04070+2.7.11.13;Reactome: R-HSA-1660661	"Phosphatidylinositol signaling system";"Sphingolipid de novo biosynthesis"
Mdes004198-RA	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
Mdes003504-RB	4	MetaCyc: PWY-6823;MetaCyc: PWY-7887;KEGG: 00790+2.8.1.12;Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis";"Protein SAMPylation and SAMP-mediated thiolation";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
Mdes002521-RA	1	Reactome: R-HSA-5368286	"Mitochondrial translation initiation"
Mdes011636-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Mdes013540-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes012897-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes000449-RA	8	Reactome: R-HSA-6804757;Reactome: R-HSA-8866652;Reactome: R-HSA-6782135;Reactome: R-HSA-5689880;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-8948747	"Regulation of TP53 Degradation";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Dual incision in TC-NER";"Ub-specific processing proteases";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Regulation of PTEN localization"
Mdes017307-RB	2	KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1	"Purine metabolism";"Pentose phosphate pathway"
Mdes018256-RA	3	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-5617472	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
Mdes009017-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Mdes009001-RB	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Mdes006960-RA	13	KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-3928662;Reactome: R-HSA-416572;Reactome: R-HSA-4420097;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5627117;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-3928663	"mTOR signaling pathway";"Human papillomavirus infection";"EPHB-mediated forward signaling";"Sema4D induced cell migration and growth-cone collapse";"VEGFA-VEGFR2 Pathway";"Relaxin signaling pathway";"Thermogenesis";"G alpha (12/13) signalling events";"Human cytomegalovirus infection";"RHO GTPases Activate ROCKs";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"EPHA-mediated growth cone collapse"
Mdes000748-RB	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes006738-RA	13	Reactome: R-HSA-389357;Reactome: R-HSA-1632852;Reactome: R-HSA-5218920;Reactome: R-HSA-9639288;Reactome: R-HSA-1257604;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-6804757;Reactome: R-HSA-5674400;Reactome: R-HSA-3371571	"CD28 dependent PI3K/Akt signaling";"Macroautophagy";"VEGFR2 mediated vascular permeability";"Amino acids regulate mTORC1";"PIP3 activates AKT signaling";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Regulation of TP53 Degradation";"Constitutive Signaling by AKT1 E17K in Cancer";"HSF1-dependent transactivation"
Mdes015994-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Mdes018812-RA	5	Reactome: R-HSA-1912399;Reactome: R-HSA-1912420;Reactome: R-HSA-5083630;Reactome: R-HSA-350054;Reactome: R-HSA-1912408	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Pre-NOTCH Processing in Golgi";"Defective LFNG causes SCDO3";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation"
Mdes011253-RA	30	Reactome: R-HSA-917937;Reactome: R-HSA-8939902;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-2565942;Reactome: R-HSA-9020702;Reactome: R-HSA-5684264;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-2644606;Reactome: R-HSA-5607764;Reactome: R-HSA-983168;Reactome: R-HSA-1169091;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-202424;Reactome: R-HSA-400253;Reactome: R-HSA-187577;Reactome: R-HSA-1170546;Reactome: R-HSA-2644607;Reactome: R-HSA-5610783;Reactome: R-HSA-5610785;Reactome: R-HSA-2894862;Reactome: R-HSA-8854050;Reactome: R-HSA-195253;Reactome: R-HSA-2122947;Reactome: R-HSA-69231;Reactome: R-HSA-68949	"Iron uptake and transport";"Regulation of RUNX2 expression and activity";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of PLK1 Activity at G2/M Transition";"Interleukin-1 signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"CLEC7A (Dectin-1) signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Activation of NF-kappaB in B cells";"Neddylation";"FCERI mediated NF-kB activation";"Downstream TCR signaling";"Circadian Clock";"SCF(Skp2)-mediated degradation of p27/p21";"Prolactin receptor signaling";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Degradation of GLI2 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of beta-catenin by the destruction complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Cyclin D associated events in G1";"Orc1 removal from chromatin"
Mdes006632-RD	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes012774-RA	34	Reactome: R-HSA-69202;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-167158;Reactome: R-HSA-6807505;Reactome: R-HSA-167152;Reactome: R-HSA-72086;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-427413;Reactome: R-HSA-167246;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-77075;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-69231;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-69656;Reactome: R-HSA-6782135;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-69273;Reactome: R-HSA-113418;Reactome: R-HSA-5696395;Reactome: R-HSA-6796648;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-8939236;Reactome: R-HSA-73779	"Cyclin E associated events during G1/S transition";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Formation of the HIV-1 Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"Formation of HIV elongation complex in the absence of HIV Tat";"mRNA Capping";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"NoRC negatively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Cyclin D associated events in G1";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Cyclin A:Cdk2-associated events at S phase entry";"Dual incision in TC-NER";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"Cyclin A/B1/B2 associated events during G2/M transition";"Formation of the Early Elongation Complex";"Formation of Incision Complex in GG-NER";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
Mdes001386-RA	3	Reactome: R-HSA-3214847;Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"HATs acetylate histones";"DNA Damage Recognition in GG-NER";"UCH proteinases"
Mdes017755-RA	10	MetaCyc: PWY-4041;MetaCyc: PWY-7559;MetaCyc: PWY-6842;KEGG: 00460+2.3.2.2;MetaCyc: PWY-5826;MetaCyc: PWY-7112;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-8001;MetaCyc: PWY-4061;KEGG: 00430+2.3.2.2	"Gamma-glutamyl cycle";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II";"Cyanoamino acid metabolism";"Hypoglycin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Glutathione metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Taurine and hypotaurine metabolism"
Mdes015367-RA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Mdes012975-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes009036-RA	11	Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938;Reactome: R-HSA-5693568;Reactome: R-HSA-6804756;Reactome: R-HSA-5358565;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5358606;Reactome: R-HSA-5693616	"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Regulation of TP53 Activity through Phosphorylation";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Presynaptic phase of homologous DNA pairing and strand exchange"
Mdes015497-RA	16	Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-2408557;Reactome: R-HSA-72695	"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex"
Mdes006958-RB	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
Mdes004224-RA	2	Reactome: R-HSA-3108214;MetaCyc: PWY-7511	"SUMOylation of DNA damage response and repair proteins";"Protein ubiquitination"
Mdes016458-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes013922-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Mdes003529-RA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
Mdes019175-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes010336-RA	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Mdes009818-RA	5	Reactome: R-HSA-110328;Reactome: R-HSA-3108214;Reactome: R-HSA-110357;Reactome: R-HSA-5221030;Reactome: R-HSA-110329	"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"SUMOylation of DNA damage response and repair proteins";"Displacement of DNA glycosylase by APEX1";"TET1,2,3 and TDG demethylate DNA";"Cleavage of the damaged pyrimidine"
Mdes010463-RC	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Mdes010133-RA	3	Reactome: R-HSA-196757;MetaCyc: PWY-2161;KEGG: 00790+6.3.2.17	"Metabolism of folate and pterines";"Folate polyglutamylation";"Folate biosynthesis"
Mdes002628-RA	2	KEGG: 00230+3.5.3.4;MetaCyc: PWY-5697	"Purine metabolism";"Allantoin degradation to ureidoglycolate I (urea producing)"
Mdes011484-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes012662-RA	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
Mdes000335-RB	4	Reactome: R-HSA-446193;Reactome: R-HSA-4720489;KEGG: 00513+2.4.1.260;KEGG: 00510+2.4.1.260	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG12 causes ALG12-CDG (CDG-1g)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
Mdes013901-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes016151-RA	3	Reactome: R-HSA-2024101;Reactome: R-HSA-2206302;Reactome: R-HSA-2024096	"CS/DS degradation";"MPS I - Hurler syndrome";"HS-GAG degradation"
Mdes001603-RA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Mdes017332-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-450385	"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes001910-RA	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
Mdes004432-RA	2	KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753	"Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism"
Mdes012795-RA	1	KEGG: 00230+3.6.1.29	"Purine metabolism"
Mdes004564-RA	13	Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-6791226;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-975957	"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Mdes001939-RA	2	Reactome: R-HSA-2514853;Reactome: R-HSA-2299718	"Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes"
Mdes015815-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes016490-RA	56	Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5610785;Reactome: R-HSA-1236974;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-180585;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-5668541;Reactome: R-HSA-174113;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-5362768;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-9010553;Reactome: R-HSA-174084;Reactome: R-HSA-5607761;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-69601;Reactome: R-HSA-211733;Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-5689603;Reactome: R-HSA-5678895;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-187577;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-9604323;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-75815;Reactome: R-HSA-8939236	"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"GLI3 is processed to GLI3R by the proteasome";"ER-Phagosome pathway";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Vif-mediated degradation of APOBEC3G";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Neddylation";"Degradation of AXIN";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"TNFR2 non-canonical NF-kB pathway";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"Regulation of expression of SLITs and ROBOs";"Autodegradation of Cdh1 by Cdh1:APC/C";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"UCH proteinases";"Defective CFTR causes cystic fibrosis";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"SCF(Skp2)-mediated degradation of p27/p21";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Negative regulation of NOTCH4 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
Mdes006698-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Mdes002644-RA	5	Reactome: R-HSA-8957275;Reactome: R-HSA-879415;Reactome: R-HSA-532668;Reactome: R-HSA-381426;Reactome: R-HSA-901042	"Post-translational protein phosphorylation";"Advanced glycosylation endproduct receptor signaling";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Calnexin/calreticulin cycle"
Mdes002689-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes008906-RB	1	Reactome: R-HSA-6798163	"Choline catabolism"
Mdes005824-RA	2	KEGG: 00970+6.1.1.11;MetaCyc: PWY-6281	"Aminoacyl-tRNA biosynthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)"
Mdes000328-RC	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Mdes012070-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes006699-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes007507-RA	1	Reactome: R-HSA-6803204	"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"
Mdes006118-RC	3	Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369	"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis"
Mdes000413-RA	3	Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (i) signalling events";"G alpha (q) signalling events";"Peptide ligand-binding receptors"
Mdes004309-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes006612-RB	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes013025-RB	3	Reactome: R-HSA-5579007;KEGG: 00220+3.5.1.14;Reactome: R-HSA-5423646	"Defective ACY1 causes encephalopathy";"Arginine biosynthesis";"Aflatoxin activation and detoxification"
Mdes000077-RA	1	Reactome: R-HSA-1614558	"Degradation of cysteine and homocysteine"
Mdes006958-RC	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
Mdes012869-RE	5	Reactome: R-HSA-73621;MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8;Reactome: R-HSA-74259;Reactome: R-HSA-196807	"Pyrimidine catabolism";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Purine catabolism";"Nicotinate metabolism"
Mdes003670-RD	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
Mdes012595-RA	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
Mdes002816-RA	8	KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Signaling by Hippo";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection"
Mdes019692-RA	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Mdes015165-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Mdes011229-RA	3	Reactome: R-HSA-9609690;Reactome: R-HSA-6804757;Reactome: R-HSA-3899300	"HCMV Early Events";"Regulation of TP53 Degradation";"SUMOylation of transcription cofactors"
Mdes008712-RA	14	Reactome: R-HSA-5685942;Reactome: R-HSA-69091;Reactome: R-HSA-110312;Reactome: R-HSA-110320;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-5696400;Reactome: R-HSA-6782210;Reactome: R-HSA-5655862;Reactome: R-HSA-6782135;Reactome: R-HSA-5656121;Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-110314	"HDR through Homologous Recombination (HRR)";"Polymerase switching";"Translesion synthesis by REV1";"Translesion Synthesis by POLH";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Dual Incision in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by POLK";"Dual incision in TC-NER";"Translesion synthesis by POLI";"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex"
Mdes000317-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes018233-RA	13	MetaCyc: PWY-7184;Reactome: R-HSA-499943;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7222;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7198;MetaCyc: PWY-6545;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7210;MetaCyc: PWY-7226;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7220	"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Glutathione metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II"
Mdes013591-RB	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Mdes005068-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Mdes010722-RA	15	Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-2559580;Reactome: R-HSA-2559585;Reactome: R-HSA-9029569;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-8936459;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398;Reactome: R-HSA-8948700;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884	"Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Oxidative Stress Induced Senescence";"Oncogene Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by MECP2";"Ca2+ pathway";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX"
Mdes001820-RA	1	Reactome: R-HSA-381038	"XBP1(S) activates chaperone genes"
Mdes011194-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes010445-RA	5	KEGG: 00280+1.2.4.4;KEGG: 00640+1.2.4.4;MetaCyc: PWY-5046;Reactome: R-HSA-389661;Reactome: R-HSA-70895	"Valine, leucine and isoleucine degradation";"Propanoate metabolism";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Glyoxylate metabolism and glycine degradation";"Branched-chain amino acid catabolism"
Mdes014310-RA	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
Mdes012442-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Mdes003325-RA	56	Reactome: R-HSA-69481;Reactome: R-HSA-5610783;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-983168;Reactome: R-HSA-4608870;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-9604323;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-5607764;Reactome: R-HSA-8941858;Reactome: R-HSA-8852276;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-8939236;Reactome: R-HSA-75815;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-8951664;Reactome: R-HSA-1169091;Reactome: R-HSA-349425;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-5358346;Reactome: R-HSA-180585;Reactome: R-HSA-5668541;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-382556;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-5362768;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553	"G2/M Checkpoints";"Degradation of GLI2 by the proteasome";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Antigen processing: Ubiquitination & Proteasome degradation";"Asymmetric localization of PCP proteins";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Negative regulation of NOTCH4 signaling";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"CLEC7A (Dectin-1) signaling";"Regulation of RUNX3 expression and activity";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Neddylation";"Activation of NF-kappaB in B cells";"Autodegradation of the E3 ubiquitin ligase COP1";"Degradation of AXIN";"Downstream TCR signaling";"Hedgehog ligand biogenesis";"Vif-mediated degradation of APOBEC3G";"TNFR2 non-canonical NF-kB pathway";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"ABC-family proteins mediated transport";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs"
Mdes019122-RA	3	Reactome: R-HSA-189451;MetaCyc: PWY-7159;KEGG: 00860+1.3.3.3	"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism"
Mdes005636-RB	4	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72163	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway"
Mdes017134-RA	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
Mdes010675-RA	3	Reactome: R-HSA-6811436;Reactome: R-HSA-430039;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"mRNA decay by 5' to 3' exoribonuclease";"RAB GEFs exchange GTP for GDP on RABs"
Mdes001397-RA	17	Reactome: R-HSA-4615885;Reactome: R-HSA-9648025;KEGG: 04150+2.7.11.1;Reactome: R-HSA-68877;KEGG: 05165+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5663220;Reactome: R-HSA-174178;Reactome: R-HSA-9022692;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-141444;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1	"SUMOylation of DNA replication proteins";"EML4 and NUDC in mitotic spindle formation";"mTOR signaling pathway";"Mitotic Prometaphase";"Human papillomavirus infection";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"RHO GTPases Activate Formins";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of MECP2 expression and activity";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Thermogenesis";"Human cytomegalovirus infection";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway"
Mdes000805-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
Mdes011050-RA	10	KEGG: 00430+2.3.2.2;MetaCyc: PWY-4061;MetaCyc: PWY-8001;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-6842;MetaCyc: PWY-7559;MetaCyc: PWY-4041;MetaCyc: PWY-5826;MetaCyc: PWY-7112;KEGG: 00460+2.3.2.2	"Taurine and hypotaurine metabolism";"Glutathione-mediated detoxification I";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione metabolism";"Glutathione-mediated detoxification II";"Glutathione degradation (DUG pathway";"Gamma-glutamyl cycle";"Hypoglycin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Cyanoamino acid metabolism"
Mdes006433-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Mdes005728-RA	4	Reactome: R-HSA-5205685;Reactome: R-HSA-8934903;Reactome: R-HSA-936440;Reactome: R-HSA-1632852	"Pink/Parkin Mediated Mitophagy";"Receptor Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling";"Macroautophagy"
Mdes014301-RA	16	Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-9633012	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Mdes018287-RA	6	Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450385	"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Mdes001953-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Mdes002835-RA	3	KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361;MetaCyc: PWY-7174	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II"
Mdes004542-RA	6	MetaCyc: PWY-6368;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.36;KEGG: 00562+3.1.3.36;Reactome: R-HSA-1855204;Reactome: R-HSA-194840	"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"Rho GTPase cycle"
Mdes016481-RA	4	Reactome: R-HSA-5663213;Reactome: R-HSA-3928662;Reactome: R-HSA-8856828;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation"
Mdes009026-RA	4	Reactome: R-HSA-2029482;Reactome: R-HSA-8856828;Reactome: R-HSA-3928662;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs"
Mdes002054-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Mdes005529-RA	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
Mdes017129-RA	8	Reactome: R-HSA-6791055;MetaCyc: PWY-5723;Reactome: R-HSA-8950505;MetaCyc: PWY-1861;KEGG: 00030+2.2.1.2;Reactome: R-HSA-6791462;Reactome: R-HSA-163754;Reactome: R-HSA-71336	"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P";"Rubisco shunt";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P";"Insulin effects increased synthesis of Xylulose-5-Phosphate";"Pentose phosphate pathway"
Mdes000905-RA	1	Reactome: R-HSA-74217	"Purine salvage"
Mdes002591-RA	5	MetaCyc: PWY-6527;MetaCyc: PWY-6317;MetaCyc: PWY-3821;KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6	"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism"
Mdes007779-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes008242-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes003919-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Mdes007102-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes000295-RA	18	Reactome: R-HSA-1482788;Reactome: R-HSA-1483166;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482925;MetaCyc: PWY-8053;Reactome: R-HSA-1482922;MetaCyc: PWY-7417;MetaCyc: PWY-8051;MetaCyc: PWY-7409;Reactome: R-HSA-1482801;MetaCyc: PWY-6803;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7416;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482839;KEGG: 00590+3.1.1.4	"Acyl chain remodelling of PC";"Synthesis of PA";"Glycerophospholipid metabolism";"Acyl chain remodelling of PG";"Anandamide biosynthesis II";"Acyl chain remodelling of PI";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PS";"Phosphatidylcholine acyl editing";"Linoleic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Ether lipid metabolism";"Acyl chain remodelling of PE";"Arachidonic acid metabolism"
Mdes011381-RA	11	Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-4420332;Reactome: R-HSA-1971475;Reactome: R-HSA-3560801;Reactome: R-HSA-3656237;Reactome: R-HSA-3000170;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253;Reactome: R-HSA-2024096;Reactome: R-HSA-3560783	"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GAT3 causes JDSSDHD";"Defective EXT2 causes exostoses 2";"Syndecan interactions";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"HS-GAG degradation";"Defective B4GALT7 causes EDS, progeroid type"
Mdes002681-RB	3	Reactome: R-HSA-1989781;Reactome: R-HSA-212436;Reactome: R-HSA-381340	"PPARA activates gene expression";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation"
Mdes000654-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Mdes006554-RA	9	Reactome: R-HSA-6781827;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-110314	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Neddylation";"DNA Damage Recognition in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex"
Mdes016318-RA	5	MetaCyc: PWY-5686;MetaCyc: PWY-7791;KEGG: 00240+4.1.1.23;Reactome: R-HSA-500753;MetaCyc: PWY-7790	"UMP biosynthesis I";"UMP biosynthesis III";"Pyrimidine metabolism";"Pyrimidine biosynthesis";"UMP biosynthesis II"
Mdes006161-RA	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
Mdes017292-RA	11	Reactome: R-HSA-163615;Reactome: R-HSA-164378;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-5610787;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418555;Reactome: R-HSA-418597	"PKA activation";"PKA activation in glucagon signalling";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"Hedgehog 'off' state";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Adenylate cyclase activating pathway";"Purine metabolism";"G alpha (s) signalling events";"G alpha (z) signalling events"
Mdes008933-RB	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
Mdes009680-RB	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
Mdes016595-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Mdes000585-RA	21	MetaCyc: PWY-8004;KEGG: 00260+2.6.1.52;MetaCyc: PWY-8010;Reactome: R-HSA-977347;MetaCyc: PWY-5723;MetaCyc: PWY-7218;MetaCyc: PWY-6901;MetaCyc: PWY-6886;MetaCyc: PWY-2221;MetaCyc: PWY-6142;KEGG: 00010+2.7.1.40;Reactome: R-HSA-70171;MetaCyc: PWY-1042;KEGG: 00680+2.6.1.52;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40;KEGG: 00270+2.6.1.52;MetaCyc: PWY-7003;KEGG: 00750+2.6.1.52;KEGG: 00620+2.7.1.40;MetaCyc: PWY-7383	"Entner-Doudoroff pathway I";"Glycine, serine and threonine metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Serine biosynthesis";"Rubisco shunt";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Superpathway of glucose and xylose degradation";"1-butanol autotrophic biosynthesis (engineered)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis / Gluconeogenesis";"Glycolysis";"Glycolysis IV (plant cytosol)";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism";"Cysteine and methionine metabolism";"Glycerol degradation to butanol";"Vitamin B6 metabolism";"Pyruvate metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)"
Mdes009623-RA	9	Reactome: R-HSA-3928662;Reactome: R-HSA-438066;Reactome: R-HSA-9620244;Reactome: R-HSA-8849932;Reactome: R-HSA-442982;Reactome: R-HSA-9609736;Reactome: R-HSA-6794361;Reactome: R-HSA-5673001;Reactome: R-HSA-9617324	"EPHB-mediated forward signaling";"Unblocking of NMDA receptors, glutamate binding and activation";"Long-term potentiation";"Synaptic adhesion-like molecules";"Ras activation upon Ca2+ influx through NMDA receptor";"Assembly and cell surface presentation of NMDA receptors";"Neurexins and neuroligins";"RAF/MAP kinase cascade";"Negative regulation of NMDA receptor-mediated neuronal transmission"
Mdes015947-RA	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
Mdes014303-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Mdes018463-RA	3	KEGG: 00540+2.5.1.55;MetaCyc: PWY-1269;MetaCyc: PWY-7674	"Lipopolysaccharide biosynthesis";"CMP-3-deoxy-D-manno-octulosonate biosynthesis";"CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis"
Mdes007704-RC	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
Mdes002817-RA	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
Mdes010858-RA	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
Mdes008877-RA	6	Reactome: R-HSA-5654706;Reactome: R-HSA-5654712;Reactome: R-HSA-5654693;Reactome: R-HSA-5654700;Reactome: R-HSA-5673001;Reactome: R-HSA-9028731	"FRS-mediated FGFR3 signaling";"FRS-mediated FGFR4 signaling";"FRS-mediated FGFR1 signaling";"FRS-mediated FGFR2 signaling";"RAF/MAP kinase cascade";"Activated NTRK2 signals through FRS2 and FRS3"
Mdes002786-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Mdes013521-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Mdes014078-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes017922-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Mdes000506-RA	3	MetaCyc: PWY-7942;KEGG: 00480+4.3.2.7;Reactome: R-HSA-174403	"5-oxo-L-proline metabolism";"Glutathione metabolism";"Glutathione synthesis and recycling"
Mdes014758-RA	7	KEGG: 00940+1.11.1.7;MetaCyc: PWY-6824;MetaCyc: PWY-5469;MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-5461;MetaCyc: PWY-7445	"Phenylpropanoid biosynthesis";"Justicidin B biosynthesis";"Sesamin biosynthesis";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Betanidin degradation";"Luteolin triglucuronide degradation"
Mdes001288-RC	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Mdes001572-RA	8	Reactome: R-HSA-74217;Reactome: R-HSA-5683826;MetaCyc: PWY-6611;MetaCyc: PWY-7179-1;Reactome: R-HSA-6798695;MetaCyc: PWY-6609;KEGG: 00230+3.5.4.4;MetaCyc: PWY-7179	"Purine salvage";"Surfactant metabolism";"Adenine and adenosine salvage V";"Purine deoxyribonucleosides degradation II";"Neutrophil degranulation";"Adenine and adenosine salvage III";"Purine metabolism";"Purine deoxyribonucleosides degradation I"
Mdes001092-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Mdes014183-RA	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
Mdes001079-RB	27	Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-3301854;Reactome: R-HSA-1169408;Reactome: R-HSA-180910;Reactome: R-HSA-9610379;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-159230;Reactome: R-HSA-3371453;Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-4615885;Reactome: R-HSA-170822	"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Nuclear Pore Complex (NPC) Disassembly";"ISG15 antiviral mechanism";"Vpr-mediated nuclear import of PICs";"HCMV Late Events";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP Dependant Mature mRNA";"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein"
Mdes019020-RA	1	Reactome: R-HSA-264876	"Insulin processing"
Mdes003503-RA	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
Mdes010860-RA	3	Reactome: R-HSA-427975;Reactome: R-HSA-1268020;Reactome: R-HSA-8949613	"Proton/oligopeptide cotransporters";"Mitochondrial protein import";"Cristae formation"
Mdes004995-RA	5	Reactome: R-HSA-209560;Reactome: R-HSA-205043;Reactome: R-HSA-209543;Reactome: R-HSA-9020702;Reactome: R-HSA-5205685	"NF-kB is activated and signals survival";"NRIF signals cell death from the nucleus";"p75NTR recruits signalling complexes";"Interleukin-1 signaling";"Pink/Parkin Mediated Mitophagy"
Mdes012210-RC	16	MetaCyc: PWY-6142;MetaCyc: PWY-2221;MetaCyc: PWY-6886;MetaCyc: PWY-1622;MetaCyc: PWY-6901;Reactome: R-HSA-70263;MetaCyc: PWY-7218;MetaCyc: PWY-5723;MetaCyc: PWY-7124;KEGG: 00680+4.2.1.11;MetaCyc: PWY-8004;KEGG: 00010+4.2.1.11;MetaCyc: PWY-7003;MetaCyc: PWY-5484;MetaCyc: PWY-1042;Reactome: R-HSA-70171	"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)";"Formaldehyde assimilation I (serine pathway)";"Superpathway of glucose and xylose degradation";"Gluconeogenesis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Rubisco shunt";"Ethylene biosynthesis V (engineered)";"Methane metabolism";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Glycerol degradation to butanol";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Glycolysis"
Mdes007472-RA	12	MetaCyc: PWY-6803;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-8051;KEGG: 00590+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-7417;MetaCyc: PWY-7416	"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Anandamide biosynthesis I";"Arachidonic acid metabolism";"Linoleic acid metabolism";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)"
Mdes004544-RA	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
Mdes002686-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes004539-RA	2	Reactome: R-HSA-8866904;Reactome: R-HSA-8866907	"Negative regulation of activity of TFAP2 (AP-2) family transcription factors";"Activation of the TFAP2 (AP-2) family of transcription factors"
Mdes000944-RB	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes004753-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Mdes012500-RC	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
Mdes003546-RD	3	Reactome: R-HSA-74217;MetaCyc: PWY-6596;KEGG: 00230+3.5.4.6	"Purine salvage";"Adenosine nucleotides degradation I";"Purine metabolism"
Mdes000312-RI	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Mdes000933-RA	1	Reactome: R-HSA-77108	"Utilization of Ketone Bodies"
Mdes009403-RA	3	Reactome: R-HSA-8939902;Reactome: R-HSA-6785807;Reactome: R-HSA-8878166	"Regulation of RUNX2 expression and activity";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional regulation by RUNX2"
Mdes005872-RB	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Mdes020146-RA	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
Mdes012964-RA	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
Mdes015402-RA	1	MetaCyc: PWY-7533	"Gliotoxin biosynthesis"
Mdes003424-RA	16	Reactome: R-HSA-72764;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-2408557;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-1799339;Reactome: R-HSA-72702;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-72689	"Eukaryotic Translation Termination";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Selenocysteine synthesis";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Ribosomal scanning and start codon recognition";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of a pool of free 40S subunits"
Mdes002101-RA	4	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-6807505;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"RNA polymerase II transcribes snRNA genes";"Th1 and Th2 cell differentiation"
Mdes010494-RA	2	Reactome: R-HSA-418594;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
Mdes009710-RA	5	Reactome: R-HSA-427389;Reactome: R-HSA-6804758;Reactome: R-HSA-73762;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815	"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation";"RNA Polymerase I Transcription Initiation";"Regulation of PTEN gene transcription";"HDACs deacetylate histones"
Mdes007604-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Mdes009169-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes002576-RA	3	Reactome: R-HSA-156590;Reactome: R-HSA-8963684;Reactome: R-HSA-204174	"Glutathione conjugation";"Tyrosine catabolism";"Regulation of pyruvate dehydrogenase (PDH) complex"
Mdes004988-RA	4	Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
Mdes002072-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8869496	"Mitochondrial protein import";"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"
Mdes000215-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Mdes003262-RA	10	MetaCyc: PWY-5826;MetaCyc: PWY-7112;KEGG: 00460+2.3.2.2;MetaCyc: PWY-7559;MetaCyc: PWY-6842;MetaCyc: PWY-4041;KEGG: 00430+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4061;KEGG: 00480+2.3.2.2+3.4.19.13	"Hypoglycin biosynthesis";"4-hydroxy-2-nonenal detoxification";"Cyanoamino acid metabolism";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II";"Gamma-glutamyl cycle";"Taurine and hypotaurine metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Glutathione metabolism"
Mdes002991-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes008413-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Mdes017168-RA	5	KEGG: 00561+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22	"Glycerolipid metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Stachyose degradation";"Galactose metabolism"
Mdes009999-RA	2	Reactome: R-HSA-983231;Reactome: R-HSA-5205685	"Factors involved in megakaryocyte development and platelet production";"Pink/Parkin Mediated Mitophagy"
Mdes005979-RA	27	Reactome: R-HSA-159227;Reactome: R-HSA-9609690;Reactome: R-HSA-170822;Reactome: R-HSA-4615885;Reactome: R-HSA-168333;Reactome: R-HSA-159231;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-159230;Reactome: R-HSA-3108214;Reactome: R-HSA-4551638;Reactome: R-HSA-3371453;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-180746;Reactome: R-HSA-5619107;Reactome: R-HSA-180910;Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-3301854	"Transport of the SLBP independent Mature mRNA";"HCMV Early Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of DNA replication proteins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transcriptional regulation by small RNAs";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of chromatin organization proteins";"Regulation of HSF1-mediated heat shock response";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear import of Rev protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Vpr-mediated nuclear import of PICs";"HCMV Late Events";"ISG15 antiviral mechanism";"Nuclear Pore Complex (NPC) Disassembly"
Mdes011484-RB	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Mdes008450-RA	1	Reactome: R-HSA-380972	"Energy dependent regulation of mTOR by LKB1-AMPK"
Mdes004743-RA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
Mdes017307-RA	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
Mdes003727-RB	1	Reactome: R-HSA-191273	"Cholesterol biosynthesis"
Mdes017617-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Mdes001542-RB	9	Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-73779	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
Mdes004167-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Mdes016427-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Mdes005391-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Mdes009780-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes003210-RA	52	Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-9010553;Reactome: R-HSA-5607761;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5362768;Reactome: R-HSA-8939902;Reactome: R-HSA-4641258;Reactome: R-HSA-174178;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-5610780;Reactome: R-HSA-174113;Reactome: R-HSA-5668541;Reactome: R-HSA-5358346;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-349425;Reactome: R-HSA-1169091;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-1236978;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610785;Reactome: R-HSA-75815;Reactome: R-HSA-8939236;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-174154;Reactome: R-HSA-5632684;Reactome: R-HSA-5607764;Reactome: R-HSA-8852276;Reactome: R-HSA-5687128;Reactome: R-HSA-450408;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-2467813;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-983168;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-211733;Reactome: R-HSA-69601;Reactome: R-HSA-69481;Reactome: R-HSA-5610783	"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of expression of SLITs and ROBOs";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of RUNX2 expression and activity";"Degradation of DVL";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"Degradation of GLI1 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"TNFR2 non-canonical NF-kB pathway";"Hedgehog ligand biogenesis";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Neddylation";"Degradation of AXIN";"Autodegradation of the E3 ubiquitin ligase COP1";"Activation of NF-kappaB in B cells";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"Cross-presentation of soluble exogenous antigens (endosomes)";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"GLI3 is processed to GLI3R by the proteasome";"Ubiquitin-dependent degradation of Cyclin D";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"APC/C:Cdc20 mediated degradation of Securin";"Hedgehog 'on' state";"CLEC7A (Dectin-1) signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"MAPK6/MAPK4 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"Separation of Sister Chromatids";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"UCH proteinases";"Asymmetric localization of PCP proteins";"Antigen processing: Ubiquitination & Proteasome degradation";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"G2/M Checkpoints";"Degradation of GLI2 by the proteasome"
Mdes014772-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
Mdes006286-RA	4	Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-6814122;Reactome: R-HSA-112043	"G alpha (i) signalling events";"G-protein activation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"PLC beta mediated events"
Mdes017979-RA	1	Reactome: R-HSA-70921	"Histidine catabolism"
Mdes005883-RB	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes005326-RC	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Mdes010687-RA	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
Mdes013528-RA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Mdes001403-RA	9	Reactome: R-HSA-5633231;MetaCyc: PWY-5265;Reactome: R-HSA-446193;MetaCyc: PWY-6471;MetaCyc: PWY-6470;KEGG: 00513+2.4.1.141;MetaCyc: PWY-6385;KEGG: 00550+2.4.1.227;KEGG: 00510+2.4.1.141	"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Peptidoglycan biosynthesis II (staphylococci)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Various types of N-glycan biosynthesis";"Peptidoglycan biosynthesis III (mycobacteria)";"Peptidoglycan biosynthesis";"N-Glycan biosynthesis"
Mdes002820-RB	5	Reactome: R-HSA-936964;Reactome: R-HSA-168164;Reactome: R-HSA-937041;Reactome: R-HSA-937072;Reactome: R-HSA-166166	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Toll Like Receptor 3 (TLR3) Cascade";"IKK complex recruitment mediated by RIP1";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"MyD88-independent TLR4 cascade"
Mdes017452-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
Mdes004407-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Mdes012611-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Mdes010470-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Mdes005013-RA	8	MetaCyc: PWY-922;MetaCyc: PWY-7391;Reactome: R-HSA-2426168;Reactome: R-HSA-3214858;MetaCyc: PWY-6174;KEGG: 00900+2.7.1.36;Reactome: R-HSA-8939243;Reactome: R-HSA-191273	"Mevalonate pathway I";"Isoprene biosynthesis II (engineered)";"Activation of gene expression by SREBF (SREBP)";"RMTs methylate histone arginines";"Mevalonate pathway II (archaea)";"Terpenoid backbone biosynthesis";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Cholesterol biosynthesis"
Mdes009349-RA	2	Reactome: R-HSA-114608;KEGG: 00970+6.1.1.3	"Platelet degranulation";"Aminoacyl-tRNA biosynthesis"
Mdes007656-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Mdes001797-RA	5	MetaCyc: PWY-6527;MetaCyc: PWY-6317;MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;KEGG: 00520+2.7.1.6	"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism"
Mdes017911-RA	7	Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-2660826;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-9013507	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus"
Mdes001453-RA	11	Reactome: R-HSA-351202;KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107;KEGG: 00480+2.5.1.22;KEGG: 00330+2.5.1.22;KEGG: 00270+2.5.1.16;KEGG: 00330+2.5.1.16;MetaCyc: PWY-5196;MetaCyc: PWY-5194;KEGG: 00270+2.5.1.22;KEGG: 00480+2.5.1.16;MetaCyc: PWY-7377	"Metabolism of polyamines";"Porphyrin and chlorophyll metabolism";"Glutathione metabolism";"Arginine and proline metabolism";"Cysteine and methionine metabolism";"Arginine and proline metabolism";"Factor 430 biosynthesis";"Siroheme biosynthesis";"Cysteine and methionine metabolism";"Glutathione metabolism";"Cob(ii)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"
Mdes010231-RB	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Mdes006135-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Mdes013962-RA	6	Reactome: R-HSA-8964539;KEGG: 00330+2.6.1.13;MetaCyc: PWY-4981;MetaCyc: PWY-6922;MetaCyc: PWY-6344;MetaCyc: PWY-3341	"Glutamate and glutamine metabolism";"Arginine and proline metabolism";"L-proline biosynthesis II (from arginine)";"L-Ndelta-acetylornithine biosynthesis";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis III (from L-ornithine)"
Mdes012365-RA	31	Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-9609690;Reactome: R-HSA-159227;KEGG: 00513+2.4.1.131;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-3108214;Reactome: R-HSA-168276;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-4551295;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-180910;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-3301854;KEGG: 00510+2.4.1.131;Reactome: R-HSA-446193;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377	"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Early Events";"Transport of the SLBP independent Mature mRNA";"Various types of N-glycan biosynthesis";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"SUMOylation of DNA damage response and repair proteins";"NS1 Mediated Effects on Host Pathways";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Defective ALG11 causes ALG11-CDG (CDG-1p)";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Vpr-mediated nuclear import of PICs";"ISG15 antiviral mechanism";"HCMV Late Events";"Nuclear Pore Complex (NPC) Disassembly";"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins"
Mdes000550-RA	5	KEGG: 00330+1.5.1.2;Reactome: R-HSA-8964539;MetaCyc: PWY-3341;MetaCyc: PWY-6344;MetaCyc: PWY-4981	"Arginine and proline metabolism";"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)"
Mdes008603-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Mdes002610-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Mdes003546-RC	3	MetaCyc: PWY-6596;KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217	"Adenosine nucleotides degradation I";"Purine metabolism";"Purine salvage"
Mdes019372-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Mdes001565-RC	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Mdes007158-RA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.1	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Mdes004879-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Mdes001556-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Mdes011121-RE	3	Reactome: R-HSA-114608;Reactome: R-HSA-8957275;Reactome: R-HSA-381426	"Platelet degranulation";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
Mdes015150-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Mdes014006-RC	1	Reactome: R-HSA-8951664	"Neddylation"